FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Thompson, EF Cardone, VJ AF Thompson, EF Cardone, VJ TI Practical modeling of hurricane surface wind fields SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID TROPICAL STORM DELIA; BOUNDARY-LAYER; CIRCULATION MODELS; PARAMETERIZATION; COEFFICIENTS; CURRENTS; LANDFALL; SPEED AB Approaches for recreating hurricane surface winds in relation to ocean wave, surge, and current modeling are reviewed. A discrete numerical wind field model, based on original developments at New York University in the early 1970s and used extensively by the U.S. Army Corps of Engineers (CE) and others, is described in detail. Limitations of the model are also discussed. The CE model for hurricane surface wind fields has been a very useful tool in ocean response (OR) modeling for more than a decade. Recently, several aspects of the model were upgraded, including increased spatial resolution and capabilities for simulating a wider variety of radial pressure and wind profile forms. The upgraded features of the model are described, and their impact on hurricane simulations is illustrated with a hypothetical hurricane and with hurricanes Camille (1969) and Gilbert (1988). The upgrades are expected to lead to improvements in the accuracy of OR modeling, particularly for small, intense hurricanes and for well-documented storms with broad and/or multipeaked radial wind profiles. C1 OCEANWEATHER INC,COS COB,CT 06807. RP Thompson, EF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 44 TC 115 Z9 123 U1 2 U2 17 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1996 VL 122 IS 4 BP 195 EP 205 DI 10.1061/(ASCE)0733-950X(1996)122:4(195) PG 11 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA UT003 UT WOS:A1996UT00300006 ER PT J AU Malis, DJ Burton, DM AF Malis, DJ Burton, DM TI Peripheral nerve monitoring in children undergoing neuromuscular blockade after single-stage laryngotracheoplasty SO LARYNGOSCOPE LA English DT Article ID INTENSIVE-CARE UNIT; ANTERIOR CRICOID SPLIT; MUSCLE-RELAXANTS; STENOSIS RP Malis, DJ (reprint author), USA,BROOKE ARMY MED CTR,OTOLARYNGOL HEAD & NECK SERV,1950 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU LARYNGOSCOPE CO PI ST LOUIS PA 10 S BROADWAY 14TH FLOOR, ST LOUIS, MO 63102-1741 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD JUL PY 1996 VL 106 IS 7 BP 919 EP 921 DI 10.1097/00005537-199607000-00026 PG 3 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA UW659 UT WOS:A1996UW65900026 PM 8667995 ER PT J AU Barth, J AF Barth, J TI Funding a college education: Finding the right school for your child and the right fit for your budget - Drum,A, Kneedler,R SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 1996 VL 121 IS 12 BP 128 EP 128 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA UX600 UT WOS:A1996UX60000174 ER PT J AU Burgess, EB AF Burgess, EB TI Hacks - Wren,CS SO LIBRARY JOURNAL LA English DT Book Review RP Burgess, EB (reprint author), USA,COMBINED ARMS RES LIB,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 1996 VL 121 IS 12 BP 166 EP 166 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA UX600 UT WOS:A1996UX60000355 ER PT J AU Chen, JC Yang, B Kuo, LH SalamancaRiba, L Semendy, F Bambha, N AF Chen, JC Yang, B Kuo, LH SalamancaRiba, L Semendy, F Bambha, N TI Very low defect density ZnSe grown on GaAs by atmospheric pressure metal organic chemical vapor deposition SO MATERIALS CHEMISTRY AND PHYSICS LA English DT Article DE ZnSe epilayers; surface morphology; undoped GaAs ID STRUCTURAL-PROPERTIES; LASER-DIODES; EPITAXY AB Very low defect density ZnSe epilayers on GaAs substrates have been grown by metal-organic chemical vapor deposition (MOCVD) and the layers were characterized by various techniques. ZnSe epilayers were grown using diethylzinc (DEZn) and diethylselenide (DESe) as source materials. Growth studies were done at 400 degrees C under a Se-started growth condition in an atmospheric pressure MOCVD reactor. Different GaAs substrates were used to study the effect of substrates on the ZnSe quality. The as-grown ZnSe epilayers were characterized by double crystal X-ray diffraction, transmission electron microscopy (TEM), and scanning electron microscopy. The results show excellent surface morphology and crystal quality for ZnSe. The best material was grown on undoped GaAs. A full-width-at-half-maximum (FWHM) of the ZnSe (approximate to 0.2 mu m thick) X-ray peak as low as 90 arc s was achieved. TEM results show that ZnSe epilayers grown on undoped GaAs have a very low stacking fault density acid a large spacing between misfit dislocations. The density of the stacking faults is less than 10(5) cm(-2), which is more than three orders of magnitude lower than that of samples grown by conventional molecular beam epitaxy [J. Petruzzello et al., J. Appl. Phys., 63(1988) 2299] and MOCVD [J.L. Batstone et al., Philos. Mag. A, 66(1992) 609]. The spacing between misfit dislocations is between 5 and 10 mu m, which is 10-20 times that of reported samples of comparable thickness. C1 UNIV MARYLAND,DEPT MAT & NUCL ENGN,COLLEGE PK,MD 20742. ARMY RES LAB,IR OPT TECHNOL OFC,FT BELVOIR,VA 22060. RP Chen, JC (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,BALTIMORE,MD 21228, USA. RI Salamanca-Riba, Lourdes/B-3785-2009 OI Salamanca-Riba, Lourdes/0000-0001-8155-6403 NR 7 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0254-0584 J9 MATER CHEM PHYS JI Mater. Chem. Phys. PD JUL PY 1996 VL 45 IS 1 BP 88 EP 91 DI 10.1016/0254-0584(96)80055-1 PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA UT953 UT WOS:A1996UT95300017 ER PT J AU Nindl, BC Friedl, KE Marchitelli, LJ Shippee, RL Thomas, CD Patton, JF AF Nindl, BC Friedl, KE Marchitelli, LJ Shippee, RL Thomas, CD Patton, JF TI Regional fat placement in physically fit males and changes with weight loss SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE body composition; dual-energy x-ray absorptiometry; semistarvation; prolonged exercise; military personnel ID SUBCUTANEOUS ADIPOSE-TISSUE; BODY-FAT; MEN; RESPONSIVENESS; MOBILIZATION; RESTRICTION; POPULATION; DISEASE; RISK AB The abdomen is the principal site of fat deposition in men, and because abdominal fat is readily mobilized during exercise, the relative proportion of fat in the abdominal site may negatively correlate with the amount of regular physical activity, and even with physical fitness. This study presents data for regional fatness in 165 fit young men (U.S. Army Ranger candidates; initial body fat = 14.7 +/- 4.7%) assessed by dual-energy x-ray absorptiometry (DEXA), and for relative changes occurring following a 13% weight loss produced by a 1000 kcal . d(-1) energy deficit over 8 wk. Fat-free mass was constant across quintiles of percent body fat; only fat mass was different (16.2 +/- 2.2 kg and 6.0 +/- 1.4 kg at upper and lower quintiles, respectively). Truncal fat accounted for about 41% of total body fat in all quintiles; only the proportion of fat distributed to the arms was significantly higher in the fattest quintiles of men. Among a group of less intensely trained soldiers with the same average fatness as the highest quintile of Ranger students (20%), relative fat distribution to the trunk approached 50% of the total fat. Following weight loss, Ranger students lost half of the fat in all regions assessed (legs, arms, and trunk). The only significant association between regional losses and initial fatness was a greater proportion of fat lost from the arms in the fattest Rangers. These data suggest a ''fit fat'' distribution in active young men in which fat remains in the arms and legs until extreme weight loss occurs and the metabolically more active abdominal fat approaches depletion. C1 USA, EXPTL MED RES INST, OCCUPAT PHYSIOL DIV, NATICK, MA 01760 USA. USA, EXPTL MED RES INST, MIL NUTR DIV, NATICK, MA 01760 USA. OI Friedl, Karl/0000-0002-3134-8427 NR 38 TC 38 Z9 39 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUL PY 1996 VL 28 IS 7 BP 786 EP 793 DI 10.1097/00005768-199607000-00003 PG 8 WC Sport Sciences SC Sport Sciences GA UZ387 UT WOS:A1996UZ38700003 PM 8832530 ER PT J AU Oelschlaeger, TA Tall, BD AF Oelschlaeger, TA Tall, BD TI Uptake pathways of clinical isolates of Proteus mirabilis into human epithelial cell lines SO MICROBIAL PATHOGENESIS LA English DT Article DE Proteus mirabilis; invasion; internalization; microfilaments; microtubules; receptor-mediated endocytosis; endosome acidification ID URINARY-TRACT INFECTION; ESCHERICHIA-COLI; INVASION DETERMINANTS; CHLAMYDIA-TRACHOMATIS; MOLECULAR-CLONING; MAMMALIAN-CELLS; MOUSE MODEL; HELA-CELLS; ENDOCYTOSIS; SALMONELLA AB Proteus mirabilis isolates obtained from urine and faeces showed high invasion levels into several human epithelial cell lines in gentamicin assays. invasion efficiencies of isolate 102 from a monkey with diarrhoea equalled or even exceeded those of Salmonella typhi strain Ty2 (6.3 to 13.8% of the inoculum). Vegetative, non-swarming P. mirabilis invaded epithelial cells efficiently and were found in endosomes and free in the cytoplasm. Although inhibition of eukaryotic protein synthesis by cycloheximide did not reduce bacterial uptake, inhibition with bacteriostatic antibiotics of bacterial protein-, RNA-, or DNA-synthesis reduced invasion drastically. Involvement of eukaryotic structures and processes in internalization was determined by using various inhibitors in the invasion assay. Uptake of P. mirabilis isolated from urine into gut (INT407, HCT-8) cells and bladder (T24) cells was dramatically inhibited only by microfilament depolymerization. Internalization of faecal isolate 102 into gut or bladder epithelial cells was inhibited by depolymerization of microfilaments or microtubules. Engulfment of isolate 102 into T24 bladder cells was also reduced by inhibition of receptor-mediated endocytosis. Interference with endosome acidification decreased the number of intracellular bacteria of isolate 102 in all three cell lines. These results suggest that P. mirabilis isolates from different sources are internalized by epithelial cells by different eukaryotic processes, and that these processes can vary between cell lines. C1 WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. US FDA,DIV MICROBIOL STUDIES,WASHINGTON,DC 20204. RI Oelschlaeger, Tobias/B-5624-2015; OI Tall, Ben/0000-0003-0399-3629 NR 54 TC 10 Z9 11 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD JUL PY 1996 VL 21 IS 1 BP 1 EP 16 DI 10.1006/mpat.1996.0037 PG 16 WC Immunology; Microbiology SC Immunology; Microbiology GA UW559 UT WOS:A1996UW55900001 PM 8827702 ER PT J AU Ribera, JE Mozo, BT Mason, KT Murphy, BA AF Ribera, JE Mozo, BT Mason, KT Murphy, BA TI Communication survey of CH-47D crewmembers SO MILITARY MEDICINE LA English DT Article AB U.S. Army CH-47D cargo helicopter crewmembers are exposed to high levels of noise on a routine basis, yet must accomplish demanding missions that rely heavily on clear communication, This study looked at the auditory influences affecting communication by 17 crewmembers of a CH-47D Army Reserve unit, Results revealed (1) noise levels that exceed those of other Army rotary-winged aircraft, (2) different exposure levels for aviators and crewchiefs, (3) an overall preference for hearing ''critical or diagnostic'' aircraft sounds rather than wearing double hearing protection, (4) complaints of postflight tinnitus or muffled hearing, (5) helmet discomfort among the majority of crewmembers, (6) a high incidence of hearing loss, (7) difficulties in adjusting radio volume controls for aviators, and (8) the effects of eyeglasses or protective masks on hearing and communications. RP Ribera, JE (reprint author), USA,AEROMED RES LAB,FT RUCKER,AL 36362, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1996 VL 161 IS 7 BP 387 EP 391 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA UW855 UT WOS:A1996UW85500005 PM 8754711 ER PT J AU Stretch, RH Marlowe, DH Wright, KM Bliese, PD Knudson, KH Hoover, CH AF Stretch, RH Marlowe, DH Wright, KM Bliese, PD Knudson, KH Hoover, CH TI Post-traumatic stress disorder symptoms among Gulf War veterans SO MILITARY MEDICINE LA English DT Article ID EVENT SCALE; IMPACT; VALIDATION; COMBAT AB This study assessed the prevalence of risk for development of post-traumatic stress disorder (PTSD) symptoms among active duty and reserve veterans from Pennsylvania and Hawaii who either deployed (N = 1,524) or did not deploy (N = 2,727) to the Persian Gulf as a result of Operation Desert Storm. All participants anonymously completed a survey questionnaire that included the Impact of Event Scale and the Brief Symptom Inventory. Results indicate the likelihood of PTSD symptoms in approximately 8.0% of active duty veterans and 9.3% of reserve veterans who deployed to the Persian Gulf, PTSD risk comparisons are made with other active duty Army veterans assessed 1 year earlier, Sources of trauma are presented and implications for future military deployments on potential risks for developing PTSD are discussed. RP Stretch, RH (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 10 TC 51 Z9 53 U1 2 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1996 VL 161 IS 7 BP 407 EP 410 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UW855 UT WOS:A1996UW85500008 PM 8754714 ER PT J AU Kragh, JF Jones, BH Amaroso, PJ Heekin, RD AF Kragh, JF Jones, BH Amaroso, PJ Heekin, RD TI Parachuting injuries among army rangers: A prospective survey of an elite airborne battalion SO MILITARY MEDICINE LA English DT Article AB Injuries are common in sports and military parachuting, This paper presents results of a prospective survey of parachuting injuries in an airborne Ranger battalion. The Ranger regiment is the U.S Army's most elite airborne infantry, prepared for worldwide deployment without advanced notice, Average unit size was 556 Rangers for the 18 months of follow-up. Other variables examined were type of landing area and time of day, During the follow-up period, all injuries occurring in the battalion were documented, as were all airborne operations, During the survey period, 65 airborne operations were conducted (7,948 static-line and free-fall jumps), which caused 163 injuries to Rangers. Fifty-five percent of the operations and jumps were made at night, and 63, 23, and 14% of operations were onto fields, airports, and unimproved airplane landing strips, respectively. All operations were performed in a tactical environment with equipment, The ''static-line'' injury rate was 2.2%, The types of injuries were similar to those found in previous reports. Dirt landing strips (4.7% injured) and airports (2.3%) appeared to be more hazardous landing areas than fields (1.6%) and water (0%), and more injuries occurred during night operations (2.7%) than during the day (1.4%), Two and one-half times as many severe injuries occurred at night versus day, This type of information is important for combat airborne operations. RP Kragh, JF (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,DIV ORTHOPED,FT GORDON,GA 30905, USA. NR 29 TC 18 Z9 18 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1996 VL 161 IS 7 BP 416 EP 419 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UW855 UT WOS:A1996UW85500010 PM 8754716 ER PT J AU Zhao, F Zhou, HY Wu, ZK Yu, FTS McMillen, DK AF Zhao, F Zhou, HY Wu, ZK Yu, FTS McMillen, DK TI Temperature dependence of light-induced scattering in a Ce:Fe:LiNbO3 photorefractive crystal SO OPTICAL ENGINEERING LA English DT Article DE photorefractive materials; lithium niobate; light scattering; volume holograms; two-wave mixing; holographic storage ID HOLOGRAPHIC STORAGE; LINBO3; GRATINGS; SUPPRESSION; BATIO3; MEDIA; LASER AB Light-induced scattering in a Ce:Fe:LiNbO3 crystal is highly temperature dependent. By considering the effect due to thermally activated ions in a photorefractive crystal, we have shown that the photoinduced space-charge field is neutralized by the activated ions, This neutralization in turn leads to a reduction of scattering noise in the crystal. By raising the crystal temperature, we have observed a reduction in scattering noise, which is consistent with our prediction. The signal-to-noise ratio (SNR) in a two-wave mixing amplification due to thermal activation effect is analyzed. Experimental demonstrations using a Ce:Fe:LiNbO3 crystal are provided in which we have shown that the SNR improves as the crystal temperature increases. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802. USA,MISSILE COMMAND,PHOTON GRP,REDSTONE ARSENAL,AL 35898. NR 30 TC 3 Z9 9 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 1996 VL 35 IS 7 BP 1985 EP 1992 DI 10.1117/1.600775 PG 8 WC Optics SC Optics GA VA116 UT WOS:A1996VA11600024 ER PT J AU Videen, G AF Videen, G TI Light scattering from an irregular particle behind a plane interface SO OPTICS COMMUNICATIONS LA English DT Article ID SPHERE; SURFACE AB A formulation is derived by which the light scattered from an irregular particle behind a plane interface can be found. The only knowledge required of the particle is its scattering coefficients when the plane interface is not present. It is sufficiently general that the particle can be composed of inhomogeneous media or of multiple subparticles. The solution is derived by expanding the fields in terms of vector spherical harmonics and translating them between the coordinate systems of the particle and the image particle. In this way, the boundary conditions on both the particle and the plane interface can be satisfied. Scattering curves from small spheroids behind an interface are used to illustrate the theory. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88001. NR 24 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUL 1 PY 1996 VL 128 IS 1-3 BP 81 EP 90 DI 10.1016/0030-4018(96)00156-3 PG 10 WC Optics SC Optics GA UV601 UT WOS:A1996UV60100015 ER PT J AU vanderGracht, J Dowski, ER Taylor, MG Deaver, DM AF vanderGracht, J Dowski, ER Taylor, MG Deaver, DM TI Broadband behavior of an optical-digital focus-invariant system SO OPTICS LETTERS LA English DT Article ID OTF AB We present experimental evidence that demonstrates a greatly increased depth of field in a broadband-illuminated imaging system through the use of a special-purpose phase mask and digital filtering. The phase mask is of a simple rectangularly separable cubic-phase design, whereas the digital filtering used was a simple object-independent least-squares inverse filter. We demonstrate successful operation of the system over a range corresponding to 30 times the Hopkins criterion for allowable misfocus. (C) 1996 Optical Society of America. C1 UNIV COLORADO,DEPT ELECT ENGN,IMAGING SYST LAB,BOULDER,CO 80309. RP vanderGracht, J (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 7 TC 49 Z9 49 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 1 PY 1996 VL 21 IS 13 BP 919 EP 921 DI 10.1364/OL.21.000919 PG 3 WC Optics SC Optics GA UU284 UT WOS:A1996UU28400003 PM 19876204 ER PT J AU Phillips, PJ Vardi, Y AF Phillips, PJ Vardi, Y TI Efficient illumination normalization of facial images SO PATTERN RECOGNITION LETTERS LA English DT Article DE illumination normalization; face recognition; histogram modification AB This paper presents a simple method for normalizing non-linear illumination variations in facial images. Facial pixels are modelled by an empirical probability distribution, which is estimated by kernel density estimation. The illumination is normalized by transforming the empirical distribution function. C1 RUTGERS STATE UNIV,DEPT STAT,NEW BRUNSWICK,NJ 08903. RP Phillips, PJ (reprint author), USA,AMSRL SE RT,10235 BURBECK RD,SUITE 110,FT BELVOIR,VA 22060, USA. NR 14 TC 26 Z9 29 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8655 J9 PATTERN RECOGN LETT JI Pattern Recognit. Lett. PD JUL 1 PY 1996 VL 17 IS 8 BP 921 EP 927 DI 10.1016/0167-8655(96)00046-3 PG 7 WC Computer Science, Artificial Intelligence SC Computer Science GA UX875 UT WOS:A1996UX87500012 ER PT J AU Fleischhauer, M Manka, AS AF Fleischhauer, M Manka, AS TI Propagation of laser pulses and coherent population transfer in dissipative three-level systems: An adiabatic dressed-state picture SO PHYSICAL REVIEW A LA English DT Article ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY; WAVELENGTH OPTICAL PULSES; VIBRATIONAL LEVELS; 3-STATE SYSTEMS; TRANSITIONS; DRIVEN; CONTINUUM; PHOTON AB The interaction of a pair of copropagating pulses with three-level Lambda-type atoms is discussed in terms of time-dependent coupled and decoupled superpositions \+/-] of the lower levels. Due to the explicit time dependence of these states there is a nonadiabatic coupling between the ''bright'' state \+] and the ''dark'' state \-] in addition to the strong coupling between \+] and the upper level \a]. We show that under quasiadiabatic conditions and in the presence of decay from the upper level this coupling can be treated perturbatively and the Maxwell-Bloch equations can be solved analytically. With the help of such a perturbation approach, coherent population transfer and formstable laser pulse propagation are studied. C1 USA,MISSILE COMMAND,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898. RP Fleischhauer, M (reprint author), UNIV MUNICH,SEKT PHYS,THERESIENSTR 37,D-80333 MUNICH,GERMANY. RI Fleischhauer, Michael/G-6716-2011 NR 39 TC 113 Z9 116 U1 0 U2 11 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL PY 1996 VL 54 IS 1 BP 794 EP 803 DI 10.1103/PhysRevA.54.794 PG 10 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA UX034 UT WOS:A1996UX03400093 ER PT J AU Bare, AC McAnaw, MB Pritchard, AE Struebing, JG Smutok, MA Christie, DS Domenech, M Bare, MA Bloodworth, ML Seal, LA AF Bare, AC McAnaw, MB Pritchard, AE Struebing, JG Smutok, MA Christie, DS Domenech, M Bare, MA Bloodworth, ML Seal, LA TI Phonophoretic delivery of 10% hydrocortisone through the epidermis of humans as determined by serum cortisol concentrations SO PHYSICAL THERAPY LA English DT Article DE hydrocortisone; phonophoresis; serum analysis; ultrasound ID TRANSDERMAL DRUG DELIVERY; PERCUTANEOUS-ABSORPTION; ULTRASOUND; MEDIA AB Background and Purpose. The purpose of this investigation was to determine whether application of hydrocortisone phonophoresis enhances transcutaneous delivery of topically applied hydrocortisone in humans, as determined by blood cortisol levels. Subjects. The subjects were 16 men and women, between the ages of 18 and 33 years ((X) over bar = 25, SD = 2.74), without symptoms of any ongoing inflammatory condition. Methods. A gel coupling medium containing 10% hydrocortisone acetate was used. Ultrasound was delivered over a 50-cm(2) area for 5 minutes at an intensity of 1.0 W/cm(2) and a frequency of 1.0 MHz. Each subjects received a control treatment (ultrasound alone) and an experimental treatment (hydrocortisone phonophoresis) on the volar aspect of the forearm 1 week apart. Blood was drawn, under both control and experimental conditions, from a cubital vein just proximal to the treatment site prior to each treatment and 0, 5, and 15 minutes posttreatment. Serum cortisol concentrations were measured using a fluorescence polarization immunoassay. Results. No rise in serum cortisol concentrations following hydrocortisone phonophoresis was detected. Conclusion and Discussion. These findings suggest that there was no penetration of hydrocortisone through the epidermis and into the underlying vasculature. Clinical implications regarding hydrocortisone levels within the subcutaneous tissues are discussed, and further research is suggested. C1 EISENHOWER ARMY MED CTR,AUGUSTA,GA 30905. WINN ARMY COMMUNITY HOSP,FT STEWART,GA 31314. MARINE CORPS RECRUIT DEPOT,PARRIS ISL,SC 29905. USA,ENVIRONM MED RES INST,OCCUPAT MED DIV,NATICK,MA 01760. BAYLOR UNIV,USA,GRAD PROGRAM PHYS THERAPY,AMEDD CTR & SCH,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,CHEM SECT,FT SAM HOUSTON,TX 78234. RP Bare, AC (reprint author), BLANCHFIELD ARMY COMMUNITY HOSP,FT CAMPBELL,KY 42223, USA. NR 29 TC 23 Z9 23 U1 0 U2 0 PU AMER PHYS THER ASSN PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD JUL PY 1996 VL 76 IS 7 BP 738 EP 745 PG 8 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA UW601 UT WOS:A1996UW60100006 PM 8677278 ER PT J AU Maier, RS Bernard, RS Grunau, DW AF Maier, RS Bernard, RS Grunau, DW TI Boundary conditions for the lattice Boltzmann method SO PHYSICS OF FLUIDS LA English DT Article ID EQUATION; SIMULATIONS; FLOWS AB When the Lattice Boltzmann Method (LBM) is used for simulating continuum fluid flow, the discrete mass distribution must satisfy imposed constraints for density and momentum along the boundaries of the lattice. These constraints uniquely determine the three-dimensional (3-D) mass distribution for boundary nodes only when the number of external (inward-pointing) lattice links does not exceed four. We propose supplementary rules for computing the boundary distribution where the number of external links does exceed four, which is the case for all except simple rectangular lattices. Results obtained with 3-D body-centered-cubic lattices are presented for Poiseuille flow, porous-plate Couette flow, pipe flow, and rectangular duct flow. The accuracy of the two-dimensional (2-D) Poiseuille and Couette flaws persists even when the mean free path between collisions is large, but that of the 3-D duct flow deteriorates markedly when the mean free path exceeds the lattice spacing. Accuracy in general decreases with Knudsen number and Mach number, and the product of these two quantities is a useful index for the applicability of LBM to 3-D low-Reynolds-number flow. (C) 1996 American Institute of Physics. C1 ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. LOS ALAMOS NATL LAB,LOS ALAMOS,NM 87544. THINKING MACHINES CORP,LOS ALAMOS,NM 87544. RP Maier, RS (reprint author), MINNESOTA SUPERCOMP CTR INC,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 23 TC 161 Z9 170 U1 4 U2 42 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1070-6631 J9 PHYS FLUIDS JI Phys. Fluids PD JUL PY 1996 VL 8 IS 7 BP 1788 EP 1801 DI 10.1063/1.868961 PG 14 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA UU385 UT WOS:A1996UU38500013 ER PT J AU Anderson, SM Saviolakis, GA Bauman, RA Chu, KY Ghosh, S Kant, GJ AF Anderson, SM Saviolakis, GA Bauman, RA Chu, KY Ghosh, S Kant, GJ TI Effects of chronic stress on food acquisition, plasma hormones, and the estrous cycle of female rats SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE stress; chronic stress; female rats; estrous cycle; ACTH; prolactin; corticosterone; estradiol; progesterone ID CORTICOTROPIN-RELEASING FACTOR; PITUITARY; SECRETION; CORTICOSTERONE; PROGESTERONE; PROLACTIN AB Our laboratory has previously conducted a number of studies to determine the effects of chronic stress on the physiology and behavior of male rats. The present study was performed to extend these investigations to female rats. Female rats were chronically stressed using a behavioral paradigm of around-the-clock signalled intermittent foot shock in which some rats can pull a chain to avoid/escape shock (stress) while another group of rats is yoked to the first group (yoked-stress) and does not have control over shock termination. Control rats were never shocked but all groups lever pressed for food pellets on an FR1 schedule (one pellet per lever press). Daily vaginal samples were obtained for several weeks prior to stress onset and throughout the chronic stress period. After 14 days of stress, the experiment was terminated and morning blood samples were collected for hormonal assays. Stress transiently decreased lever pressing for food pellets and body weights, but both measures returned to prestress levels by day 14 of stress. Plasma adrenocorticotropic hormone (ACTH) concentrations were significantly elevated in the yoked-stress group compared to the other two groups, but there were no significant effects of 14 days of stress treatment on plasma corticosterone, prolactin, estradiol, or progesterone concentrations. There were no significant differences in estrous cycle length among experimental groups. RP Anderson, SM (reprint author), WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 31 TC 37 Z9 38 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JUL PY 1996 VL 60 IS 1 BP 325 EP 329 DI 10.1016/0031-9384(96)00023-6 PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA UU132 UT WOS:A1996UU13200052 PM 8804685 ER PT J AU Sasser, LB Cushing, JA Dacre, JC AF Sasser, LB Cushing, JA Dacre, JC TI Two-generation reproduction study of sulfur mustard in rats SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE sulfur mustard; reproduction; multigeneration; rats ID GAS WORKERS; POISON AB Comprehensive data are not available to evaluate the potential risk to reproduction from exposure to sulfur mustard (HD), [bis(2-chloroethyl) sulfide]; thus, the reproductive effects of HD were evaluated in Sprague-Dawley rats, Groups, of rats (27 females and 20 males/group/generation) were gavaged with 0, 0.03, 0.1, or 0.4 mg/kg HD 5 d/week for 13 weeks prior to mating and throughout gestation, parturition, and lactation in a 42-week, 2-generation study, Growth of adult F-1 rats of both sexes was reduced by the 0.4 mg/kg exposure, There were no significant effects on reproductive function or pregnancy outcome in either generation, except for an altered sex ratio in the 0.4 mg/kg group, Although not different at birth, growth of the 0.4 mg/kg F-1 and F-2 offspring was depressed during lactation. A dose-related lesion of the squamous epithelium of the forestomach was observed in adults of both sexes and both the F-1 and F-2 generation, For a given treatment, the incidence was approximately the same for each sex at each generation, When animals were pooled by sex and generation, approximately 70% (66 out of 94) of the low dose group had only mild microscopic lesions, 72% (68 out of 94) of the intermediate dose group had moderate lesions, and 81% (76 out of 94) of the high group had marked lesions. The lesion, acanthosis, was characterized by thickening of the squamous musoca with varying degrees of hyperkeratosis, Benign neoplasms of the forestomach were found in about 10% of the intermediate and high dose groups in both F-0 and F-1 generations, Based on these results, the No-Observable-Adverse-Effect-Level (NOAEL) is 0.1 mg/kg/d. C1 USA, BIOMED RES & DEV LAB, FT DETRICK, MD USA. RP Sasser, LB (reprint author), PACIFIC NW LAB, HLTH DIV, POB 999, RICHLAND, WA 99352 USA. NR 19 TC 10 Z9 11 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD JUL-AUG PY 1996 VL 10 IS 4 BP 311 EP 319 DI 10.1016/0890-6238(96)00060-3 PG 9 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA UZ617 UT WOS:A1996UZ61700008 PM 8829254 ER PT J AU Brown, EA AF Brown, EA TI Conforming the government R&D function with the requirements of the government performance and results act - Planning the unplannable? Measuring the unmeasurable? SO SCIENTOMETRICS LA English DT Article AB The Army Research Laboratory (ARL) was designated a Pilot Project for Performance Planning under the Government Performance and Results Act of 1993. Of the more than 80 such pilot projects government-wide, ARL was the only organization to represent the R&D community. As such, it was required to break new ground in both the planning and the evaluation of basic and applied research. This paper discusses the efforts made by ARL in both these areas, the insights drawn from these efforts, and the lessons learned. RP Brown, EA (reprint author), USA,RES LAB,SPECIAL PROJECTS OFF,ADELPHI,MD 20783, USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0138-9130 J9 SCIENTOMETRICS JI Scientometrics PD JUL-AUG PY 1996 VL 36 IS 3 BP 445 EP 470 DI 10.1007/BF02129605 PG 26 WC Computer Science, Interdisciplinary Applications; Information Science & Library Science SC Computer Science; Information Science & Library Science GA VG505 UT WOS:A1996VG50500011 ER PT J AU Croce, F Appetecchi, GB Slane, S Salomon, M Tavarez, M Arumugam, S Wang, Y Greenbaum, SG AF Croce, F Appetecchi, GB Slane, S Salomon, M Tavarez, M Arumugam, S Wang, Y Greenbaum, SG TI Impedance and lithium-7 NMR studies of polymer electrolytes based on poly(vinylidene fluoride) SO SOLID STATE IONICS LA English DT Article; Proceedings Paper CT 10th International Conference on Solid State Ionics (SSI-10) CY DEC 03-08, 1995 CL SINGAPORE, SINGAPORE SP Natl Univ Singapore, Dept Phys, Asian Soc Solid State Ion DE polymer electrolytes; NMR; plasticizer; PVDF; impedance spectroscopy; lithium batteries ID LI-7 NMR; IONIC-CONDUCTIVITY AB Composite polymer electrolytes consisting of at least 35 mol% poly(vinylidene fluoride) (PVdF) and mixtures of propylene carbonate (PC) and dimethyl formamide (DMF), lithium salts (LiAsF6, LiN(CF3SO2)(2), or LiC(CF3SO2)(3), and small amounts (similar to 5 mol%) of plasticizer, either diethylphthalate (DEP) or dibutylphthalate (DBP), were investigated by differential scanning calorimetry, complex impedance analysis and Li-7 NMR spectroscopy. Despite the composite nature of these materials, they all exhibit a single glass transition temperature (T-g). Significant variations of T-g with the two different plasticizers were noted. The sample containing the LiC(CF3SO2)(3) salt has the highest electrical conductivity of the series, similar to 3X10(-4) S/cm at 25 degrees C. Time-dependent impedance measurements utilizing cells with lithium electrodes revealed the growth of a passivating interface layer comparable to those observed with other polymer electrolytes. The onset of NMR motional line-narrowing is correlated with T-g for all samples prepared with DBP, as is known to occur in 'single component' polyether-based electrolytes. However the onset of narrowing for the samples containing DEP occurs about 30 K above T-g. Lithium-7 spin-lattice relaxation measurements exhibit non-exponential recovery profiles below T-g, with about similar to 15% of the Li species relax differently than the majority. Activation energies extracted from 7LiT(1) data show that localized Li motion is significantly impeded in the DEP-containing samples, relative to those prepared with DBP. C1 USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703. CUNY HUNTER COLL,DEPT PHYS,NEW YORK,NY 10021. RP Croce, F (reprint author), UNIV ROMA LA SAPIENZA,DEPT CHEM,I-185 ROME,ITALY. RI Croce, Fausto/J-8193-2012 NR 15 TC 32 Z9 32 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2738 J9 SOLID STATE IONICS JI Solid State Ion. PD JUL PY 1996 VL 86-8 BP 307 EP 312 DI 10.1016/0167-2738(96)00137-3 PN 1 PG 6 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA VV764 UT WOS:A1996VV76400053 ER PT J AU Torrington, KG Bilello, JF Hopkins, TK Hall, EA AF Torrington, KG Bilello, JF Hopkins, TK Hall, EA TI Postoperative pulmonary changes after laparoscopic cholecystectomy SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID UPPER ABDOMINAL-SURGERY; COMPLICATIONS AB Laparoscopic cholecystectomy (LC) has been widely used in recent years because of short postoperative hospital stays and low morbidity. In this study, 24 patients were prospectively evaluated with preoperative and postoperative spirometry, arterial blood gas determinations, and chest radiographs to quantitate the magnitude of postoperative pulmonary changes after LC. Statistically significant reductions were noted in forced vital capacity (FVC) (mean decrease, 810 mL) and forced expired volume in 1 second (FEV(1)) (mean decrease, 420 mL). Clinically important changes in arterial blood gas values did not occur. Of 20 postoperative chest films, 7 showed the development of atelectasis or effusion and 9 showed persistence of subdiaphragmatic free air 24 hours after LC. In summary, LC caused mean decreases of 23% in FVC and 16% in FEV(1) 24 hours after surgery. The physiologic derangements that follow LC are sufficiently small that all but the most severely impaired patients with pulmonary disease should be able to tolerate this operation. C1 WALTER REED ARMY MED CTR,DEPT SURG,GEN SURG SERV,WASHINGTON,DC 20307. RP Torrington, KG (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 11 TC 6 Z9 7 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD JUL PY 1996 VL 89 IS 7 BP 675 EP 678 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UY124 UT WOS:A1996UY12400005 PM 8685752 ER PT J AU Polly, DW Kilkelly, FX McHale, KA Asplund, LM Mulligan, M Chang, AS AF Polly, DW Kilkelly, FX McHale, KA Asplund, LM Mulligan, M Chang, AS TI Measurement of lumbar lordosis - Evaluation of intraobserver, interobserver, and technique variability SO SPINE LA English DT Article DE lordosis; lumbar spine; sagittal plane; x-ray measurement ID ZIELKE INSTRUMENTATION; IDIOPATHIC SCOLIOSIS; SAGITTAL PLANE; KYPHOSIS; FUSION AB Study Design. Sixty radiographs were measured on two separate occasions by three physicians using four different techniques to evaluate the reliability and reproducibility of the measurement of lumbar lordosis. Objective. To evaluate clinical methods of measuring lumbar lordosis, determining intraobserver and interobserver reliability. Summary of Background Data. Several different methods are used to measure lumbar lordosis. The reliability and reproducibility of these has not been well studied. Methods. Sixty lateral full spine radiographs were obtained, labeled, and the lumbar lordosis measured independently by three practitioners who routinely perform these measurements. Four measurement techniques were used. These included measurements from the inferior endplates of T12 to the superior endplate of S1; the superior endplate of L1 to the superior endplate of S1; the inferior endplate of T12 to the inferior endplate of L5; and the superior endplate of L1 to the inferior endplate of L5. The measurements then were repeated after relabeling. Results. Intraobserver reliability coefficients ranged from 0.83 to 0.92, indicating excellent reproducibility. Ninety-two percent of repeat measures were within 10 degrees. High overall and pairwise agreement among the three observers also was present; the interobserver reliability coefficients ranged from 0.81 to 0.92. Conclusions. The measurement of lumbar lordosis is reproducible and reliable if the technique is specified and one accepts 10 degrees as acceptable variation. Factors that affect the reproducibility of measurement include end vertebra selection (especially with transitional segments) and vertebral endplate architectura. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP Polly, DW (reprint author), WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307, USA. NR 28 TC 106 Z9 109 U1 1 U2 5 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-2436 J9 SPINE JI SPINE PD JUL 1 PY 1996 VL 21 IS 13 BP 1530 EP 1535 DI 10.1097/00007632-199607010-00008 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA UV647 UT WOS:A1996UV64700008 PM 8817780 ER PT J AU Meter, JJ Polly, DW Miller, DW Popovic, NA Ondra, SL AF Meter, JJ Polly, DW Miller, DW Popovic, NA Ondra, SL TI A method for radiographic evaluation of pedicle screw violation of the vertebral endplate - Technique SO SPINE LA English DT Article DE pedicle screw; placement; vertebral end-plate ID FIXATION SYSTEM; PLACEMENT; DISK AB Study Design. This study evaluated the utility of intraoperative radiographs for minimizing the risk of pedicle screw tip violation of the superior vertebral endplate. Objectives. An intraoperative radiographic technique is demonstrated that ensures that a screw has not penetrated the intervertebral disk. Summary of Background Data. Although methods to avoid penetration of the medial pedicle cortex and the anterior body cortex have been described, no study has discussed screw penetration of the superior endplate and disc. Methods. Pedicle screws were inserted into 11 cadaveric lumbar spines, randomly, with the tip inferior to the endplate, at the endplate, and through the endplate. Radiographs were evaluated to measure the penetration, if any, of the screws. Spine segments were dissected and evaluated anatomically. The anatomic and radiographic results were then compared. Results. The overall error rate for radiographs was 22/312 (7%). Oblique radiographs gave a much higher error rate. Conclusions. A true lateral or anteroposterior radiographic view of the vertebra provides a high degree of certainty that the screw has not crossed the endplate when a ''safe zone'' of 3 mm remains superior to the screw tip. Intraoperative radiography can reduce concern about violation of the superior vertebral endplate. C1 WALTER REED ARMY MED CTR,DEPT ORTHOPAED SURG,ORTHOPAED SURG SERV,WASHINGTON,DC 20307. NR 26 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-2436 J9 SPINE JI SPINE PD JUL 1 PY 1996 VL 21 IS 13 BP 1587 EP 1592 DI 10.1097/00007632-199607010-00020 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA UV647 UT WOS:A1996UV64700020 PM 8817789 ER PT J AU Cain, BL Croisant, WJ AF Cain, BL Croisant, WJ TI Electrical contact resistance of titanium nitride coatings for electromagnetic shielding applications SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE titanium nitride; contact resistance; electromagnetic shielding; coatings AB Coating materials are typically applied to aluminum alloys, steel, and brass components used in electromagnetic shields in order to provide better corrosion and wear protection for the substrates, and to produce low contact resistance at mated contact joints. This is especially important for contacts which are periodically operated in aggressive environments, such as the doors and access panels on mobile communications facilities used by the military in the field. In this work, the contact resistance of titanium nitride (TiN) coated aluminum alloy 6061-T6, prepared using reactive ion plating, is compared to chromate conversion coated and bare aluminum alloy 6061-T6 contacts when mated to a typical electromagnetic gasket as a function of cyclic make-and-break loading of the contacts. An outline of the coating process and contact resistance test method is presented, along with details of comparative contact resistance results of the coated contacts. It is concluded that 5 mu m thick TiN coatings have significantly lower contact resistance than comparable chromate conversion coated or bare aluminum alloy 6061-T6 contacts when cycled through several thousand contact closures. C1 USA,CONSTRUCT ENGN RES LAB,EM,FMT,CHAMPAIGN,IL 61826. RP Cain, BL (reprint author), MISSISSIPPI STATE UNIV,DEPT MECH ENGN,PO DRAWER ME,MISSISSIPPI STATE,MS 39762, USA. NR 36 TC 3 Z9 3 U1 1 U2 5 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JUL PY 1996 VL 82 IS 1-2 BP 83 EP 89 DI 10.1016/0257-8972(95)02645-2 PG 7 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA UR756 UT WOS:A1996UR75600012 ER PT J AU Edstein, MD Yeo, AET Kyle, DE Looareesuwan, S Wilairatana, P Rieckmann, KH AF Edstein, MD Yeo, AET Kyle, DE Looareesuwan, S Wilairatana, P Rieckmann, KH TI Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE malaria; Plasmodium falciparum; chemotherapy; atovaquone; proguanil; genetic polymorphism ID MEPHENYTOIN OXIDATION POLYMORPHISM; METABOLITE CYCLOGUANIL; DOSE PHARMACOKINETICS; PLASMODIUM; VARIABILITY; ACTIVATION; MALARIA; CULTURE AB Clinical studies have shown proguanil (FROG) combined with atovaquone (ATQ) to be an effective and safe antimalarial combination for the treatment of multidrug-resistant falciparum malaria. FROG is a prodrug, which undergoes hepatic metabolism to its pharmacologically active metabolite cycloguanil (CYC). Individuals exhibit genetic polymorphism with respect to FROG, and can be phenotyped as either extensive metabolizers (EMs) or poor metabolizers (PMs) by measuring their PROG/CYC concentration ratio in plasma following PROG/ATQ administration. PMs produce lower plasma concentrations of CYC than EMs and thus may be more susceptible to prophylaxis or treatment failure. Both FROG and CYC potentiate the activity of ATQ in vitro. The antimalarial activity ex vivo of Thai patients' plasma samples obtained from EMs and PMs given concurrent PROC and ATQ was studied using the K1 isolate of Plasmodium falciparum This isolate is resistant to FROG and CYC, but sensitive to ATQ. Maximum inhibitory dilution profiles of the patients' plasma samples containing FROG and ATQ from EMs and PMs were similar. These findings indicate that differences in plasma drug concentrations between EMs and PMs did not alter the antimalarial activity in vitro against the K1 isolate. The phenotypic status of individuals is not an important issue in the treatment of patients with PROG/ATQ. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. MAHIDOL UNIV,FAC TROP MED,BANGKOK,THAILAND. RP Edstein, MD (reprint author), LIVERPOOL MIL AREA,ARMY MALARIA RES UNIT,SYDNEY,NSW 2174,AUSTRALIA. NR 21 TC 18 Z9 18 U1 1 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JUL-AUG PY 1996 VL 90 IS 4 BP 418 EP 421 DI 10.1016/S0035-9203(96)90531-3 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VF184 UT WOS:A1996VF18400024 PM 8882194 ER PT J AU ECHEVARRIA, AJ AF ECHEVARRIA, AJ TI BORROWING FROM THE MASTER, USES OF CLAUSEWITZ IN GERMAN MILITARY LITERATURE BEFORE THE GREAT-WAR SO WAR IN HISTORY LA English DT Article RP ECHEVARRIA, AJ (reprint author), USA,FT KNOX,KY 40121, USA. NR 84 TC 1 Z9 1 U1 0 U2 0 PU EDWARD ARNOLD PUBL LTD PI LONDON PA 338 EUSTON ROAD, LONDON, ENGLAND NW1 3BH SN 0968-3445 J9 WAR HIST JI War Hist. PD JUL PY 1996 VL 3 IS 3 BP 274 EP 292 DI 10.1177/096834459600300302 PG 19 WC History; International Relations SC History; International Relations GA UY070 UT WOS:A1996UY07000002 ER PT J AU Levine, BL Mosca, JD Riley, JL Carroll, RG Vahey, MT Jagodzinski, LL Wagner, KF Mayers, DL Burke, DS Weislow, OS StLouis, DC June, CH AF Levine, BL Mosca, JD Riley, JL Carroll, RG Vahey, MT Jagodzinski, LL Wagner, KF Mayers, DL Burke, DS Weislow, OS StLouis, DC June, CH TI Antiviral effect and ex vivo CD4(+) T cell proliferation in HIV-positive patients as a result of CD28 costimulation SO SCIENCE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; LYMPHOCYTES-T; REPLICATION; INFECTION; INDIVIDUALS; ACTIVATION; EXPRESSION; AIDS; INTERLEUKIN-2; RESPONSES AB Because stimulation of CD4(+) lymphocytes leads to activation of human immunodeficiency virus-type 1 (HIV-1) replication, viral spread, and cell death, adoptive CD4(+) T cell therapy has not been possible. When antigen and CD28 receptors on cultured T cells were stimulated by monoclonal antibodies (mAbs) to CD3 and CD28 that had been immobilized, there was an increase in the number of polyclonal CD4(+) T cells from HIV-infected donors. Activated cells predominantly secreted cytokines associated with T helper cell type 1 function, The HIV-1 viral load declined in the absence of antiretroviral agents, Moreover, CD28 stimulation of CD4(+) T cells from uninfected donors rendered these cells highly resistant to HIV-I infection, Immobilization of CD28 mAb was crucial to the development of HIV resistance, as cells stimulated with soluble CD28 mAb were highly susceptible to HIV infection, The CD28-mediated antiviral effect occurred early in the viral life cycle, before HIV-1 DNA integration. These data may facilitate immune reconstitution and gene therapy approaches in persons with HIV infection. C1 USN,MED RES INST,BETHESDA,MD 20889. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. SRA TECHNOL,DIV LIFE SCI,ROCKVILLE,MD 20850. RI Levine, Bruce/D-1688-2009; OI Riley, James/0000-0002-1057-576X; /0000-0002-5704-8094 FU NIAID NIH HHS [AI29331] NR 41 TC 183 Z9 185 U1 0 U2 2 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD JUN 28 PY 1996 VL 272 IS 5270 BP 1939 EP 1943 DI 10.1126/science.272.5270.1939 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA UV294 UT WOS:A1996UV29400049 PM 8658167 ER PT J AU Fisher, CJ Agosti, JM Opal, SM Lowry, SF Balk, RA Sadoff, JC Abraham, E Schein, RMH Benjamin, E AF Fisher, CJ Agosti, JM Opal, SM Lowry, SF Balk, RA Sadoff, JC Abraham, E Schein, RMH Benjamin, E TI Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID FACTOR-BINDING-PROTEIN; FACTOR-ALPHA; MONOCLONAL-ANTIBODY; SEPSIS SYNDROME; CANCER-PATIENTS; TNF-ALPHA; SERUM; CACHECTIN; INTERLEUKIN-1; ENDOTOXIN AB Background, A recombinant, soluble fusion protein that is a dimer of an extracellular portion of the human tumor necrosis factor (TNF) receptor and the Fc portion of IgG1 (TNFR:Fc) binds and neutralizes TNF-alpha and prevents death in animal models of bacteremia and endotoxemia. Methods. To evaluate the safety and efficacy of TNFR:Fc in the treatment of septic shock, we conducted a randomized, double-blind, placebo-controlled, multicenter trial. A total of 141 patients were randomly assigned to receive either placebo or a single intravenous infusion of one of three doses of TNFR:Fc (0.15, 0.45, or 1.5 mg per kilogram of body weight). The primary end point was mortality from all causes at 28 days. Results. There were 10 deaths among the 33 patients in the placebo group (30 percent mortality), 9 deaths among the 30 patients receiving the low dose of TNFR:Fc (30 percent mortality), 14 deaths among the 29 receiving the middle dose (48 percent mortality), and 26 deaths among the 49 receiving the high dose (53 percent mortality) (P=0.02 for the dose-response relation). Baseline differences in the severity of illness did not account for the increased mortality in the groups receiving the higher doses of TNFR:Fc. Conclusions. In patients with septic shock, treatment with the TNFR:Fc fusion protein does not reduce mortality, and higher doses appear to be associated with increased mortality. (C) 1996, Massachusetts Medical Society. C1 IMMUNEX CORP,DIV RES & DEV,SEATTLE,WA. BROWN UNIV,SCH MED,DEPT MED,PAWTUCKET,RI. BROWN UNIV,MEM HOSP RHODE ISL,PAWTUCKET,RI 02860. CORNELL UNIV,MED CTR,DEPT SURG,NEW YORK,NY 10021. RUSH PRESBYTERIAN ST LUKES MED CTR,SECT PULM,CHICAGO,IL 60612. RUSH PRESBYTERIAN ST LUKES MED CTR,SECT CRIT CARE MED,CHICAGO,IL 60612. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. UNIV CALIF LOS ANGELES,DEPT MED,LOS ANGELES,CA 90024. VET AFFAIRS MED CTR,MIAMI,FL 33125. UNIV MIAMI,DEPT MED,MIAMI,FL. MT SINAI MED CTR,DEPT SURG,NEW YORK,NY 10029. RP Fisher, CJ (reprint author), CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,CRIT CARE RES UNIT,MAIL CODE G-62,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. NR 57 TC 762 Z9 781 U1 0 U2 16 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 27 PY 1996 VL 334 IS 26 BP 1697 EP 1702 DI 10.1056/NEJM199606273342603 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA UT400 UT WOS:A1996UT40000003 PM 8637514 ER PT J AU Guha, S Roberts, WT Ahn, BH AF Guha, S Roberts, WT Ahn, BH TI Nonlinear optical limiting of C-60, platinum poly-yne, and tetrabenzporphyrin in the near infrared SO APPLIED PHYSICS LETTERS LA English DT Article ID ABSORPTION; 3RD-ORDER AB Nonlinear optical Limiting behavior of carbon 60 (C-60), platinum poly-yne (PPY), and tetrabenzporphyrin (TBP) was evaluated using lasers with mu s and ns pulse widths at the wavelength of 750 nm in an f/5 optical setup. PPY had the lowest clamping level for ns pulses, and TBP hail the lowest clamping level for mu s pulses. Possible explanations for nonlinear optical behavior are provided. (C) 1996 American Institute of Physics. C1 USA,NVESD,FT BELVOIR,VA 22060. E OIR MEASUREMENTS INC,SPOTSYLVANIA,VA 22553. NR 9 TC 12 Z9 12 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 24 PY 1996 VL 68 IS 26 BP 3686 EP 3688 DI 10.1063/1.115743 PG 3 WC Physics, Applied SC Physics GA UT481 UT WOS:A1996UT48100004 ER PT J AU McLane, GF Flemish, JR AF McLane, GF Flemish, JR TI High etch rates of SiC in magnetron enhanced SF6 plasmas SO APPLIED PHYSICS LETTERS LA English DT Article ID FLUORINATED GASES; SILICON-CARBIDE; THIN-FILMS; ION; MIXTURES; GAAS AB Magnetron enhanced reactive ion etching of SIC has been investigated in SF6 plasmas. Etch rate was determined as a function of cathode power density (0.1-0.5 W/cm(2)), pressure (1-5 mTorr), and flow rate (5-15 sccm). The highest SIC etch rates yet reported (450 nm/min) were achieved, at low cathode bias voltage (100 V). Anisotropic etch profiles were obtained with smooth etch surfaces free of micromasking. Addition of O-2 to the SF6 feed gas did not increase the etch rate. RP McLane, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 22 TC 26 Z9 26 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 24 PY 1996 VL 68 IS 26 BP 3755 EP 3757 DI 10.1063/1.115996 PG 3 WC Physics, Applied SC Physics GA UT481 UT WOS:A1996UT48100027 ER PT J AU Washington, GE AF Washington, GE TI An exactly solvable model for the collapsed state of Gaussian polymer chains (vol 104, pg 7284 1996) SO JOURNAL OF CHEMICAL PHYSICS LA English DT Correction, Addition RP Washington, GE (reprint author), USMA,DEPT CHEM,W POINT,NY 10966, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 22 PY 1996 VL 104 IS 24 BP 10064 EP 10064 DI 10.1063/1.471830 PG 1 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA UR692 UT WOS:A1996UR69200046 ER PT J AU Emanuel, P OBrien, T Burans, J DasGupta, BR Valdes, JJ Eldefrawi, M AF Emanuel, P OBrien, T Burans, J DasGupta, BR Valdes, JJ Eldefrawi, M TI Directing antigen specificity towards botulinum neurotoxin with combinatorial phage display libraries SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE phage display; Fab fragment; monoclonal antibody; botulinum toxin ID MONOCLONAL-ANTIBODIES; FILAMENTOUS PHAGE; ESCHERICHIA-COLI; CLONING; FRAGMENTS; LAMBDA; GENES; PURIFICATION; GENERATION; REPERTOIRE AB The production of antibodies towards antigens with low immunogenicity is enhanced by the intrinsic efficiency of screening combinatorial libraries of immunoglobulins. The need to isolate clones with rare binding specificities has dictated a highly efficient method of screening and isolating antibody clones. The production of recombinant immunoglobulin libraries in bacteria allows for a more controlled selection of antibody specificity and can be used in circumstances where hybridoma fusions are unable to isolate rare clones with the desired epitope specificity. Botulinum neurotoxin (NT) with associated non neurotoxin proteins (non-NT) as a complex was used to immunize mice to obtain mRNA for the production of a recombinant antibody library with a repertoire of specificities. Initial screens of the combinatorial library revealed clones which recognized the non-neurotoxin proteins of the toxin complex similar to monoclonal antibodies produced by conventional hybridoma fusions. The combinatorial library was re-screened in order to isolate antibodies that specifically recognized the neurotoxin component of the toxin complex. The ability to alter the biopanning selection process affords the researcher a measure of control in the selection process not available with traditional hybridoma fusions. C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,RES DEV & ENGN CTR,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. USN,MED RES INST,BETHESDA,MD 20889. UNIV WISCONSIN,DEPT FOOD MICROBIOL & TOXICOL,MADISON,WI 53706. FU NINDS NIH HHS [NS 17742] NR 34 TC 24 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUN 21 PY 1996 VL 193 IS 2 BP 189 EP 197 DI 10.1016/0022-1759(96)00053-1 PG 9 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA UV325 UT WOS:A1996UV32500006 PM 8699032 ER PT J AU Xu, J Gross, RA Kaplan, DL Swift, G AF Xu, J Gross, RA Kaplan, DL Swift, G TI Chemoenzymatic synthesis and study of poly(alpha-methyl-beta-propiolactone) stereocopolymers SO MACROMOLECULES LA English DT Article ID SUBSTITUTED BETA-PROPIOLACTONES; ORGANIC-SOLVENTS; ENZYMATIC RESOLUTION; QUANTITATIVE-ANALYSES; LIVER ESTERASE; POLYMERIZATION; LACTONES; POLY(BETA-HYDROXYBUTYRATE); LACTONIZATION; HYDROXYESTERS AB A chemoenzymatic route from racemic alpha-methyl-beta-propiolactone (MPL) to optically active (R)-poly(alpha-methyl-beta-propiolactone), (R)-PMPL, was demonstrated which involved lipase catalyzed resolution of MPL enantiomers in organic media and subsequent chemical polymerization. From a comparative study of different enzymes and organic media, catalysis by the lipase PS-30 from Pseudomonas fluorescens suspended in diethyl ether was found to be most suitable for MPL enantioselective alcoholysis reactions. MPL having up to 93% (R) content was thus obtained, mixed in various proportions with racemic MPL, and polymerized using CH3COOK/dibenzo-18-crown-6. From a plot of specific rotation vs % enantiopurity, it was estimated that the [alpha]D-25 for 100% (R)-PMPL is -38.4 degrees (c 0.8 g/dL, CHCl3). C-13 NMR LR analysis (62.9 MHz) provided information on triad sequence distributions from observation of methine carbons, while the methyl and carbonyl carbons were sensitive to diad sequences. The polymerization of 50% (R)-MPL followed Bernoulli random chain propagation statistics. In contrast, polymerizations of 74% and 93% (R)-MPL deviated from the Bernoulli model. Further analysis showed that these latter polymerizations fit the enantiomorphic-site model. Thus, isoregulating characteristics of the CH3COOK/dibenzo-18-crown-6 catalyst for enantioenriched MPL polymerizations were demonstrated. By increasing the % (R)-content in the monomer feed to 93%, a product was obtained which, by DSC, had T-m and Delta H-f values of 131 degrees C and 22.0 cal/g, respectively. Furthermore, WAXS analysis carried out on a melt-annealed 90% (R)-PMPL sample showed that the polymer was highly crystalline (approximately 73%). FTIR analysis was used to identify vibrational bands at 997, 1010, 1059, 1185, 1249, and 1334 cm(-1) which were crystalline-sensitive, while the band at 1465 cm(-1) was crystalline-insensitive. C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. USA,STRNC YM,DIV BIOTECHNOL,RD&E CTR,NATICK,MA 01760. ROHM & HAAS CO,SPRING HOUSE,PA 19477. NR 45 TC 15 Z9 16 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUN 17 PY 1996 VL 29 IS 13 BP 4582 EP 4590 DI 10.1021/ma951869i PG 9 WC Polymer Science SC Polymer Science GA UT135 UT WOS:A1996UT13500018 ER PT J AU Svirkin, YY Xu, J Gross, RA Kaplan, DL Swift, G AF Svirkin, YY Xu, J Gross, RA Kaplan, DL Swift, G TI Enzyme-catalyzed stereoelective ring-opening polymerization of alpha-methyl-beta-propiolactone SO MACROMOLECULES LA English DT Article ID ORGANIC-SOLVENTS; STEREOCHEMICAL CONTROL; EPSILON-CAPROLACTONE; PROPYLENE; POLYMERS; LIPASE AB The lipase-catalyzed stereoelective ring-opening polymerization of racemic alpha-methyl-beta-propiolactone (MPL) was investigated. Using the lipase PS-30 from Pseudomonas fluorescens, a direct route to optically active (S)-enriched poly(alpha-methyl-beta-propiolactone), PMPL, was demonstrated. From a comparative study of different organic media, polymerizations conducted in toluene and heptane proceeded more rapidly than those carried out in dioxane. The enantiomeric ratios E in toluene, heptane, and dioxane were 4.1 +/- 0.2, 0.9, and 2.0, respectively. Thus, from the point of view of reaction rates and enantioselectivity, toluene was found to be the preferred solvent. PMPL products prepared in toluene by PS-30 catalysis had M(n) values from 2600 to 2900 g/mol and [alpha]D-25 + 12.2 degrees to + 19.0 degrees (c 0.9 g/dL, CHCl3). Analysis of the polymer chain end structure by H-1 and C-13 NMR showed that these products have hydroxyl and carboxylic acid termini. Based on the analysis of chain stereosequence distributions by C-13 NMR, it was concluded that stereoselectivity during propagation results from catalyst enantiomorphic-site control. Investigation of the thermal behavior of PMPL (75% (S)) by DSC showed that melting occurs over abroad region from similar to 25 to 100 degrees C where the total Delta H-f is 12.7 cal/g. C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. USA,STRNC YM,DIV BIOTECHNOL,RD&E CTR,NATICK,MA 01760. ROHM & HAAS CO,SPRING HOUSE,PA 19477. NR 29 TC 95 Z9 100 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUN 17 PY 1996 VL 29 IS 13 BP 4591 EP 4597 DI 10.1021/ma951868q PG 7 WC Polymer Science SC Polymer Science GA UT135 UT WOS:A1996UT13500019 ER PT J AU McBride, CE Yavorski, RT Moses, FM Robson, ME Solimando, DA Byrd, JC AF McBride, CE Yavorski, RT Moses, FM Robson, ME Solimando, DA Byrd, JC TI Acute pancreatitis associated with continuous infusion cytarabine therapy - A case report SO CANCER LA English DT Article DE pancreatitis; cytarabine; acute myelogenous leukemia; high dose cytarabine; etoposide; mitoxantronen ID DRUG-INDUCED PANCREATITIS; CYTOSINE-ARABINOSIDE; LEUKEMIA AB BACKGROUND. While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported io the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complicated by comorbid illnesses and the coadministration of other drugs associated with acute pancreatitis. METHODS. This report describes the clinical course of a patient with acute myelogenous leukemia (AML) who developed recurrent pancreatitis associated with cytarabine therapy. RESULTS. A male age 36 years with French-American-British M5B acute myelogenous leukemia received induction cytarabine (200 mg/m(2)/day) by continuous infusion for days, and subsequently developed acute pancreatitis. The patient was rechallenged with intermittent, bolus, high dose cytarabine (HDAC) (3 g/m(2)bid administered over 3 hours) during the following intensification treatment, but did not develop clinical acute pancreatitis. Retreatment with continuous infusion cytarabine at a later time resulted in recurrence of acute pancreatitis. CONCLUSIONS. This case illustrates that cytarabine treatment may cause acute pancreatitis, and that this toxicity may be schedule dependent. In those with known sensitivity to cytarabine, altering the administration technique may avoid this complication. (C) 1996 American Cancer Society. C1 WALTER REED ARMY MED CTR,DEPT MED,DIV GASTROENTEROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,DIV HEMATOL ONCOL,WASHINGTON,DC 20307. NR 17 TC 3 Z9 3 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUN 15 PY 1996 VL 77 IS 12 BP 2588 EP 2591 DI 10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-CNCR24>3.0.CO;2-N PG 4 WC Oncology SC Oncology GA UN538 UT WOS:A1996UN53800024 PM 8640710 ER PT J AU Mitin, VV Paulavicius, G Bannov, NA Stroscio, MA AF Mitin, VV Paulavicius, G Bannov, NA Stroscio, MA TI Radiation patterns of acoustic phonons emitted by hot electrons in a quantum well SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID QUANTIZING MAGNETIC-FIELD; EMISSION; GAS AB The acoustic phonon radiation patterns and acoustic phonon spectra due to electron-acoustic-phonon interaction in a double barrier quantum well have been investigated by solving both the kinetic equations for electrons and phonons. The acoustic phonon radiation patterns have strongly pronounced maximum in the directions close to the perpendicular to the quantum well direction. The radiation pattern anisotropy is explained in terms of possible electron transitions, electron distribution function, and the Hamiltonian of electron-phonon interaction. It was shown that, the simple assumption that emitted phonons always have a perpendicular wave-vector component of the order of 2 pi/a, where a is the width of the quantum well, cannot explain the strong anisotropy of the radiation patterns. More detailed analysis is required and has been carried out. The emitted acoustic phonon spectra have maxima at energies 2 pi HBARu/a, where u is the sound velocity. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Mitin, VV (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 24 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 1996 VL 79 IS 12 BP 8955 EP 8963 DI 10.1063/1.362627 PG 9 WC Physics, Applied SC Physics GA UT341 UT WOS:A1996UT34100013 ER PT J AU Dzwinel, W Alda, W Kitowski, J Moscinski, J Yuen, DA AF Dzwinel, W Alda, W Kitowski, J Moscinski, J Yuen, DA TI An examination of long-rod penetration in micro-scale using particles SO JOURNAL OF MATERIALS PROCESSING TECHNOLOGY LA English DT Article; Proceedings Paper CT 6th International Conference on Metal Forming CY JUN 23-26, 1996 CL AKADEMIA GORNICZO HUTNICZA, KRAKOW, POLAND SP Akad Gorniczo Hutnicza, Univ Birmingham HO AKADEMIA GORNICZO HUTNICZA DE long rod penetration; computer simulation using particles; micro-scale; molecular dynamics; brittle materials AB The authors show how using particle simulations one can try to solve the problems out of reach of classical models based on the matter, momenta and energy flows continuity. Being aware about limitations of the method applied, the paper presents the perspectives of particle based simulations considering as an example the penetration mechanism investigation in micro-scale. C1 AGH UNIV SCI & TECHNOL, ACAD COMP CTR CYFRONET, PL-30950 KRAKOW, POLAND. MINNESOTA SUPERCOMP INST, DEPT GEOL & GEOPHYS, MINNEAPOLIS, MN USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55415 USA. RP Dzwinel, W (reprint author), AGH UNIV SCI & TECHNOL, INST COMP SCI, AL MICKIEWICZA 30, PL-30059 KRAKOW, POLAND. RI Dzwinel, Witold/C-3872-2008; Kitowski, Jacek/D-1107-2017 OI Kitowski, Jacek/0000-0003-3902-8310 NR 14 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-0136 J9 J MATER PROCESS TECH JI J. Mater. Process. Technol. PD JUN 15 PY 1996 VL 60 IS 1-4 BP 415 EP 420 DI 10.1016/0924-0136(96)02364-3 PG 6 WC Engineering, Industrial; Engineering, Manufacturing; Materials Science, Multidisciplinary SC Engineering; Materials Science GA UT573 UT WOS:A1996UT57300066 ER PT J AU Rao, DVGLN Aranda, FJ Rao, DN Chen, Z Akkara, JA Kaplan, DL Nakashima, M AF Rao, DVGLN Aranda, FJ Rao, DN Chen, Z Akkara, JA Kaplan, DL Nakashima, M TI All-optical logic gates with bacteriorhodopsin films SO OPTICS COMMUNICATIONS LA English DT Article AB We demonstrate an all-optical switch using molecular states in a bacteriorhodopsin (bR) thin film. All-optical logic gates are implemented with wild-type and chemically stabilized films of bacteriorhodopsin using a two-color backward degenerate four-wave mixing geometry. The films are observed to be stable over a period of four years. The sensitivity of each bR film is markedly different due to the large differences in the saturation intensity which can be controlled by different means. Red light is used to form a grating due to the B to M transition and blue light is used to form a grating due to the fast photochemical transition from M to B. Each of the two wavelengths in the experimental system acts as an input to the all-optical gate and the phase conjugate signal beam bears the output of the gate. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. UNIV HYDERABAD,SCH PHYS,HYDERABAD 500134,ANDHRA PRADESH,INDIA. RP Rao, DVGLN (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 24 TC 46 Z9 48 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUN 15 PY 1996 VL 127 IS 4-6 BP 193 EP 199 DI 10.1016/0030-4018(96)00180-0 PG 7 WC Optics SC Optics GA UU414 UT WOS:A1996UU41400005 ER PT J AU Bhagwat, SV Bhamre, S Boyd, MR Ravindranath, V AF Bhagwat, SV Bhamre, S Boyd, MR Ravindranath, V TI Further characterization of rat brain flavin containing monooxygenase - Metabolism of imipramine to its N-oxide SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE brain; antidepressants; flavin-containing monooxygenase; drug metabolism; monooxygenases; psychoactive drugs ID POLYACRYLAMIDE GELS; RABBIT; PROTEINS; QUANTITATION; SPECIFICITY; PULMONARY; DISTINCT; ENZYMES; MOUSE AB Flavin containing monooxygenase (FMO) activity was compared in rat liver and brain microsomes by estimating the actual amount of imipramine N-oxide relative to the corresponding activity, measured using substrate-stimulated rates of NADPH oxidation. The activities measured as NADPH oxidation rates were significantly higher than those estimated from the N-oxide formed. The brain FMO activity was detectable only in the presence of detergents (sodium cholate or Lubrol PX) or in microsomes that were freeze-thawed several times. The antibody to rabbit pulmonary FMO selectively inhibited imipramine N-oxidation. The antiserum to the rat liver NADPH cytochrome P-450 reductase had no effect on imipramine N-oxidation, indicating the noninvolvement of cytochrome P-450 in the above metabolic pathway. A flavin-containing monooxygenase was partially purified from the rat brain microsomes using sequential chromatography on n-octylamino-Sepharose 4B, DEAE-Sephacel and 2',5'-ADP agarose. The purified FMO was resolved by SDS-PAGE into two bands (approximately 57 and 61 KDa, respectively) both of which cross-reacted with antibody to rabbit pulmonary FMO. The purified enzyme metabolized imipramine and the model substrate methimazole to their respective N-oxide and S-oxides. C1 NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROCHEM,BANGALORE 560029,KARNATAKA,INDIA. USA,DEV THERAPEUT PROGRAM,LAB DRUG DISCOVERY RES & DEV,FT DETRICK,MD 21702. NR 17 TC 9 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD JUN 14 PY 1996 VL 51 IS 11 BP 1469 EP 1475 DI 10.1016/0006-2952(96)00088-3 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UJ833 UT WOS:A1996UJ83300007 PM 8630088 ER PT J AU Mahalanobis, A Kumar, BVKV Sims, SRF AF Mahalanobis, A Kumar, BVKV Sims, SRF TI Distance-classifier correlation filters for multiclass target recognition SO APPLIED OPTICS LA English DT Article DE correlators; correlation filters; target recognition; distance classifier; shift invariance; distortion tolerance; discrimination; Fourier transforms AB We describe a correlation-based distance-classifier scheme for the recognition and the classification of multiple classes. The underlying theory uses shift-invariant filters to compute distances between the input image and ideal references under an optimum transformation. The original distance-classifier correlation filter was developed for a two-class problem. We introduce a distance-classifier correlation filter that simultaneously considers multiple classes, and we show that the earlier two-class formulation isa special case of the classifier presented. Initial results are presented to demonstrate the discrimination- and distortion-tolerance capabilities of the proposed filter. (C) 1996 Optical Society of America C1 CARNEGIE MELLON UNIV,DEPT ELECT & COMP ENGN,PITTSBURGH,PA 15213. USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP Mahalanobis, A (reprint author), HUGHES MISSILE SYST CO,BLDG 805,MAIL STOP F3,POB 11337,TUCSON,AZ 85734, USA. NR 15 TC 82 Z9 83 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 1996 VL 35 IS 17 BP 3127 EP 3133 DI 10.1364/AO.35.003127 PG 7 WC Optics SC Optics GA UT067 UT WOS:A1996UT06700008 PM 21102690 ER PT J AU Cavus, A Zeng, L Tamargo, MC Bambha, N Semendy, F Gray, A AF Cavus, A Zeng, L Tamargo, MC Bambha, N Semendy, F Gray, A TI ZnCdSe/ZnCdMgSe quantum wells on InP substrates for visible emitters SO APPLIED PHYSICS LETTERS LA English DT Article ID GREEN LASER-DIODES; INJECTION-LASERS AB We have grown ZnCdSe/ZnCdMgSe quantum well (QW) structures nearly lattice matched to InP substrates. Emission energies from 2.307 to 2.960 eV were measured by low-temperature photoluminescence at 10 K for samples with QW thicknesses between 5 and 80 Angstrom. By using exactly lattice-matched QWs, the lower limit of the energy range call be lowered to about 2.2 eV (at 10 K). We propose that these structures could be used in entirety lattice-matched semiconductor lasers operating at room temperature in the blue, green, and yellow regions. Because of the absence of strain, these materials are expected to be less prone to degradation than the current blue-green lasers grown on GaAs. (C) 1996 American Institute of Physics. C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. USA,RES LAB,IR OPT TECHNOL OFS,FT BELVOIR,VA 22060. RP Cavus, A (reprint author), CUNY CITY COLL,NEW YORK STATE CTR ADV TECHNOL ULTRAFAST PHOTON M,CTR ANAL STRUCT & INTERFACES,NEW YORK,NY 10031, USA. NR 15 TC 38 Z9 38 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 10 PY 1996 VL 68 IS 24 BP 3446 EP 3448 DI 10.1063/1.115788 PG 3 WC Physics, Applied SC Physics GA UQ189 UT WOS:A1996UQ18900026 ER PT J AU Tyan, SL Wang, YC Hwang, JS Shen, H AF Tyan, SL Wang, YC Hwang, JS Shen, H TI Unambiguous photoreflectance determination of electric fields using phase suppression SO APPLIED PHYSICS LETTERS LA English DT Article ID HETEROSTRUCTURES AB Photoreflectance measurements have been performed on a delta-doped GaAs homojunction, Two Franz-Kelysh oscillation features originating from two different regions (a buffer layer and a top layer) of the structure superimpose with each other in the photoreflectance spectrum. By properly selecting the reference phase, one of the features can be suppressed, thus enabling us to determine the electric fields from the two regions unambiguously. The electric field in the top layer is 3.5 +/- 0.2 x 10(5) V/cm, which is in good agreement with theoretical calculation. The electric field in the buffer layer is 1.2 +/- 0.1 x 10(4) V/cm. (C) 1996 American Institute of Physics. C1 USA,RES LAB,PHYS SCI DIRECTORATE,AMSRL PS PB,FT MONMOUTH,NJ 07703. CHINESE MIL ACAD,DEPT CHEM & PHYS,FENGSHAN,TAIWAN. RP Tyan, SL (reprint author), NATL CHENG KUNG UNIV,DEPT PHYS,TAINAN,TAIWAN. NR 12 TC 6 Z9 6 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 10 PY 1996 VL 68 IS 24 BP 3452 EP 3454 DI 10.1063/1.115790 PG 3 WC Physics, Applied SC Physics GA UQ189 UT WOS:A1996UQ18900028 ER PT J AU Kozikowski, AP Campiani, G Nacci, V Sega, A Saxena, A Doctor, BP AF Kozikowski, AP Campiani, G Nacci, V Sega, A Saxena, A Doctor, BP TI An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity SO JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 LA English DT Article ID ACETYLCHOLINESTERASE; REAGENT AB Synthetic approaches to the pyrimidone and the pyrazole analogues of the naturally occurring acetylcholinesterase (AChE) inhibitor huperzine A and its unnatural regioisomer, isohuperzine, are described, The pyrimidone analogues of huperzine A were obtained starting from cyclohexane-1,4-dione monoethylene ketal by first annealing to this monocycle a pyrimidine ring and then constructing the unsaturated three-carbon bridge using the previously described palladium-catalysed bicycloannulation methodology, A major problem in this synthetic undertaking proved to be introduction of the ethylidene appendage onto tricycle 10, While both Wittig and Takai olefination protocols proved unsuccessful, the ethylidene moiety was eventually introduced using the Danheiser methodology which involves a two step reaction sequence consisting of the intermediate construction of a beta-lactone, which in turn undergoes a [2 + 2] cycloreversion leading to the desired olefin. This beta-lactone synthesis, which has not-previously been applied to beta-keto esters, was found to proceed with excellent diastereoselectivity. In turn, the beta-lactone underwent a stereospecific decarboxylation reaction to provide the E-olefin product as the sole isomer. Additionally, starting from the bicycle[3.3.1] nonene intermediate 2 we describe a synthetic strategy for procuring modified heterocyclic analogues of isohuperzine A. This chemistry provides an attractive approach to the synthesis of heterocyclic analogues with unsaturation in the 6,7 position. While none of these new analogues was found to rival huperzine A in its ability to act as a reversible inhibitor of AChE, the data reported herein should prove useful to modeling efforts aimed at acquiring a better understanding of huperzine A's binding topography within AChE. C1 UNIV SIENA,DIPARTIMENTO FARMACO CHIM TECNOL,I-53100 SIENA,ITALY. UNIV SIENA,INST CHIM ORGAN,I-53100 SIENA,ITALY. WALTER REED ARMY MED CTR,DIV BIOCHEM,RES INST,WASHINGTON,DC 20307. RP Kozikowski, AP (reprint author), GEORGETOWN UNIV,MED CTR,INST COGNIT & COMPUTAT SCI,WASHINGTON,DC 20007, USA. NR 38 TC 23 Z9 23 U1 0 U2 4 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF SN 0300-922X J9 J CHEM SOC PERK T 1 JI J. Chem. Soc.-Perkin Trans. 1 PD JUN 7 PY 1996 IS 11 BP 1287 EP 1297 DI 10.1039/p19960001287 PG 11 WC Chemistry, Organic SC Chemistry GA UQ520 UT WOS:A1996UQ52000026 ER PT J AU Wilson, BW Padilla, S Henderson, JD Brimijoin, S Dass, PD Elliot, G Jaeger, B Lanz, D Pearson, R Spies, R AF Wilson, BW Padilla, S Henderson, JD Brimijoin, S Dass, PD Elliot, G Jaeger, B Lanz, D Pearson, R Spies, R TI Factors in standardizing automated cholinesterase assays SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID SPECTROPHOTOMETRIC METHOD; RADIOMETRIC ASSAY; WHOLE-BLOOD AB A scientific panel assembled by the U.S. Environmental Protection Agency (EPA) determined that variability in cholinesterase (ChE) activities in the agency's pesticide/animal study database likely was due to a lack of accepted guidelines for ChE methodology. A series of trials was held in which participating laboratories measured ChE activity in blood and brain samples from untreated and pesticide-treated rats using a colorimetric assay method. The degree of inhibition of ChE activity in plasma and brain samples compared to controls was consistent among most of the laboratories. The ChE activity in erythrocyte samples differed more between laboratories due to a high blank, low erythrocyte AChE activity and hemoglobin absorption at the wavelength of the assay. Strategies are suggested for minimizing the variability of ChE activity in hemoglobin-rich samples. C1 UNIV CALIF DAVIS,DEPT ENVIRONM TOXICOL,DAVIS,CA 95616. US EPA,DIV NEUROTOXICOL,RES TRIANGLE PK,NC 27711. MAYO CLIN,ROCHESTER,MN. MILES INC,DIV AGR,STILWELL,KS. DUPONT HASKELL LAB TOXICOL & IND MED,NEWARK,DE. US EPA,WASHINGTON,DC 20460. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. CORNING HAZLETON INC,VIENNA,VA. PHARMACO LSR,E MILLSTONE,NJ. RP Wilson, BW (reprint author), UNIV CALIF DAVIS,DEPT AVIAN SCI,DAVIS,CA 95616, USA. FU NIEHS NIH HHS [P30-ES-05707] NR 22 TC 37 Z9 37 U1 2 U2 6 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD JUN 7 PY 1996 VL 48 IS 2 BP 187 EP 195 DI 10.1080/009841096161429 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA UQ875 UT WOS:A1996UQ87500007 PM 8642625 ER PT J AU Howell, T AF Howell, T TI RC receiver hosts two independent switches SO EDN LA English DT Article RP Howell, T (reprint author), USA,ARDEC,PICATINNY ARSENAL,DOVER,NJ 07801, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS-DENVER PUBLISHING CO PI HIGHLANDS RANCH PA 8773 S RIDGELINE BLVD, HIGHLANDS RANCH, CO 80126-2329 SN 0012-7515 J9 EDN JI EDN PD JUN 6 PY 1996 VL 41 IS 12 BP 118 EP & PG 2 WC Engineering, Electrical & Electronic SC Engineering GA UQ989 UT WOS:A1996UQ98900032 ER PT J AU McDonald, L AF McDonald, L TI BA or ''BS''? SO FORBES LA English DT Letter RP McDonald, L (reprint author), US MIL ACAD,CLASS 1982,DENVER,CO, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FORBES INC PI NEW YORK PA 60 FIFTH AVE, NEW YORK, NY 10011 SN 0015-6914 J9 FORBES JI Forbes PD JUN 3 PY 1996 VL 157 IS 11 BP 20 EP 20 PG 1 WC Business, Finance SC Business & Economics GA UL955 UT WOS:A1996UL95500010 ER PT J AU Hayes, DP Wolfer, LT Wolfe, MF AF Hayes, DP Wolfer, LT Wolfe, MF TI Schoolbook simplification and its relation to the decline in SAT-verbal scores SO AMERICAN EDUCATIONAL RESEARCH JOURNAL LA English DT Article AB The 50+ point decline in mean SAT-verbal scores between 1963 and 1979 ir widely attributed to changes in the composition of the test-takers. Several inconsistencies in that explanation are identified. That explanation also ignores the pervasive decline in the difficulty of schoolbooks found by analyzing the texts of 800 elementary middle, and high school books published between 1919-1991. When this text simplification series is link ed to the SAT-verbal series there is a general fit for the three major periods: before, during, and after the decline. Long-term exposure to simpler texts may induce a cumulating deficit in the breadth and depth of domain-specific knowledge, lowering reading comprehension and verbal achievement. The two time series are so sufficiently linked that the cumulating knowledge deficit hypothesis may be a major explanation for the changes in verbal achievement. Only an experiment can establish whether this is causal, so we describe a simple, low-cost experiment schools can use to test how schoolbook difficulty affects their students' verbal achievement levels. C1 USA,WASHINGTON,DC 20310. RP Hayes, DP (reprint author), CORNELL UNIV,URIS HALL,ROOM 346,ITHACA,NY 14853, USA. NR 28 TC 27 Z9 27 U1 0 U2 0 PU AMER EDUCATIONAL RESEARCH ASSOC PI WASHINGTON PA 1230 17TH ST NW, WASHINGTON, DC 20036-3078 SN 0002-8312 J9 AM EDUC RES J JI Am. Educ. Res. J. PD SUM PY 1996 VL 33 IS 2 BP 489 EP 508 DI 10.3102/00028312033002489 PG 20 WC Education & Educational Research SC Education & Educational Research GA VG878 UT WOS:A1996VG87800009 ER PT J AU Wong, RKH Maydonovitch, C AF Wong, RKH Maydonovitch, C TI Utility of parameters measured during pneumatic dilation as predictors of successful dilation SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID ESOPHAGEAL ACHALASIA; DILATATION; ESOPHAGOMYOTOMY AB Objectives: The ability to immediately predict the long term outcome of a pneumatic dilation in achalasia has not been well studied. This study prospectively compared immediate postpneumatic dilation parameters with long term efficacy to determine if any factors predicted a favorable long term outcome. Methods: Twenty-nine previously undilated achalasia patients underwent graduated pneumatic dilation with Hurst-Tucker dilators (diameters 2.7, 3.3, 3.7, and 4.1 cm). Dilations began with the smallest dilator followed by an observation period of at least 6 wk to determine clinical response. If no clinical improvement was noted, the next size dilator was used. Immediate postdilation parameters studies included: 1) severity of pain during dilation, 2) amount of blood on the dilator, 3) insufflation pressures during dilation, 4) esophageal emptying of gastrograffin (30 ml), and 5) esophageal emptying of barium sulfate (90 ml). Results: None of the postdilation parameters studied predicted which patients would have good long term results. Pain during dilation increased with increasing dilator size. Conclusions: The degree of pain associated with a pneumatic dilation, the amount of blood noted on the dilator, the difference in pressure required to inflate the dilator at the beginning versus the end of dilation, and the amount of esophageal emptying immediately postdilation did not predict long term outcome. RP Wong, RKH (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,DEPT MED,WASHINGTON,DC 20305, USA. NR 13 TC 11 Z9 11 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JUN PY 1996 VL 91 IS 6 BP 1126 EP 1129 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UP420 UT WOS:A1996UP42000010 PM 8651157 ER PT J AU McCarroll, JE Fullerton, CS Ursano, RJ Hermsen, JM AF McCarroll, JE Fullerton, CS Ursano, RJ Hermsen, JM TI Posttraumatic stress symptoms following forensic dental identification: Mt Carmel, Waco, Texas SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID DISASTER; VICTIMS AB Objective: This study was conducted to determine risk factors for posttraumatic stress in medical care professionals who perform postmortem identifications. Method: Thirty-one dentists (29 men and two women) who had identified the dead from the fire at the Branch Davidian compound in April 1993 were compared to 47 dentists (45 men and two women) who lived in the area but had not identified any of these remains. Posttraumatic symptoms in both groups were measured by using the Impact of Event Scale and the Brief Symptom Inventory. For the remains handlers only, the subjective distress of handling remains and the social support received during the procedure were reported. Results: Higher scores on the Impact of Event Scale intrusion subscale, the overall Impact of Event Scale, and the obsessive-compulsive subscale of the Brief Symptom Inventory were found for the remains handlers than for the comparison group. Within the remains handler group, distress was significantly related to the hours of exposure to the remains, prior experience handling remains, age, and the support received from spouses and co-workers during the identifications. Conclusions: Posttraumatic stress symptoms can be expected in some health professionals who perform postmortem identifications. Prior experience and social support may mitigate some of these responses. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,BETHESDA,MD 20814. UNIV MARYLAND,DEPT SOCIOL,COLLEGE PK,MD 20742. NR 21 TC 48 Z9 48 U1 0 U2 1 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD JUN PY 1996 VL 153 IS 6 BP 778 EP 782 PG 5 WC Psychiatry SC Psychiatry GA UN632 UT WOS:A1996UN63200007 PM 8633689 ER PT J AU Balaraman, V Sood, SL Finn, KC Hashiro, G Uyehara, CFT Easa, D AF Balaraman, V Sood, SL Finn, KC Hashiro, G Uyehara, CFT Easa, D TI Physiologic response and lung distribution of lavage versus bolus Exosurf(R) in piglets with acute lung injury SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article ID RESPIRATORY-DISTRESS SYNDROME; EXOGENOUS SURFACTANT; PULMONARY CIRCULATION; FAILURE; RABBITS; ABNORMALITIES; INSTILLATION; VOLUME; SHEEP; LIFE AB Despite evidence of surfactant dysfunction in the acute respiratory distress syndrome (ARDS), treatment with exogenous surfactant remains experimental. Uneven pulmonary distribution is one factor that may limit response. We investigated whether exogenous surfactant administered by lavage, consisting of a 35 ml/kg volume instilled by gravity and followed immediately by passive drainage (LAVAGE), would result in better lung distribution and physiologic response than with surfactant administered as a 5 ml/kg bolus (BOLUS). Exosurf(R), an artificial surfactant, was administered after acute lung injury induced by saline lung lavage in neonatal piglets. In the LAVAGE group (n = 9), 10.1 +/- 0.4 ml/kg of surfactant was retained, corresponding to a phospholipid dose of 136 +/- 5 mg/kg. In the BOLUS group (n = 9), the dose administered was 203 mg/kg phospholipid. Piglets in the LAVAGE group demonstrated greater improvement in pulmonary function, including Pa-O2, Pa-CO2, ventilation efficiency index, functional residual capacity (FRC), and pressure-volume curves than piglets in the BOLUS group. Some differences were found in lung distribution of surfactant. We conclude that Exosurf is more effective when administered by lavage in this lung injury model. We speculate that the lavage method of administration holds promise as an alternative method of surfactant administration in patients with ARDS. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. NR 34 TC 38 Z9 39 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JUN PY 1996 VL 153 IS 6 BP 1838 EP 1843 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UR223 UT WOS:A1996UR22300015 PM 8665043 ER PT J AU Corwin, AL Khiem, HB Clayson, ET Sac, PK Nhung, VTT Yen, VT Cuc, CTT Vaughn, D Merven, J Richie, TL Putri, MP He, JK Graham, R Wignall, FS Hyams, KC AF Corwin, AL Khiem, HB Clayson, ET Sac, PK Nhung, VTT Yen, VT Cuc, CTT Vaughn, D Merven, J Richie, TL Putri, MP He, JK Graham, R Wignall, FS Hyams, KC TI A waterborne outbreak of hepatitis E virus transmission in southwestern Vietnam SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EPIDEMIOLOGY AB A hepatitis outbreak affecting primarily adults occurred in southwestern Vietnam, along the Hau river bordering Cambodia, in June and July 1994. One month after the outbreak, sera and epidemiologic information were collected from 150 subjects: 50 patient cases, 50 matched, healthy community controls, and 50 geographic controls living 50 km upriver. The prevalence of immunoglobulin G (IgG) to hepatitis E virus (HEV) was significantly (P < 0.001) higher (76%) among cases than among the matched (38%), and geographic (38%) control populations. Immunoglobulin M to HEV was detected by enzyme-linked immunosorbent assay and Western blot in 16% of sera collected from patients one month after the outbreak. Hepatitis E virus RNA was detected with the polymerase chain reaction in 6% of sera from patients; RNA was not detected in either control group. These results indicate that HEV was the etiologic agent responsible for the outbreak. Children were under-represented among clinical cases. River water served as the principal source for drinking and bathing among most (96%) of the case and control study populations. Boiling of drinking water was negatively associated (P < 0.05) with IgG anti-HEV seropositivity. Unusually heavy rainfall likely contributed to conditions that favored the outbreak. This is the first recognized outbreak of epidemic HEV transmission in Indo-China. C1 USN, MED RES UNIT 2, JAKARTA 10400, INDONESIA. INST PASTEUR, HO CHI MINH CITY, VIETNAM. ARMED FORCES RES INST MED SCI, BANGKOK, THAILAND. USN, MED RES INST, BETHESDA, MD USA. NR 13 TC 59 Z9 62 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1996 VL 54 IS 6 BP 559 EP 562 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA UX379 UT WOS:A1996UX37900003 PM 8686771 ER PT J AU Klotz, FW Cohen, SJ Szarfman, A Aikawa, M Howard, RJ AF Klotz, FW Cohen, SJ Szarfman, A Aikawa, M Howard, RJ TI Cross-reactive epitope among proteins in Plasmodium falciparum Maurer's clefts and primate leukocytes and platelets SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTED ERYTHROCYTES; THAI PATIENTS; LIVER STAGES; MALARIA; MEMBRANE; ANTIBODY; CELLS; AUTOANTIBODIES; MEROZOITE; VESICLES AB Erythrocytes infected with malaria parasites often contain membranous vesicles that are presumed to facilitate macromolecule traffic between the parasite and erythrocyte membranes. One such vesicle network, called Maurer's clefts, is expressed in Plasmodium falciparum-infected erythrocytes and contains a 50-kD polypeptide. Using a monoclonal antibody reactive with this polypeptide, we show that hepatic stages of P. falciparum express an epitope common to this blood-stage antigen. In addition, this epitope is cross-reactive with antigens expressed by primate leukocytes and platelets. Such epitopes may induce autoantibodies commonly seen in patients with malaria. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT IMMUNOL, WASHINGTON, DC 20307 USA. NIH, PARASIT DIS LAB, MALARIA SECT, BETHESDA, MD 20892 USA. GEORGE WASHINGTON UNIV, DEPT MICROBIOL & IMMUNOL, WASHINGTON, DC USA. USN, MED RES INST, BETHESDA, MD USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. CASE WESTERN RESERVE UNIV, INST PATHOL, CLEVELAND, OH 44106 USA. AFFYMAX RES INST, PALO ALTO, CA USA. FU NIAID NIH HHS [AI-10645] NR 31 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1996 VL 54 IS 6 BP 655 EP 659 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA UX379 UT WOS:A1996UX37900020 PM 8686788 ER PT J AU Thwaites, BK Nigus, DB Bouska, GW Mongan, PD Ayala, EF Merrill, GA AF Thwaites, BK Nigus, DB Bouska, GW Mongan, PD Ayala, EF Merrill, GA TI Intravenous ketorolac tromethamine worsens platelet function during knee arthroscopy under spinal anesthesia SO ANESTHESIA AND ANALGESIA LA English DT Article ID TROMETAMOL; VOLUNTEERS; HEMOSTASIS; ANALGESIA; SURGERY AB Ketorolac prolongs bleeding time and inhibits platelet aggregation and platelet thromboxane production in healthy, awake volunteers. However, platelet function was recently shown not to worsen after ketorolac was given during general anesthesia. The purpose of this study was to investigate platelet function changes during a standardized spinal anesthetic and surgery, as well as after a single intraoperative dose of intravenous (IV) ketorolac. The study comprised 30 ASA physical status I patients undergoing spinal anesthesia for knee arthroscopy. Subjects were randomized to receive either ketorolac 60 mg TV 15 min after skin incision or placebo IV. Platelet function testing consisted of an Ivy bleeding time, platelet aggregometry with adenosine diphosphate (ADP) and collagen, thromboelastography (TEG), and serum thromboxane B-2 (TxB(2)) assays. Platelet function testing was performed: 1) 15 min prior to the performance of spinal anesthesia; 2) 10 min after surgical skin incision; and 3) 45 min after administration of study drug. The placebo group demonstrated no changes in any platelet function variable during spinal anesthesia and surgery relative to preoperative values. The ketorolac group, however, demonstrated a significant increase in bleeding time from postincision to poststudy drug data points (213 +/- 60 s to 275 +/- 85 s, mean +/- SD P < 0.01). Further, platelet aggregometry to collagen was diminished in the ketorolac group from preoperative to poststudy drug data points (90.8% +/- 7.6% to 60.5% +/- 32.5%; P < 0.01). Platelet aggregometry with ADP, however, was unchanged in the ketorolac group. Platelet TxB(2), production decreased dramatically in the ketorolac group from preoperative to poststudy drug data points (157.2 +/- 129.4 to 0.3 +/- 0.3 ng/mL; P < 0.01). Platelet function does not appear to be accentuated during spinal anesthesia as it is during general anesthesia. Unlike during general anesthesia, platelet function during spinal anesthesia is impaired, with respect to bleeding time and platelet aggregometry to collagen, by a single intraoperative dose of IV ketorolac. C1 BROOKE ARMY MED CTR, DEPT CLIN INVEST, FT SAM HOUSTON, TX 78234 USA. RP Thwaites, BK (reprint author), BROOKE ARMY MED CTR, ANESTHESIA & OPERAT SERV, DEPT SURG, FT SAM HOUSTON, TX 78234 USA. NR 24 TC 19 Z9 19 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 EI 1526-7598 J9 ANESTH ANALG JI Anesth. Analg. PD JUN PY 1996 VL 82 IS 6 BP 1176 EP 1181 DI 10.1097/00000539-199606000-00013 PG 6 WC Anesthesiology SC Anesthesiology GA UM655 UT WOS:A1996UM65500013 PM 8638787 ER PT J AU Engler, RJM Weiss, RB AF Engler, RJM Weiss, RB TI Immediate hypersensitivity to human recombinant granulocyte-macrophage colony-stimulating factor associated with a positive prick skin test reaction SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID GM-CSF; CHEMOTHERAPY; YEAST AB Background: Recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF), also known as sargramostim, is used to accelerate myeloid recovery following bone marrow transplantation or cytotoxic chemotherapy. ''Anaphylactic'' reactions to sargramostim have been reported on a limited basis and are poorly characterized. Objective: It is the purpose of this report to describe an adverse reaction to sargramostim treatment involving palmar itching, urticaria, angioedema, and throat tightness and to demonstrate the utility of prick skin testing to determine type I sensitization. Methods: Prick skin testing with 100 and 250 mu g/mL sargramostim and 300 mu g/mL rhu G-CSF (filgrastim) was performed in the patient and four control subjects. Results: The patient experienced an immediate wheal and flare reaction with both concentrations of sargramostim while the control subjects demonstrated no reaction. There was also no reaction with filgrastim (rhu G-CSF) in either group and the patient subsequently tolerated filgrastim therapy. Conclusion: Prick skin testing with rhu GM-CSF and rhu G-CSF may be useful to demonstrate type I sensitization. Additional studies are needed to determine the incidence and prevalence of skin test reactions in larger numbers of patients with cytokine therapy exposure. C1 WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,DEPT MED,WASHINGTON,DC 20307. RP Engler, RJM (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,CLIN & LAB IMMUNOL TRAINING PROGRAM,WASHINGTON,DC 20307, USA. FU NCI NIH HHS [CA26806] NR 20 TC 8 Z9 9 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD JUN PY 1996 VL 76 IS 6 BP 531 EP 534 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA UR838 UT WOS:A1996UR83800008 PM 8673688 ER PT J AU Williford, SL King, T AF Williford, SL King, T TI Interferon alfa for macular degeneration SO ANNALS OF PHARMACOTHERAPY LA English DT Editorial Material ID SUBFOVEAL CHOROIDAL NEOVASCULARIZATION; ALPHA-2A C1 CAMPBELL UNIV,SCH PHARM,DEPT PHARM PRACTICE,BUIES CREEK,NC 27506. RP Williford, SL (reprint author), WOMACK ARMY MED CTR,FT BRAGG,NC 28307, USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD JUN PY 1996 VL 30 IS 6 BP 678 EP 679 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UQ728 UT WOS:A1996UQ72800018 PM 8792957 ER PT J AU Weiss, GR Shaffer, DW DeMoor, C Rinaldi, DA Rodriguez, GI Eckardt, JR Stephens, C VonHoff, DD AF Weiss, GR Shaffer, DW DeMoor, C Rinaldi, DA Rodriguez, GI Eckardt, JR Stephens, C VonHoff, DD TI A randomized phase I study of oral etoposide with or without granulocyte-macrophage colony-stimulating factor for the treatment of patients with advanced cancer SO ANTI-CANCER DRUGS LA English DT Article DE etoposide; granulocyte-macrophage colony stimulating factor (sargramostim); phase I trial ID CELL LUNG-CANCER; TRIAL; CHEMOTHERAPY; NEUTROPENIA; CARCINOMA; TUMORS AB The purpose of this study was to evaluate the feasibility of chronic oral administration of etoposide with granulocyte-macrophage colony-stimulating factor (GM-CSF) [sargramostim (Immunex)] coadministration or premedication; to estimate and compare the frequency of toxicities accompanying etoposide administration alone, etoposide/GM-CSF coadministration and etoposide with GM CSF premedication. Thirty-nine advanced treatment-refractory enrolled to this study. Eligible patients were randomized to one of three treatment arms: daily oral etoposide alone for 21 days (arm A); daily oral etoposide for 21 days with GM-CSF, 250 mu g/m(2), s.c. twice daily for the first 10 days of etoposide administration (arm B); or daily oral etoposide for 21 days with GM-CSF twice daily for the sixth through second days preceding etoposide administration (arm C), Courses of treatment were repeated every 28 days. Etoposide dosages for each arm were 25, 50, 75 and 100 mg/m(2)/day. At least three patients were treated at each dosage level until dose-limiting toxicity was observed, Patients had twice weekly blood counts and weekly clinical examinations to assess toxicity. Patients with measurable or evaluable evidence of cancer were assessed for antitumor response after every other course of therapy, Nadir neutrophil counts at each dosage level were compared between treatment arms by non-parametric Wilcoxen rank sum tests, GM-CSF coadministration (arm B) or premedication (arm C) with daily chronic oral etoposide was feasible and did not lead to excessive hematological toxicity, Pairwise comparisons of neutrophil nadirs for the first course of therapy for each treatment arm did not demonstrate any significant differences and, at most, a slight trend favoring improved neutrophil nadirs was shown for arm C compared to arm A (p = 0.07), Dose intensity as measured by mean days of etoposide administered per patient for each arm suggested only slight improvement in etoposide tolerance for treatment arms B and C, The conclusion, GM-CSF can be safely administered to patients receiving chronic daily oral etoposide. It appears that GM-CSF provides no clinically useful improvement in granulocyte tolerance of therapy. C1 CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. EISENHOWER ARMY MED CTR,FT GORDON,GA. WESTPACES FERRY MED CLIN,ATLANTA,GA. RP Weiss, GR (reprint author), UNIV TEXAS,HLTH SCI CTR,DIV MED ONCOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 20 TC 2 Z9 2 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD JUN PY 1996 VL 7 IS 4 BP 402 EP 409 DI 10.1097/00001813-199606000-00005 PG 8 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA UX719 UT WOS:A1996UX71900005 PM 8826608 ER PT J AU Knapik, J Harman, E Reynolds, K AF Knapik, J Harman, E Reynolds, K TI Load carriage using packs: A review of physiological, biomechanical and medical aspects SO APPLIED ERGONOMICS LA English DT Review DE backpack; double pack; load bearing; energy expenditure; physical conditioning; gait; electromyography; injuries ID ENERGY-EXPENDITURE; TERRAIN COEFFICIENTS; STRESS-FRACTURES; DOWNHILL WALKING; METABOLIC COST; HARD-WORK; EXERCISE; MEN; BACKPACK; WOMEN AB This paper reviews the biomedical aspects of transporting loads in packs and offers suggestions for improving load-carriage capability. Locating the load mass as close as possible to the body center of gravity appears to result in the lowest energy cost when carrying a pack. Thus, the double pack (half the load on the front of the body and half the load on the back) has a lower energy cost than the backpack. However, backpacks provide greater versatility in most situations. The energy cost of walking with backpack loads increases progressively with increases in load mass, body mass, walking speed or grade; type of terrain also influences energy cost. Predictive equations have been developed for estimating the energy cost of carrying loads during locomotion but these may not be accurate for prolonged (>2 h) or downhill carriage. Training with loads can result in greater energy efficiency since walking with backpack loads over several weeks decreases energy cost. Load-carriage speed can be increased with physical training that involves regular running and resistance training. Erector spinae electrical activity (EMG) is lower during load carriage than in unloaded walking until loads exceed 30-40 kg, at which point erector spinae EMG activity is higher than during unloaded walking. EMGs of the quadriceps and gastrocnemius, but not the tibialis anterior or hamstrings, increase with load. Framed packs with hip belts reduce the electrical activity of the trapezius muscles, presumably by shifting forces from the shoulders to the hips. Increases in the backpack load mass result in increases in forces exerted on the grounds, amount of knee flexion and the forward inclination of the trunk. Compared to backpacks, double packs produce fewer deviations from normal walking. Common injuries associated with prolonged load carriage include foot blisters, stress fractures, back strains, metatarsalgia (foot pain), rucksack palsy (shoulder traction injury) and knee pain. Closed-cell neoprene insoles and use of an acrylic or nylon sock, combined with a wool sock, reduce blister incidence. A framed pack with a hip belt reduces the incidence of rucksack palsy. Backpack load carriage can be facilitated by lightening loads, optimizing equipment, improving load distribution and by preventive action aimed at reducing the incidence of injury. Published by Elsevier Science Ltd. C1 USA,ENVIRONM MED RES INST,OCCUPAT MED DIV,NATICK,MA 01760. USA,ENVIRONM MED RES INST,OCCUPAT PHYSIOL DIV,NATICK,MA 01760. RP Knapik, J (reprint author), USA,RES LAB,SOLDIER PERFORMANCE DIV,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 117 TC 177 Z9 180 U1 7 U2 37 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0003-6870 J9 APPL ERGON JI Appl. Ergon. PD JUN PY 1996 VL 27 IS 3 BP 207 EP 216 DI 10.1016/0003-6870(96)00013-0 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA UP471 UT WOS:A1996UP47100009 PM 15677062 ER PT J AU Traub, WA Winkel, RJ Goldman, A AF Traub, WA Winkel, RJ Goldman, A TI Fourier-transform spectroscopy: New methods and applications: Introduction by the feature editors SO APPLIED OPTICS LA English DT Article AB We are pleased to introduce this special issue of papers on Fourier-transform spectroscopy, which grew out of a recent topical meeting sponsored by the Optical Society of America. The topical meeting welcomed all researchers who practice the art of Fourier-transform spectroscopy in the laboratory, in the atmosphere, and in space. The power and the wide applicability of Fourier-transform spectroscopy unite these fields with a common mathematical and instrumental bond. The meeting probed each of these areas in depth, bringing out new ideas for instrumentation analysis, and applications. There was a strong sentiment at the meeting that the quality of papers and posters was exceptionally high and that it would be important for future progress in the field to have the results of this meeting captured in print. This special issue is the fruit of that effort. (C) 1996 Optical Society of America C1 US MIL ACAD,DEPT PHYS,W POINT,NY 10996. UNIV DENVER,DEPT PHYS,DENVER,CO 80208. RP Traub, WA (reprint author), SMITHSONIAN ASTROPHY OBSERV,CTR ASTROPHYS,60 GARDEN ST,CAMBRIDGE,ENGLAND. NR 3 TC 1 Z9 1 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 1 PY 1996 VL 35 IS 16 BP 2732 EP 2733 DI 10.1364/AO.35.002732 PG 2 WC Optics SC Optics GA UQ482 UT WOS:A1996UQ48200002 PM 21085420 ER PT J AU Winkel, RJ Davis, SP Abrams, MC AF Winkel, RJ Davis, SP Abrams, MC TI Fourier transform spectroscopy of LaS in the infrared SO APPLIED OPTICS LA English DT Article DE Fourier transform spectroscopy; lanthanum sulfide; infrared spectrum AB We recorded the emission spectrum of diatomic lanthanum sulfide on the Los Alamos Fourier transform spectrometer. In the region 7500-16,000 cm(-1), we identified over 120 bands and assigned them to the A (2) Pi(r)-X (2) Sigma(+) and B (2) Sigma(+)-X (2) Sigma(+) transitions. Each of these bands is four headed, (C) 1996 Optical Society of America C1 UNIV CALIF BERKELEY,DEPT PHYS,BERKELEY,CA 94720. NASA,LANGLEY RES CTR,SAIC,HAMPTON,VA 23681. RP Winkel, RJ (reprint author), US MIL ACAD,DEPT PHYS,W POINT,NY 10996, USA. NR 6 TC 7 Z9 8 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 1 PY 1996 VL 35 IS 16 BP 2874 EP 2878 PG 5 WC Optics SC Optics GA UQ482 UT WOS:A1996UQ48200017 PM 21085435 ER PT J AU Rosen, LN Durand, DB Bliese, PD Halverson, RR Rothberg, JM Harrison, NL AF Rosen, LN Durand, DB Bliese, PD Halverson, RR Rothberg, JM Harrison, NL TI Cohesion and readiness in gender-integrated combat service support units: The impact of acceptance of women and gender ratio SO ARMED FORCES & SOCIETY LA English DT Article AB Cohesion, combat readiness and acceptance of women were examined among male and female junior enlisted soldiers and male noncommissioned officers (NCOs) in 19 combat service support companies. The proportion of junior enlisted females in each company was negatively correlated with mean cohesion and readiness scores for junior enlisted males. The proportion of NCO females was significantly correlated with the proportion of soldiers who said they did not expect to deploy with their units, which in turn was negatively correlated with cohesion for male NCOs. For junior enlisted males, results indicated that cohesion and combat readiness increased with increased acceptance of women, but decreased as the proportion of females in the unit increased. Furthermore, acceptance of women decreased as the proportion of females in the unit increased. The results are interpreted in the light of two competing hypotheses regarding minority proportional representation-the tokenism hypothesis and the minority-proportion discrimination hypothesis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. RP Rosen, LN (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,UWIA,MCMR,WASHINGTON,DC 20307, USA. NR 39 TC 27 Z9 27 U1 1 U2 2 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1996 VL 22 IS 4 BP 537 EP & DI 10.1177/0095327X9602200403 PG 18 WC Political Science; Sociology SC Government & Law; Sociology GA VB686 UT WOS:A1996VB68600002 ER PT J AU Andrade, D AF Andrade, D TI Codename Mule: Fighting the secret war in Laos for the CIA - Parker,JE SO ARMED FORCES & SOCIETY LA English DT Book Review RP Andrade, D (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1996 VL 22 IS 4 BP 643 EP 648 DI 10.1177/0095327X9602200408 PG 6 WC Political Science; Sociology SC Government & Law; Sociology GA VB686 UT WOS:A1996VB68600010 ER PT J AU Andrade, D AF Andrade, D TI Back fire: The CIA's secret war in Laos and its link to the war in Vietnam - Warner,R SO ARMED FORCES & SOCIETY LA English DT Book Review RP Andrade, D (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1996 VL 22 IS 4 BP 643 EP 648 DI 10.1177/0095327X9602200408 PG 6 WC Political Science; Sociology SC Government & Law; Sociology GA VB686 UT WOS:A1996VB68600009 ER PT J AU Andrade, D AF Andrade, D TI Shadow war: The CIA's secret war in Laos - Conboy,K SO ARMED FORCES & SOCIETY LA English DT Book Review RP Andrade, D (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1996 VL 22 IS 4 BP 643 EP 648 DI 10.1177/0095327X9602200408 PG 6 WC Political Science; Sociology SC Government & Law; Sociology GA VB686 UT WOS:A1996VB68600008 ER PT J AU Andrade, D AF Andrade, D TI At war in the shadow of Vietnam: US military aid to the royal Lao government, 1955-1975 - Castle,TN SO ARMED FORCES & SOCIETY LA English DT Book Review RP Andrade, D (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1996 VL 22 IS 4 BP 643 EP 648 DI 10.1177/0095327X9602200408 PG 6 WC Political Science; Sociology SC Government & Law; Sociology GA VB686 UT WOS:A1996VB68600007 ER PT J AU Gilliland, W Geockeritz, B Tesar, J Dennis, G AF Gilliland, W Geockeritz, B Tesar, J Dennis, G TI Musculoskeletal (MS) complaints in operation desert storm (ODS) veterans SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1996 VL 39 IS 6 SU S BP R21 EP R21 PG 1 WC Rheumatology SC Rheumatology GA UQ616 UT WOS:A1996UQ61600074 ER PT J AU Jackson, LW Dennis, GJ AF Jackson, LW Dennis, GJ TI A demographic, immunologic and diagnostic profile in African American women with silicone breast implants. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1996 VL 39 IS 6 SU S BP R21 EP R21 PG 1 WC Rheumatology SC Rheumatology GA UQ616 UT WOS:A1996UQ61600077 ER PT J AU Schwartz, PS Finbloom, DS AF Schwartz, PS Finbloom, DS TI Effects of dexamethasone (Dex) on interferon gamma induced activation of the stat transcription factor pathway and map kinase (MAPK) activity in rat basophilic leukemia (RBL) cells. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. US FDA,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1996 VL 39 IS 6 SU S BP R25 EP R25 PG 1 WC Rheumatology SC Rheumatology GA UQ616 UT WOS:A1996UQ61600098 ER PT J AU Sullivan, NM Dennis, GJ Aronson, N AF Sullivan, NM Dennis, GJ Aronson, N TI The ten year clinical course of a rheumatoid arthritis patient with human immunodeficiency virus infection. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1996 VL 39 IS 6 SU S BP R24 EP R24 PG 1 WC Rheumatology SC Rheumatology GA UQ616 UT WOS:A1996UQ61600092 ER PT J AU Comperatore, CA Lieberman, HR Kirby, AW Adams, B Crowley, JS AF Comperatore, CA Lieberman, HR Kirby, AW Adams, B Crowley, JS TI Melatonin efficacy in aviation missions requiring rapid deployment and night operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID JET-LAG; SLEEP; LIGHT AB Background: The rapid deployment of Army aviation personnel across time zones, combined with missions beginning immediately upon arrival, results in desynchronization oi physiological and cognitive performance rhythms. Implementation of effective countermeasures enhances safety, health, well-being, anti mission completion. The naturally occurring hormone melatonin has been suggested as al? effective countermeasure for jet lag and shift lag because of its influence on the human circadian timing system and its hypnotic properties. Method: The efficacy of melatonin (10 mg) in maintaining stable sleep/wake cycles of Army aircrews was tested during a training mission involving rapid deployment to the,Middle East and night operations. Cognitive performance was tested before and after travel; activity rhythms were recorded continuously for 13 d. Results: Melatonin treatment advanced both bedtimes and rise times (2-3 h) and maintained sleep durations between 7-8 h. Placebo treatment was mostly associated with longer advances in rise times than bedtimes resulting in shorter sleep durations (5-7 h). Upon awakening, the melatonin group exhibited significantly fewer errors (mean: 7.45) than the placebo group (mean: 14.50) in a dual-task vigilance test. Conclusion: Melatonin can be a useful treatment for the prevention of sleep disruptions and cognitive degradation, even in uncontrolled sleeping environments characteristic of military deployments. C1 USA,INST ENVIRONM MED,NATICK,MA 01760. RP Comperatore, CA (reprint author), USA,AIRCREW HLTH & PERFORMANCE DIV,AEROMED FACTORS BRANCH,AEROMED RES LAB,MCMR,UAS,FT RUCKER,AL 36362, USA. NR 17 TC 40 Z9 41 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 1996 VL 67 IS 6 BP 520 EP 524 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA UP130 UT WOS:A1996UP13000003 PM 8827132 ER PT J AU Gentile, BJ SzlykModrow, PC Durkot, MJ Krestel, BA Sils, IV Tartarini, KA Alkhyyat, AM AF Gentile, BJ SzlykModrow, PC Durkot, MJ Krestel, BA Sils, IV Tartarini, KA Alkhyyat, AM TI A miniswine model of acute exertional heat exhaustion SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID PROLONGED EXERCISE; TOLERANCE; BLOOD; PERFORMANCE; TEMPERATURE; HEATSTROKE AB Method: We examined the thermoregulatory and hemodynamic responses of 12 miniswine (31 +/- 3.9 kg) during 25-30 min of treadmill exercise (5.4 km . h(-1), 5% grade) under cool (10 degrees C), moderate (20 degrees C) and warm (30 degrees C) ambient temperature (Ta) conditions. Results: Within 15-20 min of exercise at Ta = 30 degrees C, the miniswine demonstrated significant hyperventilation, hypersalivation, and unsteady gait. Exercise-heat endurance time (T) at Ta = 30 degrees C decreased by 35% and 40% in comparison to T at Ta = 20 degrees C and 10 degrees C, respectively. This resulted from a significant rise in heat strain (S)-defined as the rate of change in rectal temperature. Averaged throughout exercise, S increased from 0.04 +/- 0.01 degrees C . min(-1) and 0.05 +/- 0.02 degrees C . min(-1) at Ta = 10 degrees C and 20 degrees C, respectively, to 0.10 +/- 0.03 degrees C . min(-1) at Ta = 30 degrees C. Due to the comparatively large storage capacity of the porcine spleen relative to humans, splenectomized miniswine were used. This permitted calculation of percentage changes in plasma volume (%Delta PVc) from hematocrit (HCT) and hemoglobin (HGB) without the confounding effects oi splenic red cells released into the circulation during exercise. Independent of Ta, preexercise PVc decreased 3%-5% (p less than or equal to 0.05) within the first 10 min of exercise, but increased 5%-9% (p less than or equal to 0.05) by 10 min post-exercise. Conclusion: We conclude that the poor thermoregulatory ability of miniswine manifested in insignificant sweating and restricted evaporative cooling, may make them an appropriate model for acute exertional heat exhaustion in humans working in hot, humid conditions and/or wearing impermeable protective clothing. Further, evaluation of plasma volume changes from HCT and HGB in a miniswine model should consider the merit ai a splenectomized design. RP Gentile, BJ (reprint author), USA,ENVIRONM MED RES INST,ANIM RESOURCES BRANCH,NATICK,MA 01760, USA. NR 25 TC 3 Z9 3 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 1996 VL 67 IS 6 BP 560 EP 567 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA UP130 UT WOS:A1996UP13000009 PM 8827138 ER PT J AU James, LC Folen, RA AF James, LC Folen, RA TI EEG biofeedback as a treatment for chronic fatigue syndrome: A controlled case report SO BEHAVIORAL MEDICINE LA English DT Article; Proceedings Paper CT Hawaii-Psychological-Association Convention CY FEB 08, 1995 CL HONOLULU, HI SP Hawaii Psychol Assoc DE chronic fatigue syndrome; electroencephalograph (EEG) neurobiofeedback AB EEG neurofeedback has been identified as a potential diagnostic and treatment protocol with chronic fatigue syndrome (CFS) symptoms. In the present case study, the authors applied an EEG neurofeedback biofeedback paradigm as a treatment modality with a CFS patient. Baseline data were acquired using the Wechsler Adult Intelligence Scale-Revised and qualitative and subjective ratings of cognitive improvement. Test results and clinical findings revealed improvements in the patient's cognitive abilities, functional skill level, and quality of life. The patient showed significant differences in pre- and posttest levels on the Wechsler scale. RP James, LC (reprint author), TRIPLER ARMY MED CTR,DEPT PSYCHOL,CLIN HLTH PSYCHOL SERV,HONOLULU,HI 96859, USA. NR 17 TC 7 Z9 8 U1 1 U2 5 PU HELDREF PUBLICATIONS PI WASHINGTON PA 1319 EIGHTEENTH ST NW, WASHINGTON, DC 20036-1802 SN 0896-4289 J9 BEHAV MED JI Behav. Med. PD SUM PY 1996 VL 22 IS 2 BP 77 EP 81 PG 5 WC Behavioral Sciences; Psychiatry SC Behavioral Sciences; Psychiatry GA VJ527 UT WOS:A1996VJ52700004 PM 8879459 ER PT J AU Shorr, AF Wiesen, AR Byrd, JC Hospenthal, DR Glass, KL Diehl, LF AF Shorr, AF Wiesen, AR Byrd, JC Hospenthal, DR Glass, KL Diehl, LF TI The impact of the administration of packed red blood cells in the evaluation of the post-transfusion patient SO BRITISH JOURNAL OF HAEMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1048 J9 BRIT J HAEMATOL JI Br. J. Haematol. PD JUN PY 1996 VL 93 SU 2 BP 1225 EP 1225 PG 1 WC Hematology SC Hematology GA UP114 UT WOS:A1996UP11401224 ER PT J AU McPhee, MG Ackley, SF Guest, P Huber, BA Martinson, DG Morison, JH Muench, RD Padman, L Stanton, TP AF McPhee, MG Ackley, SF Guest, P Huber, BA Martinson, DG Morison, JH Muench, RD Padman, L Stanton, TP TI The Antarctic Zone Flux Experiment SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID WINTER MIXED LAYER; SEA-ICE; WEDDELL SEA; PACK ICE; OCEAN; WATER; MODEL; TEMPERATURE; THICKNESS; POLYNYA AB In winter the eastern Weddell Sea in the Atlantic sector of the Southern Ocean hosts some of the most dynamic air-ice-sea interactions found on earth. Sea ice in the region is kept relatively thin by heat flux from below, maintained by upper-ocean stirring associated with the passage of intense, fast-moving cyclones. Ocean stratification is so weak that the possibility of deep convection exists, and indeed, satellite imagery from the Weddell Sea in the 1970s shows a large expanse of open water (the Weddell Polynya) that persisted through several seasons and may have significantly altered global deep-water production. Understanding what environmental conditions could again trigger widespread oceanic overturn may thus be an important key in determining the role of high latitudes in deep-ocean ventilation and global atmospheric warming. During the Antarctic Zone Flux Experiment in July and August 1994, response of the upper ocean and its ice cover to a series of storms was measured at two drifting stations supported by the National Science Foundation research icebreaker Nathaniel B. Palmer. This article describes the experiment, in which fluxes of heat, mass, and momentum were measured in the upper ocean, sea ice, and lower-atmospheric boundary layer. Initial results illustrate the importance of oceanic heat flux at the ice undersurface for determining the character of the sea ice cover. They also show how the heat flux depends both on high levels of turbulent mixing during intermittent storm events and on large variability in the stratified upper ocean below the mixed layer. C1 MCPHEE RES CO,NACHES,WA. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. USN,POSTGRAD SCH,MONTEREY,CA. LAMONT DOHERTY EARTH OBSERV,PALISADES,NY 10964. WASHINGTON UNIV,POLAR SCI CTR,SEATTLE,WA. EARTH & SPACE RES,SEATTLE,WA. OREGON STATE UNIV,COLL OCEAN & ATMOSPHER SCI,CORVALLIS,OR 97331. NR 38 TC 60 Z9 61 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD JUN PY 1996 VL 77 IS 6 BP 1221 EP 1232 DI 10.1175/1520-0477(1996)077<1221:TAZFE>2.0.CO;2 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA VC043 UT WOS:A1996VC04300006 ER PT J AU Meier, HL AF Meier, HL TI The time-dependent effect of 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) on the lymphocyte viability and the kinetics of protection by poly(ADP-ribose) polymerase inhibitors SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE sulfur mustard; HD; poly(ADP-ribose) polymerase; alkylated DNA; in vitro assay; cytotoxicity assay AB 2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis[2-chloroethane]) is a potent vesicant which can cause severe lesions to skin, lung, and eyes. Due to the high number of debilitating exposures during the Iran-Iraq war to the alkylating agent, HD, there is an increased interest in its mechanism of action and in the development of therapeutic interventions to prevent HD-induced lesions. Recently we reported an in vitro assay using human mononuclear leukocytes for studying HD-induced pathology To study the time dependence of HD-induced mononuclear leukocyte cell death and to determine the parameters of any potential therapeutic intervention, an assay was developed and automated using a flow cytometer to measure propidium iodide exclusion by mononuclear cells. This assay demonstrated that HD-initiated cell death did not begin before 4 h post-exposure, but after 4 h proceeded in a concentration-dependent manner. In this assay, both niacinamide and 3-aminobenzamide, poly(ADP-ribose) polymerase inhibitors, were shown to be effective in blocking HD-induced cell death when added to the cultures during the first 4 h postexposure. They offered partial protection when added between 6 and 12 h and were of no benefit when added after 12 h post-exposure. RP Meier, HL (reprint author), USA,MED RES INST CHEM DEF,SG,RD,UV,DB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 17 Z9 21 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUN PY 1996 VL 12 IS 3 BP 147 EP 153 DI 10.1007/BF00148168 PG 7 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA UX424 UT WOS:A1996UX42400003 PM 8817060 ER PT J AU Cardello, AV AF Cardello, AV TI The role of the human senses in food behavior .2. Texture SO CEREAL FOODS WORLD LA English DT Article ID QUALITY; TASTE RP Cardello, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 12 TC 0 Z9 0 U1 1 U2 4 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD JUN PY 1996 VL 41 IS 6 BP 469 EP 470 PG 2 WC Food Science & Technology SC Food Science & Technology GA UU432 UT WOS:A1996UU43200007 ER PT J AU Argyros, GJ Roach, JM Hurwitz, KM Eliasson, H Phillips, YY AF Argyros, GJ Roach, JM Hurwitz, KM Eliasson, H Phillips, YY TI Eucapnic voluntary hyperventilation as a bronchoprovocation technique - A development of a standardized dosing schedule in asthmatics SO CHEST LA English DT Article DE asthma; bronchoprovocation; exercise; hyperventilation ID EXERCISE-INDUCED ASTHMA; ISOCAPNIC HYPERVENTILATION; BRONCHIAL CHALLENGE; WATER-LOSS; HEAT-FLUX; STIMULUS; HYPERREACTIVITY; REPRODUCIBILITY AB A variety of dosing schedules have been reported for the hyperventilation method of bronchoprovocation testing. To evaluate the effect of challenge technique on the bronchoconstrictive response, we had 16 subjects perform eucapnic voluntary hyperventilation (EVH) with dry, room temperature gas using four different dosing schedules. The hyperventilation challenge dosages included the following: (1) a target minute ventilation (V over dot E) of 20 x FEV(1) for 6 min; (2) a target V over dot E of 15 x FEV(1) for 12 min; (3) an interrupted challenge with a target V over dot E of 30 x FEV(1) for 2 min repeated 3 times; and (4) a target V over dot E of 30 x FEV(1) for 6 min. Challenges 2, 3, and 4 gave identical absolute ventilatory challenges (identical factor FEV(1) x minutes) but at different V over dot E dosages or time, Challenges 1 and 4 were of identical length, but different target V over dot E. The mean postchallenge fall in FEV(1) was 16.6+/-10.9%, 11.0+/-8.1%, 19.6+/-9.9%, and 26.7+/-11.3% for challenges 1, 2, 3, and 4, respectively. The response to an identical EVH challenge (FEV(1) x 30 for 6 min) was reproducible when performed on separate days. We conclude that the challenge technique used for hyperventilation testing will have a significant impact on the bronchoconstrictive response and must be taken into account when interpreting study results. Tests may be quantitatively comparable over a narrow range of challenge time and V over dot E. We recommend that a 6-min uninterrupted EVH challenge using room temperature gas at a target V over dot E of 30xFEV(1) be adopted as the ''standard'' challenge. C1 WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. USA,INST ENVIRONM MED,NATICK,MA 01760. NR 30 TC 57 Z9 57 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD JUN PY 1996 VL 109 IS 6 BP 1520 EP 1524 DI 10.1378/chest.109.6.1520 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UQ396 UT WOS:A1996UQ39600023 PM 8769504 ER PT J AU Rosa, MP Johnson, EA Barcia, PJ AF Rosa, MP Johnson, EA Barcia, PJ TI The impossible airway - A plan SO CHEST LA English DT Article DE airway; bypass; portable cardiopulmonary support unit ID PORTABLE CARDIOPULMONARY BYPASS; EXPERIENCE AB A patient presented with near complete airway obstruction due to a massive tumor. Nonsurgical methods failed to secure the airway, and surgical approaches were considered unlikely to succeed in a timely fashion. Cardiopulmonary bypass via femoral-femoral cannulation with the use of local anesthesia and a portable unit, followed by IV anesthesia, allowed the surgeons to perform a controlled tracheotomy. C1 TRIPLER ARMY MED CTR,DEPT SURG,GEN SURG SERV,HONOLULU,HI 96859. NR 5 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD JUN PY 1996 VL 109 IS 6 BP 1649 EP 1650 DI 10.1378/chest.109.6.1649 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UQ396 UT WOS:A1996UQ39600045 ER PT J AU AIMONE, AC AF AIMONE, AC TI COMPENDIUM OF THE CONFEDERATE ARMIES, VOL 1, FLORIDA AND ARKANSAS, VOL 2, TEXAS, VOL 3, LOUISIANA, VOL 4, KENTUCKY, MARYLAND, MISSOURI, THE CONFEDERATE UNITS AND THE INDIAN UNITS, VOL 5, MISSISSIPPI, VOL 6, SOUTH-CAROLINA AND GEORGIA - SIFAKIS,S SO CIVIL WAR HISTORY LA English DT Book Review RP AIMONE, AC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA KENT, OH 44242 SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 1996 VL 42 IS 2 BP 167 EP 169 PG 3 WC History SC History GA UX021 UT WOS:A1996UX02100012 ER PT J AU Plemmons, RM McAllister, CK Liening, DA Garces, MC AF Plemmons, RM McAllister, CK Liening, DA Garces, MC TI Otitis media and mastoiditis due to Mycobacterium fortuitum: Case report, review of four cases, and a cautionary note SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID INFECTION; CHELONEI AB Mycobacterium fortuitum is a rarely reported cause of otitis media and mastoiditis. We report such a case recently seen at our institution and review the four previously published cases of this disease entity. Amikacin is recommended in the current medical literature as empirical treatment of disease due to M. fortuitum, but the isolate from our patient showed high-level resistance to amikacin, which is rare in clinical isolates of this species; this resistance was probably related to prior treatment with topical aminoglycosides. Our patient's infection responded to a 12-month course of therapy with clarithromycin and trimethoprim-sulfamethoxazole. C1 BROOKE ARMY MED CTR, OTOLARYNGOL SERV, FT SAM HOUSTON, TX 78234 USA. BROOKE ARMY MED CTR, AREA LAB SERV, FT SAM HOUSTON, TX 78234 USA. BROOKE ARMY MED CTR, DEPT MED, INFECT DIS SERV, USA MED CORPS, FT SAM HOUSTON, TX 78234 USA. NR 10 TC 13 Z9 13 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN PY 1996 VL 22 IS 6 BP 1105 EP 1106 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UQ794 UT WOS:A1996UQ79400038 PM 8783722 ER PT J AU Taylor, DN Rizzo, J Meza, R Perez, J Watts, D AF Taylor, DN Rizzo, J Meza, R Perez, J Watts, D TI Cholera among Americans living in Peru SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID TRAVELERS C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. US EMBASSY,HLTH UNIV,LIMA,PERU. NAVAL MED RES INST DETACHMENT,LIMA,PERU. NR 10 TC 14 Z9 14 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN PY 1996 VL 22 IS 6 BP 1108 EP 1109 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UQ794 UT WOS:A1996UQ79400040 PM 8783724 ER PT J AU Kester, KE Byrd, JC Rearden, TP Zacher, LL Cragun, WH Hargis, JB AF Kester, KE Byrd, JC Rearden, TP Zacher, LL Cragun, WH Hargis, JB TI Granulomatous Pneumocystis carinii pneumonia in patients with low-grade lymphoid malignancies: A diagnostic dilemma SO CLINICAL INFECTIOUS DISEASES LA English DT Article C1 WALTER REED ARMY MED CTR,SERV HEMATOL ONCOL,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,SERV HEMATOL ONCOL,TACOMA,WA 98431. MADIGAN ARMY MED CTR,SERV PULM CRIT CARE,TACOMA,WA 98431. RP Kester, KE (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,INFECT DIS SERV,WASHINGTON,DC 20307, USA. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 8 TC 12 Z9 12 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN PY 1996 VL 22 IS 6 BP 1111 EP 1112 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UQ794 UT WOS:A1996UQ79400042 PM 8783726 ER PT J AU Durkot, MJ Hoyt, RW Darrigrand, A Hubbard, LJ Kamimori, GH Cymerman, A AF Durkot, MJ Hoyt, RW Darrigrand, A Hubbard, LJ Kamimori, GH Cymerman, A TI Chronic hypobaric hypoxia decreases intracellular and total body water in microswine SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY LA English DT Article DE microswine; altitude; extracellular fluid; plasma volume; edema ID HIGH-ALTITUDE EXPOSURE; FLUID COMPARTMENTS; SHIFTS AB The effects of hypobaric hypoxia on body fluid distribution were studied in five unanesthetized immature microswine (body weight 17.1 +/- 1.5 kg, mean +/- SEM) at sea level and after 23 days of simulated altitude exposure (427 Ton, 4600 m, 24 degrees C, 50% RH). Total body water (TBW), extracellular fluid volume (ECF), and plasma volume (PV) were determined with D2O, NaBr, and indocyanine green, respectively. Intracellular fluid volume (ICF = TBW - ECF) and interstitial fluid volume (ISF = ECF - PV) were calculated. Hypoxia resulted in characteristic decreases (P < 0.05) in arterial PO2 and PCO2, and an increase in hemoglobin concentration. Chronic exposure to hypobaric hypoxia elicited significant (P < 0.05) decrements in body weight gain (-14%), TBW (-11%, 12.5 vs 11.3 L), ICF volume (-13%, 8.9 vs 7.8 L) and PV (-28%, 0.82 vs 0.57 L). Although the ECF was unaffected (3.66 vs 3.57 L), the ISF was significantly increased (+6%, 2.83 vs 3.22 L) (P < 0.05). Decreased TBW accounted for 51% of the expected reduction in body mass. These results suggest that the suppression in body weight gain is partially accounted for by decreases in TBW, ICF and PV. In addition the apparent elevation of ISF occurring concurrently with decreases in ICF and PV may be related to the development of edema, which can accompany exposure to high altitude. C1 USA,ENVIRONM MED RES INST,ALTITUDE DIV,NATICK,MA 01760. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. RP Durkot, MJ (reprint author), USA,ENVIRONM MED RES INST,COMPARAT PHYSIOL LAB,NATICK,MA 01760, USA. NR 28 TC 1 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0300-9629 J9 COMP BIOCHEM PHYS A JI Comp. Biochem. Physiol. A-Physiol. PD JUN PY 1996 VL 114 IS 2 BP 117 EP 121 DI 10.1016/0300-9629(95)02103-5 PG 5 WC Biochemistry & Molecular Biology; Physiology; Zoology SC Biochemistry & Molecular Biology; Physiology; Zoology GA UP193 UT WOS:A1996UP19300004 ER PT J AU Byczkowski, JZ Channel, SR Pravecek, TL Miller, CR AF Byczkowski, JZ Channel, SR Pravecek, TL Miller, CR TI Mathematical model for chemically induced lipid peroxidation in precision-cut liver slices: Computer simulation and experimental calibration SO COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE LA English DT Article DE biologically based pharmacodynamic model; liver in vitro; lipid peroxidation, tert-butyl hydroperoxide; toxicology ID TISSUE-SLICES; OXYGEN; INJURY; MALONDIALDEHYDE; MICROSOMES; DAMAGE AB A biologically based pharmacodynamic (BBPD) model was developed in order to describe and simulate chemically induced lipid peroxidation in precision cut mouse liver slices. The model was written in Advanced Continuous Simulation Language (ACSL) and simulations were performed using SIMUSOLV software on a VAX/VMS mainframe computer, The BBPD model simulated formation of lipid hydroperoxides and thiobarbituric acid reactive substances (TEARS) over time as a function of the amounts of cytochrome P450 (CYP)-activated chemical inducer and active antioxidants, The rate of peroxidation was controlled by lipid peroxidizability, destruction of CYP, autooxidation, and activity of glutathione peroxidase, The BBPD model was initially parameterized with the literature data for TEARS formation during lipid peroxidation, reported for rat liver slices induced with bromotrichloromethane and tert-butyl hydroperoxide (TBOOH). Then, the biochemical parameters were adjusted to reflect the physiology of the mouse liver, and the BBPD model was used to simulate TEARS formation during lipid peroxidation in precision cut mouse liver slices induced with TBOOH. The BBPD model predictions were in agreement with the experimental data. C1 ARMSTRONG LAB,TOX HAZARDS DIV,WRIGHT PATTERSON AFB,OH 45433. USA,MED RES DETACHMENT,WRIGHT PATTERSON AFB,OH 45433. RP Byczkowski, JZ (reprint author), MANTECH ENVIRONM TECHNOL INC,POB 31009,DAYTON,OH 45437, USA. NR 32 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0169-2607 J9 COMPUT METH PROG BIO JI Comput. Meth. Programs Biomed. PD JUN PY 1996 VL 50 IS 1 BP 73 EP 84 DI 10.1016/0169-2607(96)01735-X PG 12 WC Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods; Engineering, Biomedical; Medical Informatics SC Computer Science; Engineering; Medical Informatics GA UY398 UT WOS:A1996UY39800008 PM 8835842 ER PT J AU Nanni, A Bakis, CE ONeil, EF Dixon, TO AF Nanni, A Bakis, CE ONeil, EF Dixon, TO TI Short-term sustained loading of FRP tendon-anchor systems SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE FRP tendon-anchors; short-term loading; aramid AB The scope of the paper is to provide a short-term evaluation of some commercially available FRP tendon-anchor systems for application in prestressed concrete structures. Ten FRP tendon-anchor systems were stressed and subjected to sustained load for a period of three days to determine ease of installation, mechanical performance and anchor seating losses. The FRP tendons used aramid, carbon, and glass fibres embedded in epoxy or vinyl ester resin (except for one case). Anchors were of the wedge (or spike) and potted type. A minimum of two tests were conducted for each system at a load level equal to 65% of the manufacturer's specified ultimate tendon strength. Collected data included load, strain, and displacement readings during both initial stressing and three-day sustained load. In most cases, anchorage devices permitted the stressing of the FRP tendons at the desired load level. Among wedge-type anchors, plastic and aluminium wedges had questionable performance, whereas steel wedges (in direct contact with the tendon or using a metal sleeve between tendon and wedge) showed good performance. Regardless of wedge material (plastic, aluminium, or steel), grit application to the wedge internal surface was highly beneficial. The spike anchor presented some installation difficulties. Resin potted anchors worked well and were easy to install. For the one case considered (wedge anchor), it was determined that retensioning produces early failure and anchor-zone temperatures between -40 degrees C and +60 degrees C have no effect on system performance. Anchor seating losses during short-term use are in general small and could become insignificant depending on the length of the tendon. Copyright (C) 1996 Elsevier Science Ltd. C1 PENN STATE UNIV,UNIVERSITY PK,PA 16802. USACOE,WATERWAYS EXPT STN,VICKSBURG,MS. PROGRESS STRUCT,PLAINVILLE,CT. OI Nanni, Antonio/0000-0003-2678-9268 NR 12 TC 5 Z9 8 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD JUN PY 1996 VL 10 IS 4 BP 255 EP 266 DI 10.1016/0950-0618(95)00097-6 PG 12 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA UU656 UT WOS:A1996UU65600005 ER PT J AU English, JC Peake, MF Becker, LE AF English, JC Peake, MF Becker, LE TI Hepatitis C and porphyria cutanea tarda SO CUTIS LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; DIAGNOSIS; ASSOCIATION; MANAGEMENT; ANTIBODIES AB Porphyria cutanea tarda (PCT) is a clinical manifestation of decreased uroporphyrinogen decarboxylase (UPD) activity. Multiple endogenous and exogenous factors have been implicated in inducing PCT in genetically predisposed patients. The most recent is the RNA virus hepatitis C (HCV), which is transmitted via blood exposure. The mechanism of action in HCV-induced PCT is unknown but produces the same clinical, laboratory, and histopathologic changes seen in other forms of sporadic PCT. Therefore, patients presenting with PCT clinically should be tested serologically for antibodies against HCV and patients with HCV should be monitored for signs and symptoms of PCT. RP English, JC (reprint author), BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,BLDG 3600,3851 ROGER BROOKE DR,FT SAM HOUSTON,TX 78234, USA. NR 35 TC 11 Z9 11 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 1996 VL 57 IS 6 BP 404 EP 408 PG 5 WC Dermatology SC Dermatology GA UU584 UT WOS:A1996UU58400012 PM 8804842 ER PT J AU Honl, BA Keeling, JH Lewis, CW Thompson, IM AF Honl, BA Keeling, JH Lewis, CW Thompson, IM TI A pityriasis rosea-like eruption secondary to bacillus Calmette-Guerin therapy for bladder cancer SO CUTIS LA English DT Article ID COMPLICATIONS; IMMUNOTHERAPY; CARCINOMA; INFECTION; BCG AB The use of bacillus Calmette-Guerin (BCG) for the treatment of bladder cancer has been followed by reports documenting adverse reactions. Eruptions of the skin have been included (although not well described) in the list of side effects. We report a pityriasis rosea-like rash secondary to BCG therapy for bladder cancer. Although the treatment was interrupted because of this reaction, the medication was restarted later with only a mild transient recurrence of the eruption. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234. INDIANA UNIV,SCH MED,DEPT DERMATOL,BLOOMINGTON,IN. NR 16 TC 9 Z9 9 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 1996 VL 57 IS 6 BP 447 EP 450 PG 4 WC Dermatology SC Dermatology GA UU584 UT WOS:A1996UU58400022 PM 8804852 ER PT J AU May, J Kolm, KE AF May, J Kolm, KE TI Advanced techniques for solving groundwater contaminant problems - Preface SO ENGINEERING GEOLOGY LA English DT Editorial Material RP May, J (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,GG,YH,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD JUN PY 1996 VL 42 IS 2-3 BP 109 EP 109 DI 10.1016/0013-7952(96)89154-X PG 1 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA UX730 UT WOS:A1996UX73000001 ER PT J AU Albertson, PE Hennington, GW AF Albertson, PE Hennington, GW TI Groundwater analysis using a Geographic Information System following finite-difference and -element techniques SO ENGINEERING GEOLOGY LA English DT Article AB Groundwater analysis involves understanding both spatial and temporal changes. Changes in many different types of media have been modeled in the past with finite-difference and finite-element meshes. In the same way, groundwater can be represented as a finite-element analysis problem. This document describes the approach in which a Geographic Information System (GIS) was used to evaluate changes in groundwater levels resulting from a dam impoundment. This study focuses on areas of landuse impact caused by changes in groundwater conditions. A finite-element-type model created potentiometric steady-state surfaces. The computer software converted the finite elements to finite differences for raster based GIS multiconditional analysis. The raster GIS divided the study area into 50 m grid cells, approximately equal to the area of one acre. The study was limited to the alluvial valley boundary. Pre-dam and post-dam data sets were compared to evaluate causes and effects of the dam, and on landuse. Data sets were obtained for record lows and highs both before and after the dam was constructed. Analysis revealed the dam caused changes in the low groundwater regime but not in the high water levels. Once effects of the dam to the groundwater regime were understood, grid cells were compared against landuse critical threshold values to determine areas of probable impact. Graphic results included a series of potentiometric maps, pre-dam and post-dam depth to groundwater maps, cross valley groundwater profiles, effected areas maps, and possible impact maps. The GIS provided a management tool to select areas for future site specific assessment. RP Albertson, PE (reprint author), USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 7 TC 1 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD JUN PY 1996 VL 42 IS 2-3 BP 167 EP 173 DI 10.1016/0013-7952(95)00076-3 PG 7 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA UX730 UT WOS:A1996UX73000006 ER PT J AU May, JH Schmitz, DW AF May, JH Schmitz, DW TI Development of a predictive model for defining subsurface sand bodies SO ENGINEERING GEOLOGY LA English DT Article AB Numerous hazardous and toxic waste sites are underlain by sedimentary deposits. The delineation of buried paleochannels is a prime concern during the characterization of these sites. Buried paleochannels often provide direct conduits for contamination to move rapidly in the subsurface. Historically the method used to define a discontinuous sand body was to grid the entire area of interest and start drilling closely spaced holes. The grid pattern method is expensive and potentially hazardous. Geologists in the petroleum industry have developed techniques to predict the size, shape and orientation of subsurface sedimentary deposits by defining local environments of deposition of geologic materials within regional settings. Based on the depositional history of the paleochannel deposits empirical equations have been developed which allow for the calculation of channel depths as well as channel and meander belt widths. By combining geostatistics (kriging), paleogeomorphic studies and probability techniques, a predictive model was developed which has application in both ground water investigations and in oil and gas exploration. RP May, JH (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 16 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD JUN PY 1996 VL 42 IS 2-3 BP 175 EP 186 PG 12 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA UX730 UT WOS:A1996UX73000007 ER PT J AU Holland, JP AF Holland, JP TI Development of a ground-water modeling system for military installation restoration SO ENGINEERING GEOLOGY LA English DT Article AB The U.S. Army Engineer (USAE) Waterways Experiment Station is leading a multi-agency program which is developing an integrated, comprehensive groundwater modeling system in support of installation cleanup. Major aspects of this program include: evaluation of existing modeling technology, investigation of fate and transport mechanisms for military-unique compounds (e.g., explosives), investigation of the impacts of subsurface heterogeneities on remedial effectiveness, design of concise user environments for disparate users and models, and implementation of the models on differing computing platforms. An initial version of the groundwater modeling system has been developed for both UNIX workstations and personal computers running Windows 3.1. These products represent an initial step in the process and computational developments required to meet the military's and the nation's needs for characterization and remediation-oriented modeling. Continued development plans call for a focused combination of research in natural and remedial processes, heterogeneity-induced effects on fate, transport, remediation and computational sciences. RP Holland, JP (reprint author), USA,ENGINEER WATERWAYS EXPT STN,GROUNDWATER MODELING PROGRAM,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD JUN PY 1996 VL 42 IS 2-3 BP 205 EP 215 DI 10.1016/0013-7952(95)00091-7 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA UX730 UT WOS:A1996UX73000009 ER PT J AU Walsh, ME Collins, CM Racine, CH AF Walsh, ME Collins, CM Racine, CH TI Persistence of white phosphorus (P-4) particles in salt marsh sediments SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE white phosphorus; P-4; moisture; temperature; persistence AB Remediation of sediments at Eagle River Flats, Alaska, a salt marsh contaminated with solid particles of white phosphorus (P-4), may require severe alterations of the wetland by dredging, draining, or covering. However, some sediments may undergo decontamination naturally in areas that are seasonally subaerially exposed. The persistence of millimeter-size P-4 particles was studied in laboratory and field experiments. White phosphorus particles were found to be persistent in saturated sediments. In unsaturated sediments, loss was rapid (within 24 h) at 20 degrees C, and was retarded by low temperatures. RP Walsh, ME (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 19 TC 13 Z9 13 U1 0 U2 1 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUN PY 1996 VL 15 IS 6 BP 846 EP 855 DI 10.1897/1551-5028(1996)015<0846:POWPPP>2.3.CO;2 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA UP251 UT WOS:A1996UP25100005 ER PT J AU Cheng, TC Calomiris, JJ AF Cheng, TC Calomiris, JJ TI A cloned bacterial enzyme for nerve agent decontamination SO ENZYME AND MICROBIAL TECHNOLOGY LA English DT Article DE Alteromonas sp JD6.5; cloned OPA anhydrolase; decontamination; ammonium carbonate; chemical agents ID HYDROLYZING ENZYME AB Organophosphorus acid (OPA) anhydrolases offer considerable potential for safe, non-corrosive decontamination of chemical chemical nerve agents. The Alteromonas sp. strain JD6.5 gene encoding an OPA anhydrolase (designated as OPAA-2), which hydrolyzes a wide variety of nerve agents, has been cloned in Escherichia coli. Employing agent-analog diisopropyl fluorophosphate (DFP) as a substrate, the effects of buffers, pH, temperature, and various protein stabilizing agents on OPAA-2 activity were studied. Ammonium carbonate, which is innocuous and inexpensive, proved to be a superior buffer for enzyme activity. Compared with enzyme assayed under standard conditions, enzyme activity with ammonium carbonate was six-fold greater. To evaluate effects of storage and reconstitution on enzyme activity, the cloned enzyme was lyophilized, rehydrated, and then assessed by measuring activity against DFP. Whereas almost 100% of the hydrolytic activity was recovered with enzyme reconstituted in (NH4)(2)CO3-buffered distilled water or chlorinated drinking water, approximately 20% of the activity was recovered with ocean water. Enzyme stability in blast-containment foam or fire-fighting foam was also demonstrated by high activity in (NH4)(2)CO3-buffered distilled water or drinking water. These findings suggest the potential of a foam-based enzyme system for field decontamination of chemical nerve agents. RP Cheng, TC (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 20 Z9 21 U1 3 U2 5 PU BUTTERWORTH-HEINEMANN PI WOBURN PA 225 WILDWOOD AVE #UNITB PO BOX 4500, WOBURN, MA 01801-2084 SN 0141-0229 J9 ENZYME MICROB TECH JI Enzyme Microb. Technol. PD JUN PY 1996 VL 18 IS 8 BP 597 EP 601 DI 10.1016/0141-0229(95)00152-2 PG 5 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA UQ542 UT WOS:A1996UQ54200009 ER PT J AU Wang, HVC Chao, SY AF Wang, HVC Chao, SY TI Intensification of subtidal surface currents over a deep channel in the upper Chesapeake Bay SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE numerical model; subtidal current; deep channel; Chesapeake Bay AB A three-dimensional hydrodynamic model of the Upper Chesapeake Bay was used to examine the nature and cause of an intensification of subtidal, southward surface current in the middle reaches of the basin. The deep navigation channel along the eastern boundary was found to be ultimately responsible. The deep channel allows the density and tidally-induced subtidal currents to intensify over it, producing the eastern intensification. Both mechanisms operate in the non-rotating limit and consequently do not diminish with vanishing effect of the earth's rotation. Density-induced forcing is predominantly baroclinic, generating a northward undercurrent in the deep channel and a southward current aloft which attenuates westward. Tidal forcing is mostly barotropic, producing southward mean current in the deep channel and return flow to the west. Historic data lend support to the model results. (C) 1996 Academic Press Limited C1 UNIV MARYLAND,HORN POINT ENVIRONM LAB,CAMBRIDGE,MD 21613. RP Wang, HVC (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD JUN PY 1996 VL 42 IS 6 BP 771 EP 785 DI 10.1006/ecss.1996.0049 PG 15 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA UP578 UT WOS:A1996UP57800006 ER PT J AU Rauch, PJ Harrington, PD Davis, DM AF Rauch, PJ Harrington, PD Davis, DM TI Ion mobility spectrometer measures food flavor freshness SO FOOD TECHNOLOGY LA English DT Article C1 OHIO UNIV,CTR INTELLIGENT CHEM INSTRUMENTS,CLIPPINGER LABS,DEPT CHEM,ATHENS,OH 45701. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. OI Harrington, Peter/0000-0003-0268-8630 NR 4 TC 2 Z9 2 U1 0 U2 1 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0015-6639 J9 FOOD TECHNOL-CHICAGO JI Food Technol. PD JUN PY 1996 VL 50 IS 6 BP 83 EP 85 PG 3 WC Food Science & Technology SC Food Science & Technology GA UT451 UT WOS:A1996UT45100020 ER PT J AU Melloh, RA Crill, PM AF Melloh, RA Crill, PM TI Winter methane dynamics in a temperate peatland SO GLOBAL BIOGEOCHEMICAL CYCLES LA English DT Article AB Methane (CH4) dynamics in pore water, snow pore air, and surface emissions were investigated in a temperate poor fen in New Hampshire over several winters. Total snowfall and average air temperatures during winter months (defined as December, January, and February) were climatologic indicators of significant flux rates from this midlatitude poor fen. Average winter emissions, for the five winters ending in 1994-1995, were 20, 39, 53, 56, and 26 mg m(-2) d(-1) amounting to 2.0, 5.2, 6.6, 9.2, and 2.0% of the total annual fluxes, respectively. Totaling emissions over 5 years that represent low to average snowfall, winter accounted for 4.3% of emissions to the atmosphere. Winter flux rates were near 55 mg m(-2) d(-1) for years with average snowfall, and 25 mg m(-2) d(-1) for years with low snowfall. Concentrations of CH4 sampled in pore water immediately beneath the ice were highly variable (0 to 1.1 mM). The concentration magnitude and standard deviation increased toward the fen center and correlated with spatial variation in hydrology, peat texture, and peat depth. CH4 stores increased in the near-surface pore water as the ice cover formed. Seasonal CH4 buildup in deeper peat began near the end of the growing season, probably due to changing transport mechanisms and temperature effects on solubility. Stored CH4 in the 25- to 75-cm peat layer decreased by 2.7 g m(-2) between January and June 1995. C1 UNIV NEW HAMPSHIRE,INST STUDY EARTH OCEANS & SPACE,DURHAM,NH 03824. UNIV NEW HAMPSHIRE,DEPT EARTH SCI,DURHAM,NH 03824. RP Melloh, RA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. OI Crill, Patrick/0000-0003-1110-3059 NR 14 TC 68 Z9 76 U1 4 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0886-6236 J9 GLOBAL BIOGEOCHEM CY JI Glob. Biogeochem. Cycle PD JUN PY 1996 VL 10 IS 2 BP 247 EP 254 DI 10.1029/96GB00365 PG 8 WC Environmental Sciences; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences GA UP378 UT WOS:A1996UP37800004 ER PT J AU Lillis, P Thompson, IM AF Lillis, P Thompson, IM TI Should asymptomatic progression following definitive local treatment for prostate cancer be treated? SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID BEAM RADIATION-THERAPY; RADICAL PROSTATECTOMY; ANTIGEN LEVELS; ADENOCARCINOMA; RADIOTHERAPY; CARCINOMA; BIOPSY; IRRADIATION; SURGERY; MANAGEMENT AB Asymptomatic progression following definitive therapy for prostate cancer can take the form of a detectable prostate-specific antigen (PSA) or local recurrence following radical prostatectomy or a rising PSA or palpable recurrence following radiotherapy. Options for treatment include hormonal therapy, radiotherapy, salvage surgery, and experimental therapies. Although such forms of treatment have known effects on intermediate endpoints, such as reduction of PSA, the overall effect on survival and quality of life is uncertain. C1 BROOKE ARMY MED CTR,MCHE,SDU,RADIAT ONCOL SERV,DEPT RADIOL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234. NR 68 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD JUN PY 1996 VL 10 IS 3 BP 703 EP & DI 10.1016/S0889-8588(05)70362-2 PG 11 WC Oncology; Hematology SC Oncology; Hematology GA UP066 UT WOS:A1996UP06600013 PM 8773506 ER PT J AU Robson, M Dawson, N AF Robson, M Dawson, N TI How is androgen-dependent metastatic prostate cancer best treated? SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Review ID PHASE-III TRIAL; TREATMENT-OF-CANCER; PURE NONSTEROIDAL ANTIANDROGEN; LONG-TERM EXPERIENCE; PROGNOSTIC FACTORS; MEGESTROL-ACETATE; EUROPEAN-ORGANIZATION; CYPROTERONE-ACETATE; KETOCONAZOLE THERAPY; HORMONAL-THERAPY AB The median survival for men with systemic metastases from prostate cancer ranges between 2 and 3 years, depending primarily on the extent of disease at diagnosis. Androgen deprivation has been the mainstay of therapy since Huggins demonstrated its utility in 1941. It can be accomplished surgically or medically with essentially equivalent results. Newer modalities, such as combined androgen blockade, intermittent androgen blockade, and chemohormonal therapy, have not been shown to improve survival consistently. Subsets of patients, however, may derive additional benefit from these innovative therapies. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Robson, M (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,HEATON PAVIL,WARD 78,6900 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 149 TC 46 Z9 47 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD JUN PY 1996 VL 10 IS 3 BP 727 EP & DI 10.1016/S0889-8588(05)70364-6 PG 22 WC Oncology; Hematology SC Oncology; Hematology GA UP066 UT WOS:A1996UP06600015 PM 8773508 ER PT J AU Kingseed, CC AF Kingseed, CC TI To foreign shores: US amphibious operations in World War II - Lorelli,JA SO HISTORIAN LA English DT Book Review RP Kingseed, CC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 50 COLLEGE DR, ALLENTOWN, PA 18104-6100 SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 1996 VL 58 IS 4 BP 867 EP 868 PG 2 WC History SC History GA VU515 UT WOS:A1996VU51500029 ER PT J AU WHEELER, JS AF WHEELER, JS TI NAVY FINANCE, 1649-1660 SO HISTORICAL JOURNAL LA English DT Article RP WHEELER, JS (reprint author), US MIL ACAD, W POINT, NY 10996 USA. NR 16 TC 3 Z9 3 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0018-246X J9 HIST J JI Hist. J. PD JUN PY 1996 VL 39 IS 2 BP 457 EP 466 PG 10 WC History SC History GA UT445 UT WOS:A1996UT44500008 ER PT J AU Ahmad, F Razzaghi, M AF Ahmad, F Razzaghi, M TI Approximate solution to the envelope of a pulse propagating in a nonlinear optical fibre SO IEE PROCEEDINGS-OPTOELECTRONICS LA English DT Article DE Schrodinger equation; nonlinear optical fibre ID SCHRODINGER-EQUATION; PERTURBATION; SOLITONS AB An approximate solution of the unperturbed and perturbed nonlinear Schrodinger equation which is associated with an inverse problem is proposed. The solution of this nonlinear Schrodinger equation is the envelope of a pulse propagating through an optical fibre. Legendre-Gauss-Lobatto nodes are used to construct the Nth polynomial interpolation to approximate the solution of the envelope of the propagating pulse. An unperturbed and a perturbed example are given to demonstrate the accuracy of the proposed method. C1 MISSISSIPPI STATE UNIV,DEPT ELECT & COMP ENGN,MISSISSIPPI STATE,MS 39762. MISSISSIPPI STATE UNIV,DEPT MATH & STAT,MISSISSIPPI STATE,MS 39762. RP Ahmad, F (reprint author), USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 21 TC 6 Z9 6 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 1350-2433 J9 IEE P-OPTOELECTRON JI IEE Proc.-Optoelectron. PD JUN PY 1996 VL 143 IS 3 BP 200 EP 204 DI 10.1049/ip-opt:19960433 PG 5 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA UY188 UT WOS:A1996UY18800007 ER PT J AU Jacobs, R Christopher, H Hamlen, R Rizzo, R Paur, R Gilman, S AF Jacobs, R Christopher, H Hamlen, R Rizzo, R Paur, R Gilman, S TI Portable power source needs of the future army - Batteries and fuel cells SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB This paper describes the US Army's future needs for silent portable power in the area of batteries and fuel cells, These needs will continue to increase as a result of the introduction of newer types of equipment, the increasing digitization of the battlefield, and future integrated Soldier Systems. Current battery programs are aimed at improved, low-cost primary batteries, and rechargeable batteries with increased energy densities. The Army fuel cell program aimed at portable systems capable of the order of 150W is also described. C1 CECOM,FT MONMOUTH,NJ. USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,RES LAB,FT MONMOUTH,NJ. RP Jacobs, R (reprint author), CECOM,COMMUN ELECT COMMAND,FT BELVOIR,VA 22060, USA. NR 0 TC 5 Z9 5 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD JUN PY 1996 VL 11 IS 6 BP 19 EP 23 DI 10.1109/62.500206 PG 5 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA UN431 UT WOS:A1996UN43100005 ER PT J AU Bushnell, LG AF Bushnell, LG TI On the history of control SO IEEE CONTROL SYSTEMS MAGAZINE LA English DT Editorial Material RP Bushnell, LG (reprint author), USA,RES OFF,SYST & CONTROL PROGRAM,RES TRIANGLE PK,NC 27709, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0272-1708 J9 IEEE CONTR SYST MAG JI IEEE Control Syst. Mag. PD JUN PY 1996 VL 16 IS 3 BP 14 EP 16 DI 10.1109/MCS.1996.506393 PG 3 WC Automation & Control Systems SC Automation & Control Systems GA UP577 UT WOS:A1996UP57700005 ER PT J AU Cushing, MJ Krolewski, JG Stadterman, TJ Hum, BT AF Cushing, MJ Krolewski, JG Stadterman, TJ Hum, BT TI US Army reliability standardization improvement policy and its impact SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY PART A LA English DT Article ID PREDICTION RP Cushing, MJ (reprint author), USA,MAT SYST ANAL ACTIV,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1070-9886 J9 IEEE T COMPON PACK A JI IEEE Trans Compon. Packag. Manuf. Technol. Part A PD JUN PY 1996 VL 19 IS 2 BP 277 EP 278 DI 10.1109/95.506115 PG 2 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA UU444 UT WOS:A1996UU44400019 ER PT J AU Turner, TO Joyce, DC Yin, S Willson, PD Parnham, KB Glick, B AF Turner, TO Joyce, DC Yin, S Willson, PD Parnham, KB Glick, B TI Preliminary results obtained from novel CdZnTe pad detectors SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 1995 Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC) CY OCT 21-28, 1995 CL SAN FRANCISCO, CA AB CdZnTe pad detectors with a novel geometry and approximately 1 mm(2) pad sizes are being developed. These detectors have been specially designed for high energy resolution up to 300 keV energies. The contacts are produced through a unique technique developed by eV Products to achieve high reliability low resistance coupling to the substrate. A ceramic carrier is developed for low capacitance coupling of the detectors to NOVA's FEENA chip [1]. The detectors have been tested using the ultra low noise single and 3-channel amplifiers developed by eV Products. The CdZnTe detectors are tested for dark current. The charge energy resolutions and collection times are also measured using natural radiation sources. The measured detector parameters and the test results are showing that linear pad arrays can have good uniformity and excellent application potential for imaging x-rays and gamma-rays. The results obtained for the energy resolution are excellent for spectroscopy applications in nuclear physics, and the short charge collection time can be used for fast imaging. C1 EV PROD,SAXONBURG,PA 16056. USA,ARDEC,PICATINNY ARSENAL,NJ 07806. RP Turner, TO (reprint author), NOVA R&D INC,1525 3RD ST,SUITE C,RIVERSIDE,CA 92507, USA. NR 3 TC 5 Z9 5 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD JUN PY 1996 VL 43 IS 3 BP 1417 EP 1421 DI 10.1109/23.507076 PN 2 PG 5 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA UT044 UT WOS:A1996UT04400064 ER PT J AU Scozzie, CJ McGarrity, JM Blackburn, J DeLancey, WM AF Scozzie, CJ McGarrity, JM Blackburn, J DeLancey, WM TI Silicon carbide FETs for high temperature nuclear environments SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 1995 Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC) CY OCT 21-28, 1995 CL SAN FRANCISCO, CA AB SiC transistors can operate at very high temperatures and survive very high radiation doses. These characteristics make SiC potentially the ideal technology for nuclear power applications. In this paper we report, for the first time, on the active in-core irradiation of 6H-SiC depletion-mode junction field-effect transistors (JFETs) at 25 degrees and 300 degrees C in a nuclear reactor operated at 200 kW. No significant degradation in the device characteristics was observed until the total neutron fluence exceeded 10(15) n/cm(2) for irradiation at 25 degrees C, and no significant changes were observed even at 5 x 10(15) n/cm(2) at 300 degrees C. The results of this experiment may also indicate exciting evidence for the anneal of neutron displacement damage for devices irradiated at 300 degrees C. RP Scozzie, CJ (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 8 TC 12 Z9 14 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD JUN PY 1996 VL 43 IS 3 BP 1642 EP 1648 DI 10.1109/23.507163 PN 2 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA UT044 UT WOS:A1996UT04400106 ER PT J AU Levush, B Antonsen, TM Vlasov, AN Nusinovich, GS Miller, SM Carmel, Y Granatstein, VL Destler, WW Bromborsky, A Schlesiger, C Abe, DK Ludeking, L AF Levush, B Antonsen, TM Vlasov, AN Nusinovich, GS Miller, SM Carmel, Y Granatstein, VL Destler, WW Bromborsky, A Schlesiger, C Abe, DK Ludeking, L TI High-efficiency relativistic backward wave oscillator: Theory and design SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB Backward wave oscillators (BWO's) driven by high-current relativistic electron beams are capable of producing high-power coherent radiation in the centimeter and millimeter wavelength regions, However, the efficiency of these devices is usually limited to 15-20% when a homogeneous slow-wave structure is used, Utilizing a two-section slow-wave structure, where the spatial period of the second section is larger than that bf the first section, a BWO efficiency of greater than 50% was calculated, A conceptual design of a high efficiency S-band BWO driven by a 500-kV 5-kA electron beam has been developed and analyzed. C1 UNIV MARYLAND,COLLEGE PK,MD 20742. USA,RES LAB,ADELPHI,MD 20783. MISSION RES CORP,NEWINGTON,VA 22122. RI Abe, David/D-7546-2013; Antonsen, Thomas/D-8791-2017 OI Antonsen, Thomas/0000-0002-2362-2430 NR 17 TC 21 Z9 22 U1 3 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JUN PY 1996 VL 24 IS 3 BP 843 EP 851 DI 10.1109/27.533087 PG 9 WC Physics, Fluids & Plasmas SC Physics GA VE084 UT WOS:A1996VE08400034 ER PT J AU Brandt, HE AF Brandt, HE TI Current modulation in relativistic klystron amplifiers SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB A brief review is first provided of the assumptions and approximations involved in Uhm's recent theory of current modulation in klystron amplifiers. Next, this theory is employed to obtain a solution to a cubic equation that approximates the klystron drift distance to the point of maximum current modulation, and also to obtain the corresponding current modulation amplitude in terms of relevant klystron parameters. RP Brandt, HE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 4 TC 9 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JUN PY 1996 VL 24 IS 3 BP 924 EP 927 DI 10.1109/27.533096 PG 4 WC Physics, Fluids & Plasmas SC Physics GA VE084 UT WOS:A1996VE08400043 ER PT J AU Bromborsky, A AF Bromborsky, A TI The multiplet cavity: A buncher for broad-bandwidth klystron amplifiers SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB The bandwidth of a klystron output cavity scales (approximately) as p(0.8)P(0.2), where p is the beam perveance and P is the beam power [1], [2] For high-perveance (p > 10 mu pervs) high-power (P > 10 kW) electron beams, it is relatively straightforward to design a broad-band output cavity, However, the design of the input cavity of the broad-band klystron is in some ways more difficult. The purpose of the input cavity is to produce a velocity-modulated electron beam with a frequency-dependent modulation amplitude that will optimize the bandwidth of the entire klystron system, while providing a magnitude of velocity modulation large enough to minimize the length of the klystron. This paper shows how a multiplet (multiple cavity) buncher cavity can be designed to provide broad-band (>20%) operation while keeping short the drift section length of the klystron. RP Bromborsky, A (reprint author), USA,RES LAB,NH,WT,AMSRL,ADELPHI,MD 20783, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JUN PY 1996 VL 24 IS 3 BP 928 EP 934 DI 10.1109/27.533097 PG 7 WC Physics, Fluids & Plasmas SC Physics GA VE084 UT WOS:A1996VE08400044 ER PT J AU Schwartz, DH Viscidi, R Laeyendecker, O Song, HF Ray, SC Michael, N AF Schwartz, DH Viscidi, R Laeyendecker, O Song, HF Ray, SC Michael, N TI Predominance of defective proviral sequences in an HIV plus long-term non-progressor SO IMMUNOLOGY LETTERS LA English DT Article; Proceedings Paper CT 1st International Summit on Immunological Correlates of Protection from HIV Infection and Disease CY 1995 CL LE MT PELERIN, SWITZERLAND SP EC Centralized Facil Preclin HIV 1 Vaccine Dev DE non-progressor; provirus; env V3 region AB We examined the accessory genes and envelope V3 region of provirus obtained over a 5 year period from an HIV+ long-term non-progressor with very low viral load and no in vitro recoverable virus during that same time span. LTR sequences supported normal Tat-mediated promoter activity. Multiple clones of nef sequences were highly conserved with < 10% containing frame shift or stop codon mutations. Functional analysis of the predominant nef sequence indicated wild type downregulation of surface CD4 and good function in a complementation infectivity assay. By contrast, inactivating mutations were found in 64% of amplicons containing vif, vpi, vpu, tat1, and rev1, and in 41% of amplicons containing env V3. Identical inactive sequences were obtained at an interval of 2 years, suggesting persistence of quiescent defective provirus in a long-lived clonal cell population. Furthermore, generic distance versus time analysis revealed an absence of progressive evolution or arborization of quasispecies over time. This contrasts with data generated from other asymptomatic HIV+ individuals. The non-progressive pattern of ena sequence diversity and low R(2) for genetic divergence over time suggests that the defective provirus circulating in the periphery of this patient represents a randomly sampled 'fossil record' of earlier replication competent HIV-1 genomes. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV PEDIAT,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21205. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. RP Schwartz, DH (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Laeyendecker, Oliver/B-9331-2009; Ray, Stuart/B-7527-2008 OI Ray, Stuart/0000-0002-1051-7260 NR 8 TC 15 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD JUN PY 1996 VL 51 IS 1-2 BP 3 EP 6 DI 10.1016/0165-2478(96)02547-3 PG 4 WC Immunology SC Immunology GA UW653 UT WOS:A1996UW65300002 PM 8811337 ER PT J AU Hase, T Jett, M AsafoAdjei, E Topper, M AF Hase, T Jett, M AsafoAdjei, E Topper, M TI Release of chromaffin granular content from Staphylococcal enterotoxin B (SEB)-treated and -untreated PC12 cells SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Article DE chromaffin granule; electron microscopy; PC12 cell; Staphylococcal enterotoxin B(SEB) ID NERVE GROWTH-FACTOR; PHEOCHROMOCYTOMA CELLS; LINE; SYNEXIN; CALCIUM; STORAGE AB The release of chromaffin granular content from staphylococcal enterotoxin B (SEB)-treated and -untreated PC12 cells was studied by electron microscopy. The treatment of the cells with SEE at the concentration of 20 mu g/ml caused marked increase of the chromaffin granules that either bound to the plasma membrane by the characteristic rods, measuring 15 to 20 nm in length and showing a tubular structure, or budded off at the free cell surface, surrounded by a layer of rod-containing cytoplasm and enclosed by the plasma membrane. The binding between the granular and plasma membranes by the rods did not lead to membrane fusion and exocytosis of the granular content, Many of the bound granules showed vesiculation with loss of the electron-dense core material; at the same time. some of the binding rods contained intraluminal electron-dense material similar to the granular core material. These findings suggested that the electron-dense material (i.e., norepinephrine) of the bound granules was released extracellularly through channels within the rods. Although the granules were bound to the plasma membrane with equal frequency at the free and contiguous cell surfaces, the granular budding occurred only al the free cell surface, indicating that it occurred incidentally to some granules bound at the free cell surfaces. On the basis of the morphological observations, it is postulated that the electron-dense material of the bound granule is selectively released extracellularly through the rods, leaving the vesiculated granules behind in the cytoplasm. The same mode of release of the granular content was observed, though less frequently, in the untreated control cells. No morphological evidence that indicated that the granular content was released extracellularly by exocytosis was found in the treated and control cells. The present observations indicated that the SEE treatment of PC12 cells stimulated the binding of chromaffin granules to the plasma membrane by the rods and the budding of the bound granules at the free cell surface. C1 WALTER REED ARMY INST RES,DEPT MOLEC PATHOL,WASHINGTON,DC 20307. RP Hase, T (reprint author), WALTER REED ARMY INST RES,DEPT ULTRASTRUCT PATHOL,WASHINGTON,DC 20307, USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU SOC IN VITRO BIOLOGY PI COLUMBIA PA 8815 CENTRE PARK DRIVE SUITE 210, COLUMBIA, MD 21045 SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUN PY 1996 VL 32 IS 6 BP 322 EP 328 PG 7 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA UX749 UT WOS:A1996UX74900005 PM 8842746 ER PT J AU Meier, HL Clayson, ET Kelly, SA Corun, CM AF Meier, HL Clayson, ET Kelly, SA Corun, CM TI Effect of sulfur mustard (HD) on ATP levels of human lymphocytes cultured in vitro SO IN VITRO TOXICOLOGY LA English DT Proceedings Paper CT OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods CY JAN 22-24, 1996 CL SOLNA STOCKHOLM, SWEDEN SP OECD ID CHEMICAL WEAPONS; NAD+ LEVELS; NICOTINAMIDE; TOXICITY AB These studies were conducted to determine the effects of sulfur mustard (HD) on int cellular ATP levels of human lymphocytes. Preparations of human lymphocytes, isolate from the blood of volunteers, were exposed to dilute concentrations of HD (1 x 10(-5) to 1 x 10(-3) M), incubated at 37 degrees C for 0-20 h and lysed. ATP content of the lysates was determined by a commercially available bioluminescence assay and. a luminometer. Intracellular ATP levels in human lymphocytes exposed to HD were found to be dependent on both the concentration of HD and the time post-exposure to HD. Intracellular ATP levels began to decrease by 0.5 h and decreased steadily over the first 4 h after exposure, At 2 h post-exposure a near linear decrease in ATP levels was observed at HD concentrations between 3 x 10(-5) and 3 x 10(-4) M. Both niacinamide and 3-aminobenzamide [inhibitors of poly(ADP-ribose) polymerase] were found to be effective at reducing the HD-induced loss in intracellular ATP levels. These results support the hypothesis that poly(ADP-ribose) polymerase plays a role in HD-induced cellular changes. RP Meier, HL (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 8 Z9 8 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0888-319X J9 IN VITRO TOXICOL JI In Vitro Toxicol. PD SUM PY 1996 VL 9 IS 2 BP 135 EP 139 PG 5 WC Toxicology SC Toxicology GA VD312 UT WOS:A1996VD31200003 ER PT J AU Rajnik, S Mitchell, W AF Rajnik, S Mitchell, W TI Effects of 2,4,6-trinitrotoluene and associated munitions on HSP72/73 production in a human lymphoblast cell line SO IN VITRO TOXICOLOGY LA English DT Proceedings Paper CT OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods CY JAN 22-24, 1996 CL SOLNA STOCKHOLM, SWEDEN SP OECD ID NITROAROMATIC COMPOUNDS; PROTEINS AB Nitroaromatic compounds associated with the munitions industry are a potential threat to human health and the environment. The effect of 2,4,6-trinitrotoluene (2,4,6-TNT) and. several related munitions on 72/73 kDa stress protein (HSP72/73) production in TK6 continuous human lymphoblasts has been studied as a potential exposure marker. Based on Western blot analysis, production of HSP72/73 was stimulated by 2,4,6-TNT; however, enhanced expression of the proteins required explosive concentrations that are also growth inhibitory. Levels of HSP72/73 in lymphoblast cultures treated with 2,4,6-TNT appeared to be consistently lower than those stimulated by heat shock but somewhat greater than amounts found, after exposure to the inducer ethanol. Since ethanol is also inhibitory to the cell system, reduced amounts of HSP72/73 in 2,4,6-TNT treated as compared to heat-shocked cultures could be attributed to cytotoxicity. Under conditions in which 2,4,6-TNT stimulated HSP72/73 synthesis, four other nitroaromatic compounds associated with its manufacture had no apparent effect on production of the stress proteins. Results suggest that despite restricted stimulation by 2,4,6-TNT in TK6 cells, enhancement of HSP72/73 would likely be limited as a general biomarker for nitroaromatic compounds. RP Rajnik, S (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,FREDERICK,MD 21702, USA. NR 23 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0888-319X J9 IN VITRO TOXICOL JI In Vitro Toxicol. PD SUM PY 1996 VL 9 IS 2 BP 183 EP 190 PG 8 WC Toxicology SC Toxicology GA VD312 UT WOS:A1996VD31200009 ER PT J AU Andrews, GP Heath, DG Anderson, GW Welkos, SL Friedlander, AM AF Andrews, GP Heath, DG Anderson, GW Welkos, SL Friedlander, AM TI Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge SO INFECTION AND IMMUNITY LA English DT Article ID Y-PESTIS; GENE; PROTEIN AB As a first step in formulating an improved plague vaccine, we developed a simple purification strategy that produced high yields of pure cell-associated and culture supernatant-derived fraction 1 capsular antigen (F1) from both avirulent Yersinia pestis CO92 (Pgm(-) Lcr(-)) and an Escherichia coli F1-producing recombinant strain. Cell-associated F1 was partially purified by sequential ammonium sulfate precipitations of a sodium chloride extract of acetone-dried bacteria harvested from broth cultures. Cell-free F1 was precipitated directly from culture supernatants with a single application of 30% ammonium sulfate. F1 exploiting the aggregative property of F1, large quantities of purified high-molecular-weight F1 species from both cell extracts and supernatants were isolated in the void volume of a preparative gel filtration column. Highly purified, endotoxin-free FI, combined with two different adjuvants, induced very high F1 titers in mice and protected them against either subcutaneous (70 to 100% survival) or aerosol (65 to 84% survival) challenge with virulent organisms. This protection was independent of the source of the antigen and the adjuvant used. F1-induced protection against both subcutaneous and aerosol challenge was also significantly better than that conferred by immunization with the licensed killed whole-cell vaccine. Our results indicate that F1 antigen represents a major protective component of previously studied crude capsule preparations, and immunity to F1 antigen provides a primary means for the host to overcome plague infection by either the subcutaneous or respiratory route. RP Andrews, GP (reprint author), USA,MED RES INST INFECT DIS,BACTERIOL DIV,FT DETRICK,FREDERICK,MD 21702, USA. NR 42 TC 144 Z9 158 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1996 VL 64 IS 6 BP 2180 EP 2187 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UN189 UT WOS:A1996UN18900042 PM 8675324 ER PT J AU Crawford, RM VandeVerg, L Yuan, L Hadfield, TL Warren, RL Drazek, ES Houng, HSH Hammack, C Sasala, K Polsinelli, T Thompson, J Hoover, DL AF Crawford, RM VandeVerg, L Yuan, L Hadfield, TL Warren, RL Drazek, ES Houng, HSH Hammack, C Sasala, K Polsinelli, T Thompson, J Hoover, DL TI Deletion of purE attenuates Brucella melitensis infection in mice SO INFECTION AND IMMUNITY LA English DT Article ID BALB/C MICE; ABORTUS; STRAINS; INTERLEUKIN-1 AB We previously showed that a purE mutant (Delta purE201) of Brucella melitensis 16M is attenuated for growth in cultured human monocytes (E. S. Drazek, H. H. Houng, R. M. Crawford, T. L. Hadfield, D. L. Hoover, and R. L. Warren, Infect. Immun. 63:3297-3301, 1995). To determine if this strain is attenuated in animals, we compared the growth of the Delta purE201 mutant with that of strain 16M in BALB/c mice. The number of bacteria in the spleen and spleen weight peaked for both strains between 1 and 2 weeks postinfection (p.i.), though the number of Delta purE201 cells was significantly less than the number of 16M cells recovered from the spleens of infected mice. During the next 6 weeks, Delta purE201 was essentially eliminated from infected mice (three of five mice sterile; < 100 CFU in two of five mice at 8 weeks p.i.), whereas bacteria persisted at a high level in the spleens of 16M-infected mice (about 10(6) CFU per spleen). The number of bacteria in the livers and lungs of mice infected with either strain paralleled those in the spleen. Mice infected with 16M had a strong inflammatory response, developing dramatic and prolonged splenomegaly (five to eight times normal spleen weight) and producing serum interleukin-6. In contrast, mice infected with Delta purE201 developed only mild, transient splenomegaly at 1 week p.i. and produced no interleukin-6 in their serum. We further characterized the host response to infection by measuring changes in immune spleen cell populations by flow cytometry. CD4- and CD8-positive lymphocytes declined by 1 week in both experimental groups, while MAC-1-positive cells increased. T-cell subpopulations remained low or declined further, and MAC-1 cells increased to three times normal levels during 8 weeks of infection with 16M but returned to normal by 4 weeks after infection with Delta purE201. These results document infectivity and attenuation of Delta purE201 and suggest that it should be further evaluated as a potential vaccine. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. RP Crawford, RM (reprint author), ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS PATHOL,WASHINGTON,DC 20306, USA. NR 19 TC 68 Z9 68 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1996 VL 64 IS 6 BP 2188 EP 2192 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UN189 UT WOS:A1996UN18900043 PM 8675325 ER PT J AU Fleckenstein, JM Kopecko, DJ Warren, RL Elsinghorst, EA AF Fleckenstein, JM Kopecko, DJ Warren, RL Elsinghorst, EA TI Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli SO INFECTION AND IMMUNITY LA English DT Article ID UNDIFFERENTIATED HUMAN DIARRHEA; EPITHELIAL-CELL INVASION; TISSUE-CULTURE CELLS; CYTOPLASMIC MEMBRANE; ENHANCED TOXICITY; BACTERIOPHAGE-MU; DNA FRAGMENTS; PROTEIN; COLONIZATION; CLONING AB Enterotoxigenic Escherichia call (ETEC) shares with other diarrheal pathogens the capacity to invade epithelial cell lines originating from the human ileum or colon, although the role of invasion in ETEC pathogenesis remains undefined. Two distinct loci (tia and tib) that direct noninvasive E. coli to adhere to and invade intestinal epithelial cell lines have previously been isolated from cosmid libraries of the classical ETEC strain H10407. Here, we report the molecular characterization of the tia locus. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of cellular fractions of E. coli DH5 alpha carrying the tia-positive cosmids and recombinant plasmid subclones revealed that this locus directs the production of a 25-kDa protein (the Tia protein) that is localized to the outer membrane. The tia locus was subcloned to a maximum of 2 kb and mutagenized with bacteriophage Mud. Synthesis of this protein was directly correlated with the ability of subclones and Mud transposon mutants to adhere to and invade epithelial cells. Sequencing of the tia locus identified a 756-bp open reading frame. All transposon insertions resulting in an invasion-negative phenotype mapped to this open reading frame. The open reading frame was amplified and directionally cloned behind the inc promoter of pHG165. This construct directed DH5 alpha to express a 25-kDa protein and to adhere to and invade epithelial cells. The role of the tia gene in directing epithelial adherence and invasion was further assessed by the construction of chromosomal tia deletion derivatives of the parent ETEC strain, H10407. These tia deletion strains were noninvasive and lacked the ability to adhere to human ileocecal cells. The tia gene shares limited homology with the Yersinia ail locus and significant homology with the hra1 agglutinin gene cloned from a porcine ETEC strain. Additionally, tia probes hybridized to geographically diverse ETEC strains, as well as some enteropathogenic E. coli, enteroaggregative E. coli, and Shigella sonnei strains. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. US FDA,LAB ENTER & SEXUALLY TRANSMITTED DIS,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. UNIV KANSAS,DEPT MICROBIOL,LAWRENCE,KS 66045. RP Fleckenstein, JM (reprint author), WALTER REED ARMY MED CTR,DIV INFECT DIS,DEPT MED,WASHINGTON,DC 20307, USA. OI Fleckenstein, James/0000-0002-1148-697X NR 54 TC 76 Z9 76 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1996 VL 64 IS 6 BP 2256 EP 2265 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UN189 UT WOS:A1996UN18900053 PM 8675335 ER PT J AU Elsayed, NM AF Elsayed, NM TI In memory of Professor Mohammad C. Mustafa SO INHALATION TOXICOLOGY LA English DT Item About an Individual C1 UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024. RP Elsayed, NM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JUN-JUL PY 1996 VL 8 IS 5 BP R3 EP R4 PG 2 WC Toxicology SC Toxicology GA UR083 UT WOS:A1996UR08300001 ER PT J AU Gazonas, GA Segletes, SB Boyle, VM Stegall, SR AF Gazonas, GA Segletes, SB Boyle, VM Stegall, SR TI Oblique impact modeling of fuzes SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article ID CANTILEVER AB This paper presents the results of a combined experimental, numerical, and analytical investigation of a low-speed (198 m/s) oblique impact of a cylindrical steel projectile into an aluminum-brass composite fuze simulant. The numerical simulations were performed prior to the experiments using the Lagrangian hydrocode EPIC92. The results indicate that projectile hardness and impact point strongly influence the mechanism by which the fuze deforms. An experiment was then conducted in order to evaluate the predictive capabilities of the hydrocode. The experimental results generally corroborate the hydrocode results during the initial stages of the impact but depart significantly at later stages of the penetration. Possible causes for the observed differences between the experiment and the simulation include, (i) the absence of a global fracture modeling capability in the hydrocode, and (ii) boundary condition differences between experiment and simulation. The hydrocode predicts that 91% of the projectile kinetic energy is converted into target plastic work. This result compares well with predictions based upon an analytical model of an elastic-plastic beam bent by an end load. RP Gazonas, GA (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. OI Gazonas, George/0000-0002-2715-016X NR 27 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUN PY 1996 VL 18 IS 4 BP 435 EP 457 DI 10.1016/0734-743X(95)00042-9 PG 23 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA UC897 UT WOS:A1996UC89700007 ER PT J AU Erdogan, MU Sankaran, V Kim, KW Stroscio, MA Iafrate, GJ AF Erdogan, MU Sankaran, V Kim, KW Stroscio, MA Iafrate, GJ TI Optical properties of ultrathin GaAs/AlAs quantum well structures with an electric field SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SUPERLATTICES; GAAS; SEMICONDUCTORS; ALAS AB A theoretical study of the optical properties of GaAs/AlAs quantum well structures in the presence of an electric field is presented. In the first part of the article, interband transitions from the valence band to the conduction band are studied near the type-I to type-II transition point. In the second part, the effect of the electric field on intersubband transitions within the conduction band is considered. The band structure is calculated using a second-nearest-neighbor empirical sp(3) tight binding method including spin-orbit effects. Interband and intersubband transition energies, optical matrix elements, and absorption coefficients are given as functions of the electric field. It is shown that the optical properties of these structures can be modified significantly with field near the anticrossing point. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Erdogan, MU (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 1 PY 1996 VL 79 IS 11 BP 8675 EP 8681 PG 7 WC Physics, Applied SC Physics GA UN852 UT WOS:A1996UN85200086 ER PT J AU Halle, JS Kukulka, CG AF Halle, JS Kukulka, CG TI Response of human soleus single motor units to changes in joint position and intensity of peroneal nerve stimulation SO JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY LA English DT Article DE motor neuron; motor units; reflex; heteronymous excitation; interneuron ID RECIPROCAL IA INHIBITION; REFLEX RESPONSES; H-REFLEX; VOLUNTARY CONTRACTION; SYNAPTIC CONNECTIONS; AFFERENT STIMULATION; MUSCLE; FACILITATION; MOTONEURONS; DEPRESSION AB This research examined the correlation between peroneal nerve stimulation and the response of voluntarily recruited rhythmically firing soleus motor units (MUs). Two hundred and twenty-five MUs were recorded in 10 neurologically normal adult subjects, eight men and two women (mean age 32.3 yr). The investigation complemented previous research by re-examining reciprocal innervation patterns while controlling for the effects of two levels of stimulation (0.9 and 1.25 motor threshold) and two ankle positions (15 degrees and 45 degrees of plantarflexion). Motor unit responses were assessed by peristimulus time histogram (PSTH) analysis and a cumulative sum (CUSUM) procedure. The responses were grouped into five categories according to latency values and the sign of the firing-rate response. Results demonstrated stimulus intensity effects for all categories except the short latency (28-48 ms) facilitatory response category (P < 0.05). No effects attributed solely to ankle position were demonstrated. Cutaneous afferents were not found to contribute to the response at the lower stimulus intensity, but significant effects were observed at 1.25 motor threshold. Latency values indicate that reciprocal inhibition, reciprocal excitation, and/or heteronymous excitation occur at the spinal cord level. The concept of reciprocal excitation is questioned. Possible physiological mechanisms associated with short latency excitations and inhibitions are discussed. C1 ITHACA COLL, DEPT PHYS THERAPY, ROCHESTER, NY 14623 USA. RP Halle, JS (reprint author), USA, WAR COLL, ARMY PHYS FITNESS RES INST, CARLISLE, PA 17013 USA. NR 44 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1050-6411 J9 J ELECTROMYOGR KINES JI J. Electromyogr. Kinesiol. PD JUN PY 1996 VL 6 IS 2 BP 97 EP 109 DI 10.1016/1050-6411(95)00023-2 PG 13 WC Neurosciences; Physiology; Rehabilitation; Sport Sciences SC Neurosciences & Neurology; Physiology; Rehabilitation; Sport Sciences GA UU482 UT WOS:A1996UU48200003 PM 20719667 ER PT J AU Augsburger, RA Wong, MT AF Augsburger, RA Wong, MT TI Pulp management in dens evaginatus SO JOURNAL OF ENDODONTICS LA English DT Article AB A 12-yr-old Guamanian girl presented with seven premolars displaying dens evaginatus. The pulp of one tooth was necrotic secondary to fracture of the evagination. Calcium hydroxide treatment was used to induce closure of this root apex, and subsequent routine canal obturation resulted in clinical success, Three teeth had fractured evaginations and compromised coronal pulps, but the radicular pulp tissue was vital. Coronal calcium hydroxide pulpotomy procedures were performed, and root development continued on all three teeth, In one of these teeth, endodontic treatment was completed, and in the other two the radicular pulp remained vital, Three teeth had intact evaginations and vital pulps, In an attempt to protect these evaginations from trauma, composite reinforcements were placed around the evaginations. These pulps remained vital and the roots completed normal development, Early diagnosis and treatment should be sought in cases of dens evaginatus to provide the greatest opportunity for complete root development. C1 OFF ASSIST SECRETARY DEF HLTH AFFAIRS,WASHINGTON,DC. USA,MED DEPT CTR & SCH,DENT LAB BRANCH,SAN ANTONIO,TX. NR 10 TC 5 Z9 5 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1996 VL 22 IS 6 BP 323 EP 326 DI 10.1016/S0099-2399(96)80269-X PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UN512 UT WOS:A1996UN51200012 PM 8934995 ER PT J AU Opal, SM Horn, DL Palardy, JE Parejo, N Jhung, J Bhattacharjee, A Young, LD AF Opal, SM Horn, DL Palardy, JE Parejo, N Jhung, J Bhattacharjee, A Young, LD TI The in vivo significance of antibiotic-induced endotoxin release in experimental Gram-negative sepsis SO JOURNAL OF ENDOTOXIN RESEARCH LA English DT Article ID ESCHERICHIA-COLI; BACTERIAL SEPSIS; LIPOPOLYSACCHARIDE; INVITRO; THERAPY AB Considerable evidence now supports the experimental findings that penicillin-binding protein (PBP)-2 specific antimicrobial agents such as imipenem generate less endotoxin than PBP-5 specific agents such as ceftazidime during the process of bacteriolysis of Gram-negative bacteria. To determine if differences in endotoxin release have pathophysiologic significance in vivo, Sprague-Dawley rats were experimentally challenged with intraperitoneal injections of virulent, serum-resistant clinical strains of the following Gram-negative bacilli: Escherichia Coli O18:K1, Klebsiella pneumoniae K2, and Pseudomonas aeruginosa 12.4.4 (immune type 6). After intravenous administration of imipenem (25 mg/kg), ceftazidime (50 mg/kg) or saline control, imipenem and ceftazidime-treated animals had rapid reductions in the quantitative level of bacteremia from all three pathogens. Peritoneal fluid samples revealed spherical forms with imipenem and long, filamentous forms with ceftazidime. Circulating plasma endotoxin levels were consistently higher (P <0.05) with ceftazidime than imipenem for 6 h after administration of E. coli or P. aeruginosa intraperitoneal challenge. Endotoxin levels were unchanged to slightly higher with imipenem than ceftazidime following K. pneumoniae intraperitoneal challenge. TNF levels peaked 2 h post-therapy and were consistently higher with ceftazidime-treated animals (P <0.05). D-galactosamine-treated animals had LD,, values that were 0.5-2 log higher (P <0.001) with imipenem for E. coli and P. aeruginosa but did not differ from ceftazidime in animals challenged with the K. pneumoniae strain. These results indicate that the PBP-2 specific agent imipenem led to significantly less endotoxin release than did ceftazidime with its great affinity to PBP-3. Differential endotoxin release was found after antimicrobial therapy with the E. coli and P. aeruginosa strains but not with the K. pneumoniae strain tested in this study. The clinical relevance of these findings with treatment of systemic Gram-negative infections in humans will require further clinical investigation. C1 BROWN UNIV, SCH MED, DIV INFECT DIS, PROVIDENCE, RI 02912 USA. BROWN UNIV, SCH MED, DIV PATHOL, PROVIDENCE, RI 02912 USA. MERCK US HUMAN HLTH DIV, W POINT, PA USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. RP Opal, SM (reprint author), MEM HOSP, DIV INFECT DIS, 111 BREWSTER ST, PAWTUCKET, RI 02860 USA. NR 22 TC 14 Z9 14 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-0519 J9 J ENDOTOXIN RES JI J. Endoxtin Res. PD JUN PY 1996 VL 3 IS 3 BP 245 EP 252 PG 8 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA VR081 UT WOS:A1996VR08100010 ER PT J AU Velleux, M Gailani, J Endicott, D AF Velleux, M Gailani, J Endicott, D TI Screening-level approach for estimating contaminant export from tributaries SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID SORPTIVE TOXIC-SUBSTANCES; FRESH-WATER SYSTEMS; MODELS; LAKES AB The in-place pollutant export model (IPX) is a screening-level model for estimating contaminant export from tributaries with contaminated sediments to receiving waterbodies. IPX is a modified version of the USEPA's WASP4 modeling framework. IPX synthesizes sediment transport processes for sediment aging, decreased sediment resuspendability with increasing age, and resuspension of freshly deposited sediments as a function of water velocity, into an expanded WASP4 contaminant transport and fate chassis while retaining the computational flexibility of the original framework. These process descriptions are needed to accurately simulate contaminant transport and substantially improve the framework for application to tributary systems subject to significant deposition and resuspension events. The potential for applying IPX is broad; water quality impairments attributable to contaminated sediments are widespread due to discharges from industry, agriculture, and mining and ore processing. IPX has been successfully applied to the upper and lower Fox River in Wisconsin,and the Buffalo and Oswego Rivers in New York, all impaired by contaminated sediments. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. US EPA,LARGE LAKES RES STN,GROSSE ILE,MI 48138. RP Velleux, M (reprint author), WISCONSIN DEPT NAT RESOURCE,WR-2,POB 7921,MADISON,WI 53707, USA. NR 28 TC 3 Z9 3 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD JUN PY 1996 VL 122 IS 6 BP 503 EP 514 DI 10.1061/(ASCE)0733-9372(1996)122:6(503) PG 12 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA UM374 UT WOS:A1996UM37400009 ER PT J AU Phelps, S AF Phelps, S TI Fort Knox combats roaches with heat SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT News Item RP Phelps, S (reprint author), USA,CTR ENVIRONM,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSN PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80222 SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JUN PY 1996 VL 58 IS 10 BP 29 EP 30 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA UM907 UT WOS:A1996UM90700010 ER PT J AU Hornbach, DJ Deneka, T Payne, BS Miller, AC AF Hornbach, DJ Deneka, T Payne, BS Miller, AC TI Shell morphometry and tissue condition of Amblema plicata (Say, 1817) from the upper Mississippi River SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID GROWTH; CLAM; UNIONIDAE; BIOMASS; LAKE AB We examined shell length-weight relationships and shell shape in the unionid Amblema plicata (Say, 1817) from Pool 10 through Pool 26 of the upper Mississippi River. There were differences in both the intercepts and slopes of the relationships between size and other measured characteristics among the various pools examined. There was a much greater degree of variability in the tissue related factors than in any of the shell factors. There were no apparent upstream-downstream trends in any of the dependent variables. We also found that the shell can contain a significant amount of organic material and the percentage of organic material varied considerably, particularly in larger mussels. This indicates the need to consider the shell in studies of the energy dynamics of unionids. Tissue condition varied with mussel size; larger mussels had proportionally lighter shells and thus higher condition indices than smaller mussels. Because of the significant intra- and inter-pool variability in shell and tissue parameters which we observed, we urge that biomass estimates based on shell length-weight regressions for this and other species should be based on empirical relationships observed for the particular population under study rather than from literature values. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP Hornbach, DJ (reprint author), MACALESTER COLL,DEPT BIOL,ST PAUL,MN 55105, USA. NR 24 TC 4 Z9 4 U1 0 U2 1 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 1996 VL 11 IS 2 BP 233 EP 240 DI 10.1080/02705060.1996.9663483 PG 8 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA UH818 UT WOS:A1996UH81800014 ER PT J AU George, SG Dickerson, DD Reine, KJ AF George, SG Dickerson, DD Reine, KJ TI Rediscovery of the inflated heelsplitter mussel, Potamilus inflatus, from the Pearl River drainage SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article AB The inflated heelsplitter mussel, Potamilus inflatus (Lea, 1881) an endemic freshwater mussel of the eastern Gulf coast drainage, was rediscovered in the West Pearl River, Louisiana. The collection of two recently dead specimens at different localities represents the first since 1911. RP George, SG (reprint author), USA,WATERWAYS EXPT STN ERA,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 7 TC 4 Z9 4 U1 2 U2 5 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 1996 VL 11 IS 2 BP 245 EP 246 DI 10.1080/02705060.1996.9663485 PG 2 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA UH818 UT WOS:A1996UH81800016 ER PT J AU Opal, SM Cross, AS Jhung, JW Young, LD Palardy, JE Parejo, NA Donsky, C AF Opal, SM Cross, AS Jhung, JW Young, LD Palardy, JE Parejo, NA Donsky, C TI Potential hazards of combination immunotherapy in the treatment of experimental septic shock SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MONOCLONAL-ANTIBODY; FACTOR CACHECTIN; SEPSIS; INFECTION; ENDOTOXEMIA; RESISTANCE; MICE; SURVIVAL AB Using an actual infection model of Pseudomonas aeruginosa sepsis in neutropenic rats, the potential utility of a combination anticytokine approach for the treatment of sepsis was tested. A dimeric tumor necrosis factor binding protein (TNF-BP) consisting of two soluble recombinant human TNF type 1 receptors linked with polyethylene glycol was used with recombinant human interleukin-1 receptor antagonist (IL-1ra). Despite having levels of bacteremia and endotoxemia similar to the control group (survivors, 0/18), 30% of IL-1ra-treated animals survived (P <.05); 31% of TNF-BP-treated animals survived (P <.01). Unexpectedly, the combination of IL-1ra plus TNF-BP proved to be uniformly fatal (survivors, 0/20). Endotoxin (P <.0001) and bacteremia (P <.01) levels were >10-fold higher than levels in animals treated with IL-1ra alone, TNF-BP alone, or placebo. Disseminated microabscesses in major organs were found in animals treated with combination immunotherapy. Combination anticytokine therapy may exacerbate systemic infection and worsen outcome in experimental sepsis. C1 MEM HOSP,PROVIDENCE,RI. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP Opal, SM (reprint author), BROWN UNIV,SCH MED,BOX G-PMH,PROVIDENCE,RI 02912, USA. NR 34 TC 42 Z9 45 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1996 VL 173 IS 6 BP 1415 EP 1421 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UM115 UT WOS:A1996UM11500015 PM 8648214 ER PT J AU Schneider, H Schmidt, KA Skillman, DR VandeVerg, L Warren, RL Wylie, HJ Sadoff, JC Deal, CD Cross, AS AF Schneider, H Schmidt, KA Skillman, DR VandeVerg, L Warren, RL Wylie, HJ Sadoff, JC Deal, CD Cross, AS TI Sialylation lessens the infectivity of Neisseria gonorrhoeae MS11mkC SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID 5'-MONOPHOSPHO-N-ACETYL NEURAMINIC ACID; SERUM RESISTANCE; POLYACRYLAMIDE GELS; HUMAN-ERYTHROCYTES; BLOOD-CELLS; LIPOPOLYSACCHARIDE; GONOCOCCI; LIPOOLIGOSACCHARIDE; EXPRESSION; MENINGITIDIS AB In a human challenge experiment, the infectivity of gonococci with sialylated lipooligosaccharide (LOS) was compared with the infectivity of gonococci with unsialylated LOS. Volunteers were intraurethrally inoculated with similar to 5000 sialylated or unsialylated piliated, non-opaque (P(+)Opa(-), transparent) colony type gonococci, strain MS11mkC. Five (83%) of 6 volunteers inoculated with unsialylated gonococci became infected; however, only 1 of 5 volunteers became infected with sialylated gonococci. The unsialylated gonococcal infections, with a median incubation time of 62 h (range, 32-98), were similar to previously described experimental infections, Gonococci shed by infected volunteers showed a transition from the P(+)Opa(-) phenotype of the inoculation strain to the P(+)Opa(+) (piliated, opaque) phenotype 12-60 h before onset of disease. The subject with sialylated gonococcus infection had an extended incubation period, showing a progressive increase in the number of organisms shed until he became symptomatic on day 6 after inoculation. These results show that gonococci with sialylated LOS are less infective than gonococci with unsialylated LOS. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307. NR 31 TC 27 Z9 28 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1996 VL 173 IS 6 BP 1422 EP 1427 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UM115 UT WOS:A1996UM11500016 PM 8648215 ER PT J AU Buma, APCCH vanThiel, PPAM Lobel, HO Ohrt, C vanAmeijden, EJC Veltink, RL Tendeloo, DCH vanGool, T Green, MD Todd, GD Kyle, DE Kager, PA AF Buma, APCCH vanThiel, PPAM Lobel, HO Ohrt, C vanAmeijden, EJC Veltink, RL Tendeloo, DCH vanGool, T Green, MD Todd, GD Kyle, DE Kager, PA TI Long-term malaria chemoprophylaxis with mefloquine in Dutch marines in Cambodia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PROPHYLAXIS; FALCIPARUM; THAILAND AB Three Dutch marine battalions (n = 2289) serving in Western Cambodia during 1992-1993 used mefloquine as weekly malaria chemoprophylaxis. One battalion started with a loading dose. Full compliance with prophylaxis was reported by 86.3%, and possible mefloquine-related adverse events were reported by 30.2%, Sixty-four periods of malaria were diagnosed in 59 marines, During deployment, 31 Plasmodium falciparum and no Plasmodium vivax infections occurred, After return, there were 11 cases of falciparum malaria and 22 of vivax malaria, 16-72 days and 30-540 days, respectively, after stopping prophylaxis. Mefloquine-resistant parasites were isolated from 4 Dutch and 4 Khmer patients. Long-term mefloquine prophylaxis was well tolerated but not totally effective. C1 ACAD MED CTR,DEPT INFECT DIS,AMSTERDAM,NETHERLANDS. ACAD MED CTR,DEPT TROP MED,AMSTERDAM,NETHERLANDS. ACAD MED CTR,DEPT AIDS,AMSTERDAM,NETHERLANDS. ACAD MED CTR,DEPT MED MICROBIOL,AMSTERDAM,NETHERLANDS. MUNICIPAL HLTH SERV,DEPT PUBL HLTH & ENVIRONM,AMSTERDAM,NETHERLANDS. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30341. ARMED FORCES RES INST MED SCI,USA,MED COMPONNENT,BANGKOK 10400,THAILAND. RP Buma, APCCH (reprint author), ROYAL NETHERLANDS NAVY,MED SERV,OCMGD GOKM,NAVAL MED TRAINING,POB 10011,1201 DA HILVERSUM,NETHERLANDS. RI Van Gool, Tom/H-6750-2012 NR 14 TC 35 Z9 35 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1996 VL 173 IS 6 BP 1506 EP 1509 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UM115 UT WOS:A1996UM11500032 ER PT J AU Brown, AE Vahey, MT Zhou, SYJ Chung, RCY Ruiz, NM Hofheinz, D Lane, JR Mayers, DL Hawkes, CA Malone, JL AF Brown, AE Vahey, MT Zhou, SYJ Chung, RCY Ruiz, NM Hofheinz, D Lane, JR Mayers, DL Hawkes, CA Malone, JL TI Relationship between immune complex-dissociated p24 antigen and human immunodeficiency virus type 1 RNA titers in plasma - Reply SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. SRA TECHNOL, ROCKVILLE, MD USA. HENRY M JACKSON FDN ADV MIL RES, ROCKVILLE, MD USA. NATL NAVAL MED CTR, BETHESDA, MD USA. RP Brown, AE (reprint author), WALTER REED ARMY INST RES, SUITE 201, SUITE 201, 13 TAFT CT, ROCKVILLE, MD 20850 USA. NR 4 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1996 VL 173 IS 6 BP 1523 EP 1524 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UM115 UT WOS:A1996UM11500040 ER PT J AU Lee, TP Zah, CE Bhat, R Young, WC Pathak, B Favire, F Lin, PSD Andreadakis, NC Caneau, C Rahjel, AW Koza, M Gamelin, JK Curtis, L Mahoney, DD Lepore, A AF Lee, TP Zah, CE Bhat, R Young, WC Pathak, B Favire, F Lin, PSD Andreadakis, NC Caneau, C Rahjel, AW Koza, M Gamelin, JK Curtis, L Mahoney, DD Lepore, A TI Multiwavelength DFB laser array transmitters for ONTC reconfigurable optical network testbed SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article ID DBR LASER; TRANSMISSION; AMPLIFIERS; 1.5-MU-M; PROPOSAL AB We discuss the design, fabrication, and performance of experimental multiwavelength laser array transmitters that have been used in the reconfigurable optical network testbed for the Optical Network Technology Consortium (ONTC), The experimental four-node multiwavelength network testbed is SONET/ATM compatible. It has employed multiwavelength DFB laser arrays with 4 nm wavelength spacing for the first time, The testbed has demonstrated that multiwavelength DFB laser arrays are indeed practical and reproducible, For the DFB laser arrays used in such a network the precise wavelength spacing in the array and the absolute wavelength control are the most challenging tasks, We have obtained wavelength accuracy better than +/-0.35 nm for all lasers, with some registered to better than +/-0.2 nm, We have also studied the array yield of our devices and used wavelength redundancy to improve the array yield. Coupling efficiencies between -2.1 to -4.5 dB for each wavelength channel have been obtained, It is, achieved by using specially designed lensed fiber arrays placed on a silicon V-grooved substrate to exactly match the laser spacing, The transmitter consisted of a multichip module containing a DFB laser array, an eight-channel driver array based on GaAs IC's, and associated RF circuitry. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Lee, TP (reprint author), BELLCORE,RED BANK,NJ 07701, USA. NR 31 TC 42 Z9 43 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD JUN PY 1996 VL 14 IS 6 BP 967 EP 976 DI 10.1109/50.511596 PG 10 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA UT346 UT WOS:A1996UT34600005 ER PT J AU Bloemer, MJ Haus, JW AF Bloemer, MJ Haus, JW TI Broadband waveguide polarizers based on the anisotropic optical constants of nanocomposite films SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article ID PHOTONIC BANDS; WAVE-GUIDES; LATTICE AB Thin metal-dielectric nanocomposite films (30 nm thick) deposited on ion-exchanged glass waveguides form high extinction polarizers, The polarizing properties are due to the absorption bands of the surface plasmon modes in the nonspherical, nanometer-size silver particles which are embedded in a glass host, The absorption bands of the surface plasmon modes are strongly dependent on the shape and orientation of the nonspherical particles. We demonstrate wavelength tuning and broadening of the polarization band in the silver nanocomposite film by altering the particle shape distribution. We have fabricated waveguide polarizers with extinction ratios 1x10(-4)/mm over the wavelength range of 800-1100 nm. An unusual feature of the polarizer is that it passes the TM polarization, The optical constants of the nanocomposite film were calculated by Maxwell-Garnett theory. The nanocomposite films have a large birefringence (similar to 0.5) and highly anisotropic extinction coefficients. C1 RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180. RP Bloemer, MJ (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 21 TC 18 Z9 18 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD JUN PY 1996 VL 14 IS 6 BP 1534 EP 1540 DI 10.1109/50.511684 PG 7 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA UT346 UT WOS:A1996UT34600061 ER PT J AU Vig, JR Filler, RL Kim, Y AF Vig, JR Filler, RL Kim, Y TI Uncooled IR imaging array based on quartz microresonators SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article ID DETECTORS; THIN AB A quartz crystal resonator's resonance frequency is sensitive to temperature, This sensitivity has been exploited in the past in thermometers made of single, macroscopic quartz resonators that can accurately detect temperature changes of mu K Using semiconductor microfabrication techniques, it is now possible to fabricate a large number of microresonators from a single quartz wafer. It is shown that combining the small thermal mass and high thermal isolation capability of such microresonators, the steep frequency versus temperature characteristics of resonators made of certain cuts of quartz and the low-noise characteristics of quartz crystal oscillators can result in high-performance infrared (IR) sensors and sensor arrays. In a microresonator sensor, the temperature change produced by the absorption of IR energy results in a frequency change that can be measured with a resolution that corresponds to a change in the resonator's temperature of less than a mu K. Calculation shows that an array of microresonators in the 200 MHz-1 GHz range can be the basis of an uncooled IR imaging system with a noise equivalent temperature difference, NETD, of <0.01 K, The design and fabrication problems to be overcome before such microresonator arrays can be realized are discussed. C1 CECOM, RDEC, C2SID, FT MONMOUTH, NJ 07703 USA. RP Vig, JR (reprint author), USA, RES LAB, MONMOUTH JCT, NJ 07703 USA. OI Vig, John/0000-0002-2378-0113 NR 42 TC 33 Z9 33 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD JUN PY 1996 VL 5 IS 2 BP 131 EP 137 DI 10.1109/84.506201 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA UR132 UT WOS:A1996UR13200007 ER PT J AU Vig, JR Filler, RL Kim, Y AF Vig, JR Filler, RL Kim, Y TI Chemical sensor based on quartz microresonators SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article AB A novel chemical sensor is proposed that consists of an array of quartz microresonators. It is shown that a microresonator can act as a quartz crystal microbalance and as a calorimeter, simultaneously, because quartz resonators can be highly sensitive to both mass and temperature changes, By applying a variety of thin-film adsorbers to the different resonators in an array and observing the pattern of frequency changes due to an unknown that is admitted into the resonator array enclosure, one can detect and identify chemical and biological agents. The total frequency change of an individual resonator will be the sum of the frequency change due to mass loading and the frequency change due to the change in temperature resulting from the heats of adsorptions or reactions. It is shown that the proposed sensor is capable of detecting on the order of 10(-6) monolayer of a material deposited onto the resonators' surfaces. C1 CECOM,RDEC,C2SID,FT MONMOUTH,NJ 07703. RP Vig, JR (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. OI Vig, John/0000-0002-2378-0113 NR 12 TC 17 Z9 17 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD JUN PY 1996 VL 5 IS 2 BP 138 EP 140 DI 10.1109/84.506202 PG 3 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA UR132 UT WOS:A1996UR13200008 ER PT J AU Hall, DP Cipriano, ED AF Hall, DP Cipriano, ED TI Frustrated aggression in psychiatric casualties of operation uphold democracy SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article C1 528TH COMBAT STRESS CTR,FT BRAGG,NC. NR 5 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JUN PY 1996 VL 184 IS 6 BP 377 EP 378 DI 10.1097/00005053-199606000-00009 PG 2 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA UR837 UT WOS:A1996UR83700009 PM 8642389 ER PT J AU Mellen, PF Ownbey, JL Seikan, G Moore, J Swanson, SJ Shaver, TR AF Mellen, PF Ownbey, JL Seikan, G Moore, J Swanson, SJ Shaver, TR TI Lymph node involvement in Fabry's disease SO JOURNAL OF NEUROLOGICAL AND ORTHOPAEDIC MEDICINE AND SURGERY LA English DT Article DE Fabry's disease; renal transplant; lymph nodes; electron microscopy AB Fabry's Disease is an unusual, x-linked ''metabolic storage disease'' in which enzyme deficiency leads to accumulation of the metabolic degradation product Ceramide in Lysosomes. Kidneys, eyes and skin are usually affected. Clinical lymph node involvement is unusual. We describe a case in which inguinal lymph nodes were involved with Fabry's disease following renal transplantation. The use of electron microscopy in the diagnosis is described. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ORGAN TRANSPLANTAT SERV,WASHINGTON,DC 20307. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD NEUROLOGICAL ORTHOPAEDIC SURGEONS PI LAS VEGAS PA 2300 SOUTH RANCHO DR, STE 202, LAS VEGAS, NV 89102 SN 0890-6599 J9 J NEUROL ORTH MED S JI J. Neurol. Orthop. Med. Surg. PD SUM PY 1996 VL 17 IS 1 BP 1 EP 3 PG 3 WC Neurosciences; Orthopedics SC Neurosciences & Neurology; Orthopedics GA WG088 UT WOS:A1996WG08800001 ER PT J AU Mellen, PF Skoog, SJ Edward, EG AF Mellen, PF Skoog, SJ Edward, EG TI Bilateral metastatic renal cell carcinoma in a 3 year old child - Unusual clinical outcome SO JOURNAL OF NEUROLOGICAL AND ORTHOPAEDIC MEDICINE AND SURGERY LA English DT Article DE renal cell carcinoma; pediatrics ID WILMS-TUMOR AB Renal cell carcinoma (RCC) the most common solid renal tumor in adults, is infrequently present in childhood. Only 200 cases of RCC in children have been reported. Bilateral RCC in a very young child is exceeding rare. Likewise, survival with metastatic disease is nearly unprecedented. We report a case of metastatic bilateral RCC in a 3 year old child with stable, unresectable disease over 4 years of follow up. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT UROL SURG,WASHINGTON,DC 20307. NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD NEUROLOGICAL ORTHOPAEDIC SURGEONS PI LAS VEGAS PA 2300 SOUTH RANCHO DR, STE 202, LAS VEGAS, NV 89102 SN 0890-6599 J9 J NEUROL ORTH MED S JI J. Neurol. Orthop. Med. Surg. PD SUM PY 1996 VL 17 IS 1 BP 58 EP 60 PG 3 WC Neurosciences; Orthopedics SC Neurosciences & Neurology; Orthopedics GA WG088 UT WOS:A1996WG08800014 ER PT J AU Fisher, JG AF Fisher, JG TI To the editor SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Letter RP Fisher, JG (reprint author), USA,DENT ACT,116 MARKET ST,DANVILLE,PA 17821, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1996 VL 75 IS 6 BP 686 EP 686 DI 10.1016/S0022-3913(96)90262-0 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UP213 UT WOS:A1996UP21300024 ER PT J AU Klicka, MV King, N Lavin, PT Askew, EW Lieberman, HR AF Klicka, MV King, N Lavin, PT Askew, EW Lieberman, HR TI Assessment of dietary intakes of cadets at the US Military Academy at West Point SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article DE nutritional assessment; West Point cadets; dietary intakes; nutritional supplements; military personnel ID NUTRITIONAL ELEMENTS; COLLEGE-STUDENTS; CALCIUM AB Objective: A study was conducted at the US Military Academy, West Point, NY, to assess the nutritional adequacy of menus and dietary intakes of the cadets and to determine the effect of the optional weekday evening meal policy on nutrient intakes. Methods: Dietary intakes were obtained over a 7-day period using a diary-interview technique. Volunteer cadets, 118 males and 86 females, recorded their own intakes and were interviewed by dietitians to verify food records. Cadets were categorized by gender and divided into three groups based on whether they consumed 0-1, 2-3, or 4-5 weekday evening meals in the Cadet Mess. Results: Multivariate methods were used to assess compliance with Military Recommended Dietary Allowances (MRDA) and nutrient densities as well as the role of gender, number of weekday evening meals consumed in the West Point Cadet Mess, and the use of nutritional supplements during the study week. The number of weekday evening meals consumed in the Cadet Mess, was positively correlated with the nutrient intakes of the cadet groups. The female 0-1 group had the highest proportion of individuals with mean intakes providing < 70% MRDA for vitamin B-6, folate, vitamin A, magnesium, or zinc. Snacks provided from 24% to 32% of the energy intakes of the female groups and were often substituted for meals, particularly by cadets who ate the fewest meals in the Cadet Mess. Conclusions: Diet counseling is recommended to help these cadets choose more nutritious meals and snacks. University and college students that choose not to purchase some of their meals from campus dining facilities could have similar dietary intake patterns and nutritional shortcomings. C1 USA,ENVIRONM MED RES INST,MIL NUTR DIV,MCMR,UE,OPN,NATICK,MA 01760. GEOCENTERS INC,NEWTON UPPER FALLS,MA. NEWTON CTR,NEWTON UPPER FALLS,MA. BOSTON BIOSTAT RES FDN INC,NEWTON UPPER FALLS,MA. NR 34 TC 7 Z9 9 U1 0 U2 4 PU AMER COLL NUTRITION PI NEW YORK PA C/O HOSP. JOINT DIS. 301 E. 17TH ST., NEW YORK, NY 10003 SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD JUN PY 1996 VL 15 IS 3 BP 273 EP 282 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA UN099 UT WOS:A1996UN09900011 PM 8935443 ER PT J AU Hodges, PAM Lyon, JMG AF Hodges, PAM Lyon, JMG TI Perspectives on history: Army dietetics in southwest Asia during Operation Desert Shield Desert Storm SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article AB The Army dietitians deployed during Operation Desert Shield and Operation Desert Storm exemplified the commitment, dedication, patriotism, and professionalism of their predecessors. Although some were continuously on the move and all dealt with the extremes of a desert environment, were frequently handicapped with equipment shortages, and coped constantly with the monotony of limited ration variety, throughout their experiences these professionals expressed pride in participating in this national undertaking. The purposes of this article are to familiarize members of The American Dietetic Association with the responses of their colleagues in the US military to another of their nation's calls, to relate some aspects of Army dietetics experienced in Southwest Asia, and to identify the lessons learned in that engagement. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP Hodges, PAM (reprint author), UNIV ALABAMA,DEPT HUMAN NUTR & HOSPITAL MANAGEMENT,BOX 870158,TUSCALOOSA,AL 35487, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU AMER DIETETIC ASSN PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD JUN PY 1996 VL 96 IS 6 BP 595 EP 597 PG 3 WC Nutrition & Dietetics SC Nutrition & Dietetics GA VF443 UT WOS:A1996VF44300022 PM 8655908 ER PT J AU Walker, TW Robert, LL Copeland, RA Githeko, AK Wirtz, RA Githure, JI Klein, TA AF Walker, TW Robert, LL Copeland, RA Githeko, AK Wirtz, RA Githure, JI Klein, TA TI Field evaluation of arthropod repellents, deet and a piperidine compound, AI3-37220, against Anopheles funestus and Anopheles arabiensis in western Kenya SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CULICIDAE; DIPTERA AB A field evaluation of the repellents N,N-diethyl-3-methylbenzamide (deer) and 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220, a piperidine compound) was conducted against Anopheles funestus and An. arabiensis in Kenya. Both repellents provided significantly more protection (P < 0.001) than the ethanol control. AI3-37220 was significantly more effective (P < 0.001) than deet in repelling both species of mosquitoes. After 9 h, 0.1 mg/cm(2) of AI3-37220 provided 89.8% and 71.1% protection against All. arabiensis and An. funestus, respectively. Deer provided >80% protection for only 3 h, and protection rapidly decreased after this rime to 60.2% and 35.1% for An. arabiensis and An. funestus, respectively, after 9 h. Anopheles funestus was significantly less sensitive (P < 0.001) to both repellents than An. arabiensis. The results of this study indicate chat AI3-37220 is more effective than deet in repelling anopheline mosquitoes in western Kenya. C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. USA,MED RES UNIT KENYA,APO,AE 09831. KENYA GOVT MED RES CTR,VECTOR BIOL & CONTROL RES CTR,KISUMU,KENYA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. KENYA GOVT MED RES CTR,BIOMED SCI RES CTR,NAIROBI,KENYA. RP Walker, TW (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,DIV SUPPORT ACT W,AURORA,CO 80045, USA. NR 8 TC 47 Z9 52 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1996 VL 12 IS 2 BP 172 EP 176 PN 1 PG 5 WC Entomology SC Entomology GA UX547 UT WOS:A1996UX54700011 PM 8827589 ER PT J AU Frances, SP Eamsila, C Pilakasiri, C Linthicum, KJ AF Frances, SP Eamsila, C Pilakasiri, C Linthicum, KJ TI Effectiveness of repellent formulations containing deet against mosquitoes in northeastern Thailand SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB Formulations of the repellent diethyl methyl benzamide (deet) were evaluated against mosquitoes in field tests conducted in Sisaket Province, northeastern Thailand. Thirty-three percent deer in an applicator stick provided greater than or equal to 87.1% protection against primarily Culex vishnui, Cx. gelidus, and Cx. tritaeniorhynchus for up to 5 h, and 50% deer in ethanol provided greater than or equal to 93.3% protection against Anopheles sp. and culicines for up to 8 h. The U.S. Army Extended Duration Repellent Formulation ([EDRF], containing 33% deet), 50% deet in ethanol, and 75% deet in ethanol provided complete protection for up to 6 h against primarily Culex vishnui and Anopheles dirus. C1 ARMED FORCES RES INST MED SCI,ROYAL THAI COMPONENT,DIV RES,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,BANGKOK 10400,THAILAND. NR 9 TC 17 Z9 18 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1996 VL 12 IS 2 BP 331 EP 333 PN 1 PG 3 WC Entomology SC Entomology GA UX547 UT WOS:A1996UX54700038 PM 8827616 ER PT J AU Rafferty, JE Biltoft, CA Bowers, JF AF Rafferty, JE Biltoft, CA Bowers, JF TI Overview of meteorological measurements for aerial spray modeling SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article; Proceedings Paper CT Symposium on Aerosol Cloud Dynamics, at the 61st Annual Meeting of the American-Mosquito-Control-Association CY MAR 22, 1995 CL PORTLAND, OR SP Amer Mosquito Control Assoc AB The routine meteorological observations made by the National Weather Service have a spatial resolution on the order of 1,000 km, whereas the resolution needed to conduct or model aerial spray applications is on the order of 1-10 km. Routinely available observations also do not include the detailed information on the turbulence and thermal structure of the boundary layer that is needed to predict the transport, dispersion, and deposition of aerial spray releases. This paper provides an overview of the information needed to develop the meteorological inputs for an aerial spray model such as the FSCBG and discusses the different types of instruments that are available to make the necessary measurements. RP Rafferty, JE (reprint author), USA,W DESERT TEST CTR,METEOROL DIV,DUGWAY PROVING GROUND,DUNGWAY,UT 84022, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1996 VL 12 IS 2 BP 364 EP 367 PN 2 PG 4 WC Entomology SC Entomology GA UX548 UT WOS:A1996UX54800005 PM 8827621 ER PT J AU Andreas, EL AF Andreas, EL TI The temperature of evaporating sea spray droplets - Reply SO JOURNAL OF THE ATMOSPHERIC SCIENCES LA English DT Article RP Andreas, EL (reprint author), USA,COLD REG RES & ENGN LAB,SNOW & ICE DIV,72 LYME RD,HANOVER,NH 03755, USA. NR 8 TC 9 Z9 9 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0022-4928 J9 J ATMOS SCI JI J. Atmos. Sci. PD JUN 1 PY 1996 VL 53 IS 11 BP 1642 EP 1645 DI 10.1175/1520-0469(1996)053<1642:R>2.0.CO;2 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA UP721 UT WOS:A1996UP72100010 ER PT J AU Cohoon, DK Sindoni, OI AF Cohoon, DK Sindoni, OI TI Recovery of the properties of layered magnetic materials using obliquely incident radiation SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article AB We give a treatment of plane waves of arbitrary polarization and angle of incidence impinging on penetrable material. whose regions of constant electromagnetic properties are separated by parallel places. We show how to recover the thickness of the layers and their electromagnetic properties from the scattered radiation. Extremely simple formulas are given for recovering layer properties and for determinants and inverses of 4 by 4 matrices relating representations of electromagnetic fields in adjacent layers. This recovery, while impossible with normally incident radiation, is possible when one uses a continuum of incident radiation angles. We give a means of recovering dielectric and magnetic properties of a penetrable layered material nondestructively by using scattered electromagnetic radiation. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP Cohoon, DK (reprint author), NATL ACAD SCI,2101 CONSTITUT AVE NW,WASHINGTON,DC 20418, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD JUN PY 1996 VL 13 IS 6 BP 1258 EP 1276 DI 10.1364/JOSAA.13.001258 PG 19 WC Optics SC Optics GA UM589 UT WOS:A1996UM58900014 ER PT J AU McLeod, DG AF McLeod, DG TI Some aspects of prostate cancer SO JOURNAL OF UROLOGY LA English DT Editorial Material ID SERUM RP McLeod, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1996 VL 155 IS 6 BP 1987 EP 1988 DI 10.1016/S0022-5347(01)66070-1 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA UK159 UT WOS:A1996UK15900049 PM 8618304 ER PT J AU Morgan, TO Schenkman, NS Peppas, DS RuedaPedraza, EM Shriver, CD Costabile, RA AF Morgan, TO Schenkman, NS Peppas, DS RuedaPedraza, EM Shriver, CD Costabile, RA TI Pelvic clear cell adenocarcinoma in a 14-year-old boy SO JOURNAL OF UROLOGY LA English DT Article DE bladder; prostate; adenocarcinoma ID URETHRA AB Clear cell adenocarcinoma is a descriptive term assigned to rare tumors of the urogenital tract of unknown histogenesis. Based on anatomical location and microscopic similarities to renal cell carcinoma a mesonephric origin has been supported.(1) To our knowledge clear cell adenocarcinoma unassociated with the urothelium arising in the pelvis of a male adolescent has not been reported previously. Morphological evaluation, including immunological staining, and electron and light microscopy, demonstrated characteristics similar to those of mesonephric adenocarcinoma despite an inability to determine the organ of origin. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,UROL & GEN SURG SERV,WASHINGTON,DC 20307. RP Morgan, TO (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL & GEN SURG SERV,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1996 VL 155 IS 6 BP 2062 EP 2063 DI 10.1016/S0022-5347(01)66110-X PG 2 WC Urology & Nephrology SC Urology & Nephrology GA UK159 UT WOS:A1996UK15900090 PM 8618337 ER PT J AU Solberg, VB Olson, JG Boobar, LR Burge, JR Lawyer, PG AF Solberg, VB Olson, JG Boobar, LR Burge, JR Lawyer, PG TI Prevalence of Ehrlichia chaffeensis, spotted fever group Rickettsia, and Borrelia spp infections in ticks and rodents at Fort Bragg, North Carolina SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Ehrlichia; spotted fever group rickettsia; Borrelia; Ixodes scapularis; Dermacentor variabilis; Amblyomma americanum; Sigmodon hispidus ID BORNE INFECTIONS; BURGDORFERI; ANTIBODY; IXODIDAE; CLUSTER; ACARI AB The prevalence of Ehrlichia chaffeensis, spotted fever group rickettsia, and Borrelia spp. was determined in ticks that had been collected using two methods at Fort Bragg, North Carolina. Of 159 tick midgut samples examined using direct fluorescent assays, 3% were positive for spotted fever group Rickettsiae and 5% for Borrelia spp. Sera from 1 Peromyscus leucopus (Gloger), 3 Mus musculus (L.), and 25 Sigmodon hispidus (Say and Ord) were negative for antibodies to Ehrlichia chaffeensis. Dry ice-baited tick traps caught significantly more Ixodes scapular's (Say), Amblyomma americanum (L.), and Dermacentor variabilis (Packard) (total of 158 ticks) compared to collections from rodent hosts (total of one tick). C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BIOMETR,WASHINGTON,DC 20307. CTR DIS CONTROL & PREVENT,ATLANTA,GA 30333. UNIV MAINE,DEPT ENTOMOL,ORONO,ME 04469. RP Solberg, VB (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 9 TC 4 Z9 4 U1 0 U2 10 PU SOC VECTOR ECOLOGY PI SANTA ANA PA PO BOX 87, SANTA ANA, CA 92702 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 1996 VL 21 IS 1 BP 81 EP 84 PG 4 WC Entomology SC Entomology GA UT938 UT WOS:A1996UT93800013 ER PT J AU McCutchan, FE Artenstein, AW SandersBuell, E Salminen, MO Carr, JK Mascola, JR Yu, XF Nelson, KE Khamboonruang, C Schmitt, D Kieny, MP McNeil, JG Burke, DS AF McCutchan, FE Artenstein, AW SandersBuell, E Salminen, MO Carr, JK Mascola, JR Yu, XF Nelson, KE Khamboonruang, C Schmitt, D Kieny, MP McNeil, JG Burke, DS TI Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E from Asia and Africa SO JOURNAL OF VIROLOGY LA English DT Article ID PRIMARY INFECTION; CD4 BINDING; HIV-1; GP120; SEQUENCES; THAILAND; IDENTIFICATION; RETROVIRUS; ANTIBODIES; PATIENT AB Human immunodeficiency virus type 1 isolates of clade E, known to be largely responsible for the fulminating epidemic in Southeast Asia, have been derived exclusively from Asia and Africa. Here,ve provide full or partial sequences of the envelope glycoprotein gene from 13 additional clade E isolates from Asia representing patients in both early and late stages of disease. More extensive comparison of isolates within clade E by geographic locale, stage of disease, and year of isolation is now possible. The genetic diversity of clade E isolates from Asia, particularly among those derived from early-stage patients, is restricted compared with African isolates (mean interisolate distances in gp120, 5.4 and 20.2%, respectively). However, patients hospitalized with AIDS-related illnesses in Thailand harbored clade E isolates exhibiting broader interisolate diversity and with highly heterogeneous third hypervariable loop sequences. An additional pair of cysteine residues, predicting a novel disulfide bridge and present in 80% of clade E isolates from Asia, was uniformly absent from six African isolates. Clade E isolates in Thailand from early-stage subjects continue to be genetically similar to potential vaccine prototype strains, providing a favorable environment for the evaluation of genotype E candidate vaccines. However, evidence of increasing interisolate diversity is appearing among late-stage patients in Asia. This diversification of the clade E virus, if sustained, may impact preventive vaccine development strategies. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD. CHIANG MAI UNIV,CHIANG MAI 50000,THAILAND. TRANSGENE SA,STRASBOURG,FRANCE. RP McCutchan, FE (reprint author), HENRY M JACKSON FDN,RES LAB,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. RI Salminen, Mika/D-8784-2013; OI Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 NR 44 TC 58 Z9 66 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 1996 VL 70 IS 6 BP 3331 EP 3338 PG 8 WC Virology SC Virology GA UL104 UT WOS:A1996UL10400001 PM 8648662 ER PT J AU Burgess, EB AF Burgess, EB TI Defiance county - Brandon,J SO LIBRARY JOURNAL LA English DT Book Review RP Burgess, EB (reprint author), US COMBINED ARMS RES LIB,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 1 PY 1996 VL 121 IS 10 BP 146 EP 146 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA UP802 UT WOS:A1996UP80200184 ER PT J AU Thompson, SW Colvin, DJ Krauss, G AF Thompson, SW Colvin, DJ Krauss, G TI Austenite decomposition during continuous cooling of an HSLA-80 plate steel SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT Symposium on Atomistic Mechanisms of Nucleation and Growth in Solids, at TMS/ASM Materials Week CY OCT 03-05, 1994 CL ROSEMONT, IL SP TMS, ASM ID LOW-ALLOY STEEL; HIGH-STRENGTH; LOW-CARBON; MICROSTRUCTURE; TOUGHNESS AB Decomposition of fine-grained austenite (10-mu m grain size) during continuous cooling of an HSLA-80 plate steel (containing 0.05C, 0.50Mn, 1.12Cu, 0.88Ni, 0.71Cr, and 0.20Mo) was evaluated by dilatometric measurements, light microscopy, scanning electron microscopy, transmission electron microscopy, and microhardness testing. Between 750 degrees C and 600 degrees C, austenite transforms primarily to polygonal ferrite over a wide range of cooling rates, and Widmanstatten ferrite sideplates frequently evolve from these crystals. Carbon-enriched islands of austenite transform to a complex mixture of granular ferrite, acicular ferrite, and martensite (all with some degree of retained austenite) at cooling rates greater than approximately 5 degrees C/s. Granular and acicular ferrite form at temperatures slightly below those at which polygonal and Widmanstatten ferrite form. At cooling rates less than approximately 5 degrees C/s, regions of carbon-enriched austenite transform to a complex mixture of upper bainite, lower bainite, and martensite (plus retained austenite) at temperatures which are over 100 degrees C lower than those at which polygonal and Widmanstatten ferrite form. Interphase precipitates of copper form only in association with polygonal and Widmanstatten ferrite. Kinetic and microstructural differences between Widmanstatten ferrite, acicular ferrite, and bainite (both upper and lower) suggest different origins and/or mechanisms of formation for these morphologically similar austenite transformation products. C1 US MIL ACAD,DEPT CIVIL & MECH ENGN,W POINT,NY 10996. RP Thompson, SW (reprint author), COLORADO SCH MINES,DEPT MET & MAT ENGN,ADV STEEL PROC & PROD RES CTR,GOLDEN,CO 80401, USA. NR 39 TC 78 Z9 97 U1 2 U2 16 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JUN PY 1996 VL 27 IS 6 BP 1557 EP 1571 DI 10.1007/BF02649815 PG 15 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA UR669 UT WOS:A1996UR66900015 ER PT J AU Vaughan, MK Chen, LD Sewerynek, E Herbert, DC Weaker, FJ Vaughan, GM Reiter, RJ AF Vaughan, MK Chen, LD Sewerynek, E Herbert, DC Weaker, FJ Vaughan, GM Reiter, RJ TI Mg2+-dependent and Ca2+, Mg2+-dependent ATPase activities in the harderian gland of rodents: Age and sex influences SO MICROSCOPY RESEARCH AND TECHNIQUE LA English DT Article DE calcium; harderian gland; ATPase ID MALE GOLDEN-HAMSTER; ANDROGEN RECEPTOR; PLASMA-MEMBRANE; BINDING; STIMULATION; TRANSPORT; MYOCYTES AB Three experiments employing male and female Syrian hamsters (aged 1, 2, and 8-10 months), male Sprague-Dawley rats (aged 1, 2, and 10 months) and male C57B1 mice (aged 2, 7, 13, and 29 months) examined the effects of age and sex on Mg2+-dependent and Ca2+ Mg2+-dependent ATPase activity in the Harderian gland. Significant differences due to age and sex were observed in the hamsters and rats but not with age in mice. Generally, male hamsters had significantly higher Mg2+-dependent and Ca2+, Mg2+-dependent (exception at one timepoint) ATPase activity than did females. Age-matched male and female rats had similar values of Mg2+ dependent ATPase activity, but males had significantly higher Ca2+, Mg2+-dependent ATPase activity than females at 2 months of age. (C) 1996 Wiley-Liss, Inc. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. RP Vaughan, MK (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284, USA. NR 28 TC 2 Z9 2 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1059-910X J9 MICROSC RES TECHNIQ JI Microsc. Res. Tech. PD JUN 1 PY 1996 VL 34 IS 2 BP 144 EP 148 DI 10.1002/(SICI)1097-0029(19960601)34:2<144::AID-JEMT8>3.0.CO;2-S PG 5 WC Anatomy & Morphology; Biology; Microscopy SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics; Microscopy GA UH160 UT WOS:A1996UH16000008 PM 8722709 ER PT J AU Newton, MA AF Newton, MA TI Continuum crimes: Military jurisdiction over foreign nationals who commit international crimes SO MILITARY LAW REVIEW LA English DT Review ID HUMAN-RIGHTS; HUMANITARIAN; LAW; INTERVENTION; LESSONS; COURT C1 USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA. NR 158 TC 9 Z9 9 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1996 VL 153 BP 1 EP 93 PG 93 WC Law SC Government & Law GA WN229 UT WOS:A1996WN22900001 ER PT J AU Smith, ME AF Smith, ME TI Major General Wilton Burton Persons, Jr, United States Army (retired) The Judge Advocate General of the Army (1975-1979) SO MILITARY LAW REVIEW LA English DT Article C1 USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC. NR 14 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1996 VL 153 BP 177 EP 243 PG 67 WC Law SC Government & Law GA WN229 UT WOS:A1996WN22900003 ER PT J AU Rosen, LN Martin, L AF Rosen, LN Martin, L TI The measurement of childhood trauma among male and female soldiers in the US Army SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PHYSICAL ABUSE; SEXUAL ABUSE; VETERANS; WOMEN AB One thousand three hundred sixty-five soldiers from the U.S. Army completed a 30-item version of the Childhood Trauma Questionnaire (CTQ) together with four questions on sexual abuse developed for a national survey of U,S, adults, A four-factor solution to the CTQ produced four subscales that were similar to those found in the original study, namely (1) emotional neglect, (2) physical and emotional abuse, (3) sexual abuse, and (4) physical neglect. We found that half of female soldiers reported a childhood history of sexual abuse, compared with one-sixth of male soldiers. Half of both male and female soldiers reported a childhood history of physical abuse, Combined abuse histories were noted in 34% of female and 11% of male soldiers. Abused soldiers reported more psychological symptoms on the Brief Symptom Inventory than nonabused soldiers, The CTQ and screening questions are discussed as possible tools for eliciting histories of abuse from soldiers. RP Rosen, LN (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,MCMR UWI-A,WASHINGTON,DC 20307, USA. NR 12 TC 47 Z9 47 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1996 VL 161 IS 6 BP 342 EP 345 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UP825 UT WOS:A1996UP82500013 PM 8700329 ER PT J AU Brown, AE Burke, DS AF Brown, AE Burke, DS TI Unpublished findings not intended for reference - Response SO MILITARY MEDICINE LA English DT Letter RP Brown, AE (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1996 VL 161 IS 6 BP A5 EP A5 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA UP825 UT WOS:A1996UP82500006 ER PT J AU Knuth, T AF Knuth, T TI Peacetime trauma experience - Response SO MILITARY MEDICINE LA English DT Letter RP Knuth, T (reprint author), EISENHOWER ARMY MED CTR,FT GORDON,GA 30905, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1996 VL 161 IS 6 BP A4 EP A4 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA UP825 UT WOS:A1996UP82500004 ER PT J AU Hammerschmidt, S Muller, A Sillmann, H Muhlenhoff, M Borrow, R Fox, A vanPutten, J Zollinger, WD GerardySchahn, R Frosch, M AF Hammerschmidt, S Muller, A Sillmann, H Muhlenhoff, M Borrow, R Fox, A vanPutten, J Zollinger, WD GerardySchahn, R Frosch, M TI Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): Correlation with bacterial invasion and the outbreak of meningococcal disease SO MOLECULAR MICROBIOLOGY LA English DT Article ID POLYSIALIC ACID CAPSULE; ESCHERICHIA-COLI K1; FRAMESHIFT MUTATION; ENDOTHELIAL-CELLS; EPITHELIAL-CELLS; DNA-SEQUENCE; GONORRHOEAE; EXPRESSION; POLYSACCHARIDE; PROTEIN AB A mechanism of capsular polysaccharide phase variation in Neisseria meningitidis is described. Meningococcal cells of an encapsulated serogroup B strain were used in invasion assays. Only unencapsulated variants were found to enter epithelial cells, Analysis of one group of capsule-deficient variants indicated that the capsular polysaccharide was re-expressed at a frequency of 10(-3). Measurement of enzymatic activities involved in the biosynthesis of the alpha-2,8 polysialic acid capsule showed that polysialyltransferase (PST) activity was absent in these capsule-negative variants. Nucleotide sequence analysis of siaD revealed an insertion or a deletion of one cytidine residue within a run of (dC)(7). residues at position 89, resulting in a frameshift and premature termination of translation. We analysed unencapsulated isolates from carriers and encapsulated case isolates collected during an outbreak of meningococcal disease. Further paired blood-culture isolates and unencapsulated nasopharyngeal isolates from patients with meningococcal meningitis were examined. In all unencapsulated strains analysed we found an insertion or deletion within the oligo-(dC) stretch within siaD, resulting in a frameshift and loss of capsule formation. All encapsulated isolates, however, had seven dC residues at this position, indicating a correlation between capsule phase variation and bacterial invasion and the outbreak of meningococcal disease. C1 HANNOVER MED SCH,INST MED MIKROBIOL,D-30623 HANNOVER,GERMANY. WITHINGTON HOSP,PUBL HLTH LAB,MANCHESTER M20 2LR,LANCS,ENGLAND. NIAID,ROCKY MT LABS,NIH,HAMILTON,MT 59840. MAX PLANCK INST BIOL,D-72076 TUBINGEN,GERMANY. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RI Frosch, Matthias/H-2411-2013; OI van Putten, Jos/0000-0002-4126-8172 NR 52 TC 164 Z9 169 U1 1 U2 8 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD JUN PY 1996 VL 20 IS 6 BP 1211 EP 1220 DI 10.1111/j.1365-2958.1996.tb02641.x PG 10 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA UU880 UT WOS:A1996UU88000010 PM 8809773 ER PT J AU Jackson, MR AF Jackson, MR TI Tissue sealants: Current status, future potential SO NATURE MEDICINE LA English DT Editorial Material RP Jackson, MR (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 11 TC 14 Z9 14 U1 0 U2 1 PU NATURE PUBLISHING CO PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 SN 1078-8956 J9 NAT MED JI Nat. Med. PD JUN PY 1996 VL 2 IS 6 BP 637 EP 638 DI 10.1038/nm0696-637 PG 2 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA UN691 UT WOS:A1996UN69100027 PM 8640550 ER PT J AU Salazar, AM Levy, HB Ondra, S Kende, M Scherokman, B Brown, D Mena, H Martin, N Schwab, K Donovan, D Dougherty, D Pulliam, M Ippolito, M Graves, M Brown, H Ommaya, A AF Salazar, AM Levy, HB Ondra, S Kende, M Scherokman, B Brown, D Mena, H Martin, N Schwab, K Donovan, D Dougherty, D Pulliam, M Ippolito, M Graves, M Brown, H Ommaya, A TI Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: An open pilot study SO NEUROSURGERY LA English DT Article DE dsRNA; interferon; malignant glioma; oligoadenylate; poly-ICLC; tumor suppressors ID DOUBLE-STRANDED-RNA; POLY-L-LYSINE; HUMAN-IMMUNODEFICIENCY-VIRUS; PROTEIN-KINASE; 2',5'-OLIGOADENYLATE SYNTHETASE; RADIATION-THERAPY; INTERFERON-ALPHA; BREAST-CANCER; POLY(I,C)-LC; COMPLEX AB POLYINOSINIC-POLYCYTIDYLIC ACID STABILIZED with polylysine and carboxymethylcellulose (poly-ICLC) (10-50 mcg/kg, administered intramuscularly one to three times weekly) was given for less than or equal to 56 months to 38 patients with malignant gliomas. There was minimal or no toxicity. Twenty of 30 patients (66%) receiving at least twice weekly poly-ICLC showed regression or stabilization of gadolinium-enhancing tumor, as revealed by magnetic resonance imaging (median = 65% volume decrease). All but one patient with anaplastic astrocytomas who received continuous poly-ICLC remain alive, with a median progression-free survival of 54 months from diagnosis. Median Kaplan-Meier survival is 19 months for patients with glioblastomas who receive at least twice weekly poly-ICLC treatments. Tumor response was associated with 2',5'-oligoadenylate synthetase activation (P = 0.03) but not with serum interferon. We hypothesize clinical activation by poly-ICLC of a basic host tumor suppressor system. Prolonged, quality survival with tumor stabilization or regression confirmed by magnetic resonance imaging for most patients with anaplastic astrocytomas and glioblastomas suggests that more extensive laboratory and controlled clinical studies are warranted. The concept of long-term, broad spectrum stimulation of host defenses with nontoxic, inexpensive double-stranded ribonucleic acids, such as low-dose poly-ICLC, may be applicable to the treatment of other malignancies. C1 UNIFORMED SERV UNIV HLTH SCI, WASHINGTON, DC USA. NIAID, WASHINGTON, DC USA. USA, MED RES INST INFECT DIS, WASHINGTON, DC 20310 USA. ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, WASHINGTON, DC USA. RP Salazar, AM (reprint author), WALTER REED ARMY MED CTR, DEF & VET HEAD INJURY PROGRAM, BLDG 7, ROOM 224, WASHINGTON, DC 20307 USA. NR 41 TC 81 Z9 82 U1 2 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD JUN PY 1996 VL 38 IS 6 BP 1096 EP 1103 DI 10.1097/00006123-199606000-00006 PG 8 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA UM763 UT WOS:A1996UM76300012 PM 8727138 ER PT J AU Copeland, AC Trivedi, MM McManamey, JR AF Copeland, AC Trivedi, MM McManamey, JR TI Evaluation of image metrics for target discrimination using psychophysical experiments SO OPTICAL ENGINEERING LA English DT Article DE psychophysical experiments; human target discrimination; target detection; texture perception; clutter metrics ID PERFORMANCE; CLUTTER AB Image clutter affects the perceptual ability of any system for object detection. A procedure for conducting psychophysical experiments has been developed to test computational models for the perceptual similarity or difference of texture patterns, which contributes to image clutter. This experimental procedure is based on Thurstone's law of comparative judgment, which is used along with the method of paired comparisons to assign relative psychological scale values to image stimuli. To facilitate consistency in the presentation of stimuli and collection of data, an X-windows testing environment has been developed called the X-based perceptual experiment testbed. Using this experimental procedure, a pilot study was conducted in which the image stimuli consisted of targets and backgrounds with texture patterns of uncorrelated Gaussian noise. With such patterns, only first-order image statistics are of significance. The psychological scale values relating the level of ''target distinctness'' in each of the image stimuli were compared to several first-order image metrics. Correlation coefficients as high as 0.9881 were found between the scale values and the image metrics. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Copeland, AC (reprint author), UNIV CALIF SAN DIEGO,DEPT ELECT & COMP ENGN,COMP VIS & ROBOT RES LAB,LA JOLLA,CA 92093, USA. NR 20 TC 21 Z9 22 U1 2 U2 4 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 1996 VL 35 IS 6 BP 1714 EP 1722 DI 10.1117/1.600760 PG 9 WC Optics SC Optics GA UR464 UT WOS:A1996UR46400030 ER PT J AU Childers, ELB Ellis, GL Auclair, PL AF Childers, ELB Ellis, GL Auclair, PL TI An immunohistochemical analysis of anti-amylase antibody reactivity in acinic cell adenocarcinoma SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID SALIVARY; GRANULES; GLANDS AB In many salivary acinic cell adenocarcinomas, well-differentiated serous acinar-type cells may be few and inconspicuous. In these cases it may be difficult to distinguish acinic cell adenocarcinoma from other types of salivary gland neoplasms such as cystadenocarcinoma. The usefulness of antisalivary amylase antibody immunohistochemical staining as a diagnostic aid was assessed on paraffin-embedded tissue sections from 27 typical acinic cell adenocarcinomas. Only 4 of 27 tumors showed reactivity in tumor cells. We conclude that anti-amylase antibody is of limited value in the recognition of acinic cell adenocarcinoma when light morphologic features are insufficient for diagnosis. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC. RP Childers, ELB (reprint author), USA DENTAC,FT BRAGG,NC 28307, USA. NR 14 TC 9 Z9 9 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD JUN PY 1996 VL 81 IS 6 BP 691 EP 694 DI 10.1016/S1079-2104(96)80075-8 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UT722 UT WOS:A1996UT72200013 PM 8784901 ER PT J AU Bass, JW Wittler, RR Weisse, ME AF Bass, JW Wittler, RR Weisse, ME TI Social smile and occult bacteremia SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE social smile; occult bacteremia C1 UNIV KANSAS,SCH MED,DEPT PEDIAT,WICHITA,KS 67214. W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT PEDIAT,MORGANTOWN,WV 26506. RP Bass, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUN PY 1996 VL 15 IS 6 BP 541 EP 541 DI 10.1097/00006454-199606000-00013 PG 1 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA UR267 UT WOS:A1996UR26700012 PM 8783353 ER PT J AU Bass, JW AF Bass, JW TI A review of the rationale and advantages of various mixtures of benzathine penicillin G SO PEDIATRICS LA English DT Article; Proceedings Paper CT Conference on Group-A Streptococcal Infections CY JAN 20-22, 1995 CL TAMPA, FL SP Wyeth Ayerst Labs, St Davids AB Intramuscular benzathine (BZ) penicillin G has been accepted as the gold standard for treatment of patients with streptococcal pharyngitis since it was first introduced in 1952. Unfortunately, it has been associated with pain and tenderness at the site of injection. Efforts to lessen this by combining it with varied quantities of procaine (PC) penicillin G have been successful, decreasing the incidence of significant local reactions to 5% to 10%, little more than that seen with PC penicillin alone. A preparation containing 600 000 U BZ penicillin G and 600 000 U PC penicillin in 2 mL has been marketed since the mid-1950s as CR Bicillin 600/600 but the content of BZ penicillin G has been considered adequate only for children who weigh <60 pounds. This prompted the evaluation of a preparation containing 900 000 U BZ penicillin G plus 300 000 U PC penicillin G in a 2-mL injection. Of 400 children with streptococcal pharyngitis 100 each received this preparation, 600 000 U BZ penicillin G alone in 1 mL, 1.2 million U BZ penicillin G alone in 2 mL or 600 000 U BZ penicillin G plus 600 000 U PC penicillin G in 2 mL. Clinical response was equal in all four groups; all patients were well in 36 to 48 hours. The two preparations containing PC penicillin G had significantly less severe local reactions and throat cultures were negative in all by 48 hours; it remained positive in some patients who received BZ penicillin G alone after 72 hours. The cure rate in patients receiving the 900 000/300 000 combination of BZ and PC penicillin G was equal to that in patients who received 1.2 million U BZ penicillin G with these added advantages. This combination offers optimal parenteral treatment for streptococcal pharyngitis in all children who weigh <140 pounds and it has been marketed for this purpose since 1976. RP Bass, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 17 TC 9 Z9 9 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JUN PY 1996 VL 97 IS 6 SU S BP 960 EP 963 PG 4 WC Pediatrics SC Pediatrics GA UQ090 UT WOS:A1996UQ09000005 PM 8637782 ER PT J AU Brundage, JF Gunzenhauser, JD Longfield, JN Rubertone, MV Ludwig, SL Rubin, FA Kaplan, EL AF Brundage, JF Gunzenhauser, JD Longfield, JN Rubertone, MV Ludwig, SL Rubin, FA Kaplan, EL TI Epidemiology and control of acute respiratory diseases with emphasis on Group A beta-hemolytic Streptococcus: A decade of US Army experience SO PEDIATRICS LA English DT Article; Proceedings Paper CT Conference on Group-A Streptococcal Infections CY JAN 20-22, 1995 CL TAMPA, FL SP Wyeth Ayerst Labs, St Davids DE Streptococcus; surveillance; respiratory disease; US Army; benzathine penicillin ID PYOGENES INFECTION; PENICILLIN-G; PROPHYLAXIS; BENZATHINE AB Objective. To summarize the experiences of the U.S. Army regarding prevention and control, and frequencies, rates, trends, and determinants of febrile acute respiratory diseases (ARDs), particularly Group A beta-hemolytic streptococcus (GABHS). Methodology. Since 1966, the U.S. Army has conducted routine surveillance of ARDs among basic trainees. Since 1985, all trainees with fever and respiratory tract symptoms have been cultured for GABHS. Field investigations were conducted when outbreaks of acute respiratory or GABHS-associated illnesses were detected. Mass plus tandem benzathine penicillin prophylaxis were used to interdict and control training center GABHS outbreaks. Results. During the period 1985 to 1994, there were 65 184 hospitalizations for acute febrile respiratory illnesses among Army trainees. The crude hospitalization rate was 0.45 per 100 trainees per week. The rate consistently declined over the period. Incremental declines were temporally associated with increased use of adenovirus immunizations and broader use of benzathine penicillin prophylaxis. During the period, 10 789 of 59 818 (18%) pharyngeal cultures were positive for GABHS. GABHS outbreaks were associated with diverse clinical manifestations including streptococcal toxic shock, acute rheumatic fever, and pneumonia. The emergence of mucoid colony morphology in clinical isolates was a consistent indicator of circulating virulent strains with epidemic potential. Outbreak-associated M types were M1, M3, M5, and M18. In response to six GABHS outbreaks, mass plus tandem benzathine penicillin chemoprophylaxis produced rapid and sustained GABHS control. ARD and GABHS recovery rates were lowest when benzathine penicillin prophylaxis was widely used. Conclusions. ARD rates among Army trainees have consistently declined to unprecedented levels. GABHS has reemerged as an important threat to military trainees. Benzathine penicillin chemoprophylaxis is safe and effective for interdicting and preventing GABHS outbreaks in closed, healthy young adult populations. C1 MADIGAN ARMY MED CTR,PREVENT MED SERV,TACOMA,WA 98431. BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234. US FDA,ROCKVILLE,MD 20857. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,WHO COLLABORATING CTR REFERENCE & RES STREPTOCOCC,MINNEAPOLIS,MN 55455. RP Brundage, JF (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,EPIDEMIOL & DIS SURVEILLANCE DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 16 TC 37 Z9 37 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JUN PY 1996 VL 97 IS 6 SU S BP 964 EP 970 PG 7 WC Pediatrics SC Pediatrics GA UQ090 UT WOS:A1996UQ09000006 PM 8637783 ER PT J AU Wightman, DC AF Wightman, DC TI Our emperors have no clothes - Weiss,A SO PERSONNEL PSYCHOLOGY LA English DT Book Review RP Wightman, DC (reprint author), USA,RES INST BEHAV & SOCIAL SCI,FT RUCKER,AL 36362, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PERSONNEL PSYCHOLOGY INC PI BOWLING GREEN PA 745 HASKINS ROAD, SUITE A, BOWLING GREEN, OH 43402 SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD SUM PY 1996 VL 49 IS 2 BP 478 EP 481 PG 4 WC Psychology, Applied; Management SC Psychology; Business & Economics GA UR027 UT WOS:A1996UR02700012 ER PT J AU Dacre, JC Goldman, M AF Dacre, JC Goldman, M TI Toxicology and pharmacology of the chemical warfare agent sulfur mustard SO PHARMACOLOGICAL REVIEWS LA English DT Review ID ATHYMIC NUDE-MICE; HUMAN-SKIN GRAFTS; ISOLATED HEPATOCYTES; GAS WORKERS; CA-2+ SEQUESTRATION; ALKYLATING-AGENTS; HUMAN-LYMPHOCYTES; BIOLOGICAL FATE; FORMER WORKERS; RAT-LIVER C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 348 TC 203 Z9 213 U1 3 U2 30 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-6997 J9 PHARMACOL REV JI Pharmacol. Rev. PD JUN PY 1996 VL 48 IS 2 BP 289 EP 326 PG 38 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UT107 UT WOS:A1996UT10700005 PM 8804107 ER PT J AU Clauser, JF Dowling, JP AF Clauser, JF Dowling, JP TI Factoring integers with Young's N-slit interferometer SO PHYSICAL REVIEW A LA English DT Article AB We show that a Young's N-slit interferometer can be used to factor the integer N. The device could factor four- or five-digit numbers in a practical fashion. This work shows how number theory may arise in physical problems, and may provide some insight as to how quantum computers can carry out factoring problems by interferometric means. C1 USA, MISSILE COMMAND,CTR RES DEV & ENGN,ST,WS, RD,AMSMI, REDSTONE ARSENAL, AL 35898 USA. RP Clauser, JF (reprint author), UNIV CALIF BERKELEY, DEPT PHYS, BERKELEY, CA 94720 USA. RI DOWLING, JONATHAN/L-2749-2013 NR 4 TC 47 Z9 48 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUN PY 1996 VL 53 IS 6 BP 4587 EP 4590 DI 10.1103/PhysRevA.53.4587 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA UR605 UT WOS:A1996UR60500113 ER PT J AU Rinalducci, EJ Mapes, D CinqMars, SG Higgins, KE AF Rinalducci, EJ Mapes, D CinqMars, SG Higgins, KE TI Determining the field of view in HMDs: A psychophysical method SO PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS LA English DT Article AB Rather than researchers having to rely on manufacturers' specifications or an optical or engineering analysis, this paper provides a psychophysical method for determining the horizontal and vertical field of view of an HMD system. The technique employed makes use of a strobe light induced afterimage of two lights that subtend a predetermined size. This after image can then be used to set the width of two bars in the virtual environment and the number of pixels between the bars can be determined. Simple equations are provided to allow a determination of the basic dimensions of the display. C1 UNIV CENT FLORIDA,INST SIMULAT & TRAINING,ORLANDO,FL 32816. ARMY RES INST,ORLANDO,FL 32816. LIGHTHOUSE INC,NEW YORK,NY. RP Rinalducci, EJ (reprint author), UNIV CENT FLORIDA,DEPT PSYCHOL,ORLANDO,FL 32816, USA. NR 2 TC 6 Z9 6 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD ST JOURNALS DEPT, CAMBRIDGE, MA 02142 SN 1054-7460 J9 PRESENCE-TELEOP VIRT JI Presence-Teleoper. Virtual Env. PD SUM PY 1996 VL 5 IS 3 BP 353 EP 356 PG 4 WC Computer Science, Cybernetics; Computer Science, Software Engineering SC Computer Science GA VF835 UT WOS:A1996VF83500008 ER PT J AU Schumm, WR Bell, DB Rice, RE Schuman, PM AF Schumm, WR Bell, DB Rice, RE Schuman, PM TI Marriage trends in the US Army SO PSYCHOLOGICAL REPORTS LA English DT Article AB Since the early 1950s, the percentage of enlisted personnel who were married at any one time has climbed from approximately 30% of the force to nearly 60% today, while the percentage of married officers has fluctuated between 70 and 90%. Retaining a higher percentage of married enlisted personnel has helped the all volunteer Army reach its strength objectives and has led to the force being older and more experienced than it might otherwise have been. Although evidence is confounded by the correlation of marital status with age, rank, years of service, having children, and gender, it appears that marriage after entering the service is associated with increased retention at least for male soldiers. Marital status has a complex association with combat readiness as both advantages and disadvantages are observed when comparing readiness factors for unmarried and married soldiers. C1 USA,RES INST,ALEXANDRIA,VA 22333. KANSAS STATE UNIV,MANHATTAN,KS 66506. AMERICAN UNIV,WASHINGTON,DC 20016. CATHOLIC UNIV AMER,WASHINGTON,DC 20064. NR 37 TC 7 Z9 7 U1 0 U2 1 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD JUN PY 1996 VL 78 IS 3 BP 771 EP 784 PN 1 PG 14 WC Psychology, Multidisciplinary SC Psychology GA UQ543 UT WOS:A1996UQ54300012 ER PT J AU Schumm, WR Bell, DB Rice, RE Sanders, D AF Schumm, WR Bell, DB Rice, RE Sanders, D TI Trends in dual military couples in the US Army SO PSYCHOLOGICAL REPORTS LA English DT Article AB Dramatic percentage increases in female soldiers, married enlisted soldiers, spouses in the labor force, female single-parent soldiers, and dual military couples have changed the demography of che Army substantially since the end of the Vietnam War and the institution of the All Volunteer Army. The presence of dual-career military families is one change that has shifted the traditional pattern of the unmarried male soldier led by a married male officer. This report documents the changes in dual military families since the early 1970s in the U.S. Army and discusses what effects, if any, there may be on family adaptation, retention, readiness, and use of services and what effects current downsizing initiatives might have on the prevalence of dual military couples in the Army. C1 USA,RES INST BEHAV & SOCIAL SCI,ALEXANDRIA,VA 22333. KANSAS STATE UNIV,MANHATTAN,KS 66506. AMERICAN UNIV,WASHINGTON,DC 20016. NR 41 TC 8 Z9 8 U1 0 U2 1 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD JUN PY 1996 VL 78 IS 3 BP 1287 EP 1298 PN 2 PG 12 WC Psychology, Multidisciplinary SC Psychology GA UV408 UT WOS:A1996UV40800018 ER PT J AU Schumm, WR Bell, DB Rice, RE Perez, MMV AF Schumm, WR Bell, DB Rice, RE Perez, MMV TI Trends in single parenting in the US Army SO PSYCHOLOGICAL REPORTS LA English DT Article AB Dramatic increases in the percentage of female soldiers, married enlisted soldiers, spouses in the labor force, female single-parent soldiers, and dual military couples have changed the demography of the Army substantially since the end of the Vietnam War and the institution of the All Volunteer Army. The presence of single-parent families has perhaps most clearly broken the traditional pattern of the un-married male soldier led by a married male officer. This report documents the increase of single-parent families in the U.S. Army since the early 1970s and discusses what effects, if any, such changes may have had on family adaptation, retention, readiness, and use of family social-support services. C1 USA,RES INST BEHAV & SOCAIL SCI,ALEXANDRIA,VA 22333. KANSAS STATE UNIV,MANHATTAN,KS 66506. AMERICAN UNIV,WASHINGTON,DC 20016. NR 44 TC 4 Z9 4 U1 0 U2 3 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD JUN PY 1996 VL 78 IS 3 BP 1311 EP 1328 PN 2 PG 18 WC Psychology, Multidisciplinary SC Psychology GA UV408 UT WOS:A1996UV40800022 ER PT J AU RAINES, EF AF RAINES, EF TI THE MARINE-CORPS SEARCH FOR A MISSION, 1880-1898 - SHULIMSON,J SO PUBLIC HISTORIAN LA English DT Book Review RP RAINES, EF (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SUM PY 1996 VL 18 IS 3 BP 64 EP 66 PG 3 WC History SC History GA VJ080 UT WOS:A1996VJ08000013 ER PT J AU Tanabe, BK Abe, LM Kimura, LH Reinker, KA Yamaga, KM AF Tanabe, BK Abe, LM Kimura, LH Reinker, KA Yamaga, KM TI Cytokine mRNA repertoire of articular chondrocytes from arthritic patients, infants, and neonatal mice SO RHEUMATOLOGY INTERNATIONAL LA English DT Article DE cytokine mRNAs; articular chondrocytes; rheumatoid arthritis; osteoarthritis; infants; neonatal mice ID NECROSIS-FACTOR-ALPHA; GROWTH-FACTORS; CARTILAGE; INTERLEUKIN-1; EXPRESSION; METABOLISM; MODULATION; INDUCTION; AGAROSE; CELLS AB Articular chondrocytes from nine arthritic patients, five infants, and Balb/c neonatal mice were analyzed for the presence of various cytokine mRNAs by a reverse transcriptase polymerase chain reaction (RT-PCR). Four cytokine mRNAs, interleukin (IL)-6, IL-8, IL-11, and macrophage colony stimulating factor (M-CSF), were detected in all human chondrocytes, regardless of source. IL-10, IL-12p35, and tumor necrosis factor alpha (TNF-alpha) transcripts were found in at least 12 of the 14 human samples. IL-13, granulocyte colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (CM CSF),and TNF-beta mRNAs were found more predominantly in infant samples and in samples from patients with rheumatoid arthritis (RA) compared with samples from patients with osteoarthritis (OA). Another group of cytokine mRNAs, IL-1 (alpha, beta), IL-4, IL-5, and IL-7, were only weakly expressed in some human samples. The cytokine transcripts that were not found were IL-2, IL-3, and interferon gamma (IFN-gamma). Because of the large array of cytokine transcripts detected, human chondrocyte preparations were further purified by reacting them with a monoclonal antibody specific to chondrocyte differentiation antigen and subjecting them to fluorescent-activate cell sorting, A similar array of cytokines was found between the sorted and unsorted chondrocytes, although TNF-alpha, G-CSF and GM-CSF transcripts appeared to be upregulated during the sorting process. Human chondrocytes that dedifferentiated into fibroblasts (a 40-day and a 77-day culture) no longer expressed mRNAs for IL-1, G-CSF, CM-CSF and TNF-alpha, but all other cytokine mRNAs remained detectable. Although certain phenotypic characteristics were lost, including reactivity to chondrocyte-specific monoclonal antibodies and morphological features, chondrocytes in long-term culture still expressed cytokine mRNAs. As expected, more consistent results were obtained when seven preparations of chondrocytes from neonatal Balb/c mice were examined using available cytokine primers. They contained IL-1,IL-5, IL-6, IL-7, IL-12, GM-CSF M-CSF transforming growth factor beta (TGF-beta), TNF-alpha and TNF-beta mRNAs but lacked IL-2, IL-3, IL-4, IL-10, and IFN-gamma mRNAs. Future experiments to define conditions by which these cytokine protein products are expressed are needed to help assess their roles in chondrocyte biology and in disease states. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96819. SHRINERS HOSP CRIPPLED CHILDREN,HONOLULU,HI 96821. RP Tanabe, BK (reprint author), UNIV HAWAII,JOHN A BURNS SCH MED,DEPT TROP MED & MED MICROBIOL,HONOLULU,HI 96816, USA. NR 29 TC 16 Z9 16 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0172-8172 J9 RHEUMATOL INT JI Rheumatol. Int. PD JUN PY 1996 VL 16 IS 2 BP 67 EP 76 DI 10.1007/BF01816438 PG 10 WC Rheumatology SC Rheumatology GA UY997 UT WOS:A1996UY99700005 PM 8853228 ER PT J AU Anderson, DM Nachman, P Estell, RE Ruekgauer, T Havstad, KM Fredrickson, EL Murray, LW AF Anderson, DM Nachman, P Estell, RE Ruekgauer, T Havstad, KM Fredrickson, EL Murray, LW TI The potential of laser-induced fluorescence (LIF) spectra of sheep feces to determine diet botanical composition SO SMALL RUMINANT RESEARCH LA English DT Article DE diets; sheep; fecal samples; laser-induced fluorescence (LIF); botanical composition ID GREEN PLANTS; REFLECTANCE; TERRESTRIAL; HERBIVORES; STRESS AB Laser-induced fluorescence (LIF) peaks near 470 nm ('blue') and 650 nm ('red') from sheep feces treated with chloroform (CHCl3) displayed spectral signatures that varied with diet. Fecal samples were obtained rectally over 3 days in a replicated study consisting of four diets (treatments) fed to 16 Polypay and Polypay x Rambouillet lambs (four lambs per treatment). Basal diet consisted of tobosa (Pleuraphis mutica Buckley [formally Hilaria mutica (Buckl.) Benth,] hay with 0% (control), 10%, 20% or 30% tarbush (Flourensia cernua D.C.) added on a dry matter basis. Feces were dried at 60 degrees C, treated with chloroform and the extract from both crushed and intact fecal material was then excited by laser input at 355 nm. Tarbush leaves gave LIF only in the blue region of the spectrum. However, tobosa hay and all fecal pellets produced a bimodal LIF spectral distribution with a lower, broader peak feature in the blue region and a narrower well defined taller feature in the red region of the spectrum, Chloroform did not exhibit fluorescence peaks between 400 nm and 800 nm, As tarbush in the diet increased, so did the magnitude of counts in the blue region of the spectrum, The LIF red/blue intensity ratios appear to be more reliable than actual counts in differentiating feces of sheep fed tobosa diets containing differing amounts of tarbush. Red/blue ratios decreased (P < 0.05) linearly (P < 0.005) for both crushed and intact sheep fecal pellets as the tarbush/tobosa ratio in the diet increased, Inconsistencies in count amplitudes and wavelengths in either one or both regions (red or blue) of the spectrum and in red/blue ratios (especially on Day 3 for crushed fecal samples) are discussed in terms of sample preparation procedures and sampling days. Our results suggest that further testing of the LIF technique is warranted using diets consisting of several species. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. NEW MEXICO STATE UNIV,DEPT EXPTL STAT,LAS CRUCES,NM 88003. RP Anderson, DM (reprint author), NEW MEXICO STATE UNIV,USDA ARS,JORNADA EXPTL RANGE,DEPT 3JER,BOC 30003,LAS CRUCES,NM 88003, USA. NR 39 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4488 J9 SMALL RUMINANT RES JI Small Ruminant Res. PD JUN 1 PY 1996 VL 21 IS 1 BP 1 EP 10 DI 10.1016/0921-4488(95)00817-9 PG 10 WC Agriculture, Dairy & Animal Science SC Agriculture GA UQ988 UT WOS:A1996UQ98800001 ER PT J AU Jackson, JL AF Jackson, JL TI The Dutch health care system: Lessons for reform in the United States SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID NETHERLANDS; INSURANCE; COMPETITION; VALUES AB The Dutch health care system achieves universal access with high-quality outcomes at a cost below that in the United States. As US policy makers struggle with issues regarding access, quality, and cost, scrutiny of successful systems in other nations may be useful. Review of health care in the Netherlands and contrast with that in the United States offer lessons of potential use in US health care reform. RP Jackson, JL (reprint author), WALTER REED ARMY MED CTR,DEPT INTERNAL MED,6825 16TH ST NW,WASHINGTON,DC 20307, USA. NR 31 TC 4 Z9 4 U1 2 U2 2 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD JUN PY 1996 VL 89 IS 6 BP 567 EP 572 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA UP118 UT WOS:A1996UP11800003 PM 8638194 ER PT J AU Colbeck, SC AF Colbeck, SC TI Capillary bonding of wet surfaces SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE adhesion; capillarity; water film; snow skis; contact angle AB Adhesion of wet surfaces to one another through a water him is common and important for a variety of problems. The nature of this adhesion is explored through a simple model of a grooved polyethylene surface adhering to ice. The effects of contact angle and geometry are included. A set of experiments was performed to show how contact area and adhesive force vary with water tension for glass on porous ceramic. The results show that the model describes the general characteristics of the adhesion but further experiments are necessary for materials of particular interest. RP Colbeck, SC (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 5 TC 6 Z9 6 U1 0 U2 9 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JUN PY 1996 VL 81 IS 2-3 BP 209 EP 214 DI 10.1016/0257-8972(95)02475-1 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA UR497 UT WOS:A1996UR49700011 ER PT J AU Chang, FCT Bauer, RM Benton, BJ Keller, SA Capacio, BR AF Chang, FCT Bauer, RM Benton, BJ Keller, SA Capacio, BR TI 4-aminopyridine antagonizes sanitoxin- and tetrodotoxin-induced cardiorespiratory depression SO TOXICON LA English DT Article ID ANESTHETIZED GUINEA-PIGS; SAXITOXIN; URETHANE; RABBIT; AMINOPYRIDINES; INHIBITION; ANTIBODY; CORTEX; AWAKE; STX AB Antagonism of saxitoxin- and tetrodotoxin-induced lethality by 4-aminopyridine was studied in urethane-anesthetized guinea pigs instrumented for the concurrent recordings of medullary respiratory-related unit activities (Botzinger complex and Nu. para-Ambiguus), diaphragmatic electromyogram, electrocorticogram. Lead II electrocardiogram, blood pressure, end-tidal CO2 and arterial O-2/CO2/pH. The toxin (either saxitoxin or tetrodotoxin) was infused at a dose rate of 0.3 mu g/kg/min (i.v.) to produce a state of progressive cardiorespiratory depression. The animals were artificially ventilated when the magnitude of integrated diaphragm activities was reduced to 50% of control. Immediately after the disappearance of the diaphragm electromyogram, the toxin infusion was terminated, and 4-aminopyridine (2 mg/kg, i.v.) was administered. The therapeutic effect of 4-aminopyridine was striking in that the toxin-induced blockade of diaphragmatic neurotransmission, vascular hypotension, myocardial anomalies, bradycardia and aberrant discharge patterns of medullary respiratory-related neurons could all be promptly restored to a level comparable to that of control condition. The animals were typically able to breathe spontaneously within minutes after 4-aminopyridine. At the dose level used to achieve the desired therapeutic responses, 4-aminopyridine produced no sign of seizure and convulsion. Although less serious side-effects such as cortical excitant/arousal and transient periods of fascicular twitch could be observed, these events were of minor concern, in our opinion, particularly in view of the remarkable therapeutic effects of 4-aminopyridine. Published by Elsevier Science Ltd RP Chang, FCT (reprint author), USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 44 TC 16 Z9 22 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD JUN PY 1996 VL 34 IS 6 BP 671 EP 690 DI 10.1016/0041-0101(95)00167-0 PG 20 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA UW030 UT WOS:A1996UW03000005 PM 8817812 ER PT J AU Thompson, I AF Thompson, I TI Induction androgen deprivation plus prostatectomy for stage T3 disease: Failure to achieve prostate-specific antigen-based freedom from disease status in a phase II trial - Editorial comment SO UROLOGY LA English DT Editorial Material ID CANCER RP Thompson, I (reprint author), BROOKE ARMY MED CTR,DEPT UROL,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD JUN PY 1996 VL 47 IS 6 BP 876 EP 877 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA UT256 UT WOS:A1996UT25600020 ER PT J AU Sherwood, JA Copeland, RS Taylor, KA Abok, K Oloo, AJ Were, JBO Strickland, GT Gordon, DM Ballou, WR Bales, JD Wirtz, RA Wittes, J Gross, M Que, JU Cryz, SJ Oster, CN Roberts, CR Sadoff, JC AF Sherwood, JA Copeland, RS Taylor, KA Abok, K Oloo, AJ Were, JBO Strickland, GT Gordon, DM Ballou, WR Bales, JD Wirtz, RA Wittes, J Gross, M Que, JU Cryz, SJ Oster, CN Roberts, CR Sadoff, JC TI Plasmodium falciparum circumsporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria of Kenya SO VACCINE LA English DT Article DE human malaria; malaria vaccine; Plasmodium falciparum; immunology; entomology ID T-CELL EPITOPE; SPOROZOITES TRANSMITTED INVITRO; NATURALLY ACQUIRED ANTIBODIES; WILD AFROTROPICAL ANOPHELES; IMMUNOSORBENT-ASSAY ELISA; WESTERN KENYA; FIELD-EVALUATION; IMMUNE-RESPONSE; PROTEIN; CULICIDAE AB It has been hypothesized that antibody induced by Plasmodium falciparum circumsporozoite protein vaccine would be effective against endemic human malaria. In a malaria endemic region of Kenya, 76 volunteers, in 38 pairs sleeping adjacently, were immunized with subunit circumsporozoite protein Asn-Ala-Asn-Pro tetrapeptide repeat-pseudomonas toxin A, or hepatitis B vaccine. After quinine and doxcycycline, volunteers were followed for illness daily, parasitemia weekly, antibody, T-lymphocyte responses, and treated if indicated. Anopheles mosquitoes vesting in houses were collected and tested for P. falciparum antigen, or dissected for sporozoites and tested for blood meal ABO type and P. falciparum antigen. Vaccine was safe, with side-effects similar in both groups, and immunogenic, engendering IgG antibody as high as 600 mu g ml(-1), but did not increase the proportion of volunteers with T-lymphocyte responses. Estimation of P. falciparum challenge averaged 0.194 potentially infective Anopheles bites/volunteer/ day. Mosquito blood meals showed no difference in biting intensity between vaccine and control groups Both groups had similar malaria-free survival curves, cumulative positive blood slides, cumulative parasites mm(-3) and numbers of parasites mm(-3) on first positive blood slide, during three post-vaccination observation periods. Every volunteer had P. falciparum parastiemia at least once. Vaccinees had 82% and controls 89% incidences of symptomatic parasitemia (P = 0.514, efficacy 9%, statistical power 95% probability of efficacy < 50%). Vaccine-induced anti-sporozoite antibody was not protective in this study. Within designed statistical precisions the present study is in agreement with efficacy studies in Colombia, Venezuela and Tanzania. C1 SARADIDI RURAL HLTH PROGRAMME,NYILIMA,KENYA. KENYA GOVT MED RES CTR,BIOMED SCI RES CTR,NAIROBI,KENYA. CTR DIS CONTROL,ATLANTA,GA 30333. KENYA GOVT MED RES CTR,VECTOR BIOL & CONTROL RES CTR,KISUMU,KENYA. UNIV MARYLAND,SCH MED,INT HLTH PROGRAM,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. SMITHKLINE BEECHAM,SMITH KLINE & FRENCH LABS,KING OF PRUSSIA,PA. SWISS SERUM & VACCINE INST,CH-3001 BERN,SWITZERLAND. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP Sherwood, JA (reprint author), CLIN RES CTR,NAIROBI,KENYA. NR 63 TC 23 Z9 24 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JUN PY 1996 VL 14 IS 8 BP 817 EP 827 DI 10.1016/0264-410X(95)00221-L PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA UU854 UT WOS:A1996UU85400012 PM 8817830 ER PT J AU Frankenburg, S Axelrod, O Kutner, S Greenblatt, CL Klaus, SN Pirak, EA McMaster, R Lowell, GH AF Frankenburg, S Axelrod, O Kutner, S Greenblatt, CL Klaus, SN Pirak, EA McMaster, R Lowell, GH TI Effective immunization of mice against cutaneous leishmaniasis using an intrinsically adjuvanted synthetic lipopeptide vaccine SO VACCINE LA English DT Article DE Leishmania major; lauryl-cysteine; vaccination ID T-CELL EPITOPES; SURFACE GLYCOPROTEIN GP63; PROPHYLACTIC IMMUNIZATION; PROTECTIVE IMMUNITY; SUBCUTANEOUS IMMUNIZATION; MAJOR INFECTION; MURINE MODEL; INDUCTION; PEPTIDES; PROMASTIGOTES AB Two peptides representing predicted T-cell epitopes of gp63, a major surface glycoprotein of the parasite Leishmania major, were used in vaccines tested in a murine model of cutaneous leishmaniasis. Either subcutaneous or intraperitoneal immunization in saline with a peptide representing gp63 amino acids 467-482 (p467) significantly protected CBA mice against the development of severe cutaneous lesions only when the peptide was intrinsically adjuvanted by covalently adding a lauryl-cysteine moiety (LC-p467) to its amino terminus during synthesis. In marked contrast, administration of p467 alone, cysteinyl-p467 or gp63 protein in saline resulted in some disease exacerbation. Splenic cells of LC-p467 immunized mice stimulated in vitro with LC-p467 displayed strong proliferative responses and secretion of IL-2, IFN-tau and GM-CSF (but not IL-4 and IL-10) suggesting that immunization with the lipopeptide induced the THl type cytokine responses associated with cell-mediated immunity. The safety, efficacy, ease of production and standardization of such lipopeptide vaccines suggest that they have significant potential for the development of vaccines for humans against leishmaniasis or other parasitic or viral diseases that require cell-mediated immunity for protection. Copyright (C) 1996 Elsevier Science Ltd. C1 HEBREW UNIV JERUSALEM,DEPT PARASITOL,JERUSALEM,ISRAEL. WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL. WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC. UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC,CANADA. RP Frankenburg, S (reprint author), HADASSAH MED ORG,DEPT DERMATOL,POB 12000,JERUSALEM,ISRAEL. NR 34 TC 16 Z9 16 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JUN PY 1996 VL 14 IS 9 BP 923 EP 929 DI 10.1016/0264-410X(95)00245-V PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA VA098 UT WOS:A1996VA09800012 PM 8843636 ER PT J AU Barbiero, RP Ashby, SL Kennedy, RH AF Barbiero, RP Ashby, SL Kennedy, RH TI The effects of artificial circulation on a small northeastern impoundment SO WATER RESOURCES BULLETIN LA English DT Article DE artificial circulation; water quality; phosphorus loading; Fe; Mn; dissolved oxygen ID PHYTOPLANKTON AB Artificial circulation was applied at East Sidney Lake, a small, eutrophic impoundment in New York, to improve the water quality of the reservoir and tailwater. Treatment was successful at both reducing the stability of the reservoir and maintaining higher mean oxygen concentrations in the bottom waters. Discharge waters had lower metals and phosphorus concentrations during treatment years. However, vertical temperature differences, although minimal, were still sufficient to permit chemical stratification and some phosphorus release from the sediments. Frequent mixing events during periods of low stability, and runoff from storm events, also appeared to increase transport of phosphorus into the epilimnion. Overall, treatment did not result in decreases in algal populations or improvements in water clarity. C1 USA,ENGINEER WATERWAYS EXPT STN,ES P,VICKSBURG,MS 39180. RP Barbiero, RP (reprint author), ASCI CORP,1720 CLAY ST,VICKSBURG,MS 39180, USA. NR 19 TC 5 Z9 5 U1 0 U2 3 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD JUN PY 1996 VL 32 IS 3 BP 575 EP 584 PG 10 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA UV270 UT WOS:A1996UV27000015 ER PT J AU Wakeley, JS Sprecher, SW Lichvar, RW AF Wakeley, JS Sprecher, SW Lichvar, RW TI Relationships among wetland indicators in Hawaiian rain forest SO WETLANDS LA English DT Article DE rain forest; Hawaii; wetland indicators; hydric soils; Folists; plant communities; hydrophytic vegetation; prevalence value; delineation manuals AB We applied established methods for wetland identification in lowland and montane wet forests (rain forests) on the island of Hawaii to determine whether rain forests exhibited wetland indicators specified in delineation manuals and to examine relationships among indicators of hydrophytic vegetation, hydric soils, and wetland hydrology. Morphological characteristics and ferrous iron tests indicated pockets of hydric organic soils within areas mapped as Folists. Hydrophytic vegetation decisions based on prevalence values agreed with hydric soil determinations more often than did decisions based on dominant plant species. None of the rain forest types we studied exhibited wetland indicators throughout, but some sites contained scattered small wetlands occupying microtopographic lows created by cracks, folds, and undulating flow patterns in the lava bedrock. Further work is needed to identify reliable wetland indicators that can be used during drier portions of the year and to distinguish hydric from nonhydric organic rain forest soils. RP Wakeley, JS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 25 TC 6 Z9 6 U1 1 U2 3 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 1996 VL 16 IS 2 BP 173 EP 184 PG 12 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA UU259 UT WOS:A1996UU25900008 ER PT J AU Bustos, O AF Bustos, O TI More on headphone neuralgia SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP Bustos, O (reprint author), OFF US ARMY SURGEON GEN,FALLS CHURCH,VA 22041, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 30 PY 1996 VL 334 IS 22 BP 1480 EP 1480 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA UM493 UT WOS:A1996UM49300028 PM 8618601 ER PT J AU Ding, XZ Smallridge, RC Galloway, RJ Kiang, JG AF Ding, XZ Smallridge, RC Galloway, RJ Kiang, JG TI Rapid assay of HSF1 and HSF2 gene expression by RT-PCR SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE reverse transcriptase polymerase chain reaction; gene; method; HSF1; HSF2; heat shock proteins; epithelia ID HEAT-SHOCK FACTOR; DNA-BINDING; ACTIVATION; PROTECTS; PROTEINS; SEQUENCE; CLONING; DAMAGE; CELLS; CDNA AB Primers were developed to allow the rapid and reliable assay of heat shock transcriptional factors 1 and 2 in human epidermoid A431 cells by following the protocol described in this study. Using the primers, the heat-induced increase in heat shock transcriptional factor 1 but not 2 was observed. This is the first report to show that heat shock increases the mRNA amount of HSF1 with no changes in HSF2 mRNA. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT CLIN PHYSIOL, DIV MED, WASHINGTON, DC 20307 USA. NR 24 TC 16 Z9 16 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0300-8177 J9 MOL CELL BIOCHEM JI Mol. Cell. Biochem. PD MAY 24 PY 1996 VL 158 IS 2 BP 189 EP 192 PG 4 WC Cell Biology SC Cell Biology GA UV966 UT WOS:A1996UV96600012 PM 8817481 ER PT J AU Donescu, P Virgin, LN Wu, JJ AF Donescu, P Virgin, LN Wu, JJ TI Periodic solutions of an unsymmetric oscillator including a comprehensive study of their stability characteristics SO JOURNAL OF SOUND AND VIBRATION LA English DT Article AB The periodic solutions of a non-linear oscillator with unsymmetric restoring force and harmonic excitation are studied by means of harmonic balance using an arbitrary number of modes in the assumed solution. Comparisons between the approximate solution for two modes are made with respect to both one mode and numerical solutions. Different stability criteria have been used in a comparative analysis which shows that higher order criteria not only give more accurate results but also respect the correct sequence of flips and folds without a significant increase in computational cost. (C) 1996 Academic Press Limited C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Donescu, P (reprint author), DUKE UNIV,DEPT MECH ENGN & MAT SCI,DURHAM,NC 27708, USA. NR 14 TC 7 Z9 7 U1 1 U2 2 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD MAY 23 PY 1996 VL 192 IS 5 BP 959 EP 976 DI 10.1006/jsvi.1996.0228 PG 18 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA UM321 UT WOS:A1996UM32100004 ER PT J AU Xu, J Gross, RA Kaplan, DL Swift, G AF Xu, J Gross, RA Kaplan, DL Swift, G TI Chemoenzymatic route to poly(3-hydroxybutyrate) stereoisomers SO MACROMOLECULES LA English DT Article ID SUBSTITUTED BETA-PROPIOLACTONES; RING-OPENING POLYMERIZATION; ORGANIC-SOLVENTS; QUANTITATIVE-ANALYSES; MONOMERS; BUTYROLACTONE; LACTONIZATION; HYDROXYESTERS; ENANTIOMERS; RESOLUTION AB Racemic butyrolactone (BL) was selected to determine the feasibility of using enzyme catalysis in organic media for beta-substituted beta-propiolactone resolutions. Lipases from Candida cylindracia, Pseudomonas fluorescens (PS-30), and porcine pancreatic lipase Type II (PPL) were investigated. Based on reaction rate and the enantiomeric ratio E, PPL was found to be the most effective of these lipases. With respect to the organic media used, BL methanolysis occurred faster to slower as follows: n-hexane > diethyl ether > dioxane congruent to ethyl acetate > benzene. PPL-catalyzed BL methanolysis in n-hexane and diethyl ether reached similar to 50% conversion in 22 h. Irrespective of the solvent used, the slower reacting enantiomer was (R)-BL. The E values for PPL-catalyzed BL resolutions carried out in diethyl ether, benzene, ethyl acetate, 1,4-dioxane, and hexane were 20.4 +/- 2.4, 14.8 +/- 2.3, 8.94 +/- 1.28, 8.15 +/- 1.04, and 5.56 +/- 0.37, respectively. Thus, using PPL as the lipase in ether, 90%-(R)-BL was obtained in 35% yield. This monomer was polymerized using Zn(C2H5)(2)/H2O (1/0.6) as the catalyst to form predominantly (R)-poly(3-hydroxybutyrate) (P3HB) which had number-average molecular weight, melting point, and enthalpy of melting values of 41 300, 140 degrees C, and 64.6 J/g, respectively. Thus, a chemoenzymatic route to high molecular weight enantiomerically enriched P3HB was demonstrated. C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,STRNC,YM,NATICK,MA 01760. ROHM & HAAS CO,SPRING HOUSE,PA 19477. NR 42 TC 24 Z9 24 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 20 PY 1996 VL 29 IS 11 BP 3857 EP 3861 DI 10.1021/ma951899l PG 5 WC Polymer Science SC Polymer Science GA UM264 UT WOS:A1996UM26400025 ER PT J AU Alkins, SA Byrd, JC Morgan, SK Ward, FT Weiss, RB AF Alkins, SA Byrd, JC Morgan, SK Ward, FT Weiss, RB TI Anaphylactoid reactions to methotrexate SO CANCER LA English DT Article DE methotrexate; immediate hypersensitivity; immediate anaphylaxis; osteosarcoma; pharmacotherapy; adverse effects ID HIGH-DOSE METHOTREXATE; OSTEOGENIC-SARCOMA AB BACKGROUND. Methotrexate is a chemotherapeutic agent frequently utilized for the treatment of malignant, rheumatic, and pulmonary diseases. Although this agent has been extensively used for more than 45 years, there are few reports of immediate systemic hypersensitivity reactions. The reported immediate reactions include anaphylaxis, urticaria, and hepatitis. However, these reactions have been reported to occur only after some prior exposure to methotrexate. No immediate hypersensitivity reactions to methotrexate have been reported during the initial exposure. We describe two patients who developed immediate systemic hypersensitivity reactions during the initial administration of methotrexate. METHODS. The clinical outcomes of two patients treated by the Hematology/Oncology department at a tertiary care military medical center are described. The National Library of Medicine in Bethesda, Maryland, was electronically searched for the literature review. RESULTS. Patient 1, a 30-year-old male with localized high grade osteosarcoma of the left distal femur, developed generalized pruritus, urticaria, angioedema, and pharyngeal edema within 10 minutes of receiving the initial administration of intravenous high-dose methotrexate. No other pharmaceutical agents, such as antiemetics, were found to cause symptoms on rechallenge. The severity of this reaction precluded continuation of methotrexate therapy. Patient 2, a 23-year-old male with localized high grade osteosarcoma of the right distal tibia, developed pruritus and urticaria within 30 minutes of receiving the initial administration of intravenous high dose methotrexate. This patient, like most patients with immediate hypersensitivity reactions to methotrexate, developed recurrent symptoms during rechallenge of this agent despite prophylactic premedication. CONCLUSIONS. Unlike prior reports in our literature, our cases demonstrate that anaphylactoid reactions can occur during the initial exposure to methotrexate. Clinicians must be prepared to treat potentially life-threatening reactions with both the initial and subsequent doses of methotrexate. (C) 1996 American Cancer Society. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Alkins, SA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 13 TC 25 Z9 26 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAY 15 PY 1996 VL 77 IS 10 BP 2123 EP 2126 DI 10.1002/(SICI)1097-0142(19960515)77:10<2123::AID-CNCR24>3.0.CO;2-W PG 4 WC Oncology SC Oncology GA UJ262 UT WOS:A1996UJ26200024 PM 8640680 ER PT J AU Thornton, EB Humiston, RT Birkemeier, W AF Thornton, EB Humiston, RT Birkemeier, W TI Bar/trough generation on a natural beach SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID LONGSHORE-CURRENT; SEDIMENT TRANSPORT; WAVES; MODEL AB Mechanisms for bar/trough generation are examined using velocities measured in the field applied to the Bowen [1980]/Bailard [1981] energetics-based sediment transport model. Measurements consist of a cross-shore array of nine electromagnetic current meters spanning the surf zone and daily bathymetric surveys during a IO-day period during which two storms occurred, when the bathymetry evolved from a three-dimensional terrace to a well-developed linear bar. The model predicts bed and suspended load transport separately based on various velocity moments. The velocities are partitioned into mean currents, low-frequency infragravity and shear instabilities (<0.05 Hz), and high-frequency short waves and turbulence (>0.05 Wt) to determine the relative importance of various mechanisms to the total transport. Velocity moments are computed over 90-min intervals to resolve tidal fluctuations. Tidal signatures were apparent in all modes of transport. Predicted transport rates are integrated and compared with daily cross-shore bathymetric profiles (averaged over a 400-m length of beach). The suspended load terms were an order of magnitude greater than bed load terms owing to the low fall velocity of the fine-grain sand within the surf zone. Model results for this experiment indicate the dominant mechanism for bar development was sediments mobilized by the strong longshore current and incident short waves within the surf zone and transported offshore by the mean undertow and shoreward transport onshore due to short wave velocity skewness. Using standard coefficients, the model correctly predicted the first-order movement of the bar during storms, but underpredicted trough development, and did not always perform well during mild wave conditions. C1 USN, PACIFIC METEOROL & OCEANOG CTR, HONOLULU, HI 96860 USA. USA, CORPS ENGINEERS, FIELD RES FACIL, KITTY HAWKS, NC 27949 USA. RP Thornton, EB (reprint author), USN, POSTGRAD SCH, DEPT OCEANOG, MONTEREY, CA 93943 USA. NR 34 TC 117 Z9 117 U1 1 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAY 15 PY 1996 VL 101 IS C5 BP 12097 EP 12110 DI 10.1029/96JC00209 PG 14 WC Oceanography SC Oceanography GA UL258 UT WOS:A1996UL25800018 ER PT J AU Hickey, TE Blair, PJ Perfetto, S Smoot, DS Wagner, KF StLouis, DC Mayers, DL Siegel, JN June, CH AF Hickey, TE Blair, PJ Perfetto, S Smoot, DS Wagner, KF StLouis, DC Mayers, DL Siegel, JN June, CH TI Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL ACTIVATION; TYROSINE KINASE P56LCK; LYMPHOCYTES-T; CD4; GP120; PERTURBATION; PHOSPHORYLATION; TRANSDUCTION; MOBILIZATION AB A variety of deficiencies in T cell activation have been described in HIV-1 infection. To determine whether one component of Ag receptor signal transduction might be impaired and contribute to the immunopathology of HIV infection, we tested CD4 cells from patients with early to mid-stage HIV infection for TCR-induced calcium mobilization. There was no detectable difference between patients and controls in the mean CD4 cell calcium response or in the fraction of responding CD4 cells after crosslinking the TCR with OKT3 Ab. in addition, in HIV-infected patients, there was no correlation between calcium mobilization and the CD4 cell count. These results indicate that there are no intrinsic impairments of Ag receptor calcium signaling in circulating CD4 cells from HIV-infected patients with >400 CD4 cells/mm(3), although abnormalities in patients with later stage infections cannot be excluded. C1 USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,TISSUE BANK,BETHESDA,MD 20889. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. FU NIAID NIH HHS [AI 22931] NR 44 TC 7 Z9 7 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 15 PY 1996 VL 156 IS 10 BP 4012 EP 4017 PG 6 WC Immunology SC Immunology GA UJ341 UT WOS:A1996UJ34100055 PM 8621943 ER PT J AU Barth, J AF Barth, J TI Restoring hope in America: The Social Security solution - Beard,S SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 15 PY 1996 VL 121 IS 9 BP 68 EP 68 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA UL204 UT WOS:A1996UL20400126 ER PT J AU Lee, ST Haetty, J Petrou, A Hawrylak, P Dutta, M Pamulapati, J Newman, PG TaysingLara, M AF Lee, ST Haetty, J Petrou, A Hawrylak, P Dutta, M Pamulapati, J Newman, PG TaysingLara, M TI Interband transitions in AlxGa1-xAs/AlAs quantum-well structures SO PHYSICAL REVIEW B LA English DT Article ID STAGGERED BAND ALIGNMENTS; RECOMBINATION MECHANISMS; ALAS; HETEROSTRUCTURES; SUPERLATTICES; GAAS AB We have studied the interband transitions from undoped and modulation-doped Al0.25Ga0.75As/AlAs multiple-quantum-well structures (the latter were doped n type in the Al0.25Ga0.75As layers). Two types of transitions have been observed: Type I associated with electron-hole recombination in the Al0.25Ga0.75As layers and type II between electrons in the Xxy and Xz valleys of the AlAs layers and holes confined in the Al0.25Ga0.75As layers. In undoped samples the luminescence associated with type-II transitions is dominated by phonon replicas. In contrast, the intensities of the zero-phonon X(xy)h(1) and X(z)h(1) transitions in modulation-doped samples are comparable to those of the replicas. Under optical pumping the type-II transitions in undoped samples show a pronounced blueshift due to band bending. Under high pumping intensity, the spectra from the undoped samples strongly resemble those from the modulation-doped structures. C1 NATL RES COUNCIL CANADA,INST MICROSTRUCT SCI,OTTAWA,ON K1A 0R6,CANADA. USA,RES LAB,FT MONMOUTH,NJ 07703. RP Lee, ST (reprint author), SUNY BUFFALO,DEPT PHYS,BUFFALO,NY 14260, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 15 PY 1996 VL 53 IS 19 BP 12912 EP 12916 DI 10.1103/PhysRevB.53.12912 PG 5 WC Physics, Condensed Matter SC Physics GA UM478 UT WOS:A1996UM47800062 ER PT J AU Casey, HC Muth, J Krishnankutty, S Zavada, JM AF Casey, HC Muth, J Krishnankutty, S Zavada, JM TI Dominance of tunneling current and band filling in InGaN/AlGaN double heterostructure blue light-emitting diodes SO APPLIED PHYSICS LETTERS LA English DT Article ID GAN GROWTH AB Measurement of the room temperature forward bias current-voltage behavior of InGaN/AlGaN double heterostructure blue light-emitting diodes demonstrates a significant departure from the usual I-s exp(qV/nkT) behavior where n is the ideality factor which varies between I and 2. The observed current-voltage behavior at room temperature may be represented as I=2.7x10(-11) exp(5.7V) which suggests a tunneling mechanism. Measurement of the electroluminescence for currents from 0.5 to 100 mA demonstrates that the emission peak shifts to higher energy while increasing in intensity. The shifting peak spectra is due to band filling, a process which results from the injection of holes via tunneling into an empty acceptor impurity band and vacant valence band tails. At currents near 100 mA, a non-shifting band-to-band emission approaches the intensity of the shifting peak spectra. The active layer of these diodes is codoped with both the donor Si and the acceptor Zn. (C) 1996 American Institute of Physics. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Casey, HC (reprint author), DUKE UNIV,DEPT ELECT & COMP ENGN,BOX 90291,DURHAM,NC 27708, USA. RI Muth, John/E-9027-2012 OI Muth, John/0000-0002-2488-7721 NR 17 TC 150 Z9 154 U1 2 U2 18 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 13 PY 1996 VL 68 IS 20 BP 2867 EP 2869 DI 10.1063/1.116351 PG 3 WC Physics, Applied SC Physics GA UK569 UT WOS:A1996UK56900032 ER PT J AU Zhang, JZ Yu, FTS McMillen, DK AF Zhang, JZ Yu, FTS McMillen, DK TI Coupling kinetics of the photorefractive hologram SO APPLIED OPTICS LA English DT Article DE photorefractive crystal; coupling; photorefractive filter ID CRYSTALS; GRATINGS; MEDIA AB The coupling kinetics of a reflection-type photorefractive hologram are studied, and we have found that the coupling between the adjacent channels increases as the reading time is prolonged. Our study shows that the reading beam is modulated by the grating in another channel for which it produces a weak backscattered light. As the backward-scattered light interacts with the reading beam, a new grating is formed; it in turn amplifies the backscattered light. Therefore the coupling increases rapidly compared with the normal fanning process. We have used Kukhtarev's charge-transport model to evaluate the time evolution of coupling. The calculated results are consistent with the experimental observation. (C) 1996 Optical Society of America C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP Zhang, JZ (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 14 TC 2 Z9 2 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 1996 VL 35 IS 14 BP 2355 EP 2359 DI 10.1364/AO.35.002355 PG 5 WC Optics SC Optics GA UL346 UT WOS:A1996UL34600003 PM 21085371 ER PT J AU Washington, GE AF Washington, GE TI An exactly solvable model for the collapsed state of Gaussian polymer chains SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID POROUS-MEDIA AB The influence of intermolecular and intramolecular interactions on the end-to-end distance is shown to be proportional to N--1/4, where N is the contour length of the polymer chain, for a single chain with intramolecular interactions. The same scaling behavior is obtained as a consequence of intermolecular interactions between two polymer chains. The apparent collapsed state chain size is reduced below that of experiment due to the absence of excluded volume. The onset of the collapsed state occurs above a threshold contour length at constant temperature where intramolecular interactions dominate the space of available conformations. RP Washington, GE (reprint author), USMA,DEPT CHEM,W POINT,NY 10966, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAY 8 PY 1996 VL 104 IS 18 BP 7284 EP 7288 DI 10.1063/1.471643 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA UJ114 UT WOS:A1996UJ11400038 ER PT J AU Xu, J McCarthy, SP Gross, RA Kaplan, DL AF Xu, J McCarthy, SP Gross, RA Kaplan, DL TI Chitosan film acylation and effects on biodegradability SO MACROMOLECULES LA English DT Article ID WATER-SOLUBLE CHITIN; CROSS-LINKING; MUCOR-ROUXII; CUPRIC ION; ADSORPTION; MEMBRANES AB Chitosan films were acylated under heterogeneous conditions in methanol with acetic and hexanoic anhydrides and characterized by proton nuclear magnetic resonance, elemental analysis, and multiple internal reflective Fourier transform infrared spectroscopy. The disappearance of the NH2 vibrational band at 1590 cm(-1), the appearance of the amide II band at 1555 cm(-1), and the relatively low intensity of the ester band at 1735 cm(-1) showed that acylation at the surface was site-selective for the amino (N) functionalities. Furthermore, N-acylation at the surface region appeared complete within 1 h. The acylated chitosan films were fractionated in aqueous acetic acid for compositional analysis. Acetylation of chitosan films for 3 h gave 52% of aqueous acetic acid insoluble chitin (outer film region) and 48% unreacted chitosan. In contrast, 3 h hexanoylation reactions resulted in <1% hexanoylation and a >99% aqueous acetic acid soluble product. Thus, film N-acetylation was more rapid than N-hexanoylation. Moreover, acetylation resulted in the formation of discrete outer chitin layers and an unreacted chitosan interior. The thickness of these film regions with different compositions may be controlled by the reaction conditions. Biodegradation studies of the acylated chitosan films carried out in laboratory-scale aerobic thermophilic compost reactors revealed that the formation of chitin at the film surface enhanced the biodegradability of the films. Specifically, the 3 h acetylated chitosan film (0.045 mm thickness) showed 100% weight loss during a 28 day exposure, whereas unmodified chitosan showed no significant weight loss after 35 days. C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. UNIV LOWELL,DEPT PLAST ENGN,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01769. NR 39 TC 164 Z9 173 U1 4 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 6 PY 1996 VL 29 IS 10 BP 3436 EP 3440 DI 10.1021/ma951638b PG 5 WC Polymer Science SC Polymer Science GA UK468 UT WOS:A1996UK46800016 ER PT J AU Liber, K Call, DJ Dawson, TD Whiteman, FW Dillon, TM AF Liber, K Call, DJ Dawson, TD Whiteman, FW Dillon, TM TI Effects of Chironomus tentans larval growth retardation on adult emergence and ovipositing success: Implications for interpreting freshwater sediment bioassays SO HYDROBIOLOGIA LA English DT Article DE Chironomus tentans; growth; emergence; sediment toxicity assessment ID METAL CONTAMINATED SEDIMENT; RELATIVE SENSITIVITY; RIPARIUS MEIGEN; ACUTE TOXICITY; LIFE STAGES; WATER; DIPTERA; COPPER; INVERTEBRATES; CADMIUM AB A laboratory study was conducted with Chironomus tentans to assess the significance of growth retardation of third-to fourth-instar larvae over a 10-d test period on long-term survival, adult emergence, and ovipositing success. Data were intended to provide interpretive guidance for the commonly used growth endpoint in 10-d sediment bioassays with C. tentans. Larval growth was controlled by using six feeding levels ranging from 0.2 to 5.9 mg dry weight Tetrafin(R) fish food per day. Mean 10-d survival was greater than or equal to 88% at all feeding levels, but larval growth decreased significantly (p<0.05) with each decrease in feeding level. Cumulative successful emergence of adult C. tentans decreased significantly with decreasing larval growth. Mean times to emergence always increased with decreasing growth rates and effects were generally more pronounced for females than males. At the lowest 10-d mean growth where successful emergence occurred (0.27 mg), the times to emergence doubled relative to the times observed at the highest 10-d mean growth (1.03 mg). Ten-day larval growth retardation was strongly correlated with reduction in adult emergence success (r(2) = 0.96). Growth retardations greater than or equal to> 64% resulted in 86-100% reductions in adult emergence. Growth retardation in the range of 35 to 50% equated with comparable percent reductions in adult emergence success. Although fewer females successfully emerged at 10-d growths of 0.37 and 0.74 mg relative to the highest 10-d growth (1.03 mg), ovipositing success of these females did not appear to be adversely affected by either their slower growth rates or their lower mean dry weights (0.62 and 0.99 mg, respectively). Growth of second generation larvae did not appear to be affected by maternal growth rate, but rather appeared to be solely correlated with their own feeding level. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP Liber, K (reprint author), UNIV WISCONSIN,LAKE SUPER RES INST,SUPERIOR,WI 54880, USA. NR 32 TC 45 Z9 45 U1 1 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD MAY 3 PY 1996 VL 323 IS 3 BP 155 EP 167 DI 10.1007/BF00007844 PG 13 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA UT850 UT WOS:A1996UT85000001 ER PT J AU Ayyagari, M Akkara, JA Kaplan, DL AF Ayyagari, M Akkara, JA Kaplan, DL TI Enzyme-mediated polymerization reactions: Peroxidase-catalyzed polyphenol synthesis SO ACTA POLYMERICA LA English DT Article ID ORGANIC-SOLVENTS; HORSERADISH-PEROXIDASE; NONAQUEOUS MEDIA; LIGNIN; POLYMERS; PHENOLS; CRESOL; AMINO; WATER AB Peroxidase-catalyzed phenol polymerization in the presence of hydrogen peroxide has been extensively studied. The process offers many advantages over the conventional chemical process to produce phenol-based resins. The enzymatic process avoids the use of formaldehyde and results in minimal formation of by-products due to high specificity of the enzyme toward the reactants. A number of phenolic derivatives and aromatic amines can be polymerized in different reaction systems, such as bulk solvents, reversed micelles and Langmuir trough. The polymers produced exhibit morphology reflective of the templating effect of the medium used to prepare the materials. Polymer molecular weight and polydispersity can be controlled by suitable design of the reaction medium. Polymer characteristics such as structure, thermal and temporal stability, functionalization and processability are reviewed. Conductivity, nonlinear optical and related functional properties are discussed with regard to potential applications. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. RP Ayyagari, M (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 67 TC 60 Z9 62 U1 2 U2 8 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0323-7648 J9 ACTA POLYM JI Acta Polym. PD MAY PY 1996 VL 47 IS 5 BP 193 EP 203 DI 10.1002/actp.1996.010470501 PG 11 WC Polymer Science SC Polymer Science GA UM165 UT WOS:A1996UM16500001 ER PT J AU Staecker, H GalinovicSchwartz, V Liu, W Lefebvre, P Kopke, R Malgrange, B Moonen, G VandeWater, TR AF Staecker, H GalinovicSchwartz, V Liu, W Lefebvre, P Kopke, R Malgrange, B Moonen, G VandeWater, TR TI The role of the neurotrophins in maturation and maintenance of postnatal auditory innervation SO AMERICAN JOURNAL OF OTOLOGY LA English DT Article; Proceedings Paper CT 128th Annual Meeting of the American-Otological-Society CY APR 29-30, 1995 CL PALM DESERT, CA SP Amer Otol Soc DE brain-derived neurotrophic factor; neurotrophin; growth factors ID NERVE GROWTH-FACTOR; SURVIVAL; NEURONS; RAT; GANGLION; BDNF AB Auditory hair cells produce trophic factors that directly affect maturation and survival of auditory neurons. These factors include two members of the neurotrophin family: brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Loss of hair cells as a result of either noise trauma or ototoxic damage, results In the degeneration of auditory neurons. An in vitro model of early postnatal rat organ of Corti/spiral ganglion explants was used to study the effects of deprivation and supplementation of nerve growth factor (NGF), BDNF, and NT-3 on neuronal survival. Immunolocalization of receptors for these neurotrophins correlated with their effectiveness as promoters of neuronal survival. BDNF affected early neuronal survival, whereas NT-3 was the most important survival factor for maturing auditory neurons. NGF was shown to maintain axonal morphology. Our results support the hypothesis that changes in the expression of these neurotrophins and their specific receptors in the maturing cochlea may control the postnatal processes of neuronal apoptosis and maturation of the innervation of both inner and outer hair cells. The results suggest that these growth factors have potential for preventing neuronal degeneration as well as enhancing the repair of damaged neuronal processes in the traumatized auditory system. C1 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OTOLARYNGOL,BRONX,NY 10461. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461. USA,MED DEPT CTR & SCH,FT SAM HOUSTON,TX. UNIV LIEGE,DEPT HUMAN PHYSIOL & PATHOPHYSIOL,LIEGE,BELGIUM. OI Staecker, Hinrich/0000-0002-0348-3015; Malgrange, Brigitte/0000-0002-8957-2528 FU NIDCD NIH HHS [DC00088] NR 23 TC 26 Z9 30 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-9763 J9 AM J OTOL JI Am. J. Otol. PD MAY PY 1996 VL 17 IS 3 BP 486 EP 492 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA UV040 UT WOS:A1996UV04000021 PM 8817030 ER PT J AU Rothwell, SW Putnak, R LaRussa, VF AF Rothwell, SW Putnak, R LaRussa, VF TI Dengue-2 virus infection of human bone marrow: Characterization of dengue-2 antigen-positive stromal cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RECEPTOR; INVITRO; PROGENITORS; INVIVO AB Dengue is often associated with neutropenia and thrombocytopenia, suggesting that cells of the bone marrow may be targets of dengue viral infections. In this study we infected long-term marrow cultures with dengue type-2 (DEN-2) virus and characterized the viral antigen-positive cells. Using immunofluorescence microscopy and immunohistochemical staining, we demonstrated two types of stromal cells that were positive for DEN-2 virus antigens. The first was a population of relatively small (approximately 25 mu m) CD11b/CD18 (MAC-1)-positive cells. When stained with anti-DEN-2 polyclonal antibody, these cells showed viral antigen-positive inclusions and, when stained with anti-tubulin or anti-vimentin antibodies, they showed a diffuse pattern of fluorescence, consistent with mobile dendritic cells with phagocytic functions. The second population of DEN-2 antigen-positive cells comprised a smaller proportion of the total cells. It was made up of larger cells (> 100 mu m) that had a well-formed cytoskeletal system as demonstrated by intense staining with anti-actin, anti-tubulin, and anti-vimentin antibodies. When stained with anti-DEN-2 antibody, these cells showed a more diffuse pattern of fluorescence in the perinuclear and Golgi regions, consistent with ongoing virus replication. These large, strongly adherent cells were positive for nerve growth factor receptor, consistent with their identification as adventitial reticular cells. The molecule that mediates the virus interaction with susceptible cells has not previously been identified. Using plasma membrane proteins isolated from K562 cells, virus-binding studies suggest that an approximately 100-kD membrane protein may be involved in the initial virus-cell interaction. C1 WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. RP Rothwell, SW (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307, USA. NR 27 TC 39 Z9 39 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1996 VL 54 IS 5 BP 503 EP 510 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA UP632 UT WOS:A1996UP63200012 PM 8644906 ER PT J AU Johnson, AA Burleson, DG AF Johnson, AA Burleson, DG TI Nitrate analysis in biological fluids by gas chromatography nitrogen-phosphorous detection SO ANALYTICAL BIOCHEMISTRY LA English DT Article AB Nitrate analysis in body fluids is an important part of the study of nitric oxide metabolism, A sensitive, simple procedure for nitrate analysis was developed by producing nitrobenzene from the nitrate in the samples and benzene. The nitrobenzene produced was measured on a gas chromatograph (GC) equipped with a nitrogen-phosphorous detector. Cl-, which interfered with the derivitization procedure, was removed as silver chloride after precipitation with silver lactate. Rat urine samples were also analyzed after elution through a C18 reverse-phase sample preparation column to remove organic molecules that competed with benzene for the nitrate in the sample. A benzene derivative, 2-nitro-1,3-dimethylbenzene (a-nitro-m-xylene), was chosen as an internal standard for GC analysis. Recovery of nitrate was 67 +/- 2% in serum and 87 +/- 8% in urine. Sensitivity of the procedure was 1 mu M. This procedure offers improvements in sensitivity, simplicity, and consistency over previously published procedures and makes possible the measurement of nitrate and determination of isotopic ratios by GC-MS on the same sample. (C) 1996 Academic Press, Inc. RP Johnson, AA (reprint author), USA,INST SURG RES,2232 HARNEY RD,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 19 Z9 19 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD MAY 1 PY 1996 VL 236 IS 2 BP 331 EP 337 DI 10.1006/abio.1996.0175 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA UJ495 UT WOS:A1996UJ49500020 PM 8660513 ER PT J AU Mongan, PD Hinman, JA AF Mongan, PD Hinman, JA TI You found it where?!? Reply SO ANESTHESIOLOGY LA English DT Letter ID VENOUS AIR-EMBOLISM; RESUSCITATION; CATHETER; RETRIEVAL; DOGS RP Mongan, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD MAY PY 1996 VL 84 IS 5 BP 1265 EP 1265 DI 10.1097/00000542-199605000-00039 PG 1 WC Anesthesiology SC Anesthesiology GA UJ071 UT WOS:A1996UJ07100040 ER PT J AU Degnan, BM BourdelatParks, B Daniel, A Salata, K Francis, GL AF Degnan, BM BourdelatParks, B Daniel, A Salata, K Francis, GL TI Sphingomyelinase inhibits in vitro Leydig cell function SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article ID TUMOR-NECROSIS-FACTOR; PLASMA-MEMBRANE SPHINGOMYELIN; PITUITARY-HORMONE-RELEASE; GENE-EXPRESSION; FACTOR-ALPHA; CACHECTIN; CHOLESTEROL; INTERLEUKIN-1; FIBROBLASTS; METABOLISM AB Activation of the immune system has profound effects on endocrine function which are mediated by cytokines including tumor necrosis factor-alpha (TNF alpha). In vitro, TNF alpha has been shown to directly inhibit Leydig cell testosterone (T) production, but the mechanism of this effect is still unclear. Recent studies using cultured human fibroblasts have shown that TNF alpha stimulates the activity of neutral sphingomyelinase (SMase) which hydrolyses sphingomyelin (SM) generating ceramide and changing membrane components including cholesterol. The cellular effects of increased SMase activity have been reproduced in vitro by the addition of exogenous SMase. III cultured fibroblasts, exogenous SMase decreases cholesterol synthesis. These findings led us to hypothesize that SMase might be important in the regulation of steroid hormone synthesis. To our knowledge, no previous studies have investigated this possibility. To test this hypothesis, rat Leydig cell enriched cultures were incubated in media containing SMase (0.1 to 100 mU/ml) or in control media. SMase significantly decreased basal and human chorionic gonadotropin (hCG) stimulated T production. SMase also decreased hCG binding and hCG stimulated adenosine 3':5'-cyclic monophosphate (cAMP). N-acetyl-sphingosine (0.1 to 10 mu M), a water soluble ceramide, was used to determine whether or not the effects of SMase could be reproduced by ceramide addition. N-acetyl-sphingosine had only slight effects an basal T and cAMP, and no effect on hCG binding or hCG stimulated T or cAMP. These data suggest the metabolism of membrane sphingomyelin may be an important regulatory pathway in the control of Leydig cell function. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,F EDWARD HERBERT SCH MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. OGLETHORPE UNIV,ATLANTA,GA 30319. NR 30 TC 7 Z9 8 U1 0 U2 1 PU INST CLINICAL SCIENCE INC PI PHILADELPHIA PA 1833 DELANCEY PLACE, PHILADELPHIA, PA 19103 SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD MAY-JUN PY 1996 VL 26 IS 3 BP 234 EP 242 PG 9 WC Medical Laboratory Technology SC Medical Laboratory Technology GA UG104 UT WOS:A1996UG10400005 PM 8726216 ER PT J AU Doyle, JJ Hnatiuk, OW Torrington, KG Slade, AR Howard, RS AF Doyle, JJ Hnatiuk, OW Torrington, KG Slade, AR Howard, RS TI Necessity of routine chest roentgenography after thoracentesis SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID COMPLICATIONS; THORACOCENTESIS AB Objective: To determine the necessity of posteroanterior chest roentgenography for the identification of pneumothorax and other complications after thoracentesis. Design: Prospective cohort study. Setting: Tertiary care teaching hospital. Patients: 67 men and 43 women (mean age +/- SD, 62.4 +/- 13.2 years). Exclusion criteria included age younger than 18 years, concurrent pleural biopsy, ultrasound guidance, and use of mechanical ventilation. Measurements: 174 thoracenteses done between March 1991 and June 1993. Results: 2 hemothoraces (1.2%) occurred, and 8 patients had a total of 9 pneumothoraces (5.2%). The roentgenograms obtained immediately after the procedures identified 8 pneumothoraces; the other pneumothorax was seen incidentally on a delayed roentgenogram obtained 3 days later. Pneumothorax was suspected in 5 of the 8 cases, and tube thoracostomy was done in 4 of these 5 cases. Patients with unsuspected pneumothorax identified on the roentgenogram obtained immediately after the procedure did not receive treatment for their pneumothoraces. Univariate analysis showed that the variables that correlated significantly with pneumothorax were aspiration of air during the procedure (relative risk ratio, 12.3; 95% CI, 3.7 to 41.4), number of passes with the thoracentesis needle (relative risk ratio, 6.1; CI, 1.6 to 23.3), history of thoracic radiation therapy (relative risk ratio, 10.5; CI, 2.5 to 44.4), and operator suspicion of pneumothorax (relative risk ratio, 25.9; CI, 8.6 to 78.5). Conclusion: Among hospitalized patients with pleural effusions, we identified a subgroup of patients in whom the risk for pneumothorax is low enough (approximately 1%) with sufficiently minimal clinical consequences to justify the avoidance of about 60% of chest roentgenograms obtained after thoracentesis. These patients are clinically stable, have not previously received chest irradiation, had only one pass at thoracentesis attempted without the aspiration of any air, and give no other indication of pneumothorax. C1 WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 12 TC 48 Z9 51 U1 1 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAY 1 PY 1996 VL 124 IS 9 BP 816 EP 820 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA UG254 UT WOS:A1996UG25400005 PM 8610950 ER PT J AU Jones, SF Burris, HA AF Jones, SF Burris, HA TI Vinorelbine: A new antineoplastic drug for the treatment of non-small-cell lung cancer SO ANNALS OF PHARMACOTHERAPY LA English DT Article ID COOPERATIVE-ONCOLOGY-GROUP; PHASE-II; RANDOMIZED TRIAL; NAVELBINE; CHEMOTHERAPY; VINBLASTINE; TAXOL AB OBJECTIVE: To review the chemistry, pharmacology, pharmacokinetics, clinical activity, adverse effects, and dosage and administration guidelines for vinorelbine in the treatment of non-small-cell lung cancer (NSCLC). DATA SOURCES: A MEDLINE search (1989-1995) using the terms vinorelbine and Navelbine was conducted. Additional unpublished data were provided by Glare Wellcome Drug information. STUDY SELECTION AND DATA EXTRACTION: The articles chosen for inclusion all appeared in peer-reviewed journals. Pertinent abstracts, as judged by the authors, were also included. DATA SYNTHESIS: Vinorelbine is a new semisynthetic vinca alkaloid approved by the Food and Drug Administration for the first-line treatment of patients with advanced NSCLC. The drug demonstrated a broad spectrum of antitumor activity in preclinical studies and produced dose-limiting neutropenia in Phase I trials. In Phase ii studies, an overall response rate of approximately 30% was reported with single-agent vinorelbine. Furthermore, in large, multicenter, randomized Phase III trials, treatment with vinorelbine alone and in combination with cisplatin resulted in improved survival compared with controls. The drug was well tolerated, with granulocytopenia being the most commonly reported adverse effect. However, the incidence of fever and hospitalization associated with this granulocytopenia was exceptionally low. The recommended dose is 30 mg/m(2) weekly administered by intravenous injection or infusion. CONCLUSIONS: As no specific chemotherapy regimen has previously been regarded as standard therapy for advanced NSCLC, vinorelbine is a promising new treatment for this patient population. It has been shown in several randomized, controlled trials to increase survival without compromising quality of life. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP Jones, SF (reprint author), TYLER HEMATOL ONCOL PA,619 S FLEISHEL,SUITE 308,TYLER,TX 75701, USA. NR 29 TC 8 Z9 10 U1 0 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD MAY PY 1996 VL 30 IS 5 BP 501 EP 506 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UJ215 UT WOS:A1996UJ21500013 PM 8740332 ER PT J AU Dudley, D AF Dudley, D TI Safety nets, politics, and the poor: Transitions to market economies - Graham,C SO ANNALS OF THE AMERICAN ACADEMY OF POLITICAL AND SOCIAL SCIENCE LA English DT Book Review RP Dudley, D (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0002-7162 J9 ANN AM ACAD POLIT SS JI Ann. Am. Acad. Polit. Soc. Sci. PD MAY PY 1996 VL 545 BP 210 EP 210 DI 10.1177/0002716296545001043 PG 1 WC Political Science; Social Sciences, Interdisciplinary SC Government & Law; Social Sciences - Other Topics GA UG665 UT WOS:A1996UG66500048 ER PT J AU Cheng, TC Harvey, SP Chen, GL AF Cheng, TC Harvey, SP Chen, GL TI Cloning and expression of a gene encoding a bacterial enzyme for decontamination of organophosphorus nerve agents and nucleotide sequence of the enzyme SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID PSEUDOMONAS-DIMINUTA; PROLIDASE DEFICIENCY; HYDROLYZING ENZYME; ESCHERICHIA-COLI; PURIFICATION; PHOSPHOTRIESTERASE; OPD AB Organophosphorus acid (OPA) anhydrolase enzymes have been found in a wide variety of prokaryotic and eukaryotic organisms. Interest in these enzymes has been prompted by their ability to catalyze the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents. The natural substrates for these enzymes are unknown. The gene (opaA) which encodes an OPA. anhydrolase (OPAA-2) was isolated from an Alteromonas sp. strain JD6.5 EcoRI-lambda ZAPII chromosomal library expressed in Escherichia coli and identified by immunodetection with anti-OPAA-2 serum. OPA anhydrolase activity expressed by the immunopositive recombinant clones was demonstrated by using diisopropylfluorophosphate (DFP) as a substrate. A comparison of the recombinant enzyme with native, purified OPAA-2 showed they had the same apparent molecular mass (60 kDa), antigenic properties, and enzyme activity against DFP and the chemical nerve agents sarin, soman, and O-cyclohexyl methylphosphonofluoridate. The gene expressing this activity aas found in a 1.74-kb PstI-HindIII fragment of the original 6.1-kb EcoRI DNA insert. The nucleotide sequence of this PstI-HindIII fragment revealed an open reading frame of 1,551 nucleotides, coding for a protein of 517 amino acid residues. Amino acid sequence comparison of OPAA-2 with the protein database showed that OPAA-2 is similar to a 647-amino-acid sequence produced by an open reading frame which appears to be the E. coli pepQ gene. Further comparison of OPAA-2, the E. coli PepQ protein sequence, E. coli aminopeptidase P. and human prolidase showed regions of different degrees of similarity or functionally conserved amino acid substitutions. These findings, along with preliminary data confirming the presence of prolidase activity expressed by OPAA-2, suggest that the OPAA-2 enzyme may, in nature, be used in peptide metabolism. C1 KENNEDY KRIEGER INST, BALTIMORE, MD 21005 USA. RP Cheng, TC (reprint author), USA, EDGEWOOD RES, CTR DEV & ENGN, RES & TECHNOL DIRECTORATE, ABERDEEN PROVING GROUND, MD 21010 USA. NR 32 TC 83 Z9 95 U1 4 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAY PY 1996 VL 62 IS 5 BP 1636 EP 1641 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA UJ228 UT WOS:A1996UJ22800024 PM 8633861 ER PT J AU Spiers, PA Myers, D Hochanadel, GS Lieberman, HR Wurtman, RJ AF Spiers, PA Myers, D Hochanadel, GS Lieberman, HR Wurtman, RJ TI Citicoline improves verbal memory in aging SO ARCHIVES OF NEUROLOGY LA English DT Article ID CHOLINERGIC HYPOTHESIS; CDP-CHOLINE; IMPAIRMENT; SCOPOLAMINE AB Objective: To test the verbal memory of older volunteers given citicoline. Design: A randomized, double-blind, placebo-controlled, parallel group design was employed in the initial study. After data analysis, a subgroup was identified whose members had relatively inefficient memories. These subjects were recruited for a second study that used a crossover design. The subjects took either placebo or citicoline, 1000 mg/d, for 3 months in the initial study. In the crossover study, subjects took both placebo and citicoline, 2000 mg/d, each for 2 months. Subjects: The subjects were 47 female and 48 male volunteers 50 to 85 years old. They were screened for dementia, memory disorders, and other neurological problems. Of the subjects with relatively inefficient memories, 32 participated in the crossover study. Main Outcome Measure: Verbal memory was tested at each study visit using a logical memory passage. Plasma choline concentrations were measured at baseline; at days 30, 60, and 90 in the initial study; and at day 60 of each treatment condition in the crossover study. Plasma choline concentrations and memory scores were analyzed using repeated-measures analysis of variance and covariance, followed by planned comparisons when appropriate. Results: In the initial study, citicoline therapy improved delayed recall on logical memory only for the subjects with relatively inefficient memories. In the crossover study, the higher dosage of citicoline was clearly associated with improved immediate and delayed logical memory. Conclusions: Citicoline therapy improved verbal memory functioning in older individuals with relatively inefficient memories. Citicoline may prove effective in treating age-related cognitive decline that may be the precursor of dementia. C1 MIT, DEPT BRAIN & COGNIT SCI, CAMBRIDGE, MA 02139 USA. USA, ENVIRONM MED RES INST, NATICK, MA 01760 USA. RP Spiers, PA (reprint author), MIT, CLIN RES CTR, 77 MASSACHUSETTS AVE, CAMBRIDGE, MA 02139 USA. FU NCRR NIH HHS [MO1-RR-00088]; NIMH NIH HHS [MH-28783] NR 34 TC 68 Z9 70 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD MAY PY 1996 VL 53 IS 5 BP 441 EP 448 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA UJ821 UT WOS:A1996UJ82100017 PM 8624220 ER PT J AU Pickett, BP Burgess, LPA Livermore, GH Tzikas, TL Vossoughi, J AF Pickett, BP Burgess, LPA Livermore, GH Tzikas, TL Vossoughi, J TI Wound healing - Tensile strength vs healing time for wounds closed under tension SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID CLOSING TENSION; RATS; LYMPHOCYTES AB Objectives: To measure tensile strength of wounds closed with and without tension in rats, delineating the postoperative time interval when tensile strength is equal. To study patterns of growth in tensile strength. Design: Transverse incisions on the backs of control rats were closed with minimal tension. In experimental animals, after excision of skin from the back, wounds were closed with closing tensions in excess of 70 g. Animals were killed at designated healing intervals for tensile-strength testing of wounds. Subjects: One hundred Sprague-Dawley rats were divided into 5 groups, days 5, 7, 10, 14, and 21, with equal numbers of control and experimental animals in each group. Wounds from 94 animals were available for break-load testing. Intervention: Closing tensions were measured for transverse incisions on the backs of control animals before closure and after removal of 50 to 60 mm of skin from the backs of experimental animals. Results: Tensile strength was not significantly different on day 5. However, wounds closed under tension showed significantly higher tensile strength on days 7, 10: 14, and 21. Polynomial regression suggests a cubic relationship between healing time and tensile strength. Conclusions: Results suggest that tensile strength of wounds closed under tension exceeds that of tensionless wounds as early as day 7 following surgery. This study also illustrates the 2 periods of rapid increase in wound tensile strength that probably coincide with specific stages of wound healing. C1 WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. WINN ARMY HOSP,FT STEWART,GA. UNIV DIST COLUMBIA,ENGN RESOURCE CTR,WASHINGTON,DC. NR 24 TC 15 Z9 15 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAY PY 1996 VL 122 IS 5 BP 565 EP 569 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA UJ608 UT WOS:A1996UJ60800017 PM 8615976 ER PT J AU Rabin, J McLean, W AF Rabin, J McLean, W TI A comparison between phosphors for aviator's night vision imaging system SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID CONTRAST SENSITIVITY AB Background: The visual display on night vision goggles (NVG's) is green and isochromatic (P22 phosphor). Future systems are expected to use a P43 phosphor which has a narrower visible spectrum and is yellowish green, while the P22 is deeper green. In transitioning to the P43, some NVG's may have P22 and P43 phosphors paired in the same NVG. The purpose of this study was to evaluate the suitability of the P43 phosphor and the effect of mixing phosphors in the same NVG. Methods: We tested three systems: one with P22 phosphors in both tubes (P22), one with P43 in both tubes (P43), and one with P22 in the right and P43 in the left tube (mixed). Visual acuity (VA), contrast sensitivity (CS), flicker sensitivity, and dynamic CS were measured in six subjects with measures repeated across the three systems (P22, P43 and mixed). Results: There was no difference between systems in VA or CS across a range of simulated night sky conditions. There also was no difference between systems in sensitivity to flicker. Performance on dynamic CS was slightly better with the P43 display, which may relate to the faster decay time of this phosphor. Conclusions These results provide no contraindication for using the P43 phosphor in NVG's (paired or unpaired), but it would be prudent to minimize mixing of phosphors in the same NVG. Additional factors that may affect performance with different color displays are discussed. RP Rabin, J (reprint author), USA,AEROMED RES LAB,AIRCREW HLTH & PERFORMANCE DIV,FT RUCKER,AL 36362, USA. NR 25 TC 2 Z9 2 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 1996 VL 67 IS 5 BP 429 EP 433 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA UH185 UT WOS:A1996UH18500004 PM 8725468 ER PT J AU Capacio, BR Byers, CE Matthews, RL Chang, FCT AF Capacio, BR Byers, CE Matthews, RL Chang, FCT TI A method for determining 4-aminopyridine in plasma: Pharmacokinetics in anaesthetized guinea pigs after intravenous administration SO BIOMEDICAL CHROMATOGRAPHY LA English DT Article ID SERUM; 3,4-DIAMINOPYRIDINE; AMINOPYRIDINES AB An HPLC assay has been developed to measure 4-aminopyridine (4-AP) in guinea pig plasma, For the assay, all plasma samples (50 mu L) were microfiltered following the addition of an internal standard (3,4-diaminopyridine). Filtrates (10 mu L) were directly injected into a spherical silica column (100x2.1 mm; 5 mu m); detection was achieved at 266 nm. Standard curves had correlation coefficients ranging from 0.9923 to 0.9992 and coefficients of variation expressed as a percentage (%CV) of below 8%. Precision was expressed as between-day and within-day variability of five test sample concentrations. Between-day %CV ranged from 4.0 to 6.5%. Within-day % CV ranged from 3.6 to 6.9%. Accuracy was assessed by examining expected within-day test sample concentrations against calculated concentrations; per cent errors were all below 10%. Stability studies demonstrated %CV below 5% after repeated freezing, The method was employed to study the pharmacokinetics of 4-AP after intravenous administration to anaesthetized guinea pigs, Serial blood samples (150 mu L) were collected at predetermined time intervals up to 4 h post-4-AP (2 mg/kg, i,v,) administration, 4-AP demonstrated a biexponential decline in the plasma-concentration curve as a function of time indicating a two compartment model for this drug, Selected mean pharmacokinetic parameter estimates were alpha-half-life, 0.37 min; beta-half-life (biological half-life) for terminal slope, 109 min; and volume of distribution at steady state, 1036.18 mL/kg, 4-AP was found to rapidly and extensively partition into a peripheral tissue compartment and demonstrated a relatively long biological half-life, The findings from the current pharmacokinetic experiments support the pharmacology of 4-AP in its role for reversing saxitoxin (STX)- and tetrodotoxin (TTX)-induced diaphragmatic failure in terms of onset of action and duration of effect in anaesthetized guinea pigs. RP Capacio, BR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 9 Z9 9 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0269-3879 J9 BIOMED CHROMATOGR JI Biomed. Chromatogr. PD MAY-JUN PY 1996 VL 10 IS 3 BP 111 EP 116 DI 10.1002/(SICI)1099-0801(199605)10:3<111::AID-BMC569>3.3.CO;2-5 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA UN315 UT WOS:A1996UN31500002 PM 8792860 ER PT J AU Bruno, JG Sincock, SA Stopa, PJ AF Bruno, JG Sincock, SA Stopa, PJ TI Highly selective acridine and ethidium staining of bacterial DNA and RNA SO BIOTECHNIC & HISTOCHEMISTRY LA English DT Article DE acridine dyes; ethidium bromide; gel electrophoresis; DNA; RNA; proteins; fluorescence ID POLYACRYLAMIDE GELS; ORANGE; ELECTROPHORESIS; FLUORESCENCE; NEUTROPHILS; PROTEINS AB The acridine dyes acridine orange (AO) and coriphosphine O (CPO) and ethidium bromide (EtBr) were used to stain bacterial digests after electrophoresis in native and denaturing (SDS) polyacrylamide gels and were shown to stain DNA and RNA preferentially over other subcellular components in the gels. Vegetative cell digests of Bacillus subtilis, Escherichia coli, Micrococcus luteus, and Staphylococcus aureus showed intense staining of DNA with AO and CPO near the top of the gel, but little or no staining of other cellular constituents. EtBr stained both DNA and RNA in the gels. Protein standards and non-nucleic acid cellular constituents stained faintly with high concentrations [greater than or equal to 100 mu M] of AO, lower concentrations (13.9 mu M) of CPO, and did not stain with 0.5 mu g/ml EtBr in denaturing gels. The complete set of cellular biochemicals was visualized by silver staining, while the protein subset was detected by Coomassie blue staining. The highest concentrations of AO (120 mu M) and CPO (13.9 mu M) were shown to detect purified DNA in gels with a sensitivity in the range of 25-50 ng per band. This work demonstrates the specificity of acridine and ethidium dyes for nucleic acids, while illustrating the level of non-nucleic acid-specific interactions with other cellular components by staining of electrophoretically separated cellular components in a gel matrix. C1 SCI & TECHNOL CORP, EDGEWOOD, MD 21040 USA. USA, EDGEWOOD RES DEV & ENGN CTR, SCBRD, RTE, ABERDEEN PROVING GROUND, MD 21010 USA. RP APPL RES ASSOCIATES, ARMSTRONG LAB,ENVIRON DIRECTORATE,139 BARNES DR, SUITE 2, BLDG 1117, TYNDALL AFB, FL 32403 USA. NR 25 TC 7 Z9 7 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1052-0295 EI 1473-7760 J9 BIOTECH HISTOCHEM JI Biotech. Histochem. PD MAY PY 1996 VL 71 IS 3 BP 130 EP 136 DI 10.3109/10520299609117149 PG 7 WC Biotechnology & Applied Microbiology; Cell Biology SC Biotechnology & Applied Microbiology; Cell Biology GA UL575 UT WOS:A1996UL57500005 PM 8724438 ER PT J AU Rushing, EJ Armonda, RA Ansari, Q Mena, H AF Rushing, EJ Armonda, RA Ansari, Q Mena, H TI Mesenchymal chondrosarcoma - A clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system SO CANCER LA English DT Article DE mesenchymal chondrosarcoma, brain and spinal cord; DNA flow cytometry; immunohistochemistry ID SPINE AB BAGKGROUND. Mesenchymal chondrosarcomas arising in the central nervous system are extremely rare. Morphologic features have not been found to correlate reliably with prognosis. METHODS, Eight intracranial and five intraspinal mesenchymal chondrosarcomas were reviewed with regard to location, treatment, and long term follow-up data. The histopathologic and immunohistochemical results, including Ki-67 nuclear staining frequency, were critically reviewed, and deoxyribonucleic acid content was analyzed by flow cytometry. RESULTS, Microscopically, all 13 cases were remarkably similar. Immunoreactivity in the small cell component included vimentin in 100%, and cytokeratin and glial fibrillary acidic protein in 25% of cases. S-100 immunoreactivity was noted in the cartilaginous component of 100% of cases, and in rare cells in the small cell component along the interface. Flow cytometry of the eight tumors studied revealed a diploid pattern in six, aneuploidy in two, and a wide range of S-phase fractions (0-36.5%). CONCLUSIONS. Review of the literature and the findings of the current series indicates that mesenchymal chondrosarcomas presenting in the brain and spinal cord pursue a progressive course that correlates most reliably with extent of surgical resection. This limited retrospective study also suggests that survival maybe shorter for those patients with a high S-phase fraction and a high Ki-67 staining frequency. C1 WALTER REED ARMY MED CTR,DEPT NEUROSURG,WASHINGTON,DC 20307. UNIV TEXAS,SW MED CTR,DEPT PATHOL,FLOW CYTOMETRY LAB,DALLAS,TX. ARMED FORCES INST PATHOL,DEPT NEUROPATHOL,WASHINGTON,DC 20306. RP Rushing, EJ (reprint author), UNIV TEXAS,SW MED CTR,DEPT PATHOL,NEUROPATHOL LAB,5323 HARRY HINES BLVD,DALLAS,TX 75235, USA. NR 36 TC 56 Z9 59 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAY 1 PY 1996 VL 77 IS 9 BP 1884 EP 1891 PG 8 WC Oncology SC Oncology GA UF719 UT WOS:A1996UF71900019 PM 8646689 ER PT J AU Schatzkin, A Lanza, E Freedman, LS Tangrea, J Cooper, MR Marshall, JR Murphy, PA Selby, JV Shike, M Schade, RR Burt, W Kikendall, JW Cahill, J AF Schatzkin, A Lanza, E Freedman, LS Tangrea, J Cooper, MR Marshall, JR Murphy, PA Selby, JV Shike, M Schade, RR Burt, W Kikendall, JW Cahill, J TI The Polyp Prevention Trial I: Rationale, design, recruitment, and baseline participant characteristics SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID COLON CANCER; COLORECTAL-CANCER; DIETARY FIBER; EPIDEMIOLOGIC EVIDENCE; ADENOMATOUS POLYPS; UNITED-STATES; RISK; CARCINOGENESIS; SURVEILLANCE; MORTALITY AB The Polyp Prevention Trial (PPT) is a multicenter randomized controlled trial examining the effect of a low-fat (20% of total energy intake), high-fiber (18 g/1000 kcal), high-vegetable and -fruit (5-8 daily servings) dietary pattern on the recurrence of adenomatous polyps of the large bowel, precursors of most colorectal malignancies. Eligibility criteria include one or more adenomas removed within 6 months of randomization; complete nonsurgical polyp removal and complete colonic examination to the cecum at the qualifying colonoscopy; age 35 years or more; no history of colorectal cancer, inflammatory bowel disease, or large bowel resection; and satisfactory completion of a food frequency questionnaire and 4-day food record. Of approximately 38,277 potential participants with one or more polyps recently resected, investigators at eight clinical centers randomized 2,079 (5.4%; 1,037 in the intervention and 1,042 in the control arm) between June 1991 and January 1994, making the PPT the largest adenoma recurrence trial ever conducted. Of PPT participants, 35% are women and 10% are minorities. At study entry, participants averaged 61.4 Sears of age; 14% of them smoked, and 22% used aspirin. At the baseline colonoscopy, 35% of participants had two or more adenomas, and 29% had at least one large (greater than or equal to 1 cm) adenoma. Demographic, behavioral, dietary, and clinical characteristics are comparable across the two study arms. Participants have repeat colonoscopies after 1 (T-1) and 4 (T-4) years of follow-up. The primary end point is adenoma recurrence; secondary end points include number, size, location, and histology of adenomas. All resected lesions are reviewed centrally by gastrointestinal pathologists. The trial provides 90% power to detect a reduction of 24% in the annual adenoma recurrence rate. The primary analytic period, on which sample size calculations were based, is 3 years (T-1 to T-4), which permits a 1-year lag time for the intervention to work and allows a more definitive clearing of lesions at T-1, given that at least 10-15% of polyps may be missed at baseline, The final (T-4) colonoscopies are expected to be completed in early 1998. C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC. SUNY BUFFALO,SCH MED & BIOMED SCI,BUFFALO,NY. US DEPT VET AFFAIRS,VET AFFAIRS EDWARD HINES JR HOSP,HINES,IL 60141. KAISER FDN RES INST,OAKLAND,CA. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. UNIV PITTSBURGH,PITTSBURGH,PA. UNIV UTAH,SALT LAKE CITY,UT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WESTAT CORP,ROCKVILLE,MD. RP Schatzkin, A (reprint author), NCI,DEPT HLTH & HUMAN SERV,PUBL HLTH SERV,NIH,BETHESDA,MD 20892, USA. NR 50 TC 82 Z9 84 U1 0 U2 7 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD MAY PY 1996 VL 5 IS 5 BP 375 EP 383 PG 9 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA UJ727 UT WOS:A1996UJ72700009 PM 9162304 ER PT J AU Lanza, E Schatzkin, A BallardBarbash, R Clifford, DC Paskett, E Hayes, D Bote, E Caan, B Shike, M Weissfeld, J Slattery, M Mateski, D AF Lanza, E Schatzkin, A BallardBarbash, R Clifford, DC Paskett, E Hayes, D Bote, E Caan, B Shike, M Weissfeld, J Slattery, M Mateski, D TI The Polyp Prevention Trial II: Dietary intervention program and participant baseline dietary characteristics SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID DENSITY-LIPOPROTEIN CHOLESTEROL; SELF-EFFICACY; CANCER; VEGETABLES; FAT; QUESTIONNAIRE; REDUCTION; FIBER; FRUIT; RISK AB The Polyp Prevention Trial (PPT) is a multicenter randomized controlled trial to evaluate whether a low-fat, high-dietary fiber, high-fruit and -vegetable eating pattern will reduce the recurrence of adenomatous polyps of the large bowel. Men and women who had one or more adenomas removed recently were randomized into either the intervention (it = 1037) or control (it = 1042) arms, Food frequency questionnaire data indicate that PPT participants at the beginning of the trial consumed 36.8% of total energy from fat, 9.7 g of dietary fiber/1000 kcal, and 3.8 daily servings of fruits and vegetables, Baseline dietary characteristics, including intake of fat, fiber, and fruits and vegetables, as well as other macro- and micronutrients, were similar in the two study groups, The intervention participants receive extensive dietary and behavioral counseling to achieve the PPT dietary goals of 20% of total energy from fat, 18 g/1000 kcal of dietary fiber, and 5-8 daily servings (depending on total caloric intake) of fruits and vegetables, Control participants do not receive such counseling and are expected to continue their usual intake, Dietary intake in both groups is monitored annually using a 4-day food record (also completed at 6 months by intervention participants only) and a food frequency questionnaire, with a 10% random sample of participants completing an annual unscheduled 24-h telephone recall, Blood specimens are drawn and analyzed annually for lipids and carotenoids, This article provides details on the rationale and design of the PPT dietary intervention program and describes the participant baseline dietary intake data characteristics. C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC. SUNY BUFFALO,SCH MED & BIOMED SCI,BUFFALO,NY. US DEPT VET AFFAIRS,VET AFFAIRS EDWARD HINES JR HOSP,HINES,IL 60141. KAISER FDN RES INST,OAKLAND,CA. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. UNIV PITTSBURGH,PITTSBURGH,PA. UNIV UTAH,SALT LAKE CITY,UT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WESTAT CORP,ROCKVILLE,MD. NR 52 TC 66 Z9 66 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD MAY PY 1996 VL 5 IS 5 BP 385 EP 392 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA UJ727 UT WOS:A1996UJ72700010 PM 9162305 ER PT J AU McCarthy, MJ Lillis, P Vukelja, SJ AF McCarthy, MJ Lillis, P Vukelja, SJ TI Azathioprine as a steroid-sparing agent in radiation pneumonitis SO CHEST LA English DT Article DE azathioprine; corticosteroids; pneumonitis; radiation ID THERAPY; LUNG; INJURY AB Radiation therapy is commonly used for treatment of neoplastic disease involving the thorax. Treatment complications include radiation pneumonitis that may require therapy with corticosteroids which possess significant side effects. We report the use of azathioprine as a steroid-sparing agent in a patient with severe radiation pneumonitis and steroid-induced myopathy. C1 BROOKE ARMY MED CTR,DEPT RADIOL,RADIAT ONCOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. RP McCarthy, MJ (reprint author), WOMACK ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT BRAGG,NC, USA. NR 17 TC 9 Z9 10 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAY PY 1996 VL 109 IS 5 BP 1397 EP 1400 DI 10.1378/chest.109.5.1397 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UK625 UT WOS:A1996UK62500048 PM 8625698 ER PT J AU Wade, CE Dubick, MA Vassar, MJ Perry, CA Holcroft, JW AF Wade, CE Dubick, MA Vassar, MJ Perry, CA Holcroft, JW TI Plasma dextran concentrations in trauma patients administered hypertonic saline-dextran-70 SO CLINICAL CHEMISTRY LA English DT Letter ID 7.5-PERCENT NACL/6-PERCENT DEXTRAN-70; SMALL-VOLUME RESUSCITATION; HYPOTENSION; INFUSION; TRIAL; NACL C1 USA,INST SURG RES,MECH TRAUMA RES BRANCH,FT SAM HOUSTON,TX 78234. NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. UNIV CALIF DAVIS,DEPT SURG,DAVIS,CA 95616. NR 20 TC 5 Z9 5 U1 0 U2 2 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD MAY PY 1996 VL 42 IS 5 BP 779 EP 780 PG 2 WC Medical Laboratory Technology SC Medical Laboratory Technology GA UJ253 UT WOS:A1996UJ25300028 PM 8653912 ER PT J AU Cieslak, TJ Drabick, CJ Robb, ML AF Cieslak, TJ Drabick, CJ Robb, ML TI Pyogenic infections due to Ochrobactrum anthropi SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CDC GROUP-VD; NONFERMENTATIVE BACTERIA; IDENTIFICATION AB Ochrobactrum anthropi is a nonfermentative gram-negative bacillus that has been isolated with increasing frequency from human clinical specimens. Previously, its pathogenic niche was believed to involve the causation of catheter-associated bacteremic illnesses. We describe three cases of pyogenic infection due to O. anthropi, thereby expanding the known pathogenic potential of this organism. C1 WALTER REED ARMY MED CTR,DEPT CLIN MICROBIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP Cieslak, TJ (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 35 Z9 36 U1 1 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY PY 1996 VL 22 IS 5 BP 845 EP 847 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UH239 UT WOS:A1996UH23900018 PM 8722944 ER PT J AU Murphy, GS Echeverria, P Jackson, LR Arness, MK LeBron, C Pitarangsi, C AF Murphy, GS Echeverria, P Jackson, LR Arness, MK LeBron, C Pitarangsi, C TI Ciprofloxacin- and azithromycin-resistant Campylobacter causing traveler's diarrhea in US troops deployed to Thailand in 1994 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID FLUOROQUINOLONES C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NR 8 TC 48 Z9 49 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY PY 1996 VL 22 IS 5 BP 868 EP 869 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UH239 UT WOS:A1996UH23900032 PM 8722958 ER PT J AU Case, MP Lu, SCY AF Case, MP Lu, SCY TI Discourse model for collaborative design SO COMPUTER-AIDED DESIGN LA English DT Article DE agent; conflict; discourse design collaboration; concurrent engineering; blackboard architecture; KQML AB A Discourse Model, including a structure and a process, is developed that provides software support for collaborative engineering design. The model shares characteristics of other design systems in the literature, including frames, constraints, semantic networks, and libraries of sharable design objects. It contributes a new model for conflict-aware agents, dynamic identification and dissemination of agent interest sets, a virtual workspace language, automatic detection of conflict, and a unique protocol for negotiation that ensures that interested agents have an opportunity to participate. The model is implementation independent and applicable to many research and commercial design environments currently available. An example scenario is provided in the architecture/engineering/construction domain that illustrates collaboration during the conceptual design of a fire station. C1 UNIV ILLINOIS,KNOWLEDGE BASED ENGN SYST RES LAB,URBANA,IL 61801. RP Case, MP (reprint author), USA,CONSTRUCT ENGN RES LABS,POB 9005,CHAMPAIGN,IL 61821, USA. NR 15 TC 38 Z9 42 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0010-4485 J9 COMPUT AIDED DESIGN JI Comput.-Aided Des. PD MAY PY 1996 VL 28 IS 5 BP 333 EP 345 DI 10.1016/0010-4485(95)00053-4 PG 13 WC Computer Science, Software Engineering SC Computer Science GA UG376 UT WOS:A1996UG37600003 ER PT J AU English, JC Coots, NV AF English, JC Coots, NV TI A man with nevoid hyperkeratosis of the areola SO CUTIS LA English DT Article ID NIPPLE AB Nevoid hyperkeratosis of the nipple and areola is a unique clinical entity and a diagnosis of exclusion, The patient presenting with nipple/areolar hyperkeratosis must be examined carefully for other underlying cutaneous diseases such as epidermal nevi, ichthyosis, acanthosis nigricans, Darier's disease, cutaneous T-cell lymphoma, and other chronic skin dermatitides that may be responsible for the changes, If no other clinical findings are evident, the diagnosis can be made, Although the disorder is more common in women of childbearing age, men may show nevoid changes after estrogen therapy or idiopathically, The use of topical 12 percent lactic acid lotion (Lac-Hydrin(R)) resolves the skin changes over a six-month period. RP English, JC (reprint author), BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,BLDG 3600,3851 ROGER BROOKE DR,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 18 Z9 18 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD MAY PY 1996 VL 57 IS 5 BP 354 EP 356 PG 3 WC Dermatology SC Dermatology GA UM093 UT WOS:A1996UM09300015 PM 8726719 ER PT J AU Winger, G Woods, JH Hursh, SR AF Winger, G Woods, JH Hursh, SR TI Behavior maintained by alfentanil or nalbuphine in rhesus monkeys: Fixed-ratio and time-out changes to establish demand curves and relative reinforcing effectiveness SO EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY LA English DT Article ID ECONOMICS AB A fixed-ratio, time-out schedule of intravenous alfentanil or nalbuphine delivery was used to maintain responding in rhesus monkeys (Macaca mulatta) during twice-daily 2-hr sessions of unrestricted access. Four doses of each drug were tested under 10 response fixed-ratio and 10-s time-out baseline conditions. Either the fixed ratio or the time-out was periodically increased during single sessions. Alfentanil maintained higher response rates than nalbuphine under conditions in which response rates were limited by the size of the fixed ratio rather than by unconditioned effects. This indicates that alfentanil is a more effective reinforcer than nalbuphine, which is predicted on the basis of the greater intrinsic efficacy of alfentanil relative to nalbuphine at the mu opioid receptor. Unit price analysis of these data demonstrated that a single demand function could be drawn for each drug, indicating that for these opioids in this situation, increasing the dose per injection was equivalent to decreasing the fixed ratio. C1 UNIV MICHIGAN,DEPT PSYCHOL,ANN ARBOR,MI. WALTER REED ARMY INST RES,WASHINGTON,DC. RP Winger, G (reprint author), UNIV MICHIGAN,DEPT PHARMACOL,1301 MED SCI RES BLDG 3,ANN ARBOR,MI 48109, USA. NR 16 TC 23 Z9 23 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 1064-1297 J9 EXP CLIN PSYCHOPHARM JI Exp. Clin. Psychopharmacol. PD MAY PY 1996 VL 4 IS 2 BP 131 EP 140 DI 10.1037/1064-1297.4.2.131 PG 10 WC Psychology, Biological; Psychology, Clinical; Pharmacology & Pharmacy; Psychiatry SC Psychology; Pharmacology & Pharmacy; Psychiatry GA UM795 UT WOS:A1996UM79500001 ER PT J AU Kim, HJ Choi, YM Yang, TCS Taub, IA Tempest, P Skudder, P Tucker, G Parrott, DL AF Kim, HJ Choi, YM Yang, TCS Taub, IA Tempest, P Skudder, P Tucker, G Parrott, DL TI Validation of ohmic heating for quality enhancement of food products SO FOOD TECHNOLOGY LA English DT Article; Proceedings Paper CT IFT Biotechnology Symposium on Food Allergy, at the Annual Meeting of the Institute-of-Food-Technologists CY JUN 03-07, 1995 CL ANAHEIM, CA SP Inst Food Technologists ID RESIDENCE TIME DISTRIBUTION; PARTICULATE FOODS; PARTICLES; FLOW; SUSPENSIONS; SYSTEMS AB Volumetric heating and near plug flow make ohmic heating a promising aseptic processing technology for military rations and commercial shelf-stable food products C1 APV BAKER LTD,CRAWLEY RH10 2QB,W SUSSEX,ENGLAND. CAMPDEN & CHORLEYWOOD FOOD RES ASSOC,CHIPPING CAMPDEN GL55 6LD,GLOS,ENGLAND. APV CREPACO INC,TONAWANDA,NY 14150. RP Kim, HJ (reprint author), USA,NATICK RES,CTR DEV & ENGN,SOLDIER SYST COMMAND,NATICK,MA 01760, USA. NR 28 TC 51 Z9 52 U1 0 U2 1 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0015-6639 J9 FOOD TECHNOL-CHICAGO JI Food Technol. PD MAY PY 1996 VL 50 IS 5 BP 253 EP & PG 8 WC Food Science & Technology SC Food Science & Technology GA UN005 UT WOS:A1996UN00500038 ER PT J AU Sherer, SW Kouchakdjian, A Arnold, PG AF Sherer, SW Kouchakdjian, A Arnold, PG TI Experience using cleanroom software engineering SO IEEE SOFTWARE LA English DT Article AB The US Department of Defense spends the largest portion of its software budget on reengineering and maintenance. The project profiled in this article, the US Army's first attempt to improve these processes using Cleanroom methods, resulted in greater productivity, improved job satisfaction, and a high return on investment. C1 CARNEGIE MELLON UNIV,INST SOFTWARE ENGN,PITTSBURGH,PA 15213. SOFTWARE ENGN TECHNOL INC,STARS PROGRAM,KNOXVILLE,TN. RP Sherer, SW (reprint author), USA,ARDEC AMSTA AR FSF S,TACOM LIFE CYCLE SOFTWARE ENGN CTR,BLDG 352,PICATINNY ARSENAL,NJ 07806, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0740-7459 J9 IEEE SOFTWARE JI IEEE Softw. PD MAY PY 1996 VL 13 IS 3 BP 69 EP & DI 10.1109/52.493022 PG 9 WC Computer Science, Software Engineering SC Computer Science GA UH514 UT WOS:A1996UH51400018 ER PT J AU Narayanan, RM Cox, DD Ralston, JM Christian, MR AF Narayanan, RM Cox, DD Ralston, JM Christian, MR TI Millimeter-wave specular and diffuse multipath components of terrain SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article ID TRACKING AB Multipath interference data were obtained at a frequency of 95 GHz over pathlengths of 100-250 m by measuring height-gain interference patterns over various types of terrain, Data were collected over grass, lake, ice, snow, concrete, asphalt, and gravel surfaces. The transmit antenna was kept fixed, while the receive antenna translated vertically resulting in grazing angles between approximately 0.5-2.0 degrees, Full illumination of the Fresnel zones was accomplished by broad-beamwidth horn antennas at both ends, Measured interference patterns indicate the presence of both specular and diffuse multipath components. A technique was developed to separate these components by filtering in the spatial Fourier-transform domain by appropriate choice of the notch frequency for the specular component and the bandpass-filter bandwidth for the diffuse components, The notch frequency is chosen according to system geometry considerations, Using this unique separation technique, specular and diffuse reflection coefficients were deduced for various terrain types. The separation technique developed in this paper can be readily applied to existing height-gain data if the system geometry is known. C1 INST DEF ANAL,ALEXANDRIA,VA 22311. USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP Narayanan, RM (reprint author), UNIV NEBRASKA,DEPT ELECT ENGN,CTR ELECTROOPT,LINCOLN,NE 68588, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 1996 VL 44 IS 5 BP 627 EP 645 DI 10.1109/8.496248 PG 19 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA UJ956 UT WOS:A1996UJ95600005 ER PT J AU Tobias, JM AF Tobias, JM TI Testing of ground conductors with artificially generated lightning current SO IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS LA English DT Article AB Alternative conductors for lightning protection applications favorable for use in mobile systems have been tested to demonstrate high levels of protection against maximal lightning events. The method of determining the survivability of the down conductors was to expose each type of conductor to maximal lightning events generated by a large Marx capacitor bank. Each type of conductor was tested until mechanical failure occurred or until it survived four exposures to the lightning event. A test to determine the effect of physical damage on conductor performance was also conducted. A theory attributing interstrand or intraconductor magnetic forces, rather than ohmic heating, as the primary cause of conductor failure is proposed. Results indicate that two types of tested conductor exist which can pro,ide protection against maximal lightning events, yet have properties that lend themselves to mobile application. RP Tobias, JM (reprint author), USA,CECOM,FT MONMOUTH,NJ 07703, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-9994 J9 IEEE T IND APPL JI IEEE Trans. Ind. Appl. PD MAY-JUN PY 1996 VL 32 IS 3 BP 594 EP 598 DI 10.1109/28.502171 PG 5 WC Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Engineering GA UM675 UT WOS:A1996UM67500013 ER PT J AU Nuteson, TW Monahan, GP Steer, MB Naishadham, K Mink, JW Kojucharow, KK Harvey, J AF Nuteson, TW Monahan, GP Steer, MB Naishadham, K Mink, JW Kojucharow, KK Harvey, J TI Full-wave analysis of quasi-optical structures SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB A full-wave moment method implementation, using a combination of spatial and spectral domains, is developed for the analysis of quasi-optical systems. An electric field dyadic Green's function, including resonant and nonresonant terms corresponding to coupling from modal and nonmodal fields, is employed in a Galerkin routine. The dyadic Green's function is derived by separately considering paraxial and nonparaxial fields and is much easier to develop than a mixed, scalar and vector, potential Green's function. The driving point impedance of several antenna elements in a quasi-optical open cavity resonator and a 3 x 3 grid in free space are computed and compared with measurements. C1 WRIGHT STATE UNIV,DEPT ELECT ENGN,DAYTON,OH 45435. DRESDEN UNIV TECHNOL,DEPT ELECT & COMP ENGN,O-8027 DRESDEN,GERMANY. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Nuteson, TW (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,ELECTR RES LAB,RALEIGH,NC 27695, USA. NR 15 TC 7 Z9 7 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAY PY 1996 VL 44 IS 5 BP 701 EP 710 DI 10.1109/22.493923 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA UL099 UT WOS:A1996UL09900008 ER PT J AU Lanar, DE Tine, JA DeTaisne, C Seguin, MC Cox, WI Winslow, JP Ware, LA Kauffman, EB Gordon, D Ballou, WR Paoletti, E Sadoff, JC AF Lanar, DE Tine, JA DeTaisne, C Seguin, MC Cox, WI Winslow, JP Ware, LA Kauffman, EB Gordon, D Ballou, WR Paoletti, E Sadoff, JC TI Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria SO INFECTION AND IMMUNITY LA English DT Article ID GENETICALLY ENGINEERED POXVIRUSES; LETHAL JEV INFECTION; TOXIC LYMPHOCYTES-T; PLASMODIUM-BERGHEI; BIOLOGICAL-ACTIVITY; ORAL SALMONELLA; IMMUNE-RESPONSE; SURFACE-ANTIGEN; GLYCOPROTEIN-D; ENVELOPE GENE AB NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vivo CD8(+) T-cell depletion. Protection was not enhanced by modification of the subcellular localization of CSP. These results suggest the potential of poxvirus-based vectors for the development of vaccine candidates for human malaria. C1 VIROGENET CORP,TROY,NY 12180. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. PASTEUR MERIEUX SERUMS & VACCINS,F-69280 MARCY LETOILE,FRANCE. RI Lanar, David/B-3560-2011 NR 59 TC 40 Z9 41 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1996 VL 64 IS 5 BP 1666 EP 1671 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UG365 UT WOS:A1996UG36500025 PM 8613376 ER PT J AU Lowell, GH Kaminski, RW Grate, S Hunt, RE Charney, C Zimmer, S Colleton, C AF Lowell, GH Kaminski, RW Grate, S Hunt, RE Charney, C Zimmer, S Colleton, C TI Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: Immunogenicity and efficacy against lethal SEB intoxication in mice SO INFECTION AND IMMUNITY LA English DT Article ID CHOLERA-TOXIN; BIODEGRADABLE MICROSPHERES; ANTIBODY-RESPONSES; MUCOSAL IMMUNITY; PROTEIN ANTIGEN; IMMUNIZATION; SUBUNIT; ADJUVANTS; SHOCK; LIPOSOMES AB Intranasal or intramuscular (i.m.) immunization of mice and i.m. immunization of rabbits with formalinized staphylococcal enterotoxin B (SEB) toroid in saline elicited higher anti-SEB serum immunoglobulin G (IgG) titers when the toxoid was formulated with proteosomes. In addition, intranasal immunization of mice with this proteosome-toxoid vaccine elicited high levels of anti-SEB IgA in lung and intestinal secretions, whereas the toxoid without proteosomes did not. Two i.m. immunizations with proteosome-toxoid plus alum also induced higher murine serum responses than alum-adjuvanted toxoid without proteosomes. Furthermore, proteosome-toxoid delivered intranasally in saline or i.m. with either saline or alum afforded significant protection against lethal SEB challenge in two D-galactosamine-sensitized murine models of SEB intoxication, i.e., the previously described i.m. challenge model and a new respiratory challenge model of mucosal SEB exposure, Efficacy correlated with the induction of high serum levels of anti-SEB IgG. In contrast, intranasal or i.m. immunization with toxoid in saline without proteosomes was not significantly protective in either challenge model. Proteosome-toxoid plus alum given i.m. also elicited more significant protection against respiratory challenge than the alum-adjuvanted toroid alone. The capacity of proteosomes to enhance both i.m. and intranasal immunogenicity and efficacy of SEB toxoid indicates that testing such proteosome-SEB toxoid vaccines in the nonhuman primate aerosol challenge model of SEB intoxication prior to immunogenicity trials in humans is warranted. These data expand the applicability of the proteosome mucosal vaccine delivery system to protein toxoids and suggest that respiratory delivery of proteosome vaccines may be practical for enhancement of both mucosal and systemic immunity against toxic or infectious diseases. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. PHARMOS CORP,ALACHUA,FL 32702. NR 53 TC 43 Z9 45 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1996 VL 64 IS 5 BP 1706 EP 1713 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UG365 UT WOS:A1996UG36500030 PM 8613381 ER PT J AU Revelle, C Schweitzer, J Snyder, S AF Revelle, C Schweitzer, J Snyder, S TI The maximal conditional covering problem SO INFOR LA English DT Article ID GREEDY HEURISTICS; LOCATION; FACILITIES AB This paper formulates and solves three new problems in the location coverage literature. Two of the formulations are variations of a problem which we term the Maximal Conditional Covering Problem (MCCP I and II), and the third we term the Multiobjective Conditional Covering Problem (MOCCP). The MCCP and the MOCCP are extensions of the Conditional Covering Problem, and draw upon the well-studied Location Set Covering Problem and the Maximal Covering Location Problem. The MCCP problem seeks to site servers in such a way as to maximize the number of servers which are themselves covered by another server. At the same time, primary coverage by servers is provided for all demand nodes subject to a constraint on the number of servers in the system. The MOCCP problem trades off population with primary coverage against the number of servers with supporting coverage. The models are formulated as linear zero-one programs; examples are solved as relaxed linear programs with modest branching and bounding to achieve all zero-one solutions. The models have applications to a variety of location coverage systems in which supporting coverage of servers is required, including emergency medical services, fire equipment services, and police squad car coverage. C1 COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027. RP Revelle, C (reprint author), JOHNS HOPKINS UNIV,DEPT GEOG & ENVIRONM ENGN,313 AMES HALL,BALTIMORE,MD 21218, USA. NR 11 TC 12 Z9 12 U1 0 U2 3 PU INFOR PI DOWNSVIEW ONTARIO PA UNIV TORONTO PRESS, JOURNALS DEPT,5201 DUFFERIN ST, DOWNSVIEW ONTARIO TORONTO M3H 5T8, CANADA SN 0315-5986 J9 INFOR JI Infor PD MAY PY 1996 VL 34 IS 2 BP 77 EP 91 PG 15 WC Computer Science, Information Systems; Operations Research & Management Science SC Computer Science; Operations Research & Management Science GA UN552 UT WOS:A1996UN55200002 ER PT J AU Shparago, N Zelazowski, P Jin, L McIntyre, TM Stuber, E Pecanha, LMT Kehry, MR Mond, JJ Max, EE Snapper, CM AF Shparago, N Zelazowski, P Jin, L McIntyre, TM Stuber, E Pecanha, LMT Kehry, MR Mond, JJ Max, EE Snapper, CM TI IL-10 selectively regulates murine Ig isotype switching SO INTERNATIONAL IMMUNOLOGY LA English DT Article DE anti-Ig-dextran; CD40; CD40 ligand; digestion-circularization PCR; IL-4; IL-5; lipopolysaccharide; transforming growth factor-beta ID HUMAN B-CELLS; CYTOKINE PRODUCTION; IMMUNOGLOBULIN-A; LYMPHOCYTES-B; INTERLEUKIN-10; TRANSCRIPTS; ANTIBODY; GROWTH; RECOMBINATION; EXPRESSION AB A role for IL-10 in regulating Ig isotype switching directly at the level of the murine B cell has not been previously reported, In this report we show that IL-10 selectively up-regulated IgM to IgG3 class switching in lipopolysaccharide (LPS)-activated cultures through a direct effect on membrane (m) IgM(+)IgG3(-) B cells in vitro. IL-10 stimulated a 3- to 4-fold enhancement (from 6-8 to 20-30%) in membrane mIgG3(+) cells and a significant increase in S-mu-S(gamma)3 DNA rearrangement events as measured by digestion-circularization PCR (DC-PCR) over that observed with LPS alone, IL-10 induction of switching to lgG3 was not accompanied by a corresponding increase in the steady-state levels of germline C(H gamma)3 RNA, By contrast, IL-10 strongly inhibited the transforming growth factor-beta-mediated generation of mIgA(+) cells and S-mu-S-alpha DNA rearrangement events in LPS-, but not CD40 ligand (CD40L)-activated B cells, This effect was not accompanied by changes in the steady-state levels of germline C-H alpha RNA. IL-10 had no effect on IL-4-mediated switching to either IgG1 or IgE in either LPS- or CD40L-activated B cells, Thus, IL-10 can either enhance or suppress switching to particular murine Ig isotypes but it differs from most other murine cytokines in that its effects on switching do not appear to be associated with changes in the corresponding steady-state levels of germline C-H RNA. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,CLIN INVEST LAB,BETHESDA,MD 20892. US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. IM UFRJ,DEPTO IMUNOL,RIO JANEIRO,BRAZIL. BOEHRINGER INGELHEIM PHARMACEUT INC,RIDGEFIELD,CT 06877. FU NIAID NIH HHS [AI32560, AI36588] NR 40 TC 35 Z9 35 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0953-8178 J9 INT IMMUNOL JI Int. Immunol. PD MAY PY 1996 VL 8 IS 5 BP 781 EP 790 DI 10.1093/intimm/8.5.781 PG 10 WC Immunology SC Immunology GA UN188 UT WOS:A1996UN18800018 PM 8671667 ER PT J AU Blank, S AF Blank, S TI Central Asia's international relations in the Asian context SO ISSUES & STUDIES LA English DT Review DE Russia; Central Asia; India; Pakistan; PRC AB Most analysts of Central Asia's international relations assume that Russia dominates the scene and faces Muslim rivalry from Turkey and Iran. While Russia is the single largest international factor in the region and has sought to dominate it through coercive diplomacy, such an analysis overlooks the crucial Asian dimension of Central Asia's international relations. A closer look at the region shows that Russia is encountering difficulties and cannot sustain its neo- imperialist policies. Central Asian states can now turn to India or Pakistan as well as the People's Republic of China (PRC) and the United States for help. The United States has blocked Russian spheres of influence in energy policy and is generally limiting Russian influence there. India and Pakistan have been attempting also, with partial success thus far, to utilize the area in their rivalry, which has enhanced Central Asia's opportunity for trade and improving relations. Nevertheless, the single greatest potential rival to Russia will probably be the PRC. The PRC has been driven by its energy needs and fear of Islamic self-assertion to devise a sophisticated policy toward Muslims and Central Asia and could well emerge as Russia's rival. As a result, the Asian dimension of Central Asia's international affairs has now become one of great-power rivalry. RP Blank, S (reprint author), USA,WAR COLL,STRATEG STUDIES INST,CARLISLE,PA, USA. NR 120 TC 0 Z9 0 U1 0 U2 2 PU INST INTERNAT RELATIONS PI MUCHA PA 64 WAN SHOU ROAD, MUCHA, TAIPEI, TAIWAN SN 1013-2511 J9 ISSUES STUD JI Issues Stud. PD MAY PY 1996 VL 32 IS 5 BP 96 EP 124 PG 29 WC Area Studies; International Relations; Political Science SC Area Studies; International Relations; Government & Law GA UT021 UT WOS:A1996UT02100006 ER PT J AU Dubey, M Jones, KA Han, WY West, LC Roberts, CW Dunkel, JP Peticolas, L Bean, JC AF Dubey, M Jones, KA Han, WY West, LC Roberts, CW Dunkel, JP Peticolas, L Bean, JC TI Infrared absorption of Ge epitaxial films on a GaAs substrate SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SPECTROSCOPY AB Germanium films were deposited on GaAs (100) substrates with or without an epiready surface oxide at temperatures between room temperature (RT) and 500 degrees C using an ultrahigh-vacuum e-beam deposition system. The film at 100 degrees C on a substrate with a surface oxide had a flat absorption curve over the wave-number range investigated, 500-4000 cm(-1), with an absorption of less than 10/cm at 1000 cm(-1) (10 mu m wavelength). Films deposited at RT and 50 degrees C on substrates with a surface oxide had comparable low absorption, but they contained an absorption peak at 830 cm(-1) associated with the Ge-O bonds. Although all three films were amorphous, the films deposited at the lower temperatures were more porous. This enabled oxygen to percolate in from the atmosphere to form the Ge-O bonds. The films deposited at 150 degrees C and above on substrates with a surface oxide and at 100 degrees C with the surface oxide removed thermally in situ prior to deposition the Ge films, and the single crystal films deposited at 400 and 500 degrees C on oxide-free substrates, had strong absorption in the vicinity of the Ge/GaAs interface with the characteristic of two-dimensional free-carrier absorption. (C) 1996 American Institute of Physics. C1 AT&T BELL LABS,HOLMDEL,NJ 07733. RP Dubey, M (reprint author), USA,RES LAB,PSD,FT MONMOUTH,NJ 07703, USA. NR 11 TC 5 Z9 5 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1996 VL 79 IS 9 BP 7157 EP 7160 DI 10.1063/1.361486 PG 4 WC Physics, Applied SC Physics GA UJ084 UT WOS:A1996UJ08400071 ER PT J AU Shitzer, A Stroschein, LA Gonzalez, RR Pandolf, KB AF Shitzer, A Stroschein, LA Gonzalez, RR Pandolf, KB TI Lumped-parameter tissue temperature blood perfusion model of a cold-stressed fingertip SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE cold environment; skin temperature; cold-induced vasodilatation AB A lumped-parameter model of a fingertip is presented. The semispherical model includes the effects of heat storage, heat exchange with the environment, and heat transport by blood perfusion. The thermal insulation on the surface of the fingertip is represented by the overall heat transfer coefficient that is calculated by common engineering formulas. The model is solved analytically for the simple case of constant blood perfusion rate. The general case of variable blood perfusion rates is solved by an Euler finite difference technique. At this stage, the model does not include active control mechanisms of blood perfusion. Thus the effects of cold-induced vasodilatation have to be superimposed and are modeled by symmetrical triangular waveforms because these were found to best depict the behavior of fingers exposed to cold environments. Results of this model were compared with experimental data obtained in two separate studies. One included 60-min infrared thermograms of the dorsal surface of bare hands of sedentary subjects horizontally suspended on a fish net in a 0 degrees C environment. Another study, on gloved finger temperatures, involved 0 and -6.7 degrees C environments. Fingertip (nail bed) temperatures of both these studies were compared with model predictions. Blood perfusion rates were assumed and adjusted within physiologically reasonable limits. Comparison of measured and computed temperature records showed very good conformity in both cases studied. C1 USA,ENVIRONM MED RES INST,ENVIRONM PHYSIOL & MED DIRECTORATE,BIOPHYS & BIOMED MODELING DIV,NATICK,MA 01760. RP Shitzer, A (reprint author), TECHNION ISRAEL INST TECHNOL,DEPT MECH ENGN,IL-32000 HAIFA,ISRAEL. NR 22 TC 21 Z9 21 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 1996 VL 80 IS 5 BP 1829 EP 1834 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA UM254 UT WOS:A1996UM25400050 PM 8727573 ER PT J AU Cooper, JR Caldwell, DJ AF Cooper, JR Caldwell, DJ TI Teratologic evaluation of liquid propellant (XM46) in the rat SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE teratology; rat; propellant; XM46 AB The Army has proposed using a liquid propellant (XM46) composed of hydroxylammonium nitrate (HAN) and triethanolammonium nitrate (TEAN) in its Advanced Field Artillery System, This study was undertaken to determine the potential threat to the unborn fetus should female Army personnel become exposed to this compound during pregnancy, Timed pregnant rats (Crl:CD(R) Charles River Laboratories, Inc.) were purchased on day 4 of pregnancy and divided into a control and four dose groups of 25-28 animals each, Animals were dosed orally with XM46 on days 6-15 of pregnancy at the rate of 0.0, 162.5, 325 and 650 mg kg(-1) body wt day(-1), Cesarean section was performed on gestation day 20. Maternal body weight was significantly reduced in the 650 mg kg(-1) day(-1) dose group on days 5-20 of pregnancy, Likewise, maternal food consumption was significantly reduced in the high-dose animals during the dosing period. There were no exposure-related differences in fetal weight, number, sex or frequency of malformations observed in fetuses between control and treated dams, The results of this study indicate that XM46 is not a teratogen in the rat. C1 USA,OCCUPAT HLTH RES DETACHMENT,WRIGHT PATTERSON AFB,OH 45433. RP Cooper, JR (reprint author), ARMSTRONG LAB,COMPARAT MED BRANCH,WRIGHT PATTERSON AFB,OH 45433, USA. NR 17 TC 1 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY-JUN PY 1996 VL 16 IS 3 BP 277 EP 280 PG 4 WC Toxicology SC Toxicology GA UW503 UT WOS:A1996UW50300015 PM 8818871 ER PT J AU Dalsgaard, A Mortensen, HF Molbak, K Dias, F Serichantalergs, O Echeverria, P AF Dalsgaard, A Mortensen, HF Molbak, K Dias, F Serichantalergs, O Echeverria, P TI Molecular characterization of Vibrio cholerae O1 strains isolated during cholera outbreaks in Guinea-Bissau SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID TOXIN GENES; THAILAND; PLASMID; DNA; RESISTANCE; EPIDEMIC AB In the present study, 19 strains of Vibrio cholerae O1 biotype El Tor isolated during outbreaks of cholera in Guinea Bissau in 1987, 1994, and 1995 were characterized to investigate a possible epidemiological relationship among the isolates. On the basis of ribotyping with the restriction enzyme BglI, 5 strains isolated in 1987 showed two closely related ribotypes, while 14 strains isolated in 1994 and 1995 showed the same ribotype that was distinct from the ribotypes of strains isolated in 1987, Southern blot hybridization of BglI-digested genomic DNA with a cholera toxin probe demonstrated that the strains isolated in 1987 shelved an identical cholera toxin genotype, whereas O1 strains isolated in 1994 and 1995 showed the same genotype that was distinct from the genotype of strains isolated in 1987, These results were supported by the results of antibiotic susceptibility testing, in which strains isolated in 1987 showed resistance to polymyxin B only, while each of the strains from 1994 and 1995 showed resistance to polymyxin B, trimethoprim-sulfamethoxazole, and the vibriostatic agent O/129, Although our results are based on a limited number of V. cholerae O1 strains, they suggest that the epidemic in Guinea-Bissau in 1994 and 1995 was due to the introduction of a new strain to the country. C1 PROJECTO SAUDE,BANDIM,GUINEA BISSAU. STATENS SERUMINST,DANISH EPIDEMIOL SCI CTR,COPENHAGEN,DENMARK. LAB NACL SAUDE PUBL,BISSAU,GUINEA BISSAU. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP Dalsgaard, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK. RI Skall, Helle/B-1180-2014 OI Skall, Helle/0000-0002-9489-1419 NR 34 TC 33 Z9 34 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1996 VL 34 IS 5 BP 1189 EP 1192 PG 4 WC Microbiology SC Microbiology GA UF570 UT WOS:A1996UF57000029 PM 8727901 ER PT J AU Perloff, M Norton, L Korzun, AH Wood, WC Carey, RW Gottlieb, A Aust, JC Bank, A Silver, RT Saleh, F Canellos, GP Perry, MC Weiss, RB Holland, JF AF Perloff, M Norton, L Korzun, AH Wood, WC Carey, RW Gottlieb, A Aust, JC Bank, A Silver, RT Saleh, F Canellos, GP Perry, MC Weiss, RB Holland, JF TI Postsurgical adjuvant chemotherapy of stage II breast carcinoma with or without crossover to a non-cross-resistant regimen: A cancer and leukemia group B study SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID RANDOMIZED TRIAL; THERAPY; METHOTREXATE; SENSITIVITY; ADRIAMYCIN; MODELS AB Purpose: To compare two cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP) regimens with a doxorubicin-based regimen-vinblastine, doxorubicin, thiotepa, and Halotestin (Upjohn, Kalamazoo, MI) (VATH)-in patients with stage II node-positive breast carcinoma. Methods: Nine hundred forty-five women were treated with a 6-week induction course of CMFVP. They were then randomized to receive one of two consolidation CMFVP regimens: 6-week courses or 2-week courses. Following completion of CMFVP consolidation, patients were again randomized to either continue the CMFVP regimen or to receive six escalating doses of VATH. Results: Among all patients, with a median follow-up time of 11.5 years, there is no statistically significant difference in disease-free survival (DFS) between the two consolidation CMFVP regimens, VATH intensification treatment is statistically significantly superior to CMFVP in terms of DFS (P = .0040), For patients with one to three involved nodes, there is currently no significant difference between VATH and CMFVP; however, among those with four or more positive lymph nodes, there is a significant difference in favor of VATH (P = .0037). There is also improved overall survival with VATH (P = .043; median, > 14 years v 10 years), This difference is also statistically significant in patients with four or more involved lymph nodes, among postmenopausal patients, and among postmenopausal estrogen receptor-positive patients. Conclusion: Chemotherapy with crossover to escalating dose of VATH following CMFVP was well tolerated and effective, Inauguration of VATH as a treatment intensification at the eighth month produced a major increase in relapse-free and overall survival, The observation that sensitivity to VATH is retained 50 long after mastectomy raises questions about the proper duration of adjuvant chemotherapy and lends support to further investigation of crossover designs in future trials of postoperative adjuvant chemotherapy regimens. (C) 1996 by American Society of Clinical Oncology. C1 NCI,BETHESDA,MD 20892. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. COLUMBIA PRESBYTERIAN MED CTR,NEW YORK,NY. NEW YORK HOSP,CORNELL MED CTR,NEW YORK,NY 10021. MT SINAI HOSP,NEW YORK,NY 10029. SUNY SYRACUSE,HLTH SCI CTR,SYRACUSE,NY 13210. EMORY UNIV,SCH MED,ATLANTA,GA 30322. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. DANA FARBER CANC INST,BOSTON,MA 02115. ONCOL ASSOCIATES SAN DIEGO,SAN DIEGO,CA. UNIV MISSOURI,ELLIS FISCHEL CANC CTR,COLUMBIA,MO. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FU NCI NIH HHS [CA12449, CA07968, CA33601] NR 30 TC 49 Z9 49 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY PY 1996 VL 14 IS 5 BP 1589 EP 1598 PG 10 WC Oncology SC Oncology GA UJ403 UT WOS:A1996UJ40300025 PM 8622076 ER PT J AU VadhanRaj, S Burris, H Benjamin, RS Patel, S Johnston, T Hellmann, S Cohen, R Watanabe, B VonHoff, D AF VadhanRaj, S Burris, H Benjamin, RS Patel, S Johnston, T Hellmann, S Cohen, R Watanabe, B VonHoff, D TI Single-dose therapy with recombinant human thrombopoietin (rhTPO) in patients receiving cytotoxic chemotherapy. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 UNIV TEXAS,MD ANDERSON CANC CTR,HOUSTON,TX. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,SAN ANTONIO,TX. GENENTECH INC,S SAN FRANCISCO,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY PY 1996 VL 14 IS 5 BP 2010 EP 2010 PG 1 WC Oncology SC Oncology GA UJ403 UT WOS:A1996UJ40300061 ER PT J AU Pearton, SJ Shul, RJ Wilson, RG Ren, F Zavada, JM Abernathy, CR Vartuli, CB Lee, JW Mileham, JR Mackenzie, JD AF Pearton, SJ Shul, RJ Wilson, RG Ren, F Zavada, JM Abernathy, CR Vartuli, CB Lee, JW Mileham, JR Mackenzie, JD TI The incorporation of hydrogen into III-V nitrides during processing SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Electronic Materials Conference CY JUN 21-23, 1995 CL CHARLOTTESVILLE, VA DE III-V nitrides; defects; hydrogen; passivation; shallow donors AB Hydrogen is readily incorporated into GaN and related alloys during wet and dry etching, chemical vapor deposition of dielectric overlayers, boiling in water, and other process steps, in addition to its effects during metalorganic chemical vapor deposition or metalorganic molecular beam epitaxial growth. The hydrogen is bound at defects or impurities and passivates their electrical activity. Reactivation of passivated shallow donors in the nitrides occurs at 450-550 degrees C, but evolution from the crystal requires much higher temperatures (greater than or equal to 800 degrees C for GaN). C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. HUGHES RES LABS,MALIBU,CA 90265. AT&T BELL LABS,MURRAY HILL,NJ 07974. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Pearton, SJ (reprint author), UNIV FLORIDA,GAINESVILLE,FL 32611, USA. NR 9 TC 23 Z9 23 U1 0 U2 3 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD MAY PY 1996 VL 25 IS 5 BP 845 EP 849 DI 10.1007/BF02666647 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA UJ099 UT WOS:A1996UJ09900013 ER PT J AU Zirschky, J AF Zirschky, J TI Take-home toxin pathway SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Review ID PROTECTIVE APPAREL FABRICS; METHYL PARATHION; OCCUPATIONAL EXPOSURE; MALIGNANT MESOTHELIOMA; CONTAMINATED FABRICS; ASBESTOS; WORKERS; REMOVAL; CHILDREN; LEAD AB Each year, American families are exposed to toxic substances brought home on the work clothes of other family members. Case studies show that illness and death have resulted and that small amounts of contamination can create an unsafe environment in the home. In this paper, the available data on the transport pathway for workplace chemicals into the home are reviewed. A model to describe contaminant accumulation in the home is proposed. The half-life for some contaminants in the home appears to be on the order of months instead of years. RP Zirschky, J (reprint author), USA,CIV WORKS,108 ARMY PENTAGON,WASHINGTON,DC 20310, USA. NR 110 TC 4 Z9 4 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD MAY PY 1996 VL 122 IS 5 BP 430 EP 436 DI 10.1061/(ASCE)0733-9372(1996)122:5(430) PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA UG902 UT WOS:A1996UG90200015 ER PT J AU Crum, D AF Crum, D TI Reliability applied to slope stability analysis SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Editorial Material RP Crum, D (reprint author), USA,CORPS ENGINEERS,ST PAUL,MN 55101, USA. NR 0 TC 3 Z9 3 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD MAY PY 1996 VL 122 IS 5 BP 417 EP 417 DI 10.1061/(ASCE)0733-9410(1996)122:5(417) PG 1 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA UG903 UT WOS:A1996UG90300016 ER PT J AU White, KL Snyder, HL Krzych, U AF White, KL Snyder, HL Krzych, U TI MHC class I-dependent presentation of exoerythrocytic antigens to CD8(+) T lymphocytes is required for protective immunity against Plasmodium berghei SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; DEFICIENT MICE; BETA-2-MICROGLOBULIN-DEFICIENT MICE; MALARIA SPOROZOITES; CELLS RECOGNIZE; IFN-GAMMA; INFECTION; YOELII; IMMUNOGENICITY; SUSCEPTIBILITY AB T lymphocytes are believed to play a major role in protection against malaria. Previous experiments using in vivo depletion of CD8(+) T cells, reconstitution with CD8(+) T splenic cells, and adoptive transfer of CD8(+) CTL clones demonstrated that protection against the exoerythrocytic stage of the murine strain, Plasmodium berghei malaria, was CD8(+) T cell-dependent, Despite evidence for the critical role of CD8(+) CTL, neither the cellular nor the molecular requirements for CD8(+) T cell induction or for recognition of malaria Ags are known, In this study, we wished to define the role of CD8(+) T cells and MHC class I molecules by using the P. berghei malaria attenuated sporozoites (SPZ) protection model in beta(2)-microglobulin (beta(2)m) knockout (-/-) mice, In contrast to observations that beta(2)m(-/-) mice are resistant to many infectious diseases by compensatory mechanisms involving non-class I-restricted T cells, we found that beta 2m(-/-) mice failed to be protected against P. berghei SPZ, although immunization with attenuated SPZ induced production of IL-2, INF-gamma, anti-circumsporozoite protein IgG, and proliferative T cells, The lack of compensatory mechanisms involving non-CD8(+) T cells was particularly evident in the failure to adoptively transfer protective immunity with wild-type SPZ-immune splenic T cells, From our data it can be concluded that CD8(+) T cells induced during immunization with attenuated SPZ must recognize liver-expressed Ags presented by class I molecules to engage effectively in a response leading to destruction of the malaria parasites. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064. NR 49 TC 54 Z9 54 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 1996 VL 156 IS 9 BP 3374 EP 3381 PG 8 WC Immunology SC Immunology GA UF742 UT WOS:A1996UF74200037 PM 8617963 ER PT J AU Skillman, DR Malone, JL Decker, CF Wagner, KF Mapou, RL Liao, MJ Testa, D Meltzer, MS AF Skillman, DR Malone, JL Decker, CF Wagner, KF Mapou, RL Liao, MJ Testa, D Meltzer, MS TI Phase I trial of interferon alfa-n3 in early-stage human immunodeficiency virus type 1 disease: Evidence for drug safety, tolerance, and antiviral activity SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID KAPOSIS-SARCOMA; ALPHA-INTERFERON; HIV-INFECTION; SYNDROME AIDS; NEUTRALIZING ANTIBODIES; CANCER-PATIENTS; MX PROTEIN; THERAPY; REPLICATION; EXPRESSION AB The safety and tolerance of interferon alfa-n3 (IFN-alpha n3) was tested in 20 adults with asymptomatic human immunodeficiency virus type 1 (HIV-1) infection (>400 CD4 lymphocytes/mm(3)). IFN-alpha n3 was self-injected three times per week for 3-6 months: 5 patients received 1 mega-IU (MIU)/dose, 10 received 5 MIU/dose, and 5 escalated to their maximum tolerated dose, Subjects were evaluated every 2-4 weeks through 2 months after cessation of treatment, Neuropsychological tests were given at 3-month intervals, Markers of IFN activity, anti-IFN neutralizing antibodies, and antiviral response were measured monthly, IFN-alpha n3 was safe and well tolerated: influenza-like symptoms were uncommon, laboratory toxicity was minimal, no adverse neurobehavioral side effects were evident, and no patient developed neutralizing antibodies against IFN, IFN-alpha n3 induced IFN-specific biologic responses and dose-related antiviral activity against HIV-1, Subjects showed stabilization of CD4 cells for >20 months, IFN-alpha n3 should be studied in combination with other antiretroviral agents and in persons with more advanced HIV-1 infection. C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC. NATL NAVAL MED CTR,DIV INFECT DIS,BETHESDA,MD 20892. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. INTERFERON SCI INC,NEW BRUNSWICK,NJ 08901. NR 47 TC 35 Z9 35 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1996 VL 173 IS 5 BP 1107 EP 1114 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UF867 UT WOS:A1996UF86700008 PM 8627061 ER PT J AU Bhattacharjee, AK Opal, SM Taylor, R Naso, R Semenuk, M Zollinger, WD Moran, EE Young, L Hammack, C Sadoff, JC Cross, AS AF Bhattacharjee, AK Opal, SM Taylor, R Naso, R Semenuk, M Zollinger, WD Moran, EE Young, L Hammack, C Sadoff, JC Cross, AS TI A noncovalent complex vaccine prepared with detoxified Escherichia coli J5 (Rc chemotype) lipopolysaccharide and Neisseria meningitidis group B outer membrane protein produces protective antibodies against gram-negative bacteremia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PSEUDOMONAS-AERUGINOSA; MONOCLONAL-ANTIBODY; BACTERICIDAL ACTIVITY; LETHAL INFECTION; POLYSACCHARIDE; IMMUNIZATION; IMMUNOGENICITY; CHALLENGE; ANTISERUM; MUTANT AB Earlier studies showed that purified IgG from sera of rabbits immunized with a boiled Escherichia coli J5 (Re chemotype) whole cell vaccine protected neutropenic rats against gram-negative bacterial sepsis, In the present study, de-O-acylated J5 lipopolysaccharide (J5 DLPS) as a noncovalent complex with Neisseria meningitidis group B outer membrane protein (GBOMP) elicited anti-J5 LPS antibodies in rabbits, IgG prepared from immune rabbit sera protected neutropenic rats against lethal challenge with Pseudomonas aeruginosa 12:4:4 (Fisher Devlin immunotype 6), Sixteen of 26 rats treated with the postimmune serum IgG were protected compared with none of 20 rats treated with the control rabbit serum IgG (P <.001), In vitro binding studies showed binding of anti-J5 IgG to several gram-negative bacteria, These results indicate that a subunit vaccine made of J5 DLPS as a noncovalent complex with GBOMP may protect against gram-negative bacteremia. C1 BROWN UNIV,SCH MED,PROVIDENCE,RI 02912. UNIVAX BIOL INC,ROCKVILLE,MD. RP Bhattacharjee, AK (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 35 TC 44 Z9 47 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1996 VL 173 IS 5 BP 1157 EP 1163 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UF867 UT WOS:A1996UF86700014 PM 8627067 ER PT J AU Farr, JV Sullivan, JF AF Farr, JV Sullivan, JF TI Rethinking training in the 1990S SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article AB Training has become a growth industry during the 1980s and 1990s. A 1995 survey of U.S. industries with 100 or more employees reported that approximately $52 billion was spent annually on training employees, while total costs for all companies are estimated at $90 to $100 billion. As technology evolves, some experts in the architectural, engineering, and construction (AEC) industries predict that training costs will grow five-fold from current levels. Who is receiving all of this training, and why? How is training being conducted; and are there better ways to do it? Are there cost-effective ways to conduct training? These issues are critical if the AEC industry is to remain responsive and competitive in rapidly changing national and global markets. This paper surveys recent training trends, and insights are offered about how and-why the AEC industry trains employees. Considering recent technological innovations, new ideas are presented for how training could he conducted to exploit technology and deliver more relevant and economical training than is available using traditional training approaches. RP Farr, JV (reprint author), US MIL ACAD,DEPT SYST ENGN,W POINT,NY 10996, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0742-597X J9 J MANAGE ENG JI J. Manage. Eng. PD MAY-JUN PY 1996 VL 12 IS 3 BP 29 EP 33 DI 10.1061/(ASCE)0742-597X(1996)12:3(29) PG 5 WC Engineering, Industrial; Engineering, Civil SC Engineering GA UG945 UT WOS:A1996UG94500021 ER PT J AU Mather, B AF Mather, B TI Experimental observation of microstructural behavior of concrete SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Editorial Material RP Mather, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD MAY PY 1996 VL 8 IS 2 BP 109 EP 109 DI 10.1061/(ASCE)0899-1561(1996)8:2(109) PG 1 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA UG897 UT WOS:A1996UG89700008 ER PT J AU Jaworski, DC Higgins, JA Radulovic, S Vaughan, JA Azad, AF AF Jaworski, DC Higgins, JA Radulovic, S Vaughan, JA Azad, AF TI Presence of calreticulin in vector fleas (Siphonaptera) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE calreticulin; Siphonaptera; flea; blood feeding; arthropod; antithrombosis ID VIRUS TRANSMISSION; CAT FLEA; CLONING; IDENTIFICATION; ANTIGENS; ISOFORMS; BINDING; PROTEIN AB Calreticulin has been defined in the cat flea, Ctenophalides felis (Bouche), and oriental rat flea, Xenopsylla cheopis (Rothschild). Calreticulin, a major endoplasmic reticulum protein, was previously identified as a component of ixodid tick saliva. Using a riboprobe generated from the tick calreticulin complementary DNA (cDNA), we distinguished 2 transcripts for calreticulin in cat fleas by Northern blot analysis. Increased expression of calreticulin was not evident in fed versus unfed adult fleas. We were able to amplify a calreticulin flea product from fed female messenger RNA (mRNA) using primers designed from the tick calreticulin gene. One of these products hybridized to the tick riboprobe, Localization of specific antibody to cat flea tissues showed calreticulin in the midgut with no detection in the salivary glands. We also observed specific labeling of calreticulin with antibody in the ovaries of fed females. Several cat flea polypeptides appear to crossreact with anticalreticulin antibody in Western blots. We did not detect a calreticulin using antibody to the tick-secreted protein in cat flea salivary glands. This antibody did recognize a protein in the rat flea salivary glands. Our results show that fleas have calreticulin and, possibly several isoforms. It appears that the salivary glands of the cat and oriental rat flea differ in detectable levels of calreticulin. The specific antibody labeling of the ovaries is interesting and remains to be understood. Calreticulin's appearance in the midgut suggests a possible source of calreticulin as a flea secretion. Further studies are in progress to complete the sequencing of the flea polymerase chain reaction (PCR) product to compare to tick-secreted calreticulin. Comparisons to other blood-feeding arthropods at the protein and ene level are also being done. We hope to define further the expression of calreticulin in as, and in general, blood-feeding arthropods, with respect to its role in feeding and pathogen transmission. C1 UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA. USA, MED RES INST INFECT DIS, DIV APPL RES, FT DETRICK, MD 21702 USA. FU NIAID NIH HHS [AI-17828] NR 19 TC 18 Z9 18 U1 1 U2 5 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1996 VL 33 IS 3 BP 482 EP 489 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA UH447 UT WOS:A1996UH44700028 PM 8667398 ER PT J AU Williams, SC May, CC AF Williams, SC May, CC TI Nuclear medicine review manual on the Internet: A hypertext educational resource SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 1996 VL 37 IS 5 SU S BP 1413 EP 1413 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA UL625 UT WOS:A1996UL62501232 ER PT J AU Cerny, JE Amundson, MJ Mueller, CW Waldron, JA AF Cerny, JE Amundson, MJ Mueller, CW Waldron, JA TI Inquiry based learning, nursing student attitudes and the HIV patient SO JOURNAL OF NURSING EDUCATION LA English DT Article C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV HAWAII,SCH NURSING,HONOLULU,HI 96822. UNIV HAWAII,SCH SOCIAL WORK,HONOLULU,HI 96822. UNIV HAWAII,SCH MED,HONOLULU,HI 96822. RI Mueller, Charles/F-8426-2013 NR 23 TC 0 Z9 0 U1 0 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0148-4834 J9 J NURS EDUC JI J. Nurs. Educ. PD MAY PY 1996 VL 35 IS 5 BP 219 EP 222 PG 4 WC Nursing SC Nursing GA WQ915 UT WOS:A1996WQ91500005 PM 8718776 ER PT J AU Bisch, FC Bowen, KJ Hanson, BS Kudryk, VL Billman, MA AF Bisch, FC Bowen, KJ Hanson, BS Kudryk, VL Billman, MA TI Dental considerations for a Glanzmann's thrombasthenia patient - Case report SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE thrombasthenia; blood platelets ID PLATELET; IDENTIFICATION; PREVENTION; DISEASE; GENE AB GLANZMANN'S THROMBASTHENIA IS A QUALITATIVE platelet disorder characterized by a deficiency in the platelet membrane glycoproteins (GP) IIb-IIIa. It belongs to a group of hereditary platelet disorders typified by normal platelet numbers and a prolonged bleeding time. The bleeding seen in Glanzmann's thrombasthenia usually includes bruising, epistaxis, gingival hemorrhage, and menorrhagia. Spontaneous, unprovoked bleeding is unusual. The severity of bleeding is unpredictable in thrombasthenia and does not correlate with the severity of the platelet GP IIb-IIIa abnormality. The present case report describes the dental treatment of a patient with Glanzmann's thrombasthenia. A 39-year-old female with a history of Glanzmann's thrombasthenia presented for periodontal therapy for spontaneous gingival hemorrhage. The patient had been sporadically seen in the past and had a record of only returning for appointments on an ''emergency'' basis, The periodontal findings revealed a diagnosis of moderate to advanced adult periodontitis in all quadrants. After all dental options had been discussed, the treatment of choice was determined to be extraction of the remaining dentition and fabrication of immediate dentures. The patient received a loading dose of 5 grams of aminocaproic acid (EACA) intravenously 3 hours prior to the surgery. At the beginning of the extractions 1 gram of EACA per hour continuous infusion and a 6 pack of platelets was administered, The patient tolerated the extractions well. All sites healed normally. The patient has had no difficulty in adjusting to the dentures, The case report discusses a possible treatment option in a noncompliant patient having Glanzmann's thrombasthenia and briefly discusses other hereditary bleeding disorders with similar presentations. C1 DWIGHT DAVID EISENHOWER MED CTR,HEMATOL ONCOL SERV,FT GORDON,GA. USA,DENT ACTIV,FT MYERS,VA. RP Bisch, FC (reprint author), USA,DENT ACTIV,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 22 TC 9 Z9 10 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD MAY PY 1996 VL 67 IS 5 BP 536 EP 540 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UM411 UT WOS:A1996UM41100012 PM 8724714 ER PT J AU Tolson, GE Czuszak, CA Billman, MA Lewis, DM AF Tolson, GE Czuszak, CA Billman, MA Lewis, DM TI Report of a lateral periodontal cyst and gingival cyst occurring in the same patient SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE periodontal cysts; odontogenic cysts ID ADULT AB THE LATERAL PERIODONTAL CYST and gingival cyst of the adult are both developmental odontogenic cysts located predominantly in the mandibular premolar-canine region. In this paper, a case report is described of a lateral periodontal cyst and gingival cyst occurring in the same patient along with a discussion of clinical, radiographic, and histological features of these lesions. C1 USA,DENTAC,DEPT PERIODONT,FT GORDON,GA 30905. EISENHOWER ARMY MED CTR,DEPT ORAL SURG,FT GORDON,GA. NR 10 TC 8 Z9 8 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD MAY PY 1996 VL 67 IS 5 BP 541 EP 544 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UM411 UT WOS:A1996UM41100013 PM 8724715 ER PT J AU Cameron, SM Craddock, MR AF Cameron, SM Craddock, MR TI The modification of implant tightening components for use with torque drivers SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 EISENHOWER ARMY MED CTR,PROSTHODONT RESIDENCY PROGRAM,FT GORDON,GA. USA,DENT ACTIV,FT GORDON,GA 30905. 561ST MED CO,GRAFENWOEHR,GERMANY. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1996 VL 75 IS 5 BP 576 EP 577 DI 10.1016/S0022-3913(96)90468-0 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UJ930 UT WOS:A1996UJ93000021 PM 8709029 ER PT J AU Vogelgesang, SA Heyes, MP West, SG Salazar, AM Sfikakis, PP Lipnick, RN Klipple, GL Tsokos, GC AF Vogelgesang, SA Heyes, MP West, SG Salazar, AM Sfikakis, PP Lipnick, RN Klipple, GL Tsokos, GC TI Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations SO JOURNAL OF RHEUMATOLOGY LA English DT Article DE systemic lupus erythematosus; quinolinic acid; neuropsychiatric manifestations ID CENTRAL-NERVOUS-SYSTEM; KYNURENINE PATHWAY METABOLISM; CEREBROSPINAL-FLUID; L-TRYPTOPHAN; HUNTINGTONS-DISEASE; RAT-BRAIN; CLASSIFICATION; INCREASES; MECHANISM; CRITERIA AB Objective. To evaluate the relationship between quinolinic acid, a neuroactive metabolite of L-tryptophan, and neuropsychiatric manifestations of systemic lupus erythematosus (SLE). Methods. Forty specimens of cerebrospinal fluid (CSF) were obtained from 39 patients with SLE who were evaluated for 40 episodes of neuropsychiatric dysfunction. The diagnosis of the neuropsychiatric dysfunction was determined clinically. CSF and serum specimens were analyzed for levels of quinolinic acid without knowledge of the clinical diagnosis. Results. Neuropsychiatric dysfunction attributed to SLE (NPSLE) was confirmed in 30 patient-episodes (Group 1), whereas in the other 10 (Group 2) other etiologies were felt to explain their CNS dysfunction. The median levels of CSF quinolinic acid for Group 1 (232.5 nmol/l) were significantly higher than those for Group 2 (median 38.2 nmol/l) (p < 0.014). CSF and serum quinolinic acid levels correlated significantly (p < 0.003) but there was no correlation between CSF quinolinic acid and CSF protein concentrations or white blood cell counts. Conclusion. We conclude that elevated quinolinic acid levels in the CSF and serum may be associated with NPSLE and could possibly play a role in its pathogenesis. C1 WALTER REED ARMY MED CTR,RHEUMATOL SERV,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,RHEUMATOL SERV,AURORA,CO 80045. NIMH,ANALYT BIOCHEM SECT,CLIN SCI LAB,BETHESDA,MD 20892. WRAMC,DEPT CLIN INVEST,BETHESDA,MD. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WRAMC,DEPT NEUROL,WASHINGTON,DC 20307. USUHS,DEPT NEUROL,WASHINGTON,DC. WRAMC,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 30 TC 21 Z9 21 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD MAY PY 1996 VL 23 IS 5 BP 850 EP 855 PG 6 WC Rheumatology SC Rheumatology GA UJ948 UT WOS:A1996UJ94800012 PM 8724297 ER PT J AU McClean, MD Clay, JL AF McClean, MD Clay, JL TI Simulation of lower-lip motor unit activity and movements in speech SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Letter ID RECRUITMENT; DIRECTION AB A computer model is described which is intended to aid in the interpretation of electromyographic-kinematic studies of lower-lip movements for speech. The model consists of three muscles having forcing functions which act to produce displacements of a common point. Each muscle is represented as a set of single motor units. The results of parametric analyses indicate (1) linear associations between parameters of motor unit discharge and movement, (2) a strong dependence of velocity-displacement ratios on spike-burst duration, and (3) variations in movement direction with changes in the relative timing of different muscles. RP McClean, MD (reprint author), WALTER REED ARMY MED CTR,AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. NR 19 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 1996 VL 99 IS 5 BP 3249 EP 3252 DI 10.1121/1.414871 PG 4 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA UK253 UT WOS:A1996UK25300066 ER PT J AU Ballato, A Ballato, J AF Ballato, A Ballato, J TI High-frequency piezoceramic equivalent circuit SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article AB Ferroelectric ceramics are strong candidates to provide thin-film resonant microstructures for future telecommunications applications, The frequency ranges of greatest commercial interest are the VHF and UHF bands. In these bands it is especially difficult to obtain adequate and reproducible characterizations of resonance behavior. We have developed a highly accurate equivalent network for these frequencies, Descriptions in circuit terms permit representation of the ceramic properties in a form directly accessible to the designer of the equipment in which the resonator will be embedded. In this communication we introduce the new network, and give typical parameters for a practical application. C1 RUTGERS STATE UNIV,DEPT CERAM SCI & ENGN,PISCATAWAY,NJ 08855. RP Ballato, A (reprint author), USA,RES LAB,AMSRL PS,FT MONMOUTH,NJ 07703, USA. NR 6 TC 3 Z9 4 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAY PY 1996 VL 79 IS 5 BP 1413 EP 1415 DI 10.1111/j.1151-2916.1996.tb08606.x PG 3 WC Materials Science, Ceramics SC Materials Science GA UM323 UT WOS:A1996UM32300042 ER PT J AU Denucci, DJ Dionne, RA Dubner, R AF Denucci, DJ Dionne, RA Dubner, R TI Identifying a neurobiologic basis for drug therapy in TMDs SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CHRONIC PAIN PATIENTS; DYSFUNCTION SYNDROME; DIABETIC NEUROPATHY; JOINT DYSFUNCTION; NONMALIGNANT PAIN; SPLINT THERAPY; OPIOID THERAPY; FACIAL-PAIN; AMITRIPTYLINE AB Emerging results from clinical and basic research indicate that persistent pain results in changes in the central nervous system. These changes may help explain chronic orofacial pain and lead to new therapies. The authors review data that support the use of tricyclic antidepressants for neurogenic or atypical pain, and benzodiazepines for musculoskeletal pain. Dentists must weigh the benefits of the chronic administration of a drug for the management of temporomandibular disorders against the equivocal scientific support for the use of many drug classes and the potential for serious toxicity with prolonged administration. C1 NIDR,NATL INST HLTH,NEUROBIOL & ANESTHESIOL BRANCH,BETHESDA,MD 20892. UNIV MARYLAND,BALTIMORE COLL DENT SURG,DEPT ORAL & CRANIOFACIAL BIOL SCI,SCH MED,BALTIMORE,MD 21201. RP Denucci, DJ (reprint author), USA,WALTER REED ARMY MED CTR,DENT CORPS,BETHESDA,MD, USA. NR 80 TC 33 Z9 34 U1 0 U2 0 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD MAY PY 1996 VL 127 IS 5 BP 581 EP 593 PG 13 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UK210 UT WOS:A1996UK21000014 PM 8642138 ER PT J AU Chu, D Gilman, S AF Chu, D Gilman, S TI Methanol electro-oxidation on unsupported Pt-Ru alloys at different temperatures SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID SOLID POLYMER ELECTROLYTE; FUEL-CELLS; AD-ATOMS; PLATINUM; ELECTROOXIDATION; ELECTROCATALYSIS; ENHANCEMENT; CATALYSTS; CARBON AB A wide compositional range of unsupported platinum-ruthenium alloy catalysts were prepared by thermal decomposition of the chlorides and chloroacids. The electrocatalysts were characterized by cyclic voltammetry, x-ray diffraction, and energy-dispersive x-ray spectroscopy. The BET surface area of the electrocatalysts increases with increasing Ru content up to similar to 70 atomic percent (a/o) and then reaches a plateau value. Electrodes fabricated from the electrocatalysts were also evaluated as anodes for methanol electro-oxidation in sulfuric acid over a range of temperatures. Unlike the situation for pure Pt, Ru is inactive for methanol electro-oxidation at 25 degrees C but becomes active at higher temperatures. The peak current observed during an anodic potential scan gradually shifts to more cathodic potentials with increasing temperature. When a comparison is made on the basis of electrode geometric surface area, a similar to 50 a/o ruthenium electrocatalyst provides the highest activity for methanol electro-oxidation at both 25 and 60 degrees C. The methanol electro-oxidation rate is 0.5 orders with respect to methanol concentration (between 0.1 and 2 M) for the Pt-Ru (similar to 50.50) electrode. RP Chu, D (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 41 TC 253 Z9 257 U1 3 U2 29 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAY PY 1996 VL 143 IS 5 BP 1685 EP 1690 DI 10.1149/1.1836700 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA UK930 UT WOS:A1996UK93000042 ER PT J AU Chu, CS Matylevich, NP McManus, AT Mason, AD Pruitt, BA AF Chu, CS Matylevich, NP McManus, AT Mason, AD Pruitt, BA TI Direct current reduces wound edema after full-thickness burn injury in rats SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article AB Objective: To observe the effect of 4 and 40 mu A direct current (DC) on edema formation after burn injury in rats. Design, Materials, and Methods: Silver-nylon wound dressings were used as either anodes (-) or cathodes (+) on 20% total body surface area full-thickness scalds in anesthetized male Sprague-Dawley rats. Untreated burned rats and rats treated with silver-nylon dressings without current were used as controls. Measurements and Main Results: Immediately applied, continuous DC reduced burn edema by 17 to 48% at different times up to 48 hours postburn (p < 0.001). Neither reversal of electrode polarity nor change in current density had any significant effect on the results of treatment. Starting treatment during the first 8 hours postburn produced the least edema accumulation, but the reduction was significant even when DC was applied 36 hours afterburn. If started immediately after injury, treatment had to be continued a minimum of 8 hours to be most effective. Conclusions: Direct electric current has a beneficial effect in reducing wound edema after burn injury. RP Chu, CS (reprint author), USA,INST SURG RES,LIB BRANCH,2322 HARNEY RD,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 12 Z9 14 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 1996 VL 40 IS 5 BP 738 EP 742 DI 10.1097/00005373-199605000-00009 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA UK405 UT WOS:A1996UK40500009 PM 8614072 ER PT J AU Cazier, PR Sponaugle, DW AF Cazier, PR Sponaugle, DW TI ''Starry sky'' liver with fasting: Variations in glycogen stores? SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. NR 6 TC 6 Z9 6 U1 0 U2 0 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD MAY PY 1996 VL 15 IS 5 BP 405 EP 407 PG 3 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA UG693 UT WOS:A1996UG69300010 PM 8731450 ER PT J AU Moul, JW Douglas, TH McCarthy, WF McLeod, DG AF Moul, JW Douglas, TH McCarthy, WF McLeod, DG TI Black race is an adverse prognostic factor for prostate cancer recurrence following radical prostatectomy in an equal access health care setting SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; prostatectomy; racial stocks; prognosis; blacks ID TESTOSTERONE LEVELS; WHITE; ADENOCARCINOMA; CARCINOMA; SURVIVAL; STAGE AB Purpose: We determined if black men with clinically localized adenocarcinoma of the prostate have the same recurrence-free outcome following radical prostatectomy, and whether they have similar preoperative, operative and pathological characteristics as white men in an equal access health care environment. Materials and Methods: We studied consecutive single hospital case series of 366 white and 107 black patients who underwent radical prostatectomy between 1975 and February 29, 1995. Evaluation included comprehensive retrospective chart review, prospective data collection and proactive followup. Univariate and multivariate statistical analyses were done of preoperative, operative, pathological and recurrence data by race. Results: Although the incidences of hypertension and diabetes, pretreatment prostate specific antigen (PSA) and serum creatinine measurements, elevated PSA as an indication for biopsy and clinical stage were greater in black men, the operative variables of blood loss, operative time and performance of a nerve sparing procedure were not different. The incidence of margin positivity was greater in black patients but pathological stage, Gleason score and seminal vesicle or nodal involvement were not different. Black race was an adverse prognostic factor for recurrence following radical prostatectomy after multivariate adjustment for pretreatment PSA and acid phosphatase, organ confinement status and tumor grade. Conclusions: The poorer recurrence-free outcome for black patients even after multivariate adjustment suggests a potentially more aggressive variant of prostate cancer in this population, the etiology of which is unknown. Race should be a stratification factor in clinical trials, especially those including radical prostatectomy and using recurrence-free outcome as an end point. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP Moul, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 36 TC 133 Z9 136 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1996 VL 155 IS 5 BP 1667 EP 1672 DI 10.1016/S0022-5347(01)66160-3 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA UF008 UT WOS:A1996UF00800038 PM 8627850 ER PT J AU Pearton, SJ Abernathy, CR Vartuli, CB Lee, JW MacKenzie, JD Wilson, RG Shul, RJ Ren, F Zavada, JM AF Pearton, SJ Abernathy, CR Vartuli, CB Lee, JW MacKenzie, JD Wilson, RG Shul, RJ Ren, F Zavada, JM TI Unintentional hydrogenation of GaN and related alloys during processing SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 42nd National Symposium of the American-Vacuum-Society CY OCT 16-20, 1995 CL MINNEAPOLIS, MN SP Amer Vacuum Soc ID VAPOR-PHASE EPITAXY; MOLECULAR-BEAM EPITAXY; III-V MATERIALS; COOLING AMBIENT; GAAS; CARBON; ZN; PASSIVATION; DEPOSITION; ACCEPTORS AB Atomic hydrogen plays an important role in GaN, passivating the electrical activity of Mg accepters during cooldown after metal organic chemical vapor deposition growth, and thereby preventing achievement of high p-type doping levels unless an annealing step is performed. We have found that hydrogen is easily incorporated into GaN and related materials during many different process steps, including boiling in water, wet chemical etching in KOH-based solutions, dielectric deposition using SiH4 or dry etching in Cl-2/CH4/H2Ar electron cyclotron resonance plasmas. In each of these cases we have employed deuterated chemicals and detected the incorporation of deuterium into GaN using high sensitivity secondary ion mass spectroscopy measurements. Hydrogen is found to have a diffusivity of >10(-11) cm(2)s(-1) at 170 degrees C, and to passivate the electrical activity of Mg and C accepters and also the native shallow donors in InGaN and InAlN. Annealing at 450-500 degrees C restores the electrical activity, but the hydrogen does not physically leave the films until much higher (similar to 800 degrees C)temperatures. The activation energies for dopant reactivation are of the order of 2.5 eV in bulk samples, where hydrogen retrapping is expected to be significant. (C) 1996 American Vacuum Society. C1 HUGHES RES LABS,MALIBU,CA 90265. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. AT&T BELL LABS,MURRAY HILL,NJ 07974. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Pearton, SJ (reprint author), UNIV FLORIDA,GAINESVILLE,FL 32611, USA. RI Schaff, William/B-5839-2009 NR 32 TC 27 Z9 27 U1 0 U2 9 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1996 VL 14 IS 3 BP 831 EP 835 DI 10.1116/1.580398 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA UR134 UT WOS:A1996UR13400031 ER PT J AU McLane, GF Monahan, T Eckart, DW Pearton, SJ Abernathy, CR AF McLane, GF Monahan, T Eckart, DW Pearton, SJ Abernathy, CR TI Magnetron reactive ion etching of group III-nitride ternary alloys SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 42nd National Symposium of the American-Vacuum-Society CY OCT 16-20, 1995 CL MINNEAPOLIS, MN SP Amer Vacuum Soc ID MOLECULAR-BEAM EPITAXY; PLASMAS; GROWTH AB Magnetron reactive ion etching of the group III-nitride ternary alloys InxGa1-xN and InxAl1-xN was investigated in BCl3 plasmas and also in SF6/BCl3, H-2/BCl3, and Ar/BCl3 gas mixtures. Etch rates were determined as a function of cathode power density, flow rate, pressure, and gas composition. Etch rates were achieved that were four to six times greater than previously reported for these materials, and at low cathode bias voltages (<100 V). The addition of H-2 and Ar to concentrations of 60% in BCl3 increased In0.25Ga0.75N etch rates by 35% and 90%, respectively. Auger electron spectroscopy measurements on In0.75Al0.25N showed a reduction in the surface In/Al ratio upon etching, but essentially no change in the surface composition of etched In0.25Ga0.75N. (C) 1996 American Vacuum Society. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. RP McLane, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 16 TC 10 Z9 10 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1996 VL 14 IS 3 BP 1046 EP 1049 DI 10.1116/1.580131 PN 1 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA UR134 UT WOS:A1996UR13400072 ER PT J AU Ren, F Lothian, JR Kuo, JM Hobson, WS Lopata, J Caballero, JA Pearton, SJ Cole, MW AF Ren, F Lothian, JR Kuo, JM Hobson, WS Lopata, J Caballero, JA Pearton, SJ Cole, MW TI BCl3/N-2 dry etching of InP, InAlP, and InGaP SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MICROWAVE AB Etch rates for InP, InAlP, and InGaP can be controlled between similar to 1500 Angstrom/min and >1 mu m/min by varying the microwave power, rf power, or N-2 composition in BCl3N2 discharges under electron cyclotron resonance conditions. The surface morphology of InGaP is poor at low microwave power (250 W), but becomes very smooth at high powers (1000 W). InP has exactly the opposite dependence on microwave power, while InAlP shows little change in morphology over a wide range of powers. The high ion current under electron cyclotron resonance conditions enables etching of In-based semiconductors without the need for high sample temperatures to enhance desorption of InClX species. (C) 1996 American Vacuum Society. C1 UNIV FLORIDA,GAINESVILLE,FL 32611. USA,RES LAB,FT MONMOUTH,NJ 07703. RP Ren, F (reprint author), AT&T BELL LABS,600 MT AVE,MURRAY HILL,NJ 07974, USA. NR 18 TC 17 Z9 17 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1996 VL 14 IS 3 BP 1758 EP 1763 DI 10.1116/1.588553 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA UU480 UT WOS:A1996UU48000031 ER PT J AU Myers, AF Camphausen, SM Cuomo, JJ Hren, JJ Liu, J Bruley, J AF Myers, AF Camphausen, SM Cuomo, JJ Hren, JJ Liu, J Bruley, J TI Characterization of amorphous carbon coated silicon field emitters SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 8th International Vacuum Microelectronics Conference (IVMC 95) CY JUL 31-AUG 03, 1995 CL PORTLAND, OR SP IEEE, ARPA, NRL, Japan Soc Promot Sci, AVS ID DIAMOND; GROWTH AB Amorphous carbon was deposited on needle-shaped Si field emitters by filtered cathodic are. Electron emission was obtained from these coated cathodes, but was reduced compared to emission from uncoated Si cathodes. Electron energy loss spectroscopy indicated that the coating was a high sp(2) content amorphous carbon. Au particles were found to have precipitated out of the Si emitters, which were grown by a vapor-liquid-solid technique utilizing the Au-Si eutectic during the oxidation and chemical etch sharpening of the emitters. High resolution transmission electron microscopy and selected area electron diffraction confirmed the amorphous nature of the coating and the presence of the Au particles at the Si surface. The field emission, electron energy loss spectroscopy, high resolution transmission electron microscopy, and selected area electron diffraction results are presented and discussed. (C) 1996 American Vacuum Society. C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. LEHIGH UNIV,DEPT MAT SCI & ENGN,BETHLEHEM,PA 18015. RP Myers, AF (reprint author), N CAROLINA STATE UNIV,DEPT MAT SCI & ENGN,BOX 7907,RALEIGH,NC 27695, USA. NR 27 TC 9 Z9 10 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1996 VL 14 IS 3 BP 2024 EP 2029 DI 10.1116/1.588978 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA UU480 UT WOS:A1996UU48000082 ER PT J AU Choi, WB Liu, J McClure, MT Myers, AF Zhirnov, VV Cuomo, JJ Hren, JJ AF Choi, WB Liu, J McClure, MT Myers, AF Zhirnov, VV Cuomo, JJ Hren, JJ TI Field emission from diamond coated molybdenum field emitters SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 8th International Vacuum Microelectronics Conference (IVMC 95) CY JUL 31-AUG 03, 1995 CL PORTLAND, OR SP IEEE, ARPA, NRL, Japan Soc Promot Sci, AVS ID ELECTRON-EMISSION; GRAPHITE AB Diamond deposition onto single Mo field emitters was accomplished by two methods: microwave plasma chemical vapor deposition and a dielectrophoresis of diamond powder. Observation by transmission electron microscopy and scanning electron microscopy revealed a significant amount of deposition at the tips. The field emission characteristics were measured before and after diamond deposition on the same emitters. Field emission from diamond coated emitters yielded significant increases in emission current and lower Fowler-Nordheim slopes. We discuss a possible mechanism to explain current enhancement that depends primarily upon the Mo-diamond interface. (C) 1996 American Vacuum Society. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RUSSIAN ACAD SCI,INST CRYSTALLOG,MOSCOW 117333,RUSSIA. RP Choi, WB (reprint author), N CAROLINA STATE UNIV,DEPT MAT SCI & ENGN,BOX 7907,RALEIGH,NC 27695, USA. OI choi, wonbong/0000-0002-7896-7655 NR 18 TC 37 Z9 37 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1996 VL 14 IS 3 BP 2050 EP 2055 DI 10.1116/1.588984 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA UU480 UT WOS:A1996UU48000088 ER PT J AU Dhar, NK Wood, CEC Gray, A Wei, HY SalamancaRiba, L Dinan, JH AF Dhar, NK Wood, CEC Gray, A Wei, HY SalamancaRiba, L Dinan, JH TI Heteroepitaxy of CdTe on {211}Si using crystallized amorphous ZnTe templates SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 15th North American Conference on Molecular Beam Epitaxy CY SEP 17-20, 1995 CL UNIV MARYLAND, COLLEGE PK, MD HO UNIV MARYLAND ID GROWTH; SI(100); SURFACE; HGCDTE AB CdTe films were grown by molecular-beam epitaxy on As-passivated nominal {211} Si substrates using thin interfacial ZnTe buffer layers. ZnTe layers were grown by the following two growth methods: (1) migration enhanced epitaxy (MEE) directly on Si and (2) MEE on 80 Angstrom templates of crystallized amorphous ZnTe buffers deposited directly on Si. CdTe films thicker than 8 mu m had threading dislocation densities in the range of 2.5 to 4 x 10(6) cm(-2) and 1 to 2 x 10(6) cm(-2) for methods (1) and (2), respectively. Double crystal x-ray rocking curve peak widths decreased from 550 to 120 arcsec as CdTe film thickness increased from 3 mu m to 9 mu m for samples grown by method (1), and for samples grown by method (2), peak widths decreased from 300 to 84 arcsec in the same thickness range. CdTe film grown on vicinal (211) Si substrates misoriented by 5 degrees toward [111] with ZnTe buffer layer prepared by method (2) had a dislocation density of 8 x 10(5) cm(-2) and an x-ray peak width of 72 arcsec. (C) 1996 American Vacuum Society. C1 UNIV MARYLAND,DEPT MAT & NUCL ENGN,COLLEGE PK,MD 20742. NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Dhar, NK (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. RI Salamanca-Riba, Lourdes/B-3785-2009 OI Salamanca-Riba, Lourdes/0000-0001-8155-6403 NR 12 TC 39 Z9 39 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1996 VL 14 IS 3 BP 2366 EP 2370 DI 10.1116/1.588862 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA UU480 UT WOS:A1996UU48000164 ER PT J AU Willey, RG Smith, DJ Duke, JH AF Willey, RG Smith, DJ Duke, JH TI Modeling water-resource systems for water-quality management SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article AB Water managers have been attempting to operate reservoirs in a ''best water management strategy'' to meet specific project objectives since the first man-made impoundment was constructed. When it was realized, several years ago, that the U.S. Army Corps of Engineers must have the capability to analyze the operation of large multiple reservoir systems for water quality, the Hydrologic Engineering Center (HEC) was funded to develop a computer program to meet this need. ''HEC-5Q, Simulation of Flood Control and Conservation Systems'' computer model has the unique capabilities to accept user-specified water quantity and quality needs systemwide, and to decide how to regulate a network of reservoirs. The decision criteria are programmed to consider flood control, hydropower, instream flow (municipal, industrial, irrigation, water supply, fish habitat), and water-quality requirements. A brief history and description of the HEC-5Q model is provided along with citations to related case studies and technical reports. C1 RESOURCE MANAGEMENT ASSOC,SUISUN CITY,CA 94585. RP Willey, RG (reprint author), USA,CORPS ENGINEERS,HYDRAUL ENGN CTR,609 2ND ST,DAVIS,CA 95616, USA. NR 41 TC 14 Z9 19 U1 1 U2 6 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAY-JUN PY 1996 VL 122 IS 3 BP 171 EP 179 DI 10.1061/(ASCE)0733-9496(1996)122:3(171) PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA UG712 UT WOS:A1996UG71200004 ER PT J AU Xu, BY Panchang, V Demirbilek, Z AF Xu, BY Panchang, V Demirbilek, Z TI Exterior reflections in elliptic harbor wave models SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID PARABOLIC EQUATION METHOD; BOUNDARY-CONDITIONS; WATER-WAVES; APPROXIMATIONS; DIFFRACTION; REFRACTION; RADIATION AB Traditional elliptic harbor wave models are based on the assumptions that the exterior sea region (i.e. the region outside the computational grid) is of constant depth and that the exterior coastlines are collinear and fully reflecting. This paper demonstrates that for most coastal regions, where these assumptions are generally not true, their effect on model results is substantial. This leads to unreliable simulations. Enlarging the model domain to overcome their effects is cumbersome and often prohibitive. To overcome these difficulties, the use of parabolic approximations of the mild-slope wave equation as open boundary conditions is explored. Suitable parabolic equations are derived and interfaced with an elliptic finite-element model. Since the parabolic approximation does not describe wave scattering as rigorously as the traditional method, the new model is tested against analytical and other solutions for cases where scattering is extensive. Errors resulting from the parabolic approximation are found to be extremely small. Further model rests show that for the generally realistic case where exterior reflection coefficients are less than unity, the new method requires considerably smaller domains than the traditional method, resulting in reduced modeling effort. The model is also applied to Toothacher Bay, Maine, and the use of the parabolic boundary conditions eliminates many spurious features in the simulation. C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. RP Xu, BY (reprint author), UNIV MAINE,DEPT CIVIL ENGN,ORONO,ME 04469, USA. NR 27 TC 23 Z9 28 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 1996 VL 122 IS 3 BP 118 EP 126 DI 10.1061/(ASCE)0733-950X(1996)122:3(118) PG 9 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA UG900 UT WOS:A1996UG90000003 ER PT J AU Scheffner, NW AF Scheffner, NW TI Systematic analysis of long-term fate of disposed dredged material SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB This paper describes a systematic methodology for predicting the fate and stability of dredged material disposal sites over long periods of time, ranging from months to years. The approach is based on the generation and use of databases of wave and current time series that describe environmental conditions specific to the site. These boundary conditions are used to drive a coupled hydrodynamic, sediment transport, and a bathymetry change model that provides a prediction of the long-term behavior of a disposal site of arbitrary dimensions. An example of an application of this approach is made for a moderately dispersive disposal mound located offshore of the entrance to Mobile Bay, Ala. RP Scheffner, NW (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39181, USA. NR 17 TC 5 Z9 5 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 1996 VL 122 IS 3 BP 127 EP 133 DI 10.1061/(ASCE)0733-950X(1996)122:3(127) PG 7 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA UG900 UT WOS:A1996UG90000004 ER PT J AU Houston, JR AF Houston, JR TI Simplified Dean's method for beach-fill design SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID PROFILE AB A simplified approach is presented to use Dean's method for determining dry-beach (subaerial) width after equilibrium for arbitrary sediment size. A simple equation is developed relating a key parameter in Dean's method to sediment diameter. Closure depth is shown to be simply related to nearshore mean annual significant wave height. Dean's equations for dry-beach width are dimensionalized and simplified. The key parameter, closure depth, and the equations for dry-beach width are all presented in simple forms that can be solved easily using a hand calculator. Examples are presented for all cases including fill sediment with a mean diameter the same size, larger, and smaller than the native sediment. When the fill sediment is finer than the native sediment a minimum quality of sediment has to be placed before there is any resulting dry beach, and an equation is provided to determine this minimum quantity. The simplified method presented allows an engineer to easily evaluate a large number of scenarios at the feasibility stage of a project. RP Houston, JR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 7 Z9 7 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 1996 VL 122 IS 3 BP 143 EP 146 DI 10.1061/(ASCE)0733-950X(1996)122:3(143) PG 4 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA UG900 UT WOS:A1996UG90000006 ER PT J AU Barth, J AF Barth, J TI Left-brain finance for right-brain people: A money guide for the creatively inclined - Monroe,PA SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 1996 VL 121 IS 8 BP 106 EP 106 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA UK201 UT WOS:A1996UK20100108 ER PT J AU Stretch, RH Wright, KM Bliese, PD Knudson, KH Marlowe, DH Hoover, CH AF Stretch, RH Wright, KM Bliese, PD Knudson, KH Marlowe, DH Hoover, CH TI Psychological health of Gulf War-era military personnel SO MILITARY MEDICINE LA English DT Article ID COMMON COLD; STRESS; SUSCEPTIBILITY AB This study assessed the effects of the Persian Gulf War on the psychological health and adjustment of military personnel in Hawaii and Pennsylvania who either deployed (N = 1,524) or did not deploy (N = 2,727) to the Persian Gulf during Operations Desert Shield/Desert Storm. Ah participants anonymously completed a questionnaire providing information on demographics, psychological and psychosocial health, deployment stressors, current life problems, current distress, and causal attributions of present problems. Results indicate that deployed veterans experienced significant levels of stress intheater and continue to report significant stress in their lives today. Although considerable stress is experienced, the majority of veterans are handling it unremarkably. Implications for future deployments and the need fdr military-normed assessment instruments are discussed. RP Stretch, RH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 10 TC 32 Z9 32 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1996 VL 161 IS 5 BP 257 EP 261 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA UK237 UT WOS:A1996UK23700007 PM 8855054 ER PT J AU Glass, KL Torrington, KG Dillard, TA Thompson, JC Phillips, YY AF Glass, KL Torrington, KG Dillard, TA Thompson, JC Phillips, YY TI Pulse oximetry correction for smoking exposure SO MILITARY MEDICINE LA English DT Article ID CARBON-MONOXIDE; CARBOXYHEMOGLOBIN LEVELS; POTENTIAL ERRORS; OXYGEN; SMOKERS AB Pulse oximetry oxygen saturation (SpO(2)) does not distinguish carboxyhemoglobin (COHb) from oxyhemoglobin (O(2)Hb), giving a false impression of the apparent degree of oxyhemoglobin saturation in smokers who have elevated levels of COHb, We questioned whether accounting for smoking exposure history could improve description of pulse oximetry by correcting for COHb levels, We evaluated smoking history and %SpO(2) as predictors of %O-2,Hb and %COHb by CO-oximetry of arterial blood in 18 actively smoking and 18 age-matched nonsmoking patients in a clinical pilot study. The difference between %SpO(2) and %O(2)Hb was significantly greater (p < 0.001) in the smokers (5.6 +/- 3.1) than the nonsmokers (2.1 +/- 2.1). This difference correlated with %COHb (r(p) = 0.789; p < 0.001) and the smoking exposure score (SES, r(p) = 0.621; p < 0.001), a six-point index we developed based on whether patients mere active smokers, refrained from smoking prior to testing, or were exposed to passive smoking in the home or workplace, The following formula summarizes the correction: %O(2)Hb = 0.882[%SpO(2)] - 0.968[SES] + 9.245 (r(p) = 0.841; SES = 2.478; p < 0.001). This pilot study suggests that smoking exposure history correlates with COHb levels and that correction for smoking exposure improves the accuracy of pulse oximetry. RP Glass, KL (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 21 TC 5 Z9 5 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1996 VL 161 IS 5 BP 273 EP 276 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UK237 UT WOS:A1996UK23700011 PM 8855058 ER PT J AU Fallo, GJ Czerw, RJ Wakefield, CW AF Fallo, GJ Czerw, RJ Wakefield, CW TI Effects of uncontrolled outdoor storage on the polymerization, manipulation, and appearance of visible light-cured composite resin and resin-modified glass ionomer materials SO MILITARY MEDICINE LA English DT Article ID SHELF-LIFE AB Four light-cured composite resins (Z100, Heliomolar RO, Herculite XRV, and Prisma APH) and two resin-modified glass ionomer restorative materials (Fuji II LC and VariGlas VLC) were placed in an uncooled, unheated outdoor storage shed for 12 months, Maximum and minimum ambient temperatures were recorded every 24 hours, Each month, samples were polymerized with a visible light source and alterations in polymerization were assessed using a scratch test. Problems with manipulation or changes in appearance were also monitored, Samples stored outdoors were compared to control samples maintained at room temperature [68-74 degrees F (20-23.3 degrees C)], Results showed that polymerization of all materials tested was apparently unaffected to any significant clinical degree by outdoor storage at temperatures ranging from 20 to 112 degrees F (-6.6-44.4 degrees C) over 12 months, Eight months into the study, the VariGlas VLC liquid had separated into a viscous gel and watery component, None of the other remaining materials demonstrated any changes in manipulation or appearance, All materials tested except VariGlas VLC appear suitable for use during military deployment or field training exercises under similar environmental conditions. RP Fallo, GJ (reprint author), USA,DENTAC,FT BENNING,GA 31905, USA. NR 8 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1996 VL 161 IS 5 BP 290 EP 293 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UK237 UT WOS:A1996UK23700015 PM 8855062 ER PT J AU Schomer, PD AF Schomer, PD TI 25 years of progress in noise standardization SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article; Proceedings Paper CT Conference on Noise Control - Where Do We Stand Today CY JUN 01, 1995 CL WASHINGTON, DC SP Acoust Soc Amer AB This paper documents the more than ten-fold growth in the number of standards and the program of work carried out by the Acoustical Society of America Standards directorate for the American National Standards Institute (ANSI) and for related international work with the International Organization for Standardization (ISO) and the International Electro-technical Commission (IEC), Not only has there been a huge increase in the work effort, but the emphasis has changed greatly, Now we work to ensure that ISO Standards are fair to all players and to ensure that ANSI Standards are compatible with ISO, While major U.S. industries are participating in this effort, more participation is needed by industry and government, Major industries with some significant involvement include automotive, construction and agricultural equipment, computer and business machines, hearing conservation equipment and audiological testing, and sirens and alarms, Many other industries such as aircraft, mining, rotating electrical machinery, and manufacturers of acoustical materials, attenuators, mufflers, and soundproof enclosures currently lack significant involvement in the ISO process, So greater involvement is required by significant sectors of U.S. industry. (C) 1996 Institute of Noise Control Engineering. RP Schomer, PD (reprint author), USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61820, USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU INST NOISE CONTROL ENG PI POUGHKEEPSIE PA PO BOX 3206 ARLINGTON BRANCH, POUGHKEEPSIE, NY 12603 SN 0736-2501 J9 NOISE CONTROL ENG JI Noise Control Eng. J. PD MAY-JUN PY 1996 VL 44 IS 3 BP 141 EP 148 DI 10.3397/1.2828396 PG 8 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA VA113 UT WOS:A1996VA11300006 ER PT J AU Pickler, RH Frankel, HB Walsh, KM Thompson, NM AF Pickler, RH Frankel, HB Walsh, KM Thompson, NM TI Effects of nonnutritive sucking on behavioral organization and feeding performance in preterm infants SO NURSING RESEARCH LA English DT Article AB The purpose of this study was to examine the effects of nonnutritive sucking (NNS) on behavioral organization and feeding performance in preterm infants. Thirteen preterm infants were observed at four bottle-feedings, two of which involved treatment with prefeeding NNS. NNS had a positive effect on oxygen saturation and behavior state, as well as on the initiation and duration of the first nutritive suck burst. C1 USA,NURSE CORPS,KIMBROUGH ARMY COMMUNITY HOSP,FT GEORGE G MEADE,MD. MED COLL VIRGINIA HOSP,RICHMOND,VA. RP Pickler, RH (reprint author), VIRGINIA COMMONWEALTH UNIV,RICHMOND,VA 23284, USA. RI Pickler, Rita/A-3239-2012; OI Pickler, Rita/0000-0001-9299-5583 NR 14 TC 40 Z9 43 U1 0 U2 0 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD MAY-JUN PY 1996 VL 45 IS 3 BP 132 EP 135 DI 10.1097/00006199-199605000-00002 PG 4 WC Nursing SC Nursing GA UP082 UT WOS:A1996UP08200003 PM 8637792 ER PT J AU Yancey, MK Hardin, EL Pacheco, C Kuslich, CD Donlon, TA AF Yancey, MK Hardin, EL Pacheco, C Kuslich, CD Donlon, TA TI Non-mosaic trisomy 16 in a third-trimester fetus SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID NEWBORN-INFANT; CHROMOSOME-16; PLACENTA AB Background: Trisomy 16 is the most common trisomy in first-trimester spontaneous abortions, suggesting a high rate of non-disjunction of this chromosome. Deoxyribonucleic acid studies in aborted conceptuses with trisomy 16 have demonstrated a maternal origin in all cases. There have been cases of confined placental mosaicism, fetal mosaicism, and partial trisomy involving chromosome 16 reported in term fetuses. However, to our knowledge, there have been no previous reports of a near-term fetus with full trisomy 16 since the advent of modern chromosomal banding techniques. Case: A 25-year-old Filipino woman underwent obstetric sonographic evaluation at 32 weeks' gestation; results were remarkable for oligohydramnios, severe growth restriction, and multiple dysmorphic features. Percutaneous umbilical blood sampling was performed for rapid karyotyping, viral serology, and blood profiles. The fetal karyotype was 47,XX,+16; the remainder of the laboratory analysis was unremarkable. The patient went into spontaneous labor at 35 weeks' gestation and delivered a stillborn female fetus (birth weight 783 g). Chromosomes from skin, brain, and chorionic villi were examined and all demonstrated trisomy 16 (47,XX,+16). Deoxyribonucleic acid primers for known polymorphic regions of chromosome 16 were used and determined the origin of the extra chromosome to be nondisjunction during paternal meiosis. Conclusion: Previously, full trisomy 16 has been thought to be incompatible with fetal survival past the early second trimester. This case also contrasts with previously reported experience with trisomy 16 in that parental origin studies determined that the extra chromosome 16 originated from the father, suggesting that paternal derivation of the additional chromosome may play a role in the ultimate phenotypic expression. C1 KAPIOLANI MED CTR,MOLEC & CLIN CYTOGENET LAB,HONOLULU,HI 96828. TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. NR 23 TC 17 Z9 17 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 1996 VL 87 IS 5 BP 856 EP 860 PN 2 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA UG785 UT WOS:A1996UG78500023 PM 8677115 ER PT J AU Rivard, B AF Rivard, B TI Optometric record keeping in a comprehensive health care environment SO OPTOMETRY AND VISION SCIENCE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Optometry CY DEC 11, 1994 CL SAN DIEGO, CA SP Amer Acad Optometry DE functional interfaces; interprofessional synergy; outcomes; profiling; paperless office; administrative vs clinical notes AB Optometric records which have evolved in private practice must be reconsidered when included in a comprehensive care environment. These hospital, health maintenance organization (HMO), preferred provider organization, and similarly linked systems require a higher degree of communication among specialties than do self-standing practices. Furthermore, the administrative requirements of such a system require more standardization, cost sensitivity, medicolegal compliance, and other elements peculiar to a comprehensive facility. The expanded scope of care provided by optometrists within a hospital requires familiarity with a new range of procedures, languages, and reports. Information from laboratories, radiology, and other areas must be incorporated into the optometric record. Continuity of care is more complex. Opportunities for strong interprofessional synergies within the organization arise directly from preactivity in optometric record keeping. New legal hot spots arise from questions of records ownership, access, and privacy. Billing procedures are becoming extremely important, with significant effects on quality assurance audits, coding, doctor ''profiling'' against fraud, and abuse; these priorities can interfere with clinical priorities. Driven primarily by the concerns and resources of large third-party payers, technology is making rapid changes in the form of optometric record keeping in comprehensive systems. Electronic data management will change the face of medical records, although administrative data will be digitized much more quickly than clinical notes. Comprehensive care environments will be the ''test beds'' for these technologies. Optometry is in a flood position to show its contribution to the health care team through leadership in the implementation of new record keeping models. RP Rivard, B (reprint author), USA,DEPT MED,507 WOOD RD,INDIANAPOLIS,IN 46216, USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD MAY PY 1996 VL 73 IS 5 BP 301 EP 306 DI 10.1097/00006324-199605000-00002 PG 6 WC Ophthalmology SC Ophthalmology GA UP279 UT WOS:A1996UP27900002 PM 8771579 ER PT J AU McVeigh, F Bifareti, L AF McVeigh, F Bifareti, L TI Criteria and issues of space and equipment allocation and utilization in a Comprehensive health care environment SO OPTOMETRY AND VISION SCIENCE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Optometry CY DEC 11, 1994 CL SAN DIEGO, CA SP Amer Acad Optometry RP McVeigh, F (reprint author), USA,HLTH CLIN,EYE CLIN,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD MAY PY 1996 VL 73 IS 5 BP 344 EP 349 DI 10.1097/00006324-199605000-00015 PG 6 WC Ophthalmology SC Ophthalmology GA UP279 UT WOS:A1996UP27900015 PM 8771592 ER PT J AU Engel, CC VonKorff, M Katon, WJ AF Engel, CC VonKorff, M Katon, WJ TI Back pain in primary care: Predictors of high health-care costs SO PAIN LA English DT Article DE health care; back pain; primary care ID MEDICAL-CARE AB The objective of this study was to describe the health care utilization and prospective predictors of high-cost primary-care back pain patients. In the primary-care clinics of a large, staff model health maintenance organization in western Washington State, 1059 subjects were selected from consecutive patients presenting for back pain. The design was a 1-year prospective cohort study. Patients' were interviewed 1 month after an index primary-care back pain visit. Costs (back pain and total) and utilization (back pain primary-care follow-up visits, back pain specialty visits, back pain hospitalizations, back pain radiologic procedures, and pain medicine fills) were tracked over the next 11 months. Predictors assessed at 1 month were back pain diagnosis (disc disorder/sciatica, arthritis, vs. other), chronic pain grade (measure of pain intensity and related dysfunction), pain persistence (days with pain in prior 6 months), depressive symptomatology, and back pain-related disability compensation (ever/never). For the sample, 21% of patients with back pain costs greater than or equal to $600 (high back pain costs) accounted for 66% of back pain costs, 42% of total costs, 55% of primary-care follow-up visits for back pain, 91% of back pain specialty visits, 100% of back pain hospitalizations, 51% of back pain radiologic procedures, and 52% of pain medicine fills. The 21% with total costs greater than or equal to $2700 (high total costs) accounted for 67.7% of total costs, 52% of back pain costs, 29% of primary-care follow-up visits for back pain, 66% of back pain specialty visits, 100% of back pain hospitalizations, 39% of back pain radiologic procedures, and 42% of pain medicine fills. Multivariable logistic regression analyses indicated that increasing chronic pain grade, more persistent pain, and disc disorder/sciatica were strong independent predictors of high total and high back pain costs. Increasing. depressive symptoms significantly predicted high total but not high back pain costs. Back pain disability compensation predicted high back pain but not high total costs. A minority of primary-care back pain patients accounted for a majority of health-care costs. Patients with high back pain costs accounted for more back pain-related health-care utilization than did patients with high total costs. Factors predicting subsequent high costs suggest behavioral interventions targeting dysfunction, pain persistence, and depression may reduce health-care utilization and prevent accumulation of high health-care costs among primary-care back pain patients. C1 GRP HLTH COOPERAT PUGET SOUND,CTR HLTH STUDIES,SEATTLE,WA 98101. UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT & BEHAV SCI RP10,DIV CONSULTAT LIAISON,SEATTLE,WA 98195. RP Engel, CC (reprint author), TRIPLER ARMY MED CTR,DEPT PSYCHIAT,HONOLULU,HI 96859, USA. NR 22 TC 112 Z9 115 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD MAY-JUN PY 1996 VL 65 IS 2-3 BP 197 EP 204 DI 10.1016/0304-3959(95)00164-6 PG 8 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA UV462 UT WOS:A1996UV46200006 PM 8826507 ER PT J AU Wang, NJ Rabitz, H Manka, AS Bowden, CM AF Wang, NJ Rabitz, H Manka, AS Bowden, CM TI Optimal control of piezophotonic and magnetophotonic switching in a dense medium of three-level atoms SO PHYSICAL REVIEW A LA English DT Article ID LOCAL-FIELD; COHERENCE; INVERSION; AMPLIFICATION; PULSES; INDEX AB We apply optimal control techniques to maximize the absorptionless index of refraction, the density-dependent piezophotonic switching between absorption and amplification, and the ground-state energy-level-spacing-dependent magnetophotonic switching of susceptibility in a dense medium of coherently prepared three-level systems. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898. RP Wang, NJ (reprint author), PRINCETON UNIV,DEPT CHEM,PRINCETON,NJ 08544, USA. NR 20 TC 2 Z9 2 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY PY 1996 VL 53 IS 5 BP R2940 EP R2943 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA UK940 UT WOS:A1996UK94000009 ER PT J AU Mulligan, ME Shanley, DJ AF Mulligan, ME Shanley, DJ TI Supramalleolar fatigue fractures of the tibia SO SKELETAL RADIOLOGY LA English DT Article DE stress fractures; fatigue fractures ID STRESS-FRACTURES; INSUFFICIENCY FRACTURES AB Objective. The objective of this paper is to describe fatigue fractures in the supramalleolar area of the tibia. The spectrum of imaging findings in 14 cases is presented, with emphasis on plain film radiographic findings. Design and patients. Fourteen patients with fatigue fractures in the supramalleolar area of the distal tibia were seen in a 6-year period. The 13 men and 1 woman had an age range from 14 to 64 years (mean 30 years). These patients had no underlying conditions that would predispose them to fractures. Sequential plain film radiographs and other special imaging studies (technetium-99m scans and computed tomography) were retrospectively reviewed. Results and conclusions. Initial plain film radiographs showed a horizontal linear band of increased density in only 2 cases, a subtle cortical bulge in 5 cases, a focal ''graying'' of the cortex in 2 cases, a single layer peri osteal reaction in 1 case, and no abnormality in the final 4 cases. Technetium-99m scans were done in 11 cases and showed focal areas of increased uptake in all 11. These areas of increased uptake were vertically orientated in 10. One patient had computed tomography showing cortical thickening around a linear lucency. The spectrum of imaging findings is similar to that seen in fatigue fractures in more common locations. Supramalleolar fatigue fractures should be suspected in patients who have pain in the distal tibia even when initial plain film radiographs are normal. When initial radiographs are normal, technetium-99m scans can confirm the diagnosis. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP Mulligan, ME (reprint author), UNIV MARYLAND,MED CTR,DEPT DIAGNOST RADIOL,22 S GREENE ST,BALTIMORE,MD 21201, USA. NR 20 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD MAY PY 1996 VL 25 IS 4 BP 325 EP 328 PG 4 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA UK425 UT WOS:A1996UK42500004 PM 8737995 ER PT J AU Muradov, NZ TRaissi, A Muzzey, D Painter, CR Kemme, MR AF Muradov, NZ TRaissi, A Muzzey, D Painter, CR Kemme, MR TI Selective photocatalytic destruction of airborne VOCs SO SOLAR ENERGY LA English DT Article ID OXIDATION AB This article describes a photocatalytic method for selective oxidation of the airborne nitroglycerine (NG), in the presence of ethanol and acetone vapors at high concentrations (exceeding 1% by volume). Process selectivities toward NG photooxidation were examined for various photoreactor configurations and UV lamps and techniques used for the photocatalyst preparation. In addition, we have studied the effect of temperature, residence time, various additives (e.g. ozone, water vapor, nitrogen), and initial concentration of the solvents in air. Our data indicate that modifying TiO2 with silico-tungstic acid (STA) catalyst results in selective NG oxidation without affecting ethanol and acetone significantly. Platinization of TiO2 showed an adverse effect on NG destruction selectivity. In general, low residence times and initial concentration of oxidants and high temperatures and initial concentration of solvents favor selectivity toward NG destruction. In the case of temperature, our observation can be explained by the temperature dependent gas diffusion and surface processes. In most cases, the yield of ethanol oxidation was generally higher than that of acetone. Results from the bench-scale experiments using artificial UV light sources were used to build and test a solar photocatalytic oxidation reactor for selective NG treatment in the presence of ethanol and acetone. Copyright (C) 1996 Elsevier Science Ltd. C1 UNIV CENT FLORIDA,FLORIDA SOLAR ENERGY CTR,COCOA,FL 32922. USN,CTR SURFACE WARFARE,INDIAN HEAD,MD 20640. USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. NR 16 TC 15 Z9 15 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-092X J9 SOL ENERGY JI Sol. Energy PD MAY PY 1996 VL 56 IS 5 BP 445 EP 453 DI 10.1016/0038-092X(96)00031-X PG 9 WC Energy & Fuels SC Energy & Fuels GA VB381 UT WOS:A1996VB38100009 ER PT J AU Cotell, CM Hirvonen, JK AF Cotell, CM Hirvonen, JK TI Effect of ion energy on the mechanical properties of ion beam assisted deposition (IBAD) wear resistant coatings SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 1st Australia/US Workshop on Critical Issues in High Performance Wear Resistant Films CY FEB 01-03, 1995 CL WOLLONGONG, AUSTRALIA SP CSIRO, Div Appl Phys, Lindfield NSW, Sutton Tools, Thomastown Vic, Sola Int Holdings, Adelaide SA, Broken Hill Pty, Port Kembla NSW DE ion beam assisted deposition; wear resistant coatings; ion energy; compressive stress; void densification; adhesion ID THIN-FILM ORIENTATION; DIAMOND-LIKE CARBON; MOLECULAR-DYNAMICS; INTERNAL-STRESSES; TIN FILMS; COMPRESSIVE STRESS; VAPOR-PHASE; METAL-FILMS; AG-ATOMS; GROWTH AB Ion beam assisted physical vapor deposition offers a number of advantages over other surface modification methods with respect to the properties of wear resistant coatings. These properties include density, adhesion to the substrate, crystallographic orientation, durability and resistance to degradation by moisture. These improved film properties derive from the physical and chemical processes associated with the impingement of energetic ions onto the surface of a growing film. Such processes include sputtering and desorption of atoms from the substrate, implantation of atoms into the substrate, chemical reactions at the surface, cluster nucleation and dissociation, enhancement of surface diffusion, atomic displacements in the bulk, as well as energy and momentum transfer to the atoms in the growing film. A review of models for the influence of ion energy and momentum transfer to a growing film suggests that the effects of ion bombardment may be categorized according to the ion energy. C1 USA,RES LAB,MAT DIRECTORATE,CC,AMSRL,ABERDEEN PROVING GROUND,MD 21005. RP Cotell, CM (reprint author), USN,RES LAB,SURFACE MODIFICAT BRANCH,CODE 6670,WASHINGTON,DC 20375, USA. NR 70 TC 16 Z9 18 U1 0 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD MAY PY 1996 VL 81 IS 1 BP 118 EP 125 DI 10.1016/0257-8972(95)02650-9 PG 8 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA UQ992 UT WOS:A1996UQ99200016 ER PT J AU Kotak, BG Semalulu, S Fritz, DL Prepas, EE Hrudey, SE Coppock, RW AF Kotak, BG Semalulu, S Fritz, DL Prepas, EE Hrudey, SE Coppock, RW TI Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss) SO TOXICON LA English DT Article ID ISOLATED RAT HEPATOCYTES; NETPEN LIVER-DISEASE; CYANOBACTERIAL TOXINS; PEPTIDE HEPATOTOXIN; AERUGINOSA; TOXICITY; WATER AB B. G. Kotak, S. Semalulu, D. L. Fritz, E. E. Prepas, S. E. Hrudey and R. W. Coppock. Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss). Toxicon 34, 517-525, 1996.-In 26 hr laboratory trials a dose of 1000 mu g/kg microcystin-LR (MC-LR) caused 100% mortality in rainbow trout, while no mortality was observed at doses of 400 mu g/kg or less. The liver to body mass ratio increased in fish exposed to the toxin which was likely due to water retention in the liver. In contrast to mammalian studies, hemorrhage of the liver was rare in fish. Exposure to MC-LR caused widespread hepatocellular swelling and lysis of hepatocyte plasma membranes, resulting in liquifactive necrosis (organelles floating in a milieux of cellular debris). Kidney lesions in the fish consisted of coagulative tubular necrosis with a dilation of Bowman's space. Lesions observed in the liver and kidney of fish exposed to MC-LR were considerably different than those previously reported for mammals. Copyright (C) 1996 Elsevier Science Ltd. C1 ALBERTA ENVIRONM CTR,ENVIRONM TOXICOL PROGRAM,VEGREVILLE,AB T0B 4L0,CANADA. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. UNIV ALBERTA,FAC MED,ENVIRONM HLTH PROGRAM,EDMONTON,AB T6G 2G3,CANADA. RP Kotak, BG (reprint author), UNIV ALBERTA,DEPT BIOL SCI,EDMONTON,AB T6G 2E9,CANADA. NR 28 TC 112 Z9 119 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 1996 VL 34 IS 5 BP 517 EP 525 DI 10.1016/0041-0101(96)00009-8 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA UN926 UT WOS:A1996UN92600003 PM 8783446 ER PT J AU Pau, CP Hu, DJ Spruill, C Schable, C Lackritz, E Kai, M George, JR Rayfield, MA Dondero, TJ Williams, AE Busch, MP Brown, AE McCutchan, FE Schochetman, G AF Pau, CP Hu, DJ Spruill, C Schable, C Lackritz, E Kai, M George, JR Rayfield, MA Dondero, TJ Williams, AE Busch, MP Brown, AE McCutchan, FE Schochetman, G TI Surveillance for human immunodeficiency virus type 1 group O infections in the United States SO TRANSFUSION LA English DT Article AB Background: Reports that the human immunodeficiency virus type 1 (HIV-1) group O variants are not reliably detected by some commercial diagnostic tests have raised concerns about the sensitivity of existing screening tests, especially with regard to blood safety. Although it is unlikely that these divergent strains are prevalent in North America, systematic, continuous surveillance is needed to monitor the potential spread of HIV variants into that region, Study Design and Methods: Stored serum samples (n = 1072) from both high- and low-risk population groups al several sites in the United Stales and Puerto Rico were tested by peptide enzyme immunoassays specific for the prototypic HIV-1 group O strains, MVP5180 and ANT70. Results: None of the 1072 samples examined had peptide reactivity that was consistent with HIV-1 group O infection. Conclusion: While no evidence of specific HIV-I group O (MVP5180 or ANT70) infection was found in this study, the sensitivity of current tests has not been fully evaluated against the wide range of genetic variation of HIV. Therefore, it is important to continue active surveillance far HIV-1 and HIV type 2 strains, to characterize any divergent strains, and to judiciously modify tests to correct for any deficiencies in sensitivity. C1 AMER RED CROSS,JEROME H HOLLAND LAB,ROCKVILLE,MD. IRWIN MEM BLOOD CTR,SAN FRANCISCO,CA. HENRY M JACKSON FDN RES LAB,ROCKVILLE,MD. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. RP Pau, CP (reprint author), CTR DIS CONTROL,NATL CTR INFECT DIS,DIV HIV AIDS,M-S D12,1600 CLIFTON RD,ATLANTA,GA 30333, USA. NR 10 TC 24 Z9 24 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAY PY 1996 VL 36 IS 5 BP 398 EP 400 DI 10.1046/j.1537-2995.1996.36596282582.x PG 3 WC Hematology SC Hematology GA UT758 UT WOS:A1996UT75800004 PM 8693502 ER PT J AU Wilhelmsen, CL Pitt, MLM AF Wilhelmsen, CL Pitt, MLM TI Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys SO VETERINARY PATHOLOGY LA English DT Article DE biotoxin; lectin; nonhuman primate ID PULMONARY-EDEMA; IMMUNOTOXINS; HUMANS; ABRIN; MICE AB Five unimmunized adult rhesus monkeys weighing 5.9-6.3 kg were challenged with a precalculated, inhaled dose of 20.95-41.8 mu g/kg of aerosolized ricin. Two males and three females either died or were killed at the onset of respiratory distress between 36 and 48 hours post-ricin inhalation and were necropsied. Consistent gross and microscopic lesions were confined to the thoracic cavity. All monkeys had multifocal to coalescing fibrinopurulent pneumonia, diffuse necrosis, and acute inflammation of airways, and nearly diffuse alveolar flooding, with peribronchovascular edema. All monkeys also had purulent tracheitis, fibrinopurulent pleuritis, and purulent mediastinal lymphadenitis. One male monkey and one female monkey had bilateral adrenocortical necrosis. We attributed the cause of death to asphyxiation following massive pulmonary alveolar flooding. The lesions of acute inhaled ricin intoxication in rhesus monkeys closely resembled those lesions reported in rats with acute inhaled ricin intoxication. C1 USA,DIV PATHOL,MED RES INST INFECT DIS,FT DETRICK,MD 21702. RP Wilhelmsen, CL (reprint author), USA,TOXINOL DIV,MED RES INST INFECT DIS,FT DETRICK,MD 21702, USA. NR 26 TC 58 Z9 63 U1 0 U2 1 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD MAY PY 1996 VL 33 IS 3 BP 296 EP 302 PG 7 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA UJ530 UT WOS:A1996UJ53000006 PM 8740703 ER PT J AU Oberste, MS Parker, MD Smith, JF AF Oberste, MS Parker, MD Smith, JF TI Complete sequence of venezuelan equine encephalitis virus subtype IE reveals conserved and hypervariable domains within the C terminus of nsP3 SO VIROLOGY LA English DT Article ID CULEX MELANOCONION TAENIOPUS; ENCEPHALOMYELITIS VIRUS; VECTOR COMPETENCE; E2 GLYCOPROTEIN; CDNA CLONE; E2-GLYCOPROTEIN; IDENTIFICATION; ALPHAVIRUSES; NUCLEOTIDE; EPITOPES AB The complete nucleotide and predicted amino acid sequences of Venezuelan equine encephalitis (VEE) virus subtype IE (isolate 68U201) were determined and compared to those of other antigenic variants within the VEE complex, strains IAB-TrD, IC-P676, lD-3880, IE-Menall, and II-Fe3-7c. The 68U201 structural proteins were most closely related to their Menall counterparts (97-100% identity) and more distantly related to VEE strains of other antigenic varieties (83-93% identity). With the exception of nsP3, the 68U201 nonstructural proteins were 94-95% identical to those of TrD, P676, and 3880 (nonstructural gene sequences are not available for Menall and Fe3-7c). The amino-terminal region of nsP3 (aa 1-329), which is highly conserved among all alphaviruses, was 93-94% identical for all VEE strains. The nsP3 carboxyl region is highly divergent among alphaviruses in general, but well conserved among previously sequenced VEE strains (>90% identity). Surprisingly, the carboxyl region of 68U201 nsP3 (aa 330-563) was only 59-61% identical to that of subtype IAB, IC, and ID viruses, with large insertions and deletions in addition to numerous substitutions. The differences between the 68U201 and other VEE nsP3 carboxyl regions were not randomly distributed, as there were four domains of high similarity within the nonconserved region. To examine this divergence more closely, we sequenced a portion of the Menall ns3 gene. The 68U201 and Menall nsP3 nonconserved regions were 85.3% identical and had the same basic domain structure, which was distinct from the IAB, IC, and ID nsP3 proteins, suggesting that the domain structure of nsP3 may be subtype/variety-specific. VEE nsP3 sequence diversity may reflect ecological differences such as adaptation to different mosquito vectors or vertebrate hosts. (C) 1996 Academic Press, Inc. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. NR 36 TC 29 Z9 29 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD MAY 1 PY 1996 VL 219 IS 1 BP 314 EP 320 DI 10.1006/viro.1996.0254 PG 7 WC Virology SC Virology GA UJ532 UT WOS:A1996UJ53200039 PM 8623548 ER PT J AU Schwenk, B GubreXabier, M White, K Krzych, U AF Schwenk, B GubreXabier, M White, K Krzych, U TI Role of the MHC class I molecules and liver-resident T cells in protective immunity induced with attenuated Plasmodium berghei sporozoites. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 109 EP 109 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86100339 ER PT J AU Gagnon, SJ Green, S Vaughn, DV Kalayanarooj, S Suntayakorn, S Nisalak, A Nimmanitya, S Innis, BL Kurane, I Rothman, AL Ennis, FA AF Gagnon, SJ Green, S Vaughn, DV Kalayanarooj, S Suntayakorn, S Nisalak, A Nimmanitya, S Innis, BL Kurane, I Rothman, AL Ennis, FA TI Increased cytokine protein and mRNA levels in patients with dengue hemorrhagic fever. SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,WORCESTER,MA 01605. BANGKOK CHILDRENS HOSP,BANGKOK,THAILAND. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 301 EP 301 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86100532 ER PT J AU Lyon, J Seguin, M Ockenhouse, C Ballou, R Emler, C JennensClough, M Fuller, D Haynes, J Sheehy, M AF Lyon, J Seguin, M Ockenhouse, C Ballou, R Emler, C JennensClough, M Fuller, D Haynes, J Sheehy, M TI Serological responses elicited by a P-falciparum trap nucleic acid vaccine. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. AGRACETUS INC,MIDDLETON,WI 53562. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 468 EP 468 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86100698 ER PT J AU Leitner, W Seguin, M Ballou, R Lyon, J Schultz, A Sheehy, M AF Leitner, W Seguin, M Ballou, R Lyon, J Schultz, A Sheehy, M TI Epidermal and intramuscular immunization with nucleic acid vaccines against P-berghei malaria SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. AGRACETUS INC,MIDDLETON,WI 53562. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 471 EP 471 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86100702 ER PT J AU Pratt, WD Ludwig, GY AF Pratt, WD Ludwig, GY TI Protection of mice against aerosol challenge with Venezuelan equine encephalitis virus by alphavirus specific monoclonal antibodies SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 481 EP 481 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86100713 ER PT J AU Wang, Y Zhang, X Weitz, J Jett, M AF Wang, Y Zhang, X Weitz, J Jett, M TI Heteropolyanions do not induce P-glycoprotein associated with multidrug resistance in human breast cancer cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 842 EP 842 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101074 ER PT J AU Matyas, GR Alving, CR AF Matyas, GR Alving, CR TI Protection against ricin by intranasal immunization with liposomes. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1099 EP 1099 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101328 ER PT J AU Bavari, S Pless, D Callahan, K Ulrich, RG AF Bavari, S Pless, D Callahan, K Ulrich, RG TI Processing and presentation of bacterial superantigens. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1220 EP 1220 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101448 ER PT J AU Saikh, KU Conlon, K Ulrich, RG AF Saikh, KU Conlon, K Ulrich, RG TI Functional maturation of human dendritic cells proceeds through a MHC class II negative precursor. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. US FDA,OTRR,CTR BIOL EVAL RES,ROCKVILLE,MD 20853. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1238 EP 1238 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101465 ER PT J AU Komisar, J Essiet, I Tseng, J AF Komisar, J Essiet, I Tseng, J TI Protection of mice against lethal enterotoxic shock with anti-interferon gamma. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1288 EP 1288 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101519 ER PT J AU Gordon, RK AF Gordon, RK TI Molecular modeling of a series of 3-deaza-adenosine (DZA) analogs: Correlation with anti-HIV activity. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1332 EP 1332 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101563 ER PT J AU Leader, H Gordon, RK Lenavitt, JA Chiang, PK AF Leader, H Gordon, RK Lenavitt, JA Chiang, PK TI Antimuscarinic potencies of carbamyl-aprophen compounds. SO FASEB JOURNAL LA English DT Meeting Abstract C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1342 EP 1342 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101571 ER PT J AU Ray, P Flink, M Middleton, W AF Ray, P Flink, M Middleton, W TI Mechanism of mastoparan action in the stimulation of acetylcholine release and its inhibition by botulinum toxin A in PC12 cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1648 EP 1648 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101878 ER PT J AU Keller, SA Benton, BJ Spriggs, D Capacio, BR Chang, FCT AF Keller, SA Benton, BJ Spriggs, D Capacio, BR Chang, FCT TI The therapeutic window of 4-aminopyridine, a compound effective against the lethal effects of saxitoxin. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1650 EP 1650 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101879 ER PT J AU Ray, R Benton, BJ Anderson, DR Byers, SL Petrali, JP AF Ray, R Benton, BJ Anderson, DR Byers, SL Petrali, JP TI Protection against sulfur mustard by chelation of intracellular free calcium. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1655 EP 1655 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101882 ER PT J AU Bhat, KR Benton, BJ Ray, R AF Bhat, KR Benton, BJ Ray, R TI Incision-excision DNA repair mechanism with concurrent activation of poly(ADP-ribose) polymerase and DNA ligase. SO FASEB JOURNAL LA English DT Meeting Abstract C1 LINCOLN UNIV,DEPT CHEM,LINCOLN,PA 19352. USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 1657 EP 1657 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86101886 ER PT J AU Kovacs, B Vassilopoulos, D Vogelgesang, SA Tsokos, GC AF Kovacs, B Vassilopoulos, D Vogelgesang, SA Tsokos, GC TI Defective CD3-mediated cell death in activated T-cells from patients with SLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2058 EP 2058 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86102286 ER PT J AU Millard, CB Lockridge, O Broomfield, CA AF Millard, CB Lockridge, O Broomfield, CA TI Butyrylcholinesterase G117H/E197Q is a somanase. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. UNIV NEBRASKA,MED CTR,EPPLEY CANC INST,OMAHA,NE 68198. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2217 EP 2217 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86102445 ER PT J AU Tolnay, M Lambris, JD Tsokos, GC AF Tolnay, M Lambris, JD Tsokos, GC TI Purification and characterization of a nuclear protein that binds to a CRE-like motif in the promoter region of the complement receptor-2 (CR2) gene. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV PENN,PHILADELPHIA,PA 19104. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2564 EP 2564 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86102792 ER PT J AU Saxena, A Redman, AMG Qian, NF Lockridge, I Doctor, BP AF Saxena, A Redman, AMG Qian, NF Lockridge, I Doctor, BP TI The role of alanine 328 in substrate activation and binding of inhibitors to butyrylcholinesterase. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. UNIV NEBRASKA,MED CTR,OMAHA,NE 68198. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2688 EP 2688 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86103112 ER PT J AU Ulrich, RG Brandler, P Dyas, B Sesno, J Saikh, K AF Ulrich, RG Brandler, P Dyas, B Sesno, J Saikh, K TI Comparison of exogenous and plasmid-mediated routes of vaccination for MHC class II-dependent antigens SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2726 EP 2726 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86102953 ER PT J AU Rao, M Rothwell, SW Wassef, NM Pagano, RE Alving, CR AF Rao, M Rothwell, SW Wassef, NM Pagano, RE Alving, CR TI Identification of the intracellular route followed by liposome-encapsulated conalbumin. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 2818 EP 2818 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86103051 ER PT J AU Wolfe, AD Truitt, B AF Wolfe, AD Truitt, B TI Pteridine displacement of Cibacron Blue 3GA from ricin SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 30 PY 1996 VL 10 IS 6 BP 3018 EP 3018 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UK861 UT WOS:A1996UK86103247 ER PT J AU Maier, RS Rohaly, TF Advani, SG Fickie, KD AF Maier, RS Rohaly, TF Advani, SG Fickie, KD TI A fast numerical method for isothermal resin transfer mold filling SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE RTM; control volume; free surface; porous medium; sparse matrix AB An efficient numerical scheme is presented For simulating isothermal how in resin transfer molding. The problem involves transient, free surface flow of an incompressible fluid into a non-deforming porous medium. A new variant of the Control Volume Finite Element (CVFE) algorithm is explained in detail. It is shown how the pressure solutions at each time step can be obtained by adding a single row and column to the Cholesky factorization of the stiffness matrix derived from a finite element formulation for the pressure field. This approach reduces the computation of a new pressure solution at each time step to essentially just two sparse matrix back-substitutions. The resulting performance improvement facilitates interactive simulation and the solution of inverse problems which require many simulations of the filling problem. The computational complexity of the calculation is bounded by O(n(2 . 5)), where n is the number of nodes in the finite element mesh. A 100-fold speedup over a conventional CVFE implementation was obtained for a 2213-node problem. C1 USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. UNIV DELAWARE,DEPT MECH ENGN,NEWARK,DE 19716. USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. RP Maier, RS (reprint author), MINNESOTA SUPERCOMP CTR INC,1100 WASHINGTON AVE SO,MINNEAPOLIS,MN 55415, USA. NR 13 TC 55 Z9 62 U1 1 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD APR 30 PY 1996 VL 39 IS 8 BP 1405 EP 1417 DI 10.1002/(SICI)1097-0207(19960430)39:8<1405::AID-NME910>3.0.CO;2-S PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA UG685 UT WOS:A1996UG68500007 ER PT J AU Chen, CJ Kurdak, C Tsui, DC Choi, KK AF Chen, CJ Kurdak, C Tsui, DC Choi, KK TI Separation of partition noise from generation-recombination noise in a three-terminal quantum well infrared photodetector SO APPLIED PHYSICS LETTERS LA English DT Article ID HOT-ELECTRON TRANSISTOR AB In this letter, we present results from our systematic study of the low frequency noise in an infrared hot-electron transistor. By measuring the correlation between emitter and collector noise currents, we are able to separate the partition noise and the generation-recombination (g-r) noise present in this three terminal device. Through the whole current range of more than two decades, the collector current noise S-Ic is always much larger than the cross-spectrum density between emitter and collector currents S-IeIc. We thus conclude that S-Ic comes mostly from the filtering process. (C) 1996 American Institute of Physics. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Chen, CJ (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08540, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 8 TC 1 Z9 1 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 29 PY 1996 VL 68 IS 18 BP 2535 EP 2537 DI 10.1063/1.116175 PG 3 WC Physics, Applied SC Physics GA UG866 UT WOS:A1996UG86600025 ER PT J AU Yun, SH Wu, JZ Tidrow, SC Eckart, DW AF Yun, SH Wu, JZ Tidrow, SC Eckart, DW TI Growth of HgBa2Ca2Cu3O8+delta thin films on LaAlO3 substrates using fast temperature ramping Hg-vapor annealing SO APPLIED PHYSICS LETTERS LA English DT Article ID SUPERCONDUCTIVITY AB The fast temperature ramping Hg-vapor annealing (FTRA) process has been used for growth of superconducting Hg-based cuprate thin films on (100) LaAlO3 substrates. The film/substrate interface chemical reactions and the formation of a CaHgO2 impurity phase have been effectively reduced with adoption of the FTRA process. A zero-resistance superconducting transition temperature of 128 K and critical current densities of up to 1.4 x 10(6) A/cm(2) at 77 K and 2.5 x 10(5) A/cm(2) at 110 K and zero field have been obtained. (C) 1996 American Institute of Physics. C1 UNIV KANSAS,DEPT PHYS & ASTRON,LAWRENCE,KS 66045. USA,RES LAB,FT MONMOUTH,NJ 07703. RI Tidrow, Steven/C-8133-2013 NR 9 TC 46 Z9 46 U1 0 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 29 PY 1996 VL 68 IS 18 BP 2565 EP 2567 DI 10.1063/1.116185 PG 3 WC Physics, Applied SC Physics GA UG866 UT WOS:A1996UG86600035 ER PT J AU Looareesuwan, S Olliaro, P Kyle, D Wernsdorfer, W AF Looareesuwan, S Olliaro, P Kyle, D Wernsdorfer, W TI Pyronaridine SO LANCET LA English DT Letter C1 UNDP,WORLD BANK,WHO,SPECIAL PROGRAMME RES & TRAINING,GENEVA,SWITZERLAND. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV VIENNA,INST SPEZIF PROPHYLAXE & TROP MED,VIENNA,AUSTRIA. RP Looareesuwan, S (reprint author), MAHIDOL UNIV,FAC TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 5 TC 6 Z9 6 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 27 PY 1996 VL 347 IS 9009 BP 1189 EP 1190 DI 10.1016/S0140-6736(96)90649-2 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA UG755 UT WOS:A1996UG75500055 PM 8609791 ER PT J AU Avery, MA Fan, PC Karle, JM Bonk, JD Miller, R Goins, DK AF Avery, MA Fan, PC Karle, JM Bonk, JD Miller, R Goins, DK TI Structure-activity relationships of the antimalarial agent artemisinin .3. Total synthesis of (+)-13-carbaartemisinin and related tetra- and tricyclic structures SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID LACTATE-DEHYDROGENASE; PLASMODIUM-FALCIPARUM; QINGHAOSU; 1,2,4-TRIOXANES; CHEMISTRY; ANALOGS; INVITRO; DRUGS AB Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S, 5aS,6R,8aS,9R,12S)-10-deoxo-13-carbaartemisinin (19), (+)-10-deoxo-13-carbaartemisinin (21), and (+)-13-carbaartemisinin (4). Structure assignment to 19 and 21 was based on single-crystal X-ray crystallographic analysis. Tricyclic endoperoxide 20 was converted to methyl and benzyl ethers 23 and 24 and reduced to saturated analog 25 which was also converted to ethers 26 and 27. In vitro antimalarial screening of both tri- and tetracyclic analogs was conducted using the W-2 and D-6 clones of Plasmodium falciparum. Neither target 4 nor 21 displayed substantial antimalarial potency in vitro against P. falciparum, but the diastereomeric peroxide 19 possessed good antimalarial potency in vitro. Tricyclic analogs were uniformly impotent. Iron(II) bromide-promoted rearrangement of 21 gave, in 79% yield, the unique tetracyclic alcohol 35, while 19 provided ring-opened cyclohexanone 41 (39%) along with the tricyclic epoxide 42 (20%). Neither 41 nor 42 possessed in vitro antimalarial activity, suggesting that epoxide-like intermediates are not responsible for the mode of action of this subclass of antimalarials. Rearrangement of 10-deoxoartemisinin (43) with FeBr2 gave a major product (79%) not encountered in the rearrangement of artemisinin that resulted from unraveling of the tetracyclic system cyclohexanone 46. Minor amounts of 1,10-dideoxoartemisinin (49) (8%) were also produced in this reaction. C1 UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP Avery, MA (reprint author), UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677, USA. NR 40 TC 67 Z9 70 U1 0 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 26 PY 1996 VL 39 IS 9 BP 1885 EP 1897 DI 10.1021/jm950921y PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA UJ112 UT WOS:A1996UJ11200017 PM 8627612 ER PT J AU Crosland, RD AF Crosland, RD TI Differentiation agents enhance cholinergic characteristics of LA-N-2 human neuroblastoma cells SO LIFE SCIENCES LA English DT Article; Proceedings Paper CT Scientific Festschrift on Cholinergic and Related Mechanisms in Aging and Disease - A Tribute to Donald J Jenden, MD CY NOV 17-18, 1995 CL UNIV CALIF LOS ANGELES, LOS ANGELES, CA SP Loyola Univ Chicago Stritch Sch Med, Neurosci & Aging Inst HO UNIV CALIF LOS ANGELES DE acetylcholine; cholinergic metabolism; neurotrophic factors ID LINES AB LA-N-2, a cell line derived from a human peripheral neuroblastoma, has a partially cholinergic phenotype and is a potential in vitro model of cholinergic neurons. The object of this study was to enhance the cholinergic phenotype of these cells with differentiation agents to improve the cell line's usefulness as a convenient model of cholinergic function. I treated cells in the presence of serum with 10 mu M 5-azacytidine, 2.5 mu M bromodeoxyuridine, 2 nM ciliary neurotrophic factor, 1 mM dibutyryl cAMP, 0.25 nM leukemia inhibitory factor and/or 3.8 nM nerve growth factor, N-2 supplement (without serum), or 10 mu M retinoic acid for 9-14 days. Treated cells were loaded with [H-3]choline for 30 min at 37 degrees and washed. The amounts of cellular and released (5 min, room temperature), labeled and unlabeled acetylcholine and choline were determined by HPLC. None of the differentiation agents induced Ca2+-dependent release of [H-3]acetylcholine, but 5-azacytidine, dibutyryl cAMP, N-2, and retinoic acid increased Ca2+-independent release that was specific for acetylcholine. In addition, 5-azacytidine, bromodeoxyuridine, leukemia inhibitory factor, and N-2 substantially increased [H-3]acetylcholine levels, and these increases correlated highly with increases in total acetylcholine levels. Overall, LA-N-2 cells should prove to be a good model for studying cholinergic function. RP Crosland, RD (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 12 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PD APR 26 PY 1996 VL 58 IS 22 BP 1987 EP 1994 DI 10.1016/0024-3205(96)00189-0 PG 8 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA UH285 UT WOS:A1996UH28500012 PM 8637428 ER PT J AU Person, DA AF Person, DA TI Gloves and socks syndrome SO LANCET LA English DT Letter ID AUSTRALIA ANTIGEN; POLYARTERITIS RP Person, DA (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 20 PY 1996 VL 347 IS 9008 BP 1125 EP 1126 DI 10.1016/S0140-6736(96)90328-1 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA UG042 UT WOS:A1996UG04200074 PM 8602104 ER PT J AU Krasko, GL AF Krasko, GL TI New method of evaluating the explicit magnetic-state-dependent energy of iron in semiempirical calculations SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 40th Annual Conference on Magnetism and Magnetic Materials CY NOV 06-09, 1995 CL PHILADELPHIA, PA SP Amer Inst Phys, IEEE, Magnet Soc, Minerals Met & Mat Soc, Amer Soc Testing & Mat, USN, Off Naval Res, Amer Ceram Soc ID DENSITY FUNCTIONAL FORMALISM; FCC IRON; TRANSITION-METALS; BCC AB The existing semiempirical methods for use in atomic computer simulations in iron (such as various modifications of the embedded atom method) have not explicitly taken account of the ferromagnetism per se. Rather, the adjustable parameters have simply been fitted to mechanical and thermal properties of bcc iron as a ferromagnetic phase. However, when the magnetic properties are essential in affecting localized atomic behavior (e.g., in the vicinity of crystal defects), these methods may be inadequate. To remedy the situation, a procedure is suggested for explicitly calculating the magnetic contribution to the energy of individual atoms, as a function of their atomic environment. The method uses the Stoner approach, as previously developed, and a data base obtained by the ab initio calculations on bcc Fe under hydrostatic and tetragonal deformations, and the (111) Fe free surface. The procedure may be incorporated in any semiempirical method: the ferromagnetic contributions to the bulk moduli, C-11, C-12, and C-44 are easily calculated and may be used subsequently in adjusting the semiempirical method parameters. Preliminary testing shows a good agreement with the magnetic properties obtained by our ab initio calculations. RP Krasko, GL (reprint author), USA,RES LAB,MAT DIRECTORATE,AMSRL,MA,CC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 12 TC 7 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1996 VL 79 IS 8 BP 4682 EP 4684 DI 10.1063/1.361703 PN 2A PG 3 WC Physics, Applied SC Physics GA UG877 UT WOS:A1996UG87700074 ER PT J AU Leupold, HA Tilak, AS Potenziani, E AF Leupold, HA Tilak, AS Potenziani, E TI Imposition of periodic magnetization patterns on high-energy-product magnetic plates SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 40th Annual Conference on Magnetism and Magnetic Materials CY NOV 06-09, 1995 CL PHILADELPHIA, PA SP Amer Inst Phys, IEEE, Magnet Soc, Minerals Met & Mat Soc, Amer Soc Testing & Mat, USN, Off Naval Res, Amer Ceram Soc AB Periodically magnetized permanent magnet plates with high-energy products are potentially very useful in high-field structures such as free-electron lasers, electrical machinery, and various mechanical applications such as magnetic bearings, for which they are already being used. A major problem is the lack of field sources with sufficient held amplitude to impose such patterns of magnetization on high-coercivity materials. This paper shows how such high amplitudes can be obtained for several patterns by use of modified sources of the augmented ''magic ring'' and ''magic sphere'' types. RP Leupold, HA (reprint author), USA,RES LAB,AMSRL PS PC,FT MONMOUTH,NJ 07703, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1996 VL 79 IS 8 BP 5551 EP 5553 DI 10.1063/1.362305 PN 2A PG 3 WC Physics, Applied SC Physics GA UG877 UT WOS:A1996UG87700407 ER PT J AU Lytle, VI Ackley, SF AF Lytle, VI Ackley, SF TI Heat flux through sea ice in the western Weddell Sea: Convective and conductive transfer processes SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID MIXED LAYER; MODEL AB The heat flux through the snow and sea ice cover and at the ice/ocean interface were calculated at five sites in the western Weddell Sea during autumn and early winter 1992. The ocean heat Bur averaged 7 +/- 2 W/m(2) from late February to early June, and average ice/air heat flux in the second-year floes depended on the depth of the snow cover and ranged from 9 to 17 (+/- 0.8) W/m(2). In late February, three of the five sites had an ice surface which was depressed below sea level, resulting, at two of the sites, in a partially flooded snow cover and a slush layer at the snow/ice interface. As this slush layer froze to form snow ice, the dense brine which was rejected flowed out through brine drainage channels and was replaced by lower-salinity, nutrient-rich seawater from the ocean upper layer. We estimate that about half of the second-year ice in the region was covered with this slush layer early in the winter. As the slush layer froze, over a 2- to 3-week period, the convection within the ice transported salt from the ice to the upper ocean and increased total heat flux through the overlying ice and snow cover. On an areawide basis, approximately 10 cm of snow ice growth occurred within second-year pack ice, primarily during a 2- to 3-week period in February and March. This ice growth, near the surface of the ice, provides a salt flux to the upper ocean equivalent to 5 cm of ice growth, despite the thick (about 1 m) ice cover, in addition to the ice growth in the small (area less than 5%), open water regions. C1 COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP Lytle, VI (reprint author), UNIV TASMANIA,ANTARCTIC COOPERAT RES CTR,HOBART,TAS 7001,AUSTRALIA. NR 28 TC 93 Z9 93 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD APR 15 PY 1996 VL 101 IS C4 BP 8853 EP 8868 DI 10.1029/95JC03675 PG 16 WC Oceanography SC Oceanography GA UG511 UT WOS:A1996UG51100008 ER PT J AU Videen, G Ngo, D Hart, MB AF Videen, G Ngo, D Hart, MB TI Light scattering from a pair of conducting, osculating spheres SO OPTICS COMMUNICATIONS LA English DT Article DE scattering; diffraction ID CLASSICAL ELECTROMAGNETIC SCATTERING; CONSUMMATE SOLUTION; ABSORPTION; PARTICLES; CLUSTERS; ENSEMBLE; CHAINS AB The fields from a system composed of two conducting, osculating spheres are derived using an extension of Mie theory. The boundary conditions are satisfied on both surfaces by expanding the fields in terms of vector spherical harmonics and translating them between the coordinate systems of the two spheres. We give explicit expressions for the far-field and the cross-sections. Order-of-scatter methods diverge when finding the scattered field coefficients, so the coefficients must be found directly. Splittings are discovered in the solutions of the scattered field, and we find very good agreement between the average of the solutions with experimental microwave backscatter measurements. C1 NEW MEXICO STATE UNIV, DEPT PHYS, LAS CRUCES, NM 88003 USA. EDGEWOOD RES & DEV ENGN CTR, ABERDEEN PROVING GROUND, MD 21010 USA. RP Videen, G (reprint author), USA, RES LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. NR 30 TC 18 Z9 18 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD APR 15 PY 1996 VL 125 IS 4-6 BP 275 EP 287 DI 10.1016/0030-4018(95)00738-5 PG 13 WC Optics SC Optics GA UJ921 UT WOS:A1996UJ92100015 ER PT J AU Artenstein, AW Hegerich, PA Beyrer, C Rungruengthanakit, K Michael, NL Natpratan, C AF Artenstein, AW Hegerich, PA Beyrer, C Rungruengthanakit, K Michael, NL Natpratan, C TI Sequences and phylogenetic analysis of the nef gene from Thai subjects harboring subtype E HIV-1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. ROYAL THAI MINIST PUBL HLTH,DEPT COMMUNICABLE DIS CONTROL,CHIANG MAI 50200,THAILAND. CHIANG MAI UNIV,RES INST HLT SCI,CHIANG MAI 50200,THAILAND. RP Artenstein, AW (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850, USA. NR 12 TC 14 Z9 14 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR 10 PY 1996 VL 12 IS 6 BP 557 EP 560 DI 10.1089/aid.1996.12.557 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA UD625 UT WOS:A1996UD62500013 PM 8679312 ER PT J AU YarrisonRice, JM Sharp, EJ Wood, GL Neurgaonkar, RR AF YarrisonRice, JM Sharp, EJ Wood, GL Neurgaonkar, RR TI Edge enhancement of a phase-conjugate image with a mutually pumped phase conjugator SO APPLIED OPTICS LA English DT Article ID SPATIAL AMPLIFICATION; CRYSTALS AB Usually edge enhancement of optical images is produced by introduction of loss into the low spatial frequency components of the image-bearing beam in the Fourier plane of a lens. We report on edge-enhanced phase-conjugate images from a mutually pumped conjugator accomplished by spatial filtering in the Fraunhofer diffraction region of the input beams. High-resolution (128-160 lines/mm) edge-enhanced images are obtained through traditional spatial filtering in the Fourier plane and in the Fraunhofer regime. Amplification of these edge-enhanced images is observed with some loss of high spatial resolution (50 lines/mm). (C) 1996 Optical Society of America C1 USA, RES LAB, FT BELVOIR, VA 22060 USA. ROCKVILLE INT SCI CTR, THOUSAND OAKS, CA 91358 USA. RP YarrisonRice, JM (reprint author), MIAMI UNIV, DEPT PHYS, OXFORD, OH 45056 USA. NR 24 TC 2 Z9 2 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 10 PY 1996 VL 35 IS 11 BP 1904 EP 1910 DI 10.1364/AO.35.001904 PG 7 WC Optics SC Optics GA UD301 UT WOS:A1996UD30100012 PM 21085315 ER PT J AU Pai, SV Chabalowski, CF Rice, BM AF Pai, SV Chabalowski, CF Rice, BM TI Ab initio study of reactions of sym-triazine SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID GAUSSIAN-BASIS SETS; CORRELATED MOLECULAR CALCULATIONS; ORBITAL METHODS; WAVE-FUNCTIONS; ATOMS; DYNAMICS; HYDROGEN; ISOMERS AB Ab initio calculations were performed to investigate reaction mechanisms for formation and decomposition of the six-membered ring C3N3H3, known as sym-triazine. MP2 geometry optimizations with QCISD(T) energy refinements for critical points on the potential energy surface were calculated with the 6-31G** 6-311++G** and cc-pVTZ basis sets. Good agreement is found for MP2 geometries and frequencies of sym-triazine and HCN when compared with the corresponding experimental values. Two decomposition mechanisms of sym-triazine, the concerted triple dissociation (sym-triazine --> 3 HCN) and the stepwise decomposition (sym-triazine --> H2C2N2 + HCN --> 3 HCN) were investigated. All calculations show that the lowest energy decomposition mechanism is the concerted triple dissociation. Our best calculations predict the zero-point-energy-corrected barrier to decomposition to be 81.2 kcal/mol. The calculated reaction enthalpy is 35.5 kcal/mol, 7.7 kcal/mol lower than experiment. Intrinsic reaction coordinate calculations leading from the transition state of the concerted triple dissociation reaction to three HCN molecules led to a minimum on the potential energy surface. The corresponding structure is a cyclic (HCN)(3) cluster. The temperature-corrected formation enthalpy of the cluster is -8.7 kcal/mol relative to three isolated HCN molecules. The zero-point-corrected barrier to formation of sym-triazine from the cluster is 58.1 kcal/mol. QCISD(T) energy refinements did not differ significantly from the MP2 results. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 24 TC 22 Z9 22 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD APR 4 PY 1996 VL 100 IS 14 BP 5681 EP 5689 DI 10.1021/jp9532778 PG 9 WC Chemistry, Physical SC Chemistry GA UD604 UT WOS:A1996UD60400015 ER PT J AU Waag, DM Williams, JC AF Waag, DM Williams, JC TI Changes in spleen and thymus cell phenotypes in mice vaccinated with the Coxiella burnetii phase I whole-cell vaccine or the chloroform-methanol residue subunit vaccine SO ACTA VIROLOGICA LA English DT Article DE Q fever; vaccine; immunity; leukocyte phenotypes ID Q-FEVER; IMMUNITY AB Lymphoid cell phenotypes within the spleen and thymus were analyzed to determine whether numerical or proportional changes in cell populations could account for the immunosuppression seen after vaccination of mice with inactivated phase I Coxiella burnetii whole-cell vaccine (WCI). Within 21 days of vaccination with WCI, there was a reduction in the percentage of splenic T cells and B cells while the numbers of thymic T cells and B cells increased. A substantial percentage of spleen cells did not bear typical T cell or B cell surface markers. In contrast, except for an early rise (by day 3) in the numbers of T and B cells, injecting the chloroform-methanol residue subunit vaccine (CMR) caused no significant phenotypic changes of lymphoid cells in the spleen or thymus. The percentage of thymus cells bearing T cell phenotypes was similar in mice vaccinated with WCI or CMR. However, the total number of T cells in the thymus dramatically decreased in mice vaccinated with WCI. There was no correlation between the lymphocyte hyporesponsiveness to mitogens and WCI in vitro and the increased numbers of CD8-positive splenocytes. These results suggest that WCI vaccination caused dramatic changes in splenocyte and thymocyte lymphocyte populations and provide evidence for the more benign nature of the CMR vaccine. RP Waag, DM (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,PATHOGENESIS & IMMUNOL BRANCH,FREDERICK,MD 21702, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU SLOVAK ACADEMIC PRESS LTD PI BRATISLAVA PA PO BOX 57, NAM SLOBODY 6, 810 05 BRATISLAVA, SLOVAKIA SN 0001-723X J9 ACTA VIROL JI Acta Virol. PD APR PY 1996 VL 40 IS 2 BP 87 EP 94 PG 8 WC Virology SC Virology GA UY097 UT WOS:A1996UY09700005 PM 8886117 ER PT J AU Larson, HM OConnor, FG Nirschl, RP AF Larson, HM OConnor, FG Nirschl, RP TI Shoulder pain: The role of diagnostic injections SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID SOFT-TISSUE; GUIDELINES; JOINTS AB Many different shoulder disorders cause similar symptoms and pain patterns. An accurate diagnosis can generally be made by obtaining a detailed history, performing a comprehensive, directed physical examination and obtaining selected radiographs. Occasionally, shoulder injections can be of great assistance in establishing a clear diagnosis and providing relief of symptoms. Subacromial space injection, acromioclavicular joint injection, intra-articular injection and injection of the biceps tendon are helpful in identifying such disorders as subacromial bursitis, acromioclavicular arthritis, injury to the glenohumeral joint and bicipital tendinitis. C1 MUNSON ARMY COMMUNITY HOSP,FT LEAVENWORTH,KS. DEWITT ARMY COMMUNITY HOSP,FT BELVOIR,VA. NIRSCHL ORTHOPED & SPORTS MED CTR,ARLINGTON,VA. NR 10 TC 13 Z9 13 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR PY 1996 VL 53 IS 5 BP 1637 EP 1643 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA UE743 UT WOS:A1996UE74300020 PM 8623691 ER PT J AU Hartman, KR Barker, JA AF Hartman, KR Barker, JA TI Microcytic anemia with iron malabsorption: An inherited disorder of iron metabolism SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE erythropoiesis; red blood cell disorders; iron metabolism; iron malabsorption ID DEFICIENCY; ABSORPTION; CHILDREN AB Two siblings were identified with severe hypoproliferative microcytic anemia and iron malabsorption, in the absence of any gastrointestinal disorder or blood loss. These children had severe microcytosis (MCV 48 fl, hemoglobin 7.5 g/dl) with decreased serum iron, elevated serum TIBC, and decreased serum ferritin, despite prolonged treatment with oral iron. An iron challenge study with an oral dose of 2 mg/kg elemental iron as ferrous sulfate documented iron malabsorption, After treatment with intravenous iron dextran, there was an absence of the expected reticulocytosis and only a partial correction of the hemoglobin, hematocrit, and microcytosis. The bone marrow was hypocellular with abnormal iron incorporation into erythroid precursor cells, This appears to be a rare form of inherited anemia characterized by iron malabsorption and disordered iron metabolism that only partially corrects after the administration of parenteral iron. These features resemble those found in the microcytic mouse (mk/mk), which also has severe microcytic anemia and iron malabsorption that partially responds to parenteral iron, (C) 1996 Wiley-Liss, Inc.* C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP Hartman, KR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,MED RES FELLOWSHIP,WASHINGTON,DC 20307, USA. NR 18 TC 44 Z9 47 U1 1 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD APR PY 1996 VL 51 IS 4 BP 269 EP 275 DI 10.1002/(SICI)1096-8652(199604)51:4<269::AID-AJH4>3.0.CO;2-U PG 7 WC Hematology SC Hematology GA UC620 UT WOS:A1996UC62000004 PM 8602626 ER PT J AU Mills, JN Oro, JGB Bressler, DS Childs, JE Tesh, RB Smith, JF Enria, DA Geisbert, TW McKee, KT Bowen, MD Peters, CJ Jahrling, PB AF Mills, JN Oro, JGB Bressler, DS Childs, JE Tesh, RB Smith, JF Enria, DA Geisbert, TW McKee, KT Bowen, MD Peters, CJ Jahrling, PB TI Characterization of oliveros virus, a new member of the tacaribe complex (Arenaviridae: Arenavirus) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ARGENTINE HEMORRHAGIC-FEVER; NUCLEOCAPSID PROTEIN GENE; JUNIN; SEQUENCE; RODENTS; AREAS AB Oliveros virus is an agent isolated in cell culture from Bolomys obscurus (Rodentia, Muridae, Sigmodontinae) captured on the central Argentine pampa. Oliveros virus was shown to be related to members of the Tacaribe complex of the family Arenaviridae by immunofluorescent antibody (IFA) tests, electrophoretic pattern of viral proteins, and morphology as observed by electron microscopy. It was distinct from 12 other arenaviruses by a combination of plaque-reduction neutralization tests, comparison of endpoint titers among cross-IFA tests, and comparison of viral RNA sequence data. This agent is the third new arenavirus from South America described within the last three years. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. INST NACL ENFERMEDADES VIRALES HUMANAS,PERGAMINO 2700,ARGENTINA. WOMACK ARMY MED CTR,COMMUNICABLE DIS UNIT,FT BRAGG,NC 28307. YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,YALE ARBOVIRUS RES UNIT,NEW HAVEN,CT 06510. RP Mills, JN (reprint author), CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,MAILSTOP G-13,1600 CLIFTON RD,ATLANTA,GA 30333, USA. RI Childs, James/B-4002-2012 NR 29 TC 22 Z9 24 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1996 VL 54 IS 4 BP 399 EP 404 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA UJ490 UT WOS:A1996UJ49000017 PM 8615455 ER PT J AU Ramos, BL Choquette, SJ Fell, NF AF Ramos, BL Choquette, SJ Fell, NF TI Embossable grating couplers for planar waveguide optical sensors SO ANALYTICAL CHEMISTRY LA English DT Article ID WAVE-GUIDES; THIN-FILMS; IMMUNOSENSOR AB Planar optical waveguides are an attractive tool for use in analytical chemistry and spectroscopy. Although similar to fiber optics, planar waveguides have been slow to be commercially accepted due to the difficulty of coupling light into the guide. Generally, prism coupling is the method of choice in the laboratory, as efficiencies approaching 80% can be reached. However, prisms are impractical for routine use for several reasons: expensive positioning equipment is required, coupled power is sensitive to environmental fluctuations, and prism coupling prohibits the fabrication of a truly planar device. The use of thin gratings on the surface of the waveguide allows for a two-dimensional structure to be maintained, while providing enough efficiency to be useful as a sensor. Our research efforts focus on developing a technique to make inexpensive, reproducible gratings that are easy to fabricate. By chemically modifying the surface of a commercial grating with a suitable release agent, it is possible to emboss replica gratings onto a variety of waveguide types. The fabrication of embossed gratings will be described, and their performance on glass, ion-diffused, polymer, and semiconductor waveguides will be presented. C1 NATL INST STAND & TECHNOL,DIV ANALYT CHEM,GAITHERSBURG,MD 20899. USA,RES LAB,IGNIT & COMBUST BRANCH,ABERDEEN PROVING GROUND,MD 21005. NR 24 TC 19 Z9 20 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD APR 1 PY 1996 VL 68 IS 7 BP 1245 EP 1249 DI 10.1021/ac950579x PG 5 WC Chemistry, Analytical SC Chemistry GA UC182 UT WOS:A1996UC18200033 PM 21619155 ER PT J AU Karan, SM Lojeski, EW Haynes, DH Bina, S Wesche, DL Boedeker, BH Muldoon, SM AF Karan, SM Lojeski, EW Haynes, DH Bina, S Wesche, DL Boedeker, BH Muldoon, SM TI Intravenous lecithin-coated microcrystals of dantrolene are effective in the treatment of malignant hyperthermia: An investigation in rats, dogs, and swine SO ANESTHESIA AND ANALGESIA LA English DT Article ID DOSE-RESPONSE AB Dantrolene effectively treats malignant hyperthermia (MH) but the current form, Dantrium(R), must be dissolved to a 0.33 mg/mL, pH 9.5 solution. This study describes lecithin-coated microcrystal formulations of sodium dantrolene (MC-NaD) and neutral dantrolene (MC-D) which reconstitute to 200 mg/mL within 1 min. In rats, the pharmacokinetics and pharmacodynamics of MC-NaD and Dantrium(R) were similar: half-lives of 3.1 h, volume of distributions of 0.54 and 0.59 L/kg, and 95% effective dose (ED(95)) values for depression of skeletal muscle twitch height (ED(95)T) of 2.6 +/- 0.7 and 2.8 +/- 0.5 mg/kg. In swine, the ED(95)T values for MC-NaD and Dantrium(R) were also similar (2.8 +/- 0.4 vs 2.7 +/- 0.6 mg/kg), but MC-D and Dantrium(R) were only similar at doses more than 2.5 mg/kg (ED(95)T: 3.5 +/- 0.4 vs 2.7 +/- 0.5 mg/kg). In susceptible swine, MC-NaD successfully treated five of six MH episodes and prevented MH in three of four swine. However, MC-NaD caused marked pulmonary hypertension in swine, while MC-D caused only a mild response that was eliminated by filtration. Likewise, MC-D caused no pulmonary response in dogs. These observations suggest that MC-D has potential to improve the treatment of MH. C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. PHARMA LOG INC,MIAMI,FL. RP Karan, SM (reprint author), USUHS,DEPT ANESTHESIOL,F EDWARD HEBERT SCH MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 10 TC 10 Z9 11 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD APR PY 1996 VL 82 IS 4 BP 796 EP 802 DI 10.1097/00000539-199604000-00021 PG 7 WC Anesthesiology SC Anesthesiology GA UC482 UT WOS:A1996UC48200021 PM 8615500 ER PT J AU Rothenberg, ML Moore, MJ Cripps, MC Andersen, JS Portenoy, RK Burris, HA Green, MR Tarassoff, PG Brown, TD Casper, ES Storniolo, AM VonHoff, DD Alberts, DS Wolff, R Kelsen, DP Kocha, W Haller, DG ModianoRevah, M Moore, M Oken, MM Schilsky, RL Shah, A AF Rothenberg, ML Moore, MJ Cripps, MC Andersen, JS Portenoy, RK Burris, HA Green, MR Tarassoff, PG Brown, TD Casper, ES Storniolo, AM VonHoff, DD Alberts, DS Wolff, R Kelsen, DP Kocha, W Haller, DG ModianoRevah, M Moore, M Oken, MM Schilsky, RL Shah, A TI A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer SO ANNALS OF ONCOLOGY LA English DT Article DE chemotherapy; clinical benefit; gemcitabine; pancreas cancer; quality of life ID 2',2'-DIFLUORODEOXYCYTIDINE; CELLS; PAIN AB Purpose: To assess the effect of gemcitabine in patients with metastatic pancreas cancer that had progressed despite prior treatment with 5-FU. Patients and methods: Seventy-four patients were enrolled in this multicenter trial. Alleviation of cancer-related symptoms was the primary endpoint. Sixty-three patients completed a pain stabilization period and were treated with gemcitabine. Clinical Benefit Response was defined as a greater than or equal to 50% reduction in pain intensity, greater than or equal to 50% reduction in daily analgesic consumption, or greater than or equal to 20 point improvement in KPS that was sustained for greater than or equal to 4 consecutive weeks. Results: Seventeen of 63 pts (27.0%) attained a Clinical Benefit Response (95% CI: 16.0%-38.0%). The median duration of Clinical Benefit Response was 14 weeks (range: 4-69 weeks). Median survival for patients treated with gemcitabine was 3.85 months (range: 0.3-18.0+ months). Therapy was generally well-tolerated with a low incidence of grade 3 or 4 toxicities. Conclusion: Systematic assessment of subjective outcomes can be used to evaluate the clinical impact of new therapies for pancreas cancer, a highly symptomatic disease. Our findings suggest that gemcitabine is a useful palliative agent in patients with 5-FU-refractory pancreas cancer. C1 CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. PRINCESS MARGARET HOSP,TORONTO,ON M4X 1K9,CANADA. OTTAWA REG CANC CTR,OTTAWA,ON K1Y 4K7,CANADA. ELI LILLY & CO,LILLY RES LABS,INDIANAPOLIS,IN 46285. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV CALIF SAN DIEGO,CTR CANC,SAN DIEGO,CA. DUKE UNIV,MED CTR,DURHAM,NC. RP Rothenberg, ML (reprint author), UNIV TEXAS,HLTH SCI CTR,DIV MED ONCOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. RI qiao, zhixin/I-3408-2012 NR 17 TC 465 Z9 474 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD APR PY 1996 VL 7 IS 4 BP 347 EP 353 PG 7 WC Oncology SC Oncology GA UT903 UT WOS:A1996UT90300015 PM 8805925 ER PT J AU DiPiro, CV Dudukovich, L Sims, JJ AF DiPiro, CV Dudukovich, L Sims, JJ TI Albumin prophylaxis of ovarian hyperstimulation syndrome SO ANNALS OF PHARMACOTHERAPY LA English DT Review ID HIGH-RISK; PREVENTION C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT FAMILY & COMMUNITY MED,FT GORDON,GA. UNIV KENTUCKY,MED CTR,LEXINGTON,KY. RP DiPiro, CV (reprint author), MED COLL GEORGIA,AMBULATORY ONCOL SERV,DEPT PHARM,BIW-201,1120 15TH ST,AUGUSTA,GA 30912, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD APR PY 1996 VL 30 IS 4 BP 402 EP 404 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UE201 UT WOS:A1996UE20100015 PM 8729897 ER PT J AU Kelemen, JJ Cioffi, WG Mason, AD Mozingo, DW McManus, WF Pruitt, BA AF Kelemen, JJ Cioffi, WG Mason, AD Mozingo, DW McManus, WF Pruitt, BA TI Effect of ambient temperature on metabolic rate after thermal injury SO ANNALS OF SURGERY LA English DT Article ID HYPERMETABOLIC RESPONSE AB Objective The authors describe the effect of ambient temperature on metabolic rate after thermal injury. Summary Background Data Thermal injury induces a hypermetabolic state, which is reported to increase with the extent of burn. The magnitude of this response is further influenced by ambient temperature. Methods The resting energy expenditure was measured by indirect calorimetry at ambient temperatures of 22, 28, 32, and 35 C. It was indexed to a calculated basal metabolic rate in normal volunteers and adult patients with burns involving at least 20% of the total body surface area who had no evidence of systemic infection. These measurements were performed between postburn days 6 and 21. Results The effect of ambient temperature on metabolic rate was measured in 44 burn patients and 8 normal volunteers. Burn size ranged from 20 to 97% total body surface area with a mean of 44 +/- 18.5% total body surface area. Metabolic rate did not change significantly in control subjects as ambient temperature was varied (p < 0.05). Regression analysis showed that burn size and ambient temperature were significant determinants (p < 0.01) of metabolic rate in the patients and that together these factors accounted for 55% of the variation observed (df adj. r(2) = 0.55) across the range of ambient temperatures studied. Metabolic rate was independent of burn size at ambient temperatures of 32 and 35 C (p < 0.02) and increased by a factor of 1.5 X basal metabolic rate. A further increase in metabolic rate, which was positively correlated with burn size, resulted from nonshivering thermogenesis at ambient temperatures 28 and 22 C. The magnitude of this response was greatest at 22 C. Conclusions These findings suggest that the hypermetabolic response to thermal injury is maximal in burns as small as 20% total body surface area and that an additional burn size-dependent increase in metabolic rate results from heat loss at ambient temperatures below thermoneutrality. C1 BROOKE ARMY MED CTR,DEPT GEN SURG,FT SAM HOUSTON,TX 78234. BROWN UNIV,DIV TRAUMA,PROVIDENCE,RI. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 16 TC 18 Z9 18 U1 0 U2 3 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD APR PY 1996 VL 223 IS 4 BP 406 EP 412 DI 10.1097/00000658-199604000-00009 PG 7 WC Surgery SC Surgery GA UE698 UT WOS:A1996UE69800009 PM 8633919 ER PT J AU Callahan, HL Kelley, C Pereira, T Grogl, M AF Callahan, HL Kelley, C Pereira, T Grogl, M TI Microtubule inhibitors: Structure-activity analyses suggest rational models to identify potentially active compounds SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTITUBULIN HERBICIDE TRIFLURALIN; DINITROANILINE-RESISTANT ELEUSINE; PROTOZOAN LEISHMANIA-MEXICANA; POLYMERIZATION INVITRO; DRUG-RESISTANCE; ORYZALIN; TUBULIN; INVIVO AB Trifluralin, a dinitroaniline microtubule inhibitor currently in use as an herbicide, has been shown to inhibit the proliferation of Plasmodium falciparum, Trypanosoma brucei, and several species of Leishmania, in vitro, As a topical formulation, trifluralin is also effective in vivo (in BALB/c mice) against Leishmania major and Leishmania mexicana. Although trifluralin and other dinitroaniline herbicides show significant activity as antiparasitic compounds, disputed indications of potential carcinogenicity will probably limit advanced development of these substances. However, researchers have suggested that the activity of trifluralin is due to an impurity or contaminant, not to trifluralin itself. We have pursued this lead and identified the structure of the active impurity, This compound, chloralin, is 100 times more active than trifluralin. On the basis of its structure, we developed a rational structure-activity model for chloralin, Using this model, we have successfully predicted and tested active analogs in a Leishmania promastigote assay; thus, we have identified the putative mechanism of action of this class of drugs in Leishmania species. Potentially, this will allow the design of noncarcinogenic, active drugs. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP Callahan, HL (reprint author), USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO DE JANEIRO,APO,AA 34030, USA. NR 40 TC 47 Z9 48 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 1996 VL 40 IS 4 BP 947 EP 952 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA UD248 UT WOS:A1996UD24800023 PM 8849257 ER PT J AU Engell, D Kramer, M Malafi, T Salomon, M Lesher, L AF Engell, D Kramer, M Malafi, T Salomon, M Lesher, L TI Effects of effort and social modeling on drinking in humans SO APPETITE LA English DT Article ID FLUID INTAKE; FOOD CHOICE; THIRST; CONSUMPTION; ECONOMICS; BEHAVIOR; WATER AB The role of economic and social influences on water intake in humans was explored in two experiments. In the first experiment, the effect of water cost (as defined as the amount of effort required to acquire water) on prandial drinking was studied by manipulating water position during an ad libitum meal: water was available either on the dining table, about 20 feet from the table, or approximately 40 feet away. Subjects drank significantly more when the water was on the table than in the other conditions; but a linear relationship between cost (distance) and intake was not observed. In the second experiment, the effects of water cost and a social model on drinking were assessed in a similar paradigm. Increasing effort required to obtain water significantly reduced prandial water intake, and the presence of a social model increased water intake. Although some interesting trends emerged, no significant interactions between social and economic factors were found. These experiments demonstrate that environmental factors can significantly affect facultative drinking in humans. (C) 1996 Academic Press Limited RP Engell, D (reprint author), USA,NATICK RES DEV & ENGN CTR,BEHAV SCI DIV,NATICK,MA 01760, USA. NR 38 TC 27 Z9 28 U1 0 U2 5 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD APR PY 1996 VL 26 IS 2 BP 129 EP 138 DI 10.1006/appe.1996.0011 PG 10 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA UF021 UT WOS:A1996UF02100003 PM 8737165 ER PT J AU Biswas, R Strawn, RC AF Biswas, R Strawn, RC TI Mesh quality control for multiply-refined tetrahedral grids SO APPLIED NUMERICAL MATHEMATICS LA English DT Article ID UNSTRUCTURED MESHES AB A new algorithm for controlling the quality of multiply-refined tetrahedral meshes is presented in this paper. The basic dynamic mesh adaption procedure allows localized grid refinement and coarsening to efficiently capture aerodynamic flow features in computational fluid dynamics problems; however, repeated application of the procedure may significantly deteriorate the quality of the mesh. Results presented show the effectiveness of this mesh quality algorithm and its potential in the area of helicopter aerodynamics and acoustics. C1 NASA,AMES RES CTR,USA,AFDD,MOFFETT FIELD,CA 94035. RP Biswas, R (reprint author), NASA,AMES RES CTR,RIACS,MAIL STOP T27A-1,MOFFETT FIELD,CA 94035, USA. NR 8 TC 4 Z9 4 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9274 J9 APPL NUMER MATH JI Appl. Numer. Math. PD APR PY 1996 VL 20 IS 4 BP 337 EP 348 DI 10.1016/0168-9274(95)00099-2 PG 12 WC Mathematics, Applied SC Mathematics GA UT823 UT WOS:A1996UT82300003 ER PT J AU Carvalho, RM Yoshiyama, M Brewer, PD Pashley, DH AF Carvalho, RM Yoshiyama, M Brewer, PD Pashley, DH TI Dimensional changes of demineralized human dentine during preparation for scanning electron microscopy SO ARCHIVES OF ORAL BIOLOGY LA English DT Article DE shrinkage; tissue preparation; dentine ID PELDRI-II; RESIN; SYSTEMS; WATER AB Dentine rods measuring approx. 0.7 x 0.7 x 5.0 mm were prepared from the crowns of extracted human third molars. The specimens were demineralized in 0.5 M EDTA (pH 7.0) for 3 days and their volume measured with a digital micrometer under a dissecting microscope. The specimens were randomly assigned to experimental groups and were chemically dehydrated in acetone. Next they were dried using either hexamethyldisilazane, Peldri II, or critical-point drying techniques. The dimensions of the specimens were measured again after each step and the changes in volume were expressed as a percentage of the original demineralized volume. The effects of fixing the specimens in 10% buffered formalin before dehydration with acetone were also investigated for every drying procedure. Dehydration in acetone caused a small but significant reduction in the volume of demineralized formalin-fixed specimens but unfixed specimens did not change significantly. In general, all three drying procedures caused some shrinkage in demineralized dentine specimens. Unfixed specimens exhibited a volumetric shrinkage of approx. 15-20% after drying with any of the methods. Fixed specimens shrank more than unfixed specimens after drying (25-35%). Regardless of the drying technique, the specimens shrank a further 10-20% when measured in the vacuum chamber of the scanning electron microscope. Among the three drying techniques employed, hexamethyldisilazane seems to be a very useful alternative to critical-point drying for the preparation of dentine specimens for scanning electron microscopy. Copyright (C) 1996 Elsevier Science Ltd. C1 UNIV SAO PAULO,BAURU SCH DENT,DEPT OPERAT DENT,BR-17043101 BAURU,SP,BRAZIL. UNIV TOKUSHIMA,SCH DENT,DEPT CONSERVAT DENT,TOKUSHIMA 770,JAPAN. DWIGHT DAVID EISENHOWER MED CTR,DEPT CLIN INVEST,FT GORDON,GA. RP Carvalho, RM (reprint author), MED COLL GEORGIA,SCH DENT,DEPT ORAL BIOL PHYSIOL,AUGUSTA,GA 30912, USA. FU NIDCR NIH HHS [DE06427] NR 35 TC 46 Z9 47 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0003-9969 J9 ARCH ORAL BIOL JI Arch. Oral Biol. PD APR PY 1996 VL 41 IS 4 BP 379 EP 386 DI 10.1016/0003-9969(95)00130-1 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UN113 UT WOS:A1996UN11300008 PM 8771329 ER PT J AU Tsokos, GC Kovacs, B Sfikakis, PP Theocharis, S Vogelgesang, S Via, CS AF Tsokos, GC Kovacs, B Sfikakis, PP Theocharis, S Vogelgesang, S Via, CS TI Defective antigen-presenting cell function in patients with systemic lupus erythematosus - Role of the B7-1 (CD80) costimulatory molecule SO ARTHRITIS AND RHEUMATISM LA English DT Article ID T-CELL; RECEPTOR; EXPRESSION; ACTIVATION; MONOCYTES; NEPHRITIS; CRITERIA; LINES; BB-1; SLE AB Objective. Patients with systemic lupus erythematosus (SLE) who exhibit defective in vitro responses to recall antigens and normal responses to alloantigens have been shown to have an abnormality in antigen-presenting cell (APC) function, This study was undertaken to further characterize this defect in APC function in lupus patients. Methods. Mononuclear cells (MNC) from the peripheral blood of patients with SLE and from normal individuals were cultured in the presence of either recall antigen tetanus toroid (TT), anti-CD3 (OKT3) monoclonal antibody, or alloantigens, and proliferative or interleukin-2 responses were assessed. Cell surface expression of B7-1 was assessed by flow cytometry. Results. MNC from all normal individuals and from 7 patients with SLE responded to both TT and alloantigen and were designated +/+. Twelve SLE patients did not respond to TT but did respond to alloantigen stimulation and were designated -/+. In both normal subjects and SLE patients, the ability to respond to OKT3 correlated strongly with the ability to respond to recall antigen, A defect in APC costimulatory function was suggested by data demonstrating that interferon-gamma-induced expression of B7-1 was significantly reduced in SLE patients compared with controls. Neither controls nor SLE patients expressed detectable amounts of surface B7-1 molecule on resting APC. Defective recall and anti-CD3-stimulated responses could be enhanced in SLE patients in the presence of B7/BB1-transfected P815 murine mastocytoma cells underscoring an SLE-associated defect in costimulatory activity. However, nontransfected P815 cells were also able to enhance responses to OKT3 in -/+ patients; blocking experiments showed that this was mediated through an IgG Fc receptor-dependent mechanism. Conclusion. These data indicate that SLE-associated defects in APC function in vitro can be accounted for by abnormalities in APC surface membrane molecules such as B7, IgG Pc receptors, and possibly others. C1 VET ADM MED CTR,RES SERV,BALTIMORE,MD 21218. UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. RP Tsokos, GC (reprint author), WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307, USA. FU NIAID NIH HHS [R29-AI33882] NR 30 TC 42 Z9 46 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD APR PY 1996 VL 39 IS 4 BP 600 EP 609 DI 10.1002/art.1780390409 PG 10 WC Rheumatology SC Rheumatology GA UD638 UT WOS:A1996UD63800008 PM 8630108 ER PT J AU Mason, KT Harper, JP Shannon, SG AF Mason, KT Harper, JP Shannon, SG TI Herniated nucleus pulposus: Rates and outcomes among US Army aviators SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB The incidence and age-specific rates, and aeromedical dispositions of herniated nucleus pulposus (HNP) are unknown among U.S. Army aviators. The U.S. Army Aviation Epidemiology Data Register (AEDR) was queried for Army aviators with the finding of HNP for the period 1987 to 1992. This study tabulated the incidence, age-specific annual rates of HNP, and the distribution of aeromedical dispositions for aircrew with HNP. The U.S. Army aviation medicine community can expect an annual incidence rate about 1 case of HNP per 1,000 aviator-years. However, the annual incidence rate per 1,000 aviator-years increased significantly by fivefold from 0.49 in 1987 to 2.60 in 1992 (p < 0.001). Aviators who were 40-44 years old were at the greatest risk, with an annual rate of 1.6 cases per 1,000 aviator-years. Among 132 aviators, 25.8% had cervical HNPs, 74.2% had lumbar HNPs, and none had thoracic HNPs. Operative management was required in 66.6% of cases. Those with cervical HNPs were not at increased risk for operative management compared to those with lumbar HNPs (RR = 0.961, Cl-0.95 = 0.723,1.28). About 7.4% of the aviators with HNP were permanently removed from Army flying duties due to HNP complications. RP Mason, KT (reprint author), USA,AEROMED RES LAB,AIRCREW PROTECT DIV,FT RUCKER,AL 36362, USA. NR 8 TC 13 Z9 13 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1996 VL 67 IS 4 BP 338 EP 340 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA UB528 UT WOS:A1996UB52800007 PM 8900985 ER PT J AU Kark, JA Burr, PQ Wenger, CB Gastaldo, E Gardner, JW AF Kark, JA Burr, PQ Wenger, CB Gastaldo, E Gardner, JW TI Exertional heat illness in Marine Corps recruit training SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID STROKE AB Background: Exertional heat illness (EHI) is a recurring problem in military training resulting in loss of manpower and training effectiveness. A scientific approach to this problem requires quantitative analysis of factors related to its occurrence. Methods: Review of clinic and hospital records identified all cases of EHI occurring among 217,000 Marine Corps recruits (90% male, 80% age 18-20 yr) entering 12-week basic training at Parris Island, SC during 1982-1991. Results: There were 1454 cases, 89% males and 11% females; 11% of male and no female cases were hospitalized. The majority (88%) of cases occurred during May-September, with a peak rate of 2% of recruits in summer. Most of the cases occurred during the cooler early morning hours when recruits performed strenuous exercise. During 0700-0900 hours the rate of heat casualties increased substantially as the Wet Bulb Globe Temperature Index (WBGT) increased, beginning at levels as low as 65 degrees F. EHI rates increased 26- and 39-fold at WBGT 75-<80 degrees F (over baseline rates at <65 degrees F) for immediate and prior day exposures, respectively. Exposure to WBGT of 80+degrees F was infrequent (25%) among the early morning cases at the time of illness, while it was common (87%) on the day prior to illness, suggesting a lasting effect of heat exposure. Conclusions: Risk for EHI in military training increases markedly as WBGT levels rise above 65 degrees F; cases occur primarily with strenuous exercise (e.g., running); and heat stress exposure on prior days may be important. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. HOWARD UNIV HOSP,WASHINGTON,DC. USA,ENVIRONM MED RES INST,NATICK,MA 01760. USN HOSP,BEAUFORT,SC. NR 33 TC 59 Z9 65 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1996 VL 67 IS 4 BP 354 EP 360 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA UB528 UT WOS:A1996UB52800011 PM 8900989 ER PT J AU Potegal, M Hebert, M DeCoster, M Meyerhoff, JL AF Potegal, M Hebert, M DeCoster, M Meyerhoff, JL TI Brief, high-frequency stimulation of the corticomedial amygdala induces a delayed and prolonged increase of aggressiveness in male syrian golden hamsters SO BEHAVIORAL NEUROSCIENCE LA English DT Article; Proceedings Paper CT 22nd Annual Meeting of the Society-for-Neuroscience CY OCT 25-30, 1992 CL ANAHEIM, CA SP Soc Neurosci ID LONG-TERM POTENTIATION; MEDIAL-AMYGDALA; NERVOUS-SYSTEM; BITING ATTACK; TIME COURSE; MALE-RATS; BEHAVIOR; RECEPTOR; INDUCTION; CONNECTIONS AB Brief 200-Hz stimulation of the corticomedial amygdala (CMA) increases the aggressiveness of male Syrian golden hamsters for about 30 min; the effect peaks 10-15 min after stimulation. This effect is sensitive to stimulation amplitude and frequency. Stimulation at the parameters that reduce attack latency increases flank marking but does not affect copulation latency or general activity. Immunocytochemical analysis suggests that stimulation effects may be coupled to c-fos expression and that unilateral stimulation has bilateral effects. CMA stimulation effects appear to mimic part of the time course of behaviorally induced attack priming. The temporal persistence of aggression may result from long-term potentiation-like changes within CMA-related neural circuitry. C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC. NR 77 TC 27 Z9 27 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7044 J9 BEHAV NEUROSCI JI Behav. Neurosci. PD APR PY 1996 VL 110 IS 2 BP 401 EP 412 DI 10.1037/0735-7044.110.2.401 PG 12 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA UF919 UT WOS:A1996UF91900019 PM 8731066 ER PT J AU Mahadik, SP Scheffer, RE Mukherjee, S Correnti, EE AF Mahadik, SP Scheffer, RE Mukherjee, S Correnti, EE TI Altered signal transduction in fibroblasts from first-episode schizophrenic patients SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. VET AFFAIRS MED CTR,AUGUSTA,GA. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD APR 1 PY 1996 VL 39 IS 7 BP 67 EP 67 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA UE893 UT WOS:A1996UE89300063 ER PT J AU Scheffer, RE Correnti, EE Mukherjee, S AF Scheffer, RE Correnti, EE Mukherjee, S TI Parkinsonism in drug-naive first-episode schizophrenic patients SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD APR 1 PY 1996 VL 39 IS 7 BP 73 EP 73 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA UE893 UT WOS:A1996UE89300069 ER PT J AU Mahadik, SP Shendarkar, NS Scheffer, RE Mukherjee, S Correnti, EE AF Mahadik, SP Shendarkar, NS Scheffer, RE Mukherjee, S Correnti, EE TI Defective utilization of precursor essential. Fatty acids in schizophrenia SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. VET AFFAIRS MED CTR,AUGUSTA,GA. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD APR 1 PY 1996 VL 39 IS 7 BP 301 EP 301 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA UE893 UT WOS:A1996UE89300293 ER PT J AU Ferrick, MG Yankielun, NE Nelson, DF AF Ferrick, MG Yankielun, NE Nelson, DF TI A Doppler radar for continuous remote measurement of river ice velocity SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE Doppler radar; river ice velocity; velocity measurement; error analysis; river breakup; frazil run ID MOTION AB River ice velocity measurements are fundamental to analyses of river ice dynamics. Ice velocity measurement with a continuous-wave Doppler radar system having real-time data acquisition and digital signal processing capability was evaluated during a river breakup and a frazil run on the Connecticut River. This system can be rapidly deployed, requires minimal operator interaction, will continuously acquire, process, store, and display ice velocity data, and does not depend on visibility conditions. In parallel, video records of ice motion were obtained at the same location for later manual processing and comparison with the radar results. We describe the Doppler radar system and obtain bounding estimates of possible measurement errors. The principal error in Doppler ice velocity measurement is due to the beam width of the radar antenna, and an analytical method is developed to minimize this error. Measured ice velocities ranged from 1 to 2.5 m/s during the river breakup, and from 0.5 to 0.65 m/s in the frazil run. Quantitative comparisons between the radar and video results show fundamental agreement between these measurement methods, and demonstrate that Doppler radar is an effective, efficient, and precise tool for obtaining river ice velocities over the full range of possible ice and velocity conditions. RP Ferrick, MG (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD APR PY 1996 VL 23 IS 2 BP 408 EP 417 PG 10 WC Engineering, Civil SC Engineering GA UJ460 UT WOS:A1996UJ46000009 ER PT J AU Cardello, AV AF Cardello, AV TI The human senses and food behavior .1. Vision SO CEREAL FOODS WORLD LA English DT Article ID COLOR; IDENTIFICATION; SWEETNESS; BEVERAGES; FLAVOR; AROMA RP Cardello, AV (reprint author), USA,RES DEV & ENGN CTR,NATICK,MA, USA. NR 10 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD APR PY 1996 VL 41 IS 4 BP 222 EP & PG 3 WC Food Science & Technology SC Food Science & Technology GA UJ728 UT WOS:A1996UJ72800007 ER PT J AU Loube, DI Poceta, JS Morales, MC Peacock, MD Mitler, MM AF Loube, DI Poceta, JS Morales, MC Peacock, MD Mitler, MM TI Self-reported snoring in pregnancy - Association with fetal outcome SO CHEST LA English DT Article DE fetal outcome; obstructive sleep apnea; pregnancy; snoring; women ID OBSTRUCTIVE SLEEP-APNEA; WOMEN AB Objectives: To determine the incidence of self-reported snoring in pregnant compared with nonpregnant women. To compare indicators of fetal outcome in pregnant women with self-reported frequent snoring vs those without snoring. Study design: Prospective, nonrandomized screening and comparison between groups. Patients: Three hundred fifty pregnant women and 110 age-matched nonpregnant women. Methods: Survey evaluating self-reported snoring. For the pregnant women, infant birthweight, APGAR scores, and other indicators of fetal outcome were obtained by record review. Results: Frequent snoring was reported in 14% of the pregnant women vs 4% of the nonpregnant women (chi(2)=6.2; df=1; p<0.05). The pregnant women who reported frequent snoring did not have deliveries resulting in infants with evidence of an increase in compromised outcomes. Conclusions: Frequent snoring is reported more often in pregnant than in nonpregnant women. Snoring mothers do not appear to be at increased risk for delivering infants with fetal compromise as might be expected with the concomitant occurrence of obstructive sleep apnea. C1 SCRIPPS CLIN & RES FDN,DIV SLEEP DISORDERS,LA JOLLA,CA 92037. BROOKE ARMY MED CTR,PULM & OBSTET SERV,FT SAM HOUSTON,TX 78234. RP Loube, DI (reprint author), WALTER REED ARMY MED CTR,PULM SERV,WASHINGTON,DC 20307, USA. NR 34 TC 104 Z9 109 U1 0 U2 7 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1996 VL 109 IS 4 BP 885 EP 889 DI 10.1378/chest.109.4.885 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UE724 UT WOS:A1996UE72400011 PM 8635365 ER PT J AU Sfikakis, PP Souliotis, VL Katsilambros, N Markakis, K Vaiopoulos, G Tsokos, GC Panayiotidis, P AF Sfikakis, PP Souliotis, VL Katsilambros, N Markakis, K Vaiopoulos, G Tsokos, GC Panayiotidis, P TI Downregulation of interleukin-2 and alpha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID RHEUMATOID-ARTHRITIS; FUNCTION-INVITRO; CYTO-TOXICITY; CIS-PLATINUM; CIS-DICHLORODIAMMINEPLATINUM(II); COMPLEXES; CELLS; ENHANCEMENT; INVIVO; PLASMA AB To further investigate the mechanisms by which the antineoplastic agent cisplatin interferes with immune function, we studied its effect on the biosynthesis of interleukin-2 (IL-2) and its alpha-chain receptor (IL-2R alpha). Normal human peripheral blood lymphocytes (PBL) were activated in vitro with phytohemagglutinin (PHA), and anti-CD3 antibody in the presence of various concentrations of cisplatin. Purified T cells were also cultured with anti-CD3 antibody and costimulated by CD80 (B7-1, B7/BB1)-transfected P815 mastocytoma cells in the presence of cisplatin. Tritiated thymidine incorporation assays, an enzyme-linked immunosorbent assay for soluble IL-2R(alpha determination, and RNA dot-blot analysis and hybridization with IL-2- and IL-2R alpha-specific probes were used. PHA-induced and anti-CD3 antibody-induced proliferation of PBL were significantly inhibited by cisplatin at concentrations attainable in vivo. This inhibition was not due to direct cell death as shown by the absence of trypan blue uptake in the presence of high concentrations of cisplatin. Therapeutic concentrations of cisplatin (1 mu g/ml) also inhibited the IL-2-dependent proliferation of purified T cells, mediated via the CD28-CD80 costimulatory pathway. In addition, the amount of soluble IL-2R alpha released in the T cell culture supernatants was decreased by cisplatin in a dose-dependent fashion, suggesting that inhibition of cell proliferation was associated with a parallel decrease in IL-2R alpha production. These effects correlated with a specific cisplatin-induced downregulation of both IL-2 and IL-2R alpha messenger RNA accumulation in PHA-stimulated PBL that was dependent on the concentration of the drug. These findings suggest that the immunomodullatory effects of cisplatin may result in part from its capacity to directly downregulate the IL-2/IL-2R system in activated lymphocytes. (C) 1996 Academic Press, Inc. C1 NATL HELLEN RES FDN,LAB CHEM CARCINOGENESIS,ATHENS,GREECE. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. RP Sfikakis, PP (reprint author), UNIV ATHENS,SCH MED,RES IMMUNOL LAB,DEPT PROPEDEUT MED 1,GR-11527 ATHENS,GREECE. NR 33 TC 15 Z9 16 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD APR PY 1996 VL 79 IS 1 BP 43 EP 49 DI 10.1006/clin.1996.0049 PG 7 WC Immunology; Pathology SC Immunology; Pathology GA UJ249 UT WOS:A1996UJ24900006 PM 8612350 ER PT J AU Bass, JW Longfield, JN Jones, RG Hartmann, RM AF Bass, JW Longfield, JN Jones, RG Hartmann, RM TI Serum levels of penicillin in basic trainees in the US army who received intramuscular penicillin G benzathine SO CLINICAL INFECTIOUS DISEASES LA English DT Article C1 USA,MED DEPT ACT,PREVENT MED SERV,FT SILL,OK. USA,CLIN OPERAT DIRECTORATE,MED COMMAND,FT SAM HOUSTON,TX. RP Bass, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 4 TC 12 Z9 12 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1996 VL 22 IS 4 BP 727 EP 728 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UB853 UT WOS:A1996UB85300030 PM 8729225 ER PT J AU Gayle, EL Shanley, DJ Simon, CA Myers, JB Delaplain, CB AF Gayle, EL Shanley, DJ Simon, CA Myers, JB Delaplain, CB TI Aggressive granulomatosis causing a painful hip arthroplasty - Findings on bone and Ga-67 imaging SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID CEMENTLESS C1 TRIPLER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,HONOLULU,HI 96859. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 1996 VL 21 IS 4 BP 337 EP 339 DI 10.1097/00003072-199604000-00025 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA UE444 UT WOS:A1996UE44400025 PM 8925629 ER PT J AU Conger, LA Grabski, WJ AF Conger, LA Grabski, WJ TI Dilantin(R) hypersensitivity reaction SO CUTIS LA English DT Article ID PHENYTOIN HYPERSENSITIVITY; DIPHENYLHYDANTOIN; INVITRO; HEPATITIS; HEPATOTOXICITY; THERAPY AB Dilantin(R) hypersensitivity syndrome is characterized by fever, rash, lymphadenopathy, facial edema, and hepatitis, Anemia, pharyngitis, diarrhea, and nephritis may also be present. The eruption may present as the classic erythematous follicular papules and pustules; or it may be pleomorphic, presenting as a morbilliform eruption, erythroderma, or toxic epidermal necrolysis, Early recognition and discontinuation of the medication are necessary to prevent a potentially fatal outcome, A case is presented and the literature reviewed. RP Conger, LA (reprint author), USA,SAN ANTONIO,TX, USA. NR 32 TC 17 Z9 19 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD APR PY 1996 VL 57 IS 4 BP 223 EP 226 PG 4 WC Dermatology SC Dermatology GA UF606 UT WOS:A1996UF60600006 PM 8727770 ER PT J AU McCarthy, MJ Davidson, JM Cardone, JS Anderson, LL AF McCarthy, MJ Davidson, JM Cardone, JS Anderson, LL TI Cutis laxa acquisita associated with multiple myeloma: A case report and review of the literature SO CUTIS LA English DT Review ID GENERALIZED ELASTOLYSIS; ELASTIN AB Cutis laxa acquisita is a rare disorder that affects collagen and elastin metabolism, The cause is unknown. Characteristic features include sagging and laxity of the skin, as well as involvement of the lungs, heart, gastrointestinal system, and urogenital tract. Three cases of cutis laxa acquisita have been reported in association with multiple myeloma, Due to the rarity of these disorders, a linkage has been postulated, The clinical and histologic data from the fourth case of cutis laxa acquisita associated with multiple myeloma were compared to the three other cases previously reported in the literature, The relationship between acquired cutis laxa and multiple myeloma is unclear, with only one case revealing possible immune-mediated elastin destruction via IgG immunoglobulin bound to dermal elastin fibers on immunofluoresence examination, No pattern in the clinical courses of the disorder can be seen on review of the four cases with coincident disease, We hypothesize that cutis laxa acquisita represents a paraneoplastic process of multiple myeloma, given the rarity of these diseases, Further investigation is necessary to determine the underlying linkage between these disorders, We suggest that serum and urine protein electrophoresis results be obtained in patients presenting with cutis laxa acquisita to screen for multiple myeloma given this association. C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. WOMACK ARMY MED CTR,HEMATOL ONCOL SERV,FT BAGG,NC. VANDERBILT UNIV,MED CTR,DEPT PATHOL,NASHVILLE,TN 37232. DEPT VET AFFAIRS MED CTR,MED RES SERV,NASHVILLE,TN 37212. DARNALL ARMY HOSP,DERMATOL SERV,FT HOOD,TX. FU NIA NIH HHS [AG 06528] NR 30 TC 16 Z9 16 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD APR PY 1996 VL 57 IS 4 BP 267 EP 270 PG 4 WC Dermatology SC Dermatology GA UF606 UT WOS:A1996UF60600018 PM 8727781 ER PT J AU Lisehora, GB Peters, CC Lee, YTM Barcia, PJ AF Lisehora, GB Peters, CC Lee, YTM Barcia, PJ TI Tuberculous peritonitis - Do not miss it SO DISEASES OF THE COLON & RECTUM LA English DT Article; Proceedings Paper CT 94th Annual Meeting of the American-Society-of-Colon-and-Rectal-Surgeons CY MAY 07-12, 1995 CL MONTREAL, CANADA SP Amer Soc Colon & Rectal Surgeons DE tuberculous (TB); peritonitis; mycobacterial; granulomatous; laparotomy; laparoscopy; computed tomographic scan ID ABDOMINAL TUBERCULOSIS; DIAGNOSIS AB Incidence of tuberculosis is sharply rising in the United States, and tuberculous peritonitis is often diagnosed late in the course of the disease, resulting in undue patient morbidity and mortality. PURPOSE: Purpose of this study was to better identify which clinical, laboratory, radiologic, and invasive procedures were most useful in diagnosing tuberculous peritonitis. METHODS: All cases of tuberculous peritonitis diagnosed between 1982 and 1994 were reviewed retrospectively to discern which laboratory, radiographic, and procedural tests were helpful in diagnosing the condition. RESULTS: Twenty-eight cases of tuberculous peritonitis were diagnosed during the studied period. Two patients were not diagnosed until autopsy. Patients from all socioeconomic classes and multiple races ranged in age from 3 to 69 (mean, 29.5) years. Most patients presented with a chronic wasting illness, mild abdominal pain, and fever. Purified protein derivative was only positive in 5 of 16 patients. Chest radiographs were suggestive of pulmonary tuberculosis (TB) in five patients. Ultrasound examination of the abdomen was helpful in five patients, and computed tomographic scan was suspicious in 16 of 17 patients. Sputum for acid fast bacillus (AFB) smear was positive in 3 of 14 patients, and paracentesis for AFB smear was positive in 1 of 8 patients. Routine blood work was not helpful. Laparoscopy was diagnostic in five of seven patients. Laparotomy and tissue biopsy of characteristic tissue for AFB smear and culture was diagnostic in 20 of 20 patients. Once diagnosed, all patients responded rapidly to empiric antituberculous medical therapy, except one patient with miliary TB who died shortly after diagnosis. A trend in earlier diagnosis was noted in recent years and is felt to be the result of an elevated index of suspicion. CONCLUSIONS: TB peritonitis may be fatal but is medically cured if diagnosed in a timely fashion. It is essential that the clinician suspect the disease in appropriate patients. Tests frequently associated with TB such as chest radiograph and purified protein derivative are not sensitive in detection of TB peritonitis. Computed tomographic scan is the most useful radiographic study. Mini laparotomy with tissue biopsy for smear and culture is the most sensitive and specific diagnostic procedure. RP Lisehora, GB (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859, USA. NR 17 TC 34 Z9 34 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0012-3706 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD APR PY 1996 VL 39 IS 4 BP 394 EP 399 DI 10.1007/BF02054053 PG 6 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA UE834 UT WOS:A1996UE83400008 PM 8878498 ER PT J AU Bridges, TS Wright, RB Gray, BR Gibson, AB Dillon, TM AF Bridges, TS Wright, RB Gray, BR Gibson, AB Dillon, TM TI Chronic toxicity of Great Lakes sediments to Daphnia magna: Elutriate effects on survival, reproduction and population growth SO ECOTOXICOLOGY LA English DT Article DE Daphnia magna; chronic toxicity; sediment elutriates; population modelling ID CONTAMINATED SEDIMENT; LIFE TABLE; DYNAMICS; ZOOPLANKTON; CADMIUM; WATER; TESTS; CRUSTACEA; BIOASSAYS; TURBIDITY AB Seventeen Great Lakes sediments ranging in degree of expected toxicity were evaluated using a 21 day sediment elutriate bioassay with Daphnia magna. Sediments differed in their effects on survival, age at first reproduction, the number of broods produced and the total number of young produced per adult. Sediments producing low survivorship (50-60%) also had negative effects on reproduction. However, both positive and negative effects on reproduction were found among sediments producing high survivorship. To integrate all test end-points, a stochastic matrix population model was constructed and parameterized with survival and reproduction data from each sediment. By including estimates of variability in vital rates, the model output provided quantitative estimates of uncertainty in projected population size. Sediment effects on survival and reproduction translated into large differences in projected population growth; mean estimates of projected population size at day 28 of the simulations ranged over two orders of magnitude among the 17 sediments. Reproductive timing (e.g. age at first reproduction), followed by fecundity and survivorship, had the largest effect on population growth. Results of this study also indicate that the presence of suspended sediment in elutriates may confound toxicity evaluations using cladocerans. The concentration of total suspended solids was negatively correlated with age at first reproduction and positively correlated with measures of fecundity and population growth. In order to realize the potential benefits of chronic testing we must develop ecologically relevant ways of interpreting sediment bioassay results and expressing the uncertainty associated with our estimates of ecological risk. C1 ASCI CORP, VICKSBURG, MS USA. RP Bridges, TS (reprint author), USA, CORPS ENGINEERS, WATERWAYS EXPT STN, 3909 HALLS FERRY RD, VICKSBURG, MS 39180 USA. OI Gray, Brian/0000-0001-7682-9550 NR 66 TC 20 Z9 21 U1 1 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 EI 1573-3017 J9 ECOTOXICOLOGY JI Ecotoxicology PD APR PY 1996 VL 5 IS 2 BP 83 EP 102 DI 10.1007/BF00119048 PG 20 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA UH480 UT WOS:A1996UH48000002 PM 24193573 ER PT J AU Letterie, GS Salminen, ER McClure, GB AF Letterie, GS Salminen, ER McClure, GB TI An electronic bulletin board for instruction in reproductive endocrinology in a residency in obstetrics and gynecology SO FERTILITY AND STERILITY LA English DT Article DE electronic bulletin board; resident education; reproductive endocrinology AB Objective: To explore the role of an electronic bulletin board as a means of computer-based learning in reproductive endocrinology for residents in obstetrics and gynecology. Design: An electronic bulletin board was networked to all residents to present a formal lecture series in reproductive endocrinology and an informal question, answer, and discussion session after each lecture. Ten lectures were presented, one each month, throughout the academic year followed by question, answer, and discussion sessions. All lectures could be stored in an electronic file folder or printed as hard copy for review. A questionnaire was distributed at the conclusion of the project to assess previous resident experience with computers, resident response to, and utilization of the bulletin board. Setting: A residency program in obstetrics and gynecology in a major medical center. Participants: Twenty-four residents in a 4-year program. Main Outcome Measures: Previous computer experience, ease of use, resident participation, and satisfaction with the bulletin board. Results: Sixty-five percent of the residents considered themselves computer literate and 33% previously had taken a course in computer technology. Computer experience in word processing, spreadsheet, and database management was related by 55%, 40%, and 25% of the residents, respectively. Ninety-five percent of the residents accessed the bulletin board for the lectures and found this system a convenient means of review. Sixty percent reviewed the lectures and stored them in an electronic file folder for later review. Forty percent printed the lecture on hard copy. On a scale of 1 to 5 (1 = lowest; 5 = highest), overall resident satisfaction was high at 4.5. Conclusion: Our data suggest a potential role for electronic bulletin boards as a complement to standard teaching protocols in resident education. The relative ease of use and satisfaction suggest that these techniques are feasible and offer an effective method of on-line instruction. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. RP Letterie, GS (reprint author), UNIV WASHINGTON,VIRGINIA MASON MED CTR,REPROD ENDOCRINOL SERV,DEPT OBSTET & GYNECOL,SEATTLE,WA 98110, USA. NR 6 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 1996 VL 65 IS 4 BP 883 EP 885 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA UB328 UT WOS:A1996UB32800038 PM 8654659 ER PT J AU Amponsah, A Berggren, R Xu, Y Le, M Brown, W Wolf, M Boedeker, E Fang, F AF Amponsah, A Berggren, R Xu, Y Le, M Brown, W Wolf, M Boedeker, E Fang, F TI Construction of a recombinant Salmonella-based enteropathogenic Escherichia coli vaccine SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 UNIV COLORADO, HLTH SCI CTR, DEPT MED, DENVER, CO 80262 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. UNIV MARYLAND, SCH MED, DEPT MED, BALTIMORE, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A853 EP A853 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73703396 ER PT J AU Bloom, P Blake, D Russell, R Noriega, F Wolf, M Boedeker, E AF Bloom, P Blake, D Russell, R Noriega, F Wolf, M Boedeker, E TI Safety, immunogenicity, and efficacy of an attenuated shigella vaccine expressing the pilus antigen (AF/R1) of a rabbit enteropathogenic E-coli (RDEC-1). SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 UNIV MARYLAND, DIV GASTROENTEROL, COLLEGE PK, MD 20742 USA. UNIV MARYLAND, CTR VACCINE DEV, COLLEGE PK, MD 20742 USA. VAMC, RES SERV, BALTIMORE, MD USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A867 EP A867 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73703452 ER PT J AU DAddio, VJ Sayles, J Alvarez, C Lally, K Bass, BL AF DAddio, VJ Sayles, J Alvarez, C Lally, K Bass, BL TI Bile augments rabbit esophageal mucosal growth in vitro. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 VET ADM MED CTR, DEPT SURG, BALTIMORE, MD USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A87 EP A87 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73700343 ER PT J AU Farrington, CA Shaffer, RT Kadakia, SC AF Farrington, CA Shaffer, RT Kadakia, SC TI Gastric acid secretion in aids patients. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT MED, GASTROENTEROL SERV, SAN ANTONIO, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A906 EP A906 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73703607 ER PT J AU Fedalei, AG Parker, AL Kadakia, SC Enghardt, MH AF Fedalei, AG Parker, AL Kadakia, SC Enghardt, MH TI Evaluation of the string test (Enterotest(R)) for diagnosing Helicobacter pylori infection. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT MED, GASTROENTEROL SERV, SAN ANTONIO, TX USA. BROOKE ARMY MED CTR, DEPT PATHOL, SAN ANTONIO, TX USA. NR 0 TC 4 Z9 4 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A16 EP A16 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73700060 ER PT J AU Kadakia, SC Katz, N Gower, WR AF Kadakia, SC Katz, N Gower, WR TI Effect of intravenous erythromycin on gastric emptying in patients with anorexia nervosa and bulimia. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT MED, GASTROENTEROL & MUCL MED SERV, SAN ANTONIO, TX USA. BROOKE ARMY MED CTR, DEPT RADIOL, GASTROENTEROL & MUCL MED SERV, SAN ANTONIO, TX USA. UNIV S FLORIDA, VA HOSP, COLL MED, DEPT BIOCHEM & MOLEC BIOL, TAMPA, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A689 EP A689 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73702740 ER PT J AU Loughney, TM Lazas, DJ Frishberg, DP Emory, TS Maydonovitch, CL Wong, RKH AF Loughney, TM Lazas, DJ Frishberg, DP Emory, TS Maydonovitch, CL Wong, RKH TI Short segment Barrett's esophagus: Serial endoscopic and histologic assessment SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A181 EP A181 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73700717 ER PT J AU Loughney, TM Lazas, DJ Maydonovitch, C Wong, RKH AF Loughney, TM Lazas, DJ Maydonovitch, C Wong, RKH TI Short and long segment Barrett's esophagus: 24 hour pH monitoring and esophageal manometry SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A180 EP A180 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73700716 ER PT J AU McBride, CE Smith, MA Lui, J Maydonovitch, CL Wong, RKH AF McBride, CE Smith, MA Lui, J Maydonovitch, CL Wong, RKH TI Characteristics of upright gastroesophageal reflux disease (GERD): Esophageal 24 hour pH, manometric, endoscopic, and clinical features. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A190 EP A190 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73700754 ER PT J AU McQueen, C Lowell, G Fleming, E Biediger, W Tseng, LY Wolf, M Cassels, F Le, M Brown, W AF McQueen, C Lowell, G Fleming, E Biediger, W Tseng, LY Wolf, M Cassels, F Le, M Brown, W TI Protection after immunization with proteosomes containing adherence pili from a rabbit E-coli diarrheal strain (RDEC-1). SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. INTELLIVAX INC, BALTIMORE, MD USA. VET ADM MED CTR, DENVER, CO 80220 USA. UNIV COLORADO, MED CTR, DENVER, CO 80202 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A965 EP A965 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73703840 ER PT J AU Shaffer, RT Francis, J Carrougher, J Kadakia, SC AF Shaffer, RT Francis, J Carrougher, J Kadakia, SC TI Effect of omeprazole on Barrett's epithelium after 3 years of therapy. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT MED, GASTROENTEROL SERV, SAN ANTONIO, TX USA. NR 0 TC 12 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A255 EP A255 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73701014 ER PT J AU Shay, S Richter, J AF Shay, S Richter, J TI Additional reflux events (RE) during acid clearing characterize long vs short pHRE's. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC USA. CLEVELAND CLIN, CLEVELAND, OH 44106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A256 EP A256 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73701018 ER PT J AU Sjogren, MH Squire, O Goudarzi, B Kapur, J Billups, L Patel, A Rosen, D Salata, K AF Sjogren, MH Squire, O Goudarzi, B Kapur, J Billups, L Patel, A Rosen, D Salata, K TI Hepatitis C infection among women. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A1330 EP A1330 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73705298 ER PT J AU Tai, YH McQueen, CE Pryce, K Shih, K AF Tai, YH McQueen, CE Pryce, K Shih, K TI Tannic acid inhibits cyclic AMP- and calcium-induced intestinal secretion. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT GASTROENTEROL, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1996 VL 110 IS 4 SU S BP A365 EP A365 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UF737 UT WOS:A1996UF73701453 ER PT J AU Kadakia, SC Angueira, CE Ward, JA Moore, M AF Kadakia, SC Angueira, CE Ward, JA Moore, M TI Gastrointestinal endoscopy in patients taking antiplatelet agents and anticoagulants: Survey of ASGE members. SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT MED,HOSP ADM SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT CLIN INVEST,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1996 VL 43 IS 4 BP 96 EP 96 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UH281 UT WOS:A1996UH28100096 ER PT J AU Parker, A Kadakia, SC Howell, G Pesetski, J AF Parker, A Kadakia, SC Howell, G Pesetski, J TI Reuse of single use supplies - The pendulum swings. SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT NURSING,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1996 VL 43 IS 4 BP 115 EP 115 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UH281 UT WOS:A1996UH28100115 ER PT J AU Tanner, PE Kadakia, SC Farrington, CA AF Tanner, PE Kadakia, SC Farrington, CA TI Colonic lavage bowel preparation - Does cisapride help? SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1996 VL 43 IS 4 BP 124 EP 124 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UH281 UT WOS:A1996UH28100124 ER PT J AU Lawitz, E Kadakia, SC AF Lawitz, E Kadakia, SC TI Utility of the preoperative fiberoptic flexible sigmoidoscopy (FFS) in the evaluation of patients with suspected gynecologic malignancy. SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1996 VL 43 IS 4 BP 308 EP 308 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UH281 UT WOS:A1996UH28100308 ER PT J AU Bruce, DA Greene, B Schaffer, A AF Bruce, DA Greene, B Schaffer, A TI Unique cofferdam construction: Pt Marion Lock and Dam, Pennsylvania SO GROUND ENGINEERING LA English DT Article C1 USA,CORPS ENGINEERS,PITTSBURGH,PA 15222. RP Bruce, DA (reprint author), NICHOLSON CONSTRUCT CO,POB 98,BRIDGEVILLE,PA 15017, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU EMAP BUSINESS PUBLISHING LTD PI LONDON PA 151 ROSEBERY AVE, LONDON, ENGLAND EC1R 4QX SN 0017-4653 J9 GROUND ENG JI Ground Eng. PD APR PY 1996 VL 29 IS 3 BP 41 EP 44 PG 4 WC Engineering, Civil SC Engineering GA UH539 UT WOS:A1996UH53900010 ER PT J AU Kronenberg, S Brucker, GJ Bechtel, E Gentner, F AF Kronenberg, S Brucker, GJ Bechtel, E Gentner, F TI Directional detector of gamma ray sources SO HEALTH PHYSICS LA English DT Article DE ionization chambers; gamma radiation; x rays; contamination ID X-RAY AB This work describes the design, development, and characterization of an ionization chamber to detect and locate gamma ray sources with intensities down to 100 mu Gy h(-1). The results show that sources of x ray and gamma radiation in the energy range of 14 to 1,250 keV can be located. The directional sensitivity of this type of monitor is dependent on several parameters, such as photon energy, intensity, and the degree of complexity in terms of the number and type of sources in a contaminated area, An application important to the Army is to identify hotspots in a contaminated area and thereby indicate to personnel safer paths around them, Another possible use for this type of monitor may be in security applications in the prevention of shipping or storing clandestine sources. RP Kronenberg, S (reprint author), USA, AMCPM NNN F, NBC DEF SYST RADIAC PROJECT OFF, FT MONMOUTH, NJ 07703 USA. NR 13 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD APR PY 1996 VL 70 IS 4 BP 505 EP 511 DI 10.1097/00004032-199604000-00007 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA UA703 UT WOS:A1996UA70300007 PM 8617590 ER PT J AU ShukittHale, B Kadar, T Marlowe, BE Stillman, MJ Galli, RL Levy, A Devine, JA Lieberman, HR AF ShukittHale, B Kadar, T Marlowe, BE Stillman, MJ Galli, RL Levy, A Devine, JA Lieberman, HR TI Morphological alterations in the hippocampus following hypobaric hypoxia SO HUMAN & EXPERIMENTAL TOXICOLOGY LA English DT Article DE hypobaric hypoxia; chronic altitude exposure; hippocampus; delayed neurotoxicity; ischemia ID CENTRAL-NERVOUS-SYSTEM; RAT HIPPOCAMPUS; ALTITUDE; ISCHEMIA; DYSFUNCTION; EXPOSURE; OXYGEN AB 1 The morphological consequences of hypobaric hypoxia, exposure to reduced pressure atmospheres, were examined in the hippocampus of male Fischer 344 rats. Severe chronic hypoxia can produce permanent neuronal damage with hippocampal structures being especially vulnerable. 2 Hippocampal morphology was studied using histological observations after a 4 day exposure to sea level, 5500 m, or 6400 m. Two groups tested at 6400 m were sacrificed at different intervals following exposure, 72 and 144 h, to examine the effect of post-exposure time on neuronal damage. 3 Histological damage was observed in rats' brains following exposure to altitude, with cell degeneration and death increasing as altitude increased. In addition, it was found that the longer the time following exposure before sacrifice, the more noticeable the damage, suggesting delayed neurotoxicity. Increases in the number of damaged cells following altitude were significant for the CA3 region of one 6400 m group; however, other differences did not reach statistical significance. Rats exposed to altitude for 4 days ate less and lost significantly more weight than did animals at sea level. 4 It appears that 4 days of exposure to altitudes less than or equal to 6400 m does produce changes in the CA3 subfield, but the damage is different than that seen with other models of non-transient ischemia. C1 USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV,NATICK,MA 01760. GEOCENTERS INC,NEWTON,MA 02159. ISRAEL INST BIOL RES,DEPT PHARMACOL,IL-70450 NESS ZIONA,ISRAEL. NR 30 TC 31 Z9 36 U1 1 U2 3 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0144-5952 J9 HUM EXP TOXICOL JI Hum. Exp. Toxicol. PD APR PY 1996 VL 15 IS 4 BP 312 EP 319 PG 8 WC Toxicology SC Toxicology GA UF147 UT WOS:A1996UF14700007 PM 8845221 ER PT J AU Holt, KG Obusek, JP Fonseca, ST AF Holt, KG Obusek, JP Fonseca, ST TI Constraints on disordered locomotion. A dynamical systems perspective on spastic cerebral palsy SO HUMAN MOVEMENT SCIENCE LA English DT Article DE cerebral palsy; locomotion; oscillatory models ID MUSCLE HYPOEXTENSIBILITY; INDEPENDENT WALKING; ENERGY-EXPENDITURE; MOTOR CONTROL; CHILDREN; GAIT; MECHANISMS; STIFFNESS; PATTERNS; MODEL AB Upper motor neuron disorders (UMN) result in abnormal movement patterns that are due to spasticity, weakness, cocontraction of muscles, inappropriate timing of muscle activations in relation to maximal mechanical advantage, and changes in the mechanical properties of muscles and connective tissues, Since many of the patterns observed in gait are reminiscent of immature patterns in non-disabled toddlers, prolonged abnormal patterns are often viewed as a failure of normal neural maturation. Since the 1960's the emphasis of therapeutic interventions has been to 'normalize' the movement pattern through a variety of neurotherapeutic techniques. The efforts have met with limited success. Recently there have been a number of publications that have emphasized the possibility that the observed patterns may develop or be functional adaptations to a neural system that is not 'normal', and that the observed movement patterns in pathological populations may be normal and optimal for that system (Fetters, 1991; Holt, 1993; Latash and Anson, in press; Winter et al., 1990). Some authors have emphasized that alternative patterns develop and are facilitated by redundancy in the motor system (Latash and Anson, in press). Our emphasis has been to pursue the notion that pattern development and functional adaptations in locomotion are driven by the underlying dynamics of the task and the dynamic resources available to the individual. We use a model developed within the dynamical systems framework, the force-driven, pendulum-spring model of locomotion, to parse out the energy forms that are needed for continued oscillations, and relate the energy forms to the dynamics that are available to a disordered system, specifically, spastic cerebral palsy (CP). We then attempt to relate the available dynamics to the observed gait patterns. In this way. we seek to understand ordered and disordered gaits as alternative functional solutions to the dynamical requirements for continued cycling of a periodically forced oscillator. The implications of the theoretical model and experimental findings are discussed with respect to therapeutic intervention, and the dynamical systems approach. C1 UNIV CONNECTICUT,CTR ECOL STUDY PERCEPT & ACT,STORRS,CT. USA,ARMY MED SPECIALIST CORPS,NATICK,MA 01760. RP Holt, KG (reprint author), BOSTON UNIV,SARGENT COLL ALLIED HLTH PROFESS,DEPT PHYS THERAPY,APPL KINESIOL PROGRAM,BOSTON,MA 02215, USA. RI Fonseca, Sergio/C-5408-2013 OI Fonseca, Sergio/0000-0002-2979-8744 NR 74 TC 30 Z9 31 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9457 J9 HUM MOVEMENT SCI JI Hum. Mov. Sci. PD APR PY 1996 VL 15 IS 2 BP 177 EP 202 DI 10.1016/0167-9457(95)00043-7 PG 26 WC Neurosciences; Psychology; Psychology, Experimental; Sport Sciences SC Neurosciences & Neurology; Psychology; Sport Sciences GA VD452 UT WOS:A1996VD45200003 ER PT J AU Yamamoto, T Exheverria, P AF Yamamoto, T Exheverria, P TI Detection of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene sequences in enterotoxigenic E-coli strains pathogenic for humans SO INFECTION AND IMMUNITY LA English DT Article ID COLONIZATION FACTOR; PERSISTENT DIARRHEA; TOXIN; CHILDREN; ADHERENCE; PLASMIDS; ASSOCIATION; PATTERNS; COHORT; DNA AB The sequence of the enteroaggregative Escherichia coli enterotoxin 1 (EAST1) gene was present in most (or all) strains of human-colonizing enterotoxigenic E. coli (ETEC) with colonization factor antigen II (CFA/II) or CFA/IV (CS6). The EAST1 gene was also strongly associated with PCF09(+) ETEC or CFA/I+ ETEC elaborating heat-labile enterotoxin (and heat-stable enterotoxin I). In contrast, CFA/I+ ETEC elaborating heat-stable enterotoxin I, CFA/III+ ETEC, or CS17(+) ETEC exhibited very weak or no association. E. coli from healthy volunteers had no EAST1 gene sequence. A CFA/I+ ETEC strain (H10407) possessed multiple copies of the EAST1 gene on the CFA/I-encoding plasmid and chromosome. In one CFA/II+ ETEC strain, the EAST1 gene was present on the CFA/II-encoding plasmid. The EAST1 gene sequences of the CFA/I+ and CFA/II+ ETEC strains were identical to each other and 99.1% homologous to the reported gene sequence of enteroaggregative E. coli. The data indicate that the EAST1 gene is distributed among ETEC strains with a case of the presence of multiple copies in a single cell and that this distribution is associated with the adherence factor type. C1 ARMED FORCES RES INST MED SCI, DEPT BACTERIOL IMMUNOL & MOL GENET, BANGKOK 10400, THAILAND. RP Yamamoto, T (reprint author), INT MED CTR JAPAN, RES INST, DEPT INFECT DIS & TROP MED, SHINJUKU KU, 1-21-2 TOYAMA, TOKYO, JAPAN. NR 34 TC 112 Z9 113 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1996 VL 64 IS 4 BP 1441 EP 1445 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UC314 UT WOS:A1996UC31400053 PM 8606115 ER PT J AU Anderson, DR Yourick, JJ Moeller, RB Petrali, JP Young, GD Byers, SL AF Anderson, DR Yourick, JJ Moeller, RB Petrali, JP Young, GD Byers, SL TI Pathologic changes in rat lungs following acute sulfur mustard inhalation SO INHALATION TOXICOLOGY LA English DT Article ID HAIRLESS GUINEA-PIG AB Although the majority of deaths resulting from exposure to sulfur mustard (HD) have been due to pulmonary dysfunction, there are no detailed accounts of the pathogenesis or HD-induced lesions in the respiratory tract. Accordingly, we investigated the early changes within the trachea and lungs of rats following inhalation exposure to HD. Anesthetized rats were exposed by intratracheal intubation to vaporized HD (0.35 mg in 100 mu l absolute ethanol) or ethanol alone for 50 min. Animals were euthanatized at 0, 1, 4, 6, 12, 18, and 24 h postexposure (PE), and their respiratory tracts were prepared for histological and ultrastructural examination. In rats exposed to HD, multifocal, petechial hemorrhages were grossly evident on the pleural surface of the lung at 6 h PE. Atelectasis and edema of the accessory lobe occurred at 12-18 h PE. Histologically, lesions in the respiratory tract were confined primarily to the trachea, bronchi and larger bronchioles. In HD-exposed rats, there was a progressive depletion of the bronchiolar-associated lymphoid tissue (BALT), with necrosis of the lymphoid cells as early as 12 h PE. Necrosis and sloughing of the tracheal and bronchial epithelia at 6-12 h PE was followed by the formation of fibrinous pseudomembranes within the bronchi. Necrosis and separation of airway epithelia occurred at the mucosal/submucosal interface. Pseudomembranes formed almost exclusively in deepithelialized areas overlying the BALT. Cartilaginous lesions, characterized by necrosis of individual chondrocytes, were evident at 12 h PE. Pulmonary edema and occasional alveolar hemorrhage occurred from 18 to 24 h PE. Small bronchioles and alveoli were relatively unaffected and only a few inflammatory cells were observed at any time. C1 USA, MED RES INST CHEM DEF, COMPARAT PATHOL BRANCH, ABERDEEN PROVING GROUND, MD 21010 USA. RP Anderson, DR (reprint author), USA, MED RES INST CHEM DEF, APPL PHARMACOL BRANCH, ABERDEEN PROVING GROUND, MD 21010 USA. NR 14 TC 27 Z9 27 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD APR PY 1996 VL 8 IS 3 BP 285 EP 297 DI 10.3109/08958379609005436 PG 13 WC Toxicology SC Toxicology GA UJ171 UT WOS:A1996UJ17100006 ER PT J AU Tang, SS Moffatt, J AF Tang, SS Moffatt, J TI Development of an on-board fatigue processor for helicopters SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE fatigue; helicopter; flight loads; pattern recognition; load cycle spectrum AB An on-board fatigue processor was developed for helicopters. This processor can provide a continuous monitoring of fatigue usage of rotating mechanical components during flight using only standard flight control data as input. The monitoring methodology used in the fatigue processor reduces a complex load time-history into two parameters: load-cycle spectrum type and maximum load range. Correlations between the two parameters and the flight control data from various maneuvers are developed using flight load survey data. Pattern recognition method is used to identify (or correlate) the load-cycle spectrum type. Flight load models for the maximum load range are developed using multiple linear regression technique. Once the correlations are developed, only the flight control data are used by the fatigue processor to identify the load-cycle spectrum type, the corresponding component load range, and ultimately to compute the cumulative fatigue usage for the monitored components. Validation of the on-board fatigue processor was performed using flight load survey data and simulated flight conditions. The fatigue usages calculated by the fatigue processor compare well with the component fatigue usages computed directly from the measured component loads of the flight tests. Computation time for the fatigue usage calculation was done well below the processing time needed for real-time monitoring, on a small, personal computer platform. The method thus represents an efficient and practical monitoring approach for the on-board implementation in helicopters. C1 USA,AVIAT & TROOP COMMAND,FT EUSTIS,VA 23604. RP Tang, SS (reprint author), STRUCT INTEGR ASSOCIATES INC,3315 ALMADEN EXPRESSWAY,SUITE 24,SAN JOSE,CA 95118, USA. NR 12 TC 8 Z9 8 U1 2 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD APR PY 1996 VL 18 IS 3 BP 179 EP 189 DI 10.1016/0142-1123(95)00109-3 PG 11 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA UP466 UT WOS:A1996UP46600003 ER PT J AU Jensen, PS Watanabe, HK Richters, JE Roper, M Hibbs, ED Salzberg, AD Liu, S AF Jensen, PS Watanabe, HK Richters, JE Roper, M Hibbs, ED Salzberg, AD Liu, S TI Scales, diagnoses, and child psychopathology .2. Comparing the CBCL and the DISC against external validators SO JOURNAL OF ABNORMAL CHILD PSYCHOLOGY LA English DT Article ID BEHAVIOR PROBLEM SYNDROMES; PSYCHIATRIC-DIAGNOSIS; VALIDITY; CONVERGENCE; IMPAIRMENT; COMMUNITY; ANXIETY AB Using a multimethod multistage screening procedure, the authors interviewed 201 parents and their children with the Diagnostic Interview Schedule for Children (DISC 2.1), In addition, parents completed the Child Behavior Checklist (CBCL) and other survey measures, while their children completed self-report scales. Receiver operating characteristic (ROC) analyses were done to determine optimal cutpoints on the CBCL, referenced to DISC diagnostic ''caseness.'' DISC diagnoses, DISC ''stem'' symptoms, CBCL scores, and CBCL ROC-cutpoints were compared against ''external validators,'' in order to determine the comparative advantages of each approach for assessing child psychopathology. Overall findings suggest that the controversies about ''best'' assessment strategies may be artificial: When both assessment approaches are compared using similar methods, they are reasonably comparable. However, highly specific diagnostic categories may show fewer relationships with external validators and may therefore need more systematic validational studies. C1 WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,WASHINGTON,DC 20005. NIMH,DIV EPIDEMIOL & SERV RES,EPIDEMIOL & PSYCHOPATHOL RES BRANCH,ROCKVILLE,MD 20857. RP Jensen, PS (reprint author), NIMH,CHILD & ADOLESCENT DISORDERS RES BRANCH,DIV CLIN & TREATMENT RES,ROOM 18C-17,ROCKVILLE,MD 20857, USA. OI Jensen, Peter/0000-0003-2387-0650 NR 30 TC 79 Z9 79 U1 1 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0091-0627 J9 J ABNORM CHILD PSYCH JI J. Abnorm. Child Psychol. PD APR PY 1996 VL 24 IS 2 BP 151 EP 168 DI 10.1007/BF01441482 PG 18 WC Psychology, Clinical; Psychology, Developmental SC Psychology GA UK194 UT WOS:A1996UK19400002 PM 8743242 ER PT J AU Rachele, H Tunick, A Hansen, FV AF Rachele, H Tunick, A Hansen, FV TI MARIAH - A similarity-based method for determining wind, temperature, and humidity profile structure in the atmospheric surface layer - Reply SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD APR PY 1996 VL 35 IS 4 BP 613 EP 614 DI 10.1175/1520-0450(1996)035<0613:R>2.0.CO;2 PG 2 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA UL926 UT WOS:A1996UL92600010 ER PT J AU Kingsley, CP Chronister, T Cohen, DJ Parrish, JM Drew, R Bongiovanni, MB AF Kingsley, CP Chronister, T Cohen, DJ Parrish, JM Drew, R Bongiovanni, MB TI Anesthetic management of a patient with hemoglobin SS disease and mitral insufficiency for mitral valve repair SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA LA English DT Editorial Material DE sickle cell disease; transfusion; cardiopulmonary bypass ID SICKLE-CELL DISEASE; OPEN-HEART SURGERY; CARDIOPULMONARY BYPASS; TRANSFUSION; ANEMIA C1 PENN STATE UNIV,COLL MED,DEPT PATHOL,HERSHEY,PA 17033. BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,CARDIOTHORAC SURG SERV,FT SAM HOUSTON,TX 78234. ELECTROMED INC,ENGLEWOOD,CO. RP Kingsley, CP (reprint author), PENN STATE UNIV,COLL MED,DEPT ANESTHESIA,POB 850,HERSHEY,PA 17033, USA. NR 29 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1053-0770 J9 J CARDIOTHOR VASC AN JI J. Cardiothorac. Vasc. Anesth. PD APR PY 1996 VL 10 IS 3 BP 419 EP 424 DI 10.1016/S1053-0770(96)80108-X PG 6 WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System; Peripheral Vascular Disease SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System GA UG928 UT WOS:A1996UG92800022 PM 8725428 ER PT J AU Rothenberg, ML Eckardt, JR Kuhn, JG Burris, HA Nelson, J Hilsenbeck, SG Rodriguez, GI Thurman, AM Smith, LS Eckhardt, SG Weiss, GR Elfring, GL Rinaldi, DA Schaaf, LJ VonHoff, DD AF Rothenberg, ML Eckardt, JR Kuhn, JG Burris, HA Nelson, J Hilsenbeck, SG Rodriguez, GI Thurman, AM Smith, LS Eckhardt, SG Weiss, GR Elfring, GL Rinaldi, DA Schaaf, LJ VonHoff, DD TI Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CELL LUNG-CANCER; ANTITUMOR-ACTIVITY; CAMPTOTHECIN; CPT-11 AB Purpose: To evaluate irinotecan (CPT-11; Yakult Honsha, Tokyo, Japan) in patients with metastatic colorectal carcinoma that had recurred or progressed following fluorouracil (5-FU)-based therapy. Patients and Methods: Patients were treated with irinotecan 125 to 150 mg/m(2) intravenously (IV) every week for 4 weeks, followed by a 2-week rest. Forty-eight patients were entered onto the study and all were assessable for toxicity. Forty-three patients completed one full course of therapy and were assessable for response. Results: One complete and nine partial responses were observed (response rate, 23%; 95% confidence interval [CI], 10% to 36%). The median response duration was 6 months (range, 2 to 13). The median survival time was 10.4 months and the 1-year survival rate was 46% (95% CI, 39% to 53%). Grade 4 diarrhea occurred in four of the first nine patients (44%) treated on this study at the 150-mg/m(2) dose level. The study was amended to reduce the starting dose of irinotecan to 125 mg/m(2). At this dose, nine of 39 patients (23%) developed grade 4 diarrhea. Aggressive administration of loperamide also reduced the incidence of grade 4 diarrhea. Grade 4 neutropenia occurred in eight of 48 patients (17%), but was associated with bacteremia and sepsis in only one case. Conclusion: Irinotecan has significant single-agent activity against colorectal cancer that has progressed during or shortly after treatment with 5-FU-based chemotherapy. The incidence of severe diarrhea is reduced by using a starting dose of irinotecan 125 mg/m(2) and by initiating loperamide at the earliest signs of diarrhea. These results warrant further clinical evaluation to define the role of irinotecan in the treatment of individuals with colorectal cancer. (C) 1996 by American Society of Clinical Oncology. C1 CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UPJOHN CO,KALAMAZOO,MI 49001. RP Rothenberg, ML (reprint author), UNIV TEXAS,HLTH SCI CTR,DIV ONCOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. RI Schaaf, Larry/A-9417-2008 NR 25 TC 306 Z9 314 U1 3 U2 5 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR PY 1996 VL 14 IS 4 BP 1128 EP 1135 PG 8 WC Oncology SC Oncology GA UF068 UT WOS:A1996UF06800013 PM 8648367 ER PT J AU Honig, PK Wortham, DC Lazarev, A Cantilena, LR AF Honig, PK Wortham, DC Lazarev, A Cantilena, LR TI Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article ID FELODIPINE; MECHANISM AB A prospective cohort study was conducted to examine the effects of double-strength grapefruit juice on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics of terfenadine in poor metabolizers of terfenadine. Six healthy volunteers who were previously found to be poor metabolizers of terfenadine were studied, with each participant serving as his or her own control. In phase I of the study, terfenadine was given to participants at recommended dosages until steady state was achieved (60 mg twice daily for 7 days). In phase II, participants began receiving concomitant twice-daily, double-strength servings of grapefruit juice for 7 days. Serial pharmacokinetic and pharmacodynamic determinations were made after each phase of the study. The main outcome measures were serum concentrations of terfenadine and terfenadine acid metabolite, and corrected QT intervals as determined by 12-lead electrocardiogram. Significant changes occurred in time to maximum concentration (t(max)) and area under the concentration-time curve (AUG) of terfenadine and terfenadine acid metabolite after addition of grapefruit juice. All participants had detectable concentrations of unmetabolized terfenadine at the end of Phase I, which were quantified in three of the six participants. Further, all participants had increased and quantifiable levels of unmetabolized terfenadine after addition of grapefruit juice that were associated with prolongation of the QT interval relative to the baseline control period without terfenadine. Grapefruit juice did not alter the elimination half-life (t(1/2)) of terfenadine acid metabolite. Because of the intraindividual variability in the pharmacokinetics of terfenadine, further study is needed to confirm these results. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,DIV CLIN PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV CARDIOL,WASHINGTON,DC 20307. FU FDA HHS [FDA 224-88-3006] NR 27 TC 52 Z9 52 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD APR PY 1996 VL 36 IS 4 BP 345 EP 351 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UG281 UT WOS:A1996UG28100009 PM 8728348 ER PT J AU Shields, ED Mann, RW AF Shields, ED Mann, RW TI Salivary glands and human selection: A hypothesis SO JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY LA English DT Review DE polymorphism; sexual dimorphism; salt loss; infectious disease; isotherm; immuno-enhance; osteoclast; Stafne; Stafne's ID EPIDERMAL GROWTH-FACTOR; HISTIDINE-RICH POLYPEPTIDES; SUB-MANDIBULAR GLANDS; SUBMANDIBULAR GLANDS; TISSUE DISTRIBUTION; ESCHERICHIA-COLI; CANDIDA-ALBICANS; BONE-RESORPTION; BLOOD-PRESSURE; FEMALE MICE AB Stafne static bone defect (SSB) of the mandible is the only described destructive bone lesion that is highly localized, nonprogressive, but nonhealing. This common defect in males is found in the region of the major salivary glands that produce a cornucopia of biologically active factors, We describe rare phenocopies caused by mandibular immobility that hold the gland in a constant position thus implicating a localized chronic ''leak'' of an osteoclast induction factor from the major salivary glands as the pathologic agent. This finding suggests that increased salivary gland size could simulate immobility by apposing the gland to bone, thus allowing the ''leaked'' factor's gradient to have an effect. In one step, the putative genetic enlargement of a critical gland that produces many factor:, important for survival, a broad biological vista would be available to the massive potential fur both positive and negative selection. Positive selection was identified by observing a correlation between the prevalence of enhanced androgen-induced enlarged salivary glands (SSBD as a marker, with a great preponderance of males) and the conjectured resulting increased production of immunoreactive factors, with pole-to-equator isotherm and broad ranged infection clines. Negative selection was observed among the slave ancestors of African Americans for a potential embryonic homeotic mutation causing larger salivary glands in both sexes (decreased prevalence of SSBD, with an equal sex ratio). The decreased production of saliva and electrolytes diminished the salt and water depletive effects of severe diarrhea and vomiting induced by enteric diseases, which killed many slaves. Data presented suggests that SSBD is a polymorphism and a marker of selection processes that cause variation in size, or structure, of the major salivary glands. C1 MCGILL UNIV,FAC MED,DEPT HUMAN GENET,MONTREAL,PQ H3A 2B2,CANADA. USA,CENT IDENTIFICAT LAB,HICKAM AFB,HI. RP Shields, ED (reprint author), MCGILL UNIV,FAC DENT,DEPT ORAL BIOL,3640 UNIV ST,MONTREAL,PQ H3A 2B2,CANADA. NR 120 TC 8 Z9 8 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0270-4145 J9 J CRAN GENET DEV BIO JI J. Craniofac. Genet. Dev. Biol. PD APR-JUN PY 1996 VL 16 IS 2 BP 126 EP 136 PG 11 WC Anatomy & Morphology; Developmental Biology; Genetics & Heredity SC Anatomy & Morphology; Developmental Biology; Genetics & Heredity GA UM596 UT WOS:A1996UM59600007 PM 8773904 ER PT J AU Hnatiuk, O Moores, L Loughney, T Torrington, K AF Hnatiuk, O Moores, L Loughney, T Torrington, K TI Evaluation of internists' spirometric interpretations SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE pulmonary function tests; spirometry; guidelines ID STANDARDIZATION AB BACKGROUND: Correct interpretation of screening spirometry results is essential in making accurate clinical diagnoses and directing subsequent pulmonary evaluation. The general internist is largely responsible for interpreting screening spirometric tests at community hospitals. However, reports of new guidelines for screening spirometry are infrequently published in the general internal medicine literature. This can lead to incorrect interpretations. We sought to evaluate whether spirometric interpretations by a group of practicing general internists differed from those of two board-certified pulmonologists using guidelines published by the American Thoracic Society (ATS). METHODS: As part of a Continuous Quality Improvement project, all available screening spirometric tests over a 3-month period at two area community hospitals were reviewed. Only those performed on individuals age 18 or older were included in the analysis. Comparison was made between the interpretations of staff internists and those of two pulmonologists, who were blinded to the results of all other interpretations. We analyzed 110 screening spirometric tests from 84 males and 26 females. The patients ranged in age from 18 to 77 (mean 41 +/- 13 years of age). RESULTS: There was 97% concordance between the two pulmonologists' interpretations. In three cases, interpretations of only one pulmonologist agreed with those of the internists. The internists and both pulmonologists agreed in 73 cases. The majority of spirometric results in this subgroup were normal (n = 54). Both pulmonologists disagreed with internists' nomenclature in five cases, There was complete disagreement between the pulmonologists and the internists in the other 29 cases. Using the pulmonologists' interpretations as the ''gold standard,'' the sensitivity (the internists' ability to correctly identify abnormal spirometric results) was 58.8% (95% confidence interval [CI] 42.2%, 73.3%), the specificity was 81.8% (95% CI 70.0%, 89.8%), the positive predictive value was 66.7% (95% CI 49.0%, 80.9%), and the negative predictive value was 76.1% (95% CI 64.3%, 85.0%). The most common inaccurate Interpretations made by internists were ''small airways disease'' when spirometric results were normal (n = 8); ''normal'' when a restrictive pattern was present (n = 6), and ''normal'' when an abnormal flow-volume loop suggesting possible upper airway obstruction was present (n = 5) CONCLUSIONS: The spirometric interpretations of a group of general internists differed significantly from those of two board-certified pulmonologists using published guidelines in approximately one third of cases. This may be because subspecialty guidelines are infrequently published in the general internal medicine literature. We believe that wider dissemination of these interpretative guidelines and ongoing physician education would improve general internists' ability to identify patients who require further pulmonary evaluation. RP Hnatiuk, O (reprint author), WALTER REED ARMY MED CTR,PULM DIAGNOST SERV,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 11 TC 18 Z9 19 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 1996 VL 11 IS 4 BP 204 EP 208 DI 10.1007/BF02642476 PG 5 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA UF754 UT WOS:A1996UF75400002 PM 8744877 ER PT J AU Francis, ML Fan, XYS Meltzer, MS AF Francis, ML Fan, XYS Meltzer, MS TI Loss of ability to produce IFN-alpha in response to HIV-1 as monocytes differentiate into macrophages - Induction through a mechanism independent of double-stranded RNA SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; HERPES-SIMPLEX VIRUS; NECROSIS-FACTOR-ALPHA; INTERFERON-ALPHA; PERIPHERAL-BLOOD; KAPOSIS SARCOMA; INFECTED MONOCYTES; HOMOSEXUAL MEN; SENDAI VIRUS AB IFN-alpha is an antiviral cytokine detected in plasma of HIV-1-infected patients during acute viremia and during late-stage disease. Monocytes produced IFN-alpha in response to HIV-1: 1) IFN-alpha was produced predominantly by adherent cells; 2) depleting CD14(+) cells nearly abolished HIV-1-induced IFN-alpha production; and 3) intracytoplasmic IFN-alpha was detected in CD14(+) cells. During cell culture, monocytes differentiated into macrophages and lost their ability to produce IFN-alpha when challenged with HIV-1. These cells remained capable of producing IFN-alpha in response to other stimuli such as poly(I:C), a synthetic dsRNA. Thus, we examined two negative-stranded RNA viruses that have dsRNA intermediates, Newcastle disease virus and Sendai virus, and a DNA virus, herpes simplex virus type 1 (HSV-1). Macrophages lost their ability to produce IFN-1 in response to HSV-1, but not to Sendai virus or to Newcastle disease virus, Thus, HIV-1 and other viruses were capable of inducing IFN-alpha through a mechanism that was independent of dsRNA, In conclusion, these data suggest that there are dsRNA-dependent and -independent mechanisms for the induction of IFN-alpha production, and that as monocytes differentiate into macrophages, they selectively lose their ability to produce IFN-alpha through the dsRNA-independent mechanism. C1 WALTER REED ARMY MED CTR,RES INST,WASHINGTON,DC 20307. KAISER PERMANENTE GRP,BALTIMORE,MD 21244. RP Francis, ML (reprint author), WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MED,RHEUMATOL SECT,MED CTR BLVD,WINSTON SALEM,NC 27157, USA. NR 62 TC 11 Z9 11 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 1996 VL 156 IS 7 BP 2481 EP 2487 PG 7 WC Immunology SC Immunology GA UB155 UT WOS:A1996UB15500022 PM 8786308 ER PT J AU Wong, MT Dolan, MJ Kozlow, E Doe, R Melcher, GP Burke, DS Boswell, RN Vahey, M AF Wong, MT Dolan, MJ Kozlow, E Doe, R Melcher, GP Burke, DS Boswell, RN Vahey, M TI Patterns of virus burden and T cell phenotype are established early and are correlated with the rate of disease progression in human immunodeficiency virus type 1-infected persons SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HIV-1 INFECTION; PERIPHERAL-BLOOD; PROGNOSTIC VALUE; LYMPHOCYTES-T; CD4+; EXPRESSION; CD26; INDIVIDUALS; ACTIVATION; PLASMA AB Human immunodeficiency virus (HIV)-1 DNA and RNA levels and T lymphocyte cell surface markers were measured in blood serum and cell fractions from asymptomatic infected patients to find novel virologic and immunologic features in early disease predictive of subsequent clinical disease course, Thirty-two patients with rapid disease progression (rapid CD4(+) cell loss and progression to clinical AIDS) were compared with 25 patients with stable infections (constant or rising CD4(+) cell counts, no clinical disease manifestations). All HIV-1 burdens measured by polymerase chain reaction were consistently higher in specimens from rapid progressors than slow progressors. For each patient, virus burden remained relatively constant throughout the study period (mean, 42-44 months), Flow cytometry also disclosed stable lymphocyte immunophenotype patterns that correlated strongly with subsequent rapid progression to clinical disease, Thus, in early HIV-1 infection, a constellation of high virus burden and in vivo costimulatory antigen and lymphocyte activation abnormalities is predictive of a rapid disease course. C1 WILFORD HALL USAF MED CTR,DEPT ALLERGY & IMMUNOL,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,DEPT PATHOL,LACKLAND AFB,TX 78236. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. RP Wong, MT (reprint author), WILFORD HALL USAF MED CTR,DEPT INFECT DIS,2200 BERGQUIST DR,SUITE 1,LACKLAND AFB,TX 78236, USA. OI /0000-0002-5704-8094 NR 46 TC 42 Z9 42 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1996 VL 173 IS 4 BP 877 EP 887 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UB274 UT WOS:A1996UB27400013 PM 8603966 ER PT J AU Savarino, SJ McVeigh, A Watson, J Cravioto, A Molina, J Echeverria, P Bhan, MK Levine, MM Fasano, A AF Savarino, SJ McVeigh, A Watson, J Cravioto, A Molina, J Echeverria, P Bhan, MK Levine, MM Fasano, A TI Enteroaggregative Escherichia coli heat-stable enterotoxin is not restricted to enteroaggregative E-coli SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ENTEROPATHOGENIC SEROTYPES; DIARRHEA AB Enteroaggregative Escherichia coli (EAggEC) have been implicated as diarrheal pathogens in several settings, Some EAggEC produce a distinct heat-stable enterotoxin named EAST1, The distribution and prevalence of the EAST1 gene in selected groups of bacterial enteropathogens were determined by colony hybridization, One hundred percent of 75 O157:H7 enterohemorrhagic E. coli (EHEC), 41% of 227 EAggEC, 41% of 149 enterotoxigenic E. coli, 22% of 65 enteropathogenic E. coli (EPEC), and 38% of 47 E. coli stool isolates from asymptomatic children hybridized with an EAST1 DNA probe, None of 55 enteroinvasive E. coli, 12 Yersinia enterocolitica, or 20 Vibrio cholerae non-O1 strains were EAST1 probe-positive, Concordance between EAST1 genotype and enterotoxicity was shown in examined strains of EAggEC, EHEC, and EPEC, The gene encoding EAST1 is more broadly distributed among diarrheogenic E. coli than previously known and may represent an additional determinant in the pathogenesis of E. coli diarrhea. C1 USN, MED RES INST, ENTER DIS PROGRAM, BETHESDA, MD USA. UNIV MARYLAND, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21201 USA. UNIV MARYLAND, SCH MED, DEPT MED, BALTIMORE, MD 21201 USA. UNIV NACL AUTONOMA MEXICO, DEPT PUBL HLTH, MEXICO CITY, DF, MEXICO. ARMED FORCES RES INST MED SCI, DEPT BACTERIOL, BANGKOK 10400, THAILAND. UNIV MARYLAND, SCH MED, CTR VACCINE DEV, BALTIMORE, MD 21201 USA. ALL INDIA INST MED SCI, DEPT PEDIAT, NEW DELHI, INDIA. NR 15 TC 139 Z9 140 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1996 VL 173 IS 4 BP 1019 EP 1022 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UB274 UT WOS:A1996UB27400035 PM 8603943 ER PT J AU Ding, XZ Smallridge, RC Galloway, RJ Kiang, JG AF Ding, XZ Smallridge, RC Galloway, RJ Kiang, JG TI Increases in HSF1 translocation and synthesis in human epidermoid A-431 cells: Role of protein kinase C and [Ca2+](i) SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Article DE heat shock proteins; heat shock factor; protein kinase C; calcium; epithelia ID HEAT-SHOCK FACTOR; GROWTH-FACTOR RECEPTOR; CYTOSOLIC FREE CA2+; TRANSCRIPTION FACTOR; MESSENGER-RNA; DNA-BINDING; HUMAN HSP70; FACTOR-II; ACTIVATION; EXPRESSION AB Background: It is known that heat shock increases both heat shock protein 70 kd (HSP-70), mRNA synthesis, and intracellular cytosolic free calcium concentration ([Ca2+](i)) The latter enhances the heat inducible form of HSP-70 production by increasing the complex formation between heat shock transcriptional factor (HSF) and heat shock elements (HSE). In this study, we investigated the effect of agonists (PMA; ionomycin) and antagonists (BAPTA; staurosporine) of protein kinase C (PKC), and calcium channel on translocation and synthesis of HSF1, and activation of HSP-70 gene in human epidermoid A-431 cells. Methods: Cells were incubated with poly 12-myristate 13-acetate (PMA) or ionomycin at different concentrations for various periods of time, Messenger RNAs of HSF and HSP-70 were measured with RT-PCR. The HSP-70 protein was determined with Western blots, and HSF protein was measured by gel mobility retardation assay. Results: Significant increases in HSF binding to [P-32]labeled HSE were found at 30 minutes in nuclear extract and at 4 hours in both nuclear and cytosol extracts, The PMA- and ionomycin-induced increases in HSF were in a concentration-dependent manner with a maximal increase at 10(-6) mol/L of each drug. Meanwhile, the mRNAs encoded for HSF1 and HSP-70, but not HSF2, were significantly increased and reached the maximum at 1 hour after the treatment. The PMA increased [Ca2+](i) by 92% because of Ca2+ influx. The increases in mRNA of HSF1 and HSP-70 induced by treatment with 1 mu mol/L PMA were completely blocked by preincubating cells with either 2 mu mol/L staurosporine in the presence of extracellular Ca2+ or 100 mu mol/L BAPTA-am in absence of extracellular Ca2+. Like PMA, the increases induced by ionomycin were also inhibited by 100 mu mol/L BAPTA-am in absence of extracellular Ca2+ Furthermore, Western blots show that 1 mu mol/L PMA or ionomycin induced maximal increase in HSP-70 after 7 hours of continuous incubation with either agent. When cells were simultaneously treated with 1 mu mol/L PMA and ionomycin together for 1 hour, the increase in HSP-70 and HSF1 mRNAs reached a greater level than the level stimulated by either drug alone. Conclusions: These results indicate that both PMA and ionomycin stimulate HSF1, but not HSF2, translocation and synthesis leading to the HSP-70 expression and that their effects are Ca2+-dependent. C1 WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 41 TC 59 Z9 60 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD APR PY 1996 VL 44 IS 4 BP 144 EP 153 PG 10 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA UF743 UT WOS:A1996UF74300007 PM 8689410 ER PT J AU Ballato, J Dejneka, M Riman, RE Snitzer, E Zhou, WM AF Ballato, J Dejneka, M Riman, RE Snitzer, E Zhou, WM TI Sol-gel synthesis of rare-earth-doped fluoride glass thin films SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID MULTIPHONON RELAXATION; IONS AB This paper describes ZBLA fluoride glass thin films produced via an inexpensive, low-temperature reactive atmosphere sol-gel approach. Luminescence from erbium at 1.55 mu m has been observed in x-ray-amorphous doped films deposited on calcium fluoride, polyimide, sapphire, and silicon substrates. Fluorescence studies of the erbium S-4(3/2) --> I-4(13/2) transition, a characteristic emission for a reduced phonon energy host, were conducted for both sol-gel-derived films and conventionally prepared glass rods. The peak intensity observed from the sol-gel films was blue-shifted by 16 nm with a FWHM value approximately half that measured for the melt-quenched rods. Excitation studies indicate that, unlike conventionally prepared glasses, sol-gel materials suffer from nonradiative relaxation of the S-4(3/2) excited state to the I-4(9/2) level, where subsequent radiative emission to the I-4(15/2) ground state occurs. The proposed source of the quenching mechanism are remnant species inherent to the sol-gel process. While this causes the luminescence behavior of rare-earth-doped sol-gel-derived fluoride materials to be similar to oxide hosts, these remnant species modify the branching ratios, resultantly leading to a novel 824 nn emission when excited at 488 nm. C1 USA,RES LAB,PHYS SCI DIRECTORATE,AMSRL,PS,P,FT MONMOUTH,NJ 07703. RP Ballato, J (reprint author), RUTGERS STATE UNIV,FIBER OPT MAT RES PROGRAM,PISCATAWAY,NJ 08855, USA. NR 40 TC 22 Z9 24 U1 1 U2 5 PU MATERIALS RESEARCH SOCIETY PI PITTSBURGH PA 9800 MC KNIGHT ROAD SUITE 327, PITTSBURGH, PA 15237 SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD APR PY 1996 VL 11 IS 4 BP 841 EP 849 DI 10.1557/JMR.1996.0102 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA UE459 UT WOS:A1996UE45900009 ER PT J AU SARNECKY, MT AF SARNECKY, MT TI SHANGRI-LA FOR WOUNDED SOLDIERS - THE GREENBRIER AS A WORLD-WAR-II ARMY HOSPITAL - KEEFER,LE SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP SARNECKY, MT (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1996 VL 60 IS 2 BP 391 EP 392 DI 10.2307/2944438 PG 2 WC History SC History GA UE880 UT WOS:A1996UE88000039 ER PT J AU Rao, DVGLN Aranda, FJ Chen, Z Akkara, JA Kaplan, DL Nakashima, M AF Rao, DVGLN Aranda, FJ Chen, Z Akkara, JA Kaplan, DL Nakashima, M TI Nonlinear optical studies of bacteriorhodopsin SO JOURNAL OF NONLINEAR OPTICAL PHYSICS & MATERIALS LA English DT Article; Proceedings Paper CT 2nd Mediterranean Workshop and Topical Meeting on Novel Optical Materials and Applications (NOMA) CY MAY 28-JUN 02, 1995 CL CETRARO, ITALY ID FILMS AB We report interesting results on nonlinear optics at low powers in bacteriorhodopsin films with applications in all-optical switching and modulation. Chemically stabilized films of bacteriorhodopsin in a polymer matrix for which the lifetime of the excited M state is 3 to 4 orders of magnitude longer than that of water solutions of wild-type bR were used in these experiments. Due to the sensitivity of the films, very small powers of order microwatts are required for optical phase conjugation. The influence of the fast photochemical M to B transition induced by blue light on the saturation intensity, phase conjugate intensity and switching time was established. We also report our measurements of the intensity dependence of the self-focusing and self-defocusing properties of wildtype bR in water solution using the Z-scan technique with low power cw lasers at two wavelengths on either side of the absorption band. Our measurements indicate that the sign of the nonlinearity depends on the wavelength and the magnitude depends on the fluence of the incident laser beam. The observed self-focusing and defocusing is not due to the intrinsic electronic nonlinearity. The observations can be explained in terms of the Kramers-Kronig dispersion relation that relates the real and imaginary parts of the complex index of refraction. C1 USA, NATICK RES DEV & ENGN CTR, NATICK, MA 01760 USA. RP UNIV MASSACHUSETTS, DEPT PHYS, BOSTON, MA 02125 USA. RI Rao, Devulapalli/L-8863-2015 NR 31 TC 5 Z9 5 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-8635 EI 1793-6624 J9 J NONLINEAR OPT PHYS JI J. Nonlinear Opt. Phys. Mater. PD APR PY 1996 VL 5 IS 2 BP 331 EP 349 DI 10.1142/S0218863596000210 PG 19 WC Optics; Physics, Applied SC Optics; Physics GA UW541 UT WOS:A1996UW54100009 ER PT J AU Taylor, JC Driscoll, CF Cunningham, MD AF Taylor, JC Driscoll, CF Cunningham, MD TI Failure of a hydroxyapatite-coated endosteal dental implant: A clinical report SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID BONE C1 WALTER REED ARMY MED CTR,POSTGRAD PROSTHODONT PROGRAM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PROSTHODONT,WASHINGTON,DC 20307. NR 26 TC 9 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1996 VL 75 IS 4 BP 353 EP 355 DI 10.1016/S0022-3913(96)90023-2 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UD918 UT WOS:A1996UD91800001 PM 8642517 ER PT J AU Crosier, RB AF Crosier, RB TI Symmetric orientations for simplex designs SO JOURNAL OF QUALITY TECHNOLOGY LA English DT Article DE design of experiments; Plackett-Burman designs; response surface methodology; simplex designs AB Designs for fitting first-order response surfaces over spherical regions are often constructed from the vertices of regular geometric figures. The well-known method of generating a simplex design for any number of factors gives the factors unequal, asymmetric ranges. The unequal, asymmetric ranges of the coded design factors create a problem in applying the designs: the geometric and statistical properties of the design must be distorted to give the experimental factors the desired ranges. Symmetric orientations are given for the simplex designs for 4-6, 8-10, 12, and 13 factors. In the new orientations, the simplex designs have up to six levels of the factors. RP Crosier, RB (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0022-4065 J9 J QUAL TECHNOL JI J. Qual. Technol. PD APR PY 1996 VL 28 IS 2 BP 148 EP 152 PG 5 WC Engineering, Industrial; Operations Research & Management Science; Statistics & Probability SC Engineering; Operations Research & Management Science; Mathematics GA UG930 UT WOS:A1996UG93000002 ER PT J AU Grant, KW Walden, BE AF Grant, KW Walden, BE TI Spectral distribution of prosodic information SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE prosody; spectral cues; speech recognition; auditory-visual speech recognition ID SENSORINEURAL HEARING-LOSS; CONSONANT RECOGNITION; FUNDAMENTAL-FREQUENCY; AMPLITUDE ENVELOPE; IMPAIRED ADULTS; SINGLE-CHANNEL; SPEECH; PERCEPTION; CUES; AID AB Prosodic speech cues for rhythm, stress, and intonation are related primarily to variations in intensity, duration, and fundamental frequency. Because these cues make use of temporal properties of the speech waveform they are likely to be represented broadly across the speech spectrum. In order to determine the relative importance of different frequency regions for the recognition of prosodic cues, identification of four prosodic features, syllable number, syllabic stress, sentence intonation, and phrase boundary location, was evaluated under six filter conditions spanning the range from 200-6100 Hz. Each filter condition had equal articulation index (AI) weights, AI = 0.10; p(C)(isolated words) approximate to 0.40. Results obtained with normally hearing subjects showed that there was an interaction between filter condition and the identification of specific prosodic features. For example, information from high-frequency regions of speech was particularly useful in the identification of syllable number and stress, whereas information from low-frequency regions was helpful in identifying intonation patterns. In spite of these spectral differences, overall listeners performed remarkably well in identifying prosodic patterns, although individual differences were apparent. For some subjects, equivalent levels of performance across the six filter conditions were achieved. These results are discussed in relation to auditory and auditory-visual speech recognition. RP Grant, KW (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00792] NR 54 TC 27 Z9 27 U1 2 U2 5 PU AMER SPEECH-LANG-HEARING ASSN PI ROCKVILLE PA 10801 ROCKVILLE PIKE RD, ROCKVILLE, MD 20852-3279 SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD APR PY 1996 VL 39 IS 2 BP 228 EP 238 PG 11 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA UE601 UT WOS:A1996UE60100001 PM 8729913 ER PT J AU Jensen, PS Martin, D Watanabe, H AF Jensen, PS Martin, D Watanabe, H TI Children's response to parental separation during Operation Desert Storm SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE parental absence; father absence; military children; stress ID MANIFEST ANXIETY; MILITARY FAMILY; I THINK; STRESS; RISK; FEEL; WAR AB Objective: Commonly held attitudes concerning the effects of parental wartime deployment on children have usually been guided by stereotype, rather than scientific data. To determine the effects of Operation Desert Storm on military children and their parents, the authors compared children and families with and without a deployed soldier-parent prior to and during Operation Desert Storm. Method: Three hundred eighty-three children and the remaining caretaking parent completed self- and parent-report instruments concerning child and family functioning and life stressors. Children of deployed and nondeployed personnel were compared cross-sectionally, as well as longitudinally, using data collected prior to any knowledge of Operation Desert Storm. Results: Children of deployed personnel experienced elevated self-reported symptom levels of depression, as did their parents. Likewise, families of deployed personnel reported significantly more intervening stressors, compared with children and families of nondeployed personnel. However, deployment per se rarely provoked pathological levels of symptoms in otherwise healthy children. Conclusions: Generally, the factors shaping differential outcomes among children of deployed personnel do not differ from the variables affecting outcomes of children of nondeployed parents. However, boys and younger children appear to be especially vulnerable to deployment effects, and increased monitoring of these children is warranted. Adequate treatment of children requires treatment of the effects of the deployment on other family members. For children showing more persistent or pervasive psychopathology, factors other than simple deployment should be considered. C1 CITADEL COLL,CHARLESTON,SC. WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,DEPT MIL PSYCHIAT,WASHINGTON,DC. RP Jensen, PS (reprint author), NIMH,CHILD & ADOLESCENT DISORDERS RES BRANCH,5600 FISHERS LANE,ROCKVILLE,MD 20857, USA. OI Jensen, Peter/0000-0003-2387-0650 NR 24 TC 93 Z9 93 U1 5 U2 10 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD APR PY 1996 VL 35 IS 4 BP 433 EP 441 DI 10.1097/00004583-199604000-00009 PG 9 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA UB759 UT WOS:A1996UB75900009 PM 8919705 ER PT J AU English, JC McCollough, ML AF English, JC McCollough, ML TI Transient reactive papulotranslucent acrokeratoderma SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article RP English, JC (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,BLDG 1053,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 55 Z9 59 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD APR PY 1996 VL 34 IS 4 BP 686 EP 687 DI 10.1016/S0190-9622(96)80087-9 PG 2 WC Dermatology SC Dermatology GA UC798 UT WOS:A1996UC79800019 PM 8601664 ER PT J AU Carter, AJ Laird, JR Kufs, WM Bailey, L Hoopes, TG Reeves, T Farb, A Virmani, R AF Carter, AJ Laird, JR Kufs, WM Bailey, L Hoopes, TG Reeves, T Farb, A Virmani, R TI Coronary stenting with a novel stainless steel balloon-expandable stent: Determinants of neointimal formation and changes in arterial geometry after placement in an atherosclerotic model SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID RESTENOSIS; PROLIFERATION; ANGIOPLASTY; INJURY AB Objectives. This study evaluated the delivery characteristics and vascular response to placement of a novel balloon-expandable stent in swine with experimentally induced atherosclerosis. Background. The Multi-Link stent is a balloon expandable stainless steel stent with an interconnected ring structure designed to provide a high degree of compressive resistance while preserving longitudinal flexibility. The placement characteristics and vascular response to this stent in atherosclerotic coronary arteries have not been characterized. Methods. We tested the delivery characteristics and vascular response to the Multi Link stent in 19 miniature swine with experimentally induced coronary atherosclerosis created in 37 coronary artery segments by overstretch balloon injury and high cholesterol diet. Quantitative coronary angiography was used to define stent performance characteristics, such as lesion dilation and compressive resistance. Pathologic assessment of the stented arteries was used to evaluate the immediate and long-term vascular response to stent placement. Results. Nineteen (95%) of 20 stents were successfully implanted in the left anterior descending (n = 11), left circumflex (n = 7) or right (n = 1) coronary artery. The baseline angiographic minimal lumen diameter of the stented coronary segment was 2.48 +/- 0.09 mm (reference diameter 2.87 +/- 0.06 mm, mean +/- SE) and increased to 2.82 +/- 0.05 mm (p < 0.001) after stent placement. The balloon-inflated stent diameter was 2.98 +/- 0.06 mm with minimal recoil to a final minimal lumen diameter of 2.82 +/- 0.06 mm at 15 min after implantation (p = 0.001). Angiographic and histologic follow-up at 72 h (n = 7), 14 days (n = 4) and 56 days (n = 8) demonstrated that all stents were patent, without evidence of migration, intraluminal filling defects or side branch occlusion, At 56 days, mean neointimal thickness was significantly greater at the stent sire sites in the region of the plaque where the media was absent than the stent wire sites, where the internal elastic lamina was intact with underlying normal media (0.48 +/- 0.01 vs. 0.27 +/- 0.02 mm, p < 0.0001). Compared with the nonstented atherosclerotic lesions, after 56 days the stented vessels had a mildly reduced lumen area when normalized to the proximal reference vessel (2.81 +/- 0.27 vs. 2.68 +/- 0.30 mm(2), p = 0.07). The mean change in the area within the external elastic lamina relative to a normal proximal reference segment was significantly greater in stented vessels (1.45 +/- 0.34 mm(2)) than nonstented atherosclerotic vessels (0.44 +/- 0.28 mm(2), p = 0.033). Conclusions. Morphologic data confirm that the principal beneficial effect of stent placement is vessel expansion and attenuation of constrictive remodeling. In vessels with eccentric atherosclerotic fibrocellular plaques, the presence of normal media underlying the stent determines the degree of neointimal formation. These data may be useful in understanding the mechanism of stent restenosis in patients with prior percutaneous transluminal coronary angioplasty. C1 WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC 20307. ADV CARDIOVASC SYST INC,SANTA CLARA,CA. USA,ARMED FORCES INST PATHOL,WASHINGTON,DC 20310. RP Carter, AJ (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307, USA. NR 23 TC 40 Z9 44 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR PY 1996 VL 27 IS 5 BP 1270 EP 1277 DI 10.1016/0735-1097(95)00584-6 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA UD651 UT WOS:A1996UD65100045 PM 8609355 ER PT J AU Walker, CW Cox, JD Salomon, M AF Walker, CW Cox, JD Salomon, M TI Conductivity and electrochemical stability of electrolytes containing organic solvent mixtures with lithium tris(trifluoromethanesulfonyl)methide SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article AB The effort to develop improved electrolytes which satisfy the requirements of a high voltage lithium rechargeable battery has prompted the search for new conductive salts which are thermally and electrochemically stable. We have identified a ternary solvent mixture containing the electrolyte lithium tris(trifluoromethanesulfonyl)methide, LiC(CF3SO2)(3), that is conductive and electrochemically stable at cell potentials exceeding 4.0 V. Ionic conductivities were measured between -30 and 55 degrees C, and electrochemical stability determined by cyclic voltammetry on glassy carbon, platinum, and aluminum substrates. RP Walker, CW (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,CHEM BIOSCI DIV,FT MONMOUTH,NJ 07703, USA. NR 6 TC 28 Z9 30 U1 0 U2 13 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD APR PY 1996 VL 143 IS 4 BP L80 EP L82 DI 10.1149/1.1836607 PG 3 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA UF815 UT WOS:A1996UF81500005 ER PT J AU Andrews, LC Young, CY Miller, WB AF Andrews, LC Young, CY Miller, WB TI Coherence properties of a reflected optical wave in atmospheric turbulence SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID GAUSSIAN BEAMS; PROPAGATION; FLUCTUATIONS; SPECTRUM; SYSTEMS; MODEL AB The transverse spatial coherence radius is studied for both the monostatic and bistatic laser radar problems involving an optical wave propagating through atmospheric turbulence in the weak-fluctuation regime over a path of length L and then reflected in the reverse direction from a finite mirror with finite focal length F-R. Formal expressions are developed for the wave structure function and the modulus of the complex degree of coherence in the general Gaussian-beam wave ease, and tractable analytic results are derived for the special case of a diverging (or spherical) wave at the transmitter and observation points in the beam symmetrically located with respect to the beam centerline. By varying the focal length of the mirror, one minimizes the spatial coherence radius of a reflected spherical. wave when the receiver is located near the plane defined by the radius of curvature of the mirror (i.e., L/F-R similar to 2) and maximizes it when L/F-R is approximately 6-7. Effects of inner scale, outer scale, and the high wave-number deviation from pure power-law behavior are taken into account in the assumed spectral models for refractive-index fluctuations. Analogous to line-of-sight propagation, the spatial coherence radius based on a modified spectrum is generally less than that based on the von Karman spectrum, particularly when the coherence radius is of the order of the inner scale of turbulence. (C) 1996 Optical Society of America C1 UNIV CENT FLORIDA, CTR RES & EDUC OPT & LASERS, ORLANDO, FL 32816 USA. UNIV WASHINGTON, DEPT APPL MATH, SEATTLE, WA 98195 USA. USA, RES LAB, BATTLEFIELD ENVIRONM DIRECTORATE, WHITE SANDS MISSILE RANGE, NM 88002 USA. RP UNIV CENT FLORIDA, DEPT MATH, ORLANDO, FL 32816 USA. NR 22 TC 6 Z9 8 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD APR PY 1996 VL 13 IS 4 BP 851 EP 861 DI 10.1364/JOSAA.13.000851 PG 11 WC Optics SC Optics GA UB623 UT WOS:A1996UB62300020 ER PT J AU Rozanski, TA AF Rozanski, TA TI Inverted papilloma: An unusual recurrent, multiple and multifocal lesion SO JOURNAL OF UROLOGY LA English DT Article DE bladder; bladder neoplasms; papilloma ID BLADDER RP Rozanski, TA (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 12 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 1996 VL 155 IS 4 BP 1391 EP 1391 DI 10.1016/S0022-5347(01)66280-3 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA TZ330 UT WOS:A1996TZ33000076 PM 8632588 ER PT J AU Choi, CS Sharpe, W Barker, J Fields, RJ AF Choi, CS Sharpe, W Barker, J Fields, RJ TI Neutron diffraction study of austempered ductile iron SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article AB Crystallographic properties of an austempered ductile iron (ADI) were studied by using neutron diffraction. A quantitative phase analysis based on Rietveld refinements revealed three component phases, alpha-Fe (ferrite), gamma-Fe (austenite), and graphite precipitate, with weight fractions of 66.0, 31.5, and 2.5 pct, respectively. The ferrite phases of the samples were found to be tetragonal, I4/mmm, with a c/a ratio of about 0.993, which is very close to the body-centered cubic (bcc) structure; The austenite phase had C atoms occupying the octahedral site of the face-centered cubic (fee) unit cell with about 8 pct occupancy ratio, A strong microstrain broadening was observed for the two Fe phases of the samples. The particle sizes of the acicular ferrite phase were studied by using small angle neutron scattering. The analysis suggested a mean rod diameter of 700 Angstrom. The scattering invariant predicts a ferrite volume fraction consistent with the powder diffraction analysis. A textbook case of nodular graphite segregation, with average diameters ranging from 10 to 20 mu m, was observed by optical micrography. C1 NATL INST STAND & TECHNOL,MAT SCI & ENGN LAB,GAITHERSBURG,MD 20899. RP Choi, CS (reprint author), USA,ARMAMENT RES DEV & ENGN CTR,PICATINNY ARSENAL,NJ 07806, USA. NR 14 TC 3 Z9 3 U1 0 U2 2 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD APR PY 1996 VL 27 IS 4 BP 923 EP 928 DI 10.1007/BF02649759 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA UG103 UT WOS:A1996UG10300011 ER PT J AU Meitzler, T Gerhart, G Singh, H AF Meitzler, T Gerhart, G Singh, H TI On modification of the relative complexity metric SO MICROELECTRONICS AND RELIABILITY LA English DT Article AB Software reliability and software complexity are closely related issues in software development. An elegant definition of relative complexity was proposed in [1, 2]. The definition given in [1, 2] needs modification. Depending on how many factor loadings are used in the factor analysis different complexity results are obtained. Hence the definition of relative complexity given in those papers is subjective. The object of this paper is to suggest a modified definition of relative complexity. Different measures based on the magnitude of the eigenvalues obtained from the correlation matrix are suggested in this paper. The relative complexity of 27 programs given in [3] has been calculated using different factor loadings. C1 WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48092. RP Meitzler, T (reprint author), USA,TANK AUTOMOT & ARMAMENTS COMMAND SURVIVABIL TECHN,RES & ENGN CTR,TARDEC,WARREN,MI 48397, USA. RI Meitzler, Thomas/D-1065-2017 NR 3 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD APR PY 1996 VL 36 IS 4 BP 469 EP 475 DI 10.1016/0026-2714(95)00121-2 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA UA439 UT WOS:A1996UA43900003 ER PT J AU Bamberger, PK AF Bamberger, PK TI New York-tidewater chapters history of military medicine essay award - The adoption of laparotomy for the treatment of penetrating abdominal wounds in war SO MILITARY MEDICINE LA English DT Article RP Bamberger, PK (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 45 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1996 VL 161 IS 4 BP 189 EP 196 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA UF516 UT WOS:A1996UF51600002 PM 8935504 ER PT J AU Ferguson, A Bolouri, H AF Ferguson, A Bolouri, H TI Improving reinforcement learning in stochastic RAM-based neural networks SO NEURAL PROCESSING LETTERS LA English DT Article DE hardware realisation; RAM-based nodes; reinforcement learning; reward-penalty AB RAM-based neural networks are designed to be efficiently implemented in hardware. The desire to retain this property influences the training algorithms used, and has led to the use of reinforcement (reward-penalty) learning. An analysis of the reinforcement algorithm applied to RAM-based nodes has shown the ease with which unlearning can occur. An amended algorithm is proposed which demonstrates improved learning performance compared to previously published reinforcement regimes. C1 UNIV HERTFORDSHIRE,ERDC,HATFIELD AL10 9AB,HERTS,ENGLAND. NR 7 TC 0 Z9 0 U1 2 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1370-4621 J9 NEURAL PROCESS LETT JI Neural Process. Lett. PD APR PY 1996 VL 3 IS 1 BP 11 EP 15 DI 10.1007/BF00417784 PG 5 WC Computer Science, Artificial Intelligence; Neurosciences SC Computer Science; Neurosciences & Neurology GA VB250 UT WOS:A1996VB25000003 ER PT J AU Tortella, FC Hill, RG AF Tortella, FC Hill, RG TI EEG seizure activity and behavioral neurotoxicity produced by (+)-MK801, but not the glycine site antagonist L-687,414, in the rat SO NEUROPHARMACOLOGY LA English DT Article DE L-687,414; (+)-MK801; (+)-HA966; N-methyl-D-aspartate (NMDA); glycine; EEG seizures; behavioral neurotoxicity ID D-ASPARTATE RECEPTOR; NMDA RECEPTOR; GLUCOSE-UTILIZATION; ANTICONVULSANT; HA-966; MK-801 AB The objective of the present study was to compare the in vivo effects of the anticonvulsant/neuroprotective glycine-site partial agonists L-687,414 (3R-amino-1-hydroxy-4R-methylpyrrolidin-2-one) and (+)-HA966 (3-Amino-1-hydroxypyrrolidin-2-one) and the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK801 on spontaneous cortical EEG activity and behavior in the unanesthetized rat. Comprehensive dose-response assessments demonstrated that acute i.v. injections of (+)-MK801 induced a behavioral neurotoxic syndrome comprised of head-weaving, ataxia, hyperlocomotion and myoclonic/clonic behaviors and associated with disruptions in normal EEG rhythms including paroxysmal EEG spike/wave complexes. Injections of (+)-HA966 produced behavioral sedation associated with high-amplitude, slow-wave synchronized EEG patterns; signs of ictal EEG activity were minimal (33% incidence) and only seen at the highest dose tested (100 mg/kg). Both (+)-MK801 and (+)-HA966 severely delayed the latency to slow-wave sleep (SWS). In contrast, the EEG dynamics and overt behavior associated with L687,414 were essentially indistinguishable from controls. There was no disruption in the latency to SWS and mild ataxia was evident only upon awakening. The calculated protective indices (EEG seizure ED(50)/anticonvulsant ED(50)) for (+)-MK801 and L-687,414 were 1.2 and >4.5, respectively. The results of this study confirm that valuable pharmacological actions mediated via glycine site modulation of the NMDA receptor are possible without the clinical manifestation of unwanted neurotoxic side-effects. Published by Elsevier Science Ltd 1996. C1 MERCK SHARP & DOHME RES LABS,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND. RP Tortella, FC (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT NEUROPHARMACOL,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 24 TC 15 Z9 17 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0028-3908 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD APR PY 1996 VL 35 IS 4 BP 441 EP 448 DI 10.1016/0028-3908(95)00190-5 PG 8 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA UT502 UT WOS:A1996UT50200007 PM 8793906 ER PT J AU Luchetti, JM Lee, WQ Uyehara, CFT AF Luchetti, JM Lee, WQ Uyehara, CFT TI Acute hypoxia increases pulmonary artery inducible nitric oxide synthase in neonatal piglets. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. UNIV HAWAII,KAPIOLANI MED CTR,HONOLULU,HI 96822. UNIV HAWAII,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 362 EP 362 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23800362 ER PT J AU McClellan, DR Welch, CA Svec, RL Ellison, B Tuttle, RM Robie, DK Francis, GL AF McClellan, DR Welch, CA Svec, RL Ellison, B Tuttle, RM Robie, DK Francis, GL TI Local metastasis at the time of initial diagnosis of thyroid cancer. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 542 EP 542 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23800543 ER PT J AU Welch, CA McClellan, DR Svec, RL Ellison, B Tuttle, RM Robie, DK Francis, GL AF Welch, CA McClellan, DR Svec, RL Ellison, B Tuttle, RM Robie, DK Francis, GL TI Differentiated thyroid cancer may have genetic determinants. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 587 EP 587 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23800587 ER PT J AU Berkenbaugh, JT Palacino, JJ ONeill, JT AF Berkenbaugh, JT Palacino, JJ ONeill, JT TI Inhibition of nitric oxide synthase affects cerebral cortical blood flow during hypertension in newborn piglets. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 1157 EP 1157 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23801157 ER PT J AU Meister, JC Patrinos, ME Rubin, BK Balaraman, V Sood, SL Finn, KC Ku, T Easa, D AF Meister, JC Patrinos, ME Rubin, BK Balaraman, V Sood, SL Finn, KC Ku, T Easa, D TI Alteration of physical, and transport properties of meconium by Exosurf(R). SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,DEPT PEDIAT,HONOLULU,HI. UNIV HAWAII,TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96822. ST LOUIS UNIV,DEPT PEDIAT,ST LOUIS,MO 63103. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 1364 EP 1364 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23801365 ER PT J AU Patrinos, ME Balaraman, V Meister, J Ku, T Stenzler, A Easa, D AF Patrinos, ME Balaraman, V Meister, J Ku, T Stenzler, A Easa, D TI The effect of asymmetric high frequency oscillation (AHFO) on the clearance of meconium from the lungs of the neonatal piglet. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,HONOLULU,HI. UNIV HAWAII,TRIPLER ARMY MED CTR,HONOLULU,HI 96822. SENSORMED CORP,YORBA LINDA,CA 92687. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 1407 EP 1407 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23801408 ER PT J AU Gelber, RP Iwamoto, LM Nakamura, KT AF Gelber, RP Iwamoto, LM Nakamura, KT TI Furosemide-induced desensitization to salbutamol in isolated neonatal guinea pig airways. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,DEPT MED,HONOLULU,HI 96822. UNIV HAWAII,TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 2300 EP 2300 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23802300 ER PT J AU Iwamoto, LM Christ, MJ Lavallee, SL Nakamura, KT AF Iwamoto, LM Christ, MJ Lavallee, SL Nakamura, KT TI Effect of amiloride on airway tone. SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,DEPT PEDIAT,HONOLULU,HI 96822. UNIV HAWAII,TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1996 VL 39 IS 4 BP 2306 EP 2306 PN 2 PG 1 WC Pediatrics SC Pediatrics GA UD238 UT WOS:A1996UD23802306 ER PT J AU Tocci, MD Scalora, M Bloemer, MJ Dowling, JP Bowden, CM AF Tocci, MD Scalora, M Bloemer, MJ Dowling, JP Bowden, CM TI Measurement of spontaneous-emission enhancement near the one-dimensional photonic band edge of semiconductor heterostructures SO PHYSICAL REVIEW A LA English DT Article ID DEVICE APPLICATIONS; QUANTUM OPTICS; MICROCAVITIES; ATOM; GAAS; CAVITY; MEDIA; LASER AB We present results of an experimental investigation into alteration of the spontaneous emission spectrum of GaAs from within one-dimensional photonic band gap (PEG) structures. The PEG samples are multilayer AlAs/Al0.2Ga0.8As/GaAs p-i-n light-emitting diodes, with layers arranged as a distributed Bragg reflector. The emission spectra normal to the layers are measured, and we use a simple method to model the power spectrum of spontaneous emission from within the structures. We find that the emitted power is enhanced by a factor of 3.5 at the frequencies near the photonic band edge. C1 UNIV ALABAMA,DEPT ELECT ENGN,HUNTSVILLE,AL 35899. USA,MISSILE COMMAND,AMSMI RD WS,REDSTONE ARSENAL,AL 35898. RP Tocci, MD (reprint author), UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 35 TC 126 Z9 126 U1 0 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD APR PY 1996 VL 53 IS 4 BP 2799 EP 2803 DI 10.1103/PhysRevA.53.2799 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA UE921 UT WOS:A1996UE92100111 ER PT J AU Lang, P Nordstrom, L Wildberger, K Zeller, R Dederichs, PH Hoshino, T AF Lang, P Nordstrom, L Wildberger, K Zeller, R Dederichs, PH Hoshino, T TI Ab initio calculations of interaction energies of magnetic layers in noble metals: Co/Cu(100) SO PHYSICAL REVIEW B LA English DT Article ID BRILLOUIN-ZONE INTEGRATIONS; SPECIAL POINTS; EXCHANGE; CU; MULTILAYERS; IMPURITIES; FE; OSCILLATIONS; SANDWICHES AB We present ab initio calculations for the interlayer exchange coupling of magnetic Co(100) layers in Cu. The calculations are based on a Korringa-Kohn-Rostoker Green's function method for planar defects and apply the frozen potential approximation, allowing a direct calculation of the interaction via single-particle energies. Thus the subtraction of large total energies is avoided and efficient calculations for large layer thicknesses are enabled. By dividing the two-dimensional Brillouin zone into areas around different stationary points q(i), an analysis of the asymptotic behavior is given. The different dependences of the short and long oscillation periods on the thickness of the magnetic layers are explained by the q(parallel to)- and symmetry-projected density of states of the Co layers. The effects of roughness on the interlayer coupling are simulated, leading to a strong reduction of the amplitudes and a suppression of the short-wavelength period. Our calculations are in good agreement with experiments and give a consistent picture of interlayer coupling in Co/Cu(100), as far as both the dependence on the thickness of the magnetic layers as well as the dependence on roughness are concerned. C1 SHIZUOKA UNIV, COLL ENGN, HAMAMATSU, SHIZUOKA 432, JAPAN. USA, RES LAB, COMPLEX SYST THEORY BRANCH, WASHINGTON, DC 20310 USA. GEORGE MASON UNIV, INST COMP & INFORMAT SCI, FAIRFAX, VA 22030 USA. RP FORSCHUNGSZENTRUM JULICH, INST FESTKORPERFORSCH, POSTFACH 1913, D-52425 JULICH, GERMANY. RI Zeller, Rudolf/K-7094-2013 OI Zeller, Rudolf/0000-0002-9462-2649 NR 42 TC 48 Z9 48 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD APR 1 PY 1996 VL 53 IS 14 BP 9092 EP 9107 DI 10.1103/PhysRevB.53.9092 PG 16 WC Physics, Condensed Matter SC Physics GA UF064 UT WOS:A1996UF06400045 ER PT J AU Bendickson, JM Dowling, JP Scalora, M AF Bendickson, JM Dowling, JP Scalora, M TI Analytic expressions for the electromagnetic mode density in finite, one-dimensional, photonic band-gap structures SO PHYSICAL REVIEW E LA English DT Article ID NONLINEAR PERIODIC STRUCTURES; SPONTANEOUS EMISSION; RATES; MEDIA AB We derive an exact expression for the electromagnetic mode density, and hence the group velocity, for a finite, N-period, one-dimensional, photonic band-gap structure. We begin by deriving a general formula for the mode density in terms of the complex transmission coefficient of an arbitrary index profile. Then we develop a specific formula that gives the N-period mode density in terms of the complex transmission coefficient of the unit cell. The special cases of mode-density enhancement and suppression at the photonic band edge and also at midgap, respectively, are derived. The specific example of a quarter-wave stack is analyzed, and applications to three-dimensional structures, spontaneous emission control, delay lines, band-edge lasers, and superluminal tunneling times are discussed. C1 UNIV ALABAMA,DEPT ELECT ENGN,HUNTSVILLE,AL 35899. RP Bendickson, JM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 42 TC 439 Z9 455 U1 5 U2 26 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1063-651X J9 PHYS REV E JI Phys. Rev. E PD APR PY 1996 VL 53 IS 4 BP 4107 EP 4121 DI 10.1103/PhysRevE.53.4107 PN B PG 15 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA UH482 UT WOS:A1996UH48200055 ER PT J AU Dowling, JP AF Dowling, JP TI More spirited debate on physics, parapsychology and paradigms - Reply SO PHYSICS TODAY LA English DT Letter RP Dowling, JP (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD APR PY 1996 VL 49 IS 4 BP 81 EP 81 PG 1 WC Physics, Multidisciplinary SC Physics GA UD726 UT WOS:A1996UD72600019 ER PT J AU ShukittHale, B Stillman, MJ Lieberman, HR AF ShukittHale, B Stillman, MJ Lieberman, HR TI Tyrosine administration prevents hypoxia-induced decrements in learning and memory SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE hypobaric hypoxia; altitude exposure; precursor; reference memory; working memory; Morris water maze; spatial memory ID STRESS AB Exposure to hypobaric hypoxia rapidly produces decrements in learning and memory. Tyrosine, a neurotransmitter precursor, has beneficial behavioral effects when administered to animals and humans exposed to various acute stressors. To determine whether tyrosine would protect rats from the adverse effects of hypobaric hypoxia on spatial reference and working memory, it was administered to 27 male Fischer 344 rats tested in the Morris water maze, Rats were tested starting at 2 and 6 h of an 8 h exposure to a simulated altitude of 5950 m (19,500 ft) or sea level. Tyrosine or placebo was administered 1/2 h prior to each testing session (400 mg/kg, IP). Altitude exposure significantly increased working memory escape latency; treatment with tyrosine reversed this decrement. There was no effect of altitude or tyrosine on reference memory. There were also no treatment-related differences in performance when animals were tested the next day at sea level, The beneficial effects of tyrosine on working memory performance may be due to a direct effect of tyrosine on memory, alleviation of a hypoxia-induced retardation of learning, or to other central or peripheral effects of this dietary catecholamine precursor. C1 GEOCENTERS INC,NEWTON,MA 02159. USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV,NATICK,MA 01760. NR 25 TC 23 Z9 24 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD APR-MAY PY 1996 VL 59 IS 4-5 BP 867 EP 871 DI 10.1016/0031-9384(95)02107-8 PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA UC955 UT WOS:A1996UC95500042 PM 8778879 ER PT J AU Manning, LR Jenkins, WT Hess, JR Vandegriff, K Winslow, RM Manning, JM AF Manning, LR Jenkins, WT Hess, JR Vandegriff, K Winslow, RM Manning, JM TI Subunit dissociations in natural and recombinant hemoglobins SO PROTEIN SCIENCE LA English DT Article DE gel filtration; recombinant hemoglobin; subunit dissociation ID FUNCTIONAL-PROPERTIES; ALPHA-CHAINS; COOPERATIVITY; EQUILIBRIUM; OXYGEN; YEAST AB A precise and rapid procedure employing gel filtration on Superose-12 to measure the tetramer-dimer dissociation constants of some natural and recombinant hemoglobins in the oxy conformation is described. Natural sickle hemoglobin was chosen to verify the validity of the results by comparing the values with those reported using an independent method not based on gel filtration. Recombinant sickle hemoglobin, as well as a sickle double mutant with a substitution at the Val-6(beta) receptor site, had approximately the same dissociation constant as natural sickle hemoglobin. Of the two recombinant hemoglobins with amino acid replacements in the alpha 1 beta 2 subunit interface, one was found to be extensively dissociated and the other completely dissociated. In addition, the absence of an effect of the allosteric regulators DPG and IHP on the dissociation constant was demonstrated. Thus, a tetramer dissociation constant can now be determined readily and used together with other criteria for characterization of hemoglobins and their interaction with small regulatory molecules. C1 NORTHEASTERN UNIV,DEPT BIOL,BOSTON,MA 02115. ROCKEFELLER UNIV,NEW YORK,NY 10021. INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN. WALTER REED ARMY INST RES,WASHINGTON,DC. UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92103. FU NHLBI NIH HHS [HL-18819, HL-48018] NR 33 TC 65 Z9 65 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0961-8368 J9 PROTEIN SCI JI Protein Sci. PD APR PY 1996 VL 5 IS 4 BP 775 EP 781 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA UD304 UT WOS:A1996UD30400023 PM 8845768 ER PT J AU Iliopoulos, AG Tsokos, GC AF Iliopoulos, AG Tsokos, GC TI Immunopathogenesis and spectrum of infections in systemic lupus erythematosus SO SEMINARS IN ARTHRITIS AND RHEUMATISM LA English DT Review DE systemic lupus erythematosus; infection; immune defense ID PNEUMOCYSTIS-CARINII PNEUMONIA; IMMUNODEFICIENCY-VIRUS HIV; CONNECTIVE-TISSUE DISEASES; C-REACTIVE PROTEIN; T-CELL; INTRAVENOUS CYCLOPHOSPHAMIDE; IMMUNOSUPPRESSIVE THERAPY; SALMONELLA BACTEREMIA; HOSPITALIZED-PATIENTS; RHEUMATOID-ARTHRITIS AB Objective: This study reviews the pertinent immunopathologic mechanisms that contribute to increased susceptibility to infection in patients with systemic lupus erythematosus (SLE) and the spectrum of infections in patients with SLE. It assesses the impact on patient care, morbidity, and mortality. Methods: The authors performed an extensive search of the literature through MEDLINE, using appropriate keywords and manual search of bibliography cited by retrieved papers. Results: Infection is a leading cause of morbidity and mortality in SLE and may change the natural course of the disease. Patients with SLE display numerous cellular and humoral abnormalities that are expressed in a heterogeneous pattern and contribute in varying degrees to susceptibility to infectious agents. The use of corticosteroid and immunosuppressive drugs is only partially responsible for the high infection rate in lupus patients, Common as well as opportunistic pathogens are frequently encountered among patients with SLE. The susceptibility that SLE patients exhibit to certain bacteria is now better recognized, and a broadening spectrum of pathogens is being reported. The immunization of patients against influenza and pneumococcus and the administration of prophylactic therapy against Pneumocystis carinii infection in certain patients have recently been proposed. Conclusion: Disease activity and treatment are responsible for the extensive defects of the immune defense system in lupus patients that increase their susceptibility to an extensive range of infections. Infection imposes a serious burden on lupus patients and on the caring physician. (C) 1996 by W.B. Saunders Company C1 WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 186 TC 106 Z9 113 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0049-0172 J9 SEMIN ARTHRITIS RHEU JI Semin. Arthritis Rheum. PD APR PY 1996 VL 25 IS 5 BP 318 EP 336 DI 10.1016/S0049-0172(96)80018-7 PG 19 WC Rheumatology SC Rheumatology GA UE927 UT WOS:A1996UE92700004 PM 8778988 ER PT J AU Ho, HS Sondeen, JL Dubick, MA Wade, CE Gunther, RA AF Ho, HS Sondeen, JL Dubick, MA Wade, CE Gunther, RA TI The renal effects of 7.5% NaCl-6% dextran-70 versus lactated Ringer's resuscitation of hemorrhage in dehydrated sheep SO SHOCK LA English DT Article ID HYPERTONIC SALINE; 6-PERCENT DEXTRAN-70; MULTICENTER TRIAL; CONSCIOUS SWINE; SHOCK; NACL; HYPOTENSION; INFUSION; FAILURE; PLASMA AB A small volume of 7.5% NaCl/6% Dextran-70 (HSD) can rapidly expand the plasma volume, but concerns exist regarding its adverse effects on renal function in the dehydrated state, Sheep were thirsted for 4 days (13% plasma volume contraction), and subjected to a fixed-pressure shock model (mean arterial pressure of 50 mmHg for 2 h), followed by resuscitation with either HSD (4 mUkg) or lactated Ringer's solution (LR; 37 mL/kg). Mean arterial pressure was restored to 90%, cardiac output to 125% and 120%, and plasma volume to 78% and 72% of baseline in LR and HSD groups, respectively. Glomerular filtration rate improved to 100% of baseline following HSD compared with 82% following LR, No significant urinary 70,000 molecular weight dextran was observed, suggesting an intact renal glomerular membrane. These data suggest that small volume HSD resuscitation is effective, even with pre-existing dehydration. In addition, renal function is not compromised by HSD resuscitation of hemorrhaged, dehydrated animals. C1 USA,INST SURG RES,MED TRAUMA BRANCH,FT SAM HOUSTON,TX 78234. NASA,AMES RES CTR,DIV LIFE SCI,MOFFETT FIELD,CA 94035. RP Ho, HS (reprint author), UNIV CALIF DAVIS,MED CTR,SCH MED,DEPT SURG,SACRAMENTO,CA 95817, USA. NR 35 TC 9 Z9 9 U1 0 U2 0 PU BIOMEDICAL PRESS PI AUGUSTA PA 1021 15TH ST, BIOTECH PARK STE 9, AUGUSTA, GA 30901 SN 1073-2322 J9 SHOCK JI Shock PD APR PY 1996 VL 5 IS 4 BP 289 EP 297 DI 10.1097/00024382-199604000-00010 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA UE254 UT WOS:A1996UE25400010 PM 8721390 ER PT J AU Sniezek, JC Johnson, RE Ramirez, SG Hayes, DK AF Sniezek, JC Johnson, RE Ramirez, SG Hayes, DK TI Laryngoceles and saccular cysts SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID LARYNX AB Laryngoceles and saccular cysts are related, benign abnormalities of the larynx. The pathophysiology of both lesions can involve congenital as well as acquired factors, and the appearance of both may range from incidental findings on laryngoscopy to symptoms such as hoarseness, dysphagia, dyspnea, and laryngeal discomfort. The surgical techniques used for treatment of laryngoceles and saccular cysts are controversial. We present two cases for comparison and discuss the history, diagnosis, and surgical treatment of laryngoceles and saccular cysts. Emphasis is on the surgical approach, which in both cases transected the thyrohyoid membrane externally and provided excellent visualization and exposure without significant morbidity. RP Sniezek, JC (reprint author), BROOKE ARMY MED CTR,DEPT SURG,DIV OTOLARYNGOL HEAD & NECK SURG,SAN ANTONIO,TX 78234, USA. NR 11 TC 9 Z9 9 U1 0 U2 1 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD APR PY 1996 VL 89 IS 4 BP 427 EP 430 DI 10.1097/00007611-199604000-00017 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA UE255 UT WOS:A1996UE25500017 PM 8614888 ER PT J AU Toedt, DMG Byrd, JC Omori, D AF Toedt, DMG Byrd, JC Omori, D TI Coxsackievirus-associated pancreatitis mimicking metastatic carcinoma SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID INFECTION AB The origin of idiopathic acute pancreatitis has not been well defined. Several enteroviruses, including coxsackievirus, have been implicated. We report the case of a 21-year-old woman with severe, acute pancreatitis with no classic risk factors. Initial evaluation failed to show choledocholithiasis. Her condition improved with conservative treatment, but symptoms recurred after resumption of oral intake. Computed tomography (CT) of the abdomen revealed an atypical pseudocyst and omental nodules suggestive of a metastatic malignancy An acute coxsackievirus B5 titer delayed CT-guided omental biopsy. The patient showed improvement, but progression of the omental nodules prompted open laparotomy. No malignant or inflammatory process was identified. This is the first reported case of presumed viral pancreatitis causing reactive omental nodules. This case shows a benign process mimicking malignancy, requiring an extensive, potentially dangerous workup. It also emphasizes the need to consider viral causes for unusual presentations of common problems. C1 WALTER REED ARMY MED CTR, INTERNAL MED SERV, HEMATOL ONCOL SERV, WASHINGTON, DC 20307 USA. RP Toedt, DMG (reprint author), WALTER REED ARMY MED CTR, DEPT MED, WASHINGTON, DC 20307 USA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD APR PY 1996 VL 89 IS 4 BP 441 EP 443 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA UE255 UT WOS:A1996UE25500021 ER PT J AU SMITH, TT AF SMITH, TT TI UNITED-STATES-ARMY COMBAT OPERATIONS IN THE INDIAN WARS OF TEXAS, 1849-1881 SO SOUTHWESTERN HISTORICAL QUARTERLY LA English DT Article RP SMITH, TT (reprint author), USA COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS, USA. NR 53 TC 1 Z9 1 U1 0 U2 0 PU TEXAS STATE HIST ASSN PI AUSTIN PA 2/306 RICHARDSON HALL UNIV STATION, AUSTIN, TX 78712 SN 0038-478X J9 SOUTHWEST HIST QUART JI Southw. Hist. Q. PD APR PY 1996 VL 99 IS 4 BP 500 EP 531 PG 32 WC History SC History GA UM627 UT WOS:A1996UM62700003 ER PT J AU OKeefe, MP Nedelkov, D Bieber, AL Nieman, RA AF OKeefe, MP Nedelkov, D Bieber, AL Nieman, RA TI Evidence for isomerization in myotoxin a from the prairie rattlesnake (Crotalus viridis viridis) SO TOXICON LA English DT Article ID CIS-TRANS-ISOMERASE; AMINO-ACID-SEQUENCE; SARCOPLASMIC-RETICULUM; SNAKE-VENOMS; CROTAMINE; SPECTROSCOPY; CYCLOPHILIN; ASSIGNMENT; RESOLUTION; BINDING AB Myotoxin a, from the venom of the prairie rattlesnake, Crotalus viridis viridis, exists asa temperature-dependent equilibrium of two interconverting forms. Reverse-phase high-performance liquid chromatography (RP-HPLC) shows that the two forms interconvert slowly enough at 25 degrees C to be seen as two separate peaks with a molar ratio of c. 1:4. Each peak can be isolated and individually injected to give the same two peaks in the same ratio of areas. The two peaks merge during chromatography at elevated temperatures, indicating an increase in the rate of interconversion. At low temperature, c. 5 degrees C, the individual peaks can be isolated and maintained for several days without reaching equilibrium. Mass analysis by matrix-assisted laser desorption ionization (MALDI) time-of-flight mass spectrometry shows that myotoxin a is present in both RP-HPLC peaks, suggesting that the two resolved forms are conformational isomers. Capillary zone electrophoresis (CZE) also shows two resolved, but interconvertible peaks over a range of pH values. Furthermore, RP-HPLC chromatograms of myotoxin a at concentrations from 0.013 mM to 0.41 mM maintain a consistent ratio of peak areas, without evidence of dimerization. Two-dimensional H-1-NMR nuclear Overhauser enhancement spectroscopy indicates the presence of a cis-proline peptide bond, consistent with an equilibrium mixture of cis-trans isomers; however, addition of peptidyl-prolyl cis-trans isomerase (PPI) does not enhance the rate of equilibration of the RP-HPLC peaks isolated at c. 5 degrees C. (C) 1996 Elsevier Science Ltd. C1 ARIZONA STATE UNIV,DEPT CHEM & BIOCHEM,TEMPE,AZ 85287. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. FU NIGMS NIH HHS [2RO1 GM34925] NR 44 TC 13 Z9 13 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1996 VL 34 IS 4 BP 417 EP 434 DI 10.1016/0041-0101(95)00154-9 PG 18 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA UJ846 UT WOS:A1996UJ84600005 PM 8735241 ER PT J AU Perry, ES Moore, RH Berger, TA Billups, LC Maybee, DA Salata, KF Lippert, LE AF Perry, ES Moore, RH Berger, TA Billups, LC Maybee, DA Salata, KF Lippert, LE TI In vitro and in vivo persistence of reticulocytes from donor red cells SO TRANSFUSION LA English DT Article ID FLOW CYTOMETRIC ANALYSIS; THIAZOLE ORANGE; SURVIVAL AB Background: Reticulocytes are important in the phenotyping of transfused patients, Reticulocytes can persist in blood units for the shelf life of the unit. Study Design and Methods: Temperature dependence of reticulocyte persistence was examined in vitro at 4, 24, and 37 degrees C by using thiazole orange staining and flow cytometric analysis. Two-color flow cytometric analysis was used to evaluate the persistence of donor reticulocytes in transfused patients. Results: Flow cytometric analysis using thiazole orange demonstrated that persistence of reticulocytes in units of stored CPDA-1 blood was temperature-dependent. Reticulocytes disappeared over 13 and 6 days at 24 degrees C and 37 degrees C, respectively, but at 4 degrees C the reticulocyte count changed little over 35 days. Two-color flow cytometric analysis of reticulocyte antigens was used to follow donor reticulocytes in 14 transfusion events in nine different patients. Donor reticulocytes persisted through 24 hours in 75 percent of the patients and were detectable at 48 hours in three patients. Conclusion: This study demonstrates that reticulocytes persist during refrigerated storage; they are detectable in the circulation of most recipients for the first 24 hours after transfusion and in the circulation of a few recipients after 48 hours. These findings may have relevance for separation techniques based on reticulocyte density in samples drawn shortly after transfusion and for evaluation of reticulocyte counts in patients with hematologic abnormalities. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PEDIAT HEMATOL ONCOL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,MED SERV LAB,WASHINGTON,DC 20307. NR 23 TC 19 Z9 19 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD APR PY 1996 VL 36 IS 4 BP 318 EP 321 DI 10.1046/j.1537-2995.1996.36496226144.x PG 4 WC Hematology SC Hematology GA UK637 UT WOS:A1996UK63700006 PM 8623131 ER PT J AU Narayan, P Trachtenberg, J Lepor, H Debruyne, FMJ Tewari, A Stone, N Das, S JimenezCruz, JF Shearer, R Klingbert, I Schellhammer, PF Costello, AJ ODonoghue, N Crawford, D Collste, L SchultzeSeemann Kirkemo, A Badelamant, R Wenderoth, UK Brawer, M Bouffioux, C McLeod, DG Flanigan, RC Gonick, P Breul, J Schick, E Kreigmair, M Kramer Frick, J Kaulen Bauer, H Jaske, G Heney, N AF Narayan, P Trachtenberg, J Lepor, H Debruyne, FMJ Tewari, A Stone, N Das, S JimenezCruz, JF Shearer, R Klingbert, I Schellhammer, PF Costello, AJ ODonoghue, N Crawford, D Collste, L SchultzeSeemann Kirkemo, A Badelamant, R Wenderoth, UK Brawer, M Bouffioux, C McLeod, DG Flanigan, RC Gonick, P Breul, J Schick, E Kreigmair, M Kramer Frick, J Kaulen Bauer, H Jaske, G Heney, N TI A dose-response study of the effect of flutamide on benign prostatic hyperplasia: Results of a multicenter study SO UROLOGY LA English DT Article ID NONSTEROIDAL ANTIANDROGEN; SCH 13521; HYPERTROPHY AB Objectives. The objective of this study was to evaluate efficacy, safety, and dose-response profiles of four dosing schemes of flutamide over 24 weeks. Methods. Patients were randomized to receive one of the following five treatment regimens for a period of 24 weeks: placebo capsule, flutamide capsules 125 mg twice daily, 250 mg once daily, 250 mg twice daily, and 250 mg three times daily. Patients were then evaluated at baseline (0 weeks) and at 4, 6, 12, 18, and 24 weeks after the start of treatment, and 8 weeks after the end of treatment (32 weeks). Evaluation of efficacy was performed by noting changes in urine flow rate, residual urine volume, symptom score, prostate volume, and prostate-specific antigen level. A total of 372 patients were enrolled into the study at 32 centers (14 centers in the United States and 18 international centers). Results. Baseline peak urinary flow rate and percent change from baseline in maximum flow rate showed a dose-related increase at 4 and 6 weeks; this increase was significant in the 250 mg three times daily group. At later time points, no significant differences between the flutamide and placebo groups were observed, largely because of the decreasing number of evaluable patients. At 4 and 6 weeks, 25% of patients in the 250 mg three times daily group had more than 3 cc/s increase in uroflow compared to about 10% of placebo patients (P < 0.05). All flutamide-treated groups had a significant decrease in prostate volume from baseline to the last treatment visit compared to placebo and this reduction was dose related (in comparison to placebo: P < 0.05 for 125 mg twice daily and P < 0.001 for all other treatment arms). Median decrease for the flutamide-treated groups ranged from 6% to 25% at 12 weeks and from 14% to 29% at 24 weeks. All treatment groups showed a subsequent increase in prostate volume after treatment was stopped. Furthermore, there was a significant reduction in residual urine volume at 24 weeks only in the 250 mg three times daily group. It increased following cessation of therapy. Urinary symptoms at 6, 12, 18, and 24 weeks did not show any significant difference between placebo and any flutamide dose group. The most common adverse events were nipple and breast tenderness (42% to 52%), diarrhea (29% to 34%), and gynecomastia (14% to 19%). Each of these adverse events had a significantly higher incidence in all flutamide dose groups compared with placebo, but none appeared to occur in a dose-related fashion. Sixteen percent of patients in the placebo group and 25% to 39% of patients in flutamide groups were discontinued due to diarrhea (12% to 17%) or nipple and breast tenderness (4% to 8%). A total of 1% to 3% of patients in various treatment arms discontinued due to deranged liver enzymes (1% for placebo); and 1% to 4% due to impotence (1% for placebo). Conclusions. Flutamide reduced the prostate volume in a dose-related fashion and resulted in an increase in peak flow rate at 4 weeks (3% for 250 mg three times daily, P value < 0.05), but the early positive effects did not maintain statistical significance due to an increasing number of dropouts due to adverse events. Effect on postvoid residual volume was observed only at the highest dose and at 24 weeks (median reduction, 25 mL, P < 0.05). Despite volume reduction and early improvement in peak flow rate, there were no significant differences in urinary symptoms among the placebo and flutamide groups. Higher incidences of diarrhea, breast tenderness, and gynecomastia, however, were the main limiting factors in this study and until these problems are overcome, the role of flutamide in the management of benign prostatic hyperplasia remains investigational. C1 UNIV FLORIDA,SCH MED,COLL MED,GAINESVILLE,FL 32610. UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143. DEPT VET AFFAIRS MED CTR,SAN FRANCISCO,CA. TORONTO GEN HOSP,TORONTO,ON,CANADA. MED COLL WISCONSIN,MILWAUKEE,WI 53226. ACAD HOSP RADBOND,NIJMEGEN,NETHERLANDS. MT SINAI HOSP,NEW YORK,NY 10029. KAISER PERMANENTE MED CORP HOSP,WALNUT CREEK,CA. HOSP LA FE,E-46009 VALENCIA,SPAIN. UNIV LONDON ST GEORGES HOSP,LONDON,ENGLAND. UROL CTR FLORIDA,OCALA,FL. SENTARA CANC INST,NORFOLK,VA. ST VINCENTS HOSP,MELBOURNE,VIC,AUSTRALIA. ST PETERS HOSP,LONDON WC2A 2EX,ENGLAND. UNIV COLORADO,DENVER,CO 80202. HUDDINGE HOSP,S-14186 HUDDINGE,SWEDEN. UNIV KLINIKUM FREIBURG,FREIBURG,GERMANY. HENRY FORD HOSP,DETROIT,MI 48202. OHIO STATE UNIV,COLUMBUS,OH 43210. UNIV KLIN,ULM,GERMANY. UNIV WASHINGTON,SEATTLE,WA 98195. CHU LIEGE,HOP BAVIERE,LIEGE,BELGIUM. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV MED SCH,MAYWOOD,IL. TECH UNIV MUNICH,UROL KLIN & POLIKLIN,W-8000 MUNICH,GERMANY. HOSP MAISONNEUVE ROSEMONT,MONTREAL,PQ,CANADA. UNIV FRANKFURT KLINIKUM,W-6000 FRANKFURT,GERMANY. ROLAND KLIN NIEDERSACHSENDAMM,BREMEN,GERMANY. RHEIN WESTFAL TH AACHEN,UROL CLIN,W-5100 AACHEN,GERMANY. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 20 TC 21 Z9 23 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD APR PY 1996 VL 47 IS 4 BP 497 EP 504 DI 10.1016/S0090-4295(99)80484-1 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA UM759 UT WOS:A1996UM75900011 PM 8638357 ER PT J AU Lassen, PM Mokulis, JA Kearse, WS Caballero, RL Quinones, D AF Lassen, PM Mokulis, JA Kearse, WS Caballero, RL Quinones, D TI Conservative management of rectocutaneous fistula following radical perineal prostatectomy SO UROLOGY LA English DT Article AB Inadvertent rectal injury during radical perineal prostatectomy may sometimes lead to the development of a rectocutaneous fistula. This has traditionally been managed with diverting colostomy until closure of the fistula is assured. We report 3 cases of rectocutaneous fistula following radical perineal prostatectomy, which were managed in a more conservative fashion. This included appropriate wound care, antibiotics, bower rest, parenteral hyperalimentation, and, in the presence of a concomitant urine leak in 1 case, optimal urinary diversion and bed rest. All fistulas healed without incident. C1 WOMACK ARMY MED CTR,DEPT UROL,FT BRAGG,NC. RP Lassen, PM (reprint author), WILFORD HALL USAF MED CTR,PSSU,DEPT UROL,2200 BERGQUIST DR,SUITE 1,LACKLAND AFB,TX 78236, USA. NR 3 TC 5 Z9 5 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD APR PY 1996 VL 47 IS 4 BP 592 EP 594 DI 10.1016/S0090-4295(99)80503-2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA UM759 UT WOS:A1996UM75900031 PM 8638376 ER PT J AU KIESLING, EC AF KIESLING, EC TI IF-IT-AINT-BROKE-DONT-FIX-IT, FRENCH MILITARY DOCTRINE BETWEEN THE WORLD WARS SO WAR IN HISTORY LA English DT Article; Proceedings Paper CT 1994 Meeting of the Society-for-Military-History CY 1994 CL WASHINGTON, DC SP Soc Military Hist RP KIESLING, EC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 22 TC 1 Z9 1 U1 0 U2 0 PU EDWARD ARNOLD PUBL LTD PI LONDON PA 338 EUSTON ROAD, LONDON, ENGLAND NW1 3BH SN 0968-3445 J9 WAR HIST JI War Hist. PD APR PY 1996 VL 3 IS 2 BP 208 EP 223 DI 10.1177/096834459600300204 PG 16 WC History; International Relations SC History; International Relations GA UK834 UT WOS:A1996UK83400004 ER PT J AU White, KD AF White, KD TI A new ice jam database SO WATER RESOURCES BULLETIN LA English DT Article DE snow and ice hydrology; ice; ice jams; flooding; water; resource database AB Ice jam data are often difficult to locate, and doing so requires a search of many different data sources. The US Army Cold Regions Research and Engineering Laboratory (CRREL)has compiled an Ice Jam Database that provides information on nearly 9300 ice events in the United States. The information may be quantitative (e.g., event stage or discharge), qualitative (e.g., a narrative description), or a combination of both. References are provided to serve as a basis for further investigation. Although some selection bias may exist in the database because of its reliance on certain data sources, the database can be an asset in water resources planning and engineering. This paper is an overview of the CRREL Ice Jam Database and presents two applications of it. RP White, KD (reprint author), USA,COLD REG RES & ENGN LAB,ICE ENGN RES DIV,72 LYME RD,HANOVER,NH 03755, USA. NR 10 TC 3 Z9 3 U1 1 U2 1 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD APR PY 1996 VL 32 IS 2 BP 341 EP 348 PG 8 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA UG715 UT WOS:A1996UG71500013 ER PT J AU Ward, FA Roach, BA Henderson, JE AF Ward, FA Roach, BA Henderson, JE TI The economic value of water in recreation: Evidence from the California drought SO WATER RESOURCES RESEARCH LA English DT Article ID DEMAND AB A significant barrier to economically efficient management of most reservoir systems is lack of reliable information about how recreational values change with reservoir levels. This paper presents evidence on marginal values of water for recreation at Corps of Engineer reservoirs in the Sacramento, California, District. Data on visitors were collected by origin and destination before and during the early part of the 1985-1991 California drought. Because lake levels varied widely during the sample period, water's effect on visits was isolated from price and other effects. An estimated regional travel cost model containing water level as a visit predictor provided information to compute marginal values of water in recreation. For the range of the lake levels seen, annual recreational values per acre-foot (1234 m(3)) of water vary from $6 at Pine Flat Reservoir to more than $600 at Success Lake. These findings are limited to use values of visitors who travel to the reservoirs and do not reflect passive use values to people who value the reservoirs but never visit them. Analysts could apply similar methods to other river basins in which a public agency controls the management of multiple water uses. C1 UNIV CALIF DAVIS,DIV ENVIRONM STUDIES,DAVIS,CA 95616. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NEW MEXICO STATE UNIV,DEPT AGR ECON & AGR BUSINESS,LAS CRUCES,NM 88003. NR 18 TC 8 Z9 12 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD APR PY 1996 VL 32 IS 4 BP 1075 EP 1081 DI 10.1029/96WR00076 PG 7 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA UC939 UT WOS:A1996UC93900027 ER PT J AU Williamson, LC Halpern, JL Montecucco, C Brown, JE Neale, EA AF Williamson, LC Halpern, JL Montecucco, C Brown, JE Neale, EA TI Clostridial neurotoxins and substrate proteolysis in intact neurons - Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID SPINAL-CORD NEURONS; TETANUS-TOXIN; NEUROTRANSMITTER RELEASE; SYNAPTIC TRANSMISSION; MEMBRANE-PROTEIN; CULTURE; SNAP-25; FUSION; IDENTIFICATION; SYNAPTOBREVIN AB Clostridial neurotoxins are zinc endopeptidases that block neurotransmission and have been shown to cleave, in vitro, specific proteins involved in synaptic vesicle docking and/or fusion. We have used immunohistochemistry and immunoblotting to demonstrate alterations in toxin substrates in intact neurons under conditions of toxin-induced blockade of neurotransmitter release. Vesicle-associated membrane protein, which colocalizes with synaptophysin, is not detectable in tetanus toxin-blocked cultures. Syntaxin, also concentrated in synaptic sites, is cleaved by botulinum neurotoxin C. Similarly, the carboxyl terminus of the synaptosomal-associated protein of 25 kDa (SNAP-25) is not detectable in botulinum neurotoxin A-treated cultures. Unexpectedly, tetanus toxin exposure causes an increase in SNAP-25 immunofluorescence, reflecting increased accessibility of antibodies to antigenic sites rather than increased expression of the protein. Furthermore, botulinum neurotoxin C causes a marked loss of the carboxyl terminus of SNAP-25 when the toxin is added to living cultures, whereas it has no action on SNAP-25 in in vitro preparations, This study is the first to demonstrate in functioning neurons that the physiologic response to these toxins is correlated with the proteolysis of their respective substrates, Furthermore, the data demonstrate that botulinum neurotoxin C, in addition to cleaving syntaxin, exerts a secondary effect on SNAP-25. C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. UNIV PADUA,CTR CNR BIOMEMBRANE,I-35121 PADUA,ITALY. UNIV PADUA,DIPARTIMENTO SCI BIOMED SPERIMENTALI,I-35121 PADUA,ITALY. USA,INST INFECT DIS,FT DETRICK,MD 21701. RP Williamson, LC (reprint author), NICHHD,DEV NEUROBIOL LAB,NIH,BLDG 49,RM 5A38,BETHESDA,MD 20892, USA. FU Telethon [473] NR 43 TC 155 Z9 157 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 29 PY 1996 VL 271 IS 13 BP 7694 EP 7699 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA UC774 UT WOS:A1996UC77400076 PM 8631808 ER PT J AU Jones, DL Kroenke, K Landry, FJ Tomich, DJ Ferrel, RJ AF Jones, DL Kroenke, K Landry, FJ Tomich, DJ Ferrel, RJ TI Cost savings using a stepped-care prescribing protocol for nonsteroidal anti-inflammatory drugs SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; RISK; PHYSICIANS; IBUPROFEN; TOXICITY; THERAPY; ASPIRIN AB Objective.-To lower nonsteroidal anti-inflammatory drug (NSAID) costs while maintaining quality patient care and clinician satisfaction. Design.-Before and after 21-month trial with one study site and two control sites and a questionnaire that was sent to 203 clinicians. Setting and Subjects.-Two military medical centers and two affiliated primary care clinics. All beneficiaries filling outpatient NSAID prescriptions. Interventions.-An NSAID prescribing protocol was implemented requiring a trial of either ibuprofen or indomethacin before new prescription of more expensive NSAIDs. One control center used an NSAID computer cost-prompt and the other had no intervention. Main Outcome Measures.-The proportion of expensive NSAIDs prescribed at each institution and total NSAID costs adjusted for prescription volume. Clinician acceptance and patient impact were assessed by the questionnaire. Results.-Study site clinicians (n=158) reported very few protocol-related patient care problems. A minority (9%) of study site clinicians considered the protocol very bothersome, and only 2% felt it should be discontinued. Quarterly use of expensive NSAIDs at the study site fell from 34% to 21%, decreasing costs by 30% (P<.001). In contrast, the site with a computer cost-prompt had only a 5% decrease in NSAID costs, while costs at the site with no intervention increased 2%. Conclusions.-For drugs with similar benefits and adverse effects, a ''stepped formulary'' approach requiring an initial trial of one of the less expensive agents can maintain physician prescribing choices and satisfaction while lowering costs. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. MADIGAN ARMY MED CTR,DEPT PHARM,TACOMA,WA 98431. RP Jones, DL (reprint author), WALTER REED ARMY MED CTR,INTERNAL MED SERV,6800 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 32 TC 18 Z9 18 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 27 PY 1996 VL 275 IS 12 BP 926 EP 930 DI 10.1001/jama.275.12.926 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA UA563 UT WOS:A1996UA56300032 PM 8598620 ER PT J AU Roth, D Zucker, K Cirocco, R Burke, G Ciancio, G Esquenazi, V Swanson, SJ Miller, J AF Roth, D Zucker, K Cirocco, R Burke, G Ciancio, G Esquenazi, V Swanson, SJ Miller, J TI A prospective study of hepatitis C virus infection in renal allograft recipients SO TRANSPLANTATION LA English DT Article ID NON-B-HEPATITIS; KIDNEY-TRANSPLANT RECIPIENTS; NON-A-HEPATITIS; LIVER-DISEASE; 2ND DECADE; ANTIBODY; TRANSFUSION; MORTALITY; ASSAY AB Hepatitis C virus (HCV) is the predominant cause of posttransplant non-A, non-B hepatitis among renal allograft recipients. Prior studies evaluating the impact of HCV in kidney transplantation have been retrospective in design and based largely on changes in serum transaminases. We studied a group of HCV-infected end-stage renal disease patients prospectively with pretransplant liver biopsies and close virologic and biochemical follow-up posttransplant. Fourteen patients have been followed a mean of 11.6+/-5.6 months posttransplant (range, 5-21 months), Six had changes of chronic hepatitis on pretransplant liver biopsy while 8 showed only mild histologic abnormalities. Circulating viral titers increased several-fold over baseline levels during posttransplant follow-up. Viral replication was particularly enhanced immediately following a course of antilymphocyte therapy. Although all patients showed a 2-3-fold increase in alanine aminotransferase (ALT) following transplantation, there were no associations noted between pretransplant liver histology, the use of FK506 and/or cyclosporine-based immunosuppression, and the magnitude of ALT change posttransplant. The only clinical outcome found to differ significantly was a higher incidence of cytomegalovirus infection among patients with chronic hepatitis. All patients are alive with functioning grafts. There have been no episodes of fulminant or subfulminant liver failure, We conclude that HCV-infected patients can be safely transplanted with excellent short-term follow-up. Continued monitoring with sequential liver biopsies will be needed to define the long-term course of HCV infection in an immunosuppressed population. C1 UNIV MIAMI,SCH MED,DEPT SURG,MIAMI,FL 33101. UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33101. VET ADM MED CTR,MIAMI,FL 33101. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. RP Roth, D (reprint author), UNIV MIAMI,SCH MED,DEPT MED,DIV NEPHROL R 126,POB 016960,MIAMI,FL 33101, USA. FU NIDDK NIH HHS [R01 DK 25243-10] NR 27 TC 85 Z9 85 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD MAR 27 PY 1996 VL 61 IS 6 BP 886 EP 889 DI 10.1097/00007890-199603270-00007 PG 4 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA UD973 UT WOS:A1996UD97300007 PM 8623154 ER PT J AU Helbig, HF Beasock, JV Ramseyer, GO Walsh, LH AF Helbig, HF Beasock, JV Ramseyer, GO Walsh, LH TI Microcrystallography using atomic force microscopy SO APPLIED PHYSICS LETTERS LA English DT Article AB Scanning microscopy can be used to obtain crystallographic information about suboptical structures. By the same token, the x-y-z length scales of scanning microscopy can be brought into mutual consistency by measuring the angles between facets of crystallites of known habit. (C) 1996 American Institute of Physics. RP Helbig, HF (reprint author), ERDC,ROME LAB,525 BROOKS RD,ROME,NY 13441, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 25 PY 1996 VL 68 IS 13 BP 1778 EP 1780 DI 10.1063/1.116664 PG 3 WC Physics, Applied SC Physics GA UB535 UT WOS:A1996UB53500012 ER PT J AU Mello, KE Soss, SR Murarka, SP Lu, TM Lee, SL AF Mello, KE Soss, SR Murarka, SP Lu, TM Lee, SL TI Low-temperature epitaxial growth of CoGe2(001)/GaAs(100) films using the partially ionized beam deposition technique SO APPLIED PHYSICS LETTERS LA English DT Article ID N-TYPE GAAS; OHMIC CONTACTS AB The partially ionized beam (PIE) deposition technique was used to deposit CoGe2(001) thin films heteroepitaxially on GaAs(100) substrates. The epitaxial arrangement is CoGe2(001)/GaAs(100). It is found that the best epitaxy was obtained with an ion energy around 1100 eV and with a substrate temperature of 280 degrees C. The wafers were treated only by immersion in HF:H2O 1:10 immediately prior to deposition. Contacts grown at the optimal epitaxial formation conditions displayed Ohmic behavior, while contacts grown at higher or lower substrate temperatures had rectifying behavior. Epitaxial formation of CoGe2, a high melting point, low resistivity cobalt germanide phase, offers the possibility of forming a stable contact to n-GaAs. (C) 1996 American Institute of Physics. C1 USA,ARMAMENT RES DEV & ENGN CTR,WATERVLIET,NY 12189. RENSSELAER POLYTECH INST,DEPT MAT SCI & ENGN,TROY,NY 12180. RENSSELAER POLYTECH INST,DEPT PHYS APPL PHYS & ASTRON,TROY,NY 12180. RP Mello, KE (reprint author), RENSSELAER POLYTECH INST,CTR INTEGRATED ELECTR & ELECTR MFG,TROY,NY 12180, USA. NR 21 TC 4 Z9 4 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 25 PY 1996 VL 68 IS 13 BP 1817 EP 1819 DI 10.1063/1.116023 PG 3 WC Physics, Applied SC Physics GA UB535 UT WOS:A1996UB53500025 ER PT J AU Stroscio, MA Sirenko, YM Yu, S Kim, KW AF Stroscio, MA Sirenko, YM Yu, S Kim, KW TI Acoustic phonon quantization in buried waveguides and resonators SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID SEMICONDUCTOR SUPERLATTICES; ELECTRON-GAS; MODES; TRANSMISSION; HETEROSTRUCTURES; LOCALIZATION; CARRIERS; WIRES AB Starting from a classical Hamiltonian for nonhomogeneous elastic media, a procedure is developed for acoustic phonon quantization in resonators as well as linear and planar waveguides. The formalism is illustrated in an example of acoustic phonon modes in a buried cylindrical waveguide. The deformation potential Hamiltonian for electron-acoustic phonon interaction is also obtained. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. RP Stroscio, MA (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC 27709, USA. NR 37 TC 22 Z9 22 U1 0 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD MAR 25 PY 1996 VL 8 IS 13 BP 2143 EP 2151 DI 10.1088/0953-8984/8/13/006 PG 9 WC Physics, Condensed Matter SC Physics GA UD884 UT WOS:A1996UD88400006 ER PT J AU Ayyagari, M Akkara, JA Kaplan, DL AF Ayyagari, M Akkara, JA Kaplan, DL TI Molecular weight control in enzymatic polymerization of phenols in nonaqueous media SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 4 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501659 ER PT J AU Henderson, LA Svirkin, YY Gross, RA Kaplan, DL Swift, G AF Henderson, LA Svirkin, YY Gross, RA Kaplan, DL Swift, G TI Enzyme catalyzed polymerizations of epsilon-caprolactone: Effects of initiator on propagation kinetics and mechanism SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. ROHM & HAAS CO,SPRING HOUSE,PA 19477. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 5 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501660 ER PT J AU Linden, CL Pearce, FJ Wiesmann, WP Shalaby, SW AF Linden, CL Pearce, FJ Wiesmann, WP Shalaby, SW TI Complaint absorbable tissue adhesives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 CLEMSON UNIV,DEPT BIOENGN,CLEMSON,SC 29634. WALTER REED ARMY INST RES,DEPT SURG,WASHINGTON,DC 20307. POLY MED INC,ANDERSON,SC 29625. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 18 EP BTEC PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501954 ER PT J AU Taub, IA AF Taub, IA TI Generic approvals of irradiated foods: Application of the chemiclearance principle. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,SOLDIER SYST COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 19 EP AGFD PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48200017 ER PT J AU Taub, IA Kim, HJ Yang, TCS Prakash, A Barringer, S AF Taub, IA Kim, HJ Yang, TCS Prakash, A Barringer, S TI Microwave and ohmically sterilized foods: Validation with intrinsic chemical markers. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. OHIO STATE UNIV,COLUMBUS,OH 43210. CHAPMAN UNIV,ORANGE,CA 92668. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 20 EP AGFD PN 1 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48200018 ER PT J AU Xu, X Banerjee, S Baumgartner, T Premchandran, R Kommareddi, N McCormick, M John, V McPherson, CJ OConnor, CJ Akkara, J Kaplan, D AF Xu, X Banerjee, S Baumgartner, T Premchandran, R Kommareddi, N McCormick, M John, V McPherson, CJ OConnor, CJ Akkara, J Kaplan, D TI A biocatalytic approach to polymer-protein and polymer-nanoparticle composites SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SYST COMMAND,NATICK,MA 01748. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 22 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501677 ER PT J AU Akkara, JA Kaplan, DL Kurioka, H Uyama, H Kobayashi, S AF Akkara, JA Kaplan, DL Kurioka, H Uyama, H Kobayashi, S TI Characterization of polyaniline synthesized by horseradish peroxidase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. TOHOKU UNIV,DEPT MOLEC CHEM & ENGN,SENDAI,MIYAGI 980,JAPAN. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 23 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501678 ER PT J AU Famini, GR Lowrey, AH Wilson, LY AF Famini, GR Lowrey, AH Wilson, LY TI Using molecular orbital based parameters to predict properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 24 EP COMP PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202215 ER PT J AU Lenz, DE Brimfield, AA Cook, L AF Lenz, DE Brimfield, AA Cook, L TI The development of immunoassays for detection of chemical warfare agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 27 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202388 ER PT J AU Gross, RA Xu, J Svirkin, YY Henderson, LA Bisht, KS Kaplan, DL Swift, G AF Gross, RA Xu, J Svirkin, YY Henderson, LA Bisht, KS Kaplan, DL Swift, G TI Enzymes in organic media as catalysts for polyester synthesis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,STRNC YM,NATICK,MA 01760. ROHM & HAAS CO,SPRING HOUSE,PA 19477. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 38 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501693 ER PT J AU Bruno, FF Akkara, JA Kaplan, DL Gross, R Swift, JS Dordick, JS AF Bruno, FF Akkara, JA Kaplan, DL Gross, R Swift, JS Dordick, JS TI Regioselective enzymatic transesterification polysaccharides in organic solvent. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV IOWA,DEPT CHEM & BIOCHEM ENGN,IOWA CITY,IA 52242. UNIV IOWA,CTR BIOCATALYSIS & BIOPROC,IOWA CITY,IA 52242. UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA. ROHM & HASS CO,SPRING HOUSE,PA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 40 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501695 ER PT J AU Price, CB Thibodeaux, LJ Reible, DD Brannon, JM Myers, TE AF Price, CB Thibodeaux, LJ Reible, DD Brannon, JM Myers, TE TI Volatile organics emissions from contaminated sediments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LOUISIANA STATE UNIV,DEPT CHEM ENGN,BATON ROUGE,LA 70803. USA,WATERWAYS EXPT STN,ENVIRONM RES LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 44 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202405 ER PT J AU Gorte, RJ AF Gorte, RJ TI Methods for the characterization of acid sites in FCC catalysts. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV PENN,DEPT CHEM ENGN,PHILADELPHIA,PA 19104. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 48 EP PETR PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500891 ER PT J AU John, VT Banerjee, S Xu, XD Kommareddi, N Tata, M McPherson, G AF John, VT Banerjee, S Xu, XD Kommareddi, N Tata, M McPherson, G TI The templating of polymer morphology by surfactant-polymer interactions. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,NEW ORLEANS,LA 70118. USA,SOLDIER SYST COMMAND,NATICK,MA 01748. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 56 EP IEC PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202858 ER PT J AU Bhattacharjee, AK Karle, JM AF Bhattacharjee, AK Karle, JM TI Molecular electronic properties may predict antimalarial activity. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 57 EP COMP PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202248 ER PT J AU McLaren, SL Stedman, DH AF McLaren, SL Stedman, DH TI Detection of chemical agents by open path ftir spectroscopy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV DENVER,DENVER,CO 80208. USA,SFIL CME M,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 59 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202420 ER PT J AU Munavalli, S BashirHashemi, A Rohrbaugh, DK Rossman, DI Durst, HD AF Munavalli, S BashirHashemi, A Rohrbaugh, DK Rossman, DI Durst, HD TI Cubylcubanes from the coupling of cubyl radicals. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20744. USA,ARDEC,GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,ERDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 59 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500414 ER PT J AU Premchandran, R Banerjee, S John, VT McPHerson, GL AF Premchandran, R Banerjee, S John, VT McPHerson, GL TI The synthesis of fluorescent polymers in the microstructured environment of water-in-oil microemulsions. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SCI COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 62 EP POLY PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501289 ER PT J AU Banerjee, S Premchandran, R Baumgartner, T John, VT McPherson, GL AF Banerjee, S Premchandran, R Baumgartner, T John, VT McPherson, GL TI A biocatalytic approach towards synthesis of polymer CdS nanocomposites SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SCI COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 63 EP POLY PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501290 ER PT J AU Famini, GR Wilson, LY AF Famini, GR Wilson, LY TI Using semi-empirical molecular orbital methods in linear free energy relationships. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 123 EP COMP PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48202314 ER PT J AU Runner, BR McPherson, JC McPherson, JC AF Runner, BR McPherson, JC McPherson, JC TI The effect of a hyperlipemic agent, pluronic F-127(R), on red blood cell deformability during the development of the lipemic state. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 134 EP MEDI PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500133 ER PT J AU McPherson, JC Runner, RR McPherson, JC AF McPherson, JC Runner, RR McPherson, JC TI Erythrocyte sedimentation rate is increased in an experimental endogenous lipemia SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 135 EP MEDI PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500134 ER PT J AU Smith, TM Stroebel, GG McPherson, JC Chuang, AH McPherson, JC AF Smith, TM Stroebel, GG McPherson, JC Chuang, AH McPherson, JC TI Fluorophore labeled poloxamers protect red blood cells. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 AUGUSTA COLL,AUGUSTA,GA 30904. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 136 EP MEDI PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500135 ER PT J AU Pai, SV Chabalowski, CF Rice, BM AF Pai, SV Chabalowski, CF Rice, BM TI A comparative study of nonlocal density functional theory and ab initio methods: The potential energy surfaces of sym-triazine and cyanuric chloride reactions. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 167 EP PHYS PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48501096 ER PT J AU James, JE Riegner, DE AF James, JE Riegner, DE TI Performance evaluations of the mini chemical agent monitoring system (minicams) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 183 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201195 ER PT J AU Lin, AJ Zikry, AB Kyle, DE AF Lin, AJ Zikry, AB Kyle, DE TI Antimalarial activity of new dihydroartemisinin derivatives .7. 4-(p-substituted phenyl)-4-(R or S)[10-(alpha or beta)dihydroartemisininoxy]butyric acids. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 184 EP MEDI PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500183 ER PT J AU Warner, CH Labare, MP Wessel, TE AF Warner, CH Labare, MP Wessel, TE TI Synthesis and biodegradation of the VX nerve agent derivative 2-diiso-propylaminoethylsulfonic acid. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 202 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201214 ER PT J AU Carr, BM Riegner, DE AF Carr, BM Riegner, DE TI Novel instrumentation for the characterization biomolecules SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 305 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201316 ER PT J AU Munavalli, S Rohrbaugh, DK Rossman, DI Durst, HD AF Munavalli, S Rohrbaugh, DK Rossman, DI Durst, HD TI Reaction of 1,3-dithiane with trifluoromethylthiocopper SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,FT WASHINGTON,MD 20774. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 342 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500697 ER PT J AU Hsu, FL Bishop, JE Reeve, AM Szafraniec, LL Beaudry, WT AF Hsu, FL Bishop, JE Reeve, AM Szafraniec, LL Beaudry, WT TI Structural characterization of regioisomers: 3,4- and 4,3-anilino-hydroxypiperidines by NMR and chemical transformations SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 361 EP ORGN PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA UA485 UT WOS:A1996UA48500716 ER PT J AU DeVries, DJ Riegner, DE AF DeVries, DJ Riegner, DE TI Kinetic studies of gas-phase ion formation and dissociation SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 404 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201416 ER PT J AU Bunte, SW Jensen, GM Warshel, A Goodin, DB AF Bunte, SW Jensen, GM Warshel, A Goodin, DB TI Combined ab initio and electrostatic calculations of tryptophan-191 oxidation in compound ES of cytochrome C peroxidase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, RES LAB, AMSRL WT PC, ABERDEEN PROVING GROUND, MD 21005 USA. SCRIPPS RES INST, DEPT BIOL MOLEC, LA JOLLA, CA 92037 USA. UNIV SO CALIF, DEPT CHEM, LOS ANGELES, CA 90089 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 506 EP INOR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48203523 ER PT J AU Wynn, GH Cuadrado, JA Fountain, AW Allbee, DC AF Wynn, GH Cuadrado, JA Fountain, AW Allbee, DC TI Development and electrochemical characterizations of UV-laser induced conducting carbon networks on polyimides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. RI Wynn, Gary/B-3618-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 566 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201581 ER PT J AU Hall, JO AF Hall, JO TI Retraining for women chemists - One woman's experience. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MOBIL TECHNOL CTR BELVOIR,AMSTA,RBW,FT BELVOIR,VA 22060. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 24 PY 1996 VL 211 BP 643 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA UA482 UT WOS:A1996UA48201658 ER PT J AU Staecker, H Kopke, R Malgrange, B Lefebvre, P VandeWater, TR AF Staecker, H Kopke, R Malgrange, B Lefebvre, P VandeWater, TR TI NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells SO NEUROREPORT LA English DT Article DE auditory neurons; neurotrophins; otoxicity; trophic support; neuronal survival; growth factor therapy ID NEUROTROPHIC FACTOR; INNER-EAR AB DESTRUCTION of auditory hair cells results in a subsequent loss of auditory neurons. In situ hybridization and neuronal cell culture studies as well as analyses of the inner ears of neurotrophin and neurotrophin receptor gene knockout mice have shown that NT-3 and BDNF mediate both the development and survival of auditory neurons. In this study guinea pigs were exposed to the ototoxic combination of an aminoglycoside antibiotic and a loop diuretic and then received 8 weeks of intracochlear infusion of either NT-3, BDNF or NT-3+BDNF to determine whether site-specific application of these neurotrophins could prevent the loss of auditory neurons that follows a loss of auditory hair cells. Infusion of either NT-3 or NT-3 + BDNF into the scala tympani resulted in a > 90% survival of auditory neurons while BDNF infusion yielded a 78% survival rate, compared with a 14-24% neuronal survival rate in untreated ototoxin-exposed cochleae. These results show that loss of auditory neurons that occurs subsequent to a loss of auditory hair cells can be prevented by in vivo neurotrophin therapy with either NT-3 or BDNF. C1 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OTOLARYNGOL,BRONX,NY 10461. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461. UNIV LIEGE,DEPT HUMAN PHYSIOL & PATHOPHYSIOL,LIEGE,BELGIUM. USA,MED DEPT CTR & SCH,AMEDD STUDENT DETACHMENT,SAN ANTONIO,TX. OI Staecker, Hinrich/0000-0002-0348-3015; Malgrange, Brigitte/0000-0002-8957-2528 FU NIDCD NIH HHS [DC 00088] NR 24 TC 212 Z9 221 U1 0 U2 1 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD MAR 22 PY 1996 VL 7 IS 4 BP 889 EP 894 DI 10.1097/00001756-199603220-00011 PG 6 WC Neurosciences SC Neurosciences & Neurology GA UM765 UT WOS:A1996UM76500011 PM 8724667 ER PT J AU Anker, DS AF Anker, DS TI Optical parametric amplifiers: A discrete dynamical model of singly resonant operation leading to a novel approach to the design of systems for high-efficiency amplification SO APPLIED OPTICS LA English DT Article DE optical parametric oscillators; singly resonant oscillators; optical parametric oscillator-amplifiers; wavelength conversion; three-wave interactions; dynamical systems; discrete dynamical systems; nonlinear dynamics; chaotic dynamics ID BARIUM BORATE; OSCILLATOR AB A simple plane-wave model of pulsed, singly resonant, optical-parametric-oscillator and optical-parametric-oscillator-amplifier operation leads to a description of such systems in terms of a discrete dynamical system. The theoretical limits on conversion efficiencies derivable from this model were explored. Analysis of the model for an optical parametric oscillator-amplifier (OPOA) indicates that the effect that backconversion has in limiting efficiency can be avoided if one precisely shapes the time profile of the pump pulse and combines it with an OPOA that is Q switched. For a case of type I phase matching with beta-barium borate with a specific pump profile and a 65-mJ input pulse, under the assumption of small absorption, the following are demonstrated: (1) the theoretical possibility of amplification to a few joules at quantum efficiencies higher than 90% and (2) the possibility of amplification to approximately 1J at an energy efficiency near 45% in a configuration satisfying realistic stress constraints. Pulse widths are in the nanosecond range, and spot sizes are in the millimeter range. Issues of implementation are discussed. RP Anker, DS (reprint author), USA, RES LAB, AMSRL EP EJ, FT BELVOIR, VA 22060 USA. NR 19 TC 4 Z9 4 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 20 PY 1996 VL 35 IS 9 BP 1452 EP 1463 DI 10.1364/AO.35.001452 PG 12 WC Optics SC Optics GA UA966 UT WOS:A1996UA96600010 PM 21085258 ER PT J AU Chan, DS AF Chan, DS TI Computerized program for evaluating performance of a nutritional support team SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Letter RP Chan, DS (reprint author), TRIPLER ARMY MED CTR,DEPT PHARM,1 JARRETT WHITE RD,HONOLULU,HI 96859, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD MAR 15 PY 1996 VL 53 IS 6 BP 683 EP 684 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UA074 UT WOS:A1996UA07400015 PM 8800977 ER PT J AU Cole, MW Han, WY Pfeffer, RL Eckart, DW Ren, F Hobson, WS Lothian, JR Lopata, J Caballero, JA Pearton, SJ AF Cole, MW Han, WY Pfeffer, RL Eckart, DW Ren, F Hobson, WS Lothian, JR Lopata, J Caballero, JA Pearton, SJ TI A surface modification study of InGaP etched with an electron cyclotron resonance source at variable microwave powers SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RESIDUAL DAMAGE; INP; GAAS AB Etch-induced surface modifications, utilizing an electron cyclotron resonance source, have been studied as a function of controllable etch parameters. InGaP was etched with BCl3 at a constant substrate temperature (100 degrees C) and bias voltage (-145 V) using microwave powers varying between 250 and 1000 W. The surface morphology, residual etch damage, and surface stoichiometry were strongly influenced by changes in ion flux. The etch-induced lattice damage and surface smoothness increased as the ion energy was elevated. Low ion flux etching resulted in an In-enriched P-depleted surface suggesting nonuniform desorption of InClx which gave rise to the surface roughness observed at the low microwave powers. The smooth surfaces, achieved at the higher microwave power levels, were attributed to either efficient sputter-assisted desorption of the InClx etch products or to InClx desorption via plasma-induced surface heating. Results of this study demonstrate that etching at microwave powers between 500 and 750 W induce low residual damage and smooth surfaces while maintaining a reasonable etch rate for device processing. (C) 1996 American Institute of Physics. C1 AT&T BELL LABS,MURRAY HILL,NJ 07974. UNIV FLORIDA,GAINESVILLE,FL 32611. RP Cole, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 1996 VL 79 IS 6 BP 3286 EP 3289 DI 10.1063/1.361227 PG 4 WC Physics, Applied SC Physics GA TZ729 UT WOS:A1996TZ72900072 ER PT J AU Barth, J AF Barth, J TI The whiz rid of Wall Street's investment guide: How I returned 34 percent on my portfolio, and you can, too - Seto,M, Levingston,S SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 1996 VL 121 IS 5 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA TZ905 UT WOS:A1996TZ90500105 ER PT J AU Yourick, DL DeCoster, MA AF Yourick, DL DeCoster, MA TI Acute and chronic effects of estrogenic compounds on glutamate-stimulated phosphatidylinositol metabolism in primary neuronal cultures SO NEUROSCIENCE LETTERS LA English DT Article DE glutamate; inositol phosphates; estradiol; phenol red; primary neuronal cell cultures; phosphatidylinositol metabolism ID PHENOL RED; CELLS; NOREPINEPHRINE; SECRETION AB Glutamate (Glu)-stimulated phosphatidylinositol (PI) metabolism in primary neuronal cultures was found to be modulated by acute and chronic treatment with two estrogenic compounds. 17 beta-Estradiol 3-benzoate (0.1 and 1 mu M), when applied with Glu, significantly reduced Glu (40 mu M)-stimulated PI metabolism by 20-36%, an effect not seen with 17 alpha-estradiol. The weak estrogen phenol red (20 mu M), had no effect when added immediately before Glu stimulations. Two-week pretreatment with 17 beta-estradiol 3-benzoate (1 mu M) resulted in a significant decrease in Glu-stimulated PI metabolism (10-100 mu M). Chronic treatment with 20 mu M phenol red, at a concentration commonly found in culture medium, resulted in parallel but not statistically significant effects to those observed with chronic estradiol treatment. Estrogenic compounds may modulate the excitatory responses of neurons by both genomic and non-genomic means. C1 LOUISIANA STATE UNIV,MED CTR,CTR NEUROSCI,NEW ORLEANS,LA 70112. RP Yourick, DL (reprint author), WALTER REED ARMY MED CTR,RES INST,DIV NEUROPSYCHIAT,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. OI DeCoster, Mark/0000-0002-1716-2028 NR 25 TC 4 Z9 4 U1 1 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD MAR 15 PY 1996 VL 206 IS 2-3 BP 145 EP 148 DI 10.1016/S0304-3940(96)12459-9 PG 4 WC Neurosciences SC Neurosciences & Neurology GA UC069 UT WOS:A1996UC06900019 PM 8710172 ER PT J AU Sankaran, V Kim, KW Iafrate, GJ AF Sankaran, V Kim, KW Iafrate, GJ TI Tight-binding study of optical properties in short-period In0.53Ga0.47As/InP superlattices SO PHYSICAL REVIEW B LA English DT Article ID ELECTRONIC-STRUCTURE; GAAS/ALAS SUPERLATTICES; INTERBAND-TRANSITIONS; GAAS; SEMICONDUCTORS; IN1-XGAXASYP1-Y AB We present theoretical calculations of the imaginary part of the dielectric function, epsilon(2)(omega), of In0.53Ga0.47As/InP superlattices (SL's). An empirical tight-binding (TB) description of electronic states, including spin-orbit effects, is employed. We demonstrate that the absorption spectra of the constituent bulk materials can be reproduced very well with an appropriate choice of values for optical matrix elements between TB basis functions. These parameters then yield the absorption spectra of SL's. We have calculated epsilon(2)(omega) for ultrathin (In0.53Ga0.47As)(n)/(InP)(n) SL's with n=2 and 4. The computed epsilon(2) of SL's shows features similar to those found in the spectra of bulk constituents with some discernible effects due to confinement and SL periodicity. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Sankaran, V (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 23 TC 1 Z9 1 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD MAR 15 PY 1996 VL 53 IS 11 BP 6939 EP 6942 DI 10.1103/PhysRevB.53.6939 PG 4 WC Physics, Condensed Matter SC Physics GA UC740 UT WOS:A1996UC74000023 ER PT J AU Chen, CJ Choi, KK Tidrow, MZ Tsui, DC AF Chen, CJ Choi, KK Tidrow, MZ Tsui, DC TI Corrugated quantum well infrared photodetectors for normal incident light coupling SO APPLIED PHYSICS LETTERS LA English DT Article ID PERFORMANCE AB In this letter, we report a quantum well infrared photodetector geometry for normal incidence light coupling. The new optical coupling scheme utilizes total internal reflection at the sidewalls of triangular wires to create favorable optical polarization for infrared absorption. These wires are created by chemically etching an array of V grooves through the detector active region along a specific crystallographic direction. Experimental results from the initial single color as well as two-color detectors with linear wires and unthinned substrate show efficient light coupling comparable to the standard 45 degrees edge coupling, without the undesirable wavelength dependence or spectral narrowing effect of a conventional grating structure. At the same time, the dark current density is substantially reduced due to the partial material removal. Further improvement is expected by creating a two-dimensional coupling structure with substrate thinning. (C) 1996 American Institute of Physics. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Chen, CJ (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 72 Z9 73 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 11 PY 1996 VL 68 IS 11 BP 1446 EP 1448 DI 10.1063/1.116249 PG 3 WC Physics, Applied SC Physics GA TZ291 UT WOS:A1996TZ29100002 ER PT J AU Cites, JS Ashley, PR Leavitt, RP AF Cites, JS Ashley, PR Leavitt, RP TI Integration of nonlinear optical polymer waveguides with InGaAs p-i-n photodiodes SO APPLIED PHYSICS LETTERS LA English DT Article AB Performance requirements for systems employing optical guided wave components may be satisfied more easily through the hybrid integration of nonlinear optical (NLO) polymers and semiconductors. Reported in this letter, is the integration of NLO polymer waveguides with InGaAs p-i-n photodetectors at 1.3 mu m, with coupling efficiencies greater than 99% and system responsivities of 0.84 A/W. An analysis of the structure using a two-dimensional beam propagation model was performed. Planarization was maintained and the design allows for further integration of optoelectronic components. (C) 1996 American Institute of Physics. C1 USA,MISSILE COMMAND,CM,WS,RD,AMSMI,RDEC,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. USA,RES LABS,ADELPHI,MD 20783. RP Cites, JS (reprint author), AEGIS RES CORP,HUNTSVILLE,AL 35806, USA. NR 9 TC 6 Z9 6 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 11 PY 1996 VL 68 IS 11 BP 1452 EP 1454 DI 10.1063/1.116251 PG 3 WC Physics, Applied SC Physics GA TZ291 UT WOS:A1996TZ29100004 ER PT J AU Jaax, NK AF Jaax, NK TI Research on Ebola virus - Reply SO LANCET LA English DT Letter RP Jaax, NK (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 3 TC 0 Z9 0 U1 1 U2 2 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAR 9 PY 1996 VL 347 IS 9002 BP 691 EP 691 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA TZ285 UT WOS:A1996TZ28500056 ER PT J AU Mol, MAE Smith, WJ AF Mol, MAE Smith, WJ TI Ca2+ homeostasis and Ca2+ signalling in sulphur mustard-exposed normal human epidermal keratinocytes SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE human epidermal keratinocytes; sulphur mustard; cytoplasmic free calcium levels; Fura-2; signal transduction; histamine, ATP ID SULFUR MUSTARD; INTRACELLULAR CALCIUM; CA-2+; GLUTATHIONE; TOXICITY; INCREASE; FURA-2 AB To investigate the role of increased cytoplasmic free calcium levels ([Ca](i)) in sulphur mustard-induced cellular toxicity, the [Ca](i) of human epidermal keratinocytes exposed to sulphur mustard concentrations between 50 and 800 mu M were measured. No early increase in [Ca](i) was observed during the first 20 min after application of the agent. Furthermore, at 3, 6 and 24 h after exposure to sulphur mustard, the [Ca](i) of sulphur mustard-exposed cells differed only slightly from that of control cells. However, sulphur-mustard exposed cells responded with a weaker rise of [Ca](i) upon stimulation with histamine and ATP than control cells. These results suggest that sulphur mustard can induce small increases in [Ca](i), which reflect abnormal cellular physiology rather than acute toxicity. In addition, it has been shown that sulphur mustard disturbs cellular Ca2+ signalling in human epidermal keratinocytes. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP Mol, MAE (reprint author), TNO,PRINS MAURITS LAB,POB 45,2280 AA RIJSWIJK,NETHERLANDS. NR 21 TC 12 Z9 12 U1 1 U2 4 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 8 PY 1996 VL 100 IS 1 BP 85 EP 93 DI 10.1016/S0009-2797(96)03692-7 PG 9 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA UC500 UT WOS:A1996UC50000008 PM 8599858 ER PT J AU Uyehara, CFT Edwards, RM Matsuda, LS Hashiro, GM Gellai, M AF Uyehara, CFT Edwards, RM Matsuda, LS Hashiro, GM Gellai, M TI Increased renal response to vasopressin (VP) during early development of hypertension in spontaneously hypertensive rats (SHR). SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 84 EP 84 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400083 ER PT J AU Claybaugh, JR Sato, AK Crosswhite, LK Hassell, LH AF Claybaugh, JR Sato, AK Crosswhite, LK Hassell, LH TI Reduced diuretic response to water intake at night is accompanied by increased vasopressin in humans. SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 85 EP 85 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400086 ER PT J AU Montain, SJ Kennedy, J Wood, S Shippee, RL AF Montain, SJ Kennedy, J Wood, S Shippee, RL TI Hypertonicity enhances whole blood mitogen proliferation response. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. ROSS PROD DIV ABBOTT LABS,COLUMBUS,OH 43215. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 114 EP 114 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400115 ER PT J AU Matthew, C Osagie, A AF Matthew, C Osagie, A TI Heat acclimated rats: Telemetered blood pressure, heart rate, and temperature. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 650 EP 650 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400650 ER PT J AU Durkot, MJ Francesconi, RP Alkhyyat, AM AF Durkot, MJ Francesconi, RP Alkhyyat, AM TI Potassium deficiency and heat exposure in rats: Effects on Na-K-ATPase activity and ouabain binding sites in selected tissues. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 661 EP 661 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400659 ER PT J AU Young, AJ Lee, DT Sawka, MN Pandolf, KB AF Young, AJ Lee, DT Sawka, MN Pandolf, KB TI Cold induced vasodilation in finger after cold water acclimation. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 669 EP 669 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400669 ER PT J AU Lee, DT Young, AJ Bogart, JE Pandolf, KB AF Lee, DT Young, AJ Bogart, JE Pandolf, KB TI Finger vasodilatory responses in 4 degrees C water SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 670 EP 670 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400671 ER PT J AU Gonzalez, RR Blanchard, LA Charkoudian, N Allison, WF Kolka, MA AF Gonzalez, RR Blanchard, LA Charkoudian, N Allison, WF Kolka, MA TI Thermoregulatory responses to cold transients in resting women. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 671 EP 671 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400670 ER PT J AU Kraning, KK Montain, SJ AF Kraning, KK Montain, SJ TI A computer simulation to predict the physiological effects of progressive dehydration SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 676 EP 676 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400675 ER PT J AU Kiang, JG AF Kiang, JG TI The corticolibrin superfamily increases cytosolic free calcium in human epidermoid A-431 cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 823 EP 823 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400822 ER PT J AU Yan, Z Gemski, P Neill, R Yang, DCH Jett, M AF Yan, Z Gemski, P Neill, R Yang, DCH Jett, M TI Differentiation of staphylococcal enterotoxin B-induced TNF-alpha production and T-cell proliferation. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGETOWN UNIV,DEPT CHEM,WASHINGTON,DC 20007. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 949 EP 949 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28400950 ER PT J AU Liu, CT Kijek, TM Rossi, CA Bushe, TK Carpenter, CB Goodwin, SD Hail, A Creasia, DA Walters, DM Dinterman, RE Mereish, KA AF Liu, CT Kijek, TM Rossi, CA Bushe, TK Carpenter, CB Goodwin, SD Hail, A Creasia, DA Walters, DM Dinterman, RE Mereish, KA TI Staphylococcal enterotoxin B (SEB) kinetics after intratracheal (IT) instillation in Dutch rabbits. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1010 EP 1010 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401009 ER PT J AU Leo, K Grace, J Brewer, T AF Leo, K Grace, J Brewer, T TI Malaria effect on cytochrome P450 in rat liver microsomes. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. AFRIMS,BANGKOK,THAILAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1015 EP 1015 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401014 ER PT J AU Idowu, OR Peggins, J Lin, A Avery, M Brewer, T AF Idowu, OR Peggins, J Lin, A Avery, M Brewer, T TI Identification of in vitro metabolites of dihydroqinghaosu (DQHS) by LC-MS. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MISSISSIPPI,UNIVERSITY,MS 38677. AFRIMS,BANGKOK,THAILAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1016 EP 1016 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401017 ER EF