FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Manco-Johnson, MJ Beckman, MG Goldenberg, NA Thornburg, C Michaels, LA Pipe, SW Moll, S Rodriquez, V Kulkarni, R AF Manco-Johnson, Marilyn J. Beckman, Michele G. Goldenberg, Neil A. Thornburg, Courtney Michaels, Lisa A. Pipe, Steven W. Moll, Stephan Rodriquez, Vilmarie Kulkarni, Roshni TI Risk for Post Thrombotic Syndrome (PTS) Development in Children with Extremity Deep Venous Thrombosis (DVT): Results of the US Centers for Disease Control and Prevention (CDC) Pediatric Thrombosis and Hemostatsis Centers SO BLOOD LA English DT Meeting Abstract CT 51st Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2009 CL New Orleans, LA SP Amer Soc Hematol C1 [Manco-Johnson, Marilyn J.; Goldenberg, Neil A.] Univ Colorado Denver, Mt States Reg Hemophilia & Thrombosis Ctr, Aurora, CO USA. [Manco-Johnson, Marilyn J.; Goldenberg, Neil A.] Childrens Hosp, Aurora, CO USA. [Beckman, Michele G.] CDC, Div Blood Disorders, Atlanta, GA 30333 USA. [Goldenberg, Neil A.] Univ Colorado Denver, Dept Pediat, Aurora, CO USA. [Goldenberg, Neil A.] Univ Colorado Denver, Dept Med, Aurora, CO USA. [Thornburg, Courtney] Duke Univ, Med Ctr, Durham, NC USA. [Michaels, Lisa A.] UMDNJ, Robert Wood Johnson Med Sch, New Brunswick, NJ USA. [Pipe, Steven W.] Univ Michigan, Womens Hosp L2110, Ann Arbor, MI 48109 USA. [Moll, Stephan] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Rodriquez, Vilmarie] Mayo Clin, Rochester, MN USA. [Kulkarni, Roshni] Michigan State Univ, E Lansing, MI 48824 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 20 PY 2009 VL 114 IS 22 BP 1537 EP 1537 PG 1 WC Hematology SC Hematology GA 532DS UT WOS:000272725804664 ER PT J AU Chow, CM Choi, K Nelson, EAS Chan, PKS Mast, TC DiStefano, D Tam, JS Bresee, JS AF Chow, C. M. Choi, Kai Nelson, E. Anthony S. Chan, P. K. S. Mast, T. Christopher DiStefano, D. Tam, John S. Bresee, Joseph S. TI Use of intravenous fluids in Hong Kong children hospitalised for diarrhoea and relationship to severity and aetiology SO VACCINE LA English DT Article DE Diarrhoea; Rotavirus; Clinical; Genotype ID ACUTE GASTROENTERITIS; REHYDRATION THERAPY; ROTAVIRUS DISEASE; MANAGEMENT; BURDEN; EPIDEMIOLOGY; DEHYDRATION; EFFICACY; VACCINE; SAFETY AB This study assessed the clinical management and impact of diarrhoea aetiology (rotavirus positive/negative) and rotavirus genotype on diarrhoea] disease severity. Of 7391 diarrhoea admissions less than 5 years of age over a 2-year period, 80% of patients were tested for rotavirus, 87% were cultured for bacterial pathogens and 78% were assessed for both. Diarrhoeal severity scores were greatest in those children with mixed rotavirus and bacterial infections. Between 1.3 and 8.4% of infants were considered dehydrated yet intravenous fluids were used for 48% of infants (69% rotavirus positive, 72% mixed infection). These findings support the promotion of oral rehydration therapy over intravenous fluids. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Chow, C. M.; Nelson, E. Anthony S.] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China. [Choi, Kai] Chinese Univ Hong Kong, Ctr Biostat & Epidemiol, Hong Kong, Hong Kong, Peoples R China. [Chan, P. K. S.; Tam, John S.] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China. [Mast, T. Christopher; DiStefano, D.] Merck Res Labs, Dept Epidemiol, West Point, PA USA. [Bresee, Joseph S.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Nelson, EAS (reprint author), Prince Wales Hosp, Dept Paediat, 6-F Clin Sci Bldg, Shatin, Hong Kong, Peoples R China. EM tony-nelson@cuhk.edu.hk RI Chan, Paul/J-9360-2013; OI Nelson, Edmund Anthony Severn/0000-0002-2521-3403 FU Merck; GlaxoSmithKline; Hong Kong Research Grants Council; World Health Organization Department of Vaccines and Biologicals; Merck Co., Inc. FX This research project received financial support from the Hong Kong Research Grants Council, World Health Organization Department of Vaccines and Biologicals and Merck & Co., Inc. NR 22 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F55 EP F60 DI 10.1016/j.vaccine.2009.08.062 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000012 PM 19931721 ER PT J AU Flem, ET Kasymbekova, KT Vainio, K Gentsch, J Abdikarimov, ST Glass, RI Bresee, JS AF Flem, Elmira T. Kasymbekova, Kaliya T. Vainio, Kirsti Gentsch, Jon Abdikarimov, Sabirjan T. Glass, Roger I. Bresee, Joseph S. TI Rotavirus infection in hospitalized children and estimates of disease burden in Kyrgyzstan, 2005-2007 SO VACCINE LA English DT Article DE Rotavirus; Gastroenteritis; Epidemiology ID POLYMERASE CHAIN-REACTION; VACCINE; POPULATION; EFFICACY; DEATHS; SAFETY AB To estimate the rotavirus-associated burden in Kyrgyzstan, we conducted hospital surveillance among children <5 years old with diarrhoea during 2005-2007. Of 3756 children hospitalized with diarrhoea, 26% had rotavirus detected in stool samples by an enzyme immunoassay. The virus genotype G1P[8] was identified in 60% of 190 characterized samples from 2005 to 2006. The estimated risk for rotavirus hospitalization by age 5 years was 1 in 28 children. One quarter of all gastroenteritis hospitalizations in children <5 years old in Kyrgyzstan may be attributable to rotavirus. Rotavirus vaccination could be an important health intervention to reduce the burden of rotavirus gastroenteritis. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Flem, Elmira T.; Vainio, Kirsti] Norwegian Inst Publ Hlth, Div Infect Dis Control, N-0403 Oslo, Norway. [Kasymbekova, Kaliya T.; Abdikarimov, Sabirjan T.] Minist Hlth, Dept State Sanit Epidemiol Surveillance, Bishkek, Kyrgyzstan. [Gentsch, Jon; Bresee, Joseph S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int, Bethesda, MD 20892 USA. RP Flem, ET (reprint author), Norwegian Inst Publ Hlth, Div Infect Dis Control, POB 4404, N-0403 Oslo, Norway. EM elmira.flem@fhi.no FU Program for Appropriate Technology in Health (PATH); GAVI Alliance; Research Council of Norway; Norwegian Institute of Public Health; U.S. Centers for Disease Control and Prevention FX This work was performed under a collaborative agreement with the Program for Appropriate Technology in Health (PATH) and was funded in full or in part by the GAVI Alliance, the Research Council of Norway, the Norwegian Institute of Public Health and the U.S. Centers for Disease Control and Prevention. NR 28 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F35 EP F39 DI 10.1016/j.vaccine.2009.08.087 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000008 PM 19931716 ER PT J AU Le, LT Nguyen, TV Nguyen, PM Huong, NT Huong, NT Huong, NTM Hanh, TB Ha, DN Anh, DD Gentsch, JR Wang, YH Esona, MD Glass, RI Steele, AD Kilgore, PE Man, NV Jiang, BM Hien, ND AF Le, Luan T. Nguyen, Trang V. Nguyen, Phuong M. Huong, Nguyen T. Huong, Ngo T. Huong, Nguyen T. M. Hanh, Tran B. Ha, Dang N. Anh, Dang D. Gentsch, Jon R. Wang, Yuhuan Esona, Mathew D. Glass, Roger I. Steele, A. Duncan Kilgore, Paul E. Man, Nguyen V. Jiang, Baoming Hien, Nguyen D. TI Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in Vietnam SO VACCINE LA English DT Article DE Rotavirus vaccine; Diarrhoea; Vietnam ID POLYMERASE-CHAIN-REACTION; SEQUENCE-ANALYSIS; IDENTIFICATION; VIRUSES; BURDEN AB In Vietnam, rotavirus infection accounts for more than one-half of all hospitalizations for diarrhoea among children less than 5 years of age. While new vaccines to prevent rotavirus diarrhoea have been developed and introduced into some countries by multinational manufacturers, the ability for developing countries such as Vietnam to introduce several new and important vaccines into the routine infant immunization schedule may be challenging. In order to be partially self-sufficient in vaccine production, Vietnam has pursued the development of several rotavirus strains as candidate vaccines using isolates obtained from Vietnamese children with diarrhoea. This paper describes the origin, isolation and characterization of 3 human rotavirus strains being considered for further vaccine development in Vietnam. The goal is to prepare a monovalent G1P [8] rotavirus vaccine using one of these strains obtained in Vietnam and naturally attenuated by multiple passages in cell culture. While this is an ambitious project that will require several years' work, we are using the lessons learned to improve the overall quality of vaccine production including the use of Vero cell techniques for the manufacture of other vaccines in Vietnam. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Le, Luan T.; Huong, Nguyen T.; Huong, Ngo T.; Huong, Nguyen T. M.; Hanh, Tran B.; Ha, Dang N.; Man, Nguyen V.; Hien, Nguyen D.] POLYVAC, Ctr Res & Prod Vaccines & Biol, Hanoi, Vietnam. [Nguyen, Trang V.; Nguyen, Phuong M.; Anh, Dang D.] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam. [Gentsch, Jon R.; Wang, Yuhuan; Esona, Mathew D.; Jiang, Baoming] US Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Steele, A. Duncan] PATH, Seattle, WA USA. [Kilgore, Paul E.] Int Vaccine Inst, Seoul, South Korea. RP Le, LT (reprint author), POLYVAC, Ctr Res & Prod Vaccines & Biol, 135 Loduc St, Hanoi, Vietnam. EM luanpolyvac@gmail.com; bxj4@cdc.gov RI Kilgore, Paul/L-1462-2013 OI Kilgore, Paul/0000-0003-3214-4482 FU Ministry of Health and the Ministry of Science and Technology, Vietnam; World Health Organisation FX Supported by grants form the Ministry of Health and the Ministry of Science and Technology, Vietnam, and the World Health Organisation. NR 14 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 SU 5 BP F130 EP F138 DI 10.1016/j.vaccine.2009.08.086 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000026 ER PT J AU Mirzayeva, R Steele, AD Parashar, UD Zaman, K Neuzil, KM Nelson, EAS AF Mirzayeva, R. Steele, A. D. Parashar, U. D. Zaman, K. Neuzil, K. M. Nelson, E. A. S. TI Evaluation of rotavirus vaccines in Asia-Are there lessons to be learnt? SO VACCINE LA English DT Article DE Rotavirus; Vaccines; Clinical trials ID DEVELOPING-COUNTRIES; POLIOVIRUS VACCINES; CONTROLLED-TRIAL; HEALTHY INFANTS; THAI INFANTS; DOUBLE-BLIND; IMMUNOGENICITY; SAFETY; SURVEILLANCE; INDIA AB Rotavirus mortality is highest in the Asia-Pacific region and rotavirus vaccines could have enormous impact here. Yet, live-attenuated orally administered rotavirus vaccines have been evaluated in a small number of immunogenicity studies in some Asian countries, where the immune responses have been documented to be moderate in low-income countries with high diarrhoeal disease burden and mortality, and high in middle-/high-income countries with little reported rotavirus deaths. This review of these rotavirus clinical trials examines the results observed and attempts to draw lessons to inform decision-making, aid design of additional clinical trials and guide vaccine development by local manufacturers. (C) 2009 Elsevier Ltd. All rights reserved C1 [Steele, A. D.; Neuzil, K. M.] PATH, Seattle, WA 98107 USA. [Mirzayeva, R.] PATH, Ferney Voltaire, France. [Parashar, U. D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Epidemiol Branch, Atlanta, GA USA. [Zaman, K.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Neuzil, K. M.] Univ Washington, Dept Med, Seattle, WA USA. [Neuzil, K. M.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [Nelson, E. A. S.] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China. [Steele, A. D.] WHO, Initiat Vaccine Res, CH-1211 Geneva, Switzerland. RP Steele, AD (reprint author), PATH, 1455 Leary Way NW, Seattle, WA 98107 USA. EM dsteele@path.org OI Nelson, Edmund Anthony Severn/0000-0002-2521-3403 FU Merck; GlaxoSmithKline FX EASN has received funding and support from Merck for rotavirus surveillance studies, has participated in a rotavirus vaccine study funded by GlaxoSmithKline, and has received lecture fees and travel support from Merck and GIaxoSmithKline. NR 51 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F120 EP F129 DI 10.1016/j.vaccine.2009.09.039 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000025 PM 19931711 ER PT J AU Nelson, EAS Widdowson, MA Kilgore, PE Steele, D Parashar, UD AF Nelson, E. Anthony S. Widdowson, Marc-Alain Kilgore, Paul E. Steele, Duncan Parashar, Umesh D. TI A decade of the Asian Rotavirus Surveillance Network: Achievements and future directions SO VACCINE LA English DT Editorial Material DE Rotavirus; Vaccines; Disease burden; Economic analysis; GAVI Alliance; GIVS ID COST-EFFECTIVENESS; VACCINATION; VACCINES; GASTROENTERITIS; CHILDREN; CARE C1 [Nelson, E. Anthony S.] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China. [Widdowson, Marc-Alain; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Epidemiol Branch, Atlanta, GA USA. [Kilgore, Paul E.] Int Vaccine Inst, Div Translat Res, Seoul, South Korea. [Steele, Duncan] PATH, Seattle, WA 98107 USA. RP Nelson, EAS (reprint author), Prince Wales Hosp, 6-F Clin Sci Bldg, Shatin, Hong Kong, Peoples R China. EM tony-nelson@cuhk.edu.hk RI Kilgore, Paul/L-1462-2013; OI Kilgore, Paul/0000-0003-3214-4482; Widdowson, Marc-Alain/0000-0002-0682-6933; Nelson, Edmund Anthony Severn/0000-0002-2521-3403 NR 19 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F1 EP F3 DI 10.1016/j.vaccine.2009.09.001 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000001 PM 19931705 ER PT J AU Tate, JE Chitambar, S Esposito, DH Sarkar, R Gladstone, B Ramani, S Raghava, MV Sowmyanarayanan, TV Gandhe, S Arora, R Parashar, UD Kang, G AF Tate, Jacqueline E. Chitambar, Shobha Esposito, Douglas H. Sarkar, Rajiv Gladstone, Beryl Ramani, Sasirekha Raghava, Mohan Venkata Sowmyanarayanan, Thuppal V. Gandhe, Swati Arora, Rashmi Parashar, Umesh D. Kang, Gagandeep TI Disease and economic burden of rotavirus diarrhoea in India SO VACCINE LA English DT Article DE Rotavirus; Disease burden; India ID SOUTH-INDIA; COST-EFFECTIVENESS; BIRTH COHORT; CHILDREN; EPIDEMIOLOGY; VACCINATION; INFECTION; EFFICACY; VELLORE; SAFETY AB We used published and unpublished studies and national statistics to estimate the number of deaths, hospitalizations, and outpatient visits due to rotavirus diarrhoea and the associated national economic burden of disease in India. Annually in India, rotavirus diarrhoea causes an estimated 122,000-153,000 deaths. 457,000-884,000 hospitalizations, and 2 million outpatient visits in children <5 years of age. India spends Rs 2.0-3.4 billion (US$ 41-72 million) annually in medical costs to treat rotavirus diarrhoea. The use of specific interventions against rotavirus, such as newly available vaccines, would help prevent much of this large disease and economic burden. Published by Elsevier Ltd. C1 [Kang, Gagandeep] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India. [Tate, Jacqueline E.; Esposito, Douglas H.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chitambar, Shobha; Gandhe, Swati] Natl Inst Virol, Pune, Maharashtra, India. [Arora, Rashmi] Indian Council Med Res, New Delhi, India. RP Kang, G (reprint author), Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India. EM gkang@cmcvellore.ac.in NR 24 TC 60 Z9 62 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F18 EP F24 DI 10.1016/j.vaccine.2009.08.098 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000005 PM 19931713 ER PT J AU Wilopo, SA Soenarto, Y Bresee, JS Tholib, A Aminah, S Cahyono, A Gentsch, JR Kilgore, P Glass, RI AF Wilopo, Siswanto Agus Soenarto, Yati Bresee, Joseph S. Tholib, Abu Aminah, Sri Cahyono, Anton Gentsch, Jon R. Kilgore, Paul Glass, Roger I. TI Rotavirus surveillance to determine disease burden and epidemiology in Java, Indonesia, August 2001 through April 2004 SO VACCINE LA English DT Article DE Epidemiology; Gastroenteritis; Rotavirus; Burden of disease; Indonesia ID ACUTE DIARRHEA; HONG-KONG; CHILDREN; GASTROENTERITIS; INFECTION; MORTALITY; VACCINES; JAKARTA; NETWORK AB This study estimates rotavirus disease burden in children under age 3 years presenting with acute gastroenteritis to hospitals in Purworejo district and Yogyakarta city from August 2001 to April 2004. Among a total of 8929 hospitalized children, 1397 (16%) presented with acute gastroenteritis and of the 1321 stool samples tested, 705 (53%) were positive for rotavirus. Rotavirus infections were most common among children aged 7-23 months and rotavirus was more common during the dry season (June through August). Logistic regression analysis showed no differences in socioeconomic indicators between the rotavirus positive and negative admissions. Rotavirus vaccination may prevent a large proportion of all hospitalizations of young children under 3 years of age presenting with acute gastroenteritis. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Wilopo, Siswanto Agus] Gadjah Mada Univ, CHN RL, Yogyakarta, Indonesia. [Wilopo, Siswanto Agus] Gadjah Mada Univ, Dept Publ Hlth, Yogyakarta, Indonesia. [Soenarto, Yati] Dr Sardjito Hosp, Dept Pediat, Yogyakarta, Indonesia. [Bresee, Joseph S.; Gentsch, Jon R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tholib, Abu] Gadjah Mada Univ, Dept Microbiol, Fac Med, Bulaksumur 55281, Yogyakarta, Indonesia. [Aminah, Sri] RSUD Wirosaban Hosp, Dept Pediat, Yogyakarta, Indonesia. [Cahyono, Anton] RSUD Purworedjo Dist Hosp, Dept Pediat, Purworedjo, Indonesia. [Kilgore, Paul] Int Vaccine Inst, Seoul, South Korea. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Wilopo, SA (reprint author), Gadjah Mada Univ, Ctr Reprod Hlth, Dept Publ Hlth, Fac Med, IKM Bldg 1st Floor,Farmako 1 St,Sekip Utara, Bulaksumur 55281, Yogyakarta, Indonesia. EM sawilopo@yahoo.com RI Kilgore, Paul/L-1462-2013 OI Kilgore, Paul/0000-0003-3214-4482 FU Rotavirus Vaccine Program, PATH [GAV.1142-01-07211-SPS] FX This work was performed under a collaborative arrangement with PATH and CDC and was funded in full or in part by the Rotavirus Vaccine Program, PATH (GAV.1142-01-07211-SPS). NR 28 TC 5 Z9 5 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F61 EP F66 DI 10.1016/j.vaccine.2009.09.004 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000013 PM 19931722 ER PT J AU Yee, EL Fang, ZY Liu, N Hadler, SC Liang, XF Wang, HQ Zhu, X Jiang, BM Parashar, U Widdowson, MA Glass, RI AF Yee, Eileen L. Fang, Zhao-Yin Liu, Na Hadler, Stephen C. Liang, Xiaofeng Wang, Huaqing Zhu, Xu Jiang, Baoming Parashar, Umesh Widdowson, Marc-Alain Glass, Roger I. TI Importance and challenges of accurately counting rotavirus deaths in China, 2002 SO VACCINE LA English DT Article DE Rotavirus; Mortality; Vaccine ID CHILDREN; DIARRHEA; DISEASE; BURDEN AB Rotavirus mortality is an important component of the total burden of rotavirus disease for children under 5 years old, but accurate estimation is difficult for many developing countries. Here we applied a more direct method to improve estimates of rotavirus mortality in China using 2002 Chinese-specific data. Results indicate that in 2002, approximately 13,400 children under 5 years old in China died from rotavirus and 70% of these deaths occur in rural areas. Thus, a national rotavirus immunization program targeting rural areas with high mortality from diarrhoea could dramatically reduce these deaths and urban areas could reduce childhood hospitalizations attributed to rotavirus by 43%. Published by Elsevier Ltd. C1 [Yee, Eileen L.; Jiang, Baoming; Parashar, Umesh; Widdowson, Marc-Alain; Glass, Roger I.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, Atlanta, GA 30333 USA. [Fang, Zhao-Yin; Liu, Na] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Viral Gastroenteritis Div, Beijing, Peoples R China. [Hadler, Stephen C.] WHO, Expanded Programme Immunizat, Beijing, Peoples R China. [Liang, Xiaofeng; Wang, Huaqing] Chinese Ctr Dis Control & Prevent, Natl Immunizat Program, Beijing, Peoples R China. [Zhu, Xu] UNICEF China, Hlth Nutr & WES Sect, Beijing, Peoples R China. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Yee, EL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, 1600 Clifton Rd NE,MS E02, Atlanta, GA 30333 USA. EM bwd3@cdc.gov OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU Centers for Disease Control and Prevention FX This Study was supported by the Centers for Disease Control and Prevention. NR 12 TC 11 Z9 12 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 20 PY 2009 VL 27 BP F46 EP F49 DI 10.1016/j.vaccine.2009.08.065 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 541KQ UT WOS:000273415000010 PM 19931719 ER PT J AU Stommel, M Schoenborn, CA AF Stommel, Manfred Schoenborn, Charlotte A. TI Accuracy and usefulness of BMI measures based on self-reported weight and height: findings from the NHANES & NHIS 2001-2006 SO BMC PUBLIC HEALTH LA English DT Article ID BODY-MASS-INDEX; NUTRITION EXAMINATION SURVEY; WAIST CIRCUMFERENCE; NATIONAL-HEALTH; POPULATION; VALIDITY; US; PREVALENCE; PREDICTION; OBESITY AB Background: The Body Mass Index (BMI) based on self-reported height and weight ("self-reported BMI") in epidemiologic studies is subject to measurement error. However, because of the ease and efficiency in gathering height and weight information through interviews, it remains important to assess the extent of error present in self-reported BMI measures and to explore possible adjustment factors as well as valid uses of such self-reported measures. Methods: Using the combined 2001-2006 data from the continuous National Health and Nutrition Examination Survey, discrepancies between BMI measures based on self-reported and physical height and weight measures are estimated and socio-demographic predictors of such discrepancies are identified. Employing adjustments derived from the socio-demographic predictors, the self-reported measures of height and weight in the 2001-2006 National Health Interview Survey are used for population estimates of overweight & obesity as well as the prediction of health risks associated with large BMI values. The analysis relies on two-way frequency tables as well as linear and logistic regression models. All point and variance estimates take into account the complex survey design of the studies involved. Results: Self-reported BMI values tend to overestimate measured BMI values at the low end of the BMI scale (< 22) and underestimate BMI values at the high end, particularly at values > 28. The discrepancies also vary systematically with age (younger and older respondents underestimate their BMI more than respondents aged 42-55), gender and the ethnic/racial background of the respondents. BMI scores, adjusted for socio-demographic characteristics of the respondents, tend to narrow, but do not eliminate misclassification of obese people as merely overweight, but health risk estimates associated with variations in BMI values are virtually the same, whether based on self-report or measured BMI values. Conclusion: BMI values based on self-reported height and weight, if corrected for biases associated with socio-demographic characteristics of the survey respondents, can be used to estimate health risks associated with variations in BMI, particularly when using parametric prediction models. C1 [Stommel, Manfred] Michigan State Univ, Coll Nursing, E Lansing, MI 48825 USA. [Schoenborn, Charlotte A.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Stommel, M (reprint author), Michigan State Univ, Coll Nursing, W-149 Owen Grad Ctr, E Lansing, MI 48825 USA. EM stommel@msu.edu; CSchoenborn@cdc.gov FU National Center for Health Statistics and Professor; Health Services Research; College of Nursing, Michigan State University FX MS is the 2008-2009 Academy Health Senior Service Fellow at the National Center for Health Statistics and Professor, Health Services Research, College of Nursing, Michigan State University NR 26 TC 190 Z9 191 U1 0 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD NOV 19 PY 2009 VL 9 AR 421 DI 10.1186/1471-2458-9-421 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 528MT UT WOS:000272450600001 PM 19922675 ER PT J AU Pearson, T Giffard, P Beckstrom-Sternberg, S Auerbach, R Hornstra, H Tuanyok, A Price, EP Glass, MB Leadem, B Beckstrom-Sternberg, JS Allan, GJ Foster, JT Wagner, DM Okinaka, RT Sim, SH Pearson, O Wu, ZN Chang, J Kaul, R Hoffmaster, AR Brettin, TS Robison, RA Mayo, M Gee, JE Tan, P Currie, BJ Keim, P AF Pearson, Talima Giffard, Philip Beckstrom-Sternberg, Stephen Auerbach, Raymond Hornstra, Heidie Tuanyok, Apichai Price, Erin P. Glass, Mindy B. Leadem, Benjamin Beckstrom-Sternberg, James S. Allan, Gerard J. Foster, Jeffrey T. Wagner, David M. Okinaka, Richard T. Sim, Siew Hoon Pearson, Ofori Wu, Zaining Chang, Jean Kaul, Rajinder Hoffmaster, Alex R. Brettin, Thomas S. Robison, Richard A. Mayo, Mark Gee, Jay E. Tan, Patrick Currie, Bart J. Keim, Paul TI Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer SO BMC BIOLOGY LA English DT Article ID SINGLE-NUCLEOTIDE POLYMORPHISMS; SEQUENCE TYPING DATA; BURKHOLDERIA-PSEUDOMALLEI; ESCHERICHIA-COLI; NEISSERIA-MENINGITIDIS; STAPHYLOCOCCUS-AUREUS; CLINICAL PRESENTATION; POPULATION-STRUCTURE; NORTHERN AUSTRALIA; BACILLUS-ANTHRACIS AB Background: Phylogeographic reconstruction of some bacterial populations is hindered by low diversity coupled with high levels of lateral gene transfer. A comparison of recombination levels and diversity at seven housekeeping genes for eleven bacterial species, most of which are commonly cited as having high levels of lateral gene transfer shows that the relative contributions of homologous recombination versus mutation for Burkholderia pseudomallei is over two times higher than for Streptococcus pneumoniae and is thus the highest value yet reported in bacteria. Despite the potential for homologous recombination to increase diversity, B. pseudomallei exhibits a relative lack of diversity at these loci. In these situations, whole genome genotyping of orthologous shared single nucleotide polymorphism loci, discovered using next generation sequencing technologies, can provide very large data sets capable of estimating core phylogenetic relationships. We compared and searched 43 whole genome sequences of B. pseudomallei and its closest relatives for single nucleotide polymorphisms in orthologous shared regions to use in phylogenetic reconstruction. Results: Bayesian phylogenetic analyses of > 14,000 single nucleotide polymorphisms yielded completely resolved trees for these 43 strains with high levels of statistical support. These results enable a better understanding of a separate analysis of population differentiation among > 1,700 B. pseudomallei isolates as defined by sequence data from seven housekeeping genes. We analyzed this larger data set for population structure and allele sharing that can be attributed to lateral gene transfer. Our results suggest that despite an almost panmictic population, we can detect two distinct populations of B. pseudomallei that conform to biogeographic patterns found in many plant and animal species. That is, separation along Wallace's Line, a biogeographic boundary between Southeast Asia and Australia. Conclusion: We describe an Australian origin for B. pseudomallei, characterized by a single introduction event into Southeast Asia during a recent glacial period, and variable levels of lateral gene transfer within populations. These patterns provide insights into mechanisms of genetic diversification in B. pseudomallei and its closest relatives, and provide a framework for integrating the traditionally separate fields of population genetics and phylogenetics for other bacterial species with high levels of lateral gene transfer. C1 [Pearson, Talima; Beckstrom-Sternberg, Stephen; Auerbach, Raymond; Hornstra, Heidie; Tuanyok, Apichai; Price, Erin P.; Leadem, Benjamin; Foster, Jeffrey T.; Wagner, David M.; Okinaka, Richard T.; Keim, Paul] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Giffard, Philip; Mayo, Mark; Currie, Bart J.] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove, Australia. [Giffard, Philip] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia. [Beckstrom-Sternberg, Stephen; Price, Erin P.; Beckstrom-Sternberg, James S.; Keim, Paul] Translat Genom Res Inst, Pathogen Genom Div, Phoenix, AZ USA. [Glass, Mindy B.; Hoffmaster, Alex R.; Gee, Jay E.] Ctr Dis Control & Prevent, Bacterial Zoonoses Branch, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Allan, Gerard J.] No Arizona Univ, Dept Biol Sci, Environm Genet & Genom Facil, Flagstaff, AZ 86011 USA. [Okinaka, Richard T.] Los Alamos Natl Lab, Los Alamos, NM USA. [Sim, Siew Hoon; Tan, Patrick] Def Med & Environm Res Inst, Singapore, Singapore. [Pearson, Ofori] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. [Wu, Zaining; Chang, Jean; Kaul, Rajinder] Univ Washington, Genome Ctr, Seattle, WA 98195 USA. [Wu, Zaining; Chang, Jean; Kaul, Rajinder] Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA. [Brettin, Thomas S.] Los Alamos Natl Lab, DOE, Joint Genome Inst, Biosci Div, Los Alamos, NM USA. [Robison, Richard A.] Brigham Young Univ, Dept Mol Biol & Microbiol, Provo, UT 84602 USA. [Tan, Patrick] Genome Inst Singapore, Singapore, Singapore. [Currie, Bart J.] Royal Darwin Hosp, No Terr Clin Sch, Darwin, NT, Australia. [Auerbach, Raymond] Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA. RP Keim, P (reprint author), No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. EM Talima.Pearson@NAU.edu; Phil.Giffard@menzies.edu.au; sbeckstrom@tgen.org; Raymond.Auerbach@yale.edu; Heidie.Hornstra-ONeill@nau.edu; apichai.tuanyok@nau.edu; Erin.price@nau.edu; wzg0@cdc.gov; bleadem1@jhu.edu; jbeckstrom@tgen.org; Gery.allan@nau.edu; jeff.foster@nau.edu; dave.wagner@nau.edu; Richard.Okinaka@nau.edu; ssiewhoo@dso.org.sg; opearson@usgs.gov; znwu@u.washington.edu; mspiggy1@u.washington.edu; rkkaul@u.washington.edu; amh9@cdc.gov; brettin@lanl.gov; richard_robison@byu.edu; Mark.mayo@menzies.edu.au; xzg4@cdc.gov; gmstanp@nus.edu.sg; bart@menzies.edu.au; paul.keim@nau.edu RI Wagner, David/A-5125-2010; Keim, Paul/A-2269-2010; Giffard, Philip/N-2293-2013; Price, Erin/N-2336-2013; OI Price, Erin/0000-0002-1079-4882; Robison, Richard/0000-0002-4324-5169; Foster, Jeffrey/0000-0001-8235-8564 FU U.S. Department of Homeland Security S&T CB Division Bioforensics R&D Program, NIH-NIAID [U54AI-56359, U01AI-075568]; Australian National Health and Medical Research Council [383504] FX We would like to thank Richard Lenski for helpful comments on a previous version of this manuscript. This work was supported by the U.S. Department of Homeland Security S&T CB Division Bioforensics R&D Program, NIH-NIAID grants U54AI-56359 and U01AI-075568, and Project Grant (no. 383504) from the Australian National Health and Medical Research Council. Use of products/names does not constitute endorsement by DHS of USG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 79 TC 67 Z9 68 U1 2 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1741-7007 J9 BMC BIOL JI BMC Biol. PD NOV 18 PY 2009 VL 7 AR 78 DI 10.1186/1741-7007-7-78 PG 14 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 526ZW UT WOS:000272336500001 PM 19922616 ER PT J AU Euler, GL Lu, PJ Shefer, A Singleton, JA Fiore, A Town, M Balluz, L AF Euler, G. L. Lu, P. J. Shefer, A. Singleton, J. A. Fiore, A. Town, M. Balluz, L. TI Influenza Vaccination Coverage Among Children and Adults-United States, 2008-09 Influenza Season (Reprinted from MMWR, vol 58, pg 1091-1095, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Town, M.; Balluz, L.] CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 2 TC 2 Z9 2 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 18 PY 2009 VL 302 IS 19 BP 2085 EP 2086 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 520UG UT WOS:000271873900011 ER PT J AU Kuklina, EV Yoon, PW Keenan, NL AF Kuklina, Elena V. Yoon, Paula W. Keenan, Nora L. TI Trends in High Levels of Low-Density Lipoprotein Cholesterol in the United States, 1999-2006 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID NUTRITION EXAMINATION SURVEY; CORONARY-HEART-DISEASE; NATIONAL-HEALTH; DYSLIPIDEMIA; GUIDELINES; PREVENTION; DIAGNOSIS; QUALITY; RISK; CARE AB Context Studies show that a large proportion of adults with high levels of low-density lipoprotein cholesterol (LDL-C) remain untreated or undertreated despite growing use of lipid-lowering medications. Objective To investigate trends in screening prevalence, use of cholesterol-lowering medications, and LDL-C levels across 4 study cycles (1999-2000, 20012002, 2003-2004, and 2005-2006). Design, Setting, and Participants The National Health and Nutrition Examination Survey (NHANES) is a cross-sectional, stratified, multistage probability sample survey of the US civilian, noninstitutionalized population. After we restricted the study sample to fasting participants aged 20 years or older (n=8018) and excluded pregnant women (n=464) and participants with missing data (n=510), our study sample consisted of 7044 participants. Main Outcome Measure High LDL-C levels, defined as levels above the specific goal for each risk category outlined in guidelines from the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). All presented results are weighted and age-standardized to 2000 standard population estimates. Results Prevalence of high LDL-C levels among persons aged 20 years or older decreased from 31.5% in 1999-2000 to 21.2% in 2005-2006 (P<.001 for linear trend) but varied by risk category. By the 2005-2006 study cycle, prevalence of high LDL-C was 58.9%, 30.2%, and 11.0% for high-, intermediate-, and low-risk categories, respectively. Self-reported use of lipid-lowering medications increased from 8.0% to 13.4% (P<.001 for linear trend), but screening rates did not change significantly, remaining less than 70% (P=.16 for linear trend) during the study periods. Conclusions Among the NHANES population aged 20 years or older, the prevalence of high LDL-C levels decreased from 1999-2000 to 2005-2006. In the most recent period, the prevalence was 21.2%. JAMA. 2009; 302(19): 2104-2110 C1 [Kuklina, Elena V.; Yoon, Paula W.; Keenan, Nora L.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kuklina, EV (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mailstop K-37, Atlanta, GA 30341 USA. EM ekuklina@cdc.gov NR 26 TC 67 Z9 69 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 18 PY 2009 VL 302 IS 19 BP 2104 EP 2110 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 520UG UT WOS:000271873900019 PM 19920234 ER PT J AU Morick, D Baneth, G Avidor, B Kosoy, MY Mumcuoglu, KY Mintz, D Eyal, O Goethe, R Mietze, A Shpigel, N Harrus, S AF Morick, Danny Baneth, Gad Avidor, Boaz Kosoy, Michael Y. Mumcuoglu, Kosta Y. Mintz, Dvir Eyal, Osnat Goethe, Ralph Mietze, Andreas Shpigel, Nahum Harrus, Shimon TI Detection of Bartonella spp. in wild rodents in Israel using HRM real-time PCR SO VETERINARY MICROBIOLOGY LA English DT Article DE Bartonella tribocorum; Bartonella elizabethae; Rattus rattus; Acomys cahirinus; Zoonosis; HRM real-time PCR ID HOST-SPECIFICITY; PATIENT; ELIZABETHAE; INFECTION; MAMMALS; GENE; RATS AB The prevalence of Bartonella spp. in wild rodents was studied in 19 geographical locations in Israel. One hundred and twelve rodents belonging to five species (Mus musculus, Rattus rattus, Microtus socialis, Acomys cahirinus and Apodemus sylvaticus) were included in the survey. In addition, 156 ectoparasites were collected from the rodents. Spleen sample from each rodent and the ectoparasites were examined for the presence of Bartonella DNA using high resolution melt (HRM) real-time PCR. The method was designed for the simultaneous detection and differentiation of eight Bartonella spp. according to the nucleotide variation in each of two gene fragments (rpoB and gltA) and the 16S-23S intergenic spacer (ITS) locus, using the same PCR protocol which allowed the simultaneous amplification of the three different loci. Bartonella DNA was detected in spleen samples of 19 out of 79 (24%) black rats (R. rattus) and in 1 of 4 (25%) Cairo spiny mice (A. cahirinus). In addition, 15 of 34 (44%) flea pools harbored Bartonella DNA. Only rat flea (Xenopsyla cheopis) pools collected from black rats (R. rattus) were positive for Bartonella DNA. The Bartonella sp. detected in spleen samples from black rats (R. rattus) was closely related to both B. tribocorum and B. elizabethae. The species detected in the Cairo spiny mouse (A. cahirinus) spleen sample was closely related to the zoonotic pathogen, B. elizabethae. These results indicate that Bartonella species are highly prevalent in suburban rodent populations and their ectoparasites in Israel. Further investigation of the prevalence and zoonotic potential of the Bartonella species detected in the black rats and the Cairo spiny mouse is warranted. (C) 2009 Elsevier B.V. All rights reserved. C1 [Morick, Danny; Baneth, Gad; Mintz, Dvir; Eyal, Osnat; Shpigel, Nahum; Harrus, Shimon] Hebrew Univ Jerusalem, Koret Sch Vet Med, IL-76100 Rehovot, Israel. [Avidor, Boaz] Tel Aviv Sourasky Med Ctr, Lab Viruses & Mol Biol, Tel Aviv, Israel. [Kosoy, Michael Y.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Mumcuoglu, Kosta Y.] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Parasitol, IL-91010 Jerusalem, Israel. [Goethe, Ralph; Mietze, Andreas] Univ Vet Med Hannover, Inst Mikrobiol, Zentrum Infekt Med, D-30173 Hannover, Germany. RP Harrus, S (reprint author), Hebrew Univ Jerusalem, Sch Vet Med, POB 12, IL-76100 Rehovot, Israel. EM harrus@agri.huji.ac.il RI Harrus, Shimon/H-5175-2016; Baneth, Gad/H-5773-2016 OI Harrus, Shimon/0000-0003-0542-207X; FU The Niedersachsen-Israel cooperation fund [VWZN2176] FX This study was sponsored by The Niedersachsen-Israel cooperation fund (# VWZN2176). The authors would like to acknowledge Dr. Gunter C. Muller for his professional assistance. NR 22 TC 24 Z9 27 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1135 J9 VET MICROBIOL JI Vet. Microbiol. PD NOV 18 PY 2009 VL 139 IS 3-4 BP 293 EP 297 DI 10.1016/j.vetmic.2009.06.019 PG 5 WC Microbiology; Veterinary Sciences SC Microbiology; Veterinary Sciences GA 519OG UT WOS:000271775700011 PM 19595521 ER PT J AU Basri, C Bergstrom, K Walton, W Surya, A Voskens, J Metha, F AF Basri, Carmelia Bergstrom, Karin Walton, Wanda Surya, Asik Voskens, Jan Metha, Firdosi TI Sustainable scaling up of good quality health worker education for tuberculosis control in Indonesia: a case study SO HUMAN RESOURCES FOR HEALTH LA English DT Article AB Background: In 2000, an external review mission of the National Tuberculosis Control Programme of Indonesia identified suboptimal results of TB control activities. This led to a prioritization on human resource capacity building representing a major shift in the approach following the recommendations of the external review team. Case description: The National Tuberculosis Control Programme (NTP) used a systematic process to develop and implement two strategic action plans focussing on competence development based on specific job descriptions. The approach was a change from only focussing on training, to a broader, long term approach to human resource development for comprehensive TB control. A structured plan for capacity building, including standardized competency based training modules and curricula, was developed in the first phase. This was supported by an organisational system comprised of a training focal point, master trainers, and regional training centres in which nationwide training of supervisors was implemented. Training was expanded to the health service delivery level in the second phase, as well as broadened in the scope of activities beyond training to also include other aspects of human resource development. Discussion and evaluation: The result was improved technical and managerial capacity of health workers for TB control at all levels. The impact on case detection and treatment outcome was spectacular, with major improvements in quality of all aspects of service delivery. Conclusion: The strategic decision by the NTP in 2000 to put the highest priority on capacity building has resulted in impressive progress towards TB control targets, a progress that despite many challenges has been sustained. C1 [Bergstrom, Karin] WHO, Stop TB Dept, CH-1211 Geneva, Switzerland. [Basri, Carmelia; Surya, Asik] Minist Hlth, Natl TB Control Programme, Jakarta, Indonesia. [Walton, Wanda] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Voskens, Jan] KNCV, The Hague, Netherlands. [Metha, Firdosi] WHO, Jakarta, Indonesia. RP Bergstrom, K (reprint author), WHO, Stop TB Dept, CH-1211 Geneva, Switzerland. EM c_basri@yahoo.com; bergstromk@who.int; wxw2@cdc.gov; kingasik@yahoo.com; voskensj@kncvtbc.nl; methaf@who.or.id NR 7 TC 2 Z9 2 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-4491 J9 HUM RESOUR HEALTH JI Hum. Resour. Health PD NOV 16 PY 2009 VL 7 AR 85 DI 10.1186/1478-4491-7-85 PG 9 WC Health Policy & Services; Industrial Relations & Labor SC Health Care Sciences & Services; Business & Economics GA 525NF UT WOS:000272222100001 PM 19917095 ER PT J AU Dawood, FS Dalton, CB Durrheim, DN Hope, KG AF Dawood, Fatimah S. Dalton, Craig B. Durrheim, David N. Hope, Kirsty G. TI Rates of hospitalisation for acute respiratory illness and the emergence of pandemic (H1N1) 2009 virus in the Hunter New England Area Health Service SO MEDICAL JOURNAL OF AUSTRALIA LA English DT Letter ID INFLUENZA C1 [Dawood, Fatimah S.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Dalton, Craig B.; Durrheim, David N.] Hunter New England Populat Hlth, Newcastle, NSW, Australia. RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM fdawood@cdc.gov NR 5 TC 3 Z9 3 U1 1 U2 1 PU AUSTRALASIAN MED PUBL CO LTD PI PYRMONT PA LEVEL 2, 26-32 PYRMONT BRIDGE RD, PYRMONT, NSW 2009, AUSTRALIA SN 0025-729X J9 MED J AUSTRALIA JI Med. J. Aust. PD NOV 16 PY 2009 VL 191 IS 10 BP 573 EP 574 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 537GW UT WOS:000273102200016 PM 19912093 ER PT J AU Reiter, PL Brewer, NT Gottlieb, SL Mcree, AL Smith, JS AF Reiter, Paul L. Brewer, Noel T. Gottlieb, Sami L. McRee, Annie-Laurie Smith, Jennifer S. TI How much will it hurt? HPV vaccine side effects and influence on completion of the three-dose regimen SO VACCINE LA English DT Article DE HPV; Vaccine; Side effects ID ACELLULAR PERTUSSIS-VACCINE; HUMAN-PAPILLOMAVIRUS TYPE-6; SAFETY; ADOLESCENTS; DIPHTHERIA; IMMUNOGENICITY; ATTITUDES AB We examined the prevalence of reported pain following human papillomavirus (HPV) vaccination and whether it differed from that for other adolescent vaccines or affected completion of the HPV vaccine regimen. In 2008,we conducted cross-sectional surveys with parents of adolescent girls aged 11-20 living in areas of North Carolina with elevated cervical cancer rates who had received at least one dose of HPV vaccine. Pain from HPV vaccination, while commonly reported by parents, was less frequent compared to other adolescent vaccines and did not appear to affect vaccine regimen completion. These findings may be important to increase HPV vaccination coverage. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Reiter, Paul L.] Univ N Carolina, Gllings Sch Global Publ Hlth, Dept Hlth Behav & Hlth Educ, Chapel Hill, NC 27599 USA. [Gottlieb, Sami L.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Reiter, PL (reprint author), Univ N Carolina, Gllings Sch Global Publ Hlth, Dept Hlth Behav & Hlth Educ, 323D Rosenau Hall,CB 7440, Chapel Hill, NC 27599 USA. EM preiter@email.unc.edu RI McRee, Annie/J-3077-2013 FU Centers for Disease Control and Prevention [S3715-25/25]; American Cancer Society [MSRG-06-259-01-CPPB]; National Cancer Institute [R25 CA57726] FX This study was funded by grants from the Centers for Disease Control and Prevention (S3715-25/25), the American Cancer Society (MSRG-06-259-01-CPPB), and the National Cancer Institute (R25 CA57726). NR 25 TC 17 Z9 18 U1 3 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 16 PY 2009 VL 27 IS 49 BP 6840 EP 6844 DI 10.1016/j.vaccine.2009.09.016 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 524DM UT WOS:000272124000007 PM 19765398 ER PT J AU Wallace, RM Kammerer, JS Iademarco, MF Althomsons, SP Winston, CA Navin, TR AF Wallace, Ryan MacLaren Kammerer, J. Steve Iademarco, Michael F. Althomsons, Sandy P. Winston, Carla A. Navin, Thomas R. TI Increasing Proportions of Advanced Pulmonary Tuberculosis Reported in the United States Are Delays in Diagnosis on the Rise? SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE tuberculosis; smear positive; cavitation; low incidence; epidemiology ID INDUSTRIALIZED COUNTRIES; KNOWLEDGE; ELIMINATION; ATTITUDES; PATIENT; RUSSIA; TB AB Rationale: Delays in the diagnosis of tuberculosis (TB) can result in progression to advanced disease. Patients with pulmonary TB and advanced disease are more likely to transmit disease and fail treatment. Objectives: To examine clinical, epidemiological, and geographic factors associated with advanced pulmonary TB to further understanding of delayed diagnosis and transmission. Methods: Pulmonary tuberculosis cases in persons older than 15 years of age reported to the U.S. National Tuberculosis Surveillance System with advanced disease (cavitation on chest radiograph and acid-fast bacilli smear-positive sputum result) were compared with those without advanced disease using trend and binomial regression analysis. Measurements and Main Results: There were 35,584 cases of advanced pulmonary tuberculosis (APT) and 125,077 cases of non-APT reported from 1993 through 2006. Proportions of pulmonary TB cases with APT increased from 18.5% in 1993 to 26.1% in 2006, and the increase in the proportion of APT was most notable for national TB rates below 6.6 per 100,000. At the county level, the association between APT and low TB incidence has grown incrementally since 2000. The proportion of APT increased greatest among whites (65.4%), the employed (63.3%), and the U.S. born (59.2%). The prevalence of APT was 44% greater among persons with multidrug-resistant TB compared with those without it. Conclusions: This study highlights the need for TB diagnosis at early stages of the disease to minimize APT and decrease the risk of transmission. Additional efforts should concentrate on reducing time to treatment initiation in low-incidence areas and among groups traditionally seen as being at low risk for TB disease. C1 [Wallace, Ryan MacLaren; Winston, Carla A.; Navin, Thomas R.] Ctr Dis Control & Prevent, Div TB Eliminat, US Dept HHS, Atlanta, GA USA. [Kammerer, J. Steve; Althomsons, Sandy P.] Northrop Grumman, Atlanta, GA USA. [Iademarco, Michael F.] Commissioned Corps, US Publ Hlth Serv, US Dept HHS, Hanoi, Vietnam. RP Kammerer, JS (reprint author), 1600 Clifton Rd,NE MS E-10 Atlanta, Atlanta, GA 30333 USA. EM SKammerer@cdc.gov FU Department of Health and Human Services FX Funding for this study was provided by Department of Health and Human Services. NR 37 TC 21 Z9 21 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD NOV 15 PY 2009 VL 180 IS 10 BP 1016 EP 1022 DI 10.1164/rccm.200901-0059OC PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 519VR UT WOS:000271797600018 PM 19679694 ER PT J AU Girard, YA Travinsky, B Schotthoefer, A Fedorova, N Eisen, RJ Eisen, L Barbour, AG Lane, RS AF Girard, Yvette A. Travinsky, Bridgit Schotthoefer, Anna Fedorova, Natalia Eisen, Rebecca J. Eisen, Lars Barbour, Alan G. Lane, Robert S. TI Population Structure of the Lyme Borreliosis Spirochete Borrelia burgdorferi in the Western Black-Legged Tick (Ixodes pacificus) in Northern California SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID LIZARD SCELOPORUS-OCCIDENTALIS; FRAGMENT-LENGTH-POLYMORPHISM; OUTER-SURFACE PROTEIN; NORTHEASTERN UNITED-STATES; SENSU-STRICTO; DISEASE SPIROCHETE; GENETIC DIVERSITY; SEQUENCE ALIGNMENT; MENDOCINO COUNTY; DENSE WOODLANDS AB Factors potentially contributing to the lower incidence of Lyme borreliosis (LB) in the far-western than in the northeastern United States include tick host-seeking behavior resulting in fewer human tick encounters, lower densities of Borrelia burgdorferi-infected vector ticks in peridomestic environments, and genetic variation among B. burgdorferi spirochetes to which humans are exposed. We determined the population structure of B. burgdorferi in over 200 infected nymphs of the primary bridging vector to humans, Ixodes pacificus, collected in Mendocino County, CA. This was accomplished by sequence typing the spirochete lipoprotein ospC and the 16S-23S rRNA intergenic spacer (IGS). Thirteen ospC alleles belonging to 12 genotypes were found in California, and the two most abundant, ospC genotypes H3 and E3, have not been detected in ticks in the Northeast. The most prevalent ospC and IGS biallelic profile in the population, found in about 22% of ticks, was a new B. burgdorferi strain defined by ospC genotype H3. Eight of the most common ospC genotypes in the northeastern United States, including genotypes I and K that are associated with disseminated human infections, were absent in Mendocino County nymphs. ospC H3 was associated with hardwood-dominated habitats where western gray squirrels, the reservoir host, are commonly infected with LB spirochetes. The differences in B. burgdorferi population structure in California ticks compared to the Northeast emphasize the need for a greater understanding of the genetic diversity of spirochetes infecting California LB patients. C1 [Girard, Yvette A.; Fedorova, Natalia; Lane, Robert S.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Travinsky, Bridgit; Barbour, Alan G.] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA. [Travinsky, Bridgit; Barbour, Alan G.] Univ Calif Irvine, Dept Med, Irvine, CA 92697 USA. [Schotthoefer, Anna; Eisen, Rebecca J.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Ft Collins, CO 80522 USA. [Eisen, Lars] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. RP Girard, YA (reprint author), Univ Calif Berkeley, Dept Environm Sci Policy & Management, 137 Mulford Hall 3114, Berkeley, CA 94720 USA. EM yagirard@nature.berkeley.edu OI Barbour, Alan/0000-0002-0719-5248 FU National Institutes of Health [AI22501, AI24424]; patent royalties FX This work was supported by the National Institutes of Health grants AI22501 (R.S.L.) and AI24424 (A.G.B.) and by patent royalties (A.G.B.). NR 59 TC 25 Z9 26 U1 0 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD NOV 15 PY 2009 VL 75 IS 22 BP 7243 EP 7252 DI 10.1128/AEM.01704-09 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 516FG UT WOS:000271526800034 PM 19783741 ER PT J AU Pollack, LA Adamache, W Ryerson, AB Eheman, CR Richardson, LC AF Pollack, Lori A. Adamache, Walter Ryerson, A. Blythe Eheman, Christie R. Richardson, Lisa C. TI Care of Long-Term Cancer Survivors Physicians Seen by Medicare Enrollees Surviving Longer Than 5 Years SO CANCER LA English DT Article DE specialties; medical utilization; survivors; Surveillance; Epidemiology; and End Results program; Medicare; breast neoplasms; colorectal neoplasms; prostatic neoplasms; urinary bladder neoplasms; uterine neoplasms; aged ID BREAST-CANCER; COMORBIDITY INDEX; PREVENTIVE CARE; UNITED-STATES; FOLLOW-UP; SYSTEM; QUALITY AB BACKGROUND: Studies have shown that follow-up care for cancer patients differs by physician specialty, and that coordination between specialists and generalists results in better care. Little is known, however, regarding which specialties of physicians provide care to long-term cancer survivors. METHODS: The authors used Surveillance, Epidemiology, and End Results data from 1992 through 1997 that were linked to 1997-2003 Medicare data to identify persons diagnosed >5 years earlier with bladder, female breast, colorectal, prostate, or uterine cancer. Physician specialties were assigned by combining Medicare data with the American Medical Association Masterfile and the Unique Physician Identification Number Registry. The percentage of long-term survivors who visited physicians of interest was determined by analyzing Medicare outpatient claims submitted 6 to 12 years after initial diagnosis. RESULTS: Over the entire study period, 46% of female breast cancer survivors, 26% of colorectal cancer survivors, and 14% of prostate cancer survivors saw hematologists/oncologists. Radiation oncologists were seen by 11%, 2%, and 14% of breast, colorectal, and prostate cancer survivors, respectively. Survivors also sought care from specialists related to their cancer: 19% of breast cancer survivors had a cancer-coded visit with a surgeon, 26% of colorectal cancer survivors visited a gastroenterologist, and 68% of prostate cancer survivors visited a urologist. The percentage of survivors who visited cancer and cancer-related physicians declined each year. In contrast, nearly 75% of female breast, colorectal, and prostate cancer survivors saw primary care providers, and these percentages did not decrease annually. CONCLUSIONS: The findings of the current study underscore the need to include both primary care providers and cancer-related specialists in education and guidelines regarding cancer survivorship. Cancer 2009;115:5284-95. (C) 2009 American Cancer Society. C1 [Pollack, Lori A.; Ryerson, A. Blythe; Eheman, Christie R.; Richardson, Lisa C.] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Adamache, Walter] RTI Int, Waltham, MA USA. RP Pollack, LA (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, 4770 Buford Hwy NE,Mailstop K55, Atlanta, GA 30341 USA. EM lpollack@cdc.gov FU Centers for Disease Control and Prevention to RTI International [200-2002-00, 200-2002-575] FX Supported by contract 200-2002-00,575 from the Centers for Disease Control and Prevention to RTI International. NR 34 TC 29 Z9 29 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD NOV 15 PY 2009 VL 115 IS 22 BP 5284 EP 5295 DI 10.1002/cncr.24624 PG 12 WC Oncology SC Oncology GA 516SW UT WOS:000271564100022 PM 19685532 ER PT J AU Gould, LH Demma, L Jones, TF Hurd, S Vugia, DJ Smith, K Shiferaw, B Segler, S Palmer, A Zansky, S Griffin, PM AF Gould, L. Hannah Demma, Linda Jones, Timothy F. Hurd, Sharon Vugia, Duc J. Smith, Kirk Shiferaw, Beletshachew Segler, Suzanne Palmer, Amanda Zansky, Shelley Griffin, Patricia M. CA Emerging Infections Program TI Hemolytic Uremic Syndrome and Death in Persons with Escherichia coli O157:H7 Infection, Foodborne Diseases Active Surveillance Network Sites, 2000-2006 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID O157-H7 INFECTION; FOODNET SITES; UNITED-STATES; RISK-FACTORS; NEW-YORK; OUTBREAK; CHILDREN; CULTURE AB Background. Hemolytic uremic syndrome (HUS) is a life-threatening illness usually caused by infection with Shiga toxin-producing Escherichia coli O157 (STEC O157). We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS. Methods. STEC O157 infections and HUS cases were reported from 8 sites participating in the Foodborne Diseases Active Surveillance Network during 2000-2006. For each case of STEC O157 infection and HUS, demographic and clinical outcomes were reported. The proportion of STEC O157 infections resulting in HUS was determined. Results. A total of 3464 STEC O157 infections were ascertained; 218 persons (6.3%) developed HUS. The highest proportion of HUS cases (15.3%) occurred among children aged < 5 years. Death occurred in 0.6% of all patients with STEC O157 infection and in 4.6% of those with HUS. With or without HUS, persons aged >= 60 years had the highest rate of death due to STEC O157 infection. Twelve (3.1%) of 390 persons aged >= 60 years died, including 5 (33.3%) of 15 persons with HUS and 7 (1.9%) of 375 without. Among children aged < 5 years, death occurred in 4 (3.0%) of those with HUS and 2 (0.3%) of those without. Conclusions. Young children and females had an increased risk of HUS after STEC O157 infection. With or without HUS, elderly persons had the highest proportion of deaths associated with STEC O157 infection. These data support recommendations for aggressive supportive care of young children and the elderly early during illness due to STEC O157. C1 [Gould, L. Hannah; Demma, Linda; Griffin, Patricia M.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Segler, Suzanne] Georgia Emerging Infect Program, Atlanta, GA USA. [Jones, Timothy F.] Tennessee Dept Hlth, Nashville, TN USA. [Hurd, Sharon] Connecticut Emerging Infect Program, New Haven, CT USA. [Vugia, Duc J.] Calif Dept Publ Hlth, Richmond, CA USA. [Smith, Kirk] Minnesota Dept Hlth, St Paul, MN USA. [Shiferaw, Beletshachew] Oregon Dept Human Serv, Portland, OR USA. [Palmer, Amanda] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Zansky, Shelley] New York State Dept Hlth, Albany, NY USA. RP Gould, LH (reprint author), Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, 1600 Clifton Rd NE,MS F-22, Atlanta, GA 30333 USA. EM lgould@cdc.gov FU Centers for Disease Control and Prevention; United States Department of Agriculture; United States Food and Drug Administration FX The Centers for Disease Control and Prevention, the United States Department of Agriculture, and the United States Food and Drug Administration. The findings and conclusions in this report are those of the authors and do not necessarily represent those of the funding agencies. NR 22 TC 73 Z9 79 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2009 VL 49 IS 10 BP 1480 EP 1485 DI 10.1086/644621 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 511EH UT WOS:000271146200003 PM 19827953 ER PT J AU Dowell, D Polgreen, PM Beekmann, SE Workowski, KA Berman, SM Peterman, TA AF Dowell, Deborah Polgreen, Philip M. Beekmann, Susan E. Workowski, Kimberly A. Berman, Stuart M. Peterman, Thomas A. TI Dilemmas in the Management of Syphilis: A Survey of Infectious Diseases Experts SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID GENITAL ULCER DISEASE; CLINICAL-DIAGNOSIS; NEUROSYPHILIS; THERAPY; MEN AB We surveyed infectious diseases consultants to determine how they manage syphilis when there are insufficient data to guide management or when guidelines cannot be followed because of a lack of available definitive diagnostic tests. Most providers did not have access to dark-field microscopy. We found variation in management of syphilis, especially for patients with human immunodeficiency virus infection. C1 [Dowell, Deborah; Workowski, Kimberly A.; Berman, Stuart M.; Peterman, Thomas A.] Emory Univ, Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Atlanta, GA 30329 USA. [Dowell, Deborah] Emory Univ, Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA 30329 USA. [Workowski, Kimberly A.] Emory Univ, Dept Infect Dis, Atlanta, GA 30329 USA. [Polgreen, Philip M.; Beekmann, Susan E.] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA. RP Dowell, D (reprint author), Emory Univ, Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, 1600 Clifton Rd,NE,MS E-02, Atlanta, GA 30329 USA. EM gdo7@cdc.gov FU PHS HHS [U50 CCU112346] NR 14 TC 28 Z9 30 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2009 VL 49 IS 10 BP 1526 EP 1529 DI 10.1086/644737 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 511EH UT WOS:000271146200010 PM 19845476 ER PT J AU Deeks, SG Gange, SJ Kitahata, MM Saag, MS Justice, AC Hogg, RS Eron, JJ Brooks, JT Rourke, SB Gill, MJ Bosch, RJ Benson, CA Collier, AC Martin, JN Klein, MB Jacobson, LP Rodriguez, B Sterling, TR Kirk, GD Napravnik, S Rachlis, AR Calzavara, LM Horberg, MA Silverberg, MJ Gebo, KA Kushel, MB Goedert, JJ McKaig, RG Moore, RD AF Deeks, Steven G. Gange, Stephen J. Kitahata, Mari M. Saag, Michael S. Justice, Amy C. Hogg, Robert S. Eron, Joseph J. Brooks, John T. Rourke, Sean B. Gill, M. John Bosch, Ronald J. Benson, Constance A. Collier, Ann C. Martin, Jeffrey N. Klein, Marina B. Jacobson, Lisa P. Rodriguez, Benigno Sterling, Timothy R. Kirk, Gregory D. Napravnik, Sonia Rachlis, Anita R. Calzavara, Liviana M. Horberg, Michael A. Silverberg, Michael J. Gebo, Kelly A. Kushel, Margot B. Goedert, James J. McKaig, Rosemary G. Moore, Richard D. CA N Amer AIDS Cohort Collaboration R TI Trends in Multidrug Treatment Failure and Subsequent Mortality among Antiretroviral Therapy-Experienced Patients with HIV Infection in North America SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; VIROLOGICAL FAILURE; DRUG-RESISTANCE; HIV-1-INFECTED PATIENTS; RISK; COHORT; PROGRESSION; PREVALENCE; PREDICTORS; INHIBITORS AB Background. Although combination antiretroviral therapy continues to evolve, with potentially more effective options emerging each year, the ability of therapy to prevent multiple regimen failure and mortality in clinical practice remains poorly defined. Methods. Sixteen cohorts representing over 60 sites contributed data on all individuals who initiated combination antiretroviral therapy. We identified those individuals who experienced virologic failure (defined as a human immunodeficiency virus [HIV] RNA level 11000 copies/mL),received modified therapy, and subsequently had a second episode of virologic failure. Multivariate Cox regression was used to assess factors associated with time to second regimen failure and the time to death after the onset of second regimen failure. Results. Of the 42,790 individuals who received therapy, 7159 experienced a second virologic failure. The risk of second virologic failure decreased from 1996 (56 cases per 100 person-years) through 2005 (16 cases per 100 person-years; P < .001). The cumulative mortality after onset of second virologic failure was 26% at 5 years and decreased over time. A history of AIDS, a lower CD4(+) T cell count, and a higher plasma HIV RNA level were each independently associated with mortality. Similar trends were observed when analysis was limited to the subset of previously treatment-naive patients Conclusions. Although the rates of multiple regimen failure have decreased dramatically over the past decade, mortality rates for those who have experienced failure of at least 2 regimens have remained high. Plasma HIV RNA levels, CD4(+) T cell counts at time of treatment failure, and a history of AIDS remain independent risk factors for death, which emphasizes that these factors remain important targets for those in need of more-aggressive therapeutic interventions. C1 [Deeks, Steven G.; Martin, Jeffrey N.; Kushel, Margot B.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Benson, Constance A.] Univ Calif San Diego, San Diego, CA 92103 USA. [Horberg, Michael A.; Silverberg, Michael J.] Kaiser Permanente No Calif, Oakland, CA USA. [Gange, Stephen J.; Jacobson, Lisa P.; Kirk, Gregory D.; Gebo, Kelly A.; Moore, Richard D.] Johns Hopkins Univ, Baltimore, MD USA. [Goedert, James J.; McKaig, Rosemary G.] NIH, Bethesda, MD 20892 USA. [Kitahata, Mari M.; Collier, Ann C.] Univ Washington, Seattle, WA 98195 USA. [Saag, Michael S.] Univ Alabama, Birmingham, AL USA. [Justice, Amy C.] Yale Univ, New Haven, CT USA. [Eron, Joseph J.; Napravnik, Sonia] Univ N Carolina, Chapel Hill, NC USA. [Brooks, John T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bosch, Ronald J.] Harvard Univ, Boston, MA 02115 USA. [Rodriguez, Benigno] Case Western Reserve Univ, Cleveland, OH USA. [Sterling, Timothy R.] Vanderbilt Univ, Nashville, TN USA. [Hogg, Robert S.] Simon Fraser Univ, Vancouver, BC, Canada. [Rourke, Sean B.; Rachlis, Anita R.; Calzavara, Liviana M.] Univ Toronto, Toronto, ON, Canada. [Gill, M. John] Univ Calgary, Calgary, AB, Canada. [Klein, Marina B.] McGill Univ, Montreal, PQ, Canada. RP Deeks, SG (reprint author), San Francisco Gen Hosp, Ward 84,Bldg 80,995 Potrero Ave, San Francisco, CA 94110 USA. EM sdeeks@php.ucsf.edu RI Hogg, Robert/B-2783-2012; Rodriguez, Benigno/C-3365-2009; Gill, John/G-7083-2016; OI Rodriguez, Benigno/0000-0001-9736-7957; Gill, John/0000-0002-8546-8790; Gange, Stephen/0000-0001-7842-512X; Hogg, Robert/0000-0003-3463-5488 FU NCI NIH HHS [N02CP55504, Z01 CP010176]; NCRR NIH HHS [M01 RR000071, M01 RR000079, M01 RR000083, M01 RR000722, M01-RR00071, M01-RR00079, M01-RR00083]; NIAAA NIH HHS [R01 AA016893, R01-AA16893, U01 AA013566, U01-AA013566]; NIAID NIH HHS [AI-69432, K01 AI071754, K01-AI071754, K23-AI-61-0320, P30 AI027757, P30 AI027767, P30 AI050410, P30 AI054999, P30-AI27757, P30-AI27767, P30-AI50410, P30-AI54999, R24 AI067039, R24-AI067039, U01 AI031834, U01 AI034989, U01 AI034993, U01 AI034994, U01 AI035004, U01 AI035039, U01 AI035040, U01 AI035041, U01 AI035042, U01 AI035043, U01 AI037613, U01 AI037984, U01 AI038855, U01 AI038858, U01 AI042590, U01 AI068634, U01 AI068636, U01 AI069432, U01 AI069918, U01 AI069918-01, U01-AI069918, U01-AI31834, U01-AI34989, U01-AI34993, U01-AI34994, U01-AI35004, U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, U01-AI35043, U01-AI37613, U01-AI37984, U01-AI38855, U01-AI38858, U01-AI42590, U01-AI68634, U01-AI68636, UM1 AI069432]; NICHD NIH HHS [U01 HD032632, U01-HD32632]; NIDA NIH HHS [R01-DA11602, R01 DA004334, R01 DA011602, R01 DA012568, R01-DA04334, R01-DA12568, R56 DA004334]; NIMH NIH HHS [R01 MH054907, R01-MH54907]; PHS HHS [AHQ290-01-0012, K24-00432] NR 28 TC 28 Z9 28 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2009 VL 49 IS 10 BP 1582 EP 1590 DI 10.1086/644768 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 511EH UT WOS:000271146200021 PM 19845473 ER PT J AU Woods, C Palekar, R Kim, P Blythe, D de Senarclens, O Feldman, K Farnon, EC Rollin, PE Albarino, CG Nichol, ST Smith, M AF Woods, Christian Palekar, Rakhee Kim, Peter Blythe, David de Senarclens, Olivier Feldman, Katherine Farnon, Eileen C. Rollin, Pierre E. Albarino, Cesar G. Nichol, Stuart T. Smith, Margo TI Domestically Acquired Seoul Virus Causing Hemorrhagic Fever with Renal Syndrome-Maryland, 2008 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; HANTAVIRUS; BALTIMORE; RATS; PREVALENCE; PATHOGENS; ANTIBODY; USA AB Hantaviruses are rodent-borne viruses capable of causing human disease. The Seoul virus is a hantavirus that causes hemorrhagic fever with renal syndrome in East Asia. To our knowledge, we report the first domestically acquired case of hemorrhagic fever with renal syndrome caused by the Seoul virus, confirmed by serology testing, reverse-transcriptase polymerase chain reaction, and nucleotide sequence analysis. The patient presented with myalgias and fever, and developed acute renal failure. C1 [Woods, Christian] Washington Hosp Ctr, Dept Med, Sect Pulm Crit Care, Washington, DC 20010 USA. [Palekar, Rakhee; Blythe, David; Feldman, Katherine] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Palekar, Rakhee] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA. [Farnon, Eileen C.; Rollin, Pierre E.; Albarino, Cesar G.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Special Pathogens Branch, Atlanta, GA USA. RP Woods, C (reprint author), Washington Hosp Ctr, Dept Med, Sect Pulm Crit Care, Ste 2A-62,110 Irving St NW, Washington, DC 20010 USA. EM christian.woods@medstar.net NR 19 TC 12 Z9 12 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2009 VL 49 IS 10 BP E109 EP E112 DI 10.1086/644742 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 511EH UT WOS:000271146200033 PM 19848600 ER PT J AU Collarini, EJ Lee, FEH Foord, O Park, M Sperinde, G Wu, H Harriman, WD Carroll, SF Ellsworth, SL Anderson, LJ Tripp, RA Walsh, EE Keyt, BA Kauvar, LM AF Collarini, Ellen J. Lee, F. Eun-Hyung Foord, Orit Park, Minha Sperinde, Gizette Wu, Hai Harriman, William D. Carroll, Stephen F. Ellsworth, Stote L. Anderson, Larry J. Tripp, Ralph A. Walsh, Edward E. Keyt, Bruce A. Kauvar, Lawrence M. TI Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN MONOCLONAL-ANTIBODIES; SOLUBLE G-PROTEIN; G-GLYCOPROTEIN; NEUTRALIZING ANTIBODIES; PROTECTIVE IMMUNITY; RSV INFECTION; BALB/C MICE; PATHOGENESIS; CHILDREN; HOSPITALIZATION AB Native human Abs represent attractive drug candidates; however, the low frequency of B cells expressing high-quality Abs has posed a barrier to discovery. Using a novel single-cell phenotyping technology, we have overcome this barrier to discover human Abs targeting the conserved but poorly immunogenic central motif of respiratory syncytial virus (RSV) G protein. For the entire cohort of 24 subjects with recent RSV infection, B cells producing Abs meeting these stringent specificity criteria were rare, <10 per million. Several of the newly cloned Abs bind to the RSV G protein central conserved motif with very high affinity (K-d 1-24 pM). Two of the Abs were characterized in detail and compared with palivizumab, a humanized mAb against the RSV F protein. Relative to palivizumab, the anti-G Abs showed improved viral neutralization potency in vitro and enhanced reduction of infectious virus in a prophylaxis mouse model. Furthermore, in a mouse model for postinfection treatment, both anti-G Abs were significantly more effective than palivizumab at reducing viral load. The combination of activity in mouse models for both prophylaxis and treatment makes these high-affinity human-derived Abs promising candidates for human clinical testing. The Journal of Immunology, 2009, 183: 6338-6345. C1 [Collarini, Ellen J.; Foord, Orit; Park, Minha; Sperinde, Gizette; Wu, Hai; Harriman, William D.; Carroll, Stephen F.; Ellsworth, Stote L.; Keyt, Bruce A.; Kauvar, Lawrence M.] Trellis Biosci Inc, San Francisco, CA 94080 USA. [Lee, F. Eun-Hyung; Walsh, Edward E.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. [Anderson, Larry J.] Ctr Dis Control, Atlanta, GA 30333 USA. [Tripp, Ralph A.] Univ Georgia, Athens, GA 30602 USA. RP Kauvar, LM (reprint author), Trellis Biosci Inc, 2-B Corp Dr, San Francisco, CA 94080 USA. EM Lkauvar@trellisbio.com OI Tripp, Ralph/0000-0002-2924-9956 FU Trellis FX Trellis Bioscience employees all have equity interest. Collaborator Anderson at CDC has received significant grant support from Trellis. Other collaborators at University of Rochester and University of Georgia have received modest payments for unique reagents. NR 52 TC 38 Z9 38 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 2009 VL 183 IS 10 BP 6338 EP 6345 DI 10.4049/jimmunol.0901373 PG 8 WC Immunology SC Immunology GA 519KQ UT WOS:000271765700036 PM 19841167 ER PT J AU Taha, TE Kumwenda, J Cole, SR Hoover, DR Kafulafula, G Fowler, MG Thigpen, MC Li, Q Kumwenda, NI Mofenson, L AF Taha, Taha E. Kumwenda, Johnstone Cole, Stephen R. Hoover, Donald R. Kafulafula, George Fowler, Mary Glenn Thigpen, Michael C. Li, Qing Kumwenda, Newton I. Mofenson, Lynne TI Postnatal HIV-1 Transmission after Cessation of Infant Extended Antiretroviral Prophylaxis and Effect of Maternal Highly Active Antiretroviral Therapy SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID BREAST-MILK; INTERRUPTION; OUTCOMES; MOTHER; WOMEN; CHILD AB Background. The association between postnatal human immunodeficiency virus type 1 (HIV-1) transmission and maternal highly active antiretroviral therapy (HAART) after infant extended antiretroviral prophylaxis was assessed. Methods. A follow-up study was conducted for the Post-Exposure Prophylaxis of Infants trial in Blantyre, Malawi (PEPI-Malawi). In PEPI-Malawi, breast-feeding infants of HIV-infected women were randomized at birth to receive a either control regimen (single-dose nevirapine plus 1 week of zidovudine); the control regimen plus nevirapine to age 14 weeks; or the control regimen plus nevirapine and zidovudine to age 14 weeks. Infant HIV infection, maternal CD4 cell count, and HAART use were determined. Maternal HAART use was categorized as HAART eligible but untreated (CD4 cell count of <250 cells/mu L, no HAART received), HAART eligible and treated (CD4 cell count of <250 cells/mu L, HAART received), and HAART ineligible (CD4 cell count of >= 250 cells/mu L). The incidence of HIV infection and the association between postnatal HIV transmission and maternal HAART were calculated among infants who were HIV negative at 14 weeks. Results. Of 2318 infants, 130 (5.6%) acquired HIV infection, and 310 mothers (13.4%) received HAART. The rates of HIV transmission (in cases per 100 person-years) were as follows: for the HAART-eligible/untreated category, 10.56 (95% confidence interval [CI], 7.91-13.82); for the HAART-eligible/treated category, 1.79 (95% CI, 0.58-4.18); and for the HAART-ineligible category, 3.66 (95% CI, 2.86-4.61). The HIV transmission rate ratio for the HAART-eligible/treated category versus the HAART-eligible/untreated category, adjusted for infant prophylaxis, was 0.18 (95% CI, 0.07-0.44). Conclusions. Postnatal HIV transmission continues after cessation of infant prophylaxis. HAART-eligible women should start treatment early for their own health and to reduce postnatal HIV transmission to their infants. C1 [Taha, Taha E.; Li, Qing; Kumwenda, Newton I.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Fowler, Mary Glenn] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Mofenson, Lynne] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. [Cole, Stephen R.] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA. [Hoover, Donald R.] Rutgers State Univ, Piscataway, NJ USA. [Thigpen, Michael C.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Kumwenda, Johnstone; Kafulafula, George] Univ Malawi, Coll Med, Blantyre, Malawi. RP Taha, TE (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Rm E7138,615 N Wolfe St, Baltimore, MD 21205 USA. EM ttaha@jhsph.edu OI Mofenson, Lynne/0000-0002-2818-9808 NR 28 TC 45 Z9 47 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2009 VL 200 IS 10 BP 1490 EP 1497 DI 10.1086/644598 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 511EQ UT WOS:000271147100002 PM 19832114 ER PT J AU Ebrahim, SH Memish, ZA Uyeki, TM Khoja, TKAM Marano, N McNabb, SJN AF Ebrahim, Shahul H. Memish, Ziad A. Uyeki, Timothy M. Khoja, Tawfi K. A. M. Marano, Nina McNabb, Scott J. N. TI Pandemic H1N1 and the 2009 Hajj SO SCIENCE LA English DT Editorial Material ID RIFT-VALLEY FEVER; INFLUENZA-A H1N1; PNEUMONIA; PILGRIMS C1 [Ebrahim, Shahul H.; Uyeki, Timothy M.; Marano, Nina; McNabb, Scott J. N.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Memish, Ziad A.] Minist Hlth, Riyadh, Saudi Arabia. [Khoja, Tawfi K. A. M.] Council Gulf States, Hlth Minist Council Cooperat, Execut Board, Riyadh, Saudi Arabia. RP Ebrahim, SH (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM Sbe2@cdc.gov NR 24 TC 36 Z9 37 U1 0 U2 3 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 13 PY 2009 VL 326 IS 5955 BP 938 EP 940 DI 10.1126/science.1183210 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 518SB UT WOS:000271712300018 PM 19933105 ER PT J AU Jain, S Kamimoto, L Bramley, AM Schmitz, AM Benoit, SR Louie, J Sugerman, DE Druckenmiller, JK Ritger, KA Chugh, R Jasuja, S Deutscher, M Chen, S Walker, JD Duchin, JS Lett, S Soliva, S Wells, EV Swerdlow, D Uyeki, TM Fiore, AE Olsen, SJ Fry, AM Bridges, CB Finelli, L AF Jain, Seema Kamimoto, Laurie Bramley, Anna M. Schmitz, Ann M. Benoit, Stephen R. Louie, Janice Sugerman, David E. Druckenmiller, Jean K. Ritger, Kathleen A. Chugh, Rashmi Jasuja, Supriya Deutscher, Meredith Chen, Sanny Walker, John D. Duchin, Jeffrey S. Lett, Susan Soliva, Susan Wells, Eden V. Swerdlow, David Uyeki, Timothy M. Fiore, Anthony E. Olsen, Sonja J. Fry, Alicia M. Bridges, Carolyn B. Finelli, Lyn CA 2009 Pandemic Influenza H1N1 Virus TI Hospitalized Patients with 2009 H1N1 Influenza in the United States, April-June 2009. SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID PREGNANT-WOMEN; VIRUS-INFECTION; CHILDREN; COMPLICATIONS; SURVEILLANCE; ADMISSIONS; CALIFORNIA; MORTALITY; VACCINES; HUMANS AB Background: During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. We describe the clinical characteristics of patients who were hospitalized with 2009 H1N1 influenza in the United States from April 2009 to mid-June 2009. Methods: Using medical charts, we collected data on 272 patients who were hospitalized for at least 24 hours for influenza-like illness and who tested positive for the 2009 H1N1 virus with the use of a real-time reverse-transcriptase-polymerase-chain-reaction assay. Results: Of the 272 patients we studied, 25% were admitted to an intensive care unit and 7% died. Forty-five percent of the patients were children under the age of 18 years, and 5% were 65 years of age or older. Seventy-three percent of the patients had at least one underlying medical condition; these conditions included asthma; diabetes; heart, lung, and neurologic diseases; and pregnancy. Of the 249 patients who underwent chest radiography on admission, 100 (40%) had findings consistent with pneumonia. Of the 268 patients for whom data were available regarding the use of antiviral drugs, such therapy was initiated in 200 patients (75%) at a median of 3 days after the onset of illness. Data suggest that the use of antiviral drugs was beneficial in hospitalized patients, especially when such therapy was initiated early. Conclusions: During the evaluation period, 2009 H1N1 influenza caused severe illness requiring hospitalization, including pneumonia and death. Nearly three quarters of the patients had one or more underlying medical conditions. Few severe illnesses were reported among persons 65 years of age or older. Patients seemed to benefit from antiviral therapy. N Engl J Med 2009;361:1935-44. C1 [Jain, Seema; Kamimoto, Laurie; Bramley, Anna M.; Sugerman, David E.; Uyeki, Timothy M.; Fiore, Anthony E.; Olsen, Sonja J.; Fry, Alicia M.; Bridges, Carolyn B.; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Schmitz, Ann M.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Benoit, Stephen R.] Ctr Dis Control & Prevent, Div Emergency Preparedness & Response, Natl Ctr Publ Hlth Informat, Atlanta, GA 30333 USA. [Deutscher, Meredith; Chen, Sanny; Swerdlow, David] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Deutscher, Meredith] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Louie, Janice] Calif Dept Publ Hlth, Richmond, CA USA. [Swerdlow, David] San Diego Cty Hlth & Human Serv, San Diego, CA USA. [Druckenmiller, Jean K.] Wisconsin Div Publ Hlth, Madison, WI USA. [Ritger, Kathleen A.] Chicago Dept Publ Hlth, Chicago, IL USA. [Chugh, Rashmi] DuPage Cty Hlth Dept, Wheaton, IL USA. [Jasuja, Supriya] Cook Cty Dept Publ Hlth, Oak Pk, IL USA. [Chen, Sanny] Arizona Dept Publ Hlth, Phoenix, AZ USA. [Walker, John D.] Texas Dept State Hlth Serv, Austin, TX USA. [Duchin, Jeffrey S.] Publ Health Seattle & King Cty, Seattle, WA USA. [Lett, Susan; Soliva, Susan] Massachusetts Dept Hlth, Jamaica Plain, MA USA. [Wells, Eden V.] Michigan Dept Community Hlth, Lansing, MI USA. RP Jain, S (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM bwc8@cdc.gov OI Meites, Elissa/0000-0002-0077-2591 FU Influenza Division; Office of Workforce and Career Development FX Supported by the Influenza Division and Office of Workforce and Career Development at the CDC. NR 34 TC 995 Z9 1077 U1 10 U2 92 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 12 PY 2009 VL 361 IS 20 BP 1935 EP 1944 DI 10.1056/NEJMoa0906695 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 518AI UT WOS:000271660500007 PM 19815859 ER PT J AU Hancock, K Veguilla, V Lu, XH Zhong, WM Butler, EN Sun, H Liu, F Dong, LB DeVos, JR Gargiullo, PM Brammer, TL Cox, NJ Tumpey, TM Katz, JM AF Hancock, Kathy Veguilla, Vic Lu, Xiuhua Zhong, Weimin Butler, Ebonee N. Sun, Hong Liu, Feng Dong, Libo DeVos, Joshua R. Gargiullo, Paul M. Brammer, T. Lynnette Cox, Nancy J. Tumpey, Terrence M. Katz, Jacqueline M. TI Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus. SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID NEUTRALIZING ANTIBODIES; VACCINE; IMMUNITY; HUMANS; ORIGIN; H5N1; VOLUNTEERS; INFECTION; SERUM; AGE AB Background: A new pandemic influenza A (H1N1) virus has emerged, causing illness globally, primarily in younger age groups. To assess the level of preexisting immunity in humans and to evaluate seasonal vaccine strategies, we measured the antibody response to the pandemic virus resulting from previous influenza infection or vaccination in different age groups. Methods: Using a microneutralization assay, we measured cross-reactive antibodies to pandemic H1N1 virus (2009 H1N1) in stored serum samples from persons who either donated blood or were vaccinated with recent seasonal or 1976 swine influenza vaccines. Results: A total of 4 of 107 persons (4%) who were born after 1980 had preexisting cross-reactive antibody titers of 40 or more against 2009 H1N1, whereas 39 of 115 persons (34%) born before 1950 had titers of 80 or more. Vaccination with seasonal trivalent inactivated influenza vaccines resulted in an increase in the level of cross-reactive antibody to 2009 H1N1 by a factor of four or more in none of 55 children between the ages of 6 months and 9 years, in 12 to 22% of 231 adults between the ages of 18 and 64 years, and in 5% or less of 113 adults 60 years of age or older. Seasonal vaccines that were formulated with adjuvant did not further enhance cross-reactive antibody responses. Vaccination with the A/New Jersey/1976 swine influenza vaccine substantially boosted cross-reactive antibodies to 2009 H1N1 in adults. Conclusions: Vaccination with recent seasonal nonadjuvanted or adjuvanted influenza vaccines induced little or no cross-reactive antibody response to 2009 H1N1 in any age group. Persons under the age of 30 years had little evidence of cross-reactive antibodies to the pandemic virus. However, a proportion of older adults had preexisting cross-reactive antibodies. N Engl J Med 2009;361:1945-52. C1 [DeVos, Joshua R.] Ctr Dis Control & Prevent, Div Global AIDS, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Hancock, Kathy; Veguilla, Vic; Lu, Xiuhua; Zhong, Weimin; Butler, Ebonee N.; Sun, Hong; Liu, Feng; Dong, Libo; Gargiullo, Paul M.; Brammer, T. Lynnette; Cox, Nancy J.; Tumpey, Terrence M.; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Katz, JM (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM jkatz@cdc.gov FU GlaxoSmithKline; Juvaris BioTherapeutics FX Dr. Hancock reports receiving research support from GlaxoSmithKline and Juvaris BioTherapeutics; Dr. Lu, research support from Juvaris BioTherapeutics; and Dr. Katz, research support from GlaxoSmithKline. No other conflict of interest relevant to this article was reported. NR 29 TC 824 Z9 860 U1 4 U2 65 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 12 PY 2009 VL 361 IS 20 BP 1945 EP 1952 DI 10.1056/NEJMoa0906453 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 518AI UT WOS:000271660500008 PM 19745214 ER PT J AU Nieto, PD Boughton, R Dorn, PL Steurer, F Raychaudhuri, S Esfandiari, J Goncalves, E Diaz, J Malone, JB AF Nieto, Prixia D. Boughton, Roger Dorn, Patricia L. Steurer, Frank Raychaudhuri, Syamal Esfandiari, Javan Goncalves, Edson Diaz, James Malone, John B. TI Comparison of two immunochromatographic assays and the indirect immunofluorscence antibody test for diagnosis of Trypanosoma cruzi infection in dogs in south central Louisiana SO VETERINARY PARASITOLOGY LA English DT Article DE Chagas in dogs; Trypanosoma cruzi; Diagnosis; Zoonotic disease; American trypanosomiasis ID POLYMERASE-CHAIN-REACTION; CHAGAS-DISEASE; AMERICAN TRYPANOSOMIASIS; ARGENTINA; TEXAS; BLOOD; CHACO; XENODIAGNOSIS; PREVALENCE; RESERVOIR AB Two rapid tests evaluated in dogs considered to be of high risk of Infection with the Chagas parasite Trypanosoma cruzi using two immunochromatographic assays. Trypanosoma Detect (TM) for canine, InBios, Seattle, WA and CHAGAS STAT-PAK (TM) assay, Chembio Diagnostic Systems, Medford, NY, in south central Louisiana. For this purpose a serological survey was carried out in a total of 122 dogs and a serum bank was created. These 122 animals were first tested by IFAT that was used as the standard test From the serum bank 50 samples were tested using the two rapid Chagas assays and results compared to the standard test IFAT The serological survey using IFAT showed it prevalence of T cruzi infection in 22.1% of the tested dogs. In the immunochromatographic assays. 13 and 11 animals were positive on rapid assay Trypanosoma Detect (TM) for canine, InBios and CHAGAS STAT-PAK (TM), Chembio Diagnostic Systems, respectively compared to 11 positive by IFAT. These two immunochromatographic tests have shown high susceptibility and specificity compared to our standard method IFAT. The rapid, easy and accurate screening assays used in conjunction with confirmatory tests, would be an excellent tool for veterinarians to diagnose T cruzi infection. Early detection of T cruzi infection may prevent complications through an effective treatment. Greater awareness by veterinarians of the risk. clinical findings, history along with diagnostic methods will contribute greatly to an understanding of the true prevalence of Chagas disease in dogs in Louisiana. (c) 2009 Elsevier B.V. All rights reserved. C1 [Nieto, Prixia D.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA. [Boughton, Roger] Iberia Anim Clin, New Iberia, LA USA. [Dorn, Patricia L.] Loyola Univ, New Orleans, LA 70118 USA. [Steurer, Frank] CDC, Chamblee, GA USA. [Raychaudhuri, Syamal] InBios, Seattle, WA USA. [Esfandiari, Javan] Chembio Diagnost Syst, Medford, MA USA. [Goncalves, Edson] Univ Estadual Paulista, Sao Paulo, Brazil. [Diaz, James] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. RP Nieto, PD (reprint author), Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Room 3328,Skip Bertman Dr,S Stadium Rd, Baton Rouge, LA 70803 USA. OI Dorn, Patricia/0000-0001-8555-7008 NR 41 TC 18 Z9 18 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 J9 VET PARASITOL JI Vet. Parasitol. PD NOV 12 PY 2009 VL 165 IS 3-4 BP 241 EP 247 DI 10.1016/j.vetpar.2009.07.010 PG 7 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA 516LJ UT WOS:000271543400006 PM 19647943 ER PT J AU Ahluwalia, IB Harrison, L Jamieson, D Rasmussen, SA AF Ahluwalia, I. B. Harrison, L. Jamieson, D. Rasmussen, S. A. TI Receipt of Influenza Vaccine During Pregnancy Among Women With Live Births-Georgia and Rhode Island, 2004-2007 (Reprinted from MMWR, vol 58, pg 972-975, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Ahluwalia, I. B.; Harrison, L.; Jamieson, D.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. [Rasmussen, S. A.] CDC, Div Birth Defects Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Ahluwalia, IB (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 11 PY 2009 VL 302 IS 18 BP 1964 EP 1966 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 517MY UT WOS:000271619700011 ER PT J AU Presson, AP Sobel, EM Papp, JC Suarez, CJ Whistler, T Rajeevan, MS Vernon, SD Horvath, S AF Presson, Angela P. Sobel, Eric M. Papp, Jeanette C. Suarez, Charlyn J. Whistler, Toni Rajeevan, Mangalathu S. Vernon, Suzanne D. Horvath, Steve TI Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome SO BMC SYSTEMS BIOLOGY LA English DT Article ID MENDELIAN RANDOMIZATION; HPA AXIS; EXPRESSION; DISEASE; POLYMORPHISMS; POPULATION; MOUSE; ENCEPHALOMYOPATHY; ENCEPHALOMYELITIS; IMMUNODEFICIENCY AB Background: Systems biologic approaches such as Weighted Gene Co-expression Network Analysis (WGCNA) can effectively integrate gene expression and trait data to identify pathways and candidate biomarkers. Here we show that the additional inclusion of genetic marker data allows one to characterize network relationships as causal or reactive in a chronic fatigue syndrome (CFS) data set. Results: We combine WGCNA with genetic marker data to identify a disease-related pathway and its causal drivers, an analysis which we refer to as "Integrated WGCNA" or IWGCNA. Specifically, we present the following IWGCNA approach: 1) construct a co-expression network, 2) identify trait-related modules within the network, 3) use a trait-related genetic marker to prioritize genes within the module, 4) apply an integrated gene screening strategy to identify candidate genes and 5) carry out causality testing to verify and/or prioritize results. By applying this strategy to a CFS data set consisting of microarray, SNP and clinical trait data, we identify a module of 299 highly correlated genes that is associated with CFS severity. Our integrated gene screening strategy results in 20 candidate genes. We show that our approach yields biologically interesting genes that function in the same pathway and are causal drivers for their parent module. We use a separate data set to replicate findings and use Ingenuity Pathways Analysis software to functionally annotate the candidate gene pathways. Conclusion: We show how WGCNA can be combined with genetic marker data to identify disease-related pathways and the causal drivers within them. The systems genetics approach described here can easily be used to generate testable genetic hypotheses in other complex disease studies. C1 [Presson, Angela P.; Sobel, Eric M.; Papp, Jeanette C.; Suarez, Charlyn J.; Horvath, Steve] Univ Calif Los Angeles, Los Angeles, CA 90024 USA. [Whistler, Toni; Rajeevan, Mangalathu S.; Vernon, Suzanne D.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Vernon, Suzanne D.] CFIDS, Charlotte, NC USA. RP Horvath, S (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90024 USA. EM apresson@ucla.edu; esobel@mednet.ucla.edu; jcpapp@mednet.ucla.ed; charlynsuarez@yahoo.com; taw6@cdc.gov; mor4@cdc.gov; sdv2@cdc.gov; shorvath@mednet.ucla.edu RI Whistler, Toni/A-6709-2009 FU USPHS [U19 AI063603, T32 HG002536, P50CA092131, HL28481, CA16042] FX This work was supported in part by USPHS grants U19 AI063603 (SH), T32 HG002536 (APP), P50CA092131 (SH), HL28481 (SH) and CA16042 (SH). NR 70 TC 59 Z9 61 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD NOV 6 PY 2009 VL 2 AR 95 DI 10.1186/1752-0509-2-95 PG 21 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 407CG UT WOS:000263340600001 PM 18986552 ER PT J AU Budnitz, DS Lewis, LL Shehab, N Birnkrant, D AF Budnitz, Daniel S. Lewis, Linda L. Shehab, Nadine Birnkrant, Debra TI Risk of Confusion in Dosing Tamiflu Oral Suspension in Children SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Budnitz, Daniel S.; Shehab, Nadine] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Lewis, Linda L.; Birnkrant, Debra] US FDA, Rockville, MD 20857 USA. RP Budnitz, DS (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM dbudnitz@cdc.gov NR 5 TC 1 Z9 2 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 5 PY 2009 VL 361 IS 19 BP 1913 EP 1914 DI 10.1056/NEJMc0909190 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 514OZ UT WOS:000271405800031 PM 19797275 ER PT J AU Ray, GT Pelton, SI Klugman, KP Strutton, DR Moore, MR AF Ray, G. Thomas Pelton, Stephen I. Klugman, Keith P. Strutton, David R. Moore, Matthew R. TI Cost-effectiveness of pneumococcal conjugate vaccine: An update after 7 years of use in the United States SO VACCINE LA English DT Article DE Pneumococcal conjugate vaccine; Pneumococcus; Vaccine; Cost; Herd immunity ID ACUTE OTITIS-MEDIA; COMMUNITY-ACQUIRED PNEUMONIA; HEALTH-CARE UTILIZATION; STREPTOCOCCUS-PNEUMONIAE; YOUNG-CHILDREN; CHILDHOOD IMMUNIZATION; CHANGING EPIDEMIOLOGY; IMPACT; POPULATION; SEROTYPES AB Seven-valent pneumococcal conjugate vaccine (PCV7) has been in routine use in the United States since 2000 and data have indicated direct and indirect effects of the vaccine. We simulated the effects of PCV7 on children vaccinated during 2000-2006, incorporating direct and indirect effects on incidence of invasive pneumococcal disease (IPD), hospitalized pneumonia and otitis media. Before accounting for indirect effects, PCV7 cost $201,000 per life-year saved. After incorporating indirect effects on IPD, cost per life-year saved was $10,400. The presence of modest additional indirect effects against hospitalized pneumonia and otitis media in children may have resulted in overall cost savings. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Ray, G. Thomas] Kaiser Permanente Med Care Program No Calif Reg, Div Res, Oakland, CA 94612 USA. [Pelton, Stephen I.] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA. [Klugman, Keith P.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Klugman, Keith P.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Strutton, David R.] Wyeth Ayerst Res, Philadelphia, PA USA. [Moore, Matthew R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Ray, GT (reprint author), Kaiser Permanente Med Care Program No Calif Reg, Div Res, 2000 Broadway, Oakland, CA 94612 USA. EM tom.ray@kp.org OI Pelton, Stephen/0000-0003-4862-5344 FU Wyeth Pharmaceuticals FX We would like to thank the investigators of the Centers For Disease Control and Prevention's Active Bacterial Core surveillance program for the use of their data, and Elizabeth Zell for calculating IPD disease rates. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. This study was funded, in part, by Wyeth Pharmaceuticals, which provided research support for G. Thomas Ray. Keith P. Klugman and Stephen I. Pelton have received research funds and consulting fees from Wyeth Pharmaceuticals. NR 53 TC 36 Z9 37 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 IS 47 BP 6483 EP 6494 DI 10.1016/j.vaccine.2009.08.045 PG 12 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 523FA UT WOS:000272056300001 PM 19720366 ER PT J AU Price, GE Soboleski, MR Lo, CY Misplon, JA Pappas, C Houser, KV Tumpey, TM Epstein, SL AF Price, Graeme E. Soboleski, Mark R. Lo, Chia-Yun Misplon, Julia A. Pappas, Claudia Houser, Katherine V. Tumpey, Terrence M. Epstein, Suzanne L. TI Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses SO VACCINE LA English DT Article DE Influenza; Immunization; Heterosubtypic immunity; DNA vaccine; Prime-boost; Recombinant adenovirus; Cold-adapted; H5N1; Pandemic; Vaccine; Ferret; Mice; Intranasal; Systemic; Intramuscular ID CD8(+) T-CELLS; MATRIX PROTEIN-2; IN-VIVO; HETEROSUBTYPIC IMMUNITY; SELECTIVE EXPRESSION; MONOCLONAL-ANTIBODY; DNA VACCINES; M2 PROTEIN; MEMORY; RESPONSES AB Immunization against conserved virus components induces broad, heterosubtypic protection against diverse influenza A viruses, providing a strategy for controlling unexpected outbreaks or pandemics until strain-matched vaccines become available. This study characterized immunization to nucleoprotein (NP) and matrix 2 (M2) by DNA priming followed by parenteral or mucosal boosting in mice and ferrets. DNA vaccination followed by boosting with antigen-matched recombinant adenovirus (rAd) or cold-adapted (ca) influenza virus provided robust protection against virulent H1N1 and H5N1 challenges. Compared to other boosts, mucosal rAd induced stronger IgA responses, more virus-specific activated T-cells in the lung, and better protection against morbidity following challenge even eight months post-boost. In ferrets, both mucosal and parenteral rAd boosting protected from lethal H5N1 challenge. These findings demonstrate potent protection by vaccination highly focused on conserved antigens and identify immune response measures in mice that differed among vaccinations and correlated with outcome. Published by Elsevier Ltd. C1 [Price, Graeme E.; Soboleski, Mark R.; Lo, Chia-Yun; Misplon, Julia A.; Epstein, Suzanne L.] US FDA, Ctr Biol Evaluat & Res, Div Cellular & Gene Therapies, Rockville, MD 20852 USA. [Pappas, Claudia; Houser, Katherine V.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Epstein, SL (reprint author), US FDA, Ctr Biol Evaluat & Res, Div Cellular & Gene Therapies, Rockville, MD 20852 USA. EM suzanne.epstein@fda.hhs.gov FU FDA; National Vaccine Program Office; Office of Public Health Emergency Medical Countermeasures; CBER Pandemic Influenza Initiative FX This work is funded by FDA, the National Vaccine Program Office, the Office of Public Health Emergency Medical Countermeasures, and the CBER Pandemic Influenza Initiative. NR 48 TC 79 Z9 82 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 IS 47 BP 6512 EP 6521 DI 10.1016/j.vaccine.2009.08.053 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 523FA UT WOS:000272056300004 PM 19729082 ER PT J AU Irving, SA Donahue, JG Shay, DK Ellis-Coyle, TL Belongia, EA AF Irving, Stephanie A. Donahue, James G. Shay, David K. Ellis-Coyle, Tina L. Belongia, Edward A. TI Evaluation of self-reported and registry-based influenza vaccination status in a Wisconsin cohort SO VACCINE LA English DT Article DE Influenza vaccine; Vaccine registry; Self-reported vaccination status ID ELDERLY OUTPATIENTS; VALIDATION; CHILDREN; IMMUNIZATION; MARSHFIELD; SEASON AB We evaluated influenza vaccination status as determined by self-report and a regional, real-time immunization registry during two influenza seasons when subjects were enrolled in a study to estimate vaccine effectiveness. We enrolled 2907 patients during the two consecutive seasons. The sensitivity and specificity of self-reported influenza vaccination when compared to immunization registry records were 95% and 90%, respectively. The positive predictive value of self-reported vaccination was 89% and negative predictive value was 96%. In our study population, self-reported influenza vaccine status was a sensitive and fairly specific indicator of actual vaccine status. Misclassification was more common among young children. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Irving, Stephanie A.] Marshfield Clin Res Fdn, Epidemiol Res Ctr, Marshfield, WI 54449 USA. [Shay, David K.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Irving, SA (reprint author), Marshfield Clin Res Fdn, Epidemiol Res Ctr, 1000 N Oak Ave,ML2, Marshfield, WI 54449 USA. EM irving.stephanie@marshfieldclinic.org OI Irving, Stephanie/0000-0001-7437-6797; Shay, David/0000-0001-9619-4820 FU Centers for Disease Control and Prevention [1 U01 C1000192-01] FX We thank Craig Becker, Lorelle Benetti and Debra Kempf for their assistance with this project. Funding for this research was provided by a cooperative agreement with the Centers for Disease Control and Prevention (1 U01 C1000192-01). NR 19 TC 62 Z9 62 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 5 PY 2009 VL 27 IS 47 BP 6546 EP 6549 DI 10.1016/j.vaccine.2009.08.050 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 523FA UT WOS:000272056300008 PM 19729083 ER PT J AU Louie, J Jean, C Chen, TH Park, S Ueki, R Harper, T Chmara, E Myers, J Stoppacher, R Catanese, C Farley, N Leis, E DiAngelo, C Fry, AM Finelli, L Carvalho, MG Beall, B Moore, M Whitney, C Blau, DM AF Louie, J. Jean, C. Chen, T-H Park, S. Ueki, R. Harper, T. Chmara, E. Myers, J. Stoppacher, R. Catanese, C. Farley, N. Leis, E. DiAngelo, C. Fry, A. M. Finelli, L. Carvalho, M. G. Beall, B. Moore, M. Whitney, C. Blau, D. M. TI Bacterial Coinfections in Lung Tissue Specimens From Fatal Cases of 2009 Pandemic Influenza A (H1N1)-United States, May-August 2009 (Reprinted from MMWR, vol 58, pg 1071-1074, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Chen, T-H; Park, S.; Ueki, R.] Hawaii State Dept Hlth, Honolulu, HI USA. [Harper, T.] ChicagoDept Publ Hlth, Chicago, IL USA. [Catanese, C.] City New York Off Chief Med Examiner, New York, NY USA. [Catanese, C.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Catanese, C.] New York State Dept Hlth, Albany, NY 12237 USA. [Blau, D. M.] CDC, Atlanta, GA 30333 USA. NR 1 TC 4 Z9 4 U1 2 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 4 PY 2009 VL 302 IS 17 BP 1852 EP + PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 514DU UT WOS:000271375300005 ER PT J AU Shannon, S Louie, J Siniscalchi, A Rico, E Richter, D Hernandez, R Lynfield, R McHugh, L Waters, C Lee, E Stoute, A Landers, K Bandy, U Pascoe, N Vernon, V Haupt, T Moore, C Schieve, L Peacock, G Boyle, C Honein, M Yeargin-Allsopp, M Trevathan, E Finelli, L Uyeki, T Dhara, R Fowlkes, A Christensen, D Jarquin, V AF Shannon, S. Louie, J. Siniscalchi, A. Rico, E. Richter, D. Hernandez, R. Lynfield, R. McHugh, L. Waters, C. Lee, E. Stoute, A. Landers, K. Bandy, U. Pascoe, N. Vernon, V. Haupt, T. Moore, C. Schieve, L. Peacock, G. Boyle, C. Honein, M. Yeargin-Allsopp, M. Trevathan, E. Finelli, L. Uyeki, T. Dhara, R. Fowlkes, A. Christensen, D. Jarquin, V. TI Surveillance for Pediatric Deaths Associated With 2009 Pandemic Influenza A (H1N1)-Virus Infection United States, April-August 2009 (Reprinted from MMWR, vol 58, pg 941-947, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID CHILDREN C1 [Shannon, S.] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Rico, E.] Miami Dade Cty Hlth Dept, Miami, FL USA. [Richter, D.] Illinois Dept Publ Hlth, Springfield, IL 62761 USA. [Hernandez, R.] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA. [Lynfield, R.] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Waters, C.] New York State Dept Hlth, Albany, NY 12237 USA. [Lee, E.; Stoute, A.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Bandy, U.] Rhode Isl Dept Hlth, Providence, RI 02908 USA. [Vernon, V.] Utah Dept Hlth, Salt Lake City, UT 84116 USA. [Haupt, T.] Wisconsin Dept Hlth Svcs, Madison, WI USA. [Christensen, D.; Jarquin, V.] CDC, Atlanta, GA 30333 USA. RP Shannon, S (reprint author), Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. NR 9 TC 2 Z9 2 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 4 PY 2009 VL 302 IS 17 BP 1855 EP 1857 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 514DU UT WOS:000271375300006 ER PT J AU Srinivasan, A Perl, TM AF Srinivasan, Arjun Perl, Trish M. TI Respiratory Protection Against Influenza SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID HEALTH-CARE WORKERS; INFECTION; VIRUS; TRANSMISSION; EFFICACY; VACCINE; FILTER C1 [Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Perl, Trish M.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Perl, Trish M.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Srinivasan, A (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A35, Atlanta, GA 30333 USA. EM beu8@cdc.gov NR 15 TC 13 Z9 14 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 4 PY 2009 VL 302 IS 17 BP 1903 EP 1904 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 514DU UT WOS:000271375300022 PM 19797473 ER PT J AU Gerberding, JL AF Gerberding, Julie Louise TI Influenza in 2009 New Solutions, Same Old Problems SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID TRANSMISSION; VIRUSES C1 [Gerberding, Julie Louise] Ctr Dis Control & Prevent, Atlanta, GA 30833 USA. RP Gerberding, JL (reprint author), Ste 22-188,2484 Briarcliff Rd, Atlanta, GA 30329 USA. EM JulieGerberdingMD.LLC@gmail.com NR 17 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 4 PY 2009 VL 302 IS 17 BP 1907 EP 1908 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 514DU UT WOS:000271375300024 PM 19887666 ER PT J AU Aljofan, M Sganga, ML Lo, MK Rootes, CL Porotto, M Meyer, AG Saubern, S Moscona, A Mungall, BA AF Aljofan, Mohamad Sganga, Michael L. Lo, Michael K. Rootes, Christina L. Porotto, Matteo Meyer, Adam G. Saubern, Simon Moscona, Anne Mungall, Bruce A. TI Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro SO VIROLOGY JOURNAL LA English DT Article ID TO-PERSON TRANSMISSION; MALACHITE GREEN; CATIONIC DYES; FATAL ENCEPHALITIS; TRYPANOSOMA-CRUZI; PROTEIN-SYNTHESIS; RECEPTOR-BINDING; CRYSTAL-VIOLET; RAINBOW-TROUT; HAMSTER MODEL AB Background: Using a recently described monolayer assay amenable to high throughput screening format for the identification of potential Nipah virus and Hendra virus antivirals, we have partially screened a low molecular weight compound library (>8,000 compounds) directly against live virus infection and identified twenty eight promising lead molecules. Initial single blind screens were conducted with 10 mu M compound in triplicate with a minimum efficacy of 90% required for lead selection. Lead compounds were then further characterised to determine the median efficacy (IC(50)), cytotoxicity (CC(50)) and the in vitro therapeutic index in live virus and pseudotype assay formats. Results: While a number of leads were identified, the current work describes three commercially available compounds: brilliant green, gentian violet and gliotoxin, identified as having potent antiviral activity against Nipah and Hendra virus. Similar efficacy was observed against pseudotyped Nipah and Hendra virus, vesicular stomatitis virus and human parainfluenza virus type 3 while only gliotoxin inhibited an influenza A virus suggesting a non-specific, broad spectrum activity for this compound. Conclusion: All three of these compounds have been used previously for various aspects of antibacterial and anti-fungal therapy and the current results suggest that while unsuitable for internal administration, they may be amenable to topical antiviral applications, or as disinfectants and provide excellent positive controls for future studies. C1 [Aljofan, Mohamad; Rootes, Christina L.; Mungall, Bruce A.] CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic, Australia. [Sganga, Michael L.; Porotto, Matteo; Moscona, Anne; Mungall, Bruce A.] Cornell Univ, Weill Med Coll, Dept Pediat, New York, NY 10021 USA. [Sganga, Michael L.; Porotto, Matteo; Moscona, Anne; Mungall, Bruce A.] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA. [Lo, Michael K.] Ctr Dis Control & Prevent, Measles Mumps Rubella & Herpes Virus Lab Branch, Div Viral Dis, Atlanta, GA USA. [Aljofan, Mohamad] Univ Queensland, Sch Vet Sci, St Lucia, Qld, Australia. [Meyer, Adam G.; Saubern, Simon] CSIRO Mol & Hlth Technol, Clayton, Vic, Australia. RP Mungall, BA (reprint author), CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic, Australia. EM Mohamad.Aljofan@csiro.au; michaelsganga@gmail.com; mko2@cdc.gov; Chris.Rootes@csiro.au; map2028@med.cornell.edu; Adam.Meyer@csiro.au; Simon.Saubern@csiro.au; anm2047@med.cornell.edu; bmungall@live.com RI Saubern, Simon/F-7538-2012; Meyer, Adam/F-9023-2013; Rootes, Christina/H-4905-2013; OI Saubern, Simon/0000-0002-1989-4951; Rootes, Christina/0000-0002-7448-8307; Lo, Michael/0000-0002-0409-7896 FU CSIRO; NIH, National Institute of Allergy And Infectious Diseases (NIAID) [R21AI072396, U54AI057158, R56A1076335] FX BM is supported by a CSIRO Julius Award and MA is supported by a CSIRO, OCE PhD scholarship. This study was supported in part by NIH, National Institute of Allergy And Infectious Diseases (NIAID) R21AI072396 developmental awards to BAM, NIH (NIAID) Northeast Center of Excellence for Bio-defense and Emerging Infections Disease Research grant U54AI057158, Developmental and Innovation Research Grants to AM (PI of Center of Excellence grant: W.I.Lipkin) and NIH (NIAID) grant no. R56A1076335 to AM. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy And Infectious Diseases or the National Institutes of Health. We acknowledge the assistance with flow cytometry from Stanka Semova and Sergei Rudchenko in the Flow Cytometry Facility of the Hospital for Special Surgery/Weill Cornell Medical College. NR 76 TC 11 Z9 13 U1 3 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD NOV 4 PY 2009 VL 6 AR 187 DI 10.1186/1743-422X-6-187 PG 13 WC Virology SC Virology GA 526OB UT WOS:000272299300002 PM 19889218 ER PT J AU Yabroff, KR Saraiya, M Meissner, HI Haggstrom, DA Wideroff, L Yuan, G Berkowitz, Z Davis, WW Benard, VB Coughlin, SS AF Yabroff, K. Robin Saraiya, Mona Meissner, Helen I. Haggstrom, David A. Wideroff, Louise Yuan, Gigi Berkowitz, Zahava Davis, William W. Benard, Vicki B. Coughlin, Steven S. TI Specialty Differences in Primary Care Physician Reports of Papanicolaou Test Screening Practices: A National Survey, 2006 to 2007 SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID CERVICAL-CANCER PREVENTION; UNITED-STATES; OLDER WOMEN; HUMAN-PAPILLOMAVIRUS; ABNORMAL MAMMOGRAMS; COST-EFFECTIVENESS; HEALTH; BREAST; NEOPLASIA; SERVICES AB Background: Cervical cancer screening guidelines were substantially revised in 2002 and 2003. Little information is available about primary care physicians' current Papanicolaou (Pap) test screening practices, including initiation, frequency, and stopping. Objective: To assess current Pap test screening practices in the United States. Design: Cross-sectional survey. Setting: Nationally representative sample of physicians during 2006 to 2007. Participants: 1212 primary care physicians. Measurements: The survey included questions about physician and practice characteristics and recommendations for Pap screening presented as clinical vignettes describing women by age and by sexual and screening histories. A composite measure-guideline-consistent recommendations-was created by using responses to vignettes in which major guidelines were uniform. Results: Most physicians reported providing Pap tests to their eligible patients (91.0% [95% CI, 89.0% to 92.6%]). Among Pap test providers (n = 1114), screening practices, including number of tests ordered or performed, use of patient reminder systems, and cytology method used, varied by physician specialty (P < 0.001). Although most Pap test providers reported that screening guidelines were very influential in their clinical practice, few had guideline-consistent recommendations for starting and stopping Pap screening across multiple vignettes (22.3% [CI, 19.9% to 25.0%]). Guideline-consistent recommendations varied by specialty (obstetrics/gynecology, 16.4%; internal medicine, 27.5%; and family or general practice, 21.1%). Compared with obstetricians/gynecologists, internal medicine specialists and family or general practice specialists were more likely to have guideline-consistent screening recommendations (odds ratio, 1.98 [CI, 1.22 to 3.23] and 1.45 [CI, 0.99 to 2.13], respectively) in multivariate analysis. Limitation: Physician self-report may reflect idealized rather than actual practice. Conclusion: Primary care physicians' recommendations for Pap test screening are not consistent with screening guidelines, reflecting overuse of screening. Implementation of effective interventions that focus on potentially modifiable physician and practice factors is needed to improve screening practice. Primary Funding Source: National Cancer Institute, Centers for Disease Control and Prevention, and Agency for Healthcare Research and Quality. C1 [Yabroff, K. Robin] NCI, Hlth Serv, Bethesda, MD 20892 USA. NIH, Bethesda, MD 20892 USA. Informat Management Serv Inc, Silver Spring, MD USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Regenstrief Inst Hlth Care, Vet Affairs Med Ctr, Indianapolis, IN USA. Indiana Univ, Sch Med, Indianapolis, IN USA. Dept Vet Affairs, Washington, DC USA. RP Yabroff, KR (reprint author), NCI, Hlth Serv, Execut Plaza N,Room 4005,6130 Execut Blvd, Bethesda, MD 20892 USA. EM yabroffr@mail.nih.gov RI Hernandez, Jessica/G-6527-2011; OI Yabroff, K. Robin/0000-0003-0644-5572 FU National Cancer Institute [N02-PC51308]; Centers for Disease Control and Prevention [Y3-PC-6017-01]; Agency for Healthcare Research and Quality [Y3-PC-5019-01, Y3-PC-5019-02] FX By the National Cancer Institute (contract N02-PC51308), Centers for Disease Control and Prevention (interagency agreement Y3-PC-6017-01), and Agency for Healthcare Research and Quality ( interagency agreements Y3-PC-5019-01 and Y3-PC-5019-02). NR 49 TC 65 Z9 67 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 3 PY 2009 VL 151 IS 9 BP 602 EP W197 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 514IM UT WOS:000271387700002 PM 19884621 ER PT J AU Lorick, SA Fishbein, D Weintraub, E Wortley, PM Lee, GM Zhou, FJ Davis, R AF Lorick, Suchita A. Fishbein, Daniel Weintraub, Eric Wortley, Pascale M. Lee, Grace M. Zhou, Fangjun Davis, Robert TI Uptake of meningococcal conjugate vaccine among adolescents in large managed care organizations, United States, 2005: Demand, supply and seasonality SO BMC INFECTIOUS DISEASES LA English DT Article ID HEPATITIS-B VACCINATION; COVERAGE; IMPACT; TIME; LAW AB Background: In February 2005, the US Advisory Committee on Immunization Practices recommended the new meningococcal conjugate vaccine (MCV4) for routine use among 11- to 12-year-olds (at the preadolescent health-care visit), 14- to 15-year-olds (before high-school entry), and groups at increased risk. Vaccine distribution started in March; however, in July, the manufacturer reported inability to meet demand and widespread MCV4 shortages were reported. Our objectives were to determine early uptake patterns among target (11-12 and 14-15 year olds) and non-target (13-plus 16-year-olds) age groups. A post hoc analysis was conducted to compare seasonal uptake patterns of MCV4 with polysaccharide meningococcal (MPSV4) and tetanus diphtheria (Td) vaccines. Methods: We analyzed data for adolescents 11-16 years from five managed care organizations participating in the Vaccine Safety Datalink (VSD). For MCV4, we estimated monthly and cumulative coverage during 2005 and calculated risk ratios. For MPSV4 and Td, we combined 2003 and 2004 data and compared their seasonal uptake patterns with MCV4. Results: Coverage for MCV4 during 2005 among the 623,889 11-16 years olds was 10%. Coverage for 11-12 and 14-15 year olds was 12% and 11%, respectively, compared with 8% for 13-plus 16-year-olds (p < 0.001). Of the 64,272 MCV4 doses administered from March-December 2005, 73% were administered June-August. Fifty-nine percent of all MPSV4 doses and 38% of all Td doses were administered during June-August. Conclusion: A surge in vaccine uptake between June and August was observed among adolescents for MCV4, MPSV4 and Td vaccines. The increase in summer-time vaccinations and vaccination of non-targeted adolescents coupled with supply limitations likely contributed to the reported shortages of MCV4 in 2005. C1 [Lorick, Suchita A.; Fishbein, Daniel; Wortley, Pascale M.; Zhou, Fangjun] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, Atlanta, GA 30332 USA. [Lorick, Suchita A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30332 USA. [Fishbein, Daniel] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30332 USA. [Weintraub, Eric; Davis, Robert] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30332 USA. [Lee, Grace M.] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA 02215 USA. [Lee, Grace M.] Dept Populat Med, Harvard Pilgrim Hlth Care, Boston, MA 02215 USA. [Davis, Robert] Kaiser Permanente, Ctr Hlth Res, Atlanta, GA 30305 USA. RP Lorick, SA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, 1600 Clifton Rd,MS E-52, Atlanta, GA 30332 USA. EM slorick@cdc.gov; dfishbein@cdc.gov; eweintraub@cdc.gov; pwortley@cdc.gov; grace_lee@hphc.org; fzhou@cdc.gov; Robert.L.Davis@kp.org FU Centers for Disease Control and Prevention FX We would like to thank John Stevenson, Yuan Kong, and Dr. Greg Wallace for their assistance with this study. Additionally, we wish to thank the following members of the Vaccine Safety Datalink Study Project: James Baggs, Julianne Gee, (Centers for Disease Control and Prevention); Tracy Lieu, Katherine Yih, and Richard Fox, (Harvard Pilgrim); Roger Baxter, MD; Nicky Klein, and Ned Lewis, (Northern California Kaiser Permanente); Steve Jacobson, and Wansu Chen, (Southern California Kaiser Permanente); Lisa Jackson and Darren Malais, (Group Health Cooperative); Allison Naleway, John Mullooly, and Loie Drew, (Northwest Kaiser Permanente); Simon Hambridge, Jason Glanz, David McClur, and Christina Clarke, (Kaiser Permanente of Colorado); James Nordin, and Amy Butani, (Health Partners of Minneapolis); Edward Belongia, James Donahue, and Jeremy McCauley (Marshfield Clinic). NR 29 TC 5 Z9 5 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD NOV 3 PY 2009 VL 9 AR 175 DI 10.1186/1471-2334-9-175 PG 7 WC Infectious Diseases SC Infectious Diseases GA 527SN UT WOS:000272386900001 PM 19887009 ER PT J AU Oster, M Riehle-Colarusso, T Alverson, CJ Correa, A AF Oster, Matthew Riehle-Colarusso, Tiffany Alverson, Clinton J. Correa, Adolfo TI Associations of Maternal Fever and Influenza With Congenital Heart Defects SO CIRCULATION LA English DT Meeting Abstract CT 82nd Scientific Session of the American-Heart-Association CY NOV 14-18, 2009 CL Orlando, FL SP Amer Heart Assoc C1 [Oster, Matthew] Emory Univ, Atlanta, GA 30322 USA. [Riehle-Colarusso, Tiffany; Alverson, Clinton J.; Correa, Adolfo] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 3 PY 2009 VL 120 IS 18 SU 2 BP S577 EP S577 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 520GV UT WOS:000271831501323 ER PT J AU D'Onofrio, G Goldstein, AB Denisco, RA Hingson, R Heffelfinger, JD Post, LA AF D'Onofrio, Gail Goldstein, Amy B. Denisco, Richard A. Hingson, Ralph Heffelfinger, James D. Post, Lori A. TI Emergency Medicine Public Health Research Funded by Federal Agencies: Progress and Priorities SO ACADEMIC EMERGENCY MEDICINE LA English DT Article DE federal funding; public health; emergency medicine; emergency departments ID ALCOHOL INTERVENTIONS; CARE; ACCESS; RISK; DEPARTMENTS; RESISTANT; LIFE AB The emergency department (ED) visit provides an opportunity to impact the health of the public throughout the entire spectrum of care, from prevention to treatment. As the federal government has a vested interest in funding research and providing programmatic opportunities that promote the health of the public, emergency medicine (EM) is prime to develop a research agenda to advance the field. EM researchers need to be aware of federal funding opportunities, which entails an understanding of the organizational structure of the federal agencies that fund medical research, and the rules and regulations governing applications for grants. Additionally, there are numerous funding streams outside of the National Institutes of Health (NIH; the primary federal health research agency). EM researchers should seek funding from agencies according to each agency's mission and aims. Finally, while funds from the Department of Health and Human Services (HHS) are an important source of support for EM research, we need to look beyond traditional sources and appeal to other agencies with a vested interest in promoting public health in EDs. EM requires a broad skill set from a multitude of medical disciplines, and conducting research in the field will require looking for funding opportunities in a variety of traditional and not so traditional places within and without the federal government. The following is the discussion of a moderated session at the 2009 Academic Emergency Medicine consensus conference that included panel discussants from the National Institutes of Mental Health, Drug Abuse, and Alcoholism and Alcohol Abuse and the Centers for Disease Control and Prevention (CDC). Further information is also provided to discuss those agencies and centers not represented. C1 [D'Onofrio, Gail; Post, Lori A.] Yale Univ, Sch Med, Dept Emergency Med, New Haven, CT 06520 USA. [Goldstein, Amy B.] NIMH, Bethesda, MD 20892 USA. [Denisco, Richard A.] NIDA, Bethesda, MD 20892 USA. [Hingson, Ralph] NIAAA, Bethesda, MD USA. [Heffelfinger, James D.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP D'Onofrio, G (reprint author), Yale Univ, Sch Med, Dept Emergency Med, New Haven, CT 06520 USA. EM gail.donofrio@yale.edu OI D'Onofrio, Gail/0000-0002-3833-1871 FU Agency for Healthcare Research and Quality; National Institute of Mental Health; National Institute of Drug Abuse; National Institute of Alcoholism and Alcohol Abuse; Substance Abuse and Mental Health Administration Services FX The authors thank the Society for Academic Emergency Medicine for providing the forum for this presentation. In addition, we thank the many agencies, institutes, and centers for funding this conference, specifically the Agency for Healthcare Research and Quality, the National Institute of Mental Health, the National Institute of Drug Abuse, the National Institute of Alcoholism and Alcohol Abuse, and the Substance Abuse and Mental Health Administration Services. Finally, the authors thank Brian Biroscak for his help in the preparation of the manuscript. The views expressed in this article are the opinions of the authors and do not necessarily represent the views of the Department of Health and Human Services or the United States government. NR 43 TC 4 Z9 4 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2009 VL 16 IS 11 BP 1065 EP 1071 DI 10.1111/j.1553-2712.2009.00555.x PG 7 WC Emergency Medicine SC Emergency Medicine GA 515JC UT WOS:000271465000007 PM 20053224 ER PT J AU Hirshon, JM Warner, M Irvin, CB Niska, RW Andersen, DA Smith, GS McCaig, LF AF Hirshon, Jon Mark Warner, Margaret Irvin, Charlene B. Niska, Richard W. Andersen, Daniel A. Smith, Gordon S. McCaig, Linda F. TI Research Using Emergency Department-related Data Sets: Current Status and Future Directions SO ACADEMIC EMERGENCY MEDICINE LA English DT Article DE emergency departments; research; data sets; health services ID PUBLIC-HEALTH SURVEILLANCE; UNITED-STATES; INJURIES; VISITS; PREVENTION; CARE AB The 2009 Academic Emergency Medicine consensus conference focused on "Public Health in the ED: Surveillance, Screening and Intervention." One conference breakout session discussed the significant research value of health-related data sets. This article represents the proceedings from that session, primarily focusing on emergency department (ED)-related data sets and includes examples of the use of a data set based on ED visits for research purposes. It discusses types of ED-related data sets available, highlights barriers to research use of ED-related data sets, and notes limitations of these data sets. The paper highlights future directions and challenges to using these important sources of data for research, including identification of five main needs related to enhancing the use of ED-related data sets. These are 1) electronic linkage of initial and follow-up ED visits and linkage of information about ED visits to other outcomes, including costs of care, while maintaining deidentification of the data; 2) timely data access with minimal barriers; 3) complete data collection for clinically relevant and/or historical data elements, such as the external cause-of-injury code; 4) easy access to data that can be parsed into smaller jurisdictions (such as states) for policy and/or research purposes, while maintaining confidentiality; and 5) linkages between health survey data and health claims data. ED-related data sets contain much data collected directly from health care facilities, individual patient records, and multiple other sources that have significant potential impact for studying and improving the health of individuals and the population. C1 [Hirshon, Jon Mark] Univ Maryland, Sch Med, Dept Emergency Med, Baltimore, MD 21201 USA. [Hirshon, Jon Mark; Andersen, Daniel A.; Smith, Gordon S.] Univ Maryland, Sch Med, Dept Epidemiol, Baltimore, MD 21201 USA. [Hirshon, Jon Mark; Andersen, Daniel A.; Smith, Gordon S.] Univ Maryland, Sch Med, Charles McC Mathias Jr Natl Study Ctr Trauma & EM, Baltimore, MD 21201 USA. [Warner, Margaret; Niska, Richard W.; McCaig, Linda F.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Irvin, Charlene B.] St John Hosp & Med Ctr, Dept Emergency Med, Detroit, MI USA. RP Hirshon, JM (reprint author), Univ Maryland, Sch Med, Dept Emergency Med, Baltimore, MD 21201 USA. EM jhirs001@umaryland.edu OI Hirshon, Jon Mark/0000-0002-5247-529X; Smith, Gordon/0000-0002-2911-3071 FU National Heart, Lung, and Blood Institute [5K08HL073849]; National Institute of General Medical Science [T32GM075767] FX Dr. Hirshon was supported by National Heart, Lung, and Blood Institute Grant 5K08HL073849 and Dr. Andersen was supported by National Institute of General Medical Science Grant T32GM075767. NR 25 TC 16 Z9 16 U1 0 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2009 VL 16 IS 11 BP 1103 EP 1109 DI 10.1111/j.1553-2712.2009.00554.x PG 7 WC Emergency Medicine SC Emergency Medicine GA 515JC UT WOS:000271465000012 PM 20053229 ER PT J AU Woolard, R Degutis, LC Mello, M Rothman, R Cherpitel, CJ Post, LA Hirshon, JM Haukoos, JS Hungerford, DW AF Woolard, Robert Degutis, Linda C. Mello, Michael Rothman, Richard Cherpitel, Cheryl J. Post, Lori A. Hirshon, Jon Mark Haukoos, Jason S. Hungerford, Daniel W. TI Public Health in the Emergency Department: Surveillance, Screening, and Intervention-Funding and Sustainability SO ACADEMIC EMERGENCY MEDICINE LA English DT Article DE public health; research funding AB This article summarizes the work and discussions of the funding and sustainability work group at the 2009 Academic Emergency Medicine consensus conference "Public Health in the ED: Surveillance, Screening, and Intervention." The funding and sustainability session participants were asked to address the following overarching question: "What are the opportunities and what is needed to encourage academic emergency medicine (EM) to take advantage of the opportunities for funding available for public health research initiatives and build stronger academic programs focusing on public health within EM?" Prior to the session, members of the group reviewed research funding for EM in public health, as well as the priorities of federal agencies and foundations. Recommendations for actions by EM summarize the findings of workshop. C1 [Woolard, Robert] Texas Tech Univ, Dept Emergency Med, Hlth Sci Ctr, El Paso, TX USA. [Degutis, Linda C.; Post, Lori A.] Yale Univ, Dept Emergency Med, New Haven, CT USA. [Degutis, Linda C.] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Mello, Michael] Brown Univ, Rhode Isl Hosp, Dept Emergency Med, Providence, RI 02903 USA. [Mello, Michael] Brown Univ, Dept Community Hlth, Warren Alpert Med Sch, Providence, RI 02903 USA. [Rothman, Richard] Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD USA. [Cherpitel, Cheryl J.] Natl Alcohol Res Grp, Inst Publ Hlth, Berkeley, CA USA. [Hirshon, Jon Mark] Univ Maryland, Dept Emergency Med, Baltimore, MD 21201 USA. [Haukoos, Jason S.] Denver Hlth Med Ctr, Dept Emergency Med, Denver, CO USA. [Hungerford, Daniel W.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Woolard, R (reprint author), Texas Tech Univ, Dept Emergency Med, Hlth Sci Ctr, El Paso, TX USA. EM robert.woolard@ttuhsc.edu RI woolard, robert/A-7860-2011; Siry, Bonnie/D-7189-2017; OI Rothman, Richard/0000-0002-1017-9505; Hirshon, Jon Mark/0000-0002-5247-529X NR 11 TC 3 Z9 3 U1 0 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2009 VL 16 IS 11 BP 1138 EP 1142 DI 10.1111/j.1553-2712.2009.00550.x PG 5 WC Emergency Medicine SC Emergency Medicine GA 515JC UT WOS:000271465000017 PM 20053234 ER PT J AU Curtis, KM Nanda, K Kapp, N AF Curtis, Kathryn M. Nanda, Kavita Kapp, Nathalie TI Safety of hormonal and intrauterine methods of contraception for women with HIV/AIDS: a systematic review SO AIDS LA English DT Article DE AIDS; contraception; HIV; prevention of mother-to-child transmission; women ID HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED WOMEN; DEPOT MEDROXYPROGESTERONE ACETATE; SEXUALLY-TRANSMITTED INFECTIONS; HIV-1-INFECTED WOMEN; DISEASE PROGRESSION; GENITAL-TRACT; RISK-FACTORS; ANTIRETROVIRAL THERAPY; KENYAN WOMEN AB Objective: To determine from the literature whether HIV-infected women who use hormonal or intrauterine contraception are at increased risk of HIV disease progression, other adverse health outcomes, or HIV transmission to uninfected sexual partners. Design: A systematic review. Methods: We searched PubMed for articles published in peer-reviewed journals through August 2009 for evidence relevant to all hormonal and intrauterine contraceptive methods and HIV/AIDS. Results: Eight observational studies reported no increased risk of HIV disease progression with hormonal or intrauterine contraceptive use, whereas one randomized controlled trial found increased risks of declining CD4 cell count and death for hormonal contraceptive users compared with intrauterine device users. Women with HIV who used hormonal contraception had increased risks of acquiring sexually transmitted infections compared with women not using hormonal contraception, similar to the risks reported among uninfected women. One study found no association between hormonal or intrauterine contraceptive use and increased risk of HIV transmission to uninfected partners, whereas findings from nine studies examining contraceptive use and viral shedding from the genital tract were inconsistent. Conclusion: Evidence regarding the safety of hormonal and intrauterine contraceptive use among women with HIV remains limited, but generally reassuring regarding adverse health effects, disease transmission to uninfected partners, and disease progression; however, one randomized trial raised concerns about enhanced disease progression among women using hormonal contraception. Preventing unintended pregnancy among women with HIV remains a high priority in public health, both for the health of the woman as well as for the prevention of mother-to-child transmission of HIV. (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Nanda, Kavita] Family Hlth Int, Res Triangle Pk, NC 27709 USA. [Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland. RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, MS K-34,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM Kmc6@cdc.gov FU World Health Organization; US Centers for Disease Control and Prevention (CDC); US Agency for International Development (USAID); US National Institute of Child Health and Human Development (NICHD) FX This review was supported by resources from the World Health Organization, the US Centers for Disease Control and Prevention (CDC), US Agency for International Development (USAID) and the US National Institute of Child Health and Human Development (NICHD). NR 44 TC 36 Z9 36 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD NOV PY 2009 VL 23 BP S55 EP S67 PG 13 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 524IB UT WOS:000272135900007 PM 20081389 ER PT J AU Whiteman, MK Kissin, DM Samarina, A Curtis, KM Akatova, N Marchbanks, PA Jamieson, DJ Martirosyan, M Revzina, N Hillis, SD AF Whiteman, Maura K. Kissin, Dmitry M. Samarina, Anna Curtis, Kathryn M. Akatova, Natalia Marchbanks, Polly A. Jamieson, Denise J. Martirosyan, Margarita Revzina, Natalya Hillis, Susan D. TI Determinants of contraceptive choice among women with HIV SO AIDS LA English DT Article DE attitudes; choice behavior; contraceptive devices; women; health knowledge; HIV; practice ID INFECTED WOMEN; ST-PETERSBURG; UNITED-STATES; TRANSMISSION; PREGNANCY; CONDOMS; RUSSIA; COHORT; RISK; US AB Objective: To examine factors associated with contraceptive choice among HIV-infected women. Design: Data for this cross-sectional analysis were derived from baseline visits of 435 participants in an ongoing prospective study of contraception among HIV-infected women in Russia. Participants enrolled in one of four groups: combined oral contraceptives (COCs) along with condoms, depot medroxyprogesterone acetate (DMPA) along with condoms, copper intrauterine device (IUD) along with condoms, or condoms alone. Methods: After contraceptive counseling and assessment of medical eligibility to use study methods, participants selected a method. Standardized interviews were used to collect demographic, reproductive and behavioral information. Results: Most women were eligible to use COCs (899%) and DMPA (94%); 87% of nonpostpartum women were eligible to use the IUD. The method chosen by most women was condoms alone (47%), followed by COCs along with condoms (29%), DMPA along with condoms (20%) and IUD along with condoms (4%). In multivariable analyses, independent predictors of choosing a method highly effective during typical use (COCs, DMPA, or IUD) along with condoms included having at least two births (prevalence ratio=1.4), postpartum enrolment (prevalence ratio=1.3), desiring (prevalence ratio=1.4), or uncertainty about desiring (prevalence ratio=1.3) a future pregnancy, prior oral contraceptive use (prevalence ratio = 1.3), recent injection drug use (prevalence ratio = 1.3) and never (prevalence ratio = 2.3) or sometimes (prevalence ratio = 1.9) using condoms in the last year. Conclusion: Among HIV-infected women, several characteristics that may place women at greater risk for unintended pregnancy and its adverse consequences were associated with choice of highly effective contraceptive methods. These findings may aid in the development of interventions to increase use of effective contraception among HIV-infected women. (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Whiteman, Maura K.; Kissin, Dmitry M.; Curtis, Kathryn M.; Marchbanks, Polly A.; Jamieson, Denise J.; Revzina, Natalya; Hillis, Susan D.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Akatova, Natalia; Martirosyan, Margarita] St Petersburg City AIDS Ctr, St Petersburg, Russia. [Samarina, Anna] Ott Res Inst Obstet & Gynecol, St Petersburg, Russia. RP Whiteman, MK (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-34, Atlanta, GA 30341 USA. EM acq5@cdc.gov FU United States Agency for International Development, Russia; CDC FX This study was funded by United States Agency for International Development, Russia through an Interagency Agreement with the CDC. NR 27 TC 10 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD NOV PY 2009 VL 23 BP S47 EP S54 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 524IB UT WOS:000272135900006 PM 20081388 ER PT J AU Switzer, W Sintasath, D Pike, B Djoko, C Ngole, EM Diffo, JLD Peeters, M Lebreton, M Wolfe, N Tamoufe, U Heneine, W AF Switzer, W. Sintasath, D. Pike, B. Djoko, C. Ngole, E. M. Diffo, J. L. D. Peeters, M. Lebreton, M. Wolfe, N. Tamoufe, U. Heneine, W. TI Characterization of the Complete Genome of a Highly Divergent Simian T-Lymphotropic Virus (STLV) Type 3 Obtained Entirely from Dried Blood Spots of a Cercopithecus mona Monkey SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT 14th International Conference on Human Retrovirology HTLV and Related Retroviruses CY JUL 01-04, 2009 CL Salvador, BRAZIL C1 [Switzer, W.; Sintasath, D.; Pike, B.; Djoko, C.; Ngole, E. M.; Diffo, J. L. D.; Peeters, M.; Lebreton, M.; Wolfe, N.; Tamoufe, U.; Heneine, W.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 2009 VL 25 IS 11 BP 1252 EP 1252 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 524ZF UT WOS:000272182200148 ER PT J AU Schleicher, RL Carroll, MD Ford, ES Lacher, DA AF Schleicher, Rosemary L. Carroll, Margaret D. Ford, Earl S. Lacher, David A. TI Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES) SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; ASCORBIC-ACID; CARDIOVASCULAR-DISEASE; BETA-CAROTENE; US POPULATION; VEGETABLE CONSUMPTION; PHYSICIANS HEALTH; EYE DISEASE; PREVENTION; CANCER AB Background: Vitamin C (ascorbic acid) may be the most important water-soluble antioxidant in human plasma. In the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994), approximate to 13% of the US population was vitamin C deficient (serum concentrations <11.4 mu mol/L). Objective: The aim was to determine the most current distribution of serum vitamin C concentrations in the United States and the prevalence of deficiency in selected subgroups. Design: Serum concentrations of total vitamin C were measured in 7277 noninstitutionalized civilians aged >6 y during the cross-sectional, nationally representative NHANES 2003-2004. The prevalence of deficiency was compared with results from NHANES III. Results: The overall age-adjusted mean from the square-root transformed (SM) concentration was 51.4 mu mol/L (95% CI: 48.4, 54.6). The highest concentrations were found in children and older persons. Within each race-ethnic group, women had higher concentrations than did men (P < 0.05). Mean concentrations of adult smokers were one-third lower than those of nonsmokers (SM: 35.2 compared with 50.7 mu mol/L and 38.6 compared with 58.0 mu mol/L in men and women, respectively). The overall prevalence (+/- SE) of age-adjusted vitamin C deficiency was 7.1 +/- 0.9%. Mean vitamin C concentrations increased (P < 0.05) and the prevalence of vitamin C deficiency decreased (P < 0.01) with increasing socioeconomic status. Recent vitamin C supplement use or adequate dietary intake decreased the risk of vitamin C deficiency (P < 0.05). Conclusions: In NHANES 2003-2004, vitamin C status improved, and the prevalence of vitamin C deficiency was significantly lower than that during NHANES III, but smokers and low-income persons were among those at increased risk of deficiency. Am J Clin Nutr 2009; 90: 1252-63. C1 [Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Carroll, Margaret D.; Lacher, David A.] Ctr Dis Control & Prevent, Div Hlth Examinat Stat, Natl Ctr Hlth Stat, Atlanta, GA 30341 USA. [Ford, Earl S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Schleicher, RL (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F55, Atlanta, GA 30341 USA. EM rschleicher@cdc.gov NR 64 TC 99 Z9 99 U1 1 U2 17 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV 1 PY 2009 VL 90 IS 5 BP 1252 EP 1263 DI 10.3945/ajcn.2008.27016 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 508TO UT WOS:000270959500020 PM 19675106 ER PT J AU Flegal, KM Wei, R Ogden, CL Freedman, DS Johnson, CL Curtin, LR AF Flegal, Katherine M. Wei, Rong Ogden, Cynthia L. Freedman, David S. Johnson, Clifford L. Curtin, Lester R. TI Characterizing extreme values of body mass index-for-age by using the 2000 Centers for Disease Control and Prevention growth charts SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID ADOLESCENT OVERWEIGHT; US CHILDREN; DETECTION LIMITS; CENTILE CURVES; LMS METHOD; OBESITY; RECOMMENDATIONS; PREVALENCE; STANDARDS; WEIGHT AB Background: The 2000 Centers for Disease Control and Prevention (CDC) growth charts included lambda-mu-sigma (LMS) parameters intended to calculate smoothed percentiles from only the 3rd to the 97th percentile. Objective: The objective was to evaluate different approaches to describing more extreme values of body mass index (BMI)-for-age by using simple functions of the CDC growth charts. Design: Empirical data for the 99th and the 1st percentiles of BMI-for-age were calculated from the data set used to construct the growth charts and were compared with estimates extrapolated from the CDC-supplied LMS parameters and to various functions of other smoothed percentiles. A set of reestimated LMS parameters that incorporated a smoothed 99th percentile were also evaluated. Results: Extreme percentiles extrapolated from the CDC-supplied LMS parameters did not match well to the empirical data for the 99th percentile. A better fit to the empirical data was obtained by using 120% of the smoothed 95th percentile. The empirical first percentile was reasonably well approximated by extrapolations from the LMS values. The reestimated LMS parameters had several drawbacks and no clear advantages. Conclusions: Several approximations can be used to describe extreme high values of BMI-for-age with the use of the CDC growth charts. Extrapolation from the CDC-supplied LMS parameters does not provide a good fit to the empirical 99th percentile values. Simple approximations to high values as percentages of the existing smoothed percentiles have some practical advantages over imputation of very high percentiles. The expression of high BMI values as a percentage of the 95th percentile can provide a flexible approach to describing and tracking heavier children. Am J Clin Nutr 2009; 90: 1314-20. C1 [Flegal, Katherine M.; Wei, Rong; Ogden, Cynthia L.; Johnson, Clifford L.; Curtin, Lester R.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Freedman, David S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Flegal, KM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 4201, Hyattsville, MD 20782 USA. EM kmf2@cdc.gov RI Flegal, Katherine/A-4608-2013; OI Flegal, Katherine/0000-0002-0838-469X NR 26 TC 121 Z9 125 U1 1 U2 9 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV 1 PY 2009 VL 90 IS 5 BP 1314 EP 1320 DI 10.3945/ajcn.2009.28335 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 508TO UT WOS:000270959500027 PM 19776142 ER PT J AU Yong, LC Petersen, MR Sigurdson, AJ Sampson, LA Ward, EM AF Yong, Lee C. Petersen, Martin R. Sigurdson, Alice J. Sampson, Laura A. Ward, Elizabeth M. TI High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID IONIZING-RADIATION; FREE-RADICALS; VITAMINS C; CANCER; VEGETABLES; DAMAGE; REPRODUCIBILITY; QUESTIONNAIRE; CAROTENOIDS; VALIDITY AB Background: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. Objective: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. Design: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. Results: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios ( 95% CI) for >= median compared with, = median compared with, median combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55). Conclusion: High combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons. Am J Clin Nutr 2009;90:1402-10. C1 [Yong, Lee C.] NIOSH, Ctr Dis Control & Prevent, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Sigurdson, Alice J.] NCI, NIH, Bethesda, MD 20892 USA. [Sampson, Laura A.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Ward, Elizabeth M.] Amer Canc Soc, Atlanta, GA 30329 USA. RP Yong, LC (reprint author), NIOSH, Ctr Dis Control & Prevent, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,R-15, Cincinnati, OH 45226 USA. EM lay7@cdc.gov FU National Institute for Occupational Safety and Health and the National Cancer Institute [Y1CP802904]; Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute FX Supported in part by an interagency agreement between the National Institute for Occupational Safety and Health and the National Cancer Institute ( contract Y1CP802904) and by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute. NR 40 TC 11 Z9 11 U1 0 U2 2 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV 1 PY 2009 VL 90 IS 5 BP 1402 EP 1410 DI 10.3945/ajcn.2009.28207 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 508TO UT WOS:000270959500038 PM 19793852 ER PT J AU Cassidy, W Marioneaux, DM Windham, AF Manning, S Fishbein, D Horswell, RL AF Cassidy, William Marioneaux, Dale M. Windham, Aubrey F. Manning, Susan Fishbein, Daniel Horswell, Ronald L. TI Factors influencing acceptance of influenza vaccination given in an ED SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID PNEUMOCOCCAL VACCINATION; IMMUNIZATION; EMERGENCY; DISPARITIES; ADULTS; AMERICANS AB Factors correlating with successful administration of flu vaccine in an emergency department (ED) were examined. Patients 18 years and older were screened for indications for flu immunization. Vaccine was offered to those with indications. Of 3425 patients screened, 1311 had indications, 705 of 1311 agreed to immunization, and 513 of 705 were immunized. Factors related to immunization agreement were comorbidity, interviewer, and being 50 to 64 years old with prior immunization. Immunization factors were month, comorbidity, and not being pregnant. Factors associated with Suboptimal acceptance and receipt should be addressed in future efforts. (C) 2009 Published by Elsevier Inc. C1 [Horswell, Ronald L.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cassidy, William; Marioneaux, Dale M.; Windham, Aubrey F.] Louisiana State Univ, Hlth Sci Ctr, Earl K Long Med Ctr, Baton Rouge, LA 70805 USA. [Manning, Susan; Fishbein, Daniel] Ctr Dis Control, Atlanta, GA 30329 USA. RP Horswell, RL (reprint author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. EM wcassi@lsuhsc.edu; susan.manning@cdc.hhs.gov; daniel.fishbein@cdc.hhs.gov; ronald.horswell@lsuhsc.edu NR 17 TC 5 Z9 5 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD NOV PY 2009 VL 27 IS 9 BP 1027 EP 1033 DI 10.1016/j.ajem.2008.05.014 PG 7 WC Emergency Medicine SC Emergency Medicine GA 527XB UT WOS:000272403400001 PM 19931746 ER PT J AU Reutman, SR Rohs, AM Clark, JC Johnson, BC Sammons, DL Toennis, CA Robertson, SA MacKenzie, BA Lockey, JE AF Reutman, Susan R. Rohs, Amy M. Clark, John C. Johnson, Belinda C. Sammons, Deborah L. Toennis, Christine A. Robertson, Shirley A. MacKenzie, Barbara A. Lockey, James E. TI A Pilot Respiratory Health Assessment of Nail Technicians: Symptoms, Lung Function, and Airway Inflammation SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE nail technicians; artificial nails; lung function; exhaled nitric oxide; smoking ID STANDARDIZATION; ASTHMA AB Background Recent surveys suggest nail technicians, particularly artificial nail applicators, have increased respiratory symptoms and asthma risk. Methods We examined lung function (n = 62) and a marker of airway inflammation, i.e., exhaled nitric oxide (ENO) (n = 43), in a subset of nail technician and control participants in a pilot health assessment. Results Bivariate analysis of technicians demonstrated that job latency was inversely correlated with FEV1 percent predicted (FEV1PP) (r = -0.34, P = 0.03) and FVCPP (r = -0.32, P = 0.05). Acrylic gel contact hours were inversely correlated with FEV1PP (r = -0.38, P = 0.02) and FVCPP (r = -0.47, P = 0.003). Current smoking was inversely and significantly (P <= 0.05) associated with ENO in bivariate analysis. Log 10 ENO levels were directly correlated with job latency (P = 0.012) and gel nail application (P = 0.026) in multivariable analyses. Conclusions These positive pilot respiratory test results warrant additional future investigation. Am. J. Ind. Med. 52:868-875, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Reutman, Susan R.; Clark, John C.; Johnson, Belinda C.; Sammons, Deborah L.; Toennis, Christine A.; Robertson, Shirley A.; MacKenzie, Barbara A.] NIOSH, BHAB, DART, Cincinnati, OH 45226 USA. [Rohs, Amy M.; Lockey, James E.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45221 USA. [Rohs, Amy M.; Lockey, James E.] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH 45221 USA. RP Reutman, SR (reprint author), NIOSH, BHAB, DART, 4676 Columbia Pkwy,Mail Stop C-23, Cincinnati, OH 45226 USA. EM swr0@cdc.gov RI Reutman, Susan/C-2459-2012 FU NIOSH National Occupational Research Agenda (NORA) [8927Z1JN] FX Contract grant sponsor: NIOSH National Occupational Research Agenda (NORA); Contract grant number: 8927Z1JN. NR 11 TC 9 Z9 10 U1 0 U2 5 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD NOV PY 2009 VL 52 IS 11 BP 868 EP 875 DI 10.1002/ajim.20751 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 513DO UT WOS:000271302800006 PM 19753596 ER PT J AU Finkelstein, EA Tangka, FK Trogdon, JG Sabatino, SA Richardson, LC AF Finkelstein, Eric A. Tangka, Florence K. Trogdon, Justin G. Sabatino, Susan A. Richardson, Lisa C. TI The Personal Financial Burden of Cancer for the Working-Aged Population SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID COLORECTAL-CANCER; PROSTATE-CANCER; BREAST-CANCER; UNITED-STATES; HEALTH-CARE; COSTS; EMPLOYMENT; INSURANCE AB Objective: To present nationally representative estimates of the effect of cancer care on out-of-pocket medical expenditures and lost productivity for the working-aged population. Study Design: Secondary data analysis. Methods: Pooled data from the Medical Expenditure Panel Survey were used for the analysis. We constructed the following 4 respondent groups for comparison during the analysis period: (1) respondents with no cancer, and (among those who reported having cancer) (2) respondents with active cancer care, (3) respondents with follow-up cancer care, and (4) respondents with no cancer care. Using regression analysis, we estimated the effect of being in each of the cancer care groups on out-of-pocket medical expenditures, the probability of being employed, and the annual number of workdays missed because of illness or injury. Results: Being actively treated for cancer increases the mean annual out-of-pocket medical expenditures by $1170 compared with not having cancer. Less intensive cancer care is associated with lower medical expenditures (but still higher than for those without cancer). Respondents undergoing active cancer care were less likely to be employed full-time. Among respondents who were employed, those undergoing active cancer care missed 22.3 more workdays per year than those without cancer. Conclusion: Changes to the health system need to consider not only how to reduce inappropriate medical utilization but also how to ensure that those diagnosed as having cancer and other serious medical conditions will not be doubly burdened with poor health and high medical expenditures. (Am J Manag Care. 2009;15(11):801-806) C1 [Finkelstein, Eric A.] Duke Natl Univ Singapore, Grad Sch Med, Div Hlth Serv Res, Singapore, Singapore. [Trogdon, Justin G.] RTI Int, Publ Hlth Econ Program, Res Triangle Pk, NC USA. [Tangka, Florence K.; Sabatino, Susan A.; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Finkelstein, EA (reprint author), Duke Natl Univ Singapore, Grad Sch Med, Div Hlth Serv Res, Singapore, Singapore. EM eric.finkelstein@duke-nus.edu.sg FU Centers for Disease Control and Prevention [200-2002-00575] FX This work was supported by the Centers for Disease Control and Prevention under contract 200-2002-00575 to RTI International. The findings and conclusions are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 23 TC 29 Z9 29 U1 1 U2 4 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD NOV PY 2009 VL 15 IS 11 BP 801 EP 806 PG 6 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 521QI UT WOS:000271936800004 PM 19895184 ER PT J AU Jenkins, MM Reed-Gross, E Rasmussen, SA Barfield, WD Prue, CE Gallagher, ML Honein, MA AF Jenkins, Mary M. Reed-Gross, Erika Rasmussen, Sonja A. Barfield, Wanda D. Prue, Christine E. Gallagher, Margaret L. Honein, Margaret A. TI Maternal Attitudes Toward DNA Collection for Gene-Environment Studies: A Qualitative Research Study SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE focus groups; qualitative research; epidemiologic studies; genetic research ID BIRTH-DEFECTS PREVENTION; RACIAL-DIFFERENCES; INFORMED-CONSENT; GENOMIC DNA; RECRUITMENT; PARTICIPATION; DISTRUST; COHORT; WILLINGNESS; POPULATIONS AB To assess attitudes toward DNA collection in an epidemiological study, focus groups were assembled in September 2007 with mothers who had participated in a case-control study of birth defects. Each recruited mother previously had completed an interview and had received a mailed kit containing cytobrushes to collect buccal cells for DNA from herself, her infant, and her infant's father during the period July 2004 through July 2007. A total of 38 mothers attended six focus groups comprising: (1) non-Hispanic Black mothers of case infants who participated or (2) did not participate in DNA collection, (3) mothers of any race or ethnicity who had case infants of low birth weight who participated or (4) did not participate in DNA collection, and (5) non-Hispanic Black mothers of control infants who participated or (6) did not participate in DNA collection. Moderator-led discussions probed maternal attitudes toward providing specimens, factors that influenced decision making, and collection method preferences. Biologics participants reported that they provided DNA for altruistic reasons. Biologics nonparticipants voiced concerns about government involvement and how their DNA will be used. Information provided (or not provided) on DNA use, storage, and disposal influenced decision making. Biologics participants and nonparticipants reported that paternal skepticism was a barrier to participation. All mothers were asked to rank DNA collection methods in terms of preference (cytobrushes, saliva, mouthwash, newborn blood spots, and blood collection). Preferred methods were convenient and noninvasive. Better understanding attitudes toward DNA collection and preferred collection methods might allow more inclusive participation and benefit future studies. Published 2009 Wiley-Liss, Inc.(dagger) C1 [Jenkins, Mary M.; Rasmussen, Sonja A.; Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Reed-Gross, Erika] WESTAT Corp, Rockville, MD 20850 USA. [Barfield, Wanda D.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Prue, Christine E.] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA. [Gallagher, Margaret L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. RP Jenkins, MM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,M-S E-86, Atlanta, GA 30333 USA. EM mmjenkins@cdc.gov NR 28 TC 11 Z9 11 U1 1 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD NOV PY 2009 VL 149A IS 11 BP 2378 EP 2386 DI 10.1002/ajmg.a.33043 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA 517BL UT WOS:000271587600005 PM 19839045 ER PT J AU Ho, CS Bhatnagar, J Cohen, AL Hacker, JK Zane, SB Reagan, S Fischer, M Shieh, WJ Guarner, J Ahmad, S Zaki, SR McDonald, LC AF Ho, Christine S. Bhatnagar, Julu Cohen, Adam L. Hacker, Jill K. Zane, Suzanne B. Reagan, Sarah Fischer, Marc Shieh, Wun-Ju Guarner, Jeannette Ahmad, Shabbir Zaki, Sherif R. McDonald, L. Clifford TI Undiagnosed cases of fatal Clostridium-associated toxic shock in Californian women of childbearing age SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE Clostridium perfringens; Clostridium sordellii; medical abortion; mifepristone; toxic shock ID SORDELLII LETHAL TOXIN; MIFEPRISTONE ABORTION; POSTPARTUM; PERFRINGENS; DIFFICILE; INFECTION; EPIDEMIC; CONTEXT; DISEASE; STRAIN AB OBJECTIVE: In 2005, 4 Clostridium sordellii-associated toxic shock fatalities were reported in young Californian women after medical abortions. The true incidence of this rare disease is unknown, and a population-based study has never been performed. Additional clostridia-associated deaths were sought to describe associated clinical characteristics. STUDY DESIGN: Population-based death certificate review and a clinical case definition for clostridial-associated toxic shock identified women with likelihood of dying from a Clostridium infection. Formalin-fixed autopsy tissues underwent immunohistochemical and polymerase chain reaction assays. RESULTS: Thirty-eight women were suspected of having C sordellii-associated death. Five tested positive for Clostridium species: 3 for Clostridium perfringens, 1 for C sordellii, and 1 for both. Deaths occurred after the medical procedures for cervical dysplasia (n = 2), surgical abortion (n = 1), stillborn delivery (n = 1), and term live birth (n = 1). None had a medical abortion. CONCLUSION: C sordellii and C perfringens are associated with undiagnosed catastrophic infectious gynecologic illnesses among women of childbearing age. C1 [Ho, Christine S.; Hacker, Jill K.] Calif Emerging Infect Program, Surveillance Unexplained Deaths SUDS Project, Oakland, CA USA. [Bhatnagar, Julu; Shieh, Wun-Ju; Guarner, Jeannette; Zaki, Sherif R.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Infect Dis Pathol Branch, Atlanta, GA USA. [Cohen, Adam L.; McDonald, L. Clifford] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Prevent & Response Branch, Atlanta, GA USA. [Zane, Suzanne B.] Ctr Dis Control & Prevent, Div Reprod Hlth, Maternal & Infant Hlth Branch, Atlanta, GA USA. [Reagan, Sarah; Fischer, Marc] Ctr Dis Control & Prevent, Div Bacterial & Mycot Dis, Unexplained Deaths Project, Atlanta, GA USA. [Ahmad, Shabbir] Calif Maternal Child & Adolescent Hlth Program, Sacramento, CA USA. RP Ho, CS (reprint author), SFDPH TB Control 1001 Potrero Ave,Ward 94, San Francisco, CA 94110 USA. EM gtb9@cdc.gov RI Guarner, Jeannette/B-8273-2013 FU Centers for Disease Control and Prevention Cooperative Agreement [1-U01/CI000309-02]; California Emerging Infections Program, Oakland, CA FX This study was supported by the Centers for Disease Control and Prevention Cooperative Agreement no. 1-U01/CI000309-02, California Emerging Infections Program, Oakland, CA. NR 29 TC 6 Z9 6 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD NOV PY 2009 VL 201 IS 5 AR 459.e1 DI 10.1016/j.ajog.2009.05.023 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 514FO UT WOS:000271379900014 PM 19628200 ER PT J AU Cleveland, JL Kohn, W AF Cleveland, Jennifer L. Kohn, William TI CDC weighs in on TADs SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Letter C1 [Cleveland, Jennifer L.; Kohn, William] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Oral Hlth, Atlanta, GA 30333 USA. RP Cleveland, JL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Oral Hlth, Atlanta, GA 30333 USA. NR 2 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD NOV PY 2009 VL 136 IS 5 BP 622 EP 623 DI 10.1016/j.ajodo.2009.09.008 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 514WF UT WOS:000271426100005 PM 19892264 ER PT J AU Brown, DW Anda, RF Tiemeier, H Felitti, VJ Edwards, VJ Croft, JB Giles, WH AF Brown, David W. Anda, Robert F. Tiemeier, Henning Felitti, Vincent J. Edwards, Valerie J. Croft, Janet B. Giles, Wayne H. TI Adverse Childhood Experiences and the Risk of Premature Mortality SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID NATIONAL DEATH INDEX; HOUSEHOLD DYSFUNCTION; SEXUAL-ABUSE; PREVALENCE; VICTIMIZATION; CHILDREN; NEGLECT AB Background: Strong, graded relationships between exposure to childhood traumatic stressors and numerous negative health behaviors and outcomes, healthcare utilization, and overall health status inspired the question of whether these adverse childhood experiences (ACEs) are associated with premature death during adulthood. Purpose: This study aims to determine whether ACEs are associated with an increased risk of premature death during adulthood. Methods: Baseline survey data on health behaviors, health status, and exposure to ACEs were collected from 1.7,337 adults aged >18 years during 1995-1997. The ACEs included abuse (emotional, physical, sexual); witnessing domestic violence; parental separation or divorce; and growing up in a household where members were men tally ill, substance abusers, or sent to prison. The ACE score (air integer count of the eight categories of ACEs) was used as a measure of cumulative exposure to traumatic stress during childhood. Deaths were identified during follow-up assessments (between baseline appointment date and December 31, 2006) using mortality records obtained from a search of the National Death Index. Expected years of life lost (YLL) and yews of potential life lost (YPLL) were computed using standard methods. The relative fisk of death from all causes at age <= 65),cars and at age <= 75 years was estimated across the number of categories of ACEs using multivaribale-adjusted Cox proportional hazards regression. Analysis was conducted during January-February 2009. Results: Overall, 1539 people died during follow-up; the crude death rate was 91.0 per 1000; the age-adjusted rate was 54.7 per 1000. People with six or more ACEs died nearly 20 years earlier on average than those without ACEs (60.6 years, 95% CI = 56.2, 65.1, vs 79.1 years, 95% CI = 78.4, 79.9). Average YLL per death was nearly three times greater among people with six or more ACEs (25.2 years) than those without ACEs (9.2 years). Roughly one third (n = 526) of those who died during follow-up were aged <= 75 years at the time of death, accounting for 4792 YPLL. After multivariable adjustment, adults with six or more ACEs were 1.7 (95% CI = 1.06, 2.83) times more likely to die when aged <= 75 years and 2.4 (95% CI = 1.30, 4.39) times more likely to die when aged <= 65 years. Conclusions: ACEs are associated with an increased risk of premature death, although a graded increase in the risk of premature death was not observed across the number of categories of ACEs. The increase in risk was only partly explained by documented ACE-related health and social problems, suggesting other possible mechanisms by which ACEs may contribute to premature death. (Am J Prev Med 2009;37(5):389-396) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Brown, David W.; Anda, Robert F.; Edwards, Valerie J.; Croft, Janet B.; Giles, Wayne H.] CDC, Atlanta, GA 30333 USA. [Brown, David W.] Erasmus Univ, Med Ctr, Netherlands Inst Hlth Sci, Rotterdam, Netherlands. [Tiemeier, Henning] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands. [Tiemeier, Henning] Erasmus Univ, Med Ctr, Dept Child Psychiat, Rotterdam, Netherlands. [Felitti, Vincent J.] Kaiser Permanente, So Calif Permanente Med Grp, San Diego, CA USA. RP Brown, DW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,MS K67, Atlanta, GA 30341 USA. EM dbrown6@cdc.gov OI Tiemeier, Henning/0000-0002-4395-1397 NR 27 TC 180 Z9 183 U1 1 U2 37 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD NOV PY 2009 VL 37 IS 5 BP 389 EP 396 DI 10.1016/j.amepre.2009.06.021 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 516HM UT WOS:000271532800002 PM 19840693 ER PT J AU Graham, GN Spengler, RF AF Graham, Garth N. Spengler, Robert F. TI Collaborating to End Health Disparities in Our Lifetime SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material C1 [Graham, Garth N.] Off Minor Hlth, Dept Hlth & Human Serv, Off Secretary, Rockville, MD 20852 USA. [Spengler, Robert F.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Graham, GN (reprint author), Off Minor Hlth, Dept Hlth & Human Serv, Off Secretary, 1001 Wootton Pkwy, Rockville, MD 20852 USA. EM garth.graham@hhs.gov NR 13 TC 2 Z9 2 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 1930 EP 1932 DI 10.2105/AJPH.2009.167908 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900007 PM 19762653 ER PT J AU Purcell, DW McCree, DH AF Purcell, David W. McCree, Donna Hubbard TI Recommendations From a Research Consultation to Address Intervention Strategies for HIV/AIDS Prevention Focused on African Americans SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID UNITED-STATES; BEHAVIORAL INTERVENTIONS; EFFICACY AB Despite substantial federal resources spent on HIV prevention, research, treatment, and care, as well as the availability and dissemination of evidence-based behavioral interventions, the disparate impact of HIV on African Americans continues. In October 2007, 3 federal agencies convened 20 HIV/AIDS prevention researchers and care providers for a research consultation to focus on new intervention strategies and current effective intervention strategies that should be more widely disseminated to address the HIV/AIDS epidemic among African Americans. The consultants focused on 2 areas: (1) potential directions for HIV prevention interventions, defined to include behavioral, community, testing, service delivery, structural, biomedical, and other interventions; and (2) improved research methods and agency procedures to better support prevention research focused on African American communities. (Am J Public Health. 2009;99:1937-1940. doi:10.2105/AJPH.2008.152546) C1 [Purcell, David W.; McCree, Donna Hubbard] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Purcell, DW (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd,MS E-37, Atlanta, GA 30333 USA. EM dpurcell@cdc.gov OI Purcell, David/0000-0001-8125-5168 NR 9 TC 15 Z9 15 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 1937 EP 1940 DI 10.2105/AJPH.2008.152546 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900009 PM 19762665 ER PT J AU Rashid, JR Spengler, RF Wagner, RM Melanson, C Skillen, EL Mays, RA Heurtin-Roberts, S Long, JA AF Rashid, Jamila R. Spengler, Robert F. Wagner, Robin M. Melanson, Cindi Skillen, Elizabeth L. Mays, Robert A., Jr. Heurtin-Roberts, Suzanne Long, Judith A. TI Eliminating Health Disparities Through Transdisciplinary Research, Cross-Agency Collaboration, and Public Participation SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID UNITED-STATES; TRENDS; SCIENCE; DISEASE AB Despite efforts to the contrary, disparities in health and health care persist in the United States. To solve this problem, federal agencies representing different disciplines and perspectives are collaborating on a variety of transdisciplinary research initiatives. The most recent of these initiatives was launched in 2006 when the Centers for Disease Control and Prevention's Office of Public Health Research and the Department of Health and Human Services' Office of Minority Health brought together federal partners representing a variety of disciplines to form the Federal Collaboration on Health Disparities Research (FCHDR). FCHDR collaborates with a wide variety of federal and nonfederal partners to support and disseminate research that aims to reduce or eliminate disparities in health and health care. Given the complexity involved in eliminating health disparities, there is a need for more transdisciplinary, collaborative research, and facilitating that research is FCHDR's mission. (Am J Public Health. 2009;99:1955-1961. doi:10.2105/AJPH.2009.167932) C1 [Rashid, Jamila R.; Spengler, Robert F.; Wagner, Robin M.; Melanson, Cindi; Skillen, Elizabeth L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heurtin-Roberts, Suzanne] Off Minor Hlth, Dept Hlth & Human Serv, Rockville, MD USA. [Mays, Robert A., Jr.] NIH, Bethesda, MD 20892 USA. [Long, Judith A.] Philadelphia VA Ctr Hlth Equ Res & Promot, Dept Vet Affairs, Philadelphia, PA USA. RP Rashid, JR (reprint author), HHS, Off Minor Hlth, 1101 Wootton Pkwy,Suite 600, Rockville, MD 20852 USA. EM jamila.rashid@hhs.gov RI Heurtin-Roberts, Suzanne/D-7274-2013 NR 31 TC 16 Z9 16 U1 0 U2 9 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 1955 EP 1961 DI 10.2105/AJPH.2009.167932 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900012 PM 19762652 ER PT J AU Safran, MA Mays, RA Huang, LN McCuan, R Pham, PK Fisher, SK McDuffie, KY Trachtenberg, A AF Safran, Marc A. Mays, Robert A., Jr. Huang, Larke Nahme McCuan, Ron Pham, Phuong Kim Fisher, Sylvia Kay McDuffie, Kathleen Y. Trachtenberg, Alan TI Mental Health Disparities SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID INTERNATIONAL DIAGNOSTIC INTERVIEW; DSM-IV; LIMITATIONS; PARADIGM; VALIDITY; ILLNESS AB Mental health disparities have received increased attention in the literature in recent years. After considering 165 different health disparity conditions, the Federal Collaborative for Health Disparities Research chose mental health disparity as one of four topics warranting its immediate national research attention. In this essay, we describe the challenges and opportunities encountered in developing a research agenda to address mental health disparities in the United States. Varying definitions of mental health disparity, the heterogeneity of populations facing such disparity, and the power, complexity, and intertwined nature of contributing factors are among the many challenges. We convey an evolving interagency approach to mental health disparities research and guidance for further work in the field. (Am J Public Health. 2009;99:1962-1966. doi:10.2105/AJPH.2009.167346) C1 [Safran, Marc A.; McDuffie, Kathleen Y.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Mays, Robert A., Jr.; Pham, Phuong Kim] NIMH, NIH, Bethesda, MD 20892 USA. [Huang, Larke Nahme; Fisher, Sylvia Kay] Subst Abuse & Mental Hlth Serv Adm, Rockville, MD USA. [McCuan, Ron] Natl Inst Correct, Washington, DC USA. [Trachtenberg, Alan] Indian Hlth Serv, Rockville, MD USA. RP Safran, MA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mail Stop E-44, Atlanta, GA 30333 USA. EM MSafran@cdc.gov NR 40 TC 26 Z9 26 U1 5 U2 9 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 1962 EP 1966 DI 10.2105/AJPH.2009.167346 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900013 PM 19820213 ER PT J AU Lantagne, DS AF Lantagne, Daniele S. TI Viability of Commercially Available Bleach for Water Treatment in Developing Countries SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; DIARRHEA PREVENTION; FLOCCULANT-DISINFECTANT; DRINKING-WATER; SAFE STORAGE AB Treating household water with low-cost, widely available commercial bleach is recommended by some organizations to improve water quality and reduce disease in developing countries. I analyzed the chlorine concentration of 32 bleaches from 12 developing countries; the average error between advertised and measured concentration was 35% (range = -45%-100%; standard deviation = 40%). Because of disparities between advertised and actual concentration, the use of commercial bleach for water treatment in developing countries is not recommended without ongoing quality control testing. (Am J Public Health. 2009;99:1975-1978. doi:10.2105/AJPH.2009.160077) C1 [Lantagne, Daniele S.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lantagne, DS (reprint author), 1600 Clifton Rd,M5-A38, Atlanta, GA 30333 USA. EM dlantagne@cdc.gov FU US Agency for International Development and Population Services International FX Financial support for the technical assistance trips and monitoring equipment was provided by the US Agency for International Development and Population Services International. NR 10 TC 3 Z9 3 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 1975 EP 1978 DI 10.2105/AJPH.2009.160077 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900015 PM 19762657 ER PT J AU Valway, S Jenison, S Keller, N Vega-Hernandez, J McCree, DH AF Valway, Sarah Jenison, Steven Keller, Nick Vega-Hernandez, Jaime McCree, Donna Hubbard TI Risk Assessment and Screening for Sexually Transmitted Infections, HIV, and Hepatitis Virus Among Long-Distance Truck Drivers in New Mexico, 2004-2006 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; SEX WORKERS; PREVALENCE; POPULATION; BEHAVIOR; DISEASES; HIGHWAY; AFRICA; SPREAD AB Objectives. We examined sexually transmitted infection (STI), HIV, and hepatitis virus prevalence and risk behaviors among truck drivers. Methods. We asked participants about their risk behaviors, and we screened them for STIs, HIV, and hepatitis infections. We used logistic regression to identify factors associated with outcomes. Results. Of the 652 enrolled participants, 21% reported sex with sex workers or casual partners in the prior year. Driving solo (odds ratio [OR] = 15.04; 95% confidence interval [CI] = 1.92, 117.53; P = .01), history of injection drug use (IDU; OR = 2.69; 95% CI = 1.19, 6.12; P = .02), and history of an STI (OR = 2.47; 95% CI = 1.19, 5.09; P = .01) were independently associated with high-risk sexual behaviors. Fourteen percent of participants reported drug use in the previous year, and 11% reported having ever injected drugs. Participants tested positive as follows: 54 for HCV antibodies (8.5%), 66 for hepatitis B anticore (anti-HBc) antibodies (10.4%), 8 for chlamydia (1.3%), 1 for gonorrhea (0.2%), 1 for syphilis (0.2%), and 1 for HIV (0.2%). History of injecting drugs (OR = 26.91; 95% CI = 11.61, 62.39; P < .01) and history of anti-HBc antibodies (OR = 7.89; 95% CI = 3.16, 19.68; P < .01) were associated with HCV infection. Conclusions. Our results suggest a need for hepatitis C screening and STI risk-reduction interventions in this population. (Am J Public Health. 2009;99: 2063-2068. doi:10.2105/AJPH.2008.145383) C1 [Valway, Sarah] New Mexico Dept Hlth, Infect Dis Bur, Publ Hlth Div, Santa Fe, NM 87502 USA. [McCree, Donna Hubbard] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. RP Valway, S (reprint author), New Mexico Dept Hlth, Infect Dis Bur, Publ Hlth Div, 1190 S St Francis Dr, Santa Fe, NM 87502 USA. EM s.valway@att.net FU Centers for Disease Control and Prevention through the Association for Prevention Teaching and Research [U36/CCU300860] FX This research was funded by cooperative agreement from the Centers for Disease Control and Prevention through the Association for Prevention Teaching and Research (U36/CCU300860). NR 25 TC 10 Z9 10 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 2063 EP 2068 DI 10.2105/AJPH.2008.145383 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900029 PM 19762674 ER PT J AU Crepaz, N Marshall, KJ Aupont, LW Jacobs, ED Mizuno, Y Kay, LS Jones, P McCree, DH O'Leary, A AF Crepaz, Nicole Marshall, Khiya J. Aupont, Latrina W. Jacobs, Elizabeth D. Mizuno, Yuko Kay, Linda S. Jones, Patricia McCree, Donna Hubbard O'Leary, Ann TI The Efficacy of HIV/STI Behavioral Interventions for African American Females in the United States: A Meta-Analysis SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; SEXUALLY-TRANSMITTED-DISEASES; HIV PREVENTION INTERVENTION; INNER-CITY WOMEN; RISK REDUCTION INTERVENTIONS; HUMAN-IMMUNODEFICIENCY-VIRUS; LOW-INCOME; AIDS-PREVENTION; CONDOM USE; EPIDEMIOLOGIC SYNERGY AB Objectives. We evaluated the efficacy of HIV behavioral interventions for African American females in the United States, and we identified factors associated with intervention efficacy. Methods. We conducted a comprehensive literature review covering studies published from January 1988 to June 2007, which yielded 37 relevant studies. Data were analyzed using mixed-effects models and meta-regression. Results. Overall, behavioral interventions had a significant impact on reductions in HIV-risk sex behaviors (odds ratio [OR]= 0.63; 95% confidence interval [CI] = 0.54, 0.75; n = 11239; Cochrane Q(32) = 84.73; P < .001) and sexually transmitted infections (STIs; OR = 0.81; 95% CI = 0.67, 0.98; n = 8760; Cochrane Q(16) = 22.77; P = .12). Greater intervention efficacy was observed in studies that specifically targeted African American females used gender- or culture-specific materials, used female deliverers, addressed empowerment issues, provided skills training in condom use and negotiation of safer sex, and used role-playing to teach negotiation skills. Conclusions. Behavioral interventions are efficacious at preventing HIV and STIs among African American females. More research is needed to examine the potential contribution of prevention strategies that attend to community-level and structural-level factors affecting HIV infection and transmission in this population. (Am J Public Health. 2009;99:2069-2078. doi:10.2105/AJPH.2008.139519) C1 [Crepaz, Nicole; Marshall, Khiya J.; Aupont, Latrina W.; Jacobs, Elizabeth D.; Mizuno, Yuko; Kay, Linda S.; Jones, Patricia; McCree, Donna Hubbard; O'Leary, Ann] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Prevent Res Branch, Atlanta, GA 30333 USA. RP Crepaz, N (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Prevent Res Branch, 1600 Clifton Rd,Mailstop E-37, Atlanta, GA 30333 USA. EM ncrepaz@cdc.gov NR 84 TC 64 Z9 64 U1 7 U2 10 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2009 VL 99 IS 11 BP 2069 EP 2078 DI 10.2105/AJPH.2008.139519 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511ZD UT WOS:000271209900030 PM 19762676 ER PT J AU Monkongdee, P McCarthy, KD Cain, KP Tasaneeyapan, T Dung, NH Lan, NTN Yen, NTB Teeratakulpisarn, N Udomsantisuk, N Heilig, C Varma, JK AF Monkongdee, Patama McCarthy, Kimberly D. Cain, Kevin P. Tasaneeyapan, Theerawit Dung, Nguyen H. Lan, Nguyen T. N. Yen, Nguyen T. B. Teeratakulpisarn, Nipat Udomsantisuk, Nibondh Heilig, Charles Varma, Jay K. TI Yield of Acid-fast Smear and Mycobacterial Culture for Tuberculosis Diagnosis in People with Human Immunodeficiency Virus SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE tuberculosis; HIV/AIDS; diagnosis; smear; culture; broth ID HIV-ASSOCIATED TUBERCULOSIS; PULMONARY TUBERCULOSIS; GENITOURINARY TUBERCULOSIS; NEGATIVE TUBERCULOSIS; HOSPITALIZED-PATIENTS; INFECTION; THAILAND; DISEASE; LYMPHADENITIS; POPULATION AB Rationale: The World Health Organization recently revised its recommendations for tuberculosis (TB) diagnosis in people with HIV. Most studies cited to support these policies involved HIV-uninfected patients and only evaluated sputum specimens. Objectives: To evaluate the performance of acid-fast bacilli smear and mycobacterial culture on sputum and nonsputum specimens for TB diagnosis in a cross-sectional survey of HIV-infected patients. Methods: In Thailand and Vietnam, we enrolled people with HIV regardless of signs or symptoms. Enrolled patients provided three sputum, one urine, one stool, one blood, and, for patients with palpable peripheral adenopathy, one lymph node aspirate specimen for acid-fast bacilli microscopy and mycobacterial culture on solid and broth-based media. We classified any patient with at least one specimen culture positive for Mycobacterium tuberculosis as having TB. Measurements and Main Results: Of 1,060 patients enrolled, 147 (14%) had TB. Of 126 with pulmonary TB, the incremental yield of performing a third sputum smear over two smears was 2% (95% confidence interval, 0-6), 90 (71%) patients were detected on broth-based culture of the first sputum specimen, and an additional 21 (17%) and 12 (110%) patients were diagnosed with the second and third specimens cultured. Of 82 lymph nodes cultured, 34 (42%) grew M. tuberculosis. In patients with two negative sputum smears, broth-based culture of three sputum specimens had the highest yield of any testing strategy. Conclusions: In people with HIV living in settings where mycobacterial culture is not routinely available to all patients, a third sputum smear adds little to the diagnosis of TB. Broth-based culture of three sputum specimens diagnoses most TB cases, and lymph node aspiration provides the highest incremental yield of any nonpulmonary specimen test for TB. C1 [Monkongdee, Patama; Varma, Jay K.] US CDC Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [McCarthy, Kimberly D.; Cain, Kevin P.; Tasaneeyapan, Theerawit; Heilig, Charles; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Dung, Nguyen H.; Lan, Nguyen T. N.; Yen, Nguyen T. B.] Pham Ngoc Thach Hosp TB & Lung Dis, Ho Chi Minh City, Vietnam. [Teeratakulpisarn, Nipat] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Udomsantisuk, Nibondh] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand. RP Varma, JK (reprint author), US Embassy Beijing, 55 An Jia Lou Rd, Beijing 100600, Peoples R China. EM jvarma@cdc.gov RI Heilig, Charles/C-2753-2008 OI Heilig, Charles/0000-0003-1075-1310 FU U.S. Agency for International Development FX Supported by the U.S. Agency for International Development. NR 43 TC 81 Z9 83 U1 0 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD NOV 1 PY 2009 VL 180 IS 9 BP 903 EP 908 DI 10.1164/rccm.200905-0692OC PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 512AX UT WOS:000271215500016 PM 19628775 ER PT J AU Mixson-Hayden, T Griffing, S Syphard, L Sridaran, S McCollum, A Vinayak, S Villegas, L Barnwell, J Escalante, AA Udhayakumar, V AF Mixson-Hayden, Tonya Griffing, Sean Syphard, Luke Sridaran, Sankar McCollum, Andrea Vinayak, Sumiti Villegas, Leopoldo Barnwell, John Escalante, Ananias A. Udhayakumar, Venkatachalam TI COPY NUMBER VARIATION AND POINT MUTATIONS IN PFMDR1 IN PLASMODIUM FALCIPARUM ISOLATES FROM VENEZUELA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mixson-Hayden, Tonya; Griffing, Sean; Syphard, Luke; Sridaran, Sankar; McCollum, Andrea; Vinayak, Sumiti; Barnwell, John; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Villegas, Leopoldo] Asociac Civil Impacto Social, Tumeremo, Venezuela. [Escalante, Ananias A.] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 3 BP 1 EP 1 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700004 ER PT J AU Vinayak, S Alam, MT Sem, R Shah, NK Susanti, AI Lim, P Muth, S Maguire, JD Rogers, WO Fandeur, T Barnwell, JW Escalante, AA Wongsrichanalai, C Ariey, F Meshnick, SR Udhayakumar, V AF Vinayak, Sumiti Alam, Md Tauqeer Sem, Rithy Shah, Naman K. Susanti, Augustina I. Lim, Pharath Muth, Sinuon Maguire, Jason D. Rogers, William O. Fandeur, Thierry Barnwell, John W. Escalante, Ananias A. Wongsrichanalai, Chansuda Ariey, Frederick Meshnick, Steven R. Udhayakumar, Venkatachalam TI MULTIPLE GENETIC BACKGROUNDS OF THE AMPLIFIED PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE (PFMDR1) GENE AND SELECTIVE SWEEP OF 184F MUTATION IN CAMBODIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Vinayak, Sumiti] Ctr Dis Control & Prevent, Atlanta Res & Educ Fdn, Atlanta, GA USA. [Vinayak, Sumiti; Alam, Md Tauqeer; Barnwell, John W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis,Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Sem, Rithy; Muth, Sinuon] Natl Malaria Ctr, Phnom Penh, Cambodia. [Shah, Naman K.; Meshnick, Steven R.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Susanti, Augustina I.; Maguire, Jason D.; Rogers, William O.; Wongsrichanalai, Chansuda] US Naval Med Res Unit 2, Jakarta, Indonesia. [Lim, Pharath; Ariey, Frederick] Inst Pasteur Cambodia, Phnom Penh, Cambodia. [Fandeur, Thierry] Inst Pasteur, Unite Immunol Mol Parasites, Paris, France. [Escalante, Ananias A.] Arizona State Univ, Sch Life Sci, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 2 BP 1 EP 1 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700003 ER PT J AU Gutman, JR Mulokozi, A Sumari, D Malisa, A Bloland, PB Kachur, SP Abdulla, S MacArthur, JR AF Gutman, Julie R. Mulokozi, Abdunoor Sumari, Deborah Malisa, Allan Bloland, Peter B. Kachur, S. Patrick Abdulla, Salim MacArthur, John R. TI SULFADOXINE-PYRIMETHAMINE, SULFADOXINE-PYRIMETHAMINE plus ARTESUNATE, AND AL FOR UNCOMPLICATED MALARIA INFECTION IN TANZANIA FROM 2004 TO 2006 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Gutman, Julie R.; Bloland, Peter B.; Kachur, S. Patrick; MacArthur, John R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gutman, Julie R.] Emory Univ, Atlanta, GA 30322 USA. [Mulokozi, Abdunoor; Sumari, Deborah; Malisa, Allan; Abdulla, Salim] Ifakara Hlth Res & Dev Ctr, Dar Es Salaam, Tanzania. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 4 BP 2 EP 2 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700005 ER PT J AU Girard, YA Travinsky, B Schotthoefer, A Fedorova, N Eisen, RJ Eisen, L Barbour, AG Lane, RS AF Girard, Yvette A. Travinsky, Bridgit Schotthoefer, Anna Fedorova, Natalia Eisen, Rebecca J. Eisen, Lars Barbour, Alan G. Lane, Robert S. TI UNIQUE POPULATION STRUCTURE OF BORRELIA BURGDORFERI IN THE WESTERN BLACK-LEGGED TICK (IXODES PACIFICUS) IN NORTHERN CALIFORNIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Girard, Yvette A.; Fedorova, Natalia; Lane, Robert S.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Travinsky, Bridgit; Barbour, Alan G.] Univ Calif Irvine, Irvine, CA USA. [Schotthoefer, Anna; Eisen, Rebecca J.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Eisen, Lars] Colorado State Univ, Ft Collins, CO 80523 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 9 BP 3 EP 3 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700010 ER PT J AU Durand, S Cabezas, C Antonio, CA Montoya, MG Montalvan, C McCollum, A Soberon, V Udhayakumar, V Lucas, CM Graf, PC Bacon, DJ AF Durand, Salomon Cabezas, Cesar Alvares Antonio, Carlos Galves Montoya, Mariella Montalvan, Carmen McCollum, Andrea Soberon, Valeria udhayakumar, Venkatachalam Lucas, Carmen M. Graf, Paul C. Bacon, David J. TI EFFICACY OF THREE DIFFERENT REGIMENS OF PRIMAQUINE FOR THE PREVENTION OF RELAPSES OF PLASMODIUM VIVAX MALARIA IN THE AMAZON BASIN OF PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Durand, Salomon; Soberon, Valeria; Lucas, Carmen M.; Graf, Paul C.; Bacon, David J.] Naval Med Res Ctr Detachment, Lima, Peru. [Cabezas, Cesar] Natl Inst Hlth, INS, Lima, Peru. [Alvares Antonio, Carlos; Galves Montoya, Mariella; Montalvan, Carmen] Reg Hlth Directorate Loreto, Iquitos, Peru. [McCollum, Andrea; udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 23 BP 7 EP 7 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700024 ER PT J AU Chase, AJ Medina, FA Munoz-Jordan, JL AF Chase, Amanda J. Medina, Freddy A. Munoz-Jordan, Jorge L. TI INHIBITION OF DOWNSTREAM MEDIATORS OF THE TYPE I INTERFERON RESPONSE IN DENGUE VIRUS INFECTED MONOCYTE-DERIVED DENDRITIC CELLS AND BYSTANDER T CELL ACTIVATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Chase, Amanda J.; Medina, Freddy A.; Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 34 BP 10 EP 10 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700035 ER PT J AU Mathison, BA Montgomery, SP Bishop, HS Johnston, SP Winpisinger, K Brems, R Tsorin, B York, S Sohner, K da Silva, AJ AF Mathison, Blaine A. Montgomery, Susan P. Bishop, Henry S. Johnston, Stephanie P. Winpisinger, Kim Brems, Robert Tsorin, Boris York, Steve Sohner, Kevin da Silva, Alexandre J. TI MESOCESTOIDIASIS: A NEW US CASE AND THE IMPORTANCE OF DIFFERENTIAL DIAGNOSIS IN CESTODE INFECTIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mathison, Blaine A.] Atlanta Educ & Res Fdn, Decatur, GA USA. [Mathison, Blaine A.] Ctr Dis Control & Prevent, CDC, NCZVED, Div Parasit Dis, Atlanta, GA USA. [Winpisinger, Kim] Ohio Dept Hlth, Zoonot Dis Program, Reynoldsburg, OH USA. [Brems, Robert] Muskingum Cty Hlth Dept, Reynoldsburg, OH USA. [Tsorin, Boris; York, Steve; Sohner, Kevin] Ohio State Hlth Lab, Reynoldsburg, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 56 BP 16 EP 16 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700057 ER PT J AU Wilkins, PP Handali, S Lee, YM Noh, J Rodriguez, S Gilman, RH Gonzalez, A Garcia, HH Tsang, VC AF Wilkins, Patricia P. Handali, Sukwan Lee, Yeuk-Mui Noh, John Rodriguez, Silvia Gilman, Robert H. Gonzalez, Armando Garcia, Hector H. Tsang, Victor C. TI THE RELATIVE UTILITY OF RECOMBINANT PROTEINS AND ASSAY FORMATS FOR DETECTION OF CYSTICERCOSIS AND TAENIASIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Wilkins, Patricia P.; Handali, Sukwan; Lee, Yeuk-Mui; Noh, John] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Gilman, Robert H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Gonzalez, Armando] Univ Nacl Mayor San Marcos, Sch Vet Med, Lima 14, Peru. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Inst Nacl Ciencias Neurol, Inst Peruano Parasitol Clin & Expt, Lima, Peru. [Tsang, Victor C.] Georgia State Univ, Atlanta, GA 30303 USA. [Tsang, Victor C.] CDC, Div Parasit Dis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 59 BP 16 EP 17 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700060 ER PT J AU Nygren, BL Omore, R Ombok, M O'Reilly, CE Ochieng, B Moke, F Hightower, AW Kotloff, K Nataro, JP Levine, MM Farag, T Mintz, ED Breiman, RF AF Nygren, Benjamin L. Omore, Richard Ombok, Maurice O'Reilly, Ciara E. Ochieng, Benjamin Moke, Fenny Hightower, Allen W. Kotloff, Karen Nataro, James P. Levine, Myron M. Farag, Tamar Mintz, Eric D. Breiman, Robert F. TI GEOGRAPHIC CHARACTERISTICS OF CHILDREN WITH MODERATE-TO-SEVERE DIARRHEA IN RURAL WESTERN KENYA, 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Nygren, Benjamin L.; O'Reilly, Ciara E.; Mintz, Eric D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Omore, Richard; Ombok, Maurice; Ochieng, Benjamin; Moke, Fenny] Ctr Dis Control & Prevent, Kenya Med Res Inst, Kisumu, Kenya. [Hightower, Allen W.; Breiman, Robert F.] Ctr Dis Control & Prevent, Nairobi, Kenya. [Kotloff, Karen; Nataro, James P.; Levine, Myron M.; Farag, Tamar] Univ Maryland, Baltimore, MD 21201 USA. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 85 BP 24 EP 24 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700086 ER PT J AU Chao, DY Shen, WF Wu, HC Chang, GJ Kao, CL Jwan, SF King, CC AF Chao, Day-Yu Shen, Wen-Fan Wu, Han-Chung Chang, Gwong-Jeng Kao, Chuan-Liang Jwan, Shu-Fan King, Chwan-Chuen TI ANALYSIS OF HUMORAL IMMUNOLOGIC RESPONSE IN MICE IMMUNIZED BY DNA VACCINE ENCODING PRM/E PROTEIN OF DENGUE VIRUS SEROTYPE 2 ADMINISTERED THROUGH GENE GUN AND INTRAMUSCULAR ROUTES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Chao, Day-Yu] Inst Vet Publ Hlth, Taichung, Taiwan. [Shen, Wen-Fan; Wu, Han-Chung] Acad Sinica, Inst Cellular & Organism Biol, Taipei 115, Taiwan. [Chang, Gwong-Jeng] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Kao, Chuan-Liang; Jwan, Shu-Fan] Natl Taiwan Univ, Coll Med, Inst Med Biotechnol, Taipei, Taiwan. [King, Chwan-Chuen] Natl Taiwan Univ, Inst Epidemiol, Coll Publ Hlth, Taipei 10764, Taiwan. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 92 BP 26 EP 26 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700093 ER PT J AU Datagni, G Dorkenoo, A Pearl, E Sodahlon, Y Mathieu, E AF Datagni, Gbati Dorkenoo, Ameyo Pearl, Erika Sodahlon, Yao Mathieu, Els TI A SUSTAINABLE NATIONWIDE LYMPHOEDEMA PROJECT IN TOGO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Datagni, Gbati; Dorkenoo, Ameyo] Minist Sante, Lome, Togo. [Pearl, Erika] IMA Worldhlth, New Windsor, MD USA. [Sodahlon, Yao] Mectizan Donat Program, Atlanta, GA USA. [Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 112 BP 32 EP 32 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700113 ER PT J AU Dorkenoo, A Datagni, GM Morgah, K Mathieu, E Seim, A Sodahlon, Y AF Dorkenoo, Ameyo Datagni, Gbati M. Morgah, Kodjo Mathieu, Els Seim, Anders Sodahlon, Yao TI THE NATIONAL PROGRAM FOR THE ELIMINATION OF LYMPHATIC FILARIASIS IN TOGO: A SUCCESS STORY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Dorkenoo, Ameyo; Datagni, Gbati M.; Morgah, Kodjo] Minist Sante, Lome, Togo. [Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Seim, Anders] Hlth & Dev Int, Fjellstrand, Norway. [Sodahlon, Yao] Mectizan Donat Program, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 114 BP 33 EP 33 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700115 ER PT J AU Dorkenoo, A Mathieu, E Sodahlon, Y AF Dorkenoo, Ameyo Mathieu, Els Sodahlon, Yao TI IS LYMPHATIC FILARIASIS TRANSMISSION INTERRUPTED IN TOGO? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Dorkenoo, Ameyo] Minist Sante, Lome, Togo. [Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sodahlon, Yao] Mectizan Donat Program, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 115 BP 33 EP 33 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700116 ER PT J AU Rawasia, WF Beg, MA Ghanchi, N Sridaran, S Udhayakumar, V AF Rawasia, Wasiq F. Beg, Mohammed Asim Ghanchi, Najia Sridaran, Sankar Udhayakumar, Venkatachalam TI COMMON ORIGIN OF CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND SUBSEQUENT POINT MUTATIONS IN PFCRT1 GENE ASSOCIATED WITH CHLOROQUINE RESISTANCE IN SOUTHERN PAKISTAN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Rawasia, Wasiq F.; Beg, Mohammed Asim; Ghanchi, Najia] Aga Khan Univ, Karachi, Pakistan. [Sridaran, Sankar; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 176 BP 50 EP 50 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700176 ER PT J AU Gire, SK Purkayastha, A Goff, J Olsen, V Damon, I Huggins, J Muyembe, JJ Hensley, L Rubins, K AF Gire, Stephen K. Purkayastha, Anjan Goff, Jay Olsen, Vicki Damon, Inger Huggins, John Muyembe, Jean-Jacque Hensley, Lisa Rubins, Kate TI HUMAN MONKEYPOX GENOMIC DIVERGENCE AND DETERMINANTS OF PATHOGENICITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Gire, Stephen K.; Purkayastha, Anjan; Rubins, Kate] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Goff, Jay; Olsen, Vicki; Huggins, John; Hensley, Lisa] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Damon, Inger] Ctr Dis Control & Prevent, Atlanta, GA USA. [Muyembe, Jean-Jacque] Inst Natl Res Biomed, Kinshasa, Zaire. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 289 BP 81 EP 82 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700289 ER PT J AU Hightower, A Kinkade, C Nguku, P Ksiazek, T Sharif, SK Amwayi, S Schabel, D Feikin, D Ombok, M Njenga, K Breiman, R AF Hightower, Allen Kinkade, Carl Nguku, Patrick Ksiazek, Tom Sharif, S. K. Amwayi, Samuel Schabel, David Feikin, Daniel Ombok, Maurice Njenga, Kariuki Breiman, Robert TI GEOGRAPHIC AND CLIMATOLOGIC RISK FACTORS ASSOCIATED WITH THE 2006-2007 KENYA RIFT VALLEY FEVER OUTBREAK: A POPULATION-BASED MULTIVARIABLE MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Hightower, Allen; Feikin, Daniel; Ombok, Maurice; Njenga, Kariuki; Breiman, Robert] CDC Kenya, Nairobi, Kenya. [Kinkade, Carl] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nguku, Patrick; Sharif, S. K.; Amwayi, Samuel] Minist Publ Hlth, Nairobi, Kenya. [Ksiazek, Tom] Univ Texas Galveston, Med Branch, Galveston, TX 77550 USA. [Schabel, David] USA, Med Res Unit Kenya, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 294 BP 83 EP 83 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700294 ER PT J AU Handali, S Klarman, M Gaspard, AN Noh, J Lee, YM Rodriguez, S Gonzalez, AE Garcia, HH Gilman, R Tsang, VC Wilkins, PP AF Handali, Sukwan Klarman, Molly Gaspard, Amanda N. Noh, John Lee, Yeuk-mui Rodriguez, Silvia Gonzalez, Armando E. Garcia, Hector H. Gilman, Robert Tsang, Victor C. Wilkins, Patricia P. TI A MULTI-ANTIGEN PRINT IMMUNOASSAY (MAPIA) FOR DETECTION OF TAENIA SOLIUM CYSTICERCOSIS AND TAENIASIS ANTIBODIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Handali, Sukwan; Noh, John; Lee, Yeuk-mui; Wilkins, Patricia P.] Ctr Dis Control & Prevent, Chamblee, GA USA. [Klarman, Molly; Gaspard, Amanda N.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Rodriguez, Silvia] Inst Ciencias Neurol, Cysticercosis Unit, Lima, Peru. [Gonzalez, Armando E.] Univ Nacl Mayor San Marcos, Sch Vet Med, Lima 14, Peru. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru. [Gilman, Robert] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Tsang, Victor C.] Georgia State Univ, Dept Biol, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 310 BP 88 EP 88 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700310 ER PT J AU Krolewiecki, AJ Ramanathan, R Fink, V Won, K Cajal, S Juarez, M Acosta, N Lee, R Lammie, P Abraham, D Nutman, T AF Krolewiecki, Alejandro J. Ramanathan, Roshan Fink, Valeria Won, Kimberly Cajal, Silvana Juarez, Marisa Acosta, Norma Lee, Rogan Lammie, Patrick Abraham, David Nutman, Thomas TI EVALUATION OF NEW SEROLOGIC TECHNIQUES FOR THE DIAGNOSIS OF STRONGYLOIDES STERCORALIS INFECTIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Krolewiecki, Alejandro J.; Cajal, Silvana; Juarez, Marisa; Acosta, Norma] Inst Invest Enfermedades Trop, Oran, Argentina. [Ramanathan, Roshan; Nutman, Thomas] NIH, Parasit Dis Lab, Bethesda, MD 20892 USA. [Fink, Valeria] Fdn Huesped, Buenos Aires, DF, Argentina. [Won, Kimberly; Lammie, Patrick] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Lee, Rogan] Westmead Hosp, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia. [Abraham, David] Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 312 BP 89 EP 89 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700312 ER PT J AU Qvarnstrom, Y Bishop, H Teem, J Hollingsworth, R Park, SY Buchholz, A da Silva, AJ AF Qvarnstrom, Yvonne Bishop, Henry Teem, John Hollingsworth, Robert Park, Sarah Y. Buchholz, Arlene da Silva, Alexandre J. TI QUANTITATIVE PCR-BASED ASSESSMENT OF ANGIOSTRONGYLUS CANTONENSIS LARVAE BURDEN IN US ENVIRONMENTAL SAMPLES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Qvarnstrom, Yvonne] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bishop, Henry; da Silva, Alexandre J.] CDC, NCZVED, Div Parasit Dis, Atlanta, GA 30333 USA. [Hollingsworth, Robert] USDA, US Pacific Basin Agr Res Ctr, Hilo, HI USA. [Park, Sarah Y.; Buchholz, Arlene] Hawaii State Dept Hlth, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 313 BP 89 EP 89 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700313 ER PT J AU Cantey, PT Richard, S Richard, S Dorkenoo, A Sodahlon, Y Mathieu, E AF Cantey, Paul T. Richard, Stephanie Richard, Stephanie Dorkenoo, Ameyo Sodahlon, Yao Mathieu, Els TI PATIENT TREATMENT COSTS FOR MANAGEMENT OF LYMPHEDEMA AND ACUTE ATTACKS IN TOGO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Cantey, Paul T.; Mathieu, Els] Ctr Dis Control & Prevent, Div Parasit Dis, NCZVED, Atlanta, GA USA. [Richard, Stephanie] Fogarty Int Ctr, Bethesda, MD USA. [Richard, Stephanie] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Dorkenoo, Ameyo] Togo Natl Program Eliminat Lymphat Filariasis, Lome, Togo. [Sodahlon, Yao] Mectizan Donat Program, Decatur, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 329 BP 94 EP 94 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700329 ER PT J AU Mackenzie, CD Eavey, A Weinkopff, T Lammie, P Geary, T AF Mackenzie, Charles D. Eavey, Allison Weinkopff, Tiffany Lammie, Pat Geary, Timothy TI A RODENT MODEL OF LYMPHATIC PATHOLOGY DUE TO ADULT FILARIAL WORMS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mackenzie, Charles D.; Eavey, Allison] Michigan State Univ, E Lansing, MI 48824 USA. [Weinkopff, Tiffany; Lammie, Pat] Ctr Dis Control & Prevent, Atlanta, GA USA. [Geary, Timothy] McGill Univ, Montreal, PQ, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 331 BP 94 EP 95 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700331 ER PT J AU Arguello, DF Gonzalez-Zeno, G Irizarry-Perez, EB Ramos, M Quinones, L Rivera, A Luxemburger, C Jusot, V Munoz, J Hunsperger, E Sun, W Tomashek, KM AF Argueello, D. Fermin Gonzalez-Zeno, Gladys Irizarry-Perez, E. Brian Ramos, Mary Quinones, Luz Rivera, Aidsa Luxemburger, Christine Jusot, Viviane Munoz, Jorge Hunsperger, Elizabeth Sun, Wellington Tomashek, Kay M. TI WHAT IS ENHANCED SURVEILLANCE? DESCRIPTION OF AN ENHANCE DENGUE SURVEILLANCE SYSTEM MODEL - THE PATILLAS ENHANCED DENGUE SURVEILLANCE SYSTEM (PEDSS), PATILLAS PUERTO RICO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Argueello, D. Fermin; Gonzalez-Zeno, Gladys; Irizarry-Perez, E. Brian; Quinones, Luz; Rivera, Aidsa; Munoz, Jorge; Hunsperger, Elizabeth; Tomashek, Kay M.] Ctr Dis Control & Prevent, San Juan, PR USA. [Ramos, Mary] Univ New Mexico, Dept Pediat, Albuquerque, NM 87131 USA. [Luxemburger, Christine; Jusot, Viviane] Sanofi Pasteur, Lyon, France. [Sun, Wellington] US FDA, Rockville, MD 20857 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 354 BP 101 EP 101 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700354 ER PT J AU Black, CL Muok, EM Carter, JM Mwinzi, PN Karanja, DM Secor, WE Colley, DG AF Black, Carla L. Muok, Erick M. Carter, Jennifer M. Mwinzi, Pauline N. Karanja, Diana M. Secor, W. Evan Colley, Daniel G. TI INCREASES IN SCHISTOSOME-SPECIFIC IGE AND CD19+/CD23+B CELLS IN A COHORT OF KENYAN CHILDREN UNDERGOING REPEATED TREATMENT AND REINFECTION WITH SCHISTOSOMA MANSONI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Black, Carla L.; Carter, Jennifer M.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Muok, Erick M.; Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 381 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700381 ER PT J AU Barban, V Girerd, Y Arnaud-Barbe, N Mantel, N Gulia, S Munoz-Jordan, JL Dumas, R AF Barban, Veronique Girerd, Yves Arnaud-Barbe, Nadege Mantel, Nathalie Gulia, Sandrine Munoz-Jordan, Jorge L. Dumas, Rafaele TI EVALUATION OF NEUTRALIZING ANTIBODY RESPONSES AGAINST A LARGE RANGE OF WILD-TYPE ISOLATES IN SERA OF PRIMATES VACCINATED WITH A TETRAVALENT DENGUE VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Barban, Veronique; Girerd, Yves; Arnaud-Barbe, Nadege; Mantel, Nathalie; Gulia, Sandrine; Dumas, Rafaele] Sanofi Pasteur, Marcy Letoile, France. [Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 394 BP 113 EP 113 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700394 ER PT J AU Kinney, RM Brewoo, JN Arguello, JJ Shilengo, SJ Powell, TD Partidos, CD Bowen, RA Luy, B Butrapet, S Huang, CYH Stinchcomb, DT Osorio, JE AF Kinney, Richard M. Brewoo, Joseph N. Arguello, John J. Shilengo, Shawn J. Powell, Tim D. Partidos, Charalambos D. Bowen, Richard A. Luy, Betty Butrapet, Siritorn Huang, Claire Y. -H. Stinchcomb, Dan T. Osorio, Jorge E. TI CLINICAL AND PRECLINICAL EVALUATION OF DENVAX, A TETRAVALENT DEN-2 PDK-53-BASED CHIMERIC DENGUE VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kinney, Richard M.; Arguello, John J.; Shilengo, Shawn J.; Powell, Tim D.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA. [Brewoo, Joseph N.; Partidos, Charalambos D.] Inviragen Inc, Madison, WI USA. [Bowen, Richard A.] Colorado State Univ, Ft Collins, CO 80523 USA. [Luy, Betty; Butrapet, Siritorn; Huang, Claire Y. -H.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Osorio, Jorge E.] Univ Wisconsin, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 393 BP 113 EP 113 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700393 ER PT J AU Beatty, ME Beutels, P Meltzer, MI Wichmann, O Hombach, J Hutubessy, R Dessis, D Coudeville, L Dervaux, B Shepard, DS Margolis, HS Kuritsky, J AF Beatty, Mark E. Beutels, Philippe Meltzer, Martin I. Wichmann, Ole Hombach, Joachim Hutubessy, Raymond Dessis, Damien Coudeville, Laurent Dervaux, Benoit Shepard, Donald S. Margolis, Harold S. Kuritsky, Joel TI A SYSTEMATIC LITERATURE REVIEW AND EXPERT PANEL'S ASSESSMENT HEALTH ECONOMICS OF DENGUE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Beatty, Mark E.; Wichmann, Ole; Margolis, Harold S.; Kuritsky, Joel] Int Vaccine Inst, Seoul, South Korea. [Beutels, Philippe] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium. [Meltzer, Martin I.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hombach, Joachim; Hutubessy, Raymond] WHO, CH-1211 Geneva, Switzerland. [Dessis, Damien] GlaxoSmithKline Biol, Wavre, Belgium. [Coudeville, Laurent] Sanofi Pasteur, Lyon, France. [Dervaux, Benoit] Univ Catholique Lille, Lille, France. [Shepard, Donald S.] Brandeis Univ, Waltham, MA USA. RI Dervaux, Benoit/A-7161-2014; Beutels, Philippe/A-1919-2010 OI Beutels, Philippe/0000-0001-5034-3595 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 399 BP 115 EP 115 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700399 ER PT J AU Gershman, M Schroeder, B Ostroff, S Lurie, P Lamias, M Han, P Ferraro, A Kozarsky, P Marano, N AF Gershman, Mark Schroeder, Betsy Ostroff, Steve Lurie, Perrianne Lamias, Mark Han, Pauline Ferraro, Aimee Kozarsky, Phyllis Marano, Nina TI KNOWLEDGE AND PRACTICES AMONG YELLOW FEVER VACCINE PROVIDERS AND CLINICS, PENNSYLVANIA, USA, 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Gershman, Mark; Schroeder, Betsy; Lamias, Mark; Han, Pauline; Kozarsky, Phyllis; Marano, Nina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ostroff, Steve; Lurie, Perrianne; Ferraro, Aimee] Penn Dept Hlth, Harrisburg, PA 17108 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 401 BP 115 EP 115 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700401 ER PT J AU Schroeder, B Gershman, M Ostroff, S Lurie, P Lamias, M Han, P Ferraro, A Kozarsky, P Marano, N AF Schroeder, Betsy Gershman, Mark Ostroff, Stephen Lurie, Perianne Lamias, Mark Han, Pauline Ferraro, Aimee Kozarsky, Phyllis Marano, Nina TI AN ON-SITE SURVEY OF YELLOW FEVER VACCINATION CLINIC PRACTICES, PENNSYLVANIA, USA, 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Schroeder, Betsy; Gershman, Mark; Lamias, Mark; Han, Pauline; Kozarsky, Phyllis; Marano, Nina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ostroff, Stephen; Lurie, Perianne; Ferraro, Aimee] Penn Dept Hlth, Harrisburg, PA 17108 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 406 BP 117 EP 117 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700406 ER PT J AU Levin, ML Roche, AJ Killmaster, LF Zemtsova, GE Nicholson, WL AF Levin, Michael L. Roche, Aubree J. Killmaster, Lindsay F. Zemtsova, Galina E. Nicholson, William L. TI INABILITY OF AMBLYOMMA AMERICANUM LARVAE TO ACQUIRE EHRLICHIA CHAFFEENSIS FROM AN INFECTED DOG SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Levin, Michael L.; Roche, Aubree J.; Killmaster, Lindsay F.; Zemtsova, Galina E.; Nicholson, William L.] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 413 BP 118 EP 119 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700413 ER PT J AU Dasch, GA Eremeeva, ME Robinson, LK Dirks, K White, FH Zambrano, ML Kato, C Tang, K Bruce, DC Munk, AC Detter, JC Brettin, TS AF Dasch, Gregory A. Eremeeva, Marina E. Robinson, Lauren K. Dirks, Kathryn White, Frankie H. Zambrano, Maria L. Kato, Cecilia Tang, Kevin Bruce, David C. Munk, A. Chris Detter, J. Chris Brettin, Thomas S. TI GENETIC RELATIONSHPS OF 364D AND HLP#2 SEROTYPES TO RICKETTSIA RICKETTSII SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Dasch, Gregory A.; Eremeeva, Marina E.; Robinson, Lauren K.; Dirks, Kathryn; White, Frankie H.; Zambrano, Maria L.; Kato, Cecilia; Tang, Kevin] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bruce, David C.; Munk, A. Chris; Detter, J. Chris; Brettin, Thomas S.] Los Alamos Natl Lab, Joint Genome Inst, Los Alamos, NM USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 414 BP 119 EP 119 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700414 ER PT J AU Reisenman, CE Lawrence, GG Guerenstein, PG Gregory, T Dotson, EM Hildebrand, JG AF Reisenman, Carolina E. Lawrence, Gena G. Guerenstein, Pablo G. Gregory, Teresa Dotson, Ellen M. Hildebrand, John G. TI INFECTION RATES OF THE TRIATOMINE BUG TRIATOMA RUBIDA WITH TRYPANOSOMA CRUZI, THE CAUSATIVE AGENT OF CHAGAS DISEASE, IN THE TUCSON AREA OF ARIZONA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Reisenman, Carolina E.; Guerenstein, Pablo G.; Gregory, Teresa; Hildebrand, John G.] Univ Arizona, Arizona Res Labs, Tucson, AZ USA. [Lawrence, Gena G.; Dotson, Ellen M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 419 BP 120 EP 120 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700419 ER PT J AU Arguello, DF Quinones, L Tomashek, K Beltran, M Acosta, L Acosta, H Cano, P Garcia, E Pollissard, L Luxemburger, C Hunsperger, E AF Argueello, D. Fermin Quinones, Luz Tomashek, Kay Beltran, Manuela Acosta, Luz Acosta, Heidi Cano, Patricia Garcia, Enid Pollissard, Laurence Luxemburger, Christine Hunsperger, Elizabeth TI DENGUE INFECTION AMONG SCHOOL-AGED CHILDREN AND ADOLESCENTS IN PATILLAS, PUERTO RICO: RESULTS OF A PROSPECTIVE SEROTYPE-SPECIFIC INCIDENCE STUDY, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Argueello, D. Fermin; Quinones, Luz; Tomashek, Kay; Beltran, Manuela; Acosta, Luz; Acosta, Heidi; Hunsperger, Elizabeth] Ctr Dis Control & Prevent, San Juan, PR USA. [Cano, Patricia; Garcia, Enid] Puerto Rico Dept Hlth, San Juan, PR USA. [Pollissard, Laurence; Luxemburger, Christine] Sanofi Pasteur, Lyon, France. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 440 BP 126 EP 126 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700440 ER PT J AU Calderon-Squiabro, JM Pena-Orellana, M Arguello, F Dayan, G Tomashek, K AF Calderon-Squiabro, Jose M. Pena-Orellana, Marisol Arguello, Fermin Dayan, Gustavo Tomashek, Kay TI MUNICIPALITIES IN PUERTO RICO WITH HISTORY OF HIGH INCIDENCE RATES OF DENGUE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Calderon-Squiabro, Jose M.; Pena-Orellana, Marisol; Arguello, Fermin; Tomashek, Kay] Ctr Dis Control & Prevent, San Juan, PR USA. [Dayan, Gustavo] Sanofi Pasteur, Swiftwater, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 439 BP 126 EP 126 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700439 ER PT J AU Robinson, JS Lanciotti, RS Fischer, M Featherstone, D Vasanthapuram, R Desai, A Ramamurty, N Chowdhury, AH Sandhu, H Cavallaro, KF Johnson, BW AF Robinson, Jaimie S. Lanciotti, Robert S. Fischer, Marc Featherstone, David Vasanthapuram, Ravi Desai, Anita Ramamurty, Nalini Chowdhury, Anwarul Haque Sandhu, Hardeep Cavallaro, Kathleen F. Johnson, Barbara W. TI DENGUE MENINGOENCEPHALITIS IN INDIA AND BANGLADESH SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Robinson, Jaimie S.; Lanciotti, Robert S.; Fischer, Marc; Johnson, Barbara W.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Featherstone, David] WHO, CH-1211 Geneva, Switzerland. [Vasanthapuram, Ravi; Desai, Anita] NIMHANS, Bangalore, Karnataka, India. [Ramamurty, Nalini] WHO, SEARO, New Delhi, India. [Chowdhury, Anwarul Haque] IPH, Dhaka, Bangladesh. [Sandhu, Hardeep; Cavallaro, Kathleen F.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 443 BP 127 EP 127 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700443 ER PT J AU Amann, J Brooks, J Miri, E Eigege, A Dogonyaro, P McFarland, D Richards, F AF Amann, Josef Brooks, Janna Miri, Emmanual Eigege, Abel Dogonyaro, Priscillia McFarland, Deb Richards, Frank TI STRENGTHENING MANAGEMENT CAPACITY OF PERSONNEL INVOLVED IN INTEGRATED INTERVENTIONS FOR NEGLECTED TROPICAL DISEASE (NTD) TO SUPPORT A MORE EFFECTIVE END EFFICIENT DELIVERY OF INTEGRATED INTERVENTIONS IN THE NIGERIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Amann, Josef; Brooks, Janna] Ctr Dis Control & Prevent, Atlanta, GA USA. [Miri, Emmanual; Eigege, Abel; Dogonyaro, Priscillia] Carter Ctr, Jos, Nigeria. [Richards, Frank] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 448 BP 128 EP 129 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700448 ER PT J AU Romoser, MA Buzzanell, PM Harter, LM Kreps, GL Singhal, A Zielinski-Gutierrez, E AF Romoser, Margaret Ann Buzzanell, Patrice M. Harter, Lynn M. Kreps, Gary L. Singhal, Arvind Zielinski-Gutierrez, Emily TI THE ROLE OF COMMUNICATION SCHOLARSHIP IN THE PREVENTION AND CONTROL OF DISEASES OF GLOBAL IMPORT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Romoser, Margaret Ann; Harter, Lynn M.] Ohio Univ, Athens, OH 45701 USA. [Buzzanell, Patrice M.] Purdue Univ, W Lafayette, IN 47907 USA. [Kreps, Gary L.] George Mason, Fairfax, VA USA. [Singhal, Arvind] Univ Texas El Paso, El Paso, TX 79968 USA. [Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 457 BP 131 EP 131 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700457 ER PT J AU Bishop, H Mathison, BA Johnston, SP Jones, JL Eberhard, ML Bandea, R Pieniazek, NJ da Silva, AJ AF Bishop, Henry Mathison, Blaine A. Johnston, Stephanie P. Jones, Jeffrey L. Eberhard, Mark L. Bandea, Rebecca Pieniazek, Norman J. da Silva, Alexandre J. TI ACCIDENTAL FINDING OF A LIVE ANISAKID NEMATODE (ASCARIDIDA: HETEROCHEILIDAE) IN FRESH MARKET COD FISH FROM AN ATLANTA GROCERY STORE AND ITS IMPLICATION IN PUBLIC HEALTH SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mathison, Blaine A.; Bandea, Rebecca] Ctr Dis Control & Prevent, CDC NCZVED Div Parasit Dis, Atlanta, GA USA. [Mathison, Blaine A.; Bandea, Rebecca] Atlanta Educ & Res Fdn, Decatur, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 466 BP 133 EP 133 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700465 ER PT J AU Diawara, A Kaplan, R Lammie, P Prichard, R AF Diawara, Aissatou Kaplan, Ray Lammie, Patrick Prichard, Roger TI INTENSITY AND PREVALENCE OF SOIL TRANSMITTED HELMINTHS IN HAITIAN COMMUNITIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Diawara, Aissatou; Prichard, Roger] McGill Univ, Montreal, PQ, Canada. [Kaplan, Ray] Univ Georgia, Athens, GA 30602 USA. [Lammie, Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 464 BP 133 EP 133 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700464 ER PT J AU Ong, S Owens, SM Chenine, AL Ruprecht, RM Secor, WE AF Ong, SuFey Owens, S. Michele Chenine, Agnes L. Ruprecht, Ruth M. Secor, W. Evan TI DECREASED ANTIVIRAL ANTIBODY RESPONSES IN SHIV1157IP-INFECTED RHESUS MACAQUES COINFECTED WITH SCHISTOSOMA MANSONI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Ong, SuFey; Owens, S. Michele; Secor, W. Evan] Ctr Dis Control, Atlanta, GA 30333 USA. [Chenine, Agnes L.; Ruprecht, Ruth M.] Harvard Univ, Cambridge, MA 02138 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 475 BP 135 EP 136 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700474 ER PT J AU Delgado, S Neyra, RC Machaca, VRQ Juarez, JA Verastegui, M Bocangel, CD Comrie, A Naquira, C del Carpio, JGC Gilman, RH Bern, C Levy, MZ AF Delgado, Stephen Castillo Neyra, Ricardo Quispe Machaca, Victor R. Ancca Juarez, Jenny Verastegui, Manuela Bocangel, Cesar D. Comrie, Andrew Naquira, Cesar Cornejo del Carpio, Juan G. Gilman, Robert H. Bern, Caryn Levy, Michael Z. TI SPATIO-TEMPORAL PERSPECTIVES ON PREVALENCE OF TRYPANOSOMA CRUZI INFECTION IN PERI-URBAN AREQUIPA, PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Delgado, Stephen; Comrie, Andrew] Univ Arizona, Tucson, AZ USA. [Castillo Neyra, Ricardo; Quispe Machaca, Victor R.; Ancca Juarez, Jenny; Verastegui, Manuela; Bocangel, Cesar D.; Naquira, Cesar] Univ Peruana Cayetano Heredia, Lima, Peru. [Cornejo del Carpio, Juan G.] Minist Salud, Direcc Reg, Arequipa, Peru. [Gilman, Robert H.] Johns Hopkins Univ, Baltimore, MD USA. [Bern, Caryn] Ctr Dis Control & Prevent, Atlanta, GA USA. [Levy, Michael Z.] Fogarty Int Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 484 BP 138 EP 138 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700483 ER PT J AU da Costa, GC Lery, LS Moura, H von Kruger, VM Peralta, RH Barr, JR Peralta, M AF da Costa, Giovani C. Lery, Leticia S. Moura, Hercules von Kruger, Vanda M. Peralta, Regina H. Barr, John R. Peralta, M. TI COMPARATIVE PROTEOMIC ANALYSIS OF IMMUNODOMINANT 30-34 KDA PROTEINS OF TRYPANOSOMA CRUZI BY DIFFERENT MASS SPECTROMETRY METHODS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [da Costa, Giovani C.; Lery, Leticia S.; von Kruger, Vanda M.; Peralta, M.] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. [Moura, Hercules; Barr, John R.] Ctr Dis Control, Atlanta, GA 30333 USA. [Peralta, Regina H.] Univ Fed Fluminense, Niteroi, RJ, Brazil. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 495 BP 141 EP 141 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700493 ER PT J AU Ramey, KI Kucerova, Z Thompson, W Stiles, JK AF Ramey, Kiantra I. Kucerova, Zuzana Thompson, Winston Stiles, Jonathan K. TI EVALUATION OF INHIBITORY EFFECT OF A TRYPANOSOMA BRUCEI CALCIUM CHANNEL ANTIBODY (ANTI-TBCC1) IN VITRO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Ramey, Kiantra I.; Thompson, Winston; Stiles, Jonathan K.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Kucerova, Zuzana] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 497 BP 141 EP 141 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700495 ER PT J AU Durand, S Santolalla, M Salas, C Soberon, V Antonio, CA Montalvan, C Montoya, MG McCollum, A Green, MD Lucas, C Udhayakumar, V Graf, PC Bacon, DJ AF Durand, Salomon Santolalla, Meddly Salas, Carola Soberon, Valeria Alvares Antonio, Carlos Montalvan, Carmen Galves Montoya, Mariella McCollum, Andrea Green, Michael D. Lucas, Carmen Udhayakumar, Venkatachalam Graf, Paul C. Bacon, David J. TI A PROBABLE CASE OF CHLOROQUINE-RESISTANT PLASMODIUM VIVAX IN THE PERUVIAN AMAZON SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Durand, Salomon; Santolalla, Meddly; Salas, Carola; Soberon, Valeria; Lucas, Carmen; Graf, Paul C.] Naval Med Res Ctr Detachment, Lima, Peru. [Alvares Antonio, Carlos; Montalvan, Carmen; Galves Montoya, Mariella] Reg Hlth Directorate, Loreto, Peru. [McCollum, Andrea; Green, Michael D.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bacon, David J.] USN, Environm & Preventat Med Unit 2, Norfolk, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 529 BP 150 EP 150 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700527 ER PT J AU Hwang, J Graves, PM Reithinger, R Getachew, A Bilak, H Shargie, EB Ngondi, J Lungu, C Mosher, A Gebre, T Wolkon, A Tenaw, E Kachur, SP Jima, D AF Hwang, Jimee Graves, Patricia M. Reithinger, Richard Getachew, Asefaw Bilak, Hana Shargie, Estifanos Biru Ngondi, Jeremiah Lungu, Chris Mosher, Aryc Gebre, Teshome Wolkon, Adam Tenaw, Eskindir Kachur, S. Patrick Jima, Daddi TI MOTHER'S KNOWLEDGE OF MALARIA PREDICTS ITN USE AND FEVER TREATMENT IN CHILDREN UNDER FIVE YEARS - MALARIA INDICATOR SURVEY, ETHIOPIA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Hwang, Jimee; Wolkon, Adam; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. [Graves, Patricia M.; Mosher, Aryc] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Reithinger, Richard] US Agcy Int Dev, Addis Ababa, Ethiopia. [Getachew, Asefaw; Bilak, Hana; Lungu, Chris] PATH, Seattle, WA USA. [Shargie, Estifanos Biru; Gebre, Teshome] Carter Ctr, Addis Ababa, Ethiopia. [Ngondi, Jeremiah] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. [Tenaw, Eskindir] Cent Stat Agcy, Addis Ababa, Ethiopia. [Jima, Daddi] Minist Hlth, Dis Prevent & Control Dept, Addis Ababa, Ethiopia. RI Graves, Patricia/J-8691-2014 OI Graves, Patricia/0000-0002-5215-3901 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 538 BP 153 EP 153 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956700536 ER PT J AU Vazquez-Prokopec, GM Eng, JV Kelly, R Mead, D Kolhe, P Chaves, LF Burkot, T Kitron, U AF Vazquez-Prokopec, Gonzalo M. Eng, Jodi Vanden Kelly, Rosmarie Mead, Daniel Kolhe, Priti Chaves, Luis F. Burkot, Thomas Kitron, Uriel TI SPATIAL CLUSTERING OF WEST NILE VIRUS INFECTION IS ASSOCIATED WITH COMBINED SEWER OVERFLOW CREEKS IN URBAN ATLANTA, GEORGIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Vazquez-Prokopec, Gonzalo M.; Chaves, Luis F.; Kitron, Uriel] Emory Univ, Atlanta, GA 30322 USA. [Eng, Jodi Vanden; Burkot, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kelly, Rosmarie] Georgia Div Publ Hlth, Atlanta, GA USA. [Mead, Daniel] Univ Georgia, Athens, GA 30602 USA. [Kolhe, Priti] Fulton Cty Dept Hlth & Wellness, Atlanta, GA USA. RI Chaves, Luis Fernando/F-3448-2010 OI Chaves, Luis Fernando/0000-0002-5301-2764 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 589 BP 168 EP 168 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701005 ER PT J AU Dasch, GA White, FH Eremeeva, ME Tang, K Bruce, DC Munk, AC Detter, JC Brettin, TS AF Dasch, Gregory A. White, Frankie H. Eremeeva, Marina E. Tang, Kevin Bruce, David C. Munk, A. Chris Detter, J. Chris Brettin, Thomas S. TI GENETIC RELATIONSHIPS AMONG THREE FAMILIES OF PLASMIDS IN RICKETTSIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Dasch, Gregory A.; White, Frankie H.; Eremeeva, Marina E.; Tang, Kevin] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bruce, David C.; Munk, A. Chris; Detter, J. Chris; Brettin, Thomas S.] Los Alamos Natl Lab, Joint Genome Inst, Los Alamos, NM USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 616 BP 175 EP 176 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701032 ER PT J AU Bandea, R Ndubuisi, M Daniell, C DiMiceli, L Park, M da Silva, AJ AF Bandea, Rebecca Ndubuisi, Mackevin Daniell, Cyndy DiMiceli, Lauren Park, Mahin da Silva, Alexandre J. TI EVALUATION OF STOOL FIXATIVES FOR MOLECULAR DIAGNOSTIC DETECTION OF GIARDIA INTESTINALIS, ENTAMOEBA HISTOLYTICA AND ENTAMOEBA DISPAR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bandea, Rebecca] CDC, NCZVED, Div Parasit Dis & Atlanta Res & Educ Fdn, Atlanta, GA 30333 USA. [Ndubuisi, Mackevin; Daniell, Cyndy; DiMiceli, Lauren; Park, Mahin] Georgia Dept Hlth, Atlanta, GA USA. [da Silva, Alexandre J.] CDC, NCZVED, Div Parasit Dis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 621 BP 177 EP 177 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701037 ER PT J AU Johnston, SP Bishop, HS Mathison, BA Jones, JL Roberts, J da Silva, AJ AF Johnston, Stephanie P. Bishop, Henry S. Mathison, Blaine A. Jones, Jeffrey L. Roberts, Jacquelin da Silva, Alexandre J. TI DIAGNOSTIC PARASITOLOGY TRAINING: CDC DPDX TRAINING PROJECT 2006-2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Johnston, Stephanie P.; Bishop, Henry S.; Mathison, Blaine A.; Jones, Jeffrey L.; Roberts, Jacquelin; da Silva, Alexandre J.] CDC, NCZVED, Div Parasit Dis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 627 BP 179 EP 179 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701043 ER PT J AU Shane, HL Verani, JR Abudho, B Montgomery, SP Jolly, AK Mwinzi, PM Butler, SE Colley, DG Karanja, DM Secor, WE AF Shane, Hillary L. Verani, Jennifer R. Abudho, Bernard Montgomery, Susan P. Jolly, Anna K. Mwinzi, Pauline M. Butler, Sara E. Colley, Daniel G. Karanja, Diana M. Secor, W. Evan TI COMPARISON OF TWO COMMERCIALLY AVAILABLE URINE CCA ASSAYS FOR THE DETECTION OF S. MANSONI INFECTION IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Shane, Hillary L.; Verani, Jennifer R.; Montgomery, Susan P.; Jolly, Anna K.; Butler, Sara E.; Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Abudho, Bernard; Mwinzi, Pauline M.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Colley, Daniel G.] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA. [Colley, Daniel G.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 634 BP 181 EP 181 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701050 ER PT J AU Mitchell, T Painter, J Armstrong, G Wasley, A Hu, D Phares, C Weinberg, M AF Mitchell, Tarissa Painter, John Armstrong, Gregory Wasley, Annemarie Hu, Dale Phares, Christina Weinberg, Michelle TI THE INCREASING DISEASE BURDEN OF IMPORTED CHRONIC HEPATITIS B VIRUS INFECTION_UNITED STATES, 1973-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Mitchell, Tarissa; Painter, John; Armstrong, Gregory; Wasley, Annemarie; Hu, Dale; Phares, Christina; Weinberg, Michelle] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 645 BP 184 EP 184 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701061 ER PT J AU Barnett, ED Drobeniuc, J Kamili, S Hamer, DH Chen, L MacLeod, W Marano, N Kogelman, L Ooi, WW Yanni, E Karchmer, AW Benoit, C Wilson, ME AF Barnett, Elizabeth Day Drobeniuc, Jan Kamili, Saleem Hamer, Davidson H. Chen, Lin MacLeod, William Marano, Nina Kogelman, Laura Ooi, Winnie W. Yanni, Emad Karchmer, A. W. Benoit, Christine Wilson, Mary E. TI ANTIBODY TO HEPATITIS E VIRUS IN TRAVELERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Barnett, Elizabeth Day; Hamer, Davidson H.; Benoit, Christine] Boston Med Ctr, Boston, MA USA. [Drobeniuc, Jan; Kamili, Saleem; Marano, Nina; Yanni, Emad] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chen, Lin] Mt Auburn Hosp, Cambridge, MA USA. [MacLeod, William] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Kogelman, Laura] Tufts Med Ctr, Boston, MA USA. [Ooi, Winnie W.] Lahey Clin Fdn, Burlington, MA USA. [Karchmer, A. W.] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Wilson, Mary E.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 650 BP 185 EP 186 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701066 ER PT J AU Kahn, G Cabrera, L Verastegui, M Ortega, YR Gilman, RH Xiao, LH Cama, VA AF Kahn, Geoffrey Cabrera, Lilia Verastegui, Manuela Ortega, Ynes R. Gilman, Robert H. Xiao, Lihua Cama, Vitaliano A. TI RELATIONSHIP BETWEEN SOCIO-ECONOMIC FACTORS AND TIME-TO-INFECTION WITH GIARDIA INTESTINALIS AMONG CHILDREN IN PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kahn, Geoffrey; Xiao, Lihua; Cama, Vitaliano A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Cabrera, Lilia] Asociac Benef Prisma, Lima, Peru. [Verastegui, Manuela] Univ Peruana Cayetano Heredia, Lima, Peru. [Ortega, Ynes R.] Univ Georgia, Griffin, GA USA. [Gilman, Robert H.] Johns Hopkins Univ, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 658 BP 188 EP 188 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701074 ER PT J AU Weinkopff, TS Lammie, P AF Weinkopff, Tiffany S. Lammie, Patrick TI STIMULATION OF MONOCYTES BY FILARIAL EXCRETORY-SECRETORY PRODUCTS: A POTENTIAL ROLE IN MODULATION OF THE LYMPHATIC ENDOTHELIUM? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Weinkopff, Tiffany S.] Univ Georgia, Athens, GA 30602 USA. [Lammie, Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 659 BP 188 EP 188 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701075 ER PT J AU Sandison, T Homsy, J Arinaitwe, E Vora, N Kakuru, A Wanzira, H Bigira, V Kalamya, J Kamya, M Dorsey, G Tappero, J AF Sandison, Taylor Homsy, Jaco Arinaitwe, Emmanuel Vora, Neil Kakuru, Abel Wanzira, Humphrey Bigira, Victor Kalamya, Julius Kamya, Moses Dorsey, Grant Tappero, Jordan TI A RANDOMIZED CLINICAL TRIAL OF THE PROTECTIVE EFFICACY OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS AGAINST MALARIA IN HIV-EXPOSED CHILDREN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Sandison, Taylor] Univ Washington, Seattle, WA 98195 USA. [Homsy, Jaco; Kalamya, Julius] Ctr Dis Control Uganda, PMTCT Program, Entebbe, Uganda. [Arinaitwe, Emmanuel; Kakuru, Abel; Wanzira, Humphrey; Bigira, Victor] Infect Dis Res Collaborat, Kampala, Uganda. [Vora, Neil; Dorsey, Grant] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Kamya, Moses] Makerere Univ, Kampala, Uganda. [Tappero, Jordan] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 190 EP 190 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701079 ER PT J AU Skarbinski, J Lyimo, T Rwebogora, F McElroy, P Abdulla, S Kachur, SP Kahigwa, E AF Skarbinski, Jacek Lyimo, Thomas Rwebogora, Faustin McElroy, Peter Abdulla, Salim Kachur, S. Patrick Kahigwa, Elizeus TI SEVERE DISEASE IN CHILDREN PACKAGE: IMPROVING CARE FOR CHILDREN WITH VERY SEVERE FEBRILE DISEASE PRESENTING TO FIRST-LEVEL HEALTH FACILITIES IN TANZANIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Skarbinski, Jacek; McElroy, Peter; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lyimo, Thomas; Rwebogora, Faustin; Abdulla, Salim; Kahigwa, Elizeus] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 190 EP 190 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701080 ER PT J AU Singh, N Singh, MP Wylie, BJ Shukla, MM Hussain, M Dash, AP Yeboah-Antwi, K Sabin, L Udhayakumar, V Desai, M Hamer, DH AF Singh, Neeru Singh, Mrigendra P. Wylie, Blair J. Shukla, Manmohan M. Hussain, Mobassir Dash, Aditya P. Yeboah-Antwi, Kojo Sabin, Lora Udhayakumar, Venkatachalam Desai, Meghna Hamer, Davidson H. TI BURDEN OF MALARIA IN PREGNANCY IN WOMEN PRESENTING TO DELIVERY UNITS IN AREAS WITH STABLE AND UNSTABLE MALARIA TRANSMISSION IN CHHATTISGARH, INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Singh, Neeru] Reg Med Res Ctr ICMR, Jabalpur, India. [Singh, Mrigendra P.; Shukla, Manmohan M.; Hussain, Mobassir] Natl Inst Malaria Res Field Stn, Jabalpur, India. [Wylie, Blair J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Dash, Aditya P.] Natl Inst Malaria Res, Delhi, India. [Yeboah-Antwi, Kojo; Sabin, Lora] Boston Univ, Ctr Int Hlth & Dev, Boston, MA 02215 USA. [Udhayakumar, Venkatachalam; Desai, Meghna] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 191 EP 191 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701082 ER PT J AU McMorrow, M Masanja, I Kahigwa, E Abdulla, SM Kachur, SP AF McMorrow, Meredith Masanja, Irene Kahigwa, Elizeus Abdulla, Salim M. Kachur, S. Patrick TI HIGH SENSITIVITY OF RAPID DIAGNOSTIC TESTS FOR MALARIA IN ROUTINE PATIENT CARE IN RURAL TANZANIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [McMorrow, Meredith; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. [Masanja, Irene; Kahigwa, Elizeus; Abdulla, Salim M.] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 194 EP 194 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701092 ER PT J AU Khan, MS Gurley, ES Hossain, MJ Nahar, N Luby, SP AF Khan, M. S. Gurley, Emily S. Hossain, Md. Jahangir Nahar, Nazmun Luby, Stephen P. TI PREVENTING NIPAH VIRUS TRANSMISSION: UNDERSTANDING EFFICACY OF BAMBOO SKIRT TO IMPEDE DATE PALM SAP CONTAMINATION BY BATS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Khan, M. S.; Gurley, Emily S.; Hossain, Md. Jahangir; Nahar, Nazmun] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 687 BP 197 EP 197 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701103 ER PT J AU Kennedy, ED Philius, G Direny, AN Desir, L Vely, JF Streit, TG Mathieu, E AF Kennedy, Erin D. Philius, Gabrielle Direny, Abdel N. Desir, Luccene Vely, Jean-Francois Streit, Thomas G. Mathieu, Els TI EVALUATION OF INTEGRATED MASS DRUG ADMINISTRATIONS FOR NEGLECTED TROPICAL DISEASES IN HAITI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kennedy, Erin D.; Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Philius, Gabrielle; Vely, Jean-Francois] Minist Hlth, Port Au Prince, Haiti. [Direny, Abdel N.] IMA World Hlth, Port Au Prince, Haiti. [Desir, Luccene; Streit, Thomas G.] Univ Notre Dame, Notre Dame, IN 46556 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 708 BP 203 EP 203 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701124 ER PT J AU Pelletreau, S Lasley, J Bamba, SI Soumare, MD Bamani, S Telly, A Mathieu, E AF Pelletreau, Sonia Lasley, Jennifer Bamba, Sory I. Soumare, Massitan D. Bamani, Sanoussi Telly, Antandou Mathieu, Els TI PERCEPTIONS OF INTEGRATED NEGLECTED TROPICAL DISEASE PROGRAMS AMONG MINISTRY OF HEALTH STAFF IN MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Pelletreau, Sonia; Lasley, Jennifer; Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bamba, Sory I.; Soumare, Massitan D.; Bamani, Sanoussi] Minist Hlth, Bamako, Mali. [Telly, Antandou] Int Trachoma Initiat, Bamako, Mali. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 710 BP 204 EP 204 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701126 ER PT J AU Farnon, EC Adjemian, JA Kansiime, E Rahman, JE Bwire, GS Kahirita, S Kagirita, A Wamala, JF Rollin, PE AF Farnon, Eileen C. Adjemian, Jennifer A. Kansiime, Edgar Rahman, Johanna E. Bwire, Godfrey S. Kahirita, Samuel Kagirita, Atek Wamala, Joseph F. Rollin, Pierre E. TI FILOVIRUS SEROURVEY FOLLOWING AN OUTBREAK OF MARBURG HEMORRHAGIC FEVER --- IBANDA AND KAMWENGE DISTRICTS, UGANDA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Farnon, Eileen C.; Adjemian, Jennifer A.; Rahman, Johanna E.; Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kansiime, Edgar; Bwire, Godfrey S.; Kagirita, Atek; Wamala, Joseph F.] Minist Hlth, Field Epidemiol & Lab, Training Program, Kampala, Uganda. [Kahirita, Samuel] Minist Hlth, Kamwenge Dist Hlth Off, Kamwenge, Uganda. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 726 BP 209 EP 209 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701142 ER PT J AU Hossain, MJ Sazzad, HMS Parveen, S Islam, S Faruque, LI Arman, S Khan, D Husain, MM Jahan, Y Rahman, M Luby, SP Gurley, ES AF Hossain, M. Jahangir Sazzad, Hossain M. S. Parveen, Shahana Islam, Saiful Faruque, Labib Imran Arman, Shaila Khan, Dawlat Husain, M. Mushtuq Jahan, Yasmin Rahman, Mahmudur Luby, Stephen P. Gurley, Emily S. TI HEPATITIS E OUTBREAK IN A LOW INCOME URBAN COMMUNITY IN BANGLADESH SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Hossain, M. Jahangir; Sazzad, Hossain M. S.; Parveen, Shahana; Islam, Saiful; Faruque, Labib Imran; Arman, Shaila; Khan, Dawlat; Husain, M. Mushtuq; Jahan, Yasmin; Rahman, Mahmudur; Gurley, Emily S.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 725 BP 209 EP 209 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701141 ER PT J AU Sebeza, J Kabanda, A Rukelibuga, J Muhimpundu, MA Palekar, R Rusine, J Mukabayire, O Kramer, M AF Sebeza, Jackson Kabanda, Alice Rukelibuga, Joseph Muhimpundu, Marie-Aime Palekar, Rakhee Rusine, John Mukabayire, Odette Kramer, Michael TI INFLUENZA SENTINEL SURVEILLANCE-RWANDA, JULY 2008-MARCH 2009 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Sebeza, Jackson; Muhimpundu, Marie-Aime; Kramer, Michael] Trac Plus MOH, Kigali, Rwanda. [Kabanda, Alice; Rusine, John; Mukabayire, Odette] Natl Reference Lab, Kigali, Rwanda. [Rukelibuga, Joseph] Ctr Dis Control & Prevent, Kigali, Rwanda. [Palekar, Rakhee] Ctr Dis Control & Prevent, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 730 BP 210 EP 211 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701146 ER PT J AU Cohen, AL Ojo, LR O'Loughlin, RE Edmond, KM Shetty, SS Bear, AP Loo, JD Privor-Dumm, L Griffiths, UK Zuber, PL Mayers, GF Hajjeh, R AF Cohen, Adam L. Ojo, Linda R. O'Loughlin, Rosalyn E. Edmond, Karen M. Shetty, Sharmila S. Bear, Allyson P. Loo, Jennifer D. Privor-Dumm, Lois Griffiths, Ulla K. Zuber, Patrick L. Mayers, Gillian F. Hajjeh, Rana TI GAPS IN THE GLOBAL USE OF HAEMOPHILUS INFLUENZAE TYPE B CONJUGATE VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Cohen, Adam L.; Ojo, Linda R.; Loo, Jennifer D.; Hajjeh, Rana] Ctr Dis Control & Prevent, Atlanta, GA USA. [O'Loughlin, Rosalyn E.; Edmond, Karen M.; Griffiths, Ulla K.] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England. [Shetty, Sharmila S.; Bear, Allyson P.; Privor-Dumm, Lois] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Zuber, Patrick L.; Mayers, Gillian F.] WHO, Dept Immunizat Vaccines & Biol, CH-1211 Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 735 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701151 ER PT J AU Brewoo, JN Royals, MA Arguello, JJ Silengo, SJ Powell, TD Partidos, CD Kinney, RM Huang, CY Osorio, JE Stinchcomb, DT AF Brewoo, Joseph N. Royals, Michael A. Arguello, John J. Silengo, Shawn J. Powell, Tim D. Partidos, Charalambos D. Kinney, Richard M. Huang, Claire Y. Osorio, Jorge E. Stinchcomb, Dan T. TI NEEDLE-FREE DELIVERY OF A TETRAVALENT DENGUE VACCINE (DENVAX): SAFETY AND EFFICACY IN NON-HUMAN PRIMATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Brewoo, Joseph N.; Partidos, Charalambos D.] Inviragen Inc, Madison, WI USA. [Royals, Michael A.] PharmaJet Inc, Golden, CO USA. [Arguello, John J.; Silengo, Shawn J.; Powell, Tim D.; Kinney, Richard M.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA. [Huang, Claire Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Osorio, Jorge E.] Univ Wisconsin, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 787 BP 227 EP 227 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701203 ER PT J AU Huang, CY Butrapet, S Erb, SM Moss, K Calvert, A Kinney, RM Roehrig, JT Blair, CD AF Huang, Claire Y. Butrapet, Siritorn Erb, Steven M. Moss, Kelly Calvert, Amanda Kinney, Richard M. Roehrig, John T. Blair, Carol D. TI MOLECULAR DETERMINANTS OF DENGUE VIRUS ENVELOPE PROTEIN IN VIRUS INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Huang, Claire Y.; Moss, Kelly; Calvert, Amanda; Kinney, Richard M.; Roehrig, John T.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Butrapet, Siritorn; Erb, Steven M.; Blair, Carol D.] Colorado State Univ, Ft Collins, CO 80523 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 785 BP 227 EP 227 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701201 ER PT J AU Partidos, CD Brewoo, JN Shilengo, SJ Powell, TD Huang, CYH Kinney, RM Stinchcomb, DT Osorio, JE AF Partidos, Charalambos D. Brewoo, Joseph N. Shilengo, Shawn J. Powell, Tim D. Huang, Claire Y. H. Kinney, Richard M. Stinchcomb, Dan T. Osorio, Jorge E. TI TOWARDS DEVELOPING AN ANIMAL MODEL TO EVALUATE THE PROTECTIVE EFFICACY OF ANTIBODIES RAISED AGAINST CANDIDATE DENGUE VACCINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Partidos, Charalambos D.; Brewoo, Joseph N.] Inviragen Inc, Madison, WI USA. [Shilengo, Shawn J.; Powell, Tim D.; Kinney, Richard M.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA. [Huang, Claire Y. H.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Osorio, Jorge E.] Univ Wisconsin, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 791 BP 228 EP 229 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701207 ER PT J AU Pena-Orellana, M Calderon-Squiabro, JM Rodriguez, R Arguello, F Dayan, G Tomashek, K AF Pena-Orellana, Marisol Calderon-Squiabro, Jose M. Rodriguez, Rosa Argueello, Fermin Dayan, Gustavo Tomashek, Kay TI DENGUE TRENDS BY AGE AND SEX IN PUERTO RICO A HISTORICAL ANALYSIS FROM 1990 TO 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Pena-Orellana, Marisol; Calderon-Squiabro, Jose M.; Rodriguez, Rosa; Argueello, Fermin; Tomashek, Kay] Ctr Dis Control & Prevent, San Juan, PR USA. [Dayan, Gustavo] Sanofi Pasteur, Swiftwater, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 789 BP 228 EP 228 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701205 ER PT J AU Kinney, RM Arguello, JJ Silengo, SJ Bowen, RA Piche, CA Huang, CY Stinchcomb, DT Osorio, JE AF Kinney, Richard M. Arguello, John J. Silengo, Shawn J. Bowen, Richard A. Piche, Claude A. Huang, Claire Y. Stinchcomb, Dan T. Osorio, Jorge E. TI USE OF AG129 MICE TO ASSESS THE SAFETY OF LIVE, ATTENUATED DENGUE VACCINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Kinney, Richard M.; Arguello, John J.; Silengo, Shawn J.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA. [Bowen, Richard A.] Colorado State Univ, Ft Collins, CO 80523 USA. [Piche, Claude A.] Promesa Bio LLC, Ft Collins, CO USA. [Huang, Claire Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Osorio, Jorge E.] Inviragen Inc, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 795 BP 229 EP 230 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701211 ER PT J AU Sever, AE Bose, AS Fischer, M Dhillon, GPS Johnson, BW Robinson, JS Vasanthapuram, VR Ramamurtys, N Desai, A Jafari, HS Sandhu, HS AF Sever, Adrianne E. Bose, Anindya S. Fischer, Marc Dhillon, G. P. S. Johnson, Barbara W. Robinson, Jamie S. Vasanthapuram, V. Ravi Ramamurtys, Nalini Desai, Anita Jafari, Hamid S. Sandhu, Hardeep S. TI ACUTE ENCEPHALITIS SYNDROME SURVEILLANCE FOR JAPANESE ENCEPHALITIS - INDIA, MAY 2007-APRIL 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Sever, Adrianne E.; Fischer, Marc; Johnson, Barbara W.; Robinson, Jamie S.; Sandhu, Hardeep S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bose, Anindya S.; Jafari, Hamid S.] WHO, Natl Polio Surveillance Project India, Delhi, India. [Dhillon, G. P. S.] Natl Vector Borne Dis Control Programme, Delhi, India. [Vasanthapuram, V. Ravi; Desai, Anita] Natl Inst Mental Hlth & Neurosci, Bangalore, Karnataka, India. [Ramamurtys, Nalini] WHO, SE Asia Reg Off, New Delhi, India. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 804 BP 232 EP 232 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701220 ER PT J AU Curtis, KC Fischer, PU Won, KY Lammie, PJ Joseph, HM Melrose, WD Brattig, NW Weill, GJ AF Curtis, Kurt C. Fischer, Peter U. Won, Kimberly Y. Lammie, Patrick J. Joseph, Hayley M. Melrose, Wayne D. Brattig, Norbert W. Weill, Gary J. TI A MULTICENTER EVALUATION OF A NEW ANTIBODY TEST KIT FOR LYMPHATIC FILARIASIS EMPLOYING RECOMBINANT BRUGIA MALAYI ANTIGEN BM-14 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Curtis, Kurt C.; Fischer, Peter U.; Weill, Gary J.] Washington Univ, Sch Med, St Louis, MO USA. [Won, Kimberly Y.; Lammie, Patrick J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Joseph, Hayley M.; Melrose, Wayne D.] James Cook Univ, Townsville, Qld, Australia. [Brattig, Norbert W.] Bernhard Nocht Inst Trop Med, Hamburg, Germany. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 814 BP 235 EP 235 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701230 ER PT J AU Seneviratne, H Lasley, J Richard, S Dorkenoo, AM Sodahlon, Y Mathieu, E AF Seneviratne, Hashini Lasley, Jennifer Richard, Stephanie Dorkenoo, Ameyo M. Sodahlon, Yao Mathieu, Els TI NATURAL PROGRESSION OF LYMPHEDEMA IN TOGO BETWEEN 2004 AND 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Seneviratne, Hashini; Lasley, Jennifer; Richard, Stephanie; Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dorkenoo, Ameyo M.] Minist Hlth, Lome, Togo. [Sodahlon, Yao] Mectizan Donat Program, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 821 BP 237 EP 237 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701237 ER PT J AU Baker, JT Gatton, M Ho, MF Pelecanos, A Bell, D Barnwell, J Hii, J Ogutu, B Oyibo, W Wang, SQ Luchavez, J Membi, C Osario, L Kyaw, MP Clowes, P Kroidl, I Gamboa, D Ariey, F Djalle, D Menard, D Povoa, MM Adhin, M Chen, NH McCarthy, J Cheng, Q AF Baker, Joanne T. Gatton, Michelle Ho, Mei-Fong Pelecanos, Anita Bell, David Barnwell, John Hii, Jeffery Ogutu, Bernhards Oyibo, Wellington Wang, ShanQing Luchavez, Jennifer Membi, Christopher Osario, Lyda Kyaw, Myat Phone Clowes, Petra Kroidl, Inge Gamboa, Dionicia Ariey, Frederic Djalle, Djibrine Menard, Didier Povoa, Marinete Marins Adhin, Malti Chen, Nanhua McCarthy, James Cheng, Qin TI GLOBAL SEQUENCE VARIATION IN THE HISTIDINE-RICH PROTEIN 2 OF PLASMODIUM FALCIPARUM: IMPLICATIONS FOR PERFORMANCE OF RAPID DIAGNOSTIC TESTS FOR MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Baker, Joanne T.; Chen, Nanhua; Cheng, Qin] Australian Army Malaria Inst, Enoggera, 4006, Australia. [Gatton, Michelle; Ho, Mei-Fong; Pelecanos, Anita; McCarthy, James] Queensland Inst Med Res, Herston, Qld, Australia. [Bell, David] WHO, Western Pacific Reg Off, Manila, Philippines. [Barnwell, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ogutu, Bernhards] Kenya Govt Med Res Ctr, Clin Res Ctr, Kisumu, Kenya. [Oyibo, Wellington] Univ Lagos, Coll Med, Lagos, Nigeria. [Wang, ShanQing] Hainan Prov Ctr Dis Control & Prevent, Haikou, Hainan, Peoples R China. [Luchavez, Jennifer] Res Inst Trop Med, Alabang, Philippines. [Membi, Christopher] Bagamoyo Ifakara Hlth Res & Dev Ctr, Ifakara, Tanzania. [Osario, Lyda] Ctr Int Entrenamiento & Invest Med, Cali, Colombia. [Kyaw, Myat Phone] Lower Myanmar Dept Med Res, Yangon, Myanmar. [Clowes, Petra; Kroidl, Inge] Mbeya Med Res Programme, Mbeya, Tanzania. [Ariey, Frederic] Pasteur Inst Cambodia, Phnom Penh, Cambodia. [Djalle, Djibrine] Inst Pasteur, Bangui, Zaire. [Menard, Didier] Inst Pasteur Madagascar, Madagascar, Madagascar. [Povoa, Marinete Marins] Evandro Chagas Inst, Belem, Para, Brazil. [Adhin, Malti] Anton de Kom Univ Suriname, Paramibo, Surinam. RI Menard, Didier/O-3294-2013 OI Menard, Didier/0000-0003-1357-4495 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 860 BP 248 EP 248 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701275 ER PT J AU Masanja, MI McMorrow, M Kahigwa, E Abdulla, SM Kachur, SP AF Masanja, M. Irene McMorrow, Meredith Kahigwa, Elizeus Abdulla, Salim M. Kachur, S. Patrick TI HEALTH WORKERS' USE OF MALARIA RAPID DIAGNOSTIC TESTS (RDTS) TO GUIDE CLINICAL DECISION-MAKING IN RURAL DISPENSARIES, TANZANIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Masanja, M. Irene; Kahigwa, Elizeus; Abdulla, Salim M.] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [McMorrow, Meredith; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S BP 249 EP 249 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701279 ER PT J AU Singh, N Singh, MP Shukla, MM Hussain, M Dash, AP Wylie, BJ Yeboah-Antwi, K Sabin, L Udhayakumar, V Desai, M Hamer, DH AF Singh, Neeru Singh, Mrigendra P. Shukla, Manmohan M. Hussain, Mohassir Dash, Aditya P. Wylie, Blair J. Yeboah-Antwi, Kojo Sabin, Lora Udhayakumar, Venkatachalam Desai, Meghna Hamer, Davidson H. TI BURDEN OF MALARIA IN PREGNANCY IN AREAS OF STABLE AND UNSTABLE MALARIA TRANSMISSION IN CHHATTISGARH, INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Singh, Neeru] Reg Med Res Ctr ICMR, Jabalpur, India. [Singh, Mrigendra P.; Shukla, Manmohan M.; Hussain, Mohassir] Natl Inst Malaria Res Field Stn, Jabalpur, India. [Dash, Aditya P.] Natl Inst Malaria Res, Delhi, India. [Wylie, Blair J.] Massachusetts Gen Hosp, Dept Obstet, Boston, MA 02114 USA. [Yeboah-Antwi, Kojo; Sabin, Lora; Hamer, Davidson H.] Ctr Int Hlth & Dev, Boston, MA USA. [Udhayakumar, Venkatachalam; Desai, Meghna] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 900 BP 259 EP 259 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701315 ER PT J AU Omosun, YO Williamson, J Othoro, C Carrington, M Martin, MP Ayisi, J van Eijk, AM Otieno, J Lal, RB Steketee, R Nahlen, B ter Kuile, F Slutsker, L Shi, YP AF Omosun, Yusuf O. Williamson, John Othoro, Caroline Carrington, Mary Martin, Maureen P. Ayisi, John van Eijk, Anne Maria Otieno, Juliana Lal, Renu B. Steketee, Richard Nahlen, Bernard ter Kuile, Feiko Slutsker, Laurence Shi, Ya Ping TI GENE CONTENT POLYMORPHISMS OF KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTORS (KIRS) IN THE SUSCEPTIBILITY TO AND PROTECTION FROM PLACENTAL MALARIA IN HIV-1 NEGATIVE AND HIV-1 POSITIVE PREGNANT WOMEN IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Omosun, Yusuf O.; Williamson, John; Lal, Renu B.; Steketee, Richard; Nahlen, Bernard; Slutsker, Laurence; Shi, Ya Ping] Ctr Dis Control & Prevent, Atlanta, GA USA. [Othoro, Caroline; Ayisi, John; van Eijk, Anne Maria] Ctr Vector Biol & Control Res, Kenyan Med Res Inst, Kisumu, Kenya. [Carrington, Mary; Martin, Maureen P.] SAIC Frederick, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA. [Otieno, Juliana] Minist Hlth, New Nyanza Prov Gen Hosp, Kisumu, Kenya. [ter Kuile, Feiko] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 917 BP 264 EP 264 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701331 ER PT J AU Soberon, VR Salas, CJ McCollum, AM Santolalla, M Durand, S Udhayakumar, V Lucas, CM Bacon, DJ AF Soberon, Valeria R. Salas, Carola J. McCollum, Andrea M. Santolalla, Meddly Durand, Salomon Udhayakumar, Venkatachalam Lucas, Carmen M. Bacon, David J. TI USE OF MICROSATELLITE MARKERS TO DISTINGUISH RECRUDESCENCE FROM REINFECTION IN PLASMODIUM VIVAX INFECTIONS FROM THE PERUVIAN AMAZON BASIN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Soberon, Valeria R.; Salas, Carola J.; Santolalla, Meddly; Durand, Salomon; Lucas, Carmen M.; Bacon, David J.] US Naval Med Res Ctr Detachment, Lima, Peru. [McCollum, Andrea M.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 925 BP 266 EP 267 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701339 ER PT J AU Soodoo, NK Barnett, ED Stevenson, A Pelton, SI Yanni, E Marano, N Chen, LH Wilson, ME Ooi, WW Kogelman, L Karchmer, AW Hamer, DH AF Soodoo, Natasha K. Barnett, Elizabeth D. Stevenson, Abbie Pelton, Stephen I. Yanni, Emad Marano, Nina Chen, Lin H. Wilson, Mary E. Ooi, Winnie W. Kogelman, Laura Karchmer, Adolf W. Hamer, Davidson H. TI CHIKUNGUNYA VIRUS ANTIBODY IN TRAVELERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Soodoo, Natasha K.; Barnett, Elizabeth D.; Stevenson, Abbie] Boston Med Ctr, Boston, MA USA. [Yanni, Emad; Marano, Nina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chen, Lin H.] Mt Auburn Hosp, Cambridge, MA USA. [Wilson, Mary E.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Ooi, Winnie W.] Lahey Clin Fdn, Burlington, MA USA. [Kogelman, Laura] Tufts Med Ctr, Boston, MA USA. [Karchmer, Adolf W.] Beth Israel Deaconess, Boston, MA USA. [Hamer, Davidson H.] Boston Univ, Sch Publ Hlth, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 997 BP 287 EP 287 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701411 ER PT J AU Cantey, PT Rao, G Rout, J Jolly, A Williamson, J Fox, L AF Cantey, Paul T. Rao, Grace Rout, Jonathan Jolly, Anna Williamson, John Fox, LeAnne TI INCREASED ADHERENCE TO MASS DRUG ADMINISTRATION FOR LYMPHATIC FILARIASIS - ORISSA STATE, INDIA, 2009 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Cantey, Paul T.; Jolly, Anna; Williamson, John; Fox, LeAnne] Ctr Dis Control & Prevent, Div Parasit Dis, NCZVED, Atlanta, GA USA. [Rao, Grace; Rout, Jonathan] Churchs Auxiliary Social Act, Bhubaneswar, Orissa, India. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1020 BP 293 EP 294 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701434 ER PT J AU John, CC Riedesel, MA Magak, NG Menge, DM Lindblade, KA Vulule, JM Hodges, JA Akhwale, W AF John, Chandy C. Riedesel, Melissa A. Magak, Ng'wena G. Menge, David M. Lindblade, Kim A. Vulule, John M. Hodges, James A. Akhwale, Willis TI POSSIBLE INTERRUPTION OF MALARIA TRANSMISSION IN TWO HIGHLAND AREAS OF KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [John, Chandy C.; Riedesel, Melissa A.; Menge, David M.; Hodges, James A.] Univ Minnesota, Minneapolis, MN USA. [Magak, Ng'wena G.] Moi Univ, Eldoret, Kenya. [Lindblade, Kim A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Vulule, John M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Akhwale, Willis] Minist Hlth, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1025 BP 295 EP 295 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701439 ER PT J AU Hamel, MJ Otieno, P Bayoh, N Kariuki, S Laserson, K Akhwale, W Williamson, J Slutsker, L Gimnig, J AF Hamel, Mary J. Otieno, Peter Bayoh, Nabie Kariuki, Simon Laserson, Kayla Akhwale, Willis Williamson, John Slutsker, Laurence Gimnig, John TI DOES INDOOR RESIDUAL SPRAYING PROVIDE ADDED PROTECTION TO INSECTICIDE TREATED NETS IN PREVENTING MALARIA - PRELIMINARY RESULTS OF AN INCIDENCE COHORT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Hamel, Mary J.; Otieno, Peter; Bayoh, Nabie; Kariuki, Simon; Laserson, Kayla] Ctr Dis Control & Prevent, Kenya Med Res Inst, Res Stn, Kisumu, Kenya. [Akhwale, Willis] Kenya Minist Hlth, Nairobi, Kenya. [Williamson, John; Slutsker, Laurence; Gimnig, John] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1027 BP 296 EP 296 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701441 ER PT J AU Koita, OA Ylostalo, JH Colborn, JM Cisse, OH Krogstad, DJ AF Koita, Ousmane A. Ylostalo, Joni H. Colborn, James M. Cisse, Ousmane H. Krogstad, Donald J. TI DOWN-REGULATION OF ANTI-INFLAMMATORY AND ANTI-APOPTOTIC GENE EXPRESSION DURING UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Bamako, Mali. [Colborn, James M.] Ctr Dis Control & Prevent, San Juan, PR USA. [Ylostalo, Joni H.] Univ Texas, Temple, TX USA. [Krogstad, Donald J.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1043 BP 300 EP 301 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701457 ER PT J AU Thwing, JI Njau, JD Goodman, CA Kachur, SP Kahigwa, E Abdullah, S AF Thwing, Julie I. Njau, Joseph D. Goodman, Catherine A. Kachur, S. Patrick Kahigwa, Elizeus Abdullah, Salim TI RAPID UPTAKE OF ARTEMISININ-BASED COMBINATION THERAPY IN RUFIJI DISTRICT, TANZANIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Thwing, Julie I.; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. [Njau, Joseph D.; Kahigwa, Elizeus; Abdullah, Salim] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [Goodman, Catherine A.] KEMRI Wellcome Trust, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1054 BP 304 EP 304 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701468 ER PT J AU Bhattarai, A O'Reilly, CE Abayneh, SA Fantu, R Mekonnen, A Ahmed, J Feleke, B Quick, R AF Bhattarai, Achuyt O'Reilly, Ciara E. Abayneh, Sisay Alemayehu Fantu, Ribka Mekonnen, Alemayehu Ahmed, Jelaludin Feleke, Beniam Quick, Rob TI A COMPARISON OF WATER TREATMENT PRACTICES AMONG PEOPLE LIVING WITH HIV/AIDS AND COMMUNITY MEMBERS IN ETHIOPIA, DECEMBER, 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Bhattarai, Achuyt; O'Reilly, Ciara E.; Quick, Rob] Ctr Dis Control & Prevent, Atlanta, GA USA. [Abayneh, Sisay Alemayehu; Fantu, Ribka; Mekonnen, Alemayehu; Ahmed, Jelaludin; Feleke, Beniam] Ctr Dis Control & Prevent, Addis Ababa, Ethiopia. RI Bhattarai, Achuyt/B-8760-2008 OI Bhattarai, Achuyt/0000-0002-0514-4850 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1062 BP 306 EP 306 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701476 ER PT J AU Komar, N Hunsperger, E Bessoff, K Diaz, A Amador, M Young, G Seda, R Perez, T Barrera, R AF Komar, Nicholas Hunsperger, Elizabeth Bessoff, Kovi Diaz, Annette Amador, Manuel Young, Ginger Seda, Rafael Perez, Taonex Barrera, Roberto TI AVIAN HOSTS OF WEST NILE VIRUS IN PUERTO RICO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Komar, Nicholas; Young, Ginger] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Hunsperger, Elizabeth; Bessoff, Kovi; Diaz, Annette; Amador, Manuel; Barrera, Roberto] Ctr Dis Control & Prevent, San Juan, PR USA. [Seda, Rafael; Perez, Taonex] Puerto Rico Dept Hlth, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1096 BP 317 EP 317 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701510 ER PT J AU Maharaj, PD Anishchenko, M Langevin, SA Brault, AC AF Maharaj, Payal D. Anishchenko, Michael Langevin, Stanley A. Brault, Aaron C. TI WEST NILE AND ST. LOUIS ENCEPHALITIS VIRUSES: IDENTIFICATION OF GENETIC DETERMINANTS OF ALTERED AVIAN AND VECTOR INFECTION PHENOTYPES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Maharaj, Payal D.; Brault, Aaron C.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Anishchenko, Michael; Langevin, Stanley A.] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1120 BP 323 EP 324 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701534 ER PT J AU Thibodeaux, BA Roehrig, JT Schlesinger, JJ Blair, CD AF Thibodeaux, Brett A. Roehrig, John T. Schlesinger, Jacob J. Blair, Carol D. TI HUMANIZED ANTI-YELLOW FEVER VIRUS MURINE MONOCLONAL ANTIBODY PROTECTS AG129 MICE FROM PERIPHERAL VIRUS CHALLENGE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Thibodeaux, Brett A.; Blair, Carol D.] Colorado State Univ, Ft Collins, CO 80523 USA. [Roehrig, John T.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Schlesinger, Jacob J.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1124 BP 324 EP 325 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701538 ER PT J AU Anthony, G Deming, M Dorkenoo, AM Morgah, K Verani, J Seim, A Dogbe, K Sodahlon, Y Mathieu, E AF Anthony, Gabriel Deming, Michael Dorkenoo, Ameyo M. Morgah, Kodjo Verani, Jennifer Seim, Anders Dogbe, Komi Sodahlon, Yao Mathieu, Els TI THE INTEGRATION OF NEGLECTED DISEASES: THREE YEARS OF EXPERIENCE IN TOGO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Anthony, Gabriel] Hlth & Dev Int, Lome, Togo. [Deming, Michael; Verani, Jennifer; Mathieu, Els] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dorkenoo, Ameyo M.; Morgah, Kodjo; Dogbe, Komi] Minist Hlth, Lome, Togo. [Sodahlon, Yao] Mectizan Donat Program, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1134 BP 327 EP 328 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701548 ER PT J AU Neil, K Sodha, S Luswago, L O-tipo, S Mikoleit, M Simington, S Majalija, S Kagirita, A Balinandi, S Mukobi, P Kweyamba, V Batten, B Adem, P Talkington, D Zaki, S Mintz, E AF Neil, Karen Sodha, Samir Luswago, Luswa O-tipo, Shikanga Mikoleit, Matthew Simington, Sherricka Majalija, Sam Kagirita, Atek Balinandi, Stephen Mukobi, Peter Kweyamba, Vianney Batten, Brigid Adem, Patricia Talkington, Deborah Zaki, Sharif Mintz, Eric TI OUTBREAK OF TYPHOID FEVER WITH HIGH RATE OF INTESTINAL PERFORATION, KASESE DISTRICT, UGANDA-2008-2009 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Neil, Karen; Sodha, Samir; Mikoleit, Matthew; Simington, Sherricka; Batten, Brigid; Adem, Patricia; Talkington, Deborah; Zaki, Sharif; Mintz, Eric] Ctr Dis Control & Prevent, Atlanta, GA USA. [Luswago, Luswa] Minist Hlth, Kampala, Uganda. [O-tipo, Shikanga; Balinandi, Stephen] Field Epidemiol & Lab Training Program, Nairobi, Kenya. [Majalija, Sam] Makerere Univ, Kampala, Uganda. [Kagirita, Atek] Cent Publ Hlth Lab, Kampala, Uganda. [Kweyamba, Vianney] Bwera Hosp, Bwera, Uganda. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1142 BP 330 EP 330 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701556 ER PT J AU O-tipo, S Neil, K Sodha, S Luswago, L Mukobi, P Balinandi, S Majalija, S Kagirita, A Mintz, E AF O-tipo, Shikanga Neil, Karen Sodha, Samir Luswago, Luswa Mukobi, Peter Balinandi, Stephen Majalija, Sam Kagirita, Atek Mintz, Eric TI TYPHOID FEVER OUTBREAK IN KASESE DISTRICT, UGANDA: 103 CASES WITH INTESTINAL PERFORATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [O-tipo, Shikanga; Balinandi, Stephen] Field Epidemiol & Lab Training Program, Nairobi, Kenya. [Neil, Karen; Sodha, Samir; Mintz, Eric] Ctr Dis Control & Prevent, Atlanta, GA USA. [Luswago, Luswa] Minist Hlth, Kampala, Uganda. [Majalija, Sam] Makerere Univ, Kampala, Uganda. [Kagirita, Atek] Cent Publ Hlth Lab, Kampala, Uganda. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1143 BP 330 EP 331 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701557 ER PT J AU Omore, R O'Reilly, CE Ochieng, B Blanton, E Crump, J Farag, TH Berkeley, L Panchalingam, S Nataro, JP Kotloff, K Levine, M Moke, F Ondeng, A Jaron, P Abir, A Okonji, C Parsons, M Bopp, C Oundo, J Vulule, J Adazu, K Feikin, D Laserson, K Mintz, E Breiman, RF AF Omore, Richard O'Reilly, Ciara E. Ochieng, Benjamin Blanton, Elizabeth Crump, John Farag, Tamer H. Berkeley, Lynette Panchalingam, Sandra Nataro, James P. Kotloff, Karen Levine, Myron Moke, Fenny Ondeng, Alex Jaron, Peter Abir, Alfred Okonji, Caleb Parsons, Michele Bopp, Cheryl Oundo, Joseph Vulule, John Adazu, Kubaje Feikin, Daniel Laserson, Kayla Mintz, Eric Breiman, Robert F. TI MORTALITY AMONG CHILDREN WITH MODERATE-TO-SEVERE DIARRHEA IN RURAL WESTERN KENYA, 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 18-22, 2009 CL Washington, DC SP Amer Soc Trop Med & Hyg C1 [Omore, Richard; Ochieng, Benjamin; Moke, Fenny; Ondeng, Alex; Jaron, Peter; Abir, Alfred; Okonji, Caleb; Oundo, Joseph; Adazu, Kubaje; Feikin, Daniel; Laserson, Kayla] Ctr Dis Control & Prevent, Kenya Med Res Inst, Kisumu, Kenya. [O'Reilly, Ciara E.; Blanton, Elizabeth; Crump, John; Parsons, Michele; Bopp, Cheryl; Mintz, Eric] Ctr Dis Control & Prevent, Atlanta, GA USA. [Farag, Tamer H.; Berkeley, Lynette; Panchalingam, Sandra; Nataro, James P.; Kotloff, Karen; Levine, Myron] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Vulule, John] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Breiman, Robert F.] Ctr Dis Control & Prevent, Kenya Med Res Inst, Nairobi, Kenya. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 SU S MA 1141 BP 330 EP 330 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WK UT WOS:000271956701555 ER PT J AU King, JD Eigege, A Richards, F Jip, N Umaru, J Deming, M Miri, E McFarland, D Emerson, PM AF King, Jonathan D. Eigege, Abel Richards, Frank, Jr. Jip, Nimzing Umaru, John Deming, Michael Miri, Emmanuel McFarland, Deborah Emerson, Paul M. TI Integrating NTD Mapping Protocols: Can Surveys for Trachoma and Urinary Schistosomiasis Be Done Simultaneously? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PEMBA ISLAND; PREVALENCE; NIGERIA; STATE; HEMATURIA; MORBIDITY; PROGRAM AB We determined whether the school-based "disease mapping" methodology used to assess urinary schistosomiasis (SCH) is useful for determining trachoma interventions and whether the district-based approach recommended for trachoma is useful for SCH control programs. We conducted two separate integrated Surveys in eight districts of central Nigeria: school based and district based. A total of 17,189 children were examined for trachoma and 16,238 children were examined for hematuria from 363 schools and 2,149 households. School surveys identified 67 communities warranting praziquantel drug treatment of SCH and 142 trachoma-endemic communities warranting trachoma control activities. In district-level estimates, we identified 24 communities for praziquantel treatment and 0 for trachoma intervention. Integrating trachoma into SCH school-based surveys, and SCH into trachoma surveys, was quick and easy, but in this setting, school-based surveys were more useful for identifying communities where intervention is warranted. C1 [King, Jonathan D.; Richards, Frank, Jr.; Emerson, Paul M.] Carter Ctr, Atlanta, GA 30306 USA. [Eigege, Abel; Jip, Nimzing; Umaru, John; Miri, Emmanuel] Carter Ctr, Jos, Plateau, Nigeria. [Deming, Michael] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Parasit Dis Branch, Atlanta, GA 30341 USA. [McFarland, Deborah] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP King, JD (reprint author), Carter Ctr, 1149 Ponce de Leon Ave, Atlanta, GA 30306 USA. EM jonathan.king@emory.edu; eigegea@yahoo.com; frich01@emory.edu; flmnimzing@yahoo.com; umaruja@yahoo.com; msd1@cdc.gov; emmamiri@yahoo.com; dmcfarl@sph.emory.edu; pemerso@emory.edu FU Bill and Melinda Gates Foundation FX The survey described in this paper was funded by a generous grant to The Carter Center by the Bill and Melinda Gates Foundation Grant on Integration. The funders had no role in study design; collection, analysis, and interpretation of data; writing of the paper; or decision to submit it for publication. NR 18 TC 10 Z9 10 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 793 EP 798 DI 10.4269/ajtmh.2009.09-0236 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500013 PM 19861613 ER PT J AU Bai, Y Kosoy, MY Lerdthusnee, K Peruski, LF Richardson, JH AF Bai, Ying Kosoy, Michael Y. Lerdthusnee, Kriangkrai Peruski, Leonard F. Richardson, Jason H. TI Prevalence and Genetic Heterogeneity of Bartonella Strains Cultured from Rodents from 17 Provinces in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SP-NOV; SOUTHERN CHINA; DIVERSITY; GRAHAMII; PATIENT; TAYLORII; MAMMALS; RATTUS; FLEAS; RATS AB To study the distribution and diversity of Bartonella in rodents from Thailand, 330 rodents belonging to 13 species were tested. The majority (80.6%) of rodents examined belonged to the genus Rattus. Bartonellae were Cultured from 41.5% of the rodents with a wide range of prevalence by host species and regions. Sequencing of gltA revealed diverse Bartonella strains. Bartonellae from Rattus spp. belonged to 23 variants and clustered with Bartonella coopersplainensis, Bartonella elizabethae, Bartonella phoceensis, Bartonella rattimassiliensis, Bartonella tribocorum, and all unknown geno-group. Bartonellae from Bandicota spp. belonged to six variants and clustered with B. coopersplainensis, B. rattimassilliensis, and B. tribocorum. Three variants from Mus spp. clustered with B. coopersplainensis or B. rattimassilliensis. The only isolate from a Berylmys berdmorei fell into the B. tribocorum group. The observations highlight the need to study these agents for their role in human febrile illnesses of unknown etiology in Thailand and elsewhere in Asia. C1 [Bai, Ying; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. [Lerdthusnee, Kriangkrai; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Peruski, Leonard F.] Thai MOPH US CDC Collaborat, Int Emerging Infect Program, Bangkok 11000, Thailand. RP Bai, Y (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. EM bby5@cdc.gov RI Richardson, Jason/A-9441-2011 NR 23 TC 30 Z9 32 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 811 EP 816 DI 10.4269/ajtmh.2009.09-0294 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500016 PM 19861616 ER PT J AU Luby, SP Halder, AK Tronchet, C Akhter, S Bhuiya, A Johnston, RB AF Luby, Stephen P. Halder, Amal K. Tronchet, Carole Akhter, Shamima Bhuiya, Abbas Johnston, Richard B. TI Household Characteristics Associated with Handwashing with Soap in Rural Bangladesh SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; CHILDHOOD DIARRHEA; URBAN BANGLADESH; BURKINA-FASO; HYGIENE; WATER; INTERVENTION; INDICATORS; COST; QUESTIONNAIRES AB Handwashing with soap prevents diarrhea and respiratory disease, but it is rarely practiced in high-need settings. Among 100 randomly selected villages in rural Bangladesh, field workers enrolled 10 households per village and observed and recorded household activities for 5 hours. Field workers observed 761 handwashing opportunities among household members in 527 households who had just defecated or who cleaned a child's anus who had defecated. In the final multivariate analysis, having water available at the place to wash hands after toileting (odds ratio = 2.2, 95% confidence interval 1.3, 4.0) and having soap available at the place to wash hands after toileting (odds ratio = 2.1, 95% confidence interval 1.3, 3.4) were associated with washing both hands with soap after fecal contact. Interventions that improve the presence of water and soap at the designated place to wash hands would be expected to improve handwashing behavior and health. C1 [Luby, Stephen P.] ICDDR B, Dhaka 1000, Bangladesh. Ctr Dis Control & Prevent, Atlanta, GA USA. UNICEF Bangladesh, Water & Environm Sanitat Sect, Dhaka 1000, Bangladesh. RP Luby, SP (reprint author), ICDDR B, GPO Box 128, Dhaka 1000, Bangladesh. EM sluby@icddrb.org; Amal_Halder@wvi.org; ctronchet@unicef.org; shamima@uab.edu; abbas@icddrb.org; Richard.Johnston@eawag.ch FU United Kingdom Department for International Development (DFID) through UNICEF Bangladesh FX Financial support: This program evaluation was funded by the United Kingdom Department for International Development (DFID) through UNICEF Bangladesh. ICDDR,Backnowledges with gratitude the commitment of DFID and UNICEF to the Centre's research efforts. NR 29 TC 35 Z9 35 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2009 VL 81 IS 5 BP 882 EP 887 DI 10.4269/ajtmh.2009.09-0031 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 521WI UT WOS:000271956500026 PM 19861626 ER PT J AU Hazen, TH Martinez, RJ Chen, YF Lafon, PC Garrett, NM Parsons, MB Bopp, CA Sullards, MC Sobecky, PA AF Hazen, Tracy H. Martinez, Robert J. Chen, Yanfeng Lafon, Patricia C. Garrett, Nancy M. Parsons, Michele B. Bopp, Cheryl A. Sullards, M. Cameron Sobecky, Patricia A. TI Rapid Identification of Vibrio parahaemolyticus by Whole-Cell Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID GEL-ELECTROPHORESIS PROTOCOL; COMPLETE GENOME SEQUENCE; MULTIPLEX PCR; CLINICAL SOURCES; III SECRETION; SHELLFISH; BACTERIA; STRAINS; DIFFERENTIATION; CLASSIFICATION AB Vibrio parahaemolyticus is a pathogenic marine bacterium that is the main causative agent of bacterial seafood-borne gastroenteritis in the United States. An increase in the frequency of V. parahaemolyticus-related infections during the last decade has been attributed to the emergence of an O3:K6 pandemic clone in 1995. The diversity of the O3:K6 pandemic clone and its serovariants has been examined using multiple molecular techniques including multilocus sequence analysis, pulsed-field gel electrophoresis, and group-specific PCR analysis. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has become a powerful tool for rapidly distinguishing between related bacterial species. In the current study, we demonstrate the development of a whole-cell MALDI-TOF MS method for the distinction of V. parahaemolyticus from other Vibrio spp. We identified 30 peaks that were present only in the spectra of the V. parahaemolyticus strains examined in this study that may be developed as MALDI-TOF MS biomarkers for identification of V. parahaemolyticus. We detected variation in the MALDI-TOF spectra of V. parahaemolyticus strains isolated from different geographical locations and at different times. The MALDI-TOF MS spectra of the V. parahaemolyticus strains examined were distinct from those of the other Vibrio species examined including the closely related V. alginolyticus, V. harveyi, and V. campbellii. The results of this study demonstrate the first use of whole-cell MALDI-TOF MS analysis for the rapid identification of V. parahaemolyticus. C1 [Hazen, Tracy H.; Martinez, Robert J.; Sullards, M. Cameron; Sobecky, Patricia A.] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA. [Chen, Yanfeng; Sullards, M. Cameron] Georgia Inst Technol, Sch Chem & Biochem, Parker H Petit Inst Biosci & Bioengn, Atlanta, GA 30332 USA. [Lafon, Patricia C.; Garrett, Nancy M.; Parsons, Michele B.; Bopp, Cheryl A.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. RP Sobecky, PA (reprint author), 300 Hackberry Lane, Tuscaloosa, AL 35401 USA. EM psobecky@bama.ua.edu OI Martinez, Robert/0000-0003-0836-4776 FU GT/CDC [1241326] FX This project was supported in part by GT/CDC seed grant no. 1241326 to P. A. Sobecky and C. A. Bopp. Instrumentation for sequencing was supported by NSF grant DBI-0304606. NR 44 TC 30 Z9 35 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD NOV 1 PY 2009 VL 75 IS 21 BP 6745 EP 6756 DI 10.1128/AEM.01171-09 PG 12 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 511KA UT WOS:000271161700015 PM 19749061 ER PT J AU Crider, KS Cleves, MA Reefhuis, J Berry, RJ Hobbs, CA Hu, DJ AF Crider, Krista S. Cleves, Mario A. Reefhuis, Jennita Berry, Robert J. Hobbs, Charlotte A. Hu, Dale J. TI Antibacterial Medication Use During Pregnancy and Risk of Birth Defects National Birth Defects Prevention Study SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID FOLIC-ACID ANTAGONISTS; ANTIBIOTICS; LACTATION AB Objective: To estimate the association between antibacterial medications and selected birth defects. Design, Setting, and Participants: Population-based, multisite, case-control study of women who had pregnancies affected by 1 of more than 30 eligible major birth defects identified via birth defect surveillance programs in 10 states (n = 13 155) and control women randomly selected from the same geographical regions (n = 4941). Main Exposure: Reported maternal use of antibacterials (1 month before pregnancy through the end of the first trimester). Main Outcome Measure: Odds ratios (ORs) measuring the association between antibacterial use and selected birth defects adjusted for potential confounders. Results: The reported use of antibacterials increased during pregnancy, peaking during the third month. Sulfonamides were associated with anencephaly (adjusted OR [AOR] = 3.4; 95% confidence interval [CI], 1.3-8.8), hypoplastic left heart syndrome (AOR = 3.2; 95% CI, 1.3-7.6), coarctation of the aorta (AOR = 2.7; 95% CI, 1.3-5.6), choanal atresia (AOR = 8.0; 95% CI, 2.7-23.5), transverse limb deficiency (AOR = 2.5; 95% CI, 1.0-5.9), and diaphragmatic hernia (AOR = 2.4; 95% CI, 1.1-5.4). Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9). Other antibacterial agents that showed associations included erythromycins (2 defects), penicillins (1 defect), cephalosporins (1 defect), and quinolones (1 defect). Conclusions: Reassuringly, penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. Sulfonamides and nitrofurantoins were associated with several birth defects, indicating a need for additional scrutiny. C1 [Crider, Krista S.; Reefhuis, Jennita; Berry, Robert J.; Hu, Dale J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Cleves, Mario A.; Hobbs, Charlotte A.] Univ Arkansas Med Sci, Dept Pediat, Coll Med, Little Rock, AR 72205 USA. RP Crider, KS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM kcrider@cdc.gov RI Publications, NBDPS/B-7692-2013; OI Berry, Robert/0000-0002-7162-5046 FU Centers for Disease Control and Prevention [PA 01081] FX The National Birth Defects Prevention Study is funded by cooperative agreement PA 01081 from the Centers for Disease Control and Prevention. NR 14 TC 69 Z9 75 U1 0 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD NOV PY 2009 VL 163 IS 11 BP 978 EP 985 PG 8 WC Pediatrics SC Pediatrics GA 514WU UT WOS:000271427700002 PM 19884587 ER PT J AU Banyai, K Esona, MD Kerin, TK Hull, JJ Mijatovic, S Vasconez, N Torres, C de Filippis, AMB Gentsch, JR AF Banyai, Krisztian Esona, Mathew D. Kerin, Tara K. Hull, Jennifer J. Mijatovic, Slavica Vasconez, Nancy Torres, Carlos de Filippis, Ana M. B. Gentsch, Jon R. TI Molecular characterization of a rare, human-porcine reassortant rotavirus strain, G11P[6], from Ecuador SO ARCHIVES OF VIROLOGY LA English DT Article ID GROUP-A ROTAVIRUS; POLYMERASE CHAIN-REACTION; INTERSPECIES TRANSMISSION; ACUTE GASTROENTERITIS; VACCINE INTRODUCTION; PROVIDES EVIDENCE; SEROTYPE G6; NSP4 GENES; CHILDREN; DIARRHEA AB The Pan-American Health Organization established a rotavirus pre-vaccination disease burden and strain surveillance network in Latin America and the Caribbean in 2004. During strain surveillance in Ecuador in 2005-2006, a rare rotavirus genotype, G11P[6], was detected among common strains. Sequencing and phylogenetic analysis of this strain identified a novel lineage of the G11 VP7 gene, most closely related to A253 (91.8% nt identity), a porcine rotavirus strain identified in Venezuela. Most genes of this strain clustered with porcine, human-porcine or bovine-porcine reassortant strains; only VP6 and perhaps NSP2 genes were more closely related to cognate genes of human rotaviruses. Thus, this strain was likely generated by gene reassortment between porcine and human parental strains. Our study provides further evidence that animal rotaviruses play an important role in genetic and antigenic diversity of rotaviruses pathogenic for humans. C1 [Esona, Mathew D.; Kerin, Tara K.; Hull, Jennifer J.; Mijatovic, Slavica; Gentsch, Jon R.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. [Banyai, Krisztian] Assoc Publ Hlth Labs, Silver Spring, MD USA. [Banyai, Krisztian] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary. [Vasconez, Nancy] Coordinadora Nacl PAI, Quito, Ecuador. [Torres, Carlos] MSP, Quito, Ecuador. [de Filippis, Ana M. B.] Pan Amer Hlth Org, Immunizat Unit, Washington, DC USA. RP Gentsch, JR (reprint author), Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. EM bkrota@hotmail.com; jrg4@cdc.gov OI Banyai, Krisztian/0000-0002-6270-1772 NR 46 TC 36 Z9 38 U1 1 U2 6 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PD NOV PY 2009 VL 154 IS 11 BP 1823 EP 1829 DI 10.1007/s00705-009-0499-1 PG 7 WC Virology SC Virology GA 511VC UT WOS:000271198100012 PM 19763776 ER PT J AU Dolan, SM Callaghan, WM Rasmussen, SA AF Dolan, Siobhan M. Callaghan, William M. Rasmussen, Sonja A. TI Birth Defects and Preterm Birth: Overlapping Outcomes with a Shared Strategy for Research and Prevention SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Editorial Material ID NEURAL-TUBE DEFECTS; ASSISTED REPRODUCTIVE TECHNOLOGY; UNITED-STATES; INFANT-MORTALITY; PRECONCEPTION CARE; MATERNAL SMOKING; RISK; DELIVERY; POLYMORPHISMS; METAANALYSIS C1 [Dolan, Siobhan M.] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10461 USA. [Dolan, Siobhan M.] March Dimes, White Plains, NY USA. [Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Dolan, SM (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Belfer 501,1300 Morris Pk Ave, Bronx, NY 10461 USA. EM siobhanmdolan@yahoo.com NR 69 TC 4 Z9 4 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD NOV PY 2009 VL 85 IS 11 BP 874 EP 878 DI 10.1002/bdra.20634 PG 5 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 525GB UT WOS:000272201500002 PM 19824057 ER PT J AU Schmidt, RJ Romitti, PA Burns, TL Browne, ML Druschel, CM Olney, RS AF Schmidt, Rebecca J. Romitti, Paul A. Burns, Trudy L. Browne, Marilyn L. Druschel, Charlotte M. Olney, Richard S. CA Natl Birth Defects Prevention Stud TI Maternal Caffeine Consumption and Risk of Neural Tube Defects SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE anencephaly; caffeine; coffee; encephalocele; neural tube defect; spinal dysraphism; pregnancy; tea ID RANDOMIZED CONTROLLED-TRIAL; SOFT DRINK CONSUMPTION; GREEN TEA CONSUMPTION; BIRTH-DEFECTS; COFFEE CONSUMPTION; SPONTANEOUS-ABORTION; VITAMIN SUPPLEMENTATION; PLASMA HOMOCYSTEINE; HEALTHY-VOLUNTEERS; UNITED-STATES AB Animal studies demonstrate teratogenic effects of caffeine, whereas human studies are inconclusive. METHODS: Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS). Total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy was estimated for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002. Periconceptional use of caffeine-containing medications was evaluated separately. Adjusted odds ratios (OR) and 95% confidence intervals (CI) associated with consumption of total caffeine and each caffeine source were estimated from logistic regression models. RESULTS: Positive associations were observed between spina bifida and total caffeine consumption (OR 1.4; 95% CI: 1.1-1.9) and each caffeine source except caffeinated tea, which showed a negative association with spina bifida (OR 0.7; 95% CI: 0.6-0.9). Associations with modestly increased risk of NTDs and encephalocele were also observed. The association between caffeine consumption and anencephaly differed by maternal race/ethnicity. No dose effects were found. CONCLUSIONS: Additional studies should confirm whether women who consume caffeine are at increased risk for pregnancies complicated by NTDs. Birth Defects Research (Part A) 85:879-889, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Schmidt, Rebecca J.] Univ Calif Davis, Dept Psychiat, MIND Inst, Davis Med Ctr, Davis, CA 95616 USA. [Romitti, Paul A.; Burns, Trudy L.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA. [Browne, Marilyn L.; Druschel, Charlotte M.] New York State Dept Hlth, Congenital Malformat Registry, Troy, NY USA. [Olney, Richard S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Schmidt, RJ (reprint author), Univ Calif Davis, Dept Psychiat, MIND Inst, Davis Med Ctr, Davis, CA 95616 USA. EM rjschmidt@ucdavis.edu RI Publications, NBDPS/B-7692-2013 FU Centers for Disease Control and Prevention [IJ50/CCU 713238] FX This work was supported by a grant from the Centers for Disease Control and Prevention (IJ50/CCU 713238). The authors acknowledge the investigators and staff of the National Birth Defects Prevention Study (NBDPS) for their valuable contributions. NR 81 TC 30 Z9 30 U1 6 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD NOV PY 2009 VL 85 IS 11 BP 879 EP 889 DI 10.1002/bdra.20624 PG 11 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 525GB UT WOS:000272201500003 PM 19711421 ER PT J AU Parker, SE Mai, CT Strickland, MJ Olney, RS Rickard, R Marengo, L Wang, Y Hashmi, SS Meyer, RE AF Parker, Samantha E. Mai, Cara T. Strickland, Matthew J. Olney, Richard S. Rickard, Russel Marengo, Lisa Wang, Ying Hashmi, S. Shahrukh Meyer, Robert E. CA Natl Birth Defects Prevention Netw TI Multistate Study of the Epidemiology of Clubfoot SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE clubfoot; talipes equinovarus; birth defects surveillance ID CONGENITAL TALIPES EQUINOVARUS; MATERNAL SMOKING; BIRTH-DEFECTS; POPULATION; FOOT; INFANTS; HAWAII; SWEDEN; RISK AB Although clubfoot is a common birth defect, with a prevalence of approximately I per 1000 livebirths, the etiology of clubfoot remains largely unknown. Studies of the prevalence and risk factors for clubfoot in the United States have previously been limited to specific states. The purpose of this study was to pool data from several birth defects surveillance programs to better estimate the prevalence of clubfoot and investigate its risk factors. METHODS: The 10 population-based birth defects surveillance programs that participated in this study ascertained 6139 cases of clubfoot from 2001 through 2005. A random sample of 10 controls per case, matched on year and state of birth, was selected from birth certificates. Data on infant and maternal risk factors were collected from birth certificates. Prevalence was calculated by pooling the state-specific data. Conditional logistic regression was used to investigate the association between risk factors and clubfoot. RESULTS: The overall prevalence of clubfoot was 1.29 per 1.000 livebirths; 1.38 among non-Hispanic whites, 1.30 among Hispanics, and 1.14 among non-Hispanic blacks or African Americans. Maternal age, parity, education, and marital status were significantly associated with clubfoot. Maternal smoking and diabetes also showed significant associations. Several of these observed associations were consistent between surveillance programs. CONCLUSIONS: We estimated the prevalence of clubfoot using data from several birth defects programs, representing one-quarter of all births in the United States. Our findings underline the importance of birth defects surveillance programs and their utility in monitoring population-based prevalence and investigating risk factors. Birth Defects Research (Part A) 85:897-904, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Parker, Samantha E.; Mai, Cara T.; Strickland, Matthew J.; Olney, Richard S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Parker, Samantha E.; Strickland, Matthew J.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Rickard, Russel] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Marengo, Lisa; Hashmi, S. Shahrukh] Texas Dept State Hlth Serv, Austin, TX USA. [Wang, Ying] New York State Dept Hlth, Troy, NY USA. [Meyer, Robert E.] N Carolina Ctr Hlth Stat, Raleigh, NC USA. RP Parker, SE (reprint author), MSPH, 1600 Clifton Rd,MS E86, Atlanta, GA 30333 USA. EM gwf5@cdc.gov OI Hashmi, S. Shahrukh/0000-0001-8758-8254; /0000-0002-7193-077X FU National Birth Defects Prevention Network Data Committee FX The authors thank the National Birth Defects Prevention Network Data Committee and the participating investigators and programs: Russel Rickard, Colorado Responds to Children with Special Needs; Paul Romitti, Iowa Registry for Congenital and Inherited Disorders; Matthew Strickland, Metropolitan Atlanta Congenital Defects Program-Ying Wang, New York State Congenital Malformations iegistry; Robert Meyer, North Carolina Birth Defects Monitoring Program; Laureane Alvelo-Maldonado, Puerto Rico Birth Defects Surveillance System and Folic Acid Campaign; William Aries, Rhode Island Birth Defects Surveillance Program; David Law, Tennessee Birth Defects Registry; Lisa Marengo, Texas Birth Defects Epidemiology and Surveillance Branch; and Melissa Baker, West Virginia Birth Defects Surveillance System. NR 27 TC 29 Z9 30 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD NOV PY 2009 VL 85 IS 11 BP 897 EP 904 DI 10.1002/bdra.20625 PG 8 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 525GB UT WOS:000272201500005 PM 19697433 ER PT J AU Weiss, J Kotelchuck, M Grosse, SD Manning, SE Anderka, M Wyszynski, DF Cabral, H Barfield, W Garcia, R Lu, E Higgins, C AF Weiss, Judith Kotelchuck, Milton Grosse, Scott D. Manning, Susan E. Anderka, Marlene Wyszynski, Diego F. Cabral, Howard Barfield, Wanda Garcia, Raul Lu, Emily Higgins, Cathy TI Hospital Use and Associated Costs of Children Aged Zero-to-Two Years with Craniofacial Malformations in Massachusetts SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article; Proceedings Paper CT 10th Annual Meeting of the National-Birth-Defects-Prevention-Network CY FEB 04-07, 2007 CL San Antonio, TX SP Natl Birth Defects Prevent Network DE cost analysis; health services research; health care costs; children with special health care needs; craniofacial malformations ID SINGLE-SUTURE CRANIOSYNOSTOSIS; BIRTH-DEFECTS PREVENTION; OROFACIAL CLEFTS; UNITED-STATES; PALATE REPAIR; SPEECH; INFANTS; GROWTH; CARE; NEURODEVELOPMENT AB Craniofacial malformations (CFMs) are among the most common and correctable birth United States, often requiring multiple medical and surgical treatments. However, population-based data on hospital utilization and costs are sparse. METHODS: This retrospective cohort study used linked data from the Massachusetts Pregnancy to Early Life Longitudinal Data System. Cases were children born during 1998-2002 in Massachusetts hospitals to Massachusetts residents, alive at age two years, and ascertained by the Massachusetts Birth Defects Monitoring Program as having a CFM (orofacial cleft, craniosynostosis, microfia/anotia). Mean and median number of inpatient days and hospital facility costs (excluding professional fees) during birth and postbirth hospitalizations to age two years are presented by defect type and pattern for cases and compared to Massachusetts children without CFMs. RESULTS: Children with CFMs (N = 649) mostly had orofacial clefts (73%), and 73% had no other major birth defect. Both mean (12.0) and median (6) number of inpatient days from birth to age two years among children with CFMs were three times higher than among all other children. Mean incremental hospital cost of children who survived to age two years with CFMs compared to those with no CFM was $4,901 more during the birth hospitalization and $12,858 more for postbirth hospitalizations, or $17,760 overall. CONCLUSION: In the first two years of life, children with CFMs incur increased hospital costs compared to other children without such conditions, with substantial heterogeneity by defect and pattern type. Birth Defects Research (Part A) 85:925-934, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Kotelchuck, Milton] Boston Univ, Sch Publ Hlth, Dept Community Hlth Sci, Boston, MA 02118 USA. [Grosse, Scott D.; Barfield, Wanda] Ctr Dis Control & Prevent, Atlanta, GA USA. [Manning, Susan E.; Anderka, Marlene; Lu, Emily; Higgins, Cathy] Massachusetts Dept Publ Hlth, Boston, MA USA. [Wyszynski, Diego F.] Amgen Inc, Maternal & Pediat Safety, Thousand Oaks, CA 91320 USA. [Garcia, Raul] Boston Univ, Goldman Sch Dent Med, Boston, MA 02118 USA. RP Kotelchuck, M (reprint author), Boston Univ, Sch Publ Hlth, Dept Community Hlth Sci, 801 Massachusetts Ave,Crosstown Ctr,3rd Floor, Boston, MA 02118 USA. EM mkotelch@bu.edu OI Garcia, Raul/0000-0003-2153-4629; Cabral, Howard/0000-0002-1185-8331 FU NCRR NIH HHS [U54 RR024381]; NIDCR NIH HHS [U54 DE014264, K24 DE000419, U54DE019275] NR 32 TC 26 Z9 26 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD NOV PY 2009 VL 85 IS 11 BP 925 EP 934 DI 10.1002/bdra.20635 PG 10 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 525GB UT WOS:000272201500009 PM 19830851 ER PT J AU Collins, JS Canfield, MA Pearson, K Kirby, RS Case, AP Mai, CT Major, J Mulinare, J AF Collins, Julianne S. Canfield, Mark A. Pearson, Kay Kirby, Russell S. Case, Amy P. Mai, Cara T. Major, Judy Mulinare, Joe CA Natl Birth Defects Prevention Netw TI Public Health Projects for Preventing the Recurrence of Neural Tube Defects in the United States SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article; Proceedings Paper CT 10th Annual Meeting of the National-Birth-Defects-Prevention-Network CY FEB 04-07, 2007 CL San Antonio, TX SP Natl Birth Defects Prevent Network DE neural tube defect; recurrence; prevention; spina bifida; anencephaly; folic acid ID FOLIC-ACID SUPPLEMENTATION; WOMEN; KNOWLEDGE; RISK AB The recurrence risk for neural tube defects (NTDs) in subsequent pregnancies is approximately 3%, or 40 times the background risk. Prevention projects target these high-risk women to increase their folic acid consumption during the periconceptional period, a behavior which decreases their recurrence risk by at least 85%. This study surveyed birth defect surveillance programs to assess their NTD recurrence prevention activities and to identify components of intervention projects that might be implemented in states with limited resources. METHODS: In 2005, the National Birth Defects Prevention Network developed and distributed an online survey to primary state birth defects surveillance contacts for the purpose of gathering information on NTD recurrence prevention activities in the United States. RESULTS: Responses came from 37 contacts in 34 states and Puerto Rico. There were 13 active NTD recurrence prevention projects, four past projects, and three planned projects. Fifteen past and present projects recommended that women with a prior NTD-affected birth take 4.0 mg of folic acid daily, and four projects provided folic acid to the women. Reasons given for not having an NTD recurrence prevention project included staffing limitations (53%), lack of funds (47%), lack of priority (18%), and confidentiality/privacy concerns (6%). CONCLUSIONS: Only 15 states and Puerto Rico had or were planning NTD recurrence prevention projects. An NTD recurrence prevention project using minimal resources should consist of timely case ascertainment, educational materials, and mechanisms for disseminating these materials. Birth Defects Research (Part A) 85:935-938, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Collins, Julianne S.] Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA. [Canfield, Mark A.; Case, Amy P.] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA. [Pearson, Kay] Oklahoma Dept Hlth, Oklahoma Birth Defects Registry, Oklahoma City, OK USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA. [Mai, Cara T.; Mulinare, Joe] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Major, Judy] Fullerton Genet Mission Hosp, N Carolina Birth Defect Monitoring Program, Asheville, NC USA. RP Collins, JS (reprint author), Greenwood Genet Ctr, JC Self Res Inst Human Genet, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA. EM julianne@ggc.org FU PHS HHS [U50/CCU613232] NR 17 TC 4 Z9 4 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD NOV PY 2009 VL 85 IS 11 BP 935 EP 938 DI 10.1002/bdra.20619 PG 4 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 525GB UT WOS:000272201500010 PM 19626670 ER PT J AU Coughlin, SS Ekwueme, DU AF Coughlin, Steven S. Ekwueme, Donatus U. TI Breast cancer as a global health concern SO CANCER EPIDEMIOLOGY LA English DT Review DE Breast cancer; Global health; Disparities ID PREVENTING CHRONIC DISEASES; INCOME COUNTRIES; CARE; BURDEN; IMPLEMENTATION; STATISTICS; RESOURCE; AMERICA; AFRICA AB Public health data indicate that the global burden of breast cancer in women, measured by incidence, mortality, and economic costs, is substantial and on the increase. Worldwide, it is estimated that more than one million women are diagnosed with breast cancer every year, and more than 410,000 will die from the disease. in low- and middle-income countries (LMCs), the infrastructure and resources for routine screening mammography are often unavailable. In such lower resource settings, breast cancers are commonly diagnosed at late stages, and women may receive inadequate treatment, pain relief, or palliative care. There have been an increasing number of global health initiatives to address breast cancer including efforts by Susan G. Komen for the Cure (c), the Breast Health Global Initiative (BHGI), the U.S. Centers for Disease Control and Prevention (CDC), the American Cancer Society, the National Cancer Institute(NCI), and ongoing work by leading oncology societies in different parts of the world. To support such initiatives, and to provide a scientific evidence base for health policy and public health decision making, there is a need for further health services research and program evaluations. Cancer registries can be invaluable in ascertaining the magnitude of cancer disease burden and its distribution in these countries. Additional data are needed for various geographic areas to assess resources required, cost-effectiveness, and humane approaches for preventing or controlling breast cancer in low resource settings in developing countries. Published by Elsevier Ltd. C1 [Coughlin, Steven S.] Environm Epidemiol Serv, Off Publ Hlth & Environm Hazards, Dept Vet Affairs, Washington, DC USA. [Coughlin, Steven S.; Ekwueme, Donatus U.] Ctr Dis Control, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Coughlin, SS (reprint author), Environm Epidemiol Serv 135, Dept Vet Affairs, 810 Vermont Ave NW, Washington, DC 20420 USA. EM steven.coughlin@va.gov NR 38 TC 181 Z9 193 U1 7 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1877-7821 EI 1877-783X J9 CANCER EPIDEMIOL JI Cancer Epidemiol. PD NOV PY 2009 VL 33 IS 5 BP 315 EP 318 DI 10.1016/j.canep.2009.10.003 PG 4 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 538EY UT WOS:000273168300001 PM 19896917 ER PT J AU DeGue, S Widom, CS AF DeGue, Sarah Widom, Cathy Spatz TI Does Out-of-Home Placement Mediate the Relationship Between Child Maltreatment and Adult Criminality? SO CHILD MALTREATMENT LA English DT Article DE placement; foster care; crime; criminality; abuse; neglect; maltreatment ID FOSTER-CARE; DELINQUENT-BEHAVIOR; WELFARE SERVICES; PHYSICAL ABUSE; VIOLENCE; IMPACT; INVOLVEMENT; CYCLE; RISK AB Existing research on child welfare interventions as mediators of the criminal consequences of child maltreatment has focused on juvenile delinquency rather than adult criminality. This study uses a prospective sample of 772 maltreated youth to examine out-of-home placement as a mediator of adult criminality. Arrest data were collected from official records when the full sample was a mean age of 31.8, having ample opportunity for involvement with the criminal justice system. Overall, out-of-home placement showed a neutral or slightly positive effect on adult criminality compared to no placement, consistent with earlier findings. However, prior delinquency and placement instability were significant risk factors for adult criminality. Gender, not race, was identified as a significant moderator of the relationship between placement and adult criminality, with different patterns of response to placement for males and females. Thus, whether placement experiences influence adult criminal consequences of child maltreatment might depend on prior delinquency, placement stability, and gender. C1 [DeGue, Sarah] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30341 USA. [Widom, Cathy Spatz] CUNY John Jay Coll Criminal Justice, New York, NY USA. RP DeGue, S (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, 4770 Buford Highway NE,MS F63, Atlanta, GA 30341 USA. EM sdegue@cdc.gov FU NIAAA NIH HHS [AA09238, AA11108]; NICHD NIH HHS [HD40774]; NIDA NIH HHS [DA10060, DA17842]; NIMH NIH HHS [MH58386, MH49467] NR 25 TC 26 Z9 26 U1 2 U2 24 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-5595 J9 CHILD MALTREATMENT JI Child Maltreatment PD NOV PY 2009 VL 14 IS 4 BP 344 EP 355 DI 10.1177/1077559509332264 PG 12 WC Family Studies; Social Work SC Family Studies; Social Work GA 507QS UT WOS:000270870100004 PM 19258304 ER PT J AU Chaffin, M Valle, LA Funderburk, B Gurwitch, R Silovsky, J Bard, D Mccoy, C Kees, M AF Chaffin, Mark Valle, Linda Anne Funderburk, Beverly Gurwitch, Robin Silovsky, Jane Bard, David McCoy, Carol Kees, Michelle TI A Motivational Intervention Can Improve Retention in PCIT for Low-Motivation Child Welfare Clients SO CHILD MALTREATMENT LA English DT Article DE dropout; retention; parenting; PCIT; child abuse; child neglect ID SUBSTANCE-ABUSE TREATMENT; PARENT-TRAINING-PROGRAMS; PARTICIPATION; MANAGEMENT; METAANALYSIS; BARRIERS; TRIAL; SCALE; CHAOS AB A motivational orientation intervention designed to improve parenting program retention was field tested versus standard orientation across two parenting programs, Parent-Child Interaction Therapy (PCIT) and a standard didactic parent training group. Both interventions were implemented within a frontline child welfare parenting center by center staff. Participants had an average of six prior child welfare referrals, primarily for neglect. A double-randomized design was used to test main and interaction effects. The motivational intervention improved retention only when combined with PCIT (cumulative survival = 85% vs. around 61% for the three other design cells). Benefits were robust across demographic characteristics and participation barriers but were concentrated among participants whose initial level of motivation was low to moderate. There were negative effects for participants with relatively high initial motivation. The findings suggest that using a motivational intervention combined with PCIT can improve retention when used selectively with relatively low to moderately motivated child welfare clients. C1 [Chaffin, Mark; Funderburk, Beverly; McCoy, Carol] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Ctr Child Abuse & Neglect, Norman, OK 73019 USA. [Valle, Linda Anne] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Kees, Michelle] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA. [Valle, Linda Anne] Ctr Dis Control & Prevent, Div Violence Prevent, Prevent Dev & Evaluat Branch, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Bard, David] Univ Oklahoma, Ctr Child Study, Sect Dev & Behav Pediat, Norman, OK 73019 USA. [Gurwitch, Robin] Cincinnati Childrens Hosp, Med Ctr, Div Dev & Behav Pediat, Cincinnati, OH USA. RP Chaffin, M (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Ctr Child Abuse & Neglect, Norman, OK 73019 USA. EM mark-chaffin@ouhsc.edu RI Bard, David/I-6629-2012; OI Chaffin, Mark/0000-0002-3620-6583 FU NCIPC CDC HHS [R49CE622338] NR 34 TC 43 Z9 43 U1 2 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-5595 J9 CHILD MALTREATMENT JI Child Maltreatment PD NOV PY 2009 VL 14 IS 4 BP 356 EP 368 DI 10.1177/1077559509332263 PG 13 WC Family Studies; Social Work SC Family Studies; Social Work GA 507QS UT WOS:000270870100005 PM 19258303 ER PT J AU Zhang, XD Hubbs, AF Siegel, PD AF Zhang, X. D. Hubbs, A. F. Siegel, P. D. TI Changes in asthma-like responses after extended removal from exposure to trimellitic anhydride in the Brown Norway rat model SO CLINICAL AND EXPERIMENTAL ALLERGY LA English DT Article DE Brown Norway rat; IgE; persistent occupational asthma; skin; dermal exposure; trimellitic anhydride ID AIRWAY RESPONSES; GUINEA-PIGS; OCCUPATIONAL AGENTS; IMMUNOGLOBULIN-E; MURINE MODEL; SENSITIZATION; MICE; IGE; HYPERRESPONSIVENESS; INFLAMMATION AB P>Background Organic acid anhydride-induced occupational asthma is considered to be IgE-mediated. Airway and skin exposure are the two main routes of sensitization in the work place. Recently we developed an allergic asthmatic Brown Norway rat model sensitized by dermal exposure to trimellitic anhydride (TMA) using an occlusion patch application. Objectives The objectives of this study were (1) to develop a model of non-occluded dermal exposure leading to allergic sensitization and (2) to examine the effect of extended removal from exposure on persistence of both specific IgE and TMA aerosol-induced airway responses in this model. Methods TMA powder (4 or 40 mg) was applied, unoccluded, to the skin of rats for 4 h, once/week for 4 weeks. Rats were given a 10-min aerosol challenge to 40 mg/m3 TMA 2 weeks after the last dermal exposure (day 35). Another group was challenged on day 35 and again 18-24 months later. Respiratory enhanced pause (Penh), pulmonary histopathology and inflammation and specific IgE titres were measured. Results Rats produced dose-dependent specific IgE titres after exposure and developed early-phase (EAR) and late-phase airway responses (LAR) after airway challenge to TMA aerosol as well as airway eosinophilic inflammation. Specific airway responses were still manifested after a second TMA airway challenge given 18-24 months following the initial airway challenge. While persistent, airway inflammation, specific IgE and EAR were significantly attenuated following the second TMA challenge. LAR remained robust at 18-24 months and was not significantly different from the response on day 35. Conclusions These results demonstrate the persistence of chemical sensitization and further suggest that IgE is not essential for LAR. Cite this as: X. D. Zhang, A. F. Hubbs and P. D. Siegel, Clinical & Experimental Allergy, 2009 (39) 1746-1753. C1 [Siegel, P. D.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Siegel, PD (reprint author), NIOSH, Ctr Dis Control & Prevent, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM Psiegel@cdc.gov NR 35 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0954-7894 J9 CLIN EXP ALLERGY JI Clin. Exp. Allergy PD NOV PY 2009 VL 39 IS 11 BP 1746 EP 1753 DI 10.1111/j.1365-2222.2009.03304.x PG 8 WC Allergy; Immunology SC Allergy; Immunology GA 509FY UT WOS:000271001600017 PM 19549025 ER PT J AU Ramonda, R Musacchio, E Perissinotto, E Sartori, L Punzi, L Corti, MC Hirsch, R Manzato, E Zambon, S Baggio, G Crepaldi, G AF Ramonda, R. Musacchio, E. Perissinotto, E. Sartori, L. Punzi, L. Corti, M. C. Hirsch, R. Manzato, E. Zambon, S. Baggio, G. Crepaldi, G. TI Prevalence of chondro-calcinosis in Italian subjects from northeastern Italy. The Pro.VA (PROgetto Veneto Anziani) Study SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY LA English DT Article DE Chondrocalcinosis; epidemiology; x-rays; joint disease ID DEPOSITION DISEASE; CHONDROCALCINOSIS; OSTEOARTHRITIS; ASSOCIATION; HYPOMAGNESEMIA; SAMPLE AB Objectives. To undertake an epidemiological survey of the prevalence of radiological chondrocalcinosis (CC) of the lower limbs in the elderly Italian population of the Pro. VA. study. Methods. Knee and pelvic basin radiographs were performed on 3099 subjects aged 65 and older, residing in the Veneto Region of Italy (Rovigo and Camposampiero areas). Two readers independently analysed the knee, coxofemoral and pubic symphysis x-rays of a consecutive sample of 1629 subjects according to Altman. Some laboratory indexes, such as serum parathyroid hormone (PTH), vitamin D (vit D), bone alkaline phosphatase (bALP), deyidroepiandrosterone (DHEA), urinary CrossLaps (XL), and inflammatory biomarkers were evaluated. Quantitative variables were summarised as mean standard deviation and qualitative ones as distributions. Unpaired t-test was used to compare mean values among groups for normally distributed variables, and non-parametric Mann-Whitney test for non normal variables. Results. CC was found in 169 (mean age 78.2 +/- 8.0 yrs) out of the 1629 subjects studied (10.4%). After adjusting for the sex and age structure of the target population, the prevalence was 10.0%. CC was more often observed in women than in men (M: 7.0%; F: 12.8%, p=0.0002), and increased in occurrence with age, rising from, 7.8% in subjects aged 65-74 yrs, to 9.4% in those aged 75-84 yrs, and to 21.1% in subjects older than 85 yrs. The knee was the most prevalent location since it was affected in 94.1% of all the subjects with CC, in particular the right limb. Knee CC was bilateral in 71.7% of the affected patients. The occurrence of rheumatic disorders did not differ significantly between the subjects with CC and those without (rheumatoid arthritis 0.59% vs. 0.48%, p=ns). Conclusions. Although the detection of CC was limited to few joints with the knee being the most affected location, our study confirms the frequent presence of CC at different sites, in keeping with the possible role of systemic factors. Articular CC is an age-related disorder, which could partly explain the prevalence discrepancies reported by various studies. The prevalence of CC found in our survey based on standardised x-ray reading was high, suggesting that CC could be an under-diagnosed disease in the absence of radiographic investigation. C1 [Ramonda, R.] Univ Padua, Azienda Ospdaliera, Rheumatol Unit, Dept Clin & Expt Med,Cattedra & Div Reumatol, I-35128 Padua, Italy. [Musacchio, E.; Sartori, L.; Zambon, S.] Univ Padua, Dipartimento Sci Med & Chirurg, Med Clin 1, I-35128 Padua, Italy. [Perissinotto, E.] Univ Padua, Dipartimento Med Ambientale & Sanita Pubbl, I-35128 Padua, Italy. [Hirsch, R.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Manzato, E.] Univ Padua, Clin Geriatr, Dipartimento Sci Med & Chirurg, I-35128 Padua, Italy. [Manzato, E.; Baggio, G.] CNR, Ist Neurosci, Padua, Italy. RP Ramonda, R (reprint author), Univ Padua, Azienda Ospdaliera, Rheumatol Unit, Dept Clin & Expt Med,Cattedra & Div Reumatol, Via Giustiniani 2, I-35128 Padua, Italy. EM roberta.ramonda@unipd.it OI PUNZI, LEONARDO/0000-0002-8853-516X FU Fondazione Cassa di Risparmio di Padova e Rovigo FX The Pro.V.A. study was supported by the Fondazione Cassa di Risparmio di Padova e Rovigo. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers of Disease Control and Prevention. NR 16 TC 22 Z9 22 U1 0 U2 1 PU CLINICAL & EXPER RHEUMATOLOGY PI PISA PA VIA SANTA MARIA 31, 56126 PISA, ITALY SN 0392-856X J9 CLIN EXP RHEUMATOL JI Clin. Exp. Rheumatol. PD NOV-DEC PY 2009 VL 27 IS 6 BP 981 EP 984 PG 4 WC Rheumatology SC Rheumatology GA 552CO UT WOS:000274264700015 PM 20149316 ER PT J AU Peto, HM Pratt, RH Harrington, TA LoBue, PA Armstrong, LR AF Peto, Heather M. Pratt, Robert H. Harrington, Theresa A. LoBue, Philip A. Armstrong, Lori R. TI Epidemiology of Extrapulmonary Tuberculosis in the United States, 1993-2006 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID EXTRA-PULMONARY TUBERCULOSIS; MANIFESTATIONS; INFECTION; RISK; HIV AB Background. Almost one-fifth of United States tuberculosis cases are extrapulmonary; unexplained slower annual case count decreases have occurred in extrapulmonary tuberculosis (EPTB), compared with annual case count decreases in pulmonary tuberculosis (PTB) cases. We describe the epidemiology of EPTB by means of US national tuberculosis surveillance data. Methods. US tuberculosis cases reported from 1993 to 2006 were classified as either EPTB or PTB. EPTB encompassed lymphatic, pleural, bone and/or joint, genitourinary, meningeal, peritoneal, and unclassified EPTB cases. We excluded cases with concurrent extrapulmonary-pulmonary tuberculosis and cases of disseminated (miliary) tuberculosis. Demographic characteristics, drug susceptibility test results, and risk factors, including human immunodeficiency virus (HIV) status, were compared for EPTB and PTB cases. Results. Among 253,299 cases, 73.6% were PTB and 18.7% were EPTB, including lymphatic (40.4%), pleural (19.8%), bone and/or joint (11.3%), genitourinary (6.5%), meningeal (5.4%), peritoneal (4.9%), and unclassified EPTB (11.8%) cases. Compared with PTB, EPTB was associated with female sex (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.7-1.8) and foreign birth (OR, 1.5; CI, 1.5-1.6), almost equally associated with HIV status (OR, 1.1; CI, 1.1-1.1), and negatively associated with multidrug resistance (OR, 0.6; CI, 0.5-0.6) and several tuberculosis risk factors, especially homelessness (OR, 0.3; CI, 0.3-0.3) and excess alcohol use (OR, 0.3; CI, 0.3-0.3). Slower annual decreases in EPTB case counts, compared with annual decreases in PTB case counts, from 1993 through 2006 have caused EPTB to increase from 15.7% of tuberculosis cases in 1993 to 21.0% in 2006. Conclusions. EPTB epidemiology and risk factors differ from those of PTB, and the proportion of EPTB has increased from 1993 through 2006. Further study is needed to identify causes of the proportional increase in EPTB. C1 [Peto, Heather M.; Pratt, Robert H.; Harrington, Theresa A.; LoBue, Philip A.; Armstrong, Lori R.] Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, Atlanta, GA 30333 USA. [Peto, Heather M.] Ctr Dis Control & Prevent, CDC Experience Program, Atlanta, GA 30333 USA. [Pratt, Robert H.] Northrop Grumman Informat Technol, Mclean, VA USA. RP Peto, HM (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, 1600 Clifton Rd,Mailstop E-10, Atlanta, GA 30333 USA. EM hmpeto@gmail.com NR 41 TC 180 Z9 191 U1 0 U2 14 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV PY 2009 VL 49 IS 9 BP 1350 EP 1357 DI 10.1086/605559 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 506KH UT WOS:000270773200010 PM 19793000 ER PT J AU Weaver, JB Thompson, N Weaver, SS Hopkins, GL AF Weaver, James B., III Thompson, Nancy. Weaver, Stephanie Sargent Hopkins, Gary L. TI Healthcare non-adherence decisions and internet health information SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Adherence; Compliance; Health information; Internet; Risk perception ID PERCEIVED RISK; LONG-TERM; MOTIVATORS; BEHAVIORS; FRAMEWORK; CONSUMERS; EFFICACY; SEEKING; ASTHMA AB While the internet is emerging as an important transforming mechanism for health care and public health, questions remain about its limitations. Growing evidence indicates that a significant proportion of internet health information consumers is engaging treatment strategies inconsistent with professional recommendations. This study aimed to distinguish internet users who report non-adherence behavior from their counterparts based on several personal and environmental determinants. Using information obtained via the internet to refuse or discontinue treatment recommended by a doctor or dentist proved to be a widespread (11.2%) behavior. Internet health information bolstered non-adherence appears strongly linked with personal determinants such as anxiety, diminishing health, and gender - a pattern consistent with prior adherence research - and with environmental determinants including the perceived importance of both internet health information and internet-facilitated interpersonal interactions as well as using the internet as a social support vehicle. Published by Elsevier Ltd. C1 [Weaver, James B., III; Weaver, Stephanie Sargent] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA. [Thompson, Nancy.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Hopkins, Gary L.] Andrews Univ, Ctr Media Impact Res, Ctr Prevent Res, Berrien Springs, MI 49104 USA. RP Weaver, JB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, 1600 Clifton Rd MS-E21, Atlanta, GA 30333 USA. EM Jim.Weaver@CDC.GOV NR 45 TC 17 Z9 17 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD NOV PY 2009 VL 25 IS 6 BP 1373 EP 1380 DI 10.1016/j.chb.2009.05.011 PG 8 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 504OW UT WOS:000270627500021 ER PT J AU Kahn, HS Lawrence, JM Morgan, TM Marcovina, SM Case, LD Imperatore, G Dabelea, D Mayer-Davis, EJ AF Kahn, Henry S. Lawrence, Jean M. Morgan, Timothy M. Marcovina, Santica M. Case, L. Douglas Imperatore, Giuseppina Dabelea, Dana Mayer-Davis, Elizabeth J. CA SEARCH Diabet Youth Study Grp TI Association of Type 1 Diabetes With Month of Birth Among US Youth The SEARCH for Diabetes in Youth Study SO DIABETES CARE LA English DT Article ID COD-LIVER OIL; VITAMIN-D; UNITED-STATES; LOWER RISK; SEASONALITY; CHILDREN; MELLITUS; ONSET; PREVALENCE; PANCREAS AB OBJECTIVE - Seasonal environment at birth may influence diabetes incidence in later life. We sought evidence for this effect in a large sample of diabetic youth residing in the U.S. RESEARCH DESIGN AND METHODS - We compared the distribution of birth months within the SEARCH for Diabetes in Youth Study (SEARCH study) with the monthly distributions in U.S. births tabulated by race for years 1982-2005. SEARCH study participants (9,737 youth with type 1 diabetes and 1,749 with type 2 diabetes) were identified by six collaborating U.S. centers. RESULTS - Among type 1 diabetic youth, the percentage of observed to expected births differed across the months (P = 0.0092; decreased in October-February and increased in March July). Their smoothed birth-month estimates demonstrated a deficit in November-February births and an excess in April July births (smoothed May Versus January relative risk [RR] = 1.06 [95% CI 1.02-1.11]). Stratifications by sex or by three racial groups showed similar patterns relating type 1 diabetes to month of birth. Stratification by geographic regions showed a peak-to-nadir RR of 1.10 [1.04-1.16] in study regions from the northern latitudes (Colorado, western Washington State, and southern Ohio) but no birth-month effect (P > 0.9) in study regions from more southern locations. Among type 2 diabetic youth, associations with birth month were inconclusive. CONCLUSIONS - Spring births were associated with increased likelihood of type 1 diabetes but possibly not in all U.S. regions. Causal mechanisms may involve factors dependent on geographic latitude such as solar irradiance, but it is unknown whether they influence prenatal or early postnatal development. C1 [Kahn, Henry S.; Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30333 USA. [Morgan, Timothy M.; Case, L. Douglas] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC USA. [Dabelea, Dana] Univ Colorado Denver, Dept Epidemiol, Colorado Sch Publ Hlth, Aurora, CO USA. [Mayer-Davis, Elizabeth J.] Univ S Carolina, Ctr Res Nutr & Hlth Dispar, Columbia, SC 29208 USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA. [Lawrence, Jean M.] Kaiser Permanente So Calf, Dept Res & Evaluat, Pasadena, CA USA. [Marcovina, Santica M.] Univ Washington, Dept Med, Seattle, WA USA. RP Kahn, HS (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30333 USA. EM hkahn@cdc.gov OI Kahn, Henry/0000-0003-2533-1562 FU Centers for Disease Control and Prevention [00097, DP-05-069]; National Institute of Diabetes and Digestive and Kidney Diseases FX Acknowledgments-SEARCH for Diabetes in Youth is funded by the Centers for Disease Control and Prevention (PA number 00097 and DP-05-069) and supported by the National Institute of Diabetes and Digestive and Kidney Diseases. Site contract numbers are as follows: Kaiser Permanente Southern California, U01 DP-000246; University of Colorado Health Sciences Center, U01 DP-000247; Pacific Health Research Institute, U01 DP-000245; Children's Hospital Medical Center (Cincinnati), U01 DP-000248; University of North Carolina at Chapel Hill, U01 DP-000254; University of Washington School of Medicine, U01 DP-000244; and Wake Forest University School of Medicine, U01 DP-000250. NR 25 TC 34 Z9 36 U1 0 U2 4 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD NOV PY 2009 VL 32 IS 11 BP 2010 EP 2015 DI 10.2337/dc09-0891 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 518HW UT WOS:000271682800012 PM 19675199 ER PT J AU Cheng, YJ Gregg, EW Geiss, LS Imperatore, G Williams, DE Zhang, XZ Albright, AL Cowie, CC Klein, R Saaddine, JB AF Cheng, Yiling J. Gregg, Edward W. Geiss, Linda S. Imperatore, Giuseppina Williams, Desmond E. Zhang, Xinzhi Albright, Ann L. Cowie, Catherine C. Klein, Ronald Saaddine, Jinan B. TI Association of A1C and Fasting Plasma Glucose Levels With Diabetic Retinopathy Prevalence in the US Population Implications for diabetes diagnostic thresholds SO DIABETES CARE LA English DT Article ID PREVENTION PROGRAM; HEMOGLOBIN A(1C); BLOOD-GLUCOSE; MELLITUS; CRITERIA; TOLERANCE; HBA(1C); TESTS AB OBJECTIVE - To examine the association of A1C levels and fasting plasma glucose (FPG) with diabetic retinopathy in the U.S. population and to compare the ability of the two glycemic measures to discriminate between people with and without retinopathy. RESEARCH DESIGN AND METHODS - This study included 1,066 individuals aged >= 40 years from the 2005-2006 National Health and Nutrition Examination Survey. A1C, FPG, and 45 color digital retinal images were assessed. Retinopathy was defined as a level >= 1.4 on the Early Treatment Diabetic Retinopathy Study severity scale. We used joinpoint regression to identify linear inflections of prevalence of retinopathy in the association between A1C and FPG. RESULTS - The overall prevalence of retinopathy was 11%, which is appreciably lower than the prevalence in people with diagnosed diabetes (36%). There was a sharp increase in retinopathy prevalence in those with A1C >= 5.5% or FPG >= 5.8 mmol/l. After excluding 144 people using hypoglycemic medication, the change points for the greatest increase in retinopathy prevalence were A1C 5.5% and FPG 7.0 mmol/l. The coefficients of variation were 15.6 for A1C and 28.8 for FPG. Based on the areas under the receiver operating characteristic curves, A1C was a stronger discriminator of retinopathy (0.71 [95% CI 0.66-0.76]) than FPG (0.65 [0.60 - 0.701, P for difference = 0.009). CONCLUSIONS - The steepest increase in retinopathy prevalence occurs among individuals with A1C >= 5.5% and FPG >= 5.8 mmol/l. A1C discriminates prevalence of retinopathy better than FPG. C1 [Cheng, Yiling J.; Gregg, Edward W.; Geiss, Linda S.; Imperatore, Giuseppina; Williams, Desmond E.; Zhang, Xinzhi; Albright, Ann L.; Saaddine, Jinan B.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Cowie, Catherine C.] NIDDKD, Bethesda, MD 20892 USA. [Klein, Ronald] Univ Wisconsin, Sch Med & Publ Hlth, Dept Ophthalmol & Visual Sci, Madison, WI USA. RP Cheng, YJ (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM ycheng@cdc.gov OI Klein, Ronald/0000-0002-4428-6237 NR 25 TC 63 Z9 66 U1 1 U2 6 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD NOV PY 2009 VL 32 IS 11 BP 2027 EP 2032 DI 10.2337/dc09-0440 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 518HW UT WOS:000271682800015 PM 19875604 ER PT J AU Lyons, JM Igietseme, JU Black, CM Morre, SA AF Lyons, J. M. Igietseme, J. U. Black, C. M. Morre, S. A. TI IDENTIFICATION OF CANDIDATE GENES USING THE MURINE MODEL OF FEMALE GENITAL TRACT INFECTION WITH CHLAMYDIA TRACHOMATIS SO DRUGS OF TODAY LA English DT Article ID NITRIC-OXIDE SYNTHASE; KNOCKOUT MICE; MOUSE PNEUMONITIS; GAMMA-INTERFERON; DEFICIENT MICE; IFN-GAMMA; PROTECTIVE IMMUNITY; RECEPTOR; CELLS; CLEARANCE AB The integrated approach to the study of female genital tract infection (GTI) with Chlamydia trachomatis is a conceptual-framework through which a consistent and comprehensive evidence-based understanding of C. trachomatis GTI could evolve. One application of this approach has been to identify candidate genes that may play a role in the course and severity of C. trachomatis GTI in women, using human clinical and genetic data together with results obtained in e the female mouse model to guide the selection process. This model has been proven robust enough: i) to identify stable phenotypic differences in the course and outcome of GTI among commonly used immunocompetent inbred mouse stains that ore used in the construction of gene knockout (KO) and transgenic mice; as well as ii) to serve as a platform in which to assess the influence of genetic differences among human genital tract isolates of C. trachomatis as well as between this biovar and the mouse biovar, Chlamydia muridarum. This review presents a summary of published and unpublished results from 25 years of studies in immunodeficient and gene-deficient KO mice that both inform our present understanding of the immunogenetics of C. trachomatis GTI and serve to guide candidate gene selection. C1 [Lyons, J. M.] Integrated Dis Modeling, Claremont, CA 91711 USA. [Igietseme, J. U.; Black, C. M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Morre, S. A.] Vrije Univ Amsterdam, Med Ctr, Immunogenet Lab, Dept Pathol,Sect Immunogenet Infect Dis, Amsterdam, Netherlands. RP Lyons, JM (reprint author), Integrated Dis Modeling, 1774 Chatham Court, Claremont, CA 91711 USA. EM jlyons001@msn.com FU European Commission [LSHG-CT-2007-037637] FX The aims of this work are in line with the European EpiGenChlamydia Consortium which is supported by the European Commission within the Sixth Framework Programme through contract no. LSHG-CT-2007-037637. See www.EpiGenChlamydia.eu for more details about this Consortium. NR 45 TC 4 Z9 4 U1 0 U2 1 PU PROUS SCIENCE, SA PI BARCELONA PA PO BOX 540, PROVENZA 388, 08025 BARCELONA, SPAIN SN 1699-3993 J9 DRUG TODAY JI Drugs Today PD NOV PY 2009 VL 45 BP 51 EP 59 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 522RD UT WOS:000272015100009 PM 20011695 ER PT J AU Brown, CR Padhi, A Moore, AT Brown, MB Foster, JE Pfeffer, M O'Brien, VA Komar, N AF Brown, Charles R. Padhi, Abinash Moore, Amy T. Brown, Mary Bomberger Foster, Jerome E. Pfeffer, Martin O'Brien, Valerie A. Komar, Nicholas TI Ecological divergence of two sympatric lineages of Buggy Creek virus, an arbovirus associated with birds SO ECOLOGY LA English DT Article DE alphavirus; Cliff Swallow; disease emergence; host-pathogen dynamics; House Sparrow; infectious disease; Oeciacus vicarius; Passer domesticus; Petrochelidon pyrrhonota; vector biology; virus ecology; virus evolution ID FORT-MORGAN VIRUS; TIME RT-PCR; EQUINE ENCEPHALOMYELITIS COMPLEX; VICARIUS HEMIPTERA CIMICIDAE; WESTERN GREAT-PLAINS; OECIACUS-VICARIUS; CLIFF SWALLOWS; DENGUE VIRUS; EVOLUTIONARY RELATIONSHIPS; TOGAVIRIDAE ALPHAVIRUS AB Most arthropod-borne viruses (arboviruses) show distinct serological subtypes or evolutionary lineages, with the evolution of different strains often assumed to reflect differences in ecological selection pressures. Buggy Creek virus (BCRV) is an unusual RNA virus (Togaviridae, Alphavirus) that is associated primarily with a cimicid swallow bug (Oeciacus vicarius) as its vector and the Cliff Swallow (Petrochelidon pyrrhonota) and the introduced House Sparrow (Passer domesticus) as its amplifying hosts. There are two sympatric lineages of BCRV (lineages A and B) that differ from each other by >6% at the nucleotide level. Analysis of 385 BCRV isolates all collected from bug vectors at a study site in southwestern Nebraska, USA, showed that the lineages differed in their peak times of seasonal occurrence within a summer. Lineage A was more likely to be found at recently established colonies, at those in culverts (rather than on highway bridges), and at those with invasive House Sparrows, and in bugs on the outsides of nests. Genetic diversity of lineage A increased with bird colony size and at sites with House Sparrows, while that of lineage B decreased with colony size and was unaffected by House Sparrows. Lineage A was more cytopathic on mammalian cells than was lineage B. These two lineages have apparently diverged in their transmission dynamics, with lineage A possibly more dependent on birds and lineage B perhaps more a bug virus. The long-standing association between Cliff Swallows and BCRV may have selected for immunological resistance to the virus by swallows and thus promoted the evolution of the more bug-adapted lineage B. In contrast, the recent arrival of the introduced House Sparrow and its high competence as a BCRV amplifying host may be favoring the more bird-dependent lineage A. C1 [Brown, Charles R.; Padhi, Abinash; Moore, Amy T.; Brown, Mary Bomberger; Foster, Jerome E.; O'Brien, Valerie A.] Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA. [Pfeffer, Martin] Bundeswehr Inst Microbiol, D-80937 Munich, Germany. [Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. RP Brown, CR (reprint author), Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA. EM charles-brown@utulsa.edu FU National Institutes of Health [R01-AI057569]; National Science Foundation [IBN-9974733, DEB-0075199, DEB-0514824] FX For field and laboratory assistance, we thank Susan Beckett, Jillian Blackwell, Eric Edwards, Kathryn Gaines, Allison Johnson, Jennifer Klaus, Sarah Knutie, Matt Moore, Cheryl Ormston, Nicholas Panella, Sunita Quick, Sara Robinson, Rajni Sethi, Stephanie Strickler, Karen Winans, and Gudrun Zoller. Kenton Miller and several anonymous reviewers made useful comments on the manuscript. The School of Biological Sciences at the University of Nebraska-Lincoln allowed us to use the Cedar Point Biological Station, and the Union Pacific Railroad and the Robert Clary, Dave Knight, and Loren Soper families allowed us access to land. This work was supported by grants from the National Institutes of Health (R01-AI057569) and the National Science Foundation (IBN-9974733, DEB-0075199, DEB-0514824). NR 81 TC 11 Z9 11 U1 1 U2 6 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 0012-9658 EI 1939-9170 J9 ECOLOGY JI Ecology PD NOV PY 2009 VL 90 IS 11 BP 3168 EP 3179 DI 10.1890/08-1731.1 PG 12 WC Ecology SC Environmental Sciences & Ecology GA 515GY UT WOS:000271457300020 PM 19967872 ER PT J AU Arguin, PM Marano, N Freedman, DO AF Arguin, Paul M. Marano, Nina Freedman, David O. TI Globally Mobile Populations and the Spread of Emerging Pathogens SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 [Arguin, Paul M.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Freedman, David O.] Univ Alabama, Birmingham, AL USA. RP Arguin, PM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, 4770 Buford Hwy NE,Mailstop F22, Atlanta, GA 30341 USA. EM parguin@cdc.gov NR 10 TC 17 Z9 22 U1 0 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1713 EP 1714 DI 10.3201/eid1511.091426 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600001 PM 19891855 ER PT J AU Yanni, EA Marano, N Stauffer, WM Barnett, ED Cano, M Cetron, MS AF Yanni, Emad A. Marano, Nina Stauffer, William M. Barnett, Elizabeth D. Cano, Maria Cetron, Martin S. TI Health Status of Visitors and Temporary Residents, United States SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CHILDREN; TUBERCULOSIS; CALIFORNIA; DISEASES; MIGRANT; RISKS; FARMWORKERS; POPULATION; FAMILIES; WORKERS AB Human mobility has always been associated with the spread of infection, and mobility of nonimmigrant visitors and temporary residents to the United States is increasing, from approximate to 12 million in 1987 to approximate to 37 million in 2007. Lack of information about the health status of these populations upon arrival and their need for and use of medical services in the United States hinders development of public health policy, education, and provision of adequate clinical care. After these issues and needs are clarified, intervention programs should be developed to increase access and decrease the disparities of care experienced by these populations. C1 [Yanni, Emad A.; Marano, Nina; Stauffer, William M.; Cano, Maria; Cetron, Martin S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Stauffer, William M.] Univ Minnesota, Minneapolis, MN USA. [Barnett, Elizabeth D.] Boston Med Ctr, Boston, MA USA. RP Yanni, EA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E03, Atlanta, GA 30333 USA. EM eyanni@cdc.gov OI Barnett, Elizabeth/0000-0003-4822-5949 NR 40 TC 4 Z9 4 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1715 EP 1720 DI 10.3201/eid1511.090938 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600002 PM 19891856 ER PT J AU Chen, LH Wilson, ME Davis, X Loutan, L Schwartz, E Keystone, J Hale, D Lim, PL McCarthy, A Gkrania-Klotsas, E Schlagenhauf, P AF Chen, Lin H. Wilson, Mary E. Davis, Xiaohong Loutan, Louis Schwartz, Eli Keystone, Jay Hale, Devon Lim, Poh Lian McCarthy, Anne Gkrania-Klotsas, Effrossyni Schlagenhauf, Patricia CA GeoSentinel Surveillance Network TI Illness in Long-Term Travelers Visiting GeoSentinel Clinics SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PEACE-CORPS VOLUNTEERS; HEPATITIS-B; AMERICAN MISSIONARIES; HEALTH KNOWLEDGE; DENGUE VIRUS; RISK; ATTITUDES; MALARIA; TUBERCULOSIS; PREVENTION AB Length of travel appears to be associated with health risks. GeoSentinel Surveillance Network data for 4,039 long-term travelers (trip duration >6 months) seen after travel during June 1, 1996, through December 31, 2008, were compared with data for 24,807 short-term travelers (trip duration 1 month). Long-term travelers traveled more often than short-term travelers for volunteer activities (39.7% vs. 7.0%) and business (25.2% vs. 13.8%). More long-term travelers were men (57.2% vs. 50.1%) and expatriates (54.0% vs. 8.9%); most had pretravel medical advice (70.3% vs. 48.9%). Per 1,000 travelers, long-term travelers more often experienced chronic diarrhea, giardiasis, Plasmodium falciparum and P. vivax malaria, irritable bowel syndrome (postinfectious), fatigue >1 month, eosinophilia, cutaneous leishmaniasis, schistosomiasis, and Entamoeba histolytica diarrhea. Areas of concern for long-term travelers were vector-borne diseases, contact-transmitted diseases, and psychological problems. Our results can help prioritize screening for and diagnosis of illness in long-term travelers and provide evidence-based pretravel advice. C1 [Chen, Lin H.] Mt Auburn Hosp, Travel Med Ctr, Cambridge, MA 02138 USA. [Chen, Lin H.] Harvard Univ, Sch Med, Boston, MA USA. [Davis, Xiaohong] Ctr Dis Control & Prevent, Atlanta, GA USA. [Loutan, Louis] Univ Geneva, Geneva, Switzerland. [Schwartz, Eli] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel. [Keystone, Jay] Toronto Gen Hosp, Toronto, ON, Canada. [Hale, Devon] Univ Utah, Salt Lake City, UT USA. [Lim, Poh Lian] Tan Tock Seng Hosp, Singapore, Singapore. [McCarthy, Anne] Univ Ottawa, Ottawa, ON, Canada. [Gkrania-Klotsas, Effrossyni] Univ Cambridge, Cambridge, England. [Schlagenhauf, Patricia] Univ Zurich, Zurich, Switzerland. RP Chen, LH (reprint author), Mt Auburn Hosp, Travel Med Ctr, 330 Mt Auburn St, Cambridge, MA 02138 USA. EM lchen@hms.harvard.edu OI McCarthy, Anne/0000-0001-7195-6366; Barnett, Elizabeth/0000-0003-4822-5949; Gkrania-Klotsas, Effrossyni/0000-0002-0930-8330 FU US Centers for Disease Control and Prevention [U50/CCU412347]; National Institute for Health Research (NIHR) Biomedical Research Centre FX Dr Chen directs the Travel Medicine Center at Mount Auburn Hospital and is assistant clinical professor at Harvard Medical School. Her clinical interests include malaria, dengue, travelers' health, and travel-associated emerging infections. NR 35 TC 47 Z9 48 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1773 EP 1782 DI 10.3201/eid1511.090945 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600011 PM 19891865 ER PT J AU Jensenius, M Davis, X von Sonnenburg, F Schwartz, E Keystone, JS Leder, K Lopez-Velez, R Caurnes, E Cramer, JP Chen, L Parola, P AF Jensenius, Mogens Davis, Xiaohong von Sonnenburg, Frank Schwartz, Eli Keystone, Jay S. Leder, Karin Lopez-Velez, Rogelio Caurnes, Eric Cramer, Jakob P. Chen, Lin Parola, Philippe CA GeoSentinel Surveillance Network TI Multicenter GeoSentinel Analysis of Rickettsial Diseases in International Travelers, 1996-2008 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TICK BITE FEVER; HUMAN GRANULOCYTIC EHRLICHIOSIS; SPOTTED-FEVER; MURINE TYPHUS; RETURNED TRAVELERS; SCRUB TYPHUS; AFRICA; INFECTIONS; SPECTRUM C1 [Jensenius, Mogens] Oslo Univ Hosp, Dept Infect Dis, NO-0407 Oslo, Norway. [Jensenius, Mogens] Univ Oslo, Oslo, Norway. [Davis, Xiaohong] Ctr Dis Control & Prevent, Atlanta, GA USA. [von Sonnenburg, Frank] Univ Munich, Munich, Germany. [Schwartz, Eli] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel. [Keystone, Jay S.] Toronto Gen Hosp, Toronto, ON, Canada. [Leder, Karin] Royal Melbourne Hosp, Parkville, Vic 3050, Australia. [Lopez-Velez, Rogelio] Hosp Ramon & Cajal, E-28034 Madrid, Spain. [Caurnes, Eric] Hop La Pitie Salpetriere, Paris, France. [Cramer, Jakob P.] Bernhard Nocht Clin Trop Med, Hamburg, Germany. [Chen, Lin] Harvard Univ, Sch Med, Boston, MA USA. [Parola, Philippe] WHO Collaborat Ctr Rickettsioses & Other Arthropo, Marseille, France. [Parola, Philippe] Hop Nord Marseille, Marseille, France. RP Jensenius, M (reprint author), Oslo Univ Hosp, Dept Infect Dis, NO-0407 Oslo, Norway. EM mogens.jensenius@ioks.uio.no OI Leder, Karin/0000-0003-1368-1039; Gkrania-Klotsas, Effrossyni/0000-0002-0930-8330 FU Centers for Disease Control and Prevention [U50/CCU412347] FX GeoSentinel, the Global Surveillance Network of the International Society of Travel Medicine, is supported by Cooperative Agreement U50/CCU412347 from the Centers for Disease Control and Prevention. NR 35 TC 60 Z9 61 U1 2 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1791 EP 1798 DI 10.3201/eid1511.090677 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600013 PM 19891867 ER PT J AU Potter, P AF Potter, Polyxeni TI Put Me in the Sky SO EMERGING INFECTIOUS DISEASES LA English DT News Item C1 Ctr Dis Control & Prevent, EID Journal, Atlanta, GA 30333 USA. RP Potter, P (reprint author), Ctr Dis Control & Prevent, EID Journal, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM PMP1@cdc.gov NR 8 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2009 VL 15 IS 11 BP 1884 EP 1885 DI 10.3201/eid1511.000000 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 518ML UT WOS:000271696600048 PM 19891901 ER PT J AU Ye, XY Wong, LY Jia, LT Needham, LL Calafat, AM AF Ye, Xiaoyun Wong, Lee-Yang Jia, Lily T. Needham, Larry L. Calafat, Antonia M. TI Stability of the conjugated species of environmental phenols and parabens in human serum SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Conjugated metabolites; Serum; Exposure; Environmental phenols; Parabens; Bisphenol A ID PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; BISPHENOL-A; MASS-SPECTROMETRY; US POPULATION; UNITED-STATES; METABOLISM; EXPOSURE; RATS; BENZOPHENONE-3 AB I humans, the metabolism of environmental phenols may include the formation of conjugated species e.g., glucuronides and sulfates), but the free species-not the conjugated forms-are considered biologically active. Therefore, information on the concentration of these free species in blood or urine could be helpful for risk assessment. Because conjugates could hydrolyze to their corresponding free forms during collection, handling, and storage of biological specimens, information on the temporal stability of the conjugates is of interest. Previously, we reported the temporal stability of urinary conjugates of several environmental phenols, but data on the stability of phenols' conjugated species in serum, albeit critical if concentrations of free and conjugated species are compared. are largely unknown. In the present study, we investigate the stability of the conjugates of four phenols-bisphenol A, benzophenone-3, triclosan, and 2,5-dichlorophenol-and two parabens-methyl paraben and propyl paraben-in 16 human serum samples for 30 days at above-freezing temperature storage conditions (4 degrees C, room temperature, and 37 degrees C). These conditions reflect the worst-case scenarios that could occur during the short-term storage of biological samples before their long-term storage at controlled subfreezing temperatures. We found that the percentage of the conjugated species of the four detected compounds (2,5-dichlorophenol, triclosan, and methyl and propyl parabens) in these serum specimens even when stored at 37 degrees C for at least 30 days did not vary significantly. These preliminary data suggest that the phenols' serum conjugates appear to be more stable than their corresponding urinary conjugates. some of which started to hydrolyze within 24 h under similar storage conditions. The reported stability of these conjugated species in human serum also suggests that the free species are unlikely to have resulted from the hydrolysis of their corresponding conjugates. This information could be important for interpreting the low concentrations of free phenol species detected in serum samples of nonoccupationally exposed populations. To our knowledge, this is the first study to report on the stability of conjugated species in serum, and as such requires replication, Published by Elsevier Ltd. C1 [Ye, Xiaoyun; Wong, Lee-Yang; Jia, Lily T.; Needham, Larry L.; Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Ye, XY (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy,Mailstop F53, Atlanta, GA 30341 USA. EM xay5@cdc.gov RI Needham, Larry/E-4930-2011 NR 31 TC 24 Z9 24 U1 3 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 J9 ENVIRON INT JI Environ. Int. PD NOV PY 2009 VL 35 IS 8 BP 1160 EP 1163 DI 10.1016/j.envint.2009.07.011 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA 513YU UT WOS:000271360900008 PM 19665798 ER PT J AU English, PB Sinclair, AH Ross, Z Anderson, H Boothe, V Davis, C Ebi, K Kagey, B Malecki, K Shultz, R Simms, E AF English, Paul B. Sinclair, Amber H. Ross, Zev Anderson, Henry Boothe, Vicki Davis, Christine Ebi, Kristie Kagey, Betsy Malecki, Kristen Shultz, Rebecca Simms, Erin TI Environmental Health Indicators of Climate Change for the United States: Findings from the State Environmental Health Indicator Collaborative SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review DE adaptation; air quality; climate change; environmental health; heat; indicators; vulnerability ID RAGWEED AMBROSIA-ARTEMISIIFOLIA; HARMFUL ALGAL BLOOMS; PUBLIC-HEALTH; HEAT-WAVE; NATIONAL ASSESSMENT; TROPOSPHERIC OZONE; POTENTIAL IMPACTS; IXODES-SCAPULARIS; POLLEN PRODUCTION; WESTERN US AB OBJECTIVE: To develop public health adaptation strategies and to project the impacts of climate change on human health, indicators of vulnerability and preparedness along with accurate surveillance data on climate-sensitive health outcomes are needed. We researched and developed environmental health indicators for inputs into human health vulnerability assessments for climate change and to propose public health preventative actions. DATA SOURCES: We conducted a review of the scientific literature to identify outcomes and actions that were related to climate change. Data sources included governmental and nongovernmental agencies and the published literature. DATA EXTRACTION: Sources were identified and assessed for completeness, usability, and accuracy. Priority was then given to identifying longitudinal data sets that were applicable at the state and community level. DATA SYNTHESIS: We present a list of surveillance indicators for practitioners and policy makers that include climate-sensitive health outcomes and environmental and vulnerability indicators, as well as mitigation, adaptation, and policy indicators of climate change. CONCLUSIONS: A review of environmental health indicators for climate change shows that data exist for many of these measures, but more evaluation of their sensitivity and usefulness is needed. Further attention is necessary to increase data quality and availability and to develop new surveillance databases, especially for climate-sensitive morbidity. C1 [English, Paul B.] Calif Dept Publ Hlth, Ctr Chron Dis Prevent & Hlth Promot, Environm Hlth Invest Branch, Richmond, CA 94804 USA. [Sinclair, Amber H.] Univ Georgia, Dept Publ Adm & Policy, Augusta, GA USA. [Ross, Zev] Zev Ross Spatial Anal, Ithaca, NY USA. [Anderson, Henry; Malecki, Kristen] Wisconsin Div Publ Hlth, Madison, WI USA. [Boothe, Vicki] US Ctr Dis Control & Prevent, Coordinating Ctr Environm Hlth & Injury Prevent, Atlanta, GA USA. [Davis, Christine] US EPA, Climate Int & Multimedia Grp, Res Triangle Pk, NC 27711 USA. [Ebi, Kristie] LLC, ESS, Alexandria, VA USA. [Kagey, Betsy] Georgia Dept Human Resources, Div Publ Hlth, Atlanta, GA USA. [Shultz, Rebecca] Florida Dept Hlth, Tallahassee, FL USA. [Simms, Erin] Council State & Territorial Epidemiologists, Atlanta, GA USA. RP English, PB (reprint author), Calif Dept Publ Hlth, Ctr Chron Dis Prevent & Hlth Promot, Environm Hlth Invest Branch, 850 Marina Bay Pkwy,Bldg P,3rd Fl, Richmond, CA 94804 USA. EM penglish@dhs.ca.gov FU Council of State and Territorial Epidemiologists in Atlanta, Georgia; National Center for Environmental Health, U.S. Centers for Disease Control and Prevention FX We and the State Environmental Health Indicator Collaborative gratefully acknowledge the Council of State and Territorial Epidemiologists in Atlanta, Georgia, and the National Center for Environmental Health, U.S. Centers for Disease Control and Prevention, for supporting this work. J. Braggio and A. Houghton made helpful comments on an earlier version of the manuscript. NR 89 TC 48 Z9 48 U1 5 U2 23 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2009 VL 117 IS 11 BP 1673 EP 1681 DI 10.1289/ehp.0900708 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 514MQ UT WOS:000271399300021 PM 20049116 ER PT J AU Iqbal, S Blumenthal, W Kennedy, C Yip, FY Pickard, S Flanders, WD Loringer, K Kruger, K Caldwell, KL Brown, MJ AF Iqbal, Shahed Blumenthal, Wendy Kennedy, Chinaro Yip, Fuyuen Y. Pickard, Stephen Flanders, W. Dana Loringer, Kelly Kruger, Kirby Caldwell, Kathleen L. Brown, Mary Jean TI Hunting with lead: Association between blood lead levels and wild game consumption SO ENVIRONMENTAL RESEARCH LA English DT Article DE Lead; Lead poisoning; Child health; Environmental health; Sports; Epidemiology; Environmental exposure; Food contamination; Ecology ID 10 MU-G/DL; 1ST NATIONS; TISSUE-LEAD; EXPOSURE; SHOT; BIRDS; CHILDREN; AMMUNITION; FRAGMENTS; ONTARIO AB Background: Wild game hunting is a popular activity in many regions of the United States. Recently, the presence of lead fragments in wild game meat, presumably from the bullets or shot used for hunting, has raised concerns about health risks from meat consumption. Objective: This study examined the association between blood lead levels (PbB) and wild game consumption. Methods: We recruited 742 participants, aged 2-92 years, from six North Dakota cities. Blood lead samples were collected from 736 persons. Information on socio-demographic background, housing, lead exposure source, and types of wild game consumption (i.e., venison, other game such as moose, birds) was also collected. Generalized estimating equations (GEE) were used to determine the association between PbB and wild game consumption. Results: Most participants reported consuming wild game (80.8%) obtained from hunting (98.8%). The geometric mean PbB were 1.27 and 0.84 mu g/dl among persons who did and did not consume wild game, respectively. After adjusting for potential confounders, persons who consumed wild game had 0.30 mu g/dl (95% confidence interval: 0.16-0.44 mu g/dl) higher PbB than persons who did not. For all game types, recent (< 1 month) wild game consumption was associated with higher PbB. PbB was also higher among those who consumed a larger serving size (>= 2 oz vs. < 2 oz); however, this association was significant for 'other game' consumption only. Conclusions: Participants who consumed wild game had higher PbB than those who did not consume wild game. Careful review of butchering practices and monitoring of meat-packing processes may decrease lead exposure from wild game consumption. Published by Elsevier Inc. C1 [Iqbal, Shahed; Yip, Fuyuen Y.] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [Iqbal, Shahed; Loringer, Kelly] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Chamblee, GA 30341 USA. [Blumenthal, Wendy; Kennedy, Chinaro; Brown, Mary Jean] Ctr Dis Control & Prevent, Lead Poisoning Prevent Branch, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [Pickard, Stephen] Ctr Dis Control & Prevent, Off Sci & Publ Hlth Practice, Coordinating Off Terrorism Preparedness & Emergen, Chamblee, GA 30341 USA. [Pickard, Stephen; Kruger, Kirby] N Dakota Dept Hlth, Fargo, ND USA. [Flanders, W. Dana] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [Caldwell, Kathleen L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [Flanders, W. Dana] Emory Univ, Atlanta, GA 30322 USA. RP Iqbal, S (reprint author), Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Natl Ctr Environm Hlth, 4770 Buford Hwy NE, Chamblee, GA 30341 USA. EM SIqbal@cdc.gov FU Division of Laboratory Sciences, National Center for Environmental Health; North Dakota Department of Health FX The authors would like to acknowledge the contribution and support Charles Dodson, BS of the Division of Laboratory Sciences, National Center for Environmental Health and the North Dakota Department of Health. NR 49 TC 33 Z9 36 U1 2 U2 38 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2009 VL 109 IS 8 BP 952 EP 959 DI 10.1016/j.envres.2009.08.007 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 513BL UT WOS:000271296900002 PM 19747676 ER PT J AU Wannemuehler, KA Lyles, RH Waller, LA Hoekstra, RM Klein, M Tolbert, P AF Wannemuehler, Kathleen A. Lyles, Robert H. Waller, Lance A. Hoekstra, Robert M. Klein, Mitchel Tolbert, Paige TI A conditional expectation approach for associating ambient air pollutant exposures with health outcomes SO ENVIRONMETRICS LA English DT Article DE air pollution; conditional expectation; environmental epidemiology; maximum likelihood; measurement error; spatial variability ID EMERGENCY-DEPARTMENT VISITS; MEASUREMENT ERROR; SPATIAL INTERPOLATION; TIME-SERIES; CONSEQUENCES; VARIABLES AB Our research focuses on the association between exposure to an airborne pollutant and counts of emergency department (ED) visits attributed to a specific chronic illness. The motivating example for this analysis of measurement error in time series studies of air pollution and acute health Outcomes was a Study of ED visits from a 20-county Atlanta metropolitan statistical area from 1993 to 1999. The research presented illustrates the impact of using various surrogates for unobserved measurements of ambient concentrations at the zip code level. Simulation results indicate that the impact of measurement error on the association between pollutant exposure and a health outcome can be substantial. The proposed conditional expectation (CE) approach provided reliable estimates of the association and exhibited good confidence interval coverage for a variety of magnitudes of association. Use of a single-centrally located monitor, the arithmetic average, the nearest-neighbor monitor, and the inverse-distance weighted average surrogates resulted in biased estimates and poor coverage rates, especially for larger magnitudes of the association. A focus on obtaining reasonable exposure measurements within clearly defined subregions is important when the Pollutant exposure of interest exhibits strong spatial variability. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Wannemuehler, Kathleen A.; Hoekstra, Robert M.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. [Lyles, Robert H.; Waller, Lance A.] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA 30329 USA. [Klein, Mitchel; Tolbert, Paige] Emory Univ, Rollins Sch Publ Hlth, Dept Environm, Atlanta, GA 30329 USA. [Klein, Mitchel; Tolbert, Paige] Emory Univ, Rollins Sch Publ Hlth, Dept Occupat Hlth, Atlanta, GA 30329 USA. RP Wannemuehler, KA (reprint author), Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. EM kpw9@cdc.gov RI Tolbert, Paige/A-5676-2015 FU National Institute of Environmental Health Sciences [ES012458]; American Chemistry Council; American College of Epidemiology; National Institute for Environmental Health Sciences [R01ES11294]; U.S. Environmental Protection Agency [R82921301-0]; Electric Power Research Institute [EP-P27723/C13172] FX R.H.L. was supported in part by and R01 from the National Institute of Environmental Health Sciences (ES012458), and by an Early Career Award from the American Chemistry Council and the American College of Epidemiology. This work was also supported by grants from National Institute for Environmental Health Sciences (R01ES11294), U.S. Environmental Protection Agency (R82921301-0), and the Electric Power Research Institute (EP-P27723/C13172). We thank Kristi Metzger, James A. Mulholland, Jennifer Peel, Stefanie E. Sarnat, and Jing Yu for all their helpful input and discussions. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 33 TC 6 Z9 6 U1 0 U2 5 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1180-4009 J9 ENVIRONMETRICS JI Environmetrics PD NOV PY 2009 VL 20 IS 7 BP 877 EP 894 DI 10.1002/env.978 PG 18 WC Environmental Sciences; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Environmental Sciences & Ecology; Mathematics GA 516SZ UT WOS:000271564400005 PM 20161413 ER PT J AU Bartell, S Calafat, A Lyu, C Kato, K Ryan, PB Steenland, K AF Bartell, Scott Calafat, Antonia Lyu, Christopher Kato, Kayoko Ryan, P. Barry Steenland, Kyle TI Residents' PFOA Serum Concentrations Before and After Granular Activated Carbon Filtration at Public Water Systems in Little Hocking, Ohio and Lubeck, West Virginia SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Bartell, Scott] Univ Calif Irvine, Irvine, CA USA. [Calafat, Antonia; Kato, Kayoko] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Lyu, Christopher] Battelle Ctr Publ Hlth Res & Evaluat, Durham, NC USA. [Bartell, Scott; Ryan, P. Barry; Steenland, Kyle] Emory Univ, Atlanta, GA 30322 USA. RI Bartell, Scott/M-8919-2013 OI Bartell, Scott/0000-0001-7797-2906 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S255 EP S255 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101435 ER PT J AU Braun, J Dietrich, K Yolton, K Hornung, R Lanphear, B Calafat, A AF Braun, Joe Dietrich, Kim Yolton, Kim Hornung, Richard Lanphear, Bruce Calafat, Antonia TI Prenatal Bisphenol A Exposure and Behavioral Problems In Two Year Old Children SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Braun, Joe] Univ N Carolina, Chapel Hill, NC USA. [Dietrich, Kim; Yolton, Kim; Hornung, Richard] Cincinnati Childrens Hosp & Med Ctr, Cincinnati, OH USA. [Lanphear, Bruce] Simon Fraser Univ, Vancouver, BC, Canada. [Calafat, Antonia] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S20 EP S20 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100026 ER PT J AU Cao, Y Blount, B Valentin-Blasini, L Bernbaum, J Phillips, T Rogan, W AF Cao, Yang Blount, Ben Valentin-Blasini, Liza Bernbaum, Judy Phillips, Terry Rogan, Walter TI Pollutant Chemicals, Thyrotropin, and Thyroid Hormone in Infants SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Cao, Yang; Rogan, Walter] NIEHS, Res Triangle Pk, NC 27709 USA. [Blount, Ben; Valentin-Blasini, Liza] CDC, Atlanta, GA 30333 USA. [Bernbaum, Judy] Childrens Hosp, Philadelphia, PA 19104 USA. [Phillips, Terry] NIBIB, Bethesda, MD USA. RI Rogan, Walter/I-6034-2012 OI Rogan, Walter/0000-0002-9302-0160 NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S160 EP S161 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101130 ER PT J AU Cao, Y Chen, AM Jones, R Peddada, S Radcliffe, J Dietrich, K Caldwell, K Rogan, W AF Cao, Yang Chen, Aimin Jones, Robert Peddada, Shyamal Radcliffe, Jerilynn Dietrich, Kim Caldwell, Kathleen Rogan, Walter TI Efficacy of Succimer Chelation of Mercury at Background Exposures in Toddlers: Randomised Trial SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Cao, Yang; Peddada, Shyamal; Rogan, Walter] NIEHS, Res Triangle Pk, NC 27709 USA. [Chen, Aimin] Creighton Univ, Omaha, NE 68178 USA. [Jones, Robert; Caldwell, Kathleen] CDC, Atlanta, GA 30333 USA. [Radcliffe, Jerilynn] Childrens Hosp, Philadelphia, PA 19104 USA. [Dietrich, Kim] Univ Cincinnati, Cincinnati, OH USA. RI Jones, Robert/E-1170-2011; Peddada, Shyamal/D-1278-2012; Rogan, Walter/I-6034-2012 OI Rogan, Walter/0000-0002-9302-0160 NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S159 EP S160 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101127 ER PT J AU Chevrier, J Harley, K Bradman, A Sjodin, A Eskenazi, B AF Chevrier, Jonathan Harley, Kim Bradman, Asa Sjodin, Andreas Eskenazi, Brenda TI Associations Between Maternal PBDE Serum Concentrations and Birth Weight and Duration of Gestation SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Chevrier, Jonathan; Harley, Kim; Bradman, Asa; Eskenazi, Brenda] UC Berkeley, Berkeley, CA USA. [Sjodin, Andreas] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Sjodin, Andreas/F-2464-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S91 EP S92 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100245 ER PT J AU Darrow, L Klein, M Correa, A Flanders, WD Waller, L Marcus, M Strickland, M Tolbert, P AF Darrow, Lyndsey Klein, Mitch Correa, Adolfo Flanders, W. Dana Waller, Lance Marcus, Michele Strickland, Matthew Tolbert, Paige TI Ambient Air Pollution and Birth Weight in Full-Term Infants in Atlanta, 1994-2004 SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Darrow, Lyndsey; Klein, Mitch; Flanders, W. Dana; Waller, Lance; Strickland, Matthew; Tolbert, Paige] Emory Univ, Atlanta, GA 30322 USA. [Correa, Adolfo] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RI Tolbert, Paige/A-5676-2015; Marcus, Michele/J-2746-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S54 EP S54 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100128 ER PT J AU Engel, S Wolff, M Calafat, A Diplas, A Silva, M Lambertini, L Bausell, R Meadows, M Lee, M Sperling, R Wetmur, J Chen, J AF Engel, Stephanie Wolff, Mary Calafat, Antonia Diplas, Andreas Silva, Manori Lambertini, Luca Bausell, Rebecca Meadows, Molly Lee, Menjean Sperling, Rhoda Wetmur, James Chen, Jia TI Correlations of Urinary and Amniotic Fluid Phthalate Metabolite Concentrations and Expression of Imprinted Genes in Human Placenta SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Engel, Stephanie; Wolff, Mary; Diplas, Andreas; Lambertini, Luca; Bausell, Rebecca; Meadows, Molly; Lee, Menjean; Sperling, Rhoda; Wetmur, James; Chen, Jia] Mt Sinai Sch Med, New York, NY USA. [Calafat, Antonia; Silva, Manori] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S110 EP S111 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100308 ER PT J AU Engel, S Miodovnik, A Canfield, R Zhu, CB Calafat, A Silva, M Wolff, M AF Engel, Stephanie Miodovnik, Amir Canfield, Richard Zhu, Chenbo Calafat, Antonia Silva, Manori Wolff, Mary TI Prenatal Exposure to Low Molecular Weight Phthalates and Childhood Behavior and Executive Functioning SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Engel, Stephanie; Miodovnik, Amir; Zhu, Chenbo; Wolff, Mary] Mt Sinai Sch Med, New York, NY USA. [Calafat, Antonia; Silva, Manori] Ctr Dis Control & Prevent, Atlanta, GA USA. [Canfield, Richard] Cornell Univ, Ithaca, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S14 EP S14 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100006 ER PT J AU Eskenazi, B Marks, A Chevrier, J Harley, K Bradman, A Sjodin, A AF Eskenazi, Brenda Marks, Amy Chevrier, Jonathan Harley, Kim Bradman, Asa Sjodin, Andreas TI Associations Between Maternal PBDE Serum Concentrations and Child Neurodevelopment in the Chamacos Cohort SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Eskenazi, Brenda; Marks, Amy; Chevrier, Jonathan; Harley, Kim; Bradman, Asa] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Sjodin, Andreas] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S94 EP S95 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100255 ER PT J AU Fortenberry, GZ Meeker, JD Hu, H Calafat, A Sanchez, BN Cantonwine, DE LaMadrid-Figueroa, H Hernandez-Avila, M Tellez-Rojo, MM AF Fortenberry, G. Z. Meeker, J. D. Hu, H. Calafat, A. Sanchez, B. N. Cantonwine, D. E. LaMadrid-Figueroa, H. Hernandez-Avila, M. Tellez-Rojo, M. M. TI Preterm Birth and Bisphenol A Concentrations in Mexico City: A Pilot Study SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Fortenberry, G. Z.; Meeker, J. D.; Hu, H.; Sanchez, B. N.; Cantonwine, D. E.] Univ Michigan, Ann Arbor, MI 48109 USA. [Calafat, A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [LaMadrid-Figueroa, H.; Hernandez-Avila, M.; Tellez-Rojo, M. M.] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S174 EP S174 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101174 ER PT J AU Harari, R Julvez, J Bellinger, D Barr, D Debes, F Grandjean, P AF Harari, Raul Julvez, Jordi Bellinger, David Barr, Dana Debes, Frodi Grandjean, Philippe TI Prenatal Pesticide Exposure as Predictor of Neurobehavioural Deficits and Increased Blood Pressure at School Age: Part of a Silent Pandemic? SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Harari, Raul] Corp Desarrollo Prod & Medio Ambiente Laboral, Quito, Ecuador. [Julvez, Jordi; Bellinger, David; Grandjean, Philippe] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Barr, Dana] Ctr Dis Control & Prevent, Atlanta, GA USA. [Debes, Frodi; Grandjean, Philippe] Univ So Denmark, Odense, Denmark. RI Harari, Raul/E-1241-2015 OI Harari, Raul/0000-0002-1829-5316 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S21 EP S21 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100029 ER PT J AU Harley, K Marks, A Chevrier, J Sjodin, A Bradman, A Eskenazi, B AF Harley, Kim Marks, Amy Chevrier, Jonathan Sjodin, Andreas Bradman, Asa Eskenazi, Brenda TI Maternal PBDE Exposure and Time to Pregnancy SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Harley, Kim; Marks, Amy; Chevrier, Jonathan; Bradman, Asa; Eskenazi, Brenda] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Sjodin, Andreas] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Sjodin, Andreas/F-2464-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S90 EP S91 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100242 ER PT J AU Hernandez-Ramirez, R Galvan-Portillo, M Calafat, AM Cebrian-Garcia, ME Torres-Sanchez, L Needham, LL Romero-Franco, M Lopez-Carrillo, L AF Hernandez-Ramirez, Raul Galvan-Portillo, Marcia Calafat, Antonia M. Cebrian-Garcia, Mariano E. Torres-Sanchez, Luisa Needham, Larry L. Romero-Franco, Michelle Lopez-Carrillo, Lizbeth TI Concentrations of Urinary Phthalate Metabolites in Mexican Women with and without Diabetes SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Hernandez-Ramirez, Raul; Galvan-Portillo, Marcia; Torres-Sanchez, Luisa; Romero-Franco, Michelle; Lopez-Carrillo, Lizbeth] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico. [Calafat, Antonia M.; Needham, Larry L.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Cebrian-Garcia, Mariano E.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico. RI Needham, Larry/E-4930-2011 NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S129 EP S129 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101027 ER PT J AU Korrick, S Williams, P Sergeyev, O Lee, M Burns, J Delprato, J Revich, B Altshul, L Patterson, D Turner, W Hauser, R AF Korrick, Susan Williams, Paige Sergeyev, Oleg Lee, Mary Burns, Jane Delprato, Julie Revich, Boris Altshul, Larisa Patterson, Donald Turner, Wayman Hauser, Russ TI Dioxin Exposure and Puberty Onset Among Russian Boys SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Korrick, Susan; Hauser, Russ] Harvard Univ, Sch Med, Boston, MA USA. [Korrick, Susan; Williams, Paige; Burns, Jane; Delprato, Julie; Altshul, Larisa; Hauser, Russ] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Sergeyev, Oleg] Chapaevsk Med Assoc, Chapaevsk, Samara Region, Russia. [Lee, Mary] Univ Massachusetts, Sch Med, Worcester, MA USA. [Revich, Boris] Russian Acad Sci, Moscow, Russia. [Patterson, Donald] EnviroSolut Consulting Inc, Jasper, GA USA. [Turner, Wayman] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Sergeyev, Oleg/H-8854-2013 OI Sergeyev, Oleg/0000-0002-5745-3348 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S25 EP S25 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100041 ER PT J AU Lewis, L Redwood, Y McGeehin, M AF Lewis, Lauren Redwood, Yanique McGeehin, Michael TI Aflatoxicosis and Food Contamination: Food Monitoring in High Risk Populations SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Lewis, Lauren; Redwood, Yanique; McGeehin, Michael] CDC, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S238 EP S238 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101380 ER PT J AU Lopez-Carrillo, L Hernandez-Ramirez, R Calafat, AM Cebrian-Garcia, ME Torres-Sanchez, L Romero-Franco, M Galvan-Portillo, M Needham, LL AF Lopez-Carrillo, Lizbeth Hernandez-Ramirez, Raul U. Calafat, Antonia M. Cebrian-Garcia, Mariano E. Torres-Sanchez, Luisa Romero-Franco, Michelle Galvan-Portillo, Marcia Needham, Larry L. TI Urinary Phthalates and Breast Cancer Risk in Mexico SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Lopez-Carrillo, Lizbeth; Hernandez-Ramirez, Raul U.; Torres-Sanchez, Luisa; Romero-Franco, Michelle; Galvan-Portillo, Marcia] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico. [Calafat, Antonia M.; Needham, Larry L.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Cebrian-Garcia, Mariano E.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico. RI Needham, Larry/E-4930-2011 NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S35 EP S35 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100070 ER PT J AU Mccoy, L Schleicher, R Powers, C AF McCoy, Leslie Schleicher, Rosemary Powers, Carissa TI Enabling Comparison of Aflatoxin B1 Exposure in Different Study Populations Using Different Measurement Techniques SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [McCoy, Leslie] CDC Battelle, Atlanta, GA USA. [Schleicher, Rosemary; Powers, Carissa] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S237 EP S238 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101379 ER PT J AU Miodovnik, A Wolff, M Calafat, A Silva, M Engel, S AF Miodovnik, Amir Wolff, Mary Calafat, Antonia Silva, Manori Engel, Stephanie TI Prenatal Exposure to Low Molecular Weight Phthalates and Autistic Social Impairment SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Miodovnik, Amir; Wolff, Mary; Engel, Stephanie] Mt Sinai Sch Med, New York, NY USA. [Calafat, Antonia; Silva, Manori] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S168 EP S168 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101154 ER PT J AU Nachman, K Parker, J AF Nachman, Keeve Parker, Jennifer TI Fine Particulate Air Pollution and Asthma in Adults SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Nachman, Keeve] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Parker, Jennifer] Natl Ctr Hlth Stat, Ctr Dis Control & Prevent, Hyattsville, MD 20782 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S183 EP S183 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101202 ER PT J AU Pinney, SM Windham, GC Biro, FM Kushi, LH Yaghjyan, L Calafat, A Kato, K Succop, P Brown, MK Hernick, A Bornschein, R AF Pinney, Susan M. Windham, Gayle C. Biro, Frank M. Kushi, Larry H. Yaghjyan, Lusine Calafat, Antonia Kato, Kayoko Succop, Paul Brown, M. Kathryn Hernick, Ann Bornschein, Robert TI Perfluorooctanoic Acid (PFOA) and Pubertal Maturation in Young Girls SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Pinney, Susan M.; Yaghjyan, Lusine; Succop, Paul; Hernick, Ann; Bornschein, Robert] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Windham, Gayle C.] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA USA. [Biro, Frank M.] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA. [Biro, Frank M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. [Kushi, Larry H.] Kaiser Permanente, Div Res, Oakland, CA USA. [Calafat, Antonia; Kato, Kayoko] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. NR 0 TC 5 Z9 5 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S80 EP S80 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100209 ER PT J AU Purdue, M Engel, L Langseth, H Needham, L Andersen, A Barr, D Blair, A Rothman, N McGlynn, K AF Purdue, Mark Engel, Lawrence Langseth, Hilde Needham, Larry Andersen, Aage Barr, Dana Blair, Aaron Rothman, Nathaniel McGlynn, Katherine TI Pre-Diagnostic Serum Concentrations of Organochlorine Compounds and Risk of Testicular Germ Cell Tumors SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Purdue, Mark; Blair, Aaron; Rothman, Nathaniel; McGlynn, Katherine] NCI, Bethesda, MD 20892 USA. [Engel, Lawrence] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Langseth, Hilde; Andersen, Aage] Norwegian Canc Registry, Oslo, Norway. [Needham, Larry; Barr, Dana] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Needham, Larry/E-4930-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S243 EP S243 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101396 ER PT J AU Romero-Franco, M Hernandez-Ramirez, RU Calafat, AM Cebrian-Garcia, ME Galvan-Portillo, M Torres-Sanchez, L Needham, LL Wolff, MS Lopez-Carrillo, L AF Romero-Franco, Michelle Hernandez-Ramirez, Raul U. Calafat, Antonia M. Cebrian-Garcia, Mariano E. Galvan-Portillo, Marcia Torres-Sanchez, Luisa Needham, Larry L. Wolff, Mary S. Lopez-Carrillo, Lizbeth TI Personal Care Products' Use and Its Association with Urine Concentrations of Phthalate Metabolites SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Romero-Franco, Michelle; Hernandez-Ramirez, Raul U.; Torres-Sanchez, Luisa; Lopez-Carrillo, Lizbeth] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico. [Calafat, Antonia M.; Needham, Larry L.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Cebrian-Garcia, Mariano E.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico. [Wolff, Mary S.] Mt Sinai Sch Med, Ctr Childrens Environm Hlth & Dis Prevent Dis, New York, NY USA. RI Needham, Larry/E-4930-2011 NR 0 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S36 EP S36 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100074 ER PT J AU Rundle, A Whyatt, R Camann, D Hoepner, L Holmes, D Calafat, A Perera, F AF Rundle, Andrew Whyatt, Robin Camann, David Hoepner, Lori Holmes, Darrell Calafat, Antonia Perera, Frederica TI Prenatal Exposures to Phthalates and Polycyclic Aromatic Hydrocarbons and Body Size at Age Five SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Rundle, Andrew; Whyatt, Robin; Hoepner, Lori; Holmes, Darrell; Perera, Frederica] Mailman Sch Publ Hlth, New York, NY USA. [Camann, David] SW Res Inst, San Antonio, TX USA. [Calafat, Antonia] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S258 EP S259 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101446 ER PT J AU Slama, R Woodruff, T Lepeule, J Parker, JD AF Slama, Remy Woodruff, Tracey Lepeule, Johanna Parker, Jennifer D. TI An Overview of Recent Publications and Current Issues on Air Pollution and Pregnancy Outcomes SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Slama, Remy; Lepeule, Johanna] INSERM, F-94275 Le Kremlin Bicetre, France. [Woodruff, Tracey] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Parker, Jennifer D.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. RI lepeule, johanna/N-2579-2013; LEPEULE, Johanna/K-1085-2016; Slama, Remy/M-1755-2013 OI Slama, Remy/0000-0002-8980-8529 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S259 EP S259 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101449 ER PT J AU Stein, C Chen, J Diplas, A Lambertini, L Calafat, A Ye, XY Teitelbaum, S Wetmur, J Wolff, M Sperling, R Lee, M Engel, S AF Stein, Cheryl Chen, Jia Diplas, Andreas Lambertini, Luca Calafat, Antonia Ye, Xiaoyun Teitelbaum, Susan Wetmur, James Wolff, Mary Sperling, Rhoda Lee, Menjean Engel, Stephane TI Prenatal Phenol Exposure and Expression of Imprinted Genes in Human Placenta SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Stein, Cheryl; Chen, Jia; Diplas, Andreas; Lambertini, Luca; Teitelbaum, Susan; Wetmur, James; Wolff, Mary; Sperling, Rhoda; Lee, Menjean; Engel, Stephane] Mt Sinai Sch Med, New York, NY USA. [Calafat, Antonia; Ye, Xiaoyun] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S107 EP S107 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100297 ER PT J AU Tertelbaum, S Wolff, M Hanptman, M Galvez, M Brenner, B Ye, XY Silva, M Calatat, A AF Tertelbaum, Susan Wolff, Mary Hanptman, Marissa Galvez, Maida Brenner, Barbara Ye, Xiaoyun Silva, Manori Calatat, Antonia TI Personal Care Product Use and Endocrine Disrupting Chemicals in Urban Minority Children SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Tertelbaum, Susan; Wolff, Mary; Hanptman, Marissa; Galvez, Maida; Brenner, Barbara] Mt Sinai Sch Med, New York, NY USA. [Ye, Xiaoyun; Silva, Manori; Calatat, Antonia] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S20 EP S20 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100025 ER PT J AU Warner, M Eskenazi, B Harley, K Bradman, A Aguilar, R Barr, D AF Warner, M. Eskenazi, B. Harley, K. Bradman, A. Aguilar, R. Barr, D. TI In Utero Organochlorine Exposure and Obesity in Children of Farmworkers SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Warner, M.; Eskenazi, B.; Harley, K.; Bradman, A.; Aguilar, R.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Barr, D.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S243 EP S244 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101398 ER PT J AU Wells, EM Verdon, CP Jarrett, J Caldwell, KL Witter, F Navas-Acien, A Goldman, LR AF Wells, Ellen M. Verdon, Carl P. Jarrett, Jeff Caldwell, Kathleen L. Witter, Frank Navas-Acien, Ana Goldman, Lynn R. TI The Importance of Mercury Speciation in the Association of Mercury Exposure During Pregnancy with Elevated Maternal Blood Pressure SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Wells, Ellen M.; Navas-Acien, Ana; Goldman, Lynn R.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Verdon, Carl P.; Jarrett, Jeff; Caldwell, Kathleen L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Witter, Frank] Johns Hopkins Sch Med, Baltimore, MD USA. RI Goldman, Lynn/D-5372-2012 NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S220 EP S220 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101320 ER PT J AU Wells, EM Jarrett, J Verdon, CP Caldwell, KL Navas-Acien, A Witter, F Goldman, LR AF Wells, Ellen M. Jarrett, Jeff Verdon, Carl P. Caldwell, Kathleen L. Navas-Acien, Ana Witter, Frank Goldman, Lynn R. TI A Dynamic Relationship Between Methyl Mercury, Inorganic Mercury, and Total Mercury in Umbilical Cord Blood SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Wells, Ellen M.; Navas-Acien, Ana; Goldman, Lynn R.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Jarrett, Jeff; Verdon, Carl P.; Caldwell, Kathleen L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Witter, Frank] Johns Hopkins Sch Med, Baltimore, MD USA. RI Goldman, Lynn/D-5372-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S89 EP S89 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100238 ER PT J AU Williams, M Barr, D Camann, D Rundle, A Rauh, V Whyatt, R AF Williams, Megan Barr, Dana Camann, David Rundle, Andrew Rauh, Virginia Whyatt, Robin TI Prenatal Exposure to Pyrethroid Insecticides and Infant Neurocognitive Development at 3 Years of Age SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Williams, Megan; Rundle, Andrew; Rauh, Virginia; Whyatt, Robin] Columbia Ctr Childrens Environm Hlth, New York, NY USA. [Barr, Dana] Ctr Dis Control & Prevent, Atlanta, GA USA. [Camann, David] SW Res Inst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S222 EP S223 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874101329 ER PT J AU Windham, GC Pinney, SM Lum, R Sjodin, A Kushi, LH Biro, FM Needham, L Hiatt, R AF Windham, Gayle C. Pinney, Susan M. Lum, Raymond Sjodin, Andreas Kushi, Lawrence H. Biro, Frank M. Needham, Larry Hiatt, Robert TI Serum Biomarkers of Potential Hormonally Active Chemicals and Age at Pubertal Transition in Girls SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Windham, Gayle C.] Calif Dept Publ Hlth, Richmond, CA USA. [Pinney, Susan M.; Biro, Frank M.] Univ Cincinnati, Coll Med, Cincinnati, OH USA. [Lum, Raymond] Impact Assessment Inc, La Jolla, CA USA. [Sjodin, Andreas; Needham, Larry] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kushi, Lawrence H.] Kaiser Permanente, Div Res, Oakland, CA USA. [Hiatt, Robert] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA. RI Needham, Larry/E-4930-2011; Sjodin, Andreas/F-2464-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S87 EP S87 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100231 ER PT J AU Wolff, MS Teitelbaum, S Praney, S Windham, G Kushi, LH Biro, F Erdinann, C Hiatt, R Silva, MJ Ye, XY Rybak, ME Pfeiffer, CM Liao, L Calafat, AM AF Wolff, Mary S. Teitelbaum, Susan Praney, Susan Windham, Gayle Kushi, Lawrence H. Biro, Frank Erdinann, Chris Hiatt, Robert Silva, Manori J. Ye, Xiaoyun Rybak, Michael E. Pfeiffer, Christine M. Liao, Laura Calafat, Antonia M. TI Joint Effects of BMI, Diet, and Urinary Biomarkers of Environmental Exposures in Relation to Female Pubertal Maturation SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 21st Annual Conference of the International-Society-for-Environmental-Epidemiology CY AUG 25-29, 2009 CL Dublin, IRELAND C1 [Wolff, Mary S.; Teitelbaum, Susan; Liao, Laura] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA. [Praney, Susan; Calafat, Antonia M.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH USA. [Windham, Gayle] Calif State Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA USA. [Kushi, Lawrence H.] Kaiser Permanente, Div Res, Oakland, CA USA. [Biro, Frank] Cincinnati Childrens Hosp Med Ctr, Div Adolescent Med, Cincinnati, OH USA. Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA. [Hiatt, Robert] UCSF, Dept Epidemiol & Biostat, San Francisco, CA USA. [Silva, Manori J.; Ye, Xiaoyun; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2009 VL 20 IS 6 SU S BP S44 EP S44 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507SE UT WOS:000270874100098 ER PT J AU Durr, S Mindekem, R Kaninga, Y Moto, DD Meltzer, MI Vounatsou, P Zinsstag, J AF Durr, S. Mindekem, R. Kaninga, Y. Moto, D. Doumagoum Meltzer, M. I. Vounatsou, P. Zinsstag, J. TI Effectiveness of dog rabies vaccination programmes: comparison of owner-charged and free vaccination campaigns SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Canine rabies; Chad; owner charge; public good; vaccination ID CANINE RABIES; CHAD; COVERAGE; NDJAMENA; AFRICA AB We investigated the percentage of dogs that could be vaccinated against rabies by conducting a pilot campaign in N'Djamena, Chad. Owners were charged US$4.13 per dog vaccinated, and 24% of all dogs in the three city districts covered by the campaign were vaccinated. Total campaign costs were US$7623, resulting in an average of US$19.40 per vaccinated dog. This is five times more expensive than the cost per animal vaccinated during a previous free vaccination campaign for dog-owners, conducted in the same districts. The free campaign, which vaccinated 2605 more dogs than this campaign, cost an additional US$1.45 per extra dog vaccinated. Campaigns in which owners are charged for vaccinations result in lower vaccination rates than in free campaigns. Public health officials can use these results when evaluating the costs and benefits of subsidizing dog rabies vaccination programmes. C1 [Durr, S.; Vounatsou, P.; Zinsstag, J.] Swiss Trop Inst, CH-4002 Basel, Switzerland. [Mindekem, R.; Moto, D. Doumagoum] Ctr Support Sante Int, Ndjamena, Chad. [Kaninga, Y.] Clin Vet Urbaine, Ndjamena, Chad. [Meltzer, M. I.] Ctr Dis Control & Prevent, Div Emerging Infect & Surveillance Syst, Atlanta, GA USA. RP Zinsstag, J (reprint author), Swiss Trop Inst, POB, CH-4002 Basel, Switzerland. EM jakob.zinsstag@unibas.ch RI Zinsstag, Jakob/A-8317-2008; Durr, Salome/C-1343-2014 OI Zinsstag, Jakob/0000-0002-8899-6097; Durr, Salome/0000-0002-7321-5980 FU Swiss Federal Veterinary Office; Wolfermann-Nageli Foundation; Commission for Research Partnership with Developing Countries; Emilia Guggenheim-Schnurr Foundation; Swiss National Centre of Competence in Research (NCCR) North-South FX We thank all international institutions, collaborators and campaign workers who contributed to this study and ensured its success through teamwork. We also thank the reviewers for their constructive comments that improved the manuscript. We thank the study sponsors: The Swiss Federal Veterinary Office, the Wolfermann-Nageli Foundation, the Commission for Research Partnership with Developing Countries and the Emilia Guggenheim-Schnurr Foundation. We acknowledge the Swiss National Centre of Competence in Research (NCCR) North-South for co-funding the study supervisor (J.Z.). Merial donated the doses of canine antirabies vaccine, for which we are grateful. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 24 TC 26 Z9 26 U1 0 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD NOV PY 2009 VL 137 IS 11 BP 1558 EP 1567 DI 10.1017/S0950268809002386 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 505BB UT WOS:000270661800005 PM 19327197 ER PT J AU Boehmer, TK Alden, NB Ghosh, TS Vogt, RL AF Boehmer, T. K. Alden, N. B. Ghosh, T. S. Vogt, R. L. TI Cryptosporidiosis from a community swimming pool: outbreak investigation and follow-up study SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Community outbreaks; Cryptosporidium; disinfection; epidemiology; water-borne infections ID RECREATIONAL WATER; MASSIVE OUTBREAK; PARVUM; NITAZOXANIDE; INFECTION; MILWAUKEE; DIARRHEA; STATES; UV AB Tri-County Health Department investigated an outbreak of cryptosporidiosis linked to a community swimming pool. A cohort study was conducted in 37 persons who were invited to the pool party; 12 (57 %) of 21 attendees had primary cryptosporidiosis infection. Risk factors for illness included swimming, getting water in mouth, and swallowing water. The pool met chlorination guidelines and used UN light irradiation, a supplemental disinfection technology that inactivates Cryptosporidium. A follow-up survey of the cohort was completed 7-8 weeks after the pool party; four (25 %) of 16 non-attendees had secondary cryptosporidiosis infection. The median duration of illness, including patients with recurring symptoms, was 26 days. Clinical response rate to nitazoxanide, a therapeutic agent, was 67 %. This study is unique because it describes a cryptosporidiosis outbreak from a well-maintained community swimming pool using supplemental disinfection. It also reports information on disease burden and treatment response. C1 [Boehmer, T. K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30341 USA. [Boehmer, T. K.; Alden, N. B.; Ghosh, T. S.; Vogt, R. L.] Tricty Hlth Dept, Greenwood Village, CO USA. RP Boehmer, TK (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, 4770 Buford Hwy NE,MS F-58, Atlanta, GA 30341 USA. EM tboehmer@cdc.gov NR 17 TC 7 Z9 7 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD NOV PY 2009 VL 137 IS 11 BP 1651 EP 1654 DI 10.1017/S0950268809002696 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 505BB UT WOS:000270661800017 PM 19426570 ER PT J AU Eberly, LE Leppik, IE Harms, SL Thurman, D Virnig, B Tuite, P McCarten, JR Caplan, L Svendsen, K Li, S Garrard, J AF Eberly, Lynn E. Leppik, I. E. Harms, S. L. Thurman, D. Virnig, B. Tuite, P. McCarten, J. R. Caplan, L. Svendsen, K. Li, S. Garrard, J. TI PREVALENCE AND FUNCTIONAL BURDEN OF EPILEPSY IN NURSING HOME ELDERLY SO EPILEPSIA LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Epilepsy-Society CY DEC 04-08, 2009 CL Boston, MA SP Amer Epilepsy Soc C1 [Eberly, Lynn E.; Leppik, I. E.; Harms, S. L.; Virnig, B.; Tuite, P.; McCarten, J. R.; Svendsen, K.; Li, S.; Garrard, J.] Univ Minnesota, Minneapolis, MN USA. [Thurman, D.] Ctr Dis Control, Atlanta, GA 30333 USA. [McCarten, J. R.] VA Med Ctr, Ctr Geriatr Res Educ & Clin, Minneapolis, MN USA. [Caplan, L.] Harvard Univ, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD NOV PY 2009 VL 50 BP 42 EP 42 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 503PP UT WOS:000270550500080 ER PT J AU Kobau, R Keane, A Eatough, N AF Kobau, Rosemarie Keane, A. Eatough, N. TI SEIZE YOUR STRENGTHS: A WORKSHOP TO PROMOTE POSITIVE FUNCTIONING IN PEOPLE WITH EPILEPSY SO EPILEPSIA LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Epilepsy-Society CY DEC 04-08, 2009 CL Boston, MA SP Amer Epilepsy Soc C1 [Kobau, Rosemarie] Ctr Dis Control & Prevent, Epilepsy Program, Atlanta, GA USA. [Kobau, Rosemarie; Keane, A.; Eatough, N.] Univ Penn, Posit Psychol Program, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD NOV PY 2009 VL 50 BP 157 EP 157 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 503PP UT WOS:000270550500331 ER PT J AU Snead, C Akenack, JA Takougang, I Niamnshi, A Tsang, V Noh, J Wilkins, P Fongwa, M Keystone, J Cockburn, L Stephens, D Angwafor, S Weiss, S Smith, M Elliott, I AF Snead, Carter Akenack, J. A. Takougang, I. Niamnshi, A. Tsang, V. Noh, J. Wilkins, P. Fongwa, M. Keystone, J. Cockburn, L. Stephens, D. Angwafor, S. Weiss, S. Smith, M. Elliott, I. TI EPILEPSY AND NEUROCYSTICERCOSIS IN NORTHWEST CAMEROON: A SEROLOGICAL STUDY SO EPILEPSIA LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Epilepsy-Society CY DEC 04-08, 2009 CL Boston, MA SP Amer Epilepsy Soc C1 [Snead, Carter; Stephens, D.; Weiss, S.; Smith, M.; Elliott, I.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Snead, Carter; Keystone, J.; Cockburn, L.; Weiss, S.] Univ Toronto, Toronto, ON, Canada. [Akenack, J. A.] Assoc Orphans & Disabled, Teze, Cameroon. [Takougang, I.; Niamnshi, A.; Angwafor, S.] Univ Yaounde, Yaounde, Cameroon. [Tsang, V.; Noh, J.; Wilkins, P.] Ctr Dis Control, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Fongwa, M.] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. [Keystone, J.] Toronto Gen Hosp, Ctr Travel & Trop Med, Toronto, ON, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD NOV PY 2009 VL 50 BP 412 EP 413 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 503PP UT WOS:000270550500925 ER PT J AU Chen, F Li, SQ Castranova, V AF Chen, Fei Li, Shengqiao Castranova, Vince TI Overlapping signature genes between hepatocellular carcinoma and intrahepatic cholangiocarcinoma SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Letter C1 [Chen, Fei; Li, Shengqiao; Castranova, Vince] NIOSH, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Chen, F (reprint author), NIOSH, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. EM LFD3@cdc.gov NR 5 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0954-691X J9 EUR J GASTROEN HEPAT JI Eur. J. Gastroenterol. Hepatol. PD NOV PY 2009 VL 21 IS 11 BP 1320 EP 1321 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 513CX UT WOS:000271301100015 PM 19826380 ER PT J AU Patel, MM Haber, P Baggs, J Zuber, P Bines, JE Parashar, UD AF Patel, Manish M. Haber, Penina Baggs, James Zuber, Patrick Bines, Julie E. Parashar, Umesh D. TI Intussusception and rotavirus vaccination: a review of the available evidence SO EXPERT REVIEW OF VACCINES LA English DT Review DE diarrhea; immunization; intussusception; rotavirus; rotavirus vaccine; safety ID RHESUS ROTAVIRUS; INFANTS; CHILDREN; EFFICACY; VACCINES; SAFETY; AGE; HOSPITALIZATION; RISK; GASTROENTERITIS AB Two live oral rotavirus vaccines (RotaTeq (R) and Rotarix (R)) have recently been recommended by the WHO for inclusion into the national immunization programs of countries worldwide. Owing to the association of the withdrawn Rotashield (R) vaccine with intussusception, these two new rotavirus vaccines underwent large clinical trials of over 60,000 infants each to assess safety with regard to this medical condition. For these two new vaccines, clinical trials and available postmarketing safety monitoring data do not indicate a risk of intussusception after vaccination, although a low-level risk cannot be excluded at present. We review these safety data for the new vaccines and for Rotashield to provide background information relevant for considering age recommendations for rotavirus vaccination. C1 [Patel, Manish M.] Ctr Dis Control & Prevent, Viral Gastroenteritis Sect, Atlanta, GA 30333 USA. [Haber, Penina; Baggs, James] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Immunizat Safety Off, Atlanta, GA USA. [Zuber, Patrick] WHO, CH-1211 Geneva, Switzerland. [Bines, Julie E.] Univ Melbourne, Royal Childrens Hosp, Murdoch Childrens Res Inst, Dept Paediat, Melbourne, Vic, Australia. [Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Patel, MM (reprint author), Ctr Dis Control & Prevent, Viral Gastroenteritis Sect, MS-A47,1600 Clifton Rd, Atlanta, GA 30333 USA. EM aul3@cdc.gov OI Baggs, James/0000-0003-0757-4683 NR 40 TC 39 Z9 40 U1 0 U2 1 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD NOV PY 2009 VL 8 IS 11 BP 1555 EP 1564 DI 10.1586/ERV.09.106 PG 10 WC Immunology SC Immunology GA 516BA UT WOS:000271515500016 PM 19863248 ER PT J AU Lanier, WA Leeper, MM Smith, KE Tillman, GE Holt, KG Gerner-Smidt, P AF Lanier, William A. Leeper, Molly M. Smith, Kirk E. Tillman, Glenn E. Holt, Kristin G. Gerner-Smidt, Peter TI Pulsed-Field Gel Electrophoresis Subtypes of Shiga Toxin-Producing Escherichia coli O157 Isolated from Ground Beef and Humans, United States, 2001-2006 SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID INSPECTION SERVICE; FOODNET SITES; RISK-FACTORS; DAIRY FARMS; INFECTION; CATTLE; EPIDEMIOLOGY; SURVEILLANCE; MINNESOTA; OUTBREAKS AB Pulsed-field gel electrophoresis XbaI patterns of Shiga toxin-producing Escherichia coli O157 (STEC O157) isolates (n = 156) found in ground beef sampled from U. S. processing plants and retail stores during 2001 to 2006 were summarized and compared with XbaI patterns from human STEC O157 isolates (n = 14,591) in the national PulseNet E. coli database. Four ground beef samples contained more than one pulsed-field gel electrophoresis subtype of STEC O157. Of the 117 unique patterns found in ground beef, 100 (85%) appeared only once, and 17 (15%) were found in more than one isolate. The six patterns that appeared most frequently in human isolates were also found among the eight most common ground beef patterns. The yearly proportion of human isolates with the two most common patterns changed inversely, such that these patterns traded dominance over the study period. Human isolates with patterns that were first detected in both ground beef and humans contemporaneously were clustered in a 6-month window around the time of the respective ground beef sample. Of the 156 ground beef isolates, 82 (53%) were indistinguishable from at least one human isolate in this 6-month window. The yearly proportions of human STEC O157 isolates that were indistinguishable from ground beef isolates decreased significantly from 2002 to 2003 (12.3-0.8%), and then increased significantly from 2003 to 2006 (overall 0.8-12.6%). This increase in the numbers of human isolates that matched a ground beef isolate occurred during a period of relatively consistent rates of ground beef contamination with STEC O157. Pattern similarity of STEC O157 isolates derived from ground beef and clinical cases may serve as a good predictor of human incidence trends. C1 [Holt, Kristin G.] Ctr Dis Control & Prevent, Food Safety & Inspect Serv, Off Publ Hlth Sci, USDA, Atlanta, GA 30333 USA. [Lanier, William A.] Food Safety & Inspect Serv, Off Field Operat, USDA, Canby, OR USA. [Lanier, William A.] Publ Hlth Serv, US Dept HHS, Rockville, MD USA. [Leeper, Molly M.; Gerner-Smidt, Peter] Ctr Dis Control & Prevent, Enter Dis Lab Branch, US Dept HHS, Atlanta, GA 30333 USA. [Smith, Kirk E.] Minnesota Dept Hlth, Acute Dis Invest & Control Sect, St Paul, MN USA. [Tillman, Glenn E.] Food Safety & Inspect Serv, Off Publ Hlth Sci, USDA, Athens, GA USA. RP Holt, KG (reprint author), Ctr Dis Control & Prevent, Food Safety & Inspect Serv, Off Publ Hlth Sci, USDA, 1600 Clifton Rd,Mailstop G24, Atlanta, GA 30333 USA. EM kristin.holt@fsis.usda.gov FU FSIS Headquarters FX The authors wish to thank the CDC PulseNet database administration team for their help with data collection. We are thankful to Sean Altekruse, Bonnie Buntain, Barbara Masters, and David Goldman at FSIS Headquarters for their support during study development. We express appreciation to Frederick Angulo at the CDC for his research guidance. We are grateful to William Cray, Neelam Narang, Priscilla Levine, Joseph Hill, and the rest of the staff at the FSIS Office of Public Health Science for their help in data confirmation and collection, and final review. The authors also thank David Determan of the Minnesota Department of Health for technical support. NR 40 TC 4 Z9 4 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD NOV PY 2009 VL 6 IS 9 BP 1075 EP 1082 DI 10.1089/fpd.2009.0269 PG 8 WC Food Science & Technology SC Food Science & Technology GA 515DL UT WOS:000271446900005 PM 19630512 ER PT J AU Goddard, KAB Ziegler, A Wellek, S AF Goddard, Katrina A. B. Ziegler, Andreas Wellek, Stefan TI Adapting the Logical Basis of Tests for Hardy-Weinberg Equilibrium to the Real Needs of Association Studies in Human and Medical Genetics SO GENETIC EPIDEMIOLOGY LA English DT Article DE equivalence test; genome-wide association study; goodness-of-fit test; population stratification; genotyping error; one-sided test ID POPULATION STRATIFICATION; GENOTYPE DISTRIBUTIONS; HUMAN GENOME; DISEQUILIBRIUM; LOCUS AB The standard procedure to assess genetic equilibrium is a chi(2) test of goodness-of-fit. As is the case with any statistical procedure of that type, the null hypothesis is that the distribution underlying the data is in agreement with the model. Thus, a significant result indicates incompatibility of the observed data with the model, which is clearly at variance with the aim in the majority of applications: to exclude the existence of gross violations of the equilibrium condition. In current practice, we try to avoid this basic logical difficulty by increasing the significance bound to the P-value (e.g. from 5 to 10%) and inferring compatibility of the data with Hardy Weinberg Equilibrium (HWE) from an insignificant result. Unfortunately, such direct inversion of a statistical testing procedure fails to produce a valid test of the hypothesis of interest, namely, that the data are in sufficiently good agreement with the model under which the P-value is calculated. We present a logically unflawed solution to the problem of establishing (approximate) compatibility of an observed genotype distribution with HWE. The test is available in one- and two-sided versions. For both versions, we provide tools for exact power calculation. We demonstrate the merits of the new approach through comparison with the traditional chi(2) goodness-of-fit test in 2 x 60 genotype distributions from 43 published genetic studies of complex diseases where departure from HWE was noted in either the case or control sample. In addition, we show that the new test is useful for the analysis of genome-wide association studies. Genet. Epidemiol. 33:569-580, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Goddard, Katrina A. B.] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA. [Goddard, Katrina A. B.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Ziegler, Andreas] Univ Lubeck, Inst Med Biometry & Stat, Lubeck, Germany. [Wellek, Stefan] Univ Heidelberg, Dept Biostat, CIMH Mannheim, D-6900 Heidelberg, Germany. RP Goddard, KAB (reprint author), Kaiser Permanente NW, Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA. EM Katrina.ab.goddard@kpchr.org OI Ziegler, Andreas/0000-0002-8386-5397 FU Medical Research Council [G0000934] FX We are grateful to Anika Gotz and Friedrich Pahlke for their support in analyzing the real data examples. We acknowledge access to the aggregated genotype calls from the 58BC. Collection of information and biological samples from the 58BC has been funded by the Medical Research Council (G0000934). We also thank Affymetrix for making available the Genome-Wide Human SNP 6.0 Array data of the HapMap samples. NR 27 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0741-0395 J9 GENET EPIDEMIOL JI Genet. Epidemiol. PD NOV PY 2009 VL 33 IS 7 BP 569 EP 580 DI 10.1002/gepi.20409 PG 12 WC Genetics & Heredity; Mathematical & Computational Biology SC Genetics & Heredity; Mathematical & Computational Biology GA 514PB UT WOS:000271406100002 PM 19235187 ER PT J AU Little, J Higgins, JPT Ioannidis, JPA Moher, D Gagnon, F von Elm, E Khoury, MJ Cohen, B Davey-Smith, G Grimshaw, J Scheet, P Gwinn, M Williamson, RE Zou, GY Hutchings, K Johnson, CY Tait, V Wiens, M Golding, J van Duijn, C McLaughlin, J Paterson, A Wells, G Fortier, I Freedman, M Zecevic, M King, R Infante-Rivard, C Stewart, A Birkett, N AF Little, Julian Higgins, Julian P. T. Ioannidis, John P. A. Moher, David Gagnon, France von Elm, Erik Khoury, Muin J. Cohen, Barbara Davey-Smith, George Grimshaw, Jeremy Scheet, Paul Gwinn, Marta Williamson, Robin E. Zou, Guang Yong Hutchings, Kim Johnson, Candice Y. Tait, Valerie Wiens, Miriam Golding, Jean van Duijn, Cornelia McLaughlin, John Paterson, Andrew Wells, George Fortier, Isabel Freedman, Matthew Zecevic, Maja King, Richard Infante-Rivard, Claire Stewart, Alex Birkett, Nick TI STrengthening the REporting of Genetic Association Studies (STREGA)-An Extension of the STROBE Statement SO GENETIC EPIDEMIOLOGY LA English DT Review DE gene-disease associations; genetics; gene-environment interaction; systematic review; meta-analysis; reporting recommendations; epidemiology; genome-wide association ID GENOME-WIDE ASSOCIATION; HARDY-WEINBERG EQUILIBRIUM; SINGLE-NUCLEOTIDE POLYMORPHISMS; POPULATION STRATIFICATION; RANDOMIZED-TRIALS; DISEASE ASSOCIATIONS; GENOTYPING ERRORS; COMPLEX DISEASES; PROSTATE-CANCER; LINKAGE-DISEQUILIBRIUM AB Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. Genet. Epidemiol. 33:581-598, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Little, Julian; Moher, David; Hutchings, Kim; Johnson, Candice Y.; Tait, Valerie; Wiens, Miriam; Birkett, Nick] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada. [Higgins, Julian P. T.] MRC, Biostat Unit, Cambridge CB2 2BW, England. [Ioannidis, John P. A.] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece. [Ioannidis, John P. A.] Tufts Univ, Sch Med, Ctr Genet Epidemiol & Modeling, Boston, MA 02111 USA. [Gagnon, France] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [von Elm, Erik] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland. [von Elm, Erik] Univ Med Ctr, Dept Med Biometry & Med Informat, German Cochrane Ctr, Freiburg, Germany. [Khoury, Muin J.; Gwinn, Marta] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA USA. [Cohen, Barbara] Publ Lib Sci, San Francisco, CA USA. [Davey-Smith, George] Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Dept Social Med, Bristol, Avon, England. [Grimshaw, Jeremy] Univ Ottawa, Ottawa Hlth Res Inst, Clin Epidemiol Program, Dept Med, Ottawa, ON K1H 8M5, Canada. [Scheet, Paul] Univ Texas Houston, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Zou, Guang Yong] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada. [Zou, Guang Yong] Robarts Res Inst, London, ON N6A 5C1, Canada. [McLaughlin, John] Canc Care Ontario, Toronto, ON, Canada. [McLaughlin, John] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Prosserman Ctr Hlth Res, Toronto, ON M5G 1X5, Canada. [Paterson, Andrew] Hosp Sick Children, Toronto, ON, Canada. [Wells, George] Univ Ottawa, Cardiovasc Res Methods Ctr, Inst Heart, Ottawa, ON K1H 8M5, Canada. [Fortier, Isabel] McGill Univ, Genome Quebec & P3G Observ, Montreal, PQ, Canada. [Fortier, Isabel] Genome Quebec Innovat Ctr, Montreal, PQ, Canada. [Freedman, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA. [Infante-Rivard, Claire] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Fac Med, Montreal, PQ, Canada. RP Little, J (reprint author), Univ Ottawa, Dept Epidemiol & Community Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada. EM jlittle@uottawa.ca RI Ioannidis, John/G-9836-2011; Higgins, Julian/H-4008-2011; Stewart, Alexandre/A-5677-2011; Grimshaw, Jeremy/D-8726-2013; McLaughlin, John/E-4577-2013; Zou, Guangyong/K-6408-2013; Paterson, Andrew/A-4088-2011; OI Golding, Jean/0000-0003-2826-3307; Higgins, Julian/0000-0002-8323-2514; Paterson, Andrew/0000-0002-9169-118X; von Elm, Erik/0000-0002-7412-0406; Stewart, Alexandre/0000-0003-2673-9164; Grimshaw, Jeremy/0000-0001-8015-8243; Moher , David /0000-0003-2434-4206 FU Canadian Institutes of Health Research NR 154 TC 45 Z9 48 U1 3 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0741-0395 J9 GENET EPIDEMIOL JI Genet. Epidemiol. PD NOV PY 2009 VL 33 IS 7 BP 581 EP 598 DI 10.1002/gepi.20410 PG 18 WC Genetics & Heredity; Mathematical & Computational Biology SC Genetics & Heredity; Mathematical & Computational Biology GA 514PB UT WOS:000271406100003 PM 19278015 ER PT J AU Bellcross, CA Lemke, AA Pape, LS Tess, AL Meisner, LT AF Bellcross, Cecelia A. Lemke, Amy A. Pape, Laura S. Tess, Angela L. Meisner, Lorraine T. TI Evaluation of a breast/ovarian cancer genetics referral screening tool in a mammography population SO GENETICS IN MEDICINE LA English DT Article DE cancer genetics; genetic screening; hereditary neoplastic syndromes; breast cancer; ovarian cancer ID BRCA2 MUTATION CARRIERS; REDUCING SALPINGO-OOPHORECTOMY; HEREDITARY BREAST-CANCER; OVARIAN-CANCER; FAMILY-HISTORY; HIGH-RISK; SUSCEPTIBILITY GENES; OPTIMAL SELECTION; BOADICEA MODEL; WOMEN AB Purpose: Simple screening tools are needed to facilitate the appropriate referral of patients for genetic counseling and testing for BRCA1/2 mutations. This study evaluated the reliability and accuracy of a "referral screening tool" designed for rapid identification of individuals at potential hereditary risk for breast/ovarian cancer. Methods: The referral screening tool was administered to 2464 unselected women undergoing screening mammography. Detailed four-generation cancer pedigrees were collected by telephone interview on a random subset of 296 women. The pedigrees were analyzed using four established hereditary risk models (BRCAPRO, Myriad II, BOADICEA, FHAT), with a >= 10% BRCA1/2 mutation probability or a FHAT score of >= 10 as the definition of "high risk." Results: The referral screening tool identified 6.2% of subjects as screen "positive" (high risk). Concordance of randomly repeated referral screening tools (156 of 2464) was 96% (kappa = 0.75). In comparison with the pedigree analyses, the referral screening tool demonstrated all overall (high risk by any model) sensitivity of 81.2%, specificity of 91.9%, and discriminatory accuracy of 0.87. Conclusions: Within the population Studied, the referral screening tool seems to be a reliable and valid tool to identify individuals who should be referred for consideration of BRCA1/2 testing. Further examination of the referral screening tool in primary care settings is warranted to assess its impact on the efficiency with which health care providers triage patients to cancer genetics services. Genet Med 2009: 11(11):783-789. C1 [Bellcross, Cecelia A.] Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI USA. [Lemke, Amy A.] Northwestern Univ, Ctr Genet Med, Chicago, IL 60611 USA. [Pape, Laura S.] Froedtert & Community Hlth, Milwaukee, WI USA. [Tess, Angela L.] St Vincents Hosp, Green Bay, WI USA. [Meisner, Lorraine T.] Cell Line Genet, Madison, WI USA. RP Bellcross, CA (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, 1600 Clifton Rd NE,MS E-61, Atlanta, GA 30333 USA. EM cbellcross@cdc.gov RI Vinnicombe, Sarah/C-2606-2012 FU Wisconsin Women's Health Foundation FX This study was funded in part by a Grant from the Wisconsin Women's Health Foundation. NR 52 TC 26 Z9 26 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-3600 J9 GENET MED JI Genet. Med. PD NOV PY 2009 VL 11 IS 11 BP 783 EP 789 DI 10.1097/GIM.0b013e3181b9b04a PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 527MU UT WOS:000272372000004 PM 19752737 ER PT J AU Rivera-Marrero, C Song, XZ Lasanajak, Y Luyai, A Willard, M Wilkins, P Secor, WE Smith, D Cummings, R AF Rivera-Marrero, Carlos Song, Xuezheng Lasanajak, Yi Luyai, Anthony Willard, Margaret Wilkins, Patricia Secor, W. Evan Smith, David Cummings, Richard TI Identification of Schistosoma Mansoni Egg Immunodominant Glycan Antigens by the Use of Natural Glycan Microarrays SO GLYCOBIOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Glycobiology CY NOV 12-15, 2009 CL San Diego, CA SP Soc* Glycobiol C1 [Rivera-Marrero, Carlos; Song, Xuezheng; Lasanajak, Yi; Luyai, Anthony; Willard, Margaret; Smith, David; Cummings, Richard] Emory Univ, Atlanta, GA 30322 USA. [Wilkins, Patricia; Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD NOV PY 2009 VL 19 IS 11 MA 233 BP 1357 EP 1357 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 505PX UT WOS:000270707700243 ER PT J AU Kulkarni, R Soucie, JM Lusher, J Presley, R Shapiro, A Gill, J Manco-Johnson, M Koerper, M Mathew, P Abshire, T Dimichele, D Hoots, K Janco, R Nugent, D Geraghty, S Evatt, B AF Kulkarni, R. Soucie, J. M. Lusher, J. Presley, R. Shapiro, A. Gill, J. Manco-Johnson, M. Koerper, M. Mathew, P. Abshire, T. Dimichele, D. Hoots, K. Janco, R. Nugent, D. Geraghty, S. Evatt, B. CA Haemophilia Treatment Ctr Network TI Sites of initial bleeding episodes, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention's (CDC) Universal Data Collection (UDC) project SO HAEMOPHILIA LA English DT Article DE delivery; diagnosis; epidemiology haemophilia; infants; intracranial haemorrhage ID SCIENTIFIC ADVISORY COUNCIL; INTRACRANIAL HEMORRHAGE; CLINICAL PRESENTATION; INHIBITOR DEVELOPMENT; RISK-FACTORS; VITAMIN-K; MANAGEMENT; DISORDERS; NEWBORN; OBSTETRICIANS AB Lack of detailed natural history and outcomes data for neonates and toddlers with haemophilia hampers the provision of optimal management of the disorder. We report an analysis of prospective data collected from 580 neonates and toddlers aged 0-2 years with haemophilia enrolled in the Universal Data Collection (UDC) surveillance project of the Centers for Disease Control and Prevention (CDC). This study focuses on a cohort of babies with haemophilia whose diagnosis was established before the age of two. The mode of delivery, type and severity of haemophilia, onset and timing of haemorrhages, site(s) of bleeding, provision of prophylaxis with coagulation factor replacement therapy, and the role played by the federally funded Haemophilia Treatment Centers (HTC) in the management of these infants with haemophilia were evaluated. Seventy-five per cent of haemophilic infants were diagnosed early, in the first month of life, especially those with a family history or whose mothers were known carriers; infants of maternal carriers were more likely to be delivered by C-section. Involvement of an HTC prior to delivery resulted in avoidance of the use of assisted deliveries with vacuum and forceps. Bleeding from the circumcision site was the most common haemorrhagic complication, followed by intra- and extra-cranial haemorrhages and bleeding from heel stick blood sampling. Eight per cent of the infants were administered factor concentrate within 24 h of birth; more than half were treated to prevent bleeding. This study highlights the significant rate and the sites of initial bleeding unique to very young children with haemophilia and underscores the need for research to identify optimal evidence-based recommendations for their management. C1 [Kulkarni, R.; Soucie, J. M.; Presley, R.] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA. [Kulkarni, R.] Michigan State Univ, Lansing, MI USA. [Lusher, J.] Wayne State Univ, Detroit, MI USA. [Shapiro, A.] Indiana Haemophilia & Thrombosis Ctr, Indianapolis, IN USA. [Gill, J.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Gill, J.] Blood Ctr Wisconsin, Milwaukee, WI USA. [Manco-Johnson, M.; Geraghty, S.] Univ Colorado Denver, Aurora, CO USA. [Manco-Johnson, M.; Geraghty, S.] Hlth Sci Ctr, Aurora, CO USA. [Koerper, M.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Mathew, P.] Univ New Mexico, Albuquerque, NM 87131 USA. [Abshire, T.] Emory Univ, Atlanta, GA 30322 USA. [Dimichele, D.] Weill Cornell Med Coll, New York, NY USA. [Hoots, K.] Gulf States Haemophilia & Thrombophilia Ctr, Houston, TX USA. [Janco, R.] Wyeth Pharmaceut, Collegeville, PA USA. [Nugent, D.] Childrens Hosp Orange Cty, Orange, CA 92668 USA. [Evatt, B.] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA. RP Kulkarni, R (reprint author), Michigan State Univ, Div Pediat & Adolescent Hematol Oncol, E Lansing, MI 48824 USA. EM roshni.kulkarni@hc.msu.edu RI Kerlin, Bryce/E-3369-2011 OI Kerlin, Bryce/0000-0002-1756-8271 FU CDC funded Hemophilia Treatment Centers in the US FX The authors thank all the physicians, nurses, staff, patients and their families of the CDC funded Hemophilia Treatment Centers in the US, on whose behalf this report is submitted. NR 33 TC 41 Z9 41 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1351-8216 J9 HAEMOPHILIA JI Haemophilia PD NOV PY 2009 VL 15 IS 6 BP 1281 EP 1290 DI 10.1111/j.1365-2516.2009.02074.x PG 10 WC Hematology SC Hematology GA 511SN UT WOS:000271187500015 PM 19637999 ER PT J AU Howard, DH Richardson, LC Thorpe, KE AF Howard, David H. Richardson, Lisa C. Thorpe, Kenneth E. TI Cancer Screening And Age In The United States And Europe SO HEALTH AFFAIRS LA English DT Article ID BREAST-CANCER; MAMMOGRAPHY USE; MONICA PROJECT; PREVALENCE; HYPERTENSION; WOMEN; MORTALITY; COUNTRIES; AWARENESS; DISEASE AB We compare cancer screening rates between the United States and Europe. Many European countries have organized screening programs, whereas the U. S. approach is relatively decentralized. Many European countries, unlike the United States, also impose upper age limits on screening. Overall, European screening rates were 22-88 percent of the corresponding U. S. rates. U. S. residents are more likely to be screened at younger ages, when the expected benefit from early detection is the greatest, but also at older ages, when the expected benefit is declining. [Health Aff (Millwood). 2009;28(6):1838-47] C1 [Howard, David H.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. [Richardson, Lisa C.] Ctr Dis Control & Prevent, Comprehens Canc Control Branch, Div Canc Prevent & Control, Atlanta, GA USA. RP Howard, DH (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. EM david.howard@emory.edu FU American Cancer Society, Mentored Research Scholar [MRSG-06-075-01-CPHPS] FX An earlier version of this paper was presented at the 2007 Academy Health Annual Research Meeting in Orlando, Florida. This research was funded by the American Cancer Society, Mentored Research Scholar Grant no. MRSG-06-075-01-CPHPS (DavidHoward, principal investigator). This study used the linked SEER (Surveillance, Epidemiology, and End Results)-Medicare database. The interpretation and reporting of these data are the sole responsibility of the authors. The authors acknowledge the efforts of the Applied Research Program, National Cancer Institute; the Office of Research, Development, and Information, Centers for Medicare and Medicaid Services; NR 26 TC 18 Z9 18 U1 2 U2 2 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD NOV-DEC PY 2009 VL 28 IS 6 BP 1838 EP 1847 DI 10.1377/hlthaff.28.6.1838 PG 10 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA 517NR UT WOS:000271622300028 PM 19887425 ER PT J AU Stern, AM Cetron, MS Markel, H AF Stern, Alexandra M. Cetron, Martin S. Markel, Howard TI Closing The Schools: Lessons From The 1918-19 US Influenza Pandemic SO HEALTH AFFAIRS LA English DT Article ID UNITED-STATES; CLOSURE; INTERVENTIONS; TRANSMISSION; STRATEGIES; SIMULATION; CITIES; STRAIN AB When the novel strain of A/H1N1 influenza first appeared in spring 2009, closing schools was initially a common and often challenging strategy implemented in many communities. Arguments for and against closing schools are likely to arise anew if influenza spikes in the fall of 2009. Policymakers and community officials considering this and other nonpharmaceutical responses can learn from the experiences of ninety-one years ago, during the 1918-19 influenza pandemic that killed thousands of Americans. Analysis of the school closure policies of forty-three U. S. cities during that pandemic shows that smooth implementation was associated with clear lines of authority among agencies and with transparent communication between health officials and the public. [Health Aff (Millwood). 2009; 28(6): w1066-78 (published online 29 September 2009; 10.1377/hlthaff.28.6.w1066)] C1 [Stern, Alexandra M.] Univ Michigan, Sch Med, Ctr Hist Med, Ann Arbor, MI 48109 USA. [Cetron, Martin S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. RP Stern, AM (reprint author), Univ Michigan, Sch Med, Ctr Hist Med, Ann Arbor, MI 48109 USA. EM amstern@umich.edu FU Robert Wood Johnson Foundation; Centers for Disease Control and Prevention [000HCVKC-2007-44323] FX Support for this article was provided in part by a Robert Wood Johnson Foundation Investigator Award in Health Policy Research and the Centers for Disease Control and Prevention (Project no. 000HCVKC-2007-44323). The authors thank Daniel M. Fox for his incisive comments on an earlier draft and Mary Beth Reilly for superb research assistance. NR 27 TC 8 Z9 9 U1 0 U2 1 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD NOV-DEC PY 2009 VL 28 IS 6 BP W1066 EP W1078 DI 10.1377/hlthaff.28.6.w1066 PG 13 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA 517NR UT WOS:000271622300053 PM 19797251 ER PT J AU Logan, JE Karch, DL Crosby, AE AF Logan, Joseph E. Karch, Debra L. Crosby, Alexander E. TI Reducing "Unknown" Data in Violent Death Surveillance: A Study of Death Certificates, Coroner/Medical Examiner and Police Reports From the National Violent Death Reporting System, 2003-2004 SO HOMICIDE STUDIES LA English DT Article DE surveillance; homicide; suicide; violent death surveillance AB To better understand the determinants of violent deaths, researchers need surveillance systems that include a broad spectrum of information (e.g., victim demographics, event characteristics [date/location of death] and preceding circumstances). Missing information can limit the ability to develop preventive interventions. This study examines the value of using multiple source documents (i.e., death certificates, coroner/medical examiner reports, and police reports) to reduce missing or "unknown" data on violent deaths. When all sources are accessible, more sources should reduce the amount of unknown data. This study finds this to be true only for certain variables, that is, those capturing preceding circumstances. C1 [Logan, Joseph E.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30341 USA. RP Logan, JE (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, 4770 Buford Highway NE,Mailstop F-63, Atlanta, GA 30341 USA. EM ffa3@cdc.gov NR 8 TC 5 Z9 7 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1088-7679 J9 HOMICIDE STUD JI Homicide Stud. PD NOV PY 2009 VL 13 IS 4 BP 385 EP 397 DI 10.1177/1088767909348323 PG 13 WC Criminology & Penology SC Criminology & Penology GA 511PJ UT WOS:000271178300003 ER PT J AU Branum, AM Parker, JD Schoendorf, KC AF Branum, Amy M. Parker, Jennifer D. Schoendorf, Kenneth C. TI Trends in US sex ratio by plurality, gestational age and race/ethnicity SO HUMAN REPRODUCTION LA English DT Article DE sex ratio; statistics; epidemiology; USA; ethnicity ID UNITED-STATES; INFANT-MORTALITY; BIRTH; INDUCTION; OVULATION; TIME AB BACKGROUND: The sex ratio in the USA has declined over recent decades, resulting in fewer male births. Concurrent changes in the childbearing population may have influenced the sex ratio, including increases in multiple births, improvements in perinatal survival and increased Hispanic births. METHODS: Data from the US natality files (1981-2006) were analyzed to determine the impact of changes in birth characteristics on male birth proportion. Male birth proportion was calculated as the number of male births divided by the total number. In separate analyses, trends in male birth proportion from 1981 to 2006 were adjusted for plurality (singleton, multiple), gestational age (< 28, 28-32, 33-36, >= 37 weeks) and, from 1989, maternal Hispanic ethnicity. Separate analyses were conducted for white and black births. Log binomial regression was performed to estimate crude and adjusted trends with year as independent variable. RESULTS: Trends in male birth proportion differed significantly according to plurality among white (P < 0.01), but not black births. Adjustment for gestational age tempered the trends among white singletons (P < 0.0001) and multiples (P < 0.05) but had no effect on trends in black male birth proportion. Adjustment for Hispanic ethnicity had no impact on trends in black male birth proportion and any effect on white births was negated by changes in gestational age trends. CONCLUSIONS: Lack of consistent influences on, or patterns of change in, the proportion of male births between different subpopulations of births suggests that a single mechanism is unlikely to explain the oft-referenced decrease in the overall US sex ratio. C1 [Branum, Amy M.; Schoendorf, Kenneth C.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Infant Child & Womens Hlth Stat Branch, Off Anal & Epidemiol, Hyattsville, MD 20782 USA. RP Branum, AM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Infant Child & Womens Hlth Stat Branch, Off Anal & Epidemiol, 3311 Toledo Rd,Room 6113, Hyattsville, MD 20782 USA. EM ambranum@cdc.gov FU Centers for Disease Control and Prevention under the US Department of Health and Human Services FX This work was performed at the Centers for Disease Control and Prevention under the US Department of Health and Human Services. NR 24 TC 4 Z9 4 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD NOV PY 2009 VL 24 IS 11 BP 2936 EP 2944 DI 10.1093/humrep/dep255 PG 9 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 510RE UT WOS:000271107700034 PM 19654108 ER PT J AU Cummings, KJ Smith, TS Shogren, ES Khakoo, R Nanda, S Bunner, L Smithmyer, A Soccorsi, D Kashon, ML Mazurek, GH Friedman, LN Weissman, DN AF Cummings, Kristin J. Smith, Tamara S. Shogren, Elizabeth S. Khakoo, Rashida Nanda, Sharmilarani Bunner, Lana Smithmyer, Ann Soccorsi, Darlene Kashon, Michael L. Mazurek, Gerald H. Friedman, Lloyd N. Weissman, David N. TI Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID CELL ASSAYS; GAMMA; DIAGNOSIS AB We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression. C1 [Cummings, Kristin J.; Shogren, Elizabeth S.; Weissman, David N.] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Kashon, Michael L.] NIOSH, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Smith, Tamara S.] W Virginia Univ, Sch Med, Sect Allergy & Immunol, Dept Pediat, Morgantown, WV 26506 USA. [Khakoo, Rashida] W Virginia Univ, Dept Med, Sch Med, Infect Dis Sect, Morgantown, WV 26506 USA. [Bunner, Lana] W Virginia Univ, Univ Hlth Associates, Morgantown, WV 26506 USA. [Smithmyer, Ann; Soccorsi, Darlene] W Virginia Univ Hosp, Employee Hlth Dept, Morgantown, WV USA. [Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Friedman, Lloyd N.] Yale Univ, Sch Med, New Haven, CT USA. RP Cummings, KJ (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS 2800, Morgantown, WV 26505 USA. EM cvx5@cdc.gov FU National Institute of Environmental Health Sciences [IAG Y1-E5-0001] FX This work was supported in part by an interagency agreement from the National Institute of Environmental Health Sciences (IAG Y1-E5-0001 Immunotoxicity of Workplace Xenobiotics). NR 10 TC 14 Z9 14 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD NOV PY 2009 VL 30 IS 11 BP 1123 EP 1126 DI 10.1086/644754 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 503RI UT WOS:000270556600016 PM 19803719 ER PT J AU White, LF Wallinga, J Finelli, L Reed, C Riley, S Lipsitch, M Pagano, M AF White, Laura Forsberg Wallinga, Jacco Finelli, Lyn Reed, Carrie Riley, Steven Lipsitch, Marc Pagano, Marcello TI Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Basic reproductive number; influenza A; H1N1 outbreak; serial interval ID UNITED-STATES; STRATEGIES; VIRUS; TRANSMISSIBILITY; EPIDEMIC; OUTBREAK; A(H1N1) AB Background The United States was the second country to have a major outbreak of novel influenza A/H1N1 in what has become a new pandemic. Appropriate public health responses to this pandemic depend in part on early estimates of key epidemiological parameters of the virus in defined populations. Methods We use a likelihood-based method to estimate the basic reproductive number (R(0)) and serial interval using individual level U.S. data from the Centers for Disease Control and Prevention (CDC). We adjust for missing dates of illness and changes in case ascertainment. Using prior estimates for the serial interval we also estimate the reproductive number only. Results Using the raw CDC data, we estimate the reproductive number to be between 2 center dot 2 and 2 center dot 3 and the mean of the serial interval (mu) between 2 center dot 5 and 2 center dot 6 days. After adjustment for increased case ascertainment our estimates change to 1 center dot 7 to 1 center dot 8 for R(0) and 2 center dot 2 to 2 center dot 3 days for mu. In a sensitivity analysis making use of previous estimates of the mean of the serial interval, both for this epidemic (mu = 1 center dot 91 days) and for seasonal influenza (mu = 3 center dot 6 days), we estimate the reproductive number at 1 center dot 5 to 3 center dot 1. Conclusions With adjustments for data imperfections we obtain useful estimates of key epidemiological parameters for the current influenza H1N1 outbreak in the United States. Estimates that adjust for suspected increases in reporting suggest that substantial reductions in the spread of this epidemic may be achievable with aggressive control measures, while sensitivity analyses suggest the possibility that even such measures would have limited effect in reducing total attack rates. C1 [White, Laura Forsberg] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Wallinga, Jacco] Ctr Infect Dis Control Netherlands, Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands. [Wallinga, Jacco] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Finelli, Lyn; Reed, Carrie] CDC, Epidemiol & Prevent Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA. [Riley, Steven] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China. [Riley, Steven] Univ Hong Kong, Dept Community Med, Hong Kong, Hong Kong, Peoples R China. [Lipsitch, Marc] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Pagano, Marcello] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP White, LF (reprint author), Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave, Boston, MA 02118 USA. EM lfwhite@bu.edu OI White, Laura/0000-0002-0588-8235; Wallinga, Jacco/0000-0003-1725-5627; Lipsitch, Marc/0000-0003-1504-9213 FU National Institutes of Health [R01 EB0061695]; Models of Infectious Disease Agents Study [5U01GM076497, 1U54GM088588]; Harvard Center for Communicable Disease Dynamics FX This work was funded in part by the National Institutes of Health, R01 EB0061695 and Models of Infectious Disease Agents Study program through cooperative agreements 5U01GM076497 and and 1U54GM088588 to ML, the latter for the Harvard Center for Communicable Disease Dynamics. NR 21 TC 118 Z9 120 U1 3 U2 8 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD NOV PY 2009 VL 3 IS 6 BP 267 EP 276 DI 10.1111/j.1750-2659.2009.00106.x PG 10 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 509WI UT WOS:000271049600005 PM 19903209 ER PT J AU Buss, BF Shinde, VM Safranek, TJ Uyeki, TM AF Buss, Bryan F. Shinde, Vivek M. Safranek, Thomas J. Uyeki, Timothy M. TI Pediatric influenza-associated myositis - Nebraska, 2001-2007 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Epidemiology; influenza; myositis; rhabdomyolysis; pediatrics ID ACUTE CHILDHOOD MYOSITIS; ACUTE TRANSIENT MYOSITIS; B VIRUS; UNITED-STATES; CHILDREN; HOSPITALIZATIONS; INFECTION; EPIDEMIC AB Objective Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. Methods During 2006-2007, we requested reports of severe influenza illness among persons aged < 18 years and investigated medical records to identify and confirm IAM cases defined as severe myalgia with elevated serum creatinine kinase level in a patient aged < 18 years, occurring within 7 days of laboratory confirmed influenza illness onset. Statewide hospital discharge data (HDD) were reviewed to identify retrospectively confirmed IAM cases during 2006-2007 and five previous seasons, by using surveillance data to define periods of influenza activity. Statewide IAM incidence was estimated for 2001-2002 through 2006-2007. Results During 2006-2007, a total of 13 IAM cases were confirmed by enhanced surveillance. Median age was 6 years (range, 4-11 years). Influenza diagnosis was established by viral isolation from six patients (one influenza A and five influenza B) and rapid diagnostic tests for seven. Twelve (92%) patients, including one who died, were hospitalized for a median of 3 days (range, 1-4 days). Review of HDD identified 12 retrospectively confirmed IAM cases during 2006-2007, including four not reported through enhanced surveillance, and only one during five previous seasons (2003-2004). The HDD-derived, retrospectively confirmed statewide IAM incidence estimates/1 00 000 population aged < 18 years were 2 center dot 693 and 0 center dot 225 during 2006-2007 and 2003-2004, respectively. Conclusion An IAM epidemic occurred in Nebraska during the 2006-2007 influenza season. C1 [Buss, Bryan F.] CDC, Div Publ Hlth, Nebraska Dept Hlth & Human Serv, Off Epidemiol, Lincoln, NE 68509 USA. [Buss, Bryan F.; Shinde, Vivek M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Shinde, Vivek M.; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Buss, BF (reprint author), CDC, Div Publ Hlth, Nebraska Dept Hlth & Human Serv, Off Epidemiol, 301 Centennial Mall S,POB 95026, Lincoln, NE 68509 USA. EM bryan.buss@nebraska.gov NR 35 TC 4 Z9 4 U1 2 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD NOV PY 2009 VL 3 IS 6 BP 277 EP 285 DI 10.1111/j.1750-2659.2009.00102.x PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 509WI UT WOS:000271049600006 PM 19903210 ER PT J AU Dong, J Matsuoka, Y Maines, TR Swayne, DE O'Neill, E Davis, CT Van-Hoven, N Balish, A Yu, HJ Katz, JM Klimov, A Cox, N Li, DX Wang, Y Guo, YJ Yang, WZ Donis, RO Shu, YL AF Dong, Jie Matsuoka, Yumiko Maines, Taronna R. Swayne, David E. O'Neill, Eduardo Davis, C. Todd Van-Hoven, Neal Balish, Amanda Yu, Hong-jie Katz, Jacqueline M. Klimov, Alexander Cox, Nancy Li, De-xin Wang, Yu Guo, Yuan-ji Yang, Wei-zhong Donis, Ruben O. Shu, Yue-long TI Development of a new candidate H5N1 avian influenza virus for pre-pandemic vaccine production SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Pandemic influenza; H5N1 vaccine; seed virus ID A VIRUS; REVERSE GENETICS; HEMAGGLUTININ; EVOLUTION; INFECTION; ASIA; SUBTYPES; ORIGIN; CELLS AB Background Highly pathogenic H5N1 avian influenza viruses currently circulating in birds have caused hundreds of human infections, and pose a significant pandemic threat. Vaccines are a major component of the public health preparedness for this likely event. The rapid evolution of H5N1 viruses has resulted in the emergence of multiple clades with distinct antigenic characteristics that require clade-specific vaccines. A variant H5N1 virus termed clade 2.3.4 emerged in 2005 and has caused multiple fatal infections. Vaccine candidates that match the antigenic properties of variant viruses are necessary because inactivated influenza vaccines elicit strain-specific protection. Objective To address the need for a suitable seed for manufacturing a clade 2.3.4 vaccine, we developed a new H5N1 pre-pandemic candidate vaccine by reverse genetics and evaluated its safety and replication in vitro and in vivo. Methods A reassortant virus termed, Anhui/PR8, was produced by reverse genetics in compliance with WHO pandemic vaccine development guidelines and contains six genes from A/Puerto Rico/8/34 as well as the neuraminidase and hemagglutinin (HA) genomic segments from the A/Anhui/01/2005 virus. The multi-basic cleavage site of HA was removed to reduce virulence. Results The reassortant Anhui/PR8 grows well in eggs and is avirulent to chicken and ferrets but retains the antigenicity of the parental A/Anhui/01/2005 virus. Conclusion These results indicate that the Anhui/PR8 reassortant lost a major virulent determinant and it is suitable for its use in vaccine manufacturing and as a reference vaccine virus against the H5N1 clade 2.3.4 viruses circulating in eastern China, Vietnam, Thailand, and Laos. C1 [Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, NCIRD, CCID, Atlanta, GA 30333 USA. [Dong, Jie; Yu, Hong-jie; Li, De-xin; Wang, Yu; Guo, Yuan-ji; Yang, Wei-zhong; Shu, Yue-long] China CDC, Natl Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Chinese Natl Influenza Ctr, Beijing, Peoples R China. [Swayne, David E.] ARS, SE Poultry Res Lab, USDA, Athens, GA USA. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, NCIRD, CCID, 1600 Clifton Rd,Mail Stop G-16, Atlanta, GA 30333 USA. EM rdonis@cdc.gov NR 35 TC 15 Z9 17 U1 0 U2 9 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD NOV PY 2009 VL 3 IS 6 BP 287 EP 295 DI 10.1111/j.1750-2659.2009.00104.x PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 509WI UT WOS:000271049600007 PM 19903211 ER PT J AU Deyde, V Garten, R Sheu, T Smith, C Myrick, A Barnes, J Xu, XY Shaw, M Klimov, A Gubareva, L AF Deyde, Varough Garten, Rebecca Sheu, Tiffany Smith, Catherine Myrick, Allison Barnes, John Xu, Xiyan Shaw, Michael Klimov, Alexander Gubareva, Larisa TI Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Adamantanes; genome; genotype; phylogenetic analysis; resistance ID A H3N2 VIRUSES; AMANTADINE-RESISTANT; ISOLATED WORLDWIDE; GENETIC EVOLUTION; UNITED-STATES; RIMANTADINE; REASSORTMENT; AUSTRALIA; EMERGENCE; SEASON AB Background Adamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions. Objectives To explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 2008. Methods A total of 1451 Influenza A (H3N2) viruses collected globally in 2001-2008 were screened for the presence of adamantane resistance markers. A subset of 100 viruses representing the broad genetic and geographic spectrum of these viruses was selected for complete genome sequencing and phylogenetic analyses. Results Full genome sequence analysis of 2006-2007 viruses revealed co-circulation of four distinct genotypes, designated A-D. Phylogenetic analyses demonstrated reassortment between viruses from the N-lineage and other viruses that had circulated in prior seasons, including those bearing an adamantane sensitive marker. Genotype D viruses became dominant in late 2006-2007 and continued to be the main H3N2 genotype in 2007-2008. Viruses of this genotype retained all N-lineage genome segments except PB2 and NP, which were acquired through reassortment. Conclusions The decrease in adamantane resistance at that time was due to transient co-circulation of genotypes that emerged through reassortment. Our findings emphasize the importance of complete genome sequencing in understanding the complex nature of the relationship between influenza virus evolution and antiviral resistance. The recent emergence of the pandemic multi-reassortant H1N1 virus underscores the importance of whole genome sequence monitoring for rapid detection of such unusual and novel strains. C1 [Deyde, Varough; Garten, Rebecca; Sheu, Tiffany; Smith, Catherine; Myrick, Allison; Barnes, John; Xu, Xiyan; Shaw, Michael; Klimov, Alexander; Gubareva, Larisa] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Gubareva, L (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM lqg3@cdc.gov FU US Centers for Disease Control and Prevention FX This work was funded by the US Centers for Disease Control and Prevention. NR 46 TC 17 Z9 17 U1 0 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD NOV PY 2009 VL 3 IS 6 BP 297 EP 314 DI 10.1111/j.1750-2659.2009.00103.x PG 18 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 509WI UT WOS:000271049600008 PM 19903212 ER PT J AU Caldwell, KL Mortensen, ME Jones, RL Caudill, SP Osterloh, JD AF Caldwell, Kathleen L. Mortensen, Mary E. Jones, Robert L. Caudill, Samuel P. Osterloh, John D. TI Total blood mercury concentrations in the US population: 1999-2006 SO INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH LA English DT Article DE Mercury; Human biomonitoring; Exposure; NHANES 1999-2006; Environmental health ID METHYLMERCURY; EXPOSURE; CHILDREN; AMERICAN; GERES AB We describe the distribution and demographic characteristics of total blood Hg levels in the U.S. general population among persons ages I year and older who participated in the 2003-2006 National Health and Nutrition Examination Survey (NHANES). We also describe trends in the total blood Hg of children ages 1-5 (n = 3456) and females ages 16-49 during 1999-2006 (n = 7245). In the combined 2003-2006 survey periods, the geometric means for non-Hispanic blacks, 0.853 mu g/L (95% confidence interval [CI], 0.766-0.950 mu g/L), and non-Hispanic whites, 0.833 mu g/L (95% Cl, 0.752-0.922 mu g/L), were higher than the geometric mean for Mexican Americans, 0.580 mu g/L (95% Cl, 0.522-0.645 mu g/L). Also in 2003-2006, regression analysis of log total blood Hg with age, race/ethnicity and gender showed that total blood Hg levels in the population exhibited a quadratic increase with age (p<0.0001), peaking at ages 50-59 in non-Hispanic blacks and whites, at ages 40-49 in Mexican Americans, and then declining at older ages. Over the four survey periods (1999-2006), regression analysis showed that total blood Hg levels increased slightly for non-Hispanic white children and decreased slightly for non-Hispanic black and Mexican American children. Over the same four survey periods, female children had slightly higher total blood Hg levels than males (0.356 vs. 0.313 mu g/L, p = 0.0050) and total blood Hg levels in non-Hispanic black women aged 16-49 years were significantly higher than in non-Hispanic white women (1.081 vs. 0.850 mu g/L, p<0.0001) and in Mexican American women (1.081 vs. 0.70 mu g/L, p < 0.0001). Published by Elsevier GmbH. C1 [Caldwell, Kathleen L.; Mortensen, Mary E.; Jones, Robert L.; Caudill, Samuel P.; Osterloh, John D.] CDC, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Caldwell, KL (reprint author), CDC, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE,Mailstop F-18, Atlanta, GA 30341 USA. EM kcaldwell@cdc.gov NR 25 TC 55 Z9 56 U1 4 U2 10 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1438-4639 J9 INT J HYG ENVIR HEAL JI Int. J. Hyg. Environ. Health. PD NOV PY 2009 VL 212 IS 6 BP 588 EP 598 DI 10.1016/j.ijheh.2009.04.004 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 526MX UT WOS:000272295300003 PM 19481974 ER PT J AU Abbadi, SH Sameaa, GA Morlock, G Cooksey, RC AF Abbadi, Said H. Sameaa, G. Abdel Morlock, G. Cooksey, R. C. TI Molecular identification of mutations associated with anti-tuberculosis drug resistance among strains of Mycobacterium tuberculosis SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Mycobacterium tuberculosis; Mutations; Multidrug-resistant TB ID NEW-YORK-CITY; STREPTOMYCIN RESISTANCE; ISONIAZID RESISTANCE; GENE-MUTATIONS; RPOB GENE; KATG; ETHAMBUTOL; RIFAMPIN; POLYMORPHISMS; MECHANISMS AB Background: Understanding the etiologic organism, antimicrobial resistance mechanisms, and transmission of multidrug-resistant tuberculosis (MDR-TB) can be of great value in optimizing strategies to control and prevent its development and transmission. Methods: One hundred and fifty-five Mycobacterium tuberculosis complex isolates from patients with pulmonary tuberculosis (TB) in Cairo, Egypt were studied. In vitro drug susceptibility testing against rifampin (RIF), isoniazid (INH), streptomycin (SM), ethambutol (EMB), and pyrazinamide (PZA) was performed. Resistance was studied by the standard agar proportion method. Single strand conformation polymorphism (SSCP) and DNA sequence analysis were used to detect mutations in the genes that encode resistance to rpoB, katG, rpsL, and embB. Results: Among 155 consecutive M. tuberculosis isolates, 25 (16.1%) were MDR-TB; 13 of these were from newly diagnosed untreated cases, 12 were from re-treated cases, and none of the MDR-TB isolates had matching IS6110 fingerprints. Among the MDR-TB isolates, rpoB mutations were found in 76% of RIF-resistant isolates, katG mutations were found in 47.1% of INH-resistant isolates, rpsL mutations were found in 55.6% of SM-resistant isolates, and embB mutations were found in 36.4% of EMB-resistant isolates. Conclusions: No major differences were found in the frequencies of mutations or types of amino acid substitution between newly diagnosed untreated cases and re-treated cases. The high prevalence of MDR-TB at this hospital underscores the need for continuous monitoring of strains and antimicrobial resistance. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. C1 [Abbadi, Said H.] Suez Canal Univ, Fac Med, Dept Microbiol, Ismailia, Egypt. [Sameaa, G. Abdel] VACSERA, Cairo, Egypt. [Morlock, G.; Cooksey, R. C.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Abbadi, SH (reprint author), Suez Canal Univ, Fac Med, Dept Microbiol, Ismailia, Egypt. EM saidabbadi@hotmail.com NR 37 TC 13 Z9 15 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD NOV PY 2009 VL 13 IS 6 BP 673 EP 678 DI 10.1016/j.ijid.2008.10.006 PG 6 WC Infectious Diseases SC Infectious Diseases GA 514DC UT WOS:000271373400005 PM 19138546 ER PT J AU Kingkaew, N Sangtong, B Amnuaiphon, W Jongpaibulpatana, J Mankatittham, W Akksilp, S Sirinak, C Nateniyom, S Burapat, C Kittikraisak, W Monkongdee, P Varma, JK AF Kingkaew, Nara Sangtong, Burachat Amnuaiphon, Waraya Jongpaibulpatana, Jessada Mankatittham, Wiroj Akksilp, Somsak Sirinak, Chawin Nateniyom, Sriprapa Burapat, Channawong Kittikraisak, Wanitchaya Monkongdee, Patama Varma, Jay K. TI HIV-associated extrapulmonary tuberculosis in Thailand: epidemiology and risk factors for death SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Tuberculosis; HIV/AIDS; Extrapulmonary TB ID ACTIVE ANTIRETROVIRAL THERAPY; PULMONARY TUBERCULOSIS; EXTRA-PULMONARY; SEX-DIFFERENCES; HONG-KONG; MORTALITY; ADULTS; COTRIMOXAZOLE; PROPHYLAXIS; MORBIDITY AB Background: We conducted a prospective, multicenter observational cohort study in Thailand to characterize the epidemiology of extrapulmonary tuberculosis (TB) in HIV-infected persons and to identify risk factors for death. Methods: From May 2005 to September 2006, we enrolled, interviewed, examined, and performed laboratory tests on HIV-infected adult TB patients and followed them from TB treatment initiation until the end of TB treatment. We conducted multivariate proportional hazards analysis to identify factors associated with death. Results: Of the 769 patients, pulmonary TB only was diagnosed in 461 (60%), both pulmonary and extrapulmonary TB in 78 (10%), extrapulmonary TB at one site in 223 (29%), and extrapulmonary TB at more than one site in seven (1%) patients. Death during TB treatment occurred in 59 of 308 patients (19%) with any extrapulmonary involvement. In a proportional hazards model, patients with extrapulmonary TB had an increased risk of death if they had meningitis, and a CD4+ T-lymphocyte count < 200 cells/mu l. Patients who received co-trimoxazole, fluconazole, and antiretroviral therapy during TB treatment had a lower risk of death. Conclusions: Among HIV-infected patients with TB, extrapulmonary disease occurred in 40% of the patients, particularly in those with advanced immune suppression. Death during TB treatment was common, but the risk of death was reduced in patients who took co-trimoxazole, fluconazole, and antiretroviral therapy. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. C1 [Burapat, Channawong; Kittikraisak, Wanitchaya; Monkongdee, Patama; Varma, Jay K.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Kingkaew, Nara; Sangtong, Burachat; Amnuaiphon, Waraya; Jongpaibulpatana, Jessada] Vachira Hosp, Phuket, Thailand. [Mankatittham, Wiroj] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Akksilp, Somsak] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Sirinak, Chawin] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand. [Varma, Jay K.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Kittikraisak, W (reprint author), US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. EM wanitchayak@th.cdc.gov FU US Agency for International Development FX Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the US Centers for Disease Control and Prevention. NR 39 TC 33 Z9 33 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD NOV PY 2009 VL 13 IS 6 BP 722 EP 729 DI 10.1016/j.ijid.2008.11.013 PG 8 WC Infectious Diseases SC Infectious Diseases GA 514DC UT WOS:000271373400014 PM 19196530 ER PT J AU Damani, R Ross, MW Aral, SO Berman, S St Lawrence, J Williams, ML AF Damani, R. Ross, M. W. Aral, S. O. Berman, S. St Lawrence, J. Williams, M. L. TI Emotional intimacy predicts condom use: findings in a group at high sexually transmitted disease risk SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE condom use; emotional intimacy; African-American; crack cocaine ID SEX WORKERS; PARTNERS AB Previous studies have reported an inverse relationship between condom use and emotional intimacy. The aim of this study was to determine the relationship between condom use and emotional intimacy. The study was a gonorrhoea. case-comparison study with the samples being drawn from public health clinics (cases) and select bars/nightclubs (places) of Houston, TX (n = 215). Data were collected by questionnaires administered on a laptop computer. The majority of respondents were African-American (97.7%), women (69.3%) and had either high school or GED education (72.6%). Condom use with the last sexual partner or was analysed along with intimacy with that partner assessed on a 3-point scale. Analysis showed that higher intimacy was related to greater condom use which was significant in men but not in women. In conclusion, these data were opposite to those of previous studies, which showed an inverse relationship between condom use and emotional intimacy. We hypothesize that in a high-risk environment, people exert more effort in protecting those they feel closer to. These data suggest a need to further explore the complex relationship between emotional intimacy and condom use. C1 [Damani, R.; Ross, M. W.; Williams, M. L.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA. [Aral, S. O.; Berman, S.; St Lawrence, J.] CDC, Atlanta, GA 30333 USA. RP Ross, MW (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, POB 20036, Houston, TX USA. EM Michael.W.Ross@uth.tmc.edu NR 8 TC 3 Z9 3 U1 0 U2 2 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD NOV PY 2009 VL 20 IS 11 BP 761 EP 764 DI 10.1258/ijsa.2009.009238 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 523TM UT WOS:000272097500007 PM 19875830 ER PT J AU Rodewald, LE Orenstein, WA AF Rodewald, Lance E. Orenstein, Walter A. TI Vaccinating Adolescents-New Evidence of Challenges and Opportunities SO JOURNAL OF ADOLESCENT HEALTH LA English DT Editorial Material ID AGED 13-17 YEARS; UNITED-STATES; COVERAGE C1 [Rodewald, Lance E.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Orenstein, Walter A.] Ctr Dis Control & Prevent, Natl Immunizat Program, Atlanta, GA USA. RP Rodewald, LE (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. OI Rodewald, Lance/0000-0003-2593-542X NR 14 TC 6 Z9 6 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD NOV PY 2009 VL 45 IS 5 BP 427 EP 429 DI 10.1016/j.jadohealth.2009.08.006 PG 3 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 513HR UT WOS:000271313800001 PM 19837347 ER PT J AU Gottlieb, SL Brewer, NT Sternberg, MR Smith, JS Ziarnowski, K Liddon, N Markowitz, LE AF Gottlieb, Sami L. Brewer, Noel T. Sternberg, Maya R. Smith, Jennifer S. Ziarnowski, Karen Liddon, Nicole Markowitz, Lauri E. TI Human Papillomavirus Vaccine Initiation in an Area with Elevated Rates of Cervical Cancer SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Human papillomavirus; HPV vaccines; Immunization; Adolescent ID UNITED-STATES; HPV VACCINE; RISK; DISPARITIES; STUDENTS AB Purpose: We assessed human papillomavirus (HPV) vaccination of adolescent girls living in communities with elevated cervical cancer rates. Methods: During July to October 2007, we conducted interviews with a probability sample of parents (or guardians) of 10- to 18-year-old girls in five North Carolina counties with cervical cancer rates substantially higher than the national average. Estimates are weighted. Results: We interviewed 889 (73%) of 1220 eligible parents; 38% were black. Overall, 10.3% (95% confidence interval [CI] 7.7%-13.5%) of daughters had received at least 1 dose of HPV vaccine. Only 6.4% of 10- to 12-year-olds had initiated vaccination, versus 17.5% of 16- to 18-year-olds (odds ratio [OR] 3.1, 95% CI 1.4-6.9). Older age of daughters and doctor's recommendation were the only factors independently associated with vaccine initiation. Main reasons reported for not initiating HPV vaccine were: needing more information (22%) or never having heard of the vaccine (14%), believing daughter is too young (16%) or not yet sexually active (13%), and not having gone to the doctor yet (13%). Only 0.5% of parents cited concern about HPV vaccine making a teenage girl more likely to have sex as a main reason for not vaccinating. Of 780 parents with unvaccinated daughters, 62% reported their daughters "probably" or "definitely" will, and 10% reported their daughters "definitely won't" get HPV vaccine in the next year. Conclusions: Approximately 1 year after its introduction, HPV vaccine had been initiated by only 10% of adolescent girls in an area with elevated cervical cancer rates; however, most parents intended for their daughters to be vaccinated. Additional efforts are needed to ensure that parents' intentions to vaccinate are realized. Published by Elsevier Inc. on behalf of Society for Adolescent Medicine. C1 [Gottlieb, Sami L.; Sternberg, Maya R.; Liddon, Nicole; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Brewer, Noel T.; Smith, Jennifer S.; Ziarnowski, Karen] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. RP Gottlieb, SL (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM sgottlieb@cdc.gov FU Centers for Disease Control and Prevention [S3715-25/25]; American Cancer Society [MSRG-06-259-O1-CPPB] FX This study was funded by grants from the Centers for Disease Control and Prevention (S3715-25/25) and the American Cancer Society (MSRG-06-259-O1-CPPB). The authors thank Robert Agans, William Kalsbeek, and staff at the University of North Carolina Survey Research Unit for their invaluable help in conducting the study. We also thank Andrea Held at the Immunization Branch of the North Carolina Department of Health and Human Services for her helpful information as we planned and conducted the study. NR 21 TC 54 Z9 54 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD NOV PY 2009 VL 45 IS 5 BP 430 EP 437 DI 10.1016/j.jadohealth.2009.03.029 PG 8 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 513HR UT WOS:000271313800002 PM 19837348 ER PT J AU Gottlieb, SL Brewer, NT Smith, JS Keating, KM Markowitz, LE AF Gottlieb, Sami L. Brewer, Noel T. Smith, Jennifer S. Keating, Katie M. Markowitz, Lauri E. TI Availability of Human Papillomavirus Vaccine at Medical Practices in an Area with Elevated Rates of Cervical Cancer SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Human papillomavirus; HPV vaccines; Adolescent health services ID PNEUMOCOCCAL CONJUGATE VACCINE; NATIONAL-SURVEY; UNITED-STATES; IMMUNIZATION; RECOMMENDATIONS; REIMBURSEMENT; PEDIATRICIANS; ADOLESCENTS; PHYSICIANS; ADHERENCE AB Purpose: To assess availability of human papillomavirus (HPV) vaccine at medical practices in an area with elevated cervical cancer rates. Methods: During July-November 2007, we conducted a telephone survey of staff at medical practices providing outpatient care to 9- to 26-year-old females in four North Carolina counties with elevated cervical cancer rates. We assessed availability of HPV vaccine and concerns about its provision. Results: Staff from 71 of 96 eligible practices completed a full interview. Overall, 62% of these practices had HPV vaccine available to patients (family practice, 74%; pediatrics, 75%; obstetrics-gynecology, 64%; internal medicine, 15%). In multivariate analysis, practice characteristics that independently predicted a lower likelihood of carrying HPV vaccine were having at least 50% African-American patient population (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.06-0.63) and providing only privately purchased (and no state-supplied) vaccines (OR 0.19, 95% CI 0.06-0.63). HPV vaccine nonproviders were significantly more likely than HPV vaccine providers to report "large" concerns about the up-front costs of purchasing HPV vaccine (52% vs. 27%, p <.05) and late reimbursement (33% vs. 14%, p <.05). Conclusions: Approximately 1 year after its introduction, HPV vaccine was available at three-quarters of family practice and pediatrics practices, two-thirds of obstetrics-gynecology practices, and few internal medicine practices in an area with elevated cervical cancer rates. Practices' concerns about cost and reimbursement have implications for accessibility of HPV vaccine to those who need it most. Published by Elsevier Inc. on behalf of Society for Adolescent Medicine. C1 [Gottlieb, Sami L.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Brewer, Noel T.; Smith, Jennifer S.; Keating, Katie M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. RP Gottlieb, SL (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM sgottlieb@cdc.gov FU Centers for Disease Control and Prevention [S3715-25/25]; American Cancer Society [MSRG-06-259-O1-CPPB] FX The study was funded by grants from the Centers for Disease Control and Prevention (S3715-25/25) and the American Cancer Society (MSRG-06-259-O1-CPPB). The authors thank Christina Ludetna, Yuli Chang, and Karen Ziarnowski for their help in conducting the study, Susan Hariri and Maya Sternberg for their comments on the analysis, and Shannon Stokley for her careful reading of the manuscript. We also thank Andrea Held at the Immunization Branch of the North Carolina Department of Health and Human Services and staff at the County Health Departments, including Evelyn Coley, llla Davis, Debbie Hobbs, Maureen Mercer, Wayne Raynor, Wanda Robinson, John Roose, and Wanda Tart, for their helpful information as we planned and conducted the study. NR 25 TC 8 Z9 8 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD NOV PY 2009 VL 45 IS 5 BP 438 EP 444 DI 10.1016/j.jadohealth.2009.05.013 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 513HR UT WOS:000271313800003 PM 19837349 ER PT J AU Daley, MF Curtis, CR Pyrzanowski, J Barrow, J Benton, K Abrams, L Federico, S Juszczak, L Melinkovich, P Crane, LA Kempe, A AF Daley, Matthew F. Curtis, C. Robinette Pyrzanowski, Jennifer Barrow, Jennifer Benton, Kathryn Abrams, Lisa Federico, Steven Juszczak, Linda Melinkovich, Paul Crane, Lori A. Kempe, Allison TI Adolescent Immunization Delivery in School-Based Health Centers: A National Survey SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Immunization; Vaccine; Adolescent; School-based health centers; Schools ID UNITED-STATES; MEDICAL HOME; CARE; VACCINATION; DISPARITIES; US; PHYSICIANS; VACCINES; SERVICES; POLICIES AB Purpose: Vaccinating adolescents in a variety of settings may be needed to achieve high vaccination coverage. School-based health centers (SBHCS) provide a wide range of health services, but little is known about immunization delivery in SBHCs. The objective of this investigation was to assess, in a national random sample of SBHCs, adolescent immunization practices and perceived barriers to vaccination. Methods: One thousand SBHCs were randomly selected from a national database. Surveys were conducted between November 2007 and March 2008 by Internet and standard mail. Results: Of 815 survey-eligible SBHCs, 521 (64%) responded. Of the SBHCs, 84% reported vaccinating adolescents, with most offering tetanus-diphtheria-acellular pertussis, ineningococcal conjugate, and human papillomavirus vaccines. Among SBHCs that vaccinated adolescents, 96% vaccinated Medicaid-insured and 98% vaccinated uninsured students. Although 93% of vaccinating SBHCs participated in the Vaccines for Children program, only 39% billed private insurance for vaccines given. A total of 69% used an electronic database or registry to track vaccines given, and 83%n sent reminders to adolescents and/or their parents if immunizations were needed. For SBHCs that did not offer vaccines, difficulty billing private insurance was the most frequently cited barrier to vaccination. Conclusions: Most SBHCs appear to be fully involved in immunization delivery to adolescents, offering newly recommended vaccines and performing interventions such as reminder/recall to improve immunization rates. Although the number of SBHCs is relatively small, with roughly 2000 nationally, SBHCs appear to be an important vaccination resource, particularly for low income and uninsured adolescents who may have more limited access to vaccination elsewhere. (C) 2009 Society for Adolescent Medicine. All rights reserved. C1 [Daley, Matthew F.; Pyrzanowski, Jennifer; Barrow, Jennifer; Benton, Kathryn; Crane, Lori A.; Kempe, Allison] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO 80045 USA. [Daley, Matthew F.; Melinkovich, Paul; Kempe, Allison] Univ Colorado Denver Sch Med, Dept Pediat, Aurora, CO 80045 USA. [Daley, Matthew F.; Pyrzanowski, Jennifer; Barrow, Jennifer; Benton, Kathryn; Kempe, Allison] Univ Colorado Denver Sch Med, Colorado Hlth Outcomes Program, Aurora, CO USA. [Crane, Lori A.] Colorado Sch Publ Hlth, Dept Community & Behav Hlth, Aurora, CO USA. [Curtis, C. Robinette] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Abrams, Lisa; Federico, Steven; Melinkovich, Paul] Denver Hlth & Hosp Author, Denver, CO USA. [Juszczak, Linda] Natl Assembly Sch Based Hlth Care, Washington, DC USA. RP Daley, MF (reprint author), Childrens Hosp, Childrens Outcomes Res Program, Mailstop F443,12477 E 19th Ave, Aurora, CO 80045 USA. EM daley.matthew@tchden.org FU Centers for Disease Control and Prevention [1-U01-IP000110] FX This investigation was supported by Cooperative Agreement # 1-U01-IP000110 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are solely the responsibility of the authors, and do not necessarily represent the official views of the Centers for Disease Control and Prevention (CDC) or the National Assembly on School-Based Health Care (NASBHC). The first author (MFD) had full access to all of the data in this study and takes responsibility for the integrity of the data and the accuracy of the data analysis. NR 38 TC 27 Z9 27 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD NOV PY 2009 VL 45 IS 5 BP 445 EP 452 DI 10.1016/j.jadohealth.2009.04.002 PG 8 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 513HR UT WOS:000271313800004 PM 19837350 ER PT J AU Li, L Chen, DR Qi, C Kulkarni, PS AF Li, Lin Chen, Da-Ren Qi, Chaolog Kulkarni, Pramod S. TI A miniature disk electrostatic aerosol classifier (mini-disk EAC) for personal nanoparticle sizers SO JOURNAL OF AEROSOL SCIENCE LA English DT Article DE Miniature mobility classifier; Nanoparticle sizer; Personal aerosol exposure ID CARBON NANOTUBES; SAMPLER; INSTILLATION; EMISSIONS; TOXICITY AB We have developed a miniature disk electrostatic aerosol classifier (mini-disk EAC) for use in electrical mobility-based personal nanoparticle instrumentation for measurement of personal exposures to nanoaerosols. The prototype consists of two parallel disk electrodes separated by an electrically insulating spacer, to create the particle classification zone. The aerosol enters and exits the classification zone along the bottom disk electrode. An additional, particle-free sheath flow is used to improve the measurement resolution. The transmission measurement of the mini-disk EAC for DMA-classified particles shows that particle losses due to diffusion and electrical image forces were low. The particle penetration at 10 nm diameter (the designed lower size limit for the classifier) was 67% when the prototype was operated at the aerosol and sheath flow rates of 0.5 and 1.01 min(-1) respectively. The performance of the mini-disk EAC was experimentally characterized using the particle cutoff curves that describe their penetration through the classifier as a function of applied voltage across the two disk electrodes. Based on the measurement of particle penetration at different aerosol and sheath flows, it was found that the aerosol and sheath flow rates of 0.5 and 1.5 l min(-1) were optimal for classifier operation. Finally, a semi-empirical model was also developed to describe the transfer function of the mini-disk EAC for non-diffusive particles. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Li, Lin; Chen, Da-Ren] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Qi, Chaolog; Kulkarni, Pramod S.] Ctr Dis Control & Prevent, NIOSH, Cincinnati, OH 45226 USA. RP Chen, DR (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, 1 Brookings Dr,Box 1180, St Louis, MO 63130 USA. EM chen@wustl.edu RI li, lin/D-7584-2014 OI li, lin/0000-0002-8120-2442 FU National Institute for Occupational Safety and Health [22-001322-62343] FX LL and DRC are grateful for the financial support provided by National Institute for Occupational Safety and Health through the subcontract (#22-001322-62343) to Washington University in St. Louis. NR 23 TC 8 Z9 8 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-8502 J9 J AEROSOL SCI JI J. Aerosol. Sci. PD NOV PY 2009 VL 40 IS 11 BP 982 EP 992 DI 10.1016/j.jaerosci.2009.09.003 PG 11 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 523ZI UT WOS:000272113200005 ER PT J AU Dryer, PD Limketkai, BN Martin, CM Ma, G Sherman, KE Taylor, LE Mayer, KH Jamieson, DJ Blackard, JT AF Dryer, Peter D. Limketkai, Berkeley N. Martin, Christina M. Ma, Gang Sherman, Kenneth E. Taylor, Lynn E. Mayer, Kenneth H. Jamieson, Denise J. Blackard, Jason T. TI Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE HCV; NS5B; C316Y ID POLYMERASE INHIBITORS; UNTREATED PATIENTS; NONNUCLEOSIDE; PREVALENCE; NUCLEOSIDE; VARIANTS; PROTEASE; ANALOGS AB Objectives: Hepatitis C virus (HCV) non-nucleoside inhibitors (NNIs) target the viral RNA-dependent RNA polymerase encoded by the NS5B gene. Several NNIs share a similar allosteric binding site, and their antiviral efficacy is attenuated by a cysteine-to-tyrosine mutation at amino acid 316 (C316Y). In the current study, we assessed NS5B resistance mutations in treatment-naive individuals from a prospective natural history study of viral infections in women. Methods: Partial NS5B sequences from HCV-positive women were amplified by RT-PCR. Additionally, subcloning was performed to evaluate intrapatient variability in selected samples. Results: HCV NS5B genotypes were 45 genotype 1a (57.0%), 11 genotype 1b (13.9%), 5 genotype 2a (6.3%), 3 genotype 2b (3.8%), 9 genotype 3a (11.4%) and 6 genotype 4a (7.6%). One HCV genotype la-infected patient was found to have the C316Y mutation (1.3%). Clonal analysis further revealed that all NS5B sequences from this individual-representing three serum samples collected 4 years apart-contained the C316Y mutation. In contrast, the S282T resistance mutation was not found in any samples. Conclusions: The C316Y polymerase resistance mutation was found in 1.3% of samples from HCV-infected women. The presence of this mutation over time suggests significant replicative fitness of this variant and has implications for development of new specifically targeted antiviral therapies against HCV (STAT-C) targeting this region. C1 [Dryer, Peter D.; Limketkai, Berkeley N.; Martin, Christina M.; Ma, Gang; Sherman, Kenneth E.; Blackard, Jason T.] Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45221 USA. [Taylor, Lynn E.; Mayer, Kenneth H.] Brown Univ, Miriam Hosp, Providence, RI USA. [Taylor, Lynn E.; Mayer, Kenneth H.] Brown Univ, Dept Med, Providence, RI 02912 USA. [Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. RP Blackard, JT (reprint author), Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45221 USA. EM jason.blackard@uc.edu FU NIDA R21 [DA022148]; NIDDK K24 [DK 070528]; Brown University was funded by the CDC cooperative agreement [U64/CCU106795] FX This work was supported by an NIDA R21 (DA022148) award to J. T. B. and an NIDDK K24 (DK 070528) award to K. E. S. Data collection at Brown University was funded by the CDC cooperative agreement U64/CCU106795. NR 13 TC 6 Z9 6 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD NOV PY 2009 VL 64 IS 5 BP 945 EP 948 DI 10.1093/jac/dkp328 PG 4 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 516XZ UT WOS:000271578000008 PM 19767319 ER PT J AU Endimiani, A DePasquale, JM Forero, S Perez, F Hujer, AM Roberts-Pollack, D Fiorella, PD Pickens, N Kitchel, B Casiano-Colon, AE Tenover, FC Bonomo, RA AF Endimiani, Andrea DePasquale, John M. Forero, Sandra Perez, Federico Hujer, Andrea M. Roberts-Pollack, Daneshia Fiorella, Paul D. Pickens, Nancy Kitchel, Brandon Casiano-Colon, Aida E. Tenover, Fred C. Bonomo, Robert A. TI Emergence of bla(KPC)-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE LTCF; porins; carbapenemases; Enterobacteriaceae; outbreak ID CARBAPENEM-RESISTANT KLEBSIELLA; SPECTRUM BETA-LACTAMASES; IN-VITRO ACTIVITY; SEQUENCE TYPE 258; ESCHERICHIA-COLI; MOLECULAR EPIDEMIOLOGY; KPC CARBAPENEMASE; INFECTIONS; ENTEROBACTERIACEAE; FACILITIES AB Objectives: To characterize isolates of Klebsiella pneumoniae producing KPC carbapenemase (KPC-Kp) associated with an outbreak in a long-term acute care hospital (LTACH) in South Florida. Methods: During 21 March to 20 April 2008, 241 K. pneumoniae isolates detected at Integrated Regional Laboratories (Ft. Lauderdale, FL) for which the ertapenem MICs were >= 4 mg/L were studied. PCR, cloning and sequence analysis were used to detect bla(KPC) and to characterize the P-lactamase and outer membrane proteins (Omps). The expression level of KPC enzymes was studied by immunoblotting. Genetic relatedness of isolates was investigated with rep-PCR and PFGE. Clinical records of patients were investigated. Results: Seven KPC-Kp strains were isolated from different patients located at a single LTACH, with a further three isolates being recovered from patients at different hospitals. All KPC-Kp isolates in patients from the LTACH and from one hospital patient were genetically related and shared PFGE patterns that clustered with known sequence type (ST) 258 strains. These strains were highly resistant to carbapenems (MICs >= 32 mg/L) due to an increased level of KPC expression and loss of Omps. Rectal colonization was documented in all LTACH patients with KPC-Kp isolates. Treatment failures were common (crude mortality rate of 69%). Active surveillance and enhanced infection control practices terminated the KPC-Kp outbreak. Conclusions: The detection of KPC-Kp in an LTACH represents a serious infection control and therapeutic challenge in a new clinical setting. The speed at which the epidemic of KPC-Kp is spreading in our healthcare system mandates urgent action. C1 [Endimiani, Andrea; Perez, Federico; Hujer, Andrea M.; Bonomo, Robert A.] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH 44106 USA. [Endimiani, Andrea; Perez, Federico; Bonomo, Robert A.] Case Western Reserve Sch Med, Dept Med, Cleveland, OH 44106 USA. [DePasquale, John M.; Forero, Sandra; Roberts-Pollack, Daneshia; Fiorella, Paul D.; Pickens, Nancy] Florida Dept Hlth, Tallahassee, FL 32399 USA. [DePasquale, John M.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Tenover, Fred C.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Casiano-Colon, Aida E.] Integrated Reg Labs, Ft Lauderdale, FL 33309 USA. [Bonomo, Robert A.] Case Western Reserve Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA. [Bonomo, Robert A.] Case Western Reserve Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA. RP Bonomo, RA (reprint author), Dept Vet Affairs Med Ctr, 10701 E Blvd, Cleveland, OH 44106 USA. EM robert.bonomo@med.va.gov OI Endimiani, Andrea/0000-0003-3186-5421 FU NIAID NIH HHS [R03-AI081036, R01-AI063517] NR 45 TC 92 Z9 93 U1 1 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD NOV PY 2009 VL 64 IS 5 BP 1102 EP 1110 DI 10.1093/jac/dkp327 PG 9 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 516XZ UT WOS:000271578000032 PM 19740911 ER PT J AU Stanfill, SB Jia, LT Ashley, DL Watson, CH AF Stanfill, Stephen B. Jia, Lily T. Ashley, David L. Watson, Clifford H. TI Rapid and Chemically Selective Nicotine Quantification in Smokeless Tobacco Products using GC-MS SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID CHROMATOGRAPHY-MASS SPECTROMETRY; MOIST SNUFF; COTININE C1 [Stanfill, Stephen B.; Ashley, David L.; Watson, Clifford H.] Ctr Dis Control & Prevent, US Dept HHS, Natl Ctr Environm Hlth, Div Lab Sci,Emergency Response & Air Toxicants Br, Atlanta, GA 30341 USA. [Jia, Lily T.] Ctr Dis Control & Prevent, US Dept HHS, Natl Ctr Environm Hlth, Div Lab Sci,Organ Analyt Toxicol Branch 2, Atlanta, GA 30341 USA. RP Stanfill, SB (reprint author), Ctr Dis Control & Prevent, US Dept HHS, Natl Ctr Environm Hlth, Div Lab Sci,Emergency Response & Air Toxicants Br, Mailstop F-19,4770 Buford Highway NE, Atlanta, GA 30341 USA. NR 25 TC 15 Z9 15 U1 0 U2 14 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD NOV-DEC PY 2009 VL 47 IS 10 BP 902 EP 909 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 516FN UT WOS:000271527500011 PM 19930803 ER PT J AU Kuklenyik, Z Martin, A Pau, CP Holder, A Youngpairoj, AS Zheng, Q Cong, ME Garcia-Lerma, JG Heneine, W Pirkle, JL Barr, JR AF Kuklenyik, Zsuzsanna Martin, Amy Pau, Chou-Pong Holder, Angela Youngpairoj, Ae S. Zheng, Qi Cong, Mian-Er Garcia-Lerma, J. Gerardo Heneine, Walid Pirkle, James L. Barr, John R. TI On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Anion exchange; Ion-pair; Mass spectrometry; Liquid chromatography quadrupole; Metabolism; Metabolites; On-line analysis ID BLOOD MONONUCLEAR-CELLS; TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN-IMMUNODEFICIENCY-VIRUS; TENOFOVIR-DIPHOSPHATE; QUANTITATIVE-DETERMINATION; LAMIVUDINE TRIPHOSPHATE; CARBOVIR TRIPHOSPHATE; INFECTED PATIENTS; NUCLEOTIDES AB We developed an automated on-line weak anion exchange (WAX) solid-phase extraction (SPE) method coupled with ion-pair (IP) chromatography-tandem mass spectrometry (MS/MS) detection for quantitatively measuring triphosphorylated metabolites of three reverse transcriptase inhibitors (RTI). The administered pro-drugs were Tenofovir disoproxil fumarate (TDF), Emtricitabine (FTC) and Lamivudine (3TC). Their intracellular metabolites Tenofovir-diphosphate (TFV-DP), Emtricitabine-triphosphate (FTC-TP), and Lamivudine-triphosphate (3TC-TP) were measured in peripheral blood mononuclear cells (PBMC). We Coupled the WAX and IP chromatography systems using a combination of 6-port and 10-port switching valves, and we mixed the WAX elute with 1,5-dimethyl-hexyl-amine before IP chromatography separation. Multiple waste outlets allowed for eliminating potential matrix components interfering with MS/MS detection. Limits of detection were 9, 200 and 75 pg per sample for TFV-DP (448/176 m/z), FTC-TP (488/130 m/z) and 3TC-TP (468/119 m/z), respectively. (C) 2009 Published by Elsevier B.V. C1 [Kuklenyik, Zsuzsanna; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Martin, Amy; Pau, Chou-Pong; Holder, Angela; Youngpairoj, Ae S.; Zheng, Qi; Cong, Mian-Er; Garcia-Lerma, J. Gerardo; Heneine, Walid] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30341 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy,Mailstop F50, Atlanta, GA 30341 USA. EM jbarr@cdc.gov NR 31 TC 11 Z9 11 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD NOV 1 PY 2009 VL 877 IS 29 BP 3659 EP 3666 DI 10.1016/j.jchromb.2009.09.007 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 511MA UT WOS:000271168100026 PM 19783232 ER PT J AU Richardson-Harman, N Lackman-Smith, C Fletcher, PS Anton, PA Bremer, JW Dezzutti, CS Elliott, J Grivel, JC Guenthner, P Gupta, P Jones, M Lurain, NS Margolis, LB Mohan, S Ratner, D Reichelderfer, P Roberts, P Shattock, RJ Cummins, JE AF Richardson-Harman, Nicola Lackman-Smith, Carol Fletcher, Patricia S. Anton, Peter A. Bremer, James W. Dezzutti, Charlene S. Elliott, Julie Grivel, Jean-Charles Guenthner, Patricia Gupta, Phalguni Jones, Maureen Lurain, Nell S. Margolis, Leonid B. Mohan, Swarna Ratner, Deena Reichelderfer, Patricia Roberts, Paula Shattock, Robin J. Cummins, James E., Jr. TI Multisite Comparison of Anti-Human Immunodeficiency Virus Microbicide Activity in Explant Assays Using a Novel Endpoint Analysis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HUMAN CERVICAL TISSUE; ORGAN-CULTURE SYSTEM; TOPICAL MICROBICIDES; CANDIDATE MICROBICIDES; CXCR4-TROPIC HIV-1; TYPE-1 INFECTION; EX-VIVO; TRANSMISSION; CELLS; DISSEMINATION AB Microbicide candidates with promising in vitro activity are often advanced for evaluations using human primary tissue explants relevant to the in vivo mucosal transmission of human immunodeficiency virus type 1 (HIV-1), such as tonsil, cervical, or rectal tissue. To compare virus growth or the anti-HIV-1 efficacies of candidate microbicides in tissue explants, a novel soft-endpoint method was evaluated to provide a single, objective measurement of virus growth. The applicability of the soft endpoint is shown across several different ex vivo tissue types, with the method performed in different laboratories, and for a candidate microbicide (PRO 2000). The soft-endpoint method was compared to several other endpoint methods, including (i) the growth of virus on specific days after infection, (ii) the area under the virus growth curve, and (iii) the slope of the virus growth curve. Virus growth at the assay soft endpoint was compared between laboratories, methods, and experimental conditions, using nonparametric statistical analyses. Intra-assay variability determinations using the coefficient of variation demonstrated higher variability for virus growth in rectal explants. Significant virus inhibition by PRO 2000 and significant differences in the growth of certain primary HIV-1 isolates were observed by the majority of laboratories. These studies indicate that different laboratories can provide consistent measurements of anti-HIV-1 microbicide efficacy when (i) the soft endpoint or another standardized endpoint is used, (ii) drugs and/or virus reagents are centrally sourced, and (iii) the same explant tissue type and method are used. Application of the soft-endpoint method reduces the inherent variability in comparisons of preclinical assays used for microbicide development. C1 [Richardson-Harman, Nicola; Lackman-Smith, Carol; Jones, Maureen; Roberts, Paula; Cummins, James E., Jr.] So Res Inst, Microbicide Qual Assurance Program, Frederick, MD 21701 USA. [Fletcher, Patricia S.; Shattock, Robin J.] St Georges Univ London, Dept Cellular & Mol Med, Ctr Infect, London, England. [Anton, Peter A.; Elliott, Julie] Univ Calif Los Angeles, Ctr Prevent Res, Los Angeles, CA USA. [Bremer, James W.; Lurain, Nell S.] Rush Univ, Virol Qual Assurance Lab, Dept Immunol & Microbiol, Med Ctr, Chicago, IL 60612 USA. [Dezzutti, Charlene S.; Mohan, Swarna] Univ Pittsburgh, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA. [Grivel, Jean-Charles; Margolis, Leonid B.; Reichelderfer, Patricia] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Phys Biol, NIH, Bethesda, MD 20892 USA. [Guenthner, Patricia] Ctr Dis Control, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Gupta, Phalguni; Ratner, Deena] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA. RP Lackman-Smith, C (reprint author), So Res Inst, Microbicide Qual Assurance Program, 431 Aviat Way, Frederick, MD 21701 USA. EM lackmansmith@southernresearch.org FU Microbicide Quality Assurance Program (MQAP); U. S. National Institutes of Health [NICHDN01-HD-3-3350]; NIAID [N01-AI-33350]; St. George's, University of London, London, United Kingdom (DFID/MRD); Magee-Womens Research Institute; University of Pittsburgh,; NIH [U01 AI068633-07]; NIH CFAR Mucosal Immunology Core [AI 28997]; NIH IP/CP U19 [AI 060614] FX Investigators using explant assays in their respective microbicide-related research were invited to participate in the design of the studies described in this paper. Technical staff participated in regular conference calls and discussions of the standardized procedures as the studies were implemented and data were acquired. The author list includes the principal investigators from the participating laboratories and their respective technical representatives. Since participation in the MQAP was voluntary, it should be noted that the explant studies described in this paper were facilitated by the infrastructure, resources, and microbicide-related grant support available at each of the following participating laboratories (this order does not correspond to the randomly assigned lab identification letters): National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (NIH Intramural Program); Rush University Medical Center, Department of Immunology/Microbiology, Chicago, IL (Virology Quality Assurance [VQA] Program supported by NIAID grant N01-AI-50044); St. George's, University of London, London, United Kingdom (DFID/MRD to R. J. S. as part of the Microbicide Development Programme); Magee-Womens Research Institute, University of Pittsburgh, School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Pittsburgh, PA (NIH grant U01 AI068633-07 to C. S. D.); and Center for Prevention Research at David Geffen School of Medicine, University of California-Los Angeles AIDS Institute (NIH CFAR Mucosal Immunology Core grant AI 28997 and NIH IP/CP U19 grant AI 060614 to P. A. A.). NR 34 TC 24 Z9 25 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2009 VL 47 IS 11 BP 3530 EP 3539 DI 10.1128/JCM.00673-09 PG 10 WC Microbiology SC Microbiology GA 514CZ UT WOS:000271373000023 PM 19726602 ER PT J AU Gelting, R AF Gelting, Rick TI Water Safety Plans: CDC's Role SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material C1 CDC, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Environm Hlth Serv Branch, Atlanta, GA 30341 USA. RP Gelting, R (reprint author), CDC, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Environm Hlth Serv Branch, 4770 Buford Highway,NE MS F-60, Atlanta, GA 30341 USA. EM rgelting@cdc.gov NR 0 TC 2 Z9 2 U1 0 U2 2 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD NOV PY 2009 VL 72 IS 4 BP 44 EP 45 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 515TB UT WOS:000271494700008 PM 19908438 ER PT J AU Welte, T Reagan, K Fang, H Machain-Williams, C Zheng, X Mendell, N Chang, GJJ Wu, P Blair, CD Wang, T AF Welte, Thomas Reagan, Krystle Fang, Hao Machain-Williams, Carlos Zheng, Xin Mendell, Nicole Chang, Gwong-Jen J. Wu, Ping Blair, Carol D. Wang, Tian TI Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID DELTA T-CELLS; SPLENIC DENDRITIC CELLS; MURINE LANGERHANS CELLS; TUMOR-NECROSIS-FACTOR; DOUBLE-STRANDED-RNA; B-CELLS; IN-VITRO; CLASS-II; ENCEPHALITIS; RECOGNITION AB The Toll-like receptor (TLR) 7 response represents a vital host-defence mechanism in a murine model of systemic West Nile virus (WNV) infection. Here, we investigated the role of the TLR7-induced immune response following cutaneous WNV infection. We found that there was no difference in susceptibility to WNV encephalitis between wild-type and TLR7(-/-) mice upon intradermal injection or infected mosquito feeding. Viral load analysis revealed similar levels of WNV RNA in the peripheral tissues and brains of these two groups of mice following intradermal infection. There was a higher level of cytokines in the blood of wild-type mice at early stages of infection; however, this difference was diminished in the blood and brains at later stages. Langerhans cells (LCs) are permissive to WNV infection and migrate from the skin to draining lymph nodes upon intradermal challenge. Our data showed that WNV infection of TLR7(-/-) keratinocytes was significantly higher than that of wild-type keratinocytes. Infection of wild-type keratinocytes induced higher levels of alpha interferon and interleukin-1 beta (IL-1 beta), IL-6 and IL-12, which might promote LC migration from the skin. Co-culture of naive LCs of wild-type mice with WNV-infected wild-type keratinocytes resulted in the production of more IL-6 and IL-12 than with TLR7(-/-) keratinocytes or by cultured LCs alone. Moreover, LCs in the epidermis were reduced in wild-type mice, but not in TLR7(-/-) mice, following intradermal WNV infection. Overall, our results suggest that the TLR7 response following cutaneous infection promotes LC migration from the skin, which might compromise its protective effect in systemic infection. C1 [Welte, Thomas; Fang, Hao; Mendell, Nicole; Wang, Tian] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Welte, Thomas; Fang, Hao; Mendell, Nicole; Wang, Tian] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Reagan, Krystle; Machain-Williams, Carlos; Zheng, Xin; Blair, Carol D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Wu, Ping] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA. RP Wang, T (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. EM ti1wang@utmb.edu FU NIH [R01AI072060, R03AI067409, N01AI25489]; Centers for Disease Control and Prevention [T01/CCT822307] FX This work was supported by NIH grants R01AI072060 (to T. W.), R03AI067409 (to T. W.) and contract N01AI25489 (subcontract to C. D. B.; R. Tesh, Principal Investigator). K. R. was supported by the Fellowship Training Program (T01/CCT822307) from the Centers for Disease Control and Prevention. We thank Regeneron Inc. and Dr Richard Flavell (Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA) for providing TLR7-/- mice. We also thank Matt Whitney and Shaobin Shang for technical help and Mardelle Susman for assisting in manuscript preparation. NR 53 TC 45 Z9 49 U1 1 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD NOV PY 2009 VL 90 BP 2660 EP 2668 DI 10.1099/vir.0.011783-0 PG 9 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 515BF UT WOS:000271440500011 PM 19641044 ER PT J AU Redwood, D Joseph, DA Christensen, C Provost, E Peterson, VL Espey, D Sacco, F AF Redwood, Diana Joseph, Djenaba A. Christensen, Claudia Provost, Ellen Peterson, V. Lynn Espey, David Sacco, Frank TI Development of a Flexible Sigmoidoscopy Training Program for Rural Nurse Practitioners and Physician Assistants to Increase Colorectal Cancer Screening among Alaska Native People SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Colorectal cancer screening; Alaska Native people; flexible sigmoidoscopy; training curriculum ID HELICOBACTER-PYLORI; TASK-FORCE; ENDOSCOPISTS; POPULATION; ADULTS AB At the Alaska Native Medical Center in Anchorage, colorectal cancer screening rates improved dramatically with the initiation of a dedicated flexible sigmoidoscopy screening program staffed by mid-level providers. We describe the development and implementation of a program to train rural nurse practitioners and physician assistants in flexible sigmoidoscopy. C1 [Redwood, Diana; Provost, Ellen] ANTHC, Alaska Native Epidemiol Ctr, Anchorage, AK 99508 USA. [Joseph, Djenaba A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Christensen, Claudia; Sacco, Frank] ANTHC, Alaska Native Med Ctr, Anchorage, AK 99508 USA. [Espey, David] CDC, Div Canc Prevent & Control, Indian Hlth Serv, Atlanta, GA 30333 USA. RP Redwood, D (reprint author), ANTHC, Alaska Native Epidemiol Ctr, 4000 Ambassador Dr, Anchorage, AK 99508 USA. EM dredwood@anthc.org NR 22 TC 9 Z9 9 U1 0 U2 1 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD NOV PY 2009 VL 20 IS 4 BP 1041 EP 1048 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 519IK UT WOS:000271759100012 PM 20168016 ER PT J AU McMahon, BJ Dentinger, CM Bruden, D Zanis, C Peters, H Hurlburt, D Bulkow, L Fiore, AE Bell, BP Hennessy, TW AF McMahon, Brian J. Dentinger, Catherine M. Bruden, Dana Zanis, Carolyn Peters, Helen Hurlburt, Debbie Bulkow, Lisa Fiore, Anthony E. Bell, Beth P. Hennessy, Thomas W. TI Antibody Levels and Protection after Hepatitis B Vaccine: Results of a 22-Year Follow-Up Study and Response to a Booster Dose SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID YUPIK ESKIMO POPULATION; HEALTH-CARE WORKERS; GENOTYPE-F; CHILDREN; EFFICACY; IMMUNITY; VIRUS; PERSISTENCE; TRIAL; IMMUNOGENICITY AB Background. The duration of protection in children and adults (including health care workers) resulting from the hepatitis B vaccine primary series is unknown. Methods. To determine the protection afforded by hepatitis B vaccine, Alaska Native persons who had received plasma-derived hepatitis B vaccine when they were > 6 months of age were tested for antibody to hepatitis B surface antigen (anti-HBs) 22 years later. Those with levels < 10 mIU/mL received 1 dose of recombinant hepatitis B vaccine and were evaluated on the basis of anti-HBs measurements at 10-14 days, 30-60 days, and 1 year. Results. Of 493 participants, 60% (298) had an anti-HBs level >= 10 mIU/mL. A booster dose was administered to 164 persons, and 77% responded with an anti-HBs level >= 10 mIU/mL at 10-14 days, reaching 81% by 60 days. Response to a booster dose was positively correlated with younger age, peak anti-HBs response after primary vaccination, and the presence of detectable anti-HBs before boosting. Considering persons with an anti-HBs level >= 10 mIU/mL at 22 years and those who responded to the booster dose, protection was demonstrated in 87% of the participants. No new acute or chronic hepatitis B virus infections were identified. Conclusions. The protection afforded by primary immunization with plasma-derived hepatitis B vaccine during childhood and adulthood lasts at least 22 years. Booster doses are not needed. C1 [McMahon, Brian J.] Ctr Dis Control & Prevent CDC, Liver Dis & Hepatitis Program, Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [McMahon, Brian J.; Dentinger, Catherine M.; Bruden, Dana; Zanis, Carolyn; Peters, Helen; Hurlburt, Debbie; Bulkow, Lisa; Hennessy, Thomas W.] Ctr Dis Control & Prevent CDC, Arct Invest Program, Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA. [Fiore, Anthony E.; Bell, Beth P.] CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP McMahon, BJ (reprint author), Alaska Native Med Ctr, Liver Dis & Hepatitis Program, 4315 Diplomacy Dr, Anchorage, AK 99508 USA. EM bdm9@cdc.gov FU Centers for Disease Control and Prevention [U50/CCU022279]; Alaska Native Tribal Health Consortium [U50/CCU022279] FX Financial support: This study was funded in part through a cooperative agreement (U50/CCU022279) between the Centers for Disease Control and Prevention and the Alaska Native Tribal Health Consortium. NR 25 TC 102 Z9 111 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 IS 9 BP 1390 EP 1396 DI 10.1086/606119 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504XY UT WOS:000270652800006 PM 19785526 ER PT J AU Al Awaidy, SA Bawikar, S Al Busaidy, S Baqiani, S Al Abedani, I Varghese, R Abdoan, HS Al Abdoon, H Bhatnagar, S Al Hasini, KS Mohan, P Shah, S Elamir, E Klena, J Ahmed, SF Teleb, N Parashar, U Patel, MM AF Al Awaidy, S. A. Bawikar, S. Al Busaidy, S. Baqiani, S. Al Abedani, I. Varghese, R. Abdoan, H. S. Al Abdoon, H. Bhatnagar, S. Al Hasini, K. S. Mohan, P. Shah, S. Elamir, E. Klena, J. Ahmed, S. F. Teleb, N. Parashar, U. Patel, M. M. TI Considerations for Introduction of a Rotavirus Vaccine in Oman: Rotavirus Disease and Economic Burden SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GASTROENTERITIS; EFFICACY; SAFETY AB Rotavirus is the most common cause of fatal childhood diarrhea worldwide. We provide the first estimates of the health care and economic burden of severe rotavirus disease in Oman. We conducted active, hospital-based surveillance of rotavirus disease at 11 regional public hospitals in Oman, using the guidelines suggested by the generic World Health Organization protocol. From July 2006 through June 2008, all children aged <5 years who were hospitalized for acute gastroenteritis were enrolled in the surveillance program, and their stool samples were tested for rotavirus using a commercially available enzyme immunoassay (ID EIA Rotavirus Test; Dako Diagnostics). Rotavirus was detected in samples from 1712 (49%) of 3470 children. These children were hospitalized for a median of 3 days for severe diarrhea. A marked seasonal peak was evident with a majority of the cases occurring from December through May. Of the rotavirus cases, 69% occurred in children aged 6-17 months. We identified a diverse strain pattern in Oman, with G2 (37%), G1 (38%), and G9 (11%) accounting for most of typeable strains. By our burden estimates, the Omani government spends an estimated US$791,817 and US$1.8 million annually to treat rotavirus-associated diarrhea in the outpatient and hospital settings, respectively. A rotavirus vaccination program might substantially reduce the burden of severe diarrhea among children in Oman. C1 [Parashar, U.; Patel, M. M.] Ctr Dis Control & Prevent, Enter Viruses Team, Atlanta, GA 30333 USA. [Al Awaidy, S. A.; Bawikar, S.; Al Abedani, I.; Al Hasini, K. S.; Mohan, P.; Shah, S.; Elamir, E.] Dept Communicable Dis Surveillance & Control, Muscat, Oman. [Al Busaidy, S.; Baqiani, S.; Varghese, R.] Dept Cent Publ Hlth Lab, Muscat, Oman. [Abdoan, H. S.; Al Abdoon, H.] Sultan Qaboos Univ, Muscat, Oman. [Bhatnagar, S.] Royal Hosp, Muscat, Oman. [Klena, J.; Ahmed, S. F.] US Naval Med Res Univ Number 3, Cairo, Egypt. [Teleb, N.] World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt. RP Patel, MM (reprint author), Ctr Dis Control & Prevent, Enter Viruses Team, MS-A47,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM Aul3@cdc.gov RI Valle, Ruben/A-7512-2013 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 15 TC 14 Z9 14 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S248 EP S253 DI 10.1086/605339 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100028 PM 19817605 ER PT J AU Arvay, ML Curns, AT Terp, S Armah, G Wontuo, P Parashar, UD Binka, F Glass, RI Widdowson, MA AF Arvay, Melissa L. Curns, Aaron T. Terp, Sophia Armah, George Wontuo, Peter Parashar, Umesh D. Binka, Fred Glass, Roger I. Widdowson, Marc-Alain TI How Much Could Rotavirus Vaccines Reduce Diarrhea-Associated Mortality in Northern Ghana? A Model to Assess Impact SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID COST-EFFECTIVENESS; RISK-FACTORS; VACCINATION; EFFICACY; CHILDREN; SAFETY AB Background. Effective rotavirus vaccines could substantially reduce the similar to 500,000 deaths due to rotavirus disease per year worldwide, although the impact will depend on vaccine effectiveness, timing of administration, and coverage. We modeled vaccine impact on rotavirus-associated mortality in rural Ghana. Methods. All deaths due to acute diarrhea among children during 1998-2004 in the Kassena-Nankana District of Ghana were identified, and the number of deaths due to rotavirus disease was estimated using hospital laboratory surveillance data. Assuming rotavirus vaccine would be included in the current Expanded Program on Immunization schedule, we estimated the reduction in rotavirus-associated mortality with use of the current coverage and timing of diphtheria, tetanus, and pertussis vaccine administration and various age-restricted schedules. Results. Of the 381 deaths due to diarrhea, 131 (34%) were estimated to be caused by rotavirus infection. On the basis of current diphtheria, tetanus, and pertussis vaccine coverage and timing, a 90% efficacious 3-dose rotavirus vaccine would prevent 70% of deaths due to rotavirus infection if administered without age restrictions, 53% if only initiated among children <12 weeks of age, and 52% if the course also was completed by 32 weeks of age. Conclusions. Rotavirus vaccine has the potential to substantially reduce rotavirus-associated mortality in rural Ghana. Although timely vaccination should be encouraged, extending the current age recommendation for initiation of rotavirus vaccination could increase the coverage and impact of vaccination. C1 [Arvay, Melissa L.; Curns, Aaron T.; Parashar, Umesh D.; Widdowson, Marc-Alain] Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, Atlanta, GA 30030 USA. [Terp, Sophia] Ctr Dis Control & Prevent Fdn, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Binka, Fred] Univ Ghana, Sch Publ Hlth, Accra, Ghana. [Armah, George] Univ Ghana, Legon, Ghana. [Wontuo, Peter] Navrongo Hlth Res Ctr, Navrongo, Ghana. RP Arvay, ML (reprint author), Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS C-12, Atlanta, GA 30030 USA. EM MArvay@cdc.gov OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU O. C. Hubert Fellowship; Centers for Disease Control and Prevention Foundation; GAVI Alliance FX Financial support: O. C. Hubert Fellowship, Centers for Disease Control and Prevention Foundation, and the GAVI Alliance (through PATH). NR 24 TC 11 Z9 12 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S85 EP S91 DI 10.1086/605062 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100011 PM 19817619 ER PT J AU Atherly, D Dreibelbis, R Parashar, UD Levin, C Wecker, J Rheingans, RD AF Atherly, Deborah Dreibelbis, Robert Parashar, Umesh D. Levin, Carol Wecker, John Rheingans, Richard D. TI Rotavirus Vaccination: Cost-Effectiveness and Impact on Child Mortality in Developing Countries SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SENTINEL HOSPITAL SURVEILLANCE; UPPER RIVER DIVISION; 8 LATIN-AMERICAN; DISEASE BURDEN; DIARRHEAL DISEASE; EPIDEMIOLOGIC FEATURES; HONG-KONG; IMMUNIZATION PROGRAM; CARIBBEAN COUNTRIES; UNITED-STATES AB Background. Rotavirus is the leading cause of severe gastroenteritis in children <5 years of age and is responsible for >500,000 deaths annually; similar to 85% of this burden is in low-income countries eligible for financial support from the GAVI Alliance. We projected the uptake, health impact, and cost-effectiveness of introducing rotavirus vaccination in GAVI-eligible countries to help policy makers in prioritizing resources to gain the greatest health improvements for their constituencies. Methods. A demand forecast model was used to predict adoption of rotavirus vaccine in the poorest countries in the world. We then modeled health outcomes and direct costs of a hypothetical birth cohort in the target population for scenarios with and without a rotavirus vaccine with use of data on health outcomes of rotavirus infection, vaccine effectiveness, and immunization rates. Results. Vaccination would prevent 2.4 million rotavirus deaths and >82 million disability-adjusted life-years (DALYs) in 64 of the 72 GAVI-eligible countries introducing vaccine from 2007 through 2025. The cost per DALY averted decreases over time, from a high of US$450 per DALY averted in the first year to a sustained low of $30 per DALY during 2017-2025, with a cumulative figure of $43 per DALY averted during 2008-2025. By applying the baseline scenario with an initial vaccine price of $7 per dose for a 2-dose vaccine, with a gradual decrease beginning in 2012 and stabilizing at $1.25 per dose by 2017, vaccination was very cost-effective in all GAVI-eligible countries with use of each country's gross domestic product per DALY averted as a threshold. Conclusions. Introduction of rotavirus vaccines into the world's poorest countries is very cost-effective and is projected to substantially reduce childhood mortality. C1 [Atherly, Deborah; Levin, Carol; Wecker, John] PATH, Seattle, WA 98107 USA. [Dreibelbis, Robert; Rheingans, Richard D.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Parashar, Umesh D.] Ctr Dis Control & Prevent, Viral Enter Epidemiol Team, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Atherly, D (reprint author), PATH, 1455 NW Leary Way, Seattle, WA 98107 USA. EM datherly@path.org OI Dreibelbis, Robert/0000-0002-9716-0419 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 81 TC 42 Z9 44 U1 1 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S28 EP S38 DI 10.1086/605033 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100004 PM 19817610 ER PT J AU Bahl, R Saxena, M Bhandari, N Taneja, S Mathur, M Parashar, UD Gentsch, J Shieh, WJ Zaki, SR Glass, R Bhan, MK AF Bahl, Rajiv Saxena, Manju Bhandari, Nita Taneja, Sunita Mathur, Meera Parashar, Umesh D. Gentsch, Jon Shieh, Wun-Ju Zaki, Sherif R. Glass, Roger Bhan, Maharaj K. CA Delhi Intussusception Study Hosp G TI Population-Based Incidence of Intussusception and a Case-Control Study to Examine the Association of Intussusception with Natural Rotavirus Infection among Indian Children SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ADENOVIRUS INFECTION; YOUNG-CHILDREN; UNITED-STATES; FEBRUARY 1; VACCINE; INFANTS; CHILDHOOD; DIARRHEA; HOSPITALIZATION; EPIDEMIOLOGY AB Background. A rotavirus vaccine previously licensed in the United States was withdrawn because it caused intussusception. Data on background intussusception rates in developing countries are required to plan pre- and postlicensure safety studies for new rotavirus vaccines. Also, it is unclear whether natural rotavirus infection is associated with intussusception. Methods. Passive surveillance for intussusception in a large, well-defined, poor, urban population in Delhi, India, was conducted in 2 phases. Intussusception was confirmed by ultrasonography or surgery. Fecal samples obtained from patients with intussusception at study hospitals (irrespective of their residence in study areas) and healthy control subjects were tested for rotavirus with use of enzyme immunoassay. If available, resected intestinal tissue samples were tested for rotavirus with use of immunohistochemistical analysis and reverse-transcription polymerase chain reaction. Results. The incidence of intussusception requiring hospitalization was 17.7 cases per 100,000 infant-years of follow-up (95% confidence interval, 5.9-41.4 cases per 100,000 infant-years). Detection rates of rotavirus in stool samples did not differ significantly between case patients and control subjects (4 of 42 case patients vs 6 of 92 control subjects), and no evidence of rotavirus was detected in any of the 22 patients with intussusception for whom intestinal tissue samples were available. Conclusions. The incidence of intussusception among Indian infants appears to be lower than that reported in other middle-and high-income countries. Natural rotavirus infection does not appear to be a major cause of intussusception in Indian infants. C1 [Bhan, Maharaj K.] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India. [Parashar, Umesh D.; Gentsch, Jon; Shieh, Wun-Ju; Zaki, Sherif R.; Glass, Roger] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Bhan, MK (reprint author), All India Inst Med Sci, Dept Pediat, New Delhi 110029, India. EM community.research@cih.uib.no FU Department of Vaccines and Biologicals, World Health Organization; GAVI Alliance FX Financial support: Department of Vaccines and Biologicals, World Health Organization.; Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 40 TC 13 Z9 13 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S277 EP S281 DI 10.1086/605045 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100032 PM 19817609 ER PT J AU Benhafid, M Youbi, M Klena, JD Gentsch, JR Teleb, N Widdowson, MA ElAouad, R AF Benhafid, Mohammed Youbi, Mohammed Klena, John D. Gentsch, Jon R. Teleb, Nadia Widdowson, Marc-Alain ElAouad, Rajae TI Epidemiology of Rotavirus Gastroenteritis among Children < 5 Years of Age in Morocco during 1 Year of Sentinel Hospital Surveillance, June 2006-May 2007 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GROUP-A ROTAVIRUS; POLYMERASE CHAIN-REACTION; GLOBAL DISTRIBUTION; MIXED INFECTIONS; HIGH-FREQUENCY; STRAINS; G9; EMERGENCE; DISEASE; DIVERSITY AB Background. In anticipation of vaccine introduction, we assessed the epidemiology, burden, and genotype of infecting strains of rotavirus disease among Moroccan children hospitalized for acute gastroenteritis. Methods. From June 2006 through May 2007, 345 children <5 years of age who had acute gastroenteritis and were admitted to 4 sentinel hospitals in different regions of Morocco were enrolled in this surveillance study, and stool specimens were tested for the presence of rotavirus with use of enzyme immunoassay. RNA from positive samples was genotyped by reverse-transcriptase polymerase chain reaction. Results. Overall, 314 children had complete data available, and among these, 138 (44%) tested positive for rotavirus. Rotavirus infection was most common among children <24 months of age (95% of all hospitalizations for rotavirus infection). Rotavirus infection was detected year-round at all 4 sites but was most prevalent from September through January. Genotype analysis demonstrated that 30.6% of samples were G1[P8], 26% were G9[P8], 7.5% were G2[P6], 3.7% were G1[P6], and 0.7% were G2[P8]. Nucleotide sequencing analysis of G- or P-untypeable strains showed that 4.5% were G9[P8], 2.2% were G1[8], 2.2% were G2[P6], and 1.5% were G2[P4]. A high frequency of mixed infection (21%) was found, of which G1G2[P8] accounted for the majority (16.4%). Conclusions. Rotavirus was responsible for 44% of all hospitalizations for diarrhea among young children at these 4 separate sites in Morocco. These data will help inform a decision on the introduction of rotavirus vaccine in Morocco. Continued and extended surveillance in Morocco will be important to monitor changes in the epidemiology of rotavirus disease and the impact of vaccination after introduction. C1 [Benhafid, Mohammed; ElAouad, Rajae] Natl Inst Hyg, Virol Lab, Rabat 10000, Morocco. [Youbi, Mohammed] Minist Hlth, Epidemiol & Dis Control Dept, Rabat, Morocco. [Teleb, Nadia] Reg Off Eastern Mediterranean, World Hlth Org, Cairo, Egypt. [Gentsch, Jon R.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Viral Gastroenteritis Unit, Atlanta, GA USA. RP Benhafid, M (reprint author), Natl Inst Hyg, Virol Lab, 27 Rue Ibn Batouta, Rabat 10000, Morocco. EM benhafidm@yahoo.fr OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU World Health Organization; PATH FX Financial support: World Health Organization and PATH. NR 32 TC 12 Z9 12 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S70 EP S75 DI 10.1086/605048 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100009 PM 19817617 ER PT J AU Bines, JE Patel, M Parashar, U AF Bines, Julie E. Patel, Manish Parashar, Umesh TI Assessment of Postlicensure Safety of Rotavirus Vaccines, with Emphasis on Intussusception SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID EVENT REPORTING SYSTEM; YOUNG-CHILDREN; REVERSE TRANSCRIPTION; VACCINATION PROGRAM; CEREBROSPINAL-FLUID; EARLY-CHILDHOOD; CASE-DEFINITION; US INFANTS; INFECTION; GASTROENTERITIS AB The global implementation of rotavirus vaccines will result in a major step toward limiting the disease burden of rotavirus infection. However, as history has shown with the experience of Rotashield (Wyeth Lederle Vaccines), the introduction of a new vaccine should occur in parallel with a postmarketing surveillance strategy to detect any unexpected or rare adverse events. Two new rotavirus vaccines (Rotarix [GSK Biologicals] and RotaTeq [Merck]) have been found to be safe and effective in large clinical trials involving >60,000 infants in the Americas and Europe. However, given that intussusception is an extremely rare event, some risk could be detected as the vaccine is administered to a larger number of infants. In response to a recommendation of the World Health Organization Global Advisory Committee for Vaccine Safety, a standardized approach to the postmarketing surveillance of rotavirus vaccine safety has been developed. We review the principal safety issues requiring further evaluation in postlicensure use of rotavirus vaccines. For intussusception, we also discuss challenges and approaches to monitoring. C1 [Bines, Julie E.] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia. [Bines, Julie E.] Royal Childrens Hosp, Melbourne, Vic, Australia. [Bines, Julie E.] Murdoch Childrens Res Inst, Melbourne, Vic, Australia. [Patel, Manish; Parashar, Umesh] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. RP Bines, JE (reprint author), Univ Melbourne, Dept Paediat, Flemington Rd, Parkville, Vic 3052, Australia. EM julie.bines@rch.org.au FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 78 TC 28 Z9 28 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S282 EP S290 DI 10.1086/605051 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100033 PM 19817611 ER PT J AU Carlos, CC Inobaya, MT Bresee, JS Lagrada, ML Olorosa, AM Kirkwood, CD Widdowson, MA AF Carlos, Celia C. Inobaya, Marianette T. Bresee, Joseph S. Lagrada, Marietta L. Olorosa, Agnettah M. Kirkwood, Carl D. Widdowson, Marc-Alain TI The Burden of Hospitalizations and Clinic Visits for Rotavirus Disease in Children Aged < 5 Years in the Philippines SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID COST-EFFECTIVENESS; DIARRHEAL DISEASE; UNITED-STATES; SURVEILLANCE; GASTROENTERITIS; VACCINATION; INFECTION; EFFICACY; SAFETY AB Background. Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines. Methods. From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets. Results. The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8]. Conclusions. The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden. C1 [Carlos, Celia C.; Lagrada, Marietta L.; Olorosa, Agnettah M.] Res Inst Trop Med, Antimicrobial Resistance Surveillance Reference L, Dept Hlth, Muntinlupa, Metro Manila, Philippines. [Inobaya, Marianette T.] Res Inst Trop Med, Dept Epidemiol & Biostat, Dept Hlth, Muntinlupa, Metro Manila, Philippines. [Bresee, Joseph S.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Kirkwood, Carl D.] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia. RP Carlos, CC (reprint author), Res Inst Trop Med, Antimicrobial Resistance Surveillance Reference L, Dept Hlth, Muntinlupa, Metro Manila, Philippines. EM ccarlos@ritm.gov.ph OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU PATH; GAVI Alliance FX Financial support: PATH, funded in full or in part by the GAVI Alliance. NR 31 TC 11 Z9 12 U1 1 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S174 EP S181 DI 10.1086/605044 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100021 PM 19817598 ER PT J AU Cortese, MM Staat, MA Weinberg, GA Edwards, K Rice, MA Szilagyi, PG Hall, CB Payne, DC Parashar, UD AF Cortese, Margaret M. Staat, Mary Allen Weinberg, Geoffrey A. Edwards, Kathryn Rice, Marilyn A. Szilagyi, Peter G. Hall, Caroline B. Payne, Daniel C. Parashar, Umesh D. TI Underestimates of Intussusception Rates among US Infants Based on Inpatient Discharge Data: Implications for Monitoring the Safety of Rotavirus Vaccines SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNIZATION PRACTICES ACIP; ADVISORY-COMMITTEE; CHILDREN; GASTROENTERITIS; VACCINATION; HOSPITALIZATIONS; RECOMMENDATIONS; PREVENTION; EFFICACY; TRENDS AB Background. Because a previous rotavirus vaccine was associated with intussusception, new rotavirus vaccines are monitored postlicensure for any such association. Accurate background intussusception rates are needed to determine whether the number of cases observed after vaccination exceeds that expected by chance. Previously, intussusception rates were obtained from inpatient discharge databases. We sought to determine the rate of intussusception among infants managed only with short-stay or emergency department care. Methods. Intussusception cases occurring in infants were identified retrospectively at 3 children's hospitals from January 2001 through March 2006, a period without rotavirus vaccine use, by a search of discharge, billing, and radiology databases for International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0 (intussusception) and procedure codes and by review of medical records. Results. Of 156 infants with intussusception fulfilling Brighton level 1 criteria, 81 (52%) were billed as inpatients, 68 (44%) as short-stay patients, and 7 (4%) as emergency department patients only. The use of only inpatients assigned code 560.0 underestimated the total number of level 1 cases at the hospitals by 44%. The mean annual intussusception rate for the hospitals' catchment counties was 49.3 cases per 100,000 live births (inpatient cases: 27.1 cases per 100,000 live births; short-stay or emergency department cases: 22.3 cases per 100,000 live births). Conclusions. Intussusception rates based solely on inpatient discharge databases could underestimate the true incidence of level 1 intussusception by >40%. Background rates used for assessment of risk after vaccination should account for cases managed only with short-stay or emergency department care. C1 [Cortese, Margaret M.; Payne, Daniel C.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Staat, Mary Allen; Rice, Marilyn A.] Univ Cincinnati, Med Ctr, Coll Med, Cincinnati Childrens Hosp,Dept Pediat, Cincinnati, OH 45267 USA. [Weinberg, Geoffrey A.; Szilagyi, Peter G.; Hall, Caroline B.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA. [Edwards, Kathryn] Vanderbilt Univ, Med Ctr, Dept Pediat, Vanderbilt Vaccine Res Program, Nashville, TN 37232 USA. RP Cortese, MM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS-A47, Atlanta, GA 30333 USA. EM mcortese@cdc.gov FU National Vaccine Program Office; GAVI Alliance FX Financial support: National Vaccine Program Office.; Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 17 TC 20 Z9 20 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S264 EP S270 DI 10.1086/605055 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100030 PM 19817607 ER PT J AU Curns, AT Coffin, F Glasser, JW Glass, RI Parashar, UD AF Curns, Aaron T. Coffin, Fanny Glasser, John W. Glass, Roger I. Parashar, Umesh D. TI Projected Impact of the New Rotavirus Vaccination Program on Hospitalizations for Gastroenteritis and Rotavirus Disease among US Children < 5 Years of Age during 2006-2015 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNIZATION PRACTICES ACIP; UNITED-STATES; VARICELLA VACCINATION; ADVISORY-COMMITTEE; DIARRHEA; SURVEILLANCE; TRENDS; PREVENTION; MORBIDITY; MORTALITY AB Background. Rotavirus causes approximately one-third to one-half (55,000-70,000 hospitalizations per year) of hospitalizations for acute gastroenteritis (AGE) among US children <5 years of age. We forecasted the potential reduction in the number of hospitalizations for rotavirus disease and AGE in US children during 2006-2015 as a result of the new rotavirus vaccine introduced in 2006. Methods. The mean number of hospitalizations for AGE by calendar month among US children was determined using the National Hospital Discharge Survey from the period 1993-2005. From these baseline prevaccine estimates, we forecasted the effect of vaccine in reducing the number of hospitalizations for rotavirus disease and AGE during 2006-2015 with use of estimates of vaccine effectiveness and uptake. Results. During 2006-2015, similar to 313,000 (45%) of an estimated 703,190 hospitalizations for rotavirus disease would be directly prevented by vaccination. A significant reduction in the number of hospitalizations for AGE should be detectable among infants aged 0-11 months during the first quarter of 2009, followed by children aged 12-23 months during 2010, and all children <5 years of age during 2011. Conclusions. Vaccination is expected to substantially reduce the health burden of hospitalizations for rotavirus disease among US children during 2006-2015, and the impact of vaccination based on direct protective effects alone was expected to first occur for hospitalizations for AGE among infants during winter 2009. C1 [Curns, Aaron T.; Glasser, John W.; Glass, Roger I.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Coffin, Fanny] Inst Curie, Paris, France. [Coffin, Fanny] Inst Natl Sante & Rech Med, U900, Paris, France. [Coffin, Fanny] ParisTech, Fontainebleau, France. RP Curns, AT (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS A47, Atlanta, GA 30329 USA. EM agc8@cdc.gov FU Centers for Disease Control and Prevention FX Financial support: Centers for Disease Control and Prevention. NR 28 TC 10 Z9 10 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S49 EP S56 DI 10.1086/605036 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100006 PM 19817614 ER PT J AU Duan, ZJ Liu, N Yang, SH Zhang, J Sun, LW Tang, JY Jin, Y Du, ZQ Xu, J Wu, QB Tong, ZL Gong, ST Qian, Y Ma, JM Liao, XC Widdowson, MA Jiang, BM Fang, ZY AF Duan, Zhao-jun Liu, Na Yang, Su-hua Zhang, Jing Sun, Li-Wei Tang, Jing-Yu Jin, Yu Du, Zeng-Qing Xu, Jin Wu, Qing-bin Tong, Zhi-li Gong, Si-tang Qian, Yuan Ma, Jian-min Liao, Xu-chun Widdowson, Marc-Alain Jiang, Baoming Fang, Zhao-Yin TI Hospital-Based Surveillance of Rotavirus Diarrhea in the People's Republic of China, August 2003-July 2007 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GROUP-A ROTAVIRUS; ACUTE GASTROENTERITIS; CHILDREN; EPIDEMIOLOGY; DISEASE AB Rotaviruses cause acute diarrhea worldwide. Previous studies of rotavirus diarrhea in China found that rotavirus infection is the most common cause of severe diarrhea in young children. In the present study, surveillance of rotavirus diarrhea was conducted involving 9549 children aged <5 years who were admitted for treatment of diarrhea at 11 sentinel hospitals in China from August 2003 through July 2007. Group A rotavirus was detected in 3749 (47.8%) of the 7846 fecal specimens by using enzyme-linked immunosorbent assay. Rotavirus isolates were characterized by reverse-transcriptase polymerase chain reaction to determine G and P genotypes. All the strains that are common worldwide were detected; G3P[8] was the most common. An unusual G5 strain was detected in 2 specimens. Of all episodes of rotavirus diarrhea, 94% occurred during the first 2 years of life, peaking at 6-23 months of age. Our findings indicate that globally common rotavirus strains continue to be a major cause of severe childhood diarrhea in China. Introduction of routine immunization with effective rotavirus vaccines would substantially reduce this burden. C1 [Fang, Zhao-Yin] Chinese Ctr Dis Control & Prevent, Dept Viral Diarrhea, Natl Inst Viral Dis control & Prevent, Beijing 100052, Peoples R China. [Qian, Yuan] Capital Inst Pediat, Beijing, Peoples R China. [Sun, Li-Wei] Changchun Childrens Hosp, Changchun, Peoples R China. [Tang, Jing-Yu] Lulong Cty Ctr Dis Control & Prevent, Qing Huangdao, Peoples R China. [Jin, Yu] Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China. [Du, Zeng-Qing] Kunming Childrens Hosp, Kunming, Peoples R China. [Xu, Jin] Fudan Univ, Pediat Hosp, Shanghai 200433, Peoples R China. [Wu, Qing-bin] Suzhou Childrens Hosp, Suzhou, Peoples R China. [Tong, Zhi-li] Chizhou City Ctr Dis Control & Prevent, Chizhou, Peoples R China. [Gong, Si-tang] Guangzhou Childrens Hosp, Guangzhou, Guangdong, Peoples R China. [Ma, Jian-min] Xinjiang Reg Ctr Dis Control & Prevent, Urumqi, Peoples R China. [Liao, Xu-chun] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Peoples R China. [Widdowson, Marc-Alain; Jiang, Baoming] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Fang, ZY (reprint author), Chinese Ctr Dis Control & Prevent, Dept Viral Diarrhea, Natl Inst Viral Dis control & Prevent, 100 Ying Xin St, Beijing 100052, Peoples R China. EM fangzhyn@263.net OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU Rotavirus Vaccine Program, Appropriate Technology in Health [GAV.1142-01-07228-LPB]; Department of Vaccines and Biologicals, World Health Organization [V27/181/123] FX Financial support: Rotavirus Vaccine Program, Appropriate Technology in Health (GAV.1142-01-07228-LPB); and Department of Vaccines and Biologicals, World Health Organization (V27/181/123). NR 18 TC 31 Z9 45 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S167 EP S173 DI 10.1086/605039 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100020 PM 19817597 ER PT J AU Flem, ET Musabaev, E Juraev, R Kerin, T Gentsch, J Glass, RI Bresee, JS AF Flem, Elmira T. Musabaev, Erkin Juraev, Rivojiddin Kerin, Tara Gentsch, Jon Glass, Roger I. Bresee, Joseph S. TI Rotavirus Gastroenteritis in Uzbekistan: Implications for Vaccine Policy in Central Asia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID POLYMERASE CHAIN-REACTION; STRAINS; DISEASE; IMPLEMENTATION; EFFICACY; SAFETY; PCR AB Background. To determine the value of rotavirus vaccines in Central Asia, we conducted surveillance of rotavirus in Uzbekistan, the country with the largest birth cohort in the region. Uzbekistan is eligible for international funds to introduce new vaccines. Methods. We screened stool samples for rotavirus that were collected from children aged <5 years with gastroenteritis in 2 hospitals during 2005-2006. Using surveillance information and other data, we estimated national numbers of rotavirus-associated events per year. Results. Of 3537 enrolled children, 1046 (30%) had rotavirus detected in stool specimens. Children aged <2 years accounted for 841 (80%) of all rotavirus infections. The G1P[8] genotype was identified in 27 (52%) of 52 typed samples collected in 2005. Rotavirus is estimated to cause 1174-1857 deaths and 6394-6558 hospitalizations among children aged <5 years annually. The cumulative risk of hospitalization for rotavirus by age 5 years is 1 in 94-96 children, and the risk of rotavirus-related death is 1 in 330-524 children. Conclusions. One-third of all hospitalizations for gastroenteritis and almost 5% of all deaths among children aged <5 years in Uzbekistan may be attributable to rotavirus. Introduction of rotavirus vaccines into the national immunization program at the current subsidized prices could be cost-effective. C1 [Flem, Elmira T.] Norwegian Inst Publ Hlth, Div Infect Dis Control, N-0403 Oslo, Norway. [Musabaev, Erkin; Juraev, Rivojiddin] Res Inst Virol, Tashkent, Uzbekistan. [Kerin, Tara; Gentsch, Jon; Bresee, Joseph S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int, Bethesda, MD 20892 USA. RP Flem, ET (reprint author), Norwegian Inst Publ Hlth, Div Infect Dis Control, POB 4404, N-0403 Oslo, Norway. EM elmira.flem@fhi.no FU GAVI Alliance; US Centers for Disease Control and Prevention; Norwegian Institute of Public Health FX Financial support: GAVI Alliance, US Centers for Disease Control and Prevention, and Norwegian Institute of Public Health. NR 24 TC 7 Z9 7 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S154 EP S159 DI 10.1086/605032 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100018 PM 19817594 ER PT J AU Gentsch, JR Hull, JJ Teel, EN Kerin, TK Freeman, MM Esona, MD Griffin, DD Bielfelt-Krall, BP Banyai, K Jiang, BM Cortese, MM Glass, RI Parashar, UD AF Gentsch, Jon R. Hull, Jennifer J. Teel, Elizabeth N. Kerin, Tara K. Freeman, Molly M. Esona, Mathew D. Griffin, Dixie D. Bielfelt-Krall, Brittany P. Banyai, Krisztian Jiang, Baoming Cortese, Margaret M. Glass, Roger I. Parashar, Umesh D. CA Natl Rotavirus Strain Surveillance TI G and P Types of Circulating Rotavirus Strains in the United States during 1996-2005: Nine Years of Prevaccine Data SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID POLYMERASE CHAIN-REACTION; G12 HUMAN ROTAVIRUSES; GROUP-A ROTAVIRUSES; MOLECULAR EPIDEMIOLOGY; VACCINATED POPULATION; SEROTYPE VARIATION; SOUTH-INDIA; CHILDREN; GASTROENTERITIS; IDENTIFICATION AB Background. Rotavirus vaccine was recommended for routine use among US infants in 2006. To provide prevaccine data, we conducted strain surveillance for 9 consecutive seasons during 1996-2005. Methods. Using reverse-transcriptase polymerase chain reaction genotyping and nucleotide sequencing, we determined P/G genotypes of >3100 rotavirus strains collected in up to 12 cities each year from different US regions. Results. The most prevalent strain globally, P[8] G1, was the most prevalent each year in the United States (overall, 78.5% of strains; range, 60.0%-93.9%), and 9.2% of the samples were P[4] G2, 3.6% were P[8] G9, 1.7% were P[8] G3, and 0.8% were P[8] G4. Genotype P[6] G9, which emerged in 1995, was detected continuously for several seasons (from 1996-1997 to 2000-2001, 0.2%-5.4%) but was not identified in the subsequent 4 seasons. Single or a few detections of rare genotypes (eg, P[6] G12, P[9] G6, and P[9] G3) were observed during several rotavirus seasons at frequencies of 0.5%-1.7% and, overall, comprised 0.6% of all the samples from the entire surveillance period. Several globally common strains in addition to G1, especially G2 and G9, circulated at high prevalence (33%-62%) in some cities during certain years. Conclusions. Almost 85% of strains during 1996-2005 had either a G or P antigen that is present in both RotaTeq (Merck) and Rotarix (GlaxoSmithKline). Monitoring of strains after introduction of rotavirus vaccines is important. C1 [Gentsch, Jon R.; Griffin, Dixie D.; Bielfelt-Krall, Brittany P.; Jiang, Baoming] Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. [Cortese, Margaret M.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Freeman, Molly M.; Esona, Mathew D.] Med Staffing Network, Atlanta, GA USA. [Hull, Jennifer J.; Teel, Elizabeth N.; Kerin, Tara K.] Atlanta Res & Educ Fdn, Decatur, GA USA. [Banyai, Krisztian] Assoc Publ Hlth Labs, Washington, DC USA. [Glass, Roger I.] Fogarty Int Ctr, Bethesda, MD USA. RP Gentsch, JR (reprint author), Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, MS G-04,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jrg4@cdc.gov OI Banyai, Krisztian/0000-0002-6270-1772 FU National Vaccine Program Office of the Department of Health and Human Services, Centers for Disease Control and Prevention FX Financial support: National Vaccine Program Office of the Department of Health and Human Services, Centers for Disease Control and Prevention. NR 52 TC 37 Z9 38 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S99 EP S105 DI 10.1086/605038 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100013 PM 19817622 ER PT J AU Kamiya, H Nakano, T Inoue, M Kamiya, H Abd, TT Patel, M Orenstein, WA Parashar, UD AF Kamiya, Hajime Nakano, Takashi Inoue, Masakazu Kamiya, Hitoshi Abd, Thura T. Patel, Manish Orenstein, Walter A. Parashar, Umesh D. TI A Retrospective Evaluation of Hospitalizations for Acute Gastroenteritis at 2 Sentinel Hospitals in Central Japan to Estimate the Health Burden of Rotavirus SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CUMULATIVE RISK; CHILDREN; DIARRHEA; EFFICACY; VACCINE; DISEASE; SAFETY AB Background. Two rotavirus vaccines have recently been licensed for use in >80 countries worldwide but not in Japan. To assess the value of introducing rotavirus vaccination in Japan, data on the burden of rotavirus disease are needed. Methods. To describe the epidemiology of severe rotavirus disease among Japanese children aged <5 years, we examined retrospective demographic, clinical, and laboratory data from the period 2003-2007 for children hospitalized with acute gastroenteritis (AGE) at 2 sentinel hospitals in Japan. Results. At each of the 2 hospitals, 17%-21% of all pediatric hospitalizations were for AGE. Three-fourths of all AGE-related admissions occurred during the winter (December-May). Rotavirus testing was performed for approximately three-fourths of patients admitted with AGE in the winter, of which 55% at one hospital and 59% at the other tested positive. By extrapolating the test results to those patients with AGE admitted in the winter who were not tested, we estimated that 39%-44% of year-round and 52%-57% of winter hospitalizations were attributable to rotavirus. The annual incidence of hospitalization for rotavirus AGE in the 2 cities served by the hospitals was estimated to be 3.8 and 4.9 per 1000 person-years. Conclusions. The burden of severe rotavirus disease among Japanese children is substantial and warrants consideration of vaccination as a prevention strategy. C1 [Patel, Manish; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30322 USA. [Kamiya, Hajime; Abd, Thura T.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Orenstein, Walter A.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Nakano, Takashi; Kamiya, Hitoshi] Mie Natl Hosp, Div Pediat, Tsu, Mie, Japan. [Inoue, Masakazu] Yamada Red Cross Hosp, Div Pediat, Ise, Mie, Japan. RP Parashar, UD (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,Mailstop A-47, Atlanta, GA 30322 USA. EM uap2@cdc.gov FU Health and Labor Sciences Research Grants; Research on Regulatory Science of Pharmaceuticals and Medical Devices; Japanese Ministry of Health and Welfare FX Financial support: Health and Labor Sciences Research Grants, Research on Regulatory Science of Pharmaceuticals and Medical Devices, Japanese Ministry of Health and Welfare. NR 15 TC 18 Z9 20 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S140 EP S146 DI 10.1086/605028 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100016 PM 19817592 ER PT J AU Kang, G Arora, R Chitambar, SD Deshpande, J Gupte, MD Kulkarni, M Naik, TN Mukherji, D Venkatasubramaniam, S Gentsch, JR Glass, RI Parashar, UD AF Kang, Gagandeep Arora, Rashmi Chitambar, Shobha D. Deshpande, Jagdish Gupte, M. D. Kulkarni, Madhuri Naik, Trilok N. Mukherji, Dipali Venkatasubramaniam, S. Gentsch, Jon R. Glass, Roger I. Parashar, Umesh D. CA Indian Rotavirus Strain Surveillan TI Multicenter, Hospital-Based Surveillance of Rotavirus Disease and Strains among Indian Children Aged < 5 Years SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ACUTE DIARRHEA; SOUTH-INDIA; MOLECULAR EPIDEMIOLOGY; G12 GENOTYPE; BACTERIAL; EMERGENCE; GASTROENTERITIS; SPECIFICITY; INFECTIONS; VACCINES AB Background. Current, nationally representative data on rotavirus disease burden and rotavirus strains in India are needed to understand the potential health benefits of rotavirus vaccination. Methods. The Indian Rotavirus Strain Surveillance Network was established with 4 laboratories and 10 hospitals in 7 different regions of India. At each hospital, children aged <5 years who presented with acute gastroenteritis and required hospitalization with rehydration for at least 6 h were enrolled. A fecal specimen was obtained and was tested for rotavirus with use of a commercial enzyme immunoassay, and strains were characterized using reverse-transcription polymerase chain reaction. Results. From December 2005 through November 2007, rotavirus was found in similar to 39% of 4243 enrolled patients. Rotavirus was markedly seasonal in northern temperate locations but was less seasonal in southern locations with a tropical climate. Rotavirus detection rates were greatest among children aged 6-23 months, and 13.3% of rotavirus infections involved children aged <6 months. The most common types of strains were G2P[4] (25.7% of strains), G1P[8] (22.1%), and G9P[8] (8.5%); G12 strains were seen in combination with types P[4], P[6], and P[8] and together comprised 6.5% of strains. Conclusions. These data highlight the need for development and implementation of effective prophylactic measures, such as vaccines, to prevent the large burden of rotavirus disease among Indian children. C1 [Arora, Rashmi] Indian Council Med Res, Epidemiol & Communicable Dis Div, New Delhi 110029, India. [Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India. [Chitambar, Shobha D.] Natl Inst Virol, Pune, Maharashtra, India. [Kulkarni, Madhuri] Lokmanya Tilak Municipal Gen Hosp, Bombay, Maharashtra, India. [Gupte, M. D.; Venkatasubramaniam, S.] Natl Inst Epidemiol, Madras, Tamil Nadu, India. [Naik, Trilok N.] Natl Inst Cholera & Enter Dis, Kolkata, India. [Gentsch, Jon R.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Arora, R (reprint author), Indian Council Med Res, Epidemiol & Communicable Dis Div, New Delhi 110029, India. EM arorar@icmr.org.in OI Deshpande, Jagadish/0000-0001-5194-0375 FU Indian Council for Medical Research, New Delhi; US Centers for Disease Control and Prevention FX Financial support: Indian Council for Medical Research, New Delhi; and US Centers for Disease Control and Prevention. NR 26 TC 70 Z9 70 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S147 EP S153 DI 10.1086/605031 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100017 PM 19817593 ER PT J AU Mirzayeva, R Cortese, MM Mosina, L Biellik, R Lobanov, A Chernyshova, L Lashkarashvili, M Turkov, S Iturriza-Gomara, M Gray, J Parashar, UD Steele, D Emiroglu, N AF Mirzayeva, Radmila Cortese, Margaret M. Mosina, Liudmila Biellik, Robin Lobanov, Andrei Chernyshova, Lyudmila Lashkarashvili, Marina Turkov, Soibnazar Iturriza-Gomara, Miren Gray, Jim Parashar, Umesh D. Steele, Duncan Emiroglu, Nedret CA Rotavirus Surveillance Network TI Rotavirus Burden among Children in the Newly Independent States of the Former Union of Soviet Socialist Republics: Literature Review and First-Year Results from the Rotavirus Surveillance Network SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ENZYME-IMMUNOASSAY; MOLECULAR EPIDEMIOLOGY; ACUTE GASTROENTERITIS; HEMAGGLUTINATION TEST; UNITED-KINGDOM; DIAGNOSIS; VACCINE; INFECTIONS; EUROPE; EFFICACY AB Background. Data on rotavirus burden among children in the 15 newly independent states of the former Union of Soviet Socialist Republics, particularly contemporary data from poorer countries, are not widely available. These data are desired by policy makers to assess the value of rotavirus vaccination, especially since the GAVI Alliance approved financial support for the region's eligible countries. The Rotavirus Surveillance Network was established to provide these data. Methods. We reviewed the region's literature on rotavirus burden. We established an active surveillance network for rotavirus and analyzed data from 2007 from 4 sentinel hospitals in 3 countries (Georgia, Tajikistan, and Ukraine) that were collected using standardized enrollment and stool sample testing methods. Results. Specimens for rotavirus testing were collected before 1997 in most studies, and the majority of studies were from 1 country, the Russian Federation. Overall, the studies indicated that similar to 33% of hospitalizations for gastroenteritis among children were attributable to rotavirus. The Rotavirus Surveillance Network documented that 1425 (42%) of 3374 hospitalizations for acute gastroenteritis among children aged <5 years were attributable to rotavirus (site median, 40%). Seasonal peaks (autumn through spring) were observed. Genotype data on 323 samples showed that G1P[8] was the most common type (32%), followed by G9P[8] (20%), G2P[4] (18%), and G4P[8] (18%). Infections due to G10 and G12 and mixed infections were also detected. Conclusions. The burden of rotavirus disease in the newly independent states is substantial. Vaccines should be considered for disease prevention. C1 [Mirzayeva, Radmila; Biellik, Robin] PATH, Ferney Voltaire, France. [Cortese, Margaret M.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. [Mosina, Liudmila; Lobanov, Andrei; Emiroglu, Nedret] WHO, Reg Off Europe, DK-2100 Copenhagen, Denmark. [Chernyshova, Lyudmila] Natl Med Acad Post Grad Educ, Kiev, Ukraine. [Lashkarashvili, Marina] Natl Ctr Dis Control & Med Stat, Tbilisi, Rep of Georgia. [Iturriza-Gomara, Miren; Gray, Jim] Hlth Protect Agcy, Ctr Infect, Virus Reference Dept, London, England. [Steele, Duncan] World Hlth Org, Initiat Vaccine Res, Geneva, Switzerland. RP Mirzayeva, R (reprint author), Rue Sonnex 19,1218 Grand Saconnex, Geneva, Switzerland. EM mirzayeva@gmail.com RI Iturriza Gomara, Miren/B-4351-2013 OI Iturriza Gomara, Miren/0000-0001-5816-6423 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 53 TC 11 Z9 11 U1 1 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S203 EP S214 DI 10.1086/605041 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100024 PM 19817601 ER PT J AU Ortega, O El-Sayed, N Sanders, JW Abd-Rabou, Z Antil, L Bresee, J Mansour, A Adib, I Nahkla, I Riddle, MS AF Ortega, Omayra El-Sayed, Nasr Sanders, John W. Abd-Rabou, Zakaria Antil, Lynn Bresee, Joseph Mansour, Adel Adib, Ibrahim Nahkla, Isabelle Riddle, Mark S. TI Cost-Benefit Analysis of a Rotavirus Immunization Program in the Arab Republic of Egypt SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID YOUNG-CHILDREN; DIARRHEA; DISEASE; ENTEROPATHOGENS; EPIDEMIOLOGY; VACCINATION; INFANTS; DEATHS; LIVE AB Background. The availability of rotavirus vaccines makes the implementation of a national immunization program an important decision requiring economic considerations. Methods. A cost-benefit analysis of a national rotavirus immunization program in Egypt, from the perspective of the Ministry of Health and Population, and a cost-effectiveness analysis, from a societal perspective, were conducted. Results. For a birth cohort of 1.9 million children, a vaccination program was estimated to prevent 1,140,496 episodes of diarrhea, 438,395 outpatient visits, and 47,508 hospitalizations and to save 2873 lives, resulting in direct Ministry of Health and Population medical savings of $2,481,792 (14,369,578 Egyptian pounds [LE]). On the basis of a $9.18 (53 LE) single-dose cost, rotavirus vaccine introduction would cost the Ministry of Health and Population $34,203,445.87 (198,037,951.56 LE) in health expenditures. This equates to an incremental cost of $30.22 (174.95 LE) per infection prevented. Vaccination would prevent the loss of 94,993 disability-adjusted life-years, resulting in an incremental cost-effectiveness ratio of $363 per disability-adjusted life-year. Conclusions. The introduction of rotavirus vaccine to the national immunization program was not found to be cost saving based strictly from the Ministry of Health and Population perspective; however, the potential benefits of long-term health and economic gains from reduced mortality and morbidity, decreased direct costs of care for families, and indirect societal costs should be considered in such decisions. C1 [Ortega, Omayra] Arizona State Univ, Div Math & Nat Sci, Phoenix, AZ 85069 USA. [Antil, Lynn; Bresee, Joseph] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sanders, John W.; Mansour, Adel; Adib, Ibrahim; Nahkla, Isabelle; Riddle, Mark S.] Naval Med Res Unit 3, Enter Dis Res Program, Cairo, Egypt. RP Ortega, O (reprint author), Arizona State Univ, Div Math & Nat Sci, POB 37100, Phoenix, AZ 85069 USA. EM omayra.ortega@asu.edu RI Riddle, Mark/A-8029-2011 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 25 TC 14 Z9 14 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S92 EP S98 DI 10.1086/605057 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100012 PM 19817621 ER PT J AU Parashar, UD Burton, A Lanata, C Boschi-Pinto, C Shibuya, K Steele, D Birmingham, M Glass, RI AF Parashar, Umesh D. Burton, Anthony Lanata, Claudio Boschi-Pinto, Cynthia Shibuya, Kenji Steele, Duncan Birmingham, Maureen Glass, Roger I. TI Global Mortality Associated with Rotavirus Disease among Children in 2004 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID DIARRHEA; EFFICACY; VACCINE; DEATHS; SAFETY AB Background. As new rotavirus vaccines are being introduced in immunization programs, global and national estimates of disease burden, especially rotavirus-associated mortality, are needed to assess the potential health benefits of vaccination and to monitor vaccine impact. Methods. We identified 76 studies that were initiated after 1990, lasted at least 1 full year, and examined rotavirus among 1100 children hospitalized with diarrhea. The studies were assigned to 5 groups (A-E) with use of World Health Organization classification of countries by child mortality and geography. For each group, the mean rotavirus detection rate was multiplied by diarrhea-related mortality figures from 2004 for countries in that group to yield estimates of rotavirus-associated mortality. Results. Overall, rotavirus accounted for 527,000 deaths (95% confidence interval, 475,000-580,000 deaths) annually or 29% of all deaths due to diarrhea among children ! 5 years of age. Twenty-three percent of deaths due to rotavirus disease occurred in India, and 6 countries (India, Nigeria, Congo, Ethiopia, China, and Pakistan) accounted for more than one-half of deaths due to rotavirus disease. Conclusions. The high mortality associated with rotavirus disease underscores the need for targeted interventions, such as vaccines. To realize the full life-saving potential of vaccines, it will be vital to ensure that they reach children in countries with high mortality. These baseline figures will allow future assessment of vaccine impact on rotavirus-associated mortality. C1 [Parashar, Umesh D.; Glass, Roger I.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Burton, Anthony; Boschi-Pinto, Cynthia; Shibuya, Kenji; Steele, Duncan; Birmingham, Maureen] World Hlth Org, Geneva, Switzerland. [Lanata, Claudio] Inst Nutr, Lima, Peru. RP Parashar, UD (reprint author), Viral Gastroenteritis Sect, MS G-04 CDC,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM uap2@cdc.gov FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 15 TC 299 Z9 316 U1 0 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S9 EP S15 DI 10.1086/605025 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100002 PM 19817620 ER PT J AU Patel, M Shane, AL Parashar, UD Jiang, BM Gentsch, JR Glass, RI AF Patel, Manish Shane, Andi L. Parashar, Umesh D. Jiang, Baoming Gentsch, Jon R. Glass, Roger I. TI Oral Rotavirus Vaccines: How Well Will They Work Where They Are Needed Most? SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TETRAVALENT RHESUS-HUMAN; POLIOVIRUS VACCINE; CHILDHOOD DIARRHEA; GAMBIAN INFANTS; YOUNG-CHILDREN; WC3 VACCINE; HUMAN-MILK; EFFICACY; IMMUNOGENICITY; SAFETY AB Rotavirus vaccines hold promise to decrease the burden of severe diarrhea in the poorest countries, where 85% of deaths due to rotavirus occur. However, the potency of live oral vaccines is lower in these challenging settings than in middle- and upper-income countries. Many hypotheses have been suggested to explain these differences that could provide clues to improve the ultimate success of these novel vaccines. Although introduction today of even moderately effective vaccines will decrease the morbidity and mortality associated with rotavirus in low-income settings, research is urgently needed to understand why these differences in efficacy occur and what could be done to improve vaccine performance to maximize the life-saving benefits of vaccination. C1 [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Patel, Manish; Parashar, Umesh D.; Jiang, Baoming; Gentsch, Jon R.; Glass, Roger I.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Shane, Andi L.] Emory Univ, Dept Pediat, Div Infect Dis, Atlanta, GA 30322 USA. RP Glass, RI (reprint author), NIH, Fogarty Int Ctr, 31 Ctr Dr,MSC 2220, Bethesda, MD 20892 USA. EM glassr@mail.nih.gov FU National Institutes of Health National Center for Research Resources [1KL2RR025009] FX Financial support: National Institutes of Health National Center for Research Resources (1KL2RR025009 to A.S.). NR 73 TC 106 Z9 106 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S39 EP S48 DI 10.1086/605035 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100005 PM 19817613 ER PT J AU Patel, MM Parashar, UD AF Patel, Manish M. Parashar, Umesh D. TI Assessing the Effectiveness and Public Health Impact of Rotavirus Vaccines after Introduction in Immunization Programs SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID 1ST 2 YEARS; CONCOMITANT USE; UNITED-STATES; DOUBLE-BLIND; EFFICACY; INFANTS; SAFETY; LIVE; GASTROENTERITIS; RIX4414 AB Two new vaccines against severe rotavirus gastroenteritis that have high efficacy in middle-and high-income countries have recently been licensed in many countries worldwide. Clinical trials in low-income countries in Africa and Asia are ongoing. Experience gained through studies of natural rotavirus infection and the clinical trials for the current and previous rotavirus vaccines indicate that, as countries begin to introduce these newly approved vaccines into routine childhood immunization programs, monitoring their performance in real world settings should be a high priority. Key epidemiological considerations in the postlicensure period include (1) how the vaccine will perform against severe rotavirus disease under routine public health use; (2) how routine vaccination will impact the epidemiology of disease with regard to the burden of severe disease and death, age distribution of cases, seasonality, and serotype distribution; (3) whether vaccination will have a sufficient impact on transmission to reduce disease burden in unvaccinated age groups; and (4) whether vaccine will confer protection through the first 3 years of life, when most severe disease and mortality associated with rotavirus occur. Monitoring of impact with focus on these public health considerations will allow parents, health care providers, and decision makers to appreciate the health benefits of vaccination in reducing the burden of severe rotavirus disease. It will also allow assessment of the effectiveness of rotavirus vaccines in programmatic use and the need for modifying vaccination schedules or vaccine formulations to enhance the performance of immunization. In this article, we review data for the protective efficacy of the 2 new rotavirus vaccines, with emphasis on issues particularly important for consideration as these vaccines are introduced in routine infant immunization programs. C1 [Patel, Manish M.] Ctr Dis Control & Prevent, Viral Gastroenteritis Sect, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Patel, MM (reprint author), Ctr Dis Control & Prevent, Viral Gastroenteritis Sect, Natl Ctr Immunizat & Resp Dis, MS-A47,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM Aul3@cdc.gov FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 41 TC 30 Z9 32 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S291 EP S299 DI 10.1086/605059 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100034 PM 19817612 ER PT J AU Podkolzin, AT Fenske, EB Abramycheva, NY Shipulin, GA Sagalova, OI Mazepa, VN Ivanova, GN Semena, AV Tagirova, ZG Alekseeva, MN Molochny, VP Parashar, UD Vinje, J Maleev, VV Glass, RI Pokrovsky, VI AF Podkolzin, A. T. Fenske, E. B. Abramycheva, N. Yu Shipulin, G. A. Sagalova, O. I. Mazepa, V. N. Ivanova, G. N. Semena, A. V. Tagirova, Z. G. Alekseeva, M. N. Molochny, V. P. Parashar, U. D. Vinje, J. Maleev, V. V. Glass, R. I. Pokrovsky, V. I. TI Hospital-Based Surveillance of Rotavirus and Other Viral Agents of Diarrhea in Children and Adults in Russia, 2005-2007 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID POLYMERASE CHAIN-REACTION; GROUP-A ROTAVIRUS; UNITED-STATES; INFECTION; DISEASE; DEATHS; SEASON; INDIA; DELHI AB During a 2-year period in 2005-2007, we conducted surveillance of group A rotaviruses and other enteric agents among patients hospitalized with acute gastroenteritis in 8 different cities of the Russian Federation. Fecal specimens were gathered from 3208 children (including 2848 children aged <5 years) and 1354 adults who were admitted to hospitals in Moscow, St. Petersburg, Chelyabinsk, Nizhnii Novgorod, Tyumen, Khabarovsk, Makhachkala, and Yakutsk. Polymerase chain reaction was performed to detect rotaviruses of groups A and C, noroviruses of genogroups I and II, astrovirus, sapovirus, and enteric adenoviruses (group F). Group A rotavirus was the most common viral pathogen detected among children aged <5 years (43.6%), followed by norovirus (12.5%), whereas norovirus was the pathogen most commonly detected in adults (11.9%). P and G genotypes were determined for 515 rotavirus specimens, and the most prevalent genotypes were G1P[8] (44.9%), G4P[8] (40.0%), G2P[4] (8.5%), and G3P[8] (6.6%). This study is the first multicenter study of rotaviruses in the Russian Federation and documents the important burden of disease caused by this pathogen, which soon may be preventable by vaccination. C1 [Podkolzin, A. T.; Fenske, E. B.; Abramycheva, N. Yu; Shipulin, G. A.; Maleev, V. V.; Pokrovsky, V. I.] Cent Res Inst Epidemiol, Moscow 111123, Russia. [Sagalova, O. I.] Chelyabinsk State Med Acad, Chelyabinsk, Russia. [Mazepa, V. N.] Inst Epidemiol & Microbiol, Nizhnii Novgorod, Russia. [Ivanova, G. N.] Reg Infect Clin Hosp, Tyumen, Russia. [Semena, A. V.] Russian Army Med Acad, St Petersburg, Russia. [Tagirova, Z. G.] Daghestan State Med Acad, Makhachkala, Russia. [Alekseeva, M. N.] Yakut State Univ, Yakutsk, Russia. [Molochny, V. P.] Far Eastern Med Univ, Khabarovsk, Russia. [Parashar, U. D.; Vinje, J.; Glass, R. I.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glass, R. I.] Fogarty Int Ctr, Bethesda, MD USA. RP Podkolzin, AT (reprint author), Cent Res Inst Epidemiol, Novogireevskaya 3A, Moscow 111123, Russia. EM apodkolzin@pcr.ru OI Podkolzin, Alexandr/0000-0002-0044-3341; Vinje, Jan/0000-0002-1530-3675; Shipulin, German/0000-0002-3668-6601 FU International Science and Technology Center [2935] FX Financial support: International Science and Technology Center 2935/Biotechnology Engagement Program 58 grant. NR 18 TC 31 Z9 35 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S228 EP S233 DI 10.1086/605054 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100025 PM 19817602 ER PT J AU Rheingans, RD Antil, L Dreibelbis, R Podewils, LJ Bresee, JS Parashar, UD AF Rheingans, Richard D. Antil, Lynn Dreibelbis, Robert Podewils, Laura Jean Bresee, Joseph S. Parashar, Umesh D. TI Economic Costs of Rotavirus Gastroenteritis and Cost-Effectiveness of Vaccination in Developing Countries SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SENTINEL HOSPITAL SURVEILLANCE; UPPER RIVER DIVISION; 8 LATIN-AMERICAN; DISEASE BURDEN; EPIDEMIOLOGIC FEATURES; CHILDHOOD MORTALITY; DIARRHEAL DISEASE; HONG-KONG; CARIBBEAN COUNTRIES; INFANT-MORTALITY AB Background. Rotavirus is the leading cause of severe gastroenteritis in children worldwide. We evaluated the economic burden of rotavirus and the cost-effectiveness of vaccination from the health care perspective. Methods. Estimates were based on existing epidemiological data, cost estimates, vaccine coverage, and efficacy data, as well as hypothetical vaccine prices. Outcome measures included health care and societal costs of rotavirus and benefits and incremental cost-effectiveness ratio of vaccination. Sensitivity analyses evaluated the impact of estimate uncertainty. Results. Treatment costs increased with income level, and health burden decreased; however, burden varied across regions. On the basis of current vaccination coverage and timing, rotavirus vaccination would annually prevent 228,000 deaths, 13.7 million hospital visits, and 8.7 million disability-adjusted life-years, saving $188 million in treatment costs and $243 million in societal costs. At $5 per dose, the incremental cost-effectiveness ratio in low-, lower-middle-, and upper-middle-income countries was $88, $291, and $329 per disability-adjusted life-year averted, respectively, and $3,015, $9,951 and $11,296 per life saved, respectively. Vaccination would prevent similar to 45% of deaths and similar to 58% of associated medical visits and costs. Conclusions. Vaccination is a cost-effective strategy to reduce the health and economic burden of rotavirus. The cost-effectiveness of vaccination depends mostly on vaccine price and reaching children at highest risk of mortality. C1 [Rheingans, Richard D.; Antil, Lynn; Dreibelbis, Robert] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Podewils, Laura Jean; Bresee, Joseph S.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Viral Enter Epidemiol Team, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Rheingans, RD (reprint author), Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, 1518 Clifton Rd, Atlanta, GA 30322 USA. EM rrheing@sph.emory.edu OI Dreibelbis, Robert/0000-0002-9716-0419 FU Global Alliance for Vaccines and Immunization (GAVI); The Vaccine Fund [GAV1142-01-07240-SPS] FX Financial support: Global Alliance for Vaccines and Immunization (GAVI) and The Vaccine Fund (GAV1142-01-07240-SPS). The model used in this analysis was based on a model developed with the support of GSK Biologicals. NR 78 TC 55 Z9 57 U1 1 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S16 EP S27 DI 10.1086/605026 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100003 PM 19817595 ER PT J AU Steele, AD Patel, M Parashar, UD Victor, JC Aguado, T Neuzil, KM AF Steele, A. Duncan Patel, Manish Parashar, Umesh D. Victor, John C. Aguado, Teresa Neuzil, Kathleen M. TI Rotavirus Vaccines for Infants in Developing Countries in Africa and Asia: Considerations from a World Health Organization-Sponsored Consultation SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID EFFICACY; SAFETY AB The World Health Organization (WHO) and its international partners have prioritized the development of rotavirus vaccines for the past 3 decades. In November 2005, the WHO's Strategic Advisory Group of Experts first reviewed the clinical efficacy data from 2 new live attenuated oral rotavirus vaccines, which demonstrated excellent protective efficacy against severe rotavirus disease in regions where they were evaluated. Despite these successes, the WHO has urged the clinical evaluation of these vaccines in populations of Africa and Asia, where most of the deaths due to rotavirus occur, and has emphasized the need for ongoing postlicensure safety monitoring in countries introducing vaccines. Clinical studies in Africa and Asia will soon provide data on the efficacy of both new vaccines in these populations. A WHO international consultative meeting convened to evaluate how to use these imminent data for the future use of rotavirus vaccines in developing countries. In brief, it was agreed that (1) even vaccines with lesser efficacy in developing countries, compared with industrialized countries, would still lead to substantial public health benefits and would be cost-effective in saving lives in Africa and Asia; (2) criteria, such as the WHO mortality strata and local epidemiology of rotavirus infection, would be appropriate measures for extrapolating the clinical data to other regions and countries; and (3) research toward understanding the programmatic limitations of rotavirus vaccine use may help develop strategies to improve vaccine uptake and overall impact. C1 [Steele, A. Duncan; Victor, John C.; Neuzil, Kathleen M.] PATH, Seattle, WA 98107 USA. [Steele, A. Duncan; Aguado, Teresa] World Hlth Org, Initiat Vaccine Res, Geneva, Switzerland. [Patel, Manish; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Steele, AD (reprint author), PATH, 1455 Leary Way NW, Seattle, WA 98107 USA. EM dsteele@path.org OI Victor, John/0000-0002-7970-6588 FU Initiative for Vaccine Research, World Health Organization FX Financial support: Initiative for Vaccine Research, World Health Organization. NR 22 TC 14 Z9 14 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S63 EP S69 DI 10.1086/605042 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100008 PM 19817616 ER PT J AU Tate, JE Rheingans, RD O'Reilly, CE Obonyo, B Burton, DC Tornheim, JA Adazu, K Jaron, P Ochieng, B Kerin, T Calhoun, L Hamel, M Laserson, K Breiman, RF Feikin, DR Mintz, ED Widdowson, MA AF Tate, Jacqueline E. Rheingans, Richard D. O'Reilly, Ciara E. Obonyo, Benson Burton, Deron C. Tornheim, Jeffrey A. Adazu, Kubaje Jaron, Peter Ochieng, Benjamin Kerin, Tara Calhoun, Lisa Hamel, Mary Laserson, Kayla Breiman, Robert F. Feikin, Daniel R. Mintz, Eric D. Widdowson, Marc-Alain TI Rotavirus Disease Burden and Impact and Cost-Effectiveness of a Rotavirus Vaccination Program in Kenya SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RURAL WESTERN KENYA; DEMOGRAPHIC SURVEILLANCE; DIARRHEA; CHILDREN; GASTROENTERITIS; MORTALITY AB Background. The projected impact and cost-effectiveness of rotavirus vaccination are important for supporting rotavirus vaccine introduction in Africa, where limited health intervention funds are available. Methods. Hospital records, health utilization surveys, verbal autopsy data, and surveillance data on diarrheal disease were used to determine rotavirus-specific rates of hospitalization, clinic visits, and deaths due to diarrhea among children <5 years of age in Nyanza Province, Kenya. Rates were extrapolated nationally with use of province-specific data on diarrheal illness. Direct medical costs were estimated using record review and World Health Organization estimates. Household costs were collected through parental interviews. The impact of vaccination on health burden and on the cost-effectiveness per disability-adjusted life-year and lives saved were calculated. Results. Annually in Kenya, rotavirus infection causes 19% of hospitalizations and 16% of clinic visits for diarrhea among children <5 years of age and causes 4471 deaths, 8781 hospitalizations, and 1,443,883 clinic visits. Nationally, rotavirus disease costs the health care system $10.8 million annually. Routine vaccination with a 2-dose rotavirus vaccination series would avert 2467 deaths (55%), 5724 hospitalizations (65%), and 852,589 clinic visits (59%) and would save 58 disability-adjusted life-years per 1000 children annually. At $3 per series, a program would cost $2.1 million in medical costs annually; the break-even price is $2.07 per series. Conclusions. A rotavirus vaccination program would reduce the substantial burden of rotavirus disease and the economic burden in Kenya. C1 [Tate, Jacqueline E.; O'Reilly, Ciara E.; Burton, Deron C.; Kerin, Tara; Mintz, Eric D.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rheingans, Richard D.] Emory Univ, Atlanta, GA 30322 USA. [Calhoun, Lisa] Univ Michigan, Ann Arbor, MI 48109 USA. [Obonyo, Benson; Burton, Deron C.; Tornheim, Jeffrey A.; Adazu, Kubaje; Jaron, Peter; Ochieng, Benjamin; Hamel, Mary; Laserson, Kayla; Feikin, Daniel R.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Tornheim, Jeffrey A.; Adazu, Kubaje; Jaron, Peter; Ochieng, Benjamin; Hamel, Mary; Laserson, Kayla; Feikin, Daniel R.] Ctr Dis Control & Prevent, Kisumu, Kenya. [Breiman, Robert F.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Breiman, Robert F.] Ctr Dis Control & Prevent, Nairobi, Kenya. RP Tate, JE (reprint author), 1600 Clifton Rd NE,MS-A47, Atlanta, GA 30333 USA. EM jqt8@cdc.gov OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 24 TC 46 Z9 46 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S76 EP S84 DI 10.1086/605058 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100010 PM 19817618 ER PT J AU Widdowson, MA Steele, D Vojdani, J Wecker, J Parashar, U AF Widdowson, Marc-Alain Steele, Duncan Vojdani, Jazmin Wecker, John Parashar, Umesh TI Global Rotavirus Surveillance: Determining the Need and Measuring the Impact of Rotavirus Vaccines SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID YOUNG-CHILDREN; WC3 VACCINE; INFANTS; GASTROENTERITIS; EFFICACY; DIARRHEA; INTUSSUSCEPTION; IMMUNIZATION; PROTECTION; INFECTION AB Rotavirus remains the most common cause of severe childhood diarrhea worldwide and of diarrheal mortality in poor countries. In 2003, the GAVI Alliance launched the Rotavirus Vaccine Program and the Accelerated Development and Introduction Plan to close the gap of access to rotavirus vaccines in industrialized and developing countries by generating data on rotavirus disease burden, projected impact, and cost-effectiveness of vaccination and by conducting clinical trials of existing vaccines in impoverished settings. By the end of 2008, rotavirus vaccines were licensed in 1100 countries, although only 17 countries have introduced routine rotavirus vaccination. Increased uptake of the vaccine by countries with the highest childhood mortality will depend in part on a solid evidence base of estimated burden and cost of rotavirus illness. Since 2001, regional surveillance networks worldwide have generated burden and strain data from 196 sites in 59 countries. Among children aged ! 5 years who are hospitalized for severe diarrhea in different regions of the world, a regional median of 39% (range by country, 20%-73%) test positive for rotavirus. Rotavirus vaccines are a cost-effective intervention and may be cost saving with a GAVI Alliance subsidy from the health care perspective. Punctual vaccination and high coverage of populations at highest risk of mortality will maximize the impact of vaccination. Surveillance platforms will allow measurement of the rapid impact of rotavirus vaccine introduction on the heavy burden of rotavirus on child health worldwide. C1 [Widdowson, Marc-Alain; Vojdani, Jazmin; Parashar, Umesh] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. [Steele, Duncan; Wecker, John] PATH, Seattle, WA USA. RP Widdowson, MA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, MS A32,Clifton Rd NE, Atlanta, GA 30329 USA. EM zux5@cdc.gov OI Duque, Jazmin/0000-0003-3484-276X; Widdowson, Marc-Alain/0000-0002-0682-6933 FU GAVI Alliance FX Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. NR 60 TC 46 Z9 46 U1 0 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2009 VL 200 SU 1 BP S1 EP S8 DI 10.1086/605061 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 504YT UT WOS:000270655100001 PM 19817589 ER PT J AU Howell, PI Benedict, MQ AF Howell, P. I. Benedict, M. Q. TI Mating Competitiveness of Anopheles arabiensis Males as a Function of Transgenic State and Genetic Similarity to Females SO JOURNAL OF INSECT BEHAVIOR LA English DT Article DE Transgenic; mating competitiveness; An. arabiensis; assortative mating; mating ability; mating compatibility ID COMPLEX CHROMOSOMAL ABERRATION; STEPHENSI MOSQUITOS; VECTOR CONTROL; CHEMOSTERILIZED MALES; DIPTERA-CULICIDAE; SEXING STRAIN; FIELD TRIALS; POPULATION; FITNESS; TEPHRITIDAE AB We conducted mating competitions between wild-type and heterozygous transgenic Anopheles arabiensis males that were produced by repeated backcrosses of a transposable element expressing the beta 2-tubulin eGFP marker into two genetic backgrounds. These competed for genetically similar or dissimilar females in ratios of 1:1:3. We analyzed the effect of genetic similarity, transgenic state and stock on mating frequency. We observed no differences in the competitiveness of the wild and transgenic heterozygotes, no effect of genetic relatedness, nor a clear benefit of the out-crossing strategy to increase competitiveness. A decrease in the development rate of all phenotypic classes was observed among progeny of transgenic males but the rate of adult emergence of transgenic individuals was in most cases slightly faster than wild-type siblings. C1 [Howell, P. I.] Malaria Res & Reference Reagent Resource Ctr MR4, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Howell, P. I.] AREF, Atlanta, GA 30341 USA. RP Benedict, MQ (reprint author), IAEA, NAHU, Agcy Labs, A-2444 Seibersdorf, Austria. EM M.Benedict@iaea.org FU NIAID [N01-AI-85355] FX We appreciate the NIAID-funded contract N01-AI-85355 to the American Type Culture Collection and and its financial support in the operation of the MR4 and their cooperation in developing and implementing the subcontract to the CDC Foundation that makes this research possible. Special thanks to the donors of the mosquito stocks; without them these experiments would not have been possible: Maureen Coetzee (KGB), Badria Babiker El Sayed (DONGOLA), Herve Bossin and Janis Thailayil (DONG-GFP+). NR 38 TC 3 Z9 3 U1 1 U2 9 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0892-7553 J9 J INSECT BEHAV JI J. Insect Behav. PD NOV PY 2009 VL 22 IS 6 BP 477 EP 491 DI 10.1007/s10905-009-9187-y PG 15 WC Entomology SC Entomology GA 500SL UT WOS:000270324900005 ER PT J AU Hojgaard, A Biketov, SF Shtannikov, AV Zeidner, NS Piesman, J AF Hojgaard, Andrias Biketov, Sergey F. Shtannikov, Alexander V. Zeidner, Nordin S. Piesman, Joseph TI Molecular Identification of Salp15, a Key Salivary Gland Protein in the Transmission of Lyme Disease Spirochetes, From Ixodes persulcatus and Ixodes pacificus (Acari: Ixodidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ticks; salivary glands; Salp15; Lyme disease; Ixodes ID PATHWAY INHIBITOR TFPI; SCAPULARIS TICKS; RICINUS TICKS; CLONING; EXPRESSION; LIPOCALINS; COMPLEX; BINDING; VECTOR; FAMILY AB Salp15 is a multifunctional protein, vital to the tick in its need to obtain vertebrate host blood without stimulating a host inflammatory and immune response. The Salp15 protein from both Ixodes scapularis Say and Ixodes ricinus! (L.), the principal vectors of the Lyme disease spirochete in eastern North America and Europe, respectively, have been well characterized and found to bind the murine CD4 receptor, DC-SIGN, and the OspC protein of Borrelia burgdorferi. In the current study, we characterized the full salp15 gene in Ixodes pacificus Cooley & Kohls and Ixodespersulcatus Schulze, the principal vectors of Lyme disease spirochetes in western North America and Asia, respectively. In comparing the Salp15 protein of all four principal vector ticks of public health importance for the transmission of Lyme disease spirochetes, we find the 53 C-terminal amino acids to have a high degree of similarity. There are at least three clades in the tree of Salp15 and its homologues, probably representing a multigene family. C1 [Hojgaard, Andrias; Zeidner, Nordin S.; Piesman, Joseph] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, NCZVED, CCID, Ft Collins, CO 80521 USA. [Hojgaard, Andrias] FSU SRC Appl Microbiol & Biotechnol, Obolensk, Moscow Area, Russia. EM fth@cdc.gov NR 32 TC 13 Z9 13 U1 0 U2 4 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2009 VL 46 IS 6 BP 1458 EP 1463 DI 10.1603/033.046.0631 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 517CW UT WOS:000271591800031 PM 19960697 ER PT J AU Kalman, L Wilson, JA Buller, A Dixon, J Edelmann, L Geller, L Highsmith, WE Holtegaard, L Kornreich, R Rohlfs, EM Payeur, TL Sellers, T Toji, L Muralidharan, K AF Kalman, Lisa Wilson, Jean Amos Buller, Arlene Dixon, John Edelmann, Lisa Geller, Louis Highsmith, William Edward Holtegaard, Leonard Kornreich, Ruth Rohlfs, Elizabeth M. Payeur, Toby L. Sellers, Tina Toji, Lorraine Muralidharan, Kasinathan TI Development of Genomic DNA Reference Materials for Genetic Testing of Disorders Common in People of Ashkenazi Jewish Descent SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID MUCOLIPIDOSIS TYPE-IV; CARRIER-FREQUENCY; CANAVAN-DISEASE; CYSTIC-FIBROSIS; BLOOM-SYNDROME; POPULATION; MUTATION; RECOMMENDATIONS; DIAGNOSIS; ANEMIA AB Many recessive genetic disorders are found at a higher incidence in people of Ashkenazi Jewish (AJ) descent than in the general population. The American College of Medical Genetics and the American College of Obstetricians and Gynecologists have recommended that individuals of AJ descent undergo carrier screening for Tay Sachs disease, Canavan disease, familial dysautonomia, mucolipidosis IV, Niemann-Pick disease type A, Fanconi anemia type C, Bloom syndrome, and Gaucher disease. Although these recommendations have led to increased test volumes and number of laboratories offering AJ screening, well-characterized genomic reference materials are not publicly available. The Centers for Disease Control and Prevention-based Genetic Testing Reference Materials Coordination Program, in collaboration with members of the genetic testing community and Coriell Cell Repositories, have developed a panel of characterized genomic reference materials for AJ genetic testing. DNA from 31 cell lines, representing many of the common alleles for Tay Sachs disease, Canavan disease, familial dysautonomia, mucolipidosis W, Niemann-Pick disease type A, Fanconi anemia type C, Bloom syndrome, Gaucher disease, and glycogen storage disease, was prepared by the Repository and tested in six clinical laboratories using three different PCR-based assay platforms. A total of 33 disease alleles was assayed and 25 different alleles were identified. These characterized materials are publicly available from Coriell and may be used for quality control, proficiency testing, test development, and research. (J Mol Diagn 2009, 11:530-536; DOI: 10.2353/jmoldx.2009.090050) C1 [Kalman, Lisa] Ctr Dis Control & Prevent, Lab Practice Evaluat & Genom Branch, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [Wilson, Jean Amos; Geller, Louis] Focus Diagnost, Cyress, CA USA. [Buller, Arlene] Quest Diagnost Nichols Inst, San Juan Capistrano, CA USA. [Dixon, John; Muralidharan, Kasinathan] Emory Univ, Sch Med, Atlanta, GA USA. [Edelmann, Lisa; Kornreich, Ruth] Mt Sinai Sch Med, New York, NY USA. [Highsmith, William Edward; Holtegaard, Leonard] Mayo Clin, Rochester, MN USA. [Rohlfs, Elizabeth M.; Payeur, Toby L.] Genzyme Corp, Westborough, MA USA. [Sellers, Tina; Toji, Lorraine] Coriell Inst Med Res, Camden, NJ USA. RP Kalman, L (reprint author), Ctr Dis Control & Prevent, Lab Practice Evaluat & Genom Branch, Natl Ctr Preparedness Detect & Control Infect Dis, 1600 Clifton Rd,Mailstop G23, Atlanta, GA 30333 USA. EM LKalman@cdc.gov NR 36 TC 7 Z9 8 U1 0 U2 1 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2009 VL 11 IS 6 BP 530 EP 536 DI 10.2353/jmoldx.2009.090050 PG 7 WC Pathology SC Pathology GA 518HK UT WOS:000271681400006 PM 19815695 ER PT J AU Barker, SD Bale, S Booker, J Buller, A Das, S Friedman, K Godwin, AK Grody, WW Highsmith, E Kant, JA Lyon, E Mao, R Monaghan, KG Payne, DA Pratt, VM Schrijver, I Shrimpton, AE Spector, E Telatar, M Toji, L Weck, K Zehnbauer, B Kalman, LV AF Barker, Shannon D. Bale, Sherri Booker, Jessica Buller, Arlene Das, Soma Friedman, Kenneth Godwin, Andrew K. Grody, Wayne W. Highsmith, Edward Kant, Jeffery A. Lyon, Elaine Mao, Rong Monaghan, Kristin G. Payne, Deborah A. Pratt, Victoria M. Schrijver, Iris Shrimpton, Antony E. Spector, Elaine Telatar, Milhan Toji, Lorraine Weck, Karen Zehnbauer, Barbara Kalman, Lisa V. TI Development and Characterization of Reference Materials for MTHFR, SERPINA1, RET, BRCA1, and BRCA2 Genetic Testing SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID POLYMERASE-CHAIN-REACTION; GENOMIC REFERENCE MATERIALS; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; ALPHA(1)-ANTITRYPSIN DEFICIENCY; ALPHA-1-ANTITRYPSIN DEFICIENCY; CARDIOVASCULAR-DISEASE; PRENATAL-DIAGNOSIS; QUALITY-ASSURANCE; POINT MUTATION; BREAST-CANCER AB Well-characterized reference materials (RMs) are integral in maintaining clinical laboratory quality assurance for genetic testing. These RMs can be used for quality control, monitoring of test performance, test validation, and proficiency testing of DNA-based genetic tests. To address the need for such materials, the Centers for Disease Control and Prevention established the Genetic Testing Reference Material Coordination Program (GeT-RM), which works with the genetics community to improve public availability of characterized RMs for genetic testing. To date, the GeT-RM program has coordinated the characterization of publicly available genomic DNA RMs for a number of disorders, including cystic fibrosis, Huntington disease, fragile X, and several genetic conditions with relatively high prevalence in the Ashkenazi Jewish population. Genotypic information about a number of other cell lines has been collected and is also available. The present study includes the development and commutability/genotype characterization of 10 DNA samples for clinically relevant mutations or sequence variants in the following genes: MTHFR; SERPINA1; RET; BRCA1; and BRCA2. DNA samples were analyzed by 19 clinical genetic laboratories using a variety of assays and technology platforms. Concordance was 100% for all samples, with no differences observed between laboratories using different methods. All DNA samples are available from Coriell Cell Repositories and characterization information can he found on the GeT-RM website. (J Mol Diagn 2009, 11:553-561; DOI: 10.2353/jmoldx.2009.090078) C1 [Barker, Shannon D.; Kalman, Lisa V.] Ctr Dis Control & Prevent, Div Lab Syst, Atlanta, GA USA. [Bale, Sherri] GeneDx Inc, Gaithersburg, MD USA. [Booker, Jessica; Weck, Karen] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA. [Buller, Arlene] Quest Diagnost, Mol Genet, San Juan Capistrano, CA USA. [Das, Soma] Univ Chicago, Dept Genet, Chicago, IL 60637 USA. [Friedman, Kenneth] LabCorp, Burlington, NC USA. [Godwin, Andrew K.] Fox Chase Canc Ctr, Clin Mol Genet Lab, Philadelphia, PA 19111 USA. [Grody, Wayne W.] Univ Calif Los Angeles, Div Med Genet, Los Angeles, CA USA. [Grody, Wayne W.] Univ Calif Los Angeles, Div Mol Pathol, Los Angeles, CA USA. [Highsmith, Edward] Mayo Clin, Dept Lab Genet, Rochester, MN USA. [Kant, Jeffery A.] Univ Pittsburgh, Dept Pathol & Human Genet, Pittsburgh, PA USA. [Lyon, Elaine; Mao, Rong] Univ Utah, Dept Pathol, Salt Lake City, UT USA. [Lyon, Elaine; Mao, Rong] Univ Utah, ARUP Labs, Salt Lake City, UT USA. [Monaghan, Kristin G.] Henry Ford Hosp, DNA Diagnost Lab, Detroit, MI 48202 USA. [Payne, Deborah A.] Univ Texas Dallas, SW Med Ctr, Dept Pathol, Dallas, TX USA. [Pratt, Victoria M.] Quest Diagnost, Nichols Inst, Chantilly, VA USA. [Schrijver, Iris] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA. [Shrimpton, Antony E.] SUNY Upstate Med Univ, Dept Clin Pathol, Syracuse, NY USA. [Spector, Elaine] Univ Colorado, Sch Med, Dept Pediat, Div Med Genet, Aurora, CO USA. [Telatar, Milhan] Specialty Labs, Valencia, CA USA. [Toji, Lorraine] Coriell Inst Med Res, Camden, NJ USA. [Zehnbauer, Barbara] Washington Univ, Sch Med, Dept Pathol, St Louis, MO USA. [Zehnbauer, Barbara] Washington Univ, Sch Med, Dept Immunol & Pediat, St Louis, MO USA. RP Barker, SD (reprint author), 1600 Clifton Rd NE,G23, Atlanta, GA 30329 USA. EM sbarker@cdc.gov OI Weck, Karen/0000-0002-8516-333X FU Association for Prevention Teaching and Research; Centers for Disease Control and Prevention [U50/CCU300860]; Ovarian Cancer SPORE at Fox Chase Cancer Center [P50 CA083638] FX Supported by a cooperative agreement between the Association for Prevention Teaching and Research and the Centers for Disease Control and Prevention (award number U50/CCU300860); and the Ovarian Cancer SPORE at Fox Chase Cancer Center (P50 CA083638). NR 51 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2009 VL 11 IS 6 BP 553 EP 561 DI 10.2353/jmoldx.2009.090078 PG 9 WC Pathology SC Pathology GA 518HK UT WOS:000271681400009 PM 19767587 ER PT J AU Kalman, L Zehnbauer, B Wilson, JA Baak, R Babic, N Bettinotti, M Buller, A Butz, K Campbell, M Civalier, C El-Badry, A Farkas, DH Lyon, E McKinney, J Muralidharan, K Noll, L Mandal, S Sander, T Shabbeer, J Smith, C Telatar, M Toji, L Vairavan, A Vance, C Weck, K Wu, A Yeo, KJ Zeller, M Pratt, VM AF Kalman, L. Zehnbauer, B. Wilson, J. Amos Baak, R. Babic, N. Bettinotti, M. Buller, A. Butz, K. Campbell, M. Civalier, C. El-Badry, A. Farkas, D. H. Lyon, E. McKinney, J. Muralidharan, K. Noll, L. Mandal, S. Sander, T. Shabbeer, J. Smith, C. Telatar, M. Toji, L. Vairavan, A. Vance, C. Weck, K. Wu, A. Yeo, K. J. Zeller, M. Pratt, V. M. TI Characterization of 107 Genomic DNA Reference Materials for Five Common Pharmacogenetic Loci (CYP2D6, CYP2C9, VKORC1, CYP2C19 and UGT1A1): A GeT-RM Collaborative Project SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Molecular-Pathology CY NOV 19-22, 2009 CL Orlando, FL SP Assoc Mole Pathol C1 [Kalman, L.] Ctr Dis Control & Prevent, NCPDCID DLS, Atlanta, GA USA. [Zehnbauer, B.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA. [Zehnbauer, B.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA. [Wilson, J. Amos; Shabbeer, J.] Berkeley HeartLab Inc, Alameda, CA USA. [Baak, R.; El-Badry, A.; Smith, C.; Zeller, M.] AutoGenomics Inc, Res & Dev, Carlsbad, CA USA. [Babic, N.; Yeo, K. J.] Univ Chicago, Clin Pharmacogenom Program, Chicago, IL 60637 USA. [Bettinotti, M.] Quest Diagnost Nichols Inst, HLA, Chantilly, VA USA. [Bettinotti, M.] Quest Diagnost Nichols Inst, Immunogenet Dept, Chantilly, VA USA. [Buller, A.] Quest Diagnost, Mol Genet, San Juan Capistrano, CA USA. [Butz, K.] ParagonDx LLC, Morrisville, NC USA. [Lyon, E.] Univ Utah ARUP, ARUP Labs, Salt Lake City, UT USA. [Civalier, C.; Weck, K.] Univ N Carolina, Pathol & Lab Med, Chapel Hill, NC USA. [Farkas, D. H.] Sequenom Ctr Mol Med, Grand Rapids, MI USA. [McKinney, J.] Idaho Technol Inc, Div Life Sci, Salt Lake City, UT USA. [Noll, L.; Sander, T.] Childrens Hosp Wisconsin, Pathol & Lab Med, Milwaukee, WI 53201 USA. [Mandal, S.] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA. [Telatar, M.] Specialty Labs Inc, Mol Genet, Valencia, CA USA. [Toji, L.] Coriell Cell Repositories, Camden, NJ USA. [Vairavan, A.] AutoGenomics Inc, Business Dev, Carlsbad, CA USA. [Wu, A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2009 VL 11 IS 6 BP 625 EP 626 PG 2 WC Pathology SC Pathology GA 518HK UT WOS:000271681400052 ER PT J AU Pratt, V Zehnbauer, B Babic, N Buller, A Butz, K Campbell, M Farkas, DH Lyon, E Mandal, S Muralidharan, K Toji, L Vance, C Yeo, KJ Kalman, L AF Pratt, V. Zehnbauer, B. Babic, N. Buller, A. Butz, K. Campbell, M. Farkas, D. H. Lyon, E. Mandal, S. Muralidharan, K. Toji, L. Vance, C. Yeo, K. J. Kalman, L. TI Characterization of 107 Genomic DNA Reference Materials for CYP2D6: A GeT-RM Collaborative Project SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Molecular-Pathology CY NOV 19-22, 2009 CL Orlando, FL SP Assoc Mole Pathol C1 [Pratt, V.; Buller, A.; Muralidharan, K.] Quest Diagnost Nichols Inst, Mol Genet, Chantilly, VA USA. [Zehnbauer, B.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA. [Zehnbauer, B.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA. [Babic, N.; Yeo, K. J.] Univ Chicago, Clin Pharmacogenom Program, Chicago, IL 60637 USA. [Butz, K.] ParagonDx LLC, Morrisville, NC USA. [Lyon, E.] Univ Utah ARUP, ARUP Labs, Salt Lake City, UT USA. [Farkas, D. H.] Sequenom Ctr Mol Med, Grand Rapids, MI USA. [Mandal, S.] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA. [Toji, L.] Coriell Cell Repositories, Camden, NJ USA. [Kalman, L.] Ctr Dis Control & Prevent, NCPDCID, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2009 VL 11 IS 6 BP 626 EP 626 PG 1 WC Pathology SC Pathology GA 518HK UT WOS:000271681400053 ER PT J AU Zehnbauer, B Pratt, VM Baak, R Babic, N Buller, A El-Badry, A Mandal, S McKinney, J Muralidharan, K Noll, L Sander, T Telatar, M Toji, L Vairavan, A Yeo, K Zeller, M Kalman, L AF Zehnbauer, B. Pratt, V. M. Baak, R. Babic, N. Buller, A. El-Badry, A. Mandal, S. McKinney, J. Muralidharan, K. Noll, L. Sander, T. Telatar, M. Toji, L. Vairavan, A. Yeo, K. Zeller, M. Kalman, L. TI Characterization of 107 Genomic DNA Reference Materials for Warfarin-Sensitivity Pharmacogenetic Testing SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Molecular-Pathology CY NOV 19-22, 2009 CL Orlando, FL SP Assoc Mole Pathol C1 [Zehnbauer, B.] Washington Univ, Sch Med, St Louis, MO USA. [Pratt, V. M.; Buller, A.; Muralidharan, K.] Quest Diagnost Nichols Inst, Chantilly, VA USA. [Baak, R.; El-Badry, A.; Zeller, M.] AutoGenomics Inc, Res & Dev, Carlsbad, CA USA. [Babic, N.; Yeo, K.] Univ Chicago, Clin Pharmacogenom Program, Chicago, IL 60637 USA. [McKinney, J.] Idaho Technol Inc, Div Life Sci, Salt Lake City, UT USA. [Noll, L.; Sander, T.] Childrens Hosp Wisconsin, Pathol & Lab Med, Milwaukee, WI 53201 USA. [Telatar, M.] Specialty Labs Inc, Mol Genet, Valencia, CA USA. [Toji, L.] Coriell Inst Med Res, Camden, NJ USA. [Vairavan, A.] AutoGenomics Inc, Business Dev, Carlsbad, CA USA. [Kalman, L.] Ctr Dis Control & Prevent, NCPDCID, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2009 VL 11 IS 6 BP 626 EP 626 PG 1 WC Pathology SC Pathology GA 518HK UT WOS:000271681400054 ER PT J AU Petitti, DB Klingensmith, GJ Bell, RA Andrews, JS Dabelea, D Imperatore, G Marcovina, S Pihoker, C Standiford, D Waitzfelder, B Mayer-Davis, E AF Petitti, Diana B. Klingensmith, Georgeanna J. Bell, Ronny A. Andrews, Jeanette S. Dabelea, Dana Imperatore, Giuseppina Marcovina, Santica Pihoker, Catherine Standiford, Debra Waitzfelder, Beth Mayer-Davis, Elizabeth CA SEARCH Diabet Youth Study Grp TI Glycemic Control in Youth with Diabetes: The SEARCH for Diabetes in Youth Study SO JOURNAL OF PEDIATRICS LA English DT Article ID BLOOD-GLUCOSE CONTROL; CARDIOVASCULAR-DISEASE; INTENSIVE TREATMENT; FOLLOW-UP; CHILDREN; ADOLESCENTS; MELLITUS; COMPLICATIONS; TRIAL; CARE AB Objective To assess correlates of glycemic control in a diverse population of children and youth with diabetes. Study design This was a cross-sectional analysis of data from a 6-center US study of diabetes in youth, including 3947 individuals with type 1 diabetes (T1D) and 552 with type 2 diabetes (T2D), using hemoglobin A(1c) (HbA(1c)) levels to assess glycemic control. Results HbA(1c) levels reflecting poor glycemic control (HbA(1c) >= 9.5%) were found in 17% of youth with T1D and in 27% of those with T2D. African-American, American Indian, Hispanic, and Asian/Pacific Islander youth with T1D were significantly more likely to have higher HbA(1c) levels compared with non-Hispanic white youth (with respective rates for poor glycemic control of 36%, 52%, 27%, and 26% vs 12%). Similarly poor control in these 4 racial/ethnic groups was found in youth with T2D. Longer duration of diabetes was significantly asso*ciated with poorer glycemic control in youth with T1D and T2D. Conclusions The high percentage of US youth with HbA(1c) levels above the target value and with poor glycemic control indicates an urgent need for effective treatment strategies to improve metabolic status in youth with diabetes. (J Pediatr 2009; 155: 668-72). C1 [Bell, Ronny A.] Wake Forest Univ, Bowman Gray Sch Med, SEARCH Coordinating Ctr, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA. [Petitti, Diana B.] Arizona State Univ, Phoenix, AZ USA. [Klingensmith, Georgeanna J.] Univ Colorado, Barbara Davis Ctr Childhood Diabet, Pediat Clin, Denver, CO 80202 USA. [Klingensmith, Georgeanna J.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. [Andrews, Jeanette S.] Wake Forest Univ Hlth Sci, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC USA. [Dabelea, Dana] Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Marcovina, Santica] Univ Washington, Dept Med, Seattle, WA USA. [Pihoker, Catherine] Childrens Hosp, Div Endocrinol & Diabet, Seattle, WA USA. [Pihoker, Catherine] Reg Med Ctr, Seattle, WA USA. [Standiford, Debra] Childrens Hosp, Med Ctr, Div Endocrinol, Cincinnati, OH 45229 USA. [Waitzfelder, Beth] Pacific Hlth Res Inst, Honolulu, HI USA. [Mayer-Davis, Elizabeth] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Mayer-Davis, Elizabeth] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. RP Bell, RA (reprint author), Wake Forest Univ, Bowman Gray Sch Med, SEARCH Coordinating Ctr, Dept Epidemiol & Prevent, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM rbell@wfubmc.edu OI McKeown, Robert/0000-0002-8829-5784 FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) FX The SEARCH for Diabetes in Youth Study is funded by the Centers for Disease Control and Prevention (CDC) ( PA number 00097 and DP-05-069) and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Site contract numbers are as follows: Kaiser Permanente Southern California, U01 DP000246; University of Colorado Health Sciences Center, U01 DP000247; Pacific Health Research Institute, U01 DP000245; Children's Hospital Medical Center ( Cincinnati), U01 DP000248; University of North Carolina at Chapel Hill, U01 DP000254; University of Washington (ASCP), and Malaka Jackson, MD for the University of South Carolina; Lynne Hartel, MA, Yaw Appiagyei-Dankah, MD, and Lyndon Key, MD, for the Medical University of South Carolina; Sheree Mejia, RN, James Amrhein, MD, and Kent Reifschneider, MD, for Greenville Hospital Systems; Pam Clark, MDfor McLeod Pediatric Subspecialists; Mark Parker, MD for Pediatric Endocrinology & Diabetes Specialists; and I. David Schwartz, MD for Pediatric Endocrinology at the Medical College of Georgia NR 34 TC 124 Z9 133 U1 1 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD NOV PY 2009 VL 155 IS 5 BP 668 EP U107 DI 10.1016/j.jpeds.2009.05.025 PG 8 WC Pediatrics SC Pediatrics GA 516VH UT WOS:000271570900016 PM 19643434 ER PT J AU Kaminski, JW Fang, XM AF Kaminski, Jennifer Wyatt Fang, Xiangming TI Victimization by Peers and Adolescent Suicide in Three US Samples SO JOURNAL OF PEDIATRICS LA English DT Article ID SCHOOL-CHILDREN; YOUTH SUICIDE; VIOLENT BEHAVIORS; RISK; HEALTH; DEPRESSION; SYMPTOMS; STUDENTS; IDEATION; VICTIMS AB Objective To investigate the association between victimization by peers and suicidal ideation and behavior in 3 samples of adolescents in the United States. Study design This study was a secondary analysis of data from 3 cohorts of adolescents: (1) a nationally representative survey of adolescents in grade 7 through 12, Wave I of the National Longitudinal Study of Adolescent Health, conducted by the Carolina Population Center in 1994-1995; (2) a nationally representative survey, the Youth Risk Behavior Surveillance System, conducted by the Centers for Disease Control and Prevention in 2005; and (3) a survey in a high-risk community conducted by the Centers for Disease Control and Prevention in 2004. Results Controlling for differences in age, sex, race/ethnicity, and depressive symptomology, adolescents reporting more frequent victimization by peers were more likely to report suicidal ideation and suicidal behavior. Adjusted odds ratios ranged from 1.67 (95% confidence interval [CI] = 1.30-2.15) to 3.83 (95% CI = 2.78-5.27) for the different outcome measures and data sets. Conclusions Our results provide further support for the need for effective prevention of peer victimization. Inclusion of questions about victimization experiences might aid formal and informal suicide screening efforts. (J Pediatr 2009; 155: 683-8). C1 [Kaminski, Jennifer Wyatt; Fang, Xiangming] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA 30341 USA. RP Kaminski, JW (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, 4770 Buford Hwy NE,MS F64, Atlanta, GA 30341 USA. EM JKaminski@cdc.gov RI Fang, Xiangming/O-1653-2014 OI Fang, Xiangming/0000-0001-9922-8977 FU Eunice Kennedy Shriver National Institute of Child Health and Human Development [P01-HD31921] FX This research used data from Add Health, a program project designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris and funded by Grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. No direct support for this analysis was received from Grant P01-HD31921. Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle for their assistance with the original design. Persons interested in obtaining data files from Add Health should contact Add Health, Carolina Population Center, 123 West Franklin Street, Chapel Hill, NC 27516-2524 (addhealth@unc.edu). NR 36 TC 40 Z9 40 U1 0 U2 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD NOV PY 2009 VL 155 IS 5 BP 683 EP 688 DI 10.1016/j.jpeds.2009.04.061 PG 6 WC Pediatrics SC Pediatrics GA 516VH UT WOS:000271570900019 PM 19616788 ER PT J AU Kimber, C Abercrombie, E Epping, JN Mordecai, L Newkirk, J Ray, M AF Kimber, Christine Abercrombie, Eydie Epping, Jacqueline N. Mordecai, LeeAnn Newkirk, Jimmy, Jr. Ray, Michael TI Elevating Physical Activity as a Public Health Priority: Creation of the National Society of Physical Activity Practitioners in Public Health SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE chronic disease; health promotion; physical activity AB Background: Physical activity has emerged as a distinct area of public health practice. As this field evolved, the need for a professional organization for physical activity practitioners in public health became evident. A collaboration of several existing public health professional organizations formed to address this new area of public health practice. The collaboration laid the foundation to establish a professional organization. National Association of Physical Activity Practitioners in Public Health (NSPAPPH) was launched in April 2006. NSPAPPH accomplishments to date include convening a national meeting of physical activity practitioners, conducting strategic planning, adopting bylaws and core competencies for professional practice, developing a website and electronic newsletter, and establishing training opportunities for practitioners. Conclusions: Future plans for NSPAPPH include development of a professional certification for physical activity practitioners in public health; enhancement of training and professional development opportunities; recruitment of members from national, tribal, state, and local organizations working in public and private sectors; publications of journal articles, reports, and issue briefs; and development of a policy agenda. Implementing these plans will serve to strengthen public health infrastructure for physical activity, thus improving the physical activity behaviors of Americans and the health of the nation. C1 [Kimber, Christine] Minnesota Dept Hlth, Chron Dis Risk Reduct Unit, St Paul, MN USA. [Abercrombie, Eydie] Arkansas Dept Hlth, Benton, AR USA. [Epping, Jacqueline N.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Mordecai, LeeAnn] Directors Hlth Promot & Educ, Madison, MS USA. [Newkirk, Jimmy, Jr.] N Carolina Div Publ Hlth, Phys Act & Nutr Branch, Raleigh, NC USA. [Ray, Michael] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA. RP Kimber, C (reprint author), Minnesota Dept Hlth, Chron Dis Risk Reduct Unit, St Paul, MN USA. NR 5 TC 4 Z9 5 U1 0 U2 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD NOV PY 2009 VL 6 IS 6 BP 677 EP 681 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 662VJ UT WOS:000282842100001 PM 20101909 ER PT J AU Bornstein, DB Pate, RR Pratt, M AF Bornstein, Daniel Benjamin Pate, Russell R. Pratt, Michael TI A Review of the National Physical Activity Plans of Six Countries SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Review DE physical activity plan; physical activity policy; National Physical Activity Plan AB Background: Architects of the United States national physical activity plan can benefit from a thorough understanding of national physical activity plans from other nations. The purpose of this paper was to search for and analyze comprehensive national physical activity plan documents that can best inform the development of the U.S. plan. Methods: Electronic databases were searched for national physical activity plan documents, yielding 252 documents from 56 countries. After eliminating documents that were not written in English, did not address physical activity primarily, and did not meet our definition of a national physical activity plan, we were left with physical activity plans from 6 countries-Australia, United Kingdom, Scotland, Sweden, Northern Ireland, and Norway. Key recommendations: Architects of the U.S. plan can learn as much from what was present in many documents as from what was absent. Examples of recommended components of national plans have been identified and highlighted for each of the 6 countries. Missing from all but 1 national plan document was a detailed process for accountability. Providing a clear path and detailed process of accountability will assist greatly in measuring short- and long-term success of the U.S. plan. C1 [Bornstein, Daniel Benjamin; Pate, Russell R.] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. [Pratt, Michael] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Atlanta, GA USA. RP Bornstein, DB (reprint author), Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. NR 10 TC 20 Z9 21 U1 1 U2 3 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD NOV PY 2009 VL 6 SU 2 BP S245 EP S264 PG 20 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 662VK UT WOS:000282842200010 PM 20120133 ER PT J AU Patrick, K Pratt, M Sallis, RE AF Patrick, Kevin Pratt, Michael Sallis, Robert E. TI The Healthcare Sector's Role in the US National Physical Activity Plan SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE medical care; clinical preventive services; exercise counseling ID RANDOMIZED CONTROLLED-TRIAL; COST-EFFECTIVENESS; AMERICAN-COLLEGE; GENERAL-PRACTICE; EXERCISE; ADVICE; INTERVENTION; PREVENTION; MODEL; PRESCRIPTION AB Background: Healthcare professionals are influential sources of health information and guidance for people of all ages. However healthcare providers do not routinely address physical activity (PA). Engaging health professionals in a national plan for physical activity will depend upon whether proven strategies can be found to promote PA within clinical settings. Methods: The literature on promoting PA in healthcare settings was reviewed, as were recommendations from healthcare organizations and evidence-gathering entities about whether and how PA should be promoted in healthcare. Key recommendations: Evidence is mixed about whether interventions based in healthcare settings and offered by healthcare providers can improve PA behaviors in patients. Brief stand-alone counseling by physicians has not been shown to be efficacious, but office-based screening and advice to be active, followed by telephone or community support for PA has proven effective in creating lasting PA behavior improvement. Healthcare delivery models that optimize the organization of services across clinical and community resources may be very compatible with PA promotion in health care. Because of the importance of PA to health, healthcare providers are encouraged to consider adding PA as a vital sign for each medical visit for individuals aged 6 years and older. C1 [Patrick, Kevin] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Pratt, Michael] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Atlanta, GA USA. [Sallis, Robert E.] Univ Calif Riverside, Dept Family Med, Fontana, CA USA. RP Patrick, K (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. NR 58 TC 21 Z9 23 U1 0 U2 7 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 EI 1543-5474 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD NOV PY 2009 VL 6 SU 2 BP S211 EP S219 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 662VK UT WOS:000282842200007 PM 20120130 ER PT J AU Brookmeyer, KA Henrich, CC AF Brookmeyer, Kathryn A. Henrich, Christopher C. TI Disentangling Adolescent Pathways of Sexual Risk Taking SO JOURNAL OF PRIMARY PREVENTION LA English DT Article DE Adolescence; Risk taking; Sexual risk; Latent class growth analyses ID ANALYZING DEVELOPMENTAL TRAJECTORIES; SUBSTANCE USE; PROBLEM BEHAVIORS; YOUNG ADULTHOOD; DELINQUENCY; PREDICTORS; ALCOHOL; SAMPLE; MODEL; COOCCURRENCE AB Using data from the National Longitudinal Survey of Youth, the authors aimed to describe the pathways of risk within sexual risk taking, alcohol use, and delinquency, and then identify how the trajectory of sexual risk is linked to alcohol use and delinquency. Risk trajectories were measured with adolescents aged 15-24 years (N = 1,778). Using Latent Class Growth Analyses (LCGA), models indicated that the majority of adolescents engaged in sexual risk and alcohol use. In joint trajectory analyses, LCGA revealed six risk taking classes: sex and alcohol, moderate risk taking, joint risk taking, moderate alcohol, alcohol risk, and alcohol and delinquency experimentation. Editors' Strategic Implications: School administrators and curriculum designers should pay attention to the study's findings with respect to the need for prevention programs to target early adolescents and integrate prevention messages about alcohol use and sexual risk taking. C1 [Brookmeyer, Kathryn A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Henrich, Christopher C.] Georgia State Univ, Atlanta, GA 30303 USA. RP Brookmeyer, KA (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM KBrookmeyer@cdc.gov; Chenrich@gsu.edu NR 52 TC 13 Z9 13 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0278-095X J9 J PRIM PREV JI J. Prim. Prev. PD NOV PY 2009 VL 30 IS 6 BP 677 EP 696 DI 10.1007/s10935-009-0196-6 PG 20 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 646AH UT WOS:000281506800004 PM 19949869 ER PT J AU Kolasa, MS Lutz, JR Cofsky, A Jones, T AF Kolasa, Maureen S. Lutz, James R. Cofsky, Abbey Jones, Tanya TI Provider Chart Audits and Outreach to Parents: Impact in Improving Childhood Immunization Coverage and Immunization Information System Completeness SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE immunization; health services; registries; vaccination ID INFLUENZA VACCINATION; CHILDREN; INTERVENTIONS; REGISTRIES; RECALL AB Objective: Examine impact of provider chart audits and parental outreach in improving immunization coverage among children not up-to-date (NUTD) for immunizations in Philadelphia's immunization information system (IIS). Methods: We identified 10-month-old children NUTD for age-appropriate immunizations using Philadelphia's IIS. Immunization rates at 10, 13, and 19 months were compared before and after contact with providers and parents. Results: Of 5 610 children NUTD in the IIS at 10 months and living in areas with populations at risk for underimmunization, provider chart audits indicated that 3 612 (64%) were actually up-to-date (UTD); the majority of these (2 203) received additional age-appropriate immunizations and were also UTD at 19 months. Of 1998 children truly NUTD at 10 months, half received overdue immunizations by 13 months following contact with parents via telephone, postcards, and home visits, but only 23 percent were UTD for age-appropriate vaccines at 19 months. Conclusions: Provider chart audits improved IIS data completeness, indicating that providers need to submit more complete and timely data to the IIS. Outreach to parents likely contributed to half of the children NUTD at 10 months receiving overdue immunizations by 13 months. However, most were again NUTD at 19 months, indicating that outreach efforts should be continued through 19 months or until children are brought UTD. Furthermore, in spite of outreach, about half of the NUTD children were not brought UTD by 13 or 19 months. New strategies should be developed to ensure that these children receive recommended vaccinations. C1 [Kolasa, Maureen S.] Ctr Dis Control & Prevent, Hlth Serv Res & Evaluat Branch, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Lutz, James R.] Ctr Dis Control & Prevent, Program Operat Branch, Natl Ctr Immunizat & Resp Dis, Philadelphia, PA USA. [Cofsky, Abbey] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA. [Jones, Tanya] Philadelphia Dept Publ Hlth, Div Dis Control, Philadelphia, PA USA. RP Kolasa, MS (reprint author), Ctr Dis Control & Prevent, Hlth Serv Res & Evaluat Branch, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mail Stop E-52, Atlanta, GA 30333 USA. EM mkolasa@cdc.gov NR 14 TC 6 Z9 6 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV-DEC PY 2009 VL 15 IS 6 BP 459 EP 463 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TJ UT WOS:000271114700003 PM 19823149 ER PT J AU Crawford, CAG Summerfelt, WT Roy, K Chen, Z Meltzer, DO Thacker, SB AF Crawford, Carol A. Gotway Summerfelt, Wm Thomas Roy, Kakoli Chen, Zhuo (Adam) Meltzer, David O. Thacker, Stephen B. TI Perspectives on Public Health Workforce Research SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE Centers for Disease Control and Prevention; public health; social sciences; workforce ID PREPAREDNESS; CHALLENGES AB The Centers for Disease Control and Prevention Office of Workforce and Career Development is committed to developing a competent, sustainable, and diverse public health workforce through evidence-based training, career and leadership development, and strategic workforce planning to improve population health outcomes. This article reviews the previous efforts in identifying priorities of public health workforce research, which are summarized as eight major research themes. We outline a strategic framework for public health workforce research that includes six functional areas (le, definition and standards, data, methodology, evaluation, policy, and dissemination and translation). To conceptualize and prioritize development of an actionable public health research agenda, we constructed a matrix of key challenges in workforce analysis by public health workforce categories. Extensive reviews were conducted to identify valuable methods, models, and approaches to public health workforce research. We explore new tools and approaches for addressing priority areas for public health workforce and career development research and assess how tools from multiple disciplines of social sciences can guide the development of a research framework for advancing public health workforce research and policy. C1 [Crawford, Carol A. Gotway; Roy, Kakoli; Chen, Zhuo (Adam); Thacker, Stephen B.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Summerfelt, Wm Thomas] Advocate Hlth Care, Chicago, IL USA. [Meltzer, David O.] Univ Chicago, Dept Med & Econ, Chicago, IL 60637 USA. [Meltzer, David O.] Univ Chicago, Grad Sch Publ Policy, Chicago, IL 60637 USA. RP Crawford, CAG (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd,NE,MS E-94, Atlanta, GA 30333 USA. EM cdg7@cdc.gov RI Meltzer, David/C-2926-2009 OI Meltzer, David/0000-0003-2790-7393 NR 29 TC 8 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV PY 2009 BP S5 EP S15 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TK UT WOS:000271114800003 ER PT J AU Popovic, T AF Popovic, Tanja TI Workforce Science: A Critical Component to Ensuring Future of Health SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Popovic, T (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM TPopovic@cdc.gov NR 0 TC 1 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV PY 2009 BP S3 EP S4 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TK UT WOS:000271114800002 PM 19829225 ER PT J AU Roy, K Chen, Z Crawford, CAG AF Roy, Kakoli Chen, Zhuo (Adam) Crawford, Carol A. Gotway TI Economic Perspective on Strategic Human Capital Management and Planning for the Centers for Disease Control and Prevention SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE human capital management; personnel economics ID ORGANIZATIONS; INCENTIVES; GENDER; MOTIVATION; PROMOTIONS; PRIVATE AB An organization's workforce-or human capital-is its most valuable asset. The 2002 President's Management Agenda emphasizes the importance of strategic human capital management by requiring all federal agencies to improve performance by enhancing personnel and compensation systems. In response to these directives, the Centers for Disease Control and Prevention (CDC) drafted its strategic human capital management plan to ensure that it is aligned strategically to support the agency's mission and its health protection goals. In this article, we explore the personnel economics literature to draw lessons from research studies that can help CDC enhance its human capital management and planning. To do so, we focus on topics that are of practical importance and empirical relevance to CDC's internal workforce and personnel needs with an emphasis on identifying promising research issues or methodological approaches. The personnel economics literature is rich with theoretically sound and empirically rigorous approaches for shaping an evidence-based approach to human capital management that can enhance incentives to attract, retain, and motivate a talented federal public health workforce, thereby promoting the culture of high-performance government. C1 [Roy, Kakoli; Chen, Zhuo (Adam); Crawford, Carol A. Gotway] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Roy, K (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd NE,MS E94, Atlanta, GA 30333 USA. EM kjr_3@cdc.gov NR 42 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV PY 2009 BP S79 EP S89 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TK UT WOS:000271114800018 ER PT J AU Summerfelt, WT Tilson, HH Crawford, CAG AF Summerfelt, Wm Thomas Tilson, Hugh H. Crawford, Carol A. Gotway TI Moving Forward With Workforce Development Research in Public Health SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 [Summerfelt, Wm Thomas] Univ Chicago, Ctr Hlth & Social Sci, Chicago, IL 60637 USA. [Tilson, Hugh H.] UNC Sch Publ Hlth, Chapel Hill, NC USA. [Crawford, Carol A. Gotway] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA. RP Summerfelt, WT (reprint author), 205 W Touhy Ave, Park Ridge, IL 60068 USA. EM William.summerfelt@advocatehealth.com NR 4 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV PY 2009 BP S1 EP S2 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TK UT WOS:000271114800001 ER PT J AU Thacker, SB AF Thacker, Stephen B. TI Guide for Applied Public Health Workforce Research: An Evidence-Based Approach to Workforce Development SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material DE evidence-based public health; public health policy; public health workforce; recruitment; retention; training; workforce development; workforce research ID COMMUNITY-PREVENTIVE-SERVICES AB Essential to achievement of the public health mission is a knowledgeable, competent, and prepared workforce; yet, there is little application of science and technical knowledge to ensuring the effectiveness of that workforce, be it governmental or private. In this article, I review the evidence for effective workforce development and argue for an increased emphasis on an evidence-based approach to ensuring an effective workforce by encouraging the generation of the evidence base that is required. To achieve this, I propose the appointment of an independent Task Force on Public Health Workforce Practice to oversee the development of a Guide for Public Health Workforce Research and Practice (Workforce Guide), a process that will generate and bring together the workforce evidence base for use by public health practitioners. C1 Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Thacker, SB (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd,MS E-94, Atlanta, GA 30333 USA. EM sbt1@cdc.gov NR 20 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD NOV PY 2009 BP S109 EP S112 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 510TK UT WOS:000271114800023 ER PT J AU Cisternas, MG Murphy, LB Yelin, EH Foreman, AJ Pasta, DJ Helmick, CG AF Cisternas, Miriam G. Murphy, Louise B. Yelin, Edward H. Foreman, Aimee J. Pasta, David J. Helmick, Charles G. TI Trends in Medical Care Expenditures of US Adults with Arthritis and Other Rheumatic Conditions 1997 to 2005 SO JOURNAL OF RHEUMATOLOGY LA English DT Article DE ECONOMICS; COMORBIDITY; ARTHRITIS; COST; EXPENDITURES ID EARNINGS LOSSES; OSTEOARTHRITIS; PREVALENCE AB Objective. To examine trends in annual medical expenditures from 1997 to 2005 among adults with arthritis and other rheumatic conditions (denoted Arthritis group). Methods. We analyzed annual medical expenditures (2005 US dollars) among adults with Arthritis using the Medical Expenditure Panel Survey (MEPS), a nationally representative survey of the US civilian, noninstitutionalized Population. Expenditures were stratified by Arthritis and comorbidity status. Results. The Arthritis population increased by 22% (36.8 to 44.9 million) during this period, attributable entirely to the subpopulation with at least one comorbid condition (31.8 to 40.3 million). The overall, inflation-adjusted annual mean medical expenditures for adults with Arthritis increased from $6,848 in 1997 to $7,854 in 2005. In 1997, inpatient care was the most expensive component of overall expenditures (mean $2,702), but beginning, in 2001, mean inpatient and ambulatory expenditures were almost identical. Mean prescription expenditures increased nearly every year, almost doubling from $970 in 1997 to $1,811 in 2005. Aggregate total expenditures for the Arthritis Population increased markedly during this period, from $252.0 to $353.0 billion (+40%). Most of this increase was attributable to the population increase in the Arthritis and comorbid condition subgroup. Conclusion. Mean annual ambulatory and prescription expenditures for adults with Arthritis increased far above the rate of medical inflation, offsetting a relative decline in inpatient expenditures. Increases in overall mean and aggregate total expenditures are attributable to the increasing number of adults with Arthritis and at least one comorbid chronic condition. Projected increases in this Population suggest that these expenditures will continue to rise. (First Release Oct 1 2009; J Rheumatol 2009;36:253 1-8; doi: 10.3899/jrheum.081068) C1 [Cisternas, Miriam G.] MGC Data Serv, Carlsbad, CA 92008 USA. [Yelin, Edward H.] Univ Calif San Francisco, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA 94143 USA. [Murphy, Louise B.; Helmick, Charles G.] Ctr Dis Control & Prevent, Arthrit Program, Arthrit Epilepsy & Qual Life Branch, Atlanta, GA USA. [Foreman, Aimee J.; Pasta, David J.] Icon Clin Res, San Francisco, CA USA. RP Cisternas, MG (reprint author), MGC Data Serv, 5051 Millay Court, Carlsbad, CA 92008 USA. EM miriam@mgcdata.com OI Pasta, David/0000-0003-2637-9293 NR 19 TC 17 Z9 17 U1 1 U2 5 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD NOV PY 2009 VL 36 IS 11 BP 2531 EP 2538 DI 10.3899/jrheum.081068 PG 8 WC Rheumatology SC Rheumatology GA 517DP UT WOS:000271593700025 PM 19797505 ER PT J AU Gooch, BF Griffin, SO Gray, SK Kohn, WG Rozier, RG Siegal, M Fontana, M Brunson, D Carter, N Curtis, DK Donly, KJ Haering, H Hill, LF Hinson, HP Kumar, J Lampiris, L Mallatt, M Meyer, DM Miller, WR Sanzi-Schaedel, SM Simonsen, R Truman, BI Zero, DT AF Gooch, Barbara F. Griffin, Susan O. Gray, Shellie Kolavic Kohn, William G. Rozier, R. Gary Siegal, Mark Fontana, Margherita Brunson, Diane Carter, Nancy Curtis, David K. Donly, Kevin J. Haering, Harold Hill, Lawrence F. Hinson, H. Pitts Kumar, Jayanth Lampiris, Lewis Mallatt, Mark Meyer, Daniel M. Miller, Wanda R. Sanzi-Schaedel, Susan M. Simonsen, Richard Truman, Benedict I. Zero, Domenick T. TI Preventing dental caries through school-based sealant programs Updated recommendations and reviews of evidence SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article DE Caries; evidence-based dentistry; pit-and-fissure sealants; preventive dentistry; public health/community dentistry ID ASSESSMENT SYSTEM ICDAS; FISSURE SEALANTS; OCCLUSAL SURFACES; RETENTION; PIT; LESIONS; RESIN; PROPHYLAXIS; PERFORMANCE; PLACEMENT AB Background. School-based sealant programs (SBSPs) increase sealant use and reduce caries. Programs target schools that serve children from low-income families and focus on sealing newly erupted permanent molars. In 2004 and 2005, the Centers for Disease Control and Prevention (CDC), Atlanta, sponsored meetings of an expert Work group to update recommendations for sealant use in SBSPs on the basis of available evidence regarding the effectiveness of sealants on sound and carious pit and fissure surfaces, caries assessment and selected sealant placement techniques, and the risk of caries' developing in sealed teeth among children who might be lost to follow-up. The work group also identified topics for which additional evidence review was needed. Types of Studies Reviewed. The work group used systematic reviews when. available. Since 2005, staff members at CDC and subject-matter experts conducted several independent analyses of topics for which no reviews existed. These reviews include a systematic review of the effectiveness of sealants in managing caries. Results. Me evidence supports recommendations to seal sound surfaces and noncavitated lesions, to use visual assessment to detect surface cavitation, to use a toothbrush or handpiece prophylaxis to clean tooth surfaces, and to provide sealants to children even if follow-up cannot be ensured. Clinical implications. These recommendations are consistent with the current state of the science and provide appropriate guidance for sealant use in SBSPs. This report also may increase practitioners' awareness of the SBSP as an important and effective public health approach that complements clinical care. C1 [Gooch, Barbara F.; Griffin, Susan O.] Ctr Dis Control & Prevent, Div Oral Hlth Surveillance, Atlanta, GA 30341 USA. [Gray, Shellie Kolavic] Northrop Grumman, Publ Hlth Div, Atlanta, GA USA. [Rozier, R. Gary] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Hlth Policy & Management, Chapel Hill, NC USA. [Siegal, Mark] Ohio Dept Hlth, Bur Oral Hlth Serv, Columbus, OH 43266 USA. [Fontana, Margherita] Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA. [Carter, Nancy] Cincinnati Hlth Dept, Div Oral Hlth, Cincinnati, OH USA. [Brunson, Diane] Univ Colorado Denver, Sch Dent Med, Aurora, CO USA. [Donly, Kevin J.] Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, San Antonio, TX USA. [Curtis, David K.; Donly, Kevin J.; Hinson, H. Pitts] Amer Acad Pediat Dent, Chicago, IL USA. [Hill, Lawrence F.] CincySmiles Fdn, Cincinnati, OH USA. [Kumar, Jayanth] New York State Dept Hlth, Bur Dent Hlth, Albany, NY USA. [Lampiris, Lewis; Meyer, Daniel M.] Amer Dent Assoc, Chicago, IL USA. [Mallatt, Mark] Assoc State & Territorial Dent Directors, Sparks, NV USA. [Miller, Wanda R.] Natl Assoc Sch Nurses, Silver Spring, MD USA. [Sanzi-Schaedel, Susan M.] Amer Assoc Publ Hlth Dent, Springfield, IL USA. Midwestern Univ, Coll Dent Med, Glendale, AZ USA. [Truman, Benedict I.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA 30341 USA. [Zero, Domenick T.] Indiana Univ, Sch Dent, Oral Hlth Res Inst, Indianapolis, IN USA. RP Gooch, BF (reprint author), Ctr Dis Control & Prevent, Div Oral Hlth Surveillance, 4770 Buford Highway,NE,MS-F10, Atlanta, GA 30341 USA. EM oralhealth@cdc.gov OI Fontana, Margherita/0000-0003-2357-7534 NR 66 TC 52 Z9 63 U1 1 U2 5 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD NOV PY 2009 VL 140 IS 11 BP 1356 EP 1365 PG 10 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 518VY UT WOS:000271724800010 PM 19884392 ER PT J AU Bardenheier, BH Wortley, PM Shefer, A AF Bardenheier, Barbara H. Wortley, Pascale M. Shefer, Abigail TI Influenza Vaccine in African-American and White Nursing Home Residents: Is There a Gap? SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Letter ID IMMUNIZATION C1 [Bardenheier, Barbara H.; Wortley, Pascale M.; Shefer, Abigail] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, Atlanta, GA 30333 USA. RP Bardenheier, BH (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, Atlanta, GA 30333 USA. NR 5 TC 5 Z9 5 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD NOV PY 2009 VL 57 IS 11 BP 2164 EP 2165 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 512KU UT WOS:000271248500036 PM 20121969 ER PT J AU Schatzberg, SJ Li, Q Porter, BF Barber, RM Claiborne, MK Levine, JM Levine, GJ Israel, SK Young, BD Kiupel, M Greene, C Ruone, S Anderson, L Tong, SX AF Schatzberg, Scott J. Li, Qiang Porter, Brian F. Barber, Renee M. Claiborne, Mary Kate Levine, Jonathan M. Levine, Gwendolyn J. Israel, Sarah K. Young, Benjamin D. Kiupel, Matti Greene, Craig Ruone, Susan Anderson, Larry Tong, Suxiang TI Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology SO JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION LA English DT Article DE Canine distemper virus; consensus; degenerate primer; meningoencephalitis; reverse transcription polymerase chain reaction ID RT-PCR; ANTEMORTEM DIAGNOSIS; DOGS; INFECTION; IDENTIFICATION; ENCEPHALITIS; RETROVIRUS; OUTBREAK AB Despite the immunologic protection associated with routine vaccination protocols, Canine distemper virus (CDV) remains an important pathogen of dogs. Antemortem diagnosis of systemic CDV infection may be made by reverse transcription polymerase chain reaction (RT-PCR) and/or immunohistochemical testing for CDV antigen; central nervous system infection often requires postmortem confirmation via histopathology and immunohistochemistry. An 8-month-old intact male French Bulldog previously vaccinated for CDV presented with multifocal neurologic signs. Based on clinical and postmortem findings, the dog's disease was categorized as a meningoencephalitis of unknown etiology. Broadly reactive, pan-paramyxovirus RT-PCR using consensus-degenerate hybrid oligonucleotide primers, combined with sequence analysis, identified CDV amplicons in the dog's brain. Immunohistochemistry confirmed the presence of CDV antigens, and a specific CDV RT-PCR based on the phosphoprotein gene identified a wild-type versus vaccinal virus strain. This case illustrates the utility of broadly reactive PCR and sequence analysis for the identification of pathogens in diseases with unknown etiology. C1 [Schatzberg, Scott J.; Li, Qiang; Barber, Renee M.; Claiborne, Mary Kate; Greene, Craig] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA 30602 USA. [Porter, Brian F.; Levine, Gwendolyn J.] Texas A&M Univ, Dept Vet Pathobiol, Coll Vet Med & Biomed Sci, College Stn, TX USA. [Levine, Jonathan M.; Israel, Sarah K.] Texas A&M Univ, Dept Small Anim Clin Sci, Coll Vet Med & Biomed Sci, College Stn, TX USA. [Young, Benjamin D.] Texas A&M Univ, Dept Large Anim Clin Sci, Coll Vet Med & Biomed Sci, College Stn, TX USA. [Kiupel, Matti] Michigan State Univ, Dept Pathobiol & Diagnost Invest, Coll Vet Med, Lansing, MI USA. [Ruone, Susan; Anderson, Larry; Tong, Suxiang] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Schatzberg, SJ (reprint author), Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, 501 DW Brooks Dr, Athens, GA 30602 USA. EM schatz13@uga.edu FU Intramural CDC HHS [CC999999] NR 22 TC 6 Z9 6 U1 0 U2 2 PU AMER ASSOC VETERINARY LABORATORY DIAGNOSTICIANS INC PI TURLOCK PA PO BOX 1522, TURLOCK, CA 95381 USA SN 1040-6387 J9 J VET DIAGN INVEST JI J. Vet. Diagn. Invest. PD NOV PY 2009 VL 21 IS 6 BP 844 EP 849 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 519SU UT WOS:000271789100013 PM 19901287 ER PT J AU Rodriguez, A Perez-Gonzalez, A Hossain, MJ Chen, LM Rolling, T Perez-Brena, P Donis, R Kochs, G Nieto, A AF Rodriguez, Ariel Perez-Gonzalez, Alicia Hossain, M. Jaber Chen, Li-Mei Rolling, Thierry Perez-Brena, Pilar Donis, Ruben Kochs, Georg Nieto, Amelia TI Attenuated Strains of Influenza A Viruses Do Not Induce Degradation of RNA Polymerase II SO JOURNAL OF VIROLOGY LA English DT Article ID CARBOXYL-TERMINAL DOMAIN; HERPES-SIMPLEX-VIRUS; PROTEIN-SYNTHESIS SHUTOFF; CELLULAR MESSENGER-RNA; PA SUBUNIT; IN-VITRO; HUMAN INFECTION; HIGH VIRULENCE; TRANSCRIPTION; PHOSPHORYLATION AB We have previously shown that infection with laboratory-passaged strains of influenza virus causes both specific degradation of the largest subunit of the RNA polymerase II complex (RNAP II) and inhibition of host cell transcription. When infection with natural human and avian isolates belonging to different antigenic subtypes was examined, we observed that all of these viruses efficiently induce the proteolytic process. To evaluate whether this process is a general feature of nonattenuated viruses, we studied the behavior of the influenza virus strains A/PR8/8/34 (PR8) and the cold-adapted A/Ann Arbor/6/60 (AA), which are currently used as the donor strains for vaccine seeds due to their attenuated phenotype. We have observed that upon infection with these strains, degradation of the RNAP II does not occur. Moreover, by runoff experiments we observe that PR8 has a reduced ability to inhibit cellular mRNA transcription. In addition, a hypervirulent PR8 (hvPR8) variant that multiplies much faster than standard PR8 (lvPR8) in infected cells and is more virulent in mice than the parental PR8 virus, efficiently induces RNAP II degradation. Studies with reassortant viruses containing defined genome segments of both hvPR8 and lvPR8 indicate that PA and PB2 subunits individually contribute to the ability of influenza virus to degrade the RNAP II. In addition, recently it has been reported that the inclusion of PA or PB2 from hvPR8 in lvPR8 recombinant viruses, highly increases their pathogenicity. Together, the data indicate that the capacity of the influenza virus to degrade RNAP II and inhibit the host cell transcription machinery is a feature of influenza A viruses that might contribute to their virulence. C1 [Rodriguez, Ariel; Perez-Gonzalez, Alicia; Nieto, Amelia] CSIC, Ctr Nacl Biotecnol, Madrid 28049, Spain. [Rodriguez, Ariel; Perez-Gonzalez, Alicia; Nieto, Amelia] Ciber Enfermedades Resp, Mallorca, Illes Balears, Spain. [Hossain, M. Jaber; Chen, Li-Mei; Donis, Ruben] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Rolling, Thierry; Kochs, Georg] Univ Freiburg, Dept Virol, D-79107 Freiburg, Germany. [Perez-Brena, Pilar] Inst Salud Carlos III, Natl Ctr Microbiol, Influenza & Resp Viruses Lab, Majadahonda, Spain. RP Nieto, A (reprint author), CSIC, Ctr Nacl Biotecnol, Darwin 3, Madrid 28049, Spain. EM anieto@cnb.csic.es RI Rodriguez, Ariel/B-3908-2013 OI Rodriguez, Ariel/0000-0001-6850-5003 FU Ministerio de Educacion y Ciencia, Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica [BFU2005-02834]; Comunidad de Madrid [S-SAL-01852006]; Ciber de Enfermedades Respiratorias FX This study was supported by Ministerio de Educacion y Ciencia, Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (BFU2005-02834), Comunidad de Madrid (S-SAL-01852006), and Ciber de Enfermedades Respiratorias. A. R. and A. P.-G. were supported by Ciber de Enfermedades Respiratorias. NR 75 TC 22 Z9 23 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2009 VL 83 IS 21 BP 11166 EP 11174 DI 10.1128/JVI.01439-09 PG 9 WC Virology SC Virology GA 504FW UT WOS:000270602300029 PM 19692472 ER PT J AU Friedman, SD Genthner, FJ Gentry, J Sobsey, MD Vinje, J AF Friedman, Stephanie D. Genthner, Fred J. Gentry, Jennifer Sobsey, Mark D. Vinje, Jan TI Gene Mapping and Phylogenetic Analysis of the Complete Genome from 30 Single-Stranded RNA Male-Specific Coliphages (Family Leviviridae) SO JOURNAL OF VIROLOGY LA English DT Article ID REVERSE TRANSCRIPTION-PCR; ESCHERICHIA-COLI K-12; TRANSLATION TERMINATION; NUCLEOTIDE-SEQUENCE; PSEUDOMONAS-AERUGINOSA; WATER SAMPLES; STOP CODON; HOST-RANGE; PHAGE; BACTERIOPHAGE AB Male-specific single-stranded RNA (FRNA) coliphages belong to the family Leviviridae. They are classified into two genera (Levivirus and Allolevivirus), which can be subdivided into four genogroups (genogroups I and II in Levivirus and genogroups III and IV in Allolevivirus). Relatively few strains have been completely characterized, and hence, a detailed knowledge of this virus family is lacking. In this study, we sequenced and characterized the complete genomes of 19 FRNA strains (10 Levivirus strains and 9 Allolevivirus strains) and compared them to the 11 complete genome sequences available in GenBank. Nucleotide similarities among strains of Levivirus genogroups I and II were 75% to 99% and 83 to 94%, respectively, whereas similarities among strains of Allolevivirus genogroups III and IV ranged from 70 to 96% and 75 to 95%, respectively. Although genogroup I strain fr and genogroup III strains MX1 and M11 share only 70 to 78% sequence identity with strains in their respective genogroups, phylogenetic analyses of the complete genome and the individual genes suggest that strain fr should be grouped in Levivirus genogroup I and that the MX1 and M11 strains belong in Allolevivirus genogroup III. Strains within each genus share >50% sequence identity, whereas between the two genera, strains have <40% nucleotide sequence identity. Overall, amino acid composition, nucleotide similarities, and replicase catalytic domain location contributed to phylogenetic assignments. A conserved eight-nucleotide signature at the 3' end of the genome distinguishes leviviruses (5' ACCACCCA 3') from alloleviviruses (5' TCCTCCCA 3'). C1 [Friedman, Stephanie D.; Genthner, Fred J.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Friedman, Stephanie D.; Gentry, Jennifer; Sobsey, Mark D.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Vinje, Jan] Ctr Dis Control & Prevent, Natl Calicivirus Lab, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, Atlanta, GA 30333 USA. RP Friedman, SD (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM friedman.stephanie@epa.gov OI Vinje, Jan/0000-0002-1530-3675 FU Environmental Protection Agency's (EPA's) New England Regional Applied Research Effort; U.S. EPA New England Regional Laboratory FX This research was funded, in part, through the Environmental Protection Agency's (EPA's) New England Regional Applied Research Effort. We gratefully acknowledge the assistance of Jack Paar III, U.S. EPA New England Regional Laboratory, for initiating and sponsoring this program. NR 44 TC 13 Z9 13 U1 0 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2009 VL 83 IS 21 BP 11233 EP 11243 DI 10.1128/JVI.01308-09 PG 11 WC Virology SC Virology GA 504FW UT WOS:000270602300036 PM 19710143 ER PT J AU Goldberg, TL Sintasath, DM Chapman, CA Cameron, KM Karesh, WB Tang, S Wolfe, ND Rwego, IB Ting, N Switzer, WM AF Goldberg, Tony L. Sintasath, David M. Chapman, Colin A. Cameron, Kenneth M. Karesh, William B. Tang, Shaohua Wolfe, Nathan D. Rwego, Innocent B. Ting, Nelson Switzer, William M. TI Coinfection of Ugandan Red Colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with Novel, Divergent Delta-, Lenti-, and Spumaretroviruses SO JOURNAL OF VIROLOGY LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; KIBALE-NATIONAL-PARK; CROSS-SPECIES TRANSMISSION; AFRICAN-GREEN MONKEYS; MOLECULAR CHARACTERIZATION; NONHUMAN-PRIMATES; FOAMY VIRUS; PHYLOGENETIC ANALYSIS; MANDRILLUS-SPHINX; COTE-DIVOIRE AB Nonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins of human immunodeficiency viruses type 1 (HIV-1) and HIV-2. However, incomplete taxonomic and geographic sampling of potential hosts, especially the African colobines, has left the full range of primate retrovirus diversity unexplored. Blood samples collected from 31 wild-living red colobus monkeys (Procolobus [Piliocolobus] rufomitratus tephrosceles) from Kibale National Park, Uganda, were tested for antibodies to simian immunodeficiency virus (SIV), simian T-cell lymphotrophic virus (STLV), and simian foamy virus (SFV) and for nucleic acids of these same viruses using genus-specific PCRs. Of 31 red colobus tested, 22.6% were seroreactive to SIV, 6.4% were seroreactive to STLV, and 97% were seroreactive to SFV. Phylogenetic analyses of SIV polymerase (pol), STLV tax and long terminal repeat (LTR), and SFV pol and LTR sequences revealed unique SIV and SFV strains and a novel STLV lineage, each divergent from corresponding retroviral lineages previously described in Western red colobus (Procolobus badius badius) or black-and-white colobus (Colobus guereza). Phylogenetic analyses of host mitochondrial DNA sequences revealed that red colobus populations in East and West Africa diverged from one another approximately 4.25 million years ago. These results indicate that geographic subdivisions within the red colobus taxonomic complex exert a strong influence on retroviral phylogeny and that studying retroviral diversity in closely related primate taxa should be particularly informative for understanding host-virus coevolution. C1 [Goldberg, Tony L.] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. [Sintasath, David M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. [Chapman, Colin A.] McGill Univ, Dept Anthropol, Montreal, PQ H3A 2T7, Canada. [Chapman, Colin A.] McGill Univ, McGill Sch Environm, Montreal, PQ H3A 2T7, Canada. [Chapman, Colin A.; Cameron, Kenneth M.; Karesh, William B.] Wildlife Conservat Soc, Bronx, NY 10460 USA. [Tang, Shaohua; Switzer, William M.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Wolfe, Nathan D.] Global Viral Forecasting Initiat, San Francisco, CA 94104 USA. [Wolfe, Nathan D.] Stanford Univ, Program Human Biol, Stanford, CA 94305 USA. [Goldberg, Tony L.; Chapman, Colin A.; Rwego, Innocent B.] Makerere Univ, Dept Zool, Kampala, Uganda. [Ting, Nelson] Univ Iowa, Dept Anthropol, Iowa City, IA 52242 USA. [Ting, Nelson] Univ Iowa, Roy J Carver Ctr Comparat Genom, Iowa City, IA 52242 USA. RP Goldberg, TL (reprint author), Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, 2015 Linden Dr, Madison, WI 53706 USA. EM tgoldberg@vetmed.wisc.edu RI Rwego, Innocent/I-5049-2013 OI Rwego, Innocent/0000-0003-1274-7788 FU NSERC; CFI; WCS; CRC; NSF Graduate Research Fellowship; Global Viral Forecasting Initiative; Morris Animal Foundation FX Support for this study was provided in part by NSERC, CFI, WCS, and CRC funding (to C. A. C.); an NSF Graduate Research Fellowship (to D. M. S.); NSF and PCI funding (to N.T.); the Global Viral Forecasting Initiative and a NIH Director's Pioneer Award (to N.D.W.); and the Morris Animal Foundation through its support of the Kibale EcoHealth Project (to T. L. G.). NR 70 TC 40 Z9 40 U1 0 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2009 VL 83 IS 21 BP 11318 EP 11329 DI 10.1128/JVI.02616-08 PG 12 WC Virology SC Virology GA 504FW UT WOS:000270602300044 PM 19692478 ER PT J AU Watson, M Saraiya, M Wu, XC AF Watson, Meg Saraiya, Mona Wu, Xiaocheng TI Update of HPV-Associated Female Genital Cancers in the United States, 1999-2004 SO JOURNAL OF WOMENS HEALTH LA English DT Editorial Material ID HUMAN-PAPILLOMAVIRUS; VULVAR; IMPACT; RATES AB In 2008, CDC published a supplement to the journal Cancer describing incidence patterns of human papillomavirus (HPV)-associated cancers prior to availability of an HPV vaccine. This report updates the information on HPV-associated female genital cancer incidence with more recent data, adds information on trends, and includes American Indian/Alaska Native (AI/AN) populations. We used combined data from two federal cancer surveillance programs, CDC's National Program of Cancer Registries (NPCR) and NCI's Surveillance, Epidemiology, and End Results (SEER) Program, covering 92% of the U. S. population from 1999 to 2004, to examine recent trends and incidence of invasive cervical carcinoma and vaginal and vulvar squamous cell carcinoma (SCC). Incidence of in situ vaginal and vulvar SCC are also presented. The average annual age-adjusted rate of cervical cancer among women of all races/ethnicities was 8.5/100,000. Annual cervical cancer incidence rates were highest but declined more rapidly among Hispanic and black women compared with non-Hispanic and white women. The rate of vulvar cancer among all women was 1.7/100,000 and was higher among white women than other racial groups. Vulvar cancer rates rose among black women (+2.9% per year) and were relatively stable among all other racial and ethnic groups over the 6-year period. Vaginal cancer was rare (rate 0.5/100,000); the rate was higher among black women than other racial groups and higher among Hispanic women than among non-Hispanic women. A significant decline of vaginal cancer was observed only among black women (-6.2% per year). This article confirms previous findings on racial disparities in HPV-associated female genital cancers. Any post-HPV vaccine declines in these cancers should be interpreted in light of current declines. Enhancing current cancer surveillance systems, combined with special studies to collect data on in situ or precancerous lesions of these cancers, will provide important information in determining the potential impact of the HPV vaccine. C1 [Watson, Meg] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Wu, Xiaocheng] Louisiana Tumor Registry, New Orleans, LA USA. RP Watson, M (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, 4770 Buford Highway,MS K-55, Atlanta, GA 30341 USA. EM eze5@cdc.gov NR 20 TC 24 Z9 25 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD NOV PY 2009 VL 18 IS 11 BP 1731 EP 1738 DI 10.1089/jwh.2009.1570 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 525XH UT WOS:000272250500001 PM 19951205 ER PT J AU Ahluwalia, IB Tessaro, I Rye, S Parker, L AF Ahluwalia, Indu B. Tessaro, Irene Rye, Sheila Parker, Lindsey TI Self-Reported and Clinical Measurement of Three Chronic Disease Risks among Low-Income Women in West Virginia SO JOURNAL OF WOMENS HEALTH LA English DT Article ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; BLOOD-PRESSURE; VALIDITY; HYPERTENSION; CHOLESTEROL; AWARENESS; ACCURACY; WEIGHT; HEIGHT AB Background: This study assessed the validity of several self-reported cardiovascular risk factors among low-income women aged 40-64 years in West Virginia. Methods: A cross-sectional survey was conducted of 733 women participating in the Well Integrated Screening and Evaluation for Women Across the Nation (WISEWOMAN) project in West Virginia to examine agreement between self-report and clinical screenings in the prevalence of risk factors related to coronary heart disease (CHD). Women participating in the study were interviewed face-to-face before administration of clinical screenings that assessed height, weight, Quetelet's index, high blood pressure (systolic >= 140mm Hg or diastolic >= 90mm Hg), and elevated total cholesterol concentrations (>= 200 mg/dL and >= 240 mg/dL). Results: The overall results showed high sensitivity and specificity for each of the risk factors examined; for overweight/obesity, the sensitivity was 96% and specificity was 93%; for cholesterol >= 240 mg/dL, sensitivity was 85% and specificity was 67%; for hypertension, sensitivity was 77% and specificity was 86%. Using a threshold value of >= 240mg/dL for hypercholesterolemia led to higher sensitivity but a lower specificity than for a value of >= 200 mg/dL. Conclusions: This study found that among low-income women at higher risk for cardiovascular disease (CVD), self-reported values for high body mass index (BMI), hypercholesterolemia, and hypertension were well correlated with clinical measures, as indicated by high sensitivity values. Thus, self-reported values can be used for surveillance, targeted screenings, and health promotion activities, including lifestyle changes. C1 [Ahluwalia, Indu B.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Tessaro, Irene; Rye, Sheila; Parker, Lindsey] W Virginia Univ, Sch Nursing, Morgantown, WV 26506 USA. RP Ahluwalia, IB (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-66, Atlanta, GA 30341 USA. EM Iahluwalia@cdc.gov NR 21 TC 9 Z9 10 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD NOV PY 2009 VL 18 IS 11 BP 1857 EP 1862 DI 10.1089/jwh.2009.1360 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 525XH UT WOS:000272250500018 PM 19951222 ER PT J AU Blackwell, DL Martinez, ME Gentleman, JF Sanmartin, C Berthelot, JM AF Blackwell, Debra L. Martinez, Michael E. Gentleman, Jane F. Sanmartin, Claudia Berthelot, Jean-Marie TI Socioeconomic Status and Utilization of Health Care Services in Canada and the United States Findings From a Binational Health Survey SO MEDICAL CARE LA English DT Article DE hospitalizations; doctor contacts or visits; Canada; United States; insurance; socioeconomic status ID MEDICAL-CARE; ETHNIC-DIFFERENCES; PHYSICIANS SERVICES; BEHAVIORAL-MODEL; POLICY SURVEY; ACCESS; DISPARITIES; INSURANCE; INEQUALITIES; COVERAGE AB Objectives: Building on Andersen's behavioral model for the utilization of health care services, we examined factors associated with utilization of physician and hospital services among adults in Canada and the United States, with a focus on socioeconomic status (enabling resources in Andersen's framework). Methods: Using the 2002-2003 Joint Canada/United States Survey of Health, we conducted country-specific multivariate logistic regressions predicting doctor contacts/visits and overnight hospitalizations in the past year, controlling for predisposing characteristics, enabling resources, and several factors representing perceived need for health care. All analyses were appropriately weighted to yield nationally representative results. Results: Several measures of socioeconomic status-having a regular medical doctor, education, and, in the US income and insurance coverage-were associated with doctor contacts or visits in both countries, along with various predisposing and need factors. However, these same measures were not associated with hospitalizations in either country. Instead, only the individual's predisposing characteristics (eg, age and sex) and his/her need for health care predicted utilization of hospital services in Canada and the United States. Insurance coverage status in the United States became a significant predictor of hospitalizations when count data were analyzed via Poisson regression. Conclusions: Given our particular outcome measures, adults in Canada and the United States exhibited similar patterns of hospital utilization, and socioeconomic status played no explanatory role. However, relative to Canadian adults, we found disparities in doctor contacts among US adults-between those with more income and those with less, between those with health insurance and those without-after adjusting for health care needs and predisposing characteristics. C1 [Blackwell, Debra L.; Martinez, Michael E.; Gentleman, Jane F.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Sanmartin, Claudia] STAT Canada, Hlth Anal & Measurement Grp, Ottawa, ON, Canada. [Berthelot, Jean-Marie] Canadian Inst Hlth Informat, Ottawa, ON, Canada. RP Blackwell, DL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 2326, Hyattsville, MD 20782 USA. EM dblackwell@cdc.gov FU Canada/United States Survey of Health; National Center for Health Statistics; Canadian Institutes of Health Research; Robert Wood Johnson Foundation FX Funding for the Joint Canada/United States Survey of Health was provided by Statistics Canada, the National Center for Health Statistics, the Canadian Institutes of Health Research, and the Robert Wood Johnson Foundation. NR 57 TC 40 Z9 41 U1 1 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD NOV PY 2009 VL 47 IS 11 BP 1136 EP 1146 PG 11 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 515DM UT WOS:000271447000005 PM 19786920 ER PT J AU Inoue, K Kabeya, H Kosoy, MY Bai, Y Smirnov, G McColl, D Artsob, H Maruyama, S AF Inoue, Kai Kabeya, Hidenori Kosoy, Michael Y. Bai, Ying Smirnov, George McColl, Dorothy Artsob, Harvey Maruyama, Soichi TI Evolutional and Geographical Relationships of Bartonella grahamii Isolates from Wild Rodents by Multi-locus Sequencing Analysis (vol 57, pg 534, 2009) SO MICROBIAL ECOLOGY LA English DT Correction C1 [Inoue, Kai; Kabeya, Hidenori; Maruyama, Soichi] Nihon Univ, Lab Vet Publ Hlth, Dept Vet Med, Coll Bioresource Sci, Kanagawa 2528510, Japan. [Kosoy, Michael Y.; Bai, Ying] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Infect Dis, Ft Collins, CO USA. [Smirnov, George] Russian Acad Med Sci, NF Gamaleya Epidemiol & Microbiol Res Inst, Moscow, Russia. [McColl, Dorothy; Artsob, Harvey] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. RP Maruyama, S (reprint author), Nihon Univ, Lab Vet Publ Hlth, Dept Vet Med, Coll Bioresource Sci, 1866 Kameino, Kanagawa 2528510, Japan. EM maruyama.soichi@nihon-u.ac.jp NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0095-3628 J9 MICROB ECOL JI Microb. Ecol. PD NOV PY 2009 VL 58 IS 4 BP 966 EP 967 DI 10.1007/s00248-009-9579-8 PG 2 WC Ecology; Marine & Freshwater Biology; Microbiology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Microbiology GA 515HS UT WOS:000271461000025 ER PT J AU Robinson, JB Telepnev, MV Zudina, IV Bouyer, D Montenieri, JA Bearden, SW Gage, KL Agar, SL Foltz, SM Chauhan, S Chopra, AK Motin, VL AF Robinson, Jennilee B. Telepnev, Maxim V. Zudina, Irina V. Bouyer, Donald Montenieri, John A. Bearden, Scott W. Gage, Kenneth L. Agar, Stacy L. Foltz, Sheri M. Chauhan, Sadhana Chopra, Ashok K. Motin, Vladimir L. TI Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models SO MICROBIAL PATHOGENESIS LA English DT Article DE Yersinia pestis; Type VI secretion system; Plague; Macrophage; Murine model; Xenopsylla cheopis ID MOUSE PERITONEAL-MACROPHAGES; LOW-CALCIUM RESPONSE; PATHOGENICITY ISLAND; PROTEIN SECRETION; AGROBACTERIUM-TUMEFACIENS; PSEUDOMONAS-AERUGINOSA; VIRULENCE DETERMINANTS; EDWARDSIELLA-TARDA; ESCHERICHIA-COLI; PNEUMONIC PLAGUE AB Type VI secretion systems (T6SSs) have been identified recently in several Gram-negative organisms and have been shown to be associated with virulence in some bacterial pathogens. A T6SS of Yersinia pestis CO92 (locus YPO0499-YPO0516) was deleted followed by investigation of the phenotype of this mutation. We observed that this T6SS locus of Y. pesos was preferentially expressed at 26 degrees C in comparison to 37 degrees C suggesting a possible role in the flea cycle. However, we found that the deletion of T6SS locus YPO0499-YPO0516 in Y pestis CO92 had no effect on the ability of this strain to infect the oriental rat flea, Xenopsylla cheopis. Nevertheless, this mutant displayed increased intracellular numbers in macrophage-like J774.A1 cells after 20 h post-infection for bacterial cells pre-grown at 26 degrees C indicating that expression of this T6SS locus limited intracellular replication in macrophages. In addition, deletion of the YPO0499-YPO0516 locus reduced the uptake by macrophages of the Y. pestis mutant pre-grown at 37 degrees C, suggesting that this T6SS locus has phagocytosis-promoting activity. Further study of the virulence of the T6SS mutant in murine bubonic and inhalation plague models revealed no attenuation in comparison with the parental CO92 strain. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Robinson, Jennilee B.; Telepnev, Maxim V.; Zudina, Irina V.; Agar, Stacy L.; Foltz, Sheri M.; Chauhan, Sadhana; Chopra, Ashok K.; Motin, Vladimir L.] Univ Texas Med Branch, Dept Pathol, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Bouyer, Donald; Motin, Vladimir L.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Montenieri, John A.; Bearden, Scott W.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Infect Dis, Natl Ctr Zoonot Enter & Vector Borne Dis, Ft Collins, CO 80522 USA. RP Motin, VL (reprint author), Univ Texas Med Branch, Dept Pathol, Dept Microbiol & Immunol, 301 Univ Blvd, Galveston, TX 77555 USA. EM vlmotin@utmb.edu RI Motin, Vladimir/O-1535-2013 FU Sealy Center for Vaccine Development of the University of Texas Medical Branch; NIH/NIAID [U54 AI057156, R01 AI064389]; NIH [AI060549, AI07526] FX This study was supported by the Sealy Center for Vaccine Development of the University of Texas Medical Branch, NIH/NIAID Western RCE grant U54 AI057156, and NIH/NIAID grant R01 AI064389. JBR was supported by the NIH T32 Biodefense Training grant AI060549. Likewise, SLA was supported in part by the T32 NIH training grant on Tropical and Emerging Infectious Diseases (AI07526) and Biodefense (AI060549). We thank Dr. A. Torres for thoughtful discussion and Dr. R. Pieper for sharing his manuscript on Y. pesos proteomic analysis prior to publication. We thank Eric Mandel for his help with statistical analysis. NR 52 TC 25 Z9 25 U1 0 U2 6 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD NOV PY 2009 VL 47 IS 5 BP 243 EP 251 DI 10.1016/j.micpath.2009.08.005 PG 9 WC Immunology; Microbiology SC Immunology; Microbiology GA 518MD UT WOS:000271695800001 PM 19716410 ER PT J AU Ramachandran, S Williamson, D Hall, L AF Ramachandran, Shruti Williamson, Dhelia Hall, Laura TI Case-control study of environmental exposures in individuals with multiple sclerosis in three geographic areas SO MULTIPLE SCLEROSIS LA English DT Meeting Abstract CT 14th Annual Meeting of the Americas-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/Cons ortium-for-Multiple-Sclerosis-Centers CY MAY 27-30, 2009 CL Atlanta, GA SP Amer Comm Treatment & Res Multiple Sclerosis, Consortium Multiple Sclerosis Ctr C1 [Ramachandran, Shruti; Williamson, Dhelia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hall, Laura] Applicat Int Corp, Dept Sci, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1352-4585 J9 MULT SCLER JI Mult. Scler. PD NOV PY 2009 VL 15 IS 11 BP 1402 EP 1402 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 516IU UT WOS:000271536400058 ER PT J AU Benkovic, SA O'Callaghan, JP Miller, DB AF Benkovic, Stanley A. O'Callaghan, James P. Miller, Diane B. TI Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice SO NEUROTOXICOLOGY LA English DT Article DE Blood-brain barrier; Excitotoxicity; Glia; Neurodegeneration; Neuroprotection; Stress ID BLOOD-BRAIN-BARRIER; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MICROGLIAL ACTIVATION; ALZHEIMERS-DISEASE; POSTNATAL RATS; AMEBOID MICROGLIA; MESSENGER-RNA; DEXAMETHASONE; STRESS; GLUCOCORTICOIDS AB High levels of stress or stress hormones have been reported to exacerbate a variety of human disorders of the cardiovascular, gastrointestinal, immune, reproductive, and nervous systems. In rats, high glucocorticoid levels have been reported to cause neuronal death and injury as well as enhance susceptibility to neurotoxic agents and attenuate repair mechanisms: however, the impact of high dosages of CORT in mice has not been fully evaluated. We investigated the ability of supraphysiological levels of CORT to cause hippocampal neuronal death, and to modulate the neurotoxicity of kainic acid (KA) in male C57BL/6J mice. Timed-release CORT pellets (10, 35, 100 mg/21 d) were implanted subcutaneously in the back of mice, and the sustained release of glucocorticoid caused involution of the thymus and decreased the weight of the spleen. Kainic acid caused stage 1 seizures that were unaffected by CORT; however, steroid treatment decreased KA-associated mortality. Little neuronal damage was detected by the cupric-silver neurodegeneration stain. Neurotoxicity caused by an intraperitoneal injection of 25 mg/kg KA was attenuated by seven days of CORT pre-treatment. The KA-induced increase in cupric-silver staining, reactive gliosis, microglial activation, and blood-brain barrier disruption was attenuated indicating neuroprotection. Our data indicate supraphysiological levels of CORT do not cause neuronal death or injury in hippocampus of C57BL/6J mice and provide neuroprotection against KA-induced neural damage. Published by Elsevier Inc. C1 [Benkovic, Stanley A.; O'Callaghan, James P.; Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Miller, DB (reprint author), CDC NIOSH, HELD TMBB, Mail Stop 3014,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM zcg9@cdc.gov; dum6@cdc.gov RI O'Callaghan, James/O-2958-2013 NR 84 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD NOV PY 2009 VL 30 IS 6 BP 965 EP 976 DI 10.1016/j.neuro.2009.07.005 PG 12 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 534CS UT WOS:000272873700012 PM 19616023 ER PT J AU Yolton, K Khoury, J Xu, YY Succop, P Lanphear, B Bernert, JT Lester, B AF Yolton, Kimberly Khoury, Jane Xu, Yingying Succop, Paul Lanphear, Bruce Bernert, John T. Lester, Barry TI Low-level prenatal exposure to nicotine and infant neurobehavior SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Tobacco smoke; Prenatal exposure; Infant neurobehavior ID ENVIRONMENTAL TOBACCO-SMOKE; NUTRITION EXAMINATION SURVEY; SERUM COTININE LEVELS; MATERNAL LIFE-STYLE; 3RD NATIONAL-HEALTH; CIGARETTE-SMOKING; COCAINE EXPOSURE; BIRTH-WEIGHT; NEWBORN NEUROBEHAVIOR; SUBSTANCE EXPOSURE AB Objective: To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. Study design: Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobacco smoke exposure was measured twice during pregnancy and once at delivery using maternal serum cotinine. Infant neurobehavior was assessed with the NICU Network Neurobehavioral Scale at approximately 5 weeks after birth. Results: Prenatal tobacco smoke exposure was significantly associated with infant neurobehavior after controlling for important covariates, but the specific behaviors associated with exposure varied by race. In White infants, higher cotinine was associated with increased arousal (p=.030) and excitability (p=.034), and decreased self-regulation (p=.010). In contrast, among Black infants, higher cotinine was associated with decreased arousal (p=.001), excitability (p=.021), and special handling required to complete the assessment (p=.003), and increased self-regulation (p=.021) and hypotonicity (p=.016). In secondary analyses. we found racial differences in the effects of postnatal exposure to second hand smoke and low-level prenatal exposure. Conclusions: Low-level prenatal tobacco smoke exposure is associated with infant neurobehavior at 5 weeks of age, but the specific effects differ by race. These effects may reflect racial differences in nicotine metabolism that are similar to differences reported in adult and child studies of tobacco. (C) 2009 Elsevier Inc. All rights reserved. C1 [Yolton, Kimberly; Xu, Yingying] Cincinnati Childrens Hosp, Med Ctr, Div Gen & Community Pediat, Dept Pediat, Cincinnati, OH 45229 USA. [Khoury, Jane] Cincinnati Childrens Hosp, Med Ctr, Div Biostat & Epidemiol, Dept Pediat, Cincinnati, OH 45229 USA. [Succop, Paul] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA. [Lanphear, Bruce] Simon Fraser Univ, Fac Hlth Sci, Vancouver, BC, Canada. [Lanphear, Bruce] British Columbia Childrens Hosp, Child & Family Res Inst, Vancouver, BC V6H 3V4, Canada. [Bernert, John T.] Ctr Dis Control, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30333 USA. [Lester, Barry] Brown Univ, Women & Infants Hosp, Warren Alpert Med Sch, Ctr Study Children Risk, Providence, RI USA. RP Yolton, K (reprint author), Cincinnati Childrens Hosp, Med Ctr, Div Gen & Community Pediat, Dept Pediat, 3333 Burnet Ave,ML 7035, Cincinnati, OH 45229 USA. EM kimberly.yolton@cchmc.org RI Khoury, Jane/O-2068-2015 FU National Institute of Environmental Health Sciences [062620_CIA]; Environmental Protection Agency [PO1 ES11261] FX This work was partially supported by a grant from the Flight Attendant Medical Research Institute (062620_CIA) and from a Children's Environmental Health Center Grant from the National Institute of Environmental Health Sciences and the Environmental Protection Agency (PO1 ES11261). The study sponsors made no contributions to study design, data collection, analysis, interpretation, writing of this paper, or decisions to submit for publication. NR 58 TC 25 Z9 25 U1 3 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2009 VL 31 IS 6 BP 356 EP 363 DI 10.1016/j.ntt.2009.07.004 PG 8 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 518YL UT WOS:000271732100005 PM 19619640 ER PT J AU Krieg, EF Butler, MA Chang, MH Liu, TB Yesupriya, A Lindegren, ML Dowling, N AF Krieg, Edward F. Butler, Mary Ann Chang, Man-huei Liu, Tiebin Yesupriya, Ajay Lindegren, Mary Lou Dowling, Nicole CA CDC NCI NHANES III Genomics Workin TI Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Blood lead; Cognitive function; ALAD; Homocysteine; NHANES III ID DELTA-AMINOLEVULINIC-ACID; BLOOD LEAD; DEHYDRATASE POLYMORPHISM; 5-AMINOLEVULINIC ACID; HUMAN-ERYTHROCYTES; INORGANIC LEAD; RENAL-FUNCTION; RAT-KIDNEY; WORKERS; EXPOSURE AB The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype. Published by Elsevier Inc. C1 [Krieg, Edward F.] NIOSH, Robert A Taft Labs, Cincinnati, OH 45226 USA. [Chang, Man-huei; Liu, Tiebin; Yesupriya, Ajay; Dowling, Nicole] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30341 USA. [Lindegren, Mary Lou] Natl Ctr HIV Hepatitis STD & TB Prevent, Global AIDS Progam, Atlanta, GA 30333 USA. RP Krieg, EF (reprint author), NIOSH, Robert A Taft Labs, 4676 Columbia Pkwy,MS C-22, Cincinnati, OH 45226 USA. EM erk3@cdc.gov NR 54 TC 20 Z9 20 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2009 VL 31 IS 6 BP 364 EP 371 DI 10.1016/j.ntt.2009.08.003 PG 8 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 518YL UT WOS:000271732100006 PM 19686844 ER PT J AU Sisson, SB Katzmarzyk, PT Srinivasan, SR Chen, W Freedman, DS Bouchard, C Berenson, GS AF Sisson, Susan B. Katzmarzyk, Peter T. Srinivasan, Sathanur R. Chen, Wei Freedman, David S. Bouchard, Claude Berenson, Gerald S. TI Ethnic Differences in Subcutaneous Adiposity and Waist Girth in Children and Adolescents SO OBESITY LA English DT Article ID RACIAL-DIFFERENCES; AFRICAN-AMERICAN; BODY FATNESS; RISK-FACTORS; SKINFOLD THICKNESSES; PHYSICAL-ACTIVITY; FAT DISTRIBUTION; UNITED-STATES; CHILDHOOD BMI; YOUNG-ADULTS AB The purpose of this study was to examine ethnic differences in adiposity as measured by sum of skinfolds (SKF) and waist circumference (WC) in children and adolescents, after statistical adjustment for the BMI and age. A cross-sectional sample of 3,218 (55% white, 49% male) children and adolescents aged 5-18 years who participated in the Bogalusa Heart Study (1992-1994) were included in these analyses. Sex-specific ANOVAs, adjusted for BMI and age, for each 2-year age group compared measures of adiposity (SKF and WC) between ethnic groups. No significant differences in the proportions of children and adolescents who were overweight and obese by ethnicity or sex were found. Mean SKF in normal weight (P < 0.0001) and overweight (P < 0.0001) categories was higher for white than black children of both sexes. Across most age categories, white boys and girls had significantly higher SKF than black boys and girls, respectively (P <= 0.05). Across most age categories, white boys had significantly higher WC than black boys (P <= 0.05) with no difference in the girls, when adjusted for BMI and age. Measures of adiposity in childhood and adolescence were significantly higher in white children compared to black children, when adjusted for BMI and age. Throughout childhood and adolescence, white boys and girls had higher SKF and white boys had higher WC. Differences in adiposity between ethnic groups should be considered in disease risk assessment and stratification as they are observed even for a given BMI level. C1 [Sisson, Susan B.; Katzmarzyk, Peter T.; Bouchard, Claude] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Srinivasan, Sathanur R.; Chen, Wei; Berenson, Gerald S.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Tulane Ctr Cardiovascula Hlth, New Orleans, LA USA. [Freedman, David S.] Ctr Dis Control & Prevent, Div Nutr Phys Activ & Obes, Atlanta, GA USA. RP Katzmarzyk, PT (reprint author), Pennington Biomed Res Ctr, Baton Rouge, LA USA. RI Bouchard, Claude/A-7637-2009; OI Katzmarzyk, Peter/0000-0002-9280-6022 FU National Institute on Aging [HL38844]; National Institute of Child Health and Human Development [HD043820]; George A Bray Chair in Nutrition; Louisiana Public Facilities Authority Endowed Chair in Nutrition FX This research was supported by grant HL38844 from the National Institute on Aging and grant HD043820 from the National Institute of Child Health and Human Development. C.B. is partially supported by the George A Bray Chair in Nutrition P T.K is partially supported by the Louisiana Public Facilities Authority Endowed Chair in Nutrition. The Bogalusa Heart Study is a joint effort of many investigators and staff members, whose contributions are gratefully acknowledged NR 38 TC 9 Z9 10 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1930-7381 J9 OBESITY JI Obesity PD NOV PY 2009 VL 17 IS 11 BP 2075 EP 2081 DI 10.1038/oby.2009.132 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 512HT UT WOS:000271237700018 PM 19390519 ER PT J AU Tepper, NK Farr, SL Danner, SP Maupin, R Nesheim, SR Cohen, MH Rivero, YA Webber, MP Bulterys, M Lindsay, MK Jamieson, DJ AF Tepper, Naomi K. Farr, Sherry L. Danner, Susan P. Maupin, Robert Nesheim, Steven R. Cohen, Mardge H. Rivero, Yvette A. Webber, Mayris P. Bulterys, Marc Lindsay, Michael K. Jamieson, Denise J. TI Rapid Human Immunodeficiency Virus Testing in Obstetric Outpatient Settings: The MIRIAD Study EDITORIAL COMMENT SO OBSTETRICAL & GYNECOLOGICAL SURVEY LA English DT Editorial Material C1 [Tepper, Naomi K.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS, STD & TB Prevent, Atlanta, GA USA. Louisiana State Univ, Sch Med, Dept Obstet & Gynecol, New Orleans, LA USA. Stroger Hosp, CORE Ctr, Chicago, IL USA. Univ Miami, Sch Med, Dept Obstet & Gynecol, Miami, FL 33101 USA. Montefiore Med Ctr, Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. Ctr Dis Control & Prevent, CDC Global AIDS Program, Beijing, Peoples R China. Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA. RP Tepper, NK (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7828 J9 OBSTET GYNECOL SURV JI Obstet. Gynecol. Surv. PD NOV PY 2009 VL 64 IS 11 BP 701 EP 702 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 515QO UT WOS:000271487800002 ER PT J AU Van Dyke, MK Phares, CR Lynfield, R Thomas, AR Arnold, KE Craig, AS Mohle-Boetani, J Gershman, K Schaffner, W Petit, S Zansky, SM Morin, CA Spina, NL Wymore, K Harrison, LH Shutt, KA Bareta, J Bulens, SN Zell, ER Schuchat, A Schrag, SJ AF Van Dyke, Melissa K. Phares, Christina R. Lynfield, Ruth Thomas, Ann R. Arnold, Kathryn E. Craig, Allen S. Mohle-Boetani, Janet Gershman, Ken Schaffner, William Petit, Susan Zansky, Shelley M. Morin, Craig A. Spina, Nancy L. Wymore, Kathryn Harrison, Lee H. Shutt, Kathleen A. Bareta, Joseph Bulens, Sandra N. Zell, Elizabeth R. Schuchat, Anne Schrag, Stephanie J. TI Evaluation of Universal Antenatal Screening for Group B Streptococcus EDITORIAL COMMENT SO OBSTETRICAL & GYNECOLOGICAL SURVEY LA English DT Editorial Material C1 [Van Dyke, Melissa K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Off Workforce & Career Dev, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. Minnesota Dept Hlth, St Paul, MN USA. Oregon Publ Hlth Div, Portland, OR USA. Georgia Dept Human Resources, Div Publ Hlth, Atlanta, GA USA. Tennessee Dept Hlth, Nashville, TN USA. Calif Emerging Infect Program, Oakland, CA USA. Colorado Dept Publ Hlth & Environm, Denver, CO USA. Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. Connecticut Dept Publ Hlth, Hartford, CT USA. New York State Dept Hlth, Emerging Infect Program, Albany, NY USA. Univ Pittsburgh, Pittsburgh, PA USA. New Mexico Dept Hlth, Santa Fe, NM USA. RP Van Dyke, MK (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Off Workforce & Career Dev, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7828 J9 OBSTET GYNECOL SURV JI Obstet. Gynecol. Surv. PD NOV PY 2009 VL 64 IS 11 BP 703 EP 704 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 515QO UT WOS:000271487800003 ER PT J AU Trivers, KF Benard, VB Eheman, CR Royalty, JE Ekwueme, DU Lawson, HW AF Trivers, Katrina F. Benard, Vicki B. Eheman, Christie R. Royalty, Janet E. Ekwueme, Donatus U. Lawson, Herschel W. TI Repeat Pap Testing and Colposcopic Biopsies in the Underserved SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID EARLY-DETECTION PROGRAM; RANDOMIZED CONTROLLED-TRIAL; ATYPICAL SQUAMOUS-CELLS; NATIONAL BREAST; UNITED-STATES; CONSENSUS GUIDELINES; COST-EFFECTIVENESS; LOW-INCOME; WOMEN; MANAGEMENT AB OBJECTIVE: To quantify repeat Pap testing and colposcopic biopsies among women in the National Breast and Cervical Cancer Early Detection Program between 2003 and 2006 (N=955,494). METHODS: Rates of repeat Pap testing (two tests within 9 months) and colposcopic biopsies were estimated along with 95% confidence-intervals (CIs). Odds ratios and 95% CIs for receipt of colposcopic biopsy compared with repeat Pap testing were estimated from multivariable logistic regression models. Finally, we estimated positive predictive values and 95% CIs of cervical intraepithelial neoplasia (CIN) 2 or worse (CIN 3, carcinoma in situ, invasive cancer) for two strategies: 1) repeat Pap testing followed by colposcopic biopsy and 2) colposcopic biopsy alone. RESULTS: There were 39,583 and 53,880 women with repeat Pap testing and colposcopic biopsy, respectively, from 2003 to 2006. Overall, age-standardized rates of repeat Pap testing and colposcopic biopsies were 37.2 per 1,000 women and 39.3 per 1,000 women, respectively. Younger women, Hispanic women, and African-American women were more likely to receive colposcopic biopsies compared with repeat Pap tests. Positive predictive values of colposcopic biopsy were highest after abnormal Pap test results (27% after a result of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, 70% after a result of high-grade squamous intraepithelial lesion/squamous cell cancer). CONCLUSION: Colposcopic biopsies are common among young women after being screened for cervical cancer and, except among those with the most severe Pap test results, may not be efficient in detecting serious disease. These results conflict with current recommendations for less aggressive follow-up for most young women. (Obstet Gynecol 2009,114:1049-56) C1 [Trivers, Katrina F.; Benard, Vicki B.; Eheman, Christie R.; Royalty, Janet E.; Ekwueme, Donatus U.; Lawson, Herschel W.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Trivers, KF (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-55, Atlanta, GA 30341 USA. EM ktrivers@cdc.gov FU Centers for Disease Control and Prevention (CDC) FX Dr. Trivers was supported in part by the Research Participation Program at the Centers for Disease Control and Prevention (CDC), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 25 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 2009 VL 114 IS 5 BP 1049 EP 1056 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 513AH UT WOS:000271293500013 PM 20168106 ER PT J AU Vesco, KK Dietz, PM Rizzo, J Stevens, VJ Perrin, NA Bachman, DJ Callaghan, WM Bruce, FC Hornbrook, MC AF Vesco, Kimberly K. Dietz, Patricia M. Rizzo, Joanne Stevens, Victor J. Perrin, Nancy A. Bachman, Donald J. Callaghan, William M. Bruce, F. Carol Hornbrook, Mark C. TI Excessive Gestational Weight Gain and Postpartum Weight Retention Among Obese Women SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID LONG-TERM OBESITY; PREGNANCY OUTCOMES; PREVALENCE; PATTERN; TRIAL; RISK AB OBJECTIVE: To evaluate the incremental effect of weight gain above that recommended for term pregnancy (15 pounds) on postpartum weight retention at 1 year among obese women. METHODS: In a retrospective cohort study, we identified 1,656 singleton gestations resulting in live births among obese women (body mass index at or above 30 kg/m(2)) between January 2000 and December 2005 in Kaiser Permanente Northwest. Pregnancy weight change (last available predelivery weight minus weight at pregnancy onset) was categorized as less than 0, 0-15, greater than 15 to 25, greater than 25 to 35, and greater than 35 pounds. Postpartum weight change (weight at 1 year postpartum minus weight at pregnancy onset) was defined as less than 0, 0-10, and greater than 10 pounds. RESULTS: Total gestational weight gain was -33.2 (weight loss) to +98.0 pounds (weight gain). Nearly three fourths gained greater than 15 pounds, and they were younger and weighed less at baseline than women who gained 15 pounds or less. Pregnancy-related weight change showed a significant relationship with postpartum weight change. For each pound gained during pregnancy, there was a 0.4-pound increase above baseline weight at 1 year postpartum. In adjusted logistic regression models, the risk of a postpartum weight greater than 10 pounds over baseline was twofold higher for women gaining greater than 15 to 25 pounds compared with women gaining 0-15 pounds (odds ratio [OR] 2.18, 95% confidence interval [CI] 1.54-3.10), fourfold higher for women gaining greater than 25 to 35 pounds (OR 3.91, 95% CI 2.75-5.56), and almost eightfold higher for women gaining greater than 35 pounds (OR 7.66, 95% CI 5.36-10.97). CONCLUSION: Incremental increases in gestational weight gain beyond the current recommendation for obese women substantially increase the risk of weight retention at 1 year postpartum. (Obstet Gynecol 2009,114:1069-75) C1 [Vesco, Kimberly K.] Kaiser Permanente NW, Ctr Hlth Res, Portland, OR 97227 USA. Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Vesco, KK (reprint author), Kaiser Permanente NW, Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA. EM Kimberly.k.vesco@kpchr.org FU Centers for Disease Control and Prevention [CDC 200-2006-17832] FX Funded by Contract # CDC 200-2006-17832, "Extent of Maternal Morbidity in a Managed Care Setting," from the Centers for Disease Control and Prevention. NR 22 TC 41 Z9 42 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 2009 VL 114 IS 5 BP 1069 EP 1075 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 513AH UT WOS:000271293500016 PM 20168109 ER PT J AU Engineer, FG Keskinocak, P Pickering, LK AF Engineer, Faramroze G. Keskinocak, Pinar Pickering, Larry K. TI Catch-Up Scheduling for Childhood Vaccination SO OPERATIONS RESEARCH LA English DT Article ID PRECEDENCE CONSTRAINTS; MISSED OPPORTUNITIES; IMMUNIZATIONS; MACHINES; JOBS AB In this paper, we outline the development of the core optimization technology used within a decision support tool to help providers and caretakers in constructing catch-up schedules for childhood immunization. These schedules ensure that a child continues to receive timely coverage against vaccine-preventable diseases in the likely event that one or more doses have been delayed. This project was undertaken as part of a collaborative effort between the Centers for Disease Control and Prevention (CDC) and Georgia Institute of Technology. Our aim is to develop a decision support tool that removes from the task of constructing catch-up schedules the tedious combinatorial aspects, while maintaining a level of generality that allows easy accommodation for changes in the existing rules and adding new vaccines to the schedule lineup. We show that the catch-up scheduling problem is NP-hard, and we develop a dynamic programming algorithm that exploits the typical size and structure of the problem to construct optimized schedules almost at the click of a button. In using an optimization-based algorithm, our approach is unique not only in methodology but also in the information, strategy, and advice we can offer to the user. The tool is being advocated by both the CDC and the American Academy of Pediatrics (AAP) as a means of encouraging caretakers and providers to take a more proactive role in ensuring timely vaccination coverage for children, as well as ensuring the accuracy and quality of a catch-up regime. C1 [Engineer, Faramroze G.; Keskinocak, Pinar] Georgia Inst Technol, Sch Ind & Syst Engn, Atlanta, GA 30332 USA. [Pickering, Larry K.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Engineer, FG (reprint author), Georgia Inst Technol, Sch Ind & Syst Engn, Atlanta, GA 30332 USA. EM fenginee@isye.gatech.edu; pinar@isye.gatech.edu; lpickering@cdc.gov FU Health Systems Institute at Georgia Institute of Technology FX The authors are grateful to Cathy Hogan and Shilpa Kottakapu from CDC for their assistance in part of the implementation and the dissemination of the tool. They also thank the associate editor, area editor, and the referees for their insightful comments and suggestions that led to improving the quality of the presentation and further highlighting the contributions of this work. This research is funded in part by a research grant from the Health Systems Institute at Georgia Institute of Technology. NR 31 TC 5 Z9 5 U1 0 U2 7 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 0030-364X J9 OPER RES JI Oper. Res. PD NOV-DEC PY 2009 VL 57 IS 6 BP 1307 EP 1319 DI 10.1287/opre.1090.0756 PG 13 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 533BX UT WOS:000272798200001 ER PT J AU Hua, W Izurieta, HS Slade, B Belay, ED Haber, P Tiernan, R Woo, EJ Iskander, J Braun, MM Ball, R AF Hua, Wei Izurieta, Hector S. Slade, Barbara Belay, Ermias D. Haber, Penina Tiernan, Rosemary Woo, Emily Jane Iskander, John Braun, M. Miles Ball, Robert TI Kawasaki Disease After Vaccination Reports to the Vaccine Adverse Event Reporting System 1990-2007 SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE Kawasaki disease; vaccine adverse event ID EVENT-REPORTING-SYSTEM; INFANTS; EPIDEMIOLOGY; SAFETY; JAPAN; VAERS; AGE AB Background: Kawasaki disease (KD) is a multisystemic vasculitis primarily affecting children <5 years. A review of RotaTeq (rotavirus vaccine live) clinical trial data revealed higher, though not statistically significantly, KD rates among RotaTeq vaccines than placebo recipients. In June 2007, the RotaTeq label was revised accordingly. Objectives: To describe and assess KD reported to Vaccine Adverse Event Reporting System (VAERS) for all US licensed vaccines. Methods: We reviewed all KD reports received by VAERS from 1990 through mid-October 2007. Cases were characterized by age, gender, onset interval, and vaccine type. Proportional reporting ratio (PRR) was used to evaluate KD reporting for each vaccine compared with all others. Reporting rates were calculated using number of doses distributed as denominator. Results: Through October14, 2007, 107 KD reports were received by VAERS: 26 were categorized as classic cases, 19 atypical, 52 possible, and 10 were noncases. Of the 97 cases, 91 % were children <5 years. There was no clustering of onset intervals after day 1 postvaccination. Before the RotaTeq label revision, the KD PRR was elevated only for Pediarix (DTaP, hepB, and IPV combined) but the KD reporting rate for Pediarix (0.59/100,000 person-years) was much lower than the background incidence rate (9-19/100,000 person-years) for children <5 years in the United States. After the revision, reporting of KD for RotaTeq was stimulated but the reporting rate for RotaTeq (1.47/100,000 person-years) was still much lower than the background rate. Conclusions: Our review does not suggest an elevated KD risk for RotaTeq or other vaccines. Continued postmarketing monitoring for KD is ongoing. C1 [Hua, Wei] FDA, CBER, OBE, Vaccine Safety Branch,Div Epidemiol, Rockville, MD 20852 USA. [Slade, Barbara; Haber, Penina; Iskander, John] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. [Belay, Ermias D.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Tiernan, Rosemary] FDA, CBER, Off Vaccines Res & Review, Rockville, MD 20852 USA. RP Hua, W (reprint author), FDA, CBER, OBE, Vaccine Safety Branch,Div Epidemiol, 1401 Rockville Pike,Suite 264S,HFM-222, Rockville, MD 20852 USA. EM wei.hua@fda.hhs.gov RI Belay, Ermias/A-8829-2013 NR 30 TC 27 Z9 28 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 2009 VL 28 IS 11 BP 943 EP 947 DI 10.1097/INF.0b013e3181a66471 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 512MO UT WOS:000271253800001 PM 19755926 ER PT J AU Payne, DC Szilagyi, PG Staat, MA Edwards, KM Gentsch, JR Weinberg, GA Hall, CB Curns, AT Clayton, H Griffin, MR Fairbrother, G Parashar, UD AF Payne, Daniel C. Szilagyi, Peter G. Staat, Maty Allen Edwards, Kathryn M. Gentsch, Jon R. Weinberg, Geoffrey A. Hall, Caroline B. Curns, Aaron T. Clayton, Haley Griffin, Marie R. Fairbrother, Gerry Parashar, Umesh D. TI Secular Variation in United States Rotavirus Disease Rates and Serotypes Implications for Assessing the Rotavirus Vaccination Program SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE rotavirus; acute gastroenteritis; serotype; emerging strain; G12; rotavirus vaccine; population-based surveillance; variability; New Vaccine Surveillance Network ID POPULATION-BASED SURVEILLANCE; POLYMERASE CHAIN-REACTION; G12 HUMAN ROTAVIRUSES; CHILDREN; STRAINS; EMERGENCE; HOSPITALIZATIONS; INDIA; IDENTIFICATION; G9 AB Background: Since 2006, we have conducted population-based surveillance for rotavirus disease in children seen in hospitals and emergency departments (EDs) in Monroe County, NY (Rochester), Hamilton County, OH (Cincinnati), and Davidson County, TN (Nashville). Methods: During the 2006 and 2007 rotavirus seasons, clinical information and stool specimens were obtained from county children who were <3 years presenting with diarrhea and/or vomiting to the hospital or ED of the only children's hospital in each county. Specimens were tested for rotavirus and genotyped, and rates of hospitalization and ED visits were calculated. Results: While aggregate rotavirus hospitalization rates for the 3 sites were similar in 2006 and 2007 (22.5/10,000 and 26.8/10,000, respectively), individual rates for the 3 counties differed considerably. The rotavirus hospitalization rate in Rochester between 2006 and 2007 increased 3-fold, but decreased by 33% in Cincinnati and 41% in Nashville over the 2 study years. G1 strains accounted for >80% of strains at all 3 sites in 2006. However, in 2007, the uncommon P[8], G 12 strain was detected in 69% of Rochester specimens, while the P[8], G I strain remained predominant in the other 2 sites. No subjects received rotavirus vaccine in 2006 and coverage with 2 to 3 vaccine doses reached 15% in all 3 communities by June 2007. Conclusions: During the 2006 and 2007 rotavirus seasons, with only limited vaccine use, remarkable variability was observed in the population-based rates of severe rotavirus and in the rotavirus serotypes across the 3 sites. This natural secular variability in rotavirus disease must be considered in the assessment of the impact of vaccine on disease rates and rotavirus serotypes. C1 [Payne, Daniel C.; Curns, Aaron T.; Clayton, Haley; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, Atlanta, GA 30333 USA. [Szilagyi, Peter G.; Weinberg, Geoffrey A.; Hall, Caroline B.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA. [Staat, Maty Allen; Fairbrother, Gerry] Univ Cincinnati, Med Ctr, Coll Med, Cincinnati Children Hosp,Dept Pediat, Cincinnati, OH 45267 USA. [Edwards, Kathryn M.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA. [Gentsch, Jon R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. [Clayton, Haley] Atlanta Res & Educ Fdn, Decatur, GA USA. [Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN USA. [Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA. RP Payne, DC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, 1600 Clifton Rd,NE,MS-A47, Atlanta, GA 30333 USA. EM DVP6@cdc.gov NR 26 TC 56 Z9 57 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 2009 VL 28 IS 11 BP 948 EP 953 DI 10.1097/INF.0b013e3181a6ad6e PG 6 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 512MO UT WOS:000271253800002 PM 19859013 ER PT J AU Civen, R Chaves, SS Jumaan, A Wu, H Mascola, L Gargiullo, P Seward, JF AF Civen, Rachel Chaves, Sandra S. Jumaan, Aisha Wu, Han Mascola, Laurene Gargiullo, Paul Seward, Jane F. TI The Incidence and Clinical Characteristics of Herpes Zoster Among Children and Adolescents After Implementation of Varicella Vaccination SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE herpes zoster; varicella vaccine; varicella-zoster virus; impact of varicella vaccination; herpes zoster incidence; active surveillance ID UNITED-STATES; MASS VACCINATION; VIRUS-INFECTION; EPIDEMIOLOGY; CHICKENPOX; RISK; IMMUNIZATION; LEUKEMIA; IMMUNITY; SAFETY AB Background: The varicella-zoster virus (VZV) vaccine strain may reactivate to cause herpes zoster. Limited data suggest that the risk of herpes zoster in vaccinated children could be lower than in children with naturally acquired varicella. We examine incidence trends, risk and epidemiologic and clinical features of herpes zoster disease among children and adolescents by vaccination status. Methods: Population-based active surveillance was conducted among <20 years old residents in Antelope Valley, California, from 2000 through 2006. Structured telephone interviews collected demographic, varicella vaccination and disease histories, and clinical information. Results: From 2000 to 2006, the incidence of herpes zoster among children <10 years of age declined by 55%, from 42 cases reported in 2000 (74.8/100,000 persons; 95% confidence interval [95% CI]: 55.3-101.2) to 18 reported in 2006 (33.3/100,000 - 95% CI: 20.9-52.8; P < 0.001). During the same period, the incidence of herpes zoster among 10- to 19-year-olds increased by 63%, from 35 cases reported in 2000 (59.5/ 100,000 persons; 95% Cl: 42.7-82.9) to 64 reported in 2006 (96.7/ 100,000; 95% CI: 75.7-123.6; P < 0.02). Among children aged <10 years, those with a history of varicella vaccination had a 4 to 12 times lower risk for developing herpes zoster compared with children with history of varicella disease. Conclusions: Varicella vaccine substantially decreases the risk of herpes zoster among vaccinated children and its widespread use will likely reduce overall herpes zoster burden in the United States. The increase in herpes zoster incidence among 10- to 19-year-olds could not be confidently explained and needs to be confirmed from other data sources. C1 [Civen, Rachel; Wu, Han; Mascola, Laurene] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA 90011 USA. [Chaves, Sandra S.; Jumaan, Aisha; Gargiullo, Paul; Seward, Jane F.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Civen, R (reprint author), Los Angeles Cty Dept Publ Hlth, 313 N Figueroa St,Room 212, Los Angeles, CA 90011 USA. EM rciven@la.publichealth.gov NR 36 TC 70 Z9 71 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 2009 VL 28 IS 11 BP 954 EP 959 DI 10.1097/INF.0b013e3181a90b16 PG 6 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 512MO UT WOS:000271253800003 PM 19536039 ER PT J AU Arvelo, W Hinkle, CJ Nguyen, TA Weiser, T Steinmuller, N Khan, F Gladbach, S Parsons, M Jennings, D Zhu, BP Mintz, E Bowen, A AF Arvelo, Wences Hinkle, C. Jon Nguyen, Thai An Weiser, Thomas Steinmuller, Nichole Khan, Fazle Gladbach, Steve Parsons, Michele Jennings, Desmond Zhu, Bao Ping Mintz, Eric Bowen, Anna TI Transmission Risk Factors and Treatment of Pediatric Shigellosis During a Large Daycare Center-Associated Outbreak of Multidrug Resistant Shigella sonnei Implications for the Management of Shigellosis Outbreaks Among Children SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE shigellosis; Shigella sonnei; diarrhea; daycare-center; outbreak; antimicrobial resistance ID UNITED-STATES; CHILDREN; FLUOROQUINOLONES; COMMUNITY; HYGIENE; ILLNESS; TRIAL AB Background: Shigellosis outbreaks in daycare centers result in substantial disease and economic burdens in the United States. The emergence of multidrug resistant Shigella strains raises questions regarding control of transmission within daycare centers and treatment for children. From May to October 2005, 639 Shigella sonnei cases were reported in northwest Missouri, mostly among persons exposed to daycare centers. Methods: We conducted a case-control investigation among licensed daycare centers (LDCs) in northwest Missouri to determine transmission risk factors, tested isolates for antimicrobial resistance, and described treatment practices. Case LDCs had secondary attack rates of shigellosis >= 2% (range, 2%-25%) and control LDCs <= 2% (range, 0%-1.3%). We interviewed LDC staff and performed on-site inspections. Thirty-one outbreak isolates were tested for antimicrobial resistance. We interviewed physicians and reviewed health department outbreak-related treatment data. Results: We enrolled 18 case and 21 control LDCs. LDCs with >= 1 sink in every room (odds ratio [OR]: 0.1; 95% confidence interval [CI]: 0.02-0.5) or a diapering station in every room (OR: 0.1; 95% CI: 0.01-0.6) were less likely to be case-LDCs. Resistance to ampicillin and trimethoprim-sulfamethoxazole was found in 90% of the outbreak strains. Among 210 children treated with antimicrobial agents, azithromycin was used in 92 (44%) while a fluoroquinolone was used in 11 (5%) children. Conclusions: During a large daycare center-associated shigellosis outbreak, strains were highly resistant to ampicillin and trimethoprim-sulfamethoxazole. Children were frequently treated with azithromycin and occasionally fluoroquinolones. Appropriate handwashing and diapering infrastructure are necessary to minimize spread of shigellosis within daycare centers, and could reduce use of antimicrobial agents. C1 [Arvelo, Wences; Nguyen, Thai An; Steinmuller, Nichole; Parsons, Michele; Jennings, Desmond; Mintz, Eric; Bowen, Anna] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Div Foodborne Bacterial & Mycot Dis, Enter Dis Epidemiol Branch, Atlanta, GA 30329 USA. [Arvelo, Wences; Weiser, Thomas] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30329 USA. [Hinkle, C. Jon; Weiser, Thomas; Khan, Fazle; Gladbach, Steve; Zhu, Bao Ping] Missouri State Dept Hlth & Senior Serv, Jefferson City, MO USA. RP Bowen, A (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Div Foodborne Bacterial & Mycot Dis, Enter Dis Epidemiol Branch, Clifton Bldg 1,Room 5426,MS A-38, Atlanta, GA 30329 USA. EM aqb0@cdc.gov NR 31 TC 16 Z9 17 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 2009 VL 28 IS 11 BP 976 EP 980 DI 10.1097/INF.0b013e3181a76eab PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 512MO UT WOS:000271253800007 PM 19738503 ER PT J AU Cheung, YB Zaman, SMA Nsekpong, ED Van Beneden, CA Adegbola, RA Greenwood, B Cutts, FT AF Cheung, Yin-Bun Zaman, Syed M. A. Nsekpong, Ekpedeme David Van Beneden, Chris A. Adegbola, Richard A. Greenwood, Brian Cutts, Felicity T. TI Nasopharyngeal Carriage of Streptococcus pneumoniae in Gambian Children who Participated in a 9-valent Pneumococcal Conjugate Vaccine Trial and in Their Younger Siblings SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE antibiotic resistance; carriage; conjugate vaccine; Streptococcus pneumoniae ID ACUTE OTITIS-MEDIA; DAY-CARE-CENTERS; INVASIVE-DISEASE; DEVELOPING-WORLD; SEROTYPE 19A; IMMUNOGENICITY; COLONIZATION; POPULATION; EFFICACY; IMPACT AB Background: Nasopharyngeal carriage of Streptococcus pneumoniae is extremely prevalent in The Gambia. We studied the effects of vaccination with pneumococcal conjugate vaccines on the carriage of individual serotypes and on antimicrobial resistance in vaccinated children and their younger siblings. Methods: A longitudinal study of a subsample of children (n = 2342) who participated in a randomized, placebo controlled trial of a 9-valent pneumococcal conjugate vaccines (PCV-9) in The Gambia, and a crosssectional study of non-PCV-9-vaccinated younger siblings (n = 675). Results: Recipients of PCV-9 were less likely to carry vaccine serotypes 4, 6B, 9V, 14, 19F, and 23F but more likely to carry vaccine-associated 19A and 9 nonvaccine serotypes at approximately 6 months postvaccination (age, 12 months) than were controls (each P < 0.05). At approximately 16 months postvaccination, carriage of vaccine-associated-serotype 6A was also significantly reduced (P < 0.01) while 3 other nonvaccine serotypes were more prevalent in the PCV-9 recipients (each P < 0.05). At 16 months, but not 6 months, postvaccination PCV-9 recipients had lower rate of carrying isolates resistant to tetracycline and trimethoprim-sulfamethoxazole (TMP-SMZ) than controls (risk ratio: 0.90 and 0.95, respectively; each P < 0.05). There was no difference in patterns of carriage of pneumococci in younger siblings of PCV-9 or placebo recipients. Conclusions: The effects of 9-valent pneumococcal conjugate vaccines on carriage of pneumococci persisted for at least 16 months postvaccination in Gambian children. Vaccination had no indirect effect on carriage in younger siblings and there was limited impact on antibiotic resistance. C1 [Cheung, Yin-Bun] Singapore Clin Res Inst, Dept Biostat, Singapore 138669, Singapore. [Cheung, Yin-Bun] Duke NUS Grad Med Sch, Off Clin Sci, Singapore, Singapore. [Nsekpong, Ekpedeme David; Adegbola, Richard A.; Cutts, Felicity T.] MRC Labs, Banjul, Gambia. [Van Beneden, Chris A.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Greenwood, Brian] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London, England. RP Cheung, YB (reprint author), Singapore Clin Res Inst, Dept Biostat, Nanos 02-01,31 biopolis Way, Singapore 138669, Singapore. EM yinbun.cheung@scri.edu.sg FU The Johns Hopkins University; The Boards of the Global Alliance for Vaccines and Immunizations and the Vaccine Fund; MAID; NIH [N01-AI-5477]; Children's Vaccine Program at PATH FX Supported by The Johns Hopkins University with funds provided by The Boards of the Global Alliance for Vaccines and Immunizations and the Vaccine Fund. Also, supported by grants from MAID, NIH through contract N01-AI-5477, and the Children's Vaccine Program at PATH. NR 33 TC 46 Z9 46 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 2009 VL 28 IS 11 BP 990 EP 995 DI 10.1097/INF.0b013e3181a78185 PG 6 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 512MO UT WOS:000271253800010 PM 19536041 ER PT J AU Marano, C Schober, SE Brody, DJ Zhang, C AF Marano, Cinzia Schober, Susan E. Brody, Debra J. Zhang, Cindy TI Secondhand Tobacco Smoke Exposure Among Children and Adolescents: United States, 2003-2006 SO PEDIATRICS LA English DT Article DE secondhand smoke exposure; children's health; National Health and Nutrition Examination Survey; United States ID 3RD NATIONAL-HEALTH; NUTRITION EXAMINATION SURVEY; SERUM COTININE LEVELS; RACIAL-DIFFERENCES; US POPULATION; YOUNG-ADULTS; NONSMOKERS AB OBJECTIVE: The implementation of policies that prohibit tobacco smoking in public places has resulted in a significant reduction in secondhand smoke (SHS) exposure in the US population; however, such policies do not extend to private homes, where children continue to be exposed. Our objective was to assess SHS exposure among US children and adolescents by using serum cotinine measures to compare those who were exposed to SHS in the home and those without home exposure. METHODS: We analyzed serum cotinine data from the 2003-2006 National Health and Nutrition Examination Survey for 5518 children (3-11 years) and nonsmoking adolescents (12-19 years). We calculated geometric mean serum cotinine levels by sociodemographic and household characteristics according to self-reported home SHS exposure. Multiple regression analysis was conducted to evaluate independent predictors of serum cotinine levels. RESULTS: Geometric mean serum cotinine levels were 1.05 ng/mL among those with home SHS exposure and 0.05 ng/mL among those without home exposure. Among children who were exposed to SHS at home, serum cotinine levels were inversely associated with age and were similar for non-Hispanic black and non-Hispanic white children. Conversely, among children without SHS exposure at home, serum cotinine levels were higher among non-Hispanic black compared with non-Hispanic white children, and there was no relationship with age. Mexican American children had the lowest level of SHS exposure. CONCLUSIONS: Serum cotinine levels were an order of magnitude higher among children with reported SHS exposure at home compared with those with no exposure in the home. Pediatrics 2009; 124: 1299 1305 C1 [Marano, Cinzia; Schober, Susan E.; Brody, Debra J.] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Zhang, Cindy] Harris Corp, Falls Church, VA USA. RP Schober, SE (reprint author), CDC, NHANES Program, NCHS, 3311 Toledo Rd,Room 4210, Hyattsville, MD 20782 USA. EM sschober@cdc.gov NR 18 TC 38 Z9 39 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD NOV PY 2009 VL 124 IS 5 BP 1299 EP 1305 DI 10.1542/peds.2009-0880 PG 7 WC Pediatrics SC Pediatrics GA 510MH UT WOS:000271092100006 PM 19841116 ER PT J AU Harris, JR Bergmire-Sweat, D Schlegel, JH Winpisinger, KA Klos, RF Perry, C Tauxe, RV Sotir, MJ AF Harris, Julie R. Bergmire-Sweat, David Schlegel, Julie H. Winpisinger, Kim A. Klos, Rachel F. Perry, Christopher Tauxe, Robert V. Sotir, Mark J. TI Multistate Outbreak of Salmonella Infections Associated With Small Turtle Exposure, 2007-2008 SO PEDIATRICS LA English DT Article DE Salmonella; turtles; children ID REPTILE-ASSOCIATED SALMONELLOSIS; TRACHEMYS-SCRIPTA-ELEGANS; UNITED-STATES; PET TURTLES; PUBLIC-HEALTH; PARATYPHI-B; CHILDREN; ENTERICA; HUMANS AB OBJECTIVE: Turtle-associated salmonellosis was increasingly recognized in the United States during the 1960s, leading to a federal ban in 1975 on the sale of turtles <4 inches in carapace length (small turtles). Although sporadic reports of turtle-associated Salmonella are frequent, outbreaks are rare. In September 2007, several patients with Salmonella enterica serotype Paratyphi B var Java infections reported recent turtle exposure. We conducted an investigation to determine the source and extent of the infections. PATIENTS AND METHODS: Patients with Salmonella Paratyphi B var Java infections with a specific pulsed-field gel electrophoresis pattern (outbreak strain) and illness onset between May 2007 and January 2008, were compared with healthy controls. Reptile exposure and awareness of a Salmonella-reptile link were assessed. Turtle size and purchase information were collected. RESULTS: We identified 107 patients with outbreak-strain infections. The median patient age was 7 years; 33% were hospitalized. Forty-seven (60%) of 78 patients interviewed reported exposure to turtles during the week before illness; 41 (87%) were small turtles, and 16 (34%) were purchased in a retail pet store. In the case-control study, 72% of 25 patients reported turtle exposure during the week before illness compared with 4% of 45 controls (matched odds ratio [mOR]: 40.9 [95% confidence interval (CI): 6.9-unbounded]). Seven (32%) of 22 patients versus 11 (28%) of 39 controls reported knowledge of a link between reptile exposure and Salmonella infection (mOR: 1.3 [95% CI: 0.4-4.6]). CONCLUSIONS: We observed a strong association between turtle exposure and Salmonella infections in this outbreak. Small turtles continue to be sold and pose a health risk, especially to children; many people remain unaware of the link between Salmonella infection and reptile contact. Pediatrics 2009; 124: 1388-1394 C1 [Harris, Julie R.; Perry, Christopher; Tauxe, Robert V.; Sotir, Mark J.] Ctr Dis Control & Prevent, Atlanta, GA 30309 USA. [Harris, Julie R.] Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA. [Bergmire-Sweat, David] N Carolina Div Publ Hlth, Raleigh, NC USA. [Schlegel, Julie H.] S Carolina Dept Hlth & Environm Control, Columbia, SC 29201 USA. [Klos, Rachel F.] Wisconsin Div Publ Hlth, Bur Communicable Dis, Madison, WI USA. [Winpisinger, Kim A.] Ohio Dept Hlth, Columbus, OH 43266 USA. [Perry, Christopher] Childrens Healthcare Atlanta, Atlanta, GA USA. RP Harris, JR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mail Stop A-38, Atlanta, GA 30309 USA. EM ggt5@cdc.gov NR 35 TC 33 Z9 35 U1 1 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD NOV PY 2009 VL 124 IS 5 BP 1388 EP 1394 DI 10.1542/peds.2009-0272 PG 7 WC Pediatrics SC Pediatrics GA 510MH UT WOS:000271092100018 PM 19841114 ER PT J AU Kogan, MD Blumberg, SJ Schieve, LA Boyle, CA Perrin, JM Ghandour, RM Singh, GK Strickland, BB Trevathan, E van Dyck, PC AF Kogan, Michael D. Blumberg, Stephen J. Schieve, Laura A. Boyle, Coleen A. Perrin, James M. Ghandour, Reem M. Singh, Gopal K. Strickland, Bonnie B. Trevathan, Edwin van Dyck, Peter C. TI Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007 SO PEDIATRICS LA English DT Article DE autism spectrum disorder; prevalence; children with special health care needs; disability; national estimates; access to health care ID PERVASIVE DEVELOPMENTAL DISORDERS; EPIDEMIOLOGY; POPULATION; CARE; AGE; HEALTH; TRENDS; IDENTIFICATION; DISABILITIES; MINNESOTA AB OBJECTIVES: The reported increasing prevalence of autism spectrum disorder (ASD) and attendant health and family impact make monitoring of ASD prevalence a public health priority. METHODS: The prevalence of parent-reported diagnosis of ASD among US children aged 3 to 17 years was estimated from the 2007 National Survey of Children's Health (sample size: 78 037). A child was considered to have ASD if a parent/guardian reported that a doctor or other health care provider had ever said that the child had ASD and that the child currently had the condition. The point-prevalence for ASD was calculated for those children meeting both criteria. We examined sociodemographic factors associated with current ASD and with a past (but not current) ASD diagnosis. The health care experiences for children in both ASD groups were explored. RESULTS: The weighted current ASD point-prevalence was 110 per 10,000. We estimate that 673,000 US children have ASD. Odds of having ASD were 4 times as large for boys than girls. Non-Hispanic (NH) black and multiracial children had lower odds of ASD than NH white children. Nearly 40% of those ever diagnosed with ASD did not currently have the condition; NH black children were more likely than NH white children to not have current ASD. Children in both ASD groups were less likely than children without ASD to receive care within a medical home. CONCLUSIONS: The observed point-prevalence is higher than previous US estimates. More inclusive survey questions, increased population awareness, and improved screening and identification by providers may partly explain this finding. Pediatrics 2009; 124: 1395-1403 C1 [Kogan, Michael D.; Ghandour, Reem M.; Singh, Gopal K.; Strickland, Bonnie B.; van Dyck, Peter C.] Maternal & Child Hlth Bur, US Hlth Resources & Serv Adm, US Dept Hlth & Human Serv, Rockville, MD 20857 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, US Dept Hlth & Human Serv, Hyattsville, MD 20782 USA. [Schieve, Laura A.; Boyle, Coleen A.; Trevathan, Edwin] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, US Dept Hlth & Human Serv, Atlanta, GA USA. [Perrin, James M.] Harvard Univ, Sch Med, Mass Gen Hosp Children, Ctr Child & Adolescent Hlth Policy, Boston, MA USA. RP Kogan, MD (reprint author), Maternal & Child Hlth Bur, US Hlth Resources & Serv Adm, US Dept Hlth & Human Serv, 5600 Fishers Lane,Room 18-41, Rockville, MD 20857 USA. EM mkogan@hrsa.gov FU Health Resources and Services Administration, Maternal and Child Health Bureau [UA3 MC 11054] FX Dr Perrin is supported in part by a grant from Autism Speaks and a cooperative agreement from the Health Resources and Services Administration, Maternal and Child Health Bureau (UA3 MC 11054). NR 48 TC 356 Z9 369 U1 3 U2 28 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD NOV PY 2009 VL 124 IS 5 BP 1395 EP 1403 DI 10.1542/peds.2009-1522 PG 9 WC Pediatrics SC Pediatrics GA 510MH UT WOS:000271092100019 PM 19805460 ER PT J AU Binns, HJ Forman, JA Karr, CJ Paulson, JA Osterhoudt, KC Roberts, JR Sandel, MT Seltzer, JM Wright, RO Best, D Blackburn, E Anderson, M Savage, S Rogan, WJ Spire, P Williams, JF Behnke, M Kokotailo, PK Levy, SJ Sims, TH Wunsch, MJ Simkin, D Smith, KS Blythe, MJ Barratt, MS Braverman, PK Murray, PJ Rosen, DS Seigel, WM Wibbelsman, CJ Breech, LL Pinzon, JL Shain, B Smith, KS Moore, KR Bell, JT Etzel, RA Hoffman, BD Ponder, SW Redding, MM Waldron, D Dubray, KL Lund, KJ Saylor, K Storck, MG Holve, SA Thierry, JK Kim, S Kim, S AF Binns, Helen J. Forman, Joel A. Karr, Catherine J. Paulson, Jerome A. Osterhoudt, Kevin C. Roberts, James R. Sandel, Megan T. Seltzer, James M. Wright, Robert O. Best, Dana Blackburn, Elizabeth Anderson, Mark Savage, Sharon Rogan, Walter J. Spire, Paul Williams, Janet F. Behnke, Marylou Kokotailo, Patricia K. Levy, Sharon J. Sims, Tammy H. Wunsch, Martha J. Simkin, Deborah Smith, Karen S. Blythe, Margaret J. Barratt, Michelle S. Braverman, Paula K. Murray, Pamela J. Rosen, David S. Seigel, Warren M. Wibbelsman, Charles J. Breech, Lesley L. Pinzon, Jorge L. Shain, Benjamin Smith, Karen S. Moore, Kelly R. Bell, Joseph T. Etzel, Ruth A. Hoffman, Benjamin D. Ponder, Stephen W. Redding, Mark M. Waldron, Debra Dubray, Kansas L. Lund, Kirsten J. Saylor, Kent Storck, Michael G. Holve, Stephen A. Thierry, Judith K. Kim, Sunnah Kim, Sunnah CA Comm Environm Hlth Comm Subst Abuse Comm Adolescence Comm Native Amer Child Hlth TI Policy Statement-Tobacco Use: A Pediatric Disease SO PEDIATRICS LA English DT Review DE tobacco; smoke; cigarette; environmental tobacco; nicotine; secondhand; smoke free; cigar; smokeless ID CLINICAL PREVENTIVE SERVICES; NICOTINE DEPENDENCE; SMOKING-CESSATION; CIGARETTE-SMOKING; COST-EFFECTIVENESS; UNITED-STATES; MENTAL-HEALTH; ADOLESCENTS; INITIATION; CHILDREN AB Tobacco use and secondhand tobacco-smoke (SHS) exposure are major national and international health concerns. Pediatricians and other clinicians who care for children are uniquely positioned to assist patients and families with tobacco-use prevention and treatment. Understanding the nature and extent of tobacco use and SHS exposure is an essential first step toward the goal of eliminating tobacco use and its consequences in the pediatric population. The next steps include counseling patients and family members to avoid SHS exposures or cease tobacco use; advocacy for policies that protect children from SHS exposure; and elimination of tobacco use in the media, public places, and homes. Three overarching principles of this policy can be identified: (1) there is no safe way to use tobacco; (2) there is no safe level or duration of exposure to SHS; and (3) the financial and political power of individuals, organizations, and government should be used to support tobacco control. Pediatricians are advised not to smoke or use tobacco; to make their homes, cars, and workplaces tobacco free; to consider tobacco control when making personal and professional decisions; to support and advocate for comprehensive tobacco control; and to advise parents and patients not to start using tobacco or to quit if they are already using tobacco. Prohibiting both tobacco advertising and the use of tobacco products in the media is recommended. Recommendations for eliminating SHS exposure and reducing tobacco use include attaining universal (1) smoke-free home, car, school, work, and play environments, both inside and outside, (2) treatment of tobacco use and dependence through employer, insurance, state, and federal supports, (3) implementation and enforcement of evidence-based tobacco-control measures in local, state, national, and international jurisdictions, and (4) financial and systems support for training in and research of effective ways to prevent and treat tobacco use and SHS exposure. Pediatricians, their staff and colleagues, and the American Academy of Pediatrics have key responsibilities in tobacco control to promote the health of children, adolescents, and young adults. Pediatrics 2009; 124: 1474-1487 C1 [Blackburn, Elizabeth] US EPA, Washington, DC 20460 USA. [Anderson, Mark] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Savage, Sharon] NCI, Bethesda, MD 20892 USA. [Rogan, Walter J.] NIEHS, Res Triangle Pk, NC 27709 USA. OI Savage, Sharon/0000-0001-6006-0740 NR 100 TC 66 Z9 68 U1 4 U2 12 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD NOV PY 2009 VL 124 IS 5 BP 1474 EP 1487 DI 10.1542/peds.2009-2114 PG 14 WC Pediatrics SC Pediatrics GA 510MH UT WOS:000271092100028 ER PT J AU Kempe, A Patel, MM Daley, MF Crane, LA Beaty, B Stokley, S Barrow, J Babbel, C Dickinson, LM Tempte, JL Parashar, UD AF Kempe, Allison Patel, Manish M. Daley, Matthew F. Crane, Lori A. Beaty, Brenda Stokley, Shannon Barrow, Jennifer Babbel, Christine Dickinson, L. Miriam Tempte, Jonathan L. Parashar, Umesh D. TI Adoption of Rotavirus Vaccination by Pediatricians and Family Medicine Physicians in the United States SO PEDIATRICS LA English DT Article DE immunization; rotavirus vaccine; physician attitudes ID PNEUMOCOCCAL CONJUGATE VACCINE; NATIONAL-SURVEY; INTUSSUSCEPTION; REIMBURSEMENT; IMMUNIZATION; INFANTS; COST AB OBJECTIVES: The goals were to assess, among pediatricians and family medicine physicians, (1) rates of offering the vaccine in their office; (2) knowledge of Advisory Committee on Immunization Practices recommendations; (3) barriers to use; and (4) factors associated with offering the vaccine. METHODS: Surveys of pediatricians and family medicine physicians were conducted in August to October 2007. RESULTS: Response rates were 84% for pediatricians and 79% for family medicine physicians (N = 623). Proportions routinely offering the vaccine were 85% of pediatricians and 45% of family medicine physicians (P < .0001); 70% of pediatricians and 22% of family medicine strongly recommended the vaccine (P < . 0001). Sixty-two percent of pediatricians and 32% of family medicine physicians (P < .0001) knew the age by which all 3 doses should be completed. Definite barriers to vaccine use included reported lack of coverage by insurance companies (family medicine physicians: 22%; pediatricians: 19%; not significant), costs of purchasing vaccine (family medicine physicians: 22%; pediatricians: 17%; not significant), lack of adequate reimbursement (family medicine physicians: 18%; pediatricians: 15%; not significant), concerns about safety (family medicine physicians: 25%; pediatricians: 9%; P <. 0001), and concerns about adding another vaccine to the schedule (physicians: 22%; pediatricians: 5%; P < .0001). CONCLUSIONS: Rates of offering the new rotavirus vaccine are high among pediatricians but < 50% among family medicine physicians. Both specialties identified financial barriers to use of the vaccine, but family medicine physicians had significantly more concerns about safety and about adding another vaccine to the vaccination schedule. Pediatrics 2009; 124: e809-e816 C1 [Kempe, Allison; Daley, Matthew F.] Univ Colorado Denver, Sch Med, Dept Pediat, Aurora, CO USA. [Dickinson, L. Miriam] Univ Colorado Denver, Sch Med, Dept Family Med, Aurora, CO USA. [Kempe, Allison; Crane, Lori A.] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Hlth Syst Management & Policy, Aurora, CO USA. [Kempe, Allison; Crane, Lori A.] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Community & Behav Hlth, Aurora, CO USA. [Kempe, Allison; Daley, Matthew F.; Beaty, Brenda; Barrow, Jennifer; Babbel, Christine] Univ Colorado Denver, Colorado Hlth Outcomes Program, Aurora, CO USA. [Kempe, Allison; Daley, Matthew F.; Crane, Lori A.; Beaty, Brenda; Barrow, Jennifer; Babbel, Christine] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO USA. [Patel, Manish M.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Atlanta, GA USA. [Stokley, Shannon] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Tempte, Jonathan L.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Family Med, Madison, WI USA. RP Kempe, A (reprint author), Univ Colorado, Childrens Outcomes Res Program, Aurora, CO 80045 USA. EM kempe.allison@tchden.org FU NCCDPHP CDC HHS [5 U48 DP000054-03] NR 24 TC 23 Z9 23 U1 3 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD NOV PY 2009 VL 124 IS 5 BP E809 EP E816 DI 10.1542/peds.2008-3832 PG 8 WC Pediatrics SC Pediatrics GA 510MH UT WOS:000271092100031 PM 19822592 ER PT J AU Johansson, MA Cummings, DAT Glass, GE AF Johansson, Michael A. Cummings, Derek A. T. Glass, Gregory E. TI Multiyear Climate Variability and Dengue-El Nino Southern Oscillation, Weather, and Dengue Incidence in Puerto Rico, Mexico, and Thailand: A Longitudinal Data Analysis SO PLOS MEDICINE LA English DT Article ID SPACE-TIME CLIMATE; AEDES-AEGYPTI; DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; TRAVELING-WAVES; TRANSMISSION; EPIDEMICS; VIRUS; SERIES; TEMPERATURE AB Background: The mosquito-borne dengue viruses are a major public health problem throughout the tropical and subtropical regions of the world. Changes in temperature and precipitation have well-defined roles in the transmission cycle and may thus play a role in changing incidence levels. The El Nino Southern Oscillation (ENSO) is a multiyear climate driver of local temperature and precipitation worldwide. Previous studies have reported varying degrees of association between ENSO and dengue incidence. Methods and Findings: We analyzed the relationship between ENSO, local weather, and dengue incidence in Puerto Rico, Mexico, and Thailand using wavelet analysis to identify time-and frequency-specific association. In Puerto Rico, ENSO was transiently associated with temperature and dengue incidence on multiyear scales. However, only local precipitation and not temperature was associated with dengue on multiyear scales. In Thailand, ENSO was associated with both temperature and precipitation. Although precipitation was associated with dengue incidence, the association was nonstationary and likely spurious. In Mexico, no association between any of the variables was observed on the multiyear scale. Conclusions: The evidence for a relationship between ENSO, climate, and dengue incidence presented here is weak. While multiyear climate variability may play a role in endemic interannual dengue dynamics, we did not find evidence of a strong, consistent relationship in any of the study areas. The role of ENSO may be obscured by local climate heterogeneity, insufficient data, randomly coincident outbreaks, and other, potentially stronger, intrinsic factors regulating transmission dynamics. C1 [Johansson, Michael A.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Dengue Branch, San Juan, PR USA. [Johansson, Michael A.; Glass, Gregory E.] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. RP Johansson, MA (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Dengue Branch, San Juan, PR USA. EM mjohansson@cdc.gov FU US Centers for Disease Control and Prevention; Burroughs Wellcome Career Award FX Derek Cummings holds a Burroughs Wellcome Career Award at the Scientific Interface. NR 37 TC 95 Z9 97 U1 8 U2 26 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD NOV PY 2009 VL 6 IS 11 AR e1000168 DI 10.1371/journal.pmed.1000168 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 522XC UT WOS:000272032500007 PM 19918363 ER PT J AU Muller, T Dietzschold, B Ertl, H Fooks, AR Freuling, C Fehlner-Gardiner, C Kliemt, J Meslin, FX Rupprecht, CE Tordo, N Wanderler, AI Kieny, MP AF Mueller, Thomas Dietzschold, Bernhard Ertl, Hildegund Fooks, Anthony R. Freuling, Conrad Fehlner-Gardiner, Christine Kliemt, Jeannette Meslin, Francois X. Rupprecht, Charles E. Tordo, Noel Wanderler, Alexander I. Kieny, Marie Paule TI Development of a Mouse Monoclonal Antibody Cocktail for Post-exposure Rabies Prophylaxis in Humans SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Editorial Material ID CAUCASIAN-BAT-VIRUSES; IMMUNE GLOBULIN; NEUTRALIZING ANTIBODY; GLYCOPROTEIN; VACCINE; LYSSAVIRUSES; COMBINATION; MECHANISMS; AFRICA; IRKUT AB As the demand for rabies post-exposure prophylaxis (PEP) treatments has increased exponentially in recent years, the limited supply of human and equine rabies immunoglobulin (HRIG and ERIG) has failed to provide the required passive immune component in PEP in countries where canine rabies is endemic. Replacement of HRIG and ERIG with a potentially cheaper and efficacious alternative biological for treatment of rabies in humans, therefore, remains a high priority. In this study, we set out to assess a mouse monoclonal antibody (MoMAb) cocktail with the ultimate goal to develop a product at the lowest possible cost that can be used in developing countries as a replacement for RIG in PEP. Five MoMAbs, E559.9.14, 1112-1, 62-71-3, M727-5-1, and M777-16-3, were selected from available panels based on stringent criteria, such as biological activity, neutralizing potency, binding specificity, spectrum of neutralization of lyssaviruses, and history of each hybridoma. Four of these MoMAbs recognize epitopes in antigenic site II and one recognizes an epitope in antigenic site III on the rabies virus (RABV) glycoprotein, as determined by nucleotide sequence analysis of the glycoprotein gene of unique MoMAb neutralization-escape mutants. The MoMAbs were produced under Good Laboratory Practice (GLP) conditions. Unique combinations (cocktails) were prepared, using different concentrations of the MoMAbs that were capable of targeting non-overlapping epitopes of antigenic sites II and III. Blind in vitro efficacy studies showed the MoMab cocktails neutralized a broad spectrum of lyssaviruses except for lyssaviruses belonging to phylogroups II and III. In vivo, MoMAb cocktails resulted in protection as a component of PEP that was comparable to HRIG. In conclusion, all three novel combinations of MoMAbs were shown to have equal efficacy to HRIG and therefore could be considered a potentially less expensive alternative biological agent for use in PEP and prevention of rabies in humans. C1 [Mueller, Thomas; Freuling, Conrad; Kliemt, Jeannette] WHO Collaborating Ctr Rabies Surveillance Res, Fed Res Inst Anim Hlth, Friedrich Loeffler Inst, Wusterhausen, Germany. Thomas Jefferson Univ, Dept Microbiol & Immunol, WHO Collaborating Ctr Neurovirol, Philadelphia, PA 19107 USA. [Ertl, Hildegund] WHO Collaborating Ctr Reference & Res Rabies, Wistar Inst, Philadelphia, PA USA. [Fooks, Anthony R.] WHO Collaborating Ctr Characterizat Rabies & Rabl, Vet Labs Agcy, Dept Virol, Surrey, England. [Fehlner-Gardiner, Christine; Wanderler, Alexander I.] WHO Collaborating Ctr Rabies Control Pathogenesis, Canadian Food Inspect Agcy, Ctr Expertise Rabies, Ottawa, ON, Canada. [Meslin, Francois X.] World Hlth Org, NZD, Dept Neglected Trop Dis NTD, Cluster HIV AIDS Malaria TB & Neglected Trop Dis, Geneva, Switzerland. [Rupprecht, Charles E.] Ctr Dis Control & Prevent, WHO Collaborating Ctr Reference & Res Rabies, Rabies Sect, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Rupprecht, Charles E.] Ctr Dis Control & Prevent, Viral & Rickettsial Zoonoses Branch, Natl Ctr Infect Dis, Atlanta, GA USA. [Tordo, Noel] Inst Pasteur, Rabies Unit, Unit Antiviral Strategy, CNRS URA 3015, Paris, France. [Kieny, Marie Paule] World Hlth Org, Initiat Vaccine Res Vaccines & Biol Hlth Technol, Geneva, Switzerland. RP Muller, T (reprint author), WHO Collaborating Ctr Rabies Surveillance Res, Fed Res Inst Anim Hlth, Friedrich Loeffler Inst, Wusterhausen, Germany. EM Kienym@who.int RI APHA, Staff publications/E-6082-2010; Fooks, Anthony/F-5418-2010 NR 51 TC 43 Z9 46 U1 0 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD NOV PY 2009 VL 3 IS 11 AR e542 DI 10.1371/journal.pntd.0000542 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 522XG UT WOS:000272032900004 PM 19888334 ER PT J AU Chan, L Wang, H Terdiman, J Hoffman, J Ciol, MA Lattimore, BF Sidney, S Quesenberry, C Lu, Q Sandel, ME AF Chan, Leighton Wang, Hua Terdiman, Joe Hoffman, Jeanne Ciol, Marcia A. Lattimore, Bernadette Ford Sidney, Steven Quesenberry, Charles Lu, Qi Sandel, M. Elizabeth TI Disparities in Outpatient and Home Health Service Utilization Following Stroke: Results of a 9-Year Cohort Study in Northern California SO PM&R LA English DT Article AB Objective: To examine whether there are disparities in utilization of outpatient and home care services after stroke. Design: Retrospective cohort study. Setting: The Kaiser Permanente of Northern California health care system, which provides health care for approximately 3.3 million members. Participants: A total of 11,119 patients hospitalized for a stroke between 1996 and 2003 and followed for 1 year. Main Outcome Measures: Receipt of outpatient rehabilitation (physical therapy, occupational therapy, speech pathology, or physical medicine and rehabilitation/physiatry visits), and/or home health care. Results: There were significant differences in outpatient rehabilitation visits and home health enrollment during the year after acute care discharge for all the parameters under study. Older age and female gender were associated with less outpatient rehabilitation treatment, but these subpopulations were more likely to be enrolled in home health care. Non-whites, patients from urban areas, those with ischemic strokes, and those with longer acute care hospital stays had relatively more outpatient rehabilitation and were also more likely to be enrolled in the home health program. In addition, patients living in geographic areas with a median household income of $80,000 or more had significantly more outpatient rehabilitation visits than did patients living in lower income areas. Conclusions: Variations in outpatient rehabilitation visits and in home health care exist in this large integrated health system in terms of age, gender, race/ethnicity, residence area, type of stroke, and length of stay in an acute care hospital. The Kaiser Permanente integrated health care system seems to have outpatient stroke rehabilitation and home health programs that are providing care without disparities in relation to non-white populations, but other disparities appear to exist that may be related to socioeconomic factors, referral patterns, family support systems, or other cultural factors that have not been identified. C1 [Chan, Leighton] NIH Clin Ctr, Dept Rehabil Med, Bethesda, MD 20892 USA. [Wang, Hua; Sandel, M. Elizabeth] Kaiser Fdn Rehabil Ctr, Dept Phys Med & Rehabil, Vallejo, CA USA. [Terdiman, Joe; Sidney, Steven] Kaiser Permanente Div Res, Oakland, CA USA. [Hoffman, Jeanne; Ciol, Marcia A.] Univ Washington, Seattle, WA 98195 USA. [Lattimore, Bernadette Ford] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lu, Qi] Kaiser Fdn Rehabil Ctr, Kaiser Permanente Div Res, Vallejo, CA USA. RP Chan, L (reprint author), NIH Clin Ctr, Dept Rehabil Med, Bldg 10,CRC,Room 1-1469,10 Ctr Dr,MSC 1604, Bethesda, MD 20892 USA. EM chanle@cc.nih.gov FU Centers for Disease Control and Prevention FX This study supported by funding from the Centers for Disease Control and Prevention. Additional resources were provided by the Intramural Research Program of (Clinical Research Center) the National Institutes of Health, the Centers for Medicare and Medicaid Services, and Kaiser Permanente. NR 28 TC 16 Z9 16 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 J9 PM&R JI PM&R PD NOV PY 2009 VL 1 IS 11 BP 997 EP 1003 DI 10.1016/j.pmrj.2009.09.019 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA V24LO UT WOS:000208412100003 PM 19942185 ER PT J AU Rehm, SJ Farley, MM File, TM Hall, WJ Hopkins, R Levine, OS Nichol, KL Nuorti, P Zimmerman, RK Schaffner, W AF Rehm, Susan J. Farley, Monica M. File, Thomas M., Jr. Hall, William J. Hopkins, Robert Levine, Orin S. Nichol, Kristin L. Nuorti, Pekka Zimmerman, Richard K. Schaffner, William TI Higher Pneumococcal Disease Vaccination Rates Needed to Protect More At-Risk US Adults SO POSTGRADUATE MEDICINE LA English DT Article DE pneumococcal disease; PPSV23; H1N1 influenza; community-acquired pneumonia; invasive pneumococcal disease ID COMMUNITY-ACQUIRED PNEUMONIA; CONJUGATE VACCINE; UNITED-STATES; OLDER-ADULTS; CHANGING EPIDEMIOLOGY; MENINGITIS AB Pneumococcal disease, which includes pneumococcal pneumonia, meningitis, and bacteremia, is associated with substantial morbidity, mortality, and health care costs in adults. Advanced age, chronic lung or cardiovascular disease, immunosuppressive conditions, and smoking increase the risk for infection. Despite the availability of an effective pneumococcal polysaccharide vaccine (PPSV23), vaccination rates among adults remain suboptimal. This is of immediate concern given the current H1N1 pandemic, since secondary bacterial infection with Streptococcus pneumoniae is common and can contribute to morbidity and mortality. The Centers for Disease Control and Prevention has recently called for increased efforts to vaccinate recommended persons against pneumococcal disease. Long-term trends including the growth of the elderly population and an increase in the number of patients with chronic conditions also underscore the importance of improving pneumococcal vaccination rates. It is important for health care providers, public health officials, and policy makers to recognize the serious health impact of pneumococcal disease in adults and to ensure increased coverage; at present, this is the best way to protect against invasive pneumococcal infection and its consequences. C1 [Rehm, Susan J.] Cleveland Clin, Dept Infect Dis, Cleveland, OH 44195 USA. [Rehm, Susan J.; File, Thomas M., Jr.; Schaffner, William] Natl Fdn Infect Dis, Bethesda, MD USA. [Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA USA. [File, Thomas M., Jr.] Northeastern Ohio Univ Coll Med & Pharm, Rootstown, OH 44272 USA. [Hall, William J.] Univ Rochester, Sch Med, Rochester, NY USA. [Hopkins, Robert] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Levine, Orin S.] Johns Hopkins Univ, Baltimore, MD USA. [Levine, Orin S.] Emory Univ, Atlanta, GA 30322 USA. [Nichol, Kristin L.] Univ Minnesota, Minneapolis VA Med Ctr, Minneapolis, MN USA. [Nuorti, Pekka] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nuorti, Pekka] Univ Tampere, FIN-33101 Tampere, Finland. [Zimmerman, Richard K.] Univ Pittsburgh, Pittsburgh, PA USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Rehm, SJ (reprint author), Cleveland Clin, Dept Infect Dis, 9500 Euclid Ave,S-32, Cleveland, OH 44195 USA. EM rehms@ccf.org OI Zimmerman, Richard/0000-0001-5941-6092 FU Wyeth Pharmaceuticals FX The authors of this statement comprise the National Foundation for Infectious Diseases'(NFID) Pneumococcal Disease Advisory Board. The Board and its efforts are supported through an unrestricted educational grant to NFID from Wyeth Pharmaceuticals. Editorial support for this statement was provided by Alembic Health Communications. Authors are collectively responsible for the content of this statement. NR 31 TC 14 Z9 15 U1 0 U2 2 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD NOV PY 2009 VL 121 IS 6 BP 101 EP 105 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 527LY UT WOS:000272369800009 PM 19940420 ER PT J AU Cheng, YJ Gregg, EW Saaddine, JB Imperatore, G Zhang, XZ Albright, AL AF Cheng, Yiling J. Gregg, Edward W. Saaddine, Jinan B. Imperatore, Giuseppina Zhang, Xinzhi Albright, Ann L. TI Three decade change in the prevalence of hearing impairment and its association with diabetes in the United States SO PREVENTIVE MEDICINE LA English DT Article DE Diabetes mellitus; Hearing impairment; National population survey; Prevalence; Trend change ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; NEUROPATHY; ADULTS; POPULATION; MELLITUS AB Objective. To examine the secular change of the prevalence of hearing impairment over three decades in U.S. adults with and without diabetes. Methods. The cross-sectional National Health and Nutrition Examination Surveys (NHANES, the 1971-1973 [NHANES 11 and the 1999-2004 [NHANES 1999-2004]) were used. Average pure-tone audiometry thresholds in decibels (0) at 1, 2, 3, and 4 kHz frequencies of the worse ear were used to represent the participants' hearing status. Any hearing impairment was defined as average pure-tone audiometry threshold of the worse ear >25 dB. Results. From 1971 to 2004, among adults without diabetes aged 25 to 69 years, the unadjusted prevalence of hearing impairment decreased from 27.9% to 19.1% (P<0.001), but among adults with diabetes there was no significant change (46.4% to 48.5%). After adjustment forage, sex, race, and education, the prevalence of hearing impairment in the NHANES I and NHANES 1999-2004, respectively, was 24.4% (95% confidence interval 101, 22.3-26.6%) and 22.3% (95% Cl, 20.4-24.2) for adults without diabetes and 28.5% (95% Cl, 20.4-36.6%) and 34.4 (95% Cl, 29.1-39.7%) for adults with diabetes. The adjusted prevalence ratios of hearing impairment for persons with diabetes vs. those without diabetes was 1.17 (95% Cl, 0.87-1.57) for the NHANES I and 1.53 (95% Cl, 1.28-1.83) for NHANES 1999-2004. Conclusions. Persons with diabetes have a higher prevalence of hearing impairment, and they have not achieved the same reductions in hearing impairment over time as have persons without diabetes. Published by Elsevier Inc. C1 [Cheng, Yiling J.; Gregg, Edward W.; Saaddine, Jinan B.; Imperatore, Giuseppina; Zhang, Xinzhi; Albright, Ann L.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Cheng, YJ (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-10, Atlanta, GA 30341 USA. EM ycheng@cdc.gov NR 27 TC 18 Z9 20 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD NOV PY 2009 VL 49 IS 5 BP 360 EP 364 DI 10.1016/j.ypmed.2009.07.021 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 520MQ UT WOS:000271849200003 PM 19664652 ER PT J AU Gustafson, A Khavjou, O Stearns, SC Keyserling, TC Gizlice, Z Lindsley, S Bramble, K Garcia, B Johnston, L Will, J Poindexter, P Ammerman, AS Samuel-Hodge, CD AF Gustafson, Alison Khavjou, Olga Stearns, Sally C. Keyserling, Thomas C. Gizlice, Ziya Lindsley, Sara Bramble, Kathy Garcia, Beverly Johnston, Larry Will, Julie Poindexter, Patricia Ammerman, Alice S. Samuel-Hodge, Carmen D. TI Cost-effectiveness of a behavioral weight loss intervention for low-income women: The Weight-Wise Program SO PREVENTIVE MEDICINE LA English DT Article DE Cost-effectiveness; Weight loss; Intervention ID ECONOMIC-EVALUATION; OBESITY; WISEWOMAN; TRIAL; CONSEQUENCES; ASSOCIATION; OVERWEIGHT; ORLISTAT; OUTCOMES; RISK AB Objective. Assess the cost-effectiveness of a 16-week weight loss intervention (Weight-Wise) for low-income midlife women. Method. A randomized controlled trial conducted in North Carolina in 2007 tested a weight loss intervention among 143 women (40-64 years old, mean BMI = 35.1 kg/m(2)). Women were randomized to one of two arms-special intervention (n = 72) and a wait-listed control group (n = 7 1). Effectiveness measures included changes in weight, systolic and diastolic blood pressure, total cholesterol, and HDL cholesterol. Cost-effectiveness measures calculated life years gained (LYG) from changes in weight, based on excess years life lost (YLL) algorithm. Results. Intervention participants had statistically significant decreases in weight (kg) (-4.4 95% CI = -5.6, -3.2) and in systolic blood pressure (-6.2 mm Hg, 95% CI = -10.6, -1.7) compared to controls. Total cost of conducting Weight-Wise was $17,403, and the cost per participant in intervention group was $242. The incremental cost per life year gained (discounted) from a decrease in obesity was $1862. Conclusion. our results suggest the Weight-Wise intervention may be a cost-effective approach to improving the health of low-income women. (C) 2009 Elsevier Inc. All rights reserved. C1 [Gustafson, Alison; Ammerman, Alice S.; Samuel-Hodge, Carmen D.] Univ N Carolina, Sch Med, Dept Nutr, Chapel Hill, NC 27519 USA. [Gustafson, Alison; Ammerman, Alice S.; Samuel-Hodge, Carmen D.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27519 USA. [Khavjou, Olga] RTI Int, Hlth Social & Econ Res, Res Triangle Pk, NC USA. [Stearns, Sally C.] Univ N Carolina, Sch Publ Hlth, Dept Hlth Policy & Management, Chapel Hill, NC 27519 USA. [Keyserling, Thomas C.] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27519 USA. [Gizlice, Ziya; Lindsley, Sara; Bramble, Kathy; Garcia, Beverly; Johnston, Larry; Ammerman, Alice S.; Samuel-Hodge, Carmen D.] Univ N Carolina, UNC Ctr Hlth Promot & Dis Prevent, Chapel Hill, NC 27519 USA. [Will, Julie; Poindexter, Patricia] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Gustafson, A (reprint author), Univ N Carolina, Sch Med, MPH Dept Nutr, NC 1700 MLK, Chapel Hill, NC 27519 USA. EM agustafs@email.unc.edu FU Centers for Disease Control and Prevention (CDC) [U48/CCU422824-04]; UNC Center for Health Promotion and Disease Prevention; NC Department of Health and Human Services; New Hanover Community Health Center; Grace United Methodist Church; NIH [DK56350] FX This study was supported by cooperative agreement number U48/CCU422824-04 with the Centers for Disease Control and Prevention (CDC) and conducted through partnerships among the UNC Center for Health Promotion and Disease Prevention, the NC Department of Health and Human Services, the New Hanover Community Health Center, and the Grace United Methodist Church. Other support was provided by the UNC Nutrition Epidemiology Core through funding by NIH Grant DK56350. We are indebted to all the agency partners, study volunteers, and the women of Weight-Wise, whose involvement made this study possible. NR 37 TC 9 Z9 9 U1 2 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD NOV PY 2009 VL 49 IS 5 BP 390 EP 395 DI 10.1016/j.ypmed.2009.09.007 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 520MQ UT WOS:000271849200008 PM 19747937 ER PT J AU Safran, MA AF Safran, Marc A. TI Achieving Recognition That Mental Health is Part of the Mission of CDC SO PSYCHIATRIC SERVICES LA English DT Article AB For much of its history the U.S. Centers for Disease Control and Prevention (CDC) considered mental health to be outside of its mission. That assumption persisted even after CDC became a leading public health agency and began to face important mental health issues. This narrative describes how the organizational paradigm indicating that mental health was not mission related was challenged and superseded by a new paradigm recognizing mental health as part of CDC's public health mission. Even after the CDC Mental Health Work Group's establishment in 2000, CDC took eight more years to overcome powerful remnants of the old paradigm that had for so long excluded, minimized, or discouraged attention to mental health. The CDC Mental Health Work Group led the agency's mental health efforts without funding or dedicated staffing but with more than 100 CDC professionals from multiple disciplines and centers serving as voluntary members, in addition to their other CDC responsibilities. (Psychiatric Services 60: 1532-1534, 2009) C1 [Safran, Marc A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Safran, MA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM msafran@cdc.gov NR 9 TC 4 Z9 4 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD NOV PY 2009 VL 60 IS 11 BP 1532 EP 1534 PG 3 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 514KM UT WOS:000271393200022 PM 19880474 ER PT J AU Hammond, WR Haegerich, TM Saul, J AF Hammond, W. Rodney Haegerich, Tamara M. Saul, Janet TI The Public Health Approach to Youth Violence and Child Maltreatment Prevention at the Centers for Disease Control and Prevention SO PSYCHOLOGICAL SERVICES LA English DT Article DE violence; public health; Centers for Disease Control and Prevention; youth violence; child maltreatment AB Millions of people in the United States suffer the consequences of violence, including physical injuries, psychological trauma, and death. Solutions to violence have traditionally been reactive. Through the lens of the public health perspective, the Centers for Disease Control and Prevention (CDC) views violence as predictable based on various contributing factors, and thus as preventable. Within CDC, the Division of Violence Prevention (DVP) leads efforts to prevent injury, death, and disability, and to reduce the suffering and medical costs caused by violence. DVP employs a multidisciplinary, public health approach to identify factors associated with violence, and to develop, evaluate, and disseminate preventive interventions. Psychology is one discipline that has contributed to our approach. The authors present a series of violence prevention initiatives funded by the CDC that are framed within a public health perspective, with attention to the contributions of psychology to youth violence and child maltreatment prevention. C1 [Hammond, W. Rodney; Haegerich, Tamara M.; Saul, Janet] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Hammond, WR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop K68, Atlanta, GA 30341 USA. EM rih2@cdc.gov NR 56 TC 2 Z9 2 U1 1 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 J9 PSYCHOL SERV JI Psychol. Serv. PD NOV PY 2009 VL 6 IS 4 BP 253 EP 263 DI 10.1037/a0016986 PG 11 WC Psychology, Clinical SC Psychology GA V17YC UT WOS:000207971500002 ER PT J AU Gaffga, NH Samuel, MC Stenger, MR Stover, JA Newman, LM AF Gaffga, Nicholas H. Samuel, Michael C. Stenger, Mark R. Stover, Jeffrey A. Newman, Lori M. TI The OASIS Project: Novel Approaches to Using STD Surveillance Data SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Gaffga, Nicholas H.] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Samuel, Michael C.] Calif Dept Publ Hlth, Div Communicable Dis Control, STD Control Branch, Richmond, CA USA. [Stenger, Mark R.] Washington State Dept Hlth, Infect Dis & Reprod Hlth Assessment Unit, Olympia, WA USA. [Stover, Jeffrey A.] Virginia Dept Hlth, Div Dis Prevent, Richmond, VA USA. [Stover, Jeffrey A.] Virginia Commonwealth Univ, Sch Med, Dept Epidemiol & Community Hlth, Richmond, VA USA. RP Gaffga, NH (reprint author), Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM ngaffga@cdc.gov NR 25 TC 4 Z9 4 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 1 EP 4 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200001 ER PT J AU Weinstock, H Douglas, JM Fenton, KA AF Weinstock, Hillard Douglas, John M., Jr. Fenton, Kevin A. TI Toward Integration of STD, HIV, TB, and Viral Hepatitis Surveillance SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Weinstock, Hillard] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30332 USA. RP Weinstock, H (reprint author), Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30332 USA. EM hsw2@cdc.gov NR 5 TC 4 Z9 4 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 5 EP 6 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200002 PM 27382648 ER PT J AU Newman, LM Samuel, MC Stenger, MR Gerber, TM Macomber, K Stover, JA Wise, W AF Newman, Lori M. Samuel, Michael C. Stenger, Mark R. Gerber, Todd M. Macomber, Kathryn Stover, Jeffrey A. Wise, Wendy TI Practical Considerations for Matching STD and HIV Surveillance Data with Data from Other Sources SO PUBLIC HEALTH REPORTS LA English DT Article ID PROBABILISTIC RECORD LINKAGE; STRATEGIES AB Data to guide programmatic decisions in public health are needed, but frequently epidemiologists are limited to routine case report data for notifiable conditions such as sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV). However, case report data are frequently incomplete or provide limited information on comorbidity or risk factors. Supplemental data often exist but are not easily accessible, due to a variety of real and perceived obstacles. Data matching, defined as the linkage of records across two or more data sources, can be a useful method to obtain better or additional data, using existing resources. This article reviews the practical considerations for matching STD and HIV surveillance data with other data sources, including examples of how STD and HIV programs have used data matching. C1 [Newman, Lori M.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Samuel, Michael C.] Calif Dept Publ Hlth, STD Control Branch, Div Communicable Dis Control, Richmond, CA USA. [Stenger, Mark R.] Washington State Dept Hlth, Olympia, WA USA. [Gerber, Todd M.] New York State Dept Hlth, Div Family Hlth, Albany, NY USA. [Macomber, Kathryn] Michigan Dept Community Hlth, Bur Epidemiol, Lansing, MI USA. [Stover, Jeffrey A.] Virginia Dept Hlth, Div Dis Prevent, Off Epidemiol, Richmond, VA USA. [Stover, Jeffrey A.] Virginia Commonwealth Univ, Dept Epidemiol & Community Hlth, Sch Med, Richmond, VA USA. [Wise, Wendy] Ohio Dept Hlth, STD TB Surveillance, Columbus, OH 43266 USA. RP Newman, LM (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM len4@cdc.gov NR 32 TC 10 Z9 10 U1 0 U2 2 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 7 EP 17 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200003 PM 27382649 ER PT J AU Dowell, D Gaffga, NH Weinstock, H Peterman, TA AF Dowell, Deborah Gaffga, Nicholas H. Weinstock, Hillard Peterman, Thomas A. TI Integration of Surveillance for STDs, HIV, Hepatitis, and TB: A Survey of US STD Control Programs SO PUBLIC HEALTH REPORTS LA English DT Article AB Objectives. Integration of surveillance for sexually transmitted diseases (STDs), human immunodeficiency virus (HIV), hepatitis, and tuberculosis (TB) may improve disease prevention and control. We determined the extent of surveillance integration in these programs, the benefits of integration, and barriers to increased integration. Methods. We e-mailed a survey to the 58 federally funded local and state STD control programs and followed up with phone interviews of nine program representatives. Results. The response rate was 81%. Many had compared infections by population subgroup for STDs and HIV (89%), STDs and hepatitis (53%), or STDs and TB (28%). Most (74%) had examined co-infections with HIV and STDs at the individual level and entered STD and HIV surveillance data into the same database (54%). All respondents thought some integration would be useful. Many (72%) used integrated data to disseminate information or change program strategies. The most commonly reported barriers to integration were policies preventing work with HIV data (85%) and incompatible databases (59%). Conclusions. Most STD control programs in the United States have some experience integrating surveillance data, but the degree of integration varies widely. Specific barriers to further integration were identified. The Centers for Disease Control and Prevention can help address these barriers by facilitating access to information and sharing technical solutions. Local and state programs can continue advancing surveillance integration by improving understanding of where integrated data are needed, increasing the use of available data, and pressing for appropriate and secure data sharing. C1 [Dowell, Deborah; Gaffga, Nicholas H.; Weinstock, Hillard; Peterman, Thomas A.] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Dowell, Deborah] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Dowell, D (reprint author), Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM ddowell@cdc.gov NR 22 TC 10 Z9 10 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 31 EP 38 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200006 PM 27382652 ER PT J AU Bissette, JM Stover, JA Newman, LM Delcher, PC Bernstein, KT Matthews, L AF Bissette, Jennifer M. Stover, Jeffrey A. Newman, Lori M. Delcher, Philip Christopher Bernstein, Kyle T. Matthews, Lindsey TI Assessment of Geographic Information Systems and Data Confidentiality Guidelines in STD Programs SO PUBLIC HEALTH REPORTS LA English DT Article ID EPIDEMIOLOGY AB Objective. Advancements in technology, such as geographic information systems (GIS), expand sexually transmitted disease (STD) program capacity for data analysis and visualization, and introduce additional confidentiality considerations. We developed a survey to examine GIS use among STD programs and to better understand existing data confidentiality practices. Methods. A Web-based survey of eight to 22 questions, depending on program-specific GIS capacity, was e-mailed to all STD program directors through the National Coalition of STD Directors in November 2004. Survey responses were accepted until April 15, 2005. Results. Eighty-five percent of the 65 currently funded STD programs responded to the survey. Of those, 58% used GIS and 54% used geocoding. STD programs that did not use GIS (42%) identified lack of training and insufficient staff as primary barriers. Mapping, spatial analyses, and targeting program interventions were the main reasons for geocoding data. Nineteen of the 25 programs that responded to questions related to statistical disclosure rules employed a numerator rule, and 56% of those used a variation of the "Rule of 5." Of the 28 programs that responded to questions pertaining to confidentiality guidelines, 82% addressed confidentiality of GIS data informally. Conclusions. Survey findings showed the increasing use of GIS and highlighted the struggles STD programs face in employing GIS and protecting confidentiality. Guidance related to data confidentiality and additional access to GIS software and training could assist programs in optimizing use of spatial data. C1 [Bissette, Jennifer M.; Stover, Jeffrey A.; Delcher, Philip Christopher; Matthews, Lindsey] Virginia Dept Hlth, Div Dis Prevent, Off Epidemiol, Richmond, VA 23219 USA. [Stover, Jeffrey A.] Virginia Commonwealth Univ, Dept Epidemiol & Community Hlth, Sch Med, Richmond, VA USA. [Newman, Lori M.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Delcher, Philip Christopher] Virginia Hlth Informat, Richmond, VA USA. [Bernstein, Kyle T.] San Francisco Dept Publ Hlth, San Francisco, CA USA. RP Bissette, JM (reprint author), Virginia Dept Hlth, Div Dis Prevent, Off Epidemiol, 109 Governor St, Richmond, VA 23219 USA. EM Jennifer.Bissette@vdh.virginia.gov NR 14 TC 3 Z9 3 U1 0 U2 2 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 58 EP 64 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200009 PM 27382655 ER PT J AU Rietmeijer, CA Donnelly, J Bernstein, KT Bissette, JM Martins, S Pathela, P Schillinger, JA Stenger, MR Weinstock, H Newman, LM AF Rietmeijer, Cornelis A. Donnelly, Jennifer Bernstein, Kyle T. Bissette, Jennifer M. Martins, Summer Pathela, Preeti Schillinger, Julia A. Stenger, Mark R. Weinstock, Hillard Newman, Lori M. TI Here Comes the SSuN: Early Experiences with the STD Surveillance Network SO PUBLIC HEALTH REPORTS LA English DT Article ID UNITED-STATES; GONOCOCCAL INFECTIONS; MEN; GONORRHEA; CHLAMYDIA; TRENDS; SEX AB In 2005, the Centers for Disease Control and Prevention established the STD Surveillance Network (SSuN), a sentinel surveillance system comprising local, enhanced sexually transmitted disease (STD) surveillance systems that follow common protocols. The purpose of SSuN is to improve the capacity of national, state, and local STD programs to detect, monitor, and respond rapidly to trends in STDs through enhanced collection, reporting, analysis, visualization, and interpretation of clinical, behavioral, and geographic information obtained from a geographically diverse sample of individuals diagnosed with STDs. To demonstrate the utility of a national sentinel surveillance network, this article reviews the lessons learned from the first three years of SSuN, which, through its enhanced gonorrhea and genital warts sentinel surveillance projects, has proved to be a useful adjunct to routine STD surveillance in the U.S. that can be expanded into other areas of STD public health interest. C1 [Rietmeijer, Cornelis A.] Denver Publ Hlth Dept, Denver, CO 80204 USA. [Rietmeijer, Cornelis A.] Univ Colorado, Sch Publ Hlth, Denver, CO 80202 USA. [Donnelly, Jennifer] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Bernstein, Kyle T.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Bissette, Jennifer M.] Virginia Dept Hlth, Richmond, VA USA. [Martins, Summer] Minnesota Dept Hlth, St Paul, MN USA. [Pathela, Preeti; Schillinger, Julia A.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schillinger, Julia A.; Weinstock, Hillard; Newman, Lori M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Stenger, Mark R.] Washington State Dept Hlth, Olympia, WA USA. RP Rietmeijer, CA (reprint author), Denver Publ Hlth Dept, 605 Bannock St, Denver, CO 80204 USA. EM krietmei@dhha.org NR 21 TC 11 Z9 11 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 BP 72 EP 77 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504II UT WOS:000270609200011 PM 27382657 ER PT J AU Hennessey, KA Bangsberg, DR Weinbaum, C Hahn, JA AF Hennessey, Karen A. Bangsberg, David R. Weinbaum, Cindy Hahn, Judith A. TI Hepatitis A Seroprevalence and Risk Factors Among Homeless Adults in San Francisco: Should Homelessness Be Included in the Risk-Based Strategy for Vaccination? SO PUBLIC HEALTH REPORTS LA English DT Article ID INJECTION-DRUG USERS; VIRAL-HEPATITIS; POPULATION; INFECTION; VIRUS; MEN; OUTBREAK AB Objectives. Homeless adults have an increased risk of infectious diseases due to sexual and drug-related behaviors and substandard living conditions. We investigated the prevalence and risk factors for presence of hepatitis A virus (HAV) antibodies among homeless and marginally housed adults. Methods. We analyzed serologic and questionnaire data from a study of marginally housed and homeless adults in San Francisco from April 1999 to March 2000. We tested seroprevalance for total antibodies to HAV (anti-HAV) and analyzed data using Chi-square tests and logistic regression. Results. Of the 1,138 adults in the study, 52% were anti-HAV positive. The anti-HAV prevalence in this study population was 58% higher than the expected prevalence based on age-specific prevalence rates from the general population. Number of years of homelessness (<= 1, 2-4, and; >= 5 years) was associated with anti-HAV prevalence (46%, 50%, and 61%, respectively, p<0.001). We found other differences in anti-HAV prevalence (p<0.05) for ever having injected drugs (63% vs. 42% for non-injectors), being foreign-born (75% vs. 51% among U.S.-born), race/ethnicity (72%, 53%, and 45% for Hispanic, white, and black people, respectively), and increasing age (38%, 49%, and 62% among those aged <35, 35-45, and >45 years, respectively). These variables all remained significant in a multivariate model. Conclusions. We found overall anti-HAV prevalence elevated in this San Francisco homeless population compared with the general U.S. population. These data show that anti-HAV was associated with homelessness independent of other known risk factors, such as being foreign-born, race/ethnicity, and injection drug use. This increase indicates an excess risk of HAV infection and the potential need to offer hepatitis A vaccination as part of homeless services. C1 [Hennessey, Karen A.; Weinbaum, Cindy] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Bangsberg, David R.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Harvard Initiat Global Hlth, Cambridge, MA 02138 USA. [Hahn, Judith A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Hennessey, KA (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd,E-05, Atlanta, GA 30333 USA. EM keh7@cdc.gov FU NIDA NIH HHS [K01 DA023365, K01 DA023365-03]; NIMH NIH HHS [R01 MH054907]; PHS HHS [K-24 015287, R01-1 54907] NR 18 TC 6 Z9 6 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 IS 6 BP 813 EP 817 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504IG UT WOS:000270608900008 PM 19894423 ER PT J AU Hanna, DB Pfeiffer, MR Sackoff, JE Selik, RM Begier, EM Torian, LV AF Hanna, David B. Pfeiffer, Melissa R. Sackoff, Judith E. Selik, Richard M. Begier, Elizabeth M. Torian, Lucia V. TI Comparing the National Death Index and the Social Security Administration's Death Master File to Ascertain Death in HIV Surveillance SO PUBLIC HEALTH REPORTS LA English DT Article ID RECORD LINKAGE; DATABASES; AIDS AB Objectives. New York City (NYC) maintains a population-based registry of people with human immunodeficiency virus (HIV) infection to monitor the epidemic and inform resource allocation. We evaluated record linkages with the National Death Index (NDI) and the Social Security Administration's Death Master File (SSDMF) to find deaths occurring from 2000 through 2004. Methods. We linked records from 32,837 people reported with HIV and not previously known to be dead with deaths reported in the NDI and the SSDMF. We calculated the kappa statistic to assess agreement between data sources. We performed subgroup analyses to assess differences within demographic and transmission risk subpopulations. We quantified the benefit of linkages with each data source beyond prior death ascertainment from local vital statistics data. Results. We discovered 1,926 (5.87%) deaths, which reduced the HIV prevalence estimate in NYC by 2.03%, from 1.19% to 1.16%. Of these, 458 (23.78%) were identified only from NDI, and 305 (15.84%) only from SSDMF. Agreement in ascertainment between sources was substantial (kappa = [K] 0.74, 95% confidence interval [CI] 0.72, 0.76); agreement was lower among Hispanic people (K=0.65, 95% Cl 0.62, 0.69) and people born outside the U.S. (K=0.60, 95% Cl 0.52, 0.68). We identified an additional 13.62% of deaths to people reported with HIV in NYC; white people and men who have sex with men were disproportionately likely to be underascertained without these linkages (p<0.0001). Conclusion. Record linkages with national databases are essential for accurate prevalence estimates from disease registries, and the SSDMF is an inexpensive means to supplement linkages with the NDI to maximize death ascertainment. C1 [Hanna, David B.; Pfeiffer, Melissa R.; Sackoff, Judith E.; Begier, Elizabeth M.; Torian, Lucia V.] New York City Dept Hlth & Mental Hyg, HIV Epidemiol & Field Serv Program, Bur HIV AIDS Prevent & Control, New York, NY USA. [Selik, Richard M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Hanna, DB (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St,POB 130, Baltimore, MD 21205 USA. EM dhanna@jhsph.edu FU New York City Department of Health; Centers for Disease Control and Prevention (CDC) [U62/CCU223595] FX This work was supported by a cooperative agreement between the New York City Department of Health and Mental Hygiene and the Centers for Disease Control and Prevention (CDC) (U62/CCU223595). NR 29 TC 12 Z9 12 U1 0 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 IS 6 BP 850 EP 860 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504IG UT WOS:000270608900013 PM 19894428 ER PT J AU Beavers, SF Blossom, DB Wiemken, TL Kawaoka, KY Wong, A Goss, L McCormick, MI Thoroughman, D Srinivasan, A AF Beavers, Suzanne F. Blossom, David B. Wiemken, Timothy L. Kawaoka, Kelly Y. Wong, Andrew Goss, Linda McCormick, Malkanthie I. Thoroughman, Douclas Srinivasan, Arjun TI Comparison of Risk Factors for Recovery of Acinetobacter baumannii During Outbreaks at Two Kentucky Hospitals, 2006 SO PUBLIC HEALTH REPORTS LA English DT Article ID INTENSIVE-CARE-UNIT; VENTILATOR-ASSOCIATED PNEUMONIA; ENVIRONMENTAL CONTAMINATION; INFECTIONS; EPIDEMIOLOGY; BACTEREMIA AB Objectives. Acinetobacter baumannii (A. baumannii) is a well-described cause of nosocomial outbreaks and can be highly resistant to antimicrobials. We investigated A. baumannii outbreaks at two Kentucky hospitals to find risk factors for Acinetobacter acquisition in hospitalized patients. Methods. We performed case-control studies at both hospitals. We defined a case as a clinical culture growing A. baumannii from a patient from August 1 to October 31, 2006 (Hospital A), or April 1 to October 31, 2006 (Hospital B). Results. Twenty-nine cases were identified at Hospital A and 72 cases were identified at Hospital B. The median case patient age was 42 years in Hospital A and 46 years in Hospital B. The majority of positive cultures were from sputum (Hospital A, 51.7%; Hospital B, 62.5%). The majority of case patients had multidrug-resistant A. baumannii (Hospital A, 75.9%; Hospital B, 70.8%). Using logistic regression, controlling for age and admitting location, mechanical ventilation (Hospital A odds ratio [OR] = 21.6; 95% confidence interval [0] 3.5, 265.9; Hospital B OR=4.5, 95% Cl 1.9, 11.1) was associated with A. baumannii recovery. Presence of a nonsurgical wound (OR=6.6, 95% Cl 1.2, 50.8) was associated with recovery of A. baumannii at Hospital A. Conclusions. We identified similar patient characteristics and risk factors for A. baumannii acquisition at both hospitals. Our findings necessitate the importance of review of infection control procedures related to respiratory therapy and wound care. C1 [Beavers, Suzanne F.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div TB Eliminat, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Beavers, Suzanne F.; Thoroughman, Douclas] Kentucky Dept Publ Hlth, Frankfort, KY USA. [Beavers, Suzanne F.; Blossom, David B.; Kawaoka, Kelly Y.; Wong, Andrew] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Wiemken, Timothy L.; Goss, Linda] Univ Louisville Healthcare, Louisville, KY USA. [McCormick, Malkanthie I.] Univ Kentucky, Coll Med, Lexington, KY USA. [Thoroughman, Douclas] Ctr Dis Control & Prevent, Coordinating Off Terrorism Preparedness & Emergen, Atlanta, GA 30333 USA. [Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Beavers, SF (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div TB Eliminat, Epidem Intelligence Serv, MS E-10,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM SBeavers@cdc.gov FU CDC FX This study was funded by CDC Epi-Aid 2007-11. NR 23 TC 6 Z9 7 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 IS 6 BP 868 EP 874 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504IG UT WOS:000270608900015 PM 19894430 ER PT J AU Orians, C Rose, S Hubbard, B Sarisky, J Reason, L Bernichon, T Liebow, E Skarpness, B Buchanan, S AF Orians, Carlyn Rose, Shyanika Hubbard, Brian Sarisky, John Reason, Letitia Bernichon, Tiffiny Liebow, Edward Skarpness, Bradley Buchanan, Sharunda TI Strengthening the Capacity of Local Health Agencies Through Community-Based Assessment and Planning SO PUBLIC HEALTH REPORTS LA English DT Article AB Objectives. We evaluated the effectiveness of the Protocol for Assessing Community Excellence in Environmental Health (PACE EH) in building competency in essential environmental health services and renewing efforts to engage the community in problem solving. Competency and community engagement have been identified by environmental health practitioners as important to meet new threats to public health. Methods. We conducted a national survey and 24 case studies of public health agencies. We invited 917 organizations to participate in the national survey because they had requested a copy of the protocol. Results. We received 656 total responses: 354 had not considered implementation, 302 had considered implementation, and 66 had implemented PACE EH. For the 24 case studies, we interviewed 206 individuals in communities implementing PACE EH. We found that PACE EH has had a positive effect on building community and professional networks, enhancing leadership, developing workforce competence, and expanding definitions of environmental health practice. Conclusions. With appropriate investments, PACE EH can be an effective tool to meet the environmental health challenges identified by local environmental health practitioners and state, tribal, and federal agencies. C1 [Orians, Carlyn; Reason, Letitia; Liebow, Edward] Battelle Ctr Publ Hlth Res & Evaluat, Seattle, WA 98109 USA. [Rose, Shyanika] Battelle Ctr Publ Hlth Res & Evaluat, Durham, NC USA. [Buchanan, Sharunda] Ctr Dis Control & Prevent, Div Emergency Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA USA. [Bernichon, Tiffiny] Battelle Ctr Publ Hlth Res & Evaluat, Arlington, VA USA. [Skarpness, Bradley] Battelle Ctr Publ Hlth Res & Evaluat, Atlanta, GA USA. RP Orians, C (reprint author), Battelle Ctr Publ Hlth Res & Evaluat, 1100 Dexter Ave N,Ste 400, Seattle, WA 98109 USA. EM orians@battelle.org NR 26 TC 2 Z9 2 U1 1 U2 2 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 2009 VL 124 IS 6 BP 875 EP 882 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 504IG UT WOS:000270608900016 PM 19894431 ER PT J AU Kiene, SM Bateganya, M Wanyenze, R Lule, H Mayer, K Stein, M AF Kiene, Susan M. Bateganya, Moses Wanyenze, Rhoda Lule, Haruna Mayer, Kenneth Stein, Michael TI Provider-initiated HIV testing in health care settings: Should it include client-centered counselling? SO SAHARA J-JOURNAL OF SOCIAL ASPECTS OF HIV-AIDS LA English DT Article DE Provider-initiated HIV testing; client-centered counselling; HIV prevention; developing countries ID UNPROTECTED SEXUAL-BEHAVIOR; INFECTED PATIENTS; SOUTH-AFRICA; UGANDA; INTERVENTION; METAANALYSIS; BOTSWANA; KAMPALA; WOMEN AB To increase access to HIV testing, the WHO and CDC have recommended implementing provider-initiated HIV testing (PITC). To address the resource limitations of the PITC setting, WHO and CDC suggest that patient-provider interactions during PITC may need to focus on providing information and referrals, instead of engaging patients in client-centered counselling, as is recommended during client-initiated HIV testing. Providing HIV prevention information has been shown to be less effective than client-centered counselling in reducing HIV-risk behaviour and STI incidence. Therefore, concerns exist about the efficacy of PITC as an HIV prevention approach. However, reductions in HIV incidence may be greater if more people know their HIV status through expanded availability of PITC, even if PITC is a less effective prevention intervention than is client-initiated HIV testing for individual patients. In the absence of an answer to this public health question, adaptation of effective brief client-centered counselling approaches to PITC should be explored along with research assessing the efficacy of PITC. C1 [Mayer, Kenneth] Brown Univ, AIDS Int Training & Res Programme, Providence, RI 02912 USA. [Stein, Michael] Rhode Isl Hosp, HIV Serv, Providence, RI 02903 USA. [Kiene, Susan M.; Wanyenze, Rhoda] Makerere Univ, Sch Publ Hlth, CDC HIV Fellowship Programme, Kampala, Uganda. [Mayer, Kenneth] Miriam Hosp Rhode Isl, Providence, RI USA. [Mayer, Kenneth] Ctr Dis Control, Atlanta, GA 30333 USA. [Mayer, Kenneth] NIH, New England Vaccine Preparedness Cohort Studies, Bethesda, MD USA. [Mayer, Kenneth] Natl Inst Hlth, Data Safety & Monitoring Board, AIDS Clin Trials Grp, Bethesda, MD 20892 USA. RP Kiene, SM (reprint author), Makerere Univ, Sch Publ Hlth, CDC HIV Fellowship Programme, Kampala, Uganda. EM susan_kiene@brown.edu FU NIDA NIH HHS [K24 DA00512]; NIMH NIH HHS [K01 MH083536] NR 27 TC 6 Z9 6 U1 4 U2 4 PU SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP PI CLAREMONT PA 21 DREYER ST, 4TH FLOOR, SANCLARE BLDG, CLAREMONT, 7700, SOUTH AFRICA SN 1729-0376 J9 SAHARA J-J SOC ASP H JI Sahara J-J. Soc. Asp. HIV/AIDS PD NOV PY 2009 VL 6 IS 3 BP 115 EP 119 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 534PR UT WOS:000272910100003 PM 20485851 ER PT J AU Dunne, EF Nielson, CM Hagensee, ME Papenfuss, MR Harris, RB Herrel, N Gourlie, J Abrahamsen, M Markowitz, LE Giuliano, AR AF Dunne, Eileen F. Nielson, Carrie M. Hagensee, Michael E. Papenfuss, Mary R. Harris, Robin B. Herrel, Nicholas Gourlie, Jennifer Abrahamsen, Martha Markowitz, Lauri E. Giuliano, Anna R. TI HPV 6/11, 16, 18 Seroprevalence in Men in Two US Cities SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID HUMAN-PAPILLOMAVIRUS; UNITED-STATES; CERVICAL-CANCER; INFECTION; PREVALENCE; TYPE-16; WOMEN; SEROEPIDEMIOLOGY; ANTIBODIES AB Background: A vaccine to prevent human papillomavirus (HPV) 6, HPV 11, HPV 16, or HPV 18 and associated diseases is licensed for females, and it may be licensed for men in the future. There are limited data on HPV 6/11, 16, and/or 18 seroprevalence in men. Methods: A total of 490 men aged 18 to 40 years were enrolled in a study of HPV in men in Tucson, AZ, and Tampa, FL. Enrolled men completed a self-administered questionnaire, and HPV serology was performed using HPV 6/11, 16, and 18 VLP assays. Results: Overall, seroprevalence to HPV 16 was 12.1%, HPV 6/11 was 9.7%, and to HPV 18 was 5.4%. Seroprevalence to HPV 6/11, 16, and/or 18 was 21% and was highest among 35 to 40 year olds (48%); prevalence in this age group was significantly higher compared to the 18 to 24 year olds (adjusted odds ratio (aOR) 6.8, 95% confidence interval (CI) 3.7, 12.8). Independent predictors of seropositivity to HPV 6/11, 16, and/or 18 were older age, greater number of female sex partners in the past 3 months, and current smoking. Conclusions: HPV vaccine-type seroprevalence was highest in 35 to 40 year old men. These data on the epidemiology of HPV seroprevalence in men are useful for discussions regarding recommendations for HPV vaccine if licensed for use in men. C1 [Dunne, Eileen F.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Nielson, Carrie M.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Nielson, Carrie M.; Harris, Robin B.] Univ Arizona, Ctr Canc, Tucson, AZ USA. [Nielson, Carrie M.; Harris, Robin B.] Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA. [Hagensee, Michael E.; Herrel, Nicholas; Gourlie, Jennifer] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. [Papenfuss, Mary R.; Abrahamsen, Martha; Giuliano, Anna R.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. RP Dunne, EF (reprint author), 1600 Clifton Rd,MS E-02, Atlanta, GA 30030 USA. EM dde9@cdc.gov FU Centers for Disease Control and Prevention through the Association of American Medical Colleges [U36/CCU319276, MM-0579-03/03] FX Supported by the Centers for Disease Control and Prevention through the Association of American Medical Colleges, grants U36/CCU319276, AAMC ID number MM-0579-03/03. Publication and report contents are solely the responsibility of the authors and do not necessarily represent the official views of the AAMC or the CDC. NR 17 TC 17 Z9 17 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD NOV PY 2009 VL 36 IS 11 BP 671 EP 674 DI 10.1097/OLQ.0b013e3181bc094b PG 4 WC Infectious Diseases SC Infectious Diseases GA 511OA UT WOS:000271173900001 PM 19809385 ER PT J AU Douglas, JM Berman, SM AF Douglas, John M., Jr. Berman, Stuart M. TI Screening for HSV-2 Infection in STD Clinics and Beyond: A Few Answers But More Questions SO SEXUALLY TRANSMITTED DISEASES LA English DT Editorial Material ID SIMPLEX-VIRUS TYPE-2; FOCUS ELISA TESTS; GENITAL HERPES; DAILY VALACYCLOVIR; PUBLIC-HEALTH; ACQUISITION; ANTIBODIES; WOMEN; HERPES-SIMPLEX-VIRUS-2; ASSAY C1 [Douglas, John M., Jr.; Berman, Stuart M.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30333 USA. RP Douglas, JM (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Div Sexually Transmitted Dis Prevent, 1600 Clifton Rd,Mail Stop E-02, Atlanta, GA 30333 USA. EM jyd3@cdc.gov NR 33 TC 9 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD NOV PY 2009 VL 36 IS 11 BP 729 EP 731 DI 10.1097/OLQ.0b013e3181c04dea PG 3 WC Infectious Diseases SC Infectious Diseases GA 511OA UT WOS:000271173900012 PM 19809383 ER PT J AU Akksilp, S Wattanaamornkiat, W Kittikraisak, W Nateniyom, S Rienthong, S Sirinak, C Ngamlert, K Mankatittham, W Sattayawuthipong, W Sumnapun, S Yamada, N Monkongdee, P Anuwatnonthakate, A Burapat, C Wells, CD Tappero, JW Varma, JK AF Akksilp, Somsak Wattanaamornkiat, Wanpen Kittikraisak, Wanitchaya Nateniyom, Sriprapa Rienthong, Somsak Sirinak, Chawin Ngamlert, Keerataya Mankatittham, Wiroj Sattayawuthipong, Wanchai Sumnapun, Surin Yamada, Norio Monkongdee, Patama Anuwatnonthakate, Amornrat Burapat, Channawong Wells, Charles D. Tappero, Jordan W. Varma, Jay K. TI MULTI-DRUG RESISTANT TB AND HIV IN THAILAND: OVERLAPPING, BUT NOT INDEPENDENTLY ASSOCIATED RISK FACTORS SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article ID HEALTH-CARE; DRUG-USERS; TUBERCULOSIS; BANGKOK; PERFORMANCE; MANAGEMENT; INFECTION; IMPACT; PRISON; SIDE AB The HIV and multi-drug resistant tuberculosis (MDR-TB) epidemics are closely linked. In Thailand as part of a sentinel surveillance system, we collected data prospectively about pulmonary TB cases treated in public clinics. A subset of HIV-infected TB patients identified through this system had additional data collected for a research study. We conducted multivariate analysis to identify factors associated with MDR-TB. Of 10,428 TB patients, 2,376 (23%) were HIV-infected; 145 had MDR-TB. Of the MDR-TB cases, 52 (37%) were HIV-infected. Independent risk factors for MDR-TB included age 18-29 years old, male sex, and previous TB treatment, but not HIV infection. Among now patients, having an injection drug use history was a risk factor for MDR-TB. Of 539 HIV-infected TB patients in the research Study, MDR-TB was diagnosed. in 19 (4%); the only significant risk factors were previous TB treatment and previous hepatitis. In Thailand, HIV is common among MDR-TB patients, but is not an independent risk factor for MDR-TB Populations at high risk for HIV-young adults, men, injection drug users - should be prioritized for drug susceptibility testing. C1 [Akksilp, Somsak; Wattanaamornkiat, Wanpen] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Kittikraisak, Wanitchaya; Monkongdee, Patama; Anuwatnonthakate, Amornrat; Burapat, Channawong; Varma, Jay K.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Sirinak, Chawin; Ngamlert, Keerataya] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand. [Mankatittham, Wiroj] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Sattayawuthipong, Wanchai] Phuket Prov Hlth Off, Phuket, Thailand. [Sumnapun, Surin] Chiang Rai Prov Hlth Off, Chiang Rai, Thailand. [Yamada, Norio] Res Inst TB, Tokyo, Japan. [Wells, Charles D.; Tappero, Jordan W.; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Varma, JK (reprint author), CDC, US Embassy Beijing, 55 An Jia Lou Rd, Beijing 100600, Peoples R China. EM jvarma@cdc.gov FU US Agency for International Development FX We thank the US Agency for International Development for funding this study. The funding agency had no role in the study design, conduct, data analysis, Or manuscript preparation. None of the authors have a commercial or other financial interest associated with the information presented in this manuscript. NR 31 TC 2 Z9 3 U1 0 U2 3 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2009 VL 40 IS 6 BP 1264 EP 1278 PG 15 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 530GV UT WOS:000272578200015 PM 20578461 ER PT J AU Burapat, C Kittikraisak, W Cain, KP Tasaneeyapan, T Nateniyom, S Akksilp, S Mankatittham, W Sirinak, C Sattayawuthipong, W Varma, JK AF Burapat, Channawong Kittikraisak, Wanitchaya Cain, Kevin P. Tasaneeyapan, Theerawit Nateniyom, Sriprapa Akksilp, Somsak Mankatittham, Wiroj Sirinak, Chawin Sattayawuthipong, Wanchai Varma, Jay K. TI HEALTH-SEEKING BEHAVIOR AMONG HIV-INFECTED PATIENTS TREATED FOR TB IN THAILAND SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article ID PUBLIC-HEALTH; TUBERCULOSIS; HIV/AIDS; AFRICA; STIGMA; IMPACT AB In Asia, patients increasingly seek tuberculosis (TB) treatment in the private sector; however, few private sector practices follow international TB management guidelines We conducted a study to measure the frequency and predictors of seeking TB diagnosis in the private sector among 756 HIV-infected TB patients in four Thai provinces during 2005-2006. Of enrolled patients, 97 (13%) first sought care at a private. provider and 83 (11%) at a pharmacy. In multivariable analysis, the only factor independently associated with seeking care at a private provider was having a high TB stigma score. Factors independently associated with seeking care at a pharmacy included not knowing that TB call be cured and that TB care call be provided close to home. Patients reported that the Most Influential factor in choosing a provider was confidentiality (468, 62%). Further research is needed to evaluate whether educating the community about the confidentiality, availability, and success of curing TB at government health facilities can promote prompt utilization of public TB treatment services by HIV-infected patients in Thailand. C1 [Burapat, Channawong; Kittikraisak, Wanitchaya; Tasaneeyapan, Theerawit; Varma, Jay K.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Cain, Kevin P.; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Akksilp, Somsak] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Mankatittham, Wiroj] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Sirinak, Chawin] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand. [Sattayawuthipong, Wanchai] Prov Hlth Off, Phuket, Thailand. RP Varma, JK (reprint author), CDC Sect, US Embassy Beijing, 55 An Jia Lou Rd, Beijing 100600, Peoples R China. FU US Agency for International Development FX We thank the US Agency for International Development for funding this project and Dr Christine Hansen for her help ill designing the questionnaire Used to assess health-seeking behavior. This project was funded by the US Agency for International Development. The funding agency had no role in study design, conduct, data analysis, or manuscript preparation None of the authors has I commercial or other financial Interest associated with the information presented in this manuscript. NR 29 TC 1 Z9 1 U1 0 U2 0 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2009 VL 40 IS 6 BP 1335 EP 1346 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 530GV UT WOS:000272578200024 PM 20578470 ER PT J AU Akksilp, S Wattanaamornkiat, W Kittikraisak, W Nateniyom, S Rienthong, S Sirinak, C Ngamlert, K Mankatittham, W Sattayawuthipong, W Sumnapun, S Yamada, N Monkongdee, P Anuwatnonthakate, A Burapat, C De Wells, C Tappero, JW Varma, JK AF Akksilp, Somsak Wattanaamornkiat, Wanpen Kittikraisak, Wanitchava Nateniyom, Sriprapa Rienthong, Somsak Sirinak, Chawin Ngamlert, Keerataya Mankatittham, Wiroj Sattayawuthipong, Wanchai Sumnapun, Surin Yamada, Norio Monkongdee, Patama Anuwatnonthakate, Amornrat Burapat, Channawong De Wells, Charles Tappero, Jordan W. Varma, Jay K. TI MULTT-DRUG RESISTANT TB AND HIV IN THAILAND: OVERLAPPING, BUT NOT INDEPENDENTLY ASSOCIATED RISK FACTORS (vol 40, pg 1264, 2009) SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Correction C1 [Akksilp, Somsak; Wattanaamornkiat, Wanpen] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Kittikraisak, Wanitchava; Monkongdee, Patama; Anuwatnonthakate, Amornrat; Burapat, Channawong; Varma, Jay K.] Thailand Minist Publ Hlth US CDC Collaborat, Nonthaburi, Thailand. [Sirinak, Chawin; Ngamlert, Keerataya] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand. [Mankatittham, Wiroj] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Sattayawuthipong, Wanchai] Phuket Prov Hlth Off, Phuket, Thailand. [Sumnapun, Surin] Chiang Rai Prov Hlth Off, Chiang Rai, Thailand. [Yamada, Norio] Res Inst TB, Tokyo, Japan. [De Wells, Charles; Tappero, Jordan W.; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Nateniyom, Sriprapa; Rienthong, Somsak] Thailand Minist Publ Hlth, Nonthaburi, Thailand. RP Akksilp, S (reprint author), Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2009 VL 40 IS 6 BP 1395 EP 1395 PG 1 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 530GV UT WOS:000272578200029 ER PT J AU Amnuaiphon, W Anuwatnonthakate, A Nuyongphak, P Sinthuwatanawibool, C Rujiwongsakorn, S Nakara, P Komsakorn, S Wattanaamornkiet, W Moolphate, S Chiengsorn, N Kaewsaard, S Nateniyom, S Varma, JK AF Amnuaiphon, Waraya Anuwatnonthakate, Amornrat Nuyongphak, Prungsri Sinthuwatanawibool, Chalinthorn Rujiwongsakorn, Sadudee Nakara, Prapa Komsakorn, Sitijate Wattanaamornkiet, Wanpen Moolphate, Saiyud Chiengsorn, Navarat Kaewsaard, Samroui Nateniyom, Sriprapa Varma, Jay K. TI Factors associated with death among HIV-uninfected TB patients in Thailand, 2004-2006 SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE tuberculosis; HIV-uninfected; Thailand; death ID TUBERCULOSIS-RELATED DEATHS; ANTIRETROVIRAL THERAPY; RISK-FACTORS; PULMONARY TUBERCULOSIS; INFECTED PATIENTS; RESISTANT TUBERCULOSIS; MORTALITY; SURVIVAL; IMPACT; EPIDEMIOLOGY AB OBJECTIVES In countries with both TB and human immunodeficiency virus (HIV) epidemics, HIV is known to be the most powerful risk factor for death during tuberculosis (TB) treatment. Few recent studies have evaluated risk factors for death among HIV-uninfected TB patients in these countries. We analysed data from a multi-province demonstration project in Thailand to answer this question. METHOD We prospectively collected data from HIV-uninfected TB patients treated for TB in four provinces and the national infectious diseases hospital in Thailand from 2004-2006. Standard WHO definitions were used to classify treatment outcomes. We used log-binomial multivariate regression to calculate adjusted relative risk (aRR) and 95% confidence intervals (CI) for factors associated with death. RESULTS Of 5318 cases, 441 (8%) died during TB treatment. The mean age was 47 years (range 8 months-97 years). Multidrug-resistant (MDR)-TB was diagnosed in 62 (1%). In multivariate analysis, patients older than 44 years were significantly more likely to die than patients aged 15-44 years [age 45 64, aRR 2.9 (CI 2.2 -3.8)] [age > 64 years, aRR 5.0 (CI 3.9-6.6)]. Other independent risk factors for death included Thai nationality [aRR 3.9 (CI 1.6-9.5)], MDR-TB [aRR 2.8 (CI 1.7-4.8)], not being married [aRR 1.4 (CI 1.2-1.7)], and living in Chiang Rai province [aRR 2.7 (CI 1.7-4.4)]. CONCLUSIONS The death rate was high among HIV-uninfected TB patients in Thailand. Efforts to improve TB diagnosis and treatment in the elderly and to improve MDR-TB treatment may help reduce mortality. C1 [Amnuaiphon, Waraya] Vachira Phuket Hosp, Phuket, Thailand. [Anuwatnonthakate, Amornrat; Sinthuwatanawibool, Chalinthorn; Varma, Jay K.] US CDC Collaborat, Thailand MOPH, Nonthaburi, Thailand. [Nuyongphak, Prungsri] Thalang Hosp, Phuket, Thailand. [Rujiwongsakorn, Sadudee; Nakara, Prapa] Phuket Prov Publ Hlth Off, Phuket, Thailand. [Komsakorn, Sitijate] Chiang Rai Prov Publ Hlth Off, Chiang Rai, Thailand. [Wattanaamornkiet, Wanpen] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Moolphate, Saiyud] Res Inst TB, Tokyo, Japan. [Chiengsorn, Navarat] Bangkok Metropolitan Hlth Adm, Bangkok, Thailand. [Kaewsaard, Samroui] Bamrasnaradura Inst, Nonthaburi, Thailand. [Nateniyom, Sriprapa] Thailand Minist Publ Hlth, Ban, Thailand. [Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Varma, JK (reprint author), CDC, US Embassy Beijing, 3 Xiu Shui Bei Jie, Beijing 100600, Peoples R China. EM jvarma@cdc.gov FU USCDC; US Agency for International Development (USAID) FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of USCDC. NR 43 TC 5 Z9 5 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD NOV PY 2009 VL 14 IS 11 BP 1338 EP 1346 DI 10.1111/j.1365-3156.2009.02376.x PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 505XI UT WOS:000270734300004 PM 19735372 ER PT J AU Touch, S Hills, S Sokhal, B Samnang, C Sovann, L Khieu, V Soeung, SC Toda, K Robinson, J Grundy, J AF Touch, Sok Hills, Susan Sokhal, Buth Samnang, Chham Sovann, Ly Khieu, Virak Soeung, Sann Chan Toda, Kohei Robinson, Jaimie Grundy, John TI Epidemiology and burden of disease from Japanese encephalitis in Cambodia: results from two years of sentinel surveillance SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Japanese encephalitis; arboviruses; epidemiology ID DIAGNOSIS; CHILDREN; INFECTIONS; VIRUS; SERUM AB OBJECTIVES To describe the results from two years of Japanese encephalitis (JE) sentinel surveillance in Cambodia. METHODS Sentinel site surveillance for JE in children aged 15 years and under was implemented in Cambodia in mid-2006. It was integrated into the routine meningoencephalitis surveillance system. Six hospitals were selected as sentinel sites. Epidemiological information and diagnostic specimens were collected from each patient presenting with meningoencephalitis. Cerebrospinal fluid and sera were tested for presence of immunoglobulin M antibodies against JE and dengue viruses by an ELISA. Surveillance data from 2006 to 2008 were analysed. RESULTS Of 586 patients presenting with meningoencephalitis, 110 (19%) were confirmed to have JE. The percentage of confirmed JE cases at individual sentinel sites ranged from 13% to 35% of all meningoencephalitis cases. Mean age was 6.2 years, with 95% of JE cases in children aged 12 years and under. Cases occurred year-round in both 12-month reporting periods. CONCLUSIONS JE is an important cause of meningoencephalitis in Cambodian children. As JE is a vaccine-preventable disease, an immunization programme could result in a considerable reduction in morbidity and mortality from JE among children in Cambodia. C1 [Hills, Susan; Robinson, Jaimie] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80526 USA. [Touch, Sok; Sovann, Ly] Minist Hlth, Dept Communicable Dis Control, Phnom Penh, Cambodia. [Hills, Susan] PATH, Seattle, WA USA. [Sokhal, Buth] Minist Hlth, Natl Inst Publ Hlth, Phnom Penh, Cambodia. [Samnang, Chham] PATH, Phnom Penh, Cambodia. [Khieu, Virak] Inst Pasteur Cambodge, Phnom Penh, Cambodia. [Soeung, Sann Chan] Minist Hlth, Natl Immunizat Program, Phnom Penh, Cambodia. [Toda, Kohei] World Hlth Org, Phnom Penh, Cambodia. [Grundy, John] Univ Melbourne, Nossal Inst Global Hlth, Melbourne, Vic, Australia. RP Hills, S (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80526 USA. EM shills@cdc.gov FU Institut Pasteur's grant [ACIP A/10/2004] FX The surveillance work was funded, in part, through Institut Pasteur's grant ACIP#A/10/2004. Support for testing specimens at the US CDC Department of Health and Human Services was provided by the Acute Meningitis-Encephalitis Syndrome Surveillance project of US CDC's Global Disease Detection and Response Initiative. NR 32 TC 9 Z9 9 U1 1 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD NOV PY 2009 VL 14 IS 11 BP 1365 EP 1373 DI 10.1111/j.1365-3156.2009.02380.x PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 505XI UT WOS:000270734300008 PM 19747185 ER PT J AU Armour, BS Thierry, JM Wolf, LA AF Armour, Brian S. Thierry, JoAnn M. Wolf, Lesley A. TI STATE-LEVEL DIFFERENCES IN BREAST AND CERVICAL CANCER SCREENING BY DISABILITY STATUS United States, 2008 SO WOMENS HEALTH ISSUES LA English DT Article ID PREVENTIVE SERVICES; PHYSICAL-DISABILITIES; HEALTH-CARE; WOMEN; QUALITY; RECEIPT; ACCESS AB Introduction and Background. Despite reported disparities in the use of preventive services by disability status, there has been no national surveillance of breast and cervical cancer screening among women with disabilities in the United States. To address this, we used state-level surveillance data to identify disparities in breast and cervical cancer screening among women by disability status. Methods. Data from the 2008 Behavioral Risk Factor Surveillance System were used to estimate disability prevalence and state-level differences in breast and cervical cancer screening among women by disability status. Results. Overall, modest differences in breast cancer screening were found; women with a disability were less likely than those without to report receiving a mammogram during the past 2 years (72.2% vs. 77.8%; p < .001). However, disparities in breast cancer screening were more pronounced at the state level. Furthermore, women with a disability were less likely than those without a disability to report receiving a Pap test during the past 3 years (78.9% vs. 83.4%; p < .001). Discussion. This epidemiologic evidence identifies an opportunity for federal and state programs, as well as other stakeholders, to form partnerships to align disability and women's health policies. Furthermore, it identifies the need for increased public awareness and resource allocation to reduce barriers to breast and cervical cancer screening experienced by women with disabilities. C1 [Armour, Brian S.; Thierry, JoAnn M.] Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Wolf, Lesley A.] Sci Applicat Int Corp, Atlanta, GA USA. RP Armour, BS (reprint author), 1600 Clifton Rd NE,Mail Stop E-88, Atlanta, GA 30333 USA. EM barmour@cdc.gov NR 43 TC 35 Z9 35 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD NOV-DEC PY 2009 VL 19 IS 6 BP 406 EP 414 DI 10.1016/j.whi.2009.08.006 PG 9 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA 518SG UT WOS:000271712900008 PM 19879454 ER PT J AU Deak, E Wilson, SD White, E Carr, JH Balajee, SA AF Deak, Eszter Wilson, Selwyn D. White, Elizabeth Carr, Janice H. Balajee, S. Arunmozhi TI Aspergillus terreus Accessory Conidia Are Unique in Surface Architecture, Cell Wall Composition and Germination Kinetics SO PLOS ONE LA English DT Article ID AMPHOTERICIN-B; CANDIDA-ALBICANS; PULMONARY ASPERGILLOSIS; ERGOSTEROL CONTENT; MURINE MODEL; FUMIGATUS; SUSCEPTIBILITY; INFECTIONS; BIOSYNTHESIS; QUANTITATION AB Infection with Aspergillus terreus is more likely to result in invasive, disseminated disease when compared to other Aspergillus species; importantly this species appears to be less susceptible to the antifungal drug amphotericin B. Unique to this species is the ability to produce specialized structures denoted as accessory conidia (AC) directly on hyphae both in vitro and in vivo. With the hypothesis that production of AC by A. terreus may enhance virulence of this organism, we analyzed the phenotype, structure and metabolic potential of these conidia. Comparison of A. terreus phialidic conidia (conidia that arise from conidiophores, PC) and AC architecture by electron microscopy revealed distinct morphological differences between the two conidial forms; AC have a smoother, thicker outer cell surface with no apparent pigment-like layer. Further, AC germinated rapidly, had enhanced adherence to microspheres, and were metabolically more active compared to PC. Additionally, AC contained less cell membrane ergosterol, which correlated with decreased susceptibility to AMB as determined using a flow cytometry based analysis. Furthermore, AC exhibited surface patches of beta 1-3 glucan, suggestive of attachment scarring. Collectively, the findings of this study suggest a possible role for AC in A. terreus pathogenesis. RP Deak, E (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. EM fir3@cdc.gov NR 26 TC 14 Z9 14 U1 2 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 30 PY 2009 VL 4 IS 10 AR e7673 DI 10.1371/journal.pone.0007673 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 514RW UT WOS:000271414300017 PM 19888344 ER PT J AU Walke, HT Simone, PM AF Walke, H. T. Simone, P. M. TI BUILDING CAPACITY IN FIELD EPIDEMIOLOGY: LESSONS LEARNED FROM THE EXPERIENCE IN EUROPE SO EUROSURVEILLANCE LA English DT Editorial Material ID HEALTH; PROGRAMS; SERVICE C1 [Walke, H. T.; Simone, P. M.] Ctr Dis Control & Prevent, Div Global Publ Hlth Capac Dev, Coordinating Off Global Hlth, Atlanta, GA 30333 USA. RP Walke, HT (reprint author), Ctr Dis Control & Prevent, Div Global Publ Hlth Capac Dev, Coordinating Off Global Hlth, Atlanta, GA 30333 USA. EM hfw3@cdc.gov NR 12 TC 0 Z9 0 U1 0 U2 0 PU EUR CENTRE DIS PREVENTION & CONTROL PI STOCKHOLM PA TOMTEBODAVAGEN 11A, STOCKHOLM, 171 83, SWEDEN SN 1560-7917 J9 EUROSURVEILLANCE JI Eurosurveillance PD OCT 29 PY 2009 VL 14 IS 43 BP 2 EP 3 AR 19376 PG 2 WC Infectious Diseases SC Infectious Diseases GA 515IR UT WOS:000271463900001 ER PT J AU Glass, RI Parashar, UD Estes, MK AF Glass, Roger I. Parashar, Umesh D. Estes, Mary K. TI CURRENT CONCEPTS Norovirus Gastroenteritis SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review ID NORWALK VIRUS-INFECTION; BLOOD GROUP ANTIGENS; REVERSE TRANSCRIPTION-PCR; HUMAN CALICIVIRUS; IMMUNE-RESPONSES; SPORADIC GASTROENTERITIS; VIRAL GASTROENTERITIS; UNITED-STATES; FECAL SAMPLES; CHILDREN C1 [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Glass, Roger I.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Estes, Mary K.] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA. RP Glass, RI (reprint author), NIH, Fogarty Int Ctr, 31 Ctr Dr,Rm 31 B2 C02, Bethesda, MD 20892 USA. FU National Institutes of Health FX Supported by grants from the National Institutes of Health (to Dr. Estes). NR 67 TC 460 Z9 478 U1 15 U2 133 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 29 PY 2009 VL 361 IS 18 BP 1776 EP 1785 DI 10.1056/NEJMra0804575 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 511RY UT WOS:000271185600010 PM 19864676 ER PT J AU Emerson, GL Li, Y Frace, MA Olsen-Rasmussen, MA Khristova, ML Govil, D Sammons, SA Regnery, RL Karem, KL Damon, IK Carroll, DS AF Emerson, Ginny L. Li, Yu Frace, Michael A. Olsen-Rasmussen, Melissa A. Khristova, Marina L. Govil, Dhwani Sammons, Scott A. Regnery, Russell L. Karem, Kevin L. Damon, Inger K. Carroll, Darin S. TI The Phylogenetics and Ecology of the Orthopoxviruses Endemic to North America SO PLOS ONE LA English DT Article ID MONKEYPOX VIRUS; POXVIRUS GENOME; AVIAN POX; SEQUENCE; COWPOX; INFECTION; TRANSMISSION; EVOLUTION; INFERENCE; ALIGNMENT AB The data presented herein support the North American orthopoxviruses (NA OPXV) in a sister relationship to all other currently described Orthopoxvirus (OPXV) species. This phylogenetic analysis reaffirms the identification of the NA OPXV as close relatives of "Old World'' (Eurasian and African) OPXV and presents high support for deeper nodes within the Chordopoxvirinae family. The natural reservoir host(s) for many of the described OPXV species remains unknown although a clear virus-host association exists between the genus OPXV and several mammalian taxa. The hypothesized host associations and the deep divergence of the OPXV/NA OPXV clades depicted in this study may reflect the divergence patterns of the mammalian faunas of the Old and New World and reflect a more ancient presence of OPXV on what are now the American continents. Genes from the central region of the poxvirus genome are generally more conserved than genes from either end of the linear genome due to functional constraints imposed on viral replication abilities. The relatively slower evolution of these genes may more accurately reflect the deeper history among the poxvirus group, allowing for robust placement of the NA OPXV within Chordopoxvirinae. Sequence data for nine genes were compiled from three NA OPXV strains plus an additional 50 genomes collected from Genbank. The current, gene sequence based phylogenetic analysis reaffirms the identification of the NA OPXV as the nearest relatives of "Old World'' OPXV and presents high support for deeper nodes within the Chordopoxvirinae family. Additionally, the substantial genetic distances that separate the currently described NA OPXV species indicate that it is likely that many more undescribed OPXV/NA OPXV species may be circulating among wild animals in North America. RP Emerson, GL (reprint author), Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, CCID, CDC, Atlanta, GA 30333 USA. EM DCarroll@cdc.gov NR 45 TC 23 Z9 24 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 29 PY 2009 VL 4 IS 10 AR e7666 DI 10.1371/journal.pone.0007666 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 512FP UT WOS:000271232000017 PM 19865479 ER PT J AU Hungerford, D Sullivent, E Thomas, K Wald, M Galle, M AF Hungerford, D. Sullivent, E. Thomas, K. Wald, M. Galle, M. TI Nonfatal Scald-Related Burns Among Adults Aged >= 65 Years-United States, 2001-2006 (Reprinted from MMWR, vol 58, pg 993-996, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Galle, M.] CDC, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 28 PY 2009 VL 302 IS 16 BP 1744 EP 1746 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 511FW UT WOS:000271150300009 ER PT J AU Evans, AS Agadi, S Siegel, JD Chung, WM Carlo, JT Uyeki, TM Sejvar, J Lindstrom, S Erdman, D Oberste, S Olsen, SJ Dawood, F Morgan, OW AF Evans, A. S. Agadi, S. Siegel, J. D. Chung, W. M. Carlo, J. T. Uyeki, T. M. Sejvar, J. Lindstrom, S. Erdman, D. Oberste, S. Olsen, S. J. Dawood, F. Morgan, O. W. TI Neurologic Complications Associated With Novel Influenza A (H1N1) Virus Infection in Children-Dallas, Texas, May 2009 (Reprinted from MMWR, vol 58, pg 773-778, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Evans, A. S.; Agadi, S.; Siegel, J. D.] Univ Texas SW Med Ctr, Dallas, TX USA. [Chung, W. M.; Carlo, J. T.] Dallas Cty Hlth & Human Svcs, Dallas, TX USA. [Dawood, F.; Morgan, O. W.] CDC, Atlanta, GA 30333 USA. RP Evans, AS (reprint author), Univ Texas SW Med Ctr, Dallas, TX USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 28 PY 2009 VL 302 IS 16 BP 1746 EP 1748 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 511FW UT WOS:000271150300010 ER PT J AU Sintasath, DM Wolfe, ND Zheng, HQ LeBreton, M Peeters, M Tamoufe, U Djoko, CF Diffo, JLD Mpoudi-Ngole, E Heneine, W Switzer, WM AF Sintasath, David M. Wolfe, Nathan D. Zheng, Hao Qiang LeBreton, Matthew Peeters, Martine Tamoufe, Ubald Djoko, Cyrille F. Diffo, Joseph L. D. Mpoudi-Ngole, Eitel Heneine, Walid Switzer, William M. TI Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey SO RETROVIROLOGY LA English DT Article ID COMPLETE NUCLEOTIDE-SEQUENCE; DOMAIN-BINDING MOTIF; IN-VIVO; TAX ONCOPROTEIN; PDZ DOMAIN; HTLV-I; INTERSPECIES TRANSMISSION; CERCOCEBUS-TORQUATUS; MOLECULAR-FEATURES; NONHUMAN-PRIMATES AB Background: The recent discoveries of novel human T-lymphotropic virus type 3 (HTLV-3) and highly divergent simian T-lymphotropic virus type 3 (STLV-3) subtype D viruses from two different monkey species in southern Cameroon suggest that the diversity and cross-species transmission of these retroviruses are much greater than currently appreciated. Results: We describe here the first full-length sequence of a highly divergent STLV-3d(Cmo8699AB) virus obtained by PCR-based genome walking using DNA from two dried blood spots (DBS) collected from a wild-caught Cercopithecus mona monkey. The genome of STLV-3d(Cmo8699AB) is 8913-bp long and shares only 77% identity to other PTLV-3s. Phylogenetic analyses using Bayesian and maximum likelihood inference clearly show that this highly divergent virus forms an independent lineage with high posterior probability and bootstrap support within the diversity of PTLV-3. Molecular dating of concatenated gag-pol-envtax sequences inferred a divergence date of about 115,117 years ago for STLV-3d(Cmo8699AB) indicating an ancient origin for this newly identified lineage. Major structural, enzymatic, and regulatory gene regions of STLV-3d(Cmo8699AB) are intact and suggest viral replication and a predicted pathogenic potential comparable to other PTLV-3s. Conclusion: When taken together, the inferred ancient origin of STLV-3d(Cmo8699AB), the presence of this highly divergent virus in two primate species from the same geographical region, and the ease with which STLVs can be transmitted across species boundaries all suggest that STLV-3d may be more prevalent and widespread. Given the high human exposure to nonhuman primates in this region and the unknown pathogenicity of this divergent PTLV-3, increased surveillance and expanded prevention activities are necessary. Our ability to obtain the complete viral genome from DBS also highlights further the utility of this method for molecular-based epidemiologic studies. C1 [Zheng, Hao Qiang; Heneine, Walid; Switzer, William M.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Sintasath, David M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. [Wolfe, Nathan D.; LeBreton, Matthew; Tamoufe, Ubald; Djoko, Cyrille F.; Diffo, Joseph L. D.] Global Viral Forecasting Initiat, San Francisco, CA 94105 USA. [Wolfe, Nathan D.] Stanford Univ, Program Human Biol, Stanford, CA 94305 USA. [Peeters, Martine] IRD, UMR 145, Montpellier, France. [Peeters, Martine] Univ Montpellier 1, Montpellier, France. [Mpoudi-Ngole, Eitel] Ctr Rech Serv Sante Armees, Yaounde, Cameroon. RP Switzer, WM (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM d.sintasath@malariaconsortium.org; nwofle@gvfi.org; hzheng@cdc.gov; mlebreton@gvfi.org; martine.peeters@ird.fr; utamoufe@gvfi.org; cdjoko@gvfi.org; jdiffo@gvfi.org; empoudi2001@yahoo.co.uk; wheneine@cdc.gov; bis3@cdc.gov FU FIC NIH HHS [5 K01 TW000003-05, 2 D 43 TW000010-17-AITRP, K01 TW000003]; NIH HHS [DP1 OD000370, DP1-OD000370] NR 70 TC 12 Z9 12 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD OCT 27 PY 2009 VL 6 AR 97 DI 10.1186/1742-4690-6-97 PG 17 WC Virology SC Virology GA 526NG UT WOS:000272296500001 PM 19860877 ER PT J AU Mernoli, MJ Tumpey, TM Jagger, BW Dugan, VG Sheng, ZM Qi, L Kash, JC Taubenberger, JK AF Mernoli, Matthew J. Tumpey, Terrence M. Jagger, Brett W. Dugan, Vivien G. Sheng, Zong-Mei Qi, Li Kash, John C. Taubenberger, Jeffery K. TI An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice SO VIROLOGY LA English DT Article DE Viruses; Influenza; Pandemic; Ferrets; Viral pathogenesis; Animal models; Swine influenza ID A VIRUSES; EUROPEAN PIGS; ORIGIN; HEMAGGLUTININ; EVOLUTION; VIRULENCE; PATHOGENESIS; INFECTIONS; EPIDEMIC; HUMANS AB The 1918 pandemic influenza virus has demonstrated significant pathogenicity in animal models and is the progenitor of 'classical' swine and modern seasonal human H1N1 lineages. Here we characterize the pathogenicity of an early 'classical' swine H1N1 influenza A virus isolated in 1931 compared to the pathogenicity of the 1918 pandemic virus and a seasonal H1N1 virus in mice and ferrets. A/Swine/Iowa/31 (Sw31) and the 1918 influenza viruses were uniformly lethal in mice at low doses and produced severe lung pathology. In ferrets, Sw31 and 1918 influenza viruses caused severe clinical disease and lung pathology with necrotizing bronchiolitis and alveolitis. The modern H I NI virus Caused little disease in either animal model. These findings revealed that in these models the virulence factors of the 1918 influenza virus are likely preserved in the Sw31 virus and suggest that early swine viruses may be a good surrogate model to study 1918 virulence and pathogenesis. Published by Elsevier Inc. C1 [Mernoli, Matthew J.; Jagger, Brett W.; Dugan, Vivien G.; Sheng, Zong-Mei; Qi, Li; Kash, John C.; Taubenberger, Jeffery K.] NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Tumpey, Terrence M.] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis,Collaborating Ctr I, Atlanta, GA USA. RP Taubenberger, JK (reprint author), NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, 33 N Dr,MSC 3203, Bethesda, MD 20892 USA. EM taubenbergerj@niaid.nih.gov FU NIH; MAID FX The Intramural Research Program of the NIH and the MAID supported this work. NR 42 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD OCT 25 PY 2009 VL 393 IS 2 BP 338 EP 345 DI 10.1016/j.virol.2009.08.021 PG 8 WC Virology SC Virology GA 511FC UT WOS:000271148300017 ER PT J AU Jamieson, DJ Honein, MA Rasmussen, SA MacFarlane, KF Olsen, SJ AF Jamieson, Denise J. Honein, Margaret A. Rasmussen, Sonja A. MacFarlane, Kitty F. Olsen, Sonja J. TI Pregnancy and H1N1 infection Authors' reply SO LANCET LA English DT Letter C1 [Jamieson, Denise J.; MacFarlane, Kitty F.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Honein, Margaret A.; Rasmussen, Sonja A.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Olsen, Sonja J.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Jamieson, DJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM djj0@cdc.gov NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD OCT 24 PY 2009 VL 374 IS 9699 BP 1417 EP 1418 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 512MZ UT WOS:000271255000019 ER PT J AU Brown, DW Anda, RF AF Brown, David W. Anda, Robert F. TI Adverse childhood experiences: origins of behaviors that sustain the HIV epidemic SO AIDS LA English DT Letter ID HOUSEHOLD DYSFUNCTION; ABUSE; RISK C1 Ctr Dis, Atlanta, GA USA. Ctr Control & Prevent, Atlanta, GA USA. RP Brown, DW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS K67, Atlanta, GA 30341 USA. EM dbrown6@cdc.gov NR 7 TC 2 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD OCT 23 PY 2009 VL 23 IS 16 BP 2231 EP 2233 DI 10.1097/QAD.0b013e3283314769 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 517FS UT WOS:000271599200024 PM 19823119 ER PT J AU Wilkins, EE Marcet, PL Sutcliffe, AC Howell, PI AF Wilkins, Elien E. Marcet, Paula L. Sutcliffe, Alice C. Howell, Paul I. TI Authentication scheme for routine verification of genetically similar laboratory colonies: a trial with Anopheles gambiae SO BMC BIOTECHNOLOGY LA English DT Article ID MOLECULAR-FORMS; INSERTION POLYMORPHISM; CULICIDAE; MOSQUITO; DIPTERA; DIFFERENTIATION; IDENTIFICATION; STRAINS; COLOR; FIELD AB Background: When rearing morphologically indistinguishable laboratory strains concurrently, the threat of unintentional genetic contamination is constant. Avoidance of accidental mixing of strains is difficult due to the use of common equipment, technician error, or the possibility of self relocation by adult mosquitoes ("free fliers"). In many cases, laboratory strains are difficult to distinguish because of morphological and genetic similarity, especially when laboratory colonies are isolates of certain traits from the same parental strain, such as eye color mutants, individuals with certain chromosomal arrangements or high levels of insecticide resistance. Thus, proving genetic integrity could seem incredibly time-consuming or impossible. On the other hand, lacking proof of genetically isolated laboratory strains could question the validity of research results. Results: We present a method for establishing authentication matrices to routinely distinguish and confirm that laboratory strains have not become physically or genetically mixed through contamination events in the laboratory. We show a specific example with application to Anopheles gambiae sensu stricto strains at the Malaria Research and Reference Reagent Resource Center. This authentication matrix is essentially a series of tests yielding a strain-specific combination of results. Conclusion: These matrix-based methodologies are useful for several mosquito and insect populations but must be specifically tailored and altered for each laboratory based on the potential contaminants available at any given time. The desired resulting authentication plan would utilize the least amount of routine effort possible while ensuring the integrity of the strains. C1 [Wilkins, Elien E.; Marcet, Paula L.; Sutcliffe, Alice C.; Howell, Paul I.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Sutcliffe, Alice C.] Vet Affairs, AREF, Atlanta, GA USA. RP Howell, PI (reprint author), Ctr Dis Control & Prevent CDC, Atlanta, GA USA. EM EWilkins@cdc.gov; PMarcet@cdc.gov; ASutcliffe@cdc.gov; PHowell1@cdc.gov OI Marcet, Paula/0000-0002-0676-3020 FU American Type Culture Collection; NIAID [N01-AI-85355] FX We appreciate the American Type Culture Collection and the NIAID-funded contract N01-AI-85355 for their financial and moral support for the operation of the MR4 and their cooperation in developing and implementing the subcontract to the CDC Foundation that makes this research possible. Thanks to Zhijian Tu and Tovi Lehmann for their insight into different methodologies. Thanks to Mark Benedict who established the original experiments and authentication methodologies and urged us to produce this document. A special thanks to all the donors of mosquito stocks to the MR4. NR 38 TC 0 Z9 0 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6750 J9 BMC BIOTECHNOL JI BMC Biotechnol. PD OCT 22 PY 2009 VL 9 AR 91 DI 10.1186/1472-6750-9-91 PG 10 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 520JP UT WOS:000271840600001 PM 19849838 ER PT J AU Barskey, AE Glasser, JW LeBaron, CW AF Barskey, Albert E. Glasser, John W. LeBaron, Charles W. TI Mumps resurgences in the United States: A historical perspective on unexpected elements SO VACCINE LA English DT Article DE Mumps; Mumps outbreak; Mumps vaccine; MMR vaccine; Waning immunity ID HIGHLY VACCINATED POPULATION; US MILITARY RECRUITS; LARGE OUTBREAK; MEASLES; IMMUNITY; ANTIBODIES; RUBELLA; EPIDEMIOLOGY; ADOLESCENTS; PERSISTENCE AB In 2006 the United States experienced the largest nationwide mumps epidemic in 20 years, primarily affecting college dormitory residents. Unexpected elements of the outbreak included very abrupt time course (75% of cases occurred within 90 days), geographic focality (85% of cases occurred in eight rural Midwestern states), rapid upward and downward shift in peak age-specific attack rate (5-9-year olds to 18-24-year olds, then back), and two-dose vaccine failure (63% of case-patients had received two doses). To construct a historical context in which to understand the recent outbreak, we reviewed US mumps surveillance data, vaccination coverage estimates, and relevant peer-reviewed literature for the period 1917-2008. Many of the unexpected features of the 2006 mumps outbreak had been reported several times previously in the US, e.g., the 1986-1987 mumps resurgence had extremely abrupt onset, rural geographic focality, and an upward-then-downward age shift. Evidence suggested recurrent mumps outbreak patterns were attributable to accumulation of susceptibles in dispersed situations where the risk of endemic disease exposure was low and were triggered when this susceptible population was brought together in crowded living conditions. The 2006 epidemic followed this pattern, with two unique variations: it was preceded by a period of very high vaccination rates and very low disease incidence and was characterized by two-dose failure rates among adults vaccinated in childhood. Data from the past 80 years suggest that preventing future mumps epidemics will depend on innovative measures to detect and eliminate build-up of susceptibles among highly vaccinated populations. Published by Elsevier Ltd. C1 [Barskey, Albert E.; Glasser, John W.; LeBaron, Charles W.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Barskey, AE (reprint author), Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,NE-MS A-47, Atlanta, GA 30333 USA. EM abarskey@cdc.gov NR 41 TC 53 Z9 59 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 19 PY 2009 VL 27 IS 44 BP 6186 EP 6195 DI 10.1016/j.vaccine.2009.06.109 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 515QB UT WOS:000271486100014 PM 19815120 ER PT J AU Chen, RT Clark, TA Halperin, SA AF Chen, Robert T. Clark, Thomas A. Halperin, Scott A. TI The yin and yang of paracetamol and paediatric immunisations SO LANCET LA English DT Editorial Material ID ACELLULAR PERTUSSIS VACCINES; ADVERSE REACTIONS; DTP VACCINATION C1 [Chen, Robert T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Clark, Thomas A.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA 30333 USA. Dalhousie Univ, Halifax, NS, Canada. RP Chen, RT (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM rtc1@cdc.gov NR 13 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD OCT 17 PY 2009 VL 374 IS 9698 BP 1305 EP 1306 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 512MW UT WOS:000271254600005 PM 19837236 ER PT J AU MacNeil, A Holman, RC Yorita, KL Steiner, CA Parashar, UD Belay, ED AF MacNeil, Adam Holman, Robert C. Yorita, Krista L. Steiner, Claudia A. Parashar, Umesh D. Belay, Ermias D. TI Evaluation of seasonal patterns of Kawasaki Syndrome- and rotavirus-associated hospitalizations in California and New York, 2000-2005 SO BMC PEDIATRICS LA English DT Article ID UNITED-STATES; INFECTION; DISEASE AB Background: Kawasaki Syndrome (KS) is an uncommon childhood disease with unknown etiology. It has been suggested that rotavirus infection may play a causative role in the development of KS. Methods: To examine potential temporal associations between KS and rotavirus infection, seasonal patterns of KS- and rotavirus-associated hospitalizations among children in California and New York during 2000-2005 were compared. Results: Rotavirus hospital admissions were markedly winter seasonal, with very few summer hospitalizations. KS hospitalizations occurred year-round but also peaked slightly during winter and spring. Conclusion: The strong winter seasonal pattern of rotavirus clearly differed from the year-round pattern of KS hospitalizations. While the present study cannot completely rule out rotavirus as having a role in the development of KS, other agents must be involved in the etiology of KS. C1 [MacNeil, Adam; Holman, Robert C.; Yorita, Krista L.; Belay, Ermias D.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, US Dept HHS, Atlanta, GA 30333 USA. [Steiner, Claudia A.] US Dept HHS, Healthcare Cost & Utilizat Project, Ctr Delivery Org & Markets, Agcy Healthcare Res & Qual, Rockville, MD USA. [Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, US Dept HHS, Atlanta, GA USA. RP MacNeil, A (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, US Dept HHS, Atlanta, GA 30333 USA. EM aho3@cdc.gov; rch1@cdc.gov; KYorita@cdc.gov; Claudia.Steiner@ahrq.hhs.gov; uap2@cdc.gov; ebb8@cdc.gov RI Belay, Ermias/A-8829-2013 FU California Office of Statewide Health Planning Development; New York State Department of Health; Healthcare Cost and Utilization Project; Centers for Disease Control and Prevention FX The authors thank the California Office of Statewide Health Planning & Development, and the New York State Department of Health for their support and participation in the Healthcare Cost and Utilization Project. Work was funded entirely by the Centers for Disease Control and Prevention. The authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. NR 12 TC 8 Z9 9 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2431 J9 BMC PEDIATR JI BMC Pediatr. PD OCT 16 PY 2009 VL 9 AR 65 DI 10.1186/1471-2431-9-65 PG 4 WC Pediatrics SC Pediatrics GA 513MG UT WOS:000271325800001 PM 19835612 ER PT J AU Johnson, DP Wilson, JS Luber, GC AF Johnson, Daniel P. Wilson, Jeffrey S. Luber, George C. TI Socioeconomic indicators of heat-related health risk supplemented with remotely sensed data SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS LA English DT Article ID LAND-SURFACE TEMPERATURE; CLIMATE-CHANGE; PUBLIC PERCEPTION; UNITED-STATES; HOT WEATHER; MORTALITY; VULNERABILITY; CITIES; PHILADELPHIA; DISEASES AB Background: Extreme heat events are the number one cause of weather-related fatalities in the United States. The current system of alert for extreme heat events does not take into account intra-urban spatial variation in risk. The purpose of this study is to evaluate a potential method to improve spatial delineation of risk from extreme heat events in urban environments by integrating sociodemographic risk factors with estimates of land surface temperature derived from thermal remote sensing data. Results: Comparison of logistic regression models indicates that supplementing known sociodemographic risk factors with remote sensing estimates of land surface temperature improves the delineation of intra-urban variations in risk from extreme heat events. Conclusion: Thermal remote sensing data can be utilized to improve understanding of intra-urban variations in risk from extreme heat. The refinement of current risk assessment systems could increase the likelihood of survival during extreme heat events and assist emergency personnel in the delivery of vital resources during such disasters. C1 [Johnson, Daniel P.; Wilson, Jeffrey S.] Indiana Univ Purdue Univ, Sch Liberal Arts, Dept Geog, Indianapolis, IN 46202 USA. [Luber, George C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Johnson, DP (reprint author), Indiana Univ Purdue Univ, Sch Liberal Arts, Dept Geog, Indianapolis, IN 46202 USA. EM dpjohnso@iupui.edu; jeswilso@iupui.edu; gcl4@cdc.gov NR 61 TC 39 Z9 39 U1 0 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-072X J9 INT J HEALTH GEOGR JI Int. J. Health Geogr. PD OCT 16 PY 2009 VL 8 AR 57 DI 10.1186/1476-072X-8-57 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 515GG UT WOS:000271455300001 PM 19835578 ER PT J AU Cogswell, ME Bitsko, RH Anderka, M Caton, AR Feldkamp, ML Sherlock, SMH Meyer, RE Ramadhani, T Robbins, JM Shaw, GM Mathews, TJ Royle, M Reefhuis, J AF Cogswell, Mary E. Bitsko, Rebecca H. Anderka, Marlene Caton, Alissa R. Feldkamp, Marcia L. Sherlock, Stacey M. Hockett Meyer, Robert E. Ramadhani, Tunu Robbins, James M. Shaw, Gary M. Mathews, T. J. Royle, Marjorie Reefhuis, Jennita CA Natl Birth Defects Prevention TI Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE case-control studies; congenital abnormalities; selection bias ID CONGENITAL HEART-DEFECTS; MATERNAL SMOKING; VALID SELECTION; WOMEN; RISK; PREVENTION; PREGNANCY AB To evaluate the representativeness of controls in an ongoing, population-based, case-control study of birth defects in 10 centers across the United States, researchers compared 1997-2003 birth certificate data linked to selected controls (n = 6,681) and control participants (n = 4,395) with those from their base populations (n = 2,468,697). Researchers analyzed differences in population characteristics (e.g., percentage of births at >= 2,500 g) for each group. Compared with their base populations, control participants did not differ in distributions of maternal or paternal age, previous livebirths, maternal smoking, or diabetes, but they did differ in other maternal (i.e., race/ethnicity, education, entry into prenatal care) and infant (i.e., birth weight, gestational age, and plurality) characteristics. Differences in distributions of maternal, but not infant, characteristics were associated with participation by selected controls. Absolute differences in infant characteristics for the base population versus control participants were < 1.3 percentage points. Differences in infant characteristics were greater at centers that selected controls from hospitals compared with centers that selected controls from electronic birth certificates. These findings suggest that control participants in the National Birth Defects Prevention Study generally are representative of their base populations. Hospital-based control selection may slightly underascertain infants affected by certain adverse birth outcomes. C1 [Cogswell, Mary E.; Bitsko, Rebecca H.; Reefhuis, Jennita] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30329 USA. [Anderka, Marlene] Massachusetts Dept Publ Hlth, Bur Family Hlth & Nutr, Boston, MA USA. [Caton, Alissa R.] New York State Dept Hlth, Congenital Malformat Registry, Troy, NY USA. [Feldkamp, Marcia L.] Utah Dept Hlth, Salt Lake City, UT 84116 USA. [Sherlock, Stacey M. Hockett] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA. [Meyer, Robert E.] N Carolina State Ctr Hlth Stat, N Carolina Birth Defects Monitoring Program, Raleigh, NC USA. [Ramadhani, Tunu] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA. [Robbins, James M.] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA. [Shaw, Gary M.] Stanford Univ, Dept Pediat, Div Neonatol & Dev Med, Palo Alto, CA 94304 USA. [Mathews, T. J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Vital Stat, Hyattsville, MD 20782 USA. [Royle, Marjorie] New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA. RP Cogswell, ME (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Mailstop E-86,1600 Clifton Rd NE,MS E-86, Atlanta, GA 30329 USA. EM mcogswell@cdc.gov RI Reefhuis, Jennita/E-1793-2011; Publications, NBDPS/B-7692-2013; OI Reefhuis, Jennita/0000-0002-4747-4831; Robbins, James/0000-0003-2200-1947 FU Centers for Disease Control and Prevention FX This study was supported by a cooperative agreement from the Centers for Disease Control and Prevention. NR 21 TC 80 Z9 80 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 15 PY 2009 VL 170 IS 8 BP 975 EP 985 DI 10.1093/aje/kwp226 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 502GT UT WOS:000270445300007 PM 19736223 ER PT J AU Roberts, RR Hota, B Ahmad, I Scott, RD Foster, SD Abbasi, F Schabowski, S Kampe, LM Ciavarella, GG Supino, M Naples, J Cordell, R Levy, SB Weinstein, RA AF Roberts, Rebecca R. Hota, Bala Ahmad, Ibrar Scott, R. Douglas, II Foster, Susan D. Abbasi, Fauzia Schabowski, Shari Kampe, Linda M. Ciavarella, Ginevra G. Supino, Mark Naples, Jeremy Cordell, Ralph Levy, Stuart B. Weinstein, Robert A. TI Hospital and Societal Costs of Antimicrobial-Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; LENGTH-OF-STAY; STAPHYLOCOCCUS-AUREUS; ECONOMIC OUTCOMES; NOSOCOMIAL INFECTIONS; MEDICAL LITERATURE; CRITICAL-APPRAISAL; DECISION-SUPPORT; DRUG DEVELOPMENT; CDC DEFINITIONS AB Background. Organisms resistant to antimicrobials continue to emerge and spread. This study was performed to measure the medical and societal cost attributable to antimicrobial-resistant infection (ARI). Methods. A sample of high-risk hospitalized adult patients was selected. Measurements included ARI, total cost, duration of stay, comorbidities, acute pathophysiology, Acute Physiology and Chronic Health Evaluation III score, intensive care unit stay, surgery, health care-acquired infection, and mortality. Hospital services used and outcomes were abstracted from electronic and written medical records. Medical costs were measured from the hospital perspective. A sensitivity analysis including 3 study designs was conducted. Regression was used to adjust for potential confounding in the random sample and in the sample expanded with additional patients with ARI. Propensity scores were used to select matched control subjects for each patient with ARI for a comparison of mean cost for patients with and without ARI. Results. In a sample of 1391 patients, 188 (13.5%) had ARI. The medical costs attributable to ARI ranged from $18,588 to $29,069 per patient in the sensitivity analysis. Excess duration of hospital stay was 6.4-12.7 days, and attributable mortality was 6.5%. The societal costs were $10.7-$15.0 million. Using the lowest estimates from the sensitivity analysis resulted in a total cost of $13.35 million in 2008 dollars in this patient cohort. Conclusions. The attributable medical and societal costs of ARI are considerable. Data from this analysis could form the basis for a more comprehensive evaluation of the cost of resistance and the potential economic benefits of prevention programs. C1 [Roberts, Rebecca R.] John H Stroger Jr Hosp Cook Cty, Div Res, Dept Emergency Med, Chicago, IL 60612 USA. [Weinstein, Robert A.] John H Stroger Jr Hosp Cook Cty, Dept Med, Chicago, IL 60612 USA. [Hota, Bala; Weinstein, Robert A.] John H Stroger Jr Hosp Cook Cty, Div Infect Dis, Chicago, IL 60612 USA. [Kampe, Linda M.] Cook Cty Hlth & Hosp Syst, Cermak Hlth Serv, Dept Med Records, Chicago, IL USA. [Ciavarella, Ginevra G.] Univ Illinois, Nursing Serv, Chicago, IL USA. [Hota, Bala; Schabowski, Shari; Weinstein, Robert A.] Rush Univ, Coll Med, Chicago, IL 60612 USA. [Scott, R. Douglas, II] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. [Cordell, Ralph] Ctr Dis Control & Prevent, Coordinating Ctr Hlth Informat & Serv, Atlanta, GA USA. [Foster, Susan D.; Levy, Stuart B.] Alliance Prudent Use Antibiot, Boston, MA USA. [Levy, Stuart B.] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA. [Levy, Stuart B.] Tufts Univ, Dept Med, Boston, MA 02111 USA. [Abbasi, Fauzia] Fairfax Cty Publ Safety Occupat Hlth Ctr, Fairfax, VA USA. RP Roberts, RR (reprint author), John H Stroger Jr Hosp Cook Cty, Div Res, Dept Emergency Med, 1900 W Polk,10th Fl, Chicago, IL 60612 USA. EM rroberts@ccbh.org FU bioMerieux; Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention; [U50/CCU515853] FX This work was supported through an initiative of the Alliance for the Prudent Use of Antibiotics under an unrestricted education grant from bioMerieux and with the Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention (cooperative agreement U50/CCU515853). NR 50 TC 236 Z9 243 U1 3 U2 37 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2009 VL 49 IS 8 BP 1175 EP 1184 DI 10.1086/605630 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 499NY UT WOS:000270230100007 PM 19739972 ER PT J AU Heuer, OE Kruse, H Grave, K Collignon, P Karunasagar, I Angulo, FJ AF Heuer, Ole E. Kruse, Hilde Grave, Kari Collignon, P. Karunasagar, Iddya Angulo, Frederick J. TI Human Health Consequences of Use of Antimicrobial Agents in Aquaculture SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID QUINOLONE RESISTANCE DETERMINANTS; ANTIBIOTIC-RESISTANCE; SEROTYPE TYPHIMURIUM; MANGROVE AREAS; BACTERIA; SHRIMP; SALMONELLA; FISH; PLASMID; GENES AB Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly. Horizontal gene transfer may occur in the aquaculture environment, in the food chain, or in the human intestinal tract. Among the antimicrobial agents commonly used in aquaculture, several are classified by the World Health Organisation as critically important for use in humans. Occurrence of resistance to these antimicrobial agents in human pathogens severely limits the therapeutic options in human infections. Considering the rapid growth and importance of aquaculture industry in many regions of the world and the widespread, intensive, and often unregulated use of antimicrobial agents in this area of animal production, efforts are needed to prevent development and spread of antimicrobial resistance in aquaculture to reduce the risk to human health. C1 [Heuer, Ole E.] Tech Univ Denmark, Natl Food Inst, Danish Zoonosis Ctr, Soborg, Denmark. [Kruse, Hilde] Natl Vet Inst, Oslo, Norway. [Grave, Kari] Norwegian Sch Vet Sci, Dept Food Safety & Infect Biol, Oslo, Norway. [Collignon, P.] Australian Natl Univ, Canberra Hosp, Infect Dis Unit, Canberra, ACT, Australia. [Collignon, P.] Australian Natl Univ, Canberra Hosp, Dept Microbiol, Canberra, ACT, Australia. [Collignon, P.] Australian Natl Univ, Sch Clin Med, Canberra, ACT, Australia. [Karunasagar, Iddya] Karnataka Vet Anim & Fisheries Sci Univ, Dept Fishery Microbiol, Mangalore, India. [Angulo, Frederick J.] Ctr Dis Control & Prevent, Dept Enter Dis, Epidemiol Branch, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA USA. RP Heuer, OE (reprint author), European Ctr Dis Prevent & Control, Tomtebodavagen 11A, SE-17183 Stockholm, Sweden. EM ole.heuer@.ecdc.europa.eu NR 39 TC 111 Z9 113 U1 5 U2 42 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2009 VL 49 IS 8 BP 1248 EP 1253 DI 10.1086/605667 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 499NY UT WOS:000270230100017 PM 19772389 ER PT J AU Gould, C Allen-Bridson, K Horan, T AF Gould, Carolyn Allen-Bridson, Katherine Horan, Teresa TI Surveillance Definitions for Urinary Tract Infections SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Gould, Carolyn; Allen-Bridson, Katherine; Horan, Teresa] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Gould, C (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,Mailstop A 35, Atlanta, GA 30333 USA. EM CGould@cdc.gov NR 2 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2009 VL 49 IS 8 BP 1288 EP 1289 DI 10.1086/605692 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 499NY UT WOS:000270230100027 PM 19780667 ER PT J AU Harris, JR Greene, SK Thomas, TK Ndivo, R Okanda, J Masaba, R Nyangau, I Thigpen, MC Hoekstra, RM Quick, RE AF Harris, Julie R. Greene, Sharon K. Thomas, Timothy K. Ndivo, Richard Okanda, John Masaba, Rose Nyangau, Isabel Thigpen, Michael C. Hoekstra, Robert M. Quick, Robert E. TI Effect of a Point-of-Use Water Treatment and Safe Water Storage Intervention on Diarrhea in Infants of HIV-Infected Mothers SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 15th Conference on Retroviruses and Opportunistic Infections CY FEB 03-06, 2008 CL Boston, MA ID TO-CHILD TRANSMISSION; HUMAN-IMMUNODEFICIENCY-VIRUS; RANDOMIZED CONTROLLED-TRIAL; RURAL WESTERN KENYA; WEANING FOOD; BACTERIAL DIARRHEA; PREVENTION; SURVIVAL; RISK; COMMUNITY AB To reduce mother-to-child transmission of human immunodeficiency virus (HIV) in resource-poor settings, the World Health Organization recommends exclusive breast-feeding for 6 months, followed by rapid weaning if replacement feeding is affordable, feasible, available, safe, and sustainable. In the Kisumu Breastfeeding Study (trial registration: Clinicaltrials.gov identifier NCT00146380), infants of HIV-infected mothers who received antiretroviral therapy experienced high rates of diarrhea at weaning. To address this problem, mothers in the Kisumu Breastfeeding Study were given safe water storage vessels, hygiene education, and bleach for household water treatment. We compared the incidence of diarrhea in infants enrolled before (cohort A) and after (cohort B) implementation of the intervention. Cohort B infants experienced less diarrhea than cohort A infants, before and after weaning (P < .001 and P = .047, respectively); however, during the weaning period, there were no differences in the frequency of diarrhea between cohorts (P = 0.89). Testing of stored water in cohort B homes indicated high adherence (monthly range, 80%-95%) to recommended chlorination practices. Among infants who were weaned early, provision of safe water may be insufficient to prevent weaning-associated diarrhea. C1 [Harris, Julie R.; Greene, Sharon K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Harris, Julie R.; Greene, Sharon K.; Hoekstra, Robert M.; Quick, Robert E.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Thomas, Timothy K.; Thigpen, Michael C.] Ctr Dis Control & Prevent, Div HIV AIDS Prevention Surveillance & Epidemiol, Natl Ctr HIV AIDS, Atlanta, GA USA. [Ndivo, Richard; Okanda, John; Masaba, Rose; Nyangau, Isabel] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Thomas, Timothy K.; Ndivo, Richard; Okanda, John; Masaba, Rose; Nyangau, Isabel] Ctr Dis Control & Prevent, Kisumu, Kenya. RP Harris, JR (reprint author), 1600 Clifton Rd NE,MS D-63, Atlanta, GA 30329 USA. EM ggt5@cdc.gov NR 40 TC 25 Z9 25 U1 1 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 15 PY 2009 VL 200 IS 8 BP 1186 EP 1193 DI 10.1086/605841 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 497UV UT WOS:000270089400002 PM 19758095 ER PT J AU Parikh, UM Dobard, C Sharma, S Cong, ME Jia, HW Martin, A Pau, CP Hanson, DL Guenthner, P Smith, J Kersh, E Garcia-Lerma, JG Novembre, FJ Otten, R Folks, T Heneine, W AF Parikh, Urvi M. Dobard, Charles Sharma, Sunita Cong, Mian-er Jia, Hongwei Martin, Amy Pau, Chou-Pong Hanson, Debra L. Guenthner, Patricia Smith, James Kersh, Ellen Garcia-Lerma, J. Gerardo Novembre, Francis J. Otten, Ron Folks, Thomas Heneine, Walid TI Complete Protection from Repeated Vaginal Simian-Human Immunodeficiency Virus Exposures in Macaques by a Topical Gel Containing Tenofovir Alone or with Emtricitabine SO JOURNAL OF VIROLOGY LA English DT Article ID HIV PRECLINICAL INTERVENTIONS; FEMALE SEX WORKERS; NONHUMAN-PRIMATES; RHESUS MACAQUES; INTRAVAGINAL INOCULATION; SHIV TRANSMISSION; INFECTION; PREVENTION; RISK; MARRIAGE AB New-generation gels that deliver potent antiretroviral drugs against human immunodeficiency virus type 1 have renewed hopes for topical prophylaxis as a prevention strategy. Previous preclinical research with monkey models suggested that high concentrations and drug combinations are needed for high efficacy. We evaluated two long-acting reverse transcriptase inhibitors, tenofovir (TFV) and emtricitabine (FTC), by using a twice-weekly repeat challenge macaque model and showed that a preexposure vaginal application of gel with 1% TFV alone or in combination with 5% FTC fully protected macaques from a total of 20 exposures to simian-human immunodeficiency virus SF162p3. FTC and TFV were detected in plasma 30 min after vaginal application, suggesting rapid absorption. FTC was detected more frequently than TFV and showed higher levels, reflecting the fivefold-higher concentration of this drug than of TFV. Two of 12 repeatedly exposed but protected macaques showed limited T-cell priming, which did not induce resistance to infection when macaques were rechallenged. Thus, single drugs with durable antiviral activity can provide highly effective topical prophylaxis and overcome the need for noncoital use or for drug combinations which are more complex and costly to formulate and approve. C1 [Parikh, Urvi M.; Dobard, Charles; Sharma, Sunita; Cong, Mian-er; Jia, Hongwei; Martin, Amy; Pau, Chou-Pong; Guenthner, Patricia; Smith, James; Kersh, Ellen; Garcia-Lerma, J. Gerardo; Otten, Ron; Heneine, Walid] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. [Hanson, Debra L.] Ctr Dis Control & Prevent, Quantitat Sci & Data Management Branch, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. [Novembre, Francis J.] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA. [Folks, Thomas] SW Fdn Biomed Res, San Antonio, TX 78284 USA. RP Heneine, W (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, 1600 Clifton Rd, Atlanta, GA 30329 USA. EM wmh2@cdc.gov FU AIDS Research and Reference Reagent Program, Division of AIDS (DAIDS); National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health; Janet Harouse, Cecilia Cheng-Mayer, and Ranajit Pal.; [RR00165] FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Use of trade names is for identification purposes only and does not constitute endorsement by the U. S. Centers for Disease Control and Prevention or the Department of Health and Human Services. NR 51 TC 132 Z9 137 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT 15 PY 2009 VL 83 IS 20 BP 10358 EP 10365 DI 10.1128/JVI.01073-09 PG 8 WC Virology SC Virology GA 498FC UT WOS:000270121600004 PM 19656878 ER PT J AU Billharz, R Zeng, H Proll, SC Korth, MJ Lederer, S Albrecht, R Goodman, AG Rosenzweig, E Tumpey, TM Garcia-Sastre, A Katze, MG AF Billharz, Rosalind Zeng, Hui Proll, Sean C. Korth, Marcus J. Lederer, Sharon Albrecht, Randy Goodman, Alan G. Rosenzweig, Elizabeth Tumpey, Terrence M. Garcia-Sastre, Adolfo Katze, Michael G. TI The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways SO JOURNAL OF VIROLOGY LA English DT Article ID DOUBLE-STRANDED-RNA; PRE-MESSENGER-RNAS; A-VIRUS; INFECTED-CELLS; IMMUNE-RESPONSE; BINDING MOTIF; UP-REGULATION; RIG-I; GENES; ACTIVATION AB The "Spanish influenza" of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response to the eight-gene 1918 virus. To better understand the role of the 1918 virus NS1 gene, we also evaluated the host response to a reassortant 1918 virus containing the NS1 gene from A/Texas/36/91 (a seasonal isolate of human influenza virus), as well as the host response to a reassortant of A/Texas/36/91 containing the 1918 NS1 gene. Genomic analyses revealed that the 1918 virus blocked the transcription of multiple interferon-stimulated genes and also downregulated a network of genes associated with lipid metabolism. In contrast, the expression of genes encoding chemokines and cytokines, which serve to attract infiltrating immune cells, was upregulated. Viruses containing the NS1 gene from A/Texas/36/91 induced a significant increase in type I interferon signaling but did not repress lipid metabolism. The 1918 NS1 gene may therefore have contributed to the virulence of the 1918 pandemic virus by disrupting the innate immune response, inducing hypercytokinemia, and by blocking the transcription of certain lipid-based proinflammatory mediators that function as part of the host antiviral response. C1 [Billharz, Rosalind; Proll, Sean C.; Korth, Marcus J.; Lederer, Sharon; Goodman, Alan G.; Rosenzweig, Elizabeth; Katze, Michael G.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Billharz, Rosalind; Proll, Sean C.; Korth, Marcus J.; Lederer, Sharon; Goodman, Alan G.; Rosenzweig, Elizabeth; Katze, Michael G.] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA. [Zeng, Hui; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Albrecht, Randy; Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Microbiol, New York, NY USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY USA. RP Katze, MG (reprint author), Univ Washington, Dept Microbiol, Box 358070, Seattle, WA 98195 USA. EM honey@u.washington.edu OI Garcia-Sastre, Adolfo/0000-0002-6551-1827; Albrecht, Randy/0000-0003-4008-503X FU National Institute of Allergy and Infectious Diseases [P01AI058113] FX This work was supported by Public Health Service grant P01AI058113 from the National Institute of Allergy and Infectious Diseases. NR 55 TC 43 Z9 43 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT 15 PY 2009 VL 83 IS 20 BP 10557 EP 10570 DI 10.1128/JVI.00330-09 PG 14 WC Virology SC Virology GA 498FC UT WOS:000270121600023 PM 19706713 ER PT J AU Finkbeiner, SR Li, Y Ruone, S Conrardy, C Gregoricus, N Toney, D Virgin, HW Anderson, LJ Vinje, J Wang, D Tong, SX AF Finkbeiner, Stacy R. Li, Yan Ruone, Susan Conrardy, Christina Gregoricus, Nicole Toney, Denise Virgin, Herbert W. Anderson, Larry J. Vinje, Jan Wang, David Tong, Suxiang TI Identification of a Novel Astrovirus (Astrovirus VA1) Associated with an Outbreak of Acute Gastroenteritis SO JOURNAL OF VIROLOGY LA English DT Article ID CHILDREN; DIARRHEA; NOROVIRUS; SEQUENCE; GENOME; VIRUS AB The etiology of a large proportion of gastrointestinal illness is unknown. In this study, random Sanger sequencing and pyrosequencing approaches were used to analyze fecal specimens from a gastroenteritis outbreak of unknown etiology in a child care center. Multiple sequences with limited identity to known astroviruses were identified. Assembly of the sequences and subsequent reverse transcription-PCR (RT-PCR) and rapid amplification of cDNA ends generated a complete genome of 6,586 nucleotides. Phylogenetic analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all previously described astroviruses. Based on RT-PCR, specimens from multiple patients in this outbreak were unequivocally positive for Ast-VA1. C1 [Finkbeiner, Stacy R.; Virgin, Herbert W.; Wang, David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. [Finkbeiner, Stacy R.; Virgin, Herbert W.; Wang, David] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA. [Li, Yan; Ruone, Susan; Conrardy, Christina; Gregoricus, Nicole; Anderson, Larry J.; Vinje, Jan; Tong, Suxiang] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Toney, Denise] Consolidated Lab Serv, Commonwealth Virginia Div, Richmond, VA 23219 USA. RP Wang, D (reprint author), Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. EM davewang@borcim.wustl.edu; stong@cdc.gov OI Vinje, Jan/0000-0002-1530-3675 FU National Institutes of Health [U54 AI057160]; Burroughs Wellcome Fund FX This work was supported in part by National Institutes of Health grant U54 AI057160 to the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research. D. W. holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund. NR 22 TC 95 Z9 102 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT 15 PY 2009 VL 83 IS 20 BP 10836 EP 10839 DI 10.1128/JVI.00998-09 PG 4 WC Virology SC Virology GA 498FC UT WOS:000270121600049 PM 19706703 ER PT J AU Cisternas, MG Murphy, L Croft, JB Helmick, CG AF Cisternas, M. G. Murphy, L. Croft, J. B. Helmick, C. G. TI Racial Disparities in Total Knee Replacement Among Medicare Enrollees-United States, 2000-2006 (Reprinted from MMWR, vol 58, pg 133-138, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID ARTHROPLASTY C1 [Cisternas, M. G.] MGC Data Svcs, Carlsbad, CA USA. [Murphy, L.; Croft, J. B.; Helmick, C. G.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30333 USA. RP Cisternas, MG (reprint author), MGC Data Svcs, Carlsbad, CA USA. NR 11 TC 0 Z9 0 U1 1 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 14 PY 2009 VL 302 IS 14 BP 1525 EP 1526 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 505UA UT WOS:000270721800009 ER PT J AU Frieden, TR Teklehaimanot, A Chideya, S Farmer, P Kim, JY Raviglione, MC AF Frieden, Thomas R. Teklehaimanot, Awash Chideya, Sekai Farmer, Paul Kim, Jim Y. Raviglione, Mario C. TI A Road Map to Control Malaria, Tuberculosis, and Human Immunodeficiency Virus/AIDS SO ARCHIVES OF INTERNAL MEDICINE LA English DT Editorial Material ID ANTIRETROVIRAL THERAPY; AFRICA; HIV C1 [Frieden, Thomas R.; Teklehaimanot, Awash; Chideya, Sekai; Farmer, Paul; Kim, Jim Y.; Raviglione, Mario C.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM tfrieden@cdc.gov NR 15 TC 2 Z9 2 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD OCT 12 PY 2009 VL 169 IS 18 BP 1650 EP 1652 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 505GL UT WOS:000270680000001 PM 19822819 ER PT J AU Blossom, D Noble-Wang, J Su, J Pur, S Chemaly, R Shams, A Jensen, B Pascoe, N Gullion, J Casey, E Hayden, M Arduino, M Budnitz, DS Raad, I Trenholme, G Srinivasan, A AF Blossom, Dave Noble-Wang, Judith Su, John Pur, Stacy Chemaly, Roy Shams, Alicia Jensen, Bette Pascoe, Neil Gullion, Jessica Casey, Eric Hayden, Mary Arduino, Matthew Budnitz, Daniel S. Raad, Isaam Trenholme, Gordon Srinivasan, Arjun TI Multistate Outbreak of (Serratia marcescens) Bloodstream Infections Caused by Contamination of Prefilled Heparin and Isotonic Sodium Chloride Solution Syringes SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID EXTRINSIC CONTAMINATION; PHARMACY; SOAP AB Background: To investigate clusters of Serratia marcescens (SM) bloodstream infections (BSIs) at health care facilities in several states and determine whether contaminated prefilled heparin and isotonic sodium chloride solution (hereinafter, saline) syringes from a single manufacturer (company X) were the likely cause, we performed an outbreak investigation of inpatient and outpatient health care facilities from October 2007 through February 2008. Methods: Active case finding for clusters of SM BSIs. Information on SM BSIs was obtained, and SM blood isolates were sent to the Centers for Disease Control and Prevention (CDC). Culture specimens were taken from various lots of prefilled heparin and saline syringes by health care facilities and the CDC to test for the presence of SM. The SM isolates from syringes and blood were compared by pulsed-field gel electrophoresis. Results: A total of 162 SM BSIs in 9 states were reported among patients at facilities using prefilled heparin and/or saline syringes made by company X. Cultures of unopened prefilled heparin and saline syringes manufactured by company X grew SM. Of 83 SM blood isolates submitted to the CDC from 7 states, 70 (84%) were genetically related to the SM strain isolated from prefilled syringes. A US Food and Drug Administration inspection revealed that company X was not in compliance with quality system regulations. Conclusions: A multistate outbreak of SM BSIs was associated with intrinsic contamination of prefilled syringes. Our investigation highlights important issues in medication safety, including (1) the importance of pursuing possible product-associated outbreaks suggested by strong epidemiologic data even when initial cultures of the suspected product show no contamination and (2) the challenges of medical product recalls when production has been outsourced from one company to another. Arch Intern Med. 2009;169(18):1705-1711 RP Srinivasan, A (reprint author), CDCP, Div Hlthcare Qual Prom, 1600 Clifton Rd, Mail Stop A35, Atlanta, GA 30333 USA. EM Beu8cdc.gov RI Arduino, Matthew/C-1461-2012 OI Arduino, Matthew/0000-0001-7072-538X NR 19 TC 15 Z9 16 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD OCT 12 PY 2009 VL 169 IS 18 BP 1705 EP 1711 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 505GL UT WOS:000270680000018 PM 19822828 ER PT J AU Jones, JF Lin, JMS Maloney, EM Boneva, RS Nater, UM Unger, ER Reeves, WC AF Jones, James F. Lin, Jin-Mann S. Maloney, Elizabeth M. Boneva, Roumiana S. Nater, Urs M. Unger, Elizabeth R. Reeves, William C. TI An evaluation of exclusionary medical/psychiatric conditions in the definition of chronic fatigue syndrome SO BMC MEDICINE LA English DT Article ID CARE; ILLNESS; SF-36 AB Background: The diagnosis of chronic fatigue syndrome (CFS) in research studies requires the exclusion of subjects with medical and psychiatric conditions that could confound the analysis and interpretation of results. This study compares illness parameters between individuals with CFS who have and those who do not have exclusionary conditions. Methods: We used a population-based telephone survey of randomly selected individuals, followed by a clinical evaluation in the study metropolitan, urban, and rural counties of Georgia, USA. The medical and psychiatric histories of the subjects were examined and they underwent physical and psychiatric examinations and laboratory screening. We also employed the multidimensional fatigue inventory (MFI), the medical outcomes survey short form-36 (SF-36) and the US Centres for Disease Control and Prevention symptom inventory (SI). Results: Twenty-nine percent (1,609) of the 5623 subjects who completed the detailed telephone interview reported exclusionary diagnoses and we diagnosed an exclusionary condition in 36% of 781 clinically evaluated subjects. Both medical and psychiatric exclusionary conditions were more common in women, blacks and participants from rural areas. Subjects with and without exclusions had similar levels of fatigue and impairment as measured by the MFI and SF-36; those with CFS-like illness (not meeting the formal CFS definition) were more likely to have an exclusionary diagnosis. After adjusting for demographics, body mass index, fatigue subscales, SF-36 subscales and CFS symptoms, CFS-like illness did not remain significantly associated with having an exclusionary diagnosis. Conclusion: Medical and psychiatric illnesses associated with fatigue are common among the unwell. Those who fulfill CFS-like criteria need to be evaluated for potentially treatable conditions. Those with exclusionary conditions are equally impaired as those without exclusions. C1 [Jones, James F.; Lin, Jin-Mann S.; Maloney, Elizabeth M.; Boneva, Roumiana S.; Nater, Urs M.; Unger, Elizabeth R.; Reeves, William C.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA. [Nater, Urs M.] Univ Zurich, Dept Psychol Clin Psychol & Psychotherapy, CH-8050 Zurich, Switzerland. RP Jones, JF (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Coordinating Ctr Infect Dis, 1600 Clifton Rd,MS A15, Atlanta, GA 30333 USA. EM jaj9@cdc.gov; dwe3@cdc.gov; evm3@cdc.gov; rrb5@cdc.gov; u.nater@psychologie.uzh.ch; eru0@cdc.gov; wcr1@cdc.gov RI Nater, Urs/J-6898-2013; OI Nater, Urs/0000-0002-2430-5090; Unger, Elizabeth/0000-0002-2925-5635 NR 25 TC 12 Z9 13 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1741-7015 J9 BMC MED JI BMC Med. PD OCT 12 PY 2009 VL 7 AR 57 DI 10.1186/1741-7015-7-57 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 512HA UT WOS:000271235700001 PM 19818157 ER PT J AU Shuler, CM Fiore, AE Neeman, R Bell, BP Kuhnert, W Watkins, S Kilgour, K Arnold, KE AF Shuler, Carrie M. Fiore, Anthony E. Neeman, Ruth Bell, Beth P. Kuhnert, Wendi Watkins, Sandra Kilgour, Kimberly Arnold, Kathryn E. TI Reduction in hepatitis B virus seroprevalence among US-born children of foreign-born Asian parents-Benefit of universal infant hepatitis B vaccination SO VACCINE LA English DT Article DE Hepatitis B immunizations; Pediatrics ID UNITED-STATES; INFECTION; IMMUNIZATION; EPIDEMIOLOGY; TRANSMISSION; ELIMINATION; PREVENTION; PREVALENCE; REFUGEES; PROGRAM AB We demonstrate that after implementation of recommendations for universal infant hepatitis B vaccination, HBV infection prevalence among children of foreign-born Asian parents in Georgia declined dramatically; horizontal transmission of infection within households has occurred infrequently; and the vast majority of infants and children have received the recommended hepatitis B vaccinations. These results provide evidence of the success of the hepatitis B infant vaccination program and highlight its potential impact on reducing chronic HBV infection morbidity and mortality among U.S. populations at high risk. Published by Elsevier Ltd. C1 [Shuler, Carrie M.; Neeman, Ruth; Arnold, Kathryn E.] Georgia Dept Human Resources, Notifiable Dis Epidemiol Sect, Div Publ Hlth, Atlanta, GA USA. [Shuler, Carrie M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Kuhnert, Wendi] Ctr Dis Control & Prevent, Div Viral Hepatitis, Coordinating Ctr Infect Dis, Hepatatis Lab, Atlanta, GA USA. [Watkins, Sandra; Kilgour, Kimberly] Georgia Dept Human Resources, Georgia Publ Hlth Lab, Div Publ Hlth, Atlanta, GA USA. RP Shuler, CM (reprint author), 2680 NW Thurman St, Portland, OR 97210 USA. EM carrie_dogcat@yahoo.com FU Infectious Disease Society of America Conference FX This work was presented in part at the Infectious Disease Society of America Conference: October 9-12, 2003: San Diego, California. NR 34 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 9 PY 2009 VL 27 IS 43 BP 5942 EP 5947 DI 10.1016/j.vaccine.2009.07.087 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 511MW UT WOS:000271170500005 PM 19679217 ER PT J AU Whittembury, A Ramirez, G Hernandez, H Ropero, AM Waterman, S Ticona, M Brinton, M Uchuya, J Gershman, M Toledo, W Staples, E Campos, C Martinez, M Chang, GJJ Cabezas, C Lanciotti, R Zaki, S Montgomery, JM Monath, T Hayes, E AF Whittembury, Alvaro Ramirez, Gladys Hernandez, Herminio Ropero, Alba Maria Waterman, Steve Ticona, Maria Brinton, Margo Uchuya, Jorge Gershman, Mark Toledo, Washington Staples, Erin Campos, Clarense Martinez, Mario Chang, Gwong-Jen J. Cabezas, Cesar Lanciotti, Robert Zaki, Sherif Montgomery, Joel M. Monath, Thomas Hayes, Edward TI Viscerotropic disease following yellow fever vaccination in Peru SO VACCINE LA English DT Article DE Yellow fever vaccine; Viscerotropic disease; Vaccine safety; Yellow fever; Arbovirus ID SERIOUS ADVERSE EVENTS; WEST-NILE-VIRUS; 17DD VACCINE; INFECTION; FAILURE; VIREMIA; BRAZIL; ASSAYS; DEATH; SPAIN AB Five suspected cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) clustered in space and time following a vaccination campaign in Ica, Peru in 2007. All five people received the same lot of 17DD live attenuated yellow fever vaccine before their illness; four of the five died of confirmed YEL-AVD. The surviving case was classified as probable YEL-AVD. Intensive investigation yielded no abnormalities of the implicated vaccine lot and no common risk factors. This is the first described space-time cluster of yellow fever viscerotropic disease involving more than two cases. Mass yellow fever vaccination should be avoided in areas that present extremely low risk of yellow fever. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Hayes, Edward] Barcelona Ctr Int Hlth Res CRESIB, Barcelona 08017, Spain. [Whittembury, Alvaro; Ramirez, Gladys; Hernandez, Herminio; Ticona, Maria; Uchuya, Jorge; Cabezas, Cesar] Minist Salud, Lima, Peru. [Ropero, Alba Maria] Pan Amer Hlth Org, Washington, DC USA. [Toledo, Washington; Martinez, Mario] Pan Amer Hlth Org, Lima, Peru. [Waterman, Steve; Gershman, Mark; Zaki, Sherif; Montgomery, Joel M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Staples, Erin; Chang, Gwong-Jen J.; Lanciotti, Robert; Hayes, Edward] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Brinton, Margo] Georgia State Univ, Atlanta, GA 30303 USA. [Campos, Clarense] Direcc Reg Salud, Ica, Peru. [Montgomery, Joel M.] US Navy Med Res Detachment, Lima, Peru. [Monath, Thomas] Kleiner Perkins Caufield & Byers, Menlo Pk, CA USA. RP Hayes, E (reprint author), Barcelona Ctr Int Hlth Res CRESIB, Rosello 132, Barcelona 08017, Spain. EM ned.hayes@cresib.cat NR 25 TC 45 Z9 47 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 9 PY 2009 VL 27 IS 43 BP 5974 EP 5981 DI 10.1016/j.vaccine.2009.07.082 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 511MW UT WOS:000271170500009 PM 19679215 ER PT J AU Pandya, GA Holmes, MH Petersen, JM Pradhan, S Karamycheva, SA Wolcott, MJ Molins, C Jones, M Schriefer, ME Fleischmann, RD Peterson, SN AF Pandya, Gagan A. Holmes, Michael H. Petersen, Jeannine M. Pradhan, Sonal Karamycheva, Svetlana A. Wolcott, Mark J. Molins, Claudia Jones, Marcus Schriefer, Martin E. Fleischmann, Robert D. Peterson, Scott N. TI Whole genome single nucleotide polymorphism based phylogeny of Francisella tularensis and its application to the development of a strain typing assay SO BMC MICROBIOLOGY LA English DT Article ID TANDEM REPEAT ANALYSIS; UNITED-STATES; MOLECULAR EPIDEMIOLOGY; BAYESIAN-INFERENCE; TULAREMIA; EVOLUTION; DISCRIMINATION; DIVERSITY; MRBAYES; PCR AB Background: A low genetic diversity in Francisella tularensis has been documented. Current DNA based genotyping methods for typing F. tularensis offer a limited and varying degree of subspecies, clade and strain level discrimination power. Whole genome sequencing is the most accurate and reliable method to identify, type and determine phylogenetic relationships among strains of a species. However, lower cost typing schemes are necessary in order to enable typing of hundreds or even thousands of isolates. Results: We have generated a high-resolution phylogenetic tree from 40 Francisella isolates, including 13 F. tularensis subspecies holarctica (type B) strains, 26 F. tularensis subsp. tularensis (type A) strains and a single F. novicida strain. The tree was generated from global multi-strain single nucleotide polymorphism (SNP) data collected using a set of six Affymetrix GeneChip (R) resequencing arrays with the non-repetitive portion of LVS (type B) as the reference sequence complemented with unique sequences of SCHU S4 (type A). Global SNP based phylogenetic clustering was able to resolve all non-related strains. The phylogenetic tree was used to guide the selection of informative SNPs specific to major nodes in the tree for development of a genotyping assay for identification of F. tularensis subspecies and clades. We designed and validated an assay that uses these SNPs to accurately genotype 39 additional F. tularensis strains as type A (A1, A2, A1a or A1b) or type B (B1 or B2). Conclusion: Whole-genome SNP based clustering was shown to accurately identify SNPs for differentiation of F. tularensis subspecies and clades, emphasizing the potential power and utility of this methodology for selecting SNPs for typing of F. tularensis to the strain level. Additionally, whole genome sequence based SNP information gained from a representative population of strains may be used to perform evolutionary or phylogenetic comparisons of strains, or selection of unique strains for whole-genome sequencing projects. C1 [Pandya, Gagan A.; Holmes, Michael H.; Pradhan, Sonal; Karamycheva, Svetlana A.; Jones, Marcus; Fleischmann, Robert D.; Peterson, Scott N.] J Craig Venter Inst, Pathogen Funct Genom Resource Ctr, Rockville, MD 20850 USA. [Petersen, Jeannine M.; Molins, Claudia; Schriefer, Martin E.] CDC, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Wolcott, Mark J.] USAMRIID, Ft Detrick, MD 21702 USA. RP Peterson, SN (reprint author), J Craig Venter Inst, Pathogen Funct Genom Resource Ctr, Rockville, MD 20850 USA. EM gpandya@jcvi.org; mholmes@jcvi.org; nzp0@cdc.gov; sonal.k.pradhan@gmail.com; Svetlana@jcvi.org; mark.j.wolcott@us.army.mil; ard5@cdc.gov; mjones@jcvi.org; mms7@cdc.gov; rdfleisc@jcvi.org; scottp@jcvi.org FU NIAID [N01-AI-15447] FX We thank Dr. Luther Lindler of Global Emerging Infections Surveillance and Response System of Department of Defense for providing us with genomic DNA samples of reference F. tularensis LVS and SCHU S4 strains. Cultures or materials used in this study were from the Centers for Disease Control and Prevention or from the Department of Defense United Culture Collection (UCC) as maintained under the Joint Program Executive Office-Chemical and Biological Defense, Medical Identification & Treatment Systems, Critical Reagents Program (JPEO-CBD, CBMS, MITS, CRP). The technical assistance of David Bedwell is gratefully acknowledged. We also thank Timothy Minogue, Kathy Ong, Erik Snesrud and Ian Broverman for helping us with the optimization and validation of PCR diagnostic assay conditions. We acknowledge Dr. Ben Beard and Kristy Kubota for providing critical scientific input. This work was supported by the NIAID contract No. N01-AI-15447 to Pathogen Functional Genomics Resource Center. NR 28 TC 32 Z9 33 U1 1 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD OCT 7 PY 2009 VL 9 AR 213 DI 10.1186/1471-2180-9-213 PG 17 WC Microbiology SC Microbiology GA 512YL UT WOS:000271288300002 PM 19811647 ER PT J AU Bakken, J Neitzel, D Taylor, L Civen, R Plawner, LL McKiernan, S Duchin, JS Baer, R Marsden-Haug, N Thamthitiwat, S Baggett, HC Campbell, GL Griggs, A Panella, AJ Laven, J Kosoy, O Lanciotti, RS Staples, JE Fischer, M Duffy, M AF Bakken, J. Neitzel, D. Taylor, L. Civen, R. Plawner, L. L. McKiernan, S. Duchin, J. S. Baer, R. Marsden-Haug, N. Thamthitiwat, S. Baggett, H. C. Campbell, G. L. Griggs, A. Panella, A. J. Laven, J. Kosoy, O. Lanciotti, R. S. Staples, J. E. Fischer, M. Duffy, M. TI Japanese Encephalitis Among Three U.S. Travelers Returning From Asia, 2003-2008 (Reprinted from MMWR, vol 58, pg 737-740, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Bakken, J.] St Lukes Infect Dis Associates, Duluth, MN USA. [Neitzel, D.] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Taylor, L.; Civen, R.] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [Plawner, L. L.] Seattle Childrens, Seattle, WA USA. [Baer, R.; Marsden-Haug, N.] Washington State Dept Health, Washington, DC USA. [Duffy, M.] CDC, Atlanta, GA 30333 USA. RP Bakken, J (reprint author), St Lukes Infect Dis Associates, Duluth, MN USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 7 PY 2009 VL 302 IS 13 BP 1410 EP 1412 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 503CL UT WOS:000270509600005 ER PT J AU Malhotra, U Rakita, R Fernandez, F Harris, G Arguin, P Bronzan, R Slutsker, L Green, M Townes, D AF Malhotra, U. Rakita, R. Fernandez, F. Harris, G. Arguin, P. Bronzan, R. Slutsker, L. Green, M. Townes, D. TI Hepatitis Temporally Associated With an Herbal Supplement Containing Artemisinin-Washington, 2008 (Reprinted from MMWR, vol 58, pg 854-856, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Malhotra, U.; Rakita, R.] Virginia Mason Med Ctr, Infect Dis Sect, Seattle, WA 98101 USA. [Fernandez, F.; Harris, G.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Townes, D.] CDC, Atlanta, GA 30333 USA. RP Malhotra, U (reprint author), Virginia Mason Med Ctr, Infect Dis Sect, Seattle, WA 98101 USA. RI Fernandez, Facundo/B-7015-2008 NR 10 TC 2 Z9 2 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 7 PY 2009 VL 302 IS 13 BP 1412 EP + PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 503CL UT WOS:000270509600006 ER PT J AU Khazeni, N Bravata, DM Holty, JEC Uyeki, TM Stave, CD Gould, MK AF Khazeni, Nayer Bravata, Dena M. Holty, Jon-Erik C. Uyeki, Timothy M. Stave, Christopher D. Gould, Michael K. TI Systematic Review: Safety and Efficacy of Extended-Duration Antiviral Chemoprophylaxis Against Pandemic and Seasonal Influenza SO ANNALS OF INTERNAL MEDICINE LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; LONG-TERM USE; A H1N1 VIRUS; RESISTANT INFLUENZA; IMMUNE-RESPONSE; TRANSPLANT RECIPIENTS; PATIENT COMPLIANCE; INHALED ZANAMIVIR; PUBLICATION BIAS; CLINICAL-TRIALS AB Background: Neuraminidase inhibitors (NAIs) are stockpiled internationally for extended use in an influenza pandemic. Purpose: To evaluate the safety and efficacy of extended-duration (>4 weeks) NAI chemoprophylaxis against influenza. Data Sources: Studies published in any language through 11 June 2009 identified by searching 10 electronic databases and 3 trial registries. Study Selection: Randomized, placebo-controlled, double-blind human trials of extended-duration NAI chemoprophylaxis that reported outcomes of laboratory-confirmed influenza or adverse events. Data Extraction: 2 reviewers independently assessed study quality and abstracted information from eligible studies. Data Synthesis: Of 1876 potentially relevant citations, 7 trials involving 7021 unique participants met inclusion criteria. Data were pooled by using random-effects models. Chemoprophylaxis with NAIs decreased the frequency of symptomatic influenza (relative risk [RR], 0.26 [95% CI, 0.18 to 0.37]; risk difference [RD], -3.9 percentage points [CI, -5.8 to -1.9 percentage points]) but not asymptomatic influenza (RR, 1.03 [CI, 0.81 to 1.30]; RD, -0.4 percentage point [CI, -1.6 to 0.9 percentage point]). Adverse effects were not increased overall among NAI recipients (RR, 1.01 [CI, 0.94 to 1.08]; RD, 0.1 percentage point [CI, -0.2 to 0.4 percentage point]), but nausea and vomiting were more common among those who took oseltamivir (RR, 1.48 [CI, 1.86 to 2.33]; RD, 1.7 percentage points [CI, 0.6 to 2.9 percentage points]). Prevention of influenza did not statistically significantly differ between zanamivir and oseltamivir. Limitations: All trials were industry-sponsored. No study was powered to detect rare adverse events, and none included diverse racial groups, children, immunocompromised patients, or individuals who received live attenuated influenza virus vaccine. Conclusion: Extended-duration zanamivir and oseltamivir chemoprophylaxis seems to be highly efficacious for preventing symptomatic influenza among immunocompetent white and Japanese adults. Extended-duration oseltamivir is associated with increased nausea and vomiting. Safety and efficacy in several subpopulations that might receive extended-duration influenza chemoprophylaxis are unknown. C1 [Khazeni, Nayer] Stanford Univ, Med Ctr, Div Pulm & Crit Care Med, Ctr Hlth Policy, Stanford, CA 94305 USA. Stanford Sleep Disorders Ctr, Ctr Primary Care & Outcomes Res, Stanford, CA USA. Lane Med Lib, Stanford, CA USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA. RP Khazeni, N (reprint author), Stanford Univ, Med Ctr, Div Pulm & Crit Care Med, Ctr Hlth Policy, 300 Pasteur Dr,H3143, Stanford, CA 94305 USA. FU Agency for Healthcare Research and Quality [1 F32 HS018003-01A1] FX By the Agency for Healthcare Research and Quality (1 F32 HS018003-01A1, Dr. Khazeni) and resources and the use of facilities at the Veterans Affairs Palo Alto Health Care System (Dr. Gould). NR 73 TC 28 Z9 29 U1 2 U2 8 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD OCT 6 PY 2009 VL 151 IS 7 BP 464 EP W159 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA 502OT UT WOS:000270470500004 PM 19652173 ER PT J AU Decker, MJ Tabassum, H Lin, JMS Reeves, WC AF Decker, Michael J. Tabassum, Humyra Lin, Jin-Mann S. Reeves, William C. TI Electroencephalographic correlates of Chronic Fatigue Syndrome SO BEHAVIORAL AND BRAIN FUNCTIONS LA English DT Article ID AUTONOMIC NERVOUS-SYSTEM; SLOW-WAVE SLEEP; TWINS DISCORDANT; ALPHA-RHYTHM; EEG; FIBROMYALGIA; GENERATION; SYMPTOMS; HUMANS; MEMORY AB Background: Unremitting fatigue and unrefreshing sleep, hallmark traits of Chronic Fatigue Syndrome (CFS), are also pathognomonic of sleep disorders. Yet, no reproducible perturbations of sleep architecture, multiple sleep latency times or Epworth Sleepiness Scores are found to be associated consistently with CFS. This led us to hypothesize that sleep homeostasis, rather than sleep architecture, may be perturbed in CFS. To probe this hypothesis, we measured and compared EEG frequencies associated with restorative sleep between persons with CFS and matched controls, both derived from a population-based sample. Methods: We evaluated overnight polysomnography (PSG) in 35 CFS and 40 control subjects. PSG records were manually scored and epochs containing artifact removed. Fast Fourier Transformation was utilized to deconstruct individual EEG signals into primary frequency bands of alpha, delta, theta, sigma, and beta frequency domains. The spectral power of each frequency domain for each sleep state was compared between persons with CFS and matched controls. Results: In persons with CFS, delta power was diminished during slow wave sleep, but elevated during both stage 1 and REM. Alpha power was reduced during stage 2, slow wave, and REM sleep. Those with CFS also had significantly lower theta, sigma, and beta spectral power during stage 2, Slow Wave Sleep, and REM. Discussion: Employing quantitative EEG analysis we demonstrate reduced spectral power of cortical delta activity during SWS. We also establish reduced spectral power of cortical alpha activity, with the greatest reduction occurring during REM sleep. Reductions in theta, beta, and sigma spectral power were also apparent. Conclusion: Unremitting fatigue and unrefreshing sleep, the waking manifestations of CFS, may be the consequence of impaired sleep homeostasis rather than a primary sleep disorder. C1 [Decker, Michael J.; Tabassum, Humyra; Lin, Jin-Mann S.; Reeves, William C.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot, Atlanta, GA 30333 USA. RP Decker, MJ (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot, 1600 Clifton Rd,Mail Stop A-15, Atlanta, GA 30333 USA. EM mdecker@cdc.gov; Hey9@cdc.gov; dwe3@cdc.gov; wcr1@cdc.gov NR 41 TC 15 Z9 15 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1744-9081 J9 BEHAV BRAIN FUNCT JI Behav. Brain Funct. PD OCT 6 PY 2009 VL 5 AR 43 DI 10.1186/1744-9081-5-43 PG 8 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA 510BK UT WOS:000271062800001 PM 19807920 ER PT J AU Jackson, LA Yu, O Belongia, EA Hambidge, SJ Nelson, J Baxter, R Naleway, A Gay, C Nordin, J Baggs, J Iskander, J AF Jackson, Lisa A. Yu, Onchee Belongia, Edward A. Hambidge, Simon J. Nelson, Jennifer Baxter, Roger Naleway, Allison Gay, Charlene Nordin, James Baggs, James Iskander, John TI Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study SO BMC INFECTIOUS DISEASES LA English DT Article ID ACELLULAR PERTUSSIS-VACCINE; IMMUNIZATION PRACTICES ACIP; INJECTION SITE REACTIONS; ADVISORY-COMMITTEE; PREVENTING TETANUS; RECOMMENDATIONS; COMBINATION; ANAPHYLAXIS; CHILDREN; PROJECT AB Background: Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods: To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results: Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion: Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. C1 [Jackson, Lisa A.; Yu, Onchee; Nelson, Jennifer] Grp Hlth Res Inst, Seattle, WA USA. [Belongia, Edward A.] Marshfield Clin Fdn Med Res & Educ, Epidemiol Res Ctr, Marshfield, WI 54449 USA. [Hambidge, Simon J.] Kaiser Permanente Inst Hlth Res, Denver, CO USA. [Hambidge, Simon J.] Denver Hlth Community Hlth Serv, Denver, CO USA. [Nelson, Jennifer] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Baxter, Roger] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Naleway, Allison] Kaiser Permanente NW, Portland, OR USA. [Gay, Charlene] Harvard Pilgrim Hlth Care, Dept Ambulatory Care & Prevent, Boston, MA USA. [Gay, Charlene] Harvard Univ, Sch Med, Boston, MA USA. [Nordin, James] HealthPartners, Minneapolis, MN USA. [Baggs, James; Iskander, John] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Jackson, LA (reprint author), Grp Hlth Res Inst, Seattle, WA USA. EM jackson.l@ghc.org; yu.o@ghc.org; belongia.edward@mcrf.mfldclin.edu; simon.hambidge@kp.org; nelson.jl@ghc.org; roger.baxter@kp.org; allison.naleway@kpchr.org; charlene_gay@harvardpilgrim.org; james.d.nordin@healthpartners.com; izb7@cdc.gov; jxi0@cdc.gov OI Naleway, Allison/0000-0001-5747-4643; Baggs, James/0000-0003-0757-4683 FU Centers for Disease Control and Prevention (CDC) [200-2002-00732] FX This study was funded through a subcontract with America's Health Insurance Plans (AHIP) under contract 200-2002-00732 from the Centers for Disease Control and Prevention (CDC). NR 19 TC 13 Z9 13 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD OCT 5 PY 2009 VL 9 AR 165 DI 10.1186/1471-2334-9-165 PG 7 WC Infectious Diseases SC Infectious Diseases GA 512FV UT WOS:000271232600001 PM 19804643 ER PT J AU Besser, RE AF Besser, Richard E. TI INTELLECTUAL PROPERTY Drug Metabolite Patents Prompt Legal Battle (vol 325, pg 665, 2009) SO SCIENCE LA English DT Correction C1 [Besser, Richard E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD OCT 2 PY 2009 VL 326 IS 5949 BP 46 EP 46 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 501CA UT WOS:000270355600016 ER PT J AU Parry, CDH Dewing, S Petersen, P Carney, T Needle, R Kroeger, K Treger, L AF Parry, Charles D. H. Dewing, Sarah Petersen, Petal Carney, Tara Needle, Richard Kroeger, Karen Treger, Latasha TI Rapid Assessment of HIV Risk Behavior in Drug Using Sex Workers in Three Cities in South Africa SO AIDS AND BEHAVIOR LA English DT Article DE South Africa; Drug use; HIV transmission; Risk factors; Sex work ID SUBSTANCE USE; VIOLENCE; PROSTITUTION; JOHANNESBURG; PREVENTION; INFECTION; BARRIERS; ALCOHOL; NIGERIA AB A rapid assessment was undertaken with drug using commercial sex workers (CSWs) to investigate practices putting them at risk for contracting HIV. It included key informant (KI) (N = 67) and focus group (N = 10) interviews in locations with a high prevalence of drug use in Cape Town, Durban and Pretoria, South Africa. HIV testing of KIs was conducted. Cocaine, Ecstasy, heroin and methaqualone are used by CSWs prior to, during and after sex. Drugs enhance the sexual experience and prolong sex sessions. Interviews revealed inconsistent condom use among CSWs together with other risky sexual practices such as needle sharing. Among CSWs who agreed to HIV testing, 34% tested positive. Barriers to accessing drug treatment and HIV treatment and preventive services were identified. Interventions recognizing the role of drug abuse in HIV transmission should be prioritized, and issues of access to services, stigma and power relations must be considered. C1 [Parry, Charles D. H.; Dewing, Sarah; Petersen, Petal; Carney, Tara] MRC, Alcohol & Drug Abuse Res Unit, ZA-7505 Tygerberg, Cape Town, South Africa. [Parry, Charles D. H.] Univ Stellenbosch, Dept Psychiat, ZA-7505 Tygerberg, South Africa. [Needle, Richard; Kroeger, Karen] US Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, Global AIDS Program, Atlanta, GA 30333 USA. [Treger, Latasha] Global AIDS Program, CDC, ZA-0001 Pretoria, South Africa. RP Parry, CDH (reprint author), MRC, Alcohol & Drug Abuse Res Unit, POB 19070, ZA-7505 Tygerberg, Cape Town, South Africa. EM cparry@mrc.ac.za RI Parry, Charles/A-2906-2009 OI Parry, Charles/0000-0001-9787-2785 NR 40 TC 17 Z9 18 U1 1 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS behav. PD OCT PY 2009 VL 13 IS 5 BP 849 EP 859 DI 10.1007/s10461-008-9367-3 PG 11 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 502AI UT WOS:000270425800003 PM 18324470 ER PT J AU Kim, AA Malele, F Kaiser, R Mama, N Kinkela, T Mantshumba, JC Hynes, M De Jesus, S Musema, G Kayembe, PK Reed, KH Diaz, T AF Kim, Andrea A. Malele, Faustin Kaiser, Reinhard Mama, Nicaise Kinkela, Timothee Mantshumba, Jean-Caurent Hynes, Michelle De Jesus, Stacy Musema, Godefoid Kayembe, Patrick K. Reed, Karen Hawkins Diaz, Theresa TI HIV Infection Among Internally Displaced Women and Women Residing in River Populations Along the Congo River, Democratic Republic of Congo SO AIDS AND BEHAVIOR LA English DT Article DE HIV; Sexually transmitted infections; Displacement; Conflict ID PREVALENCE AB We conducted a reproductive health assessment among women aged 15-49 years residing in an internally displaced persons (IDP) camp and surrounding river populations in the Democratic Republic of Congo. After providing informed consent, participants were administered a behavioral questionnaire on demographics, sexual risk, reproductive health behavior, and a history of gender based violence. Participants provided a blood specimen for HIV and syphilis testing and were referred to HIV counseling and testing services established for this study to learn their HIV status. HIV prevalence was significantly higher among women in the IDP population compared to women in the river population. Sexually transmitted infection symptoms in the past 12 months and a history of sexual violence during the conflict were associated with HIV infection the river and IDP population, respectively. Targeted prevention, care, and treatment services are urgently needed for the IDP population and surrounding host communities during displacement and resettlement. C1 [Kim, Andrea A.; Diaz, Theresa] US Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Malele, Faustin; Reed, Karen Hawkins] US Ctr Dis Control & Prevent, Global AIDS Program Democrat Republ Congo, Kinshasa, Zaire. [Kaiser, Reinhard] US Ctr Dis Control & Prevent, Int Emergency & Refugee Hlth Branch, Coordinating Ctr Environm Hlth & Injury Prevent, Atlanta, GA 30333 USA. [Mama, Nicaise; Kinkela, Timothee; Mantshumba, Jean-Caurent] Minist Hlth, Kinshasa, Zaire. [Hynes, Michelle; De Jesus, Stacy] US Ctr Dis Control & Prevent, Div Reprod Hlth, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. [Musema, Godefoid; Kayembe, Patrick K.] Kinshasa Sch Publ Hlth, Kinshasa, Zaire. RP Kim, AA (reprint author), US Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Hepatitis STD & TB Prevent, 1600 Clifton Rd,ME E-30, Atlanta, GA 30333 USA. EM aakim@cdc.gov OI Kayembe Kalambayi, Patrick/0000-0002-5693-2144 NR 12 TC 12 Z9 12 U1 0 U2 17 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS behav. PD OCT PY 2009 VL 13 IS 5 BP 914 EP 920 DI 10.1007/s10461-009-9536-z PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 502AI UT WOS:000270425800010 PM 19319674 ER PT J AU Dean, HD AF Dean, Hazel D. TI FOREWORD: HIV/AIDS PREVENTION IN THE HISPANIC/LATINO COMMUNITY SO AIDS EDUCATION AND PREVENTION LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Coordinating Ctr Infect Dis, Off Director, Atlanta, GA 30333 USA. RP Dean, HD (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Coordinating Ctr Infect Dis, Off Director, Mail Stop E-07,1600 Clifton Rd, Atlanta, GA 30333 USA. EM HDean@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 1 EP 2 PG 2 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500001 PM 19824829 ER PT J AU Stallworth, JM Herbst, JH Alvarez, ME Romaguera, RA Amaro, H Dean, HD AF Stallworth, JoAna M. Herbst, Jeffrey H. Alvarez, Maria E. Romaguera, Raul A. Amaro, Hortensia Dean, Hazel D. TI INTRODUCTION SO AIDS EDUCATION AND PREVENTION LA English DT Editorial Material ID UNITED-STATES; INFECTION C1 [Stallworth, JoAna M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Capac Bldg Branch, NCHHSTP, Atlanta, GA 30333 USA. [Romaguera, Raul A.] CDC, Div STD Prevent, Atlanta, GA 30333 USA. [Amaro, Hortensia] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA. [Amaro, Hortensia] Northeastern Univ, Inst Urban Hlth Res, Boston, MA 02115 USA. [Dean, Hazel D.] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Stallworth, JM (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Capac Bldg Branch, NCHHSTP, 1600 Clifton Rd NE,Mailstop E-40, Atlanta, GA 30333 USA. EM jstallworth@cdc.gov RI Amaro, Hortensia/G-8083-2011 NR 10 TC 0 Z9 0 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 3 EP 6 PG 4 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500002 PM 19824830 ER PT J AU Alvarez, ME Jakhmola, P Painter, TM Taillepierre, JD Romaguera, RA Herbst, JH Wolitski, RJ AF Alvarez, Maria E. Jakhmola, Priya Painter, Thomas M. Taillepierre, Julio Dicent Romaguera, Raul A. Herbst, Jeffrey H. Wolitski, Richard J. TI SUMMARY OF COMMENTS AND RECOMMENDATIONS FROM THE CDC CONSULTATION ON THE HIV/AIDS EPIDEMIC AND PREVENTION IN THE HISPANIC/LATINO COMMUNITY SO AIDS EDUCATION AND PREVENTION LA English DT Article ID HIV RISK BEHAVIORS; UNITED-STATES; PUERTO-RICO; LATINO MEN; DRUG-USERS; INTERVENTION; SEX; ACCULTURATION; INFECTION; AMERICAN AB In April 2008, the U.S. Centers for Disease Control and Prevention (CDC) hosted a national consultation meeting of academic researchers, public health officials, service providers, and community leaders to examine the HIV/AIDS epidemic and prevention needs of Hispanics/Latinos in the United States and its territories. The consultation engaged key stakeholders to review available information on HIV-related behavioral research and prevention efforts, describe gaps in current HIV prevention programs and research on Hispanics/Latinos, and identify community and societal-level factors that can increase vulnerability of Hispanics/Latinos for acquiring or transmitting HIV infection. Recommendations were also made to CDC for future collaboration with the Hispanic/Latino community in areas of HIV prevention research and prevention programs. This article summarizes participants' recommendations for HIV prevention research, program and capacity building, policy and planning, and partnerships and communication. These recommendations will be used by CDC to inform the development of a National Plan of Action for HIV/AIDS prevention among Hispanics/Latinos, and can provide a framework for use by other federal and non-federal agencies, academic researchers, community-based organizations, and policymakers as they seek to curtail the HIV epidemic among Hispanics/Latinos. C1 [Alvarez, Maria E.] CDC, NCHHSTP, Off Director, Atlanta, GA 30333 USA. CDC, NCHHSTP, Capac Bldg Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Alvarez, ME (reprint author), CDC, NCHHSTP, Off Director, 1600 Clifton Rd NE,Mailstop E-40, Atlanta, GA 30333 USA. EM malvarez@cdc.gov NR 40 TC 9 Z9 9 U1 3 U2 6 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 EI 1943-2755 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 SU B BP 7 EP 18 PG 12 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500003 PM 19824831 ER PT J AU Espinoza, L Hall, HI Hu, XH AF Espinoza, Lorena Hall, H. Irene Hu, Xiaohong TI INCREASES IN HIV DIAGNOSES AT THE US-MEXICO BORDER, 2003-2006 SO AIDS EDUCATION AND PREVENTION LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; AIDS; TRENDS; EPIDEMIC; RISK; SEX; MEN; CONSUMPTION; PROGRESSION AB The population at the U.S.-Mexico border has experienced growth, more than double the U.S. national average. Movements of populations in this region have contributed to increased incidence of certain infectious diseases. We used information on persons diagnosed with HIV during 2003 to 2006 and aged 1.3 years or older (n = 4,279) reported to the Centers for Disease Control and Prevention for 45 U.S. border counties. We estimated the annual percent change and rates with Poisson regression. Overall, 47% of persons diagnosed with HIV in the border region were Hispanic; 39% nonHispanic white; and 10% nonHispanic black. During 2003 to 2006, HIV diagnoses increased 7.8% per year. Increases were observed among males, particularly among men who have sex with men. Among females, HIV diagnoses remained stable but decreased among females in nonborder regions. The number of HIV diagnoses at the border has increased. To decrease incidence of HIV disease it is necessary to develop prevention and education programs specific to this region. C1 [Espinoza, Lorena; Hall, H. Irene; Hu, Xiaohong] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Espinoza, L (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,Mailstop E-47, Atlanta, GA 30333 USA. EM LEspinoza@cdc.gov NR 48 TC 14 Z9 14 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 19 EP 33 PG 15 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500004 PM 19824832 ER PT J AU Guilamo-Ramos, V Bouris, A Jaccard, J Lesesne, C Ballan, M AF Guilamo-Ramos, Vincent Bouris, Alida Jaccard, James Lesesne, Catherine Ballan, Michelle TI FAMILIAL AND CULTURAL INFLUENCES ON SEXUAL RISK BEHAVIORS AMONG MEXICAN, PUERTO RICAN, AND DOMINICAN YOUTH SO AIDS EDUCATION AND PREVENTION LA English DT Article ID UNITED-STATES; LATINO YOUTH; ACCULTURATION; HEALTH; ADOLESCENTS; HIV; AMERICAN; HISPANICS; MOTHERS; CHILD AB The present study examined the relationship among acculturation, familismo, and HIV-related adolescent sexual risk behavior. Data were collected from Latino mother-adolescent dyads to permit parent and adolescent analyses of familismo for predicting oral, vaginal, and anal sexual behaviors. A random sample of 702 Latino eighth-grade students and their mothers was recruited from New York City. The sample included Mexicans (n = 203), Puerto Ricans (n = 239), and Dominicans (n = 260). Acculturation was unrelated to sexual behavior, but adolescent familismo was related to girls' but not boys' sexual behavior. The most important facet of familismo was subjugation to the family, which was negatively associated with girls' sexual behavior. The implications for HIV prevention programs for Latino youth are discussed. C1 [Guilamo-Ramos, Vincent; Ballan, Michelle] Columbia Univ, Sch Social Work, New York, NY 10027 USA. [Bouris, Alida] Univ Chicago, Sch Social Serv Adm, Chicago, IL 60637 USA. [Jaccard, James] Florida Int Univ, Dept Psychol, Miami, FL 33199 USA. [Lesesne, Catherine] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Guilamo-Ramos, V (reprint author), Columbia Univ, Sch Social Work, 1255 Amsterdam Ave, New York, NY 10027 USA. EM rg650@columbia.edu FU NCCDPHP CDC HHS [1 U01 DP000175] NR 50 TC 27 Z9 27 U1 2 U2 10 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 61 EP 79 PG 19 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500007 PM 19824835 ER PT J AU Rhodes, SD Hergenrather, KC Bloom, FR Leichliter, JS Montano, J AF Rhodes, Scott D. Hergenrather, Kenneth C. Bloom, Fred R. Leichliter, Jami S. Montano, Jaime TI OUTCOMES FROM A COMMUNITY BASED, PARTICIPATORY LAY HEALTH ADVISER HIV/STD PREVENTION INTERVENTION FOR RECENTLY ARRIVED IMMIGRANT LATINO MEN IN RURAL NORTH CAROLINA SO AIDS EDUCATION AND PREVENTION LA English DT Article ID HIV AB Latinos in the United States are at increased risk for HIV and sexually transmitted disease (STD) infection. We evaluated the efficacy of a pilot lay health adviser (LHA) intervention designed to increase condom use and HIV testing among Latino men. Fifteen LHAs (mean age = 35.6; range 23-60 years) from 15 Latino soccer teams were trained and worked with their teammates for 18 months. Another 15 teams served as the control group. Data were collected at baseline and at 18 months post-LHA training from a random sample of teammates from intervention and control teams. Data were collected from 222 men (mean age = 29 years) who participated in one of the 30 teams. Relative to the control condition, participants in the intervention reported more consistent condom use in the 30 days preceding follow-up (unadjusted analysis, intervention, 65.6% vs. control, 41.3%; p < .001). Participants in the intervention were more likely to report condom use (adjusted odds ratio [AOR] = 2.3; confidence interval [CI = 1.2-4.3) and HIV testing (AOR = 2.5; CI - 1.5-4.3). LHA interventions for Latino men that are developed in partnership with community members, rely on male-centered intrapersonal networks, and are culturally congruent can enhance preventive behaviors and may reduce HIV infection. C1 [Rhodes, Scott D.] Wake Forest Univ Hlth Sci, Dept Social Sci & Hlth Policy, Dept Internal Med, Winston Salem, NC USA. [Rhodes, Scott D.] Wake Forest Univ Hlth Sci, Maya Angelou Ctr Hlth Equ, Winston Salem, NC USA. [Hergenrather, Kenneth C.] George Washington Univ, Dept Counseling Human Org Studies, Washington, DC USA. [Bloom, Fred R.; Leichliter, Jami S.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Montano, Jaime] Chatham Social Hlth Council, Siler City, NC USA. RP Rhodes, SD (reprint author), Wake Forest Univ, Dept Social Sci & Hlth Policy, Div Publ Hlth Sci, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM srhodes@wfubmc.edu FU NIMHD NIH HHS [R24 MD002774, R24 MD002774-01] NR 13 TC 30 Z9 30 U1 1 U2 6 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 103 EP 108 PG 6 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500010 PM 19824838 ER PT J AU Stallworth, JM Andia, JF Burgess, R Alvarez, ME Collins, C AF Stallworth, JoAna M. Andia, Jonny F. Burgess, Rashad Alvarez, Maria E. Collins, Charles TI DIFFUSION OF EFFECTIVE BEHAVIORAL INTERVENTIONS AND HISPANIC/LATINO POPULATIONS SO AIDS EDUCATION AND PREVENTION LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV PREVENTION INTERVENTION; RISK-REDUCTION INTERVENTION; DEMONSTRATION PROJECTS; HETEROSEXUAL COUPLES; PUERTO-RICO; EFFICACY; TRIAL; SEX AB The national HIV/AIDS prevention program, the Diffusion of Effective Behavioral Interventions (DEBI), is described in the context of addressing Hispanics/Latinos at risk for HIV/AIDS in the United States and Puerto Rico. The eight-step DEBI model is referenced in terms of the interventions and Division of HIV/AIDS Prevention/Capacity Building Branch (DHAP/CBB) Latino Diffusion Team activities. A summary of activities and examples addressing diffusion needs for the diverse Hispanic/Latino populations is discussed. Challenges and successes in diffusion and partner collaborations are also presented, with comment on future directions such as translations and trainings to serve the needs of the Hispanic/Latino-serving community-based organizations and their communities. C1 [Stallworth, JoAna M.] Ctr Dis Control & Prevent, Capac Bldg Branch, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA. RP Stallworth, JM (reprint author), Ctr Dis Control & Prevent, Capac Bldg Branch, Div HIV AIDS Prevent, NCHHSTP, 1600 Clifton Rd NE,Mailstop E-40, Atlanta, GA 30333 USA. EM jstallworth@cdc.gov NR 39 TC 4 Z9 4 U1 8 U2 11 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 152 EP 163 PG 12 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500014 PM 19824842 ER PT J AU Mueller, TE Castaneda, CA Sainer, S Martinez, D Herbst, JH Wilkes, AL Villarruel, AM AF Mueller, Trisha E. Castaneda, Charlene Angel Sainer, Shannon Martinez, Donna Herbst, Jeffrey H. Wilkes, Aisha L. Villarruel, Antonia M. TI THE IMPLEMENTATION OF A CULTURALLY BASED HIV SEXUAL RISK REDUCTION PROGRAM FOR LATINO YOUTH IN A DENVER AREA HIGH SCHOOL SO AIDS EDUCATION AND PREVENTION LA English DT Article ID BEHAVIORAL INTERVENTIONS; ADOLESCENTS; TRIAL AB In the United States, Latino youth experience disproportionately higher rates of teen pregnancy and sexually transmitted infections (STIs) than non-Latino Whites. As a result, organizations serving Latino youth seek culturally appropriate evidence-based prevention programs that promote sexual abstinence and condom use. !Cuidate! is an efficacious HIV sexual risk reduction program for Latino youth aged 13-18. The program incorporates cultural beliefs that are common among Latino youth and associated with sexual risk behavior, and uses these beliefs to frame abstinence and condom use as culturally accepted and effective ways to prevent unintended pregnancy and STIs, including HIV/AIDS. !Cuidate! has been successfully delivered in community agencies and after-school programs but has not been integrated into an existing school curriculum. This brief case study describes efforts to implement !Cuidate! in a predominantly Latino urban high school in Denver. Ninety-three youth participated in the program from October 2007 to May 2008. !Cuidate! was adapted to accommodate the typical class period by delivering program content over a larger number of sessions and extending the total amount of time of the program to allow for additional activities. Major challenges of program implementation included student recruitment and the "opt in" policy for participation. Despite these challenges, !Cuidate! was implemented with minor adaptations in a school setting. C1 [Mueller, Trisha E.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Castaneda, Charlene Angel; Martinez, Donna] DAYS, Denver, CO USA. [Sainer, Shannon] COAPPP, Denver, CO USA. [Villarruel, Antonia M.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. RP Mueller, TE (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy MS K-22, Atlanta, GA 30341 USA. EM tmueller@cdc.gov FU NCHHSTP CDC HHS [1H62PS000581]; PHS HHS [U58CCU825010] NR 17 TC 6 Z9 7 U1 0 U2 8 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 164 EP 170 PG 7 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500015 PM 19824843 ER PT J AU Pemberton, G Andia, J Robles, R Collins, C Colon-Cartagena, N Del Pilar, OP Vega, TS AF Pemberton, Gisele Andia, Jonny Robles, Rafaela Collins, Charles Colon-Cartagena, Nelson Del Pilar, Omar Perez Vega, Teresa Soto TI FROM RESEARCH TO COMMUNITY BASED PRACTICE-WORKING WITH LATINO RESEARCHERS TO TRANSLATE AND DIFFUSE A CULTURALLY RELEVANT EVIDENCE-BASED INTERVENTION: THE MODELO DE INTERVENCION PSICOMEDICA (MIP) EXPERIENCE SO AIDS EDUCATION AND PREVENTION LA English DT Article ID INJECTION-DRUG USERS; EFFECTIVE BEHAVIORAL INTERVENTIONS; PUERTO-RICO; NEW-YORK; TECHNOLOGY-TRANSFER; RISK BEHAVIORS; EAST HARLEM; HIV; PREVENTION; SCIENCE AB Efforts to translate, package, and diffuse HIV/AIDS research into practice have gained momentum with the Centers for Disease Control and Prevention's (CDC's) launch of three projects: the Prevention Research Synthesis Project, which identifies evidence-based interventions studies; the Replicating Effective Programs Project, which supports the translation of evidence-based interventions into materials suitable for use in local prevention programs; and the Diffusion of Effective Behavioral Interventions Project, which moves behavioral interventions into full-scale practice across the United States. This article describes the CDC's fast-track process of translation, packaging, and diffusion of an HIV intervention for Hispanic/Latino injection drug users, the Modelo de Intervencion Psicomedica conducted by the Diffusion of Effective Behavioral Interventions Project in collaboration with a CBA organization and the original researchers. C1 [Andia, Jonny] Ctr Dis Control & Prevent, Behav Sci Sci Applicat Team, Capac Bldg Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Pemberton, Gisele; Vega, Teresa Soto] PROCEED Inc, Elizabeth, NJ USA. [Robles, Rafaela; Del Pilar, Omar Perez] Univ Cent Caribe, Escuela Med, Puerto Real, Spain. RP Andia, J (reprint author), Ctr Dis Control & Prevent, Behav Sci Sci Applicat Team, Capac Bldg Branch, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS E-40, Atlanta, GA 30333 USA. EM efn4@cdc.gov FU PHS HHS [04019] NR 46 TC 6 Z9 6 U1 1 U2 1 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD OCT PY 2009 VL 21 IS 5 BP 171 EP 185 PG 15 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 515AD UT WOS:000271437500016 PM 19824844 ER PT J AU Minnis, AM Steiner, MJ Gallo, MF Warner, L Hobbs, MM van der Straten, A Chipato, T Macaluso, M Padian, NS AF Minnis, Alexandra M. Steiner, Markus J. Gallo, Maria F. Warner, Lee Hobbs, Marcia M. van der Straten, Ariane Chipato, Tsungai Macaluso, Maurizio Padian, Nancy S. TI Biomarker Validation of Reports of Recent Sexual Activity: Results of a Randomized Controlled Study in Zimbabwe SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE biological markers; condoms; data collection; epidemiologic measurements; HIV; prostate-specific antigen; sexual behavior ID PROSTATE-SPECIFIC ANTIGEN; REPRODUCTIVE HEALTH RESEARCH; SELF-REPORT MEASURES; AUDIO COMPUTER; CONDOM USE; INTERVIEWING METHODS; CONTROLLED-TRIAL; VAGINAL FLUID; BEHAVIOR; HIV AB Challenges in the accurate measurement of sexual behavior in human immunodeficiency virus (HIV) prevention research are well documented and have prompted discussion about whether valid assessments are possible. Audio computer-assisted self-interviewing (ACASI) may increase the validity of self-reported behavioral data. In 2006-2007, Zimbabwean women participated in a randomized, cross-sectional study that compared self-reports of recent vaginal sex and condom use collected through ACASI or face-to-face interviewing (FTFI) with a validated objective biomarker of recent semen exposure (prostate-specific antigen (PSA) levels). Of 910 study participants, 196 (21.5%) tested positive for PSA, an indication of semen exposure during the previous 2 days. Of these 196 participants, 23 (11.7%) reported no sex in the previous 2 days, with no difference in reported sexual activity between interview modes (12.5% ACASI vs. 10.9% FTFI; Fisher's exact test: P = 0.72). In addition, 71 PSA-positive participants (36.2%) reported condom-protected vaginal sex only; their reports also indicated no difference between interview modes (33.7% ACASI vs. 39.1% FTFI; P = 0.26). Only 52% of PSA-positive participants reported unprotected sex during the previous 2 days. Self-report was a poor predictor of recent sexual activity and condom use in this study, regardless of interview mode, providing evidence that such data should be interpreted cautiously. C1 [Minnis, Alexandra M.; van der Straten, Ariane; Padian, Nancy S.] RTI Int, Womens Global Hlth Imperat, San Francisco, CA 94104 USA. [Minnis, Alexandra M.; Padian, Nancy S.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Steiner, Markus J.] Family Hlth Int, Res Triangle Pk, NC 27709 USA. [Gallo, Maria F.; Warner, Lee; Macaluso, Maurizio] Ctr Dis Control & Prevent, Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA USA. [Hobbs, Marcia M.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [van der Straten, Ariane] Univ Calif San Francisco, Dept Med, Ctr AIDS Prevent Studies, San Francisco, CA USA. [Chipato, Tsungai] Univ Zimbabwe, UZ UCSF Res Programme Womens Hlth, Harare, Zimbabwe. RP Minnis, AM (reprint author), RTI Int, Womens Global Hlth Imperat, 114 Sansome St,Suite 500, San Francisco, CA 94104 USA. EM aminnis@rti.org RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 FU US Agency for International Development [GPO-A-OO-05-00022-00]; Contraceptive and Reproductive Health Technologies and Research Utilization Program; Bill and Melinda Gates Foundation [21082] FX Conflict of interest: none declared. NR 37 TC 97 Z9 97 U1 1 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 1 PY 2009 VL 170 IS 7 BP 918 EP 924 DI 10.1093/aje/kwp219 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 499JY UT WOS:000270217600015 PM 19741042 ER PT J AU Waters, MA Grajewski, B Pinkerton, LE Hein, MJ Zivkovich, Z AF Waters, Martha A. Grajewski, Barbara Pinkerton, Lynne E. Hein, Misty J. Zivkovich, Zachary TI Development of Historical Exposure Estimates of Cosmic Radiation and Circadian Rhythm Disruption for Cohort Studies of Pan Am Flight Attendants SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE cosmic radiation; flight attendants; exposure assessment; aircraft; flight crew; retrospective ID CANCER INCIDENCE; CABIN ATTENDANTS; DOSE ESTIMATION; AIRLINE PILOTS; PUBLISHED DATA; CREW; RISK AB Background The National Institute for Occupational Safety and Health is conducting cohort studies of flight crew employed by the former Pan American World Airways company (Pan Am) as part of an effort to examine flight crew work-place exposures and 14 health effects. Flight crew are exposed to elevated levels of cosmic radiation and to disruption of circadian rhythm when flying across multiple time zones. Methods exist to calculate cosmic radiation effective closes on individual flights; however, only work histories which provided an employee's domicile (home base) history rather than a record of every flight flown were available. Methods/Results We developed a method for estimating individual cumulative domicile-based cosmic radiation effective closes and two metrics for circadian rhythm disruption for each flight attendant: cumulative times zones crossed and cumulative travel time during the standard sleep interval. Conclusions The domicile-exposure matrix developed was used to calculate exposure estimates for a cohort mortality study of former Pan Am flight attendants. Am. J. Ind. Med. 52:751-761, 2009. Published 2009 Wiley-Liss, Inc. C1 [Waters, Martha A.; Grajewski, Barbara; Pinkerton, Lynne E.; Hein, Misty J.; Zivkovich, Zachary] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Grajewski, B (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy R-15, Cincinnati, OH 45226 USA. EM bag2@cdc.gov RI Waters, Martha/B-7441-2011 NR 28 TC 11 Z9 12 U1 1 U2 7 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD OCT PY 2009 VL 52 IS 10 BP 751 EP 761 DI 10.1002/ajim.20738 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 499BM UT WOS:000270191500003 PM 19722196 ER PT J AU Wang, ML Avashia, BH Petsonk, EL AF Wang, Mei Lin Avashia, Bipin H. Petsonk, Edward L. TI Interpreting Longitudinal Spirometry: Weight Gain and Other Factors Affecting the Recognition of Excessive FEV1 Decline SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE mass screening; excessive FEV1 decline; spirometry; mixed model; longitudinal data ID FORCED EXPIRATORY VOLUME; PULMONARY-FUNCTION DECLINE; LUNG-FUNCTION TESTS; SMOKING-CESSATION; ADULTS; VARIABILITY; INDIVIDUALS; POSITION AB Background Excessive FEV1 loss in an individual or a group can reflect hazardous exposures and development of lung disease. However, multiple factors may affect FEV1 measurements. Methods Using medical screening data collected in 1884 chemical plant workers between 1973 and 2003, the influence of multiple factors on repeated measurements of FEV1 was examined. Results The FEV1 level was associated with age, height, race, sex, cigarette smoking, changes in body weight, and spirometer model. After controlling for these factors, longitudinal FEV1 decline averaged 23.8 ml/year for white males; an additional loss of 8.3 ml was associated with one pack-year smoking and 5.4 ml with a one pound weight gain. Depending on the spirometer model, FEV1 differed by up to 95 ml. Conclusions The study results provide quantitative estimates of the effect of specific factors on FEV1, and should be useful to health professionals in the evaluation of accelerated lung function declines. Am. J. Ind. Med. 52:782-789, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Wang, Mei Lin; Petsonk, Edward L.] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent CDC, Morgantown, WV 26505 USA. [Avashia, Bipin H.] Inst Plant, Dept Med, Morgantown, WV USA. RP Petsonk, EL (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent CDC, Mail Stop H-G900-2,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM elp2@cdc.gov FU NIOSH FX Contract grant sponsor: NIOSH. NR 31 TC 5 Z9 5 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD OCT PY 2009 VL 52 IS 10 BP 782 EP 789 DI 10.1002/ajim.20727 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 499BM UT WOS:000270191500006 PM 19670262 ER PT J AU Jagger, J Berguer, R Gomaa, AE AF Jagger, Janine Berguer, Ramon Gomaa, Ahmed E. TI Study methods affect findings of safety trial of blunt suture needles SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 [Jagger, Janine] Univ Virginia Hlth Syst, Charlottesville, VA 22908 USA. [Berguer, Ramon] Univ Calif Davis, Dept Surg, Davis, CA 95616 USA. [Gomaa, Ahmed E.] NIOSH, Div Surveillance Hazard Evaluat & Hlth Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Jagger, J (reprint author), Univ Virginia Hlth Syst, POB 800764, Charlottesville, VA 22908 USA. EM jcj@virginia.edu NR 4 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 2009 VL 201 IS 4 BP E11 EP E12 DI 10.1016/j.ajog.2009.04.043 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 502LP UT WOS:000270461800043 PM 19539893 ER PT J AU Weaver, JB Mays, D Weaver, SS Kannenberg, W Hopkins, GL Eroglu, D Bernhardt, JM AF Weaver, James B., III Mays, Darren Weaver, Stephanie Sargent Kannenberg, Wendi Hopkins, Gary L. Eroglu, Dogan Bernhardt, Jay M. TI Health-Risk Correlates of Video-Game Playing Among Adults SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID MOOD-MANAGEMENT; BEHAVIOR-CHANGE; SELECTIVE EXPOSURE; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; TELEVISION; ADOLESCENTS; TIME; COMPUTER; ADDICTION AB Background: Although considerable research suggests that health-risk factors vary as a function of video-game playing among young people, direct evidence of such linkages among adults is lacking. Purpose: The goal of this Study was to distinguish adult video-game players from nonplayers on the basis of personal and environmental factors. It was hypothesized that adults who play video games, compared to nonplayers, would evidence poorer perceptions of their health, greater reliance on Internet-facilitated social support, more extensive media use, and higher BMI. It was further hypothesized that different patterns of linkages between video-game playing and health-risk factors would emerge by gender. Methods: A cross-sectional, Internet-based survey was conducted in 2006 with a sample of adults from the Seattle-Tacoma area (n=562), examining health risks; media use behaviors and perceptions, including those related to video-game playing; and demographics. Statistical analyses conducted in 2008 to compare video-game players and nonplayers included bivariate descriptive statistics, stepwise discriminant analysis, and ANOVA. Results: A total of 45.1% of respondents reported playing video games. Female video-game players reported greater depression (M=1.57) and poorer health status (M=3.90) than female nonplayers (depression, M=1.13; health status, M=3.57). Male video-game players reported higher BMI (M=5.31) and more Internet use time (M=2.55) than male nonplayers (BMI, M=5.19; Internet use, M=2.36). The only determinant common to female and male video-game players was greater reliance on the Internet for social support. Conclusions: A number of determinants distinguished video-game players from nonplayers, and these factors differed substantially between men and women. The data illustrate the need for further research among adults to clarify how to use digital opportunities more effectively to promote health and prevent disease. (Am J Prev Med 2009;37(4):299-305) (C) 2009 American journal of Preventive Medicine C1 [Weaver, James B., III; Mays, Darren; Weaver, Stephanie Sargent; Eroglu, Dogan; Bernhardt, Jay M.] CDC, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA. [Mays, Darren] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Kannenberg, Wendi; Hopkins, Gary L.] Andrews Univ, Inst Prevent Addict, Ctr Media Impact Res, Berrien Springs, MI 49104 USA. RP Weaver, JB (reprint author), CDC, Natl Ctr Hlth Mkt, 1600 Clifton Rd,MS-E21, Atlanta, GA 30333 USA. EM jim.weaver@cdc.gov OI Bernhardt, Jay/0000-0002-2045-4005 FU Center for Media Impact Research FX The authors are indebted to Richard E. Dixon, Marinella Marci, Duane C. McBride, andjohn V. StevensJr. for their significant contributions to this project. This research was supported in part by a grant from the Center for Media Impact Research in the Institute for Prevention of Addictions at Andrews University and by appointments of JBW, DM, and SSW to the Research Participation Program at the CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement NR 51 TC 26 Z9 26 U1 2 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD OCT PY 2009 VL 37 IS 4 BP 299 EP 305 DI 10.1016/j.amepre.2009.06.014 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 500WO UT WOS:000270336800006 PM 19765501 ER PT J AU Naimi, TS Nelson, DE Brewer, RD AF Naimi, Timothy S. Nelson, David E. Brewer, Robert D. TI Driving After Binge Drinking SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID MULTILEVEL ANALYSIS; UNITED-STATES; US ADULTS; ALCOHOL; SETTINGS; DRUNKENNESS; CONSUMPTION; GENDER; PLACES; RISK AB Background: Although binge drinking is strongly associated with alcohol-impaired driving, little is known about the prevalence of or risk factors for driving after binge drinking. Purpose: The purpose of this study was to assess the prevalence of, and risk factors for, driving during or shortly after a specific binge drinking episode. Methods: The data were analyzed in 2007 and 2008 from 14,085 adults from 13 states in 2003 and 14 states in 2004 who reported binge drinking and answered an additional series of questions about binge drinking behaviors as part of the Behavioral Risk Factor Surveillance System survey. Binge drinking was defined as the consumption of five or more drinks during a drinking occasion. Results: Overall, 11.9% of binge drinkers drove during or within 2 hours of their most recent binge drinking episode. Those drinking in licensed establishments (bars, clubs, and restaurants) accounted for 54.3% of these driving episodes. Significant independent risk factors for driving after binge drinking included male gender (AOR=1.75); being aged 35-54 or >= 55 years compared to 18-34 years (AOR=1.58 and 2.37, respectively); and drinking in bars or clubs compared to drinking in the respondent's home (AOR=7.81). Drivers who drank most of their alcohol in licensed establishments consumed an average of 8.1 drinks, and 25.7% of them consumed >= 10 drinks. Conclusions: Because binge drinking and subsequent driving were common in establishments licensed to sell alcohol, and because licensing is conditional on responsible beverage service practices (i.e., not selling to intoxicated people), efforts to prevent impaired driving should focus on enforcing responsible beverage service in licensed establishments. (Am J Prev Med 2009;37 (4):314-320) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Naimi, Timothy S.; Nelson, David E.; Brewer, Robert D.] CDC, Alcohol Team, Emerging Invest & Analyt Methods Branch, Div Adult & Community Hlth,Natl Ctr Chron Dis Pre, Atlanta, GA 30333 USA. RP Naimi, TS (reprint author), ZPHS Hosp, POB 467, Zuni, NM 87327 USA. EM tnaimi@post.harvard.edu NR 31 TC 25 Z9 25 U1 2 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD OCT PY 2009 VL 37 IS 4 BP 314 EP 320 DI 10.1016/j.amepre.2009.06.013 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 500WO UT WOS:000270336800008 PM 19765503 ER PT J AU Anderson, LM Quinn, TA Glanz, K Ramirez, G Kahwati, LC Johnson, DB Buchanan, LR Archer, WR Chattopadhyay, S Kalra, GP Katz, DL AF Anderson, Laurie M. Quinn, Toby A. Glanz, Karen Ramirez, Gilbert Kahwati, Leila C. Johnson, Donna B. Buchanan, Leigh Ramsey Archer, W. Roodly Chattopadhyay, Sajal Kalra, Geetika P. Katz, David L. CA Task Force Community Preventive TI The Effectiveness of Worksite Nutrition and Physical Activity Interventions for Controlling Employee Overweight and Obesity A Systematic Review SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HEALTH-PROMOTION PROGRAM; COMMUNITY-PREVENTIVE-SERVICES; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK-FACTORS; WEIGHT-LOSS COMPETITIONS; FITNESS PROGRAM; COST-EFFECTIVENESS; CHOLESTEROL LEVELS; SMOKING CESSATION; LIFE-STYLE AB This report presents the results of a systematic review of the effectiveness of worksite nutrition and physical activity programs to promote healthy weight among employees. These results form the basis for the recommendation by the Task Force on Community Preventive Services on the use of these interventions. Weight-related outcomes, including weight in pounds or kilograms, BMI, and percentage body fat were used to assess effectiveness of these programs. This review found that worksite nutrition and physical activity programs achieve modest improvements in employee weight status at the 6-12-month follow-up. A pooled effect estimate of -2.8 pounds (95% CI=-4.6, -1.0) was found based on nine RCTs, and a decrease in BMI of -0.5 (95% CI=-0.8, -0.2) was found based on six RCTs. The findings appear to be applicable to both male and female employees, across a range of worksite settings. Most of the studies combined informational and behavioral strategies to influence diet and physical activity; fewer studies modified the work environment (e.g., cafeteria, exercise facilities) to promote healthy choices. Information about other effects, barriers to implementation, cost and cost effectiveness of interventions, and research gaps are also presented in this article. The findings of this systematic review can help inform decisions of employers, planners, researchers, and other public health decision makers. (Am J Prev Med 2009;37(4):340-357) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Anderson, Laurie M.; Quinn, Toby A.; Chattopadhyay, Sajal; Kalra, Geetika P.] CDC, Community Guide Branch, Div Hlth Commun & Mkt, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA. [Buchanan, Leigh Ramsey; Archer, W. Roodly] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Glanz, Karen] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Ramirez, Gilbert] Charles R Drew Univ Med & Sci, Coll Sci & Hlth, Los Angeles, CA 90059 USA. [Kahwati, Leila C.] Natl Ctr Hlth Promot & Dis Prevent, Dept Vet Affairs, Durham, NC USA. [Johnson, Donna B.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Katz, David L.] Yale Prevent Res Ctr, New Haven, CT USA. RP Anderson, LM (reprint author), Community Prevent Serv, 1600 Clifton Rd,Mailstop E-69, Atlanta, GA 30333 USA. EM LAA1@cdc.gov OI Katz, David/0000-0001-6845-6192 NR 97 TC 213 Z9 216 U1 13 U2 116 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD OCT PY 2009 VL 37 IS 4 BP 340 EP 357 DI 10.1016/j.amepre.2009.07.003 PG 18 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 500WO UT WOS:000270336800012 PM 19765507 ER PT J AU Shults, RA Elder, RW Nichols, JL Sleet, DA Compton, R Chattopadhyay, SK AF Shults, Ruth A. Elder, Randy W. Nichols, James L. Sleet, David A. Compton, Richard Chattopadhyay, Sajal K. CA Task Force Community Preventive TI Effectiveness of Multicomponent Programs with Community Mobilization for Reducing Alcohol-Impaired Driving SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SUBSTANCE-ABUSE; RANDOMIZED-TRIAL; FIGHTING BACK; CRASHES; PREVENTION; DRINKING; INTERVENTIONS; COALITIONS; INJURIES; LESSONS AB A systematic review was conducted to determine the effectiveness and economic efficiency of multicomponent programs with community mobilization for reducing alcohol-impaired driving. The review was conducted for the Guide to Community Preventive Services (Community Guide). Six studies of programs qualified for the review. Programs addressed a wide range of alcohol-related concerns in addition to alcohol-impaired driving. The programs used various crash-related outcomes to measure their effectiveness. Two studies examined fatal crashes and reported declines of 9% and 42%; one study examined injury crashes and reported a decline of 10%; another study examined crashes among young drivers aged 16-20 years and reported a decline of 45%; and one study examined single-vehicle late-night and weekend crashes among young male drivers and reported no change. The sixth study examined injury crashes among underage drivers and reported small net reductions. Because the actual numbers of crashes were not reported, percentage change could not be calculated. According to Community Guide rules of evidence, the studies reviewed here provided strong evidence that carefully planned, well-executed multicomponent programs, when implemented in conjunction with community mobilization efforts, are effective in reducing alcohol-related crashes. Three studies reported economic evidence that suggests that such programs produce cost savings. The multicomponent programs generally included a combination of efforts to limit access to alcohol (particularly among youth), responsible beverage service training, sobriety checkpoints or other well-defined enforcement efforts, public education, and media advocacy designed to gain the support of both policymakers and the general public for reducing alcohol-impaired driving. (Am J Prev Med 2009;37(4):360-371) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Shults, Ruth A.; Sleet, David A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Elder, Randy W.; Chattopadhyay, Sajal K.] CDC, Div Hlth Commun & Mkt, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA. [Nichols, James L.; Compton, Richard] Natl Highway Traff Safety Adm US, Off Res & Traff Records, Washington, DC 20590 USA. RP Shults, RA (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway,Mailstop F-62, Atlanta, GA 30341 USA. EM rshults@cdc.gov NR 46 TC 34 Z9 34 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD OCT PY 2009 VL 37 IS 4 BP 360 EP 371 DI 10.1016/j.amepre.2009.07.005 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 500WO UT WOS:000270336800014 PM 19765509 ER PT J AU Blumberg, SJ Luke, JV AF Blumberg, Stephen J. Luke, Julian V. TI Reevaluating the Need for Concern Regarding Noncoverage Bias in Landline Surveys SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID TELEPHONE COVERAGE; YOUNG-ADULTS; ADJUSTMENTS; STATE AB Objectives. We used recent data to reexamine whether the exclusion of adults from households with no telephone or only wireless phones may bias estimates derived from health-related telephone surveys. Methods. We calculated the difference between estimates for the full population of adults and estimates for adults with landline phones; data were from the 2007 National Health Interview Survey. Results. When data from landline telephone surveys were weighted to match demographic characteristics of the full population, bias was generally less than 2 percentage points (range=0.1-2.4). However, among young adults and low-income adults, we found greater bias (range=1.7-5.9) for estimates of health insurance, smoking, binge drinking, influenza vaccination, and having a usual place for care. Conclusions. From 2004 to 2007, the potential for noncoverage bias increased. Bias can be reduced through weighting adjustments. Therefore, telephone surveys limited to landline households may still be appropriate for health surveys of all adults and for surveys of subpopulations regarding health status. However, for some behavioral risk factors and health care service use indicators, caution is warranted when using landline surveys to draw inferences about young or low-income adults. (Am J Public Health. 2009;99:1806-1810. doi:10.2105/AJPH.2008.152835) C1 [Blumberg, Stephen J.; Luke, Julian V.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Blumberg, SJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 2112, Hyattsville, MD 20782 USA. EM sblumberg@cdc.gov NR 22 TC 83 Z9 84 U1 1 U2 7 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 IS 10 BP 1806 EP 1810 DI 10.2105/AJPH.2008.152835 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 507IS UT WOS:000270846500016 PM 19696381 ER PT J AU Baron, S McPhaul, K Phillips, S Gershon, R Lipscomb, J AF Baron, Sherry McPhaul, Kathleen Phillips, Sally Gershon, Robyn Lipscomb, Jane TI Protecting Home Health Care Workers: A Challenge to Pandemic Influenza Preparedness Planning SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID COMMUNITY-HEALTH; UNITED-STATES; SAFETY; PEER; RECOMMENDATIONS; EDUCATION; TRAINERS; SERVICES; AIDES AB The home health care sector is a critical element in a pandemic influenza emergency response. Roughly 85% of the 1.5 million workers delivering in-home care to 7.6 million clients are low-wage paraprofessionals, mostly women, and disproportionately members of racial and ethnic minorities. Home health care workers' ability and willingness to respond during a pandemic depends on appropriate communication, training, and adequate protections, including influenza vaccination and respiratory protection. Preparedness planning should also include support for child care and transportation and help home health care workers protect their income and access to health care. We summarize findings from a national stakeholder meeting, which highlighted the need to integrate home health care employers, workers, community advocates, and labor unions into the planning process. (Am J Public Health. 2009;99-S301-S307. doi:10.2105/AJPH.2008.157339) C1 [Baron, Sherry] Ctr Dis Control & Prevent, NIOSH, Cincinnati, OH USA. [McPhaul, Kathleen; Lipscomb, Jane] Univ Maryland, Sch Nursing, Work & Hlth Res Ctr, Baltimore, MD 21201 USA. [Phillips, Sally] Agcy Healthcare Res & Qual, Rockville, MD USA. [Gershon, Robyn] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. RP Baron, S (reprint author), 4676 Columbia Pkwy,MS R-17, Cincinnati, OH 45226 USA. EM SBaron@cdc.gov NR 44 TC 6 Z9 7 U1 2 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S301 EP S307 DI 10.2105/AJPH.2008.157339 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800015 PM 19461108 ER PT J AU Bouye, K Truman, BI Hutchins, S Richard, R Brown, C Guillory, JA Rashid, J AF Bouye, Karen Truman, Benedict I. Hutchins, Sonja Richard, Roland Brown, Clive Guillory, Joyce A. Rashid, Jamila TI Pandemic Influenza Preparedness and Response Among Public-Housing Residents, Single-Parent Families, and Low-Income Populations SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID NEW-YORK-CITY; UNITED-STATES; HEALTH; INTERVENTION; IMMUNIZATION; STRATEGIES; MEDICINE; PROJECT; IMPACT; WOMEN AB During the early stages of an influenza pandemic, a pandemic vaccine likely will not be available. Therefore, interventions to mitigate pandemic influenza transmission in communities will be an important component of the response to a pandemic. Public-housing residents, single-parent families, and low-income populations may have difficulty complying with community-wide interventions. To enable compliance with Community interventions, stakeholders recommended the following: (1) community mobilization and partnerships, (2) culturally specific emergency communications planning, (3) culturally specific education and training programs, (4) evidence-based measurement and evaluation efforts, (5) strategic planning policies, (6) inclusion of community members as partners, and (7) policy and program changes to minimize morbidity and mortality. (Am J Public Health 2009;99-S287-S293. doi:10.2105/AJPH.2009.165134) C1 [Bouye, Karen] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth, Off Director, Atlanta, GA 30333 USA. [Brown, Clive] CDC, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [Guillory, Joyce A.] Faith Journey Partnership Parish Minist, Interdenominat Theol Ctr, Atlanta, GA USA. [Rashid, Jamila] CDC, Coordinating Off Terrorism Preparedness & Emergen, Atlanta, GA 30333 USA. RP Bouye, K (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth, Off Director, 1600 Clifton Rd NE, Mail Stop E-67, Atlanta, GA 30333 USA. OI Hutchins, Sonja/0000-0002-7557-1006 NR 51 TC 8 Z9 8 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S287 EP S293 DI 10.2105/AJPH.2009.165134 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800013 PM 19797740 ER PT J AU Campbell, VA Gilyard, JA Sinclair, L Sternberg, T Kailes, JI AF Campbell, Vincent A. Gilyard, Jamylle A. Sinclair, Lisa Sternberg, Tom Kailes, June I. TI Preparing for and Responding to Pandemic Influenza: Implications for People With Disabilities SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID HEALTH-CARE NEEDS; PREPAREDNESS; CHILDREN AB State, local, tribal, and territorial emergency managers and public health officials must address the specific needs of people with disabilities in their pandemic influenza plans. Evidence from Hurricane Katrina indicated that this population was disproportionately affected by the storm and aftermath. People with disabilities, particularly those who require personal assistance and those who reside in congregate care facilities, may be at increased risk during an influenza pandemic because of disrupted care or the introduction of the virus by their caregivers. Emergency and public health planners must ensure that personal assistance agencies and congregate care operators make provisions for backup staffing and that those who provide critical care are given adequate antiviral drugs and vaccines as they become available (Am J Public Health. 2009; 99:S294-S300. doi:10.2105.AJPH.2009.162677) C1 [Campbell, Vincent A.; Gilyard, Jamylle A.; Sinclair, Lisa; Sternberg, Tom] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Disabil & Hlth Branch, Atlanta, GA 30329 USA. [Sternberg, Tom] Med Staffing Network, Atlanta, GA USA. [Kailes, June I.] Western Univ Hlth Sci, Ctr Disabil Issues & Hlth Profess, Pomona, CA USA. RP Campbell, VA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Disabil & Hlth Branch, 1600 Clifton Rd,MS-E-88, Atlanta, GA 30329 USA. EM vbc6@cdcc.gov NR 50 TC 7 Z9 7 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S294 EP S300 DI 10.2105/AJPH.2009.162677 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800014 PM 19797741 ER PT J AU Groom, AV Jim, C LaRoque, M Mason, C McLaughlin, J Neel, L Powell, T Weiser, T Bryan, RT AF Groom, Amy V. Jim, Cheyenne LaRoque, Mic Mason, Cheryl McLaughlin, Joe Neel, Lisa Powell, Terry Weiser, Thomas Bryan, Ralph T. TI Pandemic Influenza Preparedness and Vulnerable Populations in Tribal Communities SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID INVASIVE PNEUMOCOCCAL DISEASE; AMERICAN INDIANS/ALASKA NATIVES; RESISTANT STAPHYLOCOCCUS-AUREUS; ALASKA NATIVES; RESPIRATORY-TRACT; SUPPLEMENTARY SURVEY; INDIAN COUNTRY; EPIDEMIOLOGY; INFECTIONS; PREVENTION AB American Indian and Alaska Native (AIAN) governments are sovereign entities with inherent authority to establish and administer public health programs within their communities and will be critical partners in national efforts to prepare for pandemic influenza. Within AIAN communities, some subpopulations will be particularly vulnerable during an influenza pandemic because of their underlying health conditions whereas others will be a; increased risk because of limited access to prevention or treatment interventions. We outline potential issues to consider in identifying and providing appropriate services for selected vulnerable populations within tribal communities We also highlight pandemic Influenza preparedness resources available to tribal leaders and their partners in state and local health departments, academia, community-based organizations, and the private sector. (Am J Public Health. 2009; 99 S271-S278. dot. 10 2105/AJPH.2008.157453) C1 [Groom, Amy V.; Jim, Cheyenne] IHS, Div Epidemiol & Dis Prevent, Albuquerque, NM 87110 USA. [Groom, Amy V.; Jim, Cheyenne] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [LaRoque, Mic] IHS, Gallup Indian Med Ctr, Gallup, NM USA. [McLaughlin, Joe] Alaska Sect Epidemiol, Anchorage, AK USA. [Powell, Terry] Alaska Area Inst Review Board, Anchorage, AK USA. [Weiser, Thomas] IHS, Portland Area Off, Portland, OR USA. [Bryan, Ralph T.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, Atlanta, GA USA. RP Groom, AV (reprint author), IHS, Div Epidemiol & Dis Prevent, 5300 Homestead Rd NE, Albuquerque, NM 87110 USA. NR 77 TC 22 Z9 24 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S271 EP S278 DI 10.2105/AJPH.2008.157453 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800011 PM 19461107 ER PT J AU Heffelfinger, JD Patel, P Brooks, JT Calvet, H Daley, CL Dean, HD Edlin, BR Gensheimer, KF Jereb, J Kent, CK Lennox, JL Louie, JK Lynfield, R Peters, PJ Pinckney, L Spradling, P Voetsch, AC Fiore, A AF Heffelfinger, James D. Patel, Pragna Brooks, John T. Calvet, Helene Daley, Charles L. Dean, Hazel D. Edlin, Brian R. Gensheimer, Kathleen F. Jereb, John Kent, Charlotte K. Lennox, Jeffrey L. Louie, Janice K. Lynfield, Ruth Peters, Philip J. Pinckney, Lauretta Spradling, Philip Voetsch, Andrew C. Fiore, Anthony TI Pandemic Influenza: Implications for Programs Controlling for HIV Infection, Tuberculosis, and Chronic Viral Hepatitis SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID HUMAN-IMMUNODEFICIENCY-VIRUS; LIVER-TRANSPLANT RECIPIENTS; IMMUNIZATION PRACTICES ACIP; UNITED-STATES; HIV-1-INFECTED PATIENTS; PULMONARY TUBERCULOSIS; SEASONAL INFLUENZA; ADVISORY-COMMITTEE; EXCESS MORTALITY; CONTROLLED-TRIAL AB Among vulnerable populations during an influenza pandemic are persons with or at risk for HIV infection, tuberculosis, or chronic viral hepatitis. HIV-infected persons have higher rates of hospitalization, prolonged illness, and increased mortality from influenza compared with the general population Persons with tuberculosis and chronic viral hepatitis may also be at increased risk of morbidity and mortality from influenza because of altered immunity and chronic illness. These populations also face social and structural barriers that will be exacerbated by a pandemic Existing infrastructure should be expanded and pandemic planning should include preparations to reduce the risks for these populations. (Am J Public Health. 2009,99.S333-S339 doi.10.2105/AJPH.2008.158170) C1 [Heffelfinger, James D.; Patel, Pragna; Brooks, John T.; Dean, Hazel D.; Jereb, John; Kent, Charlotte K.; Peters, Philip J.; Pinckney, Lauretta; Spradling, Philip; Voetsch, Andrew C.; Fiore, Anthony] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Calvet, Helene] Long Beach Dept Hlth & Human Serv, Long Beach, CA USA. [Daley, Charles L.] Natl Jewish Med & Res Ctr, Denver, CO USA. [Edlin, Brian R.] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA. [Gensheimer, Kathleen F.] Maine Dept Hlth & Human Serv, Augusta, ME USA. [Lennox, Jeffrey L.] Emory Univ, Atlanta, GA 30322 USA. [Louie, Janice K.] Calif Dept Publ Hlth, Berkeley, CA USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. RP Heffelfinger, JD (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mail Stop E-46, Atlanta, GA 30333 USA. EM tzh7@cdc.gov RI Lennox, Jeffrey/D-1654-2014; OI Lennox, Jeffrey/0000-0002-2064-5565; Edlin, Brian/0000-0001-8172-8797 NR 85 TC 5 Z9 5 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S333 EP S339 DI 10.2105/AJPH.2008.158170 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800019 PM 19797745 ER PT J AU Hutchins, SS Fiscella, K Levine, RS Ompad, DC McDonald, M AF Hutchins, Sonja S. Fiscella, Kevin Levine, Robert S. Ompad, Danielle C. McDonald, Marian CA Ctr Dis Control Prevention's TI Protection of Racial/Ethnic Minority Populations During an Influenza Pandemic SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID STAPHYLOCOCCUS-AUREUS INFECTIONS; COMMUNITY-ACQUIRED PNEUMONIA; RESPIRATORY SYNCYTIAL VIRUS; UNITED-STATES; PNEUMOCOCCAL BACTEREMIA; VACCINATION RATES; NEW-YORK; MORTALITY; COUNTY; SURVEILLANCE AB Racial/ethnic minority populations experience worse health outcomes than do other groups during and after disasters. Evidence for a differential impact from pandemic influenza includes both higher rates of underlying health conditions in minority populations, increasing their risk of influenza-related complications, and larger socioeconomic (e.g., access to health care), cultural, educational, and linguistic barriers to adoption of pandemic interventions. Implementation of pandemic interventions could be optimized by (1) culturally competent preparedness and response that address specific needs of racial/ethnic minority populations, (2) improvements in public health and community health safety net systems, (3) social policies that minimize economic burdens and improve compliance with isolation and quarantine, and (4) relevant, practical, and culturally and linguistically tailored communications (Am J Public Health. 2009;99.S261-S270 doi: 10.2105/AJPH.2009161505) C1 [Hutchins, Sonja S.] CDC, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Atlanta, GA 30333 USA. [McDonald, Marian] CDC, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [Fiscella, Kevin] Univ Rochester, Sch Med & Dent, Dept Family Med, Rochester, NY 14627 USA. [Fiscella, Kevin] Univ Rochester, Sch Med & Dent, Dept Community & Prevent Med, Rochester, NY 14627 USA. [Levine, Robert S.] Meharry Med Coll, Dept Family & Community Med, Nashville, TN 37208 USA. [Ompad, Danielle C.] New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA. RP Hutchins, SS (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, 1600 Clifton Rd,Mailstop E-67, Atlanta, GA 30333 USA. RI Ompad, Danielle/F-3163-2013; OI Ompad, Danielle/0000-0003-0240-0393; Hutchins, Sonja/0000-0002-7557-1006 NR 62 TC 32 Z9 33 U1 1 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S261 EP S270 DI 10.2105/AJPH.2009.161505 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800010 PM 19797739 ER PT J AU Hutchins, SS Truman, BI Merlin, TL Redd, SC AF Hutchins, Sonja S. Truman, Benedict I. Merlin, Toby L. Redd, Stephen C. TI Protecting Vulnerable Populations From Pandemic Influenza in the United States: A Strategic Imperative SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID MINORITY POPULATIONS; HURRICANE-KATRINA AB Protecting vulnerable populations from pandemic influenza is a strategic imperative. The US national strategy for pandemic influenza preparedness and response assigns roles to governments, businesses, civic and community-based organizations, individuals, and families. Because influenza is highly contagious, inadequate preparedness or untimely response invulnerable populations increases the risk of infection for the general population. Recent public health emergencies have reinforced the importance of preparedness and the challenges of effective response among vulnerable populations. We explore definitions and determinants of vulnerable, at-risk, and special populations and highlight approaches for ensuring that pandemic influenza preparedness includes these populations and enables them to respond appropriately. We also provide an overview of population-specific and cross-cutting articles in this theme issue on influenza preparedness for vulnerable populations. (Am J Public Health. 2009; 99:S243-S248. doi: 10.2105/AJPH.2009.164814) C1 [Hutchins, Sonja S.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, Atlanta, GA 30333 USA. [Merlin, Toby L.; Redd, Stephen C.] CDC, Influenza Coordinat Unit, Coordinat Infect Dis, Atlanta, GA 30333 USA. RP Hutchins, SS (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, 1600 Clifton Rd,Moalstop F-67, Atlanta, GA 30333 USA. OI Hutchins, Sonja/0000-0002-7557-1006 NR 48 TC 13 Z9 13 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S243 EP S248 DI 10.2105/AJPH.2009.164814 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800007 PM 19797737 ER PT J AU Leon, K McDonald, MC Moore, B Rust, G AF Leon, Kyla McDonald, Marian C. Moore, Barbara Rust, George TI Disparities in Influenza Treatment Among Disabled Medicaid Patients in Georgia SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID PANDEMIC INFLUENZA; HEALTH DISPARITIES; VACCINATION; PREVENTION AB Objectives. We explored possible disparities in seasonal influenza treatment in Georgia's disabled Medicaid population We sought to determine whether racial/ethnic, geographic, or gender disparities existed in antiviral drugs usage in the treatment of influenza. Methods. Medicaid claims were analyzed from 69556 clients with disabilities enrolled in a Georgia Medicaid disease management program. Results. There were 519 patients who met inclusion criteria (i.e., adults aged 18-64 years with an influenza diagnosis on a 2006 or 2007 Medicaid claim). Roughly one third (36.2%) of patients were classified as African American, 44.5% as White, and 19.3% as "other" Most patients had 2 or more comorbid chronic diseases. Antivirals were used in only 14.5% of patients diagnosed with influenza. Treatment rates were nearly 3 times higher for White patients (19.5%) than for African American patients (6.9%). Conclusions. Our analysis suggests limited use of antiviral treatment of influenza overall, as well as significant racial disparities in treatment, Additional studies are needed to further explore this finding and its implications for care of racial/ethnic minority populations during seasonal influenza and for effective pandemic influenza planning for racial/ethnic minority populations. (Am J Public Health. 2009;99:S378-S382 doi.10.2105/AJPH.2008.157602) C1 [Leon, Kyla; Moore, Barbara; Rust, George] Morehouse Sch Med, Natl Ctr Primary Care, Atlanta, GA 30310 USA. [McDonald, Marian C.] Ctr Dis Control & Prevent, OMWH, DEISS, NCPDCID, Atlanta, GA 30333 USA. RP McDonald, MC (reprint author), Ctr Dis Control & Prevent, OMWH, DEISS, NCPDCID, 1600 Clifton Rd NE,Mailstop D-62, Atlanta, GA 30333 USA. FU Association of Minority Health Professions Schools and Demta Walston of Moi chouse School of Medicine FX The authors acknowledge the James A Ferguson Emerging Infectious Diseases Fellowship Programs to Providing Kyla Leon's fellowship We thank Allison Hornbuckle of the Association of Minority Health Professions Schools and Demta Walston of Moi chouse School of Medicine for administrative support. NR 42 TC 6 Z9 6 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S378 EP S382 DI 10.2105/AJPH.2008.157602 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800027 PM 19461106 ER PT J AU Maruschak, LM Sabol, WJ Potter, RH Reid, LC Cramer, EW AF Maruschak, Laura M. Sabol, William J. Potter, R. H. Reid, Laurie C. Cramer, Emily W. TI Pandemic Influenza and Jail Facilities and Populations SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material AB Persons processed into and through jail facilities in the United States may be particularly vulnerable during an influenza pandemic Among other concerns, public health and corrections officials need to consider flow issues,the high turnover and transitions between jails and the community, and the decentralized organization of jails. In this article, we examine some of the unique challenges jail facilities may face during an influenza pandemic and discuss issues that should be addressed to reduce the spread of illness and lessen the impact of an influenza pandemic on the jail population and their surrounding communities. (A 177 J Public Health 2009,99:S339-S344 doi:10.2105/AJPH.2009.175174) C1 [Reid, Laurie C.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30024 USA. [Maruschak, Laura M.; Sabol, William J.] Bur Justice Stat, US Dept Justice, Washington, DC 20530 USA. [Potter, R. H.] Univ Cent Florida, Dept Criminal Justice & Legal Studies, Orlando, FL 32816 USA. RP Reid, LC (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,MS D-21, Atlanta, GA 30024 USA. NR 16 TC 3 Z9 4 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S339 EP S344 DI 10.2105/AJPH.2009.175174 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800020 PM 19797746 ER PT J AU Nelson, JC Bittner, RCL Bounds, L Zhao, SS Baggs, J Donahue, JG Hambidge, SJ Jacobsen, SJ Klein, NP Naleway, AL Zangwill, KM Jackson, LA AF Nelson, Jennifer C. Bittner, Rachel C. L. Bounds, Lora Zhao, Shanshan Baggs, James Donahue, James G. Hambidge, Simon J. Jacobsen, Steven J. Klein, Nicola P. Naleway, Allison L. Zangwill, Kenneth M. Jackson, Lisa A. TI Compliance With Multiple-Dose Vaccine Schedules Among Older Children, Adolescents, and Adults: Results From a Vaccine Safety Datalink Study SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HEPATITIS-A VACCINE; B-VACCINATION; VARICELLA VACCINE; RECOMBINANT-DNA; UNITED-STATES; IMMUNOGENICITY; ORGANIZATIONS; IMMUNIZATION; COMPLETION; PREDICTORS AB Objectives. We studied compliance with multiple-dose vaccine schedules, assessed factors associated with noncompliance, and examined timeliness of series completion among older children, adolescents, and adults Methods. We conducted a large, multisite, retrospective cohort study of older children, adolescents, and adults in the Vaccine Safety Datalink population from 1996 through 2004. We quantified the rates of completion of all required doses for varicella, hepatitis A, and hepatitis B vaccines according to their recommended schedules Results Among those who received a first dose of varicella (n=16075), hepatitis A (n=594917), and hepatitis B (n=590445) vaccine, relatively few completed the series (55%-65% for hepatitis B vaccine and 40%-50% for hepatitis A and varicella vaccines in most age groups) Compliance was lowest among adolescents (35.9%) and Medicaid recipients (29.7%) who received varicella vaccine and among younger adult age groups who received hepatitis A vaccine (25%-35% across those age groups) Even among series completers, there was a relatively long interval of undervaccination between the first and last doses Conclusions. Compliance with multiple-dose vaccine series among older children, adolescents, and adults is suboptimal. Further evaluations of strategies to improve compliance in these populations are needed. (Am J Public Health. 2009;99-S389-S397. doi:10.2105/AJPH.2008.151332) C1 [Nelson, Jennifer C.; Bittner, Rachel C. L.; Bounds, Lora; Zhao, Shanshan; Jackson, Lisa A.] Grp Hlth Res Inst, Seattle, WA USA. [Nelson, Jennifer C.; Bittner, Rachel C. L.; Zhao, Shanshan] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Baggs, James] Ctr Dis Control & Prevent, Atlanta, GA USA. [Donahue, James G.] Marshfield Clin Res Fdn, Epidemiol Res Ctr, Marshfield, WI USA. [Hambidge, Simon J.] Denver Hlth Community Hlth Serv, Kaiser Permanente Inst Hlth Res, Denver, CO USA. [Hambidge, Simon J.] Univ Colorado, Denver, CO 80202 USA. [Jacobsen, Steven J.] So Calif Permanente Med Grp, Pasadena, CA USA. [Klein, Nicola P.] No Calif Kaiser Permanente, Vaccine Study Ctr, Oakland, CA USA. [Klein, Nicola P.] No Calif Kaiser Permanente, Div Res, Oakland, CA USA. [Naleway, Allison L.] Kaiser Permanente NW, Ctr Hlth Res, Portland, OR USA. [Zangwill, Kenneth M.] Univ Calif Los Angeles, Ctr Vaccine Res, Los Angeles, CA USA. [Zangwill, Kenneth M.] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Los Angeles, CA USA. [Jackson, Lisa A.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Nelson, JC (reprint author), 1730 Minor Ave Suite 1600, Seattle, WA 98101 USA. OI Baggs, James/0000-0003-0757-4683; Naleway, Allison/0000-0001-5747-4643; Jacobsen, Steven/0000-0002-8174-8533 FU Centers for Disease Control and Prevention [200-2002-00732]; Merck and GlaxoSmithKline FX N P Klein received grant support from Merck and GlaxoSmithKline. S J Jacobsen received grant funding from and served as an unpaid consultant to Merck Research Labs L. Jackson received research funding from and has served as a consultant to vaccine manufacturers. including Sanofi Pasteur, Novartis, Wyeth, and GlaxoSmithKline NR 38 TC 22 Z9 22 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S389 EP S397 DI 10.2105/AJPH.2008.151332 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800029 PM 19797753 ER PT J AU Rasmussen, SA Jamieson, DJ MacFarlane, K Cragan, JD Williams, J Henderson, Z AF Rasmussen, Sonja A. Jamieson, Denise J. MacFarlane, Kitty Cragan, Janet D. Williams, Jennifer Henderson, Zsakeba CA Pandemic Influenza Pregnancy Worki TI Pandemic Influenza and Pregnant Women: Summary of a Meeting of Experts SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID MATERNAL FEVER; CONGENITAL-ABNORMALITIES; EMERGING INFECTIONS; RESPIRATORY ILLNESS; H5N1 INFECTION; RISK-FACTORS; AMANTADINE; INFANTS; SAFETY; HOSPITALIZATIONS AB Pandemic, influenza Special Considerations for Pregnant Women was a meeting convened by he Centers for Disease Control and Prevention in 2008 to obtain input from experts and key partners regarding clinical management of pregnant, women and related public health actions to be taken during a pandemic Meeting goals were to discuss issues specific to pregnant women, identify gaps in knowledge, and develop a public health approach for pregnant women in the event of a pandemic The meeting focused on 4 main topics. prophylaxis and treatment with influenza antiviral and other medications, vaccine use, nonpharmaceutical interventions am: health care planning, and Communications. Participants reviewed the available evidence to guide action in each of these areas and identified areas of critical needs for future research. (Am J Public Health. 2009;S,: S248-S254. doi:10.2105/AJPH.2008.152900) C1 [Rasmussen, Sonja A.; Cragan, Janet D.; Williams, Jennifer] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Jamieson, Denise J.; MacFarlane, Kitty; Henderson, Zsakeba] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Rasmussen, SA (reprint author), CDC, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. NR 59 TC 46 Z9 53 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S248 EP S254 DI 10.2105/AJPH.2008.152900 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800008 PM 19461110 ER PT J AU Rust, G Melbourne, M Truman, BI Daniels, E Fry-Johnson, Y Curtin, T AF Rust, George Melbourne, Mollie Truman, Benedict I. Daniels, Elvan Fry-Johnson, Yvonne Curtin, Thomas TI Role of the Primary Care Safety Net in Pandemic Influenza SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID PUBLIC-HEALTH SYSTEM; UNITED-STATES; ETHNIC DISPARITIES; SURGE CAPACITY; COMMUNITY; IMPACT; VACCINATION; MORTALITY; OUTBREAKS; ADULTS AB An influenza pandemic would have a disproportionately adverse impact on minority Populations, the poor, the uninsured, and those living in underserved communities Primary care practices serving the underserved would face special challenges in an influenza pandemic. Although nota formalized system, components of the primary care safety net include federally qualified health centers, public hospital clinics, volunteer or free clinics, and some local public health units. In the event of an influenza pandemic, the primary care safety net is needed to treat vulnerable populations and to provide health care surge capacity to prevent the overwhelming of hospital emergency departments. We examined the strength, capacity, and preparedness of key components of the primary care safety net in responding to pandemic influenza. (Am J Public Health. 2009;99: S316-S323. doi: 10.2105/AJPH.2009.161125) C1 [Rust, George; Daniels, Elvan; Fry-Johnson, Yvonne] Morehouse Sch Med, Natl Ctr Primary Care, Atlanta, GA 30310 USA. [Melbourne, Mollie; Curtin, Thomas] Natl Assoc Community Hlth Ctr, Bethesda, MD USA. [Truman, Benedict I.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA USA. RP Rust, G (reprint author), Morehouse Sch Med, Natl Ctr Primary Care, 720 Westview Dr, Atlanta, GA 30310 USA. FU AHRQ HHS [R24 HS019470]; NIMHD NIH HHS [U54 MD007588] NR 61 TC 3 Z9 3 U1 1 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S316 EP S323 DI 10.2105/AJPH.2009.161125 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800017 PM 19797743 ER PT J AU Santibanez, S Fiore, AE Merlin, TL Redd, S AF Santibanez, Scott Fiore, Anthony E. Merlin, Toby L. Redd, Stephen TI A Primer on Strategies for Prevention and Control of Seasonal and Pandemic Influenza SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID A H5N1 VIRUS; RANDOMIZED CONTROLLED-TRIAL; NEURAMINIDASE INHIBITOR ZANAMIVIR; RESPIRATORY SYNCYTIAL VIRUS; UNITED-STATES; NONPHARMACEUTICAL INTERVENTIONS; INHALED ZANAMIVIR; HUMAN INFECTION; SAFETY; CHILDREN AB The United States has made considerable progress in pandemic preparedness. Limited attention, however, has been given to the challenges faced by populations that will be at increased risk of the consequences of the pandemic, including challenges caused by societal, economic, and health-related factors. This supplement to the American Journal of Public Health focuses on the challenges faced by at-risk and vulnerable populations in preparing for and responding to an influenza pandemic. Here, we provide background information for subsequent articles throughout the supplement. We summarize (1) seasonal influenza epidemiology, transmission, clinical illness, diagnosis, vaccines, and antiviral medications; (2) H5N1 avian influenza; and (3) pandemic influenza vaccines, antiviral medications, and nonpharmaceutical interventions. (Am J Public Health. 2009;9 9: S216-S224. doi: 10.2105/AJPH.2009.164848) C1 [Santibanez, Scott; Merlin, Toby L.; Redd, Stephen] Ctr Dis Control & Prevent, Influenza Coordinat Unit, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Fiore, Anthony E.] Ctr Dis Control & Prevent, Epidemiol & Prevent Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Santibanez, S (reprint author), Ctr Dis Control & Prevent, Influenza Coordinat Unit, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS A-20, Atlanta, GA 30333 USA. NR 74 TC 11 Z9 12 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S216 EP S224 DI 10.2105/AJPH.2009.164848 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800003 PM 19797735 ER PT J AU Steege, AL Baron, S Davis, S Torres-Kilgore, J Sweeney, MH AF Steege, Andrea L. Baron, Sherry Davis, Shelley Torres-Kilgore, Judith Sweeney, Marie Haring TI Pandemic Influenza and Farmworkers: The Effects of Employment, Social, and Economic Factors SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID HIRED FARM-WORKERS; POULTRY WORKERS; HEALTH-STATUS; VIRUSES; MIGRANT; LEGAL; SWINE AB Employment, social, and economic factors have the potential to affect the magnitude of an influenza pandemic among farm-workers. Prevention efforts targeted toward livestock farm-workers, including increased access to seasonal influenza vaccine, risk reduction training, various forms of personal protection, and workplace sanitation, are needed. Crop and livestock farmworkers are at increased risk of exposure to influenza A viruses because of limited resources, substandard housing, immigration status, communication and cultural barriers, and discrimination. Recommendations were gathered from migrant clinicians, farm worker advocates, state and federal government agencies, industry stakeholders, and researchers to overcome these barriers, including surveillance of livestock farmworkers, inclusion of farmworker service organizations in plan ning efforts, and separation of immigration enforcement from emergency assistance. (Am J Public Health. 2009; 99 S308-S315. doi:10.2105/AJPH.2009.161091) C1 [Steege, Andrea L.; Baron, Sherry; Torres-Kilgore, Judith; Sweeney, Marie Haring] CDC, NIOSH, Cincinnati, OH 45226 USA. [Torres-Kilgore, Judith] Sch Publ Hlth, Ponce Sch Med, Ponce, PR USA. RP Steege, AL (reprint author), CDC, NIOSH, 4676 Columbia Pkwy MS R18, Cincinnati, OH 45226 USA. EM asteege@cdc.gov RI Steege, Andrea/H-8900-2016 OI Steege, Andrea/0000-0001-5665-2559 NR 56 TC 5 Z9 5 U1 2 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S308 EP S315 DI 10.2105/AJPH.2009.161091 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800016 PM 19797742 ER PT J AU Stevenson, E Barrios, L Cordell, R Delozier, D Gorman, S Koenig, LJ Odom, E Polder, J Randolph, J Shimabukuro, T Singleton, C AF Stevenson, Elizabeth Barrios, Lisa Cordell, Ralph Delozier, David Gorman, Susan Koenig, Linda J. Odom, Erica Polder, Jacquelyn Randolph, Jean Shimabukuro, Tom Singleton, Christa TI Pandemic Influenza Planning: Addressing the Needs of Children SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID DAY-CARE ATTENDANCE; RESPIRATORY ILLNESS; INFECTIONS; SUSCEPTIBILITY; HEALTH AB Children represent one quarter of the US population. Because of its enormous size and special needs, it is critically important to address this population group in pandemic influenza planning Here we describe the ways in which children are vulnerable in a pandemic, provide an overview of existing plans, summarize the resources available, and, given our experience with influenza A(H1N1), outline the evolving lessons we have learned with respect to planning for a severe influenza pandemic. We focus on a number of issues affecting children-vaccinations, medication availability, hospital capacity, and mental health concerns-and emphasize strategies that will protect children from exposure to the influenza virus, including infection control practices and activities in schools and child care programs. (Am J Public Health. 2009,99: S255-S260 doi:10 2105/AJPH.2009.159970) C1 [Stevenson, Elizabeth; Barrios, Lisa; Cordell, Ralph; Delozier, David; Gorman, Susan; Koenig, Linda J.; Odom, Erica; Polder, Jacquelyn; Randolph, Jean; Shimabukuro, Tom; Singleton, Christa] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Stevenson, E (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop D10, Atlanta, GA 30333 USA. EM bstevenson@cdc.gov NR 50 TC 13 Z9 13 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 BP S255 EP S260 DI 10.2105/AJPH.2009.159970 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800009 PM 19797738 ER PT J AU Sutton, MY Jones, RL Wolitski, RJ Cleveland, JC Dean, HD Fenton, KA AF Sutton, Madeline Y. Jones, Rhondette L. Wolitski, Richard J. Cleveland, Janet C. Dean, Hazel D. Fenton, Kevin A. TI A Review of the Centers for Disease Control and Prevention's Response to the HIV/AIDS Crisis Among Blacks in the United States, 1981-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HIV RISK BEHAVIORS; SEXUALLY-TRANSMITTED-DISEASES; HUMAN-IMMUNODEFICIENCY-VIRUS; RANDOMIZED CONTROLLED-TRIAL; DEMONSTRATION PROJECTS; AFRICAN-AMERICANS; SEX BEHAVIORS; INTERVENTIONS; INFECTION; MEN AB Among US racial/ethnic groups, Blacks are at the highest risk of acquiring HIV/AIDS. In response, the Centers for Disease Control and Prevention (CDC) has launched the Heightened National Response to Address the HIV/AIDS Crisis Among African Americans, which seeks to engage public and nonpublic partners in a synergistic effort to prevent HIV among Blacks. The CDC also recently launched Act Against AIDS, a campaign to refocus attention on the domestic HIV/AIDS crisis. Although the CDC's efforts to combat HIV/AIDS among Blacks have achieved some Success, more must be done to address this crisis. New initiatives include President Obama's goal of developing a National HIV/AIDS Strategy to reduce HIV incidence, decrease HIV-related health disparities, and increase access to care, especially among Blacks and other disproportionately affected populations. (Am J Public Health 2009;99:S351-S359 doi:10.2105/AJPH.2008.157958) C1 [Sutton, Madeline Y.; Jones, Rhondette L.; Wolitski, Richard J.; Cleveland, Janet C.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Dean, Hazel D.; Fenton, Kevin A.] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Sutton, MY (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-45, Atlanta, GA 30333 USA. NR 80 TC 33 Z9 34 U1 3 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S351 EP S359 DI 10.2105/AJPH.2008.157958 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800022 PM 19797748 ER PT J AU Thompson, WW Moore, MR Weintraub, E Cheng, PY Jin, XP Bridges, CB Bresee, JS Shay, DK AF Thompson, William W. Moore, Matthew R. Weintraub, Eric Cheng, Po-Yung Jin, Xiaoping Bridges, Carolyn B. Bresee, Joseph S. Shay, David K. TI Estimating Influenza-Associated Deaths in the United States SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID RESISTANT-STAPHYLOCOCCUS-AUREUS; RESPIRATORY SYNCYTIAL VIRUS; EPIDEMIC INFLUENZA; EXCESS MORTALITY; BACTERIAL PNEUMONIA; PANDEMIC INFLUENZA; IMPACT; ENGLAND; WALES; AGE AB Most estimates of US deaths associated with influenza circulation have been similar despite the use of different approaches. However, a recently published estimate suggested that previous estimates substantially overestimated deaths associated with influenza, and concluded that substantial numbers of deaths during a future pandemic could be prevented because of improvements in medical care. We reviewed the data sources and methods used to estimate influenza-associated deaths. We suggest that discrepancies between the recent estimate and previous estimates of the number of influenza-associated deaths are attributable primarily to the use of different outcomes and methods We also believe that secondary bacterial infections will likely result insubstantial morbidity and mortality during a future influenza pandemic, despite medical progress. (Am J Public Health 2009;99 S225-S230. doi:10.2105/AJPH.2008.151944) C1 [Thompson, William W.; Cheng, Po-Yung; Jin, Xiaoping; Bridges, Carolyn B.; Bresee, Joseph S.; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Moore, Matthew R.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Off Chief Sci Officer, Atlanta, GA 30333 USA. RP Thompson, WW (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, MS A32,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM wct2@cdc.gov OI Shay, David/0000-0001-9619-4820 NR 50 TC 56 Z9 59 U1 0 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S225 EP S230 DI 10.2105/AJPH.2008.151944 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800004 PM 19797736 ER PT J AU Truman, BI Tinker, T Vaughan, E Kapella, BK Brenden, M Woznica, CV Rios, E Lichtveld, M AF Truman, Benedict I. Tinker, Timothy Vaughan, Elaine Kapella, Bryan K. Brenden, Marta Woznica, Celine V. Rios, Elena Lichtveld, Maureen TI Pandemic Influenza Preparedness and Response Among Immigrants and Refugees SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID TO-REACH POPULATIONS; UNITED-STATES; ILLEGAL IMMIGRANTS; FOREIGN-BORN; HEALTH-CARE; UNDOCUMENTED IMMIGRANTS; OCCUPATIONAL-STATUS; STIGMA; SARS; WORKERS AB Some immigrants and refugees might be more vulnerable than other groups to pandemic influenza because of preexisting health and social disparities, migration history, and living conditions in the United States. Vulnerable populations and their service providers need information to overcome limited resources, in accessible health services, limited English proficiency and foreign language barriers. cross-cultural misunderstanding and inexperience applying recommended guidelines. To increase the utility of guidelines, we searched the literature, synthesized relevant findings, and examined their implications for vulnerable populations and stakeholders. Here we summarize advice from an expert pandemic public health scientists and service program managers who attended a meeting convened by the Centers for Disease Control and Prevention, May 1 and 2, 2008, in Atlanta, Georgia. (Am J Public Health. 2009; 99:S278-S286. doi:10.2105/AJPH.2008.154054) C1 [Truman, Benedict I.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, Atlanta, GA 30333 USA. [Kapella, Bryan K.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Tinker, Timothy] Booz Allen Hamilton, Mclean, VA USA. [Vaughan, Elaine] Univ Calif Irvine, Irvine, CA 92717 USA. [Brenden, Marta] Adm Children & Families, Div Refugee Assistance, Off Refugee Resettlement, Washington, DC USA. [Woznica, Celine V.] Heartland Alliance Human Needs & Human Rights, Chicago, IL USA. [Rios, Elena] Natl Hispan Med Assoc, Washington, DC USA. [Lichtveld, Maureen] Tulane Univ, New Orleans, LA 70118 USA. RP Truman, BI (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Off Chief Publ Hlth Practice, Off Director, 1600 Clifton Rd NE,Mailstop E-67, Atlanta, GA 30333 USA. EM btruman@cdc.gov NR 65 TC 15 Z9 15 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 2009 VL 99 SU 2 BP S278 EP S286 DI 10.2105/AJPH.2008.154054 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 512BY UT WOS:000271218800012 PM 19461109 ER PT J AU Lee, SW Lee, M Lee, DD Kim, C Kim, YJ Kim, JY Green, MD Klein, TA Kim, HC Nettey, H Ko, DH Kim, H Park, I AF Lee, Sei Won Lee, Minhee Lee, Dae Dong Kim, Changsoo Kim, Yeon-Joo Kim, Jung-Yeon Green, Michael D. Klein, Terry A. Kim, Heung Chul Nettey, Henry Ko, Dong Hoon Kim, Hyungsuk Park, Inho TI Biological Resistance of Hydroxychloroquine for Plasmodium vivax Malaria in the Republic of Korea SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IRIAN-JAYA; CHLOROQUINE; PROPHYLAXIS; PRIMAQUINE; FALCIPARUM; INDONESIA; DESETHYLCHLOROQUINE; CHEMOPROPHYLAXIS; HALOFANTRINE; MEFLOQUINE AB The Republic of Korea (ROK) Army instituted a vivax malaria chemoprophylaxis program (hydroxychloroquine [HCQ] 400 mg per week) in 1997 that was expanded to nearly 200,000 soldiers by 2007, raising concerns for the emergence of drug-resistant vivax malaria. Therefore, a study of whole blood HCQ concentrations for all malaria patients admitted to four ROK Army hospitals was conducted from June through September 2007. For all 142 vivax malaria patients enrolled, fevers returned to normal by Day 3 post-treatment and all thin blood films were negative for parasites by Day 7. Pre-treatment whole blood concentrations of HCQ for 14 patients were > 100 ng/mL. Eight of the patients were enrolled in the ROK Army chemoprophylaxis program that reported taking HCQ as directed, with the last pill taken >= 4 days before diagnosis. Although there was no evidence of clinical resistance, chemoprophylaxis data indicates the biological resistance or tolerance to HCQ in ROK. C1 [Park, Inho] Armed Forces Seoul Hosp, Profess Serv, Seoul 110200, South Korea. Armed Forces Capital Hosp, Dept Internal Med, Songnam, South Korea. [Lee, Sei Won] Armed Forces Capital Hosp, Dept Internal Med, Songnam 463040, Gyeonggi Do, South Korea. Armed Forces Ildong Hosp, Dept Internal Med, Pochon, South Korea. [Lee, Minhee] Armed Forces Ildong Hosp, Dept Internal Med, Pocheon Si 487840, Gyeonggi Do, South Korea. [Lee, Dae Dong] Armed Forces Yangju Hosp, Dept Lab Med, Yangju 482863, South Korea. [Kim, Changsoo] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 120752, South Korea. [Kim, Jung-Yeon] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, NIH, Seoul 122701, South Korea. Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA. USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Seoul, South Korea. [Klein, Terry A.] USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Med Brigade 65, Unit 15281, APO, AP 96205 USA. 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Seoul, South Korea. [Kim, Heung Chul] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, APO, AP 96205 USA. [Kim, Hyungsuk] Armed Forces Byuck Je Hosp, Dept Clin Pathol, Goyang 412779, South Korea. [Ko, Dong Hoon] Armed Forces Capital Hosp, Dept Internal Med, Songnam 463040, Gyeonggi Do, South Korea. RP Park, I (reprint author), Armed Forces Seoul Hosp, Profess Serv, Sokyuk Dong 165, Seoul 110200, South Korea. EM desire31@medimail.co.kr; park.afmc@gmail.com RI Valle, Ruben/A-7512-2013 FU AFHSC; GEIS; Silver Spring, MD; National Center for Military Intelligence, Fort Detrick, MD FX Funding for portions of this work was provided by the AFHSC, GEIS, Silver Spring, MD, and the National Center for Military Intelligence, Fort Detrick, MD. NR 35 TC 10 Z9 10 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 600 EP 604 DI 10.4269/ajtmh.2009.09-0102 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000013 PM 19815873 ER PT J AU Bukirwa, H Yau, V Kigozi, R Filler, S Ouick, L Lugemwa, M Dissanayake, G Kamya, M Wabwire-Mangen, F Dorsey, G AF Bukirwa, Hasifa Yau, Vincent Kigozi, Ruth Filler, Scott Ouick, Linda Lugemwa, Myers Dissanayake, Gunawardena Kamya, Moses Wabwire-Mangen, Fred Dorsey, Grant TI Short Report: Assessing the Impact of Indoor Residual Spraying on Malaria Morbidity Using a Sentinel Site Surveillance System in Western Uganda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VECTOR CONTROL; SOUTH-AFRICA AB A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility within the district 8 months before and 16 months after IRS. There was a consistent decrease in the proportion of patients diagnosed with clinical malaria after IRS for patients < 5 and > 5 years of age (52% versus 26%, P < 0.001 and 36%, versus 23%, P < 0.001, respectively). There was a large decrease in the proportion of positive blood smears in the first 4 months after IRS for patients < 5 (47% versus 14%, P < 0.001) and > 5 (26% versus 9%, P < 0.001) years of age, but this effect waned over the subsequent 12 months. IRS was effective in reducing malaria morbidity, but this was not sustained beyond 1 year for the proportion of blood smears read as positive. C1 [Bukirwa, Hasifa; Kigozi, Ruth] Infect Dis Res Collaborat, Uganda Malaria Surveillance Program, Kampala, Uganda. Uganda Malaria Surveillance Project, Kampala, Uganda. Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Filler, Scott; Ouick, Linda] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA 30341 USA. Uganda Minist Hlth, Natl Malaria Control Programme, Kampala, Uganda. [Dissanayake, Gunawardena] US Agcy Int Dev, US Miss Compound S Wing, Kampala, Uganda. [Kamya, Moses] Makerere Univ, Sch Med, Dept Med, Kampala, Uganda. [Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Yau, Vincent] Univ Calif Berkeley, Dept Epidemiol, Berkeley, CA 94720 USA. [Lugemwa, Myers] Minist Hlth, Natl Malaria Control Programme, Kampala, Uganda. RP Bukirwa, H (reprint author), Infect Dis Res Collaborat, Uganda Malaria Surveillance Program, POB 7475, Kampala, Uganda. EM hbukirwa@muucsf.org; vincentmyau@gmail.com; rkigozi@muucsf.org; SFiller@cdc.gov; maq2@CDC.GOV; myers_1956@hotmail.com; gdissanayake@usaid.gov; mkamya@infocom.co.ug; fwabwire@musph.ac.ug; gdorsey@medsfgh.ucsf.edu FU Centers for Disease Control and Prevention [U50/CCU925122] FX This study received financial support from the President's Malaria Initiative through a cooperative agreement with the Centers for Disease Control and Prevention (U50/CCU925122). NR 9 TC 23 Z9 24 U1 1 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 611 EP 614 DI 10.4269/ajtmh.2009.09-0126 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000015 PM 19815875 ER PT J AU Mayagaya, VS Michel, K Benedict, MQ Killeen, GF Wirtz, RA Ferguson, HM Dowell, FE AF Mayagaya, Valeliana S. Michel, Kristin Benedict, Mark Q. Killeen, Gerry F. Wirtz, Robert A. Ferguson, Heather M. Dowell, Floyd E. TI Non-destructive Determination of Age and Species of Anopheles gambiae s.l. Using Near-infrared Spectroscopy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE CHAIN-REACTION; AFRICAN MALARIA VECTORS; CUTICULAR HYDROCARBONS; WESTERN KENYA; REFLECTANCE SPECTROSCOPY; MOSQUITO POPULATIONS; INOCULATION RATE; CULICIDAE; TANZANIA; DIPTERA AB Determining, malaria vector species and age is crucial to measure malaria risk. Although different in ecology and susceptibility to control, the African malaria vectors Anopheles gambiae sensu stricto and An. arabiensis are morphologically similar and can be differentiated only by molecular techniques. Furthermore, few reliable methods exist to estimate the age of these vectors, which is a key predictor of malaria transmission intensity. We evaluated the use of near-infrared spectroscopy (LAIRS) to determine vector species and age. This non-destructive technique predicted the species of field-collected mosquitoes with approximately 80% accuracy and predicted the species of laboratory-reared insects with almost 100% accuracy. The relative age of young or old females was predicted with approximately 80% accuracy, and young and old insects were predicted with >= 90% accuracy. For applications where rapid assessment of the age structure and species composition of wild vector populations is needed, LAIRS offers a valuable alternative to traditional methods. C1 [Dowell, Floyd E.] USDA ARS, Engn & Wind Eros Res Unit, Grain Mkt & Prod Res Ctr, Manhattan, KS 66502 USA. Ifakara Hlth Inst, Biomed Unit, Ifakara Branch, Ifakara, Tanzania. Ifakara Hlth Inst, Biomed Unit, Dar Salaam Branch, Dar Es Salaam, Tanzania. [Michel, Kristin] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. [Benedict, Mark Q.] Int Atom Energy Agcy Labs, Div Human Hlth, A-2444 Seibersdorf, Austria. [Killeen, Gerry F.] Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England. [Ferguson, Heather M.] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8TA, Lanark, Scotland. [Wirtz, Robert A.] Ctr Dis Control & Prevent, Entomol Branch, Atlanta, GA 30341 USA. [Killeen, Gerry F.] Ifakara Hlth Inst, Coordinat Off, Dar Es Salaam, Tanzania. [Mayagaya, Valeliana S.] Ifakara Hlth Inst, Entomol Unit, Ifakara, Tanzania. RP Dowell, FE (reprint author), USDA ARS, Engn & Wind Eros Res Unit, Grain Mkt & Prod Res Ctr, 1515 Coll Ave, Manhattan, KS 66502 USA. EM vmayagaya@ihi.or.tz; kmichel@ksu.edu; m.benedict@iaea.org; gkilleen@ihi.or.tz; rwirtz@cdc.gov; hferg001@udef.gla.ac.uk; floyd.dowell@ars.usda.gov RI Michel, Kristin/F-3400-2011; OI Ferguson, Heather/0000-0002-9625-5176 FU International Atomic Energy Agency; Biotechnology and Biological Sciences Research Council; Wellcome Trust [076806] FX We thank Dr. Leon Hugo (Public Health Entomologist, Mosquito Control Laboratory. Queensland Institute of Medical Research. Herston, Queensland, Australia) and Dr. Benjamin Aldrich (Department of Anesthesia. University of Iowa, Iowa City, Iowa) for comments on early versions of this manuscript; Paul Howell (Malaria Research and Reference Reagent Resource Center, CDC) for providing mosquitoes; the International Atomic Energy Agency for providing fellowship funding to train Valeliana Mayagaya on the LAIRS technique; Kristina Wyatt. Heather Wilkins, and Kjersti Kjos for rearing mosquitoes at KSU; the Biotechnology and Biological Sciences Research Council for providing funding for field collections in Tanzania: the Wellcome Trust for supporting the contribution of Gerry F. Killeen through Research Career Development Fellowship number 076806: Elizabeth Maghirang for help in scanning mosquitoes and analyzing data; and the CDC for providing travel funds for field tests. NR 67 TC 33 Z9 34 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 622 EP 630 DI 10.4269/ajtmh.2009.09-0192 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000017 PM 19815877 ER PT J AU Anderson, AD Kruszon-Moran, D Loftis, AD McQuillan, G Nicholson, WL Priestley, RA Candee, AJ Patterson, NE Massung, RF AF Anderson, Alicia D. Kruszon-Moran, Deanna Loftis, Amanda D. McQuillan, Geraldine Nicholson, William L. Priestley, Rachel A. Candee, Amanda J. Patterson, Nicole E. Massung, Robert F. TI Seroprevalence of Q Fever in the United States, 2003-2004 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DIAGNOSIS AB We performed serum testing for IgG antibodies against Coxiella burnetii (phase I and phase II) and analyzed questionnaire data from 4,437 adults >= 20 years of age who participated in the National Health and Nutrition Examination Survey 2003-2004 survey cycle. National Q fever seroprevalence was determined by enzyme-linked immunosorbent assay and confirmed by using immunofluorescent antibody testing. Overall seroprevalence for Coxiella burnetii was 3.1% (95% confidence interval [CI] = 2.1-4.3%) among 4,437 adults >= 20 years of age. Coxiella burnetii age-adjusted antibody prevalence was higher for men than for women (3.8%, 95% CI = 2.7-5.2% versus 2.5%, 95% CI = 1.5-3.7%, respectively. P < 0.05). Mexican Americans had a significantly higher antibody prevalence(7.4%, 95% CI = 6.6-8.3%) than either non-Hispanic whites (2.8%, 95% CI = 1.7-4.3%) or non-Hispanic blacks (1.3%, 95% CI = 0.6-2.5%) (P < 0.001). Multivariate analysis showed that the risk for Q fever antibody positivity increased with age and was higher among persons who were foreign-born, male, and living in poverty. These findings indicate that the national seroprevalence of Q fever in the United States is higher than expected on the basis of case numbers reported to the Centers for Disease Control and Prevention from state health departments. Potential differences in risk for exposure by race/ethnicity warrant further study. C1 [Anderson, Alicia D.; Nicholson, William L.; Priestley, Rachel A.; Candee, Amanda J.; Patterson, Nicole E.; Massung, Robert F.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Kruszon-Moran, Deanna; McQuillan, Geraldine] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Anderson, AD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, 1600 Clifton Rd,Mailstop G-44, Atlanta, GA 30333 USA. EM aha5@cdc.gov; ddk0@cdc.gov; adloftis@gmail.com; gmm2@cdc.gov; wan6@cdc.gov; rnp9@cdc.gov; acandeeis@gmail.com; rfm2@cdc.gov FU Rickettsial Zoonoses Branch, CDC FX This study was supported by the Rickettsial Zoonoses Branch, CDC. NR 22 TC 47 Z9 48 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 691 EP 694 DI 10.4269/ajtmh.2009.09-0168 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000028 PM 19815888 ER PT J AU Amatre, G Babi, N Enscore, RE Ogen-Odoi, A Atiku, LA Akol, A Gage, KL Eisen, RJ AF Amatre, Gerald Babi, Nackson Enscore, Russell E. Ogen-Odoi, Asaph Atiku, Linda A. Akol, Anne Gage, Kenneth L. Eisen, Rebecca J. TI Flea Diversity and Infestation Prevalence on Rodents in a Plague-Endemic Region of Uganda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EARLY-PHASE TRANSMISSION; WESTERN USAMBARA MOUNTAINS; SOUTHWESTERN UNITED-STATES; YERSINIA-PESTIS; NEW-MEXICO; RISK; EPIDEMIOLOGY; EVOLUTION; INFECTION; DYNAMICS AB In Uganda, the West Nile region is the primary epidemiologic focus for plague. The aims of this study were to 1) describe flea-host associations within a plague-endemic region of Uganda, 2) compare flea loads between villages with or without a history of reported human plague cases and between sampling periods, and 3) determine vector loads on small mammal hosts in domestic, peridomestic, and sylvatic settings. We report that the roof rat, Rattus rattus. is the most common rodent collected in human dwellings in each of the 10 villages within the two districts sampled. These rats were commonly infested with efficient Y. pestis vectors, Xenopsylla cheopis and X. brasiliensis in Arua and Nebbi districts, respectively. In peridomestic and sylvatic areas in both districts, the Nile rat, Arvicanthus niloticus, was the most abundant rodent and hosted the highest diversity of flea species. When significant temporal differences in flea loads were detected, they were typically lower during the dry month of January. We did not detect any significant differences in small mammal abundance or flea loads between villages with our without a history of human plague, indicating that conditions during inter-epizootic periods are similar between these areas. Future studies are needed to determine whether flea abundance or species composition changes during epizootics when humans are most at risk of exposure. C1 [Enscore, Russell E.; Gage, Kenneth L.; Eisen, Rebecca J.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Enter & Vector Borne Dis, CCID CDC,Bacterial Dis Branch, Ft Collins, CO 80522 USA. [Akol, Anne] Makerere Univ, Dept Zool, Kampala, Uganda. [Amatre, Gerald; Babi, Nackson; Atiku, Linda A.] Uganda Virus Res Inst, Entebbe, Uganda. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Enter & Vector Borne Dis, CCID CDC,Bacterial Dis Branch, 3150 Rampart Rd, Ft Collins, CO 80522 USA. EM dyn2@cdc.gov NR 43 TC 23 Z9 23 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2009 VL 81 IS 4 BP 718 EP 724 DI 10.4269/ajtmh.2009.09-0104 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 502QC UT WOS:000270474000034 PM 19815894 ER PT J AU Norrgran, J Williams, TL Woolfitt, AR Solano, MI Pirkle, JL Barr, JR AF Norrgran, Jessica Williams, Tracie L. Woolfitt, Adrian R. Solano, Maria I. Pirkle, James L. Barr, John R. TI Optimization of digestion parameters for protein quantification SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE In-solution enzymatic digestion; Protein quantification; Liquid chromatography-tandem mass spectrometry (LC-MS/MS) ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MASS-SPECTROMETRY; ABSOLUTE QUANTIFICATION; ENZYMATIC DIGESTION; AMINO-ACIDS; SURFACTANT; PROTEOMICS; MIXTURES; MODEL AB We present a rapid and efficient in-solution enzymatic digestion protocol suitable for mass spectrometry-based absolute protein quantification techniques. The digestion method employs RapiGest SF (an acid-labile surfactant), an excess amount of modified trypsin (enzyme-to-substrate ratio of 2.5:1), and an incubation time of 2 h. No reduction/alkylation reagents are used. Digestion parameters were varied systematically to monitor their effect on rate and completeness of digestion. To demonstrate the general applicability of the method, the optimization was done using a viral hemagglutinin (HA) as a model protein and then applied to ricin, a potent protein toxin extracted from the castor bean (Ricinus communis). The parameters that were optimized included incubation time, concentration of RapiGest SF, enzyme-to-substrate ratio, and incubation temperature. The optimization was done by comparing the yields from two protein-specific peptides originating from two different sites of the HA protein. The analysis was performed by liquid chromatography-tandem mass spectrometry in multiple reaction monitoring mode using isotopically labeled peptide standards for quantification. (C) 2009 Published by Elsevier Inc. C1 [Norrgran, Jessica; Williams, Tracie L.; Woolfitt, Adrian R.; Solano, Maria I.; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-50, Atlanta, GA 30341 USA. EM jbarr@cdc.gov NR 35 TC 44 Z9 45 U1 2 U2 28 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 EI 1096-0309 J9 ANAL BIOCHEM JI Anal. Biochem. PD OCT 1 PY 2009 VL 393 IS 1 BP 48 EP 55 DI 10.1016/j.ab.2009.05.050 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 480JS UT WOS:000268731300007 PM 19501563 ER PT J AU Kostyal, D Horton, K Beezhold, D Lockwood, S Hamilton, RG AF Kostyal, David Horton, Kelly Beezhold, Donald Lockwood, Suzanne Hamilton, Robert G. TI LATEX AS A SIGNIFICANT SOURCE OF HEVEA BRASILIENSIS ALLERGEN EXPOSURE SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter ID DISPOSABLE MEDICAL GLOVES; NATURAL-RUBBER LATEX; HEALTH-CARE WORKERS; CROSS-REACTIVITY C1 [Kostyal, David; Horton, Kelly] Guthrie Fdn Educ & Res, Sayre, PA 18840 USA. [Beezhold, Donald] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV USA. [Lockwood, Suzanne] Amer Latex Allergy Assoc, Slinger, WI USA. [Hamilton, Robert G.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Kostyal, D (reprint author), Guthrie Fdn Educ & Res, Sayre, PA 18840 USA. EM kostyal_david@guthrie.org NR 9 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD OCT PY 2009 VL 103 IS 4 BP 354 EP 355 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 509YP UT WOS:000271055500014 PM 19852202 ER PT J AU Riddell, MA Kelly, HA Featherstone, D Rota, P AF Riddell, Michaela A. Kelly, Heath A. Featherstone, David Rota, Paul TI Laboratory Testing and Confirmation of Suspected Measles Infection Crucial in Countries That Have Eliminated Measles SO ANNALS OF EMERGENCY MEDICINE LA English DT Letter C1 [Featherstone, David] WHO, Global Measles Rubella Lab Network, CH-1211 Geneva, Switzerland. [Rota, Paul] Ctr Dis Control & Prevent, Measles Virus Sect, Atlanta, GA USA. [Riddell, Michaela A.; Kelly, Heath A.] WHO Measles Reference Lab Western Pacific Reg, Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia. RP Riddell, MA (reprint author), WHO Measles Reference Lab Western Pacific Reg, Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia. OI Riddell, Michaela/0000-0001-8852-0569 NR 4 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2009 VL 54 IS 4 BP 639 EP 640 DI 10.1016/j.annemergmed.2009.03.035 PG 2 WC Emergency Medicine SC Emergency Medicine GA 506VG UT WOS:000270804100029 PM 19769897 ER PT J AU Hanley, KW Petersen, MR Cheever, KL Luo, L AF Hanley, Kevin W. Petersen, Martin R. Cheever, Kenneth L. Luo, Lian TI N-Acetyl-S-(n-Propyl)-L-Cysteine in Urine from Workers Exposed to 1-Bromopropane in Foam Cushion Spray Adhesives SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Article DE bromide; 1-bromopropane; CAS No; 106-94-5; foam cushion; N-acetyl-S-(n-propyl)-L-cysteine; spray adhesive; urine ID LAYER DEPLETING SOLVENTS; MERCAPTURIC ACIDS; ELECTROPHILIC CHEMICALS; INHALATION EXPOSURE; S-PROPYLCYSTEINE; VINYL-CHLORIDE; TOXIC AGENTS; CANCER-RISK; RATS; 2-BROMOPROPANE AB 1-Bromopropane (1-BP) has been marketed as an alternative for ozone depleting and other solvents; it is used in aerosol products, adhesives, metal, precision, and electronics cleaning solvents. Mechanisms of toxicity of 1-BP are not fully understood, but it may be a neurological and reproductive toxicant. Sparse exposure information prompted this study using 1-BP air sampling and urinary metabolites. Mercapturic acid conjugates are excreted in urine from 1-BP metabolism involving debromination. Research objectives were to evaluate the utility of urinary N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys) for assessing exposure to 1-BP and compare it to urinary bromide [Br((-))] previously reported for these workers. Forty-eight-hour urine specimens were obtained from 30 workers at two factories where 1-BP spray adhesives were used to construct polyurethane foam seat cushions. Urine specimens were also obtained from 21 unexposed control subjects. All the workers' urine was collected into composite samples representing three time intervals: at work, after work but before bedtime, and upon awakening. Time-weighted average (TWA) geometric mean breathing zone concentrations were 92.4 and 10.5 p.p.m. for spraying and non-spraying jobs, respectively. Urinary AcPrCys showed the same trend as TWA exposures to 1-BP: higher levels were observed for sprayers. Associations of AcPrCys concentrations, adjusted for creatinine, with 1-BP TWA exposure were statistically significant for both sprayers (P < 0.05) and non-sprayers (P < 0.01). Spearman correlation coefficients for AcPrCys and Br((-)) analyses determined from the same urine specimens were highly correlated (P < 0.0001). This study confirms that urinary AcPrCys is an important 1-BP metabolite and an effective biomarker for highly exposed foam cushion workers. C1 [Hanley, Kevin W.; Petersen, Martin R.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Cheever, Kenneth L.] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Luo, Lian] Constella Grp Inc, Cincinnati, OH USA. RP Hanley, KW (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. EM KHanley@cdc.gov FU NTP; National Institute of Environmental Health Sciences (NIEHS); NIOSH [Y1-ES-9045]; Centers for Disease Control and Prevention (CDC) FX Interagency agreement between the NTP; National Institute of Environmental Health Sciences (NIEHS) and the NIOSH (NIOSH Interagency Agreement Y1-ES-9045); Centers for Disease Control and Prevention (CDC). NR 54 TC 5 Z9 9 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD OCT PY 2009 VL 53 IS 7 BP 759 EP 769 DI 10.1093/annhyg/mep051 PG 11 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA 505IA UT WOS:000270684900012 PM 19706636 ER PT J AU Ferreira, JAG Carr, JH Starling, CEF de Resende, MA Donlan, RM AF Ferreira, J. A. G. Carr, J. H. Starling, C. E. F. de Resende, M. A. Donlan, R. M. TI Biofilm Formation and Effect of Caspofungin on Biofilm Structure of Candida Species Bloodstream Isolates SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ALBICANS BIOFILMS; ANTIFUNGAL AGENTS; IN-VITRO; PERSISTER CELLS; UNITED-STATES; FLUCONAZOLE RESISTANCE; PARAPSILOSIS BIOFILMS; EFFLUX PUMPS; INFECTIONS; SUSCEPTIBILITY AB Candida biofilms are microbial communities, embedded in a polymeric matrix, growing attached to a surface, and are highly recalcitrant to antimicrobial therapy. These biofilms exhibit enhanced resistance against most antifungal agents except echinocandins and lipid formulations of amphotericin B. In this study, biofilm formation by different Candida species, particularly Candida albicans, C. tropicalis, and C. parapsilosis, was evaluated, and the effect of caspofungin (CAS) was assessed using a clinically relevant in vitro model system. CAS displayed in vitro activity against C. albicans and C. tropicalis cells within biofilms. Biofilm formation was evaluated after 48 h of antifungal drug exposure, and the effects of CAS on preformed Candida species biofilms were visualized using scanning electron microscopy (SEM). Several species-specific differences in the cellular morphologies associated with biofilms were observed. Our results confirmed the presence of paradoxical growth (PG) in C. albicans and C. tropicalis biofilms in the presence of high CAS concentrations. These findings were also confirmed by SEM analysis and were associated with the metabolic activity obtained by biofilm susceptibility testing. Importantly, these results suggest that the presence of atypical, enlarged, conical cells could be associated with PG and with tolerant cells in Candida species biofilm populations. The clinical implications of these findings are still unknown. C1 [Ferreira, J. A. G.; de Resende, M. A.] Univ Fed Minas Gerais, Dept Microbiol, BR-31270901 Belo Horizonte, MG, Brazil. [Ferreira, J. A. G.; Starling, C. E. F.] Hosp Vera Cruz, Dept Doencas Infecciosas, Belo Horizonte, MG, Brazil. [Carr, J. H.; Donlan, R. M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. RP Ferreira, JAG (reprint author), Univ Fed Minas Gerais, Dept Microbiol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil. EM jantgferr@hotmail.com NR 56 TC 39 Z9 39 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2009 VL 53 IS 10 BP 4377 EP 4384 DI 10.1128/AAC.00316-09 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496ZS UT WOS:000270020600045 PM 19546368 ER PT J AU Oberste, MS Moore, D Anderson, B Pallansch, MA Pevear, DC Collett, MS AF Oberste, M. Steven Moore, Deborah Anderson, Barbara Pallansch, Mark A. Pevear, Daniel C. Collett, Marc S. TI In Vitro Antiviral Activity of V-073 against Polioviruses SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article AB V-073, an enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC(50)) values ranging from 0.003 to 0.126 mu M. Ninety percent of the polioviruses tested were inhibited at EC(50)s of <= 0.076 mu M (MIC(90) = 32 ng/ml). V-073 is a promising antiviral candidate for the posteradication management of poliovirus incidents. C1 [Collett, Marc S.] ViroDefense Inc, Rockville, MD USA. [Oberste, M. Steven; Moore, Deborah; Anderson, Barbara; Pallansch, Mark A.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Pevear, Daniel C.] Protez Pharmaceut Inc, Malvern, PA USA. RP Collett, MS (reprint author), ViroDefense Inc, Gibbs St,Suite 529, Rockville, MD USA. EM mscollett@aol.com FU Task Force for Global Health; WHO FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 6 TC 23 Z9 24 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2009 VL 53 IS 10 BP 4501 EP 4503 DI 10.1128/AAC.00671-09 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496ZS UT WOS:000270020600063 PM 19635956 ER PT J AU Kitchel, B Sundin, DR Patel, JB AF Kitchel, Brandon Sundin, Daniel R. Patel, Jean B. TI Regional Dissemination of KPC-Producing Klebsiella pneumoniae SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID HYDROLYZING BETA-LACTAMASE; SEQUENCE TYPE 258; NEW-YORK-CITY; CARBAPENEM-RESISTANT; PSEUDOMONAS-AERUGINOSA; PLASMID; EMERGENCE AB Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to other Midwestern isolates. They were also unrelated to the dominant sequence type observed throughout the United States, multilocus sequence type 258. This could represent regional dissemination of another KPC-producing K. pneumoniae strain. C1 [Kitchel, Brandon; Patel, Jean B.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Sundin, Daniel R.] Spectrum Hlth, Grand Rapids, MI USA. RP Kitchel, B (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM bkitchel@cdc.gov NR 17 TC 25 Z9 25 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2009 VL 53 IS 10 BP 4511 EP 4513 DI 10.1128/AAC.00784-09 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496ZS UT WOS:000270020600066 PM 19687250 ER PT J AU Folster, JP Rickert, R Barzilay, EJ Whichard, JM AF Folster, Jason P. Rickert, Regan Barzilay, Ezra J. Whichard, Jean M. TI Identification of the Aminoglycoside Resistance Determinants armA and rmtC among Non-Typhi Salmonella Isolates from Humans in the United States SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter ID RIBOSOMAL-RNA METHYLASE; HIGH-LEVEL RESISTANCE; NORTH-AMERICA C1 [Folster, Jason P.] Ctr Dis Control & Prevent, CCID NCZVED DFBMD EDLB, Atlanta, GA 30333 USA. [Rickert, Regan; Barzilay, Ezra J.; Whichard, Jean M.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA 30333 USA. RP Folster, JP (reprint author), Ctr Dis Control & Prevent, CCID NCZVED DFBMD EDLB, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM gux8@cdc.gov NR 8 TC 17 Z9 22 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2009 VL 53 IS 10 BP 4563 EP 4564 DI 10.1128/AAC.00656-09 PG 2 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 496ZS UT WOS:000270020600080 PM 19596870 ER PT J AU Luquez, C Raphael, BH Maslanka, SE AF Luquez, Carolina Raphael, Brian H. Maslanka, Susan E. TI Neurotoxin Gene Clusters in Clostridium botulinum Type Ab Strains SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID TOXIN; SEQUENCE; SUBTYPES AB There is limited knowledge of the neurotoxin gene diversity among Clostridium botulinum type Ab strains. Only the sequences of the bont/A and bont/B genes in C. botulinum type Ab strain CDC1436 and the sequence of the bont/B gene in C. botulinum type Ab strain CDC588 have been reported. In this study, we sequenced the entire bont/A- and bont/B-associated neurotoxin gene clusters of C. botulinum type Ab strain CDC41370 and the bont/A gene of strain CDC588. In addition, we analyzed the organization of the neurotoxin gene clusters in strains CDC588 and CDC1436. The bont/A nucleotide sequence of strain CDC41370 differed from those of the known bont/A subtypes A1 to A4 by 2 to 7%, and the predicted amino acid sequence differed by 4% to 14%. The bont/B nucleotide sequence in strain CDC41370 showed 99.7% identity to the sequence of subtype B1. The bont/A nucleotide sequence of strain CDC588 was 99.9% identical to that of subtype A1. Although all of the C. botulinum type Ab strains analyzed contained the two sets of neurotoxin clusters, similar to what has been found in other bivalent strains, the intergenic spacing of p21-orfX1 and orfX2-orfX3 varied among these strains. The type Ab strains examined in this study had differences in their toxin gene cluster compositions and bont/A and bont/B nucleotide sequences, suggesting that they may have arisen from separate recombination events. C1 [Luquez, Carolina; Raphael, Brian H.; Maslanka, Susan E.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA. RP Luquez, C (reprint author), Ctr Dis Control & Prevent, Enter Dis Lab Branch, 1600 Clifton Rd,MS G-29, Atlanta, GA 30333 USA. EM Cluquez@cdc.gov RI luquez, carolina/C-4352-2011; OI Raphael, Brian/0000-0003-2778-2623 FU Centers for Disease Control and Prevention, Coordinating Office for Terrorism Preparedness and Emergency Response FX This publication was supported by funds made available from the Centers for Disease Control and Prevention, Coordinating Office for Terrorism Preparedness and Emergency Response. NR 20 TC 26 Z9 26 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT 1 PY 2009 VL 75 IS 19 BP 6094 EP 6101 DI 10.1128/AEM.01009-09 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 498CE UT WOS:000270113200008 PM 19684172 ER PT J AU Panuwet, P Prapamontol, T Chantara, S Thavornyuthikarn, P Bravo, R Restrepo, P Walker, RD Williams, BL Needham, LL Barr, DB AF Panuwet, Parinya Prapamontol, Tippawan Chantara, Somporn Thavornyuthikarn, Prasak Bravo, Roberto Restrepo, Paula Walker, Robert D. Williams, Bryan L. Needham, Larry L. Barr, Dana B. TI Urinary Paranitrophenol, a Metabolite of Methyl Parathion, in Thai Farmer and Child Populations SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID TANDEM MASS-SPECTROMETRY; ORGANOPHOSPHORUS PESTICIDES; QUANTIFICATION; EXPOSURE AB Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of methyl parathion in urine samples collected from 136 farmers (age 20 to 65 years) and 306 school children (age 10 to 15 years) in 2006. Participants came from two topographically different areas: one was colder and mountainous, whereas the other was alluvial with climate fluctuations depending on the monsoon season. Both children and farmers were recruited from each area. Despite methyl parathion's prohibited use in agriculture in 2004, we detected PNP in > 90% of all samples analyzed. We applied a nonparametric correlation test (PNP vs. DMP and DMTP) to determine whether the PNP found in most of the samples tested resulted from exposures to methyl parathion. DMP (Spearman's rho = 0.601 [p = 0.001] for farmers and Spearman's rho = 0.263 [p < 0.001] for children) and DMTP (Spearman's rho = 0.296 [p = 0.003] for farmers and Spearman's rho = 0.304 [p < 0.001] for children) were positively correlated with PNP, suggesting a common source for the three analytes, presumably methyl parathion or related environmental degradates. Although we found a modest correlation between the metabolites, our findings suggest that despite the prohibition, at least a portion (approximately 25% to 60%) of the PNP detected among farmers and children in Thailand may be attributed to exposure from continued methyl parathion use. C1 [Panuwet, Parinya; Bravo, Roberto; Restrepo, Paula; Walker, Robert D.; Williams, Bryan L.; Needham, Larry L.; Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Panuwet, Parinya] Chiang Mai Univ, Environm Sci Doctoral Program, Fac Sci, Chiang Mai 50200, Thailand. [Prapamontol, Tippawan] Chiang Mai Univ, Pollut & Environm Hlth Res Program, Res Inst Hlth Sci, Chiang Mai 50200, Thailand. [Chantara, Somporn; Thavornyuthikarn, Prasak] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand. RP Barr, DB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. EM dbarr@cdc.gov RI Chantara, Somporn/A-1231-2009; Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013 NR 27 TC 6 Z9 7 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD OCT PY 2009 VL 57 IS 3 BP 623 EP 629 DI 10.1007/s00244-009-9315-x PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 495WF UT WOS:000269925200022 PM 19365648 ER PT J AU Okada, S Kamb, ML Pandey, JP Philen, RM Love, LA Miller, FW AF Okada, Satoshi Kamb, Mary L. Pandey, Janardan P. Philen, Rossanne M. Love, Lori A. Miller, Frederick W. TI Immunogenetic Risk and Protective Factors for the Development of L-Tryptophan-Associated Eosinophilia-Myalgia Syndrome and Associated Symptoms SO ARTHRITIS CARE & RESEARCH LA English DT Article AB Objective. To assess L-tryptophan (LT) dose, age, sex, and immunogenetic markers as possible risk or protective factors for the development of LT-associated eosinophilia-myalgia syndrome (EMS) and related clinical findings. Methods. HLA-DRB1 and DQA1 allele typing and Gm/Km phenotyping were performed on a cohort of 94 white subjects with documented LT ingestion and standardized evaluations. Multivariate analyses compared LT dose, age, sex, and alleles among groups of subjects who ingested LT and subsequently developed surveillance criteria for EMS, developed EMS or characteristic features of EMS (EMS spectrum disorder), or developed no features of EMS (unaffected). Results. Considering all sources of LT, higher LT dose (odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8), age > 45 years (OR 3.0, 95% CI 1.0-8.8), and HLA-DRB1* 03 (OR 3.9, 95% CI 1.2-15.2), DRB1* 04 (OR 3.9, 95% CI 1.1-16.4), and DQA1* 0601 (OR 13.7, 95% CI 1.3-1.8) were risk factors for the development of EMS, whereas DRB1* 07 (OR 0.12, 95% CI 0.02-0.48) and DQA1* 0501 (OR 0.23, 95% CI 0.05-0.85) were protective. Similar risk and protective factors were seen for developing EMS following ingestion of implicated LT, except that DRB1* 03 was not a risk factor and DQA1* 0201 was an additional protective factor. EMS spectrum disorder also showed similar findings, but with DRB1* 04 being a risk factor and DRB1* 07 and DQA1* 0201 being protective. There were no differences in sex distribution, Gm/Km allotypes, or Gm/Km phenotypes among any groups. Conclusion. In addition to the xenobiotic dose and subject age, polymorphisms in immune response genes may underlie the development of certain xenobiotic-induced immune-mediated disorders, and these findings may have implications for future related epidemics. C1 [Okada, Satoshi] Ichikawa Gen Hosp, Tokyo Dent Coll, Ichikawa, Japan. [Kamb, Mary L.; Philen, Rossanne M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Pandey, Janardan P.] Univ S Carolina, Charleston, SC USA. [Love, Lori A.; Miller, Frederick W.] NIEHS, NIH, Bethesda, MD 20892 USA. [Love, Lori A.; Miller, Frederick W.] US Dept HHS, Bethesda, MD USA. RP Miller, FW (reprint author), NIEHS, Environm Autoimmun Grp, NIH 10, Room 4-2352,10 Ctr Dr,MSC 1301, Bethesda, MD 20892 USA. EM millerf@mail.nih.gov OI Miller, Frederick/0000-0003-2831-9593 FU Intramural NIH HHS [Z01 ES101074-06] NR 23 TC 8 Z9 9 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2151-464X EI 2151-4658 J9 ARTHRIT CARE RES JI Arthritis Care Res. PD OCT PY 2009 VL 61 IS 10 BP 1305 EP 1311 DI 10.1002/art.24460 PG 7 WC Rheumatology SC Rheumatology GA V26IA UT WOS:000208538100005 PM 19790128 ER PT J AU Lim, SS Drenkard, C McCune, WJ Helmick, CG Gordon, C DeGuire, P Bayakly, R Somers, EC AF Lim, S. Sam Drenkard, Cristina McCune, W. Joseph Helmick, Charles G. Gordon, Caroline DeGuire, Peter Bayakly, Rana Somers, Emily C. TI Population-Based Lupus Registries: Advancing Our Epidemiologic Understanding SO ARTHRITIS CARE & RESEARCH LA English DT Article C1 [Lim, S. Sam] Emory Univ, Sch Med, Atlanta, GA 30303 USA. [McCune, W. Joseph; Somers, Emily C.] Univ Michigan, Ann Arbor, MI 48109 USA. [Helmick, Charles G.] CDC, Atlanta, GA 30333 USA. [Gordon, Caroline] Univ Birmingham, Birmingham, W Midlands, England. [DeGuire, Peter] Michigan Dept Community Hlth, Lansing, MI USA. [Bayakly, Rana] Georgia Dept Human Resources, Atlanta, GA USA. [Somers, Emily C.] London Sch Hyg & Trop Med, London WC1, England. RP Lim, SS (reprint author), Emory Univ, Sch Med, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303 USA. EM sslim@emory.edu OI Somers, Emily/0000-0001-5234-3978 FU CDC; CDC [CDC-RFA-DP08-806, PA03022]; Genentech/Roche; Johnson Johnson; Lupus Foundation of American FX Supported in part by the CDC, and by cooperative agreement CDC-RFA-DP08-806 and earlier by cooperative agreement PA03022 from the CDC.; Dr. McCune has received consultant fees, speaking fees, and/or honoraria (less than $10,000 each) from Genentech/Roche and Johnson & Johnson. Dr. Gordon has received consultant fees, speaking fees, and/or honoraria (more than $10,000) from the CDC.; We would like to thank the Lupus Foundation of American for their support of this project. NR 16 TC 17 Z9 17 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2151-464X EI 2151-4658 J9 ARTHRIT CARE RES JI Arthritis Care Res. PD OCT PY 2009 VL 61 IS 10 BP 1462 EP 1466 DI 10.1002/art.24835 PG 5 WC Rheumatology SC Rheumatology GA V26IA UT WOS:000208538100026 PM 19790117 ER PT J AU Nater, UM Whistler, T Lonergan, W Mletzko, T Vernon, SD Heim, C AF Nater, Urs M. Whistler, Toni Lonergan, William Mletzko, Tanja Vernon, Suzanne D. Heim, Christine TI Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men SO BIOLOGICAL PSYCHOLOGY LA English DT Article DE Gene expression; Psychosocial stress; Peripheral blood mononuclear cell; Microarray; Biological pathways ID ADHESION MOLECULE EXPRESSION; ACUTE PSYCHOLOGICAL STRESS; MESSENGER-RNA; RECEPTORS; DISORDER; HORMONE AB We investigated peripheral blood mononuclear cell gene expression responses to acute psychosocial stress to identify molecular pathways relevant to the stress response. Blood samples were obtained from 10 healthy male subjects before, during and after (at 0, 30, and 60 min) a standardized psychosocial laboratory stressor. Ribonucleic acid (RNA) was extracted and gene expression measured by hybridization to a 20,000-gene microarray. Gene Set Expression Comparisons (GSEC) using defined pathways were used for the analysis. Forty-nine pathways were significantly changed from baseline to immediately after the stressor (p < 0.05), implicating cell cycle, cell signaling, adhesion and immune responses. The comparison between stress and recovery (measured 30 min later) identified 36 pathways, several involving stress-responsive signaling cascades and cellular defense mechanisms. These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress. Published by Elsevier B.V. C1 [Nater, Urs M.; Whistler, Toni; Lonergan, William; Vernon, Suzanne D.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30329 USA. [Nater, Urs M.; Mletzko, Tanja; Heim, Christine] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA. RP Whistler, T (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, 1600 Clifton Rd,MS-G41, Atlanta, GA 30329 USA. EM taw6@cdc.gov RI Whistler, Toni/A-6709-2009; Heim, Christine/A-1183-2009; Nater, Urs/J-6898-2013; OI Nater, Urs/0000-0002-2430-5090 FU NARSAD Young Investigator Award (CH); PHS [NCRR M01-RR00039]; Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC (UMN) FX This study was supported by a 2002 NARSAD Young Investigator Award (CH) and a PHS grant, NCRR M01-RR00039 (Emory University Hospital General Clinical Research Center). This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC (UMN). The funding sources did not have any role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. NR 33 TC 10 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 J9 BIOL PSYCHOL JI Biol. Psychol. PD OCT PY 2009 VL 82 IS 2 BP 125 EP 132 DI 10.1016/j.biopsycho.2009.06.009 PG 8 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA 501KI UT WOS:000270380200004 PM 19577611 ER PT J AU Collier, SA Browne, ML Rasmussen, SA Honein, MA AF Collier, Sarah A. Browne, Marilyn L. Rasmussen, Sonja A. Honein, Margaret A. CA Natl Birth Defects Prevention Stud TI Maternal Caffeine Intake during Pregnancy and Orofacial Clefts SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article; Proceedings Paper CT 48th Annual Meeting of the Teratology-Society CY JUN 28-JUL 02, 2008 CL Monterey, CA SP Teratol Soc DE caffeine; orofacial clefts; birth defects ID BIRTH-DEFECTS PREVENTION; NEURAL-TUBE DEFECTS; ORAL CLEFTS; CONGENITAL-ANOMALIES; COFFEE CONSUMPTION; IRON-ABSORPTION; UNITED-STATES; RISK; EXPOSURE; SMOKING AB BACKGROUND: Moderate caffeine intake during pregnancy is common, but little is known about its potential association with birth defects. METHODS: The National Birth Defects Prevention Study is a population-based, case-control study of major birth defects, excluding infants with single-gene disorders and chromosomal abnormalities. This analysis includes infants with cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO), excluding infants whose cleft was secondary to holoprosencephaly or amniotic band sequence. Mothers reported dietary caffeine intake from coffee, tea, sodas, and chocolate in the year before pregnancy and reported intake of medications containing caffeine during pregnancy. We assessed the association between dietary caffeine intake, frequency of consuming each type of caffeinated beverage, medications containing caffeine, and CL/P or CPO among infants born from October 1997 through December 2004. RESULTS: This analysis included 1531 infants with CL/P, 813 infants with CPO, and 5711 infants with no major birth defects (controls). Examining dietary sources among control mothers, 11%, reported consuming at least 300 mg of caffeine per day and 17% reported consuming less than 10 mg of caffeine per day; high consumption (>= 3 servings per day) was reported by 8% (coffee), 4%, (tea), and 15%, (sodas); medications containing at least 100 mg caffeine/dose were reported by less than 1%. Although some effect estimates were elevated for moderate caffeine intake from all beverages, estimates were closer to the null for high caffeine levels. Isolated CL/P was associated with use of medications containing at least 100 mg of caffeine per dose. CONCLUSIONS: Our data do not suggest an association between maternal dietary caffeine intake and orofacial clefts, but caffeine-containing medications merit further study. Birth Defects Research (Part A) 85:842849, 2009. (c) 2009 Wiley-Liss, Inc. C1 [Collier, Sarah A.; Rasmussen, Sonja A.; Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Collier, Sarah A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Browne, Marilyn L.] New York State Dept Hlth, Bur Environm & Occupat Epidemiol, Troy, NY USA. RP Honein, MA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E 86, Atlanta, GA 30333 USA. EM mrh7@cdc.gov RI Publications, NBDPS/B-7692-2013 NR 31 TC 12 Z9 12 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD OCT PY 2009 VL 85 IS 10 BP 842 EP 849 DI 10.1002/bdra.20600 PG 8 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 513UG UT WOS:000271348700005 PM 19591116 ER PT J AU Tomblyn, M Chiller, T Einsele, H Gress, R Sepkowitz, K Storek, J Wingard, JR Young, JAH Boeckh, MJ AF Tomblyn, M. Chiller, T. Einsele, H. Gress, R. Sepkowitz, K. Storek, J. Wingard, J. R. Young, J-A H. Boeckh, M. J. TI Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective PREFACE SO BONE MARROW TRANSPLANTATION LA English DT Editorial Material DE infection; prevention; guidelines ID BONE-MARROW-TRANSPLANTATION; BLOOD STEM-CELL; RESPIRATORY SYNCYTIAL VIRUS; HERPES-SIMPLEX-VIRUS; VERSUS-HOST-DISEASE; PNEUMOCYSTIS-CARINII-PNEUMONIA; HUMAN-IMMUNODEFICIENCY-VIRUS; INTENSIVE-CARE-UNIT; HEPATITIS-B-VIRUS; RESISTANT STAPHYLOCOCCUS-AUREUS C1 [Tomblyn, M.] Univ Minnesota, Dept Hematol Oncol & Transplantat, Minneapolis, MN USA. [Chiller, T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Einsele, H.] Univ Klin Wurzburg, Med Klin & Poliklin 2, Wurzburg, Germany. [Gress, R.] NIH, Bethesda, MD 20892 USA. [Sepkowitz, K.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Storek, J.] Univ Calgary, Dept Med Oncol Microbiol & Infect Dis, Calgary, AB, Canada. [Wingard, J. R.] Univ Florida, Dept Hematol & Oncol, Gainesville, FL USA. [Young, J-A H.] Univ Minnesota, Div Infect Dis, Minneapolis, MN USA. [Boeckh, M. J.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. RP Tomblyn, M (reprint author), H Lee Moffitt Canc Ctr & Res Inst, 12902 Magnolia Dr FOB 3, Tampa, FL 33612 USA. EM marcie.tomblyn@moffitt.org RI Young, Jo-Anne/G-2617-2013 OI Young, Jo-Anne/0000-0003-4182-341X NR 774 TC 96 Z9 98 U1 2 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD OCT PY 2009 VL 44 IS 8 BP 453 EP + DI 10.1038/bmt.2009.254 PG 34 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA 512KJ UT WOS:000271247300001 PM 19861977 ER PT J AU Marr, KA Bow, E Chiller, T Maschmeyer, G Ribaud, P Segal, B Steinbach, W Wingard, JR Nucci, M AF Marr, K. A. Bow, E. Chiller, T. Maschmeyer, G. Ribaud, P. Segal, B. Steinbach, W. Wingard, J. R. Nucci, M. TI Fungal infection prevention after hematopoietic cell transplantation SO BONE MARROW TRANSPLANTATION LA English DT Article DE fungus; infections; hematopoietic cell transplantation C1 [Marr, K. A.] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA. [Bow, E.] Univ Manitoba, Haematol Program, Winnipeg, MB, Canada. [Chiller, T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Maschmeyer, G.] Klinikum Ernst Von Bergmann, Ctr Hematol Oncol & Radiotherapy, Potsdam, Germany. [Ribaud, P.] Hop St Louis, Paris, France. [Segal, B.] Roswell Pk Canc Inst, Div Infect Dis, Buffalo, NY 14263 USA. [Steinbach, W.] Duke Univ, Med Ctr, Durham, NC USA. [Wingard, J. R.] Univ Florida, Dept Hematol & Oncol, Gainesville, FL USA. [Nucci, M.] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. RP Marr, KA (reprint author), Johns Hopkins Univ, Dept Med, Sch Med, 720 Rutland Ave,Ross 1064, Baltimore, MD 21205 USA. EM marrki@ohsu.edu RI Nucci, Marcio/G-4515-2012 OI Nucci, Marcio/0000-0003-4867-0014 NR 0 TC 25 Z9 26 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD OCT PY 2009 VL 44 IS 8 BP 483 EP 487 DI 10.1038/bmt.2009.259 PG 5 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA 512KJ UT WOS:000271247300006 PM 19861982 ER PT J AU Gea-Banacloche, J Masur, H da Cuhna, CA Chiller, T Kirchoff, L Shaw, P Tomblyn, M Cordonnier, C AF Gea-Banacloche, J. Masur, H. da Cuhna, C. Arns Chiller, T. Kirchoff, L. Shaw, P. Tomblyn, M. Cordonnier, C. TI Regionally limited or rare infections: prevention after hematopoietic cell transplantation SO BONE MARROW TRANSPLANTATION LA English DT Article DE Tb; PCP; hematopoietic cell transplantation C1 [Gea-Banacloche, J.; Masur, H.] NCI, NIH, Bethesda, MD 20892 USA. [da Cuhna, C. Arns] Univ Fed Parana, BR-80060000 Curitiba, Parana, Brazil. [Chiller, T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kirchoff, L.] Univ Iowa, Dept Med, Iowa City, IA 52242 USA. [Shaw, P.] Childrens Hosp Westmead, Sydney, NSW, Australia. [Tomblyn, M.] Univ Minnesota, Dept Hematol Oncol & Transplantat, Minneapolis, MN USA. [Cordonnier, C.] Hop Henri Mondor, Dept Hematol, F-94010 Creteil, France. RP Gea-Banacloche, J (reprint author), NCI, NIH, Bethesda, MD 20892 USA. EM banacloj@mail.nih.gov; marcie.tomblyn@moffitt.org NR 0 TC 14 Z9 15 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD OCT PY 2009 VL 44 IS 8 BP 489 EP 494 DI 10.1038/bmt.2009.260 PG 6 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA 512KJ UT WOS:000271247300007 PM 19861983 ER PT J AU Grummer-Strawn, LM Shealy, KR AF Grummer-Strawn, Laurence M. Shealy, Katherine R. TI Progress in Protecting, Promoting, and Supporting Breastfeeding: 1984-2009 SO BREASTFEEDING MEDICINE LA English DT Article; Proceedings Paper CT 1st Annual Summit on Breastfeeding CY JUN 11-12, 2009 CL Washington, DC ID MATERNITY-CARE PRACTICES; UNITED-STATES AB The 1984 Surgeon General's Workshop on Breastfeeding delineated six priority areas for action to protect, promote, and support breastfeeding. In this article, we examine trends in breastfeeding behaviors and recall key events and actions that shaped these behaviors over the past 25 years. We examine progress in breastfeeding support through workplaces, public education, professional education, health system changes, support services, and research. Rates of initiation of breastfeeding more than doubled from a nadir of only 26.5% in 1970 to 61.9% in 1982. Initiation fell to 51.5% in 1990, but has risen almost monotonically since then to 74.2% in 2005. Trends in breastfeeding at 6 months have paralleled initiation trends. Black-white disparities have narrowed for breastfeeding initiation but not for continuation to 6 months. Considerable progress in breastfeeding support has been seen over the past 25 years, with more employers allowing women time and space to express milk at work, more states enacting legislation to ensure that accommodations are made for employed women and protect the right to breastfeed in public, more opportunities for physician education on breastfeeding, expansion of professional lactation services, and substantial increases in the amount of research on breastfeeding. However, only 21.4% of babies are breastfed for a year, and only 11.9% exclusively breastfeed for 6 months. Only 2% of babies are born in facilities that meet international standards of care, and 74% of employers do not offer lactation rooms or accommodations for breastfeeding. Thus, in spite of considerable progress, significant gaps remain in protecting, promoting, and supporting breastfeeding. C1 [Grummer-Strawn, Laurence M.; Shealy, Katherine R.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Grummer-Strawn, LM (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K25, Atlanta, GA 30341 USA. EM lxg8@cdc.gov NR 48 TC 20 Z9 23 U1 1 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1556-8253 J9 BREASTFEED MED JI Breastfeed. Med. PD OCT PY 2009 VL 4 SU 1 BP S31 EP S39 DI 10.1089/bfm.2009.0049 PG 9 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 585AW UT WOS:000276797700008 PM 19827921 ER PT J AU Saydah, S Ballard-Barbash, R Potischman, N AF Saydah, Sharon Ballard-Barbash, Rachel Potischman, Nancy TI Association of metabolic syndrome with insulin-like growth factors among adults in the US SO CANCER CAUSES & CONTROL LA English DT Article DE Insulin-like growth factors; Metabolic syndrome; NHANES ID FACTOR BINDING PROTEIN-1; ISCHEMIC-HEART-DISEASE; FACTOR-I; SERUM-LEVELS; IGF-I; GLUCOSE-TOLERANCE; COLORECTAL-CANCER; PROSTATE-CANCER; BREAST-CANCER; BODY-MASS AB Objective To examine the association of insulin-like growth factors (IGFs) with metabolic syndrome in a nationally representative sample. Methods We used data from the Third National Health and Nutrition Examination Survey. Analysis is based on participants who provided a fasting blood sample and were aged 20 years and older (n = 5,903). Participants were classified by a number of risk factors for metabolic syndrome and stratified by diabetes status. Results Each of the components of metabolic syndrome (increased waist circumference, higher triglycerides, lower HDL cholesterol, higher blood pressure, higher fasting glucose and diabetes) was each associated with lower levels of IGF-I, IGF-BP3 and the Ratio IGF-I/IGF-BP3. Each of the metabolic syndrome components was also associated with higher levels of insulin. Participants with 3-5 components of metabolic syndrome had significantly lower IGF-I and higher IGF-BP3 levels compared to adults with 1-2 components or 0 components, after adjustment for potential confounders. Participants with diabetes had lower levels of IGF-I and IGF-BP3, and higher levels of insulin, regardless of the number of metabolic syndrome components. Conclusion These findings may prove useful to an understanding of the role of IGF-I in human disease, in C1 [Saydah, Sharon] Ctr Dis Control & Prevent, Div Diabet Translat, Hyattsville, MD 20782 USA. [Ballard-Barbash, Rachel; Potischman, Nancy] NCI, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. RP Saydah, S (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM ssaydah@cdc.gov NR 44 TC 15 Z9 15 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD OCT PY 2009 VL 20 IS 8 BP 1309 EP 1316 DI 10.1007/s10552-009-9351-x PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 505YJ UT WOS:000270737900008 PM 19415508 ER PT J AU Sjodin, A Papke, O McGahee, E Focant, JF Jones, RS Pless-Mulloli, T Toms, LML Herrmann, T Muller, J Needham, LL Patterson, DG AF Sjodin, Andreas Papke, Olaf McGahee, Ernest Focant, Jean-Francois Jones, Richard S. Pless-Mulloli, Tanja Toms, Leisa-Maree Leontjew Herrmann, Thomas Mueller, Jochen Needham, Larry L. Patterson, Donald G., Jr. TI Response to "An assessment of the human health risks from exposure to polybrominated diphenyl ethers (PBDEs) in house dust" by Marek Banasik et al. SO CHEMOSPHERE LA English DT Letter C1 [Sjodin, Andreas; McGahee, Ernest; Jones, Richard S.; Needham, Larry L.; Patterson, Donald G., Jr.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Papke, Olaf; Herrmann, Thomas] ERGO Res, D-22305 Hamburg, Germany. [Focant, Jean-Francois] Univ Liege, CART, Mass Spectrometry Lab, Dept Chem, B-4000 Liege, Belgium. [Pless-Mulloli, Tanja] Newcastle Univ, Sch Populat & Hlth Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. [Toms, Leisa-Maree Leontjew; Mueller, Jochen] Univ Queensland, Natl Res Ctr Environm Toxicol, Coopers Plains, Qld 4108, Australia. RP Sjodin, A (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy, Atlanta, GA 30341 USA. EM asjodin@cdc.gov RI Toms, Leisa-Maree/C-9530-2009; Needham, Larry/E-4930-2011; Mueller, Jochen/C-6241-2008; Sjodin, Andreas/F-2464-2010; OI Toms, Leisa-Maree/0000-0002-1444-1638; Mueller, Jochen/0000-0002-0000-1973 NR 4 TC 0 Z9 0 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2009 VL 77 IS 5 BP 706 EP 707 DI 10.1016/j.chemosphere.2009.08.019 PG 2 WC Environmental Sciences SC Environmental Sciences & Ecology GA 515DB UT WOS:000271445700017 ER PT J AU Crocker, D Brown, C Moolenaar, R Moorman, J Bailey, C Mannino, D Holguin, F AF Crocker, Deidre Brown, Clive Moolenaar, Ronald Moorman, Jeanne Bailey, Cathy Mannino, David Holguin, Fernando TI Racial and Ethnic Disparities in Asthma Medication Usage and Health-Care Utilization Data From the National Asthma Survey SO CHEST LA English DT Article ID CHILDHOOD ASTHMA; UNITED-STATES; INHALED STEROIDS; AFRICAN-AMERICAN; CHILDREN; RACE; POLYMORPHISMS; GUIDELINES; SEVERITY; PREVALENCE AB Background: Despite the availability of effective treatment, minority children continue to experience disproportionate morbidity from asthma. Our objective was to identify and characterize racial and ethnic disparities in health-care utilization and medication usage among US children with asthma in a large multistate asthma survey. Methods: We analyzed questions from the 2003-2004 four-state sample of the National Asthma Survey to assess symptom control, medication use, and health-care utilization among white, black, and Hispanic children < 18 years old with current asthma who were residing in Alabama, California, Illinois, or Texas. Results: Of the 1,485 children surveyed, 55% were white, 25% were Hispanic, and 20% were black. Twice as many black children had asthma-related ED visits (39% vs 18%, respectively; p < 0.001) and hospitalizations (12% vs 5%, respectively; p = 0.02) compared with white children. Significantly fewer black and Hispanic children reported using inhaled corticosteroids (ICSs) in the past 3 months (21% and 22%, respectively) compared to white children (33%; p = 0.001). Additionally, 26% of black children and 19% of Hispanic children reported receiving a daily dose of a short-acting P-agonist compared with 12% of white children (p = 0.001). ED visits were positively correlated with short-acting P-agonist use and were negatively correlated with ICS use when stratified by race/ethnicity. Conclusions: Children with asthma in this large, multistate survey showed a dramatic under-use of ICSs. Black and Hispanic children compared with white children had more indicators of poorly controlled asthma, including increased emergency, health-care utilization, more daily rescue medication use, and lower use of JCSs, regardless of symptom control. (CHEST 2009; 136:1063-1071) C1 [Crocker, Deidre; Moorman, Jeanne; Bailey, Cathy] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. [Brown, Clive] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Moolenaar, Ronald] Ctr Dis Control & Prevent, Div Global Publ Hlth Capac Dev, Atlanta, GA USA. [Mannino, David] Univ Kentucky, Div Pulm & Crit Care Med, Lexington, KY USA. [Holguin, Fernando] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. RP Crocker, D (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F-58, Chamblee, GA 30341 USA. EM dvj4@cdc.gov OI Mannino, David/0000-0003-3646-7828 FU Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, CA FX This study was funded by Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, CA. NR 42 TC 59 Z9 59 U1 0 U2 5 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2009 VL 136 IS 4 BP 1063 EP 1071 DI 10.1378/chest.09-0013 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 507LR UT WOS:000270855500022 PM 19567492 ER PT J AU Byrd, KK Holman, RC Bruce, MG Hennessy, TW Wenger, JD Bruden, DL Haberling, DL Steiner, C Cheek, JE AF Byrd, Kathy K. Holman, Robert C. Bruce, Michael G. Hennessy, Thomas W. Wenger, Jay D. Bruden, Dana L. Haberling, Dana L. Steiner, Claudia Cheek, James E. TI Methicillin-Resistant Staphylococcus aureus-Associated Hospitalizations among the American Indian and Alaska Native Population SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID INFECTIOUS-DISEASE HOSPITALIZATIONS; UNITED-STATES; BACTEREMIA AB Background. American Indians and Alaska Natives (AI/ANs) have had documented outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) infection but, to our knowledge, no studies have examined MRSA infection among this population nationally. We describe MRSA-associated hospitalizations among the similar to 1.6 million AI/ANs who receive care at Indian Health Service health care facilities nationwide. Methods. We used hospital discharge data from the Indian Health Service National Patient Information Reporting System to determine the rate of MRSA-associated hospitalizations among AI/ANs who used Indian Health Service health care in 1996-2005 and in the comparison periods 1996-1998 and 2003-2005. Hospitalization rates among AI/ANs were examined by year, age group, sex, and region. MRSA-associated diagnoses were also examined. Rate comparisons were performed using Poisson regression analysis. Comparison of rates to those of the general United States population was made for 2003-2005 by means of the Nationwide Inpatient Sample. Results. Between comparison periods, the rate of MRSA-associated hospitalization increased from 4.6 to 50.6 hospitalizations per 100,000 AI/ANs (P<.01), with increases in both sexes, all age groups, and all regions. By 2005, MRSA was the causative organism for the majority (52%) of all S. aureus-associated hospitalizations. The most common associated diagnosis was skin and soft-tissue infection, which accounted for 59% of MRSA-associated diagnoses. In 2003-2005, the age-adjusted rate among AI/ANs was 58.8 hospitalizations per 100,000 persons, compared with 84.7 hospitalizations per 100,000 persons in the general US population. Conclusions. MRSA-associated hospitalizations have increased significantly among AI/ANs served by Indian Health Service health care facilities. Clinicians should have a high index of suspicion for MRSA infection in AI/ANs, especially in those with a diagnosis of skin and soft-tissue infection. C1 [Byrd, Kathy K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Appl Publ Hlth Training, Epidemiol Program Off,CDC,USDHHS, Atlanta, GA USA. [Holman, Robert C.; Haberling, Dana L.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, CDC,USDHHS, Atlanta, GA USA. [Bruce, Michael G.; Hennessy, Thomas W.; Wenger, Jay D.; Bruden, Dana L.] CDC, Div Emerging Infect & Surveillance Syst, Natl Ctr Preparedness Detect & Control Infect Dis, USDHHS, Anchorage, AK USA. [Steiner, Claudia] Agcy Healthcare Res & Qual, Ctr Delivery Org & Markets, Healthcare Cost & Utilizat Project, Rockville, MD USA. Indian Hlth Serv, Div Epidemiol & Prevent, Off Publ Hlth Support, USDHHS, Albuquerque, NM USA. RP Byrd, KK (reprint author), 1600 Clifton Rd NE,Mailstop G-37, Atlanta, GA 30333 USA. EM gdn8@cdc.gov NR 23 TC 14 Z9 14 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 2009 VL 49 IS 7 BP 1009 EP 1015 DI 10.1086/605560 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 492PX UT WOS:000269672300004 PM 19725783 ER PT J AU Christensen, KLY Holman, RC Steiner, CA Sejvar, JJ Stoll, BJ Schonberger, LB AF Christensen, Krista L. Yorita Holman, Robert C. Steiner, Claudia A. Sejvar, James J. Stoll, Barbara J. Schonberger, Lawrence B. TI Infectious Disease Hospitalizations in the United States SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID STAPHYLOCOCCUS-AUREUS INFECTIONS; OLDER-ADULTS; US CHILDREN; TRENDS; MORTALITY; POPULATION; OUTBREAK; INFANTS AB Background. Infectious diseases (IDs) cause widespread morbidity and mortality. We describe the epidemiology of ID hospitalizations in the United States with use of a nationally representative database. Methods. First-listed ID hospitalizations in the United States were analyzed using the Nationwide Inpatient Sample for 1998-2006. Hospitalization rates were calculated overall for IDs and for specific ID groups. Results. An estimated 40,085,978 (standard error, 255,418) hospitalizations with a first-listed ID occurred during 1998-2006, for an age-adjusted hospitalization rate of 154.4 (95% confidence interval, 153.3-155.5) hospitalizations per 10,000 persons. The rate increased slightly over the study period (152.5 [95% confidence interval, 149.6-155.4] in 1998 vs 162.2 [95% confidence interval, 158.7-165.5] in 2006); an increase was seen for both sexes, for older patients, and for Hispanic patients. Among those aged 5-39 years, female patients had a significantly higher hospitalization rate than did male patients; male patients had higher rates among the youngest children and adults aged >= 40 years. Approximately 4.5 million hospital days and $865 billion in hospital charges were associated with primary ID hospitalizations over the study period. Lower respiratory tract infections were the most commonly listed ID (34.4%), followed by kidney, urinary tract, and bladder infections; cellulitis; and abdominal and rectal infections. Conclusions. The ID hospitalization rate increased during 1998-2006, reflecting an increase in ID hospitalizations among adults aged >= 30 years, particularly older adults. Differences in trends and patterns of ID hospitalizations were noted by sex, age group, and race. Lower respiratory tract infections accounted for the largest proportion of ID hospitalizations. Future efforts should focus on preventive measures and improving early interventions for IDs. C1 [Christensen, Krista L. Yorita; Holman, Robert C.; Sejvar, James J.; Schonberger, Lawrence B.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, US Dept Hlth & Human Serv, Atlanta, GA 30333 USA. [Stoll, Barbara J.] Emory Sch Med, Dept Pediat, Atlanta, GA USA. [Steiner, Claudia A.] US Dept Hlth & Human Serv, Healthcare Cost & Utilizat Project, Ctr Delivery Org & Markets, Agcy Healthcare Res & Qual, Rockville, MD USA. RP Christensen, KLY (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, US Dept Hlth & Human Serv, MS A-39, Atlanta, GA 30333 USA. EM KYorita@cdc.gov NR 32 TC 59 Z9 60 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 2009 VL 49 IS 7 BP 1025 EP 1035 DI 10.1086/605562 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 492PX UT WOS:000269672300007 PM 19708796 ER PT J AU Ortega-Sanchez, IR Zell, E Cohn, A Messonnier, N AF Ortega-Sanchez, Ismael R. Zell, Elizabeth Cohn, Amanda Messonnier, Nancy TI Underestimation of Invasive Meningococcal Disease Case Fatality Rates Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Ortega-Sanchez, Ismael R.; Zell, Elizabeth; Cohn, Amanda; Messonnier, Nancy] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Ortega-Sanchez, IR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE MS A-34, Atlanta, GA 30333 USA. EM IOrtegaSanchez@cdc.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 2009 VL 49 IS 7 BP 1137 EP 1138 DI 10.1086/605600 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 492PX UT WOS:000269672300029 ER PT J AU Goldsmith, CS Miller, SE AF Goldsmith, Cynthia S. Miller, Sara E. TI Modern Uses of Electron Microscopy for Detection of Viruses SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Review ID PAPILLOMAVIRUS-LIKE PARTICLES; HANTAVIRUS PULMONARY SYNDROME; RENAL-TRANSPLANT RECIPIENTS; ACUTE RESPIRATORY SYNDROME; 3-DIMENSIONAL RECONSTRUCTION; HEMORRHAGIC-FEVER; DISORDERED SPECIMENS; INFECTIOUS AGENTS; MONKEYPOX VIRUS; UNITED-STATES AB Electron microscopy, considered by some to be an old technique, is still on the forefront of both clinical viral diagnoses and viral ultrastructure and pathogenesis studies. In the diagnostic setting, it is particularly valuable in the surveillance of emerging diseases and potential bioterrorism viruses. In the research arena, modalities such as immunoelectron microscopy, cryo-electron microscopy, and electron tomography have demonstrated how viral structural components fit together, attach to cells, assimilate during replication, and associate with the cellular machinery during replication and egression. These studies provide information for treatment and vaccine strategies. C1 [Goldsmith, Cynthia S.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. [Miller, Sara E.] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA. RP Goldsmith, CS (reprint author), Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. EM cgoldsmith@cdc.gov NR 100 TC 47 Z9 50 U1 3 U2 25 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD OCT PY 2009 VL 22 IS 4 BP 552 EP + DI 10.1128/CMR.00027-09 PG 13 WC Microbiology SC Microbiology GA 505RG UT WOS:000270711700002 PM 19822888 ER PT J AU Curtis, KM Peterson, HB d'Arcangues, C AF Curtis, Kathryn M. Peterson, Herbert B. d'Arcangues, Catherine TI Keeping evidence-based recommendations up to date: the World Health Organization's global guidance for family planning SO CONTRACEPTION LA English DT Editorial Material ID CLINICAL-PRACTICE GUIDELINES; QUALITY C1 [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Peterson, Herbert B.] Univ N Carolina, Sch Publ Hlth, Dept Maternal & Child Hlth, Chapel Hill, NC 27599 USA. [Peterson, Herbert B.] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Chapel Hill, NC 27599 USA. [d'Arcangues, Catherine] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. EM kmc6@cdc.gov NR 10 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 323 EP 324 DI 10.1016/j.contraception.2009.04.009 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700001 PM 19751853 ER PT J AU Kapp, N Curtis, KM AF Kapp, Nathalie Curtis, Kathryn M. TI Intrauterine device insertion during the postpartum period: a systematic review SO CONTRACEPTION LA English DT Review DE Intrauterine device; Postpartum contraception; Intrauterine device insertion ID IMMEDIATE POSTPARTUM; IUD INSERTION; CLINICAL-OUTCOMES; FOLLOW-UP AB Background: Insertion of an intrauterine device (IUD) at different times or by different routes during the postpartum period may increase the risk of complications. Methods: We searched Medline, Lilacs and Cochrane Collaboration databases for articles in any language, between database inception until December 2008, which compared outcomes of postpartum IUD insertion time intervals. Search terms included postpartum, puerperium, postcesarean delivery, cesarean section, IUD(s), IUCD(s), intrauterine device(s) and insertion. Results: From 297 articles, we identified 15 for inclusion in this review: all studies examined the outcomes from copper IUD insertions within the postpartum time period compared to other time intervals or compared routes (vaginal or via hysterotomy) of postpartum insertion. No studies of levonorgestrel IUDs were identified. Immediate IUD insertion (within 10 min of placental delivery) was safe when compared with later postpartum time periods and interval insertion. Immediate postpartum IUD insertion demonstrated lower expulsion rates when compared with delayed postpartum insertion but with higher rates than interval insertion. Immediate insertion following cesarean delivery demonstrated lower expulsion rates than immediate insertion following vaginal delivery. Conclusion: Poor to fair quality evidence from 15 articles demonstrated no increase in risk of complications among women who had an IUD inserted during the postpartum period; however, some increase in expulsion rates occurred with delayed postpartum insertion when compared to immediate insertion and with immediate insertion when compared to interval insertion. Postplacental placements during cesarean delivery are associated with lower expulsion rates than postplacental vaginal insertions, without increasing rates of postoperative complications. (C) 2009 Elsevier Inc. All rights reserved. C1 [Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Kapp, N (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM kappn@who.int FU Department of Reproductive Health and Research; Centers for Disease Control and Prevention; US Agency for International Development; National Institute of Child Health and Human Development, USA FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization, the Centers for Disease Control and Prevention, the US Agency for International Development and the National Institute of Child Health and Human Development, USA. NR 19 TC 73 Z9 74 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 327 EP 336 DI 10.1016/j.contraception.2009.03.024 PG 10 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700003 PM 19751855 ER PT J AU Culwell, KR Curtis, KM AF Culwell, Kelly R. Curtis, Kathryn M. TI Use of contraceptive methods by women with current venous thrombosis on anticoagulant therapy: a systematic review SO CONTRACEPTION LA English DT Review DE Contraceptives; Venous thrombosis; Anticoagulants ID INTRAUTERINE SYSTEM; MENORRHAGIA; RISK; THROMBOEMBOLISM; WARFARIN; SURGERY; COMPLICATIONS; PROGESTAGENS; MANAGEMENT; DISORDERS AB Background: As nearly all women with venous thromboembolism (VTE) will be treated with anticoagulant therapy, it is important to consider how anticoagulation affects the safety of contraceptive use. Study design: We conducted a systematic review of the literature regarding use of contraceptive methods in women with current VTE on anticoagulant therapy. Due to the limited direct evidence that was identified, we expanded our search to include women on anticoagulant therapy for indications other than VTE and women with bleeding disorders. Results: Six articles met our inclusion criteria. Three observational studies found the levonorgestrel-releasing IUD (LNG-IUD) was an effective treatment for menorrhagia for women on anticoagulation therapy or with bleeding disorders. Prevention of recurrent hemorrhagic ovarian cysts was seen in women on chronic anticoagulation treated with depot-medroxyprogesterone acetate (DMPA) in one small observational study. Among women with bleeding disorders, no complications were seen in 16 women with placement of the LNG-IUD. One pharmacokinetic study found no statistically significant interaction between combined oral contraceptives and warfarin. Other than one case report, no evidence was found regarding the risk of recurrent thrombosis in women on anticoagulation therapy using a contraceptive method. Conclusion: The majority of studies in this review examined treatment effects of the LNG-IUD or DMPA on complications of anticoagulation and found overall beneficial effects of their use in these circumstances. Minimal evidence in women with inherited bleeding disorders suggests that insertion of the LNG-IUD does not pose major bleeding risks in these women with appropriate management. (C) 2009 Elsevier Inc. All rights reserved. C1 [Culwell, Kelly R.] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Culwell, KR (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM culwellk@who.int FU Department of Reproductive Health and Research; Centers for Disease Control and Prevention; Association of Schools of Public Health; United States Agency for International Development; National Institute of Child Health and Human Development in the USA FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization, the Centers for Disease Control and Prevention, the Association of Schools of Public Health, the United States Agency for International Development and the National Institute of Child Health and Human Development in the USA. NR 24 TC 19 Z9 19 U1 3 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 337 EP 345 DI 10.1016/j.contraception.2009.04.008 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700004 PM 19751856 ER PT J AU Curtis, KM Ravi, A Gaffield, ML AF Curtis, Kathryn M. Ravi, Anita Gaffield, Mary Lyn TI Progestogen-only contraceptive use in obese women SO CONTRACEPTION LA English DT Review DE Hormonal contraception; Obesity; Adolescents ID DEPOT-MEDROXYPROGESTERONE ACETATE; WEIGHT; ADOLESCENTS AB Background: The objective of this systematic review is to determine whether obese women who use progestogen-only contraceptives are more likely to experience weight gain or serious adverse events as compared to nonobese users. Study Design: We searched PubMed for all articles (in all languages) published in peer-reviewed journals from database inception through October 2008, for evidence relevant to obesity and progestogen-only contraceptives. We used standard abstract forms and grading systems to summarize and assess the quality of the evidence. Results: From 579 articles, we identified nine studies fitting our selection criteria. Evidence from five studies suggests that among adult women, baseline weight or body mass index is not associated with weight gain among depot medroxyprogesterone acetate (DMPA) users (Level II-2, Fair). Evidence from three studies suggests that among adolescent women, overweight or obese DMPA users may gain more weight than normal weight DMPA users or overweight/obese nonusers (Level II-2, Fair). Evidence from one small study of Norplant users showed no differences in weight gain by baseline weight (Level II-3, Poor). We did not identify studies of other progestogen-only contraceptive methods that examined weight change by baseline weight, nor did we identify studies that reported on any serious adverse events by baseline weight. Conclusions: Adolescent DMPA users who are obese may gain more weight than normal weight users. This observation was not seen in adult DMPA users or adolescent Norplant users. Published by Elsevier Inc. C1 [Curtis, Kathryn M.; Ravi, Anita] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Gaffield, Mary Lyn] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland. RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. EM kmc6@cdc.gov FU World Health Organization; Centers for Disease Control and Prevention; US Agency for International Development; National Institute of Child Health and Human Development FX This review was supported by resources from the World Health Organization, the Centers for Disease Control and Prevention, US Agency for International Development and the National Institute of Child Health and Human Development. NR 14 TC 12 Z9 12 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 346 EP 354 DI 10.1016/j.contraception.2009.04.006 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700005 PM 19751857 ER PT J AU Gaffield, ME Kapp, N Ravi, A AF Gaffield, Mary E. Kapp, Nathalie Ravi, Anita TI Use of combined oral contraceptives post abortion SO CONTRACEPTION LA English DT Review DE Combined oral contraceptive; Medical abortion; Surgical abortion; Safety ID BLOOD-LOSS; MIFEPRISTONE; PROSTAGLANDIN; MISOPROSTOL; OVULATION; RETURN; WOMEN; PILLS AB Background: Providing combined oral contraceptives (COCs) following surgical or medical induced abortion offers women an opportune moment to initiate a reliable contraceptive method. Study Design: We conducted a systematic review, searching MEDLINE and The Cochrane Library for articles in any language concerning COC use following spontaneous, induced (medical or surgical) or septic abortion, from 1966 through June 2008. Seven articles were identified and evaluated using the United States Preventive Services Task Force system. Results: Immediate COC initiation after first-trimester medical or surgical induced abortion did not increase side effects or prolong vaginal bleeding compared with use of a placebo, copper-bearing intrauterine device (IUD), nonhormonal contraceptive method or COC initiation at a later time. Initiating COCs after first-trimester surgical abortion produced small increases in coagulation parameters compared with IUD use; although they are statistically significant, their clinical relevance is unlikely. No study examined second-trimester induced or spontaneous abortion, or septic abortion. Conclusions: Evidence shows that COCs can be safely initiated immediately following surgical and medical abortion in the first-trimester of pregnancy. (C) 2009 Elsevier Inc. All rights reserved. C1 [Gaffield, Mary E.; Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Ravi, Anita] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Gaffield, ME (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM gaffieldm@who.int FU Department of Reproductive Health and Research at the World Health Organization in Geneva, Switzerland; Centers for Disease Control and Prevention; Association of Schools of Public Health; United States Agency for International Development; National Institute of Child Health and Human Development, in the USA FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization in Geneva, Switzerland, and from the Centers for Disease Control and Prevention, the Association of Schools of Public Health, the United States Agency for International Development and the National Institute of Child Health and Human Development, in the USA. NR 21 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 355 EP 362 DI 10.1016/j.contraception.2009.04.005 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700006 PM 19751858 ER PT J AU Gaffield, ME Kapp, N Curtis, KM AF Gaffield, Mary E. Kapp, Nathalie Curtis, Kathryn M. TI Combined oral contraceptive and intrauterine device use among women with gestational trophoblastic disease SO CONTRACEPTION LA English DT Review DE Gestational trophoblastic disease; Postmolar trophoblastic disease; Combined oral contraceptives; Intrauterine devices; Safety ID HUMAN CHORIONIC-GONADOTROPIN; HORMONAL CONTRACEPTION; HYDATIDIFORM MOLE; REGRESSION; TUMOR AB Background: Women diagnosed with gestational trophoblastic disease (GTD) need safe and effective contraception because they are advised to delay a subsequent pregnancy. Study Design: We searched MEDLINE and The Cochrane Library for articles in any language on use of combined oral contraceptives (COC), copper-bearing or levonorgestrel-releasing IUDs among women with benign or malignant GTD, from database inception through November 2008. One review and nine articles were identified and evaluated. Results: Incidence of postmolar trophoblastic disease was lower among COC users compared with nonusers in six studies, but higher among COC users in three studies. Five studies reported shorter human chorionic gonadotropin (hCG) regression duration among COC users compared with other methods. Development of postmolar trophoblastic disease did not differ significantly among IUD users compared with COC users or nonusers in three studies. Conclusions: Evidence shows that postmolar trophoblastic disease risk does not increase among women using COCs or an IUD following molar pregnancy evacuation compared with use of other contraceptive methods or no method. (C) 2009 Elsevier Inc. All rights reserved. C1 [Gaffield, Mary E.; Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Gaffield, ME (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM gaffieldm@who.int FU Department of Reproductive Health and Research at the World Health Organization in Geneva, Switzerland; Centers for Disease Control and Prevention; Association of Schools of Public Health; United States Agency for International Development; National Institute of Child Health and Human Development, in the USA FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization in Geneva, Switzerland, the Centers for Disease Control and Prevention, the Association of Schools of Public Health, the United States Agency for International Development and the National Institute of Child Health and Human Development, in the USA. NR 19 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 363 EP 371 DI 10.1016/j.contraception.2009.03.022 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700007 PM 19751859 ER PT J AU Gaffield, ME Culwell, KR Ravi, A AF Gaffield, Mary E. Culwell, Kelly R. Ravi, Anita TI Oral contraceptives and family history of breast cancer SO CONTRACEPTION LA English DT Review DE Oral contraceptives; Family history; Breast cancer; Epidemiology ID COLLABORATIVE REANALYSIS; INDIVIDUAL DATA; RISK; WOMEN AB Background: Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk. Study Design: We conducted a systematic review by searching MEDLINE and CENTRAL databases for evidence (in all languages) published in peer-reviewed journals from 1966 to July 2008 that provided estimates of breast cancer risk according to family history. Twelve articles were identified and the quality of each study was assessed using the United States Preventive Services Task Force grading system. Results: Results from 10 studies and one pooled analysis of 54 studies suggest that the use of OCs does not significantly modify the risk of breast cancer among women with a familial history of breast cancer; however, evidence from four studies shows that some women may be at a greater risk, particularly women who took OCs prior to 1975. Conclusions: Current evidence shows that women with a family history of breast cancer do not increase their disease risk by using OCs. (C) 2009 Elsevier Inc. All rights reserved. C1 [Gaffield, Mary E.; Culwell, Kelly R.] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Ravi, Anita] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Gaffield, ME (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM gaffieldm@who.int FU Department of Reproductive Health and Research at the World Health Organization; Centers for Disease Control and Prevention; Association of Schools of Public Health; United States Agency for International Development; National Institute of Child Health and Human Development in the USA FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization, the Centers for Disease Control and Prevention, the Association of Schools of Public Health, the United States Agency for International Development and the National Institute of Child Health and Human Development in the USA. NR 19 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 372 EP 380 DI 10.1016/j.contraception.2009.04.010 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700008 PM 19751860 ER PT J AU Kapp, N Tilley, IB Curtis, KM AF Kapp, Nathalie Tilley, Ian B. Curtis, Kathryn M. TI The effects of hormonal contraceptive use among women with viral hepatitis or cirrhosis of the liver: a systematic review SO CONTRACEPTION LA English DT Review DE Hepatitis; Cirrhosis; Hormonal contraception; Oral contraception; Liver disease ID PRIMARY BILIARY-CIRRHOSIS; CHRONIC ACTIVE HEPATITIS; ORAL-CONTRACEPTIVES; HEMOSTASIS; ESTRADIOL; DISEASE AB Background: This report evaluates the effects of hormonal contraceptive use among women with viral hepatitis or cirrhosis of the liver. Methods: PubMed and Cochrane databases were searched from inception to June 2008 for publications that examined the use of hormonal contraceptives among women with viral hepatitis or cirrhosis of the liver. Results: Six studies met the inclusion criteria. In one study of acute hepatitis, combined oral contraceptive (COC) use did not affect duration of hospitalization or Successful disease resolution. The remainder of the studies examined chronic hepatitis or its sequelae. Women recovered from hepatitis experienced transaminase elevation with COC use which resolved after 4 weeks in one study or increased slightly over 6 months in another study. Hepatitis B virus carriers using COCs had similar transaminase levels as nonusing carriers over 6 months. Studies of chronic hepatitis C infection demonstrated no influence of COC use on progression or severity of liver fibrosis or development of hepatocellular carcinoma. Conclusion: Data from one study suggest that COCs do not affect the course of acute hepatitis. Limited data from studies on chronic hepatitis or its sequelae suggest that COC use does not affect the rate of progression or severity of cirrhotic fibrosis, the risk of hepatocellular carcinoma in women with chronic hepatitis, or the risk of liver dysfunction in hepatitis B virus carriers. (C) 2009 Elsevier Inc. All rights reserved. C1 [Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. [Tilley, Ian B.] Univ So Calif, Keck Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Kapp, N (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland. EM kappn@who.int FU Department of Reproductive Health and Research at the World Health Organization; Centers for Disease Control and Prevention; US Agency for International Development; National Institute of Child Health and Human Development FX This review was supported by resources from the Department of Reproductive Health and Research at the World Health Organization, the Centers for Disease Control and Prevention, the US Agency for International Development, and the National Institute of Child Health and Human Development. NR 20 TC 12 Z9 12 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 381 EP 386 DI 10.1016/j.contraception.2009.04.007 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700009 PM 19751861 ER PT J AU Kapp, N Curtis, KM AF Kapp, Nathalie Curtis, Kathryn M. TI Hormonal contraceptive use among women with liver tumors: a systematic review SO CONTRACEPTION LA English DT Review DE Liver tumor; Liver neoplasm; Hormonal contraception; Systematic review; Focal nodular hyperplasia; Hepatocellular adenoma ID FOCAL NODULAR HYPERPLASIA; HEPATOCELLULAR-CARCINOMA; ORAL-CONTRACEPTIVES; RISK-FACTORS; ADENOMA AB Background: The review was conducted to evaluate from the literature the safety of hormonal methods of contraception in women with liver tumors, specifically in benign and malignant disease. Study Design: We searched PubMed and Cochrane databases to find all articles published from database inception through July 2008 that were relevant to hormonal contraception use and liver tumors. Results: Of 148 articles, three publications of two studies met the criteria for inclusion in this review; both investigated the use of hormonal contraception in women with the benign liver tumor focal nodular hyperplasia (FNH). In one small, retrospective case series, use of combined oral contraceptives (COCs) over a 4-year average follow-up was not associated with a change in either the number or size of hepatic lesions. In another case series, use of either COCs or progestogen-only contraceptives (POCs) after FNH diagnosis had no influence on disease progression or resolution. Conclusions: The studies identified examined oral contraceptive use among women with FNH. We did not identify any studies of hormonal contraceptive use among women with hepatocellular adenoma or with malignant liver tumors. Limited, poor-quality evidence suggests that for women with FNH, use of low-dose COCs or POCs does not appear to influence either liver lesion resolution or progression. (C) 2009 Elsevier Inc. All rights reserved. C1 [Kapp, Nathalie] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Kapp, N (reprint author), WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland. EM kappn@who.int FU World Health Organization; Centers for Disease Control and Prevention; US Agency for International Development; US National Institute of Child Health and Human Development FX This review was supported by resources from the World Health Organization, the Centers for Disease Control and Prevention, the US Agency for International Development and the US National Institute of Child Health and Human Development. NR 20 TC 24 Z9 26 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 387 EP 390 DI 10.1016/j.contraception.2009.01.021 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700010 PM 19751862 ER PT J AU Paulen, ME Curtis, KM AF Paulen, Melissa E. Curtis, Kathryn M. TI When can a woman have repeat progestogen-only injectables-depot medroxyprogesterone acetate or norethisterone enantate? SO CONTRACEPTION LA English DT Review DE Progestogen-only contraception; Depot medroxyprogesterone acetate (DMPA); Norethisterone enantate (NET-EN); Reinjection; Systematic review ID OVARIAN-FUNCTION; STEROID-CONTRACEPTIVES; INUTERO EXPOSURE; THAI WOMEN; RETURN; OVULATION; OENANTHATE; PHARMACOKINETICS; FERTILITY; INJECTION AB Background: Currently, there is a generally accepted 2-week grace period for women returning early/late for reinjection of either depot medroxyprogesterone acetate (DMPA) or norethisterone enantate (NET-EN). This systematic review evaluates the evidence regarding return to fertility and ovulation after injection of a progestogen-only contraceptive. Study Design: We searched the PubMed database to identify all relevant evidence published in peer-reviewed journals from database inception through November 2008 regarding timing of fertility and return to ovulation after the last injection of DMPA or NET-EN. Results: We identified 20 articles, 10 on DMPA use, eight on NET-EN use and two examining both types of injectables. Six studies examining time to pregnancy after discontinuing DMPA or NET-EN reported that pregnancy rates during the currently recommended 2-week grace period were zero or very low. Studies of return to ovulation indicated a wide variation in time to ovulation post-injection with the majority ranging from 15-49 weeks from the last injection (for DMPA) and 4.9-24.3 weeks from the last injection (for NET-EN). Limitations of this body of evidence include small sample sizes, lack of data on the main outcome of interest (time to pregnancy) and inconsistency in measurement of ovulation, a surrogate measurement for pregnancy risk. Conclusion: Studies evaluating time to pregnancy after last injection of DMPA or NET-EN reported extremely low pregnancy rates during the 2-week interval following the reinjection date; extremely low pregnancy rates for DMPA were also reported for 4 weeks following the reinjection date. Studies of return to ovulation after last injection of DMPA generally found that the earliest ovulation did not occur until several months after the last injection while studies of NET-EN reported ovulations around (or even before) the time for reinjection. (C) 2009 Elsevier Inc. All rights reserved. C1 [Paulen, Melissa E.; Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. EM kmc6@cdc.gov FU WHO; US Centers for Disease Control and Prevention; US Agency for International Development; US National Institute of Child Health and Human Development FX This review was supported by resources from the WHO, the US Centers for Disease Control and Prevention, US Agency for International Development and the US National Institute of Child Health and Human Development. NR 31 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-7824 J9 CONTRACEPTION JI Contraception PD OCT PY 2009 VL 80 IS 4 BP 391 EP 408 DI 10.1016/j.contraception.2009.03.023 PG 18 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 500YD UT WOS:000270341700011 PM 19751863 ER PT J AU Bang, KM Syamlal, G Mazurek, JM AF Bang, Ki Moon Syamlal, Girija Mazurek, Jacek M. TI Prevalence of Chronic Obstructive Pulmonary Disease in the US Working Population: An Analysis of Data from the 1997-2004 National Health Interview Survey SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE Chronic obstructive pulmonary disease; Prevalence; Occupation; Industry ID NUTRITION-EXAMINATION-SURVEY; CHRONIC-BRONCHITIS; OCCUPATIONAL EXPOSURES; LUNG-FUNCTION; RESPIRATORY SYMPTOMS; BURDEN; COPD; COMMUNITY; SMOKING; MINERS AB To estimate the prevalence and the population attributable fraction of chronic obstructive pulmonary disease (COPD) in the U.S. adult workers, we analyzed data obtained from the National Health Interview Surveys for the period 1997-2004. The overall COPD prevalence was 4.0% (95% confidence interval [CI] 3.9-4.1%). The prevalence was higher in females (5.4%, 95% CI 5.3-5.6%) than in males (2.8%, 95% CI 2.7-2.9%); in Whites (4.2%, 95% CI 4.1-4.3%) than in Blacks (3.4%, 95% CI 3.1-3.7%) and other races (2.4%, 95% CI 2.1-2.8%). Compared with insurance, real estate and other finance industry, the top three industries associated with significantly higher prevalence odds ratios (PORs) (adjusted for age, sex, race, and smoking) were other educational services (POR = 1.5, 95% CI 1.0-2.3); transportation equipment (POR = 1.4, 95% CI 1.1-1.8); and social services, religious and membership organizations (POR = 1.4, 95% CI 1.1-1.7). Compared with managers and administrators, except public administration occupation, the top three occupations with significantly higher PORs were health service (1.8, 95% CI 1.5-2.1), other protective service (POR = 1.6, 95% CI 1.2-2.2), and material moving equipment operators (POR = 1.6, 95% CI 1.1-2.3). The overall population attributable fraction for association of COPD with employment was 12.2% for industry and 17.4% for occupation. Further studies are needed to determine specific risk factors associated with COPD in industries and occupations with elevated prevalence and POR. C1 [Bang, Ki Moon; Syamlal, Girija; Mazurek, Jacek M.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Bang, KM (reprint author), NIOSH, Div Resp Dis Studies, CDC, RM H-G900-2,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM kmb2@cdc.gov; GSyamal@cdc.gov; ACQ8@cdc.gov NR 52 TC 10 Z9 10 U1 0 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1541-2555 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PD OCT PY 2009 VL 6 IS 5 BP 380 EP 387 DI 10.1080/15412550903140899 PG 8 WC Respiratory System SC Respiratory System GA 604KA UT WOS:000278276700008 PM 19863367 ER PT J AU Marano, C Freedman, DO AF Marano, Cinzia Freedman, David O. TI Global health surveillance and travelers' health SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE chikungunya; dengue; global health surveillance; hepatitis A; ill returned travelers ID ACUTE SCHISTOSOMIASIS; MALAYSIAN BORNEO; DISEASE; GEOSENTINEL; INTERNET; MALARIA; NETWORK AB Purpose of review Monitoring disease trends among travelers can inform both pretravel advice and posttravel management. Data from sentinel travelers upon their return to medically sophisticated environments can also benefit local populations in resource-limited countries. Recent findings Provider-based surveillance of travelers is increasingly sophisticated. Recently, networks such as GeoSentinel have provided cumulative trends in travel-related illness to assess pretravel risk for a mass gathering event - the Beijing Olympic Games. Data provided by the GeoSentinel also helped in determining the seasonality of dengue by region of travel and risk of acquiring schistosomiasis after a single short exposure. For chikungunya fever, detailed study of returned travelers exposed new clinical aspects of a disease previously studied in the tropics only. Clusters of hepatitis A, a vaccine-preventable disease, among European travelers, illustrated continued gaps in the preparation of the traveling public. Plasmodium knowlesi has emerged as the fifth human malaria parasite and is now a consideration in the diagnosis of febrile travelers from Asia. Automated global news scanning software is increasingly being able to detect and prioritize disease events. Summary Every year millions of travelers visit countries where they are exposed to pathogens that are usually rare in their home countries. Global surveillance of travel-related disease represents a powerful tool for the detection of infectious diseases. These data should encourage clinicians to take a detailed travel history during every patient encounter. C1 [Freedman, David O.] Univ Alabama, Div Infect Dis, WC Gorgas Ctr Geog Med, Birmingham, AL 35294 USA. [Marano, Cinzia] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Travelers Hlth & Anim Importat Branch, Atlanta, GA USA. RP Freedman, DO (reprint author), Univ Alabama, Div Infect Dis, WC Gorgas Ctr Geog Med, 1530 3rd Ave S,BBRB 201, Birmingham, AL 35294 USA. EM freedman@uab.edu FU GeoSentinel Surveillance Network FX David Freedman is a founding director of the GeoSentinel Surveillance Network and Cinzia Marano is CDC/GeoSentinel Director. NR 31 TC 12 Z9 13 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD OCT PY 2009 VL 22 IS 5 BP 423 EP 429 DI 10.1097/QCO.0b013e32832ee896 PG 7 WC Infectious Diseases SC Infectious Diseases GA 497IL UT WOS:000270052300001 PM 19726984 ER PT J AU Stauffer, WM Weinberg, M AF Stauffer, William M. Weinberg, Michelle TI Emerging clinical issues in refugees SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE infection; intestinal parasite; malaria; mobile population; refugees ID UNITED-STATES; INTESTINAL PARASITES; MALARIA; TUBERCULOSIS; METAANALYSIS; EOSINOPHILIA; IMMIGRANTS; TRAVELERS; OUTBREAK; IMPACT AB Purpose of review The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease specialists. Recent findings Refugee migration to the United States represents the most controlled population movement between countries from a health perspective. Medical screening and programs that provide presumptive treatment for highly prevalent infectious diseases both prior to and after migration alter the infectious disease epidemiology in these populations. Summary Infectious disease specialists must recognize that different characteristics of distinct mobile populations will alter infectious disease burden. This article specifically highlights how recent public health approaches have altered the epidemiology and clinical presentation of malaria, intestinal parasites and tuberculosis in refugee populations. C1 [Stauffer, William M.] Univ Minnesota, Dept Med & Pediat, Minneapolis, MN 55455 USA. [Stauffer, William M.; Weinberg, Michelle] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Minneapolis, MN USA. RP Stauffer, WM (reprint author), Univ Minnesota, Dept Med, Div Infect Dis & Int Hlth, 420 Delaware St SE,Mayo D-407,MMC 250, Minneapolis, MN 55455 USA. EM stauf005@umn.edu NR 36 TC 12 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0951-7375 EI 1473-6527 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD OCT PY 2009 VL 22 IS 5 BP 436 EP 442 DI 10.1097/QCO.0b013e32832f14a4 PG 7 WC Infectious Diseases SC Infectious Diseases GA 497IL UT WOS:000270052300003 PM 19587590 ER PT J AU Hogben, M Burstein, GR Golden, MR AF Hogben, Matthew Burstein, Gale R. Golden, Matthew R. TI Partner notification in the clinician's office: patient health, public health and interventions SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY LA English DT Article DE partner notification; partner treatment; sexually transmitted disease ID SEXUALLY-TRANSMITTED INFECTIONS; HERPES-SIMPLEX-VIRUS; CHLAMYDIAL INFECTION; SEX PARTNERS; CONTROLLED-TRIAL; UNITED-STATES; NATIONAL-SURVEY; GENITAL HERPES; THERAPY; GONORRHEA AB Purpose of review Partner notification is an essential element of sexually transmitted disease infection control. Patients may be interviewed by public health staff, followed by public health staff notification of those partners (provider referral), or they receive some form of instruction to notify and refer their own partners (patient referral). In this review, we review partner notification and current research and programmatic activity. Recent findings Resource limitations restrain provider referral to a minority of cases. Patient referral is far more widely practiced and is the subject of some recent enhancements. Foremost among these is the growing practice of expedited partner therapy, in which partner treatment may occur through the provision of medications or prescriptions prior to a clinical evaluation. Trials in which patients took medications to their partners have been supported, and the practice is gaining acceptance nationally. Other counseling also increases patient referral efficacy. Finally, the role of the internet in both provider and patient referral has received increasing attention and is being incorporated into program practice. Summary Clinical providers can intervene at the point of care to serve both patients as individuals and infection control more broadly. Cooperation between public health agencies, other organizations and clinical providers can facilitate both goals. C1 [Hogben, Matthew] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Burstein, Gale R.] Womens & Childrens Hosp, Buffalo, NY USA. [Golden, Matthew R.] Publ Hlth Serv King Cty, Seattle, WA USA. RP Hogben, M (reprint author), Ctr Dis Control & Prevent, Mail Stop E-44, Atlanta, GA 30333 USA. EM mhogben@cdc.gov NR 33 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-872X J9 CURR OPIN OBSTET GYN JI Curr. Opin. Obstet. Gynecol. PD OCT PY 2009 VL 21 IS 5 BP 365 EP 370 DI 10.1097/GCO.0b013e3283307c2a PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 497LX UT WOS:000270062100001 PM 19633553 ER PT J AU Goodman, AG Zeng, H Cilloniz, C Carter, VS Peng, XX Proll, SC Tumpey, TM Katze, MG AF Goodman, Alan G. Zeng, Hui Cilloniz, Cristian Carter, Victoria S. Peng, Xinxia Proll, Sean C. Tumpey, Terrence M. Katze, Michael G. TI The Type I interferon receptor protects against influenza virus replication while the Type II receptor is dispensible SO CYTOKINE LA English DT Meeting Abstract CT Tri-Society Annual Conference of the International-Cytokine-Society/International-Society-of-Interferon-and-C ytokine-Research/Society-of-Leukocyte-Biology CY OCT 17-21, 2009 CL Lisbon, PORTUGAL SP Int Cytokine Soc, Int Soc Interferon & Cytokin Res, Soc Leukocyte Biol C1 [Goodman, Alan G.; Cilloniz, Cristian; Carter, Victoria S.; Peng, Xinxia; Proll, Sean C.; Katze, Michael G.] Univ Washington, Seattle, WA 98195 USA. [Zeng, Hui; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1043-4666 J9 CYTOKINE JI Cytokine PD OCT-NOV PY 2009 VL 48 IS 1-2 BP 83 EP 83 DI 10.1016/j.cyto.2009.07.294 PG 1 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA 507LN UT WOS:000270855100287 ER PT J AU Jones, GC AF Jones, Gwyn C. TI Aging with cerebral palsy and other disabilities: personal reflections and recommendations SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY LA English DT Editorial Material AB This article describes the lived experience of one 64-year-old woman who is aging with cerebral palsy (CP) and other multiple disabilities. Reflections are offered on coping with secondary conditions and functional decline; fighting the effects of pain and fatigue; and managing well-meaning, but misdirected, medical advice. Recommendations based on the author's personal and professional experience with disabilities, including CP, are presented on the aging process and on preventive care for adults living with CP. C1 Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Jones, GC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E88, Atlanta, GA 30333 USA. EM gbj4@cdc.gov NR 0 TC 3 Z9 3 U1 3 U2 6 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0012-1622 J9 DEV MED CHILD NEUROL JI Dev. Med. Child Neurol. PD OCT PY 2009 VL 51 BP 12 EP 15 DI 10.1111/j.1469-8749.2009.03427.x PG 4 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 490WS UT WOS:000269539400003 PM 19740205 ER PT J AU Schendel, DE Autry, A Wines, R Moore, C AF Schendel, Diana E. Autry, Andrew Wines, Roberta Moore, Cynthia TI The co-occurrence of autism and birth defects: prevalence and risk in a population-based cohort SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY LA English DT Article ID US METROPOLITAN-AREA; DOWNS-SYNDROME; MEDICAL DISORDERS; SPECTRUM DISORDERS; CHILDREN; ADOLESCENTS; SURVEILLANCE; DISABILITIES; BEHAVIOR AB AIM To estimate the prevalence of major birth defects among children with autism, the prevalence of autism in children with birth defects, and the risk for autism associated with having birth defects. METHOD Retrospective cohort including all children born in Atlanta, GA, USA, 1986 to 1993, who survived to age 3 years and were identified through Georgia vital records. Children with autism and other developmental disabilities residing in Atlanta at ages 3 to 10 years in 1996 were identified through the Metropolitan Atlanta Developmental Disabilities Surveillance Program. Children with major birth defects through age 6 years were identified by the Metropolitan Atlanta Congenital Defects Program. RESULTS Birth defects were found among 6% of children with autism (total n=617; 488 males, 129 females) and was associated with a near twofold increased risk for autism overall. However, the risk magnitude and statistical significance varied by type of birth defect. With any type of birth defect, the risk for autism accompanied by intellectual disability or other developmental disabilities was typically higher than the risk for autism alone. A 6: 1 to 8: 1 male bias was observed among children with autism and a birth defect. INTERPRETATION Investigation of the association between autism and birth defects is warranted, especially for the role of birth defects in autism among sex-specific or autism subgroups. C1 [Schendel, Diana E.; Autry, Andrew; Wines, Roberta; Moore, Cynthia] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Schendel, DE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM dschendel@cdc.gov NR 30 TC 18 Z9 18 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0012-1622 J9 DEV MED CHILD NEUROL JI Dev. Med. Child Neurol. PD OCT PY 2009 VL 51 IS 10 BP 779 EP 786 DI 10.1111/j.1469-8749.2009.03310.x PG 8 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 491PE UT WOS:000269590500006 PM 19416313 ER PT J AU Greenbaum, CJ Anderson, AM Dolan, LM Mayer-Davis, EJ Dabelea, D Imperatore, G Marcovina, S Pihoker, C AF Greenbaum, Carla J. Anderson, Andrea M. Dolan, Lawrence M. Mayer-Davis, Elizabeth J. Dabelea, Dana Imperatore, Giuseppina Marcovina, Santica Pihoker, Catherine CA SEARCH Study Grp TI Preservation of beta-Cell Function in Autoantibody-Positive Youth With Diabetes SO DIABETES CARE LA English DT Article ID RESIDUAL INSULIN-SECRETION; 1ST YEAR; ORAL INSULIN; FOLLOW-UP; MELLITUS; TYPE-1; DIAGNOSIS; MULTICENTER; ANTIBODIES; CHILDREN AB OBJECTIVE - To determine the extent of beta-cell function in youth with diabetes and GAD65 and/or IA2 autoantibodies. RESEARCH DESIGN AND METHODS - Fasting C-peptide levels from 2,789 GAD65- and/or IA2 autoantibody-positive youth aged 1-23 years from the SEARCH for Diabetes in Youth study were used. Preserved beta-cell function was defined on the basis of cut points derived from the Diabetes Control and Complications Trial (DCCT) (fasting C-peptide >= 0.23 ng/ml) and from the U.S. adolescent population of the National Health and Nutrition Examination Survey (NHANES) 5th percentile for fasting C-peptide (>= 1.0 ng/ml). We compared the clinical characteristics between those with and without preserved beta-cell function. RESULTS - Within the first year of diagnosis, 82.9% of youth had a fasting C-peptide >= 0.23 ng/ml and 31.1% had values >= 1.0 ng/ml. Among those with 5 years of diabetes duration, 10.7% had preserved beta-cell function based on the DCCT cutoff and 1.0% were above the 5th percentile of the NHANES population. CONCLUSIONS - Within the 1st year of diagnosis, four of five youth with autoantibody-positive diabetes have clinically significant amounts of residual beta-cell function and about one-third have fasting C-peptide levels above the 5th percentile of a healthy adolescent population. Even 5 years after diagnosis, 1 of 1.0 has fasting C-peptide above a clinically significant threshold. These findings have implications for clinical classification of youth with diabetes as well as clinical trials aimed to preserve beta-cell function after diabetes onset. C1 [Greenbaum, Carla J.] Benaroya Res Inst, Diabet Res Program, Seattle, WA USA. [Anderson, Andrea M.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA. [Dolan, Lawrence M.] Cincinnati Childrens Hosp & Med Ctr, Cincinnati, OH USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA. [Mayer-Davis, Elizabeth J.] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. [Dabelea, Dana] Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA USA. [Marcovina, Santica] Univ Washington, Dept Med, Seattle, WA USA. [Pihoker, Catherine] Univ Washington, Dept Pediat, Seattle, WA USA. RP Greenbaum, CJ (reprint author), Benaroya Res Inst, Diabet Res Program, Seattle, WA USA. EM cjgreen@benaroyaresearch.org FU General Clinical Research Centers [M01 RR01070, M01 RR08084, M01RR00037, M01RR001271, M01 RR00069] FX We acknowledge the involvement of General Clinical Research Centers at the following institutions: Medical Center of South Carolina (Grant M01 RR01070), Cincinnati Children's Hospital (Grant M01 RR08084), Children's Hospital and Regional Medical Center and the University of Washington School of Medicine (Grant M01RR00037 and Grant M01RR001271), and Colorado Pediatric General Clinical Research Center (Grant M01 RR00069). NR 24 TC 35 Z9 37 U1 0 U2 3 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD OCT PY 2009 VL 32 IS 10 BP 1839 EP 1844 DI 10.2337/dc08-2326 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 509HE UT WOS:000271004900014 PM 19587365 ER PT J AU Pavkov, ME Curtis, JM Mason, CC Knowler, WC Bennett, PH Nelson, RG AF Pavkov, Meda E. Curtis, Jeffrey M. Mason, Clinton C. Knowler, William C. Bennett, Peter H. Nelson, Robert G. TI Change in the Distribution of Albuminuria According to Estimated Glomerular Filtration Rate in Pima Indians With Type 2 Diabetes SO DIABETES CARE LA English DT Article ID RENAL-DISEASE; MELLITUS; NEPHROPATHY; INSUFFICIENCY; PROTEINURIA; PROGRESSION; POPULATION; PRESSURE; EQUATION; DIET AB OBJECTIVE - We examined secular trends in the frequency distribution of albuminuria and estimated glomerular filtration rate (eGFR) in subjects with type 2 diabetes in 1982-1988 and 2001-2006, two periods associated with major changes in the management of diabetes. RESEARCH DESIGN AND METHODS - The cross-sectional study included Pima Indians >= 15 years old with type 2 diabetes and measures of serum creatinine and urinary albumin-to-creatinine ratios (ACR). The continuous probability density distributions of ACR and eGFR were compared for the two time periods. eGFR was calculated using the Modification of Diet in Renal Disease Study equation. RESULTS - The overall standardized distribution of ACR shifted toward lower values between time periods (P = 0.001), whereas the standardized distribution of eGFR did not (P = 0.45). In the first period, eGFR was <60 ml/min per 1.73 m(2) in 6.5% of the 837 subjects. Of these, 9.3% had normal ACR, 7.4% had microalbuminuria, and 83.3% had macroalbuminuria. in the second period, the prevalence of low eGFR was similar (6.6% of the 1,310 subjects). Among those with low eGFR, normal ACR prevalence doubled to 17.2%, microalbuminuria prevalence nearly tripled to 19.5%, and macroalbuminuria prevalence declined to 63.2%. Twice as man), subjects in the second period received antihypertensive medicines and 30% more received hypoglycemic medicines than in the first period. CONCLUSIONS - The distribution of albuminuria changed significantly among diabetic Pima Indians over the past 20 years, as treatment with medicines to control hyperglycemia and hypertension increased. The distribution of eGFR, however, remained unchanged. Consequently, the frequency of chronic kidney disease characterized by normoalbuminuria and low eGFR doubled. C1 [Pavkov, Meda E.; Curtis, Jeffrey M.; Mason, Clinton C.; Knowler, William C.; Bennett, Peter H.; Nelson, Robert G.] NIDDKD, Diabet Epidemiol & Clin Res Sect, NIH, Phoenix, AZ USA. [Pavkov, Meda E.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA USA. RP Pavkov, ME (reprint author), NIDDKD, Diabet Epidemiol & Clin Res Sect, NIH, Phoenix, AZ USA. EM mpavkov@cdc.gov RI Nelson, Robert/B-1470-2012 FU National Institute of Diabetes and Digestive and Kidney Diseases; American Diabetes Association FX This research was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. M.E.P. was supported by a Mentor-Based Fellowship award from the American Diabetes Association. NR 24 TC 8 Z9 8 U1 0 U2 1 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD OCT PY 2009 VL 32 IS 10 BP 1845 EP 1850 DI 10.2337/dc08-2325 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 509HE UT WOS:000271004900015 PM 19592626 ER PT J AU Campos, LC Carvalho, MDS Beall, BW Cordeiro, SM Takahashi, D Reis, MG Ko, AI Reis, JN AF Campos, Leila C. Carvalho, Maria da Gloria S. Beall, Bernard W. Cordeiro, Soraia M. Takahashi, Daniele Reis, Mitermayer G. Ko, Albert I. Reis, Joice N. TI Prevalence of Streptococcus pneumoniae serotype 6C among invasive and carriage isolates in metropolitan Salvador, Brazil, from 1996 to 2007 SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Streptococcus pneumoniae; Serotype 6C; Epidemiology; Meningitis; Carriage ID FIELD GEL-ELECTROPHORESIS; UNITED-STATES; PNEUMOCOCCAL SEROTYPE; DISEASE AB The newly described Streptococcus pnemnoniae serotype 6C accounted for 2.3% (16/709) of meningitis cases and 3.2% (3/95) of nasopharyngeal isolates from healthy individuals in Brazil. The strains were multidrug resistant (18.8%) and genetically diverse. Despite low serotype 6C prevalence, Continuous surveillance is necessary to guide vaccine strategies. (C) 2009 Elsevier Inc. All rights reserved. C1 [Campos, Leila C.; Cordeiro, Soraia M.; Takahashi, Daniele; Reis, Mitermayer G.; Ko, Albert I.; Reis, Joice N.] Fundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil. [Campos, Leila C.] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil. [Carvalho, Maria da Gloria S.; Beall, Bernard W.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. [Ko, Albert I.] Cornell Univ, Weill Med Coll, Dept Med, Div Infect Dis, New York, NY 10021 USA. [Reis, Joice N.] Univ Fed Bahia, Fac Farm, BR-40170115 Salvador, BA, Brazil. RP Reis, JN (reprint author), Fundacao Oswaldo Cruz MS, Ctr Pesquisas Goncalo Moniz, Rua Waldemar Falcao 121, BR-40296710 Salvador, BA, Brazil. EM joice@ufba.br RI Vacinas, Inct/J-9431-2013; Ko, Albert/P-2343-2015; Reis, Joice/H-9227-2013 FU FIC NIH HHS [D43 TW000919, D43 TW000919-09, D43 TW000919-10, D43TW00919, R01 TW007303, R01 TW007303-01, R01 TW007303-02, R01 TW007303-03, R01 TW007303-04, R01 TW007303-05]; Wellcome Trust NR 21 TC 22 Z9 22 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD OCT PY 2009 VL 65 IS 2 BP 112 EP 115 DI 10.1016/j.diagmicrobio.2009.06.020 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 499XP UT WOS:000270260400006 PM 19709842 ER PT J AU Cairns, KL Woodruff, BA Myatt, M Bartlett, L Goldberg, H Roberts, L AF Cairns, K. Lisa Woodruff, Bradley A. Myatt, Mark Bartlett, Linda Goldberg, Howard Roberts, Les TI Cross-sectional survey methods to assess retrospectively mortality in humanitarian emergencies SO DISASTERS LA English DT Article DE cross-sectional surveys; humanitarian emergencies; mortality ID MATERNAL MORTALITY; VERBAL AUTOPSIES; WEST DARFUR; DEATH; VALIDATION; MISCLASSIFICATION; FRACTIONS; REFUGEES; CHILDREN; VALIDITY AB Since the rates and causes of mortality are critical indicators of the overall health of a population, it is important to evaluate mortality even where no complete vital statistics reporting exists. Such settings include humanitarian emergencies. Experience in cross-sectional survey methods to assess retrospectively crude, age-specific, and maternal mortality in stable settings has been gained over the past 40 years, and methods appropriate to humanitarian emergencies have been developed. In humanitarian emergencies, crude and age-specific mortality can be gauged using methods based on the enumeration of individuals resident in randomly selected households-frequently referred to as a household census. Under-five mortality can also be assessed through a modified prior birth history method in which a representative sample of reproductive-aged women are questioned about dates of child births and deaths. Maternal mortality can be appraised via the initial identification of maternal deaths in the study population and a subsequent investigation to determine the cause of each death. C1 [Cairns, K. Lisa] Ctr Dis Control & Prevent, Global Immunizat Div, Natl Immunizat Program, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA. [Woodruff, Bradley A.] Int Hlth & Nutr, Beijing, Peoples R China. [Bartlett, Linda] Johns Hopkins Univ, Dept Int Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Goldberg, Howard] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. [Roberts, Les] Columbia Univ, Program Forced Migrat & Hlth, Mailman Sch Publ Hlth, New York, NY USA. RP Cairns, KL (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, Natl Immunizat Program, Coordinating Ctr Infect Dis, 1600 Clifton Rd,Mail Stop E-05, Atlanta, GA 30333 USA. EM kfc4@cdc.gov NR 61 TC 3 Z9 3 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0361-3666 EI 1467-7717 J9 DISASTERS JI Disasters PD OCT PY 2009 VL 33 IS 4 BP 503 EP 521 DI 10.1111/j.0361-3666.2008.01085.x PG 19 WC Planning & Development SC Public Administration GA 476MN UT WOS:000268446800001 PM 19500327 ER PT J AU Sanchez, C Lee, TS Young, S Batts, D Benjamin, J Malilay, J AF Sanchez, Carlos Lee, Tze-San Young, Stacy Batts, Dahna Benjamin, Jefferson Malilay, Josephine TI Risk factors for mortality during the 2002 landslides in Chuuk, Federated States of Micronesia SO DISASTERS LA English DT Article DE conditional logistic regression; landslide; mortality; odds ratio; proxy AB This study examines health effects resulting from landslides in Chuuk during Tropical Storm Chata'an in July 2002, and suggests strategies to prevent future mortality. In August 2002, we conducted a cross-sectional survey to identify risk factors for mortality during landslides, which included 52 survivors and 40 surrogates for 43 decedents to identify risk factors for death. Findings suggest that 1) females had a higher mortality rate from this event than males, and 2) children aged 5-14 years had a 10-fold increase in mortality when compared with annual mortality rates from all causes. Awareness of landslides occurring elsewhere and knowledge of natural warning signs were significantly associated with lower risks of death; being outside during landslides was not associated with reduced mortality. In Chuuk, improving communication systems during tropical storms and increasing knowledge of natural warnings can reduce the risk for mortality during landslides. C1 [Sanchez, Carlos] Ctr Dis Control & Prevent CDC, NCEH, Epidem Intelligence Serv, Atlanta, GA USA. [Lee, Tze-San] CDC, Div Environm Hazards & Hlth Effects EHHE, NCEH, Atlanta, GA 30341 USA. [Young, Stacy; Batts, Dahna] CDC, Hlth Studies Branch, EHHE, NCEH, Atlanta, GA 30341 USA. [Malilay, Josephine] CDC, Disaster Epidemiol & Assessment Team, Hlth Studies Branch, EHHE,NCEH, Atlanta, GA 30341 USA. RP Lee, TS (reprint author), CDC, Div Environm Hazards & Hlth Effects EHHE, NCEH, Mail Stop F-58, Atlanta, GA 30341 USA. EM tjl3@cdc.gov NR 41 TC 6 Z9 6 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0361-3666 J9 DISASTERS JI Disasters PD OCT PY 2009 VL 33 IS 4 BP 705 EP 720 DI 10.1111/j.0361-3666.2009.01105.x PG 16 WC Planning & Development SC Public Administration GA V22KW UT WOS:000208275100003 PM 19459918 ER PT J AU Winthrop, KL Chang, E Yamashita, S Lademarco, MF LoBue, PA AF Winthrop, Kevin L. Chang, Eric Yamashita, Shellie Lademarco, Michael F. LoBue, Philip A. TI Nontuberculous Mycobacteria Infections and Anti-Tumor Necrosis Factor-alpha Therapy SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RHEUMATOID-ARTHRITIS; GRANULOMATOUS INFECTIONS; TUBERCULOSIS INFECTION; RECOMMENDATIONS; ETANERCEPT; PATIENT; DISEASE; PREVENTION; INFLIXIMAB; STATEMENT AB Patients receiving anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. We reviewed the US Food and Drug Administration MedWatch database for reports of NTM disease in patients receiving anti-TNF-alpha therapy. Of 239 reports collected, 105 (44%) met NTM disease criteria. Median age was 62 years; the majority of patients (66, 65%) were female, and most (73, 70%) had rheumatoid arthritis. NTM infections were associated with infliximab (n = 73), etanercept (n = 25), and adalimumab (n = 7); most patients were taking prednisone (n = 68, 65%) or methotrexate (n = 58, 55%) concurrently. Mycobacteria avium (n = 52, 50%) was most commonly implicated, and 9 patients (9%) had died at the time their infections were reported. A high rate of extrapulmonary manifestations (n = 46, 44%) was also reported. C1 [Winthrop, Kevin L.] Oregon Hlth & Sci Univ, Casey Eye Inst, Dept Infect Dis, Portland, OR 97239 USA. [Lademarco, Michael F.] US PHS, Washington, DC USA. [LoBue, Philip A.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Winthrop, KL (reprint author), Oregon Hlth & Sci Univ, Casey Eye Inst, Dept Infect Dis, 3375 SW Terwilliger Blvd, Portland, OR 97239 USA. EM winthrop@ohsu.edu FU Agency for Healthcare Research and Quality [1K08HS017552-01]; UCB Pharmaceuticals (Brussels, Belgium) FX K.L.W. was supported by grant 1K08HS017552-01 from the Agency for Healthcare Research and Quality and a grant from UCB Pharmaceuticals (Brussels, Belgium) and received scientific advisory board fees from Amgen (Thousand Oaks, CA, USA) and Genentech (South San Francisco, CA, USA). NR 23 TC 112 Z9 112 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1556 EP 1561 DI 10.3201/eid1510.090310 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600002 PM 19861045 ER PT J AU Paweska, JT Sewlall, NH Ksiazek, TG Blumberg, LH Hale, MJ Lipkin, WI Weyer, J Nichol, ST Rollin, PE McMullan, LK Paddock, CD Briese, T Mnyaluza, J Dinh, TH Mukonka, V Ching, P Duse, A Richards, G de Jong, G Cohen, C Ikalafeng, B Mugero, C Asomugha, C Malotle, MM Nteo, DM Misiani, E Swanepoel, R Zaki, SR AF Paweska, Janusz T. Sewlall, Nivesh H. Ksiazek, Thomas G. Blumberg, Lucille H. Hale, Martin J. Lipkin, W. Ian Weyer, Jacqueline Nichol, Stuart T. Rollin, Pierre E. McMullan, Laura K. Paddock, Christopher D. Briese, Thomas Mnyaluza, Joy Dinh, Thu-Ha Mukonka, Victor Ching, Pamela Duse, Adriano Richards, Guy de Jong, Gillian Cohen, Cheryl Ikalafeng, Bridget Mugero, Charles Asomugha, Chika Malotle, Mirriam M. Nteo, Dorothy M. Misiani, Eunice Swanepoel, Robert Zaki, Sherif R. CA Outbreak Control Team Invest Team TI Nosocomial Outbreak of Novel Arenavirus Infection, Southern Africa SO EMERGING INFECTIOUS DISEASES LA English DT Article ID LASSA VIRUS; DISEASES; STRAIN; FEVER AB A nosocomial outbreak of disease involving 5 patients, 4 of whom died, occurred in South Africa during September-October 2008. The first patient had been transferred from Zambia to South Africa for medical management. Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined. C1 [Paweska, Janusz T.; Blumberg, Lucille H.; Weyer, Jacqueline; de Jong, Gillian; Cohen, Cheryl; Swanepoel, Robert] Natl Inst Communicable Dis, ZA-2131 Johannesburg, South Africa. [Sewlall, Nivesh H.; Hale, Martin J.; Duse, Adriano] Univ Witwatersrand, Johannesburg, South Africa. [Ksiazek, Thomas G.; Nichol, Stuart T.; Rollin, Pierre E.; McMullan, Laura K.; Paddock, Christopher D.; Dinh, Thu-Ha; Zaki, Sherif R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lipkin, W. Ian; Briese, Thomas] Columbia Univ, New York, NY USA. [Mnyaluza, Joy; Ikalafeng, Bridget; Asomugha, Chika] Gauteng Dept Hlth, Johannesburg, South Africa. [Dinh, Thu-Ha] CDC Global AIDS Program, Pretoria, South Africa. [Mukonka, Victor] Minist Hlth, Lusaka, Zambia. [Ching, Pamela] CDC Global AIDS Program, Lusaka, Zambia. [Richards, Guy] Charlotte Maxeke Hosp, Johannesburg, South Africa. [Mugero, Charles; Misiani, Eunice] Natl Dept Hlth, Pretoria, South Africa. [Malotle, Mirriam M.; Nteo, Dorothy M.] Field Epidemiol & Lab Training Programme, Johannesburg, South Africa. [Ksiazek, Thomas G.] Univ Texas Med Branch, Galveston, TX USA. RP Swanepoel, R (reprint author), Natl Inst Communicable Dis, Private Bag X4, ZA-2131 Johannesburg, South Africa. EM bobs@nicd.ac.za NR 11 TC 60 Z9 60 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1598 EP 1602 DI 10.3201/eid1510.090211 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600008 PM 19861052 ER PT J AU Colman, RE Vogler, AJ Lowell, JL Gage, KL Morway, C Reynolds, PJ Ettestad, P Keim, P Kosoy, MY Wagner, DM AF Colman, Rebecca E. Vogler, Amy J. Lowell, Jennifer L. Gage, Kenneth L. Morway, Christina Reynolds, Pamela J. Ettestad, Paul Keim, Paul Kosoy, Michael Y. Wagner, David M. TI Fine-scale Identification of the Most Likely Source of a Human Plague Infection SO EMERGING INFECTIOUS DISEASES LA English DT Article ID YERSINIA-PESTIS; MUTATIONS; NUMBER; DNA AB We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation. C1 [Colman, Rebecca E.; Vogler, Amy J.; Keim, Paul; Wagner, David M.] No Arizona Univ, Flagstaff, AZ 86011 USA. [Lowell, Jennifer L.; Gage, Kenneth L.; Morway, Christina; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Reynolds, Pamela J.; Ettestad, Paul] New Mexico Dept Hlth, Santa Fe, NM USA. RP Wagner, DM (reprint author), No Arizona Univ, Flagstaff, AZ 86011 USA. EM dave.wagner@nau.edu RI Wagner, David/A-5125-2010; Keim, Paul/A-2269-2010 FU National Institutes of Health-National Institute of Allergy and Infectious Diseases [1R15AI070183]; Pacific-Southwest Regional Center of Excellence [AI065359]; Department of Homeland Security Science and Technology Directorate [HSHQDC-08-C-00 158]; Achievement Rewards for College Scientists Foundation Inc.; Cowden Endowment at Northern Arizona University FX This work was supported by the National Institutes of Health-National Institute of Allergy and Infectious Diseases (grant 1R15AI070183), the Pacific-Southwest Regional Center of Excellence (AI065359), the Department of Homeland Security Science and Technology Directorate (contract no. HSHQDC-08-C-00 158), Achievement Rewards for College Scientists Foundation Inc., and the Cowden Endowment at Northern Arizona University. NR 12 TC 14 Z9 14 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1623 EP 1625 DI 10.3201/eid1510.090188 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600013 PM 19861057 ER PT J AU Schultz, MG AF Schultz, Myron G. TI Who Is This Man? Henry Rose Carter SO EMERGING INFECTIOUS DISEASES LA English DT Biographical-Item C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Schultz, MG (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D69, Atlanta, GA 30333 USA. EM mgs1@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1681 EP 1684 DI 10.3201/eid1510.090129 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600031 PM 19877378 ER PT J AU Potter, P AF Potter, Polyxeni TI Alone Together Then and Now SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM PMP1@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2009 VL 15 IS 10 BP 1708 EP 1709 DI 10.3201/eid1510.000000 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 503ZD UT WOS:000270580600047 ER PT J AU Calafat, AM Needham, LL AF Calafat, Antonia M. Needham, Larry L. TI What Additional Factors Beyond State-of-the-Art Analytical Methods Are Needed for Optimal Generation and Interpretation of Biomonitoring Data? SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Editorial Material DE BPA; contamination; DEHP; extraction efficiency; field blank; phthalates ID HUMAN EXPOSURE ASSESSMENT; ENDOCRINE-DISRUPTING CHEMICALS; DEUTERIUM-LABELED DEHP; DI(2-ETHYLHEXYL)PHTHALATE DEHP; HUMAN URINE; DI-(2-ETHYLHEXYL) PHTHALATE; INTERNAL EXPOSURE; METABOLITES; POPULATION; BIOMARKERS AB BACKGROUND: The routine use of biomonitoring (i.e., measurement of environmental chemicals, their metabolites, or specific reaction products in human biological specimens) to assess internal exposure (i.e., body burden) has gained importance in exposure assessment. OBJECTIVES: Selection and validation of biomarkers of exposure are critical factors in interpreting biomonitoring data. Moreover, the strong relation between quality of the analytical methods used for biomonitoring and quality of the resulting data is well understood. However, the relevance of collecting, storing, processing, and transporting the samples to the laboratory to the overall biomonitoring process has received limited attention, especially for organic chemicals. DISCUSSION: We present examples to illustrate potential sources of unintended contamination of the biological specimen during collection or processing procedures. The examples also highlight the importance of ensuring that the biological specimen analyzed both represents the sample collected for biomonitoring purposes and reflects the exposure of interest. CONCLUSIONS: Besides using high-quality analytical methods and good laboratory practices for biomonitoring, evaluation of the collection and handling of biological samples should be emphasized, because these procedures can affect the samples integrity and representativeness. Biomonitoring programs would be strengthened with the inclusion of field blanks. C1 [Calafat, Antonia M.; Needham, Larry L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Calafat, AM (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy NE,Mailstop F53, Atlanta, GA 30341 USA. EM Acalafat@cdc.gov RI Needham, Larry/E-4930-2011 NR 44 TC 38 Z9 38 U1 1 U2 8 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2009 VL 117 IS 10 BP 1481 EP 1485 DI 10.1289/ehp.0901108 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 503JI UT WOS:000270529800020 PM 20019895 ER PT J AU Purdue, MP Engel, LS Langseth, H Needham, LL Andersen, A Barr, DB Blair, A Rothman, N McGlynn, KA AF Purdue, Mark P. Engel, Lawrence S. Langseth, Hilde Needham, Larry L. Andersen, Aage Barr, Dana B. Blair, Aaron Rothman, Nathaniel McGlynn, Katherine A. TI Prediagnostic Serum Concentrations of Organochlorine Compounds and Risk of Testicular Germ Cell Tumors SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE chlordanes; organochlorine compounds; polychlorinated biphenyls; p,p '-dichlorodiphenyldichloroethylene; testicular germ cell tumors ID POLYCHLORINATED BIPHENYL CONGENERS; ANDROGEN RECEPTOR ACTIVITIES; PERSISTENT PESTICIDES; SWISS MICE; IN-VITRO; ESTROGEN; ACTIVATION; CHLORDANE; CANCER; BLOOD AB BACKGROUND: Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs). OBJECTIVE: To further investigate this question, we conducted a nested case-control study of TGCTs within the Norwegian Janus Serum Bank cohort. METHODS: The study was conducted among individuals with serum collected between 1972 and 1978. TGCT cases diagnosed through 1999 (n = 49; 27-62 years of age at diagnosis) were identified through linkage to the Norwegian Cancer Registry. Controls (n = 5 1) were matched to cases on region, blood draw year, and age at blood draw. Measurements of 11 OC insecticide compounds and 34 polychlorinated biphenyl (PCB) congeners were performed using gas chromatography/high-resolution mass spectrometry. Case-control comparisons of lipid-adjusted analyte concentrations were performed using the Wilcoxon signed-rank test. Odds ratios (ORs) and 95% confidence intervals (CIs) for tertiles of analyte concentration were calculated using conditional logistic regression. RESULTS: TGCT cases had elevated concentrations of p,p'-DDE (tertile 3 vs. tertile 1. OR (ORT3) 2.2; 95% CI, 0.7-6.5; p(Wilcoxon) = 0.07), oxychlordane (ORT3 3.2; 95% CI, 0.6-16.8; p(Wilcoxon) = 0.05), trans-nonachlor (ORT3 2.6; 95% CI, 0.7-8.9; p(Wilcoxon) = 0.07), and total chlordanes (ORT3 2.0; 95% CI, 0.6-7.2; p(Wilcoxon) = 0.048) compared with controls, although no ORs were statistically significant. Seminoma cases had significantly lower concentrations of PCB congeners 44, 49, and 52 and significantly higher concentrations of PCBs 99, 138, 153, 167, 183, and 195. CONCLUSIONS: Our study provides additional but qualified evidence supporting an association between exposures to p,p'-DDE and chlordane compounds, and possibly some PCB congeners, and TGCT risk. C1 [Purdue, Mark P.; Blair, Aaron; Rothman, Nathaniel; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Rockville, MD 20852 USA. [Engel, Lawrence S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Langseth, Hilde; Andersen, Aage] Norwegian Canc Registry, Oslo, Norway. [Needham, Larry L.; Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Purdue, MP (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, DHHS, EPS Room 8009,6120 Execut Blvd, Rockville, MD 20852 USA. EM purduem@mail.nih.gov RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; Purdue, Mark/C-9228-2016; OI Purdue, Mark/0000-0003-1177-3108; Engel, Lawrence/0000-0001-9268-4830 FU Intramural NIH HHS NR 40 TC 32 Z9 32 U1 0 U2 3 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2009 VL 117 IS 10 BP 1514 EP 1519 DI 10.1289/ehp.0800359 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 503JI UT WOS:000270529800024 PM 20019899 ER PT J AU Cao, Y Chen, AM Radcliffe, J Dietrich, KN Jones, RL Caldwell, K Rogan, WJ AF Cao, Yang Chen, Aimin Radcliffe, Jerilynn Dietrich, Kim N. Jones, Robert L. Caldwell, Kathleen Rogan, Walter J. TI Postnatal Cadmium Exposure, Neurodevelopment, and Blood Pressure in Children at 2, 5, and 7 Years of Age SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE behavior; blood pressure; cadmium; children; clinical trial; intelligence; neurodevelopment ID CHELATION-THERAPY; URINARY CADMIUM; LEAD; HAIR; HYPERTENSION; POPULATION; MAIN; POLLUTANTS; BEHAVIOR; ALCOHOL AB BACKGROUND: Adverse health effects of cadmium in adults are well documented, but little is known about the neuropsychological effects of cadmium in children, and no studies of cadmium and blood pressure in children have been conducted. OBJECTIVE: We examined the potential effects of low-level cadmium exposure on intelligence quotient, neuropsychological functions, behavior, and blood pressure among children, using blood cadmium as a measure of exposure. METHODS: We used the data from a multicenter randomized clinical trial of lead-exposed children and analyzed blood cadmium concentrations using the whole blood samples collected when children were 2 years of age. We compared neuropsychological and behavioral scores at 2, 5, and 7 years of age by cadmium level and analyzed the relationship between blood cadmium levels at 2 years of age and systolic and diastolic blood pressure at 2, 5, and 7 years of age. RESULTS: The average cadmium concentration of these children was 0.21 mu g/L, lower than for adults in the National Health and Nutrition Examination Survey (NHANES), but comparable to concentrations in children < 3 years of age in NHANES. Except for the California Verbal Learning Test for Children, there were no differences in test scores among children in different cadmium categories. For children with detectable pretreatment blood cadmium, after adjusting for a variety of covariates, general linear model analyses showed that at none of the three age points was the coefficient of cadmium on Mental Development Index or IQ statistically significant. Spline regression analysis suggested that behavioral problem scores at 5 and 7 years of age tended to increase with increasing blood cadmium, but the trend was not significant. We found no significant associations between blood cadmium levels and blood pressure. CONCLUSION: We found no significant associations between background blood cadmium levels at 2 years of age and neurodevelopmental end points and blood pressure at 2, 5, and 7 years of age. The neuropsychological or hypertensive effects from longer background exposures to cadmium need further study. C1 [Cao, Yang] Second Mil Med Univ, Fac Hlth Serv, Dept Hlth Stat, Shanghai 200433, Peoples R China. [Cao, Yang; Rogan, Walter J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA. [Chen, Aimin] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE USA. [Radcliffe, Jerilynn] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Radcliffe, Jerilynn] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Dietrich, Kim N.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Epidemiol & Biostat, Cincinnati, OH 45267 USA. [Jones, Robert L.; Caldwell, Kathleen] Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, Atlanta, GA USA. RP Cao, Y (reprint author), Second Mil Med Univ, Fac Hlth Serv, Dept Hlth Stat, Shanghai 200433, Peoples R China. EM caoy2@niehs.nih.gov RI Rogan, Walter/I-6034-2012 OI Rogan, Walter/0000-0002-9302-0160 FU National Institute of Health; National Institute of Environmental Health Sciences FX This research was supported by the Intramural Research Program of the National Institute of Health, National Institute of Environmental Health Sciences. NR 66 TC 33 Z9 36 U1 2 U2 8 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2009 VL 117 IS 10 BP 1580 EP 1586 DI 10.1289/ehp.0900765 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 503JI UT WOS:000270529800034 PM 20019909 ER PT J AU Meeker, JD Hu, H Cantonwine, DE Lamadrid-Figueroa, H Calafat, AM Ettinger, AS Hernandez-Avila, M Loch-Caruso, R Tellez-Rojo, MM AF Meeker, John D. Hu, Howard Cantonwine, David E. Lamadrid-Figueroa, Hector Calafat, Antonia M. Ettinger, Adrienne S. Hernandez-Avila, Mauricio Loch-Caruso, Rita Maria Tellez-Rojo, Martha TI Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE case-control; environment; epidemiology; exposure; pregnancy; prematurity ID 24-HOUR CREATININE CLEARANCE; ENVIRONMENTAL TOBACCO-SMOKE; SERTOLI-CELL INJURY; N-BUTYL PHTHALATE; IN-UTERO EXPOSURE; MONO-(2-ETHYLHEXYL) PHTHALATE; PEROXISOME PROLIFERATORS; PRENATAL EXPOSURE; OXIDATIVE STRESS; GESTATIONAL-AGE AB BACKGROUND: Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. OBJECTIVE: We investigated the relationship between phthalate exposure and preterm birth. METHODS: Within a large Mexican birth cohort study, we compared third-trimester urinary phthalate metabolite concentrations in 30 women who delivered preterm (< 37 weeks of gestation) with those of 30 controls (>= 37 weeks of gestation). RESULTS: Concentrations of most of the metabolites were similar to those reported among U.S. females, although in the present study mono-n-butyl phthalate (MBP) concentrations were higher and monobenzyl phthalate (MBzP) concentrations lower. In a crude comparison before correcting for urinary dilution, geometric mean urinary concentrations were higher for the phthalate metabolites MBP, MBzP, mono(3-carboxylpropyl)phthalate, and four metabolites of di(2-ethylhexyl) phthalate among women who subsequently delivered preterm. These differences remained, but were somewhat lessened, after correction by specific gravity or creatinine. In multivariate logistic regression analysis adjusted for potential confounders, elevated odds of having phthalate metabolite concentrations above the median level were found. CONCLUSIONS: We found that phthalate exposure is prevalent among this group of pregnant women in Mexico and that some phthalates may be associated with preterm birth. C1 [Meeker, John D.; Hu, Howard; Cantonwine, David E.; Ettinger, Adrienne S.; Loch-Caruso, Rita] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Lamadrid-Figueroa, Hector; Maria Tellez-Rojo, Martha] Natl Inst Publ Hlth, Ctr Evaluat Res & Surveys, Div Stat, Cuernavaca, Morelos, Mexico. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ettinger, Adrienne S.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Hernandez-Avila, Mauricio] Minist Hlth, Mexico City, DF, Mexico. RP Meeker, JD (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 6635 SPH Tower,109 S Observ St, Ann Arbor, MI 48109 USA. EM meekerj@umich.edu OI Loch-Caruso, Rita/0000-0002-5993-2799; Meeker, John/0000-0001-8357-5085; Hu, Howard/0000-0002-3676-2707 FU Department of Environmental Health Sciences [R01 ES 007821, P42 ES 05947]; University of Michigan School of Public Health FX This work was supported by R01 ES 007821, P42 ES 05947 Project 1, and a pilot project grant from the Department of Environmental Health Sciences, University of Michigan School of Public Health. NR 52 TC 90 Z9 101 U1 3 U2 24 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2009 VL 117 IS 10 BP 1587 EP 1592 DI 10.1289/ehp.0800522 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 503JI UT WOS:000270529800035 PM 20019910 ER PT J AU Burns, JS Williams, PL Sergeyev, O Korrick, S Lee, MM Revich, B Altshul, L Patterson, DG Turner, WE Needham, LL Saharov, I Hauser, R AF Burns, Jane S. Williams, Paige L. Sergeyev, Oleg Korrick, Susan Lee, Mary M. Revich, Boris Altshul, Larisa Patterson, Donald G., Jr. Turner, Wayman E. Needham, Larry L. Saharov, Igor Hauser, Russ TI Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE children; diet; environment; epidemiology; polychlorinated biphenyls; polychlorinated dibenzodioxins; polychlorinated dibenzofurans ID OPERATION RANCH HAND; DIBENZO-P-DIOXINS; BODY-MASS INDEX; POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE PESTICIDES; FOLLOW-UP; INTERNATIONAL SURVEY; US POPULATION; HALF-LIFE; EXPOSURE AB BACKGROUND: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breastfeeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. OBJECTIVES: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. METHODS: We used general linear regression models to explore associations of log(10)-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. RESULTS: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8-35-0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6). CONCLUSIONS: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant. C1 [Burns, Jane S.; Korrick, Susan; Hauser, Russ] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Environm & Occupat Med & Epidemiol Program, Boston, MA 02115 USA. [Williams, Paige L.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Sergeyev, Oleg] Samara State Med Univ, Dept Phys Educ & Hlth, Samara, Russia. [Sergeyev, Oleg] Chapaevsk Med Assoc, Chapaevsk, Samara Region, Russia. [Korrick, Susan] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Dept Med,Sch Med, Boston, MA 02115 USA. [Lee, Mary M.] Univ Massachusetts, Sch Med, Dept Pediat & Cell Biol, Pediat Endocrine Div, Worcester, MA USA. [Revich, Boris] Russian Acad Sci, Inst Forecasting, Ctr Demog, Moscow, Russia. [Revich, Boris] Russian Acad Sci, Inst Forecasting, Ctr Human Ecol, Moscow, Russia. [Altshul, Larisa] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA. [Patterson, Donald G., Jr.] EnviroSolut Consulting Inc, Jasper, GA USA. [Turner, Wayman E.; Needham, Larry L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Saharov, Igor] Ecol Analyt Ctr, Moscow, Russia. RP Burns, JS (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Environm & Occupat Med & Epidemiol Program, 665 Huntington Ave,Bldg 1,Rm 1404E, Boston, MA 02115 USA. EM jburns@hsph.harvard.edu RI Needham, Larry/E-4930-2011; Sergeyev, Oleg/H-8854-2013; OI Sergeyev, Oleg/0000-0002-5745-3348; Lee, Mary/0000-0002-7204-4884 FU U.S. EPA [R82943701]; NIEHS [ES014370, ES00002, 5T32-ES07069-28] FX This work was funded by U.S. EPA grant R82943701 and NIEHS grants ES014370, ES00002, and 5T32-ES07069-28. NR 56 TC 25 Z9 31 U1 2 U2 9 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2009 VL 117 IS 10 BP 1593 EP 1599 DI 10.1289/ehp.0800223 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 503JI UT WOS:000270529800036 PM 20019911 ER EF