FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Gilboa, SM Correa, A Desrosiers, T Lupo, P Lawson, C Riehle-Colarusso, T Stewart, P Van Winjgaarden, E AF Gilboa, S. M. Correa, A. Desrosiers, T. Lupo, P. Lawson, C. Riehle-Colarusso, T. Stewart, P. Van Winjgaarden, E. TI Maternal Occupational Exposure to Organic Solvents and Congenital Heart Defects: Results from the National Birth Defects Prevention Study, 1997-2002 SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Gilboa, S. M.; Correa, A.; Riehle-Colarusso, T.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Desrosiers, T.] N Carolina Birth Defects Monitoring Program, Raleigh, NC USA. [Lupo, P.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Lawson, C.] CDC, NIOSH, Cincinnati, OH USA. [Stewart, P.] Stenzel Exposure Assessments LLC, Arlington, VA USA. [Van Winjgaarden, E.] Univ Rochester, Rochester, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 366 EP 366 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600078 ER PT J AU Carter, TC Olney, RS Mitchell, AA Romitti, PA Bell, EM Druschel, CM AF Carter, T. C. Olney, R. S. Mitchell, A. A. Romitti, P. A. Bell, E. M. Druschel, C. M. TI Genital Tract Infections during Pregnancy and the Risk of Selected Birth Defects SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Carter, T. C.] NICHHD, NIH, Bethesda, MD 20892 USA. [Olney, R. S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mitchell, A. A.] Boston Univ, Slone Epidemiol Unit, Boston, MA 02215 USA. [Romitti, P. A.] Univ Iowa, Iowa City, IA USA. [Bell, E. M.] SUNY Albany, Albany, NY 12222 USA. [Druschel, C. M.] New York State Dept Hlth, Albany, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 367 EP 367 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600080 ER PT J AU Hartman, RJ Rasmussen, SA Riehle-Colarusso, T Botto, L Correa, A AF Hartman, R. J. Rasmussen, S. A. Riehle-Colarusso, T. Botto, L. Correa, A. TI The Contribution of Chromosomal Abnormalities to Congenital Heart Defects: A Population-Based Study SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Hartman, R. J.; Rasmussen, S. A.; Riehle-Colarusso, T.; Correa, A.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Hartman, R. J.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Botto, L.] Univ Utah, Div Med Genet, Salt Lake City, UT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 369 EP 369 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600083 ER PT J AU Bjornard, K Riehle-Colarusso, TJ Gilboa, SM Correa, A AF Bjornard, K. Riehle-Colarusso, T. J. Gilboa, S. M. Correa, A. TI Patterns in the Prevalence of Congenital Heart Defects, Metropolitan Atlanta, 1978-2005 SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Bjornard, K.; Riehle-Colarusso, T. J.; Gilboa, S. M.; Correa, A.] Natl Ctr Birth Defects & Dev Disabil, CDC, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 396 EP 396 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600134 ER PT J AU Roberts, SS Miller, RK Jones, JK Lindsay, KL Greene, MF Maddrey, WC Williams, IA Liu, J Spiegel, RJ AF Roberts, S. S. Miller, R. K. Jones, J. K. Lindsay, K. L. Greene, M. F. Maddrey, W. C. Williams, I. A. Liu, J. Spiegel, R. J. TI The Ribavirin Pregnancy Registry: Findings After 5 Years of Enrollment SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Roberts, S. S.] UNC Wilmington, Wilmington, NC USA. [Roberts, S. S.] Kendle Int Inc, Wilmington, NC USA. [Miller, R. K.] Univ Rochester, Rochester, NY USA. [Jones, J. K.] Degge Grp Ltd, Arlington, VA USA. [Lindsay, K. L.] Univ So Calif, Los Angeles, CA USA. [Greene, M. F.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Maddrey, W. C.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Williams, I. A.] CDC, Atlanta, GA USA. [Liu, J.] Hoffmann LaRoche, Nutley, NJ USA. [Spiegel, R. J.] Schering Plough Corp, Whitehouse Stn, NJ USA. [Spiegel, R. J.] Merck & Co Inc, Whitehouse Stn, NJ USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 410 EP 410 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600157 ER PT J AU Yeang, HY Hamilton, RG Bernstein, DI Arif, SAM Chow, KS Loke, YH Raulf-Heimsoth, M Wagner, S Breiteneder, H Biagini, RE AF Yeang, H. -Y. Hamilton, R. G. Bernstein, D. I. Arif, S. A. M. Chow, K. -S. Loke, Y. -H. Raulf-Heimsoth, M. Wagner, S. Breiteneder, H. Biagini, R. E. TI Allergen concentration in natural rubber latex (vol 36, pg 1078, 2006) SO CLINICAL AND EXPERIMENTAL ALLERGY LA English DT Correction C1 [Hamilton, R. G.] Johns Hopkins Univ, Sch Med, Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD USA. [Bernstein, D. I.] Univ Cincinnati, Coll Med, Div Allergy Immunol, Cincinnati, OH USA. [Raulf-Heimsoth, M.] Inst Occupat Med, Div Allergy Immunol, Bochum, Germany. [Wagner, S.; Breiteneder, H.] Med Univ Vienna, Dept Pathophysiol, Vienna, Austria. [Biagini, R. E.] NIOSH, Biomonitoring & Hlth Assessment Branch, Cincinnati, OH 45226 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0954-7894 J9 CLIN EXP ALLERGY JI Clin. Exp. Allergy PD MAY PY 2010 VL 40 IS 5 BP 831 EP 831 DI 10.1111/j.1365-2222.2010.03511.x PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 583DA UT WOS:000276651900018 ER PT J AU Whaley, MJ Rose, C Martinez, J Laher, G Sammons, DL Smith, JP Snawder, JE Borrow, R Biagini, RE Plikaytis, B Carlone, GM Romero-Steiner, S AF Whaley, Melissa J. Rose, Charles Martinez, Joseph Laher, Gouri Sammons, Deborah L. Smith, Jerry P. Snawder, John E. Borrow, Ray Biagini, Raymond E. Plikaytis, Brian Carlone, George M. Romero-Steiner, Sandra TI Interlaboratory Comparison of Three Multiplexed Bead-Based Immunoassays for Measuring Serum Antibodies to Pneumococcal Polysaccharides SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; CONCORDANCE CORRELATION-COEFFICIENT; CAPSULAR POLYSACCHARIDES; CONJUGATE VACCINE; SPECIFICITY AB Serotype-specific IgG, as quantified by a standardized WHO enzyme-linked immunosorbent assay (ELISA), is a serologic end point used to evaluate pneumococcal polysaccharide-based vaccine immunogenicity. Antibodies to each vaccine polysaccharide in licensed multivalent vaccines are quantified separately; this is laborious and consumes serum. We compared three bead-based immunoassays: a commercial assay (xMAP Pneumo14; Luminex) and two in-house assays (of the Health Protection Agency [HPA] and Centers for Disease Control and Prevention [CDC]), using the WHO-recommended standard reference and reference sera (n = 11) from vaccinated adults. Multiple comparisons of the IgG concentrations for seven conjugate vaccine serotypes were performed by sample (percent error), serotype (equivalency testing), and laboratory (concordance correlation coefficient [CCC]). When comparing concentrations by sample, bead-based immunoassays generally yielded higher antibody concentrations than the ELISA and had higher variability for serotypes 6B, 18C, and 23F. None of the three assays met the current WHO recommendation of 75% of sera falling within 40% of the assigned antibody concentrations for all seven serotypes. When compared by serotype, the CDC and HPA tests were equivalent for five of seven serotypes, whereas the Luminex assay was equivalent for four of seven serotypes. When overall mean IgG concentrations were compared by laboratory, a higher level of agreement (CCC close to 1) was found among bead-based immunoassays than between the assays and WHO assignments. When compared to WHO assignments, the HPA assay outperformed the other assays (r = 0.920; CCC = 0.894; coefficient of accuracy = 0.972). Additional testing with sera from immunogenicity studies should demonstrate the applicability of this methodology for vaccine evaluation. C1 [Whaley, Melissa J.; Rose, Charles; Martinez, Joseph; Plikaytis, Brian; Carlone, George M.; Romero-Steiner, Sandra] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Laher, Gouri; Borrow, Ray] Manchester Royal Infirm, Hlth Protect Agcy, Vaccine Evaluat Unit, Manchester M13 9WZ, Lancs, England. [Sammons, Deborah L.; Smith, Jerry P.; Snawder, John E.; Biagini, Raymond E.] NIOSH, Biomonitoring & Hlth Assessment Branch, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Romero-Steiner, S (reprint author), Ctr Dis Control & Prevent, Vaccinol Labs, MVPD, DBD, 1600 Clifton Rd,Bldg 18,Room B-105,MS A-36, Atlanta, GA 30333 USA. EM Ssteiner@cdc.gov OI Romero-Steiner, Sandra/0000-0003-4128-7768 FU NIOSH [Y1-ES-0001]; NIEHS [Y1-ES-0001] FX This project was funded in part by an interagency agreement between NIOSH and NIEHS (Y1-ES-0001, Clinical Immunotoxicity). NR 18 TC 14 Z9 15 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2010 VL 17 IS 5 BP 862 EP 869 DI 10.1128/CVI.00022-10 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 590QX UT WOS:000277243200024 PM 20335434 ER PT J AU Waltenburg, RA Kobrynski, LJ Reyes, M Bowen, S Khoury, MJ AF Waltenburg, R. A. Kobrynski, L. J. Reyes, M. Bowen, S. Khoury, M. J. TI Trends in Prevalence of Primary Immunodeficiency Diagnoses, United States 2001-2007 SO CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 1st North American Primary Immune Deficiency National Conference CY MAY 20-23, 2010 CL Philadelphia, PA C1 [Waltenburg, R. A.; Kobrynski, L. J.; Reyes, M.; Bowen, S.; Khoury, M. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD MAY PY 2010 VL 135 IS 2 SI SI MA 41 BP 301 EP 301 PG 1 WC Immunology SC Immunology GA 588ZH UT WOS:000277112900053 ER PT J AU Kirking, HL Cortes, J Burrer, S Hall, AJ Cohen, NJ Lipman, H Kim, C Daly, ER Fishbein, DB AF Kirking, Hannah L. Cortes, Jennifer Burrer, Sherry Hall, Aron J. Cohen, Nicole J. Lipman, Harvey Kim, Curi Daly, Elizabeth R. Fishbein, Daniel B. TI Likely Transmission of Norovirus on an Airplane, October 2008 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID NORWALK VIRUS; UNITED-STATES; OUTBREAKS; GASTROENTERITIS; INFECTION; ILLNESS AB Background. On 8 October 2008, members of a tour group experienced diarrhea and vomiting throughout an airplane flight from Boston, Massachusetts, to Los Angeles, California, resulting in an emergency diversion 3 h after takeoff. An investigation was conducted to determine the cause of the outbreak, assess whether transmission occurred on the airplane, and describe risk factors for transmission. Methods. Passengers and crew were contacted to obtain information about demographics, symptoms, locations on the airplane, and possible risk factors for transmission. Case patients were defined as passengers with vomiting or diarrhea (>= 3 loose stools in 24 h) and were asked to submit stool samples for norovirus testing by real-time reverse-transcription polymerase chain reaction. Results. Thirty-six (88%) of 41 tour group members were interviewed, and 15 (41%) met the case definition (peak date of illness onset, 8 October 2008). Of 106 passengers who were not tour group members, 85 (80%) were interviewed, and 7 (8%) met the case definition after the flight (peak date of illness onset, 10 October 2008). Multivariate logistic regression analysis showed that sitting in an aisle seat (adjusted relative risk, 11.0; 95% confidence interval, 1.4-84.9) and sitting near any tour group member (adjusted relative risk, 7.5; 95% confidence interval, 1.7-33.6) were associated with the development of illness. Norovirus genotype II was detected by reverse-transcription polymerase chain reaction in stool samples from case patients in both groups. Conclusions. Despite the short duration, transmission of norovirus likely occurred during the flight. C1 [Kirking, Hannah L.; Cortes, Jennifer; Burrer, Sherry; Hall, Aron J.; Cohen, Nicole J.; Lipman, Harvey; Kim, Curi; Fishbein, Daniel B.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Burrer, Sherry; Daly, Elizabeth R.] US Dept HHS, Concord, NH USA. RP Fishbein, DB (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS E-03, Atlanta, GA 30333 USA. EM dbf1@cdc.gov NR 21 TC 18 Z9 20 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 1 PY 2010 VL 50 IS 9 BP 1216 EP 1221 DI 10.1086/651597 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 577UA UT WOS:000276248300002 PM 20353365 ER PT J AU Weatherholtz, R Millar, EV Moulton, LH Reid, R Rudolph, K Santosham, M O'Brien, KL AF Weatherholtz, Robert Millar, Eugene V. Moulton, Lawrence H. Reid, Raymond Rudolph, Karen Santosham, Mathuram O'Brien, Katherine L. TI Invasive Pneumococcal Disease a Decade after Pneumococcal Conjugate Vaccine Use in an American Indian Population at High Risk for Disease SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PNEUMONIAE SEROTYPE 19A; ALASKA NATIVE CHILDREN; STREPTOCOCCUS-PNEUMONIAE; NONVACCINE SEROTYPES; UNITED-STATES; ERA; EPIDEMIOLOGY; NAVAJO; INFECTIONS; ADULTS AB Background. Before 7-valent pneumococcal conjugate vaccine (PCV7) introduction, invasive pneumococcal disease (IPD) rates among Navajo were several-fold those of the general US population. Only 50% of IPD cases in children involved PCV7 serotypes. Methods. We conducted active, population-based surveillance for IPD for the period 1995-2006. We documented case characteristics and serotyped the isolates. Results. Over 12-year period, we identified 1508 IPD cases, 447 of which occurred in children aged < 5 years. Rates of IPD due to vaccine serotypes among children aged < 1 year, 1 to < 2 years, and 2 to < 5 years decreased from 210, 263, and 51 cases per 100,000 population, respectively in 1995-1997 to 0 cases in 2004-2006 (P < . 001). Among adults aged >= 65 years, rates of IPD due to vaccine serotypes decreased 81% (95% confidence interval, -98% to -9%; P = .02). Rates of nonvaccine serotype IPD were unchanged in all age strata except for persons aged 18 to < 40 years, among whom the rate decreased by 35% from 27 to 18 cases per 100,000 population (95% confidence interval, -57% to -1%; P = .03). Conclusions. Vaccine-serotype IPD has virtually been eliminated in the PCV7 era among Navajo of all ages. Overall rates of nonvaccine-serotype IPD have not increased, although increases have occurred for some individual types. Rates of all-serotype IPD among Navajo children remain 3-5-fold greater than in the general US population. C1 [Weatherholtz, Robert; Millar, Eugene V.; Moulton, Lawrence H.; Reid, Raymond; Santosham, Mathuram; O'Brien, Katherine L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA. [Santosham, Mathuram; O'Brien, Katherine L.] Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21218 USA. [Rudolph, Karen] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA. RP O'Brien, KL (reprint author), 621 N Washington St, Baltimore, MD 21205 USA. EM klobrien@jhsph.edu OI Moulton, Lawrence/0000-0001-7041-7387 FU Wyeth Vaccines; National Institutes of Health; World Health Organization; Centers for Disease Control and Prevention; Thrasher Research Fund; Merck FX Wyeth Vaccines, National Institutes of Health, World Health Organization, Centers for Disease Control and Prevention, and Thrasher Research Fund; K.L.O. and M. S. have previously received grant support and honoraria from Wyeth Vaccines and Merck. All other authors: no conflicts. NR 19 TC 46 Z9 46 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 1 PY 2010 VL 50 IS 9 BP 1238 EP 1246 DI 10.1086/651680 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 577UA UT WOS:000276248300005 PM 20367225 ER PT J AU Velasquez, MM Ingersoll, KS Sobell, MB Floyd, RL Sobel, LC von Sternberg, K AF Velasquez, Mary M. Ingersoll, Karen S. Sobell, Mark B. Floyd, R. Louise Sobel, Linda Carter von Sternberg, Kirk TI A Dual-Focus Motivational Intervention to Reduce the Risk of Alcohol-Exposed Pregnancy SO COGNITIVE AND BEHAVIORAL PRACTICE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; DRINKERS; CLIENTS AB Project CHOICES developed an integrated behavioral intervention for pi-mention of prenatal alcohol exposure in women at high risk for alcohol-exposed pregnancies. Settings included primary care, university-hospital based obstetrical/gynecology practices, an urban jail, substance abuse treatment settings, and a media-recruited sample in three large cities. The intervention was based on motivational interviewing and targeted both adoption of effective contraception and reduction of alcohol use. Treatment included 4 manual-guided sessions delivered by mental health clinicians and I contraceptive counseling session delivered by a family planning clinician. This paper describes the rationale for treatment; the use of motivational interviewing and the transtheoretical model for a dual-focused approach to behavior change; the development of the Project CHOICES intervention; development of the study protocol and treatment manual; and selection, training, supervision, and monitoring of study counselors. Implications for future applications of the intervention are discussed. C1 [Velasquez, Mary M.; von Sternberg, Kirk] Univ Texas Austin, Austin, TX 78712 USA. [Ingersoll, Karen S.] Univ Virginia, Charlottesville, VA 22903 USA. [Sobell, Mark B.; Sobel, Linda Carter] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Floyd, R. Louise] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Velasquez, MM (reprint author), Univ Stn, D3510, Austin, TX 78712 USA. EM velasquez@mail.utexas.edu FU NIAAA NIH HHS [R01 AA015930-02, R01 AA014356-04S1, R01 AA014356, R01 AA014356-02, R01 AA015930-01, R01 AA014356-03, R01 AA014356-01A2, R01 AA014356-04] NR 26 TC 17 Z9 17 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1077-7229 EI 1878-187X J9 COGN BEHAV PRACT JI Cogn. Behav. Pract. PD MAY PY 2010 VL 17 IS 2 BP 203 EP 212 PG 10 WC Psychology, Clinical SC Psychology GA 587JI UT WOS:000276987000010 PM 20473352 ER PT J AU Lienhardt, C Vernon, A Raviglione, MC AF Lienhardt, Christian Vernon, Andrew Raviglione, Mario C. TI New drugs and new regimens for the treatment of tuberculosis: review of the drug development pipeline and implications for national programmes SO CURRENT OPINION IN PULMONARY MEDICINE LA English DT Article DE drug development; drug-resistant tuberculosis; drug-susceptible tuberculosis; multidrug therapy ID MULTIDRUG-RESISTANT TUBERCULOSIS; EARLY BACTERICIDAL ACTIVITY; HIV-INFECTED PATIENTS; IN-VITRO ACTIVITY; PULMONARY TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; TREATMENT OUTCOMES; ANTIRETROVIRAL THERAPY; DIARYLQUINOLINE TMC207; STERILIZING ACTIVITIES AB Purpose of review The aim is to review briefly the problems related to treatment of drug-susceptible and drug-resistant tuberculosis (TB), describe recent advances in the development of new drugs and new regimens, and discuss implications for control programmes. Recent findings Encouraging advances in TB drug research and development have been made since the turn of the century, resulting in a large number of new products introduced into the global portfolio. Summary Currently, nine compounds at least have advanced to clinical development, including four existing drugs redeveloped for TB indication and five new chemical entities. Present clinical trials are testing new combinations of drugs for a shortened treatment of drug-susceptible TB (<6 months duration) or the safety and efficacy of new drugs in addition to an optimized background therapy for the treatment of multidrug-resistant TB. There are at least 34 compounds or projects in the discovery and preclinical stages, including eight compounds in preclinical development. This increasing development of single compounds underscores the needs for a novel approach to test for optimal drug combinations that would be proposed for treatment of TB in all its forms, and the necessary collaboration of pharmaceutical companies, academia, research institutions, donors, and regulatory authorities. C1 [Lienhardt, Christian; Raviglione, Mario C.] WHO, Stop TB Dept, CH-1211 Geneva, Switzerland. [Lienhardt, Christian] WHO, Stop TB Partnership, CH-1211 Geneva, Switzerland. [Vernon, Andrew] US Ctr Dis Control & Prevent, Div TB Eliminat, Clin & Hlth Syst Res Branch, Atlanta, GA USA. RP Lienhardt, C (reprint author), WHO, Stop TB Dept, CH-1211 Geneva, Switzerland. EM lienhardtc@who.int NR 75 TC 69 Z9 72 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-5287 J9 CURR OPIN PULM MED JI Curr. Opin. Pulm. Med. PD MAY PY 2010 VL 16 IS 3 BP 186 EP 193 DI 10.1097/MCP.0b013e328337580c PG 8 WC Respiratory System SC Respiratory System GA 586ZE UT WOS:000276954000004 PM 20216421 ER PT J AU Siegel, PD Law, BF Fowler, JF Fowler, LM AF Siegel, Paul D. Law, Brandon F. Fowler, Joseph F., Jr. Fowler, Lynn M. TI Disproportionated Rosin Dehydroabietic Acid in Neoprene Surgical Gloves SO DERMATITIS LA English DT Article ID SENSITIZATION; DERMATITIS; EXPERIENCE; ALLERGY AB Background: Allergic contact dermatitis (ACD) is a well-recognized immune-mediated disease often associated with the use of vulcanization accelerator containing latex and nitrite gloves. Potential contact allergens in neoprene (polychloroisoprene, polychloroprene) gloves have not been reported. Objective: The objective was to analyze extracts of neoprene surgical and examination gloves for potential contact allergens. Methods: Four different brands of neoprene-type gloves were purchased, and dichloromethane extracts were derivatized and assayed by gas chromatographic mass spectrometry. A latex surgical glove was used as a negative control. Results: Chemical species consistent with the composition of disproportionated rosin (dehydroabietic acid (MAL didehydroabietic acid, and other pimaric or isopimaric species) were identified in dichloromethane extracts of neoprene gloves. Levels of DHA, a type IV prohapten that can be air oxidized to an active allergen, ranged from 7 to 31 mg/g of glove. A leaching study of DHA was conducted, and small amounts of DHA leached from the glove materials into artificial sweat. DHA oxidation products were not observed in any of the gloves assayed. Conclusion: DHA exposure may occur from neoprene-type glove use, although a potential association with glove ACD has not been established. C1 [Siegel, Paul D.] NIOSH, CDC, Morgantown, WV USA. Univ Louisville, Louisville, KY 40292 USA. RP Siegel, PD (reprint author), NIOSH, CDC, Morgantown, WV USA. FU NIOSH National Research Agenda Intramural FX Funded by a NIOSH National Research Agenda Intramural Grant. NR 12 TC 1 Z9 1 U1 3 U2 12 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1710-3568 J9 DERMATITIS JI Dermatitis PD MAY-JUN PY 2010 VL 21 IS 3 BP 157 EP 159 DI 10.2310/6620.2010.10004 PG 3 WC Dermatology SC Dermatology GA 610TZ UT WOS:000278761500005 PM 20487659 ER PT J AU Li, CY Ford, ES Zhao, GX Balluz, LS Berry, JT Mokdad, AH AF Li, Chaoyang Ford, Earl S. Zhao, Guixiang Balluz, Lina S. Berry, Joyce T. Mokdad, Ali H. TI Undertreatment of Mental Health Problems in Adults With Diagnosed Diabetes and Serious Psychological Distress The Behavioral Risk Factor Surveillance System, 2007 SO DIABETES CARE LA English DT Article ID PREVALENCE AB OBJECTIVE - To assess the prevalence and correlates of undertreatment for mental health problems among adults with diabetes and serious psychological distress (SPD). RESEARCH DESIGN AND METHODS - We analyzed data of adults aged >= 8 years from the 2007 Behavioral Risk Factor Surveillance System. SPD was assessed with the Kessler-6 scale. RESULTS - The prevalence of untreated SPD was estimated to be 2.1 +/- 0.1% (mean +/- SE), 3.4 +/- 0.3%, and 2.0 +/- 0.1% in the total population, diabetic population, and nondiabetic population, respectively. Among people with SPD, those with diagnosed diabetes had a lower rate of undertreatment for mental health problems (45.0%) than those without diabetes (54.9%) (P = 0.002). Nonwhite race/ethnicity, advanced age, lack of health insurance, and currently being employed were associated with increased likelihood of undertreatmera for mental health problems (P < 0.05). CONCLUSIONS - People with diagnosed diabetes may be screened for SPD and treated for specific mental health problems in routine health care. C1 [Li, Chaoyang; Ford, Earl S.; Zhao, Guixiang; Balluz, Lina S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Berry, Joyce T.] Subst Abuse & Mental Hlth Serv Adm, Washington, DC USA. [Mokdad, Ali H.] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA. RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM cli@cdc.gov NR 10 TC 22 Z9 24 U1 0 U2 2 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD MAY PY 2010 VL 33 IS 5 BP 1061 EP 1064 DI 10.2337/dc09-1515 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 595RV UT WOS:000277631200022 PM 20185747 ER PT J AU Burrows, NR Li, YF Geiss, LS AF Burrows, Nilka Rios Li, Yanfeng Geiss, Linda S. TI Incidence of Treatment for End-Stage Renal Disease Among Individuals With Diabetes in the US Continues to Decline Response SO DIABETES CARE LA English DT Letter C1 [Burrows, Nilka Rios; Li, Yanfeng; Geiss, Linda S.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30329 USA. RP Burrows, NR (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30329 USA. EM nrios@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD MAY PY 2010 VL 33 IS 5 BP E70 EP E70 DI 10.2337/dc10-0244 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V26BN UT WOS:000208521200006 ER PT J AU Langer, AJ Feja, K Lasker, BA Hinrikson, HP Morey, RE Pellegrini, GJ Smith, TL Robertson, C AF Langer, Adam J. Feja, Kristina Lasker, Brent A. Hinrikson, Hans P. Morey, Roger E. Pellegrini, Gerald J. Smith, Theresa L. Robertson, Corwin TI Investigation of an apparent outbreak of Rhodococcus equi bacteremia SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Rhodococcus equi; Bacteremia; 16S rRNA gene; DNA Sequencing; MLST ID GORDONIA-TERRAE; INFECTION; IDENTIFICATION; PATHOGEN AB During January to April 2007, hospital staff reported 3 patients with Rhodococcus equi bloodstream infections. Isolates were analyzed at the Centers for Disease Control and Prevention, Atlanta, GA, to confirm identification and to assess strain relatedness; 2 were R. equi but genetically distinct, and 1 was identified as Gordonia polyisoprenivorans. Rapid reference laboratory support prevented an unnecessary outbreak investigation. Published by Elsevier Inc. C1 [Langer, Adam J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Langer, Adam J.; Robertson, Corwin] New Jersey Dept Hlth & Senior Serv, Trenton, NJ 08625 USA. [Feja, Kristina] St Peters Univ Hosp, New Brunswick, NJ 08901 USA. [Feja, Kristina] Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA. [Lasker, Brent A.; Hinrikson, Hans P.; Morey, Roger E.; Pellegrini, Gerald J.; Smith, Theresa L.] Ctr Dis Control & Prevent, Bacterial Zoonoses Branch, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. RP Langer, AJ (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, MS E-10, Atlanta, GA 30333 USA. EM alanger@cdc.gov NR 15 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD MAY PY 2010 VL 67 IS 1 BP 95 EP 100 DI 10.1016/j.diagmicrobio.2010.01.006 PG 6 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 588KS UT WOS:000277069400015 PM 20385352 ER PT J AU Pounder, JI Anderson, CM Voelkerding, KV Salfinger, M Dormandy, J Somoskovi, A Heifets, L Graham, JJ Storts, DR Petti, CA AF Pounder, June I. Anderson, Clint M. Voelkerding, Karl V. Salfinger, Max Dormandy, Jillian Somoskovi, Akos Heifets, Leonid Graham, Jenny Jo Storts, Douglas R. Petti, Cathy A. TI Mycobacterium tuberculosis complex differentiation by genomic deletion patterns with multiplex polymerase chain reaction and melting analysis SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Mycobacterium tuberculosis; Complex differentiation; Multiplex PCR; Real time PCR; Melting analysis; Plexor chemistry ID PERFORMANCE LIQUID-CHROMATOGRAPHY; REAL-TIME PCR; IDENTIFICATION; AFRICANUM; MEMBERS; BOVIS; BCG; DNA AB Differentiation of Mycobacterium tuberculosis complex (MTC) species is important for patient management. We developed a genomic deletion assay based on multiplex polymerase-chain reaction with melting temperature analysis that correctly identified 124 (96%) of 129 MTC isolates. This assay is a fast single-tube method to differentiate members of MTC. (C) 2010 Elsevier Inc. All rights reserved. C1 [Pounder, June I.; Petti, Cathy A.] Associated Reg & Univ Pathologists Inc, Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA. [Anderson, Clint M.] ARUP Labs, Salt Lake City, UT 84108 USA. [Voelkerding, Karl V.; Petti, Cathy A.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84112 USA. [Voelkerding, Karl V.; Petti, Cathy A.] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA. [Salfinger, Max] Florida Dept Hlth, Tallahassee, FL 32399 USA. [Dormandy, Jillian] New York State Dept Hlth, Albany, NY 12202 USA. [Somoskovi, Akos] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Heifets, Leonid; Graham, Jenny Jo] Natl Jewish Ctr, Denver, CO 80206 USA. [Storts, Douglas R.] Promega Corp, Madison, WI 53711 USA. RP Pounder, JI (reprint author), Univ Alaska, Dept Biol Sci, 3101 Sci Circle, Anchorage, AK 99508 USA. EM afjip@uaa.alaska.edu FU ARUP Institute for Clinical and Experimental Pathology FX This study was performed in accordance with the institutional review board at the University of Utah, Salt Lake City, UT. Funding was provided by the ARUP Institute for Clinical and Experimental Pathology. Promega provided Plexor PCR reagents for this study. The authors thank Sam Cohen, Jim Kucera, Wei Tang, and Shale Dames for technical assistance. NR 19 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD MAY PY 2010 VL 67 IS 1 BP 101 EP 105 DI 10.1016/j.diagmicrobio.2009.12.014 PG 5 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 588KS UT WOS:000277069400016 PM 20227227 ER PT J AU Stevens, AM Hennessy, T Baggett, HC Bruden, D Parks, D Klejka, J AF Stevens, A. Michal Hennessy, Thomas Baggett, Henry C. Bruden, Dana Parks, Debbie Klejka, Joseph TI Methicillin-Resistant Staphylococcus aureus Carriage and Risk Factors for Skin Infections, Southwestern Alaska, USA SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PANTON-VALENTINE LEUKOCIDIN; NASAL CARRIAGE; FOOTBALL TEAM; RURAL ALASKA; COMMUNITY; OUTBREAK; COLONIZATION; EPIDEMIOLOGY; STRAINS; SPREAD AB Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are common in southwestern Alaska. Outbreak strains have been shown to carry the genes for Panton-Valentine leukocidin (PVL). To determine if carriage of PVL-positive CA-MRSA increased the risk for subsequent soft tissue infection, we conducted a retrospective cohort study by reviewing the medical records of 316 persons for 3.6 years after their participation in a MRSA nasal colonization survey. Demographic, nasal carriage, and antimicrobial drug use data were analyzed for association with skin infection risk. Skin infections were more likely to develop in MRSA carriers than in methicillin-susceptible S. aureus carriers or noncarriers of S. aureus during the first follow-up year, but not in subsequent years. Repeated skin infections were more common among MRSA carriers. In an area where PVL-containing MRSA is prevalent, skin infection risk was increased among MRSA nasal carriers compared with methicillin-susceptible S.aureus carriers and noncarriers, but risk differential diminished over time. C1 [Stevens, A. Michal; Hennessy, Thomas; Bruden, Dana; Parks, Debbie] Ctr Dis Control & Prevent, Anchorage, AK 99508 USA. [Baggett, Henry C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Klejka, Joseph] Yukon Kuskokwim Heath Corp, Bethel, AK USA. RP Hennessy, T (reprint author), Ctr Dis Control & Prevent, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA. EM thennessy@cdc.gov NR 29 TC 18 Z9 20 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 797 EP 803 DI 10.3201/eid1605.090851 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900007 PM 20409369 ER PT J AU Armstrong, KE McNabb, SJN Ferland, LD Stephens, T Muldoon, A Fernandez, JA Ostroff, S AF Armstrong, Kia E. McNabb, Scott J. N. Ferland, Lisa D. Stephens, Tim Muldoon, Anna Fernandez, Jose A. Ostroff, Stephen TI Capacity of Public Health Surveillance to Comply with Revised International Health Regulations, USA SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TIMELINESS AB Public health surveillance is essential for detecting and responding to infectious diseases and necessary for compliance with the revised International Health Regulations (IHR) 2005. To assess reporting capacities and compliance with IHR of all 50 states and Washington, DC, we sent a questionnaire to respective epidemiologists; 47 of 51 responded. Overall reporting capacity was high. Eighty-one percent of respondents reported being able to transmit notifications about unknown or unexpected events to the Centers for Disease Control and Prevention (CDC) daily. Additionally, 80% of respondents reported use of a risk assessment tool to determine whether CDC should be notified of possible public health emergencies. These findings suggest that most states have systems in place to ensure compliance with IHR. However, full state-level compliance will require additional efforts. C1 [Armstrong, Kia E.; McNabb, Scott J. N.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ferland, Lisa D.] Council State & Territorial Epidemiologists, Atlanta, GA USA. [Stephens, Tim; Muldoon, Anna; Fernandez, Jose A.] US Dept Hlth & Human Serv, Washington, DC USA. [Ostroff, Stephen] Penn Dept Hlth, Harrisburg, PA 17108 USA. RP Armstrong, KE (reprint author), TB Control Program, Div Publ Hlth, 1905 Mail Serv Ctr, Raleigh, NC 27699 USA. EM karmstrong1@cdc.gov FU CDC, Atlanta, GA [1U38HM000414] FX This publication was supported by Cooperative Agreement No. 1U38HM000414, CDC, Atlanta, GA. NR 9 TC 4 Z9 4 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 804 EP 808 DI 10.3201/eid1605.091127 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900008 PM 20409370 ER PT J AU Aradaib, IE Erickson, BR Mustafa, ME Khristova, ML Saeed, NS Elageb, RM Nichol, ST AF Aradaib, Imadeldin E. Erickson, Bobbie R. Mustafa, Mubarak E. Khristova, Marina L. Saeed, Nageeb S. Elageb, Rehab M. Nichol, Stuart T. TI Nosocomial Outbreak of Crimean-Congo Hemorrhagic Fever, Sudan SO EMERGING INFECTIOUS DISEASES LA English DT Article ID VIRUS; PROVINCE AB To confirm the presence of Crimean-Congo hemorrhagic fever in Sudan, we tested serum of 8 patients with hemorrhagic fever in a rural hospital in 2008. Reverse transcription-PCR identified Crimean-Congo hemorrhagic fever virus. Its identification as group III lineage indicated links to virus strains from South Africa, Mauritania, and Nigeria. C1 [Erickson, Bobbie R.; Khristova, Marina L.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Aradaib, Imadeldin E.] Univ Khartoum, Khartoum, Sudan. [Aradaib, Imadeldin E.] Natl Ribat Univ, Khartoum, Sudan. [Mustafa, Mubarak E.] Cent Publ Hlth Lab, Khartoum, Sudan. [Mustafa, Mubarak E.] Juba Univ, Khartoum, Sudan. [Saeed, Nageeb S.] Fed Minist Hlth, Khartoum, Sudan. [Saeed, Nageeb S.; Elageb, Rehab M.] Natl Med Lab, Khartoum, Sudan. RP Nichol, ST (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G14, Atlanta, GA 30333 USA. EM snichol@cdc.gov NR 15 TC 37 Z9 39 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 837 EP 839 DI 10.3201/eid1605.091815 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900015 PM 20409377 ER PT J AU Lambert, AJ Blair, CD D'Anton, M Ewing, W Harborth, M Seiferth, R Xiang, J Lanciotti, RS AF Lambert, Amy J. Blair, Carol D. D'Anton, Mary Ewing, Winnann Harborth, Michelle Seiferth, Robyn Xiang, Jeannie Lanciotti, Robert S. TI La Crosse Virus in Aedes albopictus Mosquitoes, Texas, USA, 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; CALIFORNIA SEROGROUP; BUNYAVIRIDAE; ORTHOBUNYAVIRUS AB We report the arthropod-borne pediatric encephalitic agent La Crosse virus in Aedes albopictus mosquitoes collected in Dallas County, Texas, USA, in August 2009. The presence of this virus in an invasive vector species within a region that lies outside the virus's historically recognized geographic range is of public health concern. C1 [Lambert, Amy J.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Ft Collins, CO 80521 USA. [Blair, Carol D.] Colorado State Univ, Ft Collins, CO 80523 USA. [D'Anton, Mary; Ewing, Winnann; Harborth, Michelle; Seiferth, Robyn; Xiang, Jeannie] Texas Dept State Hlth Serv, Austin, TX USA. RP Lambert, AJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Rampart Rd, Ft Collins, CO 80521 USA. EM ahk7@cdc.gov NR 13 TC 18 Z9 19 U1 0 U2 13 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 856 EP 858 DI 10.3201/eid1605.100170 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900021 PM 20409384 ER PT J AU Morgan, OW Brunette, G Kapella, BK McAuliffe, I Katongole-Mbidde, E Li, WK Marano, N Okware, S Olsen, SJ Secor, WE Tappero, JW Wilkins, PP Montgomery, SP AF Morgan, Oliver W. Brunette, Gary Kapella, Bryan K. McAuliffe, Isabel Katongole-Mbidde, Edward Li, Wenkai Marano, Nina Okware, Sam Olsen, Sonja J. Secor, W. Evan Tappero, Jordan W. Wilkins, Patricia P. Montgomery, Susan P. TI Schistosomiasis among Recreational Users of Upper Nile River, Uganda, 2007 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID OMO RIVER; ETHIOPIA; OUTBREAK; AFRICA AB After recreational exposure to river water in Uganda, 12 (17%) of 69 persons had evidence of schistosome infection. Eighteen percent self-medicated with praziquantel prophylaxis immediately after exposure, which was not appropriate. Travelers to schistosomiasis-endemic areas should consult a travel medicine physician. C1 [Morgan, Oliver W.; Brunette, Gary; Kapella, Bryan K.; McAuliffe, Isabel; Li, Wenkai; Marano, Nina; Olsen, Sonja J.; Secor, W. Evan; Tappero, Jordan W.; Wilkins, Patricia P.; Montgomery, Susan P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Katongole-Mbidde, Edward] Uganda Virus Res Inst, Entebbe, Uganda. [Okware, Sam] Minist Hlth, Kampala, Uganda. RP Morgan, OW (reprint author), Ctr Dis Control & Prevent, Mailstop C12,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM omorgan@cdc.gov NR 16 TC 4 Z9 4 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 866 EP 868 DI 10.3201/eid1605.091740 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900024 PM 20409387 ER PT J AU Stimpert, KK Montgomery, SP AF Stimpert, Kelly K. Montgomery, Susan P. TI Physician Awareness of Chagas Disease, USA SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID TRYPANOSOMA-CRUZI; LOS-ANGELES; TRANSPLANTATION; TRANSMISSION C1 [Stimpert, Kelly K.; Montgomery, Susan P.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Stimpert, Kelly K.] Atlanta Res & Educ Fdn, Atlanta, GA USA. RP Stimpert, KK (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F22, Atlanta, GA 30341 USA. EM kkstimpert@cdc.gov NR 7 TC 23 Z9 23 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 871 EP 872 DI 10.3201/eid1605.091440 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900026 PM 20409389 ER PT J AU Rodriguez, EL Tomashek, KM Gregory, CJ Munoz, J Hunsperger, E Lorenzi, OD Irizarry, JG Garcia-Gubern, C AF Rodriguez, Eric Lopez Tomashek, Kay M. Gregory, Christopher J. Munoz, Jorge Hunsperger, Elizabeth Lorenzi, Olga D. Irizarry, Jorge Gutierrez Garcia-Gubern, Carlos TI Co-infection with Dengue Virus and Pandemic (H1N1) 2009 Virus SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID ASSAY C1 [Tomashek, Kay M.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. [Rodriguez, Eric Lopez; Irizarry, Jorge Gutierrez; Garcia-Gubern, Carlos] Hosp San Lucas, Ponce Sch Med, Ponce, PR USA. RP Tomashek, KM (reprint author), Ctr Dis Control & Prevent, Dengue Branch, 1324 Calle Canada, San Juan, PR 00920 USA. EM kct9@cdc.gov NR 10 TC 7 Z9 7 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 882 EP 884 DI 10.3201/eid1605.091920 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900032 ER PT J AU Hicks, LA Monnet, DL Roberts, RM AF Hicks, Lauri A. Monnet, Dominique L. Roberts, Rebecca M. TI Increase in Pneumococcus Macrolide Resistance, USA SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID STREPTOCOCCUS-PNEUMONIAE C1 [Hicks, Lauri A.; Roberts, Rebecca M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Monnet, Dominique L.] European Ctr Dis Prevent & Control, Stockholm, Sweden. RP Hicks, LA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop C23, Atlanta, GA 30333 USA. EM auq3@cdc.gov NR 5 TC 1 Z9 1 U1 1 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 896 EP 897 DI 10.3201/eid1605.091424 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900040 PM 20409403 ER PT J AU Potter, P AF Potter, Polyxeni TI The Whole Heaven a Musical Scale and a Number SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM PMP1@cdc.gov NR 6 TC 1 Z9 1 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2010 VL 16 IS 5 BP 905 EP 906 DI 10.3201/eid1605.000000 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 590FK UT WOS:000277209900045 PM 20409407 ER PT J AU Thompson, J Lorber, M Toms, LML Kato, K Calafat, AM Mueller, JF AF Thompson, Jack Lorber, Matthew Toms, Leisa-Maree L. Kato, Kayoko Calafat, Antonia M. Mueller, Jochen F. TI Use of simple pharmacokinetic modeling to characterize exposure of Australians to perfluorooctanoic acid and perfluorooctane sulfonic acid SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Perfluorooctanoic acid; PFOA; Perfluorooctane sulfonic acid; PFOS; Pharmacokinetic modeling; Blood monitoring; Australia ID AMMONIUM PERFLUOROOCTANOATE; POLYFLUOROALKYL CHEMICALS; COMMUNITY EXPOSURE; CYNOMOLGUS MONKEYS; SERUM-LEVELS; PERSPECTIVES; POPULATION; TOXICITY; WORKERS; HEALTH AB Perflurooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) have been used for a variety of applications including fluoropolymer processing, fire-fighting foams and surface treatments since the 1950s. Both PFOS and PFOA are polyfluoroalkyl chemicals (PFCs), man-made compounds that are persistent in the environment and humans; some PFCs have shown adverse effects in laboratory animals. Here we describe the application of a simple one compartment pharmacokinetic model to estimate total intakes of PFOA and PFOS for the general population of urban areas on the east coast of Australia. Key parameters for this model include the elimination rate constants and the volume of distribution within the body. A volume of distribution was calibrated for PFOA to a value of 170 ml/kg bw using data from two communities in the United States where the residents' serum concentrations could be assumed to result primarily from a known and characterized source, drinking water contaminated with PFOA by a single fluoropolymer manufacturing facility. For PFOS, a value of 230 ml/kg bw was used, based on adjustment of the PFOA value. Applying measured Australian serum data to the model gave mean standard deviation intake estimates of PFOA of 1.6 +/- 0.3 ng/kg bw/day for males and females >12 years of age combined based on samples collected in 2002-2003 and 1.3 +/- 0.2 ng/kg bw/day based on samples collected in 2006-2007. Mean intakes of PFOS were 2.7 +/- 0.5 ng/kg bw/day for males and females >12 years of age combined based on samples collected in 2002-2003, and 2.4 +/- 0.5 ng/kg bw/day for the 2006-2007 samples. ANOVA analysis was run for PFOA intake and demonstrated significant differences by age group (p = 0.03), sex (p = 0.001) and date of collection (p < 0.001). Estimated intake rates were highest in those aged >60 years, higher in males compared to females, and higher in 2002-2003 compared to 2006-2007. The same results were seen for PFOS intake with significant differences by age group (p<0.001), sex (p = 0.001) and date of collection (p = 0.016). (C) 2010 Elsevier Ltd. All rights reserved. C1 [Thompson, Jack; Toms, Leisa-Maree L.; Mueller, Jochen F.] Univ Queensland, Natl Res Ctr Environm Toxicol, Coopers Plains, Qld 4108, Australia. [Lorber, Matthew] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Kato, Kayoko; Calafat, Antonia M.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Thompson, J (reprint author), Univ Queensland, Natl Res Ctr Environm Toxicol, 39 Kessels Rd, Coopers Plains, Qld 4108, Australia. EM jthompson@entox.uq.edu.au RI Mueller, Jochen/C-6241-2008; Thompson, Jack/A-8825-2011; Toms, Leisa-Maree/C-9530-2009; OI Toms, Leisa-Maree/0000-0002-1444-1638; Mueller, Jochen/0000-0002-0000-1973 NR 41 TC 33 Z9 34 U1 2 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 J9 ENVIRON INT JI Environ. Int. PD MAY PY 2010 VL 36 IS 4 BP 390 EP 397 DI 10.1016/j.envint.2010.02.008 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 594HE UT WOS:000277526200012 PM 20236705 ER PT J AU Calafat, AM Ye, XY Wong, LY Bishop, AM Needham, LL AF Calafat, Antonia M. Ye, Xiaoyun Wong, Lee-Yang Bishop, Amber M. Needham, Larry L. TI Urinary Concentrations of Four Parabens in the US Population: NHANES 2005-2006 SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE biomonitoring; exposure; human; NHANES; p-hydroxybenzoic acid esters; urine ID PARA-HYDROXYBENZOIC ACID; HUMAN HEALTH; PRACTICAL USAGE; NATIONAL-HEALTH; BIOLOGICAL FATE; BREAST-CANCER; ETHYL PARABEN; COSMETICS; HUMANS; SKIN AB BACKGROUND: Parabens are widely used as antimicrobial preservatives in cosmetics, pharmaceuticals, and food and beverage processing. OBJECTIVES: We assessed exposure to methyl, ethyl, propyl, and butyl parabens in a representative sample of persons >= 6 years of age in the U.S. general population from the 2005-2006 National Health and Nutrition Examination Survey. METHODS: We analyzed 2,548 urine samples by using online solid-phase extraction coupled to isotope dilution-high-performance liquid chromatography/tandem mass spectrometry. RESULTS: We detected methyl paraben (MP) and propyl paraben (PP) in 99.1% and 92.7% of the samples, respectively. We detected ethyl (42.4%) and butyl (47%) parabens less frequently and at median concentrations at least one order of magnitude lower than MP (63.5 mu g/L) and PP (8.7 mu g/L). Least-square geometric mean (LSGM) concentrations of MP were significantly higher (p <= 0.01) among non-Hispanic blacks than among non-Hispanic whites except at older ages (>= 60 years). Adolescent and adult females had significantly higher (p < 0.01) LSGM concentrations of MP and PP than did adolescent and adult males. Females were more likely than males [adjusted odds ratios (ORs) and 95% confidence intervals (CIs): MP, 3.2 (2.99-5.27); PP, 4.19 (2.34-7.49)] and non-Hispanic blacks were more likely than non-Hispanic whites [MP, 4.99 (2.62-9.50); PP, 3.6 (1.86-7.05)] to have concentrations above the 95th percentile. CONCLUSIONS: The general U.S. population was exposed to several parabens during 2005-2006. Differences in the urinary concentrations of MP and PP by sex and race/ethnicity likely reflect the use of personal care products containing these compounds. C1 [Calafat, Antonia M.; Ye, Xiaoyun; Wong, Lee-Yang; Bishop, Amber M.; Needham, Larry L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. RP Calafat, AM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy NE,Mailstop F53, Atlanta, GA 30341 USA. EM Acalafat@cdc.gov RI Needham, Larry/E-4930-2011 NR 33 TC 111 Z9 113 U1 5 U2 42 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2010 VL 118 IS 5 BP 679 EP 685 DI 10.1289/ehp.0901560 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 598OF UT WOS:000277846800034 PM 20056562 ER PT J AU Harley, KG Marks, AR Chevrier, J Bradman, A Sjodin, A Eskenazi, B AF Harley, Kim G. Marks, Amy R. Chevrier, Jonathan Bradman, Asa Sjoedin, Andreas Eskenazi, Brenda TI PBDE Concentrations in Women's Serum and Fecundability SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE fecundability; flame retardants; menstrual cycle characteristics; PBDEs; time to pregnancy ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; POLYCHLORINATED-BIPHENYLS PCBS; NEONATAL BRAIN-DEVELOPMENT; MENSTRUAL-CYCLE LENGTH; THYROID-HORMONE; DEVELOPMENTAL EXPOSURE; ADULT MICE; SPONTANEOUS BEHAVIOR; UNITED-STATES AB BACKGROUND: Exposure to polybrominated diphenyl ether (PBDE) flame retardants is widespread, with 97% of Americans having detectable levels. Although PBDEs have been associated with reproductive and hormonal effects in animals, no human studies have examined their association with fertility. OBJECTIVES: This study was designed to determine whether maternal concentrations of PBDEs in serum collected during pregnancy are associated with time to pregnancy and menstrual cycle characteristics. METHODS: Pregnant women (n = 223) living in a low-income, predominantly Mexican-immigrant community in California were interviewed to determine how many months they took to become pregnant. Blood samples were collected and analyzed for PBDEs. PBDE concentrations were lipid adjusted and log(10) transformed. Analyses were limited to PBDE congeners detected in > 75% of the population (BDEs 47, 99, 100, 153). Cox proportional hazards models modified for discrete time were used to obtain fecundability odds ratios (fORs) for the association of PBDEs and time to pregnancy. RESULTS: We detected all four congeners in > 97% of women. Increasing levels of BDEs 47, 99, 100, 153 and the sum of these four congeners were all associated with longer time to pregnancy. We observed significantly reduced fORs for BDE-100 [adjusted fOR = 0.6; 95% confidence interval (CI), 0.4-0.9], BDE-153 (adjusted fOR = 0.5; 95% CI, 0.3-0.8), and the sum of the four congeners (adjusted fOR = 0.7; 95% CI, 0.5-1.0). PBDEs were not associated with menstrual cycle characteristics. CONCLUSIONS: We found significant decreases in fecundability associated with PBDE exposure in women. Future studies are needed to replicate and confirm this finding. C1 [Harley, Kim G.; Marks, Amy R.; Chevrier, Jonathan; Bradman, Asa; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94704 USA. [Sjoedin, Andreas] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Harley, KG (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, 2150 Shattuck Ave,Suite 600, Berkeley, CA 94704 USA. EM kharley@berkeley.edu RI Sjodin, Andreas/F-2464-2010; OI Marks, Amy/0000-0002-3047-5379 FU National Institute of Environmental Health Sciences (NIEHS) [P01 ES009605, R01 ES015572]; U.S. Environmental Protection Agency (EPA) [RD 826709-01-1] FX This work was supported by P01 ES009605 and R01 ES015572 from the National Institute of Environmental Health Sciences (NIEHS) and RD 826709-01-1 from the U.S. Environmental Protection Agency (EPA). NR 60 TC 123 Z9 131 U1 2 U2 30 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2010 VL 118 IS 5 BP 699 EP 704 DI 10.1289/ehp.0901450 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 598OF UT WOS:000277846800037 PM 20103495 ER PT J AU Herbstman, JB Sjodin, A Kurzon, M Lederman, SA Jones, RS Rauh, V Needham, LL Tang, D Niedzwiecki, M Wang, RY Perera, F AF Herbstman, Julie B. Sjoedin, Andreas Kurzon, Matthew Lederman, Sally A. Jones, Richard S. Rauh, Virginia Needham, Larry L. Tang, Deliang Niedzwiecki, Megan Wang, Richard Y. Perera, Frederica TI Prenatal Exposure to PBDEs and Neurodevelopment SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE biomarkers; children; neurodevelopment; PBDEs; polybrominated diphenyl ethers; prenatal; World Trade Center; WTC ID POLYBROMINATED DIPHENYL ETHERS; WORLD-TRADE-CENTER; BROMINATED FLAME RETARDANTS; THYROID-HORMONE LEVELS; POLYCHLORINATED-BIPHENYLS; ENDOCRINE DISRUPTERS; CHILD-DEVELOPMENT; BRAIN-DEVELOPMENT; LOWER MANHATTAN; HOUSE-DUST AB BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are widely used flame retardant compounds that are persistent and bioaccumulative and therefore have become ubiquitous environment contaminants. Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects. OBJECTIVE: In a longitudinal cohort initiated after 11 September 2001, including 329 mothers who delivered in one of three hospitals in lower Manhattan, New York, we examined prenatal PBDE exposure and neurodevelopment when their children were 12-48 and 72 months of age. METHODS: We analyzed 210 cord blood specimens for selected PBDE congeners and assessed neuro-developmental effects in the children at 12-48 and 72 months of age; 118, 117, 114, 104, and 96 children with available cord PBDE measurements were assessed at 12, 24, 36, 48, and 72 months, respectively. We used multivariate regression analyses to evaluate the associations between concentrations of individual PBDE congeners and neurodevelopmental indices. RESULTS: Median cord blood concentrations of PBDE congeners 47, 99, and 100 were 11.2, 3.2, and 1.4 ng/g lipid, respectively. After adjustment for potential confounders, children with higher concentrations of BDEs 47, 99, or 100 scored lower on tests of mental and physical development at 12-48 and 72 months. Associations were significant for 12-month Psychomotor Development Index (BDE-47), 24-month Mental Development Index (MDI) (BDE-47, 99, and 100), 36-month MDI (BDE-100), 48-month full-scale and verbal IQ (BDE-47, 99, and 100) and performance IQ (BDE-100), and 72-month performance IQ (BDE-100). CONCLUSIONS: This epidemiologic study demonstrates neurodevelopmental effects in relation to cord blood PBDE concentrations. Confirmation is needed in other longitudinal studies. C1 [Herbstman, Julie B.; Kurzon, Matthew; Lederman, Sally A.; Rauh, Virginia; Tang, Deliang; Niedzwiecki, Megan; Perera, Frederica] Columbia Univ, Mailman Sch Publ Hlth, Columbia Ctr Childrens Environm Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA. [Sjoedin, Andreas; Jones, Richard S.; Needham, Larry L.; Wang, Richard Y.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Herbstman, JB (reprint author), Columbia Univ, Mailman Sch Publ Hlth, Columbia Ctr Childrens Environm Hlth, Dept Environm Hlth Sci, 100 Haven Ave 25F, New York, NY 10032 USA. EM jh2678@columbia.edu RI Sjodin, Andreas/F-2464-2010; Needham, Larry/E-4930-2011 FU New York Community Trust and United Way of New York City; New York Times 9/11 Neediest Fund; National Philanthropic Trust; National Institute of Environmental Health Sciences [ES09089, 5P01 ES09600, 5R01 ES08977]; U.S. Environmental Protection Agency [R827027] FX This research was supported by the September 11th Fund of the New York Community Trust and United Way of New York City; the New York Times 9/11 Neediest Fund; the National Philanthropic Trust; National Institute of Environmental Health Sciences grants ES09089, 5P01 ES09600, and 5R01 ES08977, and U.S. Environmental Protection Agency grant R827027. NR 47 TC 305 Z9 319 U1 8 U2 74 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2010 VL 118 IS 5 BP 712 EP 719 DI 10.1289/ehp.0901340 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 598OF UT WOS:000277846800039 PM 20056561 ER PT J AU Lakind, JS Richardson, SD Blount, BC AF Lakind, Judy S. Richardson, Susan D. Blount, Benjamin C. TI The Good, the Bad, and the Volatile: Can We Have Both Healthy Pools and Healthy People? SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID INDOOR SWIMMING POOLS; DISINFECTION BY-PRODUCTS; RECREATIONAL WATER; UNITED-STATES; ASTHMA; RISK; EXPOSURE; CHLOROFORM; SYMPTOMS; CHILDREN C1 [Lakind, Judy S.] Univ Maryland, Sch Med, LaKind Associates LLC, Baltimore, MD 21201 USA. [Richardson, Susan D.] US EPA, Natl Exposure Res Lab, Athens, GA USA. [Blount, Benjamin C.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lakind, JS (reprint author), Univ Maryland, Sch Med, LaKind Associates LLC, Baltimore, MD 21201 USA. EM lakindassoc@comcast.net FU Research Foundation for Health and Environmental Effects (RFHEE) FX J. L. received support for this manuscript from the Research Foundation for Health and Environmental Effects (RFHEE). RFHEE was not involved in the design, collection, management, analysis, or interpretation of the data; or in the preparation or approval of the manuscript. This paper has been reviewed in accordance with the U.S. EPA's peer and administrative review policies and approved for publication. the findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of RFHEE or the official positions of the CDC or the U.S. EPA. NR 45 TC 26 Z9 26 U1 4 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 1 PY 2010 VL 44 IS 9 BP 3205 EP 3210 DI 10.1021/es903241k PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 588JX UT WOS:000277067000005 PM 20222731 ER PT J AU Kellen, AJ Reed, C Patton, M Arnold, KE Finelli, L Hageman, J AF Kellen, A. J. Reed, C. Patton, M. Arnold, K. E. Finelli, L. Hageman, J. TI Staphylococcus aureus community-onset pneumonia in patients admitted to children's hospitals during autumn and winter of 2006-2007 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Antimicrobial resistance; paediatric pneumonia; S. aureus ID PANTON-VALENTINE LEUKOCIDIN; ACQUIRED PNEUMONIA; INFLUENZA SEASON; UNITED-STATES; ADULTS; MORTALITY; EPIDEMIC AB Staphylococcus aureus is a relatively uncommon cause of community-onset pneumonia (COP) that may complicate influenza infection. We reviewed admissions to children's hospitals to describe more systematically this entity. Records of patients hospitalized at three children's hospitals between 1 October 2006 and 30 April 2007 who had a positive S. aureus culture from a sterile site or respiratory specimen were reviewed and data were abstracted for episodes of primary S. aureus COP. Overall, 30 episodes met criteria for primary S. aureus COP; 12 (41%) involved methicillin-resistant S. aureus. Patients in 11 (37%) episodes were seen by a healthcare provider for their symptoms prior to hospital admission; three received an antimicrobial, none of which had activity against the S. aureus isolated. Mechanical ventilation was required in 21 (70%) episodes; five (17%) patients died. When evaluating patients with severe COP, providers should be aware of the potential for S. aureus, including methicillin-resistant strains. C1 [Kellen, A. J.; Hageman, J.] Natl Ctr Preparedness Detect & Control Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. [Kellen, A. J.; Reed, C.] Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA. [Reed, C.; Patton, M.; Finelli, L.] Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA. [Patton, M.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA. [Arnold, K. E.] Georgia Dept Human Resources, Div Publ Hlth, Atlanta, GA USA. RP Kellen, AJ (reprint author), 1600 Clifton Rd NE,MS A-35, Atlanta, GA 30333 USA. EM AKallen@cdc.gov NR 21 TC 2 Z9 2 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAY PY 2010 VL 138 IS 5 SI SI BP 666 EP 672 DI 10.1017/S095026880999135X PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 593XN UT WOS:000277496400007 ER PT J AU Sircar, KD Bancroft, E Nguyen, DM Mascola, L AF Sircar, K. D. Bancroft, E. Nguyen, D. M. Mascola, L. TI Hospitalization of paediatric patients for methicillin-resistant Staphylococcus aureus skin and soft-tissue infection, 1998-2006 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Methicillin-resistant S. aureus (MRSA); surveillance; Staphylococcus aureus; skin infections ID DISCHARGE DATA; UNITED-STATES AB Hospital discharge reports have provided data for studies of methicillin-resistant Staphylococcus aureus (M RSA) skin and soft-tissue infection (SSTI) studies. This analysis determined the sensitivity and positive predictive value of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code combinations to calculate hospitalization incidence rates, representativeness of a set of three ICD-9-CM codes to define M RSA SSTI, and hospitalization incidence rate trends for paediatric M RSA SSTIs in Los Angeles County (LAC). Using 133 cases from 31 hospitals, we found that the set of three ICD-9-CM codes used to define laboratory-confirmed cases had one of the highest positive predictive values (49%). There was no difference in age and race between those categorized using three codes vs. other code combinations. A dramatic increase in paediatric MRSA SSTI cases occurred in LAC during 1998-2006. We conclude that this combination of codes may be used to determine the rise of MRSA SSTIs in paediatric populations. C1 [Sircar, K. D.; Nguyen, D. M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Bancroft, E.; Mascola, L.] Dept Publ Hlth, Los Angeles, CA USA. RP Sircar, KD (reprint author), 313 N Figueroa St,Room 212, Los Angeles, CA 90012 USA. EM ddq0@cdc.gov NR 8 TC 6 Z9 6 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAY PY 2010 VL 138 IS 5 SI SI BP 677 EP 682 DI 10.1017/S095026880999121X PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 593XN UT WOS:000277496400009 PM 19919731 ER PT J AU Ferguson, PL Smith, GM Wannamaker, BB Thurman, DJ Pickelsimer, EE Selassie, AW AF Ferguson, Pamela L. Smith, Gigi M. Wannamaker, Braxton B. Thurman, David J. Pickelsimer, E. Elisabeth Selassie, Anbesaw W. TI A population-based study of risk of epilepsy after hospitalization for traumatic brain injury SO EPILEPSIA LA English DT Article DE Posttraumatic epilepsy; Traumatic brain injuries; Incidence cohort studies; Population surveillance; Depressive disorder ID LATE POSTTRAUMATIC SEIZURES; UNPROVOKED SEIZURES; MAJOR DEPRESSION; SOUTH-CAROLINA; HEAD-INJURY; HIPPOCAMPAL VOLUME; ADULTS; PREVALENCE; COMMUNITY; EPIDEMIOLOGY AB P>Purpose: This study was undertaken to determine the risk of developing posttraumatic epilepsy (PTE) within 3 years after discharge among a population-based sample of older adolescents and adults hospitalized with traumatic brain injury (TBI) in South Carolina. It also identifies characteristics related to development of PTE within this population. Methods: A stratified random sample of persons aged 15 and older with TBI was selected from the South Carolina nonfederal hospital discharge dataset for four consecutive years. Medical records of recruits were reviewed, and they participated in up to three yearly follow-up telephone interviews. Results: The cumulative incidence of PTE in the first 3 years after discharge, after adjusting for loss to follow-up, was 4.4 per 100 persons over 3 years for hospitalized mild TBI, 7.6 for moderate, and 13.6 for severe. Those with severe TBI, posttraumatic seizures prior to discharge, and a history of depression were most at risk for PTE. This higher risk group also included persons with three or more chronic medical conditions at discharge. Discussion: These results raise the possibility that although some of the characteristics related to development of PTE are nonmodifiable, other factors, such as depression, might be altered with intervention. Further research into factors associated with developing PTE could lead to risk-reducing treatments. C1 [Ferguson, Pamela L.; Pickelsimer, E. Elisabeth; Selassie, Anbesaw W.] Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA. [Smith, Gigi M.; Wannamaker, Braxton B.] Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USA. [Smith, Gigi M.] Med Univ S Carolina, Coll Nursing, Charleston, SC 29425 USA. [Thurman, David J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Ferguson, PL (reprint author), Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, 135 Cannon St,Suite 303,MSC 835, Charleston, SC 29425 USA. EM ferguspl@musc.edu FU Division of Injury Response, National Center for Injury Prevention and Control (NCIPC) [U17/CCU421926]; National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP); Centers for Disease Control and Prevention (CDC) FX This study was supported by cooperative agreement U17/CCU421926 (PI: Anbesaw W. Selassie) from the Division of Injury Response, National Center for Injury Prevention and Control (NCIPC), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Centers for Disease Control and Prevention (CDC). The study was performed pursuant to a jointly financed cooperative arrangement between the NCPIC, the NCCDPHP, CDC, and the Social Security Administration (SSA), Office of Disability Income and Support Programs. The opinions and conclusions expressed are solely the authors' and should not be construed as representing the opinions or policy of CDC, SSA, or any agency of the federal government.We would like to thank the individuals at the SC Office of Research and Statistics and the SC Department of Health and Environmental Control who were invaluable in collecting data for this study, and Monica Gardner, who read and answered questions on a cited article published in German.We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.Disclosure: None of the authors has any conflict of interest to disclose. NR 59 TC 62 Z9 63 U1 0 U2 7 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD MAY PY 2010 VL 51 IS 5 BP 891 EP 898 DI 10.1111/j.1528-1167.2009.02384.x PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 587OA UT WOS:000277000900023 PM 19845734 ER PT J AU Wassilak, S Orenstein, W AF Wassilak, Steven Orenstein, Walter TI Challenges faced by the global polio eradication initiative SO EXPERT REVIEW OF VACCINES LA English DT Editorial Material ID VACCINE; POLIOVIRUSES C1 [Wassilak, Steven] Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Orenstein, Walter] Bill & Melinda Gates Fdn, Vaccine Delivery, Global Hlth Program, Seattle, WA 98102 USA. RP Wassilak, S (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM swassilak@cdc.gov; walter.orenstein@gatesfoundation.org NR 18 TC 10 Z9 10 U1 1 U2 2 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2010 VL 9 IS 5 BP 447 EP 449 DI 10.1586/ERV.10.45 PG 3 WC Immunology SC Immunology GA 599RT UT WOS:000277931500001 PM 20450316 ER PT J AU de Marco, MDF Alejo, A Hudson, P Damon, IK Alcami, A AF del Mar Fernandez de Marco, Maria Alejo, Ali Hudson, Paul Damon, Inger K. Alcami, Antonio TI The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon SO FASEB JOURNAL LA English DT Article DE immune modulation; cytokine; infection; smallpox; vaccine ID VACCINIA VIRUS; IMMUNE EVASION; ALPHA/BETA INTERFERON; POXVIRUS INFECTION; ANTIVIRAL ACTIVITY; HUMAN-COMPLEMENT; III INTERFERONS; BINDING-PROTEIN; HOST RESPONSE; RECEPTOR AB Variola virus (VARV) caused smallpox, one of the most devastating human diseases and the first to be eradicated, but its deliberate release represents a dangerous threat. Virulent orthopoxviruses infecting humans, such as monkeypox virus (MPXV), could fill the niche left by smallpox eradication and the cessation of vaccination. However, immunomodulatory activities and virulence determinants of VARV and MPXV remain largely unexplored. We report the molecular characterization of the VARV- and MPXV-secreted type I interferon-binding proteins, which interact with the cell surface after secretion and prevent type I interferon responses. The proteins expressed in the baculovirus system have been purified, and their interferon-binding properties characterized by surface plasmon resonance. The ability of these proteins to inhibit a broad range of interferons was investigated to identify potential adaptation to the human immune system. Furthermore, we demonstrate by Western blot and activity assays the expression of the type I interferon inhibitor during VARV and MPXV infections. These findings are relevant for the design of new vaccines and therapeutics to smallpox and emergent virulent orthopoxviruses because the type I interferon-binding protein is a major virulence factor in animal models, vaccination with this protein induces protective immunity, and its neutralization prevents disease progression.-Fernandez de Marco, M. M., Alejo, A., Hudson, P., Damon, I. K., Alcami, A. The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon. FASEB J. 24, 1479-1488 (2010). www.fasebj.org C1 [del Mar Fernandez de Marco, Maria; Alcami, Antonio] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain. [Alejo, Ali] Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctr Invest Sanidad Anim, Madrid, Spain. [Hudson, Paul; Damon, Inger K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Alcami, Antonio] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England. RP Alcami, A (reprint author), Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, C Nicolas Cabrera,1 Campus Canto Blanco, E-28049 Madrid, Spain. EM aalcami@cbm.uam.es RI Alcami, Antonio/F-8512-2015; OI Alcami, Antonio/0000-0002-3333-6016; Alejo, Ali/0000-0002-1613-6063 FU Wellcome Trust; European Union; Spanish Ministry of Science and Innovation FX The authors thank R. Martin for excellent technical assistance and Sylvia Gutierrez Erlandsson for help with microscopy. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. This work was funded by the Wellcome Trust and the European Union. A. Alejo was supported by a Ramon y Cajal contract (Spanish Ministry of Science and Innovation). This article is dedicated to the memory of Riccardo Wittek. NR 45 TC 5 Z9 5 U1 0 U2 8 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAY PY 2010 VL 24 IS 5 BP 1479 EP 1488 DI 10.1096/fj.09-144733 PG 10 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 589OD UT WOS:000277158900020 ER PT J AU Simonetti, J Bulkow, L McMahon, BJ Homan, C Snowball, M Negus, S Williams, J Livingston, SE AF Simonetti, Josephine Bulkow, Lisa McMahon, Brian J. Homan, Chriss Snowball, Mary Negus, Susan Williams, James Livingston, Stephen E. TI Clearance of Hepatitis B Surface Antigen and Risk of Hepatocellular Carcinoma in a Cohort Chronically Infected with Hepatitis B Virus SO HEPATOLOGY LA English DT Article ID HBSAG SEROCLEARANCE; CLINICAL-OUTCOMES; DELAYED CLEARANCE; CHRONIC CARRIERS; HBV INFECTION; SERUM HBSAG; GENOTYPE-B; PROGNOSIS; MANAGEMENT; RECOVERY AB Some individuals who are chronically infected with hepatitis B virus (HBV) eventually lose hepatitis B surface antigen (HBsAg). Hepatocellular carcinoma (HCC) has been demonstrated to occur in a few patients after loss of HBsAg. Neither factors associated with loss of HBsAg nor the incidence of HCC thereafter have been clearly elucidated. We performed a prospective population-based cohort study in 1,271 Alaska Native persons with chronic HBV infection followed for an average of 19.6 years to determine factors associated with loss of HBsAg and risk of developing HCC thereafter. HBsAg loss occurred in 158 persons for a rate of HBsAg clearance of 0.7%/year. Older age, but not sex, was associated with clearance of HBsAg, and loss of HBsAg was not associated with any particular HBV genotypes (A, B, C, D, and F) found in this population. Participants were followed for an average of 108.9 months after HBsAg loss. Six patients, two with cirrhosis and four without, developed HCC a mean of 7.3 years after HBsAg clearance (range, 2.0-15.5 years). The incidence of HCC after clearance of HBsAg was 36.8 per 100,000 per year (95% CI 13.5-80.0) which was significantly lower than the rate in those who remained HBsAg-positive (195.7 cases per 100,000 person-years of follow-up [95% CI 141.1-264.5; P < 0.001]). After loss of HBsAg, HBV DNA was detected in the sera of 28 (18%) of those who cleared a median of 3.6 years after clearance. Conclusion: HCC can occur in persons with chronic hepatitis B who have lost HBsAg, even in the absence of cirrhosis. These persons should still be followed with periodic liver ultrasound to detect HCC early. (HEPATOLOGY 2010;51:1531-1537.) C1 [Simonetti, Josephine; McMahon, Brian J.; Homan, Chriss; Snowball, Mary; Negus, Susan; Williams, James; Livingston, Stephen E.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK 99508 USA. [Bulkow, Lisa; McMahon, Brian J.] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA. RP McMahon, BJ (reprint author), Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, 4315 Diplomacy Dr, Anchorage, AK 99508 USA. EM bdm9@cdc.gov FU Alaska Native Tribal Health Consortium, Anchorage; Native American Research Centers for Health [U26 94 00005] FX Supported by Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, and Native American Research Centers for Health (grant U26 94 00005). NR 29 TC 95 Z9 101 U1 1 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD MAY PY 2010 VL 51 IS 5 BP 1531 EP 1537 DI 10.1002/hep.23464 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 590XJ UT WOS:000277261400010 PM 20087968 ER PT J AU Jiang, BM Patel, M Parashar, U AF Jiang, Baoming Patel, Manish Parashar, Umesh TI Rotavirus vaccines for global use What are the remaining issues and challenges? SO HUMAN VACCINES LA English DT Editorial Material DE rotavirus; Rotarix (TM); RotaTeq (R); intussusception; IRV ID INTUSSUSCEPTION; EFFICACY; CHILDREN; INFANTS; SAFETY C1 [Jiang, Baoming; Patel, Manish; Parashar, Umesh] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Jiang, BM (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. EM bxj4@cdc.gov NR 20 TC 2 Z9 2 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD MAY PY 2010 VL 6 IS 5 BP 425 EP 427 PG 3 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 652GW UT WOS:000281992700016 PM 20534979 ER PT J AU Crews, DC Plantinga, LC Miller, ER Saran, R Hedgetnan, E Saydah, SH Williams, DE Powe, NR AF Crews, Deidra C. Plantinga, Laura C. Miller, Edgar R., III Saran, Rajiv Hedgetnan, Elizabeth Saydah, Sharon H. Williams, Desmond E. Powe, Neil R. CA Ctr Dis Control Prevention TI Prevalence of Chronic Kidney Disease in Persons With Undiagnosed or Prehypertension in the United States SO HYPERTENSION LA English DT Article DE epidemiology; albuminuria; renal; prevention; awareness; surveillance ID STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; BLOOD-PRESSURE; SERUM CREATININE; US ADULTS; AWARENESS; TRENDS; RISK; HYPERTENSION; EQUATION AB Htypertension is both a cause and a consequence of chronic kidney disease, but the prevalence of chronic kidney disease throughout the diagnostic spectrum of blood pressure has not been established. We determined the prevalence of chronic kidney disease within blood pressure categories in 17 794 adults surveyed by the National Health and Nutrition Examination Survey during 1999-2006, Diagnosed hypertension was defined as self-reported provider diagnosis (n=5832); undiagnosed hypertension was defined as systolic blood pressure >= 1.40 mm Jig or diastolic blood pressure >= 90 mm fig, without report of provider diagnosis (n=3046); prehypertension was defined as systolic blood pressure >= 120 and <140 mm fig or diastolic blood pressure >= 80 and <90 mm fig (n=3719); and normal was defined as systolic blood pressure <120 mm Hg and diastolic blood pressure <80 ram fig (n=5197). Chronic kidney disease was defined as estimated glomerular filtration rate <60 mL/min per 1,73 m(2) or urinary albuunin:creatinine ratio >30 mg/g, Prevalences of chronic kidney disease among those with prehypertension and undiagnosed hypertension were 17.3% and 22.0%, respectively, compared with 27.5% with diagnosed hypertension and 13.4% with normal blood pressure, after adjustment for age, sex, and race in multivariable logistic regression. This pattern persisted with varying definitions of kidney disease; macroalbuminuria (urinary albumin:creatininc ratio >300 mg/g) had the strongest association with increasing blood pressure category (odds ratio: 2,37 [95% CI: 2,00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease. (Hypertension. 2010;55:1102-1109.) C1 [Crews, Deidra C.] Johns Hopkins Univ, Dept Med, Div Nephrol, Baltimore, MD 21224 USA. [Miller, Edgar R., III] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD 21224 USA. [Plantinga, Laura C.; Powe, Neil R.] San Francisco Gen Hosp, Dept Med, San Francisco, CA 94110 USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. [Saran, Rajiv; Hedgetnan, Elizabeth] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA. [Saran, Rajiv; Hedgetnan, Elizabeth] Univ Michigan, Kidney Epidemiol & Cost Ctr, Ann Arbor, MI 48109 USA. [Saydah, Sharon H.; Williams, Desmond E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Crews, DC (reprint author), Johns Hopkins Univ, Dept Med, Div Nephrol, 4940 Eastern Ave,B Bldg,2nd Floor, Baltimore, MD 21224 USA. EM dcrews1@jhmi.edu FU Centers for Disease Control and Prevention through the Association of American Medical College [U36/CCU319276]; Association of American Medical Colleges [MM-0997-07/07, MM-1143-10/10]; Robert Wood Johnson Foundation; National Institute of Diabetes, Digestive and Kidney Disease [K24DK02643] FX This project was supported under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of American Medical Colleges, grant U36/CCU319276, Association of American Medical Colleges identification numbers MM-0997-07/07 and MM-1143-10/10. D.C.C. is supported by the Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation. N.R.P. is partially supported by the National Institute of Diabetes, Digestive and Kidney Disease grant K24DK02643. NR 22 TC 63 Z9 67 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X J9 HYPERTENSION JI Hypertension PD MAY PY 2010 VL 55 IS 5 BP 1102 EP U60 DI 10.1161/HYPERTENSIONAHA.110.150722 PG 10 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 583KA UT WOS:000276672500010 PM 20308607 ER PT J AU Cohen, SH Gerding, DN Johnson, S Kelly, CP Loo, VG McDonald, LC Pepin, J Wilcox, MH AF Cohen, Stuart H. Gerding, Dale N. Johnson, Stuart Kelly, Ciaran P. Loo, Vivian G. McDonald, L. Clifford Pepin, Jacques Wilcox, Mark H. TI Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ANTIBIOTIC-ASSOCIATED DIARRHEA; TANDEM-REPEAT ANALYSIS; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; PROTON PUMP INHIBITORS; RISK-FACTORS; HOSPITALIZED-PATIENTS; TOXIN-A; PSEUDOMEMBRANOUS COLITIS; INTRAVENOUS IMMUNOGLOBULIN AB Since publication of the Society for Healthcare Epidemiology of America position paper on Clostridium difficile infection in 1995, significant changes have occurred in the epidemiology and treatment of this infection. C. difficile remains the most important cause of healthcare-associated diarrhea and is increasingly important as a community pathogen. A more virulent strain of C. difficile has been identified and has been responsible for more-severe cases of disease worldwide. Data reporting the decreased effectiveness of metronidazole in the treatment of severe disease have been published. Despite the increasing quantity of data available, areas of controversy still exist. This guideline updates recommendations regarding epidemiology, diagnosis, treatment, and infection control and environmental management. Infect Control Hosp Epidemiol 2010; 31(5):431-455 C1 [Cohen, Stuart H.] Univ Calif Davis, Med Ctr, Dept Internal Med, Div Infect & Immunol Dis, Sacramento, CA 95817 USA. [Gerding, Dale N.; Johnson, Stuart] Loyola Univ Chicago Stritch Sch Med, Res Serv, Vet Affairs Edward Hines Jr Hosp, Maywood, IL USA. [Gerding, Dale N.; Johnson, Stuart] Loyola Univ Chicago Stritch Sch Med, Div Infect Dis, Dept Med, Maywood, IL USA. [Kelly, Ciaran P.] Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02215 USA. [Loo, Vivian G.] McGill Univ, Dept Microbiol, Ctr Hlth, Montreal, PQ H3A 2T5, Canada. [McDonald, L. Clifford] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. [Pepin, Jacques] Univ Sherbrooke, Dept Microbiol & Infect Dis, Quebec City, PQ, Canada. [Wilcox, Mark H.] Univ Leeds, Dept Microbiol, Leeds Teaching Hosp Natl Hlth Serv Trust, Leeds LS2 9JT, W Yorkshire, England. [Wilcox, Mark H.] Univ Leeds, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England. RP Cohen, SH (reprint author), Dis Soc Amer, Clin Affairs, 1300 Wilson Blvd,Suite 300, Arlington, VA 22209 USA. EM idsaguidelines@idsociety.org NR 233 TC 1291 Z9 1340 U1 21 U2 106 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 431 EP 455 DI 10.1086/651706 PG 25 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200001 PM 20307191 ER PT J AU Schaefer, MK Ellingson, K Conover, C Genisca, AE Currie, D Esposito, T Panttila, L Ruestow, P Martin, K Cronin, D Costello, M Sokalski, S Fridkin, S Srinivasan, A AF Schaefer, Melissa K. Ellingson, Katherine Conover, Craig Genisca, Alicia E. Currie, Donna Esposito, Tina Panttila, Laura Ruestow, Peter Martin, Karen Cronin, Diane Costello, Michael Sokalski, Stephen Fridkin, Scott Srinivasan, Arjun TI Evaluation of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Reporting Methicillin-Resistant Staphylococcus aureus Infections at a Hospital in Illinois SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID CARE-ASSOCIATED INFECTIONS AB BACKGROUND. States, including Illinois, have passed legislation mandating the use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for reporting healthcare-associated infections, such as methicillin-resistant Staphylococcus aureus (MRSA). OBJECTIVE. To evaluate the sensitivity of ICD-9-CM code combinations for detection of MRSA infection and to understand implications for reporting. METHODS. We reviewed discharge and microbiology databases from July through August of 2005, 2006, and 2007 for ICD-9-CM codes or microbiology results suggesting MRSA infection at a tertiary care hospital near Chicago, Illinois. Medical records were reviewed to confirm MRSA infection. Time from admission to first positive MRSA culture result was evaluated to identify hospital-onset MRSA (HO-MRSA) infections. The sensitivity of MRSA code combinations for detecting confirmed MRSA infections was calculated using all codes present in the discharge record ( up to 15); the effect of reviewing only 9 diagnosis codes, the number reported to the Centers for Medicare and Medicaid Services, was also evaluated. The sensitivity of the combination of diagnosis codes for detection of HO-MRSA infections was compared with that for community-onset MRSA (CO-MRSA) infections. RESULTS. We identified 571 potential MRSA infections with the use of screening criteria; 403 (71%) were confirmed MRSA infections, of which 61 (15%) were classified as HO-MRSA. The sensitivity of MRSA code combinations was 59% for all confirmed MRSA infections when 15 diagnoses were reviewed compared with 31% if only 9 diagnoses were reviewed (P < .001). The sensitivity of code combinations was 33% for HO-MRSA infections compared with 62% for CO-MRSA infections (P < .001). CONCLUSIONS. Limiting analysis to 9 diagnosis codes resulted in low sensitivity. Furthermore, code combinations were better at revealing CO-MRSA infections than HO-MRSA infections. These limitations could compromise the validity of ICD-9-CM codes for interfacility comparisons and for reporting of healthcare-associated MRSA infections. Infect Control Hosp Epidemiol 2010; 31(5):463-468 C1 [Schaefer, Melissa K.; Ellingson, Katherine; Genisca, Alicia E.; Fridkin, Scott; Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Schaefer, Melissa K.; Ellingson, Katherine] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Conover, Craig] Illinois Dept Publ Hlth, Springfield, IL 62761 USA. [Currie, Donna; Esposito, Tina; Panttila, Laura; Ruestow, Peter; Martin, Karen; Cronin, Diane; Costello, Michael; Sokalski, Stephen] Advocate Hlth Care, Oak Brook, IL USA. RP Schaefer, MK (reprint author), 1600 Clifton Rd NE,Mailstop A-31, Atlanta, GA 30333 USA. EM mschaefer@cdc.gov NR 17 TC 15 Z9 15 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 463 EP 468 DI 10.1086/651665 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200003 PM 20353360 ER PT J AU Gregory, CJ Llata, E Stine, N Gould, C Santiago, LM Vazquez, GJ Robledo, IE Srinivasan, A Goering, RV Tomashek, KM AF Gregory, Christopher J. Llata, Eloisa Stine, Nicholas Gould, Carolyn Santiago, Luis Manuel Vazquez, Guillermo J. Robledo, Iraida E. Srinivasan, Arjun Goering, Richard V. Tomashek, Kay M. TI Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in Puerto Rico Associated with a Novel Carbapenemase Variant SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID SPINAL-CORD-INJURY; BETA-LACTAMASE; RISK-FACTORS; PSEUDOMONAS-AERUGINOSA; HOSPITALIZED-PATIENTS; NEW-YORK; INFECTIONS; BACTEREMIA; ENTEROBACTERIACEAE; ACQUISITION AB BACKGROUND. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is resistant to almost all antimicrobial agents, and CRKP infections are associated with substantial morbidity and mortality. OBJECTIVE. To describe an outbreak of CRKP in Puerto Rico, determine risk factors for CRKP acquisition, and detail the successful measures taken to control the outbreak. DESIGN. Two case-control studies. SETTING. A 328-bed tertiary care teaching hospital. PATIENTS. Twenty-six CRKP case patients identified during the outbreak period of February through September 2008, 26 randomly selected uninfected control patients, and 26 randomly selected control patients with carbapenem-susceptible K. pneumoniae (CSKP) hospitalized during the same period. METHODS. We performed active case finding, including retrospective review of the hospital's microbiology database and prospective perirectal surveillance culture sampling in high-risk units. Case patients were compared with each control group while controlling for time at risk. We sequenced the bla(KPC) gene with polymerase chain reaction for 7 outbreak isolates and subtyped these isolates with pulsed-field gel electrophoresis. RESULTS. In matched, multivariable analysis, the presence of wounds (hazard ratio, 19.0 [95% confidence interval {CI}, 2.5-142.0]) was associated with CRKP compared with no K. pneumoniae. Transfer between units (adjusted odds ratio [OR], 7.5 [95% CI, 1.8-31.1]), surgery (adjusted OR, 4.0 [95% CI, 1.0-15.7]), and wounds (adjusted OR, 4.9 [95% CI, 1.1-21.8]) were independent risk factors for CRKP compared to CSKP. A novel K. pneumoniae carbapenemase variant (KPC-8) was present in 5 isolates. Implementation of active surveillance for CRKP colonization and cohorting of CRKP patients rapidly controlled the outbreak. CONCLUSIONS. Enhanced surveillance for CRKP colonization and intensified infection control measures that include limiting the physical distribution of patients can reduce CRKP transmission during an outbreak. C1 [Gregory, Christopher J.; Santiago, Luis Manuel; Tomashek, Kay M.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. [Vazquez, Guillermo J.; Robledo, Iraida E.] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA. [Stine, Nicholas] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Goering, Richard V.] Creighton Univ, Sch Med, Omaha, NE USA. [Gregory, Christopher J.; Llata, Eloisa] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Llata, Eloisa; Gould, Carolyn; Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Hlth Care Qual Promot, Atlanta, GA USA. RP Gregory, CJ (reprint author), Ctr Dis Control & Prevent, Dengue Branch, 1324 Calle Canada, San Juan, PR 00920 USA. EM hgk4@cdc.gov OI Goering, Richard/0000-0001-7502-7185 NR 39 TC 58 Z9 63 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 476 EP 484 DI 10.1086/651670 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200005 PM 20334553 ER PT J AU Wiersma, P Schillie, S Keyserling, H Watson, JR De, A Banerjee, SN Drenzek, CL Arnold, KE Shivers, C Kendrick, L Ryan, LG Jensen, B Noble-Wang, J Srinivasan, A AF Wiersma, Petra Schillie, Sarah Keyserling, Harry Watson, J. Renee De, Anindya Banerjee, Shailendra N. Drenzek, Cherie L. Arnold, Kathryn E. Shivers, Christina Kendrick, Lea Ryan, Lydia Gonzalez Jensen, Bette Noble-Wang, Judith Srinivasan, Arjun TI Catheter-Related Polymicrobial Bloodstream Infections among Pediatric Bone Marrow Transplant Outpatients-Atlanta, Georgia, 2007 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID OUTBREAK AB OBJECTIVE. To identify risk factors for polymicrobial bloodstream infections (BSIs) in pediatric bone marrow transplant (BMT) outpatients attending a newly constructed clinic affiliated with a children's hospital. METHODS. All 30 outpatients treated at a new BMT clinic during September 10-21, 2007, were enrolled in a cohort study. The investigation included interviews, medical records review, observations, and bacterial culture and molecular typing of patient and environmental isolates. Data were analyzed using exact conditional logistic regression. RESULTS. Thirteen patients experienced BSIs caused by 16 different, predominantly gram-negative organisms. Presence of a tunneled catheter ( odds ratio [ OR], 19.9 [95% confidence interval {CI}, 2.4-infinity), catheter access ( OR, 13.7 [ 95% CI, 1.8-infinity]), and flushing of a catheter with predrawn saline ( OR, 12.9 [ 95% CI, 1.0-766.0]) were independently associated with BSI. The odds of experiencing a BSI increased by a factor of 16.8 with each additional injection of predrawn saline ( 95% CI, 1.8-827.0). Although no environmental source of pathogens was identified, interviews revealed breaches in recommended infection prevention practice and medication handling. Saline flush solutions were predrawn, and multiple doses were obtained from single-dose preservative-free vials to avoid delays in patient care. CONCLUSION. We speculate that infection prevention challenges in the new clinic, combined with successive needle punctures of vials, facilitated extrinsic contamination and transmission of healthcare-associated pathogens. We recommend that preservative-free single-use vials not be punctured more than once. Use of single-use prefilled saline syringes might prevent multiuse of single-use saline vials. Storage of saline outside a medication supply system might be advisable. Before opening new clinic facilities, hospitals should consider conducting a mock patient flow exercise to identify infection control challenges. Infect Control Hosp Epidemiol 2010; 31(5):522-527 C1 [Wiersma, Petra; Schillie, Sarah] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Shivers, Christina] Ctr Dis Control & Prevent, Epidemiol Elect Program, Atlanta, GA USA. [De, Anindya; Banerjee, Shailendra N.; Noble-Wang, Judith; Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Keyserling, Harry] Emory Univ, Sch Med, Atlanta, GA USA. [Watson, J. Renee; Kendrick, Lea] Childrens Healthcare Atlanta, Atlanta, GA USA. [Wiersma, Petra; Drenzek, Cherie L.; Arnold, Kathryn E.] Georgia Dept Human Resources, Div Publ Hlth, Atlanta, GA USA. RP Wiersma, P (reprint author), 5120 Geneva Pl, Dulles, VA 20189 USA. EM petra.wiersma@gmail.com NR 13 TC 9 Z9 9 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 522 EP 527 DI 10.1086/651668 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200012 PM 20350149 ER PT J AU Kallen, AJ Hidron, AI Patel, J Srinivasan, A AF Kallen, Alexander J. Hidron, Alicia I. Patel, Jean Srinivasan, Arjun TI Multidrug Resistance among Gram-Negative Pathogens That Caused Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2006-2008 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ACINETOBACTER-BAUMANNII; CARBAPENEM-RESISTANT; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; OUTBREAK; SURVEILLANCE AB We evaluated isolates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii that were reported to the National Healthcare Safety Network from January 2006 through December 2008 to determine the proportion that represented multidrug-resistant phenotypes. The pooled mean percentage of resistance varied by the definition used; however, multidrug resistance was relatively common and widespread. Infect Control Hosp Epidemiol 2010; 31(5):528-531 C1 [Kallen, Alexander J.; Hidron, Alicia I.; Patel, Jean; Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. [Hidron, Alicia I.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA. RP Kallen, AJ (reprint author), 1600 Clifton Rd NE,MS A-35, Atlanta, GA 30333 USA. EM AKallen@cdc.gov NR 11 TC 74 Z9 80 U1 0 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 528 EP 531 DI 10.1086/652152 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200013 PM 20334552 ER PT J AU McAllister, L Gaynes, RP Rimland, D McGowan, JE AF McAllister, Laura Gaynes, Robert P. Rimland, David McGowan, John E., Jr. TI Hospitalization Earlier than 1 Year Prior to Admission as an Additional Risk Factor for Methicillin-Resistant Staphylococcus aureus Colonization SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID NASAL CARRIAGE; PREVALENCE; COMMUNITY; INFECTIONS AB Our case-control study sought to identify risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission among patients with no known healthcare-related risk factors. We found that patients whose most recent hospitalization occurred greater than 1 year before their current hospital admission were more likely to have MRSA colonization. In addition, both the time that elapsed since the most recent hospitalization and the duration of that hospitalization affected risk. Infect Control Hosp Epidemiol 2010; 31(5):538-540 C1 [McAllister, Laura; Gaynes, Robert P.] Ctr Dis Control & Prevent, Div Healthcare Qual & Promot, Atlanta, GA 30341 USA. [Gaynes, Robert P.; Rimland, David] Emory Univ, Sch Med, Atlanta, GA USA. [McAllister, Laura; McGowan, John E., Jr.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [Gaynes, Robert P.; Rimland, David] Atlanta Vet Affairs Med Ctr, Decatur, GA USA. RP McAllister, L (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual & Promot, 1600 Clifton Rd,Mailstop A7, Atlanta, GA 30341 USA. EM Gvd5@cdc.gov RI mcgowan jr, john/G-5404-2011 NR 8 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2010 VL 31 IS 5 BP 538 EP 540 DI 10.1086/652451 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 577WR UT WOS:000276255200016 PM 20334507 ER PT J AU Donis, RO Chen, LM Stevens, J AF Donis, R. O. Chen, L. M. Stevens, J. TI Viral characteristics of H5N1 influencing mutation/reassortment events with pandemic potential SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Meeting Abstract C1 [Donis, R. O.; Chen, L. M.; Stevens, J.] Ctr Dis Control & Prevent, Influenza Div, NCIRD, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 SU 1 BP 35 EP 36 PG 2 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 571CS UT WOS:000275729500014 ER PT J AU Belser, JA Tumpey, TM Katz, JM Swayne, DE AF Belser, J. A. Tumpey, T. M. Katz, J. M. Swayne, D. E. TI Possible transmission modes for avian influenza viruses to people: Studies in experimental models SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Meeting Abstract C1 [Belser, J. A.; Tumpey, T. M.; Katz, J. M.] CDC, Immunol & Pathogenesis Branch, Influenza Div, CCID, Atlanta, GA 30333 USA. [Swayne, D. E.] ARS, Exot & Emerging Avian Viral Dis Res Unit, USDA, Athens, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 SU 1 BP 38 EP 38 PG 1 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 571CS UT WOS:000275729500018 ER PT J AU King, L AF King, L. TI Importance of the Human-Animal Interface in the Broader Sense SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Meeting Abstract C1 [King, L.] CDC, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 SU 1 BP 43 EP 43 PG 1 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 571CS UT WOS:000275729500029 ER PT J AU Noriega, LM Verdugo, RJ Araos, R Munita, JM Diaz, V Marcotti, A Perez, J Gonzalez, P Thompson, L Canals, M Hoppe, A Mounts, AW Vial, PA AF Miguel Noriega, Luis Verdugo, Renato J. Araos, Rafael Manuel Munita, Jose Diaz, Violeta Marcotti, Alejandra Perez, Jorge Gonzalez, Patricia Thompson, Luis Canals, Magdalena Hoppe, Arnold Mounts, Anthony W. Vial, Pablo A. TI Pandemic influenza A (H1N1) 2009 with neurological manifestations, a case series SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE H1N1; influenza; neurologic; pandemic; seizure ID VIRUS-INFECTION; ENCEPHALOPATHY; ENCEPHALITIS; CHILDREN; TEXAS AB Objectives Describe a series of atypical presentations of pandemic influenza A (H1N1) 2009. Methods Description of case series using hospital records. Results Six patients aged 1 to 65 years with confirmed pandemic influenza A (H1N1) 2009 infection presented with neurological complications within 2 to 5 days after the first signs of influenza-like illness. All six were admitted with seizures or altered mental status. No abnormalities were found in brain scans or cerebral spinal fluid studies of any of the six. All were discharged without sequelae within days of admission. Conclusions This is only the second report of pandemic influenza presenting with neurological manifestations. Clinicians caring for patients when pandemic influenza is prevalent in their communities should maintain a high level of awareness of the potential atypical presentations with which this disease can appear. C1 [Miguel Noriega, Luis; Verdugo, Renato J.; Araos, Rafael; Manuel Munita, Jose; Diaz, Violeta; Marcotti, Alejandra; Perez, Jorge; Gonzalez, Patricia; Thompson, Luis; Canals, Magdalena; Hoppe, Arnold; Vial, Pablo A.] Univ Desarrollo, Clin Alemana Sch Med, Clin Alemana Santiago, Dept Med, Santiago, Chile. [Mounts, Anthony W.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Mounts, AW (reprint author), WHO, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM mountsa@who.int RI Munita, Jose/G-3601-2016 OI Munita, Jose/0000-0002-7870-1056 NR 13 TC 13 Z9 13 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 IS 3 BP 117 EP 120 DI 10.1111/j.1750-2659.2010.00131.x PG 4 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 579GF UT WOS:000276356100002 PM 20409207 ER PT J AU Reyes, L Arvelo, W Estevez, A Gray, J Moir, JC Gordillo, B Frenkel, G Ardon, F Moscoso, F Olsen, SJ Fry, AM Lindstrom, S Lindblade, KA AF Reyes, Lissette Arvelo, Wences Estevez, Alejandra Gray, Jennifer Moir, Juan C. Gordillo, Betty Frenkel, Gal Ardon, Francisco Moscoso, Fabiola Olsen, Sonja J. Fry, Alicia M. Lindstrom, Steve Lindblade, Kim A. TI Population-based surveillance for 2009 pandemic influenza A (H1N1) virus in Guatemala, 2009 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Epidemiology; Guatemala; influenza; pandemic influenza; population-based ID SEVERE BRONCHIOLITIS; INFECTION; INFANTS; IMPACT AB Background In April 2009, 2009 pandemic influenza A H1N1 (2009 H1N1) was first identified in Mexico but did not cause widespread transmission in neighboring Guatemala until several weeks later. Methodology and principle findings Using a population-based surveillance system for hospitalized pneumonia and influenza-like illness ongoing before the 2009 H1N1 pandemic began, we tracked the onset of 2009 H1N1 infection in Guatemala. We identified 239 individuals infected with influenza A (2009 H1N1) between May and December 2009, of whom 76 were hospitalized with pneumonia and 11 died (case fatality proportion: 4 center dot 6%, 95% confidence interval [CI] 2 center dot 3-8 center dot 1%). The median age of patients infected with 2009 H1N1 was 8 center dot 8 years, the median age of those hospitalized with pneumonia was 4 center dot 2 years, and five (45 center dot 5%) deaths occurred in children < 5 years old. Crude rates of hospitalization between May and December 2009 were highest for children < 5 years old. Twenty-one (27 center dot 6%) of the patients hospitalized with 2009 H1N1 were admitted to the intensive care unit and eight (10 center dot 5%) required mechanical ventilation. Underlying chronic conditions were noted in 14 (18 center dot 4%) of patients with pneumonia hospitalized with 2009 H1N1 infection. Conclusions and significance Chronic illnesses may be underdiagnosed in Guatemala, making it difficult to identify this risk group for vaccination. Children 6 months to 5 years old should be among priority groups for vaccination to prevent serious consequences because of 2009 H1N1 infection. C1 [Arvelo, Wences; Lindblade, Kim A.] Ctr Dis Control & Prevent, Int Emerging Infect Program, Reg Off Cent Amer & Panama, Guatemala City, Guatemala. [Reyes, Lissette; Moir, Juan C.; Gordillo, Betty; Ardon, Francisco] Minist Salud Publ & Asistencia Social, Guatemala City, Guatemala. [Estevez, Alejandra; Gray, Jennifer; Frenkel, Gal; Moscoso, Fabiola; Lindblade, Kim A.] Univ Valle Guatemala, Ctr Estudios Salud, Guatemala City, Guatemala. [Olsen, Sonja J.; Fry, Alicia M.; Lindstrom, Steve] Ctr Dis Control & Prevent, Div Influenza, Atlanta, GA USA. RP Lindblade, KA (reprint author), Ctr Dis Control & Prevent, Int Emerging Infect Program, Reg Off Cent Amer & Panama, Guatemala City, Guatemala. EM kil2@cdc.gov FU CDC's Global Disease Detection, Emerging Infections and influenza appropriations FX Funding for these activities was provided by the CDC's Global Disease Detection, Emerging Infections and influenza appropriations. The CDC participated in all aspects of study design, data collection, data analysis and manuscript preparation. NR 14 TC 18 Z9 19 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 IS 3 BP 129 EP 140 DI 10.1111/j.1750-2659.2010.00138.x PG 12 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 579GF UT WOS:000276356100004 PM 20409209 ER PT J AU Haymond, M Anderson, B Bush, C Gunn, S Holden, H Jones, M Hwu, K McGirk, S Mckay, S Thamotharan, S Schreiner, B Zarate, M Cuttler, L Abrams, E Casey, T Dahms, W Drotar, D Huestis, S Ievers-Landis, C McGuigan, P Sundararajan, S Geffner, M Chang, N Dreimane, D Halvorson, M Hernandez, S Kaufman, F Mansilla, V Ortiz, R Ward, A Wexler, K Yasuda, P Katz, LL Berkowitz, R Boyd, S Carchidi, C Johnson, B Kaplan, J Keating, C Kneeshaw-Price, S Lassiter, C Lipman, T Magge, S McGinley, G Schwartzman, B Willi, S Arslanian, S Bacha, F Foster, S Galvin, B Hannon, T Kriska, A Libman, I Marcus, M Porter, K Songer, T Venditti, E Goland, R Cain, R Fennoy, I Gallagher, D Kringas, P Leibel, N Motaghedi, R Ng, D Ovalles, M Pellizzari, M Rapaport, R Robbins, K Seidman, D Siegel-Czarkowski, L Speiser, P Laffel, L Goebel-Fabbri, A Hall, M Higgins, L Malloy, M Milaszewski, K Orkin, L Rodriguez-Ventura, A Nathan, D Bissett, L Blumenthal, K Delahanty, L Goldman, V Goseco, A Larkin, M Levitsky, L McEachern, R Milaszewski, K Norman, D Nwosu, B Park-Bennett, S Richards, D Sherry, N Steiner, B Tollefsen, S Carnes, S Dempsher, D Flomo, D Floreen, A Kociela, V Whelan, T Wolff, B Weinstock, R Bowerman, D Bulger, J Duncan, K Franklin, R Hartsig, J Izquierdo, R Kanaley, J Kearns, J Meyer, S Saletsky, R Trief, P Zeitler, P Abramson, N Bradhurst, A Celona-Jacobs, N Glazner, J Higgins, J Hoe, F Klingensmith, G Nadeau, K Strike, H Witten, T Copeland, K Brown, R Chadwick, J Chalmers, L Macha, C Nordyke, A Poulsen, T Pratt, L Preske, J Schanuel, J Smith, J Sternlof, S Swisher, R Hale, D Amodei, N Barajas, R Cody, C Haffner, S Hernandez, J Ibarra, C Lynch, J Morales, E Rivera, S Rupert, G Wauters, A White, N Arbelaez, A Jones, J Jones, T Sadler, M Tanner, M Timpson, A Welch, R Caprio, S Grey, M Guandalini, C Lavietes, S Mignosa, M Rose, P Syme, A Tamborlane, W Hirst, K Coombs, L Edelstein, S Grover, N Long, C Pyle, L Linder, B Marcovina, S Chmielewski, J Ramirez, M Strylewicz, G Shepherd, J Fan, B Marquez, L Sherman, M Wang, J Mayer-Davis, E Liu, Y Nichols, M Wilfley, D Aldrich-Rasche, D Franklin, K Leibach, G Massmann, C Mills, M O'Brien, D Patterson, J Tibbs, T Van Buren, D Zhang, P Palmert, M Epstein, L Silverstein, J AF Haymond, M. Anderson, B. Bush, C. Gunn, S. Holden, H. Jones, M. Hwu, K. McGirk, S. McKay, S. Thamotharan, S. Schreiner, B. Zarate, M. Cuttler, L. Abrams, E. Casey, T. Dahms, W. Drotar, D. Huestis, S. Ievers-Landis, C. McGuigan, P. Sundararajan, S. Geffner, M. Chang, N. Dreimane, D. Halvorson, M. Hernandez, S. Kaufman, F. Mansilla, V. Ortiz, R. Ward, A. Wexler, K. Yasuda, P. Katz, L. Levitt Berkowitz, R. Boyd, S. Carchidi, C. Johnson, B. Kaplan, J. Keating, C. Kneeshaw-Price, S. Lassiter, C. Lipman, T. Magge, S. McGinley, G. Schwartzman, B. Willi, S. Arslanian, S. Bacha, F. Foster, S. Galvin, B. Hannon, T. Kriska, A. Libman, I. Marcus, M. Porter, K. Songer, T. Venditti, E. Goland, R. Cain, R. Fennoy, I. Gallagher, D. Kringas, P. Leibel, N. Motaghedi, R. Ng, D. Ovalles, M. Pellizzari, M. Rapaport, R. Robbins, K. Seidman, D. Siegel-Czarkowski, L. Speiser, P. Laffel, L. Goebel-Fabbri, A. Hall, M. Higgins, L. Malloy, M. Milaszewski, K. Orkin, L. Rodriguez-Ventura, A. Nathan, D. Bissett, L. Blumenthal, K. Delahanty, L. Goldman, V. Goseco, A. Larkin, M. Levitsky, L. McEachern, R. Milaszewski, K. Norman, D. Nwosu, B. Park-Bennett, S. Richards, D. Sherry, N. Steiner, B. Tollefsen, S. Carnes, S. Dempsher, D. Flomo, D. Floreen, A. Kociela, V. Whelan, T. Wolff, B. Weinstock, R. Bowerman, D. Bulger, J. Duncan, K. Franklin, R. Hartsig, J. Izquierdo, R. Kanaley, J. Kearns, J. Meyer, S. Saletsky, R. Trief, P. Zeitler, P. Abramson, N. Bradhurst, A. Celona-Jacobs, N. Glazner, J. Higgins, J. Hoe, F. Klingensmith, G. Nadeau, K. Strike, H. Witten, T. Copeland, K. Brown, R. Chadwick, J. Chalmers, L. Macha, C. Nordyke, A. Poulsen, T. Pratt, L. Preske, J. Schanuel, J. Smith, J. Sternlof, S. Swisher, R. Hale, D. Amodei, N. Barajas, R. Cody, C. Haffner, S. Hernandez, J. Ibarra, C. Lynch, J. Morales, E. Rivera, S. Rupert, G. Wauters, A. White, N. Arbelaez, A. Jones, J. Jones, T. Sadler, M. Tanner, M. Timpson, A. Welch, R. Caprio, S. Grey, M. Guandalini, C. Lavietes, S. Mignosa, M. Rose, P. Syme, A. Tamborlane, W. Hirst, K. Coombs, L. Edelstein, S. Grover, N. Long, C. Pyle, L. Linder, B. Marcovina, S. Chmielewski, J. Ramirez, M. Strylewicz, G. Shepherd, J. Fan, B. Marquez, L. Sherman, M. Wang, J. Mayer-Davis, E. Liu, Y. Nichols, M. Wilfley, D. Aldrich-Rasche, D. Franklin, K. Leibach, G. Massmann, C. Mills, M. O'Brien, D. Patterson, J. Tibbs, T. Van Buren, D. Zhang, P. Palmert, M. Epstein, L. Silverstein, J. CA TODAY Study Grp TI Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study (vol 34, pg 946, 2010) SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Correction C1 [Haymond, M.; Anderson, B.; Bush, C.; Gunn, S.; Holden, H.; Jones, M.; Hwu, K.; McGirk, S.; McKay, S.; Thamotharan, S.; Schreiner, B.; Zarate, M.] Baylor Coll Med, Houston, TX 77030 USA. [Cuttler, L.; Abrams, E.; Casey, T.; Dahms, W.; Drotar, D.; Huestis, S.; Ievers-Landis, C.; McGuigan, P.; Sundararajan, S.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Geffner, M.; Chang, N.; Dreimane, D.; Halvorson, M.; Hernandez, S.; Kaufman, F.; Mansilla, V.; Ortiz, R.; Ward, A.; Wexler, K.; Yasuda, P.] Childrens Hosp Los Angeles, Los Angeles, CA USA. [Katz, L. Levitt; Berkowitz, R.; Boyd, S.; Carchidi, C.; Johnson, B.; Kaplan, J.; Keating, C.; Kneeshaw-Price, S.; Lassiter, C.; Lipman, T.; Magge, S.; McGinley, G.; Schwartzman, B.; Willi, S.] Childrens Hosp Philadelphia, Philadelphia, PA USA. [Arslanian, S.; Bacha, F.; Foster, S.; Galvin, B.; Hannon, T.; Kriska, A.; Libman, I.; Marcus, M.; Porter, K.; Songer, T.; Venditti, E.] Childrens Hosp Pittsburgh, Pittsburgh, PA USA. [Goland, R.; Cain, R.; Fennoy, I.; Gallagher, D.; Kringas, P.; Leibel, N.; Motaghedi, R.; Ng, D.; Ovalles, M.; Pellizzari, M.; Rapaport, R.; Robbins, K.; Seidman, D.; Siegel-Czarkowski, L.; Speiser, P.] Columbia Univ, Med Ctr, New York, NY 10027 USA. [Milaszewski, K.; Nathan, D.; Bissett, L.; Blumenthal, K.; Delahanty, L.; Goldman, V.; Goseco, A.; Larkin, M.; Levitsky, L.; McEachern, R.; Norman, D.; Nwosu, B.; Park-Bennett, S.; Richards, D.; Sherry, N.; Steiner, B.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Tollefsen, S.; Carnes, S.; Dempsher, D.; Flomo, D.; Floreen, A.; Kociela, V.; Whelan, T.; Wolff, B.] St Louis Univ, St Louis, MO 63103 USA. [Weinstock, R.; Bowerman, D.; Bulger, J.; Duncan, K.; Franklin, R.; Hartsig, J.; Izquierdo, R.; Kanaley, J.; Kearns, J.; Meyer, S.; Saletsky, R.; Trief, P.] SUNY Upstate Med Univ, Syracuse, NY USA. [Zeitler, P.; Celona-Jacobs, N.; Glazner, J.; Higgins, J.; Hoe, F.; Klingensmith, G.; Nadeau, K.; Strike, H.; Witten, T.] Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA. [Copeland, K.; Brown, R.; Chadwick, J.; Chalmers, L.; Macha, C.; Nordyke, A.; Poulsen, T.; Pratt, L.; Preske, J.; Schanuel, J.; Smith, J.; Sternlof, S.; Swisher, R.] Univ Oklahoma, Hlth Sci Ctr, Norman, OK 73019 USA. [Hale, D.; Amodei, N.; Barajas, R.; Cody, C.; Haffner, S.; Hernandez, J.; Ibarra, C.; Lynch, J.; Morales, E.; Rivera, S.; Rupert, G.; Wauters, A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [White, N.; Arbelaez, A.; Jones, J.; Jones, T.; Sadler, M.; Tanner, M.; Timpson, A.; Welch, R.] Washington Univ, Sch Med, St Louis, MO 63130 USA. [Caprio, S.; Grey, M.; Guandalini, C.; Lavietes, S.; Mignosa, M.; Rose, P.; Syme, A.; Tamborlane, W.] Yale Univ, New Haven, CT 06520 USA. [Hirst, K.; Coombs, L.; Edelstein, S.; Grover, N.; Long, C.; Pyle, L.] George Washington Univ, Ctr Biostat, Washington, DC 20052 USA. [Linder, B.] NIDDK, Bethesda, MD 20892 USA. [Marcovina, S.; Chmielewski, J.; Ramirez, M.; Strylewicz, G.] Washington Univ, NW Lipid Res Labs, Cent Blood Lab, St Louis, MO 63130 USA. [Shepherd, J.; Fan, B.; Marquez, L.; Sherman, M.; Wang, J.] Univ Calif San Francisco, DEXA Reading Ctr, San Francisco, CA 94143 USA. [Mayer-Davis, E.; Liu, Y.; Nichols, M.] Univ S Carolina, Diet Assessment Ctr, Columbia, SC 29208 USA. [Wilfley, D.; Aldrich-Rasche, D.; Franklin, K.; Leibach, G.; Massmann, C.; Mills, M.; O'Brien, D.; Patterson, J.; Tibbs, T.; Van Buren, D.] Washington Univ, Lifestyle Program Core, St Louis, MO 63130 USA. [Palmert, M.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Epstein, L.] SUNY Buffalo, Buffalo, NY 14260 USA. [Silverstein, J.] Univ Florida, Gainesville, FL 32611 USA. [Zhang, P.] CDC, Atlanta, GA 30333 USA. RP Haymond, M (reprint author), Baylor Coll Med, Houston, TX 77030 USA. NR 1 TC 1 Z9 1 U1 1 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD MAY PY 2010 VL 34 IS 5 BP 946 EP 946 DI 10.1038/ijo.2009.247 PG 1 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 593EP UT WOS:000277435700020 ER PT J AU Mosimaneotsile, B Mathoma, A Chengeta, B Nyirenda, S Agizew, TB Tedla, Z Motsamai, OI Kilmarx, PH Wells, CD Samandari, T AF Mosimaneotsile, Barudi Mathoma, Anikie Chengeta, Bafanana Nyirenda, Samba Agizew, Tefera B. Tedla, Zegabriel Motsamai, Oaitse I. Kilmarx, Peter H. Wells, Charles D. Samandari, Taraz TI Isoniazid Tuberculosis Preventive Therapy in HIV-Infected Adults Accessing Antiretroviral Therapy: A Botswana Experience, 2004-2006 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE tuberculosis; preventive therapy; HIV infections; isoniazid; mass screening; adherence ID HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1-INFECTED ADULTS; CONTROLLED-TRIAL; UGANDAN ADULTS; SOUTH-AFRICA; COHORT; RISK; HEPATOTOXICITY; HEPATITIS; PROGRAM AB Objectives: To describe reasons for exclusion from isoniazid tuberculosis preventive therapy (IPT) and outcomes of persons living with HIV (PLWH) during 6 months of IPT. Methods: In a clinical trial conducted in government clinics, first screening (screen 1) used National IPT Program guidelines and a second screening (screen 2) was trial specific. Adherence was defined as attending 6 monthly visits. Results: Between 2004 and 2006, at 4018 screening visits, 2934 (73%) PLWH met screen 1 criteria; 1995 (68%) met screen 2 criteria and were enrolled. Major reasons for exclusion were illness (66%) at screen 1 and abnormal chest radiographs (36%) at screen 2. Tuberculin skin tests were >= 5 mm in 24% of those enrolled and 31% had CD4 lymphocyte counts <200 cells/mm(3). During the 6 months, 8 (0.40%) developed tuberculosis disease, 28 (1.4%) had severe adverse events (19/28 were hepatitis including one death probably isoniazid-associated), 20 others died, and 22% initiated antiretroviral therapy (ART). Although adherence was 86%, being on ART improved adherence: relative risk 1.41 (95% confidence limits 1.04-1.91). In multivariate analysis, ART was associated with a 4.38 greater odds of adherence to IPT. Conclusions: Six months of IPT was relatively safe and well-tolerated by PLWH. Adherence to IPT was significantly better among those receiving ART with IPT. C1 [Mosimaneotsile, Barudi; Mathoma, Anikie; Chengeta, Bafanana; Nyirenda, Samba; Agizew, Tefera B.; Tedla, Zegabriel; Samandari, Taraz] BOTUSA, Gaborone, Botswana. [Motsamai, Oaitse I.] Minist Hlth, Natl TB Programme, Gaborone, Botswana. [Kilmarx, Peter H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Wells, Charles D.; Samandari, Taraz] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Mosimaneotsile, Barudi; Mathoma, Anikie; Chengeta, Bafanana; Nyirenda, Samba; Agizew, Tefera B.; Tedla, Zegabriel; Samandari, Taraz] BOTUSA, Francistown, Botswana. RP Samandari, T (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, 6100 Clifton Rd NE,MS E-10, Atlanta, GA 30333 USA. EM tts0@cdc.gov OI Kilmarx, Peter/0000-0001-6464-3345 FU Data and Safety Monitoring Board FX The authors thank the study participants, the data entry team, and the hard work of the research nurses who carried out the day-to-day work of the IPT Trial. The study would not have been possible without the generous cooperation of Ministry of Health and Ministry of Local Government health workers. We acknowledge the guidance and support of the members of the Data and Safety Monitoring Board: Drs. Jonathan Levin, Ndwapi Ndwapi, Andrew Nunn (Chair), and Karin Weyer, and greatly value the key role of the Trial's Endpoints Committee: Drs. John L. Johnson, Marape Marape, Abraham Miranda (Chair), and Helmuth Reuter. The coauthors appreciate the contributions of Drs. Elizabeth Talbot, Themba Moeti and Howard Moffat to the original conception and design of the protocol. NR 36 TC 24 Z9 25 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2010 VL 54 IS 1 BP 71 EP 77 DI 10.1097/QAI.0b013e3181c3cbf0 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 587OG UT WOS:000277001500010 PM 19934764 ER PT J AU Begier, EM Bennani, Y Forgione, L Punsalang, A Hanna, DB Herrera, J Torian, L Gbur, M Sepkowitz, KA Parvez, F AF Begier, Elizabeth M. Bennani, Yussef Forgione, Lisa Punsalang, Amado Hanna, David B. Herrera, Jeffrey Torian, Lucia Gbur, Maria Sepkowitz, Kent A. Parvez, Farah TI Undiagnosed HIV Infection Among New York City Jail Entrants, 2006: Results of a Blinded Serosurvey SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV infections/diagnosis; HIV infections/epidemiology; prevalence; prisons; prisoners ID UNITED-STATES; POPULATION; PREVENTION; PREVALENCE; RISK AB Objective: Since 2004, when all New York City jail entrants began being offered rapid testing at medical intake, HIV testing has increased 4-fold. To guide further service improvement, we determined HIV prevalence among jail entrants, including proportion undiagnosed. Methods: Remnant serum from routine syphilis screening was salvaged for blinded HIV testing in 2006. Using HIV surveillance data and electronic clinical data, we ascertained previously diagnosed HIV infections before permanently removing identifiers. We defined "undiagnosed" as HIV-infected entrants who were unreported to surveillance and denied HIV infection. Results: Among the 6411 jail entrants tested (68.9% of admissions), HIV prevalence was 5.2% overall (males 4.7%; females: 9.8%). Adjusting for those not in the serosurvey, estimated seroprevalence is 8.7% overall (6.5% males, 14% females). Overall, 28.1% of HIV infections identified in the serosurvey were undiagnosed at jail entry; only 11.5% of these were diagnosed during routine jail testing. Few (11.1%) of the undiagnosed inmates reported injection drug use or being men who have sex with men. Conclusions: About 5%-9% of New York City jail entrants are HIV infected. Of the infected, 28% are undiagnosed; most of whom denied recognized HIV risk factors. To increase inmate's acceptance of routine testing, we are working to eliminate the required separate written consent for HIV testing to allow implementation of the Centers for Disease Control and Prevention-recommended opt out testing model. C1 [Begier, Elizabeth M.] New York City Dept Hlth & Mental Hyg, HIV Epidemiol Serv, New York, NY 10013 USA. [Parvez, Farah] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, Atlanta, GA USA. RP Begier, EM (reprint author), New York City Dept Hlth & Mental Hyg, HIV Epidemiol Serv, 346 Broadway,Room 707, New York, NY 10013 USA. EM ebegier@health.nyc.gov FU Centers for Disease Control and Prevention [5U62PS001026-02] FX Supported in part by cooperative agreement 5U62PS001026-02 with the Centers for Disease Control and Prevention. NR 21 TC 23 Z9 23 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2010 VL 54 IS 1 BP 93 EP 101 DI 10.1097/QAI.0b013e3181c98fa8 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 587OG UT WOS:000277001500013 PM 20042868 ER PT J AU Wang, LY Denniston, M Lee, S Galuska, D Lowry, R AF Wang, Li Y. Denniston, Maxine Lee, Sarah Galuska, Deborah Lowry, Richard TI Long-term Health and Economic Impact of Preventing and Reducing Overweight and Obesity in Adolescence SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Obesity prevention; Adolescents; Long-term impact; Medical costs; Quality-adjusted life years ID BODY-MASS INDEX; MEDICARE EXPENDITURES; YOUNG ADULTHOOD; US CHILDREN; CARE COSTS; AGE; WEIGHT; CHILDHOOD; COHORT; LIFE AB Purpose: Using data from the 2000 National Medical Expenditure Panel Survey and estimates from published studies, this study projected the long-term health and economic impacts of preventing and reducing overweight and obesity in today's adolescents. Methods: We developed a body mass index progression model to project the impact of a 1% point reduction in both overweight and obese adolescents aged 16-17 years at present on the number of non-overweight, overweight, and obese adults at age 40 years. We then estimated its impact on the lifetime medical costs and quality-adjusted life years (QALYs) after age 40. Medical costs (in 2007 dollars) and QALYs were discounted to age 17 years. Results: A 1% point reduction in both overweight and obese adolescents ages 16-17 years at present could reduce the number of obese adults by 52,821 in the future. As a result, lifetime medical care costs after age 40 years would decrease by $586 million and lifetime QALYs would increase by 47,138. In the worst case scenario, the 1% point reduction would lower medical costs by $463 million and increase QALYs by 34,394; in the best case scenario, it would reduce medical costs by $691 million and increase QALYs by 57,149. Conclusions: Obesity prevention in adolescents goes beyond its immediate benefits; it can also reduce medical costs and increase QALYs substantially in later life. Therefore, it is important to include long-term health and economic benefits when quantifying the impact of obesity prevention in adolescents. (C) 2010 Society for Adolescent Medicine. All rights reserved. C1 [Wang, Li Y.; Denniston, Maxine; Lee, Sarah; Lowry, Richard] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Galuska, Deborah] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Wang, LY (reprint author), CDC, Div Adolescent & Sch Hlth, NCCDPHP, 4770 Buford Hwy,MS K33, Atlanta, GA 30341 USA. EM lgw0@cdc.gov NR 40 TC 18 Z9 18 U1 5 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD MAY PY 2010 VL 46 IS 5 BP 467 EP 473 DI 10.1016/j.jadohealth.2009.11.204 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 586SG UT WOS:000276932500010 PM 20413083 ER PT J AU B'Hymer, C Cheever, KL AF B'Hymer, C. Cheever, K. L. TI Evaluation of a Procedure for the Simultaneous Quantification of 4-Ketocyclophosphamide, Cyclophosphamide, and Ifosfamide in Human Urine SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; ANTINEOPLASTIC AGENTS; HEALTH-CARE; HOSPITAL PERSONNEL; ANTICANCER DRUGS; METABOLITES; CONTAMINATION; EXTRACTION; EXPOSURE C1 [B'Hymer, C.; Cheever, K. L.] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Div Appl Res & Technol,Taft Lab C 23, Cincinnati, OH 45226 USA. RP B'Hymer, C (reprint author), Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Div Appl Res & Technol,Taft Lab C 23, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM zky9@cdc.gov NR 28 TC 3 Z9 3 U1 0 U2 3 PU PRESTON PUBL INC PI NILES PA 6600 W TOUHY AVE, NILES, IL 60714-4588 USA SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD MAY-JUN PY 2010 VL 48 IS 5 BP 328 EP 333 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 593DG UT WOS:000277431900002 PM 20515523 ER PT J AU Hamelin, EI Mawhinney, DB Parry, R Kobelski, RJ AF Hamelin, Elizabeth I. Mawhinney, Douglas B. Parry, Ritchard Kobelski, Robert J. TI Quantification of monofluoroacetate and monochloroacetate in human urine by isotope dilution liquid chromatography tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Monofluoroacetate; Monochloroacetate; Tandem mass spectrometry; Compound; Urine excretion; LC/MS/MS; Solid-phase extraction; Chloroacetic acid ID SODIUM MONOFLUOROACETATE; ACID; EXPOSURE; RISK AB The rodenticide monofluoroacetate (MFA) and monochloroacetate (MCA), a chemical intermediate from several chemical syntheses, have been identified as potential agents of chemical terrorism due to their high toxicity. In preparation for response to poisonings and mass exposures, we have developed a quantification method using isotopic dilution to determine MFA and MCA in urine from 50 to 5000 ng/mL. Both analytes were extracted from urine using solid-phase extraction; extraction recoveries were 62% (MFA) and 76% (MCA). The extracts were then separated with isocratic high-performance liquid chromatography and identified using electrospray ionization tandem mass spectrometry, with detection limits of 0.9 and 7.0 ng/mL for MFA and MCA, respectively. Selectivity was established for both analytes with unique chromatographic retention times which were correlated with isotopically labeled internal standards and the use of two mass spectral transitions for each compound. The intra-day variability was less than 5% for both analytes and the inter-day variability was 7% for MFA and 6% for MCA. (C) 2010 Elsevier B.V. All rights reserved. C1 [Hamelin, Elizabeth I.] Battelle Mem Inst, Atlanta, GA 30329 USA. [Parry, Ritchard; Kobelski, Robert J.] Ctr Dis Control & Prevent, Coordinating Ctr Environm Hlth & Injury Prevent, Div Lab Sci Emergency Response & Air Toxicants, Atlanta, GA 30341 USA. [Mawhinney, Douglas B.] So Nevada Water Author LVVWD, Henderson, NV 89015 USA. RP Hamelin, EI (reprint author), Battelle Mem Inst, Century Plaza 1,2987 Clairmont Rd,Suite 450, Atlanta, GA 30329 USA. EM ehamelin@cdc.gov NR 20 TC 3 Z9 3 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD MAY 1 PY 2010 VL 878 IS 15-16 BP 1045 EP 1050 DI 10.1016/j.jchromb.2010.03.008 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 596GC UT WOS:000277672000004 PM 20356806 ER PT J AU Fekedulegn, D Andrew, M Violanti, J Hartley, T Charles, L Burchfiel, C AF Fekedulegn, Desta Andrew, Michael Violanti, John Hartley, Tara Charles, Luenda Burchfiel, Cecil TI Comparison of Statistical Approaches to Evaluate Factors Associated With Metabolic Syndrome SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Article ID COMMON OUTCOMES; RELATIVE RISK; PREVALENCE; REGRESSION; ADULTS AB In statistical analyses, metabolic syndrome as a dependent variable is often utilized in a binary form (presence/absence) where the logistic regression model is used to estimate the odds ratio as the measure of association between health-related factors and metabolic syndrome. Since metabolic syndrome is a common outcome the interpretation of odds ratio as an approximation to prevalence or risk ratio is questionable as it may overestimate its intended target. In addition, dichotomizing a variable that could potentially be treated as discrete may lead to reduced statistical power. In this paper, the authors treat metabolic syndrome as a discrete outcome by defining it as the count of syndrome components. The goal of this study is to evaluate the usefulness of alternative generalized linear models for analysis of metabolic syndrome as a count outcome and compare the results with models that utilize the binary form. Empirical data were used to examine the association between depression and metabolic syndrome. Measures of association were calculated using two approaches; models that treat metabolic syndrome as a binary outcome (the logistic, log-binomial, Poisson, and the modified Poisson regression) and models that utilize metabolic syndrome as discrete/count data (the Poisson and the negative binomial regression). The method that treats metabolic syndrome as a count outcome (Poisson/negative binomial regression model) appears more sensitive in that it is better able to detect associations and hence can serve as an alternative to analyze metabolic syndrome as count dependent variable and provide an interpretable measure of association. C1 [Fekedulegn, Desta; Andrew, Michael; Hartley, Tara; Charles, Luenda; Burchfiel, Cecil] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Violanti, John] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA. RP Fekedulegn, D (reprint author), NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, MS 4050,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM djf7@cdc.gov FU National Institute for Occupational Safety and Health (NIOSH) [200-2003-01580] FX This work was supported by the National Institute for Occupational Safety and Health (NIOSH), contract no. 200-2003-01580. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the NIOSH. No competing financial interests exist. NR 34 TC 7 Z9 7 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1524-6175 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD MAY PY 2010 VL 12 IS 5 BP 365 EP 373 DI 10.1111/j.1751-7176.2010.00264.x PG 9 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 591LN UT WOS:000277302200008 PM 20546380 ER PT J AU Carvalho, MD Pimenta, FC Jackson, D Roundtree, A Ahmad, Y Millar, EV O'Brien, KL Whitney, CG Cohen, AL Beall, BW AF Carvalho, Maria da Gloria Pimenta, Fabiana C. Jackson, Delois Roundtree, Alexis Ahmad, Yusra Millar, Eugene V. O'Brien, Katherine L. Whitney, Cynthia G. Cohen, Adam L. Beall, Bernard W. TI Revisiting Pneumococcal Carriage by Use of Broth Enrichment and PCR Techniques for Enhanced Detection of Carriage and Serotypes SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SEQUENTIAL MULTIPLEX PCR; DETERMINING CAPSULAR SEROTYPES; STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL SECRETIONS; CHILDREN; VACCINE AB The measurement of pneumococcal carriage in the nasopharyngeal reservoir is subject to potential confounders that include low-density and multiple-strain colonization. To compare different methodologies, we picked a random sampling of 100 nasopharyngeal specimens recovered from infants less than 2 years of age who were previously assessed for pneumococcal carriage and serotypes by a conventional method that used direct plating from the transport/storage medium (50 specimens were culture negative and 50 specimens were culture positive for pneumococci). We used a broth enrichment approach and a conventional PCR approach (with and without broth enrichment) to determine pneumococcal carriage and serotypes, and the results were compared to the initial conventional culture-based results. Additionally, we used a lytA-targeted real-time PCR for pneumococcal detection. Broth enrichment for both the culture-based and the PCR-based methods enhanced the isolation of pneumococci and detection of serotype diversity, with the most effective serotype deduction method being one that used broth enrichment prior to sequential multiplex PCR. Similarly, we also found that broth enrichment followed by the lytA-specific real-time PCR was the most sensitive for the detection of apparent pneumococcal carriage. The broth enrichment, conventional multiplex PCR, and real-time PCR approaches used in this study were effective in detecting pneumococcal carriage in the 50 specimens that were negative by conventional direct plating from transport medium (range of numbers of positive specimens, 8/50 to 22/50 [16 to 44%]), and the three different serotyping approaches that used broth enrichment increased the number of serotype identifications from the 100 specimens (12 to 29 additional serotype identifications to be positive). A PCR-based approach that employed a broth enrichment step appeared to best enhance the detection of mixed serotypes and low-density pneumococcal carriage. C1 [Beall, Bernard W.] Ctr Dis Control & Prevent, Streptococcus Lab, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA 30329 USA. [Millar, Eugene V.; O'Brien, Katherine L.] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA. RP Beall, BW (reprint author), Ctr Dis Control & Prevent, Streptococcus Lab, Resp Dis Branch, Div Bacterial Dis, 1600 Clifton Rd NE,Mailstop C02, Atlanta, GA 30329 USA. EM BBeall@CDC.gov NR 17 TC 76 Z9 78 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2010 VL 48 IS 5 BP 1611 EP 1618 DI 10.1128/JCM.02243-09 PG 8 WC Microbiology SC Microbiology GA 592DV UT WOS:000277356600015 ER PT J AU Zhu, Z Abernathy, E Cui, AL Zhang, Y Zhou, SJ Zhang, ZY Wang, CY Wang, TZ Ling, H Zhao, CF Chen, YQ He, JL Sun, L Chen, X Tang, JH Feng, DX Wang, Y Ba, ZM Fan, LX Chen, HY Pan, ZF Zhan, J Chen, H Zhou, SD Zheng, L Gao, H Liang, Y Dai, DF Icenogle, J Xu, WB AF Zhu, Zhen Abernathy, Emily Cui, Aili Zhang, Yan Zhou, Shujie Zhang, Zhenying Wang, Changyin Wang, Tongzhan Ling, Hua Zhao, Chunfang Chen, Yingqiong He, Jilan Sun, Li Chen, Xia Tang, Jihai Feng, Daxin Wang, Yan Ba, Zhuoma Fan, Lixia Chen, Haiyun Pan, Zhengfan Zhan, Jun Chen, Hui Zhou, Shunde Zheng, Lei Gao, Hui Liang, Yong Dai, Defang Icenogle, Joseph Xu, Wenbo TI Rubella Virus Genotypes in the People's Republic of China between 1979 and 2007: a Shift in Endemic Viruses during the 2001 Rubella Epidemic SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MOLECULAR EPIDEMIOLOGY; PHYLOGENETIC ANALYSIS; MEASLES VIRUSES; TRANSMISSION; GENE AB The incidence of rubella cases in China from 1991 to 2007 was reviewed, and the nucleotide sequences from 123 rubella viruses collected during 1999 to 2007 and 4 viral sequences previously reported from 1979 to 1984 were phylogenetically analyzed. Rubella vaccination was not included in national immunization programs in China before 2007. Changes in endemic viruses were compared with incidences of rubella epidemics. The results showed that rubella epidemics occur approximately every 6 to 8 years (1993/1994, 2001, and 2007), and a shift of disease burden to susceptible young adults was observed. The Chinese rubella virus sequences were categorized into 5 of the 13 rubella virus genotypes, 1a, 1E, 1F, 2A, and 2B; cocirculations of these different genotypes were found in China. In Anhui province, a shift in the predominant genotype from 1F and 2B to 1E coincided with the 2001 rubella epidemic. This shift may have occurred throughout China during 2001 to 2007. This study investigated the genotype distribution of rubella viruses in China over a 28-year period to establish an important genetic baseline in China during its prevaccination era. C1 [Abernathy, Emily; Icenogle, Joseph] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Zhu, Zhen; Cui, Aili; Zhang, Yan; Xu, Wenbo] Natl Inst Viral Dis Control & Prevent, WHO WPRO Reg Reference Measles Rubella Lab, Beijing, Peoples R China. [Zhu, Zhen; Cui, Aili; Zhang, Yan; Xu, Wenbo] Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, Beijing, Peoples R China. [Zhou, Shujie; Chen, Xia; Tang, Jihai] Anhui Prov Ctr Dis Control & Prevent, Hefei, Peoples R China. [Zhang, Zhenying; Feng, Daxin] Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Peoples R China. [Wang, Changyin; Wang, Tongzhan] Shandong Prov Ctr Dis Control & Prevent, Jinan, Peoples R China. [Ling, Hua; Zhao, Chunfang; Chen, Yingqiong] Chongqing Prov Ctr Dis Control & Prevent, Chongqing, Peoples R China. [He, Jilan; Sun, Li] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Peoples R China. [Wang, Yan] Liaoning Prov Ctr Dis Control & Prevent, Shenyang, Peoples R China. [Ba, Zhuoma; Fan, Lixia] Qinghai Prov Ctr Dis Control & Prevent, Xining, Peoples R China. [Chen, Haiyun; Pan, Zhengfan] Hainan Prov Ctr Dis Control & Prevent, Haikou, Peoples R China. [Zhan, Jun; Chen, Hui] Ningxia Prov Ctr Dis Control & Prevent, Yinchuan, Peoples R China. [Zhou, Shunde] Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Peoples R China. [Zheng, Lei; Gao, Hui] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan, Peoples R China. [Liang, Yong] Hebei Prov Ctr Dis Control & Prevent, Shijiazhuang, Peoples R China. [Dai, Defang] Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China. RP Icenogle, J (reprint author), Ctr Dis Control & Prevent, Mail Stop C-22,1600 Clifton Rd, Atlanta, GA 30333 USA. EM jci1@cdc.gov; wenbo_xu1@yahoo.com.cn FU WHO HQ; WPRO; Ministry of Health of the People's Republic of China [2008ZX10004-001]; WHO EPI [2008ZX10004-008, 2009ZX10004-201, 2009ZX10004-202] FX We thank all the provincial and prefectural measles and rubella laboratory staffs and the epidemiologists in mainland China for providing clinical specimens, isolates, and epidemiologic data; we thank WHO HQ and WPRO for the technical and financial support.; This work is supported by the Ministry of Health of the People's Republic of China (National Infectious Diseases Surveillance Program: 2008ZX10004-001) and WHO EPI project 2008ZX10004-008, 2009ZX10004-201, and 2009ZX10004-202. NR 36 TC 20 Z9 27 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2010 VL 48 IS 5 BP 1775 EP 1781 DI 10.1128/JCM.02055-09 PG 7 WC Microbiology SC Microbiology GA 592DV UT WOS:000277356600042 PM 20351211 ER PT J AU Bachmann, LH Johnson, RE Cheng, H Markowitz, L Papp, JR Palella, FJ Hook, EW AF Bachmann, Laura H. Johnson, Robert E. Cheng, Hong Markowitz, Lauri Papp, John R. Palella, Frank J., Jr. Hook, Edward W., III TI Nucleic Acid Amplification Tests for Diagnosis of Neisseria gonorrhoeae and Chlamydia trachomatis Rectal Infections SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID UNITED-STATES; GENITAL-INFECTION; MEN; SEX; PREVALENCE; CALIFORNIA; BIAS AB It is uncertain which methods for the diagnosis of rectal gonococcal and chlamydial infection are optimal. This study evaluated the performance of culture and nucleic acid amplification tests (NAATs) for rectal chlamydial and gonococcal diagnosis. From July 2003 until February 2007, 441 rectal test sets were collected from individuals attending a sexually transmitted disease clinic and three HIV clinics who gave a history of anal intercourse or were women at high risk for Neisseria gonorrhoeae or Chlamydia trachomatis infections. Rectal swab specimens were tested using culture and commercial NAATs employing transcription-mediated amplification (TMA), strand displacement amplification (SDA), and PCR amplification. Test performance was evaluated using a rotating standard by which patients were classified as infected if either two or three comparator tests were positive. Test sensitivities for the detection of N. gonorrhoeae ranged from 66.7% to 71.9% for culture to 100% for TMA. Specificities were 99.7% to 100% for culture and greater than 95.5% for all three NAATs. Test sensitivities for C. trachomatis ranged from 36.1% to 45.7% for culture and among NAATS from 91.4% to 95.8% for PCR to 100% for TMA. Specificities of the NAATs ranged from 95.6% to 98.5% (two-of-three standard) and from 88.8% to 91.8% (three-of-three standard). Over 60% and 80% of gonococcal and chlamydial infections, respectively, among men who have sex with men and over 20% of chlamydial infections in women would have been missed if the rectal site had not been tested. Currently available NAATs are more sensitive for the detection of chlamydial and gonococcal infection at the rectal site than is culture. C1 [Bachmann, Laura H.; Hook, Edward W., III] Univ Alabama, Sch Med, Dept Med, Div Infect Dis, Birmingham, AL USA. [Bachmann, Laura H.; Cheng, Hong; Hook, Edward W., III] Univ Alabama, Sch Publ Hlth, Birmingham, AL 35294 USA. [Johnson, Robert E.; Markowitz, Lauri; Papp, John R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bachmann, Laura H.] Birmingham Vet Adm Med Ctr, Birmingham, AL USA. [Palella, Frank J., Jr.] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA. RP Bachmann, LH (reprint author), WG Hefner Med Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM lbachman@wfubmc.edu FU PHS HHS [S2070-22/23] NR 17 TC 70 Z9 74 U1 2 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2010 VL 48 IS 5 BP 1827 EP 1832 DI 10.1128/JCM.02398-09 PG 6 WC Microbiology SC Microbiology GA 592DV UT WOS:000277356600050 PM 20335410 ER PT J AU Chakrabarti, A Marak, RSK Shivaprakash, MR Gupta, S Garg, R Sakhuja, V Singhal, S Baghela, A Dixit, A Garg, MK Padhye, AA AF Chakrabarti, Arunaloke Marak, Rungmei S. K. Shivaprakash, M. R. Gupta, Sunita Garg, Rajiv Sakhuja, V. Singhal, Sanjay Baghela, Abhishek Dixit, Ajai Garg, M. K. Padhye, Arvind A. TI Cavitary Pulmonary Zygomycosis Caused by Rhizopus homothallicus SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GENUS RHIZOPUS; MICROSPORUS-GROUP; STOLONIFER-GROUP; MUCORMYCOSIS; POSACONAZOLE; PHYLOGENY; REVISION AB We report the first two proven cases of cavitary pulmonary zygomycosis caused by Rhizopus homothallicus. The diagnosis in each case was based on histology, culture of the causal agent, and the nucleotide sequence of the D1/D2 region of the 28S ribosomal DNA. C1 [Chakrabarti, Arunaloke; Shivaprakash, M. R.; Gupta, Sunita; Baghela, Abhishek] Postgrad Inst Med Educ & Res, Dept Med Microbiol, Chandigarh 160012, India. [Sakhuja, V.] Postgrad Inst Med Educ & Res, Dept Nephrol, Chandigarh 160012, India. [Garg, M. K.] Postgrad Inst Med Educ & Res, Dept Radiol, Chandigarh 160012, India. [Marak, Rungmei S. K.; Dixit, Ajai] Sanjay Gandhi Postgrad Inst Med Sci, Dept Microbiol, Lucknow 226014, Uttar Pradesh, India. [Garg, Rajiv; Singhal, Sanjay] King George Med Univ, Lucknow, Uttar Pradesh, India. [Padhye, Arvind A.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. RP Chakrabarti, A (reprint author), Postgrad Inst Med Educ & Res, Dept Microbiol, Chandigarh 160012, India. EM arunaloke@hotmail.com OI Rudramurthy, Shivaprakash/0000-0002-9097-9253 FU Indian Council of Medical Research, New Delhi, India FX We thank the Indian Council of Medical Research, New Delhi, India, for their support in purchasing the sequencer for the Centre of Advance Research in Medical Mycology.; None of us has an association that might pose a conflict of interest relevant to this report. NR 22 TC 9 Z9 9 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2010 VL 48 IS 5 BP 1965 EP 1969 DI 10.1128/JCM.01272-09 PG 5 WC Microbiology SC Microbiology GA 592DV UT WOS:000277356600082 PM 20200286 ER PT J AU Levy, SE Giarelli, E Lee, LC Schieve, LA Kirby, RS Cunniff, C Nicholas, J Reaven, J Rice, CE AF Levy, Susan E. Giarelli, Ellen Lee, Li-Ching Schieve, Laura A. Kirby, Russell S. Cunniff, Christopher Nicholas, Joyce Reaven, Judy Rice, Catherine E. TI Autism Spectrum Disorder and Co-occurring Developmental, Psychiatric, and Medical Conditions Among Children in Multiple Populations of the United States SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Article DE autism; autism spectrum; pervasive developmental disorder-not otherwise specified; Asperger Syndrome; co-occurring diagnoses; medical disorders ID DEFICIT HYPERACTIVITY DISORDER; HEALTH-CARE USE; ASPERGER-SYNDROME; PRESCHOOL-CHILDREN; PREVALENCE; DISABILITIES; ATTENTION; SURVEILLANCE; COMORBIDITY; DIAGNOSIS AB Background: Autism spectrum disorders (ASDs) often co-occur with other developmental, psychiatric, neurologic, or medical diagnoses. Objective: This study examined co-occurring non-ASD diagnoses and symptoms in a population-based cohort of 8 year olds identified with ASD. Method: Data on 2,568 children meeting surveillance case definition for ASD were collected by a multi-site surveillance program. Information was systematically abstracted and reviewed from existing health and education source records and systematically entered into a summary record in a secure database. Results: Eighty-one percent of study children were male; 63% white, 23% black, 14% Hispanic, Asian, or not stated. When age of ASD classification was available, 20% were classified before age 3 years, 36% between ages 3 and 5 years, and 44% after age 5 years. The co-occurrence of >= 1 non-ASD developmental diagnoses was 83%, >= 1 psychiatric diagnoses was 10%, >= 1 neurologic diagnoses was 16%, and at least one possibly causative genetic or neurologic diagnosis was 4%. Children with a previous ASD classification and co-occurring psychiatric or neurologic conditions were more likely to be diagnosed or classified at a later age. Each category of co-occurring non-ASD diagnosis was significantly increased in children whose records did not include an ASD diagnosis or educational classification but who met surveillance criteria for ASD. Conclusions: These data highlight the need for clinicians to keep in mind the high prevalence of associated diagnoses with an ASD diagnosis, and the possibility that in younger children other symptoms or disorders may be masking or obscuring core symptoms of ASD, which would lead to a diagnosis. C1 [Levy, Susan E.] Childrens Hosp Philadelphia, Reg Autism Ctr, Div Child Dev Rehabil & Metab Dis, Philadelphia, PA 19104 USA. [Giarelli, Ellen] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. [Lee, Li-Ching] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Schieve, Laura A.; Rice, Catherine E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA. [Cunniff, Christopher] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA. [Nicholas, Joyce] Med Univ S Carolina, Charleston, SC 29425 USA. [Reaven, Judy] Univ Colorado, Sch Med, JFK Partners, Denver, CO USA. RP Levy, SE (reprint author), Childrens Hosp Philadelphia, Reg Autism Ctr, Div Child Dev Rehabil & Metab Dis, Childrens Seashore House,3405 Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM levys@email.chop.edu RI Rice, Catherine/D-6305-2016 FU Centers for Disease Control and Prevention (CDC) FX The data represented in this paper were collected by the Autism and Developmental Disabilities Monitoring (ADDM) Network Surveillance Year 2002 supported by the Centers for Disease Control and Prevention (CDC). NR 30 TC 90 Z9 90 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-206X EI 1536-7312 J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD MAY PY 2010 VL 31 IS 4 BP 267 EP 275 DI 10.1097/DBP.0b013e3181d5d03b PG 9 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA 597PE UT WOS:000277769600001 PM 20431403 ER PT J AU Otto, C Hlavsa, M AF Otto, Charles, III Hlavsa, Michele TI Keep on Swimming! SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material C1 [Otto, Charles, III] CDC, EHSB, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Otto, C (reprint author), CDC, EHSB, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F60, Atlanta, GA 30341 USA. EM cotto@cdc.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAY PY 2010 VL 72 IS 9 BP 25 EP 27 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 591OO UT WOS:000277311000005 PM 20464908 ER PT J AU Lakind, JS Naiman, DQ Hays, SM Aylward, LL Blount, BC AF Lakind, Judy S. Naiman, Daniel Q. Hays, Sean M. Aylward, Lesa L. Blount, Benjamin C. TI Public health interpretation of trihalomethane blood levels in the United States: NHANES 1999-2004 SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE THMs; blood; chloroform; biomonitoring equivalent; DBPs; NHANES ID EQUIVALENTS EXPERT WORKSHOP; BIOMONITORING EQUIVALENTS; WATER CONTAMINANTS; DRINKING-WATER; BY-PRODUCTS; EXPOSURE; TRICHLOROETHYLENE; POPULATION; GUIDELINES AB Trihalomethanes (THMs) can form as byproducts during drinking water disinfection, which is crucial for limiting human exposure to disease-causing pathogens. The US Environmental Protection Agency (USEPA), recognizing both the importance of water disinfection for public health protection and potential risks associated with THM exposure, developed disinfection byproduct rules with the parallel goals of ensuring safe drinking water and limiting the levels of THMs in public water systems. The National Health and Nutrition Examination Survey (NHANES) THM blood data can be used as a means for assessing US population exposures to THMs; biomonitoring equivalents (BEs) can provide human health risk-based context to those data. In this paper, we examine the blood THM levels in the 1999-2004 NHANES data to (i) determine weighted population percentiles of blood THMs, (ii) explore whether gender and/or age are associated with blood THM levels, (iii) determine whether temporal trends can be discerned over the 6-year timeframe, and (iv) draw comparisons between population THM blood levels and BEs. A statistically significant decrease in blood chloroform levels was observed across the 1999-2004 time period. Age-related differences in blood chloroform levels were not consistent and no gender-related differences in blood chloroform levels were observed. The concentrations of all four THMs in the blood of US residents from the 2003 to 2004 NHANES dataset are below BEs consistent with the current US EPA reference doses. For bromodichloromethane and dibromochloromethane, the measured median blood concentrations in the United States are within the BEs for the 10(-6) and 10(-4) cancer risk range, whereas measured values for bromoform generally fall below the 10(-6) cancer risk range. These assessments indicate that general population blood concentrations of THMs are in a range considered to be a low to medium priority for risk assessment follow-up, according to the guidelines for interpretation of biomonitoring data using BEs. Journal of Exposure Science and Environmental Epidemiology (2010) 20, 255 -262; doi:10.1038/jes.2009.35; published online 24 June 2009 C1 [Lakind, Judy S.] LaKind Associates LLC, Catonsville, MD 21228 USA. [Lakind, Judy S.] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA. [Naiman, Daniel Q.] Johns Hopkins Univ, Dept Appl Math & Stat, Baltimore, MD USA. [Hays, Sean M.] Summit Toxicol LLP, Lyons, CO USA. [Aylward, Lesa L.] Summit Toxicol LLP, Falls Church, VA USA. [Blount, Benjamin C.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Lakind, JS (reprint author), LaKind Associates LLC, 106 Oakdale Ave, Catonsville, MD 21228 USA. EM lakindassoc@comcast.net OI Aylward, Lesa/0000-0003-3191-8175 NR 27 TC 9 Z9 9 U1 0 U2 12 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAY PY 2010 VL 20 IS 3 BP 255 EP 262 DI 10.1038/jes.2009.35 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 586YU UT WOS:000276952700007 PM 19550438 ER PT J AU Schier, JG Wolkin, AF Valentin-Blasini, L Belson, MG Kieszak, SM Rubin, CS Blount, BC AF Schier, Joshua G. Wolkin, Amy F. Valentin-Blasini, Lisa Belson, Martin G. Kieszak, Stephanie M. Rubin, Carol S. Blount, Benjamin C. TI Perchlorate exposure from infant formula and comparisons with the perchlorate reference dose SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE perchlorate; infant formula; reference dose; exposure ID TANDEM MASS-SPECTROMETRY; DRINKING-WATER; THYROID-FUNCTION; CONGENITAL HYPOTHYROIDISM; ION CHROMATOGRAPHY; ACTIVE-TRANSPORT; BREAST-MILK; HEALTH; PREGNANCY; IODIDE AB Perchlorate exposure may be higher in infants compared with older persons, due to diet (infant formula) and body weight versus intake considerations. Our primary objective was to quantitatively assess perchlorate concentrations in commercially available powdered infant formulas (PIFs). Secondary objectives were: (1) to estimate exposure in infants under different dosing scenarios and compare them with the perchlorate reference dose (RfD); (2) estimate the perchlorate concentration in water used for preparing PIFs that would result in a dose exceeding the RfD; and (3) estimate iodine intakes from PIFs. We quantified perchlorate levels in three samples (different lot numbers) of reconstituted PIF (using perchlorate-free water) from commercial brands of PIF in each of the following categories: bovine milk-based with lactose, soy-based, bovine milk-based but lactose-free, and elemental (typically consisting of synthetic amino acids). Exposure modeling was conducted to determine whether the RfD might be exceeded in 48 dosing scenarios that were dependent on age, centile energy intake per unit of body weight, body weight percentile, and PIF perchlorate concentration. We obtained three different samples in each of the five brands of bovine-and soy-based PIF, three different samples in each of the three brands of lactose-free PIF, and three different samples in two brands of elemental PIF. The results were as follows: bovine milk-based with lactose (1.72 mu g/l, range: 0.68-5.05); soy-based (0.21 mu g/l, range: 0.10-0.44); lactose-free (0.27 mu g/l, range: 0.03-0.93); and elemental (0.18 mu g/l, range: 0.08-0.4). Bovine milk-based PIFs with lactose had a significantly higher concentration of perchlorate (P<0.05) compared with all. Perchlorate was a contaminant of all commercially available PIFs tested. Bovine milk-based PIFs with lactose had a significantly higher perchlorate concentration perchlorate than soy, lactose-free, and elemental PIFs. The perchlorate RfD may be exceeded when certain bovine milk-based PIFs are ingested and/or when PIFs are reconstituted with perchlorate-contaminated water. Journal of Exposure Science and Environmental Epidemiology (2010) 20, 281-287; doi:10.1038/jes.2009.18; published online 18 March 2009 C1 [Valentin-Blasini, Lisa; Blount, Benjamin C.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Schier, Joshua G.; Wolkin, Amy F.; Belson, Martin G.; Kieszak, Stephanie M.; Rubin, Carol S.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Schier, JG (reprint author), Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, CDC NCEH EHHE HSB, MS F-57,4770 Buford Highway NE, Chamblee, GA 30341 USA. EM jschier@cdc.gov RI Schier, Joshua/F-9861-2013 NR 39 TC 12 Z9 13 U1 0 U2 11 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAY PY 2010 VL 20 IS 3 BP 281 EP 287 DI 10.1038/jes.2009.18 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 586YU UT WOS:000276952700010 PM 19293845 ER PT J AU Ward, TJ Evans, P Wiedmann, M Usgaard, T Roof, SE Stroika, SG Hise, K AF Ward, Todd J. Evans, Peter Wiedmann, Martin Usgaard, Thomas Roof, Sherry E. Stroika, Steven G. Hise, Kelley TI Molecular and Phenotypic Characterization of Listeria monocytogenes from US Department of Agriculture Food Safety and Inspection Service Surveillance of Ready-to-Eat Foods and Processing Facilities SO JOURNAL OF FOOD PROTECTION LA English DT Article ID INTESTINAL EPITHELIAL-CELLS; GENETIC-CHARACTERIZATION; POSITIVE SELECTION; GENOTYPING ASSAY; UNITED-STATES; INTERNALIN-A; VIRULENCE; STRAINS; INLA; DISTINCT AB A panel of 501 Listeria monocytogenes isolates obtained from the U.S. Department of Agriculture Food Safety and Inspection Service monitoring programs for ready-to-eat (RTE) foods were subtyped by multilocus genotyping (MLGT) and by sequencing the virulence gene inIA, which codes for intemalin. MLGT analyses confirmed that clonal lineages associated with previous epidemic outbreaks were rare (7.6%) contaminants of RTE meat and poultry products and their production environments. Conversely, sequence analyses revealed mutations leading to 11 different premature stop codons (PMSCs) in inIA, including three novel PMSC mutations, and revealed that the frequency of these virulence-attenuating mutations among RTE isolates (48.5%) was substantially higher than previously appreciated. Significant differences (P < 0.001) in the frequency of inIA PMSCs were observed between lineages and between major serogroups, which could partially explain differences in association of these subtypes with human listeriosis. Interrogation of single-nucleotide polymorphisms responsible for PMSCs in inIA improved strain resolution among isolates with the 10 most common pulsed-field gel electrophoresis (PFGE) patterns, 8 of which included isolates with a PMSC in inIA. The presence or absence of PMSCs in inIA accounted for significant differences (P < 0.05) in Caco-2 invasion efficiencies among isolates with identical PFGE patterns, and the proportion of PulseNet entries from clinical sources was significantly higher (P < 0.001) for PFGE patterns exclusively from isolates with full-length inIA. These results indicated that integration of PFGE and DNA sequence based subtyping provides an improved framework for prediction of relative risk associated with L. monocyto genes strains from RTE foods. C1 [Ward, Todd J.; Usgaard, Thomas] ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, USDA, Peoria, IL 61604 USA. [Evans, Peter] Food Safety & Inspect Serv, Div Microbiol, Off Publ Hlth Sci, USDA, Washington, DC 20250 USA. [Wiedmann, Martin; Roof, Sherry E.] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA. [Stroika, Steven G.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Ward, TJ (reprint author), ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, USDA, Peoria, IL 61604 USA. EM todd.ward@ars.usda.gov RI Wiedmann, Martin/A-9683-2008 OI Wiedmann, Martin/0000-0002-4168-5662 NR 45 TC 30 Z9 30 U1 1 U2 14 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD MAY PY 2010 VL 73 IS 5 BP 861 EP 869 PG 9 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 595DR UT WOS:000277591400008 PM 20501037 ER PT J AU Martin, MA May, AL Frisco, ML AF Martin, Molly A. May, Ashleigh L. Frisco, Michelle L. TI Equal Weights but Different Weight Perceptions among US Adolescents SO JOURNAL OF HEALTH PSYCHOLOGY LA English DT Article DE adolescents; body image; Body Mass Index; gender; race ID BODY-IMAGE; SECULAR TRENDS; BEHAVIORS; HEALTH; GIRLS; ASSOCIATION; OVERWEIGHT; FEMALES; HEIGHT; GENDER AB We investigate sex and race/ethnic differences in adolescents' perceptions of the same objectively measured weight in a nationally representative US sample. At the same BMI z-score, girls perceive themselves as heavier than boys. Regardless of sex and relative to Whites, African-Americans perceive the same BMI z-score as leaner and Native Americans are more likely to perceive objectively heavier weights as 'about the right weight'. Asian boys consider a narrower weight range to be 'about the right weight' relative to White boys, and Asian girls are less likely than White girls to perceive objectively lower weights as 'about the right weight'. C1 [Martin, Molly A.] Penn State Univ, Dept Sociol, University Pk, PA 16802 USA. [May, Ashleigh L.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Martin, MA (reprint author), Penn State Univ, Dept Sociol, 211 Oswald Tower, University Pk, PA 16802 USA. EM mmartin@pop.psu.edu FU NICHD NIH HHS [R01 HD050144, R01-HD050144, R24 HD041025] NR 34 TC 14 Z9 14 U1 1 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1359-1053 J9 J HEALTH PSYCHOL JI J. Health Psychol. PD MAY PY 2010 VL 15 IS 4 BP 493 EP 504 DI 10.1177/1359105309355334 PG 12 WC Psychology, Clinical SC Psychology GA 594KR UT WOS:000277537100002 PM 20460406 ER PT J AU Bukh, J Meuleman, P Tellier, R Engle, RE Feinstone, SM Eder, G Satterfield, WC Govindarajan, S Krawczynski, K Miller, RH Leroux-Roels, G Purcell, RH AF Bukh, Jens Meuleman, Philip Tellier, Raymond Engle, Ronald E. Feinstone, Stephen M. Eder, Gerald Satterfield, William C. Govindarajan, Sugantha Krawczynski, Krzysztof Miller, Roger H. Leroux-Roels, Geert Purcell, Robert H. TI Challenge Pools of Hepatitis C Virus Genotypes 1-6 Prototype Strains: Replication Fitness and Pathogenicity in Chimpanzees and Human Liver-Chimeric Mouse Models SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CELL-CULTURE-SYSTEMS; INFECTIOUS IN-VIVO; 6 MAJOR GENOTYPES; UPA-SCID MOUSE; INOCULATED CHIMPANZEES; FULMINANT-HEPATITIS; NUCLEOTIDE-SEQUENCE; MOLECULAR CLONE; CDNA-CLONE; TRANSCRIPTS AB Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer of acute-phase plasma pools in additional animals. The courses of first- and second-passage infections were similar, with early appearance of viremia, HCV RNA titers of >10(4.7) IU/mL, and development of acute hepatitis; the chronicity rate was 56%. The challenge pools had titers of 10(3)-10(5) chimpanzee infectious doses/mL. Human liver-chimeric mice developed high-titer infections after inoculation with the challenge viruses of genotypes 1-6. Inoculation studies with different doses of the genotype 1b pool suggested that a relatively high virus dose is required to consistently infect chimeric mice. The challenge pools represent a unique resource for studies of HCV molecular virology and for studies of pathogenesis, protective immunity, and vaccine efficacy in vivo. C1 [Bukh, Jens; Tellier, Raymond; Engle, Ronald E.; Miller, Roger H.; Purcell, Robert H.] NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Feinstone, Stephen M.] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. [Satterfield, William C.] Univ Texas MD Anderson Canc Ctr, Dept Vet Sci, Michale E Keeling Ctr Comparat Med & Res, Bastrop, TX USA. [Govindarajan, Sugantha] Univ So Calif, Rancho Los Amigos Med Ctr, Liver Res Lab, Downey, CA 90242 USA. [Krawczynski, Krzysztof] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Bukh, Jens] Copenhagen Univ Hosp, Copenhagen Hepatitis Program CO HEP C, Dept Infect Dis, Hvidovre, Denmark. [Bukh, Jens] Copenhagen Univ Hosp, Clin Res Ctr, Hvidovre, Denmark. [Bukh, Jens] Univ Copenhagen, Dept Int Hlth Immunol & Microbiol, Fac Hlth Sci, Copenhagen, Denmark. [Eder, Gerald] Karl Landsteiner Inst Epidemiol Infect Disorders, St Polten, Austria. [Meuleman, Philip; Leroux-Roels, Geert] Ghent Univ & Hosp, Ctr Vaccinol, Ghent, Belgium. RP Bukh, J (reprint author), NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bldg 50,50 S Dr MSC 8009, Bethesda, MD 20892 USA. EM jbukh@niaid.nih.gov RI Meuleman, Philip/H-2899-2013 OI Meuleman, Philip/0000-0001-6821-234X FU National Institute of Allergy and Infectious Diseases, National Institutes of Health [N01-A0-2713]; University of Copenhagen; Lundbeck Foundation; Ghent University [01G00507]; Belgian State via the Interuniversity Attraction Poles Program [P6/36 HEPRO]; European Union; Research Foundation Flanders (FWO-Vlaanderen) FX Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (contract N01-A0-2713); University of Copenhagen (professorship to J.B.); Lundbeck Foundation (external funding to J.B.); Ghent University (Concerted Action Grant 01G00507); the Belgian State via the Interuniversity Attraction Poles Program (grant P6/36 HEPRO); European Union (6th Framework-HEPACIVAC); The Research Foundation Flanders (FWO-Vlaanderen; postdoctoral fellowship to P.M.). NR 50 TC 43 Z9 43 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2010 VL 201 IS 9 BP 1381 EP 1389 DI 10.1086/651579 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 577UB UT WOS:000276248400015 PM 20353362 ER PT J AU Harris, JR Quick, RE AF Harris, Julie R. Quick, Robert E. TI Safe Water and HIV-Exposed Infants Reply SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 [Harris, Julie R.; Quick, Robert E.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. RP Harris, JR (reprint author), 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30329 USA. EM ggt5@cdc.gov NR 4 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2010 VL 201 IS 9 BP 1443 EP 1444 DI 10.1086/651700 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 577UB UT WOS:000276248400024 ER PT J AU Brown, CR Moore, AT Young, GR Komar, N AF Brown, Charles R. Moore, Amy T. Young, Ginger R. Komar, Nicholas TI Persistence of Buggy Creek Virus (Togaviridae, Alphavirus) for Two Years in Unfed Swallow Bugs (Hemiptera: Cimicidae: Oeciacus vicarius) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE alphavirus; Buggy Creek virus; cliff swallow; Oeciacus vicarius; Petrochelidon pyrrhonota ID BORNE ENCEPHALITIS-VIRUS; EQUINE ENCEPHALOMYELITIS VIRUS; CULEX-TARSALIS DIPTERA; WINTER SURVIVAL; VERTEBRATE HOSTS; CLIFF SWALLOWS; TICKS; CULICIDAE; INFECTION; TRANSMISSION AB Alphaviruses (Togaviridae) have rarely been found to persist for long in the adult insects that serve as their vectors. The ectoparasitic swallow bug (Hemiptera: Cimicidae: Oeciacus vicarius Horvath), the vector for Buggy Creek virus (BCRV; Togaviridae, Alphavirus), lives year-round in the mud nests of its host, the cliff swallow (Petrochelidon pyrrhonota Vieillot). We measured the prevalence of BCRV in swallow bugs at sites with cliff swallows present and at the same sites after cliff swallows had been absent for 2 yr. We collected bugs directly from cliff swallow nests in the field and screened bug pools with BCRV-specific real-time-polymerase chain reaction (RT-PCR) and plaque assay. At two colony sites last occupied by birds 2 yr earlier, we found 12.5 and 55.6% of bug pools positive for BCRV RNA by RT-PCR. Infection rates (per 1,000 bugs) for these sites were 1.32 and 7.39. RNA prevalence in the unfed bugs was not significantly different from that in fed bugs 2 yr earlier at the same sites. The RNA-positive samples from unfed bugs failed to yield cytopathic BCRV by Vero-cell plaque assay. However, viral RNA concentrations did not differ between unfed bugs and bugs at active sites, and over 84% of positive bug pools were cytopathic to Vero cells 4-5 wk later, after cliff swallows moved into one of the colony sites. These data demonstrate the persistence of potentially infectious BCRV in unfed swallow bugs for at least 2 yr in nature. C1 [Brown, Charles R.; Moore, Amy T.] Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA. [Young, Ginger R.; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. RP Brown, CR (reprint author), Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA. EM charles-brown@utulsa.edu FU National Institutes of Health [AI057569]; National Science Foundation [DEB-0075199, DEB-0514824] FX We thank Alex Brazeal, Mary Bomberger Brown, Eric Edwards, Bryce Hatfield, Allison Johnson, Sarah Knutie, Sara Robinson, and Jessica Tipple for help with field or laboratory work. The University of Nebraska-Lincoln allowed us to use the facilities of the Cedar Point Biological Station, and the Union Pacific Railroad permitted us access to their property. This work was funded by the National Institutes of Health (AI057569) and the National Science Foundation (DEB-0075199, DEB-0514824). Valerie O'Brien, William Reisen, and two anonymous reviewers provided helpful comments on the manuscript. NR 51 TC 7 Z9 8 U1 2 U2 3 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2010 VL 47 IS 3 BP 436 EP 441 DI 10.1603/ME09288 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 595FV UT WOS:000277597000018 PM 20496591 ER PT J AU Hodges, LR Rose, LJ O'Connell, H Arduino, MJ AF Hodges, Lisa R. Rose, Laura J. O'Connell, Heather Arduino, Matthew J. TI National validation study of a swab protocol for the recovery of Bacillus anthracis spores from surfaces SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacillus anthracis spores; Swabs; Surface sampling ID NONPOROUS SURFACES; INHALATIONAL ANTHRAX; QUANTITATIVE PCR; CONTAMINATION; WASHINGTON; COLLECTION; DC AB Twelve Laboratory Response Network (LRN) affiliated laboratories participated in a validation study of a macrofoam swab protocol for the recovery, detection, and quantification of viable B. anthracis (BA) Sterne spores from steel surfaces. CDC personnel inoculated steel coupons (26 cm(2)) with 1-4 log(10) BA spores and recovered them by sampling with pre-moistened macrofoam swabs. Phase 1 (P1) of the study evaluated swabs containing BA only, while dust and background organisms were added to swabs in Phase 2 (P2) to mimic environmental conditions. Laboratories processed swabs and enumerated spores by culturing eluted swab suspensions and counting colonies with morphology consistent with BA. Processed swabs were placed in enrichment broth, incubated 24 h, and cultured by streaking for isolation. Real-time PCR was performed on selected colonies from P2 samples to confirm the identity of BA. Mean percent recovery (%R) of spores from the surface ranged from 15.8 to 31.0% (P1) and from 27.9 to 55.0% (P2). The highest mean percent recovery was 31.0% (sd 10.9%) for P1(4 log(10) inoculum) and 55.0% (sd 27.6%) for P2 (1 log(10) inoculum). The overall %R was higher for P2 (446%) than P1 (24.1%), but the overall reproducibility (between-lab variability) was lower in P2 than in P1 (25.0 vs 16.5%CV, respectively). The overall precision (within-lab variability) was close to identical for P1 and P2 (44.0 and 4-4.1, respectively), but varied greatly between inoculum levels. The protocol demonstrated linearity in %R over the three inoculum levels and is able to detect between 26 and 5 x 10(6) spores/26 cm(2). Sensitivity as determined by culture was >98.3% for both phases and all inocula, suggesting that the culture method maintains sensitivity in the presence of contaminants. The enrichment broth method alone was less sensitive for sampled swabs (66.4%) during P2, suggesting that the presence of background organisms inhibited growth or isolation of BA from the broth. The addition of real-time PCR testing to the assay increased specificity from >85.4% to >95.0% in P2. Although the precision was low at the 1 log(10) inoculum level in both phases (59.0 and 50.2%), this swab processing protocol, was sensitive, specific, precise, and reproducible at 2-4 log(10)/26 cm(2) spore concentrations. Published by Elsevier B.V. C1 [Hodges, Lisa R.; Rose, Laura J.; O'Connell, Heather; Arduino, Matthew J.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Rose, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Healthcare Qual Promot, 1600 Clifton Rd,Mail Stop C16, Atlanta, GA 30333 USA. EM lrose@cdc.gov FU Oak Ridge Universities; Office of Terrorism Preparedness and Emergency Response, CDC FX Funding for L. Hodges was provided by a CDC-ORISE fellowship from Oak Ridge Universities. Project funding was provided by the Office of Terrorism Preparedness and Emergency Response, CDC. We thank the Laboratory Response Network review committee, and the following participating laboratories: Florida Dept. Health, Bureau of Laboratories, Jacksonville, FL; Lawrence Livermore National Laboratory, Livermore, CA; Los Angeles County Department of Public Health, Public Health Laboratory, Los Angeles, CA; Minnesota Department of Health, Public Health Laboratory, Health, St. Paul, MN; New York City Department of Health, Public Health Laboratory, Health, NY, NY; New York State Department of Health, Wadsworth Center, Albany, NY; Pennsylvania Department of Health, Bureau of Laboratories, Lionville, PA; Texas Department of State Health Serveces, Laboratory Services, Austin, TX; United States Department of Agriculture, Food Safety and Inspection Service, Office of Public Health Science, Food Emergency Response Network Division, Athens, GA; Virginia Department of General Services, Division of Consolidated Laboratory Services, Richmond, VA; and Washington Department of Health, Public Health Laboratories, Shoreline, WA. NR 25 TC 27 Z9 27 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD MAY PY 2010 VL 81 IS 2 BP 141 EP 146 DI 10.1016/j.mimet.2010.02.010 PG 6 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 599YJ UT WOS:000277949900009 PM 20193714 ER PT J AU Letant, SE Kane, SR Murphy, GA Alfaro, TM Hodges, LR Rose, LJ Raber, E AF Letant, S. E. Kane, S. R. Murphy, G. A. Alfaro, T. M. Hodges, L. R. Rose, L. J. Raber, E. TI Most-Probable-Number Rapid Viability PCR method to detect viable spores of Bacillus anthracis in swab samples SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacillus anthracis; Polymerase Chain Reaction; Rapid Viability; Spore ID WATER AB A comparison of Most-Probable-Number Rapid Viability (MPN RV) PCR and traditional culture methods for the quantification of Bacillus anthracis Sterne spores in macrofoam swabs from a multi-center validation study was performed. The purpose of the study was to compare environmental swab processing methods for recovery, detection, and quantification of viable B. anthracis spores from surfaces. Results show that spore numbers provided by the MPN RV-PCR method were typically within 1-log of the values from a plate count method for all three levels of spores tested (3.1 x 10(4), 400, and 40 spores sampled from surfaces with swabs) even in the presence of debris. The MPN method tended to overestimate the expected result, especially at lower spore levels. Blind negative samples were correctly identified using both methods showing a lack of cross contamination. In addition to detecting low levels of spores in environmental conditions, the MPN RV-PCR method is specific, and compatible with automated high-throughput sample processing and analysis protocols, enhancing its utility for characterization and clearance following a biothreat agent release. (C) 2010 Elsevier B.V. All rights reserved. C1 [Letant, S. E.; Kane, S. R.; Murphy, G. A.; Alfaro, T. M.; Raber, E.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Hodges, L. R.; Rose, L. J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. RP Kane, SR (reprint author), Lawrence Livermore Natl Lab, 7000 East Ave L-452, Livermore, CA 94550 USA. EM kane11@llnl.gov FU U.S. Department of Energy [DE-AC52-07NA27344]; Department of Homeland Security; Defense Threat Reduction Agency FX This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Funding for this research was provided by the Department of Homeland Security and the Defense Threat Reduction Agency. NR 5 TC 8 Z9 8 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD MAY PY 2010 VL 81 IS 2 BP 200 EP 202 DI 10.1016/j.mimet.2010.02.011 PG 3 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 599YJ UT WOS:000277949900019 PM 20193716 ER PT J AU McGuire, LC Bouldin, EL Andresen, EM Anderson, LA AF McGuire, L. C. Bouldin, E. L. Andresen, E. M. Anderson, L. A. TI Examining modifiable health behaviors, body weight, and use of preventive health services among caregivers and non-caregivers aged 65 years and older in Hawaii, Kansas, and Washington using 2007 BRFSS SO JOURNAL OF NUTRITION HEALTH & AGING LA English DT Article DE Caregiving; behavioral risk factor surveillance system; health behaviors ID QUALITY-OF-LIFE; FACTOR SURVEILLANCE SYSTEM; FAMILY CAREGIVERS; RISK; ADULTS; DISABILITY; DEMENTIA AB To examine the associations among health behaviors, healthy body weight, and use of preventive services of adults 65 years and older using the 2007 Behavioral Risk Factor Surveillance System (BRFSS) as a function of caregiving status. Participants (N=6,138) residing in the states of Hawaii, Kansas, and Washington completed questions about caregiving. We examined if there were any associations among body weight-having a healthy weight (body mass index 18.5-24.9 kg/m2); modifiable health behaviors-not smoking, consuming a parts per thousand currency sign1 alcoholic beverage per day, consuming at least five fruits or vegetables daily, participating in moderate-to-vigorous physical activity during the average week; and using preventive services-receiving an annual influenza immunization, and ever receiving a pneumococcal immunization. The two groups did not differ significantly on the modifiable health behaviors of fruit and vegetable consumption, smoking status, or alcohol consumption, or having a healthy weight. Caregivers were significantly more likely to meet physical activity recommendations than non-caregivers (54.1%, 42.0%, respectively, p < 0.001). No significant differences were found between caregivers and non-caregivers on receiving influenza and pneumococcal immunization. Older adults who are caregivers are more likely than other older adults to meet government recommendations for physical activity; however, they have similar patterns of engaging in other health behaviors, including health eating and use of preventive services. C1 [McGuire, L. C.] Ctr Dis Control & Prevent, Div Injury Response, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Bouldin, E. L.; Andresen, E. M.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Epidemiol & Biostat, Gainesville, FL USA. [Anderson, L. A.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Anderson, L. A.] Emory Univ, Dept Behav Sci & Hlth Educ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP McGuire, LC (reprint author), Ctr Dis Control & Prevent, Div Injury Response, Natl Ctr Injury Prevent & Control, 4770 Buford Highway,NE,Mail Stop F-62, Atlanta, GA 30341 USA. EM LMcGuire@cdc.gov OI Bouldin, Erin/0000-0001-7550-309X NR 34 TC 6 Z9 6 U1 0 U2 5 PU SPRINGER FRANCE PI PARIS PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE SN 1279-7707 J9 J NUTR HEALTH AGING JI J. Nutr. Health Aging PD MAY PY 2010 VL 14 IS 5 BP 373 EP 379 DI 10.1007/s12603-010-0083-0 PG 7 WC Geriatrics & Gerontology; Nutrition & Dietetics SC Geriatrics & Gerontology; Nutrition & Dietetics GA 590SK UT WOS:000277247600007 PM 20424805 ER PT J AU Bailey, RL Thomas, CA Deubner, DC Kent, MS Kreiss, K Schuler, CR AF Bailey, Rachel L. Thomas, Carrie A. Deubner, David C. Kent, Michael S. Kreiss, Kathleen Schuler, Christine R. TI Evaluation of a Preventive Program to Reduce Sensitization at a Beryllium Metal, Oxide, and Alloy Production Plant SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID LYMPHOCYTE-PROLIFERATION TEST; DISEASE; FACILITY; WORKERS; SURVEILLANCE; EFFICACY; RISK AB Objective: We evaluated a workplace preventive program's effectiveness, which emphasized skin and respiratory protection, workplace cleanliness, and beryllium migration control in lowering beryllium sensitization. Methods: We compared sensitization prevalence and incidence rates for workers hired before and after the program using available cross sectional and longitudinal surveillance data. Results: Sensitization prevalence was 8.9% for the Pre-Program Group and 2.1% for the Program Group. The sensitization incidence rate was 3.7/1000 person-months for the Pre-Program Group and 1.7/1000 person-months for the Program Group. After making adjustments for potential selection and information bias, sensitization prevalence for the Pre-Program Group was 3.8 times higher (95% CI = 1.5 to 9.3) than the Program Group. The sensitization incidence rate ratio comparing the Pre-Program Group to the Program Group was 1.6 ( 95% CI = 0.8 to 3.6). Conclusions: This preventive program reduced the prevalence of but did not eliminate beryllium sensitization. C1 [Bailey, Rachel L.] Ctr Dis Control & Prevent, Div Resp Dis Studies, NIOSH, Field Studies Branch, Morgantown, WV 26505 USA. [Deubner, David C.; Kent, Michael S.] Brush Wellman Inc, Elmore, OH USA. RP Bailey, RL (reprint author), Ctr Dis Control & Prevent, Div Resp Dis Studies, NIOSH, Field Studies Branch, 1095 Willowdale Rd,MS H2800, Morgantown, WV 26505 USA. EM RLBailey@cdc.gov NR 17 TC 16 Z9 17 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2010 VL 52 IS 5 BP 505 EP 512 DI 10.1097/JOM.0b013e3181d6c338 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 595KC UT WOS:000277608100010 PM 20431418 ER PT J AU Larson, TC Antao, VC Bove, FJ AF Larson, Theodore C. Antao, Vinicius C. Bove, Frank J. TI Vermiculite Worker Mortality: Estimated Effects of Occupational Exposure to Libby Amphibole SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID PARTICULATE AIR-POLLUTION; ISCHEMIC-HEART-DISEASE; LUNG-CANCER; TREMOLITE ACTINOLITE; RISK-FACTORS; ASBESTOS; MONTANA; MINERS; COHORT; SMOKING AB Objective: To examine the relationship between cumulative fiber exposure (CFE) and mortality in a retrospective cohort study of vermiculite workers exposed to Libby amphibole (n = 1862). Methods: Extended Cox regression was used to estimate the hazards associated with CFE as a time-dependent covariate of multiple-cause mortality. Results: The Cox models for mesothelioma, asbestosis, lung cancer, and non-malignant respiratory disease were significant with rate ratios that increased monotonically with CFE. The model for deaths due to cardiovascular disease was also significant (rate ratio for CFE = >= 44.0 f/cc-y vs = 1.4 f/cc-y was 1.5; 95% confidence interval = 1.1 to 2.0). Conclusions: By using a within-cohort comparison, the results demonstrate a clear exposure-response relationship between CFE and mortality from asbestos-related causes. The finding of an association between CFE and cardiovascular mortality suggests persons exposed to Libby amphibole should be monitored for this outcome. C1 [Larson, Theodore C.; Antao, Vinicius C.; Bove, Frank J.] ATSDR, DHS, Atlanta, GA 30341 USA. RP Larson, TC (reprint author), ATSDR, DHS, 4770 Buford Highway NE,MS F57, Atlanta, GA 30341 USA. EM thl3@cdc.gov RI Antao, Vinicius/B-5395-2013 OI Antao, Vinicius/0000-0002-8201-9973 NR 34 TC 16 Z9 17 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2010 VL 52 IS 5 BP 555 EP 560 DI 10.1097/JOM.0b013e3181dc6d45 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 595KC UT WOS:000277608100017 PM 20431408 ER PT J AU Hallal, PC Simoes, E Reichert, FF Azevedo, MR Ramos, LR Pratt, M Brownson, RC AF Hallal, Pedro C. Simoes, Eduardo Reichert, Felipe F. Azevedo, Mario R. Ramos, Luiz R. Pratt, Michael Brownson, Ross C. TI Validity and Reliability of the Telephone-Administered International Physical Activity Questionnaire in Brazil SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE accelerometry; measurement; physical activity; exercise; physical activity assessment ID EPIDEMIOLOGIC RESEARCH; INACTIVITY; AGREEMENT; ADULTS; IPAQ AB Purpose: To evaluate the validity and reliability of the telephone-administered long IPAQ version. Methods: The questionnaire was administered by telephone to adults on days 1 and 6. On day 1, the same questionnaire was administered by face-to-face interview, and accelerometers were delivered to subjects. Reliability was measured by comparing data collected using the telephone questionnaire on days 1 and 6. Validity was measured by comparing the telephone questionnaire data with (a) face-to-face questionnaire and (b) accelerometry. Results: Data from all instruments were available for 156 individuals. The Spearman correlation coefficient for telephone interview reliability was 0.92 for the leisure-time section of IPAQ, and 0.87 for the transport-related section of IPAQ. The telephone interview reliability kappa was 0.78. The Spearman correlation between the telephone-administered and the face-to-face questionnaire was 0.94 for the leisure-time and 0.82 for the transport-related section. The kappa was 0.69. There was a positive association between quartiles of accelerometer data and total telephone-administered IPAQ score (P < .001). The Spearman correlation was 0.22. Conclusions: The telephone-administered IPAQ presented almost perfect reliability and very high agreement with the face-to-face version. The agreement with accelerometer data were fair for the continuous score, but moderate for the categorical physical activity variables. C1 [Hallal, Pedro C.; Azevedo, Mario R.] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil. [Simoes, Eduardo; Pratt, Michael] Ctr Dis Control & Prevent, Atlanta, GA USA. [Reichert, Felipe F.] Univ Estadual Londrina, Londrina, Parana, Brazil. [Ramos, Luiz R.] Univ Fed Sao Paulo, Sao Paulo, Brazil. [Brownson, Ross C.] Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO USA. [Brownson, Ross C.] Washington Univ, Dept Surg, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, St Louis, MO USA. RP Hallal, PC (reprint author), Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil. RI Ramos, Luiz/E-5343-2012; Hallal, Pedro/A-3249-2011; Reichert, Felipe/E-4899-2012; Epidemiologicas, Centro de pesquisas /D-4561-2013; OI Hallal, Pedro/0000-0003-1470-6461; Reichert, Felipe/0000-0002-0951-9875; Simoes, Eduardo/0000-0003-4371-4305 FU NCCDPHP CDC HHS [U48/DP000060-01] NR 17 TC 27 Z9 28 U1 0 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD MAY PY 2010 VL 7 IS 3 BP 402 EP 409 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 636LV UT WOS:000280738100015 PM 20551498 ER PT J AU Guh, A Heyman, ML Barden, D Fontana, J Hadler, JL AF Guh, Alice Heyman, Marian L. Barden, Diane Fontana, John Hadler, James L. TI Lessons Learned From the Investigation of a Cluster of Cutaneous Anthrax Cases in Connecticut SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE anthrax; Bacillus anthracis; environmental remediation; occupational diseases ID BIOTERRORISM; UPDATE AB In 2007, two cases of cutaneous anthrax associated with West African drum making were reported in Connecticut in a drum-maker and his child. Although both cases were due to exposure to naturally occurring Bacillus anthracis from imported animal hides, ensuing investigative and remediation efforts were affected by the intentional B anthracis attacks in 2001. To share our experience of responding to an outbreak of anthrax in the biologic terrorism preparedness era, we summarize Connecticut's investigation and describe lessons learned. Laboratory capacity to rapidly assist in diagnosing anthrax, collaborative associations between epidemiologists and law enforcement personnel, and training in use of the Incident Command System, all these a result of public health preparedness, enhanced the initial recognition and subsequent investigation of these anthrax cases. However, without established guidelines for environmental risk assessment and remediation of private residences contaminated by B anthracis, challenges were encountered that resulted in a conservative and expensive approach to remediation. Without a more rigorous approach to ensuring that B anthracis spore-free hides are used, the making of animal hide drums is likely to pose a continuing risk for anthrax to those working with contaminated hides and those exposed to subsequently contaminated environments. C1 [Guh, Alice] Ctr Dis Control & Prevent, Prevent & Response Branch, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Heyman, Marian L.] Connecticut State Dept Publ Hlth, Indoor Environm Qual Unit, Hartford, CT USA. [Heyman, Marian L.] Connecticut State Dept Publ Hlth, Environm & Occupat Hlth Assessment Program, Hartford, CT USA. [Fontana, John] Connecticut Dept Publ Hlth Lab, Hartford, CT USA. [Hadler, James L.] Connecticut Dept Publ Hlth, Infect Dis Sect, Hartford, CT USA. RP Guh, A (reprint author), Ctr Dis Control & Prevent, Prevent & Response Branch, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-31, Atlanta, GA 30333 USA. EM aguh@cdc.gov NR 29 TC 11 Z9 11 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAY-JUN PY 2010 VL 16 IS 3 BP 201 EP 210 DI 10.1097/PHH.0b013e3181ca650d PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 586AS UT WOS:000276873700003 PM 20357605 ER PT J AU Holtgrave, DR AF Holtgrave, David R. TI Public Health Errors: Costing Lives, Millions at a Time SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material ID CARE C1 [Holtgrave, David R.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD 21205 USA. [Holtgrave, David R.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Holtgrave, David R.] US Ctr Dis Control & Prevent, Div HIV AIDS Prevent Intervent Res & Support, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA. RP Holtgrave, DR (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 624 N Broadway,Ste 280, Baltimore, MD 21205 USA. EM dholtgrave@jhsph.edu NR 19 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAY-JUN PY 2010 VL 16 IS 3 BP 211 EP 215 DI 10.1097/PHH.0b013e3181bee698 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 586AS UT WOS:000276873700004 PM 20357606 ER PT J AU Woodhouse, LD Auld, ME Miner, K Alley, KB Lysoby, L Livingood, WC AF Woodhouse, Lynn D. Auld, M. Elaine Miner, Kathleen Alley, Kelly Bishop Lysoby, Linda Livingood, William C. TI Crosswalking Public Health and Health Education Competencies: Implications for Professional Preparation and Practice SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE certification; competencies; credentialing; employers; health education; health promotion; professional preparation; public health; workforce development AB This article highlights similarities and differences between the public health competencies recently developed by the Association of Schools of Public Health (ASPH) and one public health specialty, health education (HE), which has used competencies in its quality assurance systems for more than 20 years. Based on a crosswalk methodology developed for this analysis, some 50 percent to 61 percent of the HE and ASPH competencies had similarities of varying degrees; 18 percent were deemed matches due to sameness in skill or content. Most similarities were found between the ASPH social and behavioral sciences competencies and the HE competencies. Significant domains of "no match" were found between the HE and ASPH competencies in the areas of Systems Thinking, Leadership, and Public Health Biology. The study results have implications for academic programs related to curricula review and revision, continuing education providers who are developing training agendas for the workforce, employers anticipating competencies in new job hires, and prospective students and practitioners who are considering a form of certification. Qualitative insights from the study related to professional culture, purpose, age, and consistency of the scope or depth of the two competency sets, as well as the crosswalk methodology itself, may be useful to those comparing other competency sets. C1 [Woodhouse, Lynn D.] Georgia So Coll, Jiann Ping Hsu Coll Publ Hlth, Statesboro, GA 30460 USA. [Auld, M. Elaine] Soc Publ Hlth Educ, Washington, DC USA. [Miner, Kathleen] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Alley, Kelly Bishop] Ctr Dis Control & Prevent, Div Adolescent, Atlanta, GA USA. [Alley, Kelly Bishop] Ctr Dis Control & Prevent, Sch Hlth, Atlanta, GA USA. [Lysoby, Linda] Natl Commiss Hlth Educ Credentialing Inc, Whitehall, PA USA. [Livingood, William C.] Inst Hlth Policy & Evaluat Res, Duval Cty Hlth Dept, Jacksonville, FL USA. [Livingood, William C.] Univ Florida, Coll Med Jacksonville, Dept Pediat, Gainesville, FL 32611 USA. RP Woodhouse, LD (reprint author), Georgia So Coll, Jiann Ping Hsu Coll Publ Hlth, POB 8015,Cone Hall, Statesboro, GA 30460 USA. EM lwoodhouse@georgiasouthern.edu NR 39 TC 6 Z9 6 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAY-JUN PY 2010 VL 16 IS 3 BP E20 EP E28 DI 10.1097/PHH.0b013e3181b3a3d2 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 586AS UT WOS:000276873700015 PM 20357601 ER PT J AU Keckler, MS Gallardo-Romero, NF Langham, GL Damon, IK Karem, KL Carroll, DS AF Keckler, M. Shannon Gallardo-Romero, Nadia F. Langham, Gregory L. Damon, Inger K. Karem, Kevin L. Carroll, Darin S. TI Physiologic Reference Ranges for Captive Black-Tailed Prairie Dogs (Cynomys ludovicianus) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID BODY-TEMPERATURE PATTERNS; FLEAS SIPHONAPTERA; GROUND-SQUIRRELS; SERUM CHEMISTRY; GOLDEN-HAMSTERS; ANIMAL-MODEL; HIBERNATION; BARTONELLA; CERATOPHYLLIDAE; RICKETTSIA AB The black-tailed prairie dog (Cynomys ludovicianus) is a member of the order Rodentia and the family Sciuridae. Ecologically, prairie dogs are a keystone species in prairie ecology. This species is used as an animal model for human gallbladder disease and diseases caused by infection with Clostridium difficile, Yersinia pestis, Francisella tularensis, and most recently, Orthopoxvirus. Despite increasing numbers of prairie dogs used in research and kept as pets, few data are available on their baseline physiology in animal facility housing conditions. To establish baseline physiologic reference ranges, we designed a study using 18 wild-caught black-tailed prairie dogs. Telemetry data were analyzed to establish circadian rhythms for activity and temperature. In addition, hematologic and serum chemistry analyses were performed. Baseline measurements were used to establish the mean for each animal, which then were compiled and analyzed to determine the reference ranges. Here we present physiologic data on serum chemistry and hematology profiles, as well as weight, core body temperature, and daily activity patterns for black-tailed prairie dogs. These results reflect the use of multiple measurements from species- and age-matched prairie dogs and likely will be useful to ecologists, scientists interested in using this animal model in research, and veterinarians caring for pet prairie dogs. C1 [Keckler, M. Shannon; Gallardo-Romero, Nadia F.; Damon, Inger K.; Karem, Kevin L.; Carroll, Darin S.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. [Langham, Gregory L.] Ctr Dis Control & Prevent, Div Sci Resources, Anim Resources Branch, Lawrenceville, GA USA. RP Keckler, MS (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. EM hbq0@cdc.gov RI Keckler, M Shannon/C-3864-2009 NR 55 TC 9 Z9 9 U1 1 U2 12 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAY PY 2010 VL 49 IS 3 BP 274 EP 281 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 599FA UT WOS:000277895200005 PM 20587156 ER PT J AU Rethman, MP Carpenter, W Cohen, EEW Epstein, J Evans, CA Flaitz, CM Graham, FJ Hujoel, PP Kalmar, JR Koch, WM Lambert, PM Lingen, MW Oettmeier, BW Patton, LL Perkins, D Reid, BC Sciubba, JJ Tomar, SL Wyatt, AD Aravamudhan, K Frantsve-Hawley, J Cleveland, JL Meyer, DM AF Rethman, Michael P. Carpenter, William Cohen, Ezra E. W. Epstein, Joel Evans, Caswell A. Flaitz, Catherine M. Graham, Frank J. Hujoel, Philippe P. Kalmar, John R. Koch, Wayne M. Lambert, Paul M. Lingen, Mark W. Oettmeier, Bert W., Jr. Patton, Lauren L. Perkins, David Reid, Britt C. Sciubba, James J. Tomar, Scott L. Wyatt, Alfred D., Jr. Aravamudhan, Krishna Frantsve-Hawley, Julie Cleveland, Jennifer L. Meyer, Daniel M. CA Amer Dent Assoc Council Sci TI Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article DE American Dental Association (ADA); biopsy; brush; cancer; carcinoma; squamous cell; evidence-based dentistry; mouth neoplasms; oral cancer; practice guidelines ID UPPER AERODIGESTIVE TRACT; HUMAN-PAPILLOMAVIRUS; TOLUIDINE BLUE; NECK-CANCER; HEAD; METAANALYSIS; LESIONS; CHEMILUMINESCENCE; DYSPLASIA; VISUALIZATION AB Background. This article presents evidence-based clinical recommendations developed by a panel convened by the American Dental Association Council on Scientific Affairs. This report addresses the potential benefits and potential risks of screening for oral squamous cell carcinomas and the use of adjunctive screening aids to visualize and detect potentially malignant and malignant oral lesions. Types of Studies Reviewed. The panel members conducted a systematic search of MEDLINE, identifying 332 systematic reviews and 1,499 recent clinical studies. They selected five systematic reviews and four clinical studies to use as a basis for developing recommendations. Results. The panel concluded that screening by means of visual and tactile examination to detect potentially malignant and malignant lesions may result in detection of oral cancers at early stages of development, but that there is insufficient evidence to determine if screening alters disease-specific mortality in asymptomatic people seeking dental care. Clinical Implications. The panel suggested that clinicians remain alert for signs of potentially malignant lesions or early-stage cancers while performing routine visual and tactile examinations in all patients, but particularly in those who use tobacco or who consume alcohol heavily. Additional research regarding oral cancer screening and the use of adjuncts is needed. C1 [Aravamudhan, Krishna; Frantsve-Hawley, Julie] Amer Dent Assoc, Ctr Evidence Based Dent, Div Sci, Chicago, IL 60611 USA. [Rethman, Michael P.] Univ Maryland, Baltimore Coll Dent Surg, Baltimore, MD USA. [Carpenter, William] Univ Pacific, Arthur A Dugoni Sch Dent, Dept Pathol & Med, San Francisco, CA USA. [Cohen, Ezra E. W.] Univ Chicago, Med Ctr, Dept Med, Chicago, IL 60637 USA. [Epstein, Joel] Univ Illinois, Coll Dent, Dept Oral Med & Diagnost Sci, Chicago, IL USA. [Epstein, Joel] Univ Illinois, Coll Med, Dept Otolaryngol Head & Neck Surg, Chicago, IL USA. [Epstein, Joel] Univ Illinois, Ctr Canc, Chicago, IL USA. [Flaitz, Catherine M.] Univ Texas Dent Branch, Dept Diagnost Sci, Houston, TX USA. [Flaitz, Catherine M.] Univ Texas Dent Branch, Dept Pediat Dent, Houston, TX USA. [Graham, Frank J.] Montefiore Med Ctr, Dept Dent, Bronx, NY 10467 USA. [Hujoel, Philippe P.] Univ Washington, Sch Dent, Dept Dent Publ Hlth Sci, Seattle, WA 98195 USA. [Koch, Wayne M.] Univ Maryland, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA. [Lambert, Paul M.] Dept Vet Affairs Med Ctr, Boise, ID USA. [Lingen, Mark W.] Univ Chicago, Med Ctr, Dept Pathol, Chicago, IL 60637 USA. [Patton, Lauren L.] Univ N Carolina, Sch Dent, Dept Dent Ecol, Chapel Hill, NC 27599 USA. [Reid, Britt C.] NCI, Modifiable Risk Factors Branch, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Sciubba, James J.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Tomar, Scott L.] Univ Florida, Coll Dent, Dept Community Dent & Behav Sci, Gainesville, FL USA. [Wyatt, Alfred D., Jr.] Med Coll Georgia, Sch Dent, Atlanta, GA USA. [Kalmar, John R.] Ohio State Univ, Coll Dent, Div Oral & Maxillofacial Surg Pathol & Anesthesio, Columbus, OH 43210 USA. [Frantsve-Hawley, Julie] Amer Dent Assoc, Res Inst, Chicago, IL 60611 USA. [Cleveland, Jennifer L.] Ctr Dis Control & Prevent, Surveillance Invest & Res Branch, Div Oral Hlth, Chamblee, GA USA. RP Aravamudhan, K (reprint author), Amer Dent Assoc, Ctr Evidence Based Dent, Div Sci, 211 E Chicago Ave, Chicago, IL 60611 USA. EM aravamudhank@ada.org OI Patton, Lauren/0000-0002-8253-4588 NR 51 TC 103 Z9 111 U1 1 U2 12 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD MAY PY 2010 VL 141 IS 5 BP 509 EP 520 PG 12 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 594KV UT WOS:000277537500017 PM 20436098 ER PT J AU Thompson, ND Barry, V Alelis, K Cui, DM Perz, JF AF Thompson, Nicola D. Barry, Vaughn Alelis, Karen Cui, Dongming Perz, Joseph F. TI Evaluation of the Potential for Bloodborne Pathogen Transmission Associated with Diabetes Care Practices in Nursing Homes and Assisted Living Facilities, Pinellas County SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE long-term care; hepatitis B virus; blood glucose monitoring; diabetes; infection control ID HEPATITIS-B-VIRUS; NOSOCOMIAL TRANSMISSION; UNITED-STATES; VACCINATION; INFECTION; WORKERS AB OBJECTIVES To evaluate and characterize routine blood glucose monitoring practices in nursing homes and assisted living facilities (ALFs). DESIGN Cross-sectional, self administered survey and facility site visit. SETTING Two hundred eighty-nine licensed long-term care facilities in Pinellas County, Florida. PARTICIPANTS Stratified random sample of 48 long-term care facilities (17% overall sample). MEASUREMENTS Data on facility characteristics, infection control policies, staff practices, and equipment used for blood glucose monitoring. Differences between facilities in each stratum were compared and evaluated using the Pearson chi-square or Fisher exact test. RESULTS Fifteen nursing homes and 17 small and 16 large ALFs participated; 53 declined (48% participation rate). Bloodborne pathogen training (P=.02), hepatitis B vaccination (P=.003), and blood glucose monitoring (P <.001) policies were reported less often at ALFs. Staff glove use during blood glucose monitoring was lowest (50%) at small ALFs (P=.02). Reusable fingerstick devices intended for personal use were most often in use at ALFs (P <.001); four of 18 facilities (including 1 nursing home) were inappropriately using them for multiple residents. At 22 facilities (including all nursing homes), multiple residents shared blood glucose meters; only six (27%) reported cleaning them after each use. CONCLUSION Despite existing recommendations, practices that facilitate bloodborne pathogen transmission during blood glucose monitoring were identified at nursing homes and ALFs. Infection control practices and polices were most often lacking at ALFs. Better training and oversight of blood glucose monitoring in long-term care is needed to prevent transmission of bloodborne pathogens. C1 [Thompson, Nicola D.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Thompson, Nicola D.; Barry, Vaughn; Cui, Dongming] Ctr Dis Control & Prevent, Div Viral Hepatitis, Epidemiol & Surveillance Branch, Atlanta, GA USA. [Perz, Joseph F.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Prevent & Response Branch, Atlanta, GA USA. [Alelis, Karen] Florida Dept Hlth, Florida Epidem Intelligence Serv, Tallahassee, FL USA. [Alelis, Karen; Cui, Dongming] Pinellas Cty Hlth Dept, Program Epidemiol, St Petersburg, FL USA. RP Thompson, ND (reprint author), 1600 Clifton Rd,MS G-37, Atlanta, GA 30333 USA. EM ndthompson@cdc.gov NR 24 TC 7 Z9 7 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD MAY PY 2010 VL 58 IS 5 BP 914 EP 918 DI 10.1111/j.1532-5415.2010.02802.x PG 5 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 592XE UT WOS:000277414400017 PM 20374398 ER PT J AU Deas, C McCree, DH AF Deas, Crystal McCree, Donna Hubbard TI Pharmacists and HIV/AIDS prevention: Review of the literature SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION LA English DT Article DE Pharmacists; pharmacy practice; human immunodeficiency virus; disease prevention ID UNITED-STATES; HIV; AIDS AB Objectives: To provide a summary of the available literature on pharmacists' participation in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) prevention efforts, excluding needle exchange programs or highly active antiretroviral therapy (HAART) education, and to offer strategies based on the literature to expand pharmacists' roles in HIV/AIDS prevention efforts. Data sources: Data were collected from published reports indexed from database inception through December 2008 and identified through the Centers for Disease Control and Prevention's Prevention Research Synthesis database, Ovid, PubMed, Embase, and Cochrane Library. Search terms used were pharmacist or pharmacy and HIV and/or prevention or counseling or testing or screening. Study selection: Only English language reports were included; studies that focused on needle/syringe exchange programs and HAART therapy education and adherence counseling were excluded. Data synthesis: 13 reports were identified. The majority of articles were from international sources, and all focused on pharmacists and pharmacies as HIV/AIDS information resources. Conclusion: Findings from the available literature showed that most pharmacists served in treatment and prevention information resource roles but were interested in expanding their roles into other prevention efforts, including HIV testing with additional training. Pharmacists described in the reports expressed a need for specific training regarding HIV/AIDS knowledge and transmission. C1 [McCree, Donna Hubbard] Ctr Dis Control, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP McCree, DH (reprint author), Ctr Dis Control, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd NE,MS E-37, Atlanta, GA 30333 USA. EM zyr1@cdc.gov NR 18 TC 11 Z9 11 U1 0 U2 5 PU AMER PHARMACEUTICAL ASSOC PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 USA SN 1544-3191 J9 J AM PHARM ASSOC JI J. Am. Pharm. Assoc. PD MAY-JUN PY 2010 VL 50 IS 3 BP 411 EP 415 DI 10.1331/JAPhA.2010.09039 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 598AB UT WOS:000277802800015 PM 20452917 ER PT J AU Arguin, PM AF Arguin, Paul M. TI A Definition That Includes First and Second Generation Immigrants Returning to Their Countries of Origin to Visit Friends and Relatives Still Makes Sense to Me SO JOURNAL OF TRAVEL MEDICINE LA English DT Editorial Material ID IMPORTED MALARIA; TRAVELERS; RISK; ETHNICITY; AFRICA C1 [Arguin, Paul M.] Ctr Dis Control & Prevent, Domest Malaria Unit, Atlanta, GA 30341 USA. RP Arguin, PM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Malaria Branch, Domest Unit, 4770 Buford Highway NE,MS F-22, Atlanta, GA 30341 USA. EM parguin@cdc.gov NR 21 TC 4 Z9 4 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD MAY-JUN PY 2010 VL 17 IS 3 BP 147 EP 149 DI 10.1111/j.1708-8305.2010.00412.x PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 586TB UT WOS:000276935000001 PM 20536881 ER PT J AU Haley, AC Platt, SR Kent, M Miller, AD Barber, R Li, Q Tong, S Schatzberg, SJ AF Haley, A. C. Platt, S. R. Kent, M. Miller, A. D. Barber, R. Li, Q. Tong, S. Schatzberg, S. J. TI INVESTIGATION OF CANINE PRIMARY BRAIN TUMORS FOR THE PRESENCE OF DNA FROM HERPES- AND POLYOMAVIRUSES BY BROADLY REACTIVE PAN-VIRAL PCR (99 CASES) SO JOURNAL OF VETERINARY INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Haley, A. C.; Platt, S. R.; Kent, M.; Barber, R.; Li, Q.; Schatzberg, S. J.] Univ Georgia, Coll Vet Med, Athens, GA 30602 USA. [Miller, A. D.] Harvard Univ, Sch Med, Div Comparat Pathol, Southborough, MA 01772 USA. [Tong, S.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0891-6640 J9 J VET INTERN MED JI J. Vet. Intern. Med. PD MAY-JUN PY 2010 VL 24 IS 3 MA 87 BP 697 EP 697 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA 592XZ UT WOS:000277416600121 ER PT J AU Burton, AJ Nydam, DV Mitchell, K Dearen, TK Bowman, DD Xiao, L AF Burton, A. J. Nydam, D. V. Mitchell, K. Dearen, T. K. Bowman, D. D. Xiao, L. TI THE MOLECULAR EPIDEMIOLOGY OF GIARDIA SHEDDING IN HORSES AND ALPACAS IN NEW YORK STATE SO JOURNAL OF VETERINARY INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Burton, A. J.; Nydam, D. V.; Mitchell, K.; Bowman, D. D.] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA. [Dearen, T. K.; Xiao, L.] CDC, Div Parasit Dis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0891-6640 J9 J VET INTERN MED JI J. Vet. Intern. Med. PD MAY-JUN PY 2010 VL 24 IS 3 MA 368 BP 783 EP 783 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA 592XZ UT WOS:000277416600402 ER PT J AU Burton, AJ Nydam, DV Mitchell, K Dearen, TK Bowman, DD Xiao, L AF Burton, A. J. Nydam, D. V. Mitchell, K. Dearen, T. K. Bowman, D. D. Xiao, L. TI IDENTIFICATION OF THE CRYPTOSPORIDIUM HORSE GENOTYPE FROM FOALS IN NEW YORK STATE SO JOURNAL OF VETERINARY INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Burton, A. J.; Nydam, D. V.; Mitchell, K.; Bowman, D. D.] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA. [Dearen, T. K.; Xiao, L.] CDC, Div Parasit Dis, Atlanta, GA 30333 USA. RI Mitchell, Katharyn/G-7915-2016 OI Mitchell, Katharyn/0000-0002-5545-5630 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0891-6640 J9 J VET INTERN MED JI J. Vet. Intern. Med. PD MAY-JUN PY 2010 VL 24 IS 3 MA 369 BP 783 EP 783 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA 592XZ UT WOS:000277416600403 ER PT J AU Belser, JA Wadford, DA Pappas, C Gustin, KM Maines, TR Pearce, MB Zeng, H Swayne, DE Pantin-Jackwood, M Katz, JM Tumpey, TM AF Belser, Jessica A. Wadford, Debra A. Pappas, Claudia Gustin, Kortney M. Maines, Taronna R. Pearce, Melissa B. Zeng, Hui Swayne, David E. Pantin-Jackwood, Mary Katz, Jacqueline M. Tumpey, Terrence M. TI Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice SO JOURNAL OF VIROLOGY LA English DT Article ID BRONCHIAL EPITHELIAL-CELLS; BIRD FLU INFECTION; H5N1 VIRUSES; CYTOKINE RESPONSES; ENHANCED VIRULENCE; HONG-KONG; FORT-DIX; HUMANS; FERRETS; TRANSMISSION AB The pandemic H1N1 virus of 2009 (2009 H1N1) continues to cause illness worldwide, primarily in younger age groups. To better understand the pathogenesis of these viruses in mammals, we used a mouse model to evaluate the relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple-reassortant swine influenza virus that has circulated in pigs in the United States for over a decade preceding the current pandemic. Additional comparisons were made with the reconstructed 1918 virus, a 1976 H1N1 swine influenza virus, and a highly pathogenic H5N1 virus. Mice were inoculated intranasally with each virus and monitored for morbidity, mortality, viral replication, hemostatic parameters, cytokine production, and lung histology. All 2009 H1N1 viruses replicated efficiently in the lungs of mice and possessed a high degree of infectivity but did not cause lethal disease or exhibit extrapulmonary virus spread. Transient weight loss, lymphopenia, and proinflammatory cytokine and chemokine production were present following 2009 H1N1 virus infection, but these levels were generally muted compared with a triple-reassortant swine virus and the 1918 virus. 2009 H1N1 viruses isolated from fatal cases did not demonstrate enhanced virulence in this model compared with isolates from mild human cases. Histologically, infection with the 2009 viruses resulted in lesions in the lung varying from mild to moderate bronchiolitis with occasional necrosis of bronchiolar epithelium and mild to moderate peribronchiolar alveolitis. Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses. C1 [Belser, Jessica A.; Wadford, Debra A.; Pappas, Claudia; Gustin, Kortney M.; Maines, Taronna R.; Pearce, Melissa B.; Zeng, Hui; Katz, Jacqueline M.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Swayne, David E.; Pantin-Jackwood, Mary] ARS, Exot & Emerging Avian Viral Dis Res Unit, SE Poultry Res Lab, USDA, Athens, GA 30605 USA. RP Tumpey, TM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, MS G-16,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM tft9@cdc.gov NR 46 TC 74 Z9 74 U1 3 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2010 VL 84 IS 9 BP 4194 EP 4203 DI 10.1128/JVI.02742-09 PG 10 WC Virology SC Virology GA 579GW UT WOS:000276358000008 PM 20181710 ER PT J AU Hai, R Schmolke, M Varga, ZT Manicassamy, B Wang, TT Belser, JA Pearce, MB Garcia-Sastre, A Tumpey, TM Palese, P AF Hai, Rong Schmolke, Mirco Varga, Zsuzsanna T. Manicassamy, Balaji Wang, Taia T. Belser, Jessica A. Pearce, Melissa B. Garcia-Sastre, Adolfo Tumpey, Terrence M. Palese, Peter TI PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models SO JOURNAL OF VIROLOGY LA English DT Article ID A VIRUS; MITOCHONDRIAL PROTEIN; PATHOGENESIS; FERRETS; MICE; PNEUMONIA; TRANSMISSION; CONTRIBUTES; INFECTION AB Unlike previous pandemic viruses, the 2009 H1N1 pandemic influenza virus does not code for the virulence factor PB1-F2. The genome of the 2009 H1N1 virus contains three stop codons preventing PB1-F2 expression; however, PB1-F2 production could occur following genetic mutation or reassortment. Thus, it is of great interest to understand the impact that expression of the PB1-F2 protein might have in the context of the 2009 pandemic influenza virus, A/California/04/2009 (Cal/09). We have addressed this question by generating two Cal/09 viruses with productive PB1-F2 open reading frames containing either an asparagine at position 66 of PB1-F2 (66N) or a serine at position 66 (66S): this N66S change has previously been shown to be associated with increased virulence in mice. We used these viruses to investigate the effect on virulence conferred by expression of the 66N or the 66S PB1-F2 protein in both in vitro and in vivo systems. Our results show enhanced replication of the 66S virus in A549 cells, while studies of BALB/c and DBA/2 mice and ferrets revealed no significant differences in symptoms of infection with wild-type Cal/09 versus the 66N or 66S virus variant. Also, coinfection of mice with Streptococcus pneumoniae and the different viruses (recombinant wild-type [rWT] Cal/09 and the 66N and 66S viruses) did not result in significant differences in mortality. Mice infected with either PB1-F2-expressing virus did demonstrate altered protein levels of proinflammatory cytokines; differences were observed to be greater in infection caused by the 66S virus. In summary, our study demonstrates that PB1-F2 expression by the Cal/09 virus modulates the immune response to infection while having a minimal effect on virus virulence in two mammalian models. C1 [Hai, Rong; Schmolke, Mirco; Varga, Zsuzsanna T.; Manicassamy, Balaji; Wang, Taia T.; Garcia-Sastre, Adolfo; Palese, Peter] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Inst Global Hlth & Emerging Pathogens, New York, NY 10029 USA. [Garcia-Sastre, Adolfo; Palese, Peter] Mt Sinai Sch Med, Div Infect Dis, Dept Med, New York, NY 10029 USA. [Belser, Jessica A.; Pearce, Melissa B.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, CCID,NCIRD, Atlanta, GA USA. RP Palese, P (reprint author), Mt Sinai Sch Med, Dept Microbiol, 1 Gustave Levy Pl, New York, NY 10029 USA. EM peter.palese@mssm.edu OI Palese, Peter/0000-0002-0337-5823; Garcia-Sastre, Adolfo/0000-0002-6551-1827 FU CRIP, NIAID [HHSN266200700010C]; NIH [P01 AI 058113, U19 AI62623, T32 AI007647]; Mount Sinai Medical Scientists Training [T32 GM007280] FX This work was supported by CRIP (Center for Research on Influenza Pathogenesis, NIAID contract HHSN266200700010C) and by grants P01 AI 058113 and U19 AI62623 (Center for Investigating Viral Immunity and Antagonism) from the NIH. T. T. W. was supported by NIH training grant T32 AI007647 and Mount Sinai Medical Scientists Training Grant T32 GM007280. NR 29 TC 88 Z9 90 U1 2 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2010 VL 84 IS 9 BP 4442 EP 4450 DI 10.1128/JVI.02717-09 PG 9 WC Virology SC Virology GA 579GW UT WOS:000276358000030 PM 20181699 ER PT J AU Brown-Bryant, R Brumbaugh, K AF Brown-Bryant, Renee Brumbaugh, Kelly TI A Perspective on CDC's Efforts in Safe Motherhood: 2001 to the Present SO JOURNAL OF WOMENS HEALTH LA English DT Article ID PREGNANCY-RELATED MORTALITY; UNITED-STATES; HEALTH-CARE; WOMEN AB This article reviews selected activities to promote Safe Motherhood through scientific and programmatic activities conducted by CDC's Division of Reproductive Health. C1 [Brown-Bryant, Renee; Brumbaugh, Kelly] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Brown-Bryant, R (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,MSK 20, Atlanta, GA 30341 USA. EM crb0@cdc.gov NR 21 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD MAY PY 2010 VL 19 IS 5 BP 833 EP 836 DI 10.1089/jwh.2010.2049 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 595HW UT WOS:000277602300001 PM 20384454 ER PT J AU Kaminski, JW Puddy, RW Hall, DM Cashman, SY Crosby, AE Ortega, LAG AF Kaminski, Jennifer W. Puddy, Richard W. Hall, Diane M. Cashman, Sandra Y. Crosby, Alexander E. Ortega, LaVonne A. G. TI The Relative Influence of Different Domains of Social Connectedness on Self-Directed Violence in Adolescence SO JOURNAL OF YOUTH AND ADOLESCENCE LA English DT Article DE Adolescents; Suicide; Family relations; Peer relations; School connectedness ID PROTECTIVE-FACTORS; SUICIDE ATTEMPTS; RISK; YOUTH; BEHAVIORS; HEALTH AB Previous research has linked greater social connectedness with a lowered risk of self-directed violence among adolescents. However, few studies have analyzed the comparative strength of different domains of connectedness (e.g., family, peers and school) to determine where limited resources might best be focused. Data to address that gap were taken from the Centers for Disease Control and Prevention's Student Health and Safety Survey, administered to 4,131 7th-12th graders (51.5% female; 43.8% Hispanic; 22.6% African American or Black). Logistic regressions (controlling for age, gender, race/ethnicity, family structure, academic performance, and depressive symptoms) suggest that family connectedness was a stronger predictor than connectedness to peers, school, or adults at school for non-suicidal self-harm, suicidal ideation, suicide plans, and non-fatal suicidal behavior. In some analyses, peer connectedness was unexpectedly a risk factor. Results have implications for prevention of suicide in adolescence, especially in the context of the current trend towards school-based prevention programs. C1 [Kaminski, Jennifer W.; Puddy, Richard W.; Hall, Diane M.; Cashman, Sandra Y.; Crosby, Alexander E.; Ortega, LaVonne A. G.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Kaminski, JW (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Hwy NE,MS-F63, Atlanta, GA 30341 USA. EM JKaminski@cdc.gov; RPuddy@cdc.gov; DMHall@cdc.gov; SCashman@cdc.gov; AEC1@cdc.gov; LOrtega1@cdc.gov NR 21 TC 27 Z9 27 U1 0 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0047-2891 J9 J YOUTH ADOLESCENCE JI J. Youth Adolesc. PD MAY PY 2010 VL 39 IS 5 BP 460 EP 473 DI 10.1007/s10964-009-9472-2 PG 14 WC Psychology, Developmental SC Psychology GA 580FK UT WOS:000276432600003 PM 19898780 ER PT J AU Nair, H Nokes, DJ Gessner, BD Dherani, M Madhi, SA Singleton, RJ O'Brien, KL Roca, A Wright, PF Bruce, N Chandran, A Theodoratou, E Sutanto, A Sedyaningsih, ER Ngama, M Munywoki, PK Kartasasmita, C Simoes, EAF Rudan, I Weber, MW Campbell, H AF Nair, Harish Nokes, D. James Gessner, Bradford D. Dherani, Mukesh Madhi, Shabir A. Singleton, Rosalyn J. O'Brien, Katherine L. Roca, Anna Wright, Peter F. Bruce, Nigel Chandran, Aruna Theodoratou, Evropi Sutanto, Agustinus Sedyaningsih, Endang R. Ngama, Mwanajuma Munywoki, Patrick K. Kartasasmita, Cissy Simoes, Eric A. F. Rudan, Igor Weber, Martin W. Campbell, Harry TI Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis SO LANCET LA English DT Article ID HUMAN METAPNEUMOVIRUS; TRACT INFECTIONS; CHILDHOOD PNEUMONIA; INFLUENZA-VIRUS; DISEASE; RSV; AGE; EPIDEMIOLOGY; POPULATION; INFANTS AB Background The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. Methods We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. Findings In 2005, an estimated 33.8 (95% CI 19.3-46-2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Interpretation Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. C1 [Campbell, Harry] Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Global Hlth Acad, Edinburgh EH8 9AG, Midlothian, Scotland. [Nair, Harish] Publ Hlth Fdn India, New Delhi, India. [Nokes, D. James; Ngama, Mwanajuma; Munywoki, Patrick K.] Ctr Geog Med Res Coast, KEMRI, Kilifi, Kenya. [Nokes, D. James] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England. [Gessner, Bradford D.] Agence Med Prevent, Paris, France. [Dherani, Mukesh; Bruce, Nigel] Univ Liverpool, Div Publ Hlth, Liverpool L69 3BX, Merseyside, England. [Madhi, Shabir A.] Univ Witwatersrand, MRC, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Madhi, Shabir A.] Univ Witwatersrand, Dept Sci & Technol, Natl Res Fdn Vaccine Preventable Dis, Johannesburg, South Africa. [Singleton, Rosalyn J.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Singleton, Rosalyn J.] CDC, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA. [O'Brien, Katherine L.; Chandran, Aruna] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA. [Roca, Anna] Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain. [Roca, Anna] Minist Saude, CISM, Maputo, Mozambique. [Wright, Peter F.] Dartmouth Med Sch, Div Infect Dis & Int Hlth, Lebanon, NH USA. [Sutanto, Agustinus] W Nusa Tenggara Prov Govt, Lombok, Indonesia. [Sedyaningsih, Endang R.] Indonesian Minist Hlth, Jakarta, Indonesia. [Kartasasmita, Cissy] Padjadjaran State Univ, Hasan Sadikin Gen Hosp, Fac Med, Bandung, Indonesia. [Simoes, Eric A. F.] Univ Colorado, Denver, CO 80202 USA. [Simoes, Eric A. F.] Childrens Hosp, Denver, CO 80218 USA. [Rudan, Igor] Univ Split, Fac Med, Croatian Ctr Global Hlth, Split, Croatia. [Weber, Martin W.] WHO, Indonesia Country Off, Jakarta, Indonesia. RP Campbell, H (reprint author), Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Global Hlth Acad, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland. EM Harry.Campbell@ed.ac.uk RI Theodoratou, Evropi/C-3430-2014; Nair, Harish/E-7431-2010; Rudan, Igor/I-1467-2012 OI Theodoratou, Evropi/0000-0001-5887-9132; Nair, Harish/0000-0002-9432-9100; Rudan, Igor/0000-0001-6993-6884 FU WHO CAH [WHO OD/AP-07-04680]; Bill & Melinda Gates Foundation [R41202]; Wellcome Trust [061584, 076278]; Spanish Ministry of Education and Science (Ramon y Cajal) [RYC-2008-02777] FX This work was done as part of the wider programme of the Child Epidemiology Reference Group (CHERG) to establish the major causes of global childhood disease burden. We thank Emelda A Okiro, Ann Bett, John Abwao (KEMRI-Wellcome Trust Research Programme, Kenya); Dana Bruden (Arctic Investigations Program, National Center for Preparedness, Detection and Control of Infectious Disease, CDC, Anchorage, AK, USA); Byron Arana (Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala); Keith P Kingman (University of the Witwatersrand/Medical Research Council: Respiratory and Meningeal Pathogens Research Unit and Hubert Department of Global Health, Rollins School of Public Health and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA, USA); Pedro Alonso (Barcelona Centre for International Health Research (CRESIB), Hospital Clinic/IDIBAPS, Universitat de Barcelona, Spain and Centro de Investigacao em Saude da Manhica (CISM), Ministerio de Sande, Mozambique); Llorenc Quinto (Barcelona Centre for International Health Research (CRESIB), Hospital Clinic/IDIBAPS, Universitat de Barcelona, Spain); Kuswandewi Mutyara (Medical Faculty, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia); Lesley C McGoohan (Centre for Population Studies, Global Health Academy, The University of Edinburgh) assistance with some of the illustrations in this report; and Douglas Holtzman (Bill & Melinda Gates Foundation, Seattle, WA, USA) for participating in the expert group meeting in Edinburgh and reviewing the report. Financial support for this work was provided by WHO CAH (grant number WHO OD/AP-07-04680) and the Bill & Melinda Gates Foundation (R41202). Studies from Kilifi, Kenya received Wellcome Trust funding (061584, 076278). AR was supported by a grant from the Spanish Ministry of Education and Science (Ramon y Cajal: RYC-2008-02777). MWW is a WHO staff member; he is responsible for the views expressed in this publication and they do not necessarily represent the decisions or the policies of WHO. NR 56 TC 861 Z9 919 U1 13 U2 95 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD MAY 1 PY 2010 VL 375 IS 9725 BP 1545 EP 1555 DI 10.1016/S0140-6736(10)60206-1 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 596AH UT WOS:000277655100027 PM 20399493 ER PT J AU Korzeniewski, SJ Grigorescu, V Copeland, G Gu, G Thoburn, KK Rogers, JD Young, WI AF Korzeniewski, S. J. Grigorescu, V. Copeland, G. Gu, G. Thoburn, K. K. Rogers, J. D. Young, W. I. TI Methodological Innovations in Data Gathering: Newborn Screening Linkage with Live Births Records, Michigan, 1/2007-3/2008 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Newborn screening; Link Plus; Record linkage; Matching; Epidemiology AB Objective To match Michigan birth and newborn screening records to identify and follow-up potentially unscreened infants, assess data quality, and demonstrate the utility of Link Plus linkage software for matching MCH related administrative datasets. Methods Birth and newborn screening records maintained by the Michigan Department of Community Health from January 2007 through March 2008 were used in this study. Link Plus, a freely-available probabilistic record linkage software program developed at the Centers for Disease Control and Prevention, was used to match records. Linkage performance was assessed by the linkage success rate (percentage of valid matches). Follow-up of un-matched records was conducted by the Michigan Newborn Screening Follow-up Program. Results Nearly all (99.2%) of the 142,178 birth records included in this study were successfully matched to newborn screening records. Following a transition to a web-based electronic birth certificate system and inclusion of a newborn screening card identification number on the birth record in 2008, the linkage success rate increased to 99.6% based on analysis of approximately 18,000 records. Of approximately 600 un-matched records, nearly half had received a newborn screen. Approximately 8% of un-matched records were due to parental refusal of newborn screening. Nine children received an initial screen as a result of this study; one was confirmed as having sickle cell trait. Conclusions We have demonstrated that a freely available record linkage software, Link Plus, can be used to successfully match records of MCH databases thereby providing an opportunity for further research and quality assurance investigations. C1 [Korzeniewski, S. J.; Grigorescu, V.; Young, W. I.] Michigan Dept Community Hlth, Bur Epidemiol, Div Genom Perinatal Hlth & Chron Dis Epidemiol, Lansing, MI 48906 USA. [Copeland, G.] Michigan Dept Community Hlth, Div Vital Records & Hlth Stat, Lansing, MI 48906 USA. [Gu, G.] Sci Applicat Int Corp, San Diego, CA 92121 USA. [Thoburn, K. K.] Northrop Grumman, CDC NPCR Contractor, Los Angeles, CA USA. [Rogers, J. D.] Ctr Dis Control & Prevent, Natl Program Canc Registries, Atlanta, GA USA. RP Korzeniewski, SJ (reprint author), Michigan Dept Community Hlth, Bur Epidemiol, Div Genom Perinatal Hlth & Chron Dis Epidemiol, 201 Capital View 4-012, Lansing, MI 48906 USA. EM KorzeniewskiS@Michigan.gov NR 4 TC 13 Z9 13 U1 0 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAY PY 2010 VL 14 IS 3 BP 360 EP 364 DI 10.1007/s10995-009-0464-3 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 590RD UT WOS:000277244000006 PM 19353254 ER PT J AU Kim, SY England, L Dietz, PM Morrow, B Perham-Hester, KA AF Kim, Shin Y. England, Lucinda Dietz, Patricia M. Morrow, Brian Perham-Hester, Katherine A. TI Patterns of Cigarette and Smokeless Tobacco Use Before, During, and After Pregnancy Among Alaska Native and White Women in Alaska, 2000-2003 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Smokeless tobacco; Cigarette smoking; Pregnancy; Quit; Relapse ID MONITORING-SYSTEM PRAMS; SMOKING-CESSATION; UNITED-STATES; RELAPSE PREVENTION; RESPONSE RATES; POSTPARTUM; PREDICTORS; HEALTH; SNUFF; RISK AB Objective To examine patterns of cigarette and smokeless tobacco use before, during, and after pregnancy among Alaska Native (AN) and white women living in Alaska. Methods We used data from the 2000-2003 population-based Pregnancy Risk Assessment Monitoring System to describe patterns of self-reported prenatal tobacco use among AN and white women. We used multiple variable logistic regression analysis to identify maternal factors associated with quitting and relapse. The final sample included 5,458 women. Results During 2000-2003, the prevalence of any tobacco use before pregnancy was twofold higher among AN women than among white women (60.0 vs. 27.5%), and the prevalence of any tobacco use during pregnancy and after pregnancy were each nearly threefold higher. Of the 25.8% (SE 0.9) of white women who smoked before pregnancy, 49.0% (SE 2.1) reported that they quit during pregnancy and of those, 41.1% (SE 2.9) relapsed postpartum. Of the 38.5% (SE 0.9) of AN women who smoked before pregnancy, 35.7% (SE 1.4) quit, and of those 57.0% (SE 2.4) relapsed. Of the 14.2% of AN women who chewed tobacco before pregnancy, 15.7% (SE 1.7) quit, and of those, 52.9% (SE 5.9) relapsed. Conclusion During 2000-2003, the prevalence of tobacco use was two to three times higher among AN women than among white women before, during, and after pregnancy. In addition, AN women had lower quit rates and higher relapse rates than white women. Comprehensive, culturally appropriate tobacco control approaches targeting AN women are needed to increase cessation during pregnancy and to decrease relapse. C1 [Kim, Shin Y.; England, Lucinda; Dietz, Patricia M.; Morrow, Brian] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Perham-Hester, Katherine A.] Dept Hlth & Social Serv, Div Publ Hlth, Sect Womens Childrens & Family Hlth, Anchorage, AK USA. RP Kim, SY (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS K-23, Atlanta, GA 30341 USA. EM skim1@cdc.gov NR 31 TC 12 Z9 12 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAY PY 2010 VL 14 IS 3 BP 365 EP 372 DI 10.1007/s10995-009-0444-7 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 590RD UT WOS:000277244000007 PM 19139981 ER PT J AU Dott, M Rasmussen, SA Hogue, CJ Reefhuis, J AF Dott, Mary Rasmussen, Sonja A. Hogue, Carol J. Reefhuis, Jennita CA Natl Birth Defects Prevention Stud TI Association Between Pregnancy Intention and Reproductive-health Related Behaviors Before and After Pregnancy Recognition, National Birth Defects Prevention Study, 1997-2002 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Pregnancy; Unplanned pregnancy; Unwanted pregnancy; Preconception care; Prenatal care ID UNINTENDED PREGNANCY; INFANT-MORTALITY; UNITED-STATES; FOLIC-ACID; OUTCOMES; SMOKING; WOMEN; RISK; DISPARITIES; CAFFEINE AB Objectives Given that approximately half of all pregnancies in the United States are unplanned, the authors sought to understand the relation between pregnancy intention and health behaviors. Methods Mothers of live-born infants without major birth defects were interviewed as part of the National Birth Defects Prevention Study. The interview assessed pregnancy intention as well as exposures to vitamins, alcohol, tobacco, illicit drugs, occupational hazards, exogenous heat (e.g., hot tubs and saunas) and caffeine. Crude odds ratios and 95% confidence intervals were calculated and stratified analyses were performed to assess interaction. Multiple logistic regression was used to calculate adjusted odds ratios. Results Both before and after the diagnosis of pregnancy, women with unintended pregnancies were more likely to use illicit drugs, smoke, be exposed to environmental smoke, and not take folic acid or multivitamins. The degree to which women altered behaviors after they realized they were pregnant was also associated with their pregnancy intention status. For certain behaviors, maternal age or parity altered the association between pregnancy intention and changing behaviors after awareness of pregnancy. Conclusion Pregnancy intention status is a key determinant of pregnancy-related behavior. To improve reproductive outcomes, preconceptional and prenatal programs should consider a woman's desire for pregnancy. C1 [Dott, Mary] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Rasmussen, Sonja A.; Reefhuis, Jennita] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Hogue, Carol J.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Dott, M (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd NE,MS E-92, Atlanta, GA 30333 USA. EM mdott@cdc.gov RI Hogue, Carol/H-5442-2012; Reefhuis, Jennita/E-1793-2011; Publications, NBDPS/B-7692-2013 OI Reefhuis, Jennita/0000-0002-4747-4831; NR 35 TC 56 Z9 58 U1 1 U2 19 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAY PY 2010 VL 14 IS 3 BP 373 EP 381 DI 10.1007/s10995-009-0458-1 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 590RD UT WOS:000277244000008 PM 19252975 ER PT J AU Livingood, WC Brady, C Pierce, K Atrash, H Hou, T Bryant, T AF Livingood, William C. Brady, Carol Pierce, Kimberly Atrash, Hani Hou, Tao Bryant, Thomas, III TI Impact of Pre-Conception Health Care: Evaluation of a Social Determinants Focused Intervention SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Multiple determinants; Inter-conception care; Social status; Stress ID LOW-BIRTH-WEIGHT; ADVERSE PREGNANCY OUTCOMES; UNITED-STATES; PRECONCEPTIONAL HEALTH; AFRICAN-AMERICAN; INFANT-MORTALITY; BLOOD-PRESSURE; RISK-FACTORS; BLACK-WOMEN; MULTILEVEL ANALYSIS AB The purpose of this study was to evaluate the outcomes of the social determinants component of a multiple determinants model of pre- and inter-conception care. Health department vital statistics and infectious disease data on birth and factors influencing birth outcomes were analyzed for participants in a program designed to mitigate the effects of social class and stress in contrast to a matched comparison group and other relevant populations. The program showed promising results related to reducing infant mortality and reducing other high-risk factors for poor birth outcomes, including low birth weight and sexually transmitted disease. Social determinant interventions, designed to mitigate the impact of social class and stress, should be considered with efforts to reduce infant mortality, particularly the disparities associated with infant mortality. Additional research should be conducted to refine replicable social determinant focused interventions and confirm and generalize these results. C1 [Livingood, William C.; Pierce, Kimberly; Hou, Tao; Bryant, Thomas, III] Duval Cty Hlth Dept, Inst Hlth Policy & Evaluat Res, Jacksonville, FL 32211 USA. [Livingood, William C.] Univ Florida, Gainesville, FL 32611 USA. [Brady, Carol] NE Florida Healthy Start Coalit Inc, Jacksonville, FL 32211 USA. [Atrash, Hani] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Bryant, T (reprint author), Duval Cty Hlth Dept, Inst Hlth Policy & Evaluat Res, 900 Univ Blvd N,Suite 604, Jacksonville, FL 32211 USA. EM Thomas_Bryant@doh.state.fl.us NR 74 TC 19 Z9 19 U1 3 U2 13 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAY PY 2010 VL 14 IS 3 BP 382 EP 391 DI 10.1007/s10995-009-0471-4 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 590RD UT WOS:000277244000009 PM 19662521 ER PT J AU Conti, R Veenstra, DL Armstrong, K Lesko, LJ Grosse, SD AF Conti, Rena Veenstra, David L. Armstrong, Katrina Lesko, Lawrence J. Grosse, Scott D. TI Personalized Medicine and Genomics: Challenges and Opportunities in Assessing Effectiveness, Cost-Effectiveness, and Future Research Priorities SO MEDICAL DECISION MAKING LA English DT Article DE cost-effectiveness analysis; pharmacoeconomics; resource allocation ID EGAPP-WORKING-GROUP; POLICY IMPLICATIONS; DRUG DEVELOPMENT; GENETIC TESTS; WARFARIN; HEALTH; CANCER; INFORMATION; PHARMACOGENETICS; RECOMMENDATIONS AB Personalized medicine is health care that tailors interventions to individual variation in risk and treatment response. Although medicine has long strived to achieve this goal, advances in genomics promise to facilitate this process. Relevant to present-day practice is the use of genomic information to classify individuals according to disease susceptibility or expected responsiveness to a pharmacologic treatment and to provide targeted interventions. A symposium at the annual meeting of the Society for Medical Decision Making on 23 October 2007 highlighted the challenges and opportunities posed in translating advances in molecular medicine into clinical practice. A panel of US experts in medical practice, regulatory policy, technology assessment, and the financing and organization of medical innovation was asked to discuss the current state of practice and research on personalized medicine as it relates to their own field. This article reports on the issues raised, discusses potential approaches to meet these challenges, and proposes directions for future work. The case of genetic testing to inform dosing with warfarin, an anticoagulant, is used to illustrate differing perspectives on evidence and decision making for personalized medicine. C1 [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Conti, Rena] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA. [Conti, Rena] Univ Chicago, Ctr Hlth & Social Sci, Chicago, IL 60637 USA. [Veenstra, David L.] Univ Washington, Dept Pharm, Seattle, WA 98195 USA. [Armstrong, Katrina] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA. [Lesko, Lawrence J.] US FDA, Off Clin Pharmacol, Ctr Drug Evaluat & Res, Silver Spring, MD USA. RP Grosse, SD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,Mail Stop E-64, Atlanta, GA 30333 USA. EM SGrosse@cdc.gov FU Agency for Healthcare Research and Quality [R13 HS017305] FX Received 15 November 2008 from the Department of Pediatrics and Center for Health and the Social Sciences, University of Chicago, Chicago, Illinois (RC); Department of Pharmacy, University of Washington, Seattle (DLV); Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia (KA); Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (LJL); and National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia (SDG). Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the Food and Drug Administration. This material was presented in a symposium at the annual meeting of the Society for Medical Decision Making in Pittsburgh, Pennsylvania, on 12 October 2007. The symposium was supported by conference grant R13 HS017305 from the Agency for Healthcare Research and Quality. We acknowledge helpful comments on this manuscript from Cindy Bryce, William D. Dotson, and 4 anonymous reviewers. Revision accepted for publication 12 June 2009. NR 66 TC 45 Z9 46 U1 7 U2 31 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0272-989X J9 MED DECIS MAKING JI Med. Decis. Mak. PD MAY-JUN PY 2010 VL 30 IS 3 BP 328 EP 340 DI 10.1177/0272989X09347014 PG 13 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA 599EH UT WOS:000277892800008 PM 20086232 ER PT J AU Norris, J Pratt, M Duperly, J Lobelo, F AF Norris, Jeffrey Pratt, Michael Duperly, John Lobelo, Felipe TI Association between Physical Activity and Health Behaviors in Colombian Medical Students SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Norris, Jeffrey; Pratt, Michael; Lobelo, Felipe] Ctr Dis Control & Prevent, Atlanta, GA USA. [Duperly, John] Univ Los Andes, Sch Med, Bogota, Colombia. EM jnorris1@cdc.gov RI lobelo, felipe/B-9148-2013 NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1409 BP 263 EP 263 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301065 ER PT J AU Donado, C Collazos, V Mendoza, L Duperly, J Sarmiento, OL Lobelo, F AF Donado, Carolina Collazos, Vanessa Mendoza, Luisa Duperly, John Sarmiento, Olga L. Lobelo, Felipe TI Association between Physical Activity Levels, Perceived Barriers and Environmental Factors in Colombian Medical Students SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Duperly, John] Univ Los Andes, Fdn Santa Fe Bogota, Bogota, Colombia. [Lobelo, Felipe] Ctr Dis Control & Prevent, Atlanta, GA USA. EM g-donado@uniandes.edu.co RI lobelo, felipe/B-9148-2013 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1662 BP 355 EP 355 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301317 ER PT J AU Kelley, GA Kelley, KS Hootman, JM Jones, DL AF Kelley, George A. Kelley, Kristi S. Hootman, Jennifer M. Jones, Dina L. TI Effects Of Exercise On Pain And Physical Function In Adults With Arthritis: A Meta-Analysis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Kelley, George A.; Kelley, Kristi S.; Jones, Dina L.] W Virginia Univ, Morgantown, WV 26506 USA. [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM gkelley@hsc.wvu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1967 BP 461 EP 461 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301621 ER PT J AU Densmore, D Fulton, JE Carlson, SA AF Densmore, Dianna Fulton, Janet E. Carlson, Susan A. TI Walking: The MVP Of Aerobic Activities Among US Adults, Findings From Nhanes 1999-2006 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Densmore, Dianna; Fulton, Janet E.; Carlson, Susan A.] CDC, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA. EM ddensmore@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2383 BP 607 EP 607 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302185 ER PT J AU Hootman, JM Carlson, S AF Hootman, Jennifer M. Carlson, Susan TI Prevalence of Meeting the Physical Activity Guidelines for Americans among Adults With and Without Arthritis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Hootman, Jennifer M.; Carlson, Susan] Ctr Dis Control & Prevent, Atlanta, GA USA. EM jhootman@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2382 BP 607 EP 607 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302184 ER PT J AU Churilla, JR Magyari, PM Ford, ES Fitzhugh, EC AF Churilla, James R. Magyari, Peter M. Ford, Earl S. Fitzhugh, Eugene C. TI Muscular Strengthening Activity Patterns and Metabolic Health Risk Among US Adults:1999-2004 NHANES SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Churilla, James R.; Magyari, Peter M.] Univ N Florida, Jacksonville, FL USA. [Ford, Earl S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Fitzhugh, Eugene C.] Univ Tennessee, Knoxville, TN USA. EM j.churilla@unf.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2385 BP 608 EP 608 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302187 ER PT J AU Callaghan, WM Chu, SY Jamieson, DJ AF Callaghan, William M. Chu, Susan Y. Jamieson, Denise J. TI Deaths From Seasonal Influenza Among Pregnant Women in the United States, 1998-2005 SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID PANDEMIC INFLUENZA; ASIAN INFLUENZA; MORTALITY; EPIDEMIC; A(H1N1) AB OBJECTIVE: To estimate pregnancy-related mortality caused by seasonal influenza in the United States for comparison with the current 2009 influenza A H1N1 pandemic. METHODS: Pregnancy-related deaths were identified in the U.S. Centers for Disease Control and Prevention's (CDC) Pregnancy Mortality Surveillance System (PMSS) database for the years 1998-2005. PMSS collects de-identified copies of vital records supplied by all 50 states, the District of Columbia, and New York City for women who died during or within 1 year after pregnancy. Records in the database broadly classified under deaths due to respiratory infections were identified, and the corresponding archived death certificates were individually reviewed to classify the cause of death as pneumonia or influenza. RESULTS: Between 1998 and 2005, 4,693 pregnancy-related deaths were reported to CDC. Of these, 78 women died from influenza or pneumonia; 40 of these deaths occurred during an influenza season. Nearly 75% of deaths occurred during or within 2 weeks of the end of the pregnancy. CONCLUSION: On average, five possible influenza-related deaths among pregnant women were reported per year before the emergence of pregnancy-related deaths due to the current H1N1 pandemic compared with the 28 laboratory-confirmed, pregnancy-related deaths reported for the first 4 months of the 2009 pandemic. This highlights the excess mortality among pregnant women resulting from this pandemic influenza virus. (Obstet Gynecol 2010;115:919-23) C1 [Callaghan, William M.; Chu, Susan Y.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS K-23, Atlanta, GA 30341 USA. EM wgc0@cdc.gov NR 15 TC 34 Z9 37 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2010 VL 115 IS 5 BP 919 EP 923 DI 10.1097/AOG.0b013e3181d99d85 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 589WV UT WOS:000277185800006 PM 20410763 ER PT J AU Carreon, T Hein, MJ Viet, SM Hanley, KW Ruder, AM Ward, EM AF Carreon, Tania Hein, Misty J. Viet, Susan M. Hanley, Kevin W. Ruder, Avima M. Ward, Elizabeth M. TI Increased bladder cancer risk among workers exposed to o-toluidine and aniline: a reanalysis SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID EXPOSURES; EXCESS AB Introduction In 1991, the US National Institute for Occupational Safety and Health (NIOSH) reported an increased bladder cancer risk in a cohort of 1749 workers potentially exposed to o-toluidine and aniline at a chemical manufacturing plant. As additional information showed that workers in certain departments had been misclassified regarding o-toluidine exposure, we therefore conducted a reanalysis of the data using updated exposure categories. Methods We updated exposure categories based on information ascertained during a plant walkthrough, documents on file at the plant, interviews with current and former employees, and answers provided by company and union officials to specific questions. Bladder cancer incidence was determined through 31 December 1988 and mortality through 31 December 1994. Results Thirteen cases of bladder cancer were observed versus 3.57 expected (New York State rates excluding New York City) (standardised incidence ratio (SIR) 3.64, 95% CI 1.94 to 6.23). Among workers classified as definitely exposed, increasing risks were observed for longer duration of employment (for >= 10 years, standardised rate ratio (SRR) 6.07, 95% CI 0.77 to 48.17) and time since first employment in the exposed departments (for >= 20 years, SRR 3.39, 95% CI 0.40 to 29.03). One bladder cancer death was observed among those definitely exposed. Conclusions These findings are comparable to the results reported earlier by NIOSH, and confirm that workers in this plant have an increased risk of bladder cancer. C1 [Carreon, Tania; Hein, Misty J.; Hanley, Kevin W.; Ruder, Avima M.; Ward, Elizabeth M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Viet, Susan M.] Westat Corp, Rockville, MD USA. [Ward, Elizabeth M.] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. RP Carreon, T (reprint author), 4676 Columbia Pkwy,Mailstop R-15, Cincinnati, OH 45226 USA. EM TCarreonValencia@cdc.gov RI Ruder, Avima/I-4155-2012 OI Ruder, Avima/0000-0003-0419-6664 FU CDC/NIOSH FX This study was funded by CDC/NIOSH operating funds. NR 7 TC 12 Z9 12 U1 0 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD MAY PY 2010 VL 67 IS 5 BP 348 EP 350 DI 10.1136/oem.2009.051136 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 592MN UT WOS:000277383300013 PM 19884651 ER PT J AU Pan, IJ Daniels, JL Herring, AH Rogan, WJ Siega-Riz, AM Goldman, BD Sjodin, A AF Pan, I-Jen Daniels, Julie L. Herring, Amy H. Rogan, Walter J. Siega-Riz, Anna Maria Goldman, Barbara D. Sjodin, Andreas TI Lactational exposure to polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene and infant growth: an analysis of the Pregnancy, Infection, and Nutrition Babies Study SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE breast milk contaminants; PCBs; DDT; DDE; endocrine disruptors; infant growth ID POLYBROMINATED DIPHENYL ETHERS; ANDROGEN RECEPTOR; PRENATAL EXPOSURE; CHILDHOOD GROWTH; BREAST-MILK; IN-UTERO; CHILDREN; PCBS; LIFE; HEALTH AB Polychlorinated biphenyls (PCB), 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT) and 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), the most stable metabolite of p,p'-DDT, are persistent organic pollutants and environmental endocrine disruptors. Infant exposure to these chemicals through breast feeding may influence children's growth, but this potential adverse effect could be complicated by the coexisting benefits of breast feeding. This study examined the associations between lactational exposure to these chemicals and infant growth in the first 12 months by using data from the Pregnancy, Infection and Nutrition Babies Study in central North Carolina, United States, 2004-06. The study population was restricted to the infants who were breast fed for 6 months or longer. PCBs, p,p'-DDT and p,p'-DDE were measured in breast milk at 3 months postpartum. Lactational exposure up to 12 months of age was estimated as the product of chemical concentrations and the duration of breast feeding. The infant's weight and length were recorded from the medical record for each routine paediatric well-child visit in the first 12 months. Women - child pairs who breast fed for 6 months or longer and returned the growth card (n = 210) were included in the study. Linear mixed effects models were used to assess the associations between chemical concentrations in breast milk and longitudinal infant weight and length measurements in the first 6 months. Multivariable linear regression models were used to assess the relationships between lactational exposure to chemicals until 12 months of age and the z-scores of infant weight, length and weight-for-length at 12 months. Overall, no association was observed. Breast feeding for 6 months or longer, with lactational exposure to PCBs, p,p'-DDT and p,p'-DDE at the low background level concentrations studied here, resulted in no measurable influence on infant growth in the first 12 months. C1 [Pan, I-Jen; Daniels, Julie L.; Siega-Riz, Anna Maria] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Daniels, Julie L.] Univ N Carolina, Dept Maternal & Child Hlth, Chapel Hill, NC 27599 USA. [Herring, Amy H.] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. [Herring, Amy H.; Siega-Riz, Anna Maria] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27599 USA. [Siega-Riz, Anna Maria] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA. [Goldman, Barbara D.] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27599 USA. [Rogan, Walter J.] NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA. [Sjodin, Andreas] Ctr Dis Control & Prevent, Organ Analyt Toxicol Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Daniels, JL (reprint author), Univ N Carolina, Dept Epidemiol, CB 7435, Chapel Hill, NC 27599 USA. EM julie_daniels@unc.edu RI Sjodin, Andreas/F-2464-2010; Rogan, Walter/I-6034-2012 OI Rogan, Walter/0000-0002-9302-0160 FU National Institute of Environmental Health Sciences [P30ES10126]; U.S. Environmental Protection Agency [RD832736]; Intramural Research Program; National Institute of Environmental Health Sciences; National Institutes of Health FX This work was supported by the National Institute of Environmental Health Sciences [grant number P30ES10126]; and the U.S. Environmental Protection Agency [grant number RD832736]. Dr Rogan's work on this project was supported by the Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health. NR 43 TC 23 Z9 25 U1 2 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-5022 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD MAY PY 2010 VL 24 IS 3 BP 262 EP 271 DI 10.1111/j.1365-3016.2010.01114.x PG 10 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 581DO UT WOS:000276501800008 PM 20415756 ER PT J AU Fagan, RP Kim, HJ AF Fagan, Ryan P. Kim, Hye-Joo TI SOURCE OF BOTULINUM ANTITOXIN PRODUCTS NEEDS CLARIFYING SO PEDIATRIC ANNALS LA English DT Letter C1 [Fagan, Ryan P.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Atlanta, GA USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 J9 PEDIATR ANN JI Pediatr. Annu. PD MAY PY 2010 VL 39 IS 5 BP 261 EP 262 DI 10.3928/00904481-20100422-02 PG 2 WC Pediatrics SC Pediatrics GA 595GT UT WOS:000277599400002 PM 20521425 ER PT J AU Connolly, GN Richter, P Aleguas, A Pechacek, TF Stanfill, SB Alpert, HR AF Connolly, Gregory N. Richter, Patricia Aleguas, Alfred, Jr. Pechacek, Terry F. Stanfill, Stephen B. Alpert, Hillel R. TI Unintentional Child Poisonings Through Ingestion of Conventional and Novel Tobacco Products SO PEDIATRICS LA English DT Article DE tobacco control policy; poisoning exposures; toxicity ID SMOKELESS TOBACCO; UNITED-STATES; NICOTINE AB OBJECTIVE: This study examines child poisonings resulting from ingestion of tobacco products throughout the nation and assesses the potential toxicity of novel smokeless tobacco products, which are of concern with their discreet form, candy-like appearance, and added flavorings that may be attractive to young children. METHODS: Data representing all single-substance, accidental poisonings resulting from ingestion of tobacco products by children < 6 years of age, reported to poison control centers, were examined. Age association with ingestion of smokeless tobacco versus other tobacco products was tested through logistic regression. Total nicotine content, pH, and un-ionized nicotine level were determined, and the latter was compared with values for moist snuff and cigarettes. RESULTS: A total of 13 705 tobacco product ingestion cases were reported, > 70% of which involved infants < 1 year of age. Smokeless tobacco products were the second most common tobacco products ingested by children, after cigarettes, and represented an increasing proportion of tobacco ingestions with each year of age from 0 to 5 years (odds ratio: 1.94 [95% confidence interval: 1.86-2.03]). A novel, dissolvable, smokeless tobacco product with discreet form, candy-like appearance, and added flavorings was found to contain an average of 0.83 mg of nicotine per pellet, with an average pH of 7.9, which resulted in an average of 42% of the nicotine in the un-ionized form. CONCLUSION: In light of the novelty and potential harm of dissolvable nicotine products, public health authorities are advised to study these products to determine the appropriate regulatory approach. Pediatrics 2010; 125:896-899 C1 [Connolly, Gregory N.; Alpert, Hillel R.] Harvard Univ, Sch Publ Hlth, Div Publ Hlth Practice, Boston, MA 02215 USA. [Richter, Patricia; Pechacek, Terry F.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA. [Stanfill, Stephen B.] Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Atlanta, GA USA. [Aleguas, Alfred, Jr.] No Ohio Poison Control Ctr, Cleveland, OH USA. RP Alpert, HR (reprint author), Harvard Univ, Sch Publ Hlth, Div Publ Hlth Practice, Landmark Bldg,Floor 3E,401 Pk Dr, Boston, MA 02215 USA. EM halpert@hsph.harvard.edu NR 13 TC 29 Z9 29 U1 0 U2 10 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 IS 5 BP 896 EP 899 DI 10.1542/peds.2009-2835 PG 4 WC Pediatrics SC Pediatrics GA 590NI UT WOS:000277232800005 PM 20403932 ER PT J AU Broyles, S Katzmarzyk, PT Srinivasan, SR Chen, W Bouchard, C Freedman, DS Berenson, GS AF Broyles, Stephanie Katzmarzyk, Peter T. Srinivasan, Sathanur R. Chen, Wei Bouchard, Claude Freedman, David S. Berenson, Gerald S. TI The Pediatric Obesity Epidemic Continues Unabated in Bogalusa, Louisiana SO PEDIATRICS LA English DT Article DE overweight; obesity; trends; rural ID UNITED-STATES; US CHILDREN; PHYSICAL-ACTIVITY; RISK-FACTORS; ADOLESCENTS; OVERWEIGHT; PREVALENCE; REGRESSION; CHILDHOOD; ADULTS AB OBJECTIVES: To examine 35-year trends in the prevalence of overweight and obesity among children and adolescents from Bogalusa, Louisiana. PATIENTS AND METHODS: Height and weight were measured for 11 653 children and adolescents between 5 and 17 years of age in 8 cross-sectional surveys. The Bogalusa Heart Study contributed data from 1973-1994, and routine school screening provided 2008-2009 data. Trends in mean BMI, mean gender-specific BMI-for-age z scores, prevalence of overweight/obesity (BMI >= 85th percentile), and prevalence of obesity (BMI >= 95th percentile) according to age, race, and gender were examined. RESULTS: Since 1973-1974, the proportion of children and adolescents aged 5 to 17 years who are overweight (overweight plus obese) has more than tripled, from 14.2% to 48.4% in 2008-2009. Similarly, the proportion of obese children and adolescents has increased more than fivefold from 5.6% in 1973-1974 to 30.8% in 2008-2009. The prevalence of overweight or obesity, and secular changes, were similar among black and white boys and girls. CONCLUSIONS: In semirural Bogalusa, the childhood obesity epidemic has not plateaued, and nearly half of the children are now overweight or obese. Pediatrics 2010; 125:900-905 C1 [Broyles, Stephanie; Katzmarzyk, Peter T.; Bouchard, Claude] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Srinivasan, Sathanur R.; Chen, Wei; Berenson, Gerald S.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Tulane Ctr Cardiovasc Hlth, New Orleans, LA USA. [Freedman, David S.] Ctr Dis Control & Prevent, Div Nutr Phys Activ & Obes, Atlanta, GA USA. RP Katzmarzyk, PT (reprint author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. EM peter.katzmarzyk@pbrc.edu RI Bouchard, Claude/A-7637-2009; Broyles, Stephanie/C-8647-2011; Fruyt, Sofie/F-6843-2011; OI Katzmarzyk, Peter/0000-0002-9280-6022 FU National Institutes of Health,National Heart, Lung, and Blood Institute [HL-38844]; National Institutes of Health, National Institute on Aging [AG-16592]; National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development [HD-043820] FX This work was supported by National Institutes of Health grants HL-38844 (National Heart, Lung, and Blood Institute), AG-16592 (National Institute on Aging), and HD-043820 (Eunice Kennedy Shriver National Institute of Child Health and Human Development). Dr Katzmar-zyk is supported, in part, by the Louisiana Public Facilities Authority Endowed Chair in Nutrition. Dr Bouchard is supported, in part, by the George A. Bray Chair in Nutrition. NR 22 TC 52 Z9 53 U1 0 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 IS 5 BP 900 EP 905 DI 10.1542/peds.2009-2748 PG 6 WC Pediatrics SC Pediatrics GA 590NI UT WOS:000277232800006 PM 20368311 ER PT J AU Kempe, A Babbel, C Wallace, GS Stokley, S Daley, MF Crane, LA Beaty, B Black, SR Barrow, J Dickinson, LM AF Kempe, Allison Babbel, Christine Wallace, Gregory S. Stokley, Shannon Daley, Matthew F. Crane, Lori A. Beaty, Brenda Black, Sandra R. Barrow, Jennifer Dickinson, L. Miriam TI Knowledge of Interim Recommendations and Use of Hib Vaccine During Vaccine Shortages SO PEDIATRICS LA English DT Article DE child immunization; Haemophilus influenzae type b recall; Haemophilus influenzae type b shortage; physician practices; survey AB OBJECTIVES: The goals were to determine among pediatricians and family physicians (1) knowledge of interim recommendations regarding Haemophilus influenzae type b (Hib) vaccine administration, (2) current practices, and (3) factors associated with nonadherence. METHODS: An Internet-based survey was conducted in April 2008 among national samples. RESULTS: Response rates were 68% (220 of 325 physicians) among pediatricians and 51% (153 of 302 physicians) among family physicians. Seventy-three percent of pediatricians and 45% of family medicine physicians reported insufficient Hib vaccine supplies, and 22% to 24% reported having to defer doses for infants 2 to 6 months of age >= 10% of the time. Ninety-eight percent of pediatricians and 81% of family physicians were aware of the interim recommendations (P <= 0001), and virtually all knew that the booster dose should be deferred; however, 22% of pediatricians and 33% of family medicine physicians reported not deferring this dose. Physicians in both specialties were less likely to adhere to recommendations to defer in this age group if they thought that their practice had sufficient vaccine supplies (pediatricians, odds ratio: 0.01 [95% confidence interval: 0.003-0.03]; family medicine physicians, odds ratio: 0.10 [95% confidence interval: 0.030.33]). Family medicine physicians were less likely to adhere to recommendations if they had not heard about the interim recommendations (odds ratio: 0.04 [95% confidence interval: 0.01-0.21]). CONCLUSIONS: Most primary care physicians experienced Hib vaccine shortages, and many have had to defer doses for 2- to 6-month-old children. Most are knowledgeable regarding interim recommendations, but one-fifth to one-third reported nonadherence. Pediatrics 2010;125:914-920 C1 [Kempe, Allison; Daley, Matthew F.] Univ Colorado, Dept Pediat, Aurora, CO 80045 USA. [Dickinson, L. Miriam] Univ Colorado, Dept Family Med, Aurora, CO 80045 USA. [Kempe, Allison; Babbel, Christine; Daley, Matthew F.; Beaty, Brenda; Black, Sandra R.; Barrow, Jennifer] Univ Colorado, Colorado Hlth Outcomes Program, Aurora, CO 80045 USA. [Kempe, Allison; Babbel, Christine; Daley, Matthew F.; Crane, Lori A.; Beaty, Brenda; Black, Sandra R.; Barrow, Jennifer] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO USA. [Wallace, Gregory S.; Stokley, Shannon] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Crane, Lori A.] Colorado Sch Publ Hlth, Dept Prevent Med & Biometr, Aurora, CO USA. RP Kempe, A (reprint author), Univ Colorado, Dept Pediat, 12477 E 19th Ave,Mailstop F443, Aurora, CO 80045 USA. EM kempe.allison@tchden.org FU CDC [SIP 5 U48 DP000054-03] FX This investigation was funded by a grant from the CDC (grant SIP 5 U48 DP000054-03) to the Rocky Mountain Prevention Research Center, University of Colorado (Denver, CO). NR 12 TC 7 Z9 7 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 IS 5 BP 914 EP 920 DI 10.1542/peds.2009-1710 PG 7 WC Pediatrics SC Pediatrics GA 590NI UT WOS:000277232800008 PM 20403935 ER PT J AU Hertzberg, V Mei, J Therrell, BL AF Hertzberg, Vicki Mei, Joanne Therrell, Bradford L. TI Effect of Laboratory Practices on the Incidence Rate of Congenital Hypothyroidism SO PEDIATRICS LA English DT Article DE hypothyroidism; incidence rate; newborn screening; diagnosis; laboratory methodology ID LONGITUDINAL DATA-ANALYSIS; SCREENING-PROGRAM; NEONATAL HYPOTHYROIDISM; THYROXINE AB OBJECTIVE: Newborn screening (NBS) laboratories in the United States expanded their programs to include primary congenital hypothyroidism (CH) in the 1970s. An increase in the national CH-incidence rate since 1987 has been reported. Our goal was to analyze national data reported by state NBS programs and laboratories from 1991 to 2000 to determine the extent to which changing laboratory methods might have contributed to the reported rise in CH-incidence rate. METHODS: We used generalized estimating equations to analyze the association between the rate of confirmed cases of CH per 100 000 live births and the initial screening method (thyroxine [T4] or thyrotropin [TSH] assay), the T4- and TSH-assay methods, the screening-test cutoff value used to report abnormal T4- or thyrotropin-assay results, and the performance of a second screen on >= 80% of newborns in the state. We then evaluated the association of CH rate with year after adjusting for any screening methodology or parameter that was significant in the univariate analysis. RESULTS: During 1991-2000, laboratories that used a TSH assay for initial screening reported a 24% higher incidence rate of CH than those that used a T4 assay. The assay type also affected the incidence rate. Screening for T4 by enzyme immunometric assay (EIA) or fluoroimmunoassay (FIA) methods resulted in 38% and 24% higher incidence rates of CH, respectively, compared with the radioimmunoassay (RIA) method, whereas screening for TSH by the FIA method resulted in a 20% higher incidence rate of CH than did screening with radiochemical methods. During the decade studied, many laboratories changed their T4-assay method from RIA to either FIA or EIA; this particular change seemed to have the greatest impact on the CH-incidence rate. CONCLUSIONS: Although the use of different laboratory methods and screening practices by NBS laboratories affected the incidence rate of CH, after adjusting for screening methodologies and parameters, an increasing incidence rate still persisted during the decade studied. Thus, there seem to be additional unknown factors that contributed to the reported increase in incidence rate. Pediatrics 2010; 125: S48-S53 C1 [Hertzberg, Vicki] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA 30322 USA. [Mei, Joanne] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Natl Ctr Environm Hlth, Atlanta, GA USA. [Therrell, Bradford L.] Univ Texas Hlth Sci Ctr San Antonio, Natl Newborn Screening & Genet Resource Ctr, Austin, TX USA. RP Hertzberg, V (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM vhertzb@sph.emory.edu NR 18 TC 13 Z9 13 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 SU S BP S48 EP S53 DI 10.1542/peds.2009-1975E PG 6 WC Pediatrics SC Pediatrics GA 597MU UT WOS:000277762800003 PM 20435717 ER PT J AU Hinton, CF Harris, KB Borgfeld, L Drummond-Borg, M Eaton, R Lorey, F Therrell, BL Wallace, J Pass, KA AF Hinton, Cynthia F. Harris, Katharine B. Borgfeld, Lynette Drummond-Borg, Margaret Eaton, Roger Lorey, Fred Therrell, Bradford L. Wallace, Jill Pass, Kenneth A. TI Trends in Incidence Rates of Congenital Hypothyroidism Related to Select Demographic Factors: Data From the United States, California, Massachusetts, New York, and Texas SO PEDIATRICS LA English DT Article DE congenital hypothyroidism; race; ethnicity; sex; preterm birth; low birth weight ID LOW-BIRTH-WEIGHT; THYROID-FUNCTION; RISK-FACTORS; INFANTS; HYPOTHYROXINEMIA; NEWBORN; PREMATURITY; PREGNANCY; ETHNICITY; MORTALITY AB Primary congenital hypothyroidism (CH) is a common and preventable cause of intellectual disability. The incidence rate of CH has been reported to be increasing in the United States, but the factors behind the observed rate increase are not known. We summarize here the data presented at a workshop on CH, at which factors potentially related to the CH-incidence-rate increase (namely, race, ethnicity, sex, and birth outcomes) were evaluated. Data sources for the analyses included a national data set of newborn-screening results and state-specific data from newborn-screening programs in California, Massachusetts, New York, and Texas. The incidence rate of CH increased in the United States by 3% per year; however, an increase did not occur in all states, at a constant rate, or even at the same rate. Analysis of US data (19912000) showed a CH-incidence-rate increase only among white new-borns. More recently, in California (2000-2007), the rate was constant in non-Hispanic newborns, but it increased among Hispanic newborns. In the national data, the CH-incidence rate increased similarly among boys and girls, whereas in Texas (1992-2006), the rate among boys increased significantly more than among girls and varied according to race and ethnicity. In Massachusetts (1995-2007), low birth weight newborns or newborns who had a delayed rise in thyrotropin concentration accounted for the majority of the recent rate increase. Race, ethnicity, sex, and pregnancy outcomes have affected the observed increasing incidence rate of CH, although there have been some inconsistencies and regional differences. The association with preterm birth or low birth weight could reflect the misclassification of some cases of transient hypothyroxinemia as true CH. Future studies of risk factors should focus on correct initial identification and reporting of demographic characteristics and pregnancy outcomes for cases of CH. In addition, long-term follow-up data of presumed cases of CH should be ascertained to differentiate true cases of CH from cases of transient hypothyroidism. Pediatrics 2010; 125: S37-S47 C1 [Hinton, Cynthia F.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Harris, Katharine B.; Pass, Kenneth A.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Borgfeld, Lynette; Drummond-Borg, Margaret] Dept State Hlth Serv, Austin, TX USA. [Drummond-Borg, Margaret] Cook Childrens Phys Network, Ft Worth, TX USA. [Eaton, Roger] Univ Massachusetts, Sch Med, New England Reg Newborn Screening Program, Jamaica Plain, MA USA. [Lorey, Fred] Calif Dept Publ Hlth, Genet Dis Screening Program, Richmond, CA USA. [Therrell, Bradford L.] Univ Texas Hlth Sci Ctr San Antonio, Natl Newborn Screening & Genet Resource Ctr, Austin, TX USA. RP Hinton, CF (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,Mailstop E-86, Atlanta, GA 30333 USA. EM chinton@cdc.gov NR 28 TC 53 Z9 54 U1 0 U2 9 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 SU S BP S37 EP S47 DI 10.1542/peds.2009-1975D PG 11 WC Pediatrics SC Pediatrics GA 597MU UT WOS:000277762800002 PM 20435716 ER PT J AU Olney, RS Grosse, SD Vogt, RF AF Olney, Richard S. Grosse, Scott D. Vogt, Robert F., Jr. TI Prevalence of Congenital Hypothyroidism-Current Trends and Future Directions: Workshop Summary SO PEDIATRICS LA English DT Article DE congenital hypothyroidism; neonatal screening; epidemiology; public health; conferences ID PERCHLORATE EXPOSURE; IODINE NUTRITION; UNITED-STATES; RISK-FACTORS; POPULATION; INCREASE AB In response to published newborn-screening data that have shown an increase in the incidence (birth prevalence) rate of primary congenital hypothyroidism (CH) in the United States, a workshop was held in Atlanta, Georgia, on February 27 and 28, 2008, to examine this issue. Topics of the meeting included pathophysiology, medical management, and follow-up of CH; transient hypothyroidism (etiology, clinical implications, management, and changes in prevalence); risk factors for CH; laboratory approaches to newborn screening for CH; state-specific evaluations of trends in incidence rates of CH; and concluding discussions on future directions to resolve outstanding issues. Through presentations and discussion, gaps in knowledge were identified, such as the lack of consistent definitions for CH and transient hypothyroidism and the effects of preventable risk factors on incidence rates of CH. One outcome of the meeting was a series of accompanying articles that examined (1) trends in the incidence rates of CH in individual states and nationally, (2) effects of newborn-screening practices on CH-incidence rates, (3) the contribution of transient hypothyroidism to CH-incidence rates, and (4) future research directions. In this summary, we briefly touch on the topics of these articles and examine highlights of other presentations from the workshop that illuminated the secular trends in reported CH-incidence rates in the United States. Pediatrics 2010; 125: S31-S36 C1 [Olney, Richard S.; Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. RP Olney, RS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,Mailstop E-86, Atlanta, GA 30333 USA. EM rolney@cdc.gov NR 26 TC 26 Z9 27 U1 1 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 SU S BP S31 EP S36 DI 10.1542/peds.2009-1975C PG 6 WC Pediatrics SC Pediatrics GA 597MU UT WOS:000277762800001 PM 20435715 ER PT J AU Parks, JS Lin, M Grosse, SD Hinton, CF Drummond-Borg, M Borgfeld, L Sullivan, KM AF Parks, John S. Lin, Michelle Grosse, Scott D. Hinton, Cynthia F. Drummond-Borg, Margaret Borgfeld, Lynette Sullivan, Kevin M. TI The Impact of Transient Hypothyroidism on the Increasing Rate of Congenital Hypothyroidism in the United States SO PEDIATRICS LA English DT Article DE transient hypothyroidism; hyperthyrotropinemia; thyrotropin receptor-blocking antibodies; antithyroid drugs; iodine; thyroid imaging ID IODINE-CONTAINING ANTISEPTICS; NATIONAL-HEALTH; SUBCLINICAL HYPOTHYROIDISM; NEONATAL-HYPOTHYROIDISM; NEW-YORK; DEFICIENCY; NUTRITION; DIAGNOSIS; POPULATION; CHILDREN AB The reported incidence rate of primary congenital hypothyroidism (CH) has been increasing in the United States over the past 2 decades. We have considered the possibility that the inclusion of cases of transient hypothyroidism has inflated the reported incidence rate of CH. Assessing the effects of cases of transient hypothyroidism on the incidence rate is problematic, because the definitions, diagnostic criteria, and differentiation from transient hyperthyrotropinemia vary widely among state newborn screening programs. Among the 4 etiologies for transient hypothyroidism (maternal thyrotropin receptor-blocking antibodies, exposure to maternal antithyroid medications, iodine deficiency, and iodine excess), there is little evidence of increases in the incidence rate from thyrotropin receptor-blocking antibodies. Exposure to antithyroid drugs could contribute significantly to the incidence rate of transient CH, given the high estimated incidence of active maternal hyperthyroidism. Iodine deficiency or excess in the United States seems unlikely to have contributed significantly to the incidence rate of CH, because the secular trend toward lower iodine intake among women of reproductive age in the 1980s and 1990s seems to have plateaued, and perinatal iodine exposure has presumably declined as a result of recommendations to discontinue using iodine-containing disinfectants. Although the female-to-male sex ratio among newborns with thyroid agenesis or dysgenesis (the most common causes of CH) is typically 2: 1, analysis of the sex ratio of newborns diagnosed with presumed CH in the United States suggests that a substantial proportion might have transient hypothyroidism or hyperthyrotropinemia, because the sex ratio has been well below the expected 2: 1 ratio. Combined ultrasonography and I-123 scintigraphy of the thyroid gland are effective tools for identifying cases of thyroid agenesis and dysgenesis and can help to differentiate cases of transient hypothyroidism from true CH. Imaging is also a vital component in evaluating children who, at 3 years of age, undergo a trial of discontinuation of levothyroxine treatment to test for persistence of hypothyroidism. Ultimately, thyroid gland imaging, in conjunction with long-term follow-up studies that appropriately assess and report whether there was permanence of hypothyroidism, will be necessary to address the true incidence rate of CH and any contribution to the observed rate by transient cases of hypothyroidism or hyperthyrotropinemia. Pediatrics 2010; 125: S54-S63 C1 [Parks, John S.] Emory Univ, Sch Med, Emory Childrens Ctr, Dept Pediat,Div Pediat Endocrinol, Atlanta, GA 30322 USA. [Grosse, Scott D.; Hinton, Cynthia F.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Drummond-Borg, Margaret; Borgfeld, Lynette] Dept State Hlth Serv, Austin, TX USA. [Drummond-Borg, Margaret] Cook Childrens Phys Network, Ft Worth, TX USA. [Sullivan, Kevin M.] Emory Univ, Rollins Sch Pubic Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. RP Parks, JS (reprint author), Emory Univ, Sch Med, Emory Childrens Ctr, Dept Pediat,Div Pediat Endocrinol, 2015 Upper Gate Dr, Atlanta, GA 30322 USA. EM jparks@emory.edu RI Parks, John/F-8570-2011 NR 47 TC 36 Z9 39 U1 0 U2 6 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 SU S BP S54 EP S63 DI 10.1542/peds.2009-1975F PG 10 WC Pediatrics SC Pediatrics GA 597MU UT WOS:000277762800004 PM 20435718 ER PT J AU Shapira, SK Lloyd-Puryear, MA Boyle, C AF Shapira, Stuart K. Lloyd-Puryear, Michele A. Boyle, Coleen TI Future Research Directions to Identify Causes of the Increasing Incidence Rate of Congenital Hypothyroidism in the United States SO PEDIATRICS LA English DT Article DE hypothyroidism; incidence; newborn screening; diagnosis; risk factor; public health ID THYROID DYSGENESIS; NATIONAL-HEALTH; RISK-FACTORS; POPULATION; AUSTRALIA AB A workshop to evaluate the reported increasing trend in the incidence rate of primary congenital hypothyroidism (CH) identified by newborn screening was held February 27 and 28, 2008, in Atlanta, Georgia, and was sponsored by the Centers for Disease Control and Prevention, the Health Resources and Services Administration, and the National Newborn Screening and Genetics Resource Center. Through a series of presentations and discussions, this group of experts considered a variety of factors that could be contributing to the perceived increasing trend of the CH-incidence rate, the gaps in knowledge that need to be overcome to identify the causes of the observed trend, and possible future research activities that might resolve the uncertainties surrounding the increasing incidence rate of CH in the United States. On the basis of these discussions, workshop participants concluded that the initial focus of future efforts should be to determine if the increasing CH-incidence rate persists once there is standardization of the diagnostic criteria for the classification of CH versus transient hypothyroidism. In discussions, workshop participants suggested that if the increasing incidence rate of CH could not be explained by definitional issues, then future research could focus on the identification and evaluation of risk factors for CH that might be changing among the US population and, thus, contributing to the observed increasing incidence rate of CH. Pediatrics 2010; 125: S64-S68 C1 [Shapira, Stuart K.; Boyle, Coleen] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, US Dept HHS, Atlanta, GA 30333 USA. [Lloyd-Puryear, Michele A.] US Hlth Resources & Serv Adm, Genet Serv Branch, Maternal & Child Hlth Bur, US Dept HHS, Rockville, MD 20857 USA. RP Shapira, SK (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, US Dept HHS, 1600 Clifton Rd,Mailstop E-86, Atlanta, GA 30333 USA. EM sshapira@cdc.gov NR 22 TC 6 Z9 7 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2010 VL 125 SU S BP S64 EP S68 DI 10.1542/peds.2009-1975G PG 5 WC Pediatrics SC Pediatrics GA 597MU UT WOS:000277762800005 PM 20435719 ER PT J AU Norman, SA Weber, AL Localio, AR Marchbanks, PA Ursin, G Strom, BL Weiss, LK Burkman, RT Bernstein, L Deapen, DM Folger, SG Simon, MS Nadel, MR AF Norman, Sandra A. Weber, Anita L. Localio, A. Russell Marchbanks, Polly A. Ursin, Giske Strom, Brian L. Weiss, Linda K. Burkman, Ronald T. Bernstein, Leslie Deapen, Dennis M. Folger, Suzanne G. Simon, Michael S. Nadel, Marion R. TI Hormone therapy and fatal breast cancer SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Article DE hormone replacement therapy; estrogen replacement therapy; estrogen progestin combination therapy; breast neoplasms; death; menopause; case-control ID ESTROGEN PLUS PROGESTIN; HEALTHY POSTMENOPAUSAL WOMEN; INITIATIVE RANDOMIZED-TRIAL; REPLACEMENT THERAPY; PROGNOSTIC-FACTORS; RISK; MAMMOGRAPHY; MORTALITY; REGIMENS; POPULATION AB Purpose Among unanswered questions is whether menopausal use of estrogen therapy (ET) or estrogen-plus-progestin therapy (CHT) increases risk of developing fatal breast cancer i.e., developing and dying of breast cancer. Using a population-based case-control design, we estimated incidence rate ratios of fatal breast cancer in postmenopausal hormone therapy (HT) users compared to non-users by type, duration, and recency of HT use. Methods HT use prior to breast cancer diagnosis in 278 women who died of breast cancer within 6 years of diagnosis (cases) was compared with use in 2224 controls never diagnosed with breast cancer using conditional logistic regression. Measures taken to address potential bias and confounding inherent in case-control studies included collecting and adjusting for detailed data on demographic and other factors potentially associated both with HT use and breast cancer. Results Fifty-six per cent of cases and 68% of controls reported HT use. Among current 3+ year HT users, odds ratios and 95% confidence intervals for death were 0.83 (0.50, 1.38) and 0.69 (0.44, 1.09), respectively, for exclusive use of CHT or of ET, and were 0.94 (0.59, 1.48) and 0.70 (0.45, 1.07) for any use of CHT or of ET regardless of other hormone use. Conclusion Point estimates suggest no increased risk of fatal breast cancer with HT use, although 50% increases in risk in longer-term current CHT users cannot be ruled out. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Norman, Sandra A.; Weber, Anita L.; Localio, A. Russell; Strom, Brian L.] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Norman, Sandra A.; Localio, A. Russell; Strom, Brian L.] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Marchbanks, Polly A.; Folger, Suzanne G.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Ursin, Giske; Bernstein, Leslie; Deapen, Dennis M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Ursin, Giske] Univ Oslo, Dept Nutr, N-0316 Oslo, Norway. [Weiss, Linda K.] NCI, Canc Ctr Branch, Bethesda, MD 20892 USA. [Burkman, Ronald T.] Baystate Med Ctr, Dept Obstet & Gynecol, Springfield, MA USA. [Bernstein, Leslie] City Hope Natl Med Ctr, Dept Canc Etiol, Duarte, CA 91010 USA. [Simon, Michael S.] Wayne State Univ, Dept Internal Med, Detroit, MI 48202 USA. [Simon, Michael S.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48202 USA. [Nadel, Marion R.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Norman, SA (reprint author), Univ Penn, Ctr Clin Epidemiol & Biostat, 8 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM snorman@mail.med.upenn.edu FU Centers for Disease Control and Prevention (CDC); Division of Cancer Prevention and Control [200-2002-00370]; National Institute of Child Health and Human Development (NICHD); NICHD; National Cancer Institute [N01-HD-3-3168]; Fred Hutchinson Cancer Research Center [N01-HD-2-3166]; Karmanos Cancer Institute at Wayne State University [N01-HD-3-3174]; University of Pennsylvania [N01-HD-3-3176]; University of Southern California [N01-HD-3-3175]; CDC [Y01-HD-7022]; Surveillance, Epidemiology and End Results Program [N01-PC-67006, N01-CN-65064, N01-PC-67010, N01-CN-0532] FX This study was funded by the Centers for Disease Control and Prevention (CDC), Division of Cancer Prevention and Control, through subcontracts to the Women's Contraceptive and Reproductive Experiences (CARE) Study through an interagency agreement with the National Institute of Child Health and Human Development (NICHD), and by CDC Division of Cancer Prevention and Control contract #200-2002-00370 with the University of Pennsylvania (Sandra A. Norman, P.I.). The Women's CARE Study was funded by the NICHD, with additional support from the National Cancer Institute, through contracts with Emory University (N01-HD-3-3168), Fred Hutchinson Cancer Research Center (N01-HD-2-3166), Karmanos Cancer Institute at Wayne State University (N01-HD-3-3174), the University of Pennsylvania (N01-HD-3-3176), and the University of Southern California (N01-HD-3-3175) and through an interagency agreement with CDC (Y01-HD-7022). CDC also contributed additional staff and computer support. General support was also provided through Surveillance, Epidemiology and End Results Program contracts N01-PC-67006 (Atlanta), N01-CN-65064 (Detroit), N01-PC-67010 (Los Angeles), and N01-CN-0532 (Seattle). The authors thank Noel S. Weiss, MD, DrPH for his many helpful suggestions on drafts of the paper. NR 43 TC 9 Z9 9 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD MAY PY 2010 VL 19 IS 5 BP 440 EP 447 DI 10.1002/pds.1941 PG 8 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 600LM UT WOS:000277987600003 PM 20336635 ER PT J AU Cruz, AR Pillay, A Zuluaga, AV Ramirez, LG Duque, JE Aristizabal, GE Fiel-Gan, MD Jaramillo, R Trujillo, R Valencia, C Jagodzinski, L Cox, DL Radolf, JD Salazar, JC AF Cruz, Adriana R. Pillay, Allan Zuluaga, Ana V. Ramirez, Lady G. Duque, Jorge E. Aristizabal, Gloria E. Fiel-Gan, Mary D. Jaramillo, Roberto Trujillo, Rodolfo Valencia, Carlos Jagodzinski, Linda Cox, David L. Radolf, Justin D. Salazar, Juan C. TI Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PALLIDUM SUBSP PALLIDUM; VIRULENT TREPONEMA-PALLIDUM; POLYMERASE-I GENE; OUTER-MEMBRANE; PREGNANT-WOMEN; UNITED-STATES; SOUTH-AFRICA; RISK-FACTORS; HEPATITIS-B; WHOLE-BLOOD AB Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia. To be eligible for participation, study subjects were required to have cutaneous lesions consistent with SS, a reactive Rapid Plasma Reagin test (RPR-titer >= 1:4), and a confirmatory treponemal test (Fluorescent Treponemal Antibody Absorption test-FTA-ABS). Most subjects enrolled were women (64.9%), predominantly Afro-Colombian (38.6%) or mestizo (56.1%), and all were of low socio-economic status. Three (5.3%) subjects were newly diagnosed with HIV infection at study entry. The duration of signs and symptoms in most patients (53.6%) was less than 30 days; however, some patients reported being symptomatic for several months (range 5-240 days). The typical palmar and plantar exanthem of SS was the most common dermal manifestation (63%), followed by diffuse hypo-or hyperpigmented macules and papules on the trunk, abdomen and extremities. Three patients had patchy alopecia. Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods. Twelve (46%) of the 26 WB samples studied had quantifiable Tp DNA (ranging between 194.9 and 1954.2 Tp polA copies/ml blood) and seven (64%) were positive when WB DNA was extracted within 24 hours of collection. Tp DNA was also present in 8/12 (66%) skin biopsies available for testing. Strain typing analysis was attempted in all skin and WB samples with detectable Tp DNA. Using arp repeat size analysis and tpr RFLP patterns four different strain types were identified (14d, 16d, 13d and 22a). None of the WB samples had sufficient DNA for typing. The clinical and microbiologic observations presented herein, together with recent Cali syphilis seroprevalence data, provide additional evidence that venereal syphilis is highly endemic in this region of Colombia, thus underscoring the need for health care providers in the region to be acutely aware of the clinical manifestations of SS. This study also provides, for the first time, quantitative evidence that a significant proportion of untreated SS patients have substantial numbers of circulating spirochetes. How Tp is able to persist in the blood and skin of SS patients, despite the known presence of circulating treponemal opsonizing antibodies and the robust pro-inflammatory cellular immune responses characteristic of this stage of the disease, is not fully understood and requires further study. C1 [Cruz, Adriana R.; Zuluaga, Ana V.; Ramirez, Lady G.; Duque, Jorge E.; Trujillo, Rodolfo; Valencia, Carlos] CIDEIM, Cali, Colombia. [Pillay, Allan; Cox, David L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Aristizabal, Gloria E.] Secretaria Salud Publ Municipal, Cali, Colombia. [Fiel-Gan, Mary D.] Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA. [Jaramillo, Roberto] Fdn Clin Valle del Lili, Cali, Colombia. [Jagodzinski, Linda] Walter Reed Army Inst Res, Rockville, MD USA. [Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT USA. [Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT USA. [Salazar, Juan C.] Univ Connecticut, Ctr Hlth, Dept Pediat, Farmington, CT USA. [Salazar, Juan C.] Connecticut Childrens Med Ctr, Div Infect Dis, Hartford, CT USA. RP Cruz, AR (reprint author), CIDEIM, Cali, Colombia. EM jsalaza@ccmckids.org FU Public Health Service [K23 AI62439, 5R03TW008023, AI-26756, AI-38894]; Connecticut Children's Medical Center (CCMC); COLCIENCIAS [222940820554] FX This work was supported in part by Public Health Service grants K23 AI62439 (JCS), 5R03TW008023 (JCS and AC), AI-26756 (JR), AI-38894 (JR), Connecticut Children's Medical Center's (CCMC) Arrison and Burr Curtis Research Funds (JCS) and COLCIENCIAS grant # 222940820554 (AC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 78 TC 22 Z9 24 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2010 VL 4 IS 5 AR e690 DI 10.1371/journal.pntd.0000690 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 608QO UT WOS:000278601000020 PM 20502522 ER PT J AU Hidron, AI Gilman, RH Justiniano, J Blackstock, AJ LaFuente, C Selum, W Calderon, M Verastegui, M Ferrufino, L Valencia, E Tornheim, JA O'Neal, S Comer, R Galdos-Cardenas, G Bern, C AF Hidron, Alicia I. Gilman, Robert H. Justiniano, Juan Blackstock, Anna J. LaFuente, Carlos Selum, Walter Calderon, Martiza Verastegui, Manuela Ferrufino, Lisbeth Valencia, Eduardo Tornheim, Jeffrey A. O'Neal, Seth Comer, Robert Galdos-Cardenas, Gerson Bern, Caryn CA Chagas Dis Working Grp Peru Bolivi TI Chagas Cardiomyopathy in the Context of the Chronic Disease Transition SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID POLYMERASE-CHAIN-REACTION; TRYPANOSOMA-CRUZI INFECTION; KINETOPLAST MINICIRCLE DNA; HEART-DISEASE; NUTRITION TRANSITION; PARASITE PERSISTENCE; GONADAL-HORMONES; BLOOD SPECIMENS; LATIN-AMERICA; ENDEMIC AREA AB Background: Patients with Chagas disease have migrated to cities, where obesity, hypertension and other cardiac risk factors are common. Methodology/Principal Findings: The study included adult patients evaluated by the cardiology service in a public hospital in Santa Cruz, Bolivia. Data included risk factors for T. cruzi infection, medical history, physical examination, electrocardiogram, echocardiogram, and contact 9 months after initial data collection to ascertain mortality. Serology and PCR for Trypanosoma cruzi were performed. Of 394 participants, 251 (64%) had confirmed T. cruzi infection by serology. Among seropositive participants, 109 (43%) had positive results by conventional PCR; of these, 89 (82%) also had positive results by real time PCR. There was a high prevalence of hypertension (64%) and overweight (body mass index [BMI]>25; 67%), with no difference by T. cruzi infection status. Nearly 60% of symptomatic congestive heart failure was attributed to Chagas cardiomyopathy; mortality was also higher for seropositive than seronegative patients (p = 0.05). In multivariable models, longer residence in an endemic province, residence in a rural area and poor housing conditions were associated with T. cruzi infection. Male sex, increasing age and poor housing were independent predictors of Chagas cardiomyopathy severity. Males and participants with BMI <= 25 had significantly higher likelihood of positive PCR results compared to females or overweight participants. Conclusions: Chagas cardiomyopathy remains an important cause of congestive heart failure in this hospital population, and should be evaluated in the context of the epidemiological transition that has increased risk of obesity, hypertension and chronic cardiovascular disease. C1 [Hidron, Alicia I.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. [Gilman, Robert H.; Galdos-Cardenas, Gerson] Asociac Benef PRISMA, Lima, Peru. [Gilman, Robert H.; Calderon, Martiza; Verastegui, Manuela; Valencia, Eduardo] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Lima, Peru. [Justiniano, Juan; LaFuente, Carlos; Selum, Walter; Ferrufino, Lisbeth] Hosp Univ Japones, Santa Cruz, Bolivia. [Blackstock, Anna J.; Bern, Caryn] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Blackstock, Anna J.] Atlanta Res & Educ Fdn, Decatur, GA USA. [Tornheim, Jeffrey A.] Mt Sinai Sch Med, New York, NY USA. [O'Neal, Seth] Oregon Hlth & Sci Univ, Portland, OR USA. [Comer, Robert] Wake Forest Univ Hlth Sci, Winston Salem, NC USA. RP Hidron, AI (reprint author), Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. EM CBern@cdc.gov FU National Institute of Allergy and Infectious Diseases, National Institutes of Health [NIH 5 P50 AI074285]; NIH [R24TW007988, T35 AI065385, D43 TW006581] FX Financial support was provided by the National Institute of Allergy and Infectious Diseases, National Institutes of Health - Peru TMRC Program Grant NIH 5 P50 AI074285; NIH Fogarty Scholars Program R24TW007988, NIH Training Grant in Infectious and Tropical Diseases 5 T35 AI065385, and NIH Global Research Training Grant D43 TW006581. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 22 Z9 22 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2010 VL 4 IS 5 AR e688 DI 10.1371/journal.pntd.0000688 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 608QO UT WOS:000278601000018 PM 20502520 ER PT J AU Kent, RJ Crabtree, MB Miller, BR AF Kent, Rebekah J. Crabtree, Mary B. Miller, Barry R. TI Transmission of West Nile Virus by Culex quinquefasciatus Say Infected with Culex Flavivirus Izabal SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID INSECT-SPECIFIC FLAVIVIRUS; AEDES-ALBOPICTUS CELLS; FUSING AGENT VIRUS; RNA INTERFERENCE; GENUS FLAVIVIRUS; DUAL INFECTIONS; SINDBIS VIRUS; BORNE VIRUSES; MOSQUITOS; AEGYPTI AB Background: The natural history and potential impact of mosquito-specific flaviviruses on the transmission efficiency of West Nile virus (WNV) is unknown. The objective of this study was to determine whether or not prior infection with Culex flavivirus (CxFV) Izabal altered the vector competence of Cx. quinquefasciatus Say for transmission of a co-circulating strain of West Nile virus (WNV) from Guatemala. Methods and Findings: CxFV-negative Culex quinquefasciatus and those infected with CxFV Izabal by intrathoracic inoculation were administered WNV-infectious blood meals. Infection, dissemination, and transmission of WNV were measured by plaque titration on Vero cells of individual mosquito bodies, legs, or saliva, respectively, two weeks following WNV exposure. Additional groups of Cx. quinquefasciatus were intrathoracically inoculated with WNV alone or WNV+CxFV Izabal simultaneously, and saliva collected nine days post inoculation. Growth of WNV in Aedes albopictus C6/36 cells or Cx. quinquefasciatus was not inhibited by prior infection with CxFV Izabal. There was no significant difference in the vector competence of Cx. quinquefasciatus for WNV between mosquitoes uninfected or infected with CxFV Izabal across multiple WNV blood meal titers and two colonies of Cx. quinquefasciatus (p>0.05). However, significantly more Cx. quinquefasciatus from Honduras that were co-inoculated simultaneously with both viruses transmitted WNV than those inoculated with WNV alone (p = 0.0014). Co-inoculated mosquitoes that transmitted WNV also contained CxFV in their saliva, whereas mosquitoes inoculated with CxFV alone did not contain virus in their saliva. Conclusions: In the sequential infection experiments, prior infection with CxFV Izabal had no significant impact on WNV replication, infection, dissemination, or transmission by Cx. quinquefasciatus, however WNV transmission was enhanced in the Honduras colony when mosquitoes were inoculated simultaneously with both viruses. C1 [Kent, Rebekah J.; Crabtree, Mary B.; Miller, Barry R.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Arbovirus Dis Branch, Ft Collins, CO USA. RP Kent, RJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Arbovirus Dis Branch, Ft Collins, CO USA. EM fxk7@cdc.gov RI Kading, Rebekah/E-5633-2017 OI Kading, Rebekah/0000-0002-4996-915X NR 46 TC 61 Z9 66 U1 1 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2010 VL 4 IS 5 AR e671 DI 10.1371/journal.pntd.0000671 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 608QO UT WOS:000278601000004 PM 20454569 ER PT J AU Hensley, LE Mulangu, S Asiedu, C Johnson, J Honko, AN Stanley, D Fabozzi, G Nichol, ST Ksiazek, TG Rollin, PE Wahl-Jensen, V Bailey, M Jahrling, PB Roederer, M Koup, RA Sullivan, NJ AF Hensley, Lisa E. Mulangu, Sabue Asiedu, Clement Johnson, Joshua Honko, Anna N. Stanley, Daphne Fabozzi, Giulia Nichol, Stuart T. Ksiazek, Thomas G. Rollin, Pierre E. Wahl-Jensen, Victoria Bailey, Michael Jahrling, Peter B. Roederer, Mario Koup, Richard A. Sullivan, Nancy J. TI Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species SO PLOS PATHOGENS LA English DT Article ID NONHUMAN-PRIMATES; RHESUS-MONKEYS; HEMORRHAGIC-FEVER; VIRUS INFECTION; CELL RESPONSES; T-LYMPHOCYTES; REPLICATION; VECTORS; GLYCOPROTEIN; GENERATION AB A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new outbreaks of previously undetected viruses. Ebolavirus (EBOV) vaccines have demonstrated protection against EBOV infection in nonhuman primates (NHP) and show promise in human clinical trials but immune protection occurs only with vaccines whose antigens are matched to the infectious challenge species. A 2007 hemorrhagic fever outbreak in Uganda demonstrated the existence of a new EBOV species, Bundibugyo (BEBOV), that differed from viruses covered by current vaccine candidates by up to 43% in genome sequence. To address the question of whether cross-protective immunity can be generated against this novel species, cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV. This report provides the first demonstration of vaccine-induced protective immunity against challenge with a heterologous EBOV species, and shows that Ebola vaccines capable of eliciting potent cellular immunity may provide the best strategy for eliciting cross-protection against newly emerging heterologous EBOV species. C1 [Hensley, Lisa E.; Johnson, Joshua; Honko, Anna N.; Wahl-Jensen, Victoria] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Mulangu, Sabue; Asiedu, Clement; Stanley, Daphne; Fabozzi, Giulia; Bailey, Michael; Sullivan, Nancy J.] NIAID, Biodef Res Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Nichol, Stuart T.; Ksiazek, Thomas G.; Rollin, Pierre E.] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Jahrling, Peter B.] NIAID, Integrated Res Facil, NIH, Bethesda, MD 20892 USA. [Roederer, Mario; Koup, Richard A.] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Hensley, LE (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM nsullivan@nih.gov OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU Vaccine Research Center, NIAID, National Institutes of Health FX This work was supported in part by the Intramural Research Program of the Vaccine Research Center, NIAID, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 60 Z9 62 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2010 VL 6 IS 5 AR e1000904 DI 10.1371/journal.ppat.1000904 PG 9 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 610TL UT WOS:000278759900023 PM 20502688 ER PT J AU Silverman, MN Heim, CM Nater, UM Marques, AH Sternberg, EM AF Silverman, Marni N. Heim, Christine M. Nater, Urs M. Marques, Andrea H. Sternberg, Esther M. TI Neuroendocrine and Immune Contributors to Fatigue SO PM&R LA English DT Article AB Central fatigue, a persistent and subjective sense of tiredness, generally correlates poorly with traditional markers of disease. It is frequently associated with psychosocial factors, such as depression, sleep disorder, anxiety, and coping style, which suggest that dysregulation of the body's stress systems may serve as an underlying mechanism in the maintenance of chronic fatigue (CF). This article addresses the endocrine, neural, and immune factors that contribute to fatigue and describes research regarding the role of these factors in chronic fatigue syndrome as a model for addressing the biology of CF. In general, hypoactivity of the hypothalamic-pituitary-adrenal axis, autonomic nervous system alterations characterized by sympathetic overactivity and low vagal tone, as well as immune abnormalities, may contribute to the expression of CF. Noninvasive methods for evaluating endocrine, neural, and immune function are also discussed. Simultaneous evaluation of neuroendocrine and immune systems with noninvasive techniques will help elucidate the underlying interactions of these systems, their role in disease susceptibility, and progression of stress-related disorders. PM R 2010;2:338-346 C1 [Sternberg, Esther M.] NIMH, Sect Neuroendocrine Immunol & Behav, NIH, Integrat Neural Immune Program, Rockville, MD 20852 USA. [Heim, Christine M.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA. [Nater, Urs M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nater, Urs M.] Univ Zurich, Dept Clin Psychol & Psychotherapy, CH-8006 Zurich, Switzerland. [Marques, Andrea H.] NIMH, Genet Epidemiol Branch, NIH, Bethesda, MD 20892 USA. RP Sternberg, EM (reprint author), NIMH, Sect Neuroendocrine Immunol & Behav, NIH, Integrat Neural Immune Program, 5625 Fishers Lane,MSC-9401, Rockville, MD 20852 USA. EM sternbee@mail.nih.gov RI Heim, Christine/A-1183-2009; Nater, Urs/J-6898-2013; OI Nater, Urs/0000-0002-2430-5090 FU NIH Intramural Research Funds; CeNeRx; NIH Intramural Research Funds, Department of Defense FX 8B, NIH Intramural Research Funds; 2A, CeNeRx consulting fee; 7A, Novartis; 8B, NIH, NARSAD, ADAA; 8B, NIH Intramural Research Funds, Department of Defense NR 109 TC 49 Z9 50 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 J9 PM&R JI PM&R PD MAY PY 2010 VL 2 IS 5 BP 338 EP 346 DI 10.1016/j.pmrj.2010.04.008 PG 9 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA V23SB UT WOS:000208361400005 PM 20656615 ER PT J AU Agarwal, R Norton, JM Konty, K Zimmerman, R Glover, M Lekiachvili, A McGruder, H Malarcher, A Casper, M Mensah, G Thorpe, L AF Agarwal, Reena Norton, Jennifer M. Konty, Kevin Zimmerman, Regina Glover, Maleeka Lekiachvili, Akaki McGruder, Henraya Malarcher, Ann Casper, Michele Mensah, George Thorpe, Lorna TI Overreporting of Deaths From Coronary Heart Disease in New York City Hospitals, 2003 SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction New York City has one of the highest reported death rates from coronary heart disease in the United States. We sought to measure the accuracy of this rate by examining death certificates. Methods We conducted a cross-sectional validation study by using a random sample of death certificates that recorded inhospital deaths in New York City from January through June 2003, stratified by neighborhoods with low, medium, and high coronary heart disease death rates. We abstracted data from hospital records, and an independent, blinded medical team reviewed these data to validate cause of death. We computed a comparability ratio (coronary heart disease deaths recorded on death certificates divided by validated coronary heart disease deaths) to quantify agreement between death certificate determination and clinical judgment. Results Of 491 sampled death certificates for in-hospital deaths, medical charts were abstracted and reviewed by the expert panel for 444 (90%). The comparability ratio for coronary heart disease deaths among decedents aged 35 to 74 years was 1.51, indicating that death certificates overestimated coronary heart disease deaths in this age group by 51%. The comparability ratio increased with age to 1.94 for decedents aged 75 to 84 years and to 2.37 for decedents aged 85 years or older. Conclusion Coronary heart disease appears to be substantially overreported as a cause of death in New York City among in-hospital deaths. C1 [Agarwal, Reena; Norton, Jennifer M.; Konty, Kevin; Zimmerman, Regina; Thorpe, Lorna] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Glover, Maleeka; Lekiachvili, Akaki; McGruder, Henraya; Malarcher, Ann; Casper, Michele; Mensah, George] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mensah, George] PepsiCo, Purchase, NY USA. [Thorpe, Lorna] CUNY Sch Publ Hlth, Hunter Coll, New York, NY USA. RP Agarwal, R (reprint author), Montefiore Med Ctr, Div Gen Internal Med, 111 E 210th St, Bronx, NY 10467 USA. EM ragarwal@montefiore.org FU Centers for Disease Control and Prevention, Epidemiology Program Office FX Data collection for this study was partially supported by the Centers for Disease Control and Prevention, Epidemiology Program Office. NR 12 TC 22 Z9 22 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A47 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600002 PM 20394686 ER PT J AU Bolen, J Schieb, L Hootman, JM Helmick, CG Theis, K Murphy, LB Langmaid, G AF Bolen, Julie Schieb, Linda Hootman, Jennifer M. Helmick, Charles G. Theis, Kristina Murphy, Louise B. Langmaid, Gary TI Differences in the Prevalence and Impact of Arthritis Among Racial/Ethnic Groups in the United States, National Health Interview Survey, 2002, 2003, and 2006 SO PREVENTING CHRONIC DISEASE LA English DT Article AB We describe the prevalence of doctor-diagnosed arthritis and its impact on activities, work, and joint pain for 6 racial/ethnic groups: non-Hispanic whites, non-Hispanic blacks, Hispanics, American Indians/Alaska Natives, Asians and Pacific Islanders, and multiracial or "other" respondents. We combined data from the 2002, 2003, and 2006 National Health Interview Survey (n = 85,784) and, after adjusting for age, sex, and body mass index, compared racial/ethnic differences. Arthritis-attributable activity limitation, arthritis-attributable work limitation, and severe joint pain were higher for non-Hispanic blacks, Hispanics, and multiracial or other respondents with arthritis compared with non-Hispanic whites with arthritis. Our finding that arthritis disproportionately affects certain racial/ethnic minorities may be useful for planning interventions. C1 [Bolen, Julie] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. [Langmaid, Gary] Northrop Grumman, Atlanta, GA USA. RP Bolen, J (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Hwy NE,Mailstop K-51, Atlanta, GA 30341 USA. EM JBolen@cdc.gov NR 12 TC 31 Z9 32 U1 2 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A64 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600019 PM 20394703 ER PT J AU Breslau, ES Rochester, PW Saslow, D Crocoll, CE Johnson, LE Vinson, CA AF Breslau, Erica S. Rochester, Phyllis W. Saslow, Debbie Crocoll, Caroline E. Johnson, Lenora E. Vinson, Cynthia A. TI Developing Partnerships to Reduce Disparities in Cancer Screening SO PREVENTING CHRONIC DISEASE LA English DT Article AB Background Interventions in scientific settings to improve the wellbeing of women who are not regularly screened for cancer have failed. Consequently, community-based prevention and control efforts are needed. Community Context From 2003 through 2007, three federal agencies and 1 nongovernmental agency collaborated with county-level public health counterparts from 6 states to address screening disparities in cervical and breast cancer in counties with the highest prevalence. This case study describes lessons learned from Team Up, a model pilot program. Methods We conducted a descriptive qualitative case study including 5 Southern states and 1 Midwestern state: Alabama, Georgia, Kentucky, Missouri, South Carolina, and Tennessee. The 6 states underwent a 5-step process to adopt, adapt, and implement 1 of 3 evidence-based interventions designed for cervical and breast cancer screening. Outcome The 6 participating states had various levels of success. Participating states formed and sustained viable interorganizational public health partnerships throughout the pilot program and beyond. Interpretation Although this innovative pilot faced many difficulties, participants overcame substantial obstacles and produced many key accomplishments. Team Up brought together 2 challenging public health strategies: the translation of evidence-based approaches to communities and populations, and partnerships among diverse people and organizations. Case study results suggest that using a mix of approaches can promote the transference of evidence from research into practice through local, regional, and national partnerships. C1 [Rochester, Phyllis W.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Saslow, Debbie] Amer Canc Soc, Atlanta, GA 30329 USA. [Crocoll, Caroline E.] USDA, Washington, DC 20250 USA. [Breslau, Erica S.; Johnson, Lenora E.; Vinson, Cynthia A.] NCI, Bethesda, MD 20850 USA. RP Breslau, ES (reprint author), NCI, 6130 Execut Blvd,Ste 4098, Bethesda, MD 20850 USA. EM breslaue@mail.nih.gov NR 25 TC 4 Z9 4 U1 2 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A62 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600017 PM 20394701 ER PT J AU Carlson, SA Brooks, JD Brown, DR Buchner, DM AF Carlson, Susan A. Brooks, Joseph D. Brown, David R. Buchner, David M. TI Racial/Ethnic Differences in Perceived Access, Environmental Barriers to Use, and Use of Community Parks SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction Community parks provide places for people to be physically active. Our objective was to determine how access to, barriers to use of, and use of community parks differ by race/ethnicity. Methods Analyses are based on a cross-sectional national sample of adults (N = 5,157) participating in the 2006 HealthStyles mail survey. Community parks were defined as outdoor public areas within 10 miles or a 20-minute drive from where a person lives that include walking/bike paths, nature preserves, playgrounds, beaches, lakes, rivers, or similar places. Results Overall, 12% of respondents reported not having a community park. Among those with a community park, 14% reported personal safety concerns and 14% reported inadequate or poorly maintained facilities as barriers to park use. Race/ethnicity was not associated with park access; however, Hispanics and non-Hispanic blacks were more likely than non-Hispanic whites to report barriers. Among those with access to a community park, 83% reported any park use in the previous year and, of these, 67% reported an active visit. Odds of any park use did not differ significantly by race/ethnicity. Odds of an active visit were significantly lower in non-Hispanic blacks than whites (odds ratio, 0.67) but did not significantly differ between Hispanics and non-Hispanic whites. Conclusions Parks are valuable community resources to all racial/ethnic groups. To promote and increase community park use, it is important to be aware that parks are used differently by different racial/ethnic groups and that barriers may differentially influence park use. C1 [Carlson, Susan A.; Brooks, Joseph D.; Brown, David R.; Buchner, David M.] Ctr Dis Control & Prevent, Atlanta, GA 30345 USA. RP Carlson, SA (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop K-46, Atlanta, GA 30345 USA. EM scarlson1@cdc.gov NR 26 TC 14 Z9 14 U1 1 U2 11 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A49 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600004 PM 20394688 ER PT J AU Dube, SR Cook, ML Edwards, VJ AF Dube, Shanta R. Cook, Michelle L. Edwards, Valerie J. TI Health-Related Outcomes of Adverse Childhood Experiences in Texas, 2002 SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction We assessed the prevalence of 7 childhood adversities (psychological, physical, and sexual abuse; household mental illness; household substance abuse; maternal battery; and incarceration of a household member) and the associations of those adversities with health outcomes. Methods Using data from 5,378 people who responded to the 2002 Texas Behavioral Risk Factor Surveillance System survey (which included questions about childhood adversity), we created 4 groups: no childhood abuse or household dysfunction, childhood abuse only, household dysfunction only, and both childhood abuse and household dysfunction. We examined groups by sociodemographic variables and the association with current smoking, obesity, and self-rated health. Results Among adult respondents, 46% reported at least 1 childhood adversity. Reports of both household dysfunction and abuse were significantly lower for college graduates than for people with less education. For those with both abuse and household dysfunction, the odds of current smoking were 1.9 and for obesity were 1.3. Compared to people without childhood adversities, people who experienced childhood adversities more frequently reported having fair or poor general health status. Conclusion Childhood adversities are common among Texas adults. People with childhood adversities are more likely to be socioeconomically disadvantaged, less educated, and have difficulties maintaining employment in adulthood compared to people with no adversities. Moreover, childhood adversities appear to be associated with health problems such as current smoking, obesity, and poor or fair general health among Texas adults. C1 [Dube, Shanta R.; Edwards, Valerie J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Cook, Michelle L.] Texas Dept State Hlth Serv, Ctr Hlth Stat, Austin, TX USA. RP Dube, SR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS K-50, Atlanta, GA 30341 USA. EM skd7@cdc.gov FU CDC [U58CCU602102, U58DP622789, U58DP001992, B01DP009053] FX This research was supported by grant and cooperative agreements U58CCU602102, U58DP622789, U58DP001992, and B01DP009053 from CDC. NR 33 TC 24 Z9 24 U1 2 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A52 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600007 PM 20394691 ER PT J AU Harris, CD Pan, LP Mukhtar, Q AF Harris, Carmen D. Pan, Liping Mukhtar, Qaiser TI Changes in Receiving Preventive Care Services Among US Adults With Diabetes, 1997-2007 SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction Diabetes is a chronic disease that requires complex continuing medical care and patient self-management to reduce the risk of long-term complications. Receipt of multiple recommended preventive care services can prevent or delay diabetes-related complications such as blindness and lower-extremity amputations. Methods We analyzed 1997 and 2007 Behavioral Risk Factor Surveillance System data to examine change in rates of adults with diabetes receiving 4 essential preventive care services (influenza and pneumococcal vaccinations and annual foot and eye examinations). Results The overall age-adjusted rate of receiving all 4 of the preventive care services was 10% in 1997 but increased to 20% in 2007. Rates for receiving all 4 services increased significantly in all demographic subgroups except Hispanics. Conclusion Use of preventive care services is increasing, but most US adults with diabetes do not meet recommendations, and the problem is particularly pronounced among Hispanics. The need to receive preventive care services should continue to be emphasized in clinical and community settings to increase the percentage of adults with diabetes who receive them. C1 [Harris, Carmen D.; Pan, Liping; Mukhtar, Qaiser] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Harris, CD (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop K-46, Atlanta, GA 30341 USA. EM charris2@cdc.gov NR 17 TC 4 Z9 4 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A56 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600011 PM 20394695 ER PT J AU Pathak, EB Casper, ML Tanner, JP Reader, S Ward, B AF Pathak, Elizabeth Barnett Casper, Michele L. Tanner, Jean Paul Reader, Steven Ward, Beverly TI A Multilevel Analysis of Absence of Transport to a Hospital Before Premature Cardiac Death SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction Prompt transportation to a hospital and aggressive medical treatment can often prevent acute cardiac events from becoming fatal. Consequently, lack of transport before death may represent lost opportunities for life-saving interventions. We investigated the effect of individual characteristics (age, sex, race/ethnicity, education, and marital status) and small-area factors (population density and social cohesion) on the probability of premature cardiac decedents dying without transport to a hospital. Methods We analyzed death data for adults aged 25 to 69 years who resided in the Tampa, Florida, metropolitan statistical area and died from an acute cardiac event from 1998 through 2002 (N = 2,570). Geocoding of decedent addresses allowed the use of multilevel (hierarchical) logistic regression models for analysis. Results The strongest predictor of dying without transport was being unmarried (odds ratio, 2.13; 95% confidence interval, 1.79-2.52, P < .001). There was no effect of education; however, white race was modestly predictive of dying without transport. Younger decedent age was a strong predictor. Multilevel statistical modeling revealed that less than 1% of the variance in our data was found at the small-area level. Conclusions Results contradicted our hypothesis that small-area characteristics would increase the probability of cardiac patients receiving transport before death. Instead we found that being unmarried, a proxy of living alone and perhaps low social support, was the most important predictor of people who died from a cardiac event dying without transport to a hospital. C1 [Pathak, Elizabeth Barnett] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL 33612 USA. [Casper, Michele L.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Pathak, EB (reprint author), Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, 13201 Bruce B Downs Blvd,MDC 56, Tampa, FL 33612 USA. EM epathak@health.usf.edu RI Pathak, Elizabeth/H-2683-2013 OI Pathak, Elizabeth/0000-0002-9702-0782 FU Centers for Disease Control and Prevention [S3026] FX This study was funded through a cooperative agreement (no. S3026) from the Centers for Disease Control and Prevention, administered through the Association of Schools of Public Health. The funding agency did not influence the study design, analyses, or interpretation of results. NR 32 TC 0 Z9 0 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2010 VL 7 IS 3 AR A59 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20SB UT WOS:000208158600014 PM 20394698 ER PT J AU Zhang, XP Geiss, LS Caspersen, CJ Cheng, YJ Engelgau, MM Johnson, JA Plotnikoff, RC Gregg, EW AF Zhang, Xuanping Geiss, Linda S. Caspersen, Carl J. Cheng, Yiling J. Engelgau, Michael M. Johnson, Jeffrey A. Plotnikoff, Ronald C. Gregg, Edward W. TI Physical activity levels and differences in the prevalence of diabetes between the United States and Canada SO PREVENTIVE MEDICINE LA English DT Article DE Physical activity; Prevalence of diabetes ID US ADULTS; INSULIN-RESISTANCE; HEALTH PROMOTION; GLYCEMIC CONTROL; RISK; POPULATION; PREVENTION; EXERCISE; PARTICIPATION; INTERVENTION AB Objective. To examine the American-Canadian difference in physical activity and its association with diabetes prevalence. Methods. We used cross-sectional data from nationally representative samples of adults (8688 persons aged 18 years) participating in the 2004 Joint Canada/U.S. Survey of Health. Using data on up to 22 activities in the past 3 months, we defined 3 physical activity groups (in metabolic equivalents-hours/day) as low (<1.5), moderate (1.5-2.9), and high (>= 3.0). We employed logistic regression models in our analyses. Results. Self-reported diabetes prevalence was 7.6% in the U.S. and 5.4% in Canada. The prevalence of low physical activity was considerably higher in the U.S. (70.9%) than in Canada (52.3%), while levels of moderate and high physical activity were higher in Canada (24.6% and 23.1%, respectively) than in the U.S. (14.3% and 14.8%, respectively). Using nationality (Canada as reference) to predict diabetes status, the adjusted odds ratio was 1.48 (95%CI, 1.22-1.79), and became 1.38 (95%CI, 1.15-1.66) when additionally adjusting for physical activity level. We estimate that 20.8% of the U.S.-Canada difference in diabetes prevalence is associated with physical activity. Conclusions. The difference in the prevalence of diabetes between U.S. and Canadian adults may be partially explained by differences in physical activity between the two countries. Published by Elsevier Inc. C1 [Zhang, Xuanping; Geiss, Linda S.; Caspersen, Carl J.; Cheng, Yiling J.; Gregg, Edward W.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. [Engelgau, Michael M.] World Bank, Washington, DC 20433 USA. [Johnson, Jeffrey A.; Plotnikoff, Ronald C.] Univ Alberta, Edmonton, AB T6G 2M7, Canada. [Plotnikoff, Ronald C.] Univ Newcastle, Callaghan, NSW 2308, Australia. RP Zhang, XP (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, MS K-10,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM xbz2@cdc.gov RI Caspersen, Carl/B-2494-2009 FU Centers for Disease Control and Prevention (CDC) FX This study was supported by the Centers for Disease Control and Prevention (CDC). NR 52 TC 12 Z9 12 U1 6 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD MAY-JUN PY 2010 VL 50 IS 5-6 BP 241 EP 245 DI 10.1016/j.ypmed.2010.02.015 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 600EL UT WOS:000277967300004 PM 20211199 ER PT J AU Dhingra, SS Zack, M Strine, T Pearson, WS Balluz, L AF Dhingra, Satvinder S. Zack, Matthew Strine, Tara Pearson, William S. Balluz, Lina TI Determining Prevalence and Correlates of Psychiatric Treatment With Andersen's Behavioral Model of Health Services Use SO PSYCHIATRIC SERVICES LA English DT Article ID COMORBIDITY SURVEY REPLICATION; UNITED-STATES; MENTAL-DISORDERS; MEDICAL-CARE; UNMET NEED; POPULATION; ILLNESS; ACCESS AB Objective: This study examined the prevalence and correlates of use of health professional services for the treatment of mental or emotional problems by using Andersen's Behavioral Model of Health Services Use. Methods: In the 2007 Behavioral Risk Factor Surveillance System 169,546 community-dwelling respondents from 35 states, the District of Columbia, and Puerto Rico answered questions about their sociodemographic characteristics; perceived need; nonspecific psychological distress, as measured with the Kessler-6 scale; and use of professional treatment of mental or emotional problems. Results: Evaluated need (psychological distress) was significantly associated with receipt of treatment for mental or emotional problems, as were predisposing factors (age, gender, race or ethnicity, marital status, and education), enabling and impeding factors (income, health insurance, and emotional support), and perceived need (number of mentally and physically unhealthy days and self-rated health). Conclusion: Constituents in the public mental health system should seriously consider that health services utilization is socially patterned and not just an individual behavior. (Psychiatric Services 61:524-528, 2010) C1 [Dhingra, Satvinder S.; Zack, Matthew; Strine, Tara; Pearson, William S.; Balluz, Lina] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. RP Dhingra, SS (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway,Mailstop K66, Atlanta, GA 30341 USA. EM sdhingra@cdc.gov NR 15 TC 29 Z9 29 U1 2 U2 12 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD MAY PY 2010 VL 61 IS 5 BP 524 EP 528 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 590SX UT WOS:000277249200020 PM 20439377 ER PT J AU Downes, FP Ridderhof, JC AF Downes, Frances Pouch Ridderhof, John C. TI THE EVOLVING PUBLIC HEALTH LABORATORY SYSTEM SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Downes, Frances Pouch] Michigan Dept Community Hlth, Lansing, MI 48909 USA. [Ridderhof, John C.] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. RP Downes, FP (reprint author), Michigan Dept Community Hlth, 3350 N Martin Luther King,Jr Blvd, Lansing, MI 48909 USA. EM downesf@michigan.gov NR 22 TC 4 Z9 4 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 SU 2 BP 1 EP 3 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WB UT WOS:000276554900001 PM 20521373 ER PT J AU Astles, JR White, VA Williams, LO AF Astles, J. Rex White, Vanessa A. Williams, Laurina O. TI Origins and Development of the National Laboratory System for Public Health Testing SO PUBLIC HEALTH REPORTS LA English DT Article ID UNITED-STATES; COMPLETENESS AB Although not recognized as such, a National Laboratory System (NLS) has existed since the inception of public health laboratory (PHL) testing more than a century ago. The NLS has always relied upon the participation of clinical laboratories, both to report test results that represent public health threats and to submit specimens and isolates to PHLs for additional or confirmatory testing. Historically, a number of factors have hindered the strengthening of the relationships between clinical laboratories and PHLs, but the reality of bioterrorism and subsequent focus on strengthening public-private relationships has stimulated the development of a more robust NLS. Since 2002, there has been substantial strengthening of the NLS through the sharing of lessons learned from several demonstration projects. There is a growing emphasis on defining critical elements of the NLS, including the State Public Health Laboratory System (SPH Laboratory System) and the functions of the Laboratory Program Advisor, a position that every state should have at the center of its laboratory system's capacity-building. Additional strengthening of the NLS is occurring through (1) national biennial measurement of state PHLs' abilities to meet the Core Functions and Capabilities of State PHLs, (2) the new Laboratory System Improvement Program (L-SIP) for the SPH Laboratory System, and (3) sharing ideas to integrate and improve the SPH Laboratory System (e.g., using the L-SIP Online Resource Center). Public health emergencies, such as the recent H1N1 epidemic, illustrate and reinforce the need for a strong NLS within which federal, public health, and clinical (i.e., hospital and private reference) laboratories function in close collaboration. C1 [Astles, J. Rex; Williams, Laurina O.] Ctr Dis Control & Prevent, Div Lab Syst, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [White, Vanessa A.] Assoc Publ Hlth Labs, Lab Syst & Stand, Silver Spring, MD USA. RP Astles, JR (reprint author), Ctr Dis Control & Prevent, Div Lab Syst, Natl Ctr Preparedness Detect & Control Infect Dis, MS G-25,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jda4@cdc.gov NR 49 TC 4 Z9 4 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 SU 2 BP 18 EP 30 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WB UT WOS:000276554900003 PM 20518442 ER PT J AU Wilcke, BW Inhorn, SL Astles, JR Su, B Wright, A White, VA AF Wilcke, Burton W., Jr. Inhorn, Stanley L. Astles, J. Rex Su, Bertina Wright, Abigail White, Vanessa A. TI Laboratory Services in Support of Public Health: A Status Report SO PUBLIC HEALTH REPORTS LA English DT Article AB Objectives. To assess Healthy People 2010 Objective 23-13 and its related sub-objectives measuring comprehensive laboratory services in support of essential public health programs, the Association of Public Health Laboratories (APHL) collaborated with the Centers for Disease Control and Prevention (CDC) to create and administer a survey of state public health laboratories (PHLs). Methods. A committee of APHL, with representation from CDC, constructed the survey based on the 11 Core Functions of State Public Health Laboratories (hereafter, Core Functions)-the premise being that the extent to which they fulfilled these Core Functions would represent their level of providing or assuring comprehensive laboratory services in support of public health. The survey was distributed biennially to all state health agencies from 2004 to 2008, and respondents were given two months to complete it. Results. The response rate for all surveys was >= 90.2%. State PHLs were more likely to meet the sub-objectives relating to traditional functions (e.g., disease surveillance and reference testing) than other areas (e.g., food safety and environmental testing). Emergency preparedness fell in between. Overall, but most notably in the areas of food safety and training and education, there was improvement from 2006 to 2008, with the percentage of respondents who met more than half of the sub-objectives increasing from 58.7% in 2006 to 61.2% in 2008. Conclusions. The comprehensive laboratory services survey has been a valuable tool in measuring the laboratory infrastructure that underpins public health in the U.S. It will be necessary to continue monitoring laboratory infrastructure in this way to determine where the gaps in services exist and how they can best be addressed. C1 [Wilcke, Burton W., Jr.] Univ Vermont, Dept Med Lab & Radiat Sci, Burlington, VT 05405 USA. [Inhorn, Stanley L.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. [Astles, J. Rex] Ctr Dis Control & Prevent, Div Lab Syst, Atlanta, GA USA. [Su, Bertina; White, Vanessa A.] Assoc Publ Hlth Labs, Lab Syst & Stand, Silver Spring, MD USA. [Wright, Abigail] Assoc Publ Hlth Labs, Strateg Initiat & Res, Silver Spring, MD USA. RP Wilcke, BW (reprint author), Univ Vermont, Dept Med Lab & Radiat Sci, 106 Carrigan Dr, Burlington, VT 05405 USA. EM burton.wilcke@uvm.edu FU Centers for Disease Control and Prevention (CDC) [CCU303019] FX This article was supported by cooperative agreement #CCU303019 from the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of CDC/the Agency for Toxic Substances and Disease Registry. NR 11 TC 5 Z9 5 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 SU 2 BP 40 EP 46 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WB UT WOS:000276554900005 PM 20518444 ER PT J AU Zarcone, P Nordenberg, D Meigs, M Merrick, U Jernigan, D Hinrichs, SH AF Zarcone, Patina Nordenberg, Dale Meigs, Michelle Merrick, Ulrike Jernigan, Daniel Hinrichs, Steven H. TI Community-Driven Standards-Based Electronic Laboratory Data-Sharing Networks SO PUBLIC HEALTH REPORTS LA English DT Article ID SYSTEM AB Public health laboratories (PHLs) are critical components of the nation's health-care system, serving as stewards of valuable specimens, delivering important diagnostic results to support clinical and public health programs, supporting public health policy, and conducting research. This article discusses the need for and challenges of creating standards-based data-sharing networks across the PHL community, which led to the development of the PHL Interoperability Project (PHLIP). Launched by the Association of Public Health Laboratories and the Centers for Disease Control and Prevention in September 2006, PHLIP has leveraged a unique community-based collaborative process, catalyzing national capabilities to more effectively share electronic laboratory-generated diagnostic information and bolster the nation's health security. PHLIP is emerging as a model of accelerated innovation for the fields of laboratory science, technology, and public health. C1 [Zarcone, Patina] Assoc Publ Hlth Labs, Strateg Initiat & Res, Silver Spring, MD 20910 USA. [Jernigan, Daniel] Ctr Dis Control & Prevent, Influenza Div, Coordinating Ctr Infect Dis, Atlanta, GA USA. [Hinrichs, Steven H.] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA. [Hinrichs, Steven H.] Nebraska Publ Hlth Lab, Omaha, NE USA. RP Zarcone, P (reprint author), Assoc Publ Hlth Labs, Strateg Initiat & Res, 8515 Georgia Ave,Ste 700, Silver Spring, MD 20910 USA. EM patina.zarcone@aphl.org FU Centers for Disease Control and Prevention (CDC) [CCU303019] FX This article was supported by cooperative agreement #CCU303019 from the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of CDC or the Agency for Toxic Substances and Disease Registry. NR 10 TC 4 Z9 4 U1 2 U2 4 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 SU 2 BP 47 EP 56 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WB UT WOS:000276554900006 PM 20521375 ER PT J AU Saydah, S Lochner, K AF Saydah, Sharon Lochner, Kimberly TI Socioeconomic Status and Risk of Diabetes-Related Mortality in the US SO PUBLIC HEALTH REPORTS LA English DT Article ID SELF-REPORTED HEIGHT; BODY-MASS INDEX; DEATH CERTIFICATES; NATIONAL-HEALTH; EDUCATION; VALIDITY; WEIGHT AB Objective. We examined disparities in diabetes-related mortality for socioeconomic status (SES) groups in nationally representative U.S. samples. Methods. We analyzed National Health Interview Survey respondents linked to their death records and included those eligible for mortality follow-up who were aged 25 years and older at the time of interview and not missing information on covariates (n=527,426). We measured SES by education and family income. There were 5,613 diabetes-related deaths. Results. Having less than a high school education was associated with a twofold higher mortality from diabetes, after controlling for age, gender, race/ethnicity, marital status, and body mass index, compared with adults with a college degree or higher education level (relative hazard [RH] = 2.05, 95% confidence interval [Cl] 1.78, 2.35). Having a family income below poverty level was associated with a twofold higher mortality after adjustments compared with adults with the highest family incomes (RH=2.41, 95% Cl 2.05, 2.84), Approximately one-quarter of the excess risk among those in the lowest SES categories was explained by adjusting for potential confounders. Conclusion. Findings from this nationally representative cohort demonstrate a socioeconomic gradient in diabetes-related mortality, with both education and income being important determinants of the risk of death. C1 [Saydah, Sharon] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Hyattsville, MD 20782 USA. [Lochner, Kimberly] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Off Anal & Epidemiol, Hyattsville, MD 20782 USA. RP Saydah, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM ssaydah@cdc.gov NR 31 TC 60 Z9 60 U1 1 U2 9 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 IS 3 BP 377 EP 388 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WD UT WOS:000276555100006 PM 20433032 ER PT J AU Wise, M Finelli, L Sorvillo, F AF Wise, Matthew Finelli, Lyn Sorvillo, Frank TI Prognostic Factors Associated with Hepatitis C Disease: A Case-Control Study Utilizing US Multiple-Cause-of-Death Data SO PUBLIC HEALTH REPORTS LA English DT Article ID VIRUS-INFECTION; UNITED-STATES; LIVER-DISEASE; DRUG-USERS; COINFECTION; PROGRESSION; MORTALITY; ALCOHOL; HIV; HEPATOTOXICITY AB Objectives. Hepatitis C, an important cause of premature mortality, is the most common chronic bloodborne infection in the United States. The severity of disease is strongly affected by a number of other medical conditions and health behaviors. We sought to estimate the association of several exposures with hepatitis C on death certificates. Methods. We enrolled 63,189 hepatitis C deaths as cases in a case-control study using multiple-cause-of-death data for the U.S. from 1999 to 2004. Three control groups were assembled from all remaining deaths with no mention of hepatitis C, including a random sample of all deaths, digestive disease deaths, and circulatory disease deaths. Results. Hepatitis B, human immunodeficiency virus (HIV), hemochromatosis, and alcohol use were all strongly associated with hepatitis C, even after controlling for confounding variables. The simultaneous presence of many of these exposures had a synergistic association with hepatitis C being listed as a cause of death. Hepatitis B, HIV, and alcohol use were recorded among 6.4%, 10.5%, and 18.2% of case deaths, respectively. Conclusions. The strong association of alcohol use, HIV, and hepatitis B with hepatitis C, as well as the frequent occurrence of these conditions, indicates that targeted interventions for mitigating the potential effect of these exposures may present an efficient means of limiting progression of hepatitis C-related liver disease and reducing the population burden of hepatitis C mortality. C1 [Wise, Matthew] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Wise, Matthew; Sorvillo, Frank] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. [Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Sorvillo, Frank] Los Angeles Dept Publ Hlth, Off Hlth Assessment & Epidemiol, Los Angeles, CA USA. RP Wise, M (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A-35, Atlanta, GA 30333 USA. EM cxx4@cdc.gov FU National Institutes of Health [T32AI07481] FX This project was supported by the National Institutes of Health, National Institute of Allergy and Infectious Diseases Training Program in HIV/AIDS Epidemiology (T32AI07481). The findings and conclusions in this article arc those of the authors and do not necessarily represent the views or the Centers for Disease Control and Prevention or the funding agency. NR 39 TC 8 Z9 9 U1 0 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 IS 3 BP 414 EP 422 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WD UT WOS:000276555100010 PM 20433036 ER PT J AU Iqbal, S Clower, JH Boehmer, TK Yip, FY Garbe, P AF Iqbal, Shahed Clower, Jacquelyn H. Boehmer, Tegan K. Yip, Fuyuen Y. Garbe, Paul TI Carbon Monoxide-Related Hospitalizations in the US: Evaluation of a Web-Based Query System for Public Health Surveillance SO PUBLIC HEALTH REPORTS LA English DT Article ID UNITED-STATES AB Objective. Carbon monoxide (CO) poisoning is preventable, yet it remains one of the most common causes of poisoning in the U.S. In the absence of a national data reporting system for CO-poisoning surveillance, the burden of CO-related hospitalizations is unknown. Our objective was to generate the first national estimates of CO-related hospitalizations and to evaluate the use of a Web-based query system for public health surveillance. Methods. The Healthcare Cost and Utilization Project's (HCUP's) 2005 Nationwide Inpatient Sample (NIS) data were used for CO-related hospitalization estimates. Data for confirmed, probable, and suspected cases were generated using the HCUPnet Web-based query system. We used data from 1993 through 2005 NIS to describe trends in CO-related hospitalizations. We used the Centers for Disease Control and Prevention's surveillance evaluation guidelines to evaluate the system. Results. In 2005, there were 24,891 CO-related hospitalizations nationwide: 16.9% (n=4,216) were confirmed, 1.1% (n=279) were probable, and 81.9% (n=20,396) were suspected CO-poisoning cases. Of the confirmed cases (1.42/100,000 population), the highest hospitalization rates occurred among males, older adults (aged >= 85 years), and Midwestern residents. CO-related hospitalization rates declined from 1993 through 2000 and plateaued from 2001 through 2005. The simplicity, acceptability, sensitivity, and representativeness of the HCUPnet surveillance system were excellent. However, HCUPnet showed limited flexibility and specificity. Conclusions. Nationwide, the burden of CO exposure resulting in hospitalization is substantial. HCUPnet is a useful surveillance tool that efficiently characterized CO-related hospitalizations for the first time. Public health practitioners can utilize this data source for state-level surveillance. C1 [Iqbal, Shahed] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Clower, Jacquelyn H.] Ctr Dis Control & Prevent, TKC Integrat Serv, Air Pollut & Resp Hlth Branch, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Iqbal, S (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Air Pollut & Resp Hlth Branch, Natl Ctr Environm Hlth,Div Environm Hazards & Hlt, 4770 Buford Hwy NE,MS F-58, Chamblee, GA 30341 USA. EM SIqbal@cdc.gov NR 36 TC 11 Z9 12 U1 0 U2 3 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 IS 3 BP 423 EP 432 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WD UT WOS:000276555100011 PM 20433037 ER PT J AU Cardenas, VM Mena, KD Ortiz, M Karri, S Variyam, E Behravesh, CB Snowden, KF Flisser, A Bristol, JR Mayberry, LF Ortega, YR Fukuda, Y Campos, A Graham, DY AF Cardenas, Victor M. Mena, Kristina D. Ortiz, Melchor Karri, Sitrulasi Variyam, Easwaran Behravesh, Casey Barton Snowden, Karen F. Flisser, Ana Bristol, John R. Mayberry, Lillian F. Ortega, Ynes R. Fukuda, Yoshihiro Campos, Armando Graham, David Y. TI Hyperendemic H. pylori and Tapeworm Infections in a US-Mexico Border Population SO PUBLIC HEALTH REPORTS LA English DT Article ID UNITED-STATES; INTESTINAL PARASITES; CHILDREN; CRYPTOSPORIDIUM AB Objective. A higher incidence of infectious disease has been documented in U.S. regions bordering Mexico compared with non-border areas. We assessed the prevalence of important gastrointestinal infections in Ciudad Juarez, Mexico, and El Paso, Texas, the largest binational community along the U.S.-Mexico border. Methods. Fecal specimens from a sample of the asymptomatic population representing all ages were tested for Helicobacter pylori (H. pylori), Cryptosporidium spp., Giardia spp., and other intestinal parasitic pathogens using flotation, immunoassays, and/or polymerase chain reaction. We also measured indicators of microbiological contamination of drinking water, hands of food preparers, and kitchen surfaces. Results. Overall, of the 386 participants, H. pylon was present in 38.2%, Taenia spp. in 3.3%, Giardia spp. in 2.7%, Cryptosporidium spp. in 1.9%, Entamoeba dispar in 1.3%, and Ascaris lumbricoides and Necator americanus in 0.3% of the study subjects; Cyclospora spp. and Entamoeba histolytica were not found. H. pylon infection was associated with handwashing (prevalence ratio [PR] = 1.3, 95% confidence interval [Cl] 1.0, 1.8). Taenia spp. was found more often on the U.S. side (PR=8.6, 95% Cl 2.3, 30.8). We did not find an association between these infections and the occurrence of total coliforms or fecal coliforms on kitchen surfaces. In addition, Escherichia coli was not found in any drinking water sample. Conclusion. The study results indicated that H. pylon and Taenia spp. infections may be highly prevalent along the U.S.-Mexico border. Additional research is necessary to adequately characterize the prevalence, as well as determine whether interventions that reduce these infections are warranted. C1 [Cardenas, Victor M.; Mena, Kristina D.; Ortiz, Melchor; Behravesh, Casey Barton; Bristol, John R.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, El Paso, TX 79902 USA. [Karri, Sitrulasi; Variyam, Easwaran] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Lubbock, TX 79430 USA. [Behravesh, Casey Barton] Texas A&M Univ, College Stn, TX USA. [Behravesh, Casey Barton] Ctr Dis Control & Prevent, Foodborne & Diarrheal Dis Branch, Atlanta, GA USA. [Snowden, Karen F.; Flisser, Ana] Univ Nacl Autonoma Mexico, Sch Med, Mexico City 04510, DF, Mexico. [Bristol, John R.; Mayberry, Lillian F.] Univ Texas El Paso, El Paso, TX 79968 USA. [Ortega, Ynes R.] Univ Georgia, Ctr Food Safety, Coll Agr & Environm Sci, Griffin, GA USA. [Fukuda, Yoshihiro] Hyogo Coll Med, Nishinomiya, Hyogo, Japan. [Campos, Armando] Inst Mexicano Seguro Social, Med Res Unit, Mexico City, DF, Mexico. [Graham, David Y.] Baylor Coll Med, Houston, TX 77030 USA. RP Cardenas, VM (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, El Paso Reg Campus,1100 N Stanton Ave, El Paso, TX 79902 USA. EM victor.cardenas@uth.tmc.edu RI Snowden, Karen/C-9111-2013 FU Paso net Norte Health Foundation's Center [004288] FX The authors acknowledge the financial support of the Paso net Norte Health Foundation's Center for Border Health Research Grant (CBHR EMS Project. 004288). The work was supported in part by the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, Public Health Service grant DK56338, which funds the Texas Gulf Coast Digestive Diseases Center. Dr. Variyam's laboratory is supported by institutional funds (Haggerton Chair in Gastroenterology and Dean's Research funds) and by the CH Foundation. The authors thank the following individuals for their assistance in data collection: Dolores Perez, Maria Concepcion Lopez, Mario Escobedo, Fernando Quiroz, and Martha Macias. NR 22 TC 6 Z9 6 U1 4 U2 11 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2010 VL 125 IS 3 BP 441 EP 447 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 581WD UT WOS:000276555100013 PM 20433039 ER PT J AU Roberge, RJ Coca, A Williams, WJ Powell, JB Palmiero, AJ AF Roberge, Raymond J. Coca, Aitor Williams, W. Jon Powell, Jeffrey B. Palmiero, Andrew J. TI Physiological Impact of the N95 Filtering Facepiece Respirator on Healthcare Workers SO RESPIRATORY CARE LA English DT Article DE N95 filtering facepiece; respirator; physiological; healthcare workers; comfort; exertion; Occupational Safety and Health Administration; workplace ID INDUCTIVE PLETHYSMOGRAPH; TRANSCUTANEOUS OXYGEN; GAS-EXCHANGE; EXERCISE; VENTILATION; PROTECTION; MASKS; RESPONSES; VALIDITY; DISEASE AB OBJECTIVE: To assess the physiological impact of the N95 filtering facepiece respirator (FFR) on healthcare workers. METHODS: Ten healthcare workers each conducted multiple 1-hour treadmill walking sessions, at 1.7 miles/h, and at 2.5 miles/h, while wearing FFR with exhalation valve, FFR without exhalation valve, and without FFR (control session). We monitored heart rate, respiratory rate, tidal volume, minute volume, blood oxygen saturation, and transcutaneously measured P(CO2). We also measured user comfort and exertion, FUR moisture retention, and the carbon dioxide and oxygen concentrations in the FFR's dead space. RESULTS: There were no significant differences between FFR and control in the physiological variables, exertion scores, or comfort scores. There was no significant difference in moisture retention between FFR with and without exhalation valve. Two subjects had peak P(CO2) >= 50 mm Hg. The FFR with exhalation valve offered no benefit in physiological burden over the FFR without valve. The FFR dead-space oxygen and carbon dioxide levels did not meet the Occupational Safety and Health Administration's ambient workplace standards. CONCLUSIONS: In healthy healthcare workers, FFR did not impose any important physiological burden during I hour of use, at realistic clinical work rates, but the FFR dead-space carbon dioxide and oxygen levels were significantly above and below, respectively, the ambient workplace standards, and elevated P(CO2) is a possibility. Exhalation valve did not significantly ameliorate the FFR's P(CO2) impact. C1 [Roberge, Raymond J.; Coca, Aitor; Williams, W. Jon; Powell, Jeffrey B.; Palmiero, Andrew J.] Ctr Dis Control & Prevent, Technol Res Branch, Natl Personal Protect Technol Lab, NIOSH, Pittsburgh, PA 15236 USA. RP Roberge, RJ (reprint author), Ctr Dis Control & Prevent, Technol Res Branch, Natl Personal Protect Technol Lab, NIOSH, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov NR 37 TC 35 Z9 35 U1 1 U2 1 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD MAY PY 2010 VL 55 IS 5 BP 569 EP 577 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 599TK UT WOS:000277936100006 PM 20420727 ER PT J AU Lobue, P Menzies, D AF Lobue, Philip Menzies, Dick TI Treatment of latent tuberculosis infection: An update SO RESPIROLOGY LA English DT Review DE isoniazid; latent; rifampin; prevention; tuberculosis ID ISONIAZID PREVENTIVE THERAPY; COST-EFFECTIVENESS ANALYSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; MULTIDRUG-RESISTANT TUBERCULOSIS; RANDOMIZED CONTROLLED-TRIAL; MULTICENTER CLINICAL-TRIAL; SOUTHEAST-ASIAN REFUGEES; SHORT-COURSE RIFAMPIN; UNITED-STATES; PULMONARY TUBERCULOSIS AB Isoniazid (INH) has been the mainstay of treatment of latent tuberculosis infection for almost 50 years. The currently recommended preferred regimen is 9 months daily self-administered INH (9H); this has efficacy of more than 90% if completed properly. Unfortunately, INH is associated with serious adverse events, including hepatotoxicity. Although risk factors for this complication are well established, allowing for better selection of candidates for therapy, this complication still occurs, and is occasionally fatal. Hence close follow up of patients is necessary, increasing the cost and complexity of treatment. This problem, plus the lengthy duration, results in poor acceptance by patients and providers, and poor adherence by patients. As a result, many preventable cases of tuberculosis continue to occur, and the public health impact of latent tuberculosis infection treatment is suboptimal. These problems have spurred interest in finding shorter, safer and cheaper alternative regimens, with similar efficacy. Of the many regimens that have been examined, 2 months of rifampin and pyrazinamide has excellent efficacy-in experimental studies in mice and randomized trials, largely in HIV-infected persons. However, while the safety of 2 months of rifampin and pyrazinamide appears acceptable in HIV-infected persons and children, in non-HIV-infected adults this regimen is associated with an unacceptably high rate of severe liver toxicity. Three to four months of INH and rifampin has had equivalent effectiveness as 6 months INH in several randomized trials. However, completion of therapy and toxicity has been the same as with INH-possibly because two drugs are taken rather than one. The fourth commonly studied regimen is 4 months rifampin. This has been found to have significantly better completion than 9H, with significantly less toxicity, especially hepatotoxicity. However, only one trial has evaluated efficacy and effectiveness of mono-rifampin therapy. In this trial, 3 months rifampin had somewhat better efficacy than either 3 months of isoniazid and rifampin (3HR) or 6 months isoniazid. Two large scale trials are ongoing; one is comparing efficacy and effectiveness of 9H with 4 months rifampin (both daily and self-administered), while the second, which is nearing completion, compares daily self-administered 9H with 3 months directly observed once weekly INH combined with rifapentine. The results of these two trials will likely shape future recommendations substantially. C1 [Lobue, Philip] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Menzies, Dick] McGill Univ, Montreal Chest Inst, Montreal, PQ, Canada. RP Lobue, P (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Mail Stop E-10,1600 Clifton Rd, Atlanta, GA 30333 USA. EM plobue@cdc.gov NR 156 TC 68 Z9 71 U1 3 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1323-7799 J9 RESPIROLOGY JI Respirology PD MAY PY 2010 VL 15 IS 4 BP 603 EP 622 DI 10.1111/j.1440-1843.2010.01751.x PG 20 WC Respiratory System SC Respiratory System GA 589RA UT WOS:000277169300005 PM 20409026 ER PT J AU Owusu-Edusei, K Gift, TL Chesson, HW AF Owusu-Edusei, Kwame, Jr. Gift, Thomas L. Chesson, Harrell W. TI Treatment Cost of Acute Gonococcal Infections: Estimates From Employer-Sponsored Private Insurance Claims Data in the United States, 2003-2007 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID PELVIC-INFLAMMATORY-DISEASE; SEXUALLY-TRANSMITTED-DISEASES; HIV-INFECTION; FERTILITY; WOMEN AB We used 2003-2007 claims data to estimate the direct cost of medical care per case of acute gonorrhea infection. The estimated average total cost per episode for those who were treated was $210 (male, $227; female, $205). This estimate does not include intangible (e. g., pain) and indirect costs (e. g., lost productivity). C1 [Owusu-Edusei, Kwame, Jr.; Gift, Thomas L.; Chesson, Harrell W.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Owusu-Edusei, K (reprint author), 1600 Clifton Rd,MSE 80, Atlanta, GA 30333 USA. EM Kowusuedusei@cdc.gov NR 17 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAY PY 2010 VL 37 IS 5 BP 316 EP 318 DI 10.1097/OLQ.0b013e3181c5e643 PG 3 WC Infectious Diseases SC Infectious Diseases GA 590ID UT WOS:000277217800008 PM 20216479 ER PT J AU Marks, G Millett, GA Bingham, T Lauby, J Murrill, CS Stueve, A AF Marks, Gary Millett, Gregorio A. Bingham, Trista Lauby, Jennifer Murrill, Christopher S. Stueve, Ann TI Prevalence and Protective Value of Serosorting and Strategic Positioning Among Black and Latino Men Who Have Sex With Men SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID UNPROTECTED ANAL INTERCOURSE; HIV-INFECTION; RISK; TRANSMISSION; BEHAVIORS; HIV/AIDS AB Self-reported HIV-negative black and Latino MSM who engaged in serosorting or strategic positioning were less likely to have unrecognized HIV infection than men who engaged in unprotected anal intercourse without using these risk-reduction strategies. C1 [Marks, Gary; Millett, Gregorio A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Bingham, Trista] Los Angeles Cty Dept Publ Hlth, HIV Epidemiol Program, Los Angeles, CA USA. [Lauby, Jennifer] Philadelphia Hlth Management Corp, Philadelphia, PA USA. [Murrill, Christopher S.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Stueve, Ann] Educ Dev Ctr Inc, New York, NY USA. RP Marks, G (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd,MS E-45, Atlanta, GA 30333 USA. EM gmarks@cdc.gov NR 18 TC 34 Z9 34 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAY PY 2010 VL 37 IS 5 BP 325 EP 327 DI 10.1097/OLQ.0b013e3181c95dac PG 3 WC Infectious Diseases SC Infectious Diseases GA 590ID UT WOS:000277217800010 PM 20081556 ER PT J AU Kronk, R Bishop, EE Raspa, M Bickel, JO Mandel, DA Bailey, DB AF Kronk, Rebecca Bishop, Ellen E. Raspa, Melissa Bickel, Julie O. Mandel, Daniel A. Bailey, Donald B., Jr. TI Prevalence, Nature, and Correlates of Sleep Problems Among Children with Fragile X Syndrome Based on a Large Scale Parent Survey SO SLEEP LA English DT Article DE Sleep; Fragile X syndrome; survey ID ASSIGNING ICF CODES; DEVELOPMENTAL-DISABILITIES; INTELLECTUAL DISABILITY; SYNAPTIC PLASTICITY; ANGELMAN-SYNDROME; DISORDERS; MELATONIN; PATTERNS; AUTISM; BEHAVIOR AB Study Objectives: This study reports on current child sleep difficulties reported by parents of children with Fragile X syndrome (FXS). We address prevalence and type of sleep problems (e.g., difficulty falling asleep, frequent awakenings); type and effectiveness of medical and behavioral treatments (e.g., medication, surgery, environmental changes); and explore specific child and family characteristics (e.g., child age, child gender, co-occurring conditions) as possible predictors of child sleep difficulties. Design/Participants: This study is part of a larger survey addressing needs of families with children with FXS. This article focuses on the families who responded to the survey sleep questions, had one or more children with the full mutation FXS, and who reside in the United States. The mean age for male and female children in this group was 15 years and 16 years respectively (N = 1,295). Results: Parents reported that 32% of the children with FXS currently experience sleep difficulties; 84% of those children are reported to have >= 2 current sleep problems. Problems falling asleep and frequent night awakenings were the most frequently reported difficulties; 47% of males and 40% of females received >= 1medication to help with sleep. Children with more problematic health or behavioral characteristics had a higher likelihood of having current sleep problems. Conclusions: Our survey provides the most representative sample to date of sleep problems in children with FXS or any other neurodevelopmental disability. This large scale survey establishes a foundation for the prevalence of sleep disorders in children with FXS. C1 [Kronk, Rebecca] Univ Pittsburgh, Childrens Hosp Pittsburgh, UPMC, UCLID Ctr,Child Dev Unit,Fragile Ctr 10, Pittsburgh, PA 15201 USA. [Bishop, Ellen E.; Raspa, Melissa; Bailey, Donald B., Jr.] RTI Int, Res Triangle Pk, NC USA. [Bickel, Julie O.] Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA. [Mandel, Daniel A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Mandel, Daniel A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Kronk, R (reprint author), Univ Pittsburgh, Childrens Hosp Pittsburgh, UPMC, UCLID Ctr,Child Dev Unit,Fragile Ctr 10, 45th & Penn, Pittsburgh, PA 15201 USA. EM becky.kronk@chp.edu OI Kronk, Rebecca/0000-0001-5209-7180 FU Centers for Disease Control and Prevention (CDC); Association for Prevention Teaching and Research (APTR) [U50/CCU300860, TS-1380] FX Preparation of this article was supported in part by the Centers for Disease Control and Prevention (CDC) and the Association for Prevention Teaching and Research (APTR) Cooperative Agreement No. U50/CCU300860, Project TS-1380. NR 53 TC 30 Z9 30 U1 2 U2 14 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD MAY 1 PY 2010 VL 33 IS 5 BP 679 EP 687 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 590NC UT WOS:000277232200015 PM 20469810 ER PT J AU Tong, X Kuklina, EV Gillespie, C George, MG AF Tong, Xin Kuklina, Elena V. Gillespie, Cathleen George, Mary G. TI Medical Complications Among Hospitalizations for Ischemic Stroke in the United States From 1998 to 2007 SO STROKE LA English DT Article DE cerebral infarct; embolism; epidemiology; outcomes; stroke care; venous thrombosis ID QUALITY-OF-CARE; INTERDISCIPLINARY WORKING GROUPS; PERIPHERAL-VASCULAR-DISEASE; MYOCARDIAL-INFARCTION; RISK-FACTORS; MORTALITY; TRENDS; GUIDELINES; MANAGEMENT; OUTCOMES AB Background and Purpose-The common medical complications after ischemic stroke are associated with increased mortality and resource use. Method-The study population consisted of 1 150 336 adult hospitalizations with ischemic stroke as a primary diagnosis included in the 1998 to 2007 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project. Multiple logistic regression analyses were used to examine changes between 1998 to 1999 and 2006 to 2007 in the prevalence of acute myocardial infarction, pneumonia, deep venous thrombosis, pulmonary embolism, or urinary tract infection, in-hospital mortality, and length of stay. Results-In 2006 to 2007, the prevalence of hospitalizations with a secondary diagnosis of acute myocardial infarction, pneumonia, deep venous thrombosis, pulmonary embolism, and urinary tract infection was 1.6%, 2.9%, 0.8%, 0.3%, and 10.1%, respectively. The adjusted ORs for a hospitalization in 2006 to 2007 complicated by acute myocardial infarction, deep venous thrombosis, pulmonary embolism, or urinary tract infection, using 1998 to 1999 as the referent, were 1.39, 1.68, 2.39, and 1.18, respectively. The odds of pneumonia did not change significantly between 1998 to 1999 and 2006 to 2007. In-hospital mortality was significantly lower in 2006 to 2007 than in 1998 to 1999. Despite the overall length of stay decreasing significantly from 1998 to 1999 to 2006 to 2007, it remained the same for hospitalizations with acute myocardial infarction, pneumonia, deep vein thrombosis, and pulmonary embolism. Conclusion-Although in-hospital mortality decreased over the study period, 4 of the 5 complications were more common in 2006 to 2007 than they were 8 years earlier with the largest increase observed for deep venous thrombosis and pulmonary embolism. (Stroke. 2010;41:980-986.) C1 [Tong, Xin; Kuklina, Elena V.; Gillespie, Cathleen; George, Mary G.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kuklina, EV (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS-K47, Atlanta, GA 30341 USA. EM ekuklina@cdc.gov NR 27 TC 24 Z9 26 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD MAY PY 2010 VL 41 IS 5 BP 980 EP 986 DI 10.1161/STROKEAHA.110.578674 PG 7 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 588IY UT WOS:000277064300025 PM 20203317 ER PT J AU Backer, LC McNeel, SV Barber, T Kirkpatrick, B Williams, C Irvin, M Zhou, Y Johnson, TB Nierenberg, K Aubel, M LePrell, R Chapman, A Foss, A Corum, S Hill, VR Kieszak, SM Cheng, YS AF Backer, Lorraine C. McNeel, Sandra V. Barber, Terry Kirkpatrick, Barbara Williams, Christopher Irvin, Mitch Zhou, Yue Johnson, Trisha B. Nierenberg, Kate Aubel, Mark LePrell, Rebecca Chapman, Andrew Foss, Amanda Corum, Susan Hill, Vincent R. Kieszak, Stephanie M. Cheng, Yung-Sung TI Recreational exposure to microcystins during algal blooms in two California lakes SO TOXICON LA English DT Article DE Aerosol exposures; Blue-green algae; Cyanobacteria; Microcystins; Microcystis aeruginosa; Waterborne exposures ID BLUE-GREEN-ALGAE; AEROSOLIZED BREVETOXINS; BIOLOGICAL EVIDENCE; HUMAN FATALITIES; HEALTH-RISKS; CYANOBACTERIA; WATER; BRAZIL; LIVER; ASTHMA AB We conducted a study of recreational exposure to microcystins among 81 children and adults planning recreational activities on either of three California reservoirs, two with significant, ongoing blooms of toxin-producing cyanobacteria, including Microcystis aeruginosa (Bloom Lakes), and one without a toxin-producing algal bloom (Control Lake). We analyzed water samples for algal taxonomy, microcystin concentrations, and potential respiratory viruses (adenoviruses and enteroviruses). We measured microcystins in personal air samples, nasal swabs, and blood samples. We interviewed study participants for demographic and health symptoms information. We found highly variable microcystin concentrations in Bloom Lakes (<10 mu g/L to >500 mu g/L); microcystin was not detected in the Control Lake. We did not detect adenoviruses or enteroviruses in any of the lakes. Low microcystin concentrations were found in personal air samples (<0.1 ng/m(3) [limit of detection]-2.89 ng/m(3)) and nasal swabs (<0.1 ng [limit of detection]-5 ng). Microcystin concentrations in the water-soluble fraction of all plasma samples were below the limit of detection (1.0 mu g/L). Our findings indicate that recreational activities in water bodies that experience toxin-producing cyanobacterial blooms can generate aerosolized cyanotoxins, making inhalation a potential route of exposure. Future studies should include collecting nasal swabs to assess upper respiratory tract deposition of toxin-containing aerosols droplets. Published by Elsevier Ltd. C1 [Backer, Lorraine C.; Kieszak, Stephanie M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [McNeel, Sandra V.] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA 94804 USA. [Barber, Terry] Siskiyou Cty Dept Publ Hlth & Community Dev, Yreka, CA 96097 USA. [Kirkpatrick, Barbara; Nierenberg, Kate] Mote Marine Lab, Sarasota, FL 34236 USA. [Williams, Christopher; Aubel, Mark; Chapman, Andrew; Foss, Amanda] GreenWater Labs, Palatka, FL 32177 USA. [Irvin, Mitch; Zhou, Yue; Cheng, Yung-Sung] Lovelace Resp Res Inst, Inhalat Toxicol Lab, Albuquerque, NM 87285 USA. [Johnson, Trisha B.; Hill, Vincent R.] Ctr Dis Control & Prevent, Ctr Infect Dis, Chamblee, GA 30341 USA. [Corum, Susan] Karuk Tribe Calif, Dept Nat Resources, Orleans, CA 95556 USA. RP Backer, LC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-57, Chamblee, GA 30341 USA. EM lbacker@cdc.gov RI Hill, Vincent/G-1789-2012; Osborne, Nicholas/N-4915-2015 OI Hill, Vincent/0000-0001-7069-7737; Osborne, Nicholas/0000-0002-6700-2284 NR 39 TC 50 Z9 54 U1 5 U2 39 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 2010 VL 55 IS 5 SI SI BP 909 EP 921 DI 10.1016/j.toxicon.2009.07.006 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 580GQ UT WOS:000276436400002 PM 19615396 ER PT J AU Premaratna, R Rajapakse, RPVJ Chandrasena, TGAN Nanayakkara, DM Bandara, NKBKRGW Kularatna, SAM Eremeeva, ME Dasch, GA de Silva, HJ AF Premaratna, R. Rajapakse, R. P. V. J. Chandrasena, T. G. A. N. Nanayakkara, D. M. Bandara, N. K. B. K. R. G. W. Kularatna, S. A. M. Eremeeva, M. E. Dasch, G. A. de Silva, H. J. TI Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Rickettsia infections; Orientia tsutsugamushi; Rickettsia conorii; Doxycycline; Fever; Sri Lanka AB Twenty-eight febrile Sri Lankan patients with undiagnosed fever for 7 days after hospital admission, who responded to empirical treatment with doxycycline, were retrospectively investigated using microimmunofluorescence assay to verify whether they had rickettsial infection. Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10(36%) as having Orientia tsutsugamushi. Seven were negative for all tests. This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. C1 [Premaratna, R.; de Silva, H. J.] Univ Kelaniya, Dept Med, Fac Med, Ragama, Sri Lanka. [Rajapakse, R. P. V. J.; Nanayakkara, D. M.] Univ Peradeniya, Fac Vet Med, Peradeniya, Sri Lanka. [Chandrasena, T. G. A. N.] Univ Kelaniya, Dept Parasitol, Fac Med, Ragama, Sri Lanka. [Bandara, N. K. B. K. R. G. W.] Univ Kelaniya, Dept Microbiol, Fac Med, Ragama, Sri Lanka. [Kularatna, S. A. M.] Univ Peradeniya, Dept Med, Peradeniya, Sri Lanka. [Eremeeva, M. E.; Dasch, G. A.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA USA. RP Premaratna, R (reprint author), Univ Kelaniya, Dept Med, Fac Med, POB 6,Thalagolla Rd, Ragama, Sri Lanka. EM ranjan_premaratna@lycos.com NR 3 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY PY 2010 VL 104 IS 5 BP 368 EP 370 DI 10.1016/j.trstmh.2009.10.006 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 599AD UT WOS:000277881200010 PM 19931108 ER PT J AU Ekwueme, DU Subramanian, S Trogdon, J Gardner, JG AF Ekwueme, D. U. Subramanian, S. Trogdon, J. Gardner, J. G. TI COST OF BREAST AND CERVICAL CANCER TREATMENT AND FOLLOW-UP CARE IN MEDICAID BENEFICARIES: IMPLICATIONS FOR STATE PROGRAMS PROVIDING COVERAGE FOR LOW-INCOME WOMEN SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Ekwueme, D. U.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Subramanian, S.] RTI Int, Waltham, MA USA. [Trogdon, J.] RTI Int, Res Triangle Pk, NC USA. [Gardner, J. G.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A49 EP A49 DI 10.1016/S1098-3015(10)72220-8 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121900237 ER PT J AU Lairson, DR Chang, YC Byrd, TL Smith, JL Wilson, KM AF Lairson, D. R. Chang, Y. C. Byrd, T. L. Smith, J. L. Wilson, K. M. TI COST-EFFECTIVENESS OF PROMOTORA LED HEALTH EDUCATION INTERVENTIONS TO INCREASE CERVICAL CANCER SCREENING AMONG LOW INCOME HISPANIC WOMEN SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Lairson, D. R.; Chang, Y. C.] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA. [Byrd, T. L.] Univ Texas El Paso, Sch Publ Hlth, El Paso, TX 79968 USA. [Smith, J. L.; Wilson, K. M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A37 EP A37 DI 10.1016/S1098-3015(10)72163-X PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121900180 ER PT J AU Li, C Ekwueme, DU Rim, SH Tangka, FK AF Li, C. Ekwueme, D. U. Rim, S. H. Tangka, F. K. TI MORTALITY COSTS FROM GENITAL CANCERS IN MEN-UNITED STATES, 2004 SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Li, C.; Ekwueme, D. U.; Rim, S. H.; Tangka, F. K.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A30 EP A30 DI 10.1016/S1098-3015(10)72128-8 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121900145 ER PT J AU Nurmagambetov, T Saha, S AF Nurmagambetov, T. Saha, S. TI RISK OF SERIOUS ASTHMA EXACERBATION AND SPIROMETRY TEST IN CHILDREN SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Nurmagambetov, T.; Saha, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A197 EP A197 DI 10.1016/S1098-3015(10)72964-8 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121901209 ER PT J AU Prosser, LA Lavelle, TA Fiore, A Bridges, CB Reed, C Jain, S Dunham, K Meltzer, M AF Prosser, L. A. Lavelle, T. A. Fiore, A. Bridges, C. B. Reed, C. Jain, S. Dunham, K. Meltzer, M. TI COST-EFFECTIVENESS OF 2009 PANDEMIC INFLUENZA A(H1N1) VACCINATION IN THE UNITED STATES SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Prosser, L. A.; Dunham, K.] Univ Michigan, Ann Arbor, MI 48109 USA. [Lavelle, T. A.] Harvard Univ, Boston, MA 02115 USA. [Fiore, A.; Bridges, C. B.; Reed, C.; Jain, S.; Meltzer, M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A192 EP A192 DI 10.1016/S1098-3015(10)72939-9 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121901184 ER PT J AU Ramsey, S Zeliadt, SB Blough, DK Fedorenko, CR Moinpour, CM Hall, IJH Smith, JL Ekwueme, DU Fairweather, ME Thompson, IM Keane, TE Penson, D AF Ramsey, S. Zeliadt, S. B. Blough, D. K. Fedorenko, C. R. Moinpour, C. M. Hall, I. J. H. Smith, Lee J. Ekwueme, D. U. Fairweather, M. E. Thompson, Jr I. M. Keane, T. E. Penson, D. TI A COMPARISON OF PHYSICIAN AND PATIENT DECISION MAKING FOR FIRST VERSUS SECOND OPINIONS AMONG MEN WITH LOCAL STAGE PROSTATE CANCER SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Ramsey, S.; Fedorenko, C. R.; Moinpour, C. M.; Fairweather, M. E.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Zeliadt, S. B.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Hall, I. J. H.; Smith, Lee J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ekwueme, D. U.] Ctr Dis Control & Prevent, Snellville, GA USA. [Thompson, Jr I. M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Keane, T. E.] Med Univ S Carolina, Med Ctr, Charleston, SC 29425 USA. [Penson, D.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A51 EP A51 DI 10.1016/S1098-3015(10)72233-6 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121900250 ER PT J AU Xu, X Macaluso, M Ouyang, L Grosse, S AF Xu, X. Macaluso, M. Ouyang, L. Grosse, S. TI TRENDS IN IUD INSERTIONS AND RELATED MEDICAL EXPENDITURE IN THE UNITED STATES: THE POPULATION WITH EMPLOYER-SPONSORED INSURANCE SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Xu, X.; Macaluso, M.; Ouyang, L.; Grosse, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD MAY PY 2010 VL 13 IS 3 BP A182 EP A182 DI 10.1016/S1098-3015(10)72886-2 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 589CJ UT WOS:000277121901131 ER PT J AU Brown, CR Strickler, SA Moore, AT Knutie, SA Padhi, A Brown, MB Young, GR O'Brien, VA Foster, JE Komar, N AF Brown, Charles R. Strickler, Stephanie A. Moore, Amy T. Knutie, Sarah A. Padhi, Abinash Brown, Mary Bomberger Young, Ginger R. O'Brien, Valerie A. Foster, Jerome E. Komar, Nicholas TI Winter Ecology of Buggy Creek Virus (Togaviridae, Alphavirus) in the Central Great Plains SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Arbovirus; Buggy Creek virus; Oeciacus vicarius; Overwintering; Petrochelidon pyrrhonota; Virus ecology ID CULEX-TARSALIS DIPTERA; WEST-NILE-VIRUS; EQUINE ENCEPHALITIS-VIRUS; TIME RT-PCR; VICARIUS HEMIPTERA CIMICIDAE; FORT-MORGAN VIRUS; OECIACUS-VICARIUS; CLIFF SWALLOWS; ENCEPHALOMYELITIS VIRUS; PIPIENS DIPTERA AB A largely unanswered question in the study of arboviruses is the extent to which virus can overwinter in adult vectors during the cold winter months and resume the transmission cycle in summer. Buggy Creek virus (BCRV; Togaviridae, Alphavirus) is an unusual arbovirus that is vectored primarily by the swallow bug (Hemiptera: Cimicidae: Oeciacus vicarius) and amplified by the ectoparasitic bug's main avian hosts, the migratory cliff swallow (Petrochelidon pyrrhonota) and resident house sparrow (Passer domesticus). Bugs are sedentary and overwinter in the swallows' mud nests. We evaluated the prevalence of BCRV and extent of infection in swallow bugs collected at different times in winter (October-early April) in Nebraska and explored other ecological aspects of this virus's overwintering. BCRV was detected in 17% of bug pools sampled in winter. Virus prevalence in bugs in winter at a site was significantly correlated with virus prevalence at that site the previous summer, but winter prevalence did not predict BCRV prevalence there the following summer. Prevalence was higher in bugs taken from house sparrow nests in winter and (in April) at colony sites where sparrows had been present all winter. Virus detected by reverse transcription (RT)-polymerase chain reaction in winter was less cytopathic than in summer, but viral RNA concentrations of samples in winter were not significantly different from those in summer. Both of the BCRV lineages (A, B) overwintered successfully, with lineage A more common at sites with house sparrows and (in contrast to summer) generally more prevalent in winter than lineage B. BCRV's ability to overwinter in its adult vector probably reflects its adaptation to the sedentary, long-lived bug and the ecology of the cliff swallow and swallow bug host-parasite system. Its overwintering mechanisms may provide insight into those of other alphaviruses of public health significance for which such mechanisms are poorly known. C1 [Brown, Charles R.; Strickler, Stephanie A.; Moore, Amy T.; Knutie, Sarah A.; Padhi, Abinash; Brown, Mary Bomberger; O'Brien, Valerie A.; Foster, Jerome E.] Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA. [Young, Ginger R.; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. RP Brown, CR (reprint author), Univ Tulsa, Dept Biol Sci, 800 S Tucker Dr, Tulsa, OK 74104 USA. EM charles-brown@utulsa.edu FU National Institutes of Health [AI057569]; National Science Foundation [DEB-0075199, DEB-0514824] FX Portions of this work represented an M. S. thesis by S. A. S. at the University of Tulsa. For laboratory and technical assistance, we thank Eric Edwards, Kenton Miller, Martin Pfeffer, and Karen Winans. The School of Biological Sciences at the University of Nebraska-Lincoln allowed us to use the Cedar Point Biological Station, and the Union Pacific Railroad and the Robert Clary, Dave Knight, and Loren Soper families granted us permission to access land. This work was supported by the National Institutes of Health (AI057569) and the National Science Foundation (DEB-0075199 and DEB-0514824). NR 64 TC 11 Z9 11 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAY PY 2010 VL 10 IS 4 BP 355 EP 363 DI 10.1089/vbz.2009.0031 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 592EI UT WOS:000277358700005 PM 19725760 ER PT J AU Kilpatrick, AM Dupuis, AP Chang, GJJ Kramer, LD AF Kilpatrick, A. Marm Dupuis, Alan P., II Chang, Gwong-Jen J. Kramer, Laura D. TI DNA Vaccination of American Robins (Turdus migratorius) Against West Nile Virus SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Culex pipiens; Disease control; Experimental infection; Herd immunity; Infectiousness Vaccine; Vector borne ID HOST FEEDING PATTERNS; UNITED-STATES; CULEX MOSQUITOS; BRIDGE VECTOR; INFECTION; TRANSMISSION; RABIES; BIRDS; FLAVIVIRUSES; PROTECTION AB West Nile virus (WNV) has caused at least 1150 cases of encephalitis, 100 deaths, and an estimated 30,000-80,000 illnesses in 6 of the last 7 years. Recent evidence from several regions has implicated American robins (Turdus migratorius) as an important host for feeding by Culex mosquitoes, and, when integrated with their host competence for WNV, demonstrates that they are a key WNV amplification host. We evaluated the efficacy of a DNA plasmid vaccine at reducing the viremia and infectiousness of hatch-year American robins. We found that a single dose of vaccine injected intramuscularly resulted in more than a 400-fold (10(2.6)) decrease in average viremia. Although sample sizes were small, these results suggest that vaccinated robins exhibit viremias that are likely to be mostly noninfectious to biting Culex mosquitoes. More broadly, if an orally effective formulation of this vaccine could be developed, new control strategies based on wildlife vaccination may be possible. C1 [Kilpatrick, A. Marm] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA. [Kilpatrick, A. Marm] Consortium Conservat Med, New York, NY USA. [Dupuis, Alan P., II; Kramer, Laura D.] New York State Dept Hlth, Slingerlands, NY USA. [Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Publ Hlth Serv, Div Vector Borne Infect Dis, US Dept HHS,Natl Ctr Zoonot Vector Borne & Enter, Ft Collins, CO USA. [Kramer, Laura D.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA. RP Kilpatrick, AM (reprint author), Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA. EM marm@biology.ucsc.edu FU NIAID [NO1-AI-25490]; Centers for Disease Control and Prevention [1RO1AI069217-01]; NSF [EF-0622391] FX We thank the field crew who helped catch the robins for this study (R. Peters, W. Janousek, B. Evans, and J. Dawson). This study was funded by NIAID contract #NO1-AI-25490, Centers for Disease Control and Prevention Grant 1RO1AI069217-01, and NSF Grant EF-0622391 as part of the joint NSF-NIH Ecology of Infectious Disease program. NR 34 TC 25 Z9 26 U1 2 U2 11 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAY PY 2010 VL 10 IS 4 BP 377 EP 380 DI 10.1089/vbz.2009.0029 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 592EI UT WOS:000277358700007 PM 19874192 ER PT J AU Brackney, MM Marfin, AA Staples, JE Stallones, L Keefe, T Black, WC Campbell, GL AF Brackney, Monica M. Marfin, Anthony A. Staples, J. Erin Stallones, Lorann Keefe, Thomas Black, William C. Campbell, Grant L. TI Epidemiology of Colorado Tick Fever in Montana, Utah, and Wyoming, 1995-2003 SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Colorado tick fever; Coltivirus; Dermacentor andersoni; Epidemiology; Tick-borne illness ID VIRUS; ENCEPHALITIS; DIAGNOSIS AB Colorado tick fever (CTF) is a biphasic, febrile illness caused by a Coltivirus and transmitted by the Rocky Mountain wood tick, Dermacentor andersoni, in the western United States and Canada. Symptoms generally include acute onset of fever, headache, chills, and myalgias; illness often lasts for 3 weeks or more. Laboratory-confirmed cases of CTF were identified from public health department records in Montana, Utah, and Wyoming, and from the Centers for Disease Control and Prevention diagnostic laboratory records. Additional descriptive epidemiologic data were obtained by medical record abstraction. Ninety-one cases were identified from 1995 to 2003, resulting in an overall annual incidence of 2.7 per 1,000,000 population. The annual incidence decreased over the 9-year study period. Cases were 2.5 times more frequent in males than females. The highest incidence of cases occurred in persons aged 51-70. Tick exposure prior to illness onset was reported in 90% of the cases in which a more detailed history was available. The most common symptoms were fever, headache, and myalgia; 18% of the case patients were hospitalized. While there has been an overall decline in the recognized incidence of CTF cases, the reasons for the decline are unknown. Possibilities include a reduced intensity of surveillance and a true decrease in incidence. As more people continue to visit, move to and work in endemic areas, CTF should be considered in anyone presenting with a febrile illness following tick exposure in an endemic area. Heightened awareness for the disease and tick prevention messages should be part of public health measures to further decrease the incidence of disease. C1 [Brackney, Monica M.; Stallones, Lorann; Keefe, Thomas; Black, William C.] Colorado State Univ, Ft Collins, CO 80523 USA. [Marfin, Anthony A.; Staples, J. Erin; Campbell, Grant L.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, US Dept HHS, US Publ Hlth Serv, Ft Collins, CO USA. RP Brackney, MM (reprint author), New Mexico Dept Hlth, 1190 St Francis Dr, Santa Fe, NM 87502 USA. EM monica.brackney@state.nm.us NR 11 TC 6 Z9 6 U1 2 U2 15 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAY PY 2010 VL 10 IS 4 BP 381 EP 385 DI 10.1089/vbz.2009.0065 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 592EI UT WOS:000277358700008 PM 19725767 ER PT J AU Castleman, WL Powe, JR Crawford, PC Gibbs, EPJ Dubovi, EJ Donis, RO Hanshaw, D AF Castleman, W. L. Powe, J. R. Crawford, P. C. Gibbs, E. P. J. Dubovi, E. J. Donis, R. O. Hanshaw, D. TI Canine H3N8 Influenza Virus Infection in Dogs and Mice SO VETERINARY PATHOLOGY LA English DT Article DE canine influenza virus; equine influenza virus; canine respiratory disease; mouse influenza model ID A VIRUSES; H5N1; TRANSMISSION; MACROPHAGES; EMERGENCE; VIRULENCE; DISEASE; CELLS; MODEL; EGGS AB An H3N8 influenza virus closely related to equine influenza virus was identified in racing greyhound dogs with respiratory disease in 2004 and subsequently identified in shelter and pet dogs. Pathologic findings in dogs spontaneously infected with canine influenza virus were compared with lesions induced in beagle and mongrel dogs following experimental inoculation with influenza A/canine/Florida/43/2004. BALB/c mice were inoculated with canine influenza virus to assess their suitability as an experimental model for viral pathogenesis studies. All dogs inoculated with virus developed necrotizing and hyperplastic tracheitis and bronchitis with involvement of submucosal glands as well as mild bronchiolitis and pneumonia. Viral antigen was identified in bronchial and tracheal epithelial cells of all dogs and in alveolar macrophages of several dogs. Many dogs that were spontaneously infected with virus also developed bacterial pneumonia, and greyhound dogs with fatal spontaneous infection developed severe pulmonary hemorrhage with hemothorax. Virus-inoculated BALB/c mice developed tracheitis, bronchitis, bronchiolitis, and mild pneumonia in association with viral antigen in airway epithelial cells and in type 2 alveolar epithelial cells. Virus was not detected in extrarespiratory sites in any animals. The results indicate that canine influenza virus infection consistently induces acute tracheitis and bronchitis in dogs. Mice may be a useful model for some pathogenesis studies on canine influenza virus infection. C1 [Castleman, W. L.] Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL 32611 USA. [Dubovi, E. J.] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA. [Donis, R. O.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA. RP Castleman, WL (reprint author), Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL 32611 USA. EM castlemanw@vetmed.ufl.edu FU State of Florida Pari-Mutuel Wagering Trust; College of Veterinary Medicine FX The authors declared the following financial support for the research and/or authorship of this article: Supported in part by a State of Florida Pari-Mutuel Wagering Trust Fund research grant and by College of Veterinary Medicine Consolidated Research Funds. NR 33 TC 16 Z9 17 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD MAY PY 2010 VL 47 IS 3 BP 507 EP 517 DI 10.1177/0300985810363718 PG 11 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 593SH UT WOS:000277480400012 PM 20351357 ER PT J AU Kuzmin, IV Mayer, AE Niezgoda, M Markotter, W Agvvanda, B Breiman, RF Rupprecht, CE AF Kuzmin, Ivan V. Mayer, Anne E. Niezgoda, Michael Markotter, Wanda Agvvanda, Bernard Breiman, Robert F. Rupprecht, Charles E. TI Shimoni bat virus, a new representative of the Lyssavirus genus SO VIRUS RESEARCH LA English DT Article DE Rabies; Lyssavirus; Rhabdovirus; Shimoni bat virus; Phylogeny; Chiroptera; Zoonosis; Africa; Kenya ID FATAL HUMAN INFECTION; RABIES VIRUS; MOKOLA-VIRUS; LAGOS-BAT; PHYLOGENETIC-RELATIONSHIPS; GENOME SEQUENCE; SOUTH-AFRICA; GLYCOPROTEIN; PATHOGENICITY; EPIDEMIOLOGY AB During 2009, 616 bats representing at least 22 species were collected from 10 locations throughout Kenya. A new lyssavirus, named Shimoni bat virus (SHIBV), was isolated from the brain of a dead Commerson's leaf-nosed bat (Hipposideros commersoni), found in a cave in the coastal region of Kenya. Genetic distances and phylogenetic reconstructions, implemented for each gene and for the concatenated alignment of all five structural genes (N, P, M, G and L), demonstrated that SHIBV cannot be identified with any of the existing species, but rather should be considered an independent species within phylogroup II of the Lyssavirus genus, most similar to Lagos bat virus (LBV). Antigenic reaction patterns with anti-nucleocapsid monoclonal antibodies corroborated these distinctions. In addition, new data on the diversity of LBV suggests that this species may be subdivided quantitatively into three separate genotypes. However, the identity values alone are not considered sufficient criteria for demarcation of new species within LBV. Published by Elsevier B.V. C1 [Kuzmin, Ivan V.; Niezgoda, Michael; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Rabies Program, Poxvirus & Rabies Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. [Mayer, Anne E.] Univ Minnesota, St Paul, MN 55102 USA. [Markotter, Wanda] Univ Pretoria, Fac Nat & Agr Sci, Dept Microbiol & Plant Pathol, ZA-0001 Pretoria, South Africa. [Agvvanda, Bernard] Natl Museums Kenya, Mammal Sect, Nairobi 00100, Kenya. [Breiman, Robert F.] Ctr Dis Control & Prevent Kenya, Global Dis Detect Div, Nairobi 00100, Kenya. RP Kuzmin, IV (reprint author), Ctr Dis Control & Prevent, Rabies Program, Poxvirus & Rabies Branch, Div Viral & Rickettsial Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM ivkuzmin@yandex.ru OI Markotter, Wanda/0000-0002-7550-0080 FU Centers for Disease Control and Prevention (Atlanta, GA) FX The study was supported in part by the Global Disease Detection program of the Centers for Disease Control and Prevention (Atlanta, GA). We thank Edwin Danga, Evelyne Mulama, Solomon Gikundi and Leonard Nderitu (CDC-Kenya, Nairobi) for excellent logistic and laboratory support, and Mang Shi (University of Hong Kong, Hong Kong) for productive discussions on phylogenetic analysis. NR 62 TC 77 Z9 85 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD MAY PY 2010 VL 149 IS 2 BP 197 EP 210 DI 10.1016/j.virusres.2010.01.018 PG 14 WC Virology SC Virology GA 587BU UT WOS:000276962700009 PM 20138934 ER PT J AU Petersen, LR Busch, MP AF Petersen, L. R. Busch, M. P. TI Transfusion-transmitted arboviruses SO VOX SANGUINIS LA English DT Review DE arbovirus; transfusion; transmission ID WEST-NILE-VIRUS; RIFT-VALLEY FEVER; TICK-BORNE ENCEPHALITIS; ONYONG-NYONG FEVER; BLOOD-TRANSFUSION; CHIKUNGUNYA-VIRUS; ESTIMATED RISK; UNITED-STATES; INDIAN-OCEAN; JAPANESE ENCEPHALITIS AB There exists considerable risk for transfusion transmission of arboviruses due to short periods of asymptomatic viraemia in populations with variable and sometimes extremely high incidence of arboviral infections. Aside from West Nile virus, few arbovirus transfusion transmissions have been proven, mostly due to difficulties in ruling out vector-borne transmission in recipients with arbovirus disease. Nevertheless, arbovirus transfusion risk models and assessments of viraemia prevalence in blood donations indicate substantial transfusion transmission of dengue and Chikungunya viruses in epidemic areas. Many other arboviruses, several of which are importation risks in the Americas, Europe and Asia, also cause large outbreaks and threaten transfusion safety. Prevention largely depends on excluding donors from outbreak areas or implementation of highly sensitive nucleic acid amplification tests. Because of the increasing emergence of arboviral disease globally, it is prudent to prepare for both endemic and exotic arboviruses capable of producing large epidemics and subsequent transfusion transmission risk. C1 [Petersen, L. R.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Busch, M. P.] Blood Syst Res Inst, San Francisco, CA USA. [Busch, M. P.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Petersen, LR (reprint author), CDC, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM lxp2@cdc.gov NR 61 TC 49 Z9 54 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD MAY PY 2010 VL 98 IS 4 BP 495 EP 503 DI 10.1111/j.1423-0410.2009.01286.x PG 9 WC Hematology SC Hematology GA 584ZY UT WOS:000276795100002 PM 19951309 ER PT J AU Anderson, BA Maslia, ML Caparoso, JL Ausdemore, D Aral, MM AF Anderson, B. A. Maslia, M. L. Caparoso, J. L. Ausdemore, D. Aral, M. M. TI Stochastic Analysis of Pesticide Transport in the Shallow Groundwater of Oatland Island, Georgia, USA SO WATER QUALITY EXPOSURE AND HEALTH LA English DT Article DE Analytical solutions; Monte Carlo simulation; Pesticide transport; Probabilistic analysis; Screening-level model; United States; Wetlands AB Analytical models, when used in stochastic analysis mode, may provide an effective tool for making informed management decisions for simplified environmental systems. This approach was used to evaluate migration of an organochlorine pesticide plume in a shallow, unconfined aquifer underlying a barrier island in coastal Georgia, USA. The contaminant plume at the site consists of four isomers of benzene hexachloride (BHC), also known as hexachlorocyclohexane (HCH). The deterministic analysis conducted at the site, which used calibrated, single-value input parameters, indicates that the contaminant plume will not reach wetlands that are downgradient of the source. Given the uncertainties involved in the deterministic analysis, this outcome was not considered to be sufficient to make effective management decisions at the site. Subsequently, probabilistic analysis using a range of input parameter values was conducted to estimate the risk that the pesticide plume would reach the downgradient wetlands. The two-stage Monte Carlo analysis that was conducted indicates the probability that contaminant levels will exceed the detection limit of BHC (0.044 micrograms per liter) at the wetlands increases from 1 percent to a maximum of 13 percent during the period 2005-2065. This represents an 87% or greater confidence level that the pesticide plume will not reach the wetlands. This outcome was used to inform environmental management decisions at the site. The modeling analysis was conducted using the publicly available analytical contaminant transport analysis system (ACTS) software. C1 [Anderson, B. A.; Maslia, M. L.] Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA. [Caparoso, J. L.] US Army Ctr Hlth Promot & Prevent Med Europe, Landstuhl, Germany. [Ausdemore, D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Aral, M. M.] Georgia Inst Technol, Sch Civil & Environm Engn, Multimedia Environm Simulat Lab, Atlanta, GA 30332 USA. RP Anderson, BA (reprint author), Agcy Tox Subst & Dis Registry, 4770 Buford Highway NE,Mail Stop F-59, Atlanta, GA 30341 USA. EM baanderson@cdc.gov FU Agency for Toxic Substances and Disease Registry; Centers for Disease Control and Prevention FX This project was funded by the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control and Prevention. The authors acknowledge their colleagues at ATSDR, including Rene Suarez-Soto, John Mann, and Susan Moore, for providing assistance and advice on this project. Caryl Wipperfurth from the U.S. Geological Survey, Atlanta, Georgia assisted with the preparation of illustrations. NR 39 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1876-1658 EI 1876-1666 J9 WATER QUAL EXPOS HEA JI Water Qual. Expos. Health PD MAY PY 2010 VL 2 IS 1 BP 47 EP 64 DI 10.1007/s12403-010-0023-6 PG 18 WC Water Resources SC Water Resources GA V35HF UT WOS:000209140300003 ER PT J AU Kamb, ML AF Kamb, Mary L. TI Congenital syphilis: not gone and all too forgotten SO WORLD JOURNAL OF PEDIATRICS LA English DT Editorial Material C1 US Ctr Dis Control & Prevent CDC, Div STD Prevent, Atlanta, GA USA. RP Kamb, ML (reprint author), US Ctr Dis Control & Prevent CDC, Div STD Prevent, Atlanta, GA USA. EM mlk5@cdc.gov NR 10 TC 4 Z9 6 U1 0 U2 0 PU ZHEJIANG UNIV SCH MEDICINE PI HANGZHOU PA CHILDRENS HOSPITAL, 57 ZHUGAN XIANG, HANGZHOU, 310003, PEOPLES R CHINA SN 1708-8569 J9 WORLD J PEDIATR JI World Journal of Pediatrics PD MAY PY 2010 VL 6 IS 2 BP 101 EP 102 DI 10.1007/s12519-010-0024-3 PG 2 WC Pediatrics SC Pediatrics GA 597QU UT WOS:000277775800001 PM 20490764 ER PT J AU Ouma, PO van Eijk, AM Hamel, MJ Sikuku, ES Odhiambo, FO Munguti, KM Ayisi, JG Crawford, SB Kager, PA Slutsker, L AF Ouma, Peter O. van Eijk, Anna M. Hamel, Mary J. Sikuku, Evallyne S. Odhiambo, Frank O. Munguti, Kaendi M. Ayisi, John G. Crawford, Sara B. Kager, Piet A. Slutsker, Laurence TI Antenatal and delivery care in rural western Kenya: the effect of training health care workers to provide "focused antenatal care" SO REPRODUCTIVE HEALTH LA English DT Article AB Background: Maternal mortality remains high in developing countries and data to monitor indicators of progress in maternal care is needed. We examined the status of maternal care before and after health care worker (HCW) training in WHO recommended Focused Antenatal Care. Methods: An initial cross-sectional survey was conducted in 2002 in Asembo and Gem in western Kenya among a representative sample of women with a recent birth. HCW training was performed in 2003 in Asembo, and a repeat survey was conducted in 2005 in both areas. Results: Antenatal clinic (ANC) attendance was similar in both areas (86%) in 2005 and not significantly different from 2002 (90%). There was no difference in place of delivery between the areas or over time. However, in 2005, more women in Asembo were delivered by a skilled assistant compared to Gem (30% vs. 23%, P = 0.04), and this proportion increased compared to 2002 (17.6% and 16.1%, respectively). Provision of iron (82.4%), folic acid (72.0%), sulfadoxine-pyrimethamine (61.7%), and anthelminths (12.7%) had increased in Asembo compared to 2002 (2002: 53.3%, 52.8%, 20.3%, and 4.6%, respectively), and was significantly higher than in Gem in 2005 (Gem 2005: 69.7%, 47.8%, 19.8%, and 4.1%, respectively) (P < 0.05 for all). Offering of tests for sexually transmitted diseases and providing information related to maternal health was overall low (< 20%) and did not differ by area. In 2005, more women rated the quality of the antenatal service in Asembo as very satisfactory compared to Gem (17% vs. 6.5%, P < 0.05). Conclusions: We observed improvements in some ANC services in the area where HCWs were trained. However, since our evaluation was carried out 2 years after three-day training, we consider any significant, sustained improvement to be remarkable. C1 [Ouma, Peter O.; Hamel, Mary J.; Sikuku, Evallyne S.; Odhiambo, Frank O.; Ayisi, John G.] Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu, Kenya. [van Eijk, Anna M.; Kager, Piet A.] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1012 WX Amsterdam, Netherlands. [Ouma, Peter O.; Hamel, Mary J.; Sikuku, Evallyne S.; Odhiambo, Frank O.; Crawford, Sara B.; Slutsker, Laurence] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. [Munguti, Kaendi M.] Univ Nairobi, Nairobi, Kenya. RP Ouma, PO (reprint author), Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu, Kenya. EM pouma@ke.cdc.gov NR 44 TC 18 Z9 18 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4755 J9 REPROD HEALTH JI Reprod. Health PD APR 29 PY 2010 VL 7 AR 1 DI 10.1186/1742-4755-7-1 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V27IC UT WOS:000208605900001 PM 20429906 ER PT J AU Johnson, M Urquidi, A Lozano, R Norton, J Andrews, C Lorentine, A Fallon, A Ziegler, P Hobbs, D Brown, G Kenney, K Tulloch, S de Ravello, L Peterman, T Taylor, M AF Johnson, M. Urquidi, A. Lozano, R. Norton, J. Andrews, C. Lorentine, A. Fallon, A. Ziegler, P. Hobbs, D. Brown, G. Kenney, K. Tulloch, S. de Ravello, L. Peterman, T. Taylor, M. TI Syphilis Outbreak Among American Indians-Arizona, 2007-2009 (Reprinted from MMWR, vol 59, pg 158-161, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Johnson, M.; Urquidi, A.; Lozano, R.; Norton, J.] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Kenney, K.; Tulloch, S.; de Ravello, L.; Peterman, T.; Taylor, M.] CDC, Atlanta, GA 30333 USA. RP Johnson, M (reprint author), Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 28 PY 2010 VL 303 IS 16 BP 1588 EP 1589 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 588PQ UT WOS:000277085200009 ER PT J AU Villarruel, GR Langley, GE Abedi, GR Anderson, LJ AF Villarruel, G. R. Langley, G. E. Abedi, G. R. Anderson, L. J. CA Natl Resp & Enteric Virus Surveill TI Respiratory Syncytial Virus Activity-United States, July 2008-December 2009 (Reprinted from MMWR, vol 59, pg 230-233, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Villarruel, G. R.; Langley, G. E.; Abedi, G. R.; Anderson, L. J.; Natl Resp & Enteric Virus Surveill] CDC, Atlanta, GA 30333 USA. RP Villarruel, GR (reprint author), CDC, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 28 PY 2010 VL 303 IS 16 BP 1590 EP 1591 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 588PQ UT WOS:000277085200010 ER PT J AU Mazurek, JM Laney, AS Wood, JM AF Mazurek, J. M. Laney, A. S. Wood, J. M. TI Coal Workers' Pneumoconiosis-Related Years of Potential Life Lost Before Age 65 Years-United States, 1968-2006 (Reprinted from MMWR, vol 58, pg 1412-1416, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID MORTALITY C1 [Mazurek, J. M.; Laney, A. S.; Wood, J. M.] CDC, Div Resp Dis Studies, NIOSH, Atlanta, GA 30333 USA. RP Mazurek, JM (reprint author), CDC, Div Resp Dis Studies, NIOSH, Atlanta, GA 30333 USA. NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 28 PY 2010 VL 303 IS 16 BP 1591 EP 1593 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 588PQ UT WOS:000277085200011 ER PT J AU Carr, JK Wolfe, ND Torimiro, JN Tamoufe, U Mpoudi-Ngole, E Eyzaguirre, L Birx, DL McCutchan, FE Burke, DS AF Carr, Jean K. Wolfe, Nathan D. Torimiro, Judith N. Tamoufe, Ubald Mpoudi-Ngole, E. Eyzaguirre, Lindsay Birx, Deborah L. McCutchan, Francine E. Burke, Donald S. TI HIV-1 recombinants with multiple parental strains in low-prevalence, remote regions of Cameroon: Evolutionary relics? SO RETROVIROLOGY LA English DT Article ID VIRUS TYPE-1 HIV-1; DUAL INFECTIONS; CENTRAL-AFRICA; SUBTYPES; SEQUENCES; CHIMPANZEES; DIVERSITY; EPIDEMIC; CRF02-AG; ASSAY AB Background: The HIV pandemic disseminated globally from Central West Africa, beginning in the second half of the twentieth century. To elucidate the virologic origins of the pandemic, a cross-sectional study was conducted of the genetic diversity of HIV-1 strains in villagers in 14 remote locations in Cameroon and in hospitalized and STI patients. DNA extracted from PBMC was PCR amplified from HIV(+) subjects. Partial pol amplicons (N = 164) and nearly full virus genomes (N = 78) were sequenced. Among the 3956 rural villagers studied, the prevalence of HIV infection was 4.9%; among the hospitalized and clinic patients, it was 8.6%. Results: Virus genotypes fell into two distinctive groups. A majority of the genotyped strains (109/164) were the circulating recombinant form (CRF) known to be endemic in West Africa and Central West Africa, CRF02_AG. The second most common genetic form (9/164) was the recently described CRF22_01A1, and the rest were a collection of 4 different subtypes (A2, D, F2, G) and 6 different CRFs (-01, -11, -13, -18, -25, -37). Remarkably, 10.4% of HIV-1 genomes detected (17/164) were heretofore undescribed unique recombinant forms (URF) present in only a single person. Nearly full genome sequencing was completed for 78 of the viruses of interest. HIV genetic diversity was commonplace in rural villages: 12 villages each had at least one newly detected URF, and 9 villages had two or more. Conclusions: These results show that while CRF02_AG dominated the HIV strains in the rural villages, the remainder of the viruses had tremendous genetic diversity. Between the trans-species transmission of SIV(cpz) and the dispersal of pandemic HIV-1, there was a time when we hypothesize that nascent HIV-1 was spreading, but only to a limited extent, recombining with other local HIV-1, creating a large variety of recombinants. When one of those recombinants began to spread widely (i.e. became epidemic), it was recognized as a subtype. We hypothesize that the viruses in these remote Cameroon villages may represent that pre-epidemic stage of viral evolution. C1 [Carr, Jean K.; Eyzaguirre, Lindsay] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Wolfe, Nathan D.] Global Viral Forecasting Initiat, San Francisco, CA USA. [Wolfe, Nathan D.] Stanford Univ, Program Human Biol, Stanford, CA 94305 USA. [Torimiro, Judith N.] Univ Yaounde 1, Fac Med & Biomed Sci, Yaounde, Cameroon. [Torimiro, Judith N.] Chantal Biya Int Reference Ctr, Yaounde, Cameroon. [Tamoufe, Ubald; Mpoudi-Ngole, E.] Hop Mil Yaounde, Yaounde, Cameroon. [Birx, Deborah L.] CDC, Global AIDS Program, Atlanta, GA 30333 USA. [McCutchan, Francine E.] Bill & Melinda Gates Fdn, Seattle, WA USA. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. RP Carr, JK (reprint author), Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. EM jecarr@ihv.umaryland.edu OI /0000-0002-5704-8094 FU National Institutes of Health Director's Pioneer Award [DP1-OD000370]; WW Smith Charitable Trust; US Military HIV Research Program; NIH Fogarty International Center [5 K01 TW000003-05]; AIDS International Training and Research Program [2 D 43 TW000010-17-AITRP]; National Geographic Society Committee for Research and Exploration [7762-04]; Global Viral Forecasting Initiative, Google.org; Skoll Foundation; Cameroon Ministry of Defense, Ministry of Health; Ministry of Scientific Research and Innovation FX NDW was supported by awards from the National Institutes of Health Director's Pioneer Award (Grant DP1-OD000370), the WW Smith Charitable Trust, the US Military HIV Research Program, and grants from the NIH Fogarty International Center (International Research Scientist Development Award Grant 5 K01 TW000003-05), AIDS International Training and Research Program (Grant 2 D 43 TW000010-17-AITRP), and the National Geographic Society Committee for Research and Exploration (Grant #7762-04). This research was supported in part by the Global Viral Forecasting Initiative, Google.org, and The Skoll Foundation. Thanks to the entire staff of GVFI-Cameroon for their support and assistance. The Cameroon Ministry of Defense, Ministry of Health, and Ministry of Scientific Research and Innovation provided authorizations and support for this work. The authors express many thanks to the editorial assistance of Este Armstrong. NR 29 TC 25 Z9 26 U1 2 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD APR 28 PY 2010 VL 7 AR 39 DI 10.1186/1742-4690-7-39 PG 8 WC Virology SC Virology GA 605ET UT WOS:000278331100001 PM 20426823 ER PT J AU Tan, LKK Carlone, GM Borrow, R AF Tan, Lionel K. K. Carlone, George M. Borrow, Ray TI CURRENT CONCEPTS Advances in the Development of Vaccines against Neisseria meningitidis SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review ID FACTOR-H-BINDING; SEROGROUP-B MENINGOCOCCUS; CONJUGATE VACCINE; PROTEIN VACCINE; VESICLE VACCINE; HUMAN IMMUNITY; HERD-IMMUNITY; N-CAM; IMMUNOGENICITY; DISEASE C1 [Borrow, Ray] Manchester Royal Infirm, Hlth Protect Agcy, Manchester M13 9WZ, Lancs, England. [Tan, Lionel K. K.] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, London, England. [Carlone, George M.] Ctr Dis Control & Prevent, Immunol Labs, Atlanta, GA USA. RP Borrow, R (reprint author), Manchester Royal Infirm, Hlth Protect Agcy, Oxford Rd, Manchester M13 9WZ, Lancs, England. EM ray.borrow@hpa.org.uk FU Wellcome Trust FX Supported by a grant from the Wellcome Trust (to Dr. Tan). NR 58 TC 122 Z9 126 U1 1 U2 13 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 22 PY 2010 VL 362 IS 16 BP 1511 EP 1520 DI 10.1056/NEJMra0906357 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 586GP UT WOS:000276894700010 PM 20410516 ER PT J AU Brimmer, DJ Fridinger, F Lin, JMS Reeves, WC AF Brimmer, Dana J. Fridinger, Frederick Lin, Jin-Mann S. Reeves, William C. TI US healthcare providers' knowledge, attitudes, beliefs, and perceptions concerning Chronic Fatigue Syndrome SO BMC FAMILY PRACTICE LA English DT Article ID POPULATION; GEORGIA AB Background: Chronic fatigue syndrome (CFS) is a debilitating illness with particular difficulties for healthcare providers because there are no diagnostic signs or laboratory tests and because management aims to merely improve symptoms. Further complicating management, healthcare providers' awareness concerning CFS has not been rigorously assessed. The present study aimed to ascertain United States (U. S.) healthcare providers' awareness of CFS and to assess their knowledge, attitudes, and beliefs (KAB) related to diagnosis and management of the illness. This information forms the foundation for developing CFS educational strategies. Methods: We combined convenience and probability samples to measure CFS KAB among healthcare providers. In the convenience sample, 1,255 healthcare providers (81% response rate) from 13 professional conferences completed a 12-item form. Descriptive statistics were reported for 9 KAB item responses and chi-square tests were performed for examining their association with giving a diagnosis of CFS. We used principal component analysis to construct multidimensional subscales and perform a general linear model to examine factors associated with subscales. The probability sample involved data on 15 CFS-specific questions from 2006 and 2007 DocStyles web-based panel surveys collected from 2,750 physicians (average response rate 55%). We calculated descriptive and chi-square statistics. The significance was set at two-tailed with the alpha level of 0.05. Results: Healthcare providers in both samples were aware of CFS and exhibited a high level of knowledge. Overall, 96% of respondents in the DocStyles (probability) sample had heard about CFS. Healthcare providers in the conference (convenience) sample demonstrated good KAB scores; physicians' scores were highest on KAB scales and lowest in perception. Nurses' scores were lowest in knowledge. More than 40% of physicians reported ever giving a CFS diagnosis and in the DocStyles (probability) sample more than 80% of physicians correctly identified CFS symptoms. Physicians reported professional journals, the Internet, and continuing education programs as the top 3 sources from which they obtain CFS information. Conclusions: Findings from these combined samples fill a gap in the evidence-base of U. S. healthcare providers' and knowledge, attitudes, and beliefs concerning CFS. Importantly, respondents in both samples expressed similar knowledge, attitudes, beliefs and perceptions. Awareness was high and negative attitudes were low. The primary areas for future education should address diagnosis and management of CFS and should be delivered through those venues providers indicated they primarily use. Data from this study provide a benchmark for evaluation the success of these future efforts. C1 [Brimmer, Dana J.; Lin, Jin-Mann S.; Reeves, William C.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. [Fridinger, Frederick] Ctr Dis Control & Prevent, Div Hlth Commun & Mkt, Atlanta, GA USA. RP Brimmer, DJ (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. EM dyv4@cdc.gov NR 20 TC 12 Z9 12 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2296 J9 BMC FAM PRACT JI BMC Fam. Pract. PD APR 21 PY 2010 VL 11 AR 28 DI 10.1186/1471-2296-11-28 PG 15 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 605TW UT WOS:000278370900001 PM 20406491 ER PT J AU Harrington, T Manangan, L Jereb, J Navin, T Powell, K AF Harrington, T. Manangan, L. Jereb, J. Navin, T. Powell, K. TI Severe Isoniazid-Associated Liver Injuries Among Persons Being Treated for Latent Tuberculosis Infection-United States, 2004-2008 (Reprinted from JAMA, vol 59, pg 224-229, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Powell, K.] CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 21 PY 2010 VL 303 IS 15 BP 1471 EP 1473 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 585SJ UT WOS:000276849000009 ER PT J AU Burke, C Torres, M Warren, K Sandt, C Adams, J Webeck, J Ewald, G Behravesh, CB Patel, A Neil, K Han, G AF Burke, C. Torres, M. Warren, K. Sandt, C. Adams, J. Webeck, J. Ewald, G. Behravesh, C. Barton Patel, A. Neil, K. Han, G. TI Multistate Outbreak of Human Salmonella Typhimurium Infections Associated With Pet Turtle Exposure-United States, 2008 (Reprinted from JAMA, vol 59, pg 191-196, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Burke, C.; Torres, M.] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Warren, K.; Sandt, C.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Patel, A.; Neil, K.; Han, G.] CDC, EIS Officers, Atlanta, GA 30333 USA. RP Burke, C (reprint author), Philadelphia Dept Publ Hlth, Philadelphia, PA USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 21 PY 2010 VL 303 IS 15 BP 1473 EP 1476 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 585SJ UT WOS:000276849000010 ER PT J AU Welsh, JA Sharma, A Abramson, JL Vaccarino, V Gillespie, C Vos, MB AF Welsh, Jean A. Sharma, Andrea Abramson, Jerome L. Vaccarino, Viola Gillespie, Cathleen Vos, Miriam B. TI Caloric Sweetener Consumption and Dyslipidemia Among US Adults SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID SUGARS; BEVERAGES; HEALTH; FOODS; DIET; NUTRITION; NUTRIENTS; FRUCTOSE; CHILDREN; LIPIDS AB Context Dietary carbohydrates have been associated with dyslipidemia, a lipid profile known to increase cardiovascular disease risk. Added sugars (caloric sweeteners used as ingredients in processed or prepared foods) are an increasing and potentially modifiable component in the US diet. No known studies have examined the association between the consumption of added sugars and lipid measures. Objective To assess the association between consumption of added sugars and blood lipid levels in US adults. Design, Setting, and Participants Cross-sectional study among US adults (n=6113) from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. Respondents were grouped by intake of added sugars using limits specified in dietary recommendations (<5% [reference group], 5%-<10%, 10%-<17.5%, 17.5%-<25%, and >= 25% of total calories). Linear regression was used to estimate adjusted mean lipid levels. Logistic regression was used to determine adjusted odds ratios of dyslipidemia. Interactions between added sugars and sex were evaluated. Main Outcome Measures Adjusted mean high-density lipoprotein cholesterol (HDL-C), geometric mean triglycerides, and mean low-density lipoprotein cholesterol (LDL-C) levels and adjusted odds ratios of dyslipidemia, including low HDL-C levels (<40 mg/dL for men; <50 mg/dL for women), high triglyceride levels (>= 150 mg/dL), high LDL-C levels (>130 mg/dL), or high ratio of triglycerides to HDL-C (>3.8). Results were weighted to be representative of the US population. Results A mean of 15.8% of consumed calories was from added sugars. Among participants consuming less than 5%, 5% to less than 17.5%, 17.5% to less than 25%, and 25% or greater of total energy as added sugars, adjusted mean HDL-C levels were, respectively, 58.7, 57.5, 53.7, 51.0, and 47.7 mg/dL (P<.001 for linear trend), geometric mean triglyceride levels were 105, 102, 111, 113, and 114 mg/dL (P<.001 for linear trend), and LDL-C levels modified by sex were 116, 115, 118, 121, and 123 mg/dL among women (P=.047 for linear trend). There were no significant trends in LDL-C levels among men. Among higher consumers (>= 10% added sugars) the odds of low HDL-C levels were 50% to more than 300% greater compared with the reference group (<5% added sugars). Conclusion In this study, there was a statistically significant correlation between dietary added sugars and blood lipid levels among US adults. JAMA. 2010; 303(15): 1490-1497 C1 [Welsh, Jean A.; Sharma, Andrea; Vaccarino, Viola; Vos, Miriam B.] Emory Univ, Nutr & Hlth Sci Program, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA. [Abramson, Jerome L.; Vaccarino, Viola] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Vaccarino, Viola] Emory Univ, Div Cardiol, Sch Med, Atlanta, GA 30322 USA. [Vos, Miriam B.] Emory Univ, Dept Pediat Gastroenterol Hepatol & Nutr, Sch Med, Atlanta, GA 30322 USA. [Welsh, Jean A.; Vos, Miriam B.] Childrens Healthcare Atlanta, Atlanta, GA USA. [Sharma, Andrea] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Gillespie, Cathleen] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Vos, MB (reprint author), Emory Univ, Nutr & Hlth Sci Program, Grad Div Biol & Biomed Sci, 2015 Uppergate Dr NE, Atlanta, GA 30322 USA. EM mvos@emory.edu OI Sharma, Andrea/0000-0003-0385-0011 FU National Institute of Diabetes and Digestive and Kidney Diseases [K23DK080953]; Children's Digestive Health and Nutrition Foundation FX Dr Vos reported that she is the author of and receives royalties from a book about childhood obesity and that she is supported in part by a career award from the National Institute of Diabetes and Digestive and Kidney Diseases (K23DK080953) and from the Children's Digestive Health and Nutrition Foundation. No other authors reported disclosures. NR 37 TC 108 Z9 112 U1 3 U2 19 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 21 PY 2010 VL 303 IS 15 BP 1490 EP 1497 DI 10.1001/jama.2010.449 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 585SJ UT WOS:000276849000025 PM 20407058 ER PT J AU Siston, AM Rasmussen, SA Honein, MA Fry, AM Seib, K Callaghan, WM Louie, J Doyle, TJ Crockett, M Lynfield, R Moore, Z Wiedeman, C Anand, M Tabony, L Nielsen, CF Waller, K Page, S Thompson, JM Avery, C Springs, CB Jones, T Williams, JL Newsome, K Finelli, L Jamieson, DJ AF Siston, Alicia M. Rasmussen, Sonja A. Honein, Margaret A. Fry, Alicia M. Seib, Katherine Callaghan, William M. Louie, Janice Doyle, Timothy J. Crockett, Molly Lynfield, Ruth Moore, Zack Wiedeman, Caleb Anand, Madhu Tabony, Laura Nielsen, Carrie F. Waller, Kirsten Page, Shannon Thompson, Jeannie M. Avery, Catherine Springs, Chasisity Brown Jones, Timothy Williams, Jennifer L. Newsome, Kim Finelli, Lyn Jamieson, Denise J. CA Pandemic H1N1 Influenza Pregnancy TI Pandemic 2009 Influenza A(H1N1) Virus Illness Among Pregnant Women in the United States SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID A H1N1 VIRUS; RANDOMIZED CONTROLLED-TRIAL; CRITICALLY-ILL PATIENTS; OSELTAMIVIR TREATMENT; DIAGNOSTIC-TESTS; ASIAN INFLUENZA; INFECTION; VACCINATION; IMPACT; SAFETY AB Context Early data on pandemic 2009 influenza A(H1N1) suggest pregnant women are at increased risk of hospitalization and death. Objective To describe the severity of 2009 influenza A(H1N1) illness and the association with early antiviral treatment among pregnant women in the United States. Design, Setting, and Patients Surveillance of 2009 influenza A(H1N1) in pregnant women reported to the Centers for Disease Control and Prevention (CDC) with symptom onset from April through December 2009. Main Outcome Measures Severity of illness (hospitalizations, intensive care unit [ICU] admissions, and deaths) due to 2009 influenza A(H1N1) among pregnant women, stratified by timing of antiviral treatment and pregnancy trimester at symptom onset. Results We received reports on 788 pregnant women in the United States with 2009 influenza A(H1N1) with symptom onset from April through August 2009. Among those, 30 died (5% of all reported 2009 influenza A[ H1N1] influenza deaths in this period). Among 509 hospitalized women, 115 (22.6%) were admitted to an ICU. Pregnant women with treatment more than 4 days after symptom onset were more likely to be admitted to an ICU (56.9% vs 9.4%; relative risk [RR], 6.0; 95% confidence interval [CI], 3.5-10.6) than those treated within 2 days after symptom onset. Only 1 death occurred in a patient who received treatment within 2 days of symptom onset. Updating these data with the CDC's continued surveillance of ICU admissions and deaths among pregnant women with symptom onset through December 31, 2009, identified an additional 165 women for a total of 280 women who were admitted to ICUs, 56 of whom died. Among the deaths, 4 occurred in the first trimester (7.1%), 15 in the second (26.8%), and 36 in the third (64.3%); Conclusions Pregnant women had a disproportionately high risk of mortality due to 2009 influenza A(H1N1). Among pregnant women with 2009 influenza A(H1N1) influenza reported to the CDC, early antiviral treatment appeared to be associated with fewer admissions to an ICU and fewer deaths. JAMA. 2010;303(15):1517-1525 www.jama.com C1 [Rasmussen, Sonja A.; Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Siston, Alicia M.; Nielsen, Carrie F.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Siston, Alicia M.; Fry, Alicia M.; Finelli, Lyn] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Callaghan, William M.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Louie, Janice] Calif Dept Publ Hlth, Richmond, CA USA. [Doyle, Timothy J.] Florida Dept Hlth, Tallahassee, FL USA. [Crockett, Molly] Massachusetts Dept Publ Hlth, Boston, MA USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Moore, Zack] N Carolina Dept Hlth & Human Serv, Raleigh, NC USA. [Wiedeman, Caleb] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Anand, Madhu] New York State Dept Hlth, Albany, NY 12237 USA. [Tabony, Laura] Texas Dept State Hlth Serv, Austin, TX USA. [Nielsen, Carrie F.] Wisconsin Dept Hlth Serv, Madison, WI USA. [Waller, Kirsten] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Page, Shannon] Ohio Dept Hlth, Columbus, OH 43266 USA. [Thompson, Jeannie M.] Oklahoma Dept Hlth, Oklahoma City, OK USA. [Avery, Catherine] New Mexico Dept Hlth, Santa Fe, NM USA. [Springs, Chasisity Brown] S Carolina Dept Hlth & Environm Control, Columbia, SC 29201 USA. [Jones, Timothy] Tennessee Dept Hlth, Nashville, TN USA. RP Honein, MA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM mhonein@cdc.gov NR 55 TC 351 Z9 376 U1 3 U2 14 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 21 PY 2010 VL 303 IS 15 BP 1517 EP 1525 DI 10.1001/jama.2010.479 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 585SJ UT WOS:000276849000028 PM 20407061 ER PT J AU Mathanga, DP Campbell, CH Eng, JV Wolkon, A Bronzan, RN Malenga, GJ Ali, D Desai, M AF Mathanga, Don P. Campbell, Carl H., Jr. Eng, Jodi Vanden Wolkon, Adam Bronzan, Rachel N. Malenga, Grace J. Ali, Doreen Desai, Meghna TI Comparison of anaemia and parasitaemia as indicators of malaria control in household and EPI-health facility surveys in Malawi SO MALARIA JOURNAL LA English DT Article ID CHILDREN; GHANA AB Background: The World Health Organization has recommended that anaemia be used as an additional indicator to monitor malaria burden at the community level as malaria interventions are nationally scaled up. To date, there are no published evaluations of this recommendation. Methods: To evaluate this recommendation, a comparison of anaemia and parasitaemia among 6-30 month old children was made during two repeated cross-sectional household (HH) and health facility (HF) surveys in six districts across Malawi at baseline (2005) and in a follow-up survey (2008) after a scale up of malaria control interventions. Results: HH net ownership did not increase between the years (50.5% vs. 49.8%), but insecticide treated net (ITN) ownership increased modestly from 41.5% (95% CI: 37.2%-45.8%) in 2005 to 45.3% (95% CI: 42.6%-48.0%) in 2008. ITN use by children 6-30 months old, who were living in HH with at least one net, increased from 73.6% (95% CI:68.2%-79.1%) to 80.0% (95% CI:75.9%-84.1%) over the three-year period. This modest increase in ITN use was associated with a decrease in moderate to severe anaemia (Hb <8 g/dl) from 18.4% (95% CI:14.9%-21.8%) in 2005 to 15.4% (13.2%-17.7%) in 2008, while parasitaemia, measured as positive-slide microscopy, decreased from 18.9% (95% CI:14.7%-23.2%) to 16.9% (95% CI:13.8%-20.0%), a relative reduction of 16% and 11%, respectively. In HF surveys, anaemia prevalence decreased from 18.3% (95% CI: 14.9%-21.7%) to 15.4% (95% CI: 12.7%-18.2%), while parasitaemia decreased from 30.6% (95% CI: 25.7%-35.5%) to 13.2% (95% CI: 10.6%-15.8%), a relative reduction of 15% and 57%, respectively. Conclusion: Increasing access to effective malaria prevention was associated with a reduced burden of malaria in young Malawian children. Anaemia measured at the HF level at time of routine vaccination may be a good surrogate indicator for its measurement at the HH level in evaluating national malaria control programmes. C1 [Mathanga, Don P.; Malenga, Grace J.] Univ Malawi, Coll Med, Malaria Alert Ctr, Blantyre 3, Malawi. [Mathanga, Don P.] Univ Malawi, Coll Med, Dept Community Hlth, Blantyre 3, Malawi. [Campbell, Carl H., Jr.; Eng, Jodi Vanden; Wolkon, Adam; Bronzan, Rachel N.; Desai, Meghna] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. RP Mathanga, DP (reprint author), Univ Malawi, Coll Med, Malaria Alert Ctr, P Bag 360, Blantyre 3, Malawi. EM dmathang@mac.medcol.mw FU Ministry of Health, Malawi; College of Medicine; US Centers for Disease Control; President Malaria Initiative; CDC [5 U01 CI000189] FX We thank the parents, guardians and all children involved in this study for their cooperation and participation. We also wish to acknowledge the following people for their support of this project: Dr. Storn Kabuluzi at the Ministry of Health, Malawi and Prof. Cameron Bowie from the College of Medicine. Funding for this study was provided by the US Centers for Disease Control and the President Malaria Initiative. This article was supported by the Cooperative Agreement number 5 U01 CI000189 from the CDC. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the funding agencies. NR 14 TC 16 Z9 16 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 21 PY 2010 VL 9 AR 107 DI 10.1186/1475-2875-9-107 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 592FV UT WOS:000277363200003 PM 20409342 ER PT J AU Frieden, TR Briss, PA AF Frieden, Thomas R. Briss, Peter A. TI We Can Reduce Dietary Sodium, Save Money, and Save Lives SO ANNALS OF INTERNAL MEDICINE LA English DT Editorial Material ID CARDIOVASCULAR-DISEASE; UNITED-STATES; SALT; METAANALYSIS; POPULATION; ADULTS; HEALTH C1 [Frieden, Thomas R.; Briss, Peter A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS D-14, Atlanta, GA 30333 USA. NR 20 TC 12 Z9 12 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 20 PY 2010 VL 152 IS 8 BP 526 EP U70 DI 10.7326/0003-4819-152-8-201004200-00214 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 588FV UT WOS:000277054400007 PM 20194226 ER PT J AU Chang, MH Yesupriya, A Ned, RM Mueller, PW Dowling, NF AF Chang, Man-huei Yesupriya, Ajay Ned, Renee M. Mueller, Patricia W. Dowling, Nicole F. TI Genetic variants associated with fasting blood lipids in the US population: Third National Health and Nutrition Examination Survey SO BMC MEDICAL GENETICS LA English DT Article ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; LDL-CHOLESTEROL LEVELS; OXIDE SYNTHASE GENE; BETA(3)-ADRENERGIC RECEPTOR GENE; APOLIPOPROTEIN-E POLYMORPHISM; CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME AB Background: The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. Methods: Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). Results: Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. In non-Hispanic whites, no individual polymorphisms were associated with any lipid trait. However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. In non-Hispanic blacks, APOE variant rs7412 and haplotype T-T were strongly associated with LDL-C and TC; whereas, rs5918 of ITGB3 was significantly associated with TG. Several variants and haplotypes of three genes were significantly related to lipids in Mexican Americans: PON1 in relation to HDL-C; APOE and NOS3 in relation to LDL-C; and APOE in relation to TC. Conclusions: We report the significant associations of blood lipids with variants and haplotypes in APOE, ITGB3, NOS3, and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. C1 [Chang, Man-huei; Yesupriya, Ajay; Ned, Renee M.; Dowling, Nicole F.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Mueller, Patricia W.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Chang, MH (reprint author), Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30333 USA. EM mchang@cdc.gov RI Ned, Renee/D-3746-2009 NR 106 TC 21 Z9 23 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2350 J9 BMC MED GENET JI BMC Med. Genet. PD APR 20 PY 2010 VL 11 AR 62 DI 10.1186/1471-2350-11-62 PG 13 WC Genetics & Heredity SC Genetics & Heredity GA 603GT UT WOS:000278197400001 PM 20406466 ER PT J AU Kelley, GA Kelley, KS Hootman, JM Jones, DL AF Kelley, George A. Kelley, Kristi S. Hootman, Jennifer M. Jones, Dina L. TI Exercise and global well-being in community-dwelling adults with fibromyalgia: a systematic review with meta-analysis SO BMC PUBLIC HEALTH LA English DT Article ID AMERICAN-HEART-ASSOCIATION; OF-SPORTS-MEDICINE; HEALTH-CARE COSTS; CLINICAL-TRIALS; PHYSICAL-ACTIVITY; PUBLIC-HEALTH; QUALITY; WOMEN; STRENGTH; BIAS AB Background: Exercise has been recommended for improving global-well being in adults with fibromyalgia. However, no meta-analysis has determined the effects of exercise on global well-being using a single instrument and when analyzed separately according to intention-to-treat and per-protocol analyses. The purpose of this study was to fill that gap. Methods: Studies were derived from six electronic sources, cross-referencing from retrieved studies and expert review. Dual selection of randomized controlled exercise training studies published between January 1, 1980 and January 1, 2008 and in which global well-being was assessed using the Fibromyalgia Impact Questionnaire (FIQ) were included. Dual abstraction of data for study, subject and exercise program characteristics as well as assessment of changes in global well-being using the total score from the FIQ was conducted. Risk of bias was assessed using the Cochrane bias assessment tool. Random-effects models and Hedge's standardized effect size (g) were used to pool results according to per-protocol and intention-to-treat analyses. Results: Of 1,025 studies screened, 7 representing 5 per-protocol and 5 intention-to-treat outcomes in 473 (280 exercise, 193 control) primarily female (99%) participants 18-73 years of age were included. Small, statistically significant improvements in global well-being were observed for per-protocol (g and 95% confidence interval, -0.39, -0.69 to -0.08) and intention-to-treat (-0.34, -0.53 to -0.14) analyses. No statistically significant within-group heterogeneity was found (per-protocol, Q(w) = 6.04, p = 0.20, I-2 = 33.8%; intention-to-treat, Q(w) = 3.19, p = 0.53, I-2 = 0%) and no between-group differences for per-protocol and intention-to-treat outcomes were observed (Q(b) = 0.07, p = 0.80). Changes were equivalent to improvements of 8.2% for per-protocol analyses and 7.3% for intention-to-treat analyses. Conclusions: The results of this study suggest that exercise improves global well-being in community-dwelling women with fibromyalgia. However, additional research on this topic is needed, including research in men as well as optimal exercise programs for improving global well-being in adults. C1 [Kelley, George A.; Kelley, Kristi S.] W Virginia Univ, Dept Community Med, Morgantown, WV 26506 USA. [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Jones, Dina L.] W Virginia Univ, Dept Orthopaed, Morgantown, WV 26506 USA. [Jones, Dina L.] W Virginia Univ, Div Phys Therapy, Morgantown, WV 26506 USA. RP Kelley, GA (reprint author), W Virginia Univ, Dept Community Med, Morgantown, WV 26506 USA. EM gkelley@hsc.wvu.edu FU Centers for Disease Control and Prevention through the Association of American Medical Colleges [U36/CCU319276]; AAMC [MM-0944-06/06] FX This study was supported under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of American Medical Colleges, grant number U36/CCU319276, AAMC ID number MM-0944-06/06. Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 46 TC 27 Z9 27 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD APR 20 PY 2010 VL 10 AR 198 DI 10.1186/1471-2458-10-198 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 604BK UT WOS:000278252100001 PM 20406476 ER PT J AU Gilmore, RD Howison, RR Dietrich, G Patton, TG Clifton, DR Carroll, JA AF Gilmore, Robert D., Jr. Howison, Rebekah R. Dietrich, Gabrielle Patton, Toni G. Clifton, Dawn R. Carroll, James A. TI The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID OUTER-SURFACE PROTEIN; HOST-SPECIFIC SIGNALS; IXODES-SCAPULARIS; LIFE-CYCLE; EXPRESSION; SPIROCHETE; VECTOR; MICE; MEMBRANE; OSPC AB The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood. In this study, we demonstrate that a B. burgdorferi mutant strain deficient in the synthesis of the bba64 gene product was incapable of infecting mice via tick bite even though the mutant was (i) infectious in mice when introduced by needle inoculation, (ii) acquired by larval ticks feeding on infected mice, and (iii) able to persist through tick molting stages. This finding of a B. burgdorferi gene required for pathogen transfer and/or survival from the tick to the susceptible host represents an important breakthrough toward understanding transmission mechanisms involved for the Lyme disease agent. C1 [Gilmore, Robert D., Jr.; Howison, Rebekah R.; Dietrich, Gabrielle; Patton, Toni G.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Bacterial Dis Branch, Ft Collins, CO 80521 USA. [Clifton, Dawn R.; Carroll, James A.] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA 15261 USA. RP Gilmore, RD (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Bacterial Dis Branch, Ft Collins, CO 80521 USA. EM rbg9@cdc.gov NR 54 TC 30 Z9 30 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 20 PY 2010 VL 107 IS 16 BP 7515 EP 7520 DI 10.1073/pnas.1000268107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 586FU UT WOS:000276892300073 PM 20368453 ER PT J AU Schymura, MJ Kahn, AR German, RR Hsieh, MC Cress, RD Finch, JL Fulton, JP Shen, TF Stuckart, E AF Schymura, Maria J. Kahn, Amy R. German, Robert R. Hsieh, Mei-Chin Cress, Rosemary D. Finch, Jack L. Fulton, John P. Shen, Tiefu Stuckart, Erik TI Factors associated with initial treatment and survival for clinically localized prostate cancer: results from the CDC-NPCR Patterns of Care Study (PoC1) SO BMC CANCER LA English DT Article ID ANDROGEN DEPRIVATION THERAPY; QUALITY-OF-LIFE; RADICAL PROSTATECTOMY; RANDOMIZED-TRIAL; UNITED-STATES; TREATMENT DECISIONS; RACIAL-DIFFERENCES; VETERANS AFFAIRS; AFRICAN-AMERICAN; OUTCOMES AB Background: Despite the large number of men diagnosed with localized prostate cancer, there is as yet no consensus concerning appropriate treatment. The purpose of this study was to describe the initial treatment patterns for localized prostate cancer in a population-based sample and to determine the clinical and patient characteristics associated with initial treatment and overall survival. Methods: The analysis included 3,300 patients from seven states, diagnosed with clinically localized prostate cancer in 1997. We examined the association of sociodemographic and clinical characteristics with four treatment options: radical prostatectomy, radiation therapy, hormone therapy, and watchful waiting. Diagnostic and treatment information was abstracted from medical records. Socioeconomic measures were derived from the 2000 Census based on the patient's residence at time of diagnosis. Vital status through December 31, 2002, was obtained from medical records and linkages to state vital statistics files and the National Death Index. Multiple logistic regression analysis and Cox proportional hazards models identified factors associated with initial treatment and overall survival, respectively. Results: Patients with clinically localized prostate cancer received the following treatments: radical prostatectomy (39.7%), radiation therapy (31.4%), hormone therapy (10.3%), or watchful waiting (18.6%). After multivariable adjustment, the following variables were associated with conservative treatment ( hormone therapy or watchful waiting): older age, black race, being unmarried, having public insurance, having non-screen detected cancer, having normal digital rectal exam results, PSA values above 20, low Gleason score (2-4), comorbidity, and state of residence. Among patients receiving definitive treatment (radical prostatectomy or radiation therapy), older age, being unmarried, PSA values above 10, unknown Gleason score, state of residence, as well as black race in patients under 60 years of age, were associated with receipt of radiation therapy. Overall survival was related to younger age, being married, Gleason score under 8, radical prostatectomy, and state of residence. Comorbidity was only associated with risk of death within the first three years of diagnosis. Conclusions: In the absence of clear-cut evidence favoring one treatment modality over another, it is important to understand the factors that inform treatment selection. Since state of residence was a significant predictor of both treatment as well as overall survival, true regional differences probably exist in how physicians and patients select treatment options. Factors affecting treatment choice and treatment effectiveness need to be further explored in future population-based studies. C1 [Schymura, Maria J.; Kahn, Amy R.] New York State Dept Hlth, New York State Canc Registry, Menands, NY 12204 USA. [German, Robert R.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Hsieh, Mei-Chin] Louisiana State Univ, Hlth Sci Ctr, Louisiana Tumor Registry, New Orleans, LA USA. [Cress, Rosemary D.] Inst Publ Hlth, Calif Canc Registry, Sacramento, CA USA. [Finch, Jack L.] Colorado Dept Publ Hlth & Environm, Colorado Cent Canc Registry, Denver, CO USA. [Fulton, John P.] Rhode Isl Dept Hlth, Rhode Isl Canc Registry, Providence, RI 02908 USA. [Shen, Tiefu] Illinois Dept Publ Hlth, Div Epidemiol Studies, Springfield, IL 62761 USA. [Stuckart, Erik] S Carolina Dept Hlth & Environm Control, S Carolina Cent Canc Registry, Columbia, SC 29201 USA. RP Schymura, MJ (reprint author), New York State Dept Hlth, New York State Canc Registry, 150 Broadway,Suite 361, Menands, NY 12204 USA. EM mjs08@health.state.ny.us NR 55 TC 35 Z9 37 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2407 J9 BMC CANCER JI BMC Cancer PD APR 19 PY 2010 VL 10 AR 152 DI 10.1186/1471-2407-10-152 PG 15 WC Oncology SC Oncology GA 605RG UT WOS:000278364100001 PM 20403178 ER PT J AU Rao, JK Anderson, LA Sukumar, B Beauchesne, DA Stein, T Frankel, RM AF Rao, Jaya K. Anderson, Lynda A. Sukumar, Bhuvana Beauchesne, Danielle A. Stein, Terry Frankel, Richard M. TI Engaging communication experts in a Delphi process to identify patient behaviors that could enhance communication in medical encounters SO BMC HEALTH SERVICES RESEARCH LA English DT Article ID HEALTH-SERVICES RESEARCH; SHARED DECISION-MAKING; CONSENSUS METHODS; CARE; INVOLVEMENT; PARTICIPATION; GUIDELINES; EDUCATION; ILLNESS; LESSONS AB Background: The communication literature currently focuses primarily on improving physicians' verbal and nonverbal behaviors during the medical interview. The Four Habits Model is a teaching and research framework for physician communication that is based on evidence linking specific communication behaviors with processes and outcomes of care. The Model conceptualizes basic communication tasks as "Habits" and describes the sequence of physician communication behaviors during the clinical encounter associated with improved outcomes. Using the Four Habits Model as a starting point, we asked communication experts to identify the verbal communication behaviors of patients that are important in outpatient encounters. Methods: We conducted a 4-round Delphi process with 17 international experts in communication research, medical education, and health care delivery. All rounds were conducted via the internet. In round 1, experts reviewed a list of proposed patient verbal communication behaviors within the Four Habits Model framework. The proposed patient verbal communication behaviors were identified based on a review of the communication literature. The experts could: approve the proposed list; add new behaviors; or modify behaviors. In rounds 2, 3, and 4, they rated each behavior for its fit (agree or disagree) with a particular habit. After each round, we calculated the percent agreement for each behavior and provided these data in the next round. Behaviors receiving more than 70% of experts' votes (either agree or disagree) were considered as achieving consensus. Results: Of the 14 originally-proposed patient verbal communication behaviors, the experts modified all but 2, and they added 20 behaviors to the Model in round 1. In round 2, they were presented with 59 behaviors and 14 options to remove specific behaviors for rating. After 3 rounds of rating, the experts retained 22 behaviors. This set included behaviors such as asking questions, expressing preferences, and summarizing information. Conclusion: The process identified communication tasks and verbal communication behaviors for patients similar to those outlined for physicians in the Four Habits Model. This represents an important step in building a single model that can be applied to teaching patients and physicians the communication skills associated with improved satisfaction and positive outcomes of care. C1 [Rao, Jaya K.] Univ N Carolina, Eshelman Sch Pharm, Div Pharmaceut Outcomes & Policy, Chapel Hill, NC 27599 USA. [Anderson, Lynda A.] Ctr Dis Control & Prevent, Healthy Ageing Program, Atlanta, GA 30341 USA. [Sukumar, Bhuvana; Beauchesne, Danielle A.] ICF Macro Int Inc, Atlanta, GA 30329 USA. [Stein, Terry] Kaiser Permanente No Calif, Permanente Med Grp, Oakland, CA 94612 USA. [Frankel, Richard M.] Roudebush VA Med Ctr, Ctr Implementing Evidence Based Practice, Indianapolis, IN 46202 USA. RP Rao, JK (reprint author), Univ N Carolina, Eshelman Sch Pharm, Div Pharmaceut Outcomes & Policy, 2202 Kerr Hall,CB 7573, Chapel Hill, NC 27599 USA. EM jayarao@unc.edu FU Centers for Disease Control and Prevention [200-2007-M-21989]; ICF Macro International [200-2007-M-21989] FX Dr Sukumar and Ms. Beauchesne were supported through a contract between the Centers for Disease Control and Prevention and ICF Macro International (Contract Number: 200-2007-M-21989). Drs Rao, Anderson, Stein, and Frankel did not have a financial relationship with ICF Macro International. NR 33 TC 7 Z9 7 U1 4 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD APR 19 PY 2010 VL 10 AR 97 DI 10.1186/1472-6963-10-97 PG 15 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 625ED UT WOS:000279876400001 PM 20403173 ER PT J AU Whaley, MJ Sampson, JS Johnson, SE Rajam, G Stinson-Parks, A Holder, P Mauro, E Romero-Steiner, S Carlone, GM Ades, EW AF Whaley, Melissa J. Sampson, Jacquelyn S. Johnson, Scott E. Rajam, Gowrisankar Stinson-Parks, Annie Holder, Patricia Mauro, Erica Romero-Steiner, Sandra Carlone, George M. Ades, Edwin W. TI Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model SO VACCINE LA English DT Article DE Pneumococcal vaccines; Non-interference; Expanded vaccine coverage ID PNEUMOCOCCAL CONJUGATE VACCINE; LINKED-IMMUNOSORBENT-ASSAY; SURFACE ADHESIN-A; MOUSE MODEL; NASOPHARYNGEAL COLONIZATION; ANTICAPSULAR ANTIBODIES; MONOCLONAL-ANTIBODIES; NONVACCINE SEROTYPES; SERUM ANTIBODY; UNITED-STATES AB A murine colonization model was used to determine the effect of co-administering 7-valent polysaccharide-protein conjugate vaccine and pneumococcal surface adhesin A. Mice were challenged intranasally with either PCV7 serotypes, 4 or 14, or a non-PCV7 serotype, 19A. Post-challenge samples were evaluated for IgG antibody levels, opsonophagocytic activity, and nasopharyngeal colonization. No interference was observed between immune responses from the concomitant and individual immunizations. Concomitant immunizations reduced carriage for tested serotypes; largest reduction was observed for 19A. From these mouse studies, co-administering pneumococcal antigens appear to expand coverage and reduce colonization against a non-PCV7 serotype without inhibiting immunogenicity to other serotypes. Published by Elsevier Ltd. C1 [Whaley, Melissa J.; Sampson, Jacquelyn S.; Johnson, Scott E.; Rajam, Gowrisankar; Stinson-Parks, Annie; Holder, Patricia; Mauro, Erica; Romero-Steiner, Sandra; Carlone, George M.; Ades, Edwin W.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA 30333 USA. RP Whaley, MJ (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, 1600 Clifton Rd NE,MS G-05, Atlanta, GA 30333 USA. EM mwhaley@cdc.gov OI Romero-Steiner, Sandra/0000-0003-4128-7768 FU CDC FX This research was supported in part by an appointment of M.J. Whaley to the Emerging Infectious Diseases Fellowship Program administered by the Association of Public Health Laboratories and funded by CDC. We thank Yvonne Reed and Kay Montgomery for the daily care of the animals and sharing their expertise. The findings of this study are those of the authors and do not necessarily represent the views of CDC. NR 61 TC 13 Z9 15 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 19 PY 2010 VL 28 IS 18 BP 3071 EP 3075 DI 10.1016/j.vaccine.2010.02.086 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 588JA UT WOS:000277064500001 PM 20206671 ER PT J AU Lima, JC Banic, DM Tran, TM Meyer, VSE De-Simone, SG Santos, F Porto, LCS Marques, MTQ Moreno, A Barnwell, JW Galinski, MR Oliveira-Ferreira, J AF Lima-Junior, J. C. Banic, D. M. Tran, T. M. Meyer, V. S. E. De-Simone, S. G. Santos, F. Porto, L. C. S. Marques, M. T. Q. Moreno, A. Barnwell, J. W. Galinski, M. R. Oliveira-Ferreira, J. TI Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN-gamma and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon SO VACCINE LA English DT Article DE Plasmodium vivax; Merozoite surface protein 9; Promiscuous T-cell epitopes ID MULTIPLE ANTIGEN PEPTIDES; CLASS-II ALLELES; IMMUNE-RESPONSES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; BINDING PREDICTION; INTERFERON-GAMMA; HELPER EPITOPES; FALCIPARUM; VIVAX AB Plasmodium vivax merozoite surface protein (PvMSP9) stimulates both cellular and humoral immune responses in individuals who are naturally infected by this parasite species. To identify immunodominant human T-cell epitopes in PvMSP9, we used the MHC class II binding peptide prediction algorithm ProPred. Eleven synthetic peptides representing predicted putative promiscuous T-cell epitopes were tested in IFN-gamma and IL-4 ELISPOT assays using peripheral blood mononuclear cells (PBMC) derived from 142 individuals from Rondonia State, Brazil who had been naturally exposed to P. vivax infections. To determine whether the predicted epitopes are preferentially recognized in the context of multiple alleles, MHC Class II typing of the cohort was also performed. Five synthetic peptides elicited robust cellular responses, and the overall frequencies of IFN-gamma and IL-4 responders to at least one of the promiscuous peptides were 62% and 46%, respectively. The frequencies of IFN-gamma and IL-4 responders to each peptide were not associated with a particular HLA-DRB1 allelic group since most of the peptides induced a response in individuals of 12 out of 13 studied allelic groups. The prediction of promiscuous epitopes using ProPred led to the identification of immunodominant epitopes recognized by PBMC from a significant proportion of a genetically heterogeneous population exposed to malaria infections. The combination of several such T-cell epitopes in a vaccine construct may increase the frequency of responders and the overall efficacy of subunit vaccines in genetically distinct populations. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Lima-Junior, J. C.; Oliveira-Ferreira, J.] Fiocruz MS, Inst Oswaldo Cruz, Lab Immunoparasitol, BR-21045900 Rio De Janeiro, Brazil. [Banic, D. M.] Fiocruz MS, Inst Oswaldo Cruz, Malaria Res Lab, BR-21045900 Rio De Janeiro, Brazil. [Tran, T. M.; Meyer, V. S. E.; Moreno, A.; Galinski, M. R.] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [De-Simone, S. G.] Fiocruz MS, Inst Oswaldo Cruz, Lab Biochem Prot & Peptides, BR-21045900 Rio De Janeiro, Brazil. [De-Simone, S. G.] Univ Fed Fluminense, Inst Biol, Dept Biochem & Mol Biol, Rio De Janeiro, Brazil. [Santos, F.] LACEN, Dept Entomol, Porto Velho, RO, Brazil. [Porto, L. C. S.; Marques, M. T. Q.] Univ Estado Rio De Janeiro, Lab Histocompatibil & Cryopreservat, Rio De Janeiro, Brazil. [Moreno, A.; Galinski, M. R.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Barnwell, J. W.] CDC, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. RP Oliveira-Ferreira, J (reprint author), Fiocruz MS, Inst Oswaldo Cruz, Lab Immunoparasitol, Pavilhao Leonidas Deane,4th Floor,Av Brasil 4365, BR-21045900 Rio De Janeiro, Brazil. EM lila@ioc.fiocruz.br RI Porto, Luis Cristovao/I-2984-2013; Lima-Junior, Josue /B-1361-2014; Oliveira-Ferreira, Joseli/E-7942-2014; OI Porto, Luis Cristovao/0000-0003-1499-1821; Lima-Junior, Josue /0000-0002-5848-404X; Oliveira-Ferreira, Joseli/0000-0002-6063-465X; De-Simone, Salvatore/0000-0002-2172-656X FU Brazilian National Research Council-CNPq/PAPES; Fiocruz; National Institute of Health; National Institutes of Health [RR00165, RO1 AI0555994] FX This work was supported by Brazilian National Research Council-CNPq/PAPES, Fiocruz, National Institute of Health, the Yerkes National Primate Research Center Base Grant #RR00165 awarded by the National Center for Research Resources of the National Institutes of Health, and NIH Grant #RO1 AI0555994. Josue da Costa Lima Junior was the recipient of a CNPq Fellowship. We are grateful to all individuals that participate in this study for their cooperation and generous donation of blood, which made this study possible. We thank Eileen Farnon and Jennie Larson for the assistance during the sample collection. We thank the Secretary of Health of Rondonia State and the Laboratorio Central-LACEN of Rondonia for providing fieldwork support and the Program for Technological Development in Tools for Health-PDTIS/FIOCRUZ for use of its facilities. NR 49 TC 13 Z9 13 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD APR 19 PY 2010 VL 28 IS 18 BP 3185 EP 3191 DI 10.1016/j.vaccine.2010.02.046 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 588JA UT WOS:000277064500016 PM 20189487 ER PT J AU Smith, JC AF Smith, Jean Clare TI The structure, role, and procedures of the US Advisory Committee on Immunization Practices (ACIP) SO VACCINE LA English DT Article DE Immunization; Decision making; Evidence based ID UNITED-STATES; ROTAVIRUS AB The National Immunization Technical Advisory Group (NITAG) in the United States is the Advisory Committee on Immunization Practices (ACIP). The ACIP was established in 1964 by the US Surgeon General to assist in the prevention and control of communicable diseases, and includes a chair, an executive secretary, 15 voting members, 8 ex officio members and liaison representatives from 26 health-related professional organizations. Meetings are regularly convened at the Centers for Disease Control and Prevention (CDC) and are open to the public. Stringent measures and rigorous screening are used to avoid both real and apparent conflicts of interest, and no special interest or lobbying groups provide any material support to ACIP or its members. The committee recommends licensed new vaccines to be incorporated into the routine immunization schedule, recommends vaccine formulations, and reviews older vaccines to consider revising its recommendations. Published by Elsevier Ltd. C1 Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Smith, JC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,NE Mailstop E-05, Atlanta, GA 30333 USA. EM jis6@cdc.gov NR 14 TC 24 Z9 25 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 19 PY 2010 VL 28 SU 1 BP A68 EP A75 DI 10.1016/j.vaccine.2010.02.037 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 600FE UT WOS:000277969200014 PM 20413002 ER PT J AU Kahn, R Alperin, P Eddy, D Borch-Johnsen, K Buse, J Feigelman, J Gregg, E Holman, RR Kirkman, MS Stern, M Tuomilehto, J Wareham, NJ AF Kahn, Richard Alperin, Peter Eddy, David Borch-Johnsen, Knut Buse, John Feigelman, Justin Gregg, Edward Holman, Rury R. Kirkman, M. Sue Stern, Michael Tuomilehto, Jaakko Wareham, Nick J. TI Age at initiation and frequency of screening to detect type 2 diabetes: a cost-effectiveness analysis SO LANCET LA English DT Article ID BLOOD-GLUCOSE CONTROL; QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; MELLITUS; COMPLICATIONS; PREVENTION; MODEL; ARCHIMEDES; HEALTH; ADULTS AB Background No clinical trials have assessed the effects or cost-effectiveness of sequential screening strategies to detect new cases of type 2 diabetes. We used a mathematical model to estimate the cost-effectiveness of several screening strategies. Methods We used person-specific data from a representative sample of the US population to create a simulated population of 325 000 people aged 30 years without diabetes. We used the Archimedes model to compare eight simulated screening strategies for type 2 diabetes with a no-screening control strategy. Strategies differed in terms of age at initiation and frequency of screening. Once diagnosed, diabetes treatment was simulated in a standard manner. We calculated the effects of each strategy on the incidence of type 2 diabetes, myocardial infarction, stroke, and microvascular complications in addition to quality of life, costs, and cost per quality-adjusted life-year (QALY). Findings Compared with no screening, all simulated screening strategies reduced the incidence of myocardial infarction (3-9 events prevented per 1000 people screened) and diabetes-related microvascular complications (3-9 events prevented per 1000 people), and increased the number of QALYs (93-194 undiscounted QALYs) added over 50 years. Most strategies prevented a significant number of simulated deaths (2-5 events per 1000 people). There was little or no effect of screening on incidence of stroke (0-1 event prevented per 1000 people). Five screening strategies had costs per QALY of about US$10 500 or less, whereas costs were much higher for screening started at 45 years of age and repeated every year ($15 509), screening started at 60 years of age and repeated every 3 years ($25738), or a maximum screening strategy (screening started at 30 years of age and repeated every 6 months; $40 778). Several strategies differed substantially in the number of QALYs gained. Costs per QALY were sensitive to the disutility assigned to the state of having diabetes diagnosed with or without symptoms. Interpretation In the US population, screening for type 2 diabetes is cost effective when started between the ages of 30 years and 45 years, with screening repeated every 3-5 years. C1 [Kahn, Richard; Kirkman, M. Sue] Amer Diabet Assoc, Alexandria, VA USA. [Alperin, Peter; Eddy, David; Feigelman, Justin] Archimedes, San Francisco, CA USA. [Borch-Johnsen, Knut] Steno Diabet Ctr, DK-2820 Gentofte, Denmark. [Buse, John] Univ N Carolina, Sch Med, Dept Med, Div Endocrinol, Chapel Hill, NC USA. [Gregg, Edward] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Holman, Rury R.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Diabet Trials Unit, Oxford, England. [Stern, Michael] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Tuomilehto, Jaakko] Univ Helsinki, Hjelt Inst, Helsinki, Finland. [Wareham, Nick J.] Addenbrookes Hosp, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England. RP Kahn, R (reprint author), 1701 N Beauregard St, Alexandria, VA 22311 USA. EM rak6200@gmail.com OI Buse, John/0000-0002-9723-3876 FU Novo Nordisk; Bayer HealthCare; Pfizer FX Novo Nordisk, Bayer HealthCare, and Pfizer. NR 45 TC 109 Z9 112 U1 1 U2 24 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD APR 17 PY 2010 VL 375 IS 9723 BP 1365 EP 1374 DI 10.1016/S0140-6736(09)62162-0 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 588GW UT WOS:000277057800027 PM 20356621 ER PT J AU Molins, CR Delorey, MJ Yockey, BM Young, JW Sheldon, SW Reese, SM Schriefer, ME Petersen, JM AF Molins, Claudia R. Delorey, Mark J. Yockey, Brook M. Young, John W. Sheldon, Sarah W. Reese, Sara M. Schriefer, Martin E. Petersen, Jeannine M. TI Virulence Differences Among Francisella tularensis Subsp tularensis Clades in Mice SO PLOS ONE LA English DT Article ID UNITED-STATES; TULAREMIA; STRAINS AB Francisella tularensis subspecies tularensis (type A) and holarctica (type B) are of clinical importance in causing tularemia. Molecular typing methods have further separated type A strains into three genetically distinct clades, A1a, A1b and A2. Epidemiological analyses of human infections in the United States suggest that A1b infections are associated with a significantly higher mortality rate as compared to infections caused by A1a, A2 and type B. To determine if genetic differences as defined by molecular typing directly correlate with differences in virulence, A1a, A1b, A2 and type B strains were compared in C57BL/6 mice. Here we demonstrate significant differences between survival curves for infections caused by A1b versus A1a, A2 and type B, with A1b infected mice dying earlier than mice infected with A1a, A2 or type B; these results were conserved among multiple strains. Differences were also detected among type A clades as well as between type A clades and type B with respect to bacterial burdens, and gross anatomy in infected mice. Our results indicate that clades defined within F. tularensis subsp. tularensis by molecular typing methods correlate with virulence differences, with A1b strains more virulent than A1a, A2 and type B strains. These findings indicate type A strains are not equivalent with respect to virulence and have important implications for public health as well as basic research programs. C1 [Molins, Claudia R.; Delorey, Mark J.; Yockey, Brook M.; Young, John W.; Sheldon, Sarah W.; Reese, Sara M.; Schriefer, Martin E.; Petersen, Jeannine M.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. RP Molins, CR (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. EM JPetersen@cdc.gov FU American Society for Microbiology and Coordinating Center; Association of Public Health Laboratories FX Claudia R. Molins was funded by the American Society for Microbiology and Coordinating Center for Infectious Diseases as a postdoctoral fellow. Sara M. Reese is an Emerging Infectious Disease Research Fellow funded by the Association of Public Health Laboratories. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 29 Z9 29 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 16 PY 2010 VL 5 IS 4 AR e10205 DI 10.1371/journal.pone.0010205 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 584HZ UT WOS:000276743500015 PM 20419133 ER PT J AU Moonesinghe, R Yesupriya, A Chang, MH Dowling, NF Khoury, MJ Scott, AJ AF Moonesinghe, Ramal Yesupriya, Ajay Chang, Man-huei Dowling, Nicole F. Khoury, Muin J. Scott, Alastair J. CA CDC NCI NHANES III Genomics Workin TI A Hardy-Weinberg Equilibrium Test for Analyzing Population Genetic Surveys With Complex Sample Designs SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE complex survey design; design effect; genetic association studies; Hardy-Weinberg equilibrium ID DISEQUILIBRIUM; ASSOCIATION; DEVIATIONS; GOODNESS; POWER; FIT; LAW AB Testing for deviations from Hardy-Weinberg equilibrium is a widely recommended practice for population-based genetic association studies. However, current methods for this test assume a simple random sample and may not be appropriate for sample surveys with complex survey designs In this paper, the authors present a test for Hardy-Weinberg equilibrium that adjusts for the sample weights and correlation of data collected in complex surveys The authors perform this test by using a simple adjustment to procedures developed to analyze data from complex survey designs available within the SAS statistical software package (SAS Institute, Inc., Cary, North Carolina) Using 90 genetic markers from the Third National Health and Nutrition Examination Survey, the authors found that survey-adjusted and -unadjusted estimates of the disequilibnum coefficient were generally similar within self-reported races/ethnicities. However, estimates of the variance of the disequilibnum coefficient were significantly different between the 2 methods. Because the results of the survey-adjusted tests account for correlation among participants sampled within the same cluster, and the possibility of having related individuals sampled from the same household, the authors recommend use of this test when analyzing genetic data originating from sample surveys with complex survey designs to assess deviations from Hardy-Weinberg equilibrium C1 [Moonesinghe, Ramal] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA 30341 USA. [Yesupriya, Ajay; Chang, Man-huei; Dowling, Nicole F.; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30341 USA. [Scott, Alastair J.] Univ Auckland, Dept Stat, Auckland 1, New Zealand. RP Moonesinghe, R (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, 4770 Buford Highway,Mailstop E-67, Atlanta, GA 30341 USA. NR 31 TC 4 Z9 4 U1 1 U2 15 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD APR 15 PY 2010 VL 171 IS 8 BP 932 EP 941 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 588NO UT WOS:000277078300011 PM 20237153 ER PT J AU Gurley, ES Zaman, RU Sultana, R Bell, M Fry, AM Srinivasan, A Rahman, M Rahman, MW Hossain, MJ Luby, SP AF Gurley, Emily S. Zaman, Rashid Uz Sultana, Rebeca Bell, Michael Fry, Alicia M. Srinivasan, Arjun Rahman, Mahmudur Rahman, M. Waliur Hossain, M. Jahangir Luby, Stephen P. TI Rates of Hospital-Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low-Cost Pilot Surveillance Strategy SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ACUTE MYOCARDIAL-INFARCTION; SYNCYTIAL VIRUS-INFECTION; NOSOCOMIAL INFECTIONS; DEVELOPING-COUNTRIES; HEART-DISEASE; NIPAH VIRUS; INFLUENZA; OUTBREAK; UNIT; PREVALENCE AB Background. Patients hospitalized in resource-poor health care settings are at increased risk for hospital-acquired respiratory infections due to inadequate infrastructure. Methods. From 1 April 2007 through 31 March 2008, we used a low-cost surveillance strategy to identify new onset of respiratory symptoms in patients hospitalized for >72 h and in health care workers in medicine and pediatric wards at 3 public tertiary care hospitals in Bangladesh. Results. During 46,273 patient-days of observation, we recorded 136 episodes of hospital-acquired respiratory disease, representing 1.7% of all patient hospital admissions; rates by ward ranged from 0.8 to 15.8 cases per 1000 patient-days at risk. We identified 22 clusters of respiratory disease, 3 of which included both patients and health care workers. Of 226 of heath care workers who worked on our surveillance wards, 61 (27%) experienced a respiratory illness during the study period. The cost of surveillance was US$43 per month per ward plus 30 min per day in data collection. Conclusions. Patients on these study wards frequently experienced hospital-acquired respiratory infections, including 1 in every 20 patients hospitalized for >72 h on 1 ward. The surveillance method was useful in calculating rates of hospital-acquired respiratory illness and could be used to enhance capacity to quickly detect outbreaks of respiratory disease in health care facilities where systems for outbreak detection are currently limited and to test interventions to reduce transmission of respiratory pathogens in resource-poor settings. C1 [Rahman, Mahmudur] Govt Bangladesh, Minist Hlth & Family Welf, Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Bell, Michael; Fry, Alicia M.; Srinivasan, Arjun; Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Gurley, ES (reprint author), GPO 128, Dhaka 1000, Bangladesh. EM egurley@icddrb.org RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 FU CDC [U01 CI000298] FX CDC (cooperative agreement U01 CI000298). NR 28 TC 10 Z9 10 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1084 EP 1090 DI 10.1086/651265 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900002 PM 20210642 ER PT J AU Kontoyiannis, DP Marr, KA Park, BJ Alexander, BD Anaissie, EJ Walsh, TJ Ito, J Andes, DR Baddley, JW Brown, JM Brumble, LM Freifeld, AG Hadley, S Herwaldt, LA Kauffman, CA Knapp, K Lyon, GM Morrison, VA Papanicolaou, G Patterson, TF Perl, TM Schuster, MG Walker, R Wannemuehler, KA Wingard, JR Chiller, TM Pappas, PG AF Kontoyiannis, Dimitrios P. Marr, Kieren A. Park, Benjamin J. Alexander, Barbara D. Anaissie, Elias J. Walsh, Thomas J. Ito, James Andes, David R. Baddley, John W. Brown, Janice M. Brumble, Lisa M. Freifeld, Alison G. Hadley, Susan Herwaldt, Loreen A. Kauffman, Carol A. Knapp, Katherine Lyon, G. Marshall Morrison, Vicki A. Papanicolaou, Genovefa Patterson, Thomas F. Perl, Trish M. Schuster, Mindy G. Walker, Randall Wannemuehler, Kathleen A. Wingard, John R. Chiller, Tom M. Pappas, Peter G. TI Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001-2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID RISK-FACTORS; MOLD INFECTIONS; PROPHYLACTIC FLUCONAZOLE; PROGNOSTIC-FACTORS; ASPERGILLOSIS; EPIDEMIOLOGY; AUTOPSY; OUTCOMES; BLOOD AB Background. The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies. Methods. The Transplant Associated Infections Surveillance Network, a network of 23 US transplant centers, prospectively enrolled HSCT recipients with proven and probable IFIs occurring between March 2001 and March 2006. We collected denominator data on all HSCTs preformed at each site and clinical, diagnostic, and outcome information for each IFI case. To estimate trends in IFI, we calculated the 12-month cumulative incidence among 9 sequential subcohorts. Results. We identified 983 IFIs among 875 HSCT recipients. The median age of the patients was 49 years; 60% were male. Invasive aspergillosis (43%), invasive candidiasis (28%), and zygomycosis (8%) were the most common IFIs. Fifty-nine percent and 61% of IFIs were recognized within 60 days of neutropenia and graft-versus-host disease, respectively. Median onset of candidiasis and aspergillosis after HSCT was 61 days and 99 days, respectively. Within a cohort of 16,200 HSCT recipients who received their first transplants between March 2001 and September 2005 and were followed up through March 2006, we identified 718 IFIs in 639 persons. Twelve-month cumulative incidences, based on the first IFI, were 7.7 cases per 100 transplants for matched unrelated allogeneic, 8.1 cases per 100 transplants for mismatched-related allogeneic, 5.8 cases per 100 transplants for matched-related allogeneic, and 1.2 cases per 100 transplants for autologous HSCT. Conclusions. In this national prospective surveillance study of IFIs in HSCT recipients, the cumulative incidence was highest for aspergillosis, followed by candidiasis. Understanding the epidemiologic trends and burden of IFIs may lead to improved management strategies and study design. C1 [Kontoyiannis, Dimitrios P.] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 402, Houston, TX 77030 USA. [Patterson, Thomas F.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Marr, Kieren A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Marr, Kieren A.; Perl, Trish M.] Johns Hopkins Univ, Baltimore, MD USA. [Walsh, Thomas J.] NCI, NIH, Bethesda, MD 20892 USA. [Park, Benjamin J.; Wannemuehler, Kathleen A.; Chiller, Tom M.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Lyon, G. Marshall] Emory Univ, Med Ctr, Atlanta, GA 30322 USA. [Alexander, Barbara D.] Duke Univ, Med Ctr, Durham, NC USA. [Anaissie, Elias J.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Ito, James] City Hope Hosp, Duarte, CA USA. [Brown, Janice M.] Stanford Univ, Med Ctr, Palo Alto, CA 94304 USA. [Andes, David R.] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Baddley, John W.; Pappas, Peter G.] Univ Alabama, Birmingham, AL USA. [Brumble, Lisa M.] Mayo Clin, Jacksonville, FL 32224 USA. [Wingard, John R.] Univ Florida, Gainesville, FL USA. [Freifeld, Alison G.] Univ Nebraska Med Ctr, Omaha, NE USA. [Walker, Randall] Mayo Clin, Coll Med, Rochester, MN USA. [Morrison, Vicki A.] Univ Minnesota, Minneapolis, MN USA. [Morrison, Vicki A.] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA. [Hadley, Susan] Tufts Med Ctr, Boston, MA USA. [Herwaldt, Loreen A.] Univ Iowa, Carver Coll Med, Iowa City, IA USA. [Kauffman, Carol A.] Univ Michigan, Ann Arbor Vet Affairs Hlth Care Syst, Ann Arbor, MI 48109 USA. [Knapp, Katherine] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Papanicolaou, Genovefa] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Schuster, Mindy G.] Univ Penn, Philadelphia, PA 19104 USA. RP Kontoyiannis, DP (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 402, 1515 Holcombe Blvd, Houston, TX 77030 USA. EM dkontoyi@mdanderson.org OI Papanicolaou, Genovefa/0000-0002-2891-079X FU Merck; Pfizer; Schereing-Plough; Astellas; Nektar Therapeutics; Enzon; Centers for Disease Control and Prevention [5U01CI000286-05]; Schering-Plough Research Institute; Enzon Pharmaceuticals FX D. P. K. has received research support and honoraria from Schering-Plough, Pfizer, Astellas Pharma, Enzon Pharmaceuticals, and Merck. P. G. P. has received grant support from Merck, Pfizer, Schereing-Plough, and Astellas and serves as an adhoc advisor for Novartis, Basilea, Merck, Pfizer, and Astellas. D. R. A. has received grant support and serves as an ad hoc advisor for Merck, Pfizer, and Schering-Plough. T. F. P. has received esearch support and honoraria from Merck, Pfizer, Schering-Plough, and Nektar Therapeutics and has served as a consultant for Basilea, Merck, Nektar, and Pfizer. K. A. M. has received grant support from Merck and Enzon and serves as an ad hoc advisor and consultant for Astellas, Basilea, Enzon, Merck, Pfizer, and Schering-Plough. J.I.I. has received honoraria from Astellas, Enzon, Pfizer, and Schering-Plough. V. A. M. is on the speakers' bureau for Amgen, Merck, Pfizer, Schering-Plough, and Celgene. J.R.W. has received honoraria from Pfizer, Astellas, Basilea, and Merck. All other authors: no conflicts.; Centers for Disease Control and Prevention (grant 5U01CI000286-05) and grants from Merck, Astellas, Pfizer, Schering-Plough Research Institute, and Enzon Pharmaceuticals. NR 24 TC 440 Z9 460 U1 4 U2 36 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1091 EP 1100 DI 10.1086/651263 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900003 PM 20218877 ER PT J AU Pappas, PG Alexander, BD Andes, DR Hadley, S Kauffman, CA Freifeld, A Anaissie, EJ Brumble, LM Herwaldt, L Ito, J Kontoyiannis, DP Lyon, GM Marr, KA Morrison, VA Park, BJ Patterson, TF Perl, TM Oster, RA Schuster, MG Walker, R Walsh, TJ Wannemuehler, KA Chiller, TM AF Pappas, Peter G. Alexander, Barbara D. Andes, David R. Hadley, Susan Kauffman, Carol A. Freifeld, Alison Anaissie, Elias J. Brumble, Lisa M. Herwaldt, Loreen Ito, James Kontoyiannis, Dimitrios P. Lyon, G. Marshall Marr, Kieren A. Morrison, Vicki A. Park, Benjamin J. Patterson, Thomas F. Perl, Trish M. Oster, Robert A. Schuster, Mindy G. Walker, Randall Walsh, Thomas J. Wannemuehler, Kathleen A. Chiller, Tom M. TI Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET) SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SOLID-ORGAN; RISK-FACTORS; AMPHOTERICIN-B; ASPERGILLOSIS; KIDNEY; PROPHYLAXIS; CANDIDIASIS; VORICONAZOLE; FLUCONAZOLE AB Background. Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among organ transplant recipients. Multicenter prospective surveillance data to determine disease burden and secular trends are lacking. Methods. The Transplant-Associated Infection Surveillance Network (TRANSNET) is a consortium of 23 US transplant centers, including 15 that contributed to the organ transplant recipient dataset. We prospectively identified IFIs among organ transplant recipients from March, 2001 through March, 2006 at these sites. To explore trends, we calculated the 12-month cumulative incidence among 9 sequential cohorts. Results. During the surveillance period, 1208 IFIs were identified among 1063 organ transplant recipients. The most common IFIs were invasive candidiasis (53%), invasive aspergillosis (19%), cryptococcosis (8%), non-Aspergillus molds (8%), endemic fungi (5%), and zygomycosis (2%). Median time to onset of candidiasis, aspergillosis, and cryptococcosis was 103, 184, and 575 days, respectively. Among a cohort of 16,808 patients who underwent transplantation between March 2001 and September 2005 and were followed through March 2006, a total of 729 IFIs were reported among 633 persons. One-year cumulative incidences of the first IFI were 11.6%, 8.6%, 4.7%, 4.0%, 3.4%, and 1.3% for small bowel, lung, liver, heart, pancreas, and kidney transplant recipients, respectively. One-year incidence was highest for invasive candidiasis (1.95%) and aspergillosis (0.65%). Trend analysis showed a slight increase in cumulative incidence from 2002 to 2005. Conclusions. We detected a slight increase in IFIs during the surveillance period. These data provide important insights into the timing and incidence of IFIs among organ transplant recipients, which can help to focus effective prevention and treatment strategies. C1 [Pappas, Peter G.] Univ Alabama, Dept Med, Div Infect Dis, Med Ctr, Birmingham, AL 35294 USA. [Oster, Robert A.] Univ Alabama, Dept Med, Div Prevent Med, Med Ctr, Birmingham, AL 35294 USA. [Alexander, Barbara D.] Duke Univ, Med Ctr, Durham, NC USA. [Andes, David R.] Univ Wisconsin, Madison, WI 53706 USA. [Hadley, Susan] Tufts Med Ctr, Boston, MA USA. [Kauffman, Carol A.] Univ Michigan, Ann Arbor, MI 48109 USA. [Kauffman, Carol A.] Vet Affairs Ann Arbor Healthcare Syst, Ann Arbor, MI USA. [Freifeld, Alison] Univ Nebraska Med Ctr, Omaha, NE USA. [Anaissie, Elias J.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Brumble, Lisa M.] Mayo Clin, Jacksonville, FL 32224 USA. [Herwaldt, Loreen] Univ Iowa Hosp, Iowa City, IA USA. [Ito, James] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Kontoyiannis, Dimitrios P.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Patterson, Thomas F.] Univ Texas Hlth Sci Ctr San Antonio, S Texas Vet Healthcare Syst, San Antonio, TX 78229 USA. [Lyon, G. Marshall] Emory Univ, Sch Med, Atlanta, GA USA. [Park, Benjamin J.; Wannemuehler, Kathleen A.; Chiller, Tom M.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Marr, Kieren A.; Perl, Trish M.] Johns Hopkins Univ, Med Ctr, Baltimore, MD 21218 USA. [Marr, Kieren A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Morrison, Vicki A.] Univ Minnesota, Minneapolis, MN USA. [Morrison, Vicki A.] Vet Affairs Med Ctr, Minneapolis, MN USA. [Walker, Randall] Mayo Clin, Rochester, MN USA. [Schuster, Mindy G.] Hosp Univ Penn, Philadelphia, PA 19104 USA. [Walsh, Thomas J.] NCI, NIH, Bethesda, MD 20892 USA. RP Pappas, PG (reprint author), Univ Alabama, Dept Med, Div Infect Dis, Med Ctr, 1900 Univ Blvd,229 THT, Birmingham, AL 35294 USA. EM pappas@uab.edu FU Merck; Pfizer; Schereing-Plough; Astellas; Nektar Therapeutics; Enzon FX P. G. P. has received grant support from Merck, Pfizer, Schereing-Plough, and Astellas and served as an adhoc advisor for Novartis, Basilea, Merck, Pfizer, and Astellas. D. R. A. has received grant support and served as an ad hoc advisor for Merck, Pfizer, and Schering-Plough. T. F. P. has received research support and honoraria from Merck, Pfizer, Schering-Plough, and Nektar Therapeutics and has served as a consultant for Basilea, Merck, Nektar, and Pfizer. K. A. M. has received grant support from Merck and Enzon and served as an ad hoc advisor and/or consultant for Astellas, Basilea, Enzon, Merck, Pfizer, and Schering-Plough. J.I.I. has received honoraria from Astellas, Enzon, Pfizer, and Schering-Plough. VAM is on the speakers' bureau for Amgen, Merck, Pfizer, Schering-Plough, and Celgene. All other authors: no conflicts. NR 40 TC 414 Z9 425 U1 2 U2 29 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1101 EP 1111 DI 10.1086/651262 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900004 PM 20218876 ER PT J AU Maier, T Schwarting, A Mauer, D Ross, RS Martens, A Kliem, V Wahl, J Panning, M Baumgarte, S Muller, T Pfefferle, S Ebel, H Schmidt, J Tenner-Racz, K Racz, P Schmid, M Struber, M Wolters, B Gotthardt, D Bitz, F Frisch, L Pfeiffer, N Fickenscher, H Sauer, P Rupprecht, CE Roggendorf, M Haverich, A Galle, P Hoyer, J Drosten, C AF Maier, T. Schwarting, A. Mauer, D. Ross, R. S. Martens, A. Kliem, V. Wahl, J. Panning, M. Baumgarte, S. Mueller, T. Pfefferle, S. Ebel, H. Schmidt, J. Tenner-Racz, K. Racz, P. Schmid, M. Strueber, M. Wolters, B. Gotthardt, D. Bitz, F. Frisch, L. Pfeiffer, N. Fickenscher, H. Sauer, P. Rupprecht, C. E. Roggendorf, M. Haverich, A. Galle, P. Hoyer, J. Drosten, C. TI Management and Outcomes after Multiple Corneal and Solid Organ Transplantations from a Donor Infected with Rabies Virus SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID THERAPEUTIC COMA; FAILURE; BAT; TRANSMISSION; INDUCTION; KETAMINE; RECIPIENTS; APOPTOSIS; VARIANT; MICE AB Background. This article describes multiple transmissions of rabies via transplanted solid organ from a single infected donor. The empirical Milwaukee treatment regimen was used in the recipients. Methods. Symptomatic patients were treated by deep sedation (ketamine, midazolam, and phenobarbital), ribavirin, interferon, and active and passive vaccination. Viral loads and antibodies were continuously monitored. Results. Recipients of both cornea and liver transplants developed no symptoms. The recipient of the liver transplant had been vaccinated similar to 20 years before transplantation. Two recipients of kidney and lung transplants developed rabies and died within days of symptomatic disease. Another kidney recipient was treated 7 weeks before he died. The cerebrospinal fluid viral load remained at constant low levels (<10,000 copies/mL) for similar to 5 weeks; it increased suddenly by almost 5 orders of magnitude thereafter. After death, no virus was found in peripheral compartments (nerve tissue, heart, liver, or the small intestine) in this patient, in contrast to in patients in the same cohort who died early. Conclusions. Our report includes, to our knowledge, the longest documented treatment course of symptomatic rabies and the first time that the virus concentration was measured over time and in different body compartments. The postmortem virus concentration in the periphery was low, but there was no evidence of a reduction of virus in the brain. C1 [Maier, T.; Ebel, H.; Hoyer, J.] Univ Marburg, Med Ctr, Dept Internal Med & Nephrol, Marburg, Germany. [Schwarting, A.; Galle, P.] Johannes Gutenberg Univ Mainz, Med Ctr, Dept Med, Mainz, Germany. [Wahl, J.; Frisch, L.; Pfeiffer, N.] Johannes Gutenberg Univ Mainz, Med Ctr, Dept Ophthalmol, Mainz, Germany. [Mauer, D.; Schmid, M.] German Organ Donor Procurement Org, Neu Isenburg, Germany. [Ross, R. S.; Wolters, B.; Roggendorf, M.] Univ Essen Gesamthsch, Med Ctr, Inst Virol, Essen, Germany. [Martens, A.; Strueber, M.; Haverich, A.] Hannover Med Sch, Clin Cardiac Thorac Transplantat & Vasc Surg, D-3000 Hannover, Germany. [Kliem, V.; Bitz, F.] Nephrol Ctr Lower Saxony, Munden, Germany. [Panning, M.; Pfefferle, S.; Tenner-Racz, K.; Racz, P.; Drosten, C.] Bernhard Nocht Inst Trop Med, Hamburg, Germany. [Baumgarte, S.] Inst Hyg & Environm Med, Hamburg, Germany. [Mueller, T.] Fed Res Inst Anim Hlth, Friedrich Loeffler Inst, Wusterhausen, Germany. [Schmidt, J.] Univ Heidelberg, Dept Surg, Med Ctr, D-6900 Heidelberg, Germany. [Gotthardt, D.; Sauer, P.] Univ Heidelberg, Dept Med, Med Ctr, Liver Transplantat Sect, D-6900 Heidelberg, Germany. [Fickenscher, H.] Univ Heidelberg, Dept Virol, Med Ctr, D-6900 Heidelberg, Germany. [Rupprecht, C. E.] Ctr Dis Control & Prevent, Rabies Sect, Atlanta, GA USA. RP Drosten, C (reprint author), Univ Bonn, Inst Virol, Med Ctr, Sigmund Freud Str 25, D-53105 Bonn, Germany. RI Fickenscher, Helmut/A-3004-2010; Panning, Marcus/I-7889-2016 NR 26 TC 51 Z9 54 U1 0 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2010 VL 50 IS 8 BP 1112 EP 1119 DI 10.1086/651267 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 570BF UT WOS:000275645900005 PM 20205588 ER PT J AU Ford, ES Li, CY Pearson, WS Zhao, GX Mokdad, AH AF Ford, Earl S. Li, Chaoyang Pearson, William S. Zhao, Guixiang Mokdad, Ali H. TI Trends in hypercholesterolemia, treatment and control among United States adults SO INTERNATIONAL JOURNAL OF CARDIOLOGY LA English DT Article DE Cholesterol; Epidemiology; Prevention; Risk factor ID LIPID-LOWERING-THERAPY; CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; HIGH BLOOD CHOLESTEROL; NUTRITION EXAMINATION SURVEY; HEART-DISEASE; NATIONAL-HEALTH; SERUM-CHOLESTEROL; DECISION-SUPPORT; GOAL ATTAINMENT AB Background: Control of hypercholesterolemia is an important clinical and public health objective, yet it is generally poor. The objective of this study was to examine trends in the prevalence of hypercholesterolemia, having a cholesterol check, awareness, treatment, and control among United States adults. Methods: We examined data for 18053 participants aged >= 20 years of the National Health and Nutrition Examination Surveys from 1999 to 2006. Results: The unadjusted prevalence of hypercholesterolemia ranged from 53.2% to 56.1% and changed little over the study period. Significant increases were evident in the percentage of United States adults who had their concentration of cholesterol checked (from 68.6% to 74.8%), who reported being told that they had high hypercholesterolemia (from 42.0% to 50.4%), who reported using cholesterol-lowering medications (from 39.1% to 54.4%), and who had their hypercholesterolemia controlled (from 47.0 to 64.3%). Among all participants with hypercholesterolemia control of hypercholesterolemia increased from 7.2% to 17.1%. Disparities related to gender and race or ethnicity existed, notably a lower rate of control among women than men and lower rates of having a cholesterol check and reporting being told about hypercholesterolemia among African Americans and Mexican Americans than whites. Conclusions: Encouraging increases in awareness, treatment, and control of hypercholesterolemia occurred from 1999 through 2006. Nevertheless, control of hypercholesterolemia remains poor. Published by Elsevier Ireland Ltd. C1 [Ford, Earl S.; Li, Chaoyang; Pearson, William S.; Zhao, Guixiang; Mokdad, Ali H.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K66, Atlanta, GA 30341 USA. EM eford@cdc.gov NR 53 TC 74 Z9 79 U1 0 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-5273 J9 INT J CARDIOL JI Int. J. Cardiol. PD APR 15 PY 2010 VL 140 IS 2 BP 226 EP 235 DI 10.1016/j.ijcard.2008.11.033 PG 10 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 579WG UT WOS:000276407100014 PM 19081646 ER PT J AU Panuwet, P Restrepo, PA Magsumbol, M Jung, KY Montesano, MA Needham, LL Barr, DB AF Panuwet, Parinya Restrepo, Paula A. Magsumbol, Melina Jung, Kyung Y. Montesano, M. Angela Needham, Larry L. Barr, Dana Boyd TI An improved high-performance liquid chromatography-tandem mass spectrometric method to measure atrazine and its metabolites in human urine SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Atrazine; Urine; Mass spectrometry; Metabolites; Biomonitoring ID IN-VITRO METABOLISM; CYTOCHROME-P450 ENZYMES; HUMAN EXPOSURE; RAT; BIOTRANSFORMATION; QUANTIFICATION; PESTICIDES; HERBICIDES; MOUSE AB We report an improved solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry method with isotope dilution quantification to measure seven atrazine metabolites in urine. The metabolites measured were hydroxyatrazine (HA), diaminochloroatrazine (DACT), desisopropylatrazine (DIA), desethylatrazine (DEA), desethylatrazine mercapturate (DEAM), atrazine mercapturate (ATZM), and atrazine (ATZ). Using offline mixed-mode reversed-phase/cation-exchange solid-phase extraction dramatically increased recovery and sensitivity by reducing the influence of matrix components during separation and analysis. DACT extraction recovery improved to greater than 80% while the other analytes had similar extraction efficiencies as previously observed. Limits of detection were lower than our previous method (0.05-0.19 ng/mL) with relative standard deviations less than 10%. The total runtime was shorter (18 min) than the previous on-line method, thus it is suitable for large-scale sample analyses. We increased the throughput of our method twofold by using the newer extraction technique. Published by Elsevier B.V. C1 [Panuwet, Parinya; Magsumbol, Melina; Jung, Kyung Y.; Montesano, M. Angela; Needham, Larry L.; Barr, Dana Boyd] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Restrepo, Paula A.] Battelle Mem Inst, Atlanta, GA USA. RP Barr, DB (reprint author), Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd, Atlanta, GA 30322 USA. EM dbbarr@emory.edu RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; OI Magsumbol, Melina/0000-0002-4904-6427 FU Oak Ridge Institute for Science and Education (ORISE) FX The authors would like to thank the Oak Ridge Institute for Science and Education (ORISE) for providing the fellowship grant to Ms. Magsumbol during 2008-2009. NR 24 TC 10 Z9 11 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD APR 15 PY 2010 VL 878 IS 13-14 BP 957 EP 962 DI 10.1016/j.jchromb.2010.02.025 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 585VT UT WOS:000276859000006 PM 20299293 ER PT J AU Chenine, AL Siddappa, NB Kramer, VG Sciaranghella, G Rasmussen, RA Lee, SJ Santosuosso, M Poznansky, MC Velu, V Amara, RR Souder, C Anderson, DC Villinger, F Else, JG Novembre, FJ Strobert, E O'Neil, SP Secor, WE Ruprecht, RM AF Chenine, Agnes L. Siddappa, Nagadenahalli B. Kramer, Victor G. Sciaranghella, Gaia Rasmussen, Robert A. Lee, Sandra J. Santosuosso, Michael Poznansky, Mark C. Velu, Vijayakumar Amara, Rama R. Souder, Chris Anderson, Daniel C. Villinger, Francois Else, James G. Novembre, Francis J. Strobert, Elizabeth O'Neil, Shawn P. Secor, W. Evan Ruprecht, Ruth M. TI Relative Transmissibility of an R5 Clade C Simian-Human Immunodeficiency Virus Across Different Mucosae in Macaques Parallels the Relative Risks of Sexual HIV-1 Transmission in Humans via Different Routes SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID T-CELL DEPLETION; RHESUS MACAQUES; VAGINAL TRANSMISSION; COITAL ACT; FREE SIV; INFECTION; AIDS; SUSCEPTIBILITY; DISSEMINATION; EXPOSURE AB Background. Worldwide, similar to 90% of all human immunodeficiency virus (HIV) transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV acquisition are highest for rectal, then vaginal, and finally oral exposures. Methods. Mucosal lacerations may affect the rank order of susceptibility to HIV but cannot be assessed in humans. We measured relative virus transmissibility across intact mucosae in macaques using a single stock of SHIV-1157ipd3N4, a simian-human immunodeficiency virus encoding a primary R5 HIV clade C env (SHIV-C). Results. The penetrability of rhesus macaque mucosae differed significantly, with rectal challenge requiring the least virus, followed by vaginal and then oral routes (P = 0.31, oral vs vaginal; P < .001 rectal vs vaginal). These findings imply that intrinsic mucosal properties are responsible for the differential mucosal permeability. The latter paralleled the rank order reported for humans, with relative risk estimates within the range of epidemiological human studies. To test whether inflammation facilitates virus transmission - as predicted from human studies we established a macaque model of localized buccal inflammation. Systemic infection occurred across inflamed but not normal buccal mucosa. Conclusion. Our primate data recapitulate virus transmission risks observed in humans, thus establishing R5 SHIV-1157ipd3N4 in macaques as a robust model system to study cofactors involved in human mucosal HIV transmission and its prevention. C1 [Chenine, Agnes L.; Siddappa, Nagadenahalli B.; Kramer, Victor G.; Sciaranghella, Gaia; Rasmussen, Robert A.; Ruprecht, Ruth M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Chenine, Agnes L.; Siddappa, Nagadenahalli B.; Sciaranghella, Gaia; Rasmussen, Robert A.; Santosuosso, Michael; Poznansky, Mark C.; O'Neil, Shawn P.; Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA USA. [Lee, Sandra J.] Dept Biostat & Computat Biol, Boston, MA USA. [Santosuosso, Michael; Poznansky, Mark C.] Massachusetts Gen Hosp, Partners AIDS Res Ctr & Infect Dis Med, Boston, MA 02114 USA. [O'Neil, Shawn P.] New England Reg Primate Res Ctr, Southborough, MA 01772 USA. [Velu, Vijayakumar; Amara, Rama R.; Souder, Chris; Anderson, Daniel C.; Villinger, Francois; Else, James G.; Novembre, Francis J.; Strobert, Elizabeth] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. RP Ruprecht, RM (reprint author), Dana Farber Canc Inst, 44 Binney St, Boston, MA 02115 USA. EM ruth_ruprecht@dfci.harvard.edu OI Byrareddy, Siddappa /0000-0002-7423-1763; Velu, Vijayakumar/0000-0003-4238-1924 FU NCRR NIH HHS [RR-00165, P51 RR000165]; NIAID NIH HHS [R56 AI062515-01A1, P01 AI048240-08, P01 AI048240, R56 AI062515]; NIDCR NIH HHS [R01 DE016013, R01 DE012937-05, R01 DE012937, R01 DE016013-04] NR 50 TC 36 Z9 38 U1 0 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 15 PY 2010 VL 201 IS 8 BP 1155 EP 1163 DI 10.1086/651274 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 568AJ UT WOS:000275493400008 PM 20214475 ER PT J AU Harrison, LH Shutt, KA Schmink, SE Marsh, JW Harcourt, BH Wang, X Whitney, AM Stephens, DS Cohn, AA Messonnier, NE Mayer, LW AF Harrison, Lee H. Shutt, Kathleen A. Schmink, Susanna E. Marsh, Jane W. Harcourt, Brian H. Wang, Xin Whitney, Anne M. Stephens, David S. Cohn, Amanda A. Messonnier, Nancy E. Mayer, Leonard W. TI Population Structure and Capsular Switching of Invasive Neisseria meningitidis Isolates in the Pre-Meningococcal Conjugate Vaccine Era-United States, 2000-2005 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PNEUMONIAE SEROTYPE 19A; SEROGROUP-C; ZEALANDS EPIDEMIC; DISEASE; INFANTS; STRAIN; FETA; IDENTIFICATION; PREVENTION; INFECTION AB Background. A quadrivalent meningococcal conjugate vaccine (MCV4) was licensed in the United States in 2005; no serogroup B vaccine is available. Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups. Methods. Meningococcal isolates from 10 Active Bacterial Core surveillance sites from 2000 through 2005 were analyzed to identify changes occurring after MCV4 licensure. Isolates were characterized by multilocus sequence typing (MLST) and outer membrane protein gene sequencing. Isolates expressing capsular polysaccharide different from that associated with the MLST lineage were considered to demonstrate capsular switching. Results. Among 1160 isolates, the most common genetic lineages were the sequence type (ST)- 23, ST-32, ST-11, and ST-41/44 clonal complexes. Of serogroup B and Y isolates, 8 (1.5%) and 3 (0.9%), respectively, demonstrated capsular switching, compared with 36 (12.9%) for serogroup C (P < .001); most serogroup C switches were from virulent serogroup B and/or serogroup Y lineages. Conclusions. A limited number of genetic lineages caused the majority of invasive meningococcal infections. A substantial proportion of isolates had evidence of capsular switching. The high prevalence of capsular switching requires surveillance to detect changes in the meningococcal population structure that may affect the effectiveness of meningococcal vaccines. C1 [Harrison, Lee H.; Shutt, Kathleen A.; Marsh, Jane W.] Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Div Infect Dis, Pittsburgh, PA 15261 USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Harrison, Lee H.; Shutt, Kathleen A.; Marsh, Jane W.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Schmink, Susanna E.; Harcourt, Brian H.; Wang, Xin; Whitney, Anne M.; Cohn, Amanda A.; Messonnier, Nancy E.; Mayer, Leonard W.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis,Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Stephens, David S.] Emory Univ, Robert W Woodruff Hlth Sci Ctr, Atlanta, GA 30322 USA. [Stephens, David S.] VA Med Ctr, Med Res Serv, Atlanta, GA USA. RP Harrison, LH (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Div Infect Dis, 521 Parran Hall,130 Desoto St, Pittsburgh, PA 15261 USA. EM lharriso@edc.pitt.edu RI Stephens, David/A-8788-2012; OI Shutt, Kathleen/0000-0003-3376-6152 FU Centers for Diseases Control and Prevention; Sanofi Pasteur FX Financial support: Centers for Diseases Control and Prevention; Sanofi Pasteur (grant). NR 47 TC 52 Z9 52 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 15 PY 2010 VL 201 IS 8 BP 1208 EP 1224 DI 10.1086/651505 PG 17 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 568AJ UT WOS:000275493400016 PM 20199241 ER PT J AU Nargessi, D Ou, CY AF Nargessi, Dokhi Ou, Chin-Yih TI MagaZorb: A Simple Tool for Rapid Isolation of Viral Nucleic Acids SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID DRIED BLOOD SPOTS; EXTRACTION METHODS; DNA EXTRACTION; RT-PCR; PROTOCOL; INFANTS AB Effective isolation of nucleic acids from samples containing viral materials is an essential step for accurate diagnosis of viral infections. The necessity of this critical step before analytical identification and diagnosis of viral infections is paramount to screening programs and to identifying and monitoring epidemics and pandemics. With molecular assays rapidly evolving into routine practice, clinical laboratories face several challenges, including presence of small amounts of viral nucleic acids in abundant levels of genomic DNA and total RNA, processing of various sample types, and carry-over of polymerase chain reaction inhibitors, which could significantly affect polymerase chain reaction and microarray results. MagaZorb nucleic acid isolation technology overcomes these challenges and offers a simple and reliable method for isolation of high-quality and high-yield nucleic acids. Although the MagaZorb technology is readily adaptable to automated platforms, it is also well suited to laboratories in remote areas of resource-poor countries, because a simple magnet is the only device required to perform the procedure manually. Performance characteristics and clinical application of the MagaZorb technology are briefly described here. C1 [Ou, Chin-Yih] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nargessi, Dokhi] Cortex Biochem, San Leandro, CA USA. RP Nargessi, D (reprint author), 551 Creedon Circle, Alameda, CA 94502 USA. EM dnargessi@gmail.com NR 12 TC 3 Z9 3 U1 1 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 15 PY 2010 VL 201 SU 1 BP S37 EP S41 DI 10.1086/650391 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 568AK UT WOS:000275493500005 PM 20225944 ER PT J AU Schito, ML D'Souza, MP Owen, SM Busch, MP AF Schito, Marco L. D'Souza, M. Patricia Owen, S. Michele Busch, Michael P. TI Challenges for Rapid Molecular HIV Diagnostics SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; DRIED BLOOD SPOTS; RESOURCE-LIMITED SETTINGS; MEDIATED ISOTHERMAL AMPLIFICATION; OF-CARE DIAGNOSTICS; REVERSE-TRANSCRIPTION; INFECTION; INFANTS; ANTIBODY; ANTIGEN AB The introduction of serological point-of-care assays 10 years ago dramatically changed the way that human immunodeficiency virus (HIV) infection was identified and diagnosed. Testing at the point of care has lead to a dramatic increase in the number of individuals who are screened and, most importantly, receive their HIV test result. As the AIDS epidemic continues to mature and scientific advances in prevention and treatment are evaluated and implemented, there is a need to identify acute (viremic preseroconversion) infections and to discriminate "window phase" infections from those that are serologically positive, especially in resource-limited settings, where the majority of vulnerable populations reside and where the incidence of HIV infection is highest. Rapid testing methods are now at a crossroads. There is opportunity to implement and evaluate the incremental diagnostic usefulness of new test modalities that are based on sophisticated molecular diagnostic technologies and that can be performed in settings where laboratory infrastructure is minimal. The way forward requires sound scientific judgment and an ability to further develop and implement these tests despite a variety of technical, social, and operational hurdles, to declare success. C1 [Schito, Marco L.] NIAID, Henry Jackson Fdn Advancement Mil Med, Div Aids, NIH, Bethesda, MD 20817 USA. [Owen, S. Michele] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Busch, Michael P.] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA. [Busch, Michael P.] Univ Calif San Francisco, Res & Sci Programs, San Francisco, CA 94143 USA. RP Schito, ML (reprint author), NIAID, Henry Jackson Fdn Advancement Mil Med, Div Aids, NIH, 6700 Rockledge Dr, Bethesda, MD 20817 USA. EM schitom@niaid.nih.gov FU National Institutes of Allergy and Infectious Diseases; Department of Health and Human Services [HHSN272200800014C] FX Federal funds from the National Institutes of Allergy and Infectious Diseases, Department of Health and Human Services (contract number HHSN272200800014C). NR 47 TC 19 Z9 20 U1 1 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 15 PY 2010 VL 201 SU 1 BP S1 EP S6 DI 10.1086/650394 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 568AK UT WOS:000275493500001 PM 20225941 ER PT J AU Kelly, J Heboyan, V Rasulnia, B Urquhart, G AF Kelly, J. Heboyan, V. Rasulnia, B. Urquhart, G. TI Progress in Immunization Information Systems-United States, 2008 (Reprinted from MMWR, vol 59, pg 133-135, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Kelly, J.; Heboyan, V.; Rasulnia, B.; Urquhart, G.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Kelly, J (reprint author), CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RI Tao, Youyou/D-2367-2014 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 14 PY 2010 VL 303 IS 14 BP 1361 EP 1362 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 582KX UT WOS:000276597300011 ER PT J AU Lederman, E Warkentien, T Bavaro, M Arnold, J DeRienzo, D Staples, JE Fischer, M Laven, JJ Kosoy, OL Lanciotti, RS AF Lederman, E. Warkentien, T. Bavaro, M. Arnold, J. DeRienzo, D. Staples, J. E. Fischer, M. Laven, J. J. Kosoy, O. L. Lanciotti, R. S. TI Transfusion-Related Transmission of Yellow Fever Vaccine Virus-California, 2009 (Reprinted from MMWR, vol 59, pg 34-37, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Lederman, E.; Warkentien, T.; Bavaro, M.; Arnold, J.; DeRienzo, D.] USN, Stennis Space Ctr, MS 39529 USA. [Staples, J. E.; Fischer, M.; Laven, J. J.; Kosoy, O. L.; Lanciotti, R. S.] CDC, Div Vector Borne Infect Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Lederman, E (reprint author), USN, Stennis Space Ctr, MS 39529 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 14 PY 2010 VL 303 IS 14 BP 1363 EP 1364 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 582KX UT WOS:000276597300012 ER PT J AU van Griensven, F Thienkrua, W Sukwicha, W Wimonsate, W Chaikummao, S Varangrat, A Mock, PA AF van Griensven, Frits Thienkrua, Warunee Sukwicha, Wichuda Wimonsate, Wipas Chaikummao, Supaporn Varangrat, Anchalee Mock, Philip A. TI RSeesexarc fhrequency and sex planning among men who have sex with men in Bangkok, Thailand: implications for pre- and post-exposure prophylaxis against HIV infection SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Article ID UNITED-STATES; PREEXPOSURE PROPHYLAXIS; COST-EFFECTIVENESS; LIMITED KNOWLEDGE; RISK; CHEMOPROPHYLAXIS; SEROCONVERSION; TENOFOVIR; MACAQUES; IMPACT AB Background: Daily HIV antiretroviral pre-exposure prophylaxis (PrEP) is being evaluated in clinical trials among men who have sex with men (MSM). However, daily PrEP may not be congruent with sexual exposure profiles of MSM. Here, we investigate sex frequency and sex planning to identify and inform appropriate PrEP strategies for MSM. Methods: We evaluated sex frequency and sex planning in a cohort of HIV-negative MSM in Bangkok, Thailand. Chi-squared test was used to compare reports of sex on different weekdays; logistic regression was used to identify predictors of sex frequency and sex planning. Results: Of 823 MSM (with a mean age of 28.3 years), 86% reported having sex on two days per week or less, and 65% reported their last sex to have been planned. Sex on the weekend (similar to 30%) was more often reported than sex on weekdays (similar to 23%). In multivariate analysis, use of alcohol, erectile dysfunction drugs, group sex, sex with a foreigner, buying and selling sex, and a history of HIV testing were associated with having sex on three days or more per week. Being aged 22 to 29 years, not identifying as homosexual, having receptive anal intercourse, and not engaging in group sex were associated with unplanned sex. Conclusions: Intermittently dosed PrEP (as opposed to daily) may be a feasible HIV prevention strategy and should be considered for evaluation in clinical trials. Risk factors for sex frequency and sex planning may help to identify those in need for daily PrEP and those who may not be able to take a timely pre-exposure dose. C1 [van Griensven, Frits; Thienkrua, Warunee; Sukwicha, Wichuda; Wimonsate, Wipas; Chaikummao, Supaporn; Varangrat, Anchalee; Mock, Philip A.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [van Griensven, Frits] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP van Griensven, F (reprint author), US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. EM fav1@cdc.gov RI van Griensven, Frits/G-4719-2013 OI van Griensven, Frits/0000-0002-0971-2843 NR 17 TC 23 Z9 23 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD APR 14 PY 2010 VL 13 AR 13 DI 10.1186/1758-2652-13-13 PG 14 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 839BX UT WOS:000296340700001 PM 20398261 ER PT J AU Nguyen, HH Tumpey, TM Park, HJ Byun, YH Tran, LD Nguyen, VD Kilgore, PE Czerkinsky, C Katz, JM Seong, BL Song, JM Kim, YB Do, HT Nguyen, T Nguyen, CV AF Nguyen, Huan H. Tumpey, Terrence M. Park, Hae-Jung Byun, Young-Ho Tran, Linh D. Nguyen, Van D. Kilgore, Paul E. Czerkinsky, Cecil Katz, Jacqueline M. Seong, Baik Lin Song, Jae Min Kim, Young Bong Do, Hoa T. Nguyen, Tung Nguyen, Cam V. TI Prophylactic and Therapeutic Efficacy of Avian Antibodies Against Influenza Virus H5N1 and H1N1 in Mice SO PLOS ONE LA English DT Article ID YOLK ANTIBODIES; CHICKEN ANTIBODIES; EGG-YOLK; MONOCLONAL-ANTIBODY; HELICOBACTER-PYLORI; ISOLATED WORLDWIDE; IMMUNOGLOBULIN-Y; INFECTIONS; RESISTANCE; HUMANS AB Background: Pandemic influenza poses a serious threat to global health and the world economy. While vaccines are currently under development, passive immunization could offer an alternative strategy to prevent and treat influenza virus infection. Attempts to develop monoclonal antibodies (mAbs) have been made. However, passive immunization based on mAbs may require a cocktail of mAbs with broader specificity in order to provide full protection since mAbs are generally specific for single epitopes. Chicken immunoglobulins (IgY) found in egg yolk have been used mainly for treatment of infectious diseases of the gastrointestinal tract. Because the recent epidemic of highly pathogenic avian influenza virus (HPAIV) strain H5N1 has resulted in serious economic losses to the poultry industry, many countries including Vietnam have introduced mass vaccination of poultry with H5N1 virus vaccines. We reasoned that IgY from consumable eggs available in supermarkets in Vietnam could provide protection against infections with HPAIV H5N1. Methods and Findings: We found that H5N1-specific IgY that are prepared from eggs available in supermarkets in Vietnam by a rapid and simple water dilution method cross-protect against infections with HPAIV H5N1 and related H5N2 strains in mice. When administered intranasally before or after lethal infection, the IgY prevent the infection or significantly reduce viral replication resulting in complete recovery from the disease, respectively. We further generated H1N1 virus-specific IgY by immunization of hens with inactivated H1N1 A/PR/8/34 as a model virus for the current pandemic H1N1/09 and found that such H1N1-specific IgY protect mice from lethal influenza virus infection. Conclusions: The findings suggest that readily available H5N1-specific IgY offer an enormous source of valuable biological material to combat a potential H5N1 pandemic. In addition, our study provides a proof-of-concept for the approach using virus-specific IgY as affordable, safe, and effective alternative for the control of influenza outbreaks, including the current H1N1 pandemic. C1 [Nguyen, Huan H.; Park, Hae-Jung; Kilgore, Paul E.; Czerkinsky, Cecil] Int Vaccine Inst, Seoul, South Korea. [Tumpey, Terrence M.; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA. [Byun, Young-Ho; Seong, Baik Lin; Song, Jae Min] Yonsei Univ, Coll Engn, Dept Biotechnol, Seoul 120749, South Korea. [Tran, Linh D.; Nguyen, Van D.; Kim, Young Bong] Konkuk Univ, Coll Anim Biosci & Technol, Dept Anim Biotechnol, Seoul, South Korea. [Do, Hoa T.; Nguyen, Tung; Nguyen, Cam V.] Natl Ctr Vet Diagnost, Dept Anim Hlth, Hanoi, Vietnam. [Nguyen, Huan H.] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA. RP Nguyen, HH (reprint author), Int Vaccine Inst, Seoul, South Korea. EM hhnguyen@ivi.int RI CZERKINSKY, CECIL/G-6520-2015; Kilgore, Paul/L-1462-2013 OI Kilgore, Paul/0000-0003-3214-4482 FU government of the Republic of Korea; government of Sweden; government of the Netherlands; government of Kuwait; Bill & Melinda Gates Foundation; Korean Healthcare Technology [A085105]; Ministry of Health and Welfare Family Affairs, Republic of Korea; Korea Research Council of Fundamental Science Technology [KGM3110912] FX The International Vaccine Institute is supported by the governments of the Republic of Korea, Sweden, the Netherlands, and Kuwait. This work was supported in part by the Bill & Melinda Gates Foundation (to HHN), the Korean Healthcare Technology R&D Project (A085105), the Ministry of Health and Welfare Family Affairs, Republic of Korea (to BLS), and the Top Brand Project grant, Korea Research Council of Fundamental Science & Technology and KRIBB Initiative program (KGM3110912 to YBK). The findings and conclusions in this report are those of the authors and do not necessarily reflect the views of the funding agencies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 24 Z9 27 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 13 PY 2010 VL 5 IS 4 AR e10152 DI 10.1371/journal.pone.0010152 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 583UV UT WOS:000276706300008 PM 20405007 ER PT J AU Duke, V Samiel, S Musa, D Ali, C Chang-Kit, C Warner, C AF Duke, Violet Samiel, Sheila Musa, David Ali, Cameile Chang-Kit, Catherine Warner, Cynthia TI Same-visit HIV testing in Trinidad and Tobago SO BMC PUBLIC HEALTH LA English DT Article ID HIV/AIDS AB Background: The Ministry of Health (hereafter, Ministry) of Trinidad and Tobago is responsible for delivery of all health services in the country. The Ministry takes responsibility for direct delivery of care in the public sector and has initiated a process whereby those seeking HIV test results could obtain confidential reports during a single-visit to a testing location. The Ministry requested technical assistance with this process from the Caribbean Epidemiology Centre (CAREC). The United States Centers for Disease Control and Prevention (CDC) played an important role in this process through its partnership with CAREC. Methods: Under the technical guidance of CAREC and CDC, the Ministry organized a technical working group which included representatives from key national HIV program services and technical assistance partners. This working group reviewed internationally-recognized best practices for HIV rapid testing and proposed a program that could be integrated into the national HIV programs of Trinidad and Tobago. The working group wrote a consensus protocol, defined certification criteria, prepared training materials and oversaw implementation of "same-visit" HIV testing at two pilot sites. Results: A Ministry-of-Health-supported program of "same-visit" HIV testing has been established in Trinidad and Tobago. This program provides confidential testing that is independent of laboratory confirmation. The program allows clients who want to know their HIV status to obtain this information during a single-visit to a testing location. Testers who are certified to provide testing on behalf of the Ministry are also counselors. Non-laboratory personnel have been trained to provide HIV testing in non-laboratory locations. The program includes procedures to assure uniform quality of testing across multiple testing sites. Several procedural and training documents were developed during implementation of this program. This report contains links to those documents. Conclusions: The Ministry of Health has implemented a program of "same-visit" HIV testing in Trinidad and Tobago. This program provides clients confidential HIV test reports during a single visit to a testing location. The program is staffed by non-laboratory personnel who are trained to provide both testing and counseling in decentralized (non-laboratory) settings. This approach may serve as a model for other small countries. C1 [Warner, Cynthia] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Duke, Violet] Minist Hlth, Port Of Spain, Trinid & Tobago. [Samiel, Sheila] Pan Amer Hlth Org, Bridgetown, Barbados. [Musa, David] George St Hlth Ctr, Port Of Spain, Trinid & Tobago. [Ali, Cameile] Petit Valley, Port Of Spain, Trinid & Tobago. [Chang-Kit, Catherine] St Annes, Port Of Spain, Trinid & Tobago. RP Warner, C (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM cynthiakwarner@mac.com NR 10 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD APR 9 PY 2010 VL 10 AR 185 DI 10.1186/1471-2458-10-185 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 589AD UT WOS:000277115200001 PM 20380695 ER PT J AU Duan, S Shen, S Bulterys, M Jia, YJ Yang, YC Xiang, LF Tian, F Lu, L Xiao, Y Wang, MJ Jia, MH Jiang, HZ Vermund, SH Jiang, Y AF Duan, Song Shen, Sheng Bulterys, Marc Jia, Yujiang Yang, Yuecheng Xiang, Lifeng Tian, Fei Lu, Lin Xiao, Yao Wang, Minjie Jia, Manhong Jiang, Huazhou Vermund, Sten H. Jiang, Yan TI Estimation of HIV-1 incidence among five focal populations in Dehong, Yunnan: a hard hit area along a major drug trafficking route SO BMC PUBLIC HEALTH LA English DT Article ID BED-ENZYME-IMMUNOASSAY; FREE ANTIRETROVIRAL TREATMENT; RAPID SCALE-UP; TYPE-1 INCIDENCE; HIV/AIDS EPIDEMIC; RECENT INFECTION; CHINA; SURVEILLANCE; PREVENTION; AFRICA AB Background: Since 1989 when the first 146 HIV positives in China were identified, Dehong Prefecture had been one of the areas hardest-hit by HIV in China. The local and national governments have put substantial financial resources into tackling the HIV epidemic in Dehong from 2004. The objective of this study was to track dynamic changes in HIV-1 prevalence and incidence among five focal populations in Dehong and to assess the impact of HIV prevention and control efforts. Methods: Consecutive cross-sectional surveys conducted in five focal populations between 2004 and 2008. Specimens seropositive for HIV were tested with the BED IgG capture enzyme immunoassay to identify recent seroconversions (median, 155 days) using normalized optical density of 0.8 and adjustments. Results: From 2004 to 2008, estimated annual HIV incidence among injecting drug users (IDUs) decreased significantly [from 15.0% (95% CI = 11.4%-18.5%) in 2004 to 4.3% (95% CI = 2.4%-6.2%) in 2008; trend test P < 0.0001]. The incidence among other focal populations, such as HIV discordant couples (varying from 5.5% to 4.7%), female sex workers (varying from 1.4% to 1.3%), pregnant women (0.1%), and pre-marital couples (0.2 to 0.1%) remained stable. Overall, the proportion of recent HIV-1 infections was higher among females than males (P < 0.0001). Conclusions: The HIV epidemic in Dehong continued to expand during a five-year period but at a slowing rate among IDUs, and HIV incidence remains high among IDUs and discordant couples. Intensive prevention measures should target sub-groups at highest risk to further slow the epidemic and control the migration of HIV to other areas of China, and multivariate analysis is needed to explore which measures are more effective for different populations. C1 [Jia, Yujiang; Vermund, Sten H.] Vanderbilt Univ Sch Med, Amos Christie Chair Global Hlth, Inst Global Hlth, Nashville, TN 37203 USA. [Shen, Sheng; Tian, Fei; Xiao, Yao; Wang, Minjie; Jiang, Huazhou; Jiang, Yan] Chinese Ctr Dis Control & Prevent, Natl AIDS Reference Lab, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China. [Duan, Song; Yang, Yuecheng; Xiang, Lifeng] Dehong Dai & Jingpo Nationality Autonomous Prefec, Dept HIV AIDS Control & Prevent, Dehong, Yunnan, Peoples R China. [Bulterys, Marc] US Ctr Dis Control & Prevent, Global AIDS Program China, Atlanta, GA USA. [Lu, Lin; Jia, Manhong] Yunnan Prov Ctr Dis Control & Prevent, Dept HIV AIDS Control & Prevent, Kunming, Yunnan, Peoples R China. RP Vermund, SH (reprint author), Vanderbilt Univ Sch Med, Amos Christie Chair Global Hlth, Inst Global Hlth, Nashville, TN 37203 USA. EM sten.vermund@vanderbilt.edu; jiangyan03@263.net OI Vermund, Sten/0000-0001-7289-8698 FU National Center for AIDS/STD Control and Prevention, China CDC [2008ZX10001-003]; Dehong Prefecture Center for Disease Control and Prevention; Yunnan Center for Disease Control and Prevention [2004BA719A14-1]; National Institutes of Health [1R03AI073134, D43 TW001035]; US CDC Global AIDS Program in China; Vanderbilt University School of Medicine Institute for Global Health FX The authors would like to thank Dr. Ruiguang Song, Dr. Andrea A. Kim, Dr. Shuo Wang and Chunmei Li for statistical support in BED data analysis. The laboratory of Dr. Bharat Parekh provided quality assurance and technical guidance for BED testing. Chris Korhonen and Chin-Yih Ou provided helpful feedback on an earlier version of the paper. The views expressed in this article are those of the authors and do not necessarily reflect the official position of the US Centers for Disease Control and Prevention. Sponsorship: This study was supported, in part, by the National Center for AIDS/STD Control and Prevention, China CDC ("Eleventh Five-Year Plan" of the National Key Science & Technology Program, Grant # 2008ZX10001-003), the Dehong Prefecture Center for Disease Control and Prevention, the Yunnan Center for Disease Control and Prevention (The Tenth Five-year of Key Technologies R & D Program, Grant # 2004BA719A14-1), the National Institutes of Health (Grant # 1R03AI073134 and Grant # D43 TW001035), the US CDC Global AIDS Program in China, and the Vanderbilt University School of Medicine Institute for Global Health. NR 36 TC 25 Z9 32 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD APR 7 PY 2010 VL 10 AR 180 DI 10.1186/1471-2458-10-180 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 589AA UT WOS:000277114900001 PM 20374618 ER PT J AU Lampe, MA Nesheim, S Shouse, RL Borkowf, CB Minasandram, V Little, K Kilmarx, PH Whitmore, S Taylor, A Valleroy, L AF Lampe, M. A. Nesheim, S. Shouse, R. L. Borkowf, C. B. Minasandram, V. Little, K. Kilmarx, P. H. Whitmore, S. Taylor, A. Valleroy, L. TI Racial/Ethnic Disparities Among Children With Diagnoses of Perinatal HIV Infection-34 States, 2004-2007 (Reprinted from MMWR, vol 59, pg 97-101, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID UNITED-STATES; TRANSMISSION C1 [Lampe, M. A.; Nesheim, S.; Shouse, R. L.; Borkowf, C. B.; Minasandram, V.; Little, K.; Kilmarx, P. H.; Whitmore, S.; Taylor, A.; Valleroy, L.] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Lampe, MA (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 7 PY 2010 VL 303 IS 13 BP 1246 EP 1248 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 579FM UT WOS:000276353700011 ER PT J AU Parsonage, D Desrosiers, DC Hazlett, KRO Sun, YC Nelson, KJ Cox, DL Radolf, JD Poole, LB AF Parsonage, Derek Desrosiers, Daniel C. Hazlett, Karsten R. O. Sun, Yongcheng Nelson, Kimberly J. Cox, David L. Radolf, Justin D. Poole, Leslie B. TI Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE alkyl hydroperoxide reductase; peroxidases; syphilis; syphilis spirochete; oxidative stress ID REDOX-SENSITIVE OLIGOMERIZATION; ALKYL HYDROPEROXIDE REDUCTASE; ESCHERICHIA-COLI THIOREDOXIN; A-DISULFIDE REDUCTASE; HYDROGEN-PEROXIDE; SYPHILIS SPIROCHETE; CRYSTAL-STRUCTURE; BACTERIAL PEROXIREDOXIN; SUPEROXIDE REDUCTASE; BORRELIA-BURGDORFERI AB Little is known about the mechanisms by which Treponema pallidum (Tp), the causative agent of syphilis, copes with oxidative stress as it establishes persistent infection within its obligate human host. The Tp genomic sequence indicates that the bacterium's antioxidant defenses do not include glutathione and are limited to just a few proteins, with only one, TP0509, offering direct defense against peroxides. Although this Tp peroxiredoxin (Prx) closely resembles AhpC-like Prxs, Tp lacks AhpF, the typical reductant for such enzymes. Functionally, TpAhpC resembles largely eukaryotic, nonAhpC typical 2-Cys Prx proteins in using thioredoxin (Trx, TP0919) as an efficient electron donor and exhibiting broad specificity toward hydroperoxide substrates. Unlike many of the eukaryotic Prxs, however, TpAhpC is relatively resistant to inactivation during turnover with hydroperoxide substrates. As is often observed in typical 2-Cys Prxs, TpAhpC undergoes redox-sensitive oligomer formation. Quantitative immunoblotting revealed that TpTrx and TpAhpC are present at very high levels (over 100 and 300 mu M, respectively) in treponemes infecting rabbit testes; their redox potentials, at -242 +/- 1 and -192 +/- 2 mV, respectively, are consistent with the role of TpTrx as the cellular reductant of TpAhpC. Transcriptional analysis of select antioxidant genes confirmed the presence of high mRNA levels for ahpC and trx which diminish greatly when spirochetes replicate under in vitro growth conditions. Thus, T. pallidum has evolved an extraordinarily robust, broad-spectrum AhpC as its sole mechanism for peroxide defense to combat this significant threat to treponemal growth and survival during infection. C1 [Parsonage, Derek; Nelson, Kimberly J.; Poole, Leslie B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA. [Desrosiers, Daniel C.; Hazlett, Karsten R. O.; Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA. [Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA. [Sun, Yongcheng; Cox, David L.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Poole, LB (reprint author), Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA. EM lbpoole@wfubmc.edu FU National Institutes of Health [R01 GM050389, R01 AI026756] FX The authors thank Samantha Alley for contributing experimental data. This work was supported by National Institutes of Health Grant R01 GM050389 (to L. B. P) and Grant R01 AI026756 (to J. D. R.). NR 52 TC 24 Z9 24 U1 0 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 6 PY 2010 VL 107 IS 14 BP 6240 EP 6245 DI 10.1073/pnas.0910057107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 579MH UT WOS:000276374400023 PM 20304799 ER PT J AU DeStefano, F Tokars, J AF DeStefano, Frank Tokars, Jerome TI H1N1 vaccine safety monitoring: beyond background rates SO LANCET LA English DT Editorial Material C1 [DeStefano, Frank; Tokars, Jerome] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA. RP DeStefano, F (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA. EM fdestefano@cdc.gov NR 5 TC 10 Z9 11 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD APR 3 PY 2010 VL 375 IS 9721 BP 1146 EP 1147 DI 10.1016/S0140-6736(09)61917-6 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 585VL UT WOS:000276858200009 PM 19880171 ER PT J AU Odhiambo, FO Hamel, MJ Williamson, J Lindblade, K ter Kuile, FO Peterson, E Otieno, P Kariuki, S Vulule, J Slutsker, L Newman, RD AF Odhiambo, Frank O. Hamel, Mary J. Williamson, John Lindblade, Kim ter Kuile, Feiko O. Peterson, Elizabeth Otieno, Peter Kariuki, Simon Vulule, John Slutsker, Laurence Newman, Robert D. TI Intermittent Preventive Treatment in Infants for the Prevention of Malaria in Rural Western Kenya: A Randomized, Double-Blind Placebo-Controlled Trial SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; PLUS SULFADOXINE-PYRIMETHAMINE; TREATED BED NETS; UNCOMPLICATED MALARIA; CHLORPROGUANIL-DAPSONE; AFRICAN CHILDREN; AMODIAQUINE-ARTESUNATE; ANTIMALARIAL TREATMENT; ROUTINE VACCINATIONS; TANZANIAN CHILDREN AB Background: Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) for the prevention of malaria has shown promising results in six trials. However, resistance to SP is rising and alternative drug combinations need to be evaluated to better understand the role of treatment versus prophylactic effects. Methods: Between March 2004 and March 2008, in an area of western Kenya with year round malaria transmission with high seasonal intensity and high usage of insecticide-treated nets, we conducted a randomized, double-blind placebo-controlled trial with SP plus 3 days of artesunate (SP-AS3), 3 days of amodiaquine-artesunate (AQ3-AS3), or 3 days of short-acting chlorproguanil-dapsone (CD3) administered at routine expanded programme of immunization visits (10 weeks, 14 weeks and 9 months). Principal Findings: 1,365 subjects were included in the analysis. The incidence of first or only episode of clinical malaria during the first year of life (primary endpoint) was 0.98 episodes/person-year in the placebo group, 0.74 in the SP-AS3 group, 0.76 in the AQ3-AS3 group, and 0.82 in the CD3 group. The protective efficacy (PE) and 95% confidence intervals against the primary endpoint were: 25.7% (6.3, 41.1); 25.9% (6.8, 41.0); and 16.3% (-5.2, 33.5) in the SP-AS3, AQ3-AS3, and CD3 groups, respectively. The PEs for moderate-to-severe anaemia were: 27.5% (-6.9, 50.8); 23.1% (-11.9, 47.2); and 11.4% (-28.6, 39.0). The duration of the protective effect remained significant for up to 5 to 8 weeks for SP-AS3 and AQ3-AS3. There was no evidence for a sustained beneficial or rebound effect in the second year of life. All regimens were well tolerated. Conclusions: These results support the view that IPTi with long-acting regimens provide protection against clinical malaria for up to 8 weeks even in the presence of high ITN coverage, and that the prophylactic rather than the treatment effect of IPTi appears central to its protective efficacy. C1 [Odhiambo, Frank O.; Hamel, Mary J.; Otieno, Peter; Kariuki, Simon; Vulule, John] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Hamel, Mary J.; Williamson, John; Lindblade, Kim; Slutsker, Laurence; Newman, Robert D.] Ctr Dis Control & Prevent, Div Parasit Dis, Malaria Branch, Atlanta, GA USA. [ter Kuile, Feiko O.] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Peterson, Elizabeth] Vermont Dept Hlth, Burlington, VT 05402 USA. RP Odhiambo, FO (reprint author), Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. EM fodhiambo@ke.cdc.gov OI ter Kuile, Feiko/0000-0003-3663-5617 FU Bill & Melinda Gates Foundation Global Health Program [28578] FX Bill & Melinda Gates Foundation Global Health Program, Grant ID# 28578. http://www.gatesfoundation.org/global-health/Pages/overview.aspx. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 21 Z9 21 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 2 PY 2010 VL 5 IS 3 AR e10016 DI 10.1371/journal.pone.0010016 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 580AW UT WOS:000276419900016 PM 20368815 ER PT J AU Bloch, M Tong, VT Novotny, TE England, LJ Dietz, PM Kim, SY Samet, JM Tolosa, JE AF Bloch, Michele Tong, Van T. Novotny, Thomas E. England, Lucinda J. Dietz, Patricia M. Kim, Shin Y. Samet, Jonathan M. Tolosa, Jorge E. TI Tobacco use and secondhand smoke exposure among pregnant women in low- and middle-income countries: a call to action SO ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA LA English DT Editorial Material DE Pregnancy; women's health issues in developing countries; health care policy; maternal mortality and morbidity; preterm birth; tobacco C1 [Tolosa, Jorge E.] Oregon Hlth & Sci Univ, Div Maternal Fetal Med, Global Network Perinatal & Reprod Hlth, Portland, OR 97239 USA. [Tolosa, Jorge E.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97239 USA. [Bloch, Michele] NCI, Bethesda, MD 20892 USA. [Tong, Van T.; England, Lucinda J.; Dietz, Patricia M.; Kim, Shin Y.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Novotny, Thomas E.] San Diego State Univ, San Diego, CA 92182 USA. [Samet, Jonathan M.] Univ So Calif, Inst Global Hlth, Los Angeles, CA USA. RP Tolosa, JE (reprint author), Oregon Hlth & Sci Univ, Div Maternal Fetal Med, Global Network Perinatal & Reprod Hlth, 3181 SW Sam Jackson Pk Rd,L-458, Portland, OR 97239 USA. EM tolosaj@ohsu.edu OI Tong, Van/0000-0002-3970-1440 NR 9 TC 7 Z9 8 U1 0 U2 1 PU TAYLOR & FRANCIS AS PI OSLO PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY SN 0001-6349 J9 ACTA OBSTET GYN SCAN JI Acta Obstet. Gynecol. Scand. PD APR PY 2010 VL 89 IS 4 BP 418 EP 422 DI 10.3109/00016341003605735 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 588SR UT WOS:000277094700003 PM 20367426 ER PT J AU Oncken, CA Dietz, PM Tong, VT Belizan, JM Tolosa, JE Berghella, V Goldenberg, RL Lando, HA Samet, JM Bloch, MH AF Oncken, Cheryl A. Dietz, Patricia M. Tong, Van T. Belizan, Jose M. Tolosa, Jorge E. Berghella, Vincenzo Goldenberg, Robert L. Lando, Harry A. Samet, Jonathan M. Bloch, Michele H. TI Prenatal tobacco prevention and cessation interventions for women in low- and middle-income countries SO ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA LA English DT Review DE Global; tobacco; perinatal and reproductive health ID RANDOMIZED CONTROLLED-TRIAL; NICOTINE REPLACEMENT THERAPY; CIGARETTE WARNING LABELS; SMOKING-CESSATION; PREGNANT-WOMEN; SMOKELESS TOBACCO; INCREASED RISK; CHILD MALNUTRITION; PATERNAL SMOKING; SECONDHAND SMOKE AB Although the prevalence of tobacco use is decreasing in many high-income countries, it is increasing in many low- and middle-income countries. The health and economic burden of increasing tobacco use and dependence is predictable and will have devastating effects in countries with limited resources, particularly for vulnerable populations such as pregnant women. We sought to review effective tobacco prevention and intervention strategies for decreasing tobacco use and secondhand smoke exposure before and during pregnancy in high-, middle-, and low- income countries. We reviewed several types of interventions, including population-level efforts ( increasing tobacco prices, implementing tobacco control policies), community interventions, clinical interventions, and pharmacological treatments. A second purpose of this report is to present findings of an international expert working group that was convened to review the evidence and to establish research priorities in the following areas: ( a) preventing the uptake and reducing tobacco use among girls and women of reproductive age; and (b) reducing tobacco use and secondhand smoke exposure among pregnant women. The working group considered the evidence on existing interventions in terms of burden of disease, intervention impact, intervention costs, feasibility of integration into existing services, uniqueness of the contribution, and overall feasibility. Finally, we present the working group's recommendations for intervention research priorities. C1 [Oncken, Cheryl A.] Univ Connecticut, Sch Med, Dept Med, Farmington, CT 06030 USA. [Oncken, Cheryl A.] Univ Connecticut, Sch Med, Dept Obstet & Gynecol, Farmington, CT 06030 USA. [Dietz, Patricia M.; Tong, Van T.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Belizan, Jose M.] Inst Clin Effectiveness & Hlth Policy, Dept Mother & Child Hlth Res, Buenos Aires, DF, Argentina. [Tolosa, Jorge E.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA. [Tolosa, Jorge E.; Berghella, Vincenzo] Global Network Perinatal & Reprod Hlth, Portland, OR USA. [Berghella, Vincenzo] Thomas Jefferson Univ, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA. [Goldenberg, Robert L.] Drexel Univ, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA. [Lando, Harry A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Bloch, Michele H.] NCI, Tobacco Control Res Branch, Bethesda, MD 20892 USA. RP Oncken, CA (reprint author), Univ Connecticut, Sch Med, Dept Med, MC 3940,263 Farmington Ave, Farmington, CT 06030 USA. EM oncken@nso2.uchc.edu OI Tong, Van/0000-0002-3970-1440; Belizan, Jose/0000-0002-8412-3010; Berghella, Vincenzo/0000-0003-2854-0239 FU NICHD NIH HHS [U01 HD040607] NR 71 TC 18 Z9 19 U1 3 U2 13 PU TAYLOR & FRANCIS AS PI OSLO PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY SN 0001-6349 J9 ACTA OBSTET GYN SCAN JI Acta Obstet. Gynecol. Scand. PD APR PY 2010 VL 89 IS 4 BP 442 EP 453 DI 10.3109/00016341003678450 PG 12 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 588SR UT WOS:000277094700005 PM 20235895 ER PT J AU England, LJ Kim, SY Tomar, SL Ray, CS Gupta, PC Eissenberg, T Cnattingius, S Bernert, JT Tita, ATN Winn, DM Djordjevic, MV Lambe, M Stamilio, D Chipato, T Tolosa, JE AF England, Lucinda J. Kim, Shin Y. Tomar, Scott L. Ray, Cecily S. Gupta, Prakash C. Eissenberg, Thomas Cnattingius, Sven Bernert, John T. Tita, Alan Thevenet N. Winn, Deborah M. Djordjevic, Mirjana V. Lambe, Mats Stamilio, David Chipato, Tsungai Tolosa, Jorge E. TI Non-cigarette tobacco use among women and adverse pregnancy outcomes SO ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA LA English DT Review DE Global; smokeless; tobacco; waterpipe; pregnancy ID SMOKELESS TOBACCO; BIRTH-WEIGHT; UNIVERSITY-STUDENTS; ALASKA NATIVES; SMOKING; PREVALENCE; WATERPIPE; INDIA; EXPOSURE; RISK AB Although cigarette smoking remains the most prevalent form of tobacco use in girls and in women of reproductive age globally, use of non-cigarette forms of tobacco is prevalent or gaining in popularity in many parts of the world, especially in low- and middle-income countries. Sparse but growing evidence suggests that the use of some non-cigarette tobacco products during pregnancy increases the risk of adverse pregnancy outcomes. In this paper we review the literature on the prevalence of non-cigarette tobacco product use in pregnant women and in women of reproductive age in high-, middle-, and low- income countries and the evidence that maternal use of these products during pregnancy has adverse health effects. In addition, we communicate findings from an international group of perinatal and tobacco experts that was convened to establish research priorities concerning the use of non-cigarette tobacco products during pregnancy. The working group concluded that attempts to develop a public health response to non-cigarette tobacco use in women are hindered by a lack of data on the epidemiology of use in many parts of the world and by our limited understanding of the type and magnitude of the health effects of these products. We highlight research gaps and provide recommendations for a global research agenda. C1 [England, Lucinda J.; Kim, Shin Y.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30030 USA. [Tomar, Scott L.] Univ Florida, Coll Dent, Dept Community Dent & Behav Sci, Gainesville, FL USA. [Ray, Cecily S.; Gupta, Prakash C.] Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India. [Eissenberg, Thomas] Virginia Commonwealth Univ, Dept Psychol, Richmond, VA 23284 USA. [Eissenberg, Thomas] Virginia Commonwealth Univ, Inst Drug & Alcohol Studies, Richmond, VA 23284 USA. [Cnattingius, Sven] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden. [Bernert, John T.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Tita, Alan Thevenet N.] Univ Alabama, Dept Obstet & Gynecol, Ctr Womens Reprod Hlth, Birmingham, AL 35294 USA. [Winn, Deborah M.; Djordjevic, Mirjana V.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Lambe, Mats] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Stamilio, David] St Louis Univ, Sch Med, Washington Univ, Dept Obstet & Gynecol, St Louis, MO USA. [Chipato, Tsungai] Univ Zimbabwe, Coll Hlth Sci, Dept Obstet & Gynecol, Harare, Zimbabwe. [Chipato, Tsungai; Tolosa, Jorge E.] Global Network Perinatal & Reprod Hlth, Portland, OR USA. [Tolosa, Jorge E.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA. RP England, LJ (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-23, Atlanta, GA 30030 USA. EM lbe9@cdc.gov OI Lambe, Mats/0000-0002-4624-3767 NR 51 TC 20 Z9 21 U1 4 U2 9 PU TAYLOR & FRANCIS AS PI OSLO PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY SN 0001-6349 J9 ACTA OBSTET GYN SCAN JI Acta Obstet. Gynecol. Scand. PD APR PY 2010 VL 89 IS 4 BP 454 EP 464 DI 10.3109/00016341003605719 PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 588SR UT WOS:000277094700006 PM 20225987 ER PT J AU Sanchez, T Finlayson, T Murrill, C Guilin, V Dean, L AF Sanchez, Travis Finlayson, Teresa Murrill, Christopher Guilin, Vincent Dean, Laura TI Risk Behaviors and Psychosocial Stressors in the New York City House Ball Community: A Comparison of Men and Transgender Women Who Have Sex with Men SO AIDS AND BEHAVIOR LA English DT Article DE HIV; Behavior; MSM; Gay; Transgender ID HIV RISK; RACIAL DISPARITIES; UNITED-STATES; YOUNG MEN; GAY MEN; HEALTH; PREVALENCE; VICTIMIZATION; PREVENTION; INFECTION AB The New York City House Ball community consists of social networks of racial/ethnic minority gay, lesbian or bisexual men and women, and transgender persons. HIV seroprevalence and interview data were obtained from a sample of community members to identify statistical differences in HIV prevalence, risk behavior, and psychosocial stressors between men who have sex with men (MSM) and transgender women. Of 301 MSM and 60 transgender women, 20% were HIV-infected and 73% were unaware of their infection, but rates did not differ by gender. Risk behavior and stressors were common in both groups, but transgender women were more likely to report exchange sex, stigmatization, and stressful life events. High rates of risk behavior and HIV in this special community warrant relevant HIV testing and prevention services. Transgender women in the community may be at even greater risk for HIV infection due to behaviors compounded by substantial psychosocial stressors. C1 [Sanchez, Travis; Finlayson, Teresa] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Murrill, Christopher] New York City Dept Hlth & Mental Hyg, HIV Epidemiol Program, New York, NY USA. [Guilin, Vincent] Gay Mens Hlth Crisis Inc, New York, NY USA. [Dean, Laura] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. RP Sanchez, T (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,M-S E-46, Atlanta, GA 30333 USA. EM TSanchez@cdc.gov OI sanchez, travis/0000-0003-1133-4762 FU PHS HHS [U62/CCU2606208-11-2] NR 35 TC 17 Z9 17 U1 0 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS behav. PD APR PY 2010 VL 14 IS 2 BP 351 EP 358 DI 10.1007/s10461-009-9610-6 PG 8 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 567EB UT WOS:000275424800013 PM 19763812 ER PT J AU Chemnasiri, T Netwong, T Visarutratana, S Varangrat, A Li, A Phanuphak, P Jommaroeng, R Akarasewi, P van Griensven, F AF Chemnasiri, Tareerat Netwong, Taweesak Visarutratana, Surasing Varangrat, Anchalee Li, Andrea Phanuphak, Praphan Jommaroeng, Rapeepun Akarasewi, Pasakorn van Griensven, Frits TI INCONSISTENT CONDOM USE AMONG YOUNG MEN WHO HAVE SEX WITH MEN, MALE SEX WORKERS, AND TRANSGENDERS IN THAILAND SO AIDS EDUCATION AND PREVENTION LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; HIV-INFECTION; DRUG-USE; BEHAVIOR; EPIDEMIC; BANGKOK; IMPACT; RISK AB Young men who have sex with men (MSM) are at risk for HIV infection. We investigated inconsistent condom use among 827 sexually active young MSM (15-24 years), enrolled using venue-day-time sampling in Bangkok, Chiang Mai and Phuket, Thailand. Data was collected using palmtop computer-assisted self-interviewing. Of participants, 33.1% were regular MSM, 37.7% were male sex workers (MSWs) and 29.1% were transgenders (TGs). Of MSM, 46.7%, of MSWs, 34.9% and of TGs, 52.3% reported recent inconsistent condom use. In multivariate analysis, receptive anal intercourse (MSM, MSWs), receptive and insertive anal intercourse, living alone and a history of sexual coercion (MSWs), not carrying a condom when interviewed (MSM, TGs), lower education, worrying about HIV infection and a history of sexually transmitted infections (TGs) were significantly and independently associated with inconsistent condom use. Interventions for young MSM are needed and must consider the distinct risk factors of MSM, MSWs, and TGs. C1 [Chemnasiri, Tareerat] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Minist Publ Hlth, Nonthaburi 11000, Thailand. [Netwong, Taweesak] Patong Hosp, Phuket, Thailand. [Visarutratana, Surasing] Chiang Mai Prov Hlth Off, Chiang Mai, Thailand. [Li, Andrea] Vanderbilt Univ Sch Med, Nashville, TN USA. [Phanuphak, Praphan; Jommaroeng, Rapeepun] Thai Red Cross Soc, Bangkok, Thailand. [Jommaroeng, Rapeepun] Rainbow Sky Assoc Thailand, Bangkok, Thailand. [van Griensven, Frits] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Chemnasiri, T (reprint author), US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Minist Publ Hlth, DDC 7 Bldg,4th Floor,Tivanon Rd, Nonthaburi 11000, Thailand. EM tareeratc@th.cdc.gov RI van Griensven, Frits/G-4719-2013 OI van Griensven, Frits/0000-0002-0971-2843 NR 29 TC 38 Z9 39 U1 0 U2 7 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD APR PY 2010 VL 22 IS 2 BP 100 EP 109 PG 10 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 582FD UT WOS:000276580800002 PM 20387981 ER PT J AU Uhrig, JD Bann, CM Wasserman, J Guenther-Grey, C Eroglu, D AF Uhrig, Jennifer D. Bann, Carla M. Wasserman, Jill Guenther-Grey, Carolyn Eroglu, Dogan TI AUDIENCE REACTIONS AND RECEPTIVITY TO HIV PREVENTION MESSAGE CONCEPTS FOR PEOPLE LIVING WITH HIV SO AIDS EDUCATION AND PREVENTION LA English DT Article ID SEXUAL RISK BEHAVIOR; UNITED-STATES; INTERVENTIONS; MEN; TRANSMISSION; HIV/AIDS; MEDIA AB This study measured audience reactions and receptivity to five draft HIV prevention messages developed for people living with HIV (HAIM) to inform future HIV message choice and audience targeting decisions. Our premise was that message concepts that receive wide audience appeal constitute a strong starting point for designing future HIV prevention messages, program activities, and health communication and marketing campaigns for PLWH. The majority of participants indicated agreement with evaluative statements that expressed favorable attitudes toward all five of the message concepts we evaluated. Participants gave the lowest approval to the message promoting sero-sorting. Sociodemographic characteristics played less of a role in predicting differences in message perceptions than attitudes, beliefs and sexual behavior. The general appeal for these messages is encouraging given that messages were expressed in plain text without the support of other creative elements that are commonly used in message execution. These results confirm the utility of systematic efforts to generate and screen message concepts prior to large-scale testing. C1 [Uhrig, Jennifer D.; Bann, Carla M.] International, Res Triangle Pk, NC USA. [Wasserman, Jill; Guenther-Grey, Carolyn; Eroglu, Dogan] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Uhrig, JD (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM uhrig@rti.org FU PHS HHS [200-2001-00123] NR 32 TC 4 Z9 4 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD APR PY 2010 VL 22 IS 2 BP 110 EP 125 PG 16 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 582FD UT WOS:000276580800003 PM 20387982 ER PT J AU Flegal, KM Ogden, CL Yanovski, JA Freedman, DS Shepherd, JA Graubard, BI Borrud, LG AF Flegal, Katherine M. Ogden, Cynthia L. Yanovski, Jack A. Freedman, David S. Shepherd, John A. Graubard, Barry I. Borrud, Lori G. TI High adiposity and high body mass index-for-age in US children and adolescents overall and by race-ethnic group SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID CHILDHOOD OBESITY; PRIMARY-CARE; OVERWEIGHT; PEDIATRICIANS; FATNESS; FAT; DISEASE; GIRLS; YOUNG AB Background: Body mass index (BMI)-for-age has been recommended as a screening test for excess adiposity in children and adolescents. Objective: We quantified the performance of standard categories of BMI-for-age relative to the population prevalence of high adiposity in children and adolescents overall and by race-ethnic group in a nationally representative US population sample by using definitions of high adiposity that are consistent with expert committee recommendations. Design: Percentage body fat in 8821 children and adolescents aged 8-19 y was measured by using dual-energy X-ray absorptiometry in 1999-2004 as part of a health examination survey. Results: With the use of several different cutoffs for percentage fat to define high adiposity, most children with high BMI-for-age (>= 95th percentile of the growth charts) had high adiposity, and few children with normal BMI-for-age (<85th percentile) had high adiposity. The prevalence of high adiposity in intermediate BMI categories varied from 45% to 15% depending on the cutoff. The prevalence of a high BMI was significantly higher in non-Hispanic black girls than in non-Hispanic white girls, but the prevalence of high adiposity was not significantly different. Conclusions: Current BMI cutoffs can identify a high prevalence of high adiposity in children with high BMI-for-age and a low prevalence of high adiposity in children with normal BMI-for-age. By these adiposity measures, less than one-half of children with intermediate BMIs-for-age (85th to <95th percentile) have high adiposity. Differences in high BMI ranges between race-ethnic groups do not necessarily indicate differences in high adiposity. Am J Clin Nutr 2010; 91: 1020-6. C1 [Flegal, Katherine M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Yanovski, Jack A.] NICHHD, Bethesda, MD 20892 USA. [Freedman, David S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Shepherd, John A.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA. [Graubard, Barry I.] NCI, Bethesda, MD 20892 USA. RP Flegal, KM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Room 4315,3311 Toledo Rd, Hyattsville, MD 20782 USA. EM kmf2@cdc.gov RI Flegal, Katherine/A-4608-2013; OI Yanovski, Jack/0000-0001-8542-1637; Flegal, Katherine/0000-0002-0838-469X NR 34 TC 99 Z9 100 U1 0 U2 10 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 2010 VL 91 IS 4 BP 1020 EP 1026 DI 10.3945/ajcn.2009.28589 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 572BV UT WOS:000275802400024 PM 20164313 ER PT J AU Cole, CR Grant, FK Swaby-Ellis, ED Smith, JL Jacques, A Northrop-Clewes, CA Caldwell, KL Pfeiffer, CM Ziegler, TR AF Cole, Conrad R. Grant, Frederick K. Swaby-Ellis, E. Dawn Smith, Joy L. Jacques, Anne Northrop-Clewes, Christine A. Caldwell, Kathleen L. Pfeiffer, Christine M. Ziegler, Thomas R. TI Zinc and iron deficiency and their interrelations in low-income African American and Hispanic children in Atlanta SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID DEVELOPING-COUNTRIES; MICRONUTRIENT DEFICIENCIES; UNITED-STATES; VITAMIN-A; ANEMIA; SERUM; GROWTH; WOMEN; EPIDEMIOLOGY; POPULATION AB Background: Information about the zinc status of low-income minority children in the United States is lacking. Objective: The objective was to determine the prevalence of zinc deficiency and anemia and their interrelation among low-income African American and Hispanic preschool children. Design: This was a cross-sectional study in which a prospective 3-d food diary was completed, and hemoglobin, serum ferritin, zinc, copper, and C-reactive protein concentrations were measured. Children with elevated C-reactive protein concentrations were excluded from analysis. Results: Of 292 children recruited, 280 (mean +/- SD age: 2.5 +/- 1.2 y) qualified for analysis. One hundred forty-six (52%) children were African American and 134 (48%) were Hispanic; 202 (72%) were enrolled in the Women, Infants, and Children nutrition program. A low serum zinc concentration (<10.7 mu mol/L) was present in 34 (12%) children, and 37 (13%) were anemic (hemoglobin, 110 g/L). African American (odds ratio: 3.47; 95% CI: 1.51, 7.96) and anemic (odds ratio: 2.92; 95% CI: 1.24, 6.90) children had an increased risk of zinc deficiency. Serum zinc correlated with hemoglobin (r = 0.24, P < 0.001). Children with a height/length less than the fifth percentile had significantly lower mean serum zinc concentrations than those with a height/length greater than the fifth percentile (12.4 +/- 1.8 compared with 13.0 +/- 2.2 mu mol/L; P, 0.001). In a multiple logistic regression model, African American race-ethnicity was associated with zinc deficiency (odds ratio: 0.26; P = 0.02). The main sources of iron and zinc in the diets were meat products and cereals. Conclusions: The prevalence of zinc deficiency and anemia was high in this population of low-income minority children, especially among African Americans. Further investigation of the incidence of zinc deficiency and the ability of anemia to screen for it is warranted. Am J Clin Nutr 2010; 91: 1027-34. C1 [Cole, Conrad R.] Emory Univ, Sch Med, Div Pediat Gastroenterol Hepatol & Nutr, Dept Pediat, Atlanta, GA 30322 USA. [Cole, Conrad R.; Ziegler, Thomas R.] Emory Univ, Ctr Clin & Mol Nutr, Atlanta, GA 30322 USA. [Ziegler, Thomas R.] Emory Univ, Dept Med, Atlanta, GA 30322 USA. [Cole, Conrad R.; Grant, Frederick K.; Ziegler, Thomas R.] Emory Univ, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA. [Swaby-Ellis, E. Dawn] Grady Mem Hosp, Dept Community Med, Atlanta, GA USA. [Northrop-Clewes, Christine A.; Caldwell, Kathleen L.; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Cole, CR (reprint author), Emory Univ, Sch Med, Div Pediat Gastroenterol Hepatol & Nutr, Dept Pediat, 2015 Uppergate Dr, Atlanta, GA 30322 USA. EM crcole@emory.edu FU Centers for Disease Control and Prevention/Robert W Woodruff Foundation; National Institutes of Health [M01 RR00039/UL1 RR025008, K12 RR017643/KL2 RR025009, K24 RR023356] FX Supported in part by a Centers for Disease Control and Prevention/Robert W Woodruff Foundation Young Investigator in Public Health grant (to CRC) and National Institutes of Health grants M01 RR00039/UL1 RR025008 (Atlanta Clinical and Translational Science Institute), K12 RR017643/KL2 RR025009 (to CRC), and K24 RR023356 (to TRZ). NR 45 TC 33 Z9 33 U1 0 U2 8 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 2010 VL 91 IS 4 BP 1027 EP 1034 DI 10.3945/ajcn.2009.28089 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 572BV UT WOS:000275802400025 PM 20147474 ER PT J AU Morgan, EA Henrich, TJ Jarell, AD Shieh, WJ Zaki, SR Marty, FM Thorner, AR Milner, DA Velazquez, EF AF Morgan, Elizabeth A. Henrich, Timothy J. Jarell, Abel D. Shieh, Wun-Ju Zaki, Sherif R. Marty, Francisco M. Thorner, Anna R. Milner, Dan A. Velazquez, Elsa F. TI Infectious Granulomatous Dermatitis Associated With Rothia mucilaginosa Bacteremia: A Case Report SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE Rothia mucilaginosa; Stomatococcus mucilaginosus; neutropenia; dermatitis; granulomatous ID STOMATOCOCCUS-MUCILAGINOSUS; NEUTROPENIC PATIENTS; SP-NOV; PATIENT; SEPTICEMIA; CANCER; LEUKEMIA; ENDOCARDITIS; MENINGITIS; BLOOD AB Infections with rare pathogens are being recognized with increasing frequency in severely immunocompromised patients. As a result of these patients' underlying compromised defenses and susceptibility to atypical organisms, tissue biopsies from patients within this population may demonstrate nonclassical histopathological findings. Here, we describe an unusual granulomatous reaction to gram-positive cocci in the skin of a 52-year-old man undergoing salvage chemotherapy for acute myeloid leukemia. The patient presented with a papular eruption on the arms, trunk, and face and fever; concomitant blood cultures were positive for Rothia mucilaginosa and Streptococcus salivarius. Histologic evaluation revealed a granulomatous dermatitis associated with numerous small, round, predominantly intracellular bacteria. Classically, cutaneous infiltrates associated with coccoid bacterial infections are suppurative and not granulomatous. The intracellular organisms stained positive for Gram, periodic acid-Schiff, and Grocott methenamine silver stains, suggestive of R. mucilaginosa. Rothia mucilaginosa, a component of the oral flora, was first reported as a human pathogen in 1978. Although the majority of cases in the literature have described R. mucilaginosa bacteremia, other reported manifestations include meningitis, endocarditis, pneumonia, osteomyelitis, and peritonitis. To our knowledge, however, only 1 prior report has described a cutaneous manifestation of R. mucilaginosa septicemia, which occurred in a patient with neutropenia. This is the second reported case of an infectious granulomatous dermatitis associated with R. mucilaginosa bacteremia and raises awareness of this unusual histopathological presentation in the setting of a bacterial infection affecting the skin. C1 [Morgan, Elizabeth A.; Milner, Dan A.; Velazquez, Elsa F.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Henrich, Timothy J.; Marty, Francisco M.; Thorner, Anna R.] Brigham & Womens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA. [Jarell, Abel D.] Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA. [Shieh, Wun-Ju; Zaki, Sherif R.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA. [Marty, Francisco M.; Thorner, Anna R.] Dana Farber Canc Inst, Boston, MA 02115 USA. RP Velazquez, EF (reprint author), Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA. EM efvelazquez@partners.org OI Morgan, Elizabeth/0000-0001-5880-9337 NR 39 TC 10 Z9 10 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD APR PY 2010 VL 32 IS 2 BP 175 EP 179 DI 10.1097/DAD.0b013e3181b1c5ad PG 5 WC Dermatology SC Dermatology GA 581ZM UT WOS:000276564600011 PM 19940746 ER PT J AU Callaghan, WM Dietz, PM AF Callaghan, William M. Dietz, Patricia M. TI Differences in Birth Weight for Gestational Age Distributions According to the Measures Used to Assign Gestational Age SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE fetal development; gestational age; infant; low birth weight ID INTRAUTERINE GROWTH; UNITED-STATES; FETAL-GROWTH; PRETERM DELIVERY; RESTRICTION; RATES; CONSEQUENCES; POPULATION; RECORDS; CURVES AB Population-based standards for infant size for gestational age depend on accurate assessments of birth weight and gestational age; the accuracy of the latter measure has been questioned. The authors sought to explore how different methods of assigning gestational age in vital records data affect distributions of birth weight for gestational age. The 2005 US natality file was used to create 4 measures of gestational age for singleton births consisting of measures found on the 1989 (last menstrual period (LMP) and clinical estimate) and 2003 (LMP and obstetric estimate) revisions of the US standard birth certificate: clinical or obstetric estimate and LMP-based estimate agree within 7 days ("gold standard"); clinical estimate only; obstetric estimate only; and LMP-based estimate only. Birth weight for gestational age distributions differed according to the measurement of gestational age. Regardless of birth certificate revision, the median, 10th, and 90th percentile distributions were virtually identical for the gold standard, clinical estimate, and obstetric estimate. Birth weights for the LMP estimate were higher for preterm births and lower for postterm births for both birth certificate revisions. Agreement between the gold standard estimate and clinical and obstetric estimates of gestational age suggests that using the LMP-based estimate for establishing norms should be revisited. C1 [Callaghan, William M.; Dietz, Patricia M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,MS K-23, Atlanta, GA 30341 USA. EM wgc0@cdc.gov NR 29 TC 40 Z9 40 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD APR 1 PY 2010 VL 171 IS 7 BP 826 EP 836 DI 10.1093/aje/kwp468 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 578IL UT WOS:000276286800009 PM 20185417 ER PT J AU Patel, PR Schaefer, MK Thompson, ND Arduino, MJ AF Patel, Priti R. Schaefer, Melissa K. Thompson, Nicola D. Arduino, Matthew J. TI US INVESTIGATIONS OF HEALTHCARE-RELATED ADVERSE EVENTS IN HEMODIALYSIS PATIENTS, 1999-2009 SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation CY APR 13-17, 2010 CL Orlando, FL SP Natl Kidney Fdn C1 [Patel, Priti R.; Schaefer, Melissa K.; Thompson, Nicola D.; Arduino, Matthew J.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RI Arduino, Matthew/C-1461-2012 OI Arduino, Matthew/0000-0001-7072-538X NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2010 VL 55 IS 4 MA 229 BP A89 EP A89 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 575GH UT WOS:000276054500252 ER PT J AU Callaghan, WM Kuklina, EV Berg, CJ AF Callaghan, William M. Kuklina, Elena V. Berg, Cynthia J. TI Trends in postpartum hemorrhage: United States, 1994-2006 SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE postpartum hemorrhage; pregnancy; uterine atony ID HOSPITAL DISCHARGE DATA; MATERNAL MORBIDITY; BLOOD-LOSS; ACCURACY; DELIVERY; PREGNANCY; DIAGNOSES; LABOR AB OBJECTIVE: The purpose of this study was to estimate the incidence of postpartum hemorrhage (PPH) in the United States and to assess trends. STUDY DESIGN: Population-based data from the 1994-2006 National Inpatient Sample were used to identify women who were hospitalized with postpartum hemorrhage. Data for each year were plotted, and trends were assessed. Multivariable logistic regression was used in an attempt to explain the difference in PPH incidence between 1994 and 2006. RESULTS: PPH increased 26% between 1994 and 2006 from 2.3% (n = 85,954) to 2.9% (n = 124,708; P < .001). The increase primarily was due to an increase in uterine atony, from 1.6% (n = 58,597) to 2.4% (n = 99,904; P < .001). The increase in PPH could not be explained by changes in rates of cesarean delivery, vaginal birth after cesarean delivery, maternal age, multiple birth, hypertension, or diabetes mellitus. CONCLUSION: Population-based surveillance data signal an apparent increase in PPH caused by uterine atony. More nuanced clinical data are needed to understand the factors that are associated with this trend. C1 [Callaghan, William M.; Berg, Cynthia J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Kuklina, Elena V.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy,MS K-23, Atlanta, GA 30341 USA. EM wcallaghan@cdc.gov NR 26 TC 71 Z9 73 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD APR PY 2010 VL 202 IS 4 AR 353.e1 DI 10.1016/j.ajog.2010.01.011 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 575TE UT WOS:000276090400007 PM 20350642 ER PT J AU Moczygemba, CK Paramsothy, P Meikle, S Kourtis, AP Barfield, WD Kuklina, E Posner, SF Whiteman, MK Jamieson, DJ AF Moczygemba, Charmaine K. Paramsothy, Pangaja Meikle, Susan Kourtis, Athena P. Barfield, Wanda D. Kuklina, Elena Posner, Samuel F. Whiteman, Maura K. Jamieson, Denise J. TI Route of delivery and neonatal birth trauma SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT District IV Annual Meeting of the American-College-of-Obstetricians-and-Gynecologists CY SEP 05-07, 2008 CL Orlando, FL SP Amer Coll Obstetricians & Gynecologists DE neonatal birth trauma; patient safety; route of delivery ID CESAREAN DELIVERY; INJURY AB OBJECTIVE: We sought to examine rates of birth trauma in 2 groupings (all International Classification of Diseases, Ninth Revision codes for birth trauma, and as defined by the Agency for Healthcare Research and Quality Patient Safety Indicator [PSI]) among infants born by vaginal and cesarean delivery. STUDY DESIGN: Data on singleton infants were obtained from the 2004-2005 Healthcare Cost and Utilization Project Nationwide Inpatient Sample. RESULTS: The rates of Agency for Healthcare Research and Quality PSI and all birth trauma were 2.45 and 25.85 per 1000 births, respectively. Compared with vaginal, cesarean delivery was associated with increased odds of PSI birth trauma (odds ratio [OR], 1.71), primarily due to an increased risk for "other specified birth trauma" (OR, 2.61). Conversely, cesarean delivery was associated with decreased odds of all birth trauma (OR, 0.55), due to decreased odds of clavicle fractures (OR, 0.07), brachial plexus (OR, 0.10), and scalp injuries (OR, 0.55). CONCLUSION: Infants delivered by cesarean are at risk for different types of birth trauma from infants delivered vaginally. C1 [Moczygemba, Charmaine K.] Emory Univ, Dept Gynecol & Obstet, Emory Sch Med, Atlanta, GA 30303 USA. [Kourtis, Athena P.; Barfield, Wanda D.; Posner, Samuel F.; Whiteman, Maura K.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Kuklina, Elena] Northrop Grumman Civilian Grp, Atlanta, GA USA. [Paramsothy, Pangaja] Contracept Res & Dev Program, Arlington, VA USA. [Meikle, Susan] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Contracept & Reprod Hlth Branch, NIH, Bethesda, MD USA. RP Moczygemba, CK (reprint author), Emory Univ, Dept Gynecol & Obstet, Emory Sch Med, 69 Jesse Hill Jr Dr,4th Floor, Atlanta, GA 30303 USA. EM cmoczygemba@gmail.com OI Posner, Samuel/0000-0003-1574-585X NR 12 TC 2 Z9 2 U1 1 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD APR PY 2010 VL 202 IS 4 AR 361.e1 DI 10.1016/j.ajog.2009.11.041 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 575TE UT WOS:000276090400011 PM 20079477 ER PT J AU Geiss, LS James, C Gregg, EW Albright, A Williamson, DF Cowie, CC AF Geiss, Linda S. James, Cherie Gregg, Edward W. Albright, Ann Williamson, David F. Cowie, Catherine C. TI Diabetes Risk Reduction Behaviors Among US Adults with Prediabetes SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID IMPAIRED GLUCOSE-TOLERANCE; INCIDENT CARDIOVASCULAR EVENTS; PRIMARY-CARE; PHYSICAL-ACTIVITY; PREVENTION PROGRAM; OBESE-PATIENTS; LIFE-STYLE; MELLITUS; WEIGHT; ADVICE AB Background: Diabetes can be prevented or delayed in high-risk adults through lifestyle modifications, including dietary changes, moderate-intensity exercise, and modest weight loss. However, the extent to which U.S. adults with prediabetes are making lifestyle changes consistent with reducing risk is unknown. Purpose: This study aimed to study lifestyle changes consistent with reducing diabetes risk and factors associated with their adoption among adults with prediabetes Methods: In 2009, data were analyzed from 1402 adults aged years without diabetes who participated in the 2005-2006 National Health and Nutrition Examination Survey and had valid fasting plasma glucose and oral glucose tolerance tests The extent to which adults with prediabetes report that in the past year they tried to control or lose weight, reduced the amount of fat or calories in their diet, or increased physical activity or exercise was estimated and factors associated with the adoption of these behaviors were examined Results: Almost 30% of the U.S. adult population had prediabetes in 2005-2006, but only 7 3% (95% CI=5.596, 92%) were aware they had it. About half of adults with prediabetes reported performing diabetes risk reduction behaviors in the past year, but only about one third of adults with prediabetes had received healthcare provider advice about these behaviors in the past year. In multivariate analyses, provider advice, female gender, and being overweight or obese were positively associated with all three risk reduction behaviors. Conclusions: Adoption of risk reduction behaviors among U.S. adults with prediabetes is suboptimal. Efforts to improve awareness of prediabetes, increase promotion of healthy behaviors, and improve availability of evidence-based lifestyle programs are needed to slow the growth in new cases of diabetes (Am J Prev Med 2010,38(4) 403-409) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Geiss, Linda S.; James, Cherie; Gregg, Edward W.; Albright, Ann; Williamson, David F.] Emory Univ, Rollins Sch Publ Hlth, Div Diabet Translat, Atlanta, GA 30322 USA. [Williamson, David F.] Emory Univ, CDC, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Cowie, Catherine C.] NIDDK, NIH, Bethesda, MD USA. RP Geiss, LS (reprint author), Diabet Div, MS K10,4770 Buford Highway NE, Atlanta, GA 30341 USA. NR 31 TC 71 Z9 71 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 BP 403 EP 409 DI 10.1016/j.amepre.2009.12.029 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AS UT WOS:000276419500008 PM 20307809 ER PT J AU Amendah, DD Mvundura, M Kavanagh, PL Sprinz, PG Grosse, SD AF Amendah, Djesika D. Mvundura, Mercy Kavanagh, Patricia L. Sprinz, Philippa G. Grosse, Scott D. TI Sickle Cell Disease-Related Pediatric Medical Expenditures in the US SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PRIVATELY INSURED POPULATION; HEALTH-CARE EXPENDITURES; CHILDREN; ADULTS; STATE AB Background: Although it is known that people with sickle cell disease (SCD) have relatively high utilization of medical care, most previous estimates of SCD-attributable expenditures have been limited to either inpatient care or single-state data Purpose: To extend known findings by measuring the attributable or incremental expenditures per child with SCD compared to children without this illness and to thereby estimate SCD-attributable expenditures among children in the U.S Methods: MarketScan Medicaid and Commercial Claims databases for 2005 were used to estimate total medical expenditures of children with and without SCD. Expenditures attributable to SCD were calculated as the difference in age-adjusted mean expenditures during 2005 for children with SCD relative to children without SCD in the two databases Results: Children with SCD incurred medical expenditures that were $9369 and $13,469 higher than those of children without SCD enrolled in Medicaid and private insurance, respectively In other words, expenditures of children with SCD were 6 and 11 times those of children without SCD enrolled in Medicaid and private insurance, respectively Conclusions: Using a large, multistate, multipayer patient sample, SCD-attributable medical expenditures in children were conservatively and approximately estimated at $335 million in 2005. (Am J Prey Med 2010;38(4S).S550-S556) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Amendah, Djesika D.; Grosse, Scott D.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Mvundura, Mercy] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Kavanagh, Patricia L.; Sprinz, Philippa G.] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA. Boston Med Ctr, Boston, MA USA. RP Amendah, DD (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. OI Kavanagh, Patricia/0000-0002-3312-1576; Mvundura, Mercy/0000-0002-7711-9558 NR 14 TC 40 Z9 40 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S550 EP S556 DI 10.1016/j.amepre.2010.01.004 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800017 PM 20331957 ER PT J AU Atrash, HK Parker, CS AF Atrash, Hani K. Parker, Christopher S. TI The Public Health Response to Blood Disorders SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Editorial Material ID DEEP-VEIN THROMBOSIS; PULMONARY-EMBOLISM; POSTTHROMBOTIC SYNDROME; VENOUS THROMBOSIS; UNITED-STATES; RISK-FACTORS; PREVALENCE; HEMOPHILIA; PREDICTORS; DISEASE AB Nonmalignant blood disorders meet all criteria for qualifying, as a group, as a very important public health problem with serious morbidities affecting over 1 million Americans every year, not including an additional 8 million individuals suffering from anemia Many of these conditions and the morbidities and mortalities associated with them are, to a large extent, preventable. Further, the changing demographic composition of the American population is sure to increase the number of individuals affected by these conditions Yet, nonmalignant blood disorders have not been recognized as important public health priorities. Immediate action is needed to meet the increasing challenge of blood disorders in public health. We propose a national, comprehensive, organized, coordinated, institutionalized, sustainable public health response to blood disorders based on the three core functions and the ten essential services of public health Immediate action needs to be taken to improve surveillance and monitoring, increase public and provider awareness, increase the use of evidence-based practices, and enhance epidemiologic research on the causes, prevention, and treatment of conditions resulting in adverse outcomes. (Am J Prey Med 2010,38(4S) S451-S455) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Atrash, Hani K.; Parker, Christopher S.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Atrash, HK (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. NR 31 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S451 EP S455 DI 10.1016/j.amepre.2010.01.006 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800002 PM 20331942 ER PT J AU Barfield, WD Barradas, DT Manning, SE Kotelchuck, M Shapiro-Mendoza, CK AF Barfield, Wanda D. Barradas, Danielle T. Manning, Susan E. Kotelchuck, Milton Shapiro-Mendoza, Carrie K. TI Sickle Cell Disease and Pregnancy Outcomes Women of African Descent SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID LOW-BIRTH-WEIGHT; DISPARITIES; EXPERIENCE AB Background: Sickle cell disease (SCD) is a severe hematologic condition that presents unique complications among affected pregnant women Many studies of adverse perinatal outcomes associated with SCD are limited by small samples or fail to consider important risk factors Purpose: This study compared perinatal outcomes among women of African ancestry with and without SCD in a large, population-based sample Methods: Data from the Massachusetts Pregnancy to Early Life Longitudinal (PELL) Data System were analyzed during June-August 2009 to identify in-state deliveries to resident women of African descent. Logistic regression analyses compared perinatal outcomes for deliveries among women with and without SCD, adjusted for maternal age, education, parity, plurality, insurance status, adequacy of prenatal care, smoking during pregnancy, and infant gender. Results: During 1998-2006, there were 116,076 deliveries to 84,561 women; SCD prevalence was 0.6%. Adjusted odds of fetal death among deliveries to women with SCD were 2 2 times those among women without SCD (95% CI=1.2, 4 2) Compared to women without SCD, the odds of preterm delivery, low birth weight, and having babies small for gestational age (SGA) among women with SCD were 1.5 (95% CI=1 2, 1.8), 1.7 (95% CI=1.1, 26), and 1.3 (95% CI=1.0, 1.7), respectively. Sickle cell disease was positively associated with cesarean delivery and inductions Conclusions: Population-based linked data systems are useful for assessing risks of adverse health outcomes among women with specific medical conditions, such as SCD. Women with SCD should seek preconception care to identify and modify risk behaviors and receive counseling regarding potential adverse sequelae associated with pregnancy-related morbidity and preterm delivery (Am J Prev Med 2010,38(4S).S542-S549) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Barfield, Wanda D.; Barradas, Danielle T.; Manning, Susan E.; Shapiro-Mendoza, Carrie K.] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Manning, Susan E.] Massachusetts Dept Hlth, Boston, MA USA. [Kotelchuck, Milton] Boston Univ, Sch Publ Hlth, Boston, MA USA. RP Barfield, WD (reprint author), CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS-K22, Atlanta, GA 30341 USA. FU CDC [200-2007-22782, 200-2006-15969] FX This study was funded by CDC contracts 200-2007-22782 and 200-2006-15969 to Boston University School of Public Health. NR 32 TC 25 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S542 EP S549 DI 10.1016/j.amepre.2009.12.020 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800016 PM 20331956 ER PT J AU Beckman, MG Hooper, WC Critchley, SE Ortel, TL AF Beckman, Michele G. Hooper, W. Craig Critchley, Sara E. Ortel, Thomas L. TI Venous Thromboembolism A Public Health Concern SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID DEEP-VEIN THROMBOSIS; ORAL-CONTRACEPTIVE USERS; FACTOR-V-LEIDEN; PULMONARY-EMBOLISM; INHERITED THROMBOPHILIA; RISK-FACTORS; EPIDEMIOLOGY; POPULATION; PREVENTION; PREGNANCY AB Venous thromboembolism (VTE), defined as deep vein thrombosis, pulmonary embolism, or both, affects an estimated 300,000-600,000 individuals in the U.S. each year, causing considerable morbidity and mortality. It is a disorder that can occur in all races and ethmaties, all age groups, and both genders. With many of the known risk factors-advanced age, immobility, surgery, obesity-Increasing in society, VTE is an important and growing public health problem. Recently, a marked increase has occurred in federal and national efforts to raise awareness and acknowledge the need for VTE prevention. Yet, many basic public health functions-surveillance, research, and awareness are still needed. Learning and understanding more about the burden and causes of VTE, and raising awareness among the public and healthcare providers through a comprehensive public health approach, has enormous potential to prevent and reduce death and morbidity from deep vein thrombosis and pulmonary embolism throughout the U.S (Am J Prey Med 2010,38(4S).S495-S501) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Beckman, Michele G.; Hooper, W. Craig; Critchley, Sara E.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Ortel, Thomas L.] Duke Univ, Med Ctr, Durham, NC USA. RP Beckman, MG (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. FU Eisai; GlaxoSmithKline FX TLO has received research grants from Eisai and GlaxoSmithKline, and consults for Sanofi-Aventis. NR 53 TC 150 Z9 155 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S495 EP S501 DI 10.1016/j.amepre.2009.12.017 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800009 PM 20331949 ER PT J AU Boulet, SL Yanni, EA Creary, MS Olney, RS AF Boulet, Sheree L. Yanni, Emad A. Creary, Melissa S. Olney, Richard S. TI Health Status and Healthcare Use in a National Sample of Children with Sickle Cell Disease SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID DEVELOPMENTAL-DISABILITIES; YOUNG-CHILDREN; NEEDS; RETINOPATHY; INSURANCE; DISORDER; SERVICES; ADEQUACY; DEFICITS; HISTORY AB Background: There is a paucity of population-based data describing health status and use of health services among children with sickle cell disease (SCD) Purpose: This study provides estimates of co-occurring conditions, health impact and utilization, and barriers to care for a national sample of children with SCD. Methods: Data were derived from the 1997-2005 National Health Interview Survey Child Sample Core. The study included 192 children aged 0-17 years with SCD whose race was reported as black or African-American, and 19,335 children without SCD of the same age and race. Parents or other knowledgeable adults reported on medical and developmental conditions, health status, and healthcare use and access. Results: After adjusting for demographic characteristics, black children with SCD had higher odds of frequent severe headaches or migraines, intellectual disabilities, regular use of prescription medication, and fair or poor health status compared with black children without SCD. While healthcare and special education services use were generally higher for black children with SCD than for black children in the general population, those with SCD also had higher odds of reporting delays in accessing health care. Conclusions: The health burden for children with SCD and their families is profound and may be exacerbated by barriers to accessing comprehensive medical care. Additional study of the extent of unmet needs for U S children with SCD is warranted. (Am J Prev Med 2010,38(4S),S528-S535) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Boulet, Sheree L.; Creary, Melissa S.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Olney, Richard S.] CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Yanni, Emad A.] CDC, Div Global Migrat, Atlanta, GA 30333 USA. [Yanni, Emad A.] CDC, Quarantine Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Boulet, SL (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-D02, Atlanta, GA 30333 USA. NR 47 TC 33 Z9 33 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S528 EP S535 DI 10.1016/j.amepre.2010.01.003 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800014 PM 20331954 ER PT J AU Drake, JH Soucie, JM Cutter, SC Forsberg, AD Baker, JR Riske, B AF Drake, John H. Soucie, J. Michael Cutter, Susan C. Forsberg, Ann D. Baker, Judith R. Riske, Brenda TI High School Completion Rates Among Men with Hemophilia SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID CHRONIC HEALTH CONDITIONS; ACADEMIC-ACHIEVEMENT; GENETIC-DISORDERS; CHILDREN; ABSENCE; DISEASE; CARE AB Background: The benefits of a high school diploma are well documented. Studies indicate that people with hemophilia have lower than average academic achievement, particularly if they have >12 bleeding episodes annually Purpose: This study compares the high school graduation rate of men with hemophilia to that of the U.S. population of men. Methods: Data were obtained from the Universal Data Collection Program, a surveillance project conducted by approximately 130 hemophilia treatment centers in the nation Data from 7842 men aged >= 18 years were evaluated to determine high school graduation status and were analyzed by race/ethnicity and severity of hemophilia. These data were collected between 1998 and 2008, and analysis was conducted in 2009. Results: Men with hemophilia A had higher or similar high school graduation rates across all racial/ethnic groups and all levels of hemophilia severity, compared with U S men of the same age. Graduation rates for black and Hispanic men with hemophilia B were higher or similar to rates of U S men, but rates for whites were lower, especially among those with moderate and mild disease However, when graduation rates were controlled for areas where Amish populations reside, differences in graduation rates for whites disappeared. Conclusions: In this study, participants obtained hemophilia care at comprehensive hemophilia treatment centers. This multidisciplinary, family-centered care emphasizes prevention of complications, encourages medically supervised disease management, and facilitates psychosocial development The care aims to maximize the affected child's participation in school. This care approach may partially explain the higher-than-expected high school graduation rates among the study population, which is affected by a rare, chronic, and potentially debilitating disorder (Am J Prey Med 2010,38(4S) S489-S494) (C) 2010 Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Drake, John H.] Univ Texas Hlth Sci Ctr Houston, Gulf States Hemophilia & Thrombophilia Ctr, Houston, TX 77030 USA. [Soucie, J. Michael] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Cutter, Susan C.] Hosp Univ Penn, Penn Comprehens Hemophilia & Thrombosis Ctr, Philadelphia, PA 19104 USA. [Forsberg, Ann D.] Univ Massachusetts, Mem Hosp, New England Hemophilia Ctr, Worcester, MA 01605 USA. [Baker, Judith R.] Univ Calif Los Angeles, Div Pediat Hematol Oncol, Los Angeles, CA USA. [Riske, Brenda] Univ Colorado, Hemophilia & Thrombosis Ctr, Denver, CO 80202 USA. RP Drake, JH (reprint author), Univ Texas Hlth Sci Ctr Houston, Gulf States Hemophilia & Thrombophilia Ctr, 6655 Travis,Suite 400, Houston, TX 77030 USA. NR 15 TC 6 Z9 6 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S489 EP S494 DI 10.1016/j.amepre.2009.12.024 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800008 PM 20331948 ER PT J AU Ebrahim, SH Khoja, TAM Elachola, H Atrash, HK Memish, Z Johnson, A AF Ebrahim, Shahul H. Khoja, Tawfik A. M. Elachola, Habida Atrash, Hani K. Memish, Ziad Johnson, Alison TI Children Who Come and Go The State of Sickle Cell Disease in Resource-Poor Countries SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Editorial Material ID DISORDERS; ANEMIA C1 [Ebrahim, Shahul H.; Atrash, Hani K.; Johnson, Alison] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Khoja, Tawfik A. M.] Hlth Ministers Council Gulf States, Riyadh, Saudi Arabia. [Elachola, Habida] MES Med Coll, Calicut, Kerala, India. RP Ebrahim, SH (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E87, Atlanta, GA 30333 USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S568 EP S570 DI 10.1016/j.amepre.2010.01.007 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800019 PM 20331959 ER PT J AU Ebrahim, SH Kulkarni, R Parker, C Atrash, HK AF Ebrahim, Shahul H. Kulkarni, Roshni Parker, Christopher Atrash, Hani K. TI Blood Disorders Among Women Implications for Preconception Care SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SICKLE-CELL-DISEASE; DIAMOND-BLACKFAN ANEMIA; DEEP-VEIN THROMBOSIS; PULMONARY-EMBOLISM; VENOUS THROMBOEMBOLISM; BLEEDING DISORDERS; UNITED-STATES; RISK-FACTORS; PREGNANCY; THROMBOPHILIA AB The objectives of preconception care for women with blood disorders are to provide women and their partners with information on the implications of blood disorders for pregnancy, reproductive choices; and the management of potential or future pregnancies Advances in hematology have led to improved diagnosis and treatment of blood disorders, thereby contributing to longevity and quality of life for women who are either affected by or are carriers of blood disorders Women with blood disorders pose unique challenges. physiologic events such as pregnancy and menstruation influence the manifestations of blood disorders; blood disorders are a risk factor for adverse pregnancy outcomes; pregnancy imposes the risk of potential genetic transmission of the blood disorder to the offspring;and medications used for treatment of blood disorders pose additional challenges to conception and pregnancy Hence, it is crucial that women of childbearing age with blood disorders be provided proper care for their conditions and be counseled before they become pregnant, in time to prevent complications to mothers and infants related to blood disorders. The purpose of this paper is to provide a brief overview of the current knowledge related to blood disorders in women of reproductive age, the interventions needed to manage these conditions, and the implications of these conditions and their management for the health of women and their infants. (Am J Prey Med 2010,38(4S) S459 S467) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Ebrahim, Shahul H.; Kulkarni, Roshni; Parker, Christopher; Atrash, Hani K.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Ebrahim, SH (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E87, Atlanta, GA 30333 USA. NR 56 TC 4 Z9 4 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S459 EP S467 DI 10.1016/j.amepre.2009.12.018 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800004 PM 20331944 ER PT J AU Grosse, SD Boulet, SL Amendah, DD Oyeku, SO AF Grosse, Scott D. Boulet, Sheree L. Amendah, Djesika D. Oyeku, Suzette O. TI Administrative Data Sets and Health Services Research on Hemoglobinopathies A Review of the Literature SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Review ID SICKLE-CELL-DISEASE; PUBLICLY INSURED CHILDREN; UNITED-STATES; CARE UTILIZATION; VASOOCCLUSIVE CRISES; MANAGED CARE; RISK-FACTORS; COSTS; PREGNANCY; MEDICAID AB Context: Large administrative healthcare data sets are an Important source of data for health services research on sickle cell disease (SCD) and thalassemia. This paper identifies and describes major U.S. healthcare administrative databases and their use in published health services research on hemoglobinopathies Evidence acquisition: Publications that used U S administrative healthcare data sets to assess healthcare use or expenditures were identified through Pub Med searches using key words for SCD and either costs, expenditures, or hospital discharges; no additional articles were identified by using thalassemia as a key word. Additional articles were identified through manual searches of related articles or reference lists. Evidence synthesis: A total of 26 original health services research articles were identified. The types of administrative data used for health services research on hemoglobinopathies Included federal- and state-specific hospital discharge data sets and public and private health insurance claims databases Gaps in recent health services research on hemoglobin disorders included a paucity of research related to thalassemia, few studies of adults with hemoglobinopathies, and few studies focusing on emergency department or outpatient clinic use. Conclusions: Administrative data sets provide a unique means to study healthcare use among people with SCD or thalassemia because of the ability to examine large sample sizes at fairly low cost, resulting in greater generalizability than is the case with clinic-based data. Limitations of administrative data in general include potential misclassification, under-reporting, and lack of sociodemographic information. (Am J Prey Med 2010,38(4S) S557-S567) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Grosse, Scott D.; Boulet, Sheree L.; Amendah, Djesika D.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Oyeku, Suzette O.] Childrens Hosp Montefiore, Div Gen Pediat, Bronx, NY USA. [Oyeku, Suzette O.] Yeshiva Univ, Albert Einstein Coll Med, Bronx, NY USA. RP Grosse, SD (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. NR 38 TC 26 Z9 28 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S557 EP S567 DI 10.1016/j.amepre.2009.12.015 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800018 PM 20331958 ER PT J AU Hooper, WC Miller, CH Key, NS AF Hooper, W. Craig Miller, Connie H. Key, Nigel S. TI Complications Associated with Carrier Status Among People with Blood Disorders A Commentary SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Editorial Material ID SICKLE-CELL TRAIT; PUBLIC-HEALTH; GENETIC TESTS; UNITED-STATES; HEMOPHILIA; CHALLENGES; MANAGEMENT; GENOMICS; WOMEN; CONS C1 [Hooper, W. Craig; Miller, Connie H.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Key, Nigel S.] Univ N Carolina, Chapel Hill, NC USA. RP Hooper, WC (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-D02, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 28 TC 2 Z9 3 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S456 EP S458 DI 10.1016/j.amepre.2010.01.009 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800003 PM 20331943 ER PT J AU Siddiqi, AEA Ebrahim, SH Soucie, JM Parker, CS Atrash, HK AF Siddiqi, Azfar-e-Alam Ebrahim, Shahul H. Soucie, J. Michael Parker, Christopher S. Atrash, Hani K. TI Burden of Disease Resulting from Hemophilia in the US SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID ADJUSTED-LIFE-YEARS; UNITED-STATES; INJURY AB Background: Hemophilia is a hereditary bleeding disorder. Its complications can result in substantial morbidity, but few efforts have been made to quantify the disease burden. Purpose: The objective of this analysis was to estimate the burden of disease due to hemophilia (A and B) in the U S, using disability-adjusted life years (DALY). Methods: The approach taken by the WHO in its Global Burden of Disease study was followed. Assumptions were drawn from published literature, and population estimates from the U S Census Bureau for the Year 2007 were used Estimations of years of life lost resulting from mortality (YLL) and years of life lost resulting from morbidity (YLD) were done separately by gender, 5-year age intervals, and severity of disease (morbidity only) with their sum representing DALYs. Disability weights were derived from the quality-of-life tool EuroQol (EQ-5D) The stability of burden estimates was tested by performing sensitivity analyses, changing one assumption at a time Results: In the U.S. in 2007, hemophilia resulted in 110,095 DALYs, composed of 13,418 YLLs and 96,677 YLDs. Large differences between men/boys (107,346) and women/girls (2749) were observed, given that females are genetic carriers of the disorder and rarely present with disease. Sensitivity analyses revealed a relatively robust estimate with a maximum variation of 4.49%. Conclusions: This first estimate of hemophilia-related DALYs in the U S indicates that control of hemophilia can potentially result in a gain of 1 healthy year of life for every 2700 people in the population (Am J Prey Med 2010,38(4S) S482-S488) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Siddiqi, Azfar-e-Alam; Ebrahim, Shahul H.; Soucie, J. Michael; Parker, Christopher S.; Atrash, Hani K.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Siddiqi, AEA (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. NR 25 TC 16 Z9 17 U1 2 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S482 EP S488 DI 10.1016/j.amepre.2009.12.016 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800007 PM 20331947 ER PT J AU Soucie, JM McAlister, S McClellan, A Oakley, M Su, Y AF Soucie, J. Michael McAlister, Sally McClellan, Ann Oakley, Meredith Su, Ying TI The Universal Data Collection Surveillance System for Rare Bleeding Disorders SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PARVOVIRUS B19; HEMOPHILIA; DISEASE; HEALTH; MALES AB Since 1998, the CDC has coordinated a national public health surveillance project the Universal Data Collection (UDC) program on chronic, rare, inherited bleeding disorders In this program, uniform data are gathered through a network of 130 hemophilia treatment centers (HTCs) throughout the U.S. and its territories. Initially, the program was designed to address two primary goals. (1) establishment of a blood-safety monitoring system among people with bleeding disorders, and (2) collection of a uniform set of clinical outcomes data that could be used to monitor trends in the prevalence of infectious diseases and joint complications among this population To this end, the program has been acquiring useful longitudinal data to monitor complications of bleeding disorders For example, with the establishment of range-of-motion measurements for joints as required data elements, a large database has been developed for studies examining risk factors for joint-disease progression. The UDC program data have been used to provide evidence for a national prevention campaign to promote the need for patients with hemophilia to establish or maintain a healthy weight to help prevent joint disease. Risk factors leading to complications such as joint infection have also been identified The application of geographic information systems technology to UDC program data has helped identify needs for outreach and availability of blood products and sources of care Future analyses of data collected on babies, women, and individuals with rarer bleeding disorders than hemophilia will provide further information, leading to improved public health prevention strategies (Am J Prey Med 2010,38(4S),S475-S481) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Soucie, J. Michael; McAlister, Sally; McClellan, Ann; Oakley, Meredith; Su, Ying] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Soucie, JM (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. EM msoucie@cdc.gov NR 16 TC 36 Z9 36 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S475 EP S481 DI 10.1016/j.amepre.2009.12.023 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800006 PM 20331946 ER PT J AU Trimble, SR Parker, CS Grant, AM Soucie, JM Reyes, N AF Trimble, Sean R. Parker, Christopher S. Grant, Althea M. Soucie, J. Michael Reyes, Nimia TI Assessing Emerging Infectious Threats to Blood Safety for the Blood Disorders Community SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID WEST-NILE-VIRUS; TRANSMITTED BACTERIAL-INFECTION; HUMAN PARVOVIRUS B19; HEPATITIS-A; UNITED-STATES; RHEUMATOID-ARTHRITIS; TRYPANOSOMA-CRUZI; TRANSFUSION; TRANSMISSION; DONORS AB Technologic advances in diagnostic testing, vaccinations, pathogen inactivation, and vigilant donor screening have greatly reduced the risk of transmitting pathogens through blood transfusion Nevertheless, transfusion-related infections and fatalities continue to be reported, and emerging pathogens continue to become an increasing threat to the blood supply This threat is even greater to patients with blood disorders, who are heavily transfused and rely on safe blood products. This article describes some of the emerging and re-emerging transfusion-transmitted pathogens that have increased in incidence in the U S in recent years. Peer-reviewed articles and agency websites were the sources of information The article focuses on the treatment of hereditary blood disorders including hemophilia and thalassemia, and hereditary bone marrow failure A coordinated approach to addressing blood safety and continued development of sensitive diagnostic testing arc necessary to reduce risk in an increasingly globalized society (Am J Prey Med 2010,38(4S) S468-S474) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Trimble, Sean R.; Parker, Christopher S.; Grant, Althea M.; Soucie, J. Michael; Reyes, Nimia] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Trimble, SR (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. NR 52 TC 12 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S468 EP S474 DI 10.1016/j.amepre.2009.12.019 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800005 PM 20331945 ER PT J AU Yusuf, HR Atrash, HK Grosse, SD Parker, CS Grant, AM AF Yusuf, Hussain R. Atrash, Hani K. Grosse, Scott D. Parker, Christopher S. Grant, Althea M. TI Emergency Department Visits Made by Patients with Sickle Cell Disease A Descriptive Study, 1999-2007 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HEALTH-CARE UTILIZATION; UNITED-STATES; CHILDREN; MANAGEMENT; MORTALITY; EXPENDITURES; PATTERNS; CRISES; COSTS AB Background: Patients with sickle cell disease (SCD) often use emergency department services to obtain medical care. Limited information is available about emergency department use among patients with SCD. Purpose: This study assessed characteristics of emergency department visits made nationally by patients with SCD Methods: Data from the National Hospital Ambulatory Medical Care Survey (NHAMCS) for the years 1999-2007 were analyzed. The NHAMCS is a survey of hospital emergency department and. outpatient visits. Emergency department visits by patients with SCD were identified using ICD-9-CM codes, and nationally weighted estimates were calculated. Results: On average, approximately 197,333 emergency department visits were estimated to have occurred each year between 1999 and 2007 with SCD as one of the diagnoses listed The expected source of payment was private insurance for 14%, Medicaid/State Children's Health Insurance Program for 58%, Medicare for 14%, and other/unknown for 15% Approximately 29% of visits resulted in hospital admission, this was 37% among patients aged 0-19 years, and 26% among patients aged years. The episode of care was indicated as a follow-up visit for 23% of the visits Patient-cited reasons for the emergency department visit included chest pain (11%); other pain or unspecified pain (67%); fever/infection (6%); and shortness of breath/breathing problem/cough (5%), among other reasons. Conclusions: Substantial numbers of emergency department visits occur among people with SCD The most common reason for the emergency department visits is pain symptoms. The findings of this study can help to improve health services delivery and utilization among patients with SCD. (Am J Prev Med 2010,38(45) S536-S541) Published by Elsevier Inc on behalf of American Journal of Preventive Medicine C1 [Yusuf, Hussain R.; Atrash, Hani K.; Grosse, Scott D.; Parker, Christopher S.; Grant, Althea M.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Yusuf, HR (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E64, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 24 TC 49 Z9 49 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2010 VL 38 IS 4 SU 4 BP S536 EP S541 DI 10.1016/j.amepre.2010.01.001 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 580AV UT WOS:000276419800015 PM 20331955 ER PT J AU Semaan, S Heckathorn, DD Jarlais, DCD Garfein, RS AF Semaan, Salaam Heckathorn, Douglas D. Jarlais, Don C. Des Garfein, Richard S. TI ETHICAL CONSIDERATIONS IN SURVEYS EMPLOYING RESPONDENT-DRIVEN SAMPLING SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Letter ID DEVELOPING-COUNTRIES C1 [Semaan, Salaam] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Heckathorn, Douglas D.] Cornell Univ, Ithaca, NY USA. [Jarlais, Don C. Des] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA. [Garfein, Richard S.] Univ Calif San Diego, San Diego, CA 92103 USA. RP Semaan, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,E-07, Atlanta, GA 30333 USA. EM ssemaan@cdc.gov FU NINR NIH HHS [1R21NR01961]; PHS HHS [R0103574] NR 11 TC 10 Z9 10 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 2010 VL 100 IS 4 BP 582 EP 583 DI 10.2105/AJPH.2009.184200 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 573TG UT WOS:000275937200001 PM 20167881 ER PT J AU Paneth-Pollak, R Schillinger, JA Borrelli, JM Handel, S Pathela, P Blank, S AF Paneth-Pollak, Rachel Schillinger, Julia A. Borrelli, Jessica M. Handel, Shoshanna Pathela, Preeti Blank, Susan TI Using STD Electronic Medical Record Data to Drive Public Health Program Decisions in New York City SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID INFORMATION-TECHNOLOGY; INFECTIONS; QUALITY; SYSTEMS; SUPPORT; IMPACT; COSTS; CARE AB Electronic medical records can house patient information gathered overtime and at multiple sites, thus they have the potential to increase continuity of care and improve service delivery in a multiclinic system. The New York City Department of Health and Mental Hygiene implemented an electronic medical record system in its 10 sexually transmitted disease clinics during 2004 and 2005. We examine the use of real-time electronic medical record data analyses to evaluate clinical services or program activities and present 3 examples of such analyses that have led to program improvements. Analyses of electronic medical record data have produced changes in clinical practice that in turn have resulted in more effective staff use, increased disease detection, and increased clinic capacity. (Am J Public Health. 2010;100: 586-590. doi: 10.2105/AJPH.2009.175349) C1 [Paneth-Pollak, Rachel; Schillinger, Julia A.; Borrelli, Jessica M.; Pathela, Preeti; Blank, Susan] Bur STD Control, New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schillinger, Julia A.; Blank, Susan] US Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Handel, Shoshanna] Bur Maternal Infant & Reprod Hlth, New York City Dept Hlth & Mental Hyg, New York, NY USA. RP Paneth-Pollak, R (reprint author), Michigan State Univ, Coll Human Med, A234 Life Sci, E Lansing, MI 48824 USA. EM panethpo@msu.edu NR 21 TC 11 Z9 11 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 2010 VL 100 IS 4 BP 586 EP 590 DI 10.2105/AJPH.2009.175349 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 573TG UT WOS:000275937200004 PM 20167884 ER PT J AU Frieden, TR AF Frieden, Thomas R. TI A Framework for Public Health Action: The Health Impact Pyramid SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID NEW-YORK-CITY; UNITED-STATES; SOCIAL DETERMINANTS; MALE CIRCUMCISION; DIETARY-SODIUM; BLOOD-PRESSURE; CARE; INTERVENTIONS; INEQUALITIES; PREVENTION AB A 5-tier pyramid best describes the impact of different types of public health interventions and provides a framework to improve health. At the base of this pyramid, indicating interventions with the greatest potential impact, are efforts to address socioeconomic determinants of health. In ascending order are interventions that change the context to make individuals' default decisions healthy, clinical interventions that require limited contact but confer long-term protection, ongoing direct clinical care, and health education and counseling. Interventions focusing on lower levels of the pyramid tend to be more effective because they reach broader segments of society and require less individual effort. Implementing interventions at each of the levels can achieve the maximum possible sustained public health benefit. (Am J Public Health. 2010;100:590-595. doi:10.2105/AJPH.2009.185652) C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS D-14, Atlanta, GA 30333 USA. EM txf2@cdc.gov NR 59 TC 348 Z9 357 U1 2 U2 51 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 2010 VL 100 IS 4 BP 590 EP 595 DI 10.2105/AJPH.2009.185652 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 573TG UT WOS:000275937200005 PM 20167880 ER PT J AU Huhman, ME Potter, LD Nolin, MJ Piesse, A Judkins, DR Banspach, SW Wong, FL AF Huhman, Marian E. Potter, Lance D. Nolin, Mary Jo Piesse, Andrea Judkins, David R. Banspach, Stephen W. Wong, Faye L. TI The Influence of the VERB Campaign on Children's Physical Activity in 2002 to 2006 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID OUTCOME EVALUATION; MEDIA CAMPAIGN; YOUTH; BEHAVIOR; SCHOOL; ADOLESCENCE; CHILDHOOD; FITNESS; DECLINE; HEALTH AB Objectives. We evaluated physical activity outcomes for children exposed to VERB, a campaign to encourage physical activity in children, across campaign years 2002 to 2006. Methods. We examined the associations between exposure to VERB and (1) physical activity sessions (free time and organized) and (2) psychosocial outcomes (outcome expectations, self-efficacy, and social influences) for 3 nationally representative cohorts of children. Outcomes among adolescents aged 13 to 17 years (cohort 1, baseline) and children aged 9 to 13 years from cohorts 2 and 3 were analyzed for dose-response effects. Propensity scoring was used to control for confounding influences. Results. Awareness of VERB remained high across campaign years. In 2006, reports of children aged 10 to 13 years being active on the day before the survey increased significantly as exposure to the campaign increased. Psychosocial outcomes showed dose-response associations. Effects lessened as children aged out of the campaign target age range (cohort 1, baseline), but dose-response associations persisted in 2006 for outcome expectations and free-time physical activity. Conclusions. VERB positively influenced children's physical activity outcomes. Campaign effects persisted as children grew into their adolescent years. (Am J Public Health. 2010;100:638-645. doi:10.2105/AJPH.2008.142968) C1 [Huhman, Marian E.; Banspach, Stephen W.] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. [Potter, Lance D.; Nolin, Mary Jo; Piesse, Andrea; Judkins, David R.] WESTAT Corp, Rockville, MD 20850 USA. [Wong, Faye L.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Huhman, ME (reprint author), Univ Illinois, Dept Commun, 244 Lincoln Hall,702 S Wright St, Urbana, IL 61801 USA. EM mhuhman@illinois.edu NR 33 TC 35 Z9 35 U1 3 U2 13 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 2010 VL 100 IS 4 BP 638 EP 645 DI 10.2105/AJPH.2008.142968 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 573TG UT WOS:000275937200015 PM 19608963 ER PT J AU Vernon, A AF Vernon, Andrew TI A Trial Involving HIV-Tuberculosis in India The Minute Particulars SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Editorial Material ID TREATMENT OUTCOMES; RESISTANCE C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Vernon, A (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD APR 1 PY 2010 VL 181 IS 7 BP 652 EP 654 DI 10.1164/rccm.200912-1822ED PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 578AR UT WOS:000276266100004 PM 20335382 ER PT J AU Blanton, E Ombeki, S Oluoch, GO Mwaki, A Wannemuehler, K Quick, R AF Blanton, Elizabeth Ombeki, Sam Oluoch, Gordon Otieno Mwaki, Alex Wannemuehler, Kathleen Quick, Rob TI Evaluation of the Role of School Children in the Promotion of Point-of-Use Water Treatment and Handwashing in Schools and Households-Nyanza Province, Western Kenya, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; DRINKING-WATER; DIARRHEA PREVENTION; FLOCCULANT-DISINFECTANT; RURAL GUATEMALA; SAFE WATER; INTERVENTION; KNOWLEDGE; PROGRAM AB We installed drinking water and handwashing stations in 17 rural schools and trained teachers to promote water treatment and hygiene to pupils. We gave schools flocculent-disinfectant powder and hypochlorite solution for water treatment. We conducted a baseline water handling survey of pupils' parents from 17 schools and tested stored water for chlorine. We trained teachers and students about hygiene, installed water stations, and distributed instructional comic books to students. We conducted follow-up surveys and chlorine testing at 3 and 13 months. From baseline to 3-month follow-up, parental awareness of the flocculent-disinfectant increased (49-91%, P < 0.0001), awareness of hypochlorite remained high (93-92%), and household use of flocculent-disinfectant (1-7%, P < 0.0001) and hypochlorite (6-13%, P < 0.0001) increased, and were maintained after 13 months. Pupil absentee rates decreased after implementation by 26%. This school-based program resulted in pupil-to-parent knowledge transfer and significant increases in household water treatment practices that were sustained over 1 year. C1 [Blanton, Elizabeth] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Atlanta, GA 30030 USA. Cooperat Assistance & Relief Everywhere Inc, Kenya, Kisumu, Kenya. RP Blanton, E (reprint author), Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, 1600 Clifton Rd,MS A-38, Atlanta, GA 30030 USA. EM eblanton@cdc.gov FU Procter and Gamble Company FX The Procter and Gamble Company exclusively funded the study but did not contribute to study design, data analysis, or interpretation of results. NR 24 TC 32 Z9 32 U1 0 U2 12 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 664 EP 671 DI 10.4269/ajtmh.2010.09-0422 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700027 PM 20348516 ER PT J AU Forshey, BM Stewart, A Morrison, AC Galvez, H Rocha, C Astete, H Eza, D Chen, HW Chao, CC Montgomery, JM Bentzel, DE Ching, WM Kochel, TJ AF Forshey, Brett M. Stewart, Allison Morrison, Amy C. Galvez, Hugo Rocha, Claudio Astete, Helvio Eza, Dominique Chen, Hua-Wei Chao, Chien-Chung Montgomery, Joel M. Bentzel, David E. Ching, Wei-Mei Kochel, Tadeusz J. TI Epidemiology of Spotted Fever Group and Typhus Group Rickettsial Infection in the Amazon Basin of Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID THAI-MYANMAR BORDER; ENDEMIC AREA; CTENOCEPHALIDES-FELIS; AEDES-AEGYPTI; SAO-PAULO; SOUTHEASTERN BRAZIL; NORTHERN PERU; MINAS-GERAIS; CASE SERIES; PREVALENCE AB A seroprevalence study for IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) Rickettsia among humans and domestic pets was conducted in the city of Iquitos, located in the Amazon basin of Peru. Of 1,195 human sera analyzed, 521 (43.6%) and 123 (10.3%) were positive for SFGR and TGR antibodies, respectively. District of residence and participant age were associated with antibody positivity for both groups, whereas rodent sightings in the home were associated with TGR antibody positivity. Of the 71 canines tested, 42 (59.2%) were positive for SFGR antibodies, and two (2.8%) were positive for TGR antibodies; one active SFGR infection was detected by polymerase chain reaction. An uncharacterized SFGR species was detected in 95.9% (71/74) of Ctenocephalides fells pools collected from domestic pets. These data suggest that rickettsial transmission is widespread in Iquitos. Rickettsia species should be further explored as potential causes of acute febrile illnesses in the region. C1 USN, Med Res Ctr Detachment, Iquitos, Peru. USN, Med Res Ctr Detachment, Lima, Peru. Univ Michigan, Ann Arbor, MI 48109 USA. Univ Calif Davis, Davis, CA 95616 USA. Inst Vet Invest Trop & Altura, Iquitos, Peru. USN, Med Res Ctr, Silver Spring, MD USA. US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Kochel, TJ (reprint author), 3230 Lima Pl, Washington, DC 20521 USA. EM tad.kochel@med.navy.mil RI Valle, Ruben/A-7512-2013; Chen, Hua-Wei/A-8018-2011 FU DIRESA-Loreto; United States Department of Defense Global Emerging Infections Systems Research Program [847705.82000.25GB.B0016] FX We thank Carolina Guevara, Cristhopher Cruz, Vidal Felices. Roger Castillo, and Alfredo Huaman for support in the laboratory. Jonathon Sturgis for technical support in the field, and Rebeca Carrion for coordination of field personnel. We thank Paul Graf for critical reading of the manuscript. We also thank the local health authorities. including DIRESA-Loreto, for their support of this and other ongoing studies.; This study was funded by the United States Department of Defense Global Emerging Infections Systems Research Program, WORK UNIT NUMBER: 847705.82000.25GB.B0016. The sponsor had no role in this study other than providing funding. NR 42 TC 11 Z9 14 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 683 EP 690 DI 10.4269/ajtmh.2010.09-0355 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700030 PM 20348519 ER PT J AU Li, WJ Wang, JL Li, MH Fu, SH Wang, HY Wang, ZY Jiang, SY Wang, XW Guo, P Zhao, SC Shi, Y Lu, NN Nasci, RS Tang, Q Liang, GD AF Li, Wen-Juan Wang, Jing-Lin Li, Ming-Hua Fu, Shi-Hong Wang, Huan-Yu Wang, Zhi-Yu Jiang, Shuang-Ying Wang, Xue-Wen Guo, Peng Zhao, Sheng-Cang Shi, Yan Lu, Nan-Nan Nasci, Roger S. Tang, Qing Liang, Guo-Dong TI Mosquitoes and Mosquito-Borne Arboviruses in the Qinghai-Tibet Plateau-Focused on the Qinghai Area, China SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTIONS; VIRUSES AB An investigation was conducted to identify the distribution of mosquitoes and mosquito-borne arboviruses in the Qinghai-Tibet Plateau, China from July to August in 2007. A total of 8,147 mosquitoes representing six species from three genera (Aedes, Culex, and Anopheles) were collected in three locations (Geermu city, altitude of 2,780 m; Xining city, 2,200 m; Minhe county, 1,700 m). Six virus isolates were obtained including Tahyna virus (TAHV), Liaoning virus, and Culex pipiens Densovirus. A serosurvey showed immunoglobulin G antibodies by immunofluorescence assay (IFA) against TAHV in residents of all three locations. The IFA-positive human samples were confirmed by 90% plaque-reduction neutralization tests (PRNT(90)) against TAHV with titers ranging from 1:20 to 1:10,240. In addition, TAHV seropositive cows, sheep, and swine were found in these locations. This investigation represents the first isolation of TAHV from Ae. (Och.) detritus and the first evidence of TAHV infection in residents and livestock in the Qinghai-Tibet Plateau, C1 [Liang, Guo-Dong] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 100052, Peoples R China. Shandong Univ, Sch Publ Hlth, Key Lab Expt Teratol, Dept Virol,Minist Educ, Jinan 250100, Peoples R China. Qinghai Ctr Dis Control & Prevent, Hlth Inspect & Testing Ctr, Xining, Peoples R China. Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. RP Liang, GD (reprint author), Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, 100 Ying Xin St, Beijing 100052, Peoples R China. EM gdliang@hotmail.com RI Li, Minghua/M-8776-2016 FU Ministry of Science and Technology of China [2003BA712A08-01]; Development Grant of State Key Laboratory for Infectious Disease Prevention and Control [2008SKLID105]; China CDC-United States CDC Cooperative Agreement [U19-GH000004] FX This work was supported by Grant 2003BA712A08-01 from the Ministry of Science and Technology of China. Grant 2008SKLID105 from the Development Grant of State Key Laboratory for Infectious Disease Prevention and Control, and Grant U19-GH000004 from the China CDC-United States CDC Cooperative Agreement. NR 33 TC 14 Z9 24 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 705 EP 711 DI 10.4269/ajtmh.2010.09-0649 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700034 PM 20348523 ER PT J AU Sejvar, JJ Lindblade, KA Arvelo, W Padilla, N Pringle, K Zielinski-Gutierrez, E Farnon, E Schonberger, LB Dueger, E AF Sejvar, James J. Lindblade, Kim A. Arvelo, Wences Padilla, Norma Pringle, Kimberly Zielinski-Gutierrez, Emily Farnon, Eileen Schonberger, Lawrence B. Dueger, Erica TI Clinical Assessment of Self-Reported Acute Flaccid Paralysis in a Population-Based Setting in Guatemala SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID GUILLAIN-BARRE-SYNDROME AB Historically, poliovirus infection has been an important cause of acute flaccid paralysis (AFP) worldwide; however, successful elimination of wild-type poliovirus in much of the world has highlighted the importance of other causes of AFP. Despite the evolving etiology, AFP surveillance in most developing countries still focuses on poliovirus detection and fails to detect many AFP cases, particularly among adults. We assessed 41 subjects self-reporting symptoms suggestive of AFP during a population-based health survey in the Department of Santa Rosa, Guatemala. Thirty-five (85%) of the suspected cases were not hospitalized. Most subjects (37) did not have features consistent with AFP or had other diagnoses explaining weakness. We identified two adults who had not received medical attention for a clinical illness consistent with Guillain-Barre syndrome, the most important cause of non-poliovirus AFP. Usual surveillance methods for AFP, particularly in developing countries, may underestimate the true burden of non-poliovirus AFP. C1 [Sejvar, James J.] CDC, Div Viral & Rickettsial Dis, NCZVED, Atlanta, GA 30333 USA. CDC, Div Vector Borne Infect Dis, NCZVED, Atlanta, GA 30333 USA. CDC, Div Emerging Infect & Surveillance Serv, Natl Ctr Prevent Detect & Control Infect Dis, Atlanta, GA 30333 USA. CDC Univ Valle Guatemala Collaborat, Ctr Estudios Salud, UVG, Guatemala City, Guatemala. Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. RP Sejvar, JJ (reprint author), CDC, Div Viral & Rickettsial Dis, NCZVED, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA. EM zea3@cdc.gov NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 712 EP 716 DI 10.4269/ajtmh.2010.09-0090 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700035 PM 20348524 ER PT J AU Reynolds, MG Carroll, DS Olson, VA Hughes, C Galley, J Likos, A Montgomery, JM Suu-Ire, R Kwasi, MO Root, JJ Braden, Z Abel, J Clemmons, C Regnery, R Karem, K Damon, IK AF Reynolds, Mary G. Carroll, Darin S. Olson, Victoria A. Hughes, Christine Galley, Jack Likos, Anna Montgomery, Joel M. Suu-Ire, Richard Kwasi, Mubarak O. Root, J. Jeffrey Braden, Zach Abel, Jason Clemmons, Cody Regnery, Russell Karem, Kevin Damon, Inger K. TI A Silent Enzootic of an Orthopoxvirus in Ghana, West Africa: Evidence for Multi-Species Involvement in the Absence of Widespread Human Disease SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN MONKEYPOX; VIRUS; SMALLPOX; OUTBREAK; INFECTION; TRANSMISSION; POXVIRUS; IMMUNITY; CONGO AB Human monkeypox has never been reported in Ghana, but rodents captured in forested areas of southern Ghana were the source of the monkeypox virus introduced into the United States in 2003. Subsequent to the outbreak in the United States, 204 animals were collected from two commercial trapping sites in Ghana. Animal tissues were examined for the presence of orthopoxvirus (OPXV) DNA using a real-time polymerase chain reaction, and sera were assayed for antibodies against OPXV. Animals from five genera (Cricetomys, Graphiurus, Funiscirus, and Heliosciurus) had antibodies against OPXV, and three genera (Cricetomys, Graphiurus, and Xerus) had evidence of OPXV DNA in tissues. Additionally, 172 persons living near the trapping sites were interviewed regarding risk factors for OPXV exposure, and their sera were analyzed. Fifty-three percent had IgG against OPXV; none had IgM. Our findings suggest that several species of forest-dwelling rodents from Ghana are susceptible to naturally occurring OPXV infection, and that persons living near forests may have low-level or indirect exposure to OPXV-infected animals, possibly resulting in sub-clinical infections. C1 [Reynolds, Mary G.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. Ghana Minist Hlth, Ghana Hlth Serv, Accra, Ghana. Forestry Commiss, Wildlife Div, Accra, Ghana. Univ Ghana, Coll Hlth Sci, Dept Virol, Noguchi Mem Inst Med Res, Legon, Ghana. USDA, Natl Wildlife Res Ctr, Ft Collins, CO USA. RP Reynolds, MG (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, 1600 Clifton Rd NE,Mailstop G-43, Atlanta, GA 30333 USA. EM nzr6@cdc.gov FU Centers for Disease Control and Prevention; U.S. Department of Agriculture-Animal and Plant Health Inspection Service; government of the Republic of Ghana FX This study was supported by the Centers for Disease Control and Prevention, with participation from U.S. Department of Agriculture-Animal and Plant Health Inspection Service and the government of the Republic of Ghana. NR 24 TC 25 Z9 25 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2010 VL 82 IS 4 BP 746 EP 754 DI 10.4269/ajtmh.2010.09-0716 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 577JR UT WOS:000276219700041 PM 20348530 ER PT J AU Gupta, RS Zhang, XY Springston, EE Sharp, LK Curtis, LM Shalowitz, M Shannon, JJ Weiss, KB AF Gupta, Ruchi S. Zhang, Xingyou Springston, Elizabeth E. Sharp, Lisa K. Curtis, Laura M. Shalowitz, Madeline Shannon, John J. Weiss, Kevin B. TI The association between community crime and childhood asthma prevalence in Chicago SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID PUERTO-RICAN CHILDREN; INNER-CITY ASTHMA; SOCIOECONOMIC-STATUS; VIOLENCE EXPOSURE; BIRTH COHORT; HIGH-RISK; PSYCHOSOCIAL STRESS; UNITED-STATES; URBAN ASTHMA; MORBIDITY AB Background: Little attention has been given to exposure to crime as a possible socioenvironmental contributor to variability in urban childhood asthma prevalence. Objective: To determine the association of violent crime, property crime, and drug abuse violations with childhood asthma prevalence in Chicago. Methods: In 2003-2005, the Chicago Initiative to Raise Asthma Health Equity conducted an asthma screening survey of children in grades K to 8 attending Chicago public and Catholic schools. Crime data were obtained from the Chicago Police Department. In addition to simple regression analysis, multilevel logistic regression analysis was performed to estimate the effect of criminal activity on neighborhood asthma variance. Results: Of the surveys returned, 45,371 (93%) were geocoded into 247 neighborhoods. Neighborhoods were divided into quartile groups by mean asthma prevalence (9%, 12%, 17%, and 22%). Criminal activity (annual incidence per 100,000 people) was significantly higher (P<.001) in neighborhoods with a high asthma prevalence, especially drug abuse violations, which increased more than 6-fold (461 vs 2,921), and violent crimes, which increased more than 3-fold (448 vs 1,566). After adjusting for community race/ethnicity, only violent crime continued to be significantly associated with the neighborhood asthma prevalence (odds ratio, 1.27; 95% confidence interval, 1.04-1.55, P<.05). When considered alongside sociodemographic and individual characteristics, violence continued to contribute significantly (P<.05), explaining 15% of neighborhood variation in childhood asthma. Conclusions: Evidence suggests an association between violent crime and childhood asthma prevalence in Chicago. A deeper understanding of the mechanisms that underlie this association may lend insight into potential interventions to address urban asthma. Ann Allergy Asthma Immunol. 2010; 104: 299-306. C1 [Gupta, Ruchi S.; Springston, Elizabeth E.] Childrens Mem Hosp, Smith Child Hlth Res Program, Chicago, IL 60614 USA. [Gupta, Ruchi S.; Curtis, Laura M.; Weiss, Kevin B.] NW Feinberg Sch Med, Inst Healthcare Studies, Chicago, IL USA. [Zhang, Xingyou] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sharp, Lisa K.] Univ Illinois, Coll Med, Sect Hlth Promot, Chicago, IL USA. [Shalowitz, Madeline] NorthShore Univ HealthSyst, Sect Child & Family Hlth Studies, Evanston, IL USA. [Shannon, John J.] Parkland Hlth & Hosp Syst, Dallas, TX USA. [Weiss, Kevin B.] Amer Board Med Specialties, Evanston, IL USA. RP Gupta, RS (reprint author), Childrens Mem Hosp, Smith Child Hlth Res Program, 2300 Childrens Ave,Box 157, Chicago, IL 60614 USA. EM rugupta@childrensmemorial.org OI Curtis, Laura/0000-0003-2380-2201 FU National Heart, Lung, and Blood Institute [5U01 HL072478-05]; Eunice Kennedy Shriver National Institute of Child Health and Human Development [K12 HD052902]; Robert Wood Johnson Foundation FX This study was supported by grant 5U01 HL072478-05 from the National Heart, Lung, and Blood Institute and by grant K12 HD052902 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Dr. Gupta's time was supported in part by the Robert Wood Johnson Foundation's Physician Faculty Scholars Program. NR 56 TC 19 Z9 19 U1 6 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD APR PY 2010 VL 104 IS 4 BP 299 EP 306 DI 10.1016/j.anai.2009.11.047 PG 8 WC Allergy; Immunology SC Allergy; Immunology GA 701OK UT WOS:000285829400005 PM 20408339 ER PT J AU Zeliadt, S Penson, DF Moinpour, AM Blough, DK Fedorenko, CR Hall, IJ Smith, JL Ekwueme, D Thompson, IM Keane, TE Ramsey, SD AF Zeliadt, Steven Penson, David F. Moinpour, Arol M. Blough, David K. Fedorenko, Catherine R. Hall, Ingrid J. Smith, Judith Lee Ekwueme, Donatus Thompson, Ian M. Keane, Thomas E. Ramsey, Scott D. TI PROVIDER INTERACTIONS WITH PARTNERS OF MEN NEWLY DIAGNOSED WITH PROSTATE CANCER SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Zeliadt, Steven] VA Puget Sound Hlth Care Syst, Seattle, WA 98101 USA. [Zeliadt, Steven; Penson, David F.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Moinpour, Arol M.; Fedorenko, Catherine R.; Ramsey, Scott D.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Blough, David K.] Univ Washington, Seattle, WA 98195 USA. [Hall, Ingrid J.; Smith, Judith Lee; Ekwueme, Donatus] Ctr Dis Control & Prevent, Atlanta, GA USA. [Thompson, Ian M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Keane, Thomas E.] Med Univ S Carolina, Charleston, SC 29425 USA. EM szeliadt@u.washington.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2010 VL 39 SU 1 BP 5 EP 5 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 572OF UT WOS:000275841700017 ER PT J AU Harmond, L Faulkenberry, R Powe, B Cooper, D AF Harmond, Lokie Faulkenberry, Rachel Powe, Barbara Cooper, Dexter TI THE FUTURE OF SURVEY METHODS: USING AN AUDIENCE RESPONSE TECHNOLOGY SYSTEM TO COLLECT RESEARCH DATA AMONG AFRICAN AMERICAN ELDERS SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Harmond, Lokie; Powe, Barbara; Cooper, Dexter] Amer Canc Soc, Behav Res Ctr, Atlanta, GA 30303 USA. [Faulkenberry, Rachel] Ctr Dis Control & Prevent, Atlanta, GA USA. EM lokie.harmond@cancer.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2010 VL 39 SU 1 BP 75 EP 75 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 572OF UT WOS:000275841700289 ER PT J AU Wellington, R Stewart, SL AF Wellington, Robin Stewart, Sherri L. TI ANATOMIC INCIDENCE OF PRIMARY BRAIN TUMORS IN THE UNITED STATES SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Wellington, Robin] St Johns Univ, Jamaica, NY 11439 USA. [Stewart, Sherri L.] CDC, Atlanta, GA 30333 USA. EM wellingr@stjohns.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2010 VL 39 SU 1 BP 76 EP 76 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 572OF UT WOS:000275841700294 ER PT J AU Reiter, PL Cates, JR McRee, AL Gottlieb, SL Smith, JS Brewer, NT AF Reiter, Paul L. Cates, Joan R. McRee, Annie-Laurie Gottlieb, Sami L. Smith, Jennifer S. Brewer, Noel T. TI STATEWIDE HPV VACCINE INITIATION AMONG ADOLESCENT FEMALES IN NORTH CAROLINA SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Reiter, Paul L.; Cates, Joan R.; McRee, Annie-Laurie; Smith, Jennifer S.; Brewer, Noel T.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Gottlieb, Sami L.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM preiter@email.unc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2010 VL 39 SU 1 BP 131 EP 131 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 572OF UT WOS:000275841700507 ER PT J AU Nelson, SJ Hughes, JP Foxman, B Aral, SO Holmes, KK White, PJ Golden, MR AF Nelson, Sara J. Hughes, James P. Foxman, Betsy Aral, Sevgi O. Holmes, King K. White, Peter J. Golden, Matthew R. TI Age- and Gender-Specific Estimates of Partnership Formation and Dissolution Rates in the Seattle Sex Survey SO ANNALS OF EPIDEMIOLOGY LA English DT Article; Proceedings Paper CT 17th Meeting of the International-Society-for-Sexually-Transmitted-Diseases-Research CY JUL 29-AUG 01, 2007 CL Seattle, WA SP Int Soc Sexually Transmitted Dis Res DE Heterosexual; Partnerships; Mathematical Modeling; Random Digit Dialing Survey; Sexually Transmitted Diseases; Epidemiology ID MATHEMATICAL-MODELS; TRANSMISSION; POPULATION; INFECTION; GONORRHEA; SPREAD AB PURPOSE: Partnership formation and dissolution rates are primary determinants of sexually transmitted infection (STI) transmission dynamics. METHODS: The authors used data on persons' lifetime sexual experiences from a 2003-2004 random digit dialing survey of Seattle residents aged 18-39 years (N = 1,194) to estimate age- and gender-specific partnership formation and dissolution rates. Partnership start and end dates were used to estimate participants' ages at the start of each partnership and partnership durations, and partnerships not enumerated in the survey were imputed. RESULTS: Partnership formation peaked at age 19 at 0.9 (95% confidence interval [CI]: 0.76-1.04) partnerships per year and decreased to 0.1 to 0.2 after age 30 for women and peaked at age 20 at 1.4 (95% Cl: 1.08-1.64) and declined to 0.5 after age 30 for men. Nearly one fourth (23.7%) of partnerships ended within 1 week and more than one half (51.2%) ended within 12 weeks. Most (63.5%) individuals 30 to 39 years of age had not formed a new sexual partnership in the past 3 years. CONCLUSION: A large proportion of the heterosexual population is no longer at substantial STI risk by their early 30s, but similar analyses among high-risk populations may give insight into reasons for the profound disparities in STI rates across populations. Ann Epidemiol 2010;20:308-317. (C) 2010 Elsevier Inc. All rights reserved. C1 [Nelson, Sara J.] Univ Washington, Ctr AIDS & STD, Harborview Med Ctr, Dept Epidemiol, Seattle, WA 98104 USA. [Hughes, James P.] Univ Washington, Dept Biostat, Seattle, WA 98104 USA. [Holmes, King K.; Golden, Matthew R.] Univ Washington, Dept Med, Seattle, WA 98104 USA. [Holmes, King K.] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA. [Foxman, Betsy] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA. [Aral, Sevgi O.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [White, Peter J.] Hlth Protect Agcy Ctr Infect, Modelling & Econ Unit, London, England. [White, Peter J.] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Outbreak Anal & Modelling, Dept Infect Dis Epidemiol, London, England. RP Nelson, SJ (reprint author), Univ Washington, Ctr AIDS & STD, Harborview Med Ctr, Dept Epidemiol, 325 9th Ave,Box 359931, Seattle, WA 98104 USA. EM sjnelson@u.washington.edu OI Foxman, Betsy/0000-0001-6682-238X FU Medical Research Council [G0600719, ]; NIAID NIH HHS [R01 AI068107, R01 AI 068107-01, T32 AI007140-32, R01 AI068107-05, T32 AI 007140, T32 AI007140] NR 18 TC 11 Z9 11 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD APR PY 2010 VL 20 IS 4 BP 308 EP 317 DI 10.1016/j.annepidem.2009.11.003 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 578DS UT WOS:000276274300008 PM 20071193 ER PT J AU Griffing, S Syphard, L Sridaran, S McCollum, AM Mixson-Hayden, T Vinayak, S Villegas, L Barnwell, JW Escalante, AA Udhayakumar, V AF Griffing, Sean Syphard, Luke Sridaran, Sankar McCollum, Andrea M. Mixson-Hayden, Tonya Vinayak, Sumiti Villegas, Leopoldo Barnwell, John W. Escalante, Ananias A. Udhayakumar, Venkatachalam TI pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PAPUA-NEW-GUINEA; REAL-TIME PCR; DRUG-RESISTANCE; SOUTH-AMERICA; MEFLOQUINE RESISTANCE; COPY NUMBER; ANTIMALARIAL RESISTANCE; MULTIDRUG-RESISTANCE; QUININE RESISTANCE; MALARIA PARASITES AB Molecular tools are valuable for determining evolutionary history and the prevalence of drug-resistant malaria parasites. These tools have helped to predict decreased sensitivity to antimalarials and fixation of multidrug resistance genotypes in some regions. In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug resistance. We examined pfmdr1 and pfcrt in samples from Sifontes, Venezuela, and integrated our findings with earlier work describing dhfr and dhps in these samples. We characterized pfmdr1 genotypes and copy number variation, pfcrt genotypes, and proximal microsatellites in 93 samples originating from surveillance from 2003 to 2004. Multicopy pfmdr1 was found in 12% of the samples. Two pfmdr1 alleles, Y184F/N1042D/D1246Y (37%) and Y184F/S1034C/N1042D/D1246Y (63%), were found. These alleles share ancestry, and no evidence of strong selective pressure on mutations was found. pfcrt chloroquine resistance alleles are fixed with two alleles: StctVMNT (91%) and SagtVMNT (9%). These alleles are associated with strong selection. There was also an association between pfcrt, pfmdr1, dhfr, and dhps genotypes/haplotypes. Duplication of pfmdr1 suggests a potential shift in mefloquine sensitivity in this region, which warrants further study. A bottleneck occurred in P. falciparum in Sifontes, Venezuela, and multidrug resistance genotypes are present. This population could be targeted for malaria elimination programs to prevent the possible spread of multidrug-resistant parasites. C1 [Griffing, Sean; Syphard, Luke; Sridaran, Sankar; McCollum, Andrea M.; Mixson-Hayden, Tonya; Vinayak, Sumiti; Barnwell, John W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA 30341 USA. [Griffing, Sean] Emory Univ, Atlanta, GA 30322 USA. [Syphard, Luke; Sridaran, Sankar] Assoc Publ Hlth Labs, Silver Spring, MD USA. [Villegas, Leopoldo] Asociac Civil Impacto Social, Tumeremo, Venezuela. [Escalante, Ananias A.] Arizona State Univ, Tempe, AZ USA. [Sridaran, Sankar; McCollum, Andrea M.; Mixson-Hayden, Tonya; Vinayak, Sumiti] Atlanta Res & Educ Fdn, Decatur, GA USA. RP Udhayakumar, V (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, 4770 Buford Highway NE,Bldg 22,Rm 2, Atlanta, GA 30341 USA. EM vxu0@cdc.gov RI Vinayak, Sumiti/F-9395-2013 FU Antimicrobial Drug Resistance Working Group; Centers for Disease Control and Prevention; Atlanta Research and Education Foundation; Atlanta VA Medical Center; U.S. Agency for International Development; National Science Foundation; Association of Public Health Laboratories; National Institutes of Health [R01GM084320] FX This work was financially supported in part by the Antimicrobial Drug Resistance Working Group, Centers for Disease Control and Prevention, Atlanta Research and Education Foundation, Atlanta VA Medical Center, and the U.S. Agency for International Development-supported Amazon Malaria Initiative. S. Griffing was supported by a National Science Foundation Graduate Research Fellowship. Luke Syphard and Sankar Sridaran were supported by Emerging Infectious Diseases fellowships from the Association of Public Health Laboratories. Andrea M. McCollum, Tonya Mixson-Hayden, and Sumiti Vinayak were supported by the Atlanta Research and Education Foundation. A. A. Escalante is supported by grant R01GM084320 from the National Institutes of Health. NR 52 TC 34 Z9 35 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2010 VL 54 IS 4 BP 1572 EP 1579 DI 10.1128/AAC.01243-09 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 570HG UT WOS:000275662700024 PM 20145087 ER PT J AU Lingappa, VR Lingappa, U Borst, E Pajda, J Brown, I Long, S Rami, B Nalca, A Lipkin, WI Rupprecht, C Messerle, M Hurtl, CR Hansen, W AF Lingappa, Vishwanath R. Lingappa, Usha Borst, Eva Pajda, Jacqueline Brown, Ian Long, Scott Rami, Bhadresh Nalca, Aysegul Lipkin, W. Ian Rupprecht, Charles Messerle, Martin Hurtl, Clarence R. Hansen, William TI Overlap in Virus Specificity Leads to the Discovery of Small Molecules Active Against Rabies Virus, Cytomegalovirus, and Monkey Pox Virus SO ANTIVIRAL RESEARCH LA English DT Meeting Abstract CT 23rd International Conference on Antiviral Research CY APR 25-28, 2010 CL San Francisco, CA SP Int Soc Antiviral Res C1 [Lingappa, Vishwanath R.; Lingappa, Usha; Brown, Ian; Long, Scott; Rami, Bhadresh; Hurtl, Clarence R.; Hansen, William] Prosetta Bioconformat, San Francisco, CA USA. [Pajda, Jacqueline] CUBRC Inc, Buffalo, NY USA. [Nalca, Aysegul] USAMRIID, Div Aerobiol Sci, Ft Detrick, MD USA. [Lipkin, W. Ian] Columbia Univ, New York, NY USA. [Messerle, Martin] Hannover Med Sch, D-3000 Hannover, Germany. [Rupprecht, Charles] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2010 VL 86 IS 1 MA 142 BP A60 EP A61 DI 10.1016/j.antivira1.2010.02.452 PG 2 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 598CH UT WOS:000277809600121 ER PT J AU Horner-Johnson, W Krahn, GL Suzuki, R Peterson, JJ Roid, G Hall, T AF Horner-Johnson, Willi Krahn, Gloria L. Suzuki, Rie Peterson, Jana J. Roid, Gale Hall, Trevor CA RRTC Expert Panel Hlth Measurement TI Differential Performance of SF-36 Items in Healthy Adults With and Without Functional Limitations SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Bias; Disabled persons; Health surveys; Rehabilitation ID SPINAL-CORD-INJURY; QUALITY-OF-LIFE; PHYSICAL FUNCTION; OUTCOMES; PARTICIPATION; INSTRUMENTS AB Horner-Johnson W, Krahn GL, Suzuki R, Peterson JJ, Roid G, Flail T, the RRTC Expert Panel on Health Measurement. Differential performance of SF-36 items in healthy adults with and without functional limitations. Arch Phys Med Rehabil 2010;91:570-5. Objective: To determine whether Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) items show differential item functioning among healthy adults with various types of functional limitations as compared with a healthy sample with no identified limitations. Design: Survey responses were analyzed by using partial correlations. Setting: General community. Participants: Participants (N=206) included (1) adults with spinal cord injury (SCI), (2) adults who were deaf or hard of hearing, (3) adults who were legally blind, (4) adults with psychiatric or emotional conditions, and (5) adults with no reported functional limitations. Participants were screened to ensure the absence of substantial health problems. Interventions: Not applicable. Main Outcome Measure: SF-36. Results: Partial correlations showed a significant negative correlation, indicating differential item functioning (ie, apparent bias) for people with SCI on all 10 SF-36 Physical Functioning items. For people who were blind, 5 items showed a significant negative correlation. Two items had significant negative correlations for the deaf/hard-of-hearing group. One item showed significant negative performance for people with mental health conditions. Conclusions: Our data indicated a possibility for measurement bias caused by the blending of health and function concepts in the SF-36. C1 [Horner-Johnson, Willi; Peterson, Jana J.] Oregon Hlth & Sci Univ, Oregon Inst Disabil & Dev, Portland, OR 97201 USA. [Horner-Johnson, Willi; Peterson, Jana J.] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA. [Krahn, Gloria L.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Suzuki, Rie] Univ Michigan, Dept Hlth Sci & Adm, Flint, MI 48503 USA. [Hall, Trevor] NW Neurobehav Hlth, Boise, ID USA. RP Horner-Johnson, W (reprint author), Oregon Hlth & Sci Univ, Oregon Inst Disabil & Dev, POB 574, Portland, OR 97201 USA. EM hornerjo@ohsu.edu OI Horner-Johnson, Willi/0000-0003-3568-1400 FU Department of Education, NIDRR [H133B040034] FX The contents of this article were developed under a grant from the Department of Education, NIDRR grant number H133B040034. However, those contents do not necessarily represent the policy of the Department of Education, and you should not assume endorsement by the Federal Government. NR 30 TC 18 Z9 19 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD APR PY 2010 VL 91 IS 4 BP 570 EP 575 DI 10.1016/j.apmr.2009.12.015 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 587OL UT WOS:000277002000011 PM 20382289 ER PT J AU Sacks, JJ Luo, YH Helmick, CG AF Sacks, Jeffrey J. Luo, Yao-Hua Helmick, Charles G. TI Prevalence of Specific Types of Arthritis and Other Rheumatic Conditions in the Ambulatory Health Care System in the United States, 2001-2005 SO ARTHRITIS CARE & RESEARCH LA English DT Article ID RECORDS AB Objective. To estimate the overall prevalence of medically-treated arthritis and other rheumatic conditions (AORC) for adults, the prevalence of specific medically-treated conditions, and the overall annual number of visits for these conditions in the ambulatory health care system. Methods. We used data from the 2001-2005 National Ambulatory Medical Care Survey and 2001-2005 National Hospital Ambulatory Medical Care Survey to estimate annual ambulatory health care visits for the International Classification of Diseases, Ninth Revision, Clinical Modification codes thought to represent AORC. Using data on the number of prior annual visits per patient per condition, we converted the visit estimates into prevalence estimates of adults age >= 18 years with medically-treated AORC overall and for specific conditions. Results. The overall prevalence estimate of adults with medically-treated AORC was 29,150,000 adults (95% confidence interval [95% CI] 26,473,000-31,826,000) and accounted for 77,887,300 ambulatory care visits (95% CI 71,266,000-84,508,000). The top 5 most prevalent conditions were osteoarthritis and allied disorders, unspecified joint disorders, peripheral enthesopathies, unspecified arthropathies, and other disorders of synovium, tendon, or bursa. Conclusion. The advantage of our approach is that it uses existing rather than expensive new surveys for tracking the prevalence of medically-treated AORC overall and tracking the prevalence of difficult to measure specific conditions. The estimates are data based and national in scope. More relevantly, they better estimate the numbers of persons whose AORC impacts on the ambulatory health care system. C1 [Helmick, Charles G.] CDC, Arthrit Program, Atlanta, GA 30341 USA. [Sacks, Jeffrey J.] Sue Binder Consulting, Atlanta, GA USA. [Luo, Yao-Hua] Business Comp Applicat, Atlanta, GA USA. RP Helmick, CG (reprint author), CDC, Arthrit Program, 4770 Buford Highway,K51, Atlanta, GA 30341 USA. EM CHelmick@cdc.gov NR 13 TC 43 Z9 44 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2151-464X J9 ARTHRIT CARE RES JI Arthritis Care Res. PD APR PY 2010 VL 62 IS 4 BP 460 EP 464 DI 10.1002/acr.20041 PG 5 WC Rheumatology SC Rheumatology GA 639MR UT WOS:000280979400005 PM 20391499 ER PT J AU Date, AA Vitoria, M Granich, R Banda, M Fox, MY Gilks, C AF Date, Anand A. Vitoria, Marco Granich, Reuben Banda, Mazuwa Fox, Mayada Youssef Gilks, Charlie TI Implementation of co-trimoxazole prophylaxis and isoniazid preventive therapy for people living with HIV SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; POSITIVE TUBERCULOSIS PATIENTS; ADJUNCTIVE COTRIMOXAZOLE; COTE-DIVOIRE; TRIMETHOPRIM-SULFAMETHOXAZOLE; OPPORTUNISTIC INFECTIONS; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; COST-EFFECTIVENESS; REDUCES MORTALITY AB Objective To measure progress in implementing co-trimoxazole prophylaxis (CTXp) (trimethoprim plus sulfamethoxazole) and isoniazid preventive therapy (IPT) policy recommendations, identify barriers to the development of national policies and pinpoint challenges to implementation. Methods In 2007 we conducted by e-mail a cross-sectional survey of World Health Organization (WHO) HIV/AIDS programme officers in 69 selected countries having a high burden of infection with HIV or HIV-associated tuberculosis (TB). The specially-designed, self-administered questionnaire contained items covering national policies for CTXp and IPT in people living with HIV, current level of implementation and barriers to developing or implementing these policies. Findings The 41(59%) respondent countries, representing all WHO regions, comprised 85% of the global burden of HIV-associated TB and 82% of the global burden of HIV infection. Thirty-eight countries (93%) had an established national policy for CTXp, but only 66% of them (25/38) had achieved nationwide implementation. For IPT, 21 of 41 countries (51%) had a national policy but only 28% of them (6/21) had achieved nationwide implementation. Despite significant progress in the development of CTXp policy, the limited availability of co-trimoxazole for this indication and inadequate systems to manage drug supply impeded nationwide implementation. Inadequate intensified tuberculosis case-finding and concerns regarding isoniazid resistance were challenges to the development and implementation of national IPT policies. Conclusion Despite progress in implementing WHO-recommended CTXp and IPT policies, these interventions remain underused. Urgent steps are required to facilitate the development and implementation of these policies. C1 [Date, Anand A.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA 30333 USA. [Vitoria, Marco; Granich, Reuben; Banda, Mazuwa; Fox, Mayada Youssef; Gilks, Charlie] World Hlth Org, HIV AIDS Dept, Geneva, Switzerland. RP Date, AA (reprint author), Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA 30333 USA. EM adate@cdc.gov RI Gilks, Charles/B-4184-2012 NR 41 TC 41 Z9 43 U1 0 U2 4 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD APR PY 2010 VL 88 IS 4 BP 253 EP 259 DI 10.2471/BLT.09.066522 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 584JU UT WOS:000276748800012 PM 20431788 ER PT J AU Deak, E Etienne, KA Lockhart, SR Gade, L Chiller, T Balajee, SA AF Deak, Eszter Etienne, Kizee A. Lockhart, Shawn R. Gade, Lalitha Chiller, Tom Balajee, S. Arunmozhi TI Utility of a Luminex-based assay for multiplexed, rapid species identification of Candida isolates from an ongoing candidemia surveillance SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE Luminex; Candida; species identification ID FLOW-CYTOMETRY; XMAP TECHNOLOGY; DNA PROBES; SYSTEM; YEASTS AB A Candida-specific Luminex-based assay with 11 probes was employed for multiplexed, rapid identification of 1182 Candida sp. isolates that were received as part of an ongoing population-based surveillance. All the Candida isolates were previously identified by a combination of methods, including phenotype and sequence analysis. Results showed that the Luminex assay was an attractive alternative to reference methods, as it is rapid, yields correct species identification, and is user friendly. C1 [Deak, Eszter; Etienne, Kizee A.; Lockhart, Shawn R.; Gade, Lalitha; Chiller, Tom; Balajee, S. Arunmozhi] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. RP Balajee, SA (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,Mailstop G11, Atlanta, GA 30333 USA. EM fir3@cdc.gov NR 12 TC 20 Z9 20 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD APR PY 2010 VL 56 IS 4 BP 348 EP 351 DI 10.1139/W10-003 PG 4 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA 610XX UT WOS:000278774600009 PM 20453902 ER PT J AU Jain, RB Wang, RY AF Jain, Ram B. Wang, Richard Y. TI Regression models to estimate total polychlorinated biphenyls in the general US population: 2001-2002 and 2003-2004 SO CHEMOSPHERE LA English DT Article DE PCB; Congeners; Limit of detection; Geometric mean; NHANES ID ENVIRONMENTAL CHEMICALS; PREGNANT-WOMEN; HUMAN-SERUM; HUMAN-MILK; ORGANOCHLORINES; CONGENERS; EXPOSURE AB Certain polychlorinated biphenyls (PCB) have long half-lives and, despite the regulatory bans on the industrial pollutants that expose humans to PCB, are detectable in human serum. However, many of them are not detectable because of the small quantities that may be present in body fluids. For this reason, attempts have been made to estimate the total concentration of PCB (Sigma PCB) using the relationship between Sigma PCB and the concentrations of a few of the PCB congeners which can be reliably measured at detectable levels. PCB 153 or a combination of PCB 153, 138, and 180 have previously been used for this purpose. However, because of the unique populations investigated in these studies, the results are not necessarily applicable to the racially/ethnically heterogeneous US population. We defined Sigma PCB as the sum of the concentrations of 12 PCB congeners, and sum of 33 PCB congeners for NHANES 2001-2002 and 2003-2004 respectively. We built regression models in a step-wise fashion using Sigma PCB as the dependent variable and age, race/ethnicity, and gender as the covariates for both whole-weight and lipid-adjusted data. In addition, concentration of PCB 153 was used as the continuous independent variable for 2001-2002 models, and PCB 153 and PCB 180 for 2003-2004 models respectively. R(2) for both models for NHANES 2001-2002 was >86%. The R(2) for both NHANES 2003-2004 models was >81%. Thus, the estimate of Sigma PCB for the general US population can be improved by considering common demographic variables, such as race/ethnicity, and selected congeners. Published by Elsevier Ltd. C1 [Jain, Ram B.; Wang, Richard Y.] Ctr Dis Control & Prevent, Chamblee, GA 30329 USA. RP Jain, RB (reprint author), Ctr Dis Control & Prevent, Mail Stop F-47,4770 Buford Highway, Chamblee, GA 30329 USA. EM rij0@cdc.gov NR 18 TC 10 Z9 10 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2010 VL 79 IS 3 BP 243 EP 252 DI 10.1016/j.chemosphere.2010.02.013 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA 582WL UT WOS:000276630800001 PM 20189219 ER PT J AU Klevens, J Leeb, RT AF Klevens, Joanne Leeb, Rebecca T. TI Child maltreatment fatalities in children under 5: Findings from the National Violence Death Reporting System SO CHILD ABUSE & NEGLECT LA English DT Article DE Surveillance; Child physical abuse; Inflicted traumatic brain injury; Inflicted childhood neurotrauma; Abusive head trauma ID TRAUMATIC BRAIN-INJURY; PUBLIC-HEALTH SURVEILLANCE; YOUNG-CHILDREN; UNITED-STATES; ABUSE; POPULATION; NEGLECT; IMPACT AB Objective: To describe the distribution of child maltreatment fatalities of children under 5 by age, sex, race/ethnicity, type of maltreatment, and relationship to alleged perpetrator using data from the National Violent Death Reporting System (NVDRS). Study design: Two independent coders reviewed information from death certificates, medical examiner and police reports corresponding to all deaths in children less than 5 years of age reported to NVDRS in 16 states. Results: Of the 1,374 deaths for children under 5 reported to NVDRS, 600 were considered attributable to child maltreatment. Over a half of the 600 victims of child maltreatment in this age group were under 1 year old, 59% were male, 42% non-Hispanic Whites, and 38% were non-Hispanic Blacks. Two thirds of child maltreatment fatalities in children under 5 were classified as being due to abusive head trauma (AHT), 27.5% as other types of physical abuse, and 10% as neglect. Based on these data, fathers or their substitutes were significantly more likely than mothers to be identified as alleged perpetrators for AHT and other types of physical abuse, while mothers were more likely to be assigned responsibility for neglect. Conclusions: Among children under 5 years, children under 1 are the main age group contributing to child maltreatment fatalities in the NVDRS. AHT is the main cause of death in these data. These findings are limited by underascertainment of cases and fair inter-rater reliability of coding. Practice implications: The findings suggest the need to develop and evaluate interventions targeting AHT to reduce the overall number of child maltreatment deaths in young children. These interventions should make special efforts to include fathers and their substitutes. Published by Elsevier Ltd. C1 [Klevens, Joanne; Leeb, Rebecca T.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Klevens, J (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F-64, Atlanta, GA 30341 USA. NR 35 TC 25 Z9 25 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0145-2134 J9 CHILD ABUSE NEGLECT JI Child Abuse Negl. PD APR PY 2010 VL 34 IS 4 BP 262 EP 266 DI 10.1016/j.chiabu.2009.07.005 PG 5 WC Family Studies; Psychology, Social; Social Work SC Family Studies; Psychology; Social Work GA 588LW UT WOS:000277072700006 PM 20304491 ER PT J AU Handali, S Klarman, M Gaspard, AN Dong, XF LaBorde, R Noh, J Lee, YM Rodriguez, S Gonzalez, AE Garcia, HH Gilman, RH Tsang, VCW Wilkins, PP AF Handali, Sukwan Klarman, Molly Gaspard, Amanda N. Dong, X. Fan LaBorde, Ronald Noh, John Lee, Yeuk-Mui Rodriguez, Silvia Gonzalez, Armando E. Garcia, Hector H. Gilman, Robert H. Tsang, Victor C. W. Wilkins, Patricia P. TI Development and Evaluation of a Magnetic Immunochromatographic Test To Detect Taenia solium, Which Causes Taeniasis and Neurocysticercosis in Humans SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED IMMUNOELECTROTRANSFER BLOT; IMMUNOSORBENT-ASSAY; SYNTHETIC 8-KD; ANTIGENS; CYSTICERCOSIS; CLONING; SERODIAGNOSIS; DIAGNOSIS; GP50 AB Taeniasis/cysticercosis caused by Taenia solium is a frequent parasitic infection of the human brain in most of the world. Rapid and simple screening tools to identify taeniasis and cysticercosis cases are needed for control programs, mostly to identify tapeworm carriers which are the source of infection and need to be treated, or as tools for point-of-care case detection or confirmation. These screening assays should be affordable, reliable, rapid, and easy to perform. Immunochromatographic tests meet these criteria. To demonstrate proof of principle, we developed and evaluated two magnetic immunochromatographic tests (MICTs) for detection of human Taenia solium taeniasis antibodies (ES33-MICT) and neurocysticercosis antibodies (T24-MICT). These assays detected stage-specific antibodies by using two recombinant proteins, rES33 for detection of taeniasis antibodies and rT24H for detection of cysticercosis antibodies. The sensitivity and specificity of the ES33-MICT to detect taeniasis infections were 94.5% and 96%, respectively, and those of the T24-MICT to detect cases of human cysticercosis with two or more viable brain cysts were 93.9% and 98.9%, respectively. These data provide proof of principle that the ES33- and T24-MICTs provide rapid and suitable methods to identify individuals with taeniasis and cysticercosis. C1 [Handali, Sukwan; Klarman, Molly; Gaspard, Amanda N.; Noh, John; Lee, Yeuk-Mui; Wilkins, Patricia P.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Dong, X. Fan] Pacific BioPharm, San Diego, CA USA. [LaBorde, Ronald] MagnaBioSciences, San Diego, CA USA. [Rodriguez, Silvia; Garcia, Hector H.] Inst Ciencias Neurol, Cysticercosis Unit, Lima, Peru. [Gonzalez, Armando E.] Univ San Marcos, Sch Vet Med, Lima, Peru. [Gonzalez, Armando E.; Garcia, Hector H.; Gilman, Robert H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Ctr Global Hlth, Lima, Peru. [Tsang, Victor C. W.] Georgia State Univ, Dept Biol, Atlanta, GA USA. RP Handali, S (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. EM ahi0@cdc.gov FU Bill & Melinda Gates Foundation [23981]; CDC Epilepsy Program; Fogarty International Center [D43 TW001140] FX This work was supported in part by the Bill & Melinda Gates Foundation grant 23981, the CDC Epilepsy Program, and the Fogarty International Center training grant D43 TW001140 (to H. H. G.). NR 25 TC 32 Z9 33 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2010 VL 17 IS 4 BP 631 EP 637 DI 10.1128/CVI.00511-09 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 576TG UT WOS:000276170900021 PM 20181766 ER PT J AU Teshale, EH Grytdal, SP Howard, C Barry, V Kamili, S Drobeniuc, J Hill, VR Okware, S Hu, DJ Holmberg, SD AF Teshale, Eyasu H. Grytdal, Scott P. Howard, Christopher Barry, Vaughn Kamili, Saleem Drobeniuc, Jan Hill, Vincent R. Okware, Samuel Hu, Dale J. Holmberg, Scott D. TI Evidence of Person-to-Person Transmission of Hepatitis E Virus during a Large Outbreak in Northern Uganda SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID NON-B-HEPATITIS; TRANSMITTED NON-A; EPIDEMIC; SPREAD; INFECTION; HEV AB Background. Outbreaks of infection with hepatitis E virus (HEV) are frequently attributed to contaminated drinking water, even if direct evidence for this is lacking. Methods. We conducted several epidemiologic investigations during a large HEV infection outbreak in Uganda. Results. Of 10,535 residents, 3218 had HEV infection; of these, 2531 lived in households with > 1 case. HEV was not detected in drinking water or zoonotic sources. Twenty-five percent of cases occurred >= 8 weeks after onset of hepatitis in an index case in the household. Households with >= 2 cases were more likely to have a member(s) who attended a funeral, had close contact with a jaundiced person, or washed hands in a common basin with others (P < .05 for all). Conclusions. A high attack rate in households, lack of a common source of infection, and poor hygienic practices in households with >= 2 cases suggest person-to-person transmission of HEV during this outbreak. C1 [Teshale, Eyasu H.; Grytdal, Scott P.; Barry, Vaughn; Kamili, Saleem; Drobeniuc, Jan; Hu, Dale J.; Holmberg, Scott D.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Howard, Christopher] Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Hill, Vincent R.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Okware, Samuel] Uganda Natl Hlth Res Org, Kampala, Uganda. RP Teshale, EH (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV Hepatitis STD & TB Prevent, 1600 Clifton Rd NE,Mailstop G-37, Atlanta, GA 30333 USA. EM eht4@cdc.gov RI Hill, Vincent/G-1789-2012 OI Hill, Vincent/0000-0001-7069-7737 FU Ugandan Ministry of Health; World Health Organization; UNICEF; United Nations High Commission for Refugees; Medecins sans Frontiers; St. Joseph Hospital; Kitgum Hospital; Madi Opei Level 4 Health Center; Centers for Disease Control and Prevention in Uganda FX We thank our many helpful partners: the Ugandan Ministry of Health; colleagues at the World Health Organization, UNICEF, United Nations High Commission for Refugees, and Medecins sans Frontiers; St. Joseph Hospital, Kitgum Hospital, and Madi Opei Level 4 Health Center; and especially the residents of Kitgum District, Uganda. We also thank the management staff of the Centers for Disease Control and Prevention in Uganda for their support throughout the investigation and the Tororo HIV outreach team. We also thank Tracy Greene-Montfort for testing the samples. NR 25 TC 55 Z9 56 U1 0 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 1 PY 2010 VL 50 IS 7 BP 1006 EP 1010 DI 10.1086/651077 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 563YO UT WOS:000275176900009 PM 20178415 ER PT J AU Paz-Bailey, G Sternberg, M Puren, AJ Steele, L Lewis, DA AF Paz-Bailey, Gabriela Sternberg, Maya Puren, Adrian J. Steele, Lisa Lewis, David A. TI Determinants of HIV Type 1 Shedding from Genital Ulcers among Men in South Africa SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HERPES-SIMPLEX-VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; EPIDEMIOLOGIC SYNERGY; HAEMOPHILUS-DUCREYI; RISK-FACTORS; INFECTION; WOMEN; TRANSMISSION; ACQUISITION AB Background. Our study evaluated correlates of human immunodeficiency virus (HIV)-1 lesional shedding among men with genital ulcer disease (GUD). Methods. Participants were recruited at primary health care clinics as part of a randomized trial of episodic acyclovir among men with GUD. This analysis was done among HIV-positive men identified at baseline. Participants were serologically screened for HIV infection, syphilis, and herpes simplex virus type 2 infection and for urethritis and ulcer etiology by polymerase chain reaction. Plasma and genital ulcer HIV-1 loads and CD4 cell counts were quantified. We evaluated variables associated with the presence and quantity of HIV-1 in ulcers. Results. Among 387 HIV-positive men, the median plasma HIV-1 load and CD4 cell count were 87,200 copies/mL and 282 cells/mm(3). Overall, 173 (45.6%) had detectable HIV-1 RNA in ulcers. Men with Trichomonas vaginalis infection had higher ulcer viral loads on average than did those who were not infected (mean difference, 0.62; 95% confidence interval [CI], 0.07-1.2; P = .027). After multivariable analysis, higher plasma HIV-1 load (odds ratio [OR], 2.5; 95% CI, 1.7-3.5; P < .001), larger lesions (OR, 2.5; 95% CI, 1.5-4.1; P < .001), purulent ulcers (OR, 2.2; 95% CI, 1.1-4.2; P = .02), multiple ulcers (> 5; OR, 3.6; 95% CI, 1.6-8.4; P = .002), and herpes seropositivity (OR, 3.4; 95% CI, 1.7-7.0; P < .001) remained associated with increased odds of HIV-1 lesional shedding. Ulcers associated with herpes simplex virus type 2 infection were less likely to shed (OR, 0.6; 95% CI, 0.3-1.0; P = .05), compared with ulcers with unknown etiology. Conclusions. HIV-positive men should be screened and treated for GUD to minimize HIV shedding and transmission to uninfected sexual partners. C1 [Paz-Bailey, Gabriela; Lewis, David A.] London Sch Hyg & Trop Med, London WC1, England. [Paz-Bailey, Gabriela; Sternberg, Maya; Steele, Lisa] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. [Puren, Adrian J.] Univ Witwatersrand, Specialized Mol Diagnost Unit, Johannesburg, South Africa. [Lewis, David A.] Univ Witwatersrand, STI Reference Ctr, Natl Inst Communicable Dis, Natl Hlth Lab Serv, Johannesburg, South Africa. [Lewis, David A.] Univ Witwatersrand, Dept Internal Med, Johannesburg, South Africa. RP Paz-Bailey, G (reprint author), Del Valle Univ Guatemala, Ctr Hlth Studies, 18 Ave 11-42 Zona 15 Vista Hermosa III, Guatemala City 01015, Guatemala. EM gpaz@gt.cdc.gov FU US Centers for Disease Control and Prevention FX Financial support. US Centers for Disease Control and Prevention. G. P.- B., M. S., and L. S. were all employed by the Centers for Disease Control and Prevention and were involved at different stages in the study including: the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. NR 40 TC 18 Z9 19 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 1 PY 2010 VL 50 IS 7 BP 1060 EP 1067 DI 10.1086/651115 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 563YO UT WOS:000275176900017 PM 20178417 ER PT J AU Plantinga, LC Crews, DC Coresh, J Miller, ER Saran, R Yee, J Hedgeman, E Paykov, M Eberhardt, MS Williams, DE Powe, NR AF Plantinga, Laura C. Crews, Deidra C. Coresh, Josef Miller, Edgar R., III Saran, Rajiv Yee, Jerry Hedgeman, Elizabeth Paykov, Meda Eberhardt, Mark S. Williams, Desmond E. Powe, Neil R. CA CDC CKD Surveillance Team TI Prevalence of Chronic Kidney Disease in US Adults with Undiagnosed Diabetes or Prediabetes SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID GLOMERULAR-FILTRATION-RATE; NUTRITION EXAMINATION SURVEYS; COST-EFFECTIVENESS; SERUM CREATININE; NATIONAL-HEALTH; TRENDS; COMPLICATIONS; HYPERTENSION; NEPHROPATHY; MELLITUS AB Background and objectives: Prevalence of chronic kidney disease (CKD) in people with diagnosed diabetes is known to be high, but little is known about the prevalence of CKD in those with undiagnosed diabetes or prediabetes. We aimed to estimate and compare the community prevalence of CKD among people with diagnosed diabetes, undiagnosed diabetes, prediabetes, or no diabetes. Design, setting, participants, & measurements: The 1999 through 2006 National Health and Nutrition Examination Survey is a representative survey of the civilian, noninstitutionalized US population. Participants who were aged >= 20 years; responded to the diabetes questionnaire; and had fasting plasma glucose (FPG), serum creatinine, and urinary albumin-creatinine ratio measurements were included (N = 8188). Diabetes status was defined as follows: Diagnosed diabetes, self-reported provider diagnosis (n = 826); undiagnosed diabetes, FPG >= 126 mg/dl without self-reported diagnosis (n = 299); prediabetes, FPG >= 100 and <126 mg/dl (n = 2272); and no diabetes, FPG <100 mg/dl (n = 4791). Prevalence of CKD was defined by estimated GFR 15 to 59 ml/min per 1.73 m(2) or albumin-creatinine ratio >= 30 mg/g; adjustment was performed with multivariable logistic regression. Results: Fully 39.6% of people with diagnosed and 41.7% with undiagnosed diabetes had CKD; 17.7% with prediabetes and 10.6% without diabetes had CKD. Age-, gender-, and race/ethnicity-adjusted prevalence of CKD was 32.9, 24.2, 17.1, and 11.8%, for diagnosed, undiagnosed, pre-, and no diabetes, respectively. Among those with CKD, 39.1% had undiagnosed or prediabetes. Conclusions: CKD prevalence is high among people with undiagnosed diabetes and prediabetes. These individuals might benefit from interventions aimed at preventing development and/or progression of both CKD and diabetes. Clin J Am Soc Nephrol 5: 673-682, 2010. doi: 10.2215/CJN.07891109 C1 [Plantinga, Laura C.; Powe, Neil R.] San Francisco Gen Hosp, Dept Med, San Francisco, CA 94110 USA. [Plantinga, Laura C.; Powe, Neil R.] Univ Calif San Francisco, San Francisco, CA 94110 USA. [Crews, Deidra C.; Coresh, Josef; Miller, Edgar R., III] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Coresh, Josef] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Coresh, Josef] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Saran, Rajiv] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA. [Yee, Jerry] Henry Ford Hosp, Div Nephrol & Hypertens, Detroit, MI 48202 USA. [Paykov, Meda; Williams, Desmond E.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Eberhardt, Mark S.] Ctr Dis Control & Prevent, Div NHANES, Natl Ctr Hlth Stat, Hyattsville, MD USA. RP Plantinga, LC (reprint author), San Francisco Gen Hosp, Dept Med, 1001 Potrero Ave,Bldg 10,Floor 3, San Francisco, CA 94110 USA. EM plantingal@medsfgh.ucsf.edu FU Centers for Disease Control and Prevention through the Association of American Medical Colleges [U36/CCU319276]; AAMC [MM-0997-07/07, MM-1143-10/10]; [K24DK02643] FX This project was supported under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of American Medical Colleges, grant U36/CCU319276, AAMC ID nos. MM-0997-07/07 and MM-1143-10/10. Publication and report contents are solely the responsibility of the authors and do not reflect the views of the AAMC or CDC. N.R.P. is partially supported by grant K24DK02643. NR 30 TC 118 Z9 124 U1 4 U2 8 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD APR PY 2010 VL 5 IS 4 BP 673 EP 682 DI 10.2215/CJN.07891109 PG 10 WC Urology & Nephrology SC Urology & Nephrology GA 582GP UT WOS:000276585000018 PM 20338960 ER PT J AU Iwamoto, M Ayers, T Mahon, BE Swerdlow, DL AF Iwamoto, Martha Ayers, Tracy Mahon, Barbara E. Swerdlow, David L. TI Epidemiology of Seafood-Associated Infections in the United States SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Review ID VIBRIO-VULNIFICUS INFECTIONS; RAW OYSTERS; FISH CONSUMPTION; PARAHAEMOLYTICUS INFECTIONS; MULTISTATE OUTBREAK; NORWALK VIRUS; GULF-COAST; SALMONELLA; SHELLFISH; GASTROENTERITIS AB Seafood is part of a healthful diet, but seafood consumption is not risk-free. Seafood is responsible for an important proportion of food-borne illnesses and outbreaks in the United States. Seafood-associated infections are caused by a variety of bacteria, viruses, and parasites; this diverse group of pathogens results in a wide variety of clinical syndromes, each with its own epidemiology. Some seafood commodities are inherently more risky than others, owing to many factors, including the nature of the environment from which they come, their mode of feeding, the season during which they are harvested, and how they are prepared and served. Prevention of seafood-associated infections requires an understanding not only of the etiologic agents and seafood commodities associated with illness but also of the mechanisms of contamination that are amenable to control. Defining these problem areas, which relies on surveillance of seafood-associated infections through outbreak and case reporting, can lead to targeted research and help to guide control efforts. Coordinated efforts are necessary to further reduce the risk of seafood-associated illnesses. Continued surveillance will be important to assess the effectiveness of current and future prevention strategies. C1 [Iwamoto, Martha] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Zoonot & Emerging Infect, Atlanta, GA USA. [Ayers, Tracy] CDC, Div Food Borne Bacterial & Mycot Dis, Atlanta, GA 30333 USA. [Mahon, Barbara E.] Ctr Dis Control & Prevent, Enter Dis Epidemiol & Surveillance Branch, FoodNet & Outbreak Surveillance Team, Atlanta, GA USA. [Swerdlow, David L.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Iwamoto, M (reprint author), CDC, Enter Dis Epidemiol Branch, 1600 Clifton Rd NE,Mailstop D-63, Atlanta, GA 30333 USA. EM miwamoto@cdc.gov OI Ayers, Tracy/0000-0003-4140-3263 NR 68 TC 118 Z9 120 U1 3 U2 36 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD APR PY 2010 VL 23 IS 2 BP 399 EP + DI 10.1128/CMR.00059-09 PG 14 WC Microbiology SC Microbiology GA 580AH UT WOS:000276418300008 PM 20375359 ER PT J AU Kobau, R DiIorio, C Chapman, D Delvecchio, P AF Kobau, Rosemarie DiIorio, Colleen Chapman, Daniel Delvecchio, Paolo CA SAMHSA CDC Mental Illness Stigma P TI Attitudes About Mental Illness and its Treatment: Validation of a Generic Scale for Public Health Surveillance of Mental Illness Associated Stigma SO COMMUNITY MENTAL HEALTH JOURNAL LA English DT Article DE Mental illness; Stigma; Attitudes; Factor analysis ID RACIAL/ETHNIC DIFFERENCES; UNITED-STATES; HELP-SEEKING; DEPRESSION; EPILEPSY; ADULTS; DISCRIMINATION; DANGEROUSNESS; PREVALENCE; KNOWLEDGE AB The purpose of this study was to test a brief instrument to monitor the U.S. public's attitudes about mental illness. A SAMHSA and CDC-led panel reached consensus through an iterative process to identify generic, multidimensional measures to test using a representative sample of 5,251 adults. Exploratory factor analysis revealed two subscales (Negative Stereotypes [alpha = 0.66]; Recovery and Outcomes [alpha = 0.69]). Confirmatory factor analysis supported the convergent validity of the two subscales. Subscale scores differed by sex, race/ethnicity, and experience with mental illness. Inclusion of these brief subscales on existing population-based surveys can help states and others track attitudes about mental illness. C1 [Kobau, Rosemarie; Chapman, Daniel] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. [DiIorio, Colleen] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci, Atlanta, GA 30322 USA. [Delvecchio, Paolo] Ctr Mental Hlth Serv, Subst Abuse & Mental Hlth Serv Adm, Rockville, MD USA. RP Kobau, R (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway NE,Mailstop K-51, Atlanta, GA 30341 USA. EM RKobau@cdc.gov NR 70 TC 24 Z9 25 U1 2 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0010-3853 J9 COMMUNITY MENT HLT J JI Community Ment. Health J. PD APR PY 2010 VL 46 IS 2 BP 164 EP 176 DI 10.1007/s10597-009-9191-x PG 13 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 581FX UT WOS:000276508100008 PM 19330448 ER PT J AU Albrecht, SS Kuklina, EV Bansil, P Jamieson, D Whiteman, MK Kourtis, AP Posner, SF Callaghan, WM AF Albrecht, Sandra S. Kuklina, Elena V. Bansil, Pooja Jamieson, Denise Whiteman, Maura K. Kourtis, Athena P. Posner, Samuel F. Callaghan, William M. TI Diabetes Trends Among Delivery Hospitalizations in the US, 1994-2004 SO DIABETES CARE LA English DT Article ID DISCHARGE DATA; MELLITUS; POPULATION; PREVALENCE; DIAGNOSIS; WOMEN AB OBJECTIVE - To examine trends in the prevalence of diabetes among delivery hospitalizations in the U.S. and to describe the characteristics of these hospitalizations. RESEARCH DESIGN AND METHODS - Hospital discharge data from 1994 through 2004 were obtained from the Nationwide Inpatient Sample. Diagnosis codes were selected for gestational diabetes mellitus (GDM), type 1 diabetes, type 2 diabetes, and unspecified diabetes. Rates of delivery hospitalization with diabetes were calculated per 100 deliveries. RESULTS - Overall, an estimated 1,863,746 hospital delivery discharges contained a diabetes diagnosis, corresponding to a rate of 4.3 per 100 deliveries over the 11-year period. GDM accounted for the largest proportion of delivery hospitalizations with diabetes (84.7%), followed by type 1 (7%), type 2 (4.7%), and unspecified diabetes (3.6%). From 1994 to 2004, the rates for all diabetes. GDM, type 1 diabetes, and type 2 diabetes significantly increased overall and within each age-group (15-24, 25-34, and >= 35 years) (P < 0.05). The largest percent increase for all ages was among type 2 diabetes (367%). By age-group, the greatest percent increases for each diabetes type were among the two younger groups. Significant predictors of diabetes at delivery included age >= 35 years vs. 15-24 years (odds ratio 4.80 [95% CI 4.72-4.891), urban versus rural location (1.14 [1.1.1-1.17]), and Medicaid/Medicare versus other payment sources (1.29 [1.26-1.32]). CONCLUSIONS - Given the increasing prevalence of diabetes among delivery hospitalizations, particularly among younger women, it will be important to monitor trends in the pregnant population and target strategies to minimize risk for maternal/Fetal complications. C1 [Albrecht, Sandra S.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Bansil, Pooja] CONRAD, Atlanta, GA USA. [Kuklina, Elena V.] Quantell, Mchenry, MD USA. [Jamieson, Denise; Whiteman, Maura K.; Kourtis, Athena P.; Posner, Samuel F.; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Albrecht, SS (reprint author), Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. EM ssalb@umich.edu RI Whiteman, Matthew/C-6079-2009; OI Whiteman, Matthew/0000-0002-6583-6779; Posner, Samuel/0000-0003-1574-585X NR 26 TC 91 Z9 93 U1 0 U2 7 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2010 VL 33 IS 4 BP 768 EP 773 DI 10.2337/dc09-1801 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 584ZI UT WOS:000276793200018 PM 20067968 ER PT J AU Kim, C Bullard, KM Herman, WH Beckles, GL AF Kim, Catherine Bullard, Kai McKeever Herman, William H. Beckles, Gloria L. TI Association Between Iron Deficiency and A1C Levels Among Adults Without Diabetes in the National Health and Nutrition Examination Survey, 1999-2006 SO DIABETES CARE LA English DT Article ID UNITED-STATES; PREMENOPAUSAL WOMEN; PREVALENCE; HEMOGLOBIN; MELLITUS; ANEMIA; GLUCOSE; TRENDS; RISK AB OBJECTIVE Iron deficiency has been reported to elevate A1C levels apart from glycemia. We examined the influence of iron deficiency on A1C distribution among adults without diabetes. RESEARCH DESIGN AND METHODS Participants included adults without self-reported diabetes or chronic kidney disease in the National Health and Nutrition Examination Survey 1999-2006 who were aged >= 18 years of age and had complete blood counts, iron studies, and A1C levels. Iron deficiency was defined as at least two abnormalities including free erythrocyte protoporphyrin >70 mu g/dl erythrocytes, transferrin saturation <16%, or serum ferritin <= 15 mu g/l. Anemia was defined as hemoglobin <13.5 g/dl in men and <12.0 g/dl in women. RESULTS Among women = 6,666), 13.7% had iron deficiency and 4.0% had iron deficiency anemia. Whereas 316 women with iron deficiency had A1C >= 5.5%, only 32 women with iron deficiency had A1C >= 6.5%. Among men (n = 3,869), only 13 had iron deficiency and A1C >= 5.5%, and only I had iron deficiency and A1C >= 6.5%. Among women, iron deficiency was associated with a greater odds of A1C >= 5.5% (odds ratio 1.39 [95% CI 1.11-1.73]) after adjustment for age, race/ethnicity, and waist circumference but not with a greater odds of A1C >= 6.5% (0.79 [0.33-1.85]). CONCLUSIONS Iron deficiency is common among women and is associated with shifts in A1C distribution from <5.5 to >= 5.5%. Further research is needed to examine whether iron deficiency is associated with shifts at higher A1C levels. C1 [Kim, Catherine; Herman, William H.] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA. [Kim, Catherine] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA. [Bullard, Kai McKeever; Beckles, Gloria L.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Herman, William H.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA. RP Kim, C (reprint author), Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA. EM cathkim@umich.edu FU National Institute of Diabetes and Digestive and Kidney Diseases [K23-DK-071552] FX C.K. was supported by Grant K23-DK-071552 from the National Institute of Diabetes and Digestive and Kidney Diseases. NR 25 TC 69 Z9 71 U1 0 U2 5 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2010 VL 33 IS 4 BP 780 EP 785 DI 10.2337/dc09-0836 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 584ZI UT WOS:000276793200020 PM 20067959 ER PT J AU Bainbridge, KE Cheng, YJ Cowie, CC AF Bainbridge, Kathleen E. Cheng, Yiling J. Cowie, Catherine C. TI Potential Mediators of Diabetes-Related Hearing Impairment in the US Population National Health and Nutrition Examination Survey 1999-2004 SO DIABETES CARE LA English DT Article ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; MELLITUS; NEUROPATHIES; ASSOCIATION; PREVALENCE; ADULTS; EAR AB OBJECTIVE - We examined potential mediators of the reported association between diabetes and hearing impairment. RESEARCH DESIGN AND METHODS - Data come from 1,508 participants, aged 40-69 years, who completed audiometric testing during 1999-2004 in the National Health and Nutrition Examination Survey (NHANES). We defined hearing impairment as the pure-tone average >25 decibels hearing level of pure-tone thresholds at low/mid (500, 1,000, and 2,000 Hz) and high (3,000, 4,000, 6,000, and 8,000 Hz) frequencies. Using logistic regression, we examined whether controlling for vascular or neuropathic conditions, cardiovascular risk factors, glycemia, or inflammation diminished the association between diabetes and hearing impairment. RESULTS - Diabetes was associated with a 100% increased odds of low/mid-frequency hearing impairment (odds ratio 2.03 [95% CI 1.32-3.10]) and a 67% increased odds of high-frequency hearing impairment (1.67 [1.14-2.44]) in preliminary models after controlling for age, sex, race/ethnicity, education, smoking, and occupational noise exposure. Adjusting for peripheral neuropathy attenuated the association with low/mid-frequency hearing impairment (1.70 [1.02-2.82]). Adjusting for albuminuria and C-reactive protein attenuated the association with high-frequency hearing impairment (1.54 [1.02-2.32] and 1.50[1.01-2.23], respectively). Diabetes was not associated with high-frequency hearing impairment after controlling for A1C (1.09 [0.60-1.99]) but remained associated with low/mid-frequency impairment. We found no evidence suggesting that our observed relationship between diabetes and hearing impairment is due to hypertension or dyslipidemia. CONCLUSIONS - Mechanisms related to neuropathic or microvascular factors, inflammation, or hyperglycemia may be mediating the association of diabetes and hearing impairment. C1 [Bainbridge, Kathleen E.] Social & Sci Syst, Silver Spring, MD USA. [Cheng, Yiling J.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Cowie, Catherine C.] NIDDK, Bethesda, MD USA. RP Bainbridge, KE (reprint author), Social & Sci Syst, Silver Spring, MD USA. EM kbainbridge@s-3.com FU National Institute of Diabetes and Digestive and Kidney Diseases [HHSN267200700001G] FX This work was financially supported by the National Institute of Diabetes and Digestive and Kidney Diseases (HHSN267200700001G). NR 24 TC 23 Z9 25 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2010 VL 33 IS 4 BP 811 EP 816 DI 10.2337/dc09-1193 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 584ZI UT WOS:000276793200025 PM 20097782 ER PT J AU Curtis, JM Horton, ES Bahnson, J Gregg, EW Jakicic, JM Regensteiner, JG Ribisl, PM Soberman, JE Stewart, KJ Espeland, MA AF Curtis, Jeffrey M. Horton, Edward S. Bahnson, Judy Gregg, Edward W. Jakicic, John M. Regensteiner, Judith G. Ribisl, Paul M. Soberman, Judith E. Stewart, Kerry J. Espeland, Mark A. CA Look AHEAD Res Grp TI Prevalence and Predictors of Abnormal Cardiovascular Responses to Exercise Testing Among Individuals With Type 2 Diabetes The Look AHEAD (Action for Health in Diabetes) study SO DIABETES CARE LA English DT Article ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; PULSE PRESSURE; RISK-FACTORS; TREADMILL EXERCISE; CLINICAL-TRIAL; MEN; MORTALITY; CAPACITY; PERFORMANCE AB OBJECTIVE - We examined maximal graded exercise test (GXT) results in 5,783 overweight/obese men and women, aged 45-76 years, with type 2 diabetes, who were entering the Look AHEAD (Action for Health in Diabetes) study, to determine the prevalence and correlates of exercise-induced cardiac abnormalities. RESEARCH DESIGN AND METHODS - Participants underwent symptom-limited maximal GXTs. Questionnaires and physical examinations were used to determine demographic, anthropometric, metabolic, and health status predictors of abnormal GXT results, which were defined as an ST segment depression >= 1.0 mm, ventricular arrhythmia, angina pectoris, poor postexercise heart rate recovery (<22 bpm reduction 2 min after exercise), or maximal exercise capacity less than 5.0 METs. Systolic blood pressure response to exercise was examined as a continuous variable, without a threshold to define abnormality. RESULTS - Exercise-induced abnormalities were present in 1,303 (22.5%) participants, of which 693 (12.0%) consisted of impaired exercise capacity. ST segment depression occurred in 440(7-6%), abnormal heart rate recovery in 206(5.0%), angina in 63 (1.1%), and arrhythmia in 41(0.7%). Of potential predictors, only greater age was associated with increased prevalence of all abnormalities. Other predictors were associated with some, but not all, abnormalities. Systolic blood pressure response decreased with greater age, duration of diabetes, and history of cardiovascular disease. CONCLUSIONS - We found a high rate of abnormal GXT results despite careful screening for cardiovascular disease symptoms. In this cohort of overweight and obese individuals with type 2 diabetes, greater age most consistently predicted abnormal GXT. Long-term follow-up of these participants will show whether these abnormalities are clinically significant. C1 [Curtis, Jeffrey M.] NIDDKD, Diabet Epidemiol & Clin Res Sect, Phoenix, AZ USA. [Horton, Edward S.] Joslin Diabet Ctr, Boston, MA 02215 USA. [Bahnson, Judy; Espeland, Mark A.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA. [Gregg, Edward W.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Jakicic, John M.] Univ Pittsburgh, Pittsburgh, PA USA. [Regensteiner, Judith G.] Univ Colorado Denver, Sch Med, Aurora, CO USA. [Soberman, Judith E.] Univ Tennessee, Memphis, TN USA. [Stewart, Kerry J.] Johns Hopkins Univ, Baltimore, MD USA. RP Curtis, JM (reprint author), NIDDKD, Diabet Epidemiol & Clin Res Sect, Phoenix, AZ USA. EM jfcurtis@mail.nih.gov FU NCATS NIH HHS [UL1 TR000005] NR 24 TC 13 Z9 13 U1 0 U2 6 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2010 VL 33 IS 4 BP 901 EP 907 DI 10.2337/dc09-1787 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 584ZI UT WOS:000276793200042 PM 20056948 ER PT J AU Giarelli, E Wiggins, LD Rice, CE Levy, SE Kirby, RS Pinto-Martin, J Mandell, D AF Giarelli, Ellen Wiggins, Lisa D. Rice, Catherine E. Levy, Susan E. Kirby, Russell S. Pinto-Martin, Jennifer Mandell, David TI Sex differences in the evaluation and diagnosis of autism spectrum disorders among children SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Autism spectrum disorder; Children; Sex differences ID PERVASIVE DEVELOPMENTAL DISORDERS; EARLY IDENTIFICATION; CHILDHOOD AUTISM; PREVALENCE; SURVEILLANCE; DISABILITIES; CHALLENGES; INTERVIEW; SAMPLE; AGE AB Background: One of the most consistent features of the autism spectrum disorders (ASDs) is the predominance among males, with approximately four males to every female. We sought to examine sex differences among children who met case definition for ASD in a large, population-based cohort with respect to age at first developmental evaluation, age of diagnosis, influence of cognitive impairment on these outcomes, and sex-specific behavioral characteristics. Methods: We conducted a secondary analysis of data collected for a population-based study of the prevalence of ASD. The sample comprised 2,568 children born in 1994 who met the case definition of ASD as established by the Autism and Developmental Disabilities Monitoring (ADDM) Network for ASD surveillance. Children who had a history of developmental disability and behavioral features consistent with the DSM-IV-TR criteria for autistic disorder, Asperger's disorder, and Pervasive Developmental Disorder Not Otherwise Specified in existing evaluation records were classified as ASD cases via two paths: streamlined and nonstreamlined. Streamlined reviews were conducted if there was an ASD diagnosis documented in the records. Data were collected in 13 sites across the United States through the ADDM Network, funded by the Centers for Disease Control and Prevention. Results: Males constituted 81% of the sample. There were no differences by sex in average age at first evaluation or average age of diagnosis among those with an existing documented chart diagnosis of an ASD. Girls were less likely than boys to have a documented diagnosis (odds ratio [OR] = 0.76, p = .004). This analysis was adjusted for cognitive impairment status. In the logistic model, with the interaction term for sex and cognitive impairment, girls with IQ of 70 or less were less likely than boys with IQ of 70 or less to have a documented diagnosis (OR = 0.70, 95% confidence interval [CI] = 0.50-0.97, p = .035). Boys with IQ greater than 70 were less likely than boys with IQ of 70 or less to have a documented diagnosis (OR = 0.60, 95% CI = 0.49-0.74, p < .001). This finding (less likely to have a documented diagnosis) was also true for girls with IQ greater than 70 (OR = 0.45, 95% CI = 0.32-0.66, p < .001). Girls were more likely to have notations of seizure-like behavior (p < .001). Boys were more likely to have notations of hyperactivity or a short attention span and aggressive behavior (p < .01). Conclusions: Girls, especially those without cognitive impairment, may be formally identified at a later age than boys. This may delay referral for early intervention. Community education efforts should alert clinicians and parents to the potential of ASDs in boys and girls. (C) 2010 Elsevier Inc. All rights reserved. C1 [Giarelli, Ellen; Pinto-Martin, Jennifer] Univ Penn, Sch Nursing, Div Biobehav Hlth Syst, Philadelphia, PA 19104 USA. [Wiggins, Lisa D.; Rice, Catherine E.] Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Levy, Susan E.] Childrens Hosp Philadelphia, Div Child Dev Rehabil & Metab Dis, Reg Autism Ctr, Philadelphia, PA 19104 USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL 33647 USA. [Mandell, David] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Ctr Autism Res, Philadelphia, PA 19104 USA. [Kirby, Russell S.] Univ Alabama, Birmingham, AL USA. EM giarelli@nursing.upenn.edu RI Mandell, David/H-2730-2012; Rice, Catherine/D-6305-2016 OI Mandell, David/0000-0001-8240-820X; FU Centers for Disease Control and Prevention (CDC) FX The authors of this manuscript were principal investigators or co-investigators participating in the ADDM Network Surveillance Project. The principal investigators and co-investigators received salary support over several years during the collection of data that was provided by the Centers for Disease Control and Prevention (CDC). There are no conflicts of interest, financial or otherwise, relevant to the subject matter of the manuscript that have occurred over the last 2 years or that are expected in the foreseeable future, beyond participation in the ADDM network. These projects were funded by the CDC. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC. For additional information, see www.cdc.gov/autism. NR 38 TC 73 Z9 74 U1 3 U2 35 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 J9 DISABIL HEALTH J JI Disabil. Health J. PD APR PY 2010 VL 3 IS 2 BP 107 EP 116 DI 10.1016/j.dhjo.2009.07.001 PG 10 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA 668QO UT WOS:000283284900007 PM 21122776 ER PT J AU Zilberberg, MD Tillotson, GS McDonald, LC AF Zilberberg, Marya D. Tillotson, Glenn S. McDonald, L. Clifford TI Clostridium difficile Infections among Hospitalized Children, United States, 1997-2006 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID DISEASE; INCREASE; DIARRHEA; SURVEILLANCE; MORTALITY; EPIDEMIC; OUTBREAK; COHORT; STRAIN AB We evaluated the annual rate (cases/10,000 hospitalizations) of pediatric hospitalizations with Clostridium difficile infection (CDI; International Classification of Diseases, 9th revision, clinical modification code 008.45) in the United States. We performed a time-series analysis of data from the Kids' Inpatient Database within the Health Care Cost and Utilization Project during 1997-2006 and a cross-sectional analysis within the National Hospital Discharge Survey during 2006. The rate of pediatric CDI-related hospitalizations increased from 7.24 to 12.80 from 1997 through 2006; the lowest rate was for children <1 year of age. Although incidence was lowest for newborns (0.5), incidence for children <1 year of age who were not newborns (32.01) was similar to that for children 5-9 years of age (35.27), which in turn was second only to incidence for children 1-4 years of age (44.87). Pediatric CDI-related hospitalizations are increasing. A better understanding of the epidemiology and outcomes of CDI is urgently needed. C1 [Zilberberg, Marya D.] EviMed Res Grp LLC, Goshen, MA 01032 USA. [Zilberberg, Marya D.] Univ Massachusetts, Amherst, MA 01003 USA. [Tillotson, Glenn S.] ViroPharma Inc, Exton, PA USA. [McDonald, L. Clifford] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Zilberberg, MD (reprint author), EviMed Res Grp LLC, POB 303, Goshen, MA 01032 USA. EM marya@evimedgroup.org FU ViroPharma Inc. FX M.D.Z. was supported by a grant from ViroPharma Inc. NR 26 TC 108 Z9 114 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 604 EP 609 DI 10.3201/eid1604.090680 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400003 PM 20350373 ER PT J AU Jenke, C Harmsen, D Weniger, T Rothganger, J Hyytia-Trees, E Bielaszewska, M Karch, H Mellmann, A AF Jenke, Christian Harmsen, Dag Weniger, Thomas Rothgaenger, Joerg Hyytia-Trees, Eija Bielaszewska, Martina Karch, Helge Mellmann, Alexander TI Phylogenetic Analysis of Enterohemorrhagic Escherichia coli O157, Germany, 1987-2008 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TANDEM REPEAT ANALYSIS; MULTILOCUS VARIABLE-NUMBER; FIELD GEL-ELECTROPHORESIS; HEMOLYTIC-UREMIC SYNDROME; COLI O157-H7; MYCOBACTERIUM-TUBERCULOSIS; STAPHYLOCOCCUS-AUREUS; POPULATION-STRUCTURE; PATHOGENIC BACTERIA; EVOLUTION AB Multi locus variable number tandem repeat analysis (MLVA) is a subtyping technique for characterizing human pathogenic bacteria such as enterohemorrhagic Escherichia coli (EHEC) O157. We determined the phylogeny of 202 epidemiologically unrelated EHEC O157:H7/H- clinical isolates through 8 MLVA loci obtained in Germany during 1987-2008. Biodiversity in the loci ranged from 0.66 to 0.90. Four of 8 loci showed null alleles and a frequency <= 44.1%. These loci were distributed among 48.5% of all strains. Overall, 141 MLVA profiles were identified. Phylogenetic analysis assigned 67.3% of the strains to 19 MLVA clusters. Specific MLVA profiles with an evolutionary persistence were identified, particularly within sorbitol-fermenting EHEC O157:H-. These pathogens belonged to the same MLVA cluster. Our findings indicate successful persistence of this clone. C1 [Jenke, Christian; Bielaszewska, Martina; Karch, Helge; Mellmann, Alexander] Univ Klinikum Munster, Inst Hyg, D-48149 Munster, Germany. [Harmsen, Dag; Weniger, Thomas] Dept Periodontol, Munster, Germany. [Rothgaenger, Joerg] Ridom GmbH, Wurzburg, Germany. [Hyytia-Trees, Eija] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Mellmann, A (reprint author), Univ Klinikum Munster, Inst Hyg, Robert Koch Str 41, D-48149 Munster, Germany. EM mellmann@uni-muenster.de RI Harmsen, Dag/J-3041-2012; OI Mellmann, Alexander/0000-0002-0649-5185 FU German Federal Ministry of Education and Research [0315219A] FX This study was supported by a grant from the German Federal Ministry of Education and Research (0315219A). NR 40 TC 14 Z9 14 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 610 EP 616 DI 10.3201/eid1604.091361 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400004 PM 20350374 ER PT J AU Morgan, OW Parks, S Shim, T Blevins, PA Lucas, PM Sanchez, R Walea, N Loustalot, F Duffy, MR Shim, MJ Guerra, S Guerra, F Mills, G Verani, J Alsip, B Lindstrom, S Shu, B Emery, S Cohen, AL Menon, M Fry, AM Dawood, F Fonseca, VP Olsen, SJ AF Morgan, Oliver W. Parks, Sharyn Shim, Trudi Blevins, Patricia A. Lucas, Pauline M. Sanchez, Roger Walea, Nancy Loustalot, Fleetwood Duffy, Mark R. Shim, Matthew J. Guerra, Sandra Guerra, Fernando Mills, Gwen Verani, Jennifer Alsip, Bryan Lindstrom, Stephen Shu, Bo Emery, Shannon Cohen, Adam L. Menon, Manoj Fry, Alicia M. Dawood, Fatimah Fonseca, Vincent P. Olsen, Sonja J. TI Household Transmission of Pandemic (H1N1) 2009, San Antonio, Texas, USA, April-May 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID INFLUENZA-VIRUS INFECTIONS; SEATTLE FAMILIES; AGE; VACCINATION; PROPHYLAXIS; OSELTAMIVIR; PREVENTION; ZANAMIVIR; VACCINES; ANTIBODY AB To assess household transmission of pandemic (H1N1) 2009 in San Antonio, Texas, USA, during April 15 May 8, 2009, we investigated 77 households. The index case-patient was defined as the household member with the earliest onset date of symptoms of acute respiratory infection (ARI), influenza-like illness (ILI), or laboratory-confirmed pandemic (H1N1) 2009. Median interval between illness onset in index and secondary case-patients was 4 days (range 1-9 days); the index case-patient was likely to be <= 18 years of age (p = 0.034). The secondary attack rate was 4% for pandemic (H1N1) 2009, 9% for ILI, and 13% for ARI. The secondary attack rate was highest for children <5 years of age (8%-19%) and lowest for adults >= 50 years of age (4%-12%). Early in the outbreak, household transmission primarily occurred from children to other household members and was lower than the transmission rate for seasonal influenza. C1 [Morgan, Oliver W.; Parks, Sharyn; Loustalot, Fleetwood; Verani, Jennifer; Lindstrom, Stephen; Shu, Bo; Emery, Shannon; Cohen, Adam L.; Menon, Manoj; Fry, Alicia M.; Dawood, Fatimah; Olsen, Sonja J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Parks, Sharyn; Shim, Trudi; Walea, Nancy; Guerra, Fernando; Fonseca, Vincent P.] Dept State Hlth Serv, Austin, TX USA. [Lucas, Pauline M.; Duffy, Mark R.; Shim, Matthew J.] USAF, Sch Aerosp Med, Brooks City Base, TX USA. [Blevins, Patricia A.; Sanchez, Roger; Guerra, Fernando; Alsip, Bryan] San Antonio Metropolitan Hlth Dist, San Antonio, TX USA. [Mills, Gwen] Comal Cty Hlth Dept, New Braunfels, TX USA. RP Morgan, OW (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop C12, Atlanta, GA 30333 USA. EM omorgan@cdc.gov NR 27 TC 46 Z9 48 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 631 EP 637 DI 10.3201/eid1604.091658 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400007 PM 20350377 ER PT J AU Hall, AJ Cassiday, PK Bernard, KA Bolt, F Steigerwalt, AG Bixler, D Pawloski, LC Whitney, AM Iwaki, M Baldwin, A Dowson, CG Komiya, T Takahashi, M Hinrikson, HP Tondella, ML AF Hall, Aron J. Cassiday, Pamela K. Bernard, Kathryn A. Bolt, Frances Steigerwalt, Arnold G. Bixler, Danae Pawloski, Lucia C. Whitney, Anne M. Iwaki, Masaaki Baldwin, Adam Dowson, Christopher G. Komiya, Takako Takahashi, Motohide Hinrikson, Hans P. Tondella, Maria L. TI Novel Corynebacterium diphtheriae in Domestic Cats SO EMERGING INFECTIOUS DISEASES LA English DT Article ID REAL-TIME PCR; ULCERANS STRAINS; IDENTIFICATION; TOXIN; GENE AB Novel nontoxigenic Cotynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic transmission was identified. Molecular methods distinguished the feline isolates from known C. diphtheriae. C1 [Hall, Aron J.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Hall, Aron J.; Bixler, Danae] W Virginia Dept Hlth & Human Resources, Charleston, WV USA. [Bernard, Kathryn A.] Publ Hlth Agcy Canada, Winnipeg, MB, Canada. [Bolt, Frances; Baldwin, Adam; Dowson, Christopher G.] Univ Warwick, Coventry CV4 7AL, W Midlands, England. [Iwaki, Masaaki; Komiya, Takako; Takahashi, Motohide] Natl Inst Infect Dis, Tokyo, Japan. RP Hall, AJ (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd NE,Maistop A47, Atlanta, GA 30333 USA. EM ajhall@cdc.gov OI Dowson, Christopher/0000-0002-8294-8836 FU Biotechnology and Biological Sciences Research Council; Micropathology Ltd; Medical Research Fund FX Work performed at University of Warwick was funded in part by the Biotechnology and Biological Sciences Research Council, Micropathology Ltd, and the Medical Research Fund. NR 15 TC 21 Z9 23 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 688 EP 691 DI 10.3201/eid1604.091107 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400018 PM 20350389 ER PT J AU Bhengsri, S Baggett, HC Peruski, LF Morway, C Bai, Y Fisk, TL Sitdhirasdr, A Maloney, SA Dowell, SF Kosoy, M AF Bhengsri, Saithip Baggett, Henry C. Peruski, Leonard F., Jr. Morway, Christina Bai, Ying Fisk, Tamara L. Sitdhirasdr, Anussorn Maloney, Susan A. Dowell, Scott F. Kosoy, Michael TI Bartonella spp. Infections, Thailand SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID HENSELAE; PREVALENCE; DIVERSITY; RODENTS C1 [Bhengsri, Saithip] US Ctr Dis Control & Prevent Collaborat, Int Emerging Infect Program, Thailand Minist Publ Hlth, Minist Publ Hlth,Dept Dis Control, Nonthaburi 11000, Thailand. [Dowell, Scott F.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Morway, Christina; Bai, Ying; Kosoy, Michael] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Bhengsri, S (reprint author), US Ctr Dis Control & Prevent Collaborat, Int Emerging Infect Program, Thailand Minist Publ Hlth, Minist Publ Hlth,Dept Dis Control, 3rd Floor,Bldg 7, Nonthaburi 11000, Thailand. EM saithipb@th.cdc.gov NR 8 TC 9 Z9 9 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 743 EP 745 DI 10.3201/eid1604.090699 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400043 PM 20350414 ER PT J AU Potter, P AF Potter, Polyxeni TI A Clean, Well-Lighted Place SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM PMP1@cdc.gov NR 8 TC 0 Z9 0 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2010 VL 16 IS 4 BP 751 EP 752 DI 10.3201/eid1604.000000 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 580UQ UT WOS:000276476400049 ER PT J AU Lopez-Carrillo, L Hernandez-Ramirez, RU Calafat, AM Torres-Sanchez, L Galvan-Portillo, M Needham, LL Ruiz-Ramos, R Cebrian, ME AF Lopez-Carrillo, Lizbeth Hernandez-Ramirez, Raul U. Calafat, Antonia M. Torres-Sanchez, Luisa Galvan-Portillo, Marcia Needham, Larry L. Ruiz-Ramos, Ruben Cebrian, Mariano E. TI Exposure to Phthalates and Breast Cancer Risk in Northern Mexico SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE breast cancer; case-control study; endocrine disruptors; environment; Mexico; phthalates; risk assessment; urinary metabolites ID ACTIVATED-RECEPTOR-GAMMA; HIGH PLASMA-CONCENTRATIONS; BODY TOPICAL APPLICATION; THYROID-HORMONE LEVELS; DIETHYL PHTHALATE; PREGNANT-WOMEN; COMET ASSAY; HUMAN SPERM; DNA-DAMAGE; PPAR-GAMMA AB BACKGROUND: Phthalates, ubiquitous environmental pollutants that may disturb the endocrine system, are used primarily as plasticizers of polyvinyl chloride and as additives in consumer and personal care products. OBJECTIVES: In this study, we examined the association between urinary concentrations of nine phthalate metabolites and breast cancer (BC) in Mexican women. METHODS: We age-matched 233 BC cases to 221 women residing in northern Mexico. Sociodemographic and reproductive characteristics were obtained by direct interviews. Phthalates were determined in urine samples (collected pretreatment from the cases) by isotope dilution/high-performance liquid chromatography coupled to tandem mass spectrometry. RESULTS: Phthalate metabolites were detected in at least 82% of women. The geometric mean concentrations of monoethyl phthalate (MEP) were higher in cases than in controls (169.58 vs. 106.78 mu g/g creatinine). Controls showed significantly higher concentrations of mono-n-butyl phthalate, mono(2-ethyl-5-oxohexyl) phthalate, and mono(3-carboxypropyl) phthalate (MCPP) than did the cases. After adjusting for risk factors and other phthalates, MEP urinary concentrations were positively associated with BC [odds ratio (OR), highest vs. lowest tertile = 2.20; 95% confidence interval (CI), 1.33-3.63; p for trend < 0.01]. This association became stronger when estimated for premenopausal women (OR, highest vs. lowest tertile = 4.13; 95% CI, 1.60-10.70; p for trend < 0.01). In contrast, we observed significant negative associations for monobenzyl phthalate (MBzP) and MCPP. CONCLUSIONS: We show for the first time that exposure to diethyl phthalate, the parent compound of MEP, may be associated with increased risk of BC, whereas exposure to the parent phthalates of MBzP and MCPP might be negatively associated. These findings require confirmation. C1 [Lopez-Carrillo, Lizbeth; Hernandez-Ramirez, Raul U.; Torres-Sanchez, Luisa; Galvan-Portillo, Marcia] Natl Inst Publ Hlth, Cuernavaca 62100, Morelos, Mexico. [Calafat, Antonia M.; Needham, Larry L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Ruiz-Ramos, Ruben; Cebrian, Mariano E.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Toxicol, Mexico City, DF, Mexico. RP Lopez-Carrillo, L (reprint author), Natl Inst Publ Hlth, Univ 655, Cuernavaca 62100, Morelos, Mexico. EM lizbeth@insp.mx RI Needham, Larry/E-4930-2011 FU CONACYT (Consejo Nacional de Ciencia y Tecnologia) Fondo Sectorial de Investigacion en Salud y Seguridad Social (FOSISS) [2005-C02-14373, FOSISS 2009-01-11384, SEP-CONACYT 2008-79912] FX The study was supported by CONACYT (Consejo Nacional de Ciencia y Tecnologia) Fondo Sectorial de Investigacion en Salud y Seguridad Social (FOSISS) 2005-C02-14373, FOSISS 2009-01-11384, and SEP-CONACYT 2008-79912. NR 54 TC 99 Z9 100 U1 10 U2 44 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2010 VL 118 IS 4 BP 539 EP 544 DI 10.1289/ehp.0901091 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 580NA UT WOS:000276454800028 PM 20368132 ER PT J AU Engel, SM Miodovnik, A Canfield, RL Zhu, CB Silva, MJ Calafat, AM Wolff, MS AF Engel, Stephanie M. Miodovnik, Amir Canfield, Richard L. Zhu, Chenbo Silva, Manori J. Calafat, Antonia M. Wolff, Mary S. TI Prenatal Phthalate Exposure Is Associated with Childhood Behavior and Executive Functioning SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE attention deficit hyperactivity disorder; BASC; BRIEF; environmental exposure; phthalate ID PREGNANT-WOMEN; DI(2-ETHYLHEXYL) PHTHALATE; TEMPORAL VARIABILITY; ASSESSMENT SCALE; METABOLITES; PERFORMANCE; DISORDER; CHILDREN; COHORT; RATS AB BACKGROUND: Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment. OBJECTIVE:: Our goal was to examine the association of prenatal phthalate exposure with behavior and executive functioning at 4-9 years of age. METHODS: The Mount Sinai Children's Environmental Health Study enrolled a multiethnic prenatal population in New York City between 1998 and 2002 (n = 404). Third-trimester maternal urines were collected and analyzed for phthalate metabolites. Children (n = 188, n = 365 visits) were assessed for cognitive and behavioral development between the ages of 4 and 9 years. RESULTS: In multivariate adjusted models, increased log(e) concentrations of low molecular weight (LMW) phthalate metabolites were associated with poorer scores on the aggression [beta = 1.24; 95% confidence interval (CI), 0.15 2.34], conduct problems (beta = 2.40; 95% CI, 1.34-3.46), attention problems (beta = 1.29; 95% CI, 0.16-2.41), and depression (beta = 1.18; 95% CI, 0.11-2.24) clinical scales; and externalizing problems (beta = 1.75; 95% CI, 0.61-2.88) and behavioral symptom index (beta = 1.55; 95% CI, 0.39-2.71) composite scales. Increased log concentrations of LMW phthalates were also associated with poorer scores on the global executive composite index (beta = 1.23; 95% CI, 0.09-2.36) and the emotional control scale (beta = 1.33; 95% CI, 0.18-2.49). CONCLUSION: Behavioral domains adversely associated with prenatal exposure to LMW phthalates in our study are commonly found to be affected in children clinically diagnosed with conduct or attention deficit hyperactivity disorders. C1 [Engel, Stephanie M.; Miodovnik, Amir; Zhu, Chenbo; Wolff, Mary S.] Mt Sinai Sch Med, Dept Prevent Med, New York, NY 10029 USA. [Canfield, Richard L.] Cornell Univ, Coll Human Ecol, Div Nutr Sci, Ithaca, NY USA. [Silva, Manori J.; Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Engel, SM (reprint author), Mt Sinai Sch Med, Dept Prevent Med, 1 Gustave L Levy Pl,Box 1057, New York, NY 10029 USA. EM stephanie.engel@mssm.edu FU NICHD NIH HHS [5T32HD049311, T32 HD049311]; NIEHS NIH HHS [P01 ES009584, ES09584]; PHS HHS [R827039] NR 34 TC 162 Z9 171 U1 13 U2 57 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2010 VL 118 IS 4 BP 565 EP 571 DI 10.1289/ehp.0901470 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 580NA UT WOS:000276454800032 PM 20106747 ER PT J AU Windham, GC Pinney, SM Sjodin, A Lum, R Jones, RS Needham, LL Biro, FM Hiatt, RA Kushi, LH AF Windham, Gayle C. Pinney, Susan M. Sjodin, Andreas Lum, Raymond Jones, Richard S. Needham, Larry L. Biro, Frank M. Hiatt, Robert A. Kushi, Lawrence H. TI Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls SO ENVIRONMENTAL RESEARCH LA English DT Article DE Biomarkers; PBDEs; PCBs; Pesticides; Puberty; Children ID POLYBROMINATED DIPHENYL ETHERS; POLYCHLORINATED BIPHENYL LEVELS; EXPOSED IN-UTERO; SERUM CONCENTRATIONS; TEMPORAL TRENDS; PREGNANT-WOMEN; UNITED-STATES; DICHLORODIPHENYL DICHLOROETHENE; CHILDHOOD GROWTH; YOUNG GIRLS AB Background: Levels of brominated flame retardants are increasing in US populations, yet little data are available on body burdens of these and other persistent hormonally active agents (HAAs) in school-aged children. Exposures to such chemicals may affect a number of health outcomes related to development and reproductive function. Objective: Determine the distribution of biomarkers of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organo-chlorinated pesticides (OCPs), such as DDT/DDE, in children, and their variation by key descriptor variables. Methods: Ethnically diverse cohorts of girls 6-8 y old at baseline are being followed for growth and pubertal development in a multi-site, longitudinal study. Nearly 600 serum samples from the California and Ohio sites were analyzed for lipids, 35 PCB congeners, 11 PBDE congeners, and 9 OCPs. The biomarker distributions were examined and geometric means compared for selected analytes across categories of age, race, site, body mass index (BMI), parental education, maternal age at delivery, and breast feeding in adjusted models. Results: Six PBDE congeners were detected among greater than 70% of samples, with BDE-47 having the highest concentration (median 42.2, range 4.9-855 ng/g lipid). Girls in California had adjusted geometric mean (GM) PBDE levels significantly higher than girls in Ohio. Furthermore, Blacks had significantly higher adjusted GMs of all six PBDE congeners than Whites, and Hispanics had intermediate values. GMs tended to be lower among more obese girls, while other variables were not strongly associated. In contrast, GMs of the six PCB congeners most frequently detected were significantly lower among Blacks and Hispanics than Whites. PCBs and the three pesticides most frequently detected were also consistently lower among girls with high BMI, who were not breast-fed, whose mothers were younger, or whose care-givers (usually parents) were less educated. Girls in California had higher GMs than in Ohio for the pesticides and most PCB congeners, but the opposite for CB-99 and -118. Conclusions: Several of these potential HAAs were detected in nearly all of these young girls, some at relatively high levels, with variation by geographic location and other demographic factors that may reflect exposure pathways. The higher PBDE levels in California likely reflect differences in fire regulation and safety codes, with potential policy implications. (C) 2010 Elsevier Inc. All rights reserved. C1 [Windham, Gayle C.] DEODC, CA Dept Publ Hlth, Richmond, CA 94804 USA. [Pinney, Susan M.; Biro, Frank M.] Univ Cincinnati, Coll Med, Cincinnati, OH 45267 USA. [Sjodin, Andreas; Jones, Richard S.; Needham, Larry L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Lum, Raymond] Impact Assessment Inc, San Diego, CA USA. [Hiatt, Robert A.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Kushi, Lawrence H.] Kaiser Permanente No Calif, Oakland, CA 94612 USA. RP Windham, GC (reprint author), DEODC, CA Dept Publ Hlth, 850 Marina Bay Pkwy,Bldg P, Richmond, CA 94804 USA. EM gayle.windham@cdph.ca.gov RI Needham, Larry/E-4930-2011; Sjodin, Andreas/F-2464-2010; OI Kushi, Lawrence/0000-0001-9136-1175 FU National Institute of Environmental Health Sciences (NIEHS); National Cancer Institute (NCI), NIH, DHHS [U01 ES012801, U01 ES12770]; University of Cincinnati Center for Environmental Genetics [P30-ES006096]; CA Department of Public Health (CDPH); NIH/NCRR [UL1 RR024131] FX This work was funded by the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI), NIH, DHHS to the Breast Cancer & the Environment Research Centers at the University of California San Francisco Helen Diller Family Comprehensive Cancer Center (U01 ES012801) and the University of Cincinnati/Cincinnati Children's Hospital Medical Center (U01 ES12770), with support from the University of Cincinnati Center for Environmental Genetics (P30-ES006096), the CA Department of Public Health (CDPH), and the NIH/NCRR-sponsored UCSF Center for Translational Science Institute (UL1 RR024131). The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, the NCI, the CDC, or the CDPH. Before initiation of the study, human subjects approval was obtained from the IRBs of the institutions carrying out subject recruitment and data collection, e.g. Kaiser Permanente, Northern California (no.: CN-04LKush-04-H. last re-approved on 14 October 2008) and the University of Cincinnati (CCHMC IRB no. 03-18-05, last re-approved on I November 2008). NR 41 TC 43 Z9 45 U1 2 U2 25 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD APR PY 2010 VL 110 IS 3 BP 251 EP 257 DI 10.1016/j.envres.2010.01.004 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 573VL UT WOS:000275943300007 PM 20129604 ER PT J AU Akinbami, LJ Lynch, CD Parker, JD Woodruff, TJ AF Akinbami, Lara J. Lynch, Courtney D. Parker, Jennifer D. Woodruff, Tracey J. TI The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004 SO ENVIRONMENTAL RESEARCH LA English DT Article DE Asthma; Air pollution; Children; Epidemiology; Public health ID RESPIRATORY HEALTH; MEDICATION USE; AMERICAN CHILDREN; SYMPTOM SEVERITY; SCHOOL-CHILDREN; OZONE EXPOSURE; CASE-CROSSOVER; LUNG-FUNCTION; POLLUTION; PARTICLES AB Background: Air pollution exposure has been linked to adverse respiratory health outcomes among children, primarily in studies of acute exposures that are often in limited geographic areas. We sought to assess the association between chronic outdoor air pollution exposure, as measured by 12-month averages by county, and asthma among children in metropolitan areas across the nation. Methods: Eligible children included those aged 3-17 years residing in US metropolitan areas who were sampled in the 2001-2004 National Health Interview Survey (N=34,073). 12-month average air pollutant levels for sulfur dioxide, nitrogen dioxide, ozone and particulate matter were compiled by county for 2000-2004. Eligible children were linked to pollutant levels for the previous 12 months for their county of residence. Adjusted odds ratios of having current asthma or an asthma attack in the past 12 months were estimated in single pollutant logistic regression models. Results: Children in counties with ozone and, to a less consistent degree, particulate matter levels in the highest quartile were more likely to have current asthma and/or a recent asthma attack than children residing in counties with the lowest pollution levels; the adjusted odds for current asthma for the highest quartile of estimated ozone exposure was 1.56 (95% confidence interval [Cl]: 1.15, 2.10) and for recent asthma attack 1.38 (95% Cl: 0.99, 1.91). No associations were found with sulfur dioxide or nitrogen dioxide levels. Conclusion: Although the current US standard for ozone is based on short-term exposure, this cross-sectional study suggests that chronic (12-month) exposure to ozone and particles is related to asthma outcomes among children in metropolitan areas throughout the US. Published by Elsevier Inc. C1 [Akinbami, Lara J.; Parker, Jennifer D.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Akinbami, Lara J.] US PHS, Rockville, MD USA. [Lynch, Courtney D.] Ohio State Univ, Coll Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA. [Woodruff, Tracey J.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Oakland, CA USA. RP Akinbami, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM lea8@cdc.gov RI Osborne, Nicholas/N-4915-2015 OI Osborne, Nicholas/0000-0002-6700-2284 FU EPA [68-W-02-040] FX The calculation of 12-month quarterly moving averages of air pollutant concentrations by county was funded by EPA Contract no. 68-W-02-040. NR 51 TC 47 Z9 48 U1 0 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD APR PY 2010 VL 110 IS 3 BP 294 EP 301 DI 10.1016/j.envres.2010.01.001 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 573VL UT WOS:000275943300013 PM 20117766 ER PT J AU Daly, ER Roy, SJ Blaney, DD Manning, JS Hill, VR Xiao, L Stull, JW AF Daly, E. R. Roy, S. J. Blaney, D. D. Manning, J. S. Hill, V. R. Xiao, L. Stull, J. W. TI Outbreak of giardiasis associated with a community drinking-water source SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Drinking water; Giardia; groundwater; outbreak ID CRYPTOSPORIDIUM SPP.; CASTOR-CANADENSIS; RISK-FACTORS; DUODENALIS; TRANSMISSION; PREVALENCE; INFECTION; GENOTYPES; RESERVOIR; CANADA AB Giardiasis is a common waterborne gastrointestinal illness. In 2007, a community giardiasis outbreak occurred in New Hampshire, USA. We conducted a cohort study to identify risk factors for giardiasis, and stool and environmental samples were analysed. Consuming tap water was significantly associated with illness (risk ratio 4.7, 95% confidence interval 1.5-14.4). Drinking-water samples were coliform-contaminated and a suspect Giardia cyst was identified in a home water filter. One well was coliform-contaminated. and testing, indicated that it was potentially under the influence of surface water. The well was located 12.5 m from a Giardia-contaminated brook, although the genotype differed from clinical specimens. Local water regulations require well placement at least 15 m from surface water. This outbreak, which caused illness in 31 persons, represents the largest community drinking-water-associated giardiasis outbreak in the USA in 10 years. Adherence to well placement regulations might have prevented this outbreak. C1 [Daly, E. R.] New Hampshire Dept Hlth & Human Serv, Communicable Dis Surveillance Sect, Concord, NH 03301 USA. [Roy, S. J.] New Hampshire Dept Environm Serv, Concord, NH USA. [Blaney, D. D.; Hill, V. R.; Xiao, L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Stull, J. W.] Univ New Hampshire, Durham, NH 03824 USA. RP Daly, ER (reprint author), New Hampshire Dept Hlth & Human Serv, Communicable Dis Surveillance Sect, 29 Hazen Dr, Concord, NH 03301 USA. EM erdaly@dhhs.state.nh.us RI Hill, Vincent/G-1789-2012; Xiao, Lihua/B-1704-2013; Stull, Jason/A-8816-2013 OI Hill, Vincent/0000-0001-7069-7737; Xiao, Lihua/0000-0001-8532-2727; NR 34 TC 18 Z9 22 U1 0 U2 14 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD APR PY 2010 VL 138 IS 4 BP 491 EP 500 DI 10.1017/S0950268809990744 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 578GE UT WOS:000276280800005 PM 19751538 ER PT J AU Lott, TJ Frade, JP Lockhart, SR AF Lott, Timothy J. Frade, Joao P. Lockhart, Shawn R. TI Multilocus Sequence Type Analysis Reveals both Clonality and Recombination in Populations of Candida glabrata Bloodstream Isolates from US Surveillance Studies SO EUKARYOTIC CELL LA English DT Article ID ACTIVE SURVEILLANCE; UNITED-STATES; EPIDEMIOLOGY; INFECTIONS; SUSCEPTIBILITIES AB The human commensal yeast Candida glabrata is becoming increasingly important as an agent of nosocomial bloodstream infection. However, relatively little is known concerning the genetics and population structure of this species. We have analyzed 230 incident bloodstream isolates from previous and current population-based surveillance studies by using multilocus sequence typing (MLST). Our results show that in the U. S. cities of Atlanta, GA; Baltimore, MD; and San Francisco, CA during three time periods spanning 1992 to 2009, five populations of C. glabrata bloodstream isolates are defined by a relatively small number of sequence types. There is little genetic differentiation in the different C. glabrata populations. We also show that there has been a significant temporal shift in the prevalence of one major subtype in Atlanta. Our results support the concept that both recombination and clonality play a role in the population structure of this species. C1 [Lott, Timothy J.; Frade, Joao P.; Lockhart, Shawn R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. RP Lockhart, SR (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,Mailstop G-11, Atlanta, GA 30333 USA. EM gyi2@cdc.gov NR 24 TC 19 Z9 22 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1535-9778 J9 EUKARYOT CELL JI Eukaryot. Cell PD APR PY 2010 VL 9 IS 4 BP 619 EP 625 DI 10.1128/EC.00002-10 PG 7 WC Microbiology; Mycology SC Microbiology; Mycology GA 579KR UT WOS:000276369600014 PM 20190071 ER PT J AU Moonesinghe, R Liu, TB Khoury, MJ AF Moonesinghe, Ramal Liu, Tiebin Khoury, Muin J. TI Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases SO EUROPEAN JOURNAL OF HUMAN GENETICS LA English DT Article DE genomic profiles; discriminative accuracy; heritability ID BINARY VARIABLES; RISK; INTERVENTIONS; ASSOCIATION; METHODOLOGY; CANCER AB Genetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the discriminative accuracy increases with increasing heritability but declines with increasing prevalence of the disease. For a given value of population-attributable fraction, the discriminative accuracy increases with increasing relative risks, but declines with increasing genotype frequency. On the basis of population-attributable fraction and estimates of heritability of disease, the number of risk genotypes required to have a reasonable clinical discriminative accuracy is much higher than the genome profiles available at present. European Journal of Human Genetics (2010) 18, 485-489; doi:10.1038/ejhg.2009.209; published online 25 November 2009 C1 [Moonesinghe, Ramal] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA 30333 USA. [Liu, Tiebin; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. RP Moonesinghe, R (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Mailstop E-67,1600 Clifton Rd,NE, Atlanta, GA 30333 USA. EM rmoonesinghe@cdc.gov NR 22 TC 15 Z9 15 U1 1 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1018-4813 EI 1476-5438 J9 EUR J HUM GENET JI Eur. J. Hum. Genet. PD APR PY 2010 VL 18 IS 4 BP 485 EP 489 DI 10.1038/ejhg.2009.209 PG 5 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA 571CF UT WOS:000275726900018 PM 19935832 ER PT J AU Eaton, DK Brener, ND Kann, L Denniston, MM McManus, T Kyle, TM Roberts, AM Flint, KH Ross, JG AF Eaton, Danice K. Brener, Nancy D. Kann, Laura Denniston, Maxine M. McManus, Tim Kyle, Tonja M. Roberts, Alice M. Flint, Katherine H. Ross, James G. TI Comparison of Paper-and-Pencil Versus Web Administration of the Youth Risk Behavior Survey (YRBS): Risk Behavior Prevalence Estimates SO EVALUATION REVIEW LA English DT Article DE survey research methodology; survey mode; risk behavior; adolescent ID HIGH-SCHOOL-STUDENTS; DRUG-USE; SUBSTANCE USE; COMPUTER; HEALTH; QUESTIONNAIRES; ALCOHOL; TOBACCO; MODE; IMPACT AB The authors examined whether paper-and-pencil and Web surveys administered in the school setting yield equivalent risk behavior prevalence estimates. Data were from a methods study conducted by the Centers for Disease Control and Prevention (CDC) in spring 2008. Intact classes of 9th- or 10th-grade students were assigned randomly to complete a survey via paper-and-pencil or Web. Data from 5,227 students were analyzed using logistic regression to identify associations of mode with reporting of 74 risk behaviors. Mode was associated with reporting of only 7 of the 74 risk behaviors. Results indicate prevalence estimates from paper-and-pencil and Web school-based surveys are generally equivalent. C1 [Eaton, Danice K.; Brener, Nancy D.; Kann, Laura; Denniston, Maxine M.; McManus, Tim] Ctr Dis Control & Prevent, Div Adolescent, Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Eaton, Danice K.; Brener, Nancy D.; Kann, Laura; Denniston, Maxine M.; McManus, Tim] Ctr Dis Control & Prevent, Sch Hlth, Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Kyle, Tonja M.; Roberts, Alice M.; Flint, Katherine H.; Ross, James G.] ICF Macro Inc, Calverton, MD USA. RP Eaton, DK (reprint author), Ctr Dis Control & Prevent, Div Adolescent, Ctr Chron Dis Prevent & Hlth Promot, Mailstop K-33,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM dhe0@cdc.gov NR 21 TC 18 Z9 18 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0193-841X J9 EVALUATION REV JI Eval. Rev. PD APR PY 2010 VL 34 IS 2 BP 137 EP 153 DI 10.1177/0193841X10362491 PG 17 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 570JR UT WOS:000275671400003 PM 20234000 ER PT J AU Kachur, SP MacArthur, JR Slutsker, L AF Kachur, Stephen P. MacArthur, John R. Slutsker, Laurence TI A call to action: addressing the challenge of artemisinin-resistant malaria SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Editorial Material ID PLASMODIUM-FALCIPARUM; IMPACT C1 [Slutsker, Laurence] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Ctr Global Hlth, Atlanta, GA 30333 USA. [Kachur, Stephen P.; MacArthur, John R.] US Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA 30341 USA. RP Slutsker, L (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Ctr Global Hlth, Mailstop F-22,1600 Clifton Rd, Atlanta, GA 30333 USA. EM lms5@cdc.gov NR 9 TC 4 Z9 4 U1 0 U2 0 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD APR PY 2010 VL 8 IS 4 BP 365 EP 366 DI 10.1586/ERI.10.23 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 592KT UT WOS:000277378500002 PM 20377330 ER PT J AU Tate, JE Patel, MM Steele, AD Gentsch, JR Payne, DC Cortese, MM Nakagomi, O Cunliffe, NA Jiang, BM Neuzil, KM de Oliveira, LH Glass, RI Parashar, UD AF Tate, Jacqueline E. Patel, Manish M. Steele, A. Duncan Gentsch, Jon R. Payne, Daniel C. Cortese, Margaret M. Nakagomi, Osamu Cunliffe, Nigel A. Jiang, Baoming Neuzil, Kathleen M. de Oliveira, Lucia H. Glass, Roger I. Parashar, Umesh D. TI Global impact of rotavirus vaccines SO EXPERT REVIEW OF VACCINES LA English DT Review DE diarrhea; rotavirus; rotavirus vaccination; vaccine effectiveness ID ORAL POLIOVIRUS VACCINE; PLACEBO-CONTROLLED TRIAL; 1ST 2 YEARS; UNITED-STATES; YOUNG-CHILDREN; DOUBLE-BLIND; DEVELOPING-COUNTRIES; PROTECTIVE IMMUNITY; CHILDHOOD DIARRHEA; RHESUS-HUMAN AB The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been observed. Besides protecting vaccinated children, disease rates also appear to be reduced in unvaccinated children, suggesting indirect benefits from vaccination (i.e., herd protection). Early clinical trial data from Africa and Asia are promising, and further efforts are needed to optimize the benefits of vaccination in developing countries where vaccines are likely to have their greatest impact. C1 [Tate, Jacqueline E.; Patel, Manish M.; Gentsch, Jon R.; Payne, Daniel C.; Cortese, Margaret M.; Jiang, Baoming; Parashar, Umesh D.] US CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Steele, A. Duncan; Neuzil, Kathleen M.] PATH, Rotavirus Vaccine Program, Seattle, WA USA. [Nakagomi, Osamu] Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Nagasaki 852, Japan. [Cunliffe, Nigel A.] Univ Liverpool, Dept Med Microbiol & Genitourinary, Liverpool L69 3BX, Merseyside, England. [de Oliveira, Lucia H.] Pan Amer Hlth Org, Immunizat Unit, Family & Community Hlth, Washington, DC 20037 USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Tate, JE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS A47, Atlanta, GA 30333 USA. EM jqt8@cdc.gov RI Inada, Mami/G-4783-2011; OI Cunliffe, Nigel/0000-0002-5449-4988 FU GSK Biologicals; SPMSD; GlaxoSmithKline; Banyu Pharmatheuticals FX Nigel A Cunliffe has received research grant support and lecture fees from GSK Biologicals and SPMSD. Osamu Nakagomi has received research grants from GlaxoSmithKline and Banyu Pharmatheuticals. Jacqueline E Tate, Manish M Patel, A Duncan Steele, Jon R Gentsch, Daniel C Payne, Margaret M Cortese, Baoming Jiang, Roger I Glass and Umesh D Parashar do not have any relevant disclosures. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 128 TC 55 Z9 58 U1 0 U2 11 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD APR PY 2010 VL 9 IS 4 BP 395 EP 407 DI 10.1586/ERV.10.17 PG 13 WC Immunology SC Immunology GA 590GV UT WOS:000277214200013 PM 20370550 ER PT J AU Hall, JE AF Hall, Jeffrey E. TI Foreword SO FAMILY & COMMUNITY HEALTH LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Atlanta, GA 30333 USA. RP Hall, JE (reprint author), Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Atlanta, GA 30333 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0160-6379 J9 FAM COMMUNITY HEALTH JI Fam. Community Health PD APR-JUN PY 2010 VL 33 IS 2 BP 80 EP 81 DI 10.1097/FCH.0b013e3181dbdf68 PG 2 WC Family Studies; Public, Environmental & Occupational Health SC Family Studies; Public, Environmental & Occupational Health GA 573IA UT WOS:000275902800002 PM 20216350 ER PT J AU Parker, VG Coles, C Logan, BN Davis, L AF Parker, Veronica G. Coles, Charlton Logan, Barbara N. Davis, Leroy TI The LIFE Project A Community-Based Weight Loss Intervention Program for Rural African American Women SO FAMILY & COMMUNITY HEALTH LA English DT Article DE African American; rural; weight loss intervention ID PHYSICAL-ACTIVITY; ADULTS; RATES AB Obesity continues to be a significant health problem for African American women. While a number of obesity interventions target urban African American women, few target rural ones. The LIFE Project is a 10-week intervention designed to reduce obesity in this rural population. Two different interventions (spiritually based and nonspiritually based) were pilot tested, each utilizing a pretest, posttest design. Results demonstrated that both interventions led to significant reductions in weight, but the spiritually based intervention led to additional improvements. The LIFE Project also demonstrated that churches are appropriate settings to deliver health interventions to these women. C1 [Parker, Veronica G.; Logan, Barbara N.] Clemson Univ, Sch Nursing, Clemson, SC 29634 USA. [Parker, Veronica G.; Logan, Barbara N.] Clemson Univ, Ctr Res Hlth Dispar, Clemson, SC 29634 USA. [Coles, Charlton] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Div Toxicol & Environm Med, Atlanta, GA USA. [Davis, Leroy] Voorhees Coll, Ctr Excellence Rural & Minor Hlth, Denmark, SC USA. RP Parker, VG (reprint author), Clemson Univ, Sch Nursing, Clemson, SC 29634 USA. EM veronic@clemson.edu RI Parker, Veronica/I-5160-2013 OI Parker, Veronica/0000-0002-5217-4569 FU NIMHD NIH HHS [P20 MD000539, P20 MD000539-04, P20 MD000539-019001, 1P20MD000539-01] NR 24 TC 20 Z9 20 U1 2 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0160-6379 J9 FAM COMMUNITY HEALTH JI Fam. Community Health PD APR-JUN PY 2010 VL 33 IS 2 BP 133 EP 143 DI 10.1097/FCH.0b013e3181d594d5 PG 11 WC Family Studies; Public, Environmental & Occupational Health SC Family Studies; Public, Environmental & Occupational Health GA 573IA UT WOS:000275902800008 PM 20216356 ER PT J AU Bailey, R Carriquiry, A Gahche, J Dodd, K Joseph, M Dwyer, J Yetley, E Sempos, C Picciano, MF AF Bailey, Regan Carriquiry, Alicia Gahche, Jaime Dodd, Kevin Joseph, Maria Dwyer, Johanna Yetley, Elizabeth Sempos, Chris Picciano, Mary Frances TI Adjusting Serum Biomarkers of Folate Status for Within-person Variation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bailey, Regan; Dwyer, Johanna; Yetley, Elizabeth; Sempos, Chris; Picciano, Mary Frances] NIH, Bethesda, MD 20892 USA. [Carriquiry, Alicia; Joseph, Maria] Iowa State Univ, Ames, IA USA. [Gahche, Jaime] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Dodd, Kevin] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505093 ER PT J AU Bailey, R Gahche, J Mills, J Dodd, K Dwyer, J Yetley, E Sempos, C Carriquiry, A Joseph, M Picciano, MF AF Bailey, Regan Gahche, Jaime Mills, James Dodd, Kevin Dwyer, Johanna Yetley, Elizabeth Sempos, Chris Carriquiry, Alicia Joseph, Maria Picciano, Mary Frances TI Unmetabolized Serum Folic Acid in Older Adults in the United States SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bailey, Regan; Dwyer, Johanna; Yetley, Elizabeth; Sempos, Chris; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Gahche, Jaime] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Mills, James] NICHHD, NIH, Bethesda, MD 20892 USA. [Dodd, Kevin] NCI, NIH, Bethesda, MD 20892 USA. [Carriquiry, Alicia; Joseph, Maria] Iowa State Univ, Ames, IA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504898 ER PT J AU Ceridon, ML Anderson, PJ Miller, AD Beck, KC OMalley, KA Johnson, JB Johnson, BD AF Ceridon, M. L. Anderson, P. J. Miller, A. D. Beck, K. C. OMalley, K. A. Johnson, J. B. Johnson, B. D. TI Physical Activity and the Incidence of Acute Mountain Sickness in United States Antarctic Program Participants Following Rapid Transport to the South Pole: Antarctic Study of Altitude Physiology (ASAP) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ceridon, M. L.; Miller, A. D.; Beck, K. C.; OMalley, K. A.; Johnson, J. B.; Johnson, B. D.] Mayo Clin, Rochester, MN USA. [Anderson, P. J.] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504682 ER PT J AU Cogswell, M Pfeiffer, C Tinker, S Berry, RJ AF Cogswell, Mary Pfeiffer, Christine Tinker, Sarah Berry, Robert J. TI Usual folic acid intake and folate status in US women aged 12-49 years, National Health and Nutrition Examination Survey (NHANES), 2001-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cogswell, Mary; Tinker, Sarah; Berry, Robert J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Pfeiffer, Christine] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502489 ER PT J AU Crider, KS Bean, C Berry, RJ Rasmussen, S Yang, T Hao, L Zhu, L Zhu, JH Maneval, D Quinlivan, E Bailey, L Brant, J AF Crider, Krista Stimson Bean, Christopher Berry, Robert J. Rasmussen, Sonja Yang, Thomas Hao, Ling Zhu, Li Zhu, Jainghui Maneval, David Quinlivan, Eoin Bailey, Lynn Brant, Jason TI Are there changes in DNA methylation at tumor suppressor, imprinting or oncogenes in response to chronic consumption and withdrawal of folic acid? SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Crider, Krista Stimson; Bean, Christopher; Berry, Robert J.; Rasmussen, Sonja] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Yang, Thomas; Maneval, David; Quinlivan, Eoin; Bailey, Lynn; Brant, Jason] Univ Florida, Gainesville, FL USA. [Hao, Ling; Zhu, Li; Zhu, Jainghui] Peking Univ, Hlth Sci Ctr, Natl Ctr Maternal & Infant Hlth, Beijing 100871, Peoples R China. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502392 ER PT J AU Drammeh, BS Mandava, U Zhang, MD Schleicher, RL Pfeiffer, CM AF Drammeh, Bakary S. Mandava, Usha Zhang, Mindy Schleicher, Rosemary L. Pfeiffer, Christine M. TI Capillary vs venous blood: delayed measurement of hemoglobin concentrations and hematocrit SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Drammeh, Bakary S.; Mandava, Usha; Zhang, Mindy; Schleicher, Rosemary L.; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Drammeh, Bakary S.; Mandava, Usha] Battelle Mem Inst, Columbus, OH 43201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501361 ER PT J AU Fazili, Z Bailey, SW Paladugula, N Ayling, JE Pfeiffer, CM AF Fazili, Zia Bailey, Steven W. Paladugula, Neelima Ayling, June E. Pfeiffer, Christine M. TI Interconversions of plasma folate species in response to dosing with oral folic acid and 5-methyltetrahydrofolate: an LC-MS/MS pilot study SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Fazili, Zia; Paladugula, Neelima; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Bailey, Steven W.; Ayling, June E.] Univ S Alabama, Dept Pharmacol, Mobile, AL 36688 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501354 ER PT J AU Gahche, JJ Bailey, R Mirel, L Dwyer, J Russell, R Sempos, C Picciano, MF AF Gahche, Jaime Jacqueline Bailey, Regan Mirel, Lisa Dwyer, Johanna Russell, Robert Sempos, Christopher Picciano, Mary Frances TI Iodine intake from dietary supplements among pregnant females in the US: National Health and Nutrition Examination Survey 1999-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gahche, Jaime Jacqueline; Mirel, Lisa] Natl Ctr Hlth Stat, CDC, Hyattsville, MD 20782 USA. [Bailey, Regan; Dwyer, Johanna; Russell, Robert; Sempos, Christopher; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504726 ER PT J AU Grant, F Suchdev, P Cole, CR Ramakrishnan, U Flores-Ayala, R Martorell, R AF Grant, Frederick Suchdev, Parmi Cole, Conrad R. Ramakrishnan, Usha Flores-Ayala, Rafael Martorell, Reynaldo TI Correcting for the influence of inflammation improves the accuracy for estimation of iron status among preschoolers in western Kenya SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Grant, Frederick; Cole, Conrad R.; Ramakrishnan, Usha] Emory Univ, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA. [Suchdev, Parmi; Cole, Conrad R.] Emory Univ, Sch Med, Atlanta, GA USA. [Ramakrishnan, Usha; Martorell, Reynaldo] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Suchdev, Parmi; Flores-Ayala, Rafael] CDC, Nutr Branch, Atlanta, GA 30333 USA. RI Ramakrishnan, Usha/L-8921-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500763 ER PT J AU Hamner, HC Cogswell, ME Johnson, MA AF Hamner, Heather Carter Cogswell, Mary E. Johnson, Mary Ann TI Acculturation factors and usual folate intakes among Mexican American women: National Health and Nutrition Examination Survey (NHANES), 2003-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hamner, Heather Carter; Cogswell, Mary E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Johnson, Mary Ann] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501364 ER PT J AU Hamner, HC Cogswell, ME Johnson, MA AF Hamner, Heather Carter Cogswell, Mary E. Johnson, Mary Ann TI Acculturation factors and the proportion of older Mexican Americans with inadequate folate intakes: National Health and Nutrition Examination Survey (NHANES), 2003-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hamner, Heather Carter; Cogswell, Mary E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Johnson, Mary Ann] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501360 ER PT J AU Lalande, S Ceridon, ML Anderson, PJ Miller, AD Beck, KC O'Malley, KA Johnson, JB Johnson, BD AF Lalande, S. Ceridon, M. L. Anderson, P. J. Miller, A. D. Beck, K. C. O'Malley, K. A. Johnson, J. B. Johnson, B. D. TI Variability in pulmonary function changes in United States Antarctic Program participants following rapid transport to the South Pole SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lalande, S.; Ceridon, M. L.; Miller, A. D.; Beck, K. C.; O'Malley, K. A.; Johnson, J. B.; Johnson, B. D.] Mayo Clin, Rochester, MN USA. [Anderson, P. J.] Ctr Dis Control & Prevent, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675505532 ER PT J AU Mandava, U Drammeh, BS Zhang, MD Schleicher, RL Pfeiffer, CM AF Mandava, Usha Drammeh, Bakary S. Zhang, Mindy Schleicher, Rosemary L. Pfeiffer, Christine M. TI Three models of HemoCue photometers: comparison of venous blood hemoglobin concentrations and influence of heat on cuvettes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mandava, Usha; Drammeh, Bakary S.; Zhang, Mindy; Schleicher, Rosemary L.; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Mandava, Usha; Drammeh, Bakary S.] Battelle Mem Inst, Columbus, OH 43201 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501357 ER PT J AU Pao, CI Rybak, ME Pfeiffer, CM AF Pao, Ching-I Rybak, Michael E. Pfeiffer, Christine M. TI Caffeine exposure biomonitoring: correlation and variability of urinary caffeine metabolites SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pao, Ching-I] Battelle Mem Inst, Atlanta, GA USA. [Pao, Ching-I; Rybak, Michael E.; Pfeiffer, Christine M.] US Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501367 ER PT J AU Park, S Sherry, B O'Toole, T AF Park, Sohyun Sherry, Bettylou O'Toole, Terrence TI Drinking water intake among adolescents: associations with sociodemographic and behavioral variables- Florida, 2007 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Park, Sohyun; Sherry, Bettylou] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [O'Toole, Terrence] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675506840 ER PT J AU Parker, ME Bentley, ME Adair, L Jamieson, D Ellingston, S Chasela, C Mkhomawanthu, C Tembo, M Martinson, F van der Horst, C AF Parker, Megan E. Bentley, Margaret E. Adair, Linda Jamieson, Denise Ellingston, Sascha Chasela, Charles Mkhomawanthu, Chimwemwe Tembo, Martin Martinson, Francis van der Horst, Charles TI The feasibility of replacement feeding as an HIV prevention method in Lilongwe, Malawi: Results of the BAN Study SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Parker, Megan E.; Bentley, Margaret E.; Adair, Linda; van der Horst, Charles] Univ N Carolina, Chapel Hill, NC USA. [Jamieson, Denise; Ellingston, Sascha] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chasela, Charles; Mkhomawanthu, Chimwemwe; Tembo, Martin; Martinson, Francis] UNC Projects Malawi, Lilongwe, Malawi. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500237 ER PT J AU Ruth, LJ Grant, F Mandava, U Quick, R Patel, M Mbkaya, C Jefferds, ME Woodruff, B Suchdev, P AF Ruth, Laird J. Grant, Frederick Mandava, Usha Quick, Robert Patel, Minal Mbkaya, Charles Jefferds, Maria Elena Woodruff, Bradley Suchdev, Parminder TI Impact of SprinklesTM on reducing childhood vitamin A deficiency in western Kenya SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ruth, Laird J.; Mandava, Usha; Quick, Robert; Patel, Minal; Jefferds, Maria Elena; Suchdev, Parminder] Ctr Dis Control & Prevent, Atlanta, GA USA. [Grant, Frederick; Woodruff, Bradley; Suchdev, Parminder] Emory Univ, Atlanta, GA 30322 USA. [Mbkaya, Charles] Kenya Govt Med Res Ctr, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675507325 ER PT J AU Rybak, ME Jain, RB Pfeiffer, CM AF Rybak, Michael E. Jain, Ram B. Pfeiffer, Christine M. TI Urinary phytoestrogen biomarkers in the US population: findings from the National Health and Nutrition Examination Survey (NHANES 1999-2004) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rybak, Michael E.; Jain, Ram B.; Pfeiffer, Christine M.] US Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500577 ER PT J AU Schleicher, RL Carroll, MD Lacher, DA AF Schleicher, Rosemary L. Carroll, Margaret D. Lacher, David A. TI Vitamin C deficiency in low-income persons in the United States: 2003-2006 National Health and Nutrition Examination Survey (NHANES) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Carroll, Margaret D.; Lacher, David A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501359 ER PT J AU Simonian, MH Nair, M Jacky, L Chang, GJ AF Simonian, Michael Haig Nair, Mahalakshmi Jacky, Lucien Chang, Gwong-Jen TI Production of recombinant dengue virus-like particles by COS-1 cells in a serum-free defined medium SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Simonian, Michael Haig; Nair, Mahalakshmi; Jacky, Lucien] Focus Diagnosit Inc, Res & Dev, Cypress, CA USA. [Chang, Gwong-Jen] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675502799 ER PT J AU Stein, AD Wang, M Martorell, R Neufeld, L Flores-Ayala, R Rivera, J Ramakrishnan, U AF Stein, Aryeh D. Wang, Meng Martorell, Reynaldo Neufeld, Lynnette Flores-Ayala, Rafael Rivera, Juan Ramakrishnan, Usha TI Postnatal growth following maternal gestational supplementation with docosahexanoic acid (DHA): randomized placebo-controlled trial in Mexico SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Stein, Aryeh D.; Wang, Meng; Martorell, Reynaldo; Ramakrishnan, Usha] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Neufeld, Lynnette; Rivera, Juan] INSP, Cuernavaca, Morelos, Mexico. [Flores-Ayala, Rafael] CDC, Atlanta, GA 30333 USA. RI Ramakrishnan, Usha/L-8921-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500538 ER PT J AU Thomas, RM Adair, L Chasela, C Bentley, M Siega-Riz, AM Knight, R Piwoz, E Ahmed, Y Mkhomawanthu, C Martinson, F Chitsulo, P Kayira, D Jamieson, D van der Horst, C AF Thomas, Roshan M. Adair, Linda Chasela, Charles Bentley, Margaret Siega-Riz, Anna Maria Knight, Rod Piwoz, Ellen Ahmed, Yusuf Mkhomawanthu, Chimwemwe Martinson, Francis Chitsulo, Pindile Kayira, Dumbani Jamieson, Denise van der Horst, Charles TI Maternal body composition in pregnancy among HIV-infected Malawians: Results of the BAN Study SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Thomas, Roshan M.; Adair, Linda; Bentley, Margaret; Siega-Riz, Anna Maria; Knight, Rod; Piwoz, Ellen; van der Horst, Charles] UNC, Chapel Hill, NC USA. [Chasela, Charles; Mkhomawanthu, Chimwemwe; Martinson, Francis; Chitsulo, Pindile; Kayira, Dumbani] UNC, Lilongwe, Malawi. [Ahmed, Yusuf; Jamieson, Denise] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504293 ER PT J AU Tinker, SC Cogswell, ME Devine, OJ Berry, RJ AF Tinker, Sarah C. Cogswell, Mary E. Devine, Owen J. Berry, Robert J. TI Usual Folic Acid Intake among US Women Aged 15-44 Years, NHANES, 2003-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tinker, Sarah C.; Cogswell, Mary E.; Devine, Owen J.; Berry, Robert J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675500854 ER PT J AU Yeung, L Cogswell, M Carriquiry, A Bailey, L Berry, R AF Yeung, Lorraine Cogswell, Mary Carriquiry, Alicia Bailey, Lynn Berry, Robert TI Folic acid source, usual intake, and serum folate concentrations in US children, the National Health and Nutrition Examination Survey (NHANES) 2003-2006 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yeung, Lorraine; Cogswell, Mary; Berry, Robert] Ctr Dis Control & Prevent, Atlanta, GA USA. [Carriquiry, Alicia] Iowa State Univ, Dept Stat, Ames, IA USA. [Bailey, Lynn] Univ Florida, Dept Food & Sci & Human Nutr, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675504179 ER PT J AU Petersen, JM Molins, CR AF Petersen, Jeannine M. Molins, Claudia R. TI Subpopulations of Francisella tularensis ssp tularensis and holarctica: identification and associated epidemiology SO FUTURE MICROBIOLOGY LA English DT Review DE epidemiology; Francisella tularensis; molecular typing; subpopulations; type A; type B ID MOLECULAR EPIDEMIOLOGY; UNITED-STATES; POPULATION-STRUCTURE; CITRULLINE UREIDASE; PNEUMONIC TULAREMIA; MARTHAS-VINEYARD; GUINEA-PIGS; VIRULENCE; STRAINS; PHYLOGEOGRAPHY AB Tularemia is primarily caused by two subspecies of Francisella tularensis worldwide, ssp. tularensis (type A) and ssp. holarctica (type B), which were originally delineated by phenotypic differences. Application of molecular typing methods to investigate population structure of F. tularensis has confirmed that catagorizing the two subspecies via phenotypic characteristics corresponds with genotypic differentiation. In addition, genotyping methods have demonstrated that both subspecies, type A and type B. can be further distinguished into subpopulations and, in some cases, biological relevance has been ascribed to these identified subpopulations. Genetic variation among both type A and type B subpopulations has been shown to correlate with differences in geographic distribution and has also been coupled to distinct ecological niches, animal hosts and replication foci. Among type A subpopulations, strain variation is linked to differing clinical manifestations in humans and virulence in mice. This article will highlight our current understanding of F. tularensis subpopulations, including methods for their detection, their observed epidemiologic differences, implications for public health and basic research programs, as well as future challenges yet to be solved. C1 [Petersen, Jeannine M.; Molins, Claudia R.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Bacterial Dis Branch, Ft Collins, CO 80521 USA. RP Petersen, JM (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Bacterial Dis Branch, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM jpetersen@cdc.gov NR 68 TC 25 Z9 25 U1 0 U2 5 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0913 J9 FUTURE MICROBIOL JI Future Microbiol. PD APR PY 2010 VL 5 IS 4 BP 649 EP 661 DI 10.2217/FMB.10.17 PG 13 WC Microbiology SC Microbiology GA 588DZ UT WOS:000277048900016 PM 20353304 ER PT J AU Botkin, JR Teutsch, SM Kaye, CI Hayes, M Haddow, JE Bradley, LA Szegda, K Dotson, WD AF Botkin, Jeffrey R. Teutsch, Steven M. Kaye, Celia I. Hayes, Maxine Haddow, James E. Bradley, Linda A. Szegda, Kathleen Dotson, W. David CA EGAPP Working Grp TI Outcomes of interest in evidence-based evaluations of genetic tests SO GENETICS IN MEDICINE LA English DT Article DE genetic test; outcomes; analytic validity; clinical validity; clinical utility; molecular diagnostic techniques; screening; penetrance; expressivity; genetic counseling ID NONPOLYPOSIS COLORECTAL-CANCER; EGAPP-WORKING-GROUP; SERVICES-TASK-FORCE; PSYCHOLOGICAL IMPACT; BREAST-CANCER; REDUCING MORBIDITY; SOCIETY GUIDELINES; DECISION-MAKING; OVARIAN-CANCER; LYNCH SYNDROME AB Genetic tests are increasingly available for use in traditional clinical practice settings and through direct-to-consumer marketing. The need for evidence-based information and guidance on their appropriate use has never been more apparent. The independent Working Group of the Evaluation of Genomic Applications in Practice and Prevention Initiative commissions evidence-based reviews and develops recommendations to inform decision making surrounding the implementation of genetic tests and other applications of genomic technologies into clinical practice. A critical component of this analysis involves the identification and appropriate weighting of relevant health outcomes from genetic testing. Impacts of testing on morbidity and mortality are central considerations although research to document such outcomes can be challenging to conduct. In considering the broader impacts of genetic tests on the individual, familial and societal levels, psychosocial outcomes often take on increasing importance, and their systematic evaluation is a challenge for traditional methods of evidence-based review. Incorporating these types of outcomes in evidence-based processes is possible, however, and necessary to extract balanced and complete (or as complete as available data will allow) information on potential benefits and on potential harms. The framework used by the Evaluation of Genomic Applications in Practice and Prevention Working Group in considering, categorizing, and weighting health-related outcomes as applied to genomic technologies is presented here. Genet Med 2010: 12(4): 228-235. C1 [Botkin, Jeffrey R.] Univ Utah, Dept Pediat & Med Eth, Salt Lake City, UT 84112 USA. [Teutsch, Steven M.] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [Kaye, Celia I.] Univ Colorado, Sch Med, Dept Pediat, Denver, CO USA. [Hayes, Maxine] Washington State Dept Hlth, Olympia, WA USA. [Haddow, James E.; Bradley, Linda A.] Brown Univ, Women & Infants Hosp, Alpert Med Sch, Providence, RI USA. [Bradley, Linda A.; Dotson, W. David] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. [Szegda, Kathleen] Baystate Childrens Hosp, Springfield, MA USA. RP Botkin, JR (reprint author), Univ Utah, Dept Pediat & Med Eth, Salt Lake City, UT 84112 USA. EM Jeffrey.botkin@hsc.utah.edu OI Dotson, William David/0000-0002-9606-6594 NR 61 TC 40 Z9 40 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-3600 J9 GENET MED JI Genet. Med. PD APR PY 2010 VL 12 IS 4 BP 228 EP 235 DI 10.1097/GIM.0b013e3181cdde04 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA 583VX UT WOS:000276709200007 PM 20118789 ER PT J AU Bellcross, C AF Bellcross, Cecelia TI Further development and evaluation of a breast/ovarian cancer genetics referral screening tool SO GENETICS IN MEDICINE LA English DT Letter C1 Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. RP Bellcross, C (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. NR 1 TC 12 Z9 12 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-3600 J9 GENET MED JI Genet. Med. PD APR PY 2010 VL 12 IS 4 BP 240 EP 240 DI 10.1097/GIM.0b013e3181d4bc3a PG 1 WC Genetics & Heredity SC Genetics & Heredity GA 583VX UT WOS:000276709200009 PM 20395744 ER PT J AU Mochalova, L Bright, R Xu, XY Korchagina, E Chinarev, A Bovin, N Klimov, A AF Mochalova, Larisa Bright, Rick Xu, Xiyan Korchagina, Elena Chinarev, Alexander Bovin, Nicolai Klimov, Alexander TI Shift in oligosaccharide specificities of hemagglutinin and neuraminidase of influenza B viruses resistant to neuraminidase inhibitors SO GLYCOCONJUGATE JOURNAL LA English DT Article DE Influenza B virus; Neuraminidase; Neuraminidase inhibitor; Drug resistance; Hemagglutinin; Receptor-binding specificity; Neuraminidase substrate specificity ID RECEPTOR-BINDING PROPERTIES; A VIRUS; MDCK CELLS; POSTREASSORTMENT CHANGES; EMBRYONATED EGGS; SIALIC-ACID; GLYCOSYLATION; REPLICATION; ADJUSTMENT; ZANAMIVIR AB Influenza virus neuraminidase inhibitors (NAIs), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. Resistance to NAIs appears due to mutations in the active site of the neuraminidase (NA) molecule that decrease the NA enzymatic activity and sometimes in the hemagglutinin (HA) that decrease its affinity for cell receptors and, therefore, reduce the requirement for NA activity in releasing mature virions from infected cells. Using a set of sialo-oligosaccharides, we evaluated changes in the receptor-binding specificity of the HA and substrate specificity of the NA of influenza B viruses that had acquired resistance to NAIs. The oligosaccharide specificity of two pairs of field influenza B viruses, namely: i) B/Memphis/20/96 and its NAI-resistant variant, B/Memphis/20-152K/96, containing mutation R152K in the NA and 5 amino acid substitutions in the HA1, and ii) B/Hong Kong/45/2005 and its NAI-resistant variant B/Hong Kong/36/2005, containing a single R371K mutation in the NA, was evaluated. Wild type viruses bound strictly to a "human type" receptor, alpha 2-6-sialo-oligosaccharide 6`SLN, but desialylated it is approximately 8 times less efficiently than the alpha 2-3 sialosaccharides. Both drug-resistant viruses demonstrated the ability to bind to "avian type" receptors, alpha 2-3 sialo-oligosaccharides (such as 3`SLN), whereas their affinity for 6`SLN was noticeably reduced in comparison with corresponding wild type viruses. Thus, the development of the NAI resistance in the studied influenza B viruses was accompanied by a readjustment of HA-NA oligosaccharide specificities. C1 [Bright, Rick; Xu, Xiyan; Klimov, Alexander] CDC, Virus Surveillance & Diag Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA. [Mochalova, Larisa; Korchagina, Elena; Chinarev, Alexander; Bovin, Nicolai] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia. RP Klimov, A (reprint author), CDC, Virus Surveillance & Diag Branch, Influenza Div, NCIRD, Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM larisamochalova@gmail.com; bovin@carb.ibch.ru; axk0@cdc.gov FU Russian Foundation for Basic Research [07-04-00663]; ISTC [2464]; RAS Presidium Program "Molecular and Cell Biology" FX We are profoundly grateful to Dr. Larisa V. Gubareva and Dr. Nikolay V. Kaverin for their critical comments. This work was supported by grant of Russian Foundation for Basic Research 07-04-00663, ISTC #2464, and RAS Presidium Program "Molecular and Cell Biology". NR 38 TC 4 Z9 4 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0282-0080 J9 GLYCOCONJUGATE J JI Glycoconjugate J. PD APR PY 2010 VL 27 IS 3 BP 321 EP 327 DI 10.1007/s10719-010-9280-7 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 576SI UT WOS:000276168200003 PM 20195900 ER PT J AU Thorpe, KE Ogden, LL Galactionova, K AF Thorpe, Kenneth E. Ogden, Lydia L. Galactionova, Katya TI Chronic Conditions Account For Rise In Medicare Spending From 1987 To 2006 SO HEALTH AFFAIRS LA English DT Article ID UNITED-STATES; US ADULTS; HEALTH; PREVALENCE AB Medicare beneficiaries' medical needs, and where beneficiaries undergo treatment, have changed dramatically over the past two decades. Twenty years ago, most spending growth was linked to intensive inpatient (hospital) services, chiefly for heart disease. Recently, much of the growth has been attributable to chronic conditions such as diabetes, arthritis, hypertension, and kidney disease. These conditions are chiefly treated not in hospitals but in outpatient settings and by patients at home with prescription drugs. Health reform must address changed health needs through evidence-based community prevention, care coordination, and support for patient self-management. C1 [Thorpe, Kenneth E.; Galactionova, Katya] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. [Ogden, Lydia L.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Thorpe, KE (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. EM kthorpe@sph.emory.edu FU Peter G. Peterson Foundation FX This research is part of a larger project funded by the Peter G. Peterson Foundation that analyzes factors responsible for the rise in federal entitlement spending; links new approaches in financing, payment, and care delivery for achieving better value; and outlines options for policy makers. The authors gratefully acknowledge the foundation's support. [Published online 18 February 2010.] NR 20 TC 81 Z9 81 U1 1 U2 11 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD APR PY 2010 VL 29 IS 4 BP 718 EP 724 DI 10.1377/hlthaff.2009.0474 PG 7 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA 579HS UT WOS:000276360200022 PM 20167626 ER PT J AU Moyer, ES Miller, WE Commodore, MA Coffey, CC Hayes, JL Fotta, SA Sims, G AF Moyer, Ernest S. Miller, William E. Commodore, Michael A. Coffey, Chris C. Hayes, Jeffrey L. Fotta, Steven A. Sims, George TI Aerosol and Biological Sampling of a Ventilation Fan-bank Modified with Ultraviolet Germicidal Irradiation and Improved Filter Holders SO INDOOR AND BUILT ENVIRONMENT LA English DT Article DE Filtration; Indoor environment; Aerosol particles; Control technology; Particle counter ID AIR; TUBERCULOSIS; SYSTEMS; HEALTH; WARD AB Two independent modifications were made to one of two identical side-by-side filter banks for a large air-handler: ( 1) new filter holders, intended to provide a better seal and ( 2) ultraviolet germicidal irradiation (UVGI) lamps, intended to control microbiological growth. Total system efficiency testing with optical particle counters was performed to determine the effectiveness of the new filter holders. The efficacy of the UVGI lamps was determined through biological surface and air sampling. Results indicated that the side with the new filter holders was about 3.4% more efficient per year during the 22-month sampling period, whereas the coil chamber with the UVGI lamps had less biological contamination than the corresponding control chamber for over 75% of the sampling days. C1 [Miller, William E.] Ctr Dis Control & Prevent, NIOSH, Dept Hlth & Human Serv, Div Resp Dis Studies, Morgantown, WV 26505 USA. [Hayes, Jeffrey L.; Fotta, Steven A.; Sims, George] NIOSH, Adm Serv Branch, Off Adm & Management Serv, Morgantown, WV 26505 USA. RP Miller, WE (reprint author), Ctr Dis Control & Prevent, NIOSH, Dept Hlth & Human Serv, Div Resp Dis Studies, 1095 Willowdale Rd,Mailstop 2800, Morgantown, WV 26505 USA. EM wem0@cdc.gov RI Coffey, Christopher/I-2471-2012 NR 20 TC 1 Z9 1 U1 1 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1420-326X J9 INDOOR BUILT ENVIRON JI Indoor Built Environ. PD APR PY 2010 VL 19 IS 2 BP 230 EP 238 DI 10.1177/1420326X09346221 PG 9 WC Construction & Building Technology; Engineering, Environmental; Public, Environmental & Occupational Health SC Construction & Building Technology; Engineering; Public, Environmental & Occupational Health GA 587YV UT WOS:000277033700004 ER PT J AU Egorov, AI Trimble, LMM Ascolillo, L Ward, HD Levy, DA Morris, RD Naumova, EN Griffiths, JK AF Egorov, A. I. Trimble, L. M. Montuori Ascolillo, L. Ward, H. D. Levy, D. A. Morris, R. D. Naumova, E. N. Griffiths, J. K. TI Recent Diarrhea is Associated with Elevated Salivary IgG Responses to Cryptosporidium in Residents of an Eastern Massachusetts Community SO INFECTION LA English DT Article ID ORAL FLUID COLLECTION; COAST-GUARD CUTTER; ANTIBODY-RESPONSES; IMMUNOGLOBULIN-G; UNITED-STATES; WATERBORNE DISEASE; PARVUM; SURVEILLANCE; CHILDREN; ANTIGEN AB Background: Serological data suggest that Cryptosporidium infections are common but underreported. The invasiveness of blood sampling limits the application of serology in epidemiological surveillance. We pilot-tested a non-invasive salivary anti-Ctyptosporidium antibody assay in a community survey involving children and adults. Materials and Methods: Families with children were recruited in a Massachusetts community in July; symptoms data were collected at 3 monthly follow-up mail surveys. One saliva sample per person (n = 349) was collected via mail, with the last survey in October. Samples were analyzed for IgG and IgA responses to a recombinant C. hominis gp15 sporozoite protein using a time-resolved fluorometric immunoassay. Log-transformed assay results were regressed on age using penalized B-splines to account for the strong age-dependence of antibody reactions. Positive responses were defined as fluorescence values above the upper 99% prediction limit. Results: Forty-seven (13.5%) individuals had diarrhea without concurrent respiratory symptoms during the 3-month-long follow-up; eight of them had these symptoms during the month prior to saliva sampling. Two individuals had positive IgG responses: an adult who had diarrhea during the prior month and a child who had episodes of diarrhea during each survey month (Fisher's exact test for an association between diarrhea and IgG response: p = 0.0005 for symptoms during the prior month and p = 0.02 for symptoms during the entire follow-up period). The child also had a positive IgA response, along with two asymptomatic individuals (an association between diarrhea and IgA was not significant). Conclusion: These results suggest that the salivary IgG specific to Ctyptosporidium antigens warrants further evaluation as a potential indicator of recent infections. C1 [Egorov, A. I.] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Egorov, A. I.; Trimble, L. M. Montuori; Ascolillo, L.; Ward, H. D.; Morris, R. D.; Naumova, E. N.; Griffiths, J. K.] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA. [Ward, H. D.; Griffiths, J. K.] Tufts Med Ctr, Dept Med, Div Geog Med & Infect Dis, Boston, MA USA. [Levy, D. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Griffiths, J. K.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA. [Griffiths, J. K.] Tufts Univ, Sch Engn, Dept Civil & Environm Engn, Medford, MA 02155 USA. [Griffiths, J. K.] Tufts Univ, Cummings Sch Vet Med, Grafton, MA USA. RP Egorov, AI (reprint author), US EPA, Natl Ctr Environm Assessment, 26 W Martin Luther King Dr,Mail Stop A110, Cincinnati, OH 45268 USA. EM egorov.andrey@epa.gov RI Naumova, Elena/C-5954-2011; OI Naumova, Elena/0000-0002-9562-4734 FU Centers for Disease Control and Prevention (CDC) [U 1161186, U 116566]; National Institutes of Health [R01 AI43415, R01 AI05786]; GRASP Digestive Diseases Center [P30 DK34928-18] FX This study was funded by the Centers for Disease Control and Prevention (CDC; grants U 1161186 and U 116566 to RDM and JKG), the National Institutes of Health (grants R01 AI43415 to JKG and R01 AI05786 to HDW), and the GRASP Digestive Diseases Center grant at Tufts-New England Medical Center (P30 DK34928-18). Preparation of this manuscript was funded in part by the US Environmental Protection Agency. The authors thank Anne Kane and the GRASP Intestinal Microbiology Core Laboratory for the production of recombinant antigens, the Director of the Newton Health Department, David Naparstek, for supporting this study, the numerous employees of Health and School departments for helping to organize the recruitment of study participants, and David Farrar (US EPA) for his helpful comments on the statistical data analysis. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency or the Centers for Disease Control and Prevention. The mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 38 TC 5 Z9 5 U1 0 U2 0 PU URBAN & VOGEL PI MUNICH PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY SN 0300-8126 J9 INFECTION JI Infection PD APR PY 2010 VL 38 IS 2 BP 117 EP 123 DI 10.1007/s15010-009-9323-4 PG 7 WC Infectious Diseases SC Infectious Diseases GA 584VI UT WOS:000276781100007 PM 20349105 ER PT J AU Gould, CV Umscheid, CA Agarwal, RK Kuntz, G Pegues, DA AF Gould, Carolyn V. Umscheid, Craig A. Agarwal, Rajender K. Kuntz, Gretchen Pegues, David A. CA HICPAC TI Guideline for Prevention of Catheter-Associated Urinary Tract Infections 2009 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material C1 [Gould, Carolyn V.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Gould, Carolyn V.; Agarwal, Rajender K.; Kuntz, Gretchen] Univ Penn Hlth Syst, Ctr Evidence Based Practice, Philadelphia, PA USA. [Pegues, David A.] Univ Calif Los Angeles, David Geffen Sch Med, Div Infect Dis, Los Angeles, CA 90095 USA. RP Gould, CV (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. NR 0 TC 216 Z9 230 U1 2 U2 23 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD APR PY 2010 VL 31 IS 4 BP 319 EP 326 DI 10.1086/651091 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 562DW UT WOS:000275030600001 PM 20156062 ER PT J AU Zhu, JH Hu, DJ Hao, L Zhang, BL Cogswell, ME Bailey, LB Li, Z Berry, RJ AF Zhu, Jiang Hui Hu, Dale J. Hao, Ling Zhang, Bao Lan Cogswell, Mary E. Bailey, Lynn B. Li, Zhu Berry, R. J. TI Iron, Folate, and B-12 Deficiencies and their Associations with Anemia among Women of Childbearing Age in a Rural Area in Northern China SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH LA English DT Article DE Folate; vitamin B-12; iron; anemia; China ID NEURAL-TUBE DEFECTS; VITAMIN-B-12 DEFICIENCY; FOLIC-ACID; SPONTANEOUS-ABORTION; PRETERM BIRTH; PLASMA FOLATE; B-VITAMIN; DIETARY; ADULTS; HOMOCYSTEINE AB Objective: To assess the prevalence of folate, vitamin B-12, and iron deficiencies and their associations with anemia among women of childbearing age in northern China, an area with a reported high incidence of neural tube defects. Methods: Plasma folate, vitamin B-12, ferritin, and hemoglobin levels were measured among 1,671 non-pregnant women of childbearing age from Xianghe County, Hebei Province, China in June 2004. Results: Geometric means [95 % confidence interval (CI)] of plasma concentrations were 9.3 (4.0, 21.6) nmol/L for folate, 213.1 (82.4, 550.9) pmol/L for vitamin B-12, 17.4 (1.1, 278.6) mu g/L for ferritin, and 129.9 (104.6, 161.4) g/L for hemoglobin (Hb). Approximately 24 % of women had biochemical evidence of folate deficiency (< 6.8 nmol/L), 21.4% were deficient (< 148 pmol/L) in vitamin B-12, 30.2 % had iron depletion (< 15 mu g/L), and anemia (Hb < 120 g/L) was detected among 15.4% of women. Of the three nutrients, only iron depletion (ferritin < 15 mu g/L) was independently associated with anemia (adjusted odds ratio = 6.4, 95 % CI 4.8, 8.6). C1 [Zhu, Jiang Hui; Hao, Ling; Li, Zhu] Peking Univ, Natl Reference Lab Reprod & Child Hlth, Minist Hlth, Hlth Sci Ctr, Beijing 100083, Peoples R China. [Zhu, Jiang Hui; Hao, Ling; Li, Zhu] Peking Univ, Natl Ctr Maternal & Child Hlth, Hlth Sci Ctr, Beijing 100083, Peoples R China. [Hu, Dale J.; Berry, R. J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Zhang, Bao Lan] Maternal & Child Hlth Inst, Xianghe Cty, Hebei Province, Peoples R China. [Bailey, Lynn B.] Univ Florida, Food Sci & Human Nutr Dept, Gainesville, FL USA. RP Hao, L (reprint author), Peking Univ, Natl Reference Lab Reprod & Child Hlth, Minist Hlth, Hlth Sci Ctr, Room 10-1,Res Ctr Bldg 38,Coll Rd, Beijing 100083, Peoples R China. EM haoling1380@gmail.com OI Berry, Robert/0000-0002-7162-5046 FU Centers for Disease Control and Prevention FX The study is supported by a cooperative agreement with the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. NR 40 TC 4 Z9 4 U1 1 U2 2 PU VERLAG HANS HUBER PI BERN 9 PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND SN 0300-9831 J9 INT J VITAM NUTR RES JI Int. J. Vitam. Nutr. Res. PD APR PY 2010 VL 80 IS 2 BP 144 EP 154 DI 10.1024/0300-9831.000014 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 656SW UT WOS:000282357900006 PM 20803428 ER PT J AU Mok-Lin, E Ehrlich, S Williams, PL Petrozza, J Wright, DL Calafat, AM Ye, X Hauser, R AF Mok-Lin, E. Ehrlich, S. Williams, P. L. Petrozza, J. Wright, D. L. Calafat, A. M. Ye, X. Hauser, R. TI Urinary bisphenol A concentrations and ovarian response among women undergoing IVF SO INTERNATIONAL JOURNAL OF ANDROLOGY LA English DT Article; Proceedings Paper CT 5th Copenhagen Workshop on Endocrine Disruptgers - Ubiquitous Endocrine Disrupters and Possible Human Health Effects CY MAY 20-22, 2009 CL Copenhagen, DENMARK DE bisphenol A; in vitro fertilization; human oestradiol; oocyte ID FOLLICLE-STIMULATING-HORMONE; GRANULOSA-CELLS; INVITRO FERTILIZATION; ESTRADIOL RESPONSE; GROWTH-FACTORS; EXPOSURE; FOLLICULOGENESIS; DIMETHACRYLATE; APOPTOSIS; ANIMALS AB P>Bisphenol A (BPA) is a synthetic chemical used in the manufacture of materials present in many common consumer products. In experimental animals, BPA caused oocyte aneuploidy and reduced production of oestradiol. In a prospective cohort study, we investigated the association between urinary BPA concentrations and ovarian response among women undergoing in vitro fertilization (IVF) at the Massachusetts General Hospital (MGH) Fertility Center. The geometric mean of two specific-gravity (SG) adjusted urinary BPA concentrations collected during each IVF cycle was used as the cycle-specific BPA exposure level. BPA concentrations were measured using online solid phase extraction coupled to isotope dilution-high-performance liquid chromatography-tandem mass spectrometry. Peak serum oestradiol was measured using the Elecsys Estradiol II immunoassay kit. Multivariable mixed effect models and Poisson regression models adjusting for correlation between multiple IVF cycles in the same woman were used to evaluate the association between urinary BPA concentrations and ovarian response, adjusting for age, BMI and day 3 follicle stimulating hormone (FSH) levels, a clinical measure of ovarian reserve. Urinary BPA concentrations were measured in 84 women (mean age 35.6 years) undergoing 112 IVF cycles; 23 women (27%) contributed more than one IVF cycle. BPA concentrations ranged from < 0.4 to 25.5 mu g/L (geometric mean 2.52 +/- SD 3.2); 15% of urine samples had concentrations < 0.4 mu g/L. Peak serum oestradiol levels correlated with the total number of oocytes retrieved per cycle (r = 0.65, p < 0.001). For each log unit increase in SG-BPA, there was an average decrease of 12% (95% CI: 4, 23%; p = 0.007) in the number of oocytes retrieved and an average decrease of 213 pg/ml (95% CI: -407, -20; p = 0.03) in peak oestradiol. BPA was detected in the urine of the majority of women undergoing IVF, and was inversely associated with number of oocytes retrieved and peak oestradiol levels. C1 [Mok-Lin, E.; Petrozza, J.; Wright, D. L.; Hauser, R.] Massachusetts Gen Hosp, Fertil Ctr, Boston, MA 02114 USA. [Ehrlich, S.; Hauser, R.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth Environm & Occupat Med & Epide, Boston, MA 02115 USA. [Williams, P. L.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Calafat, A. M.; Ye, X.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Hauser, R (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. EM rhauser@hsph.harvard.edu RI Ehrlich , Shelley/L-6991-2015 FU NIEHS NIH HHS [R01 ES009718, R01 ES009718-13]; NIOSH CDC HHS [R01 OH008578, OH008578] NR 41 TC 79 Z9 81 U1 1 U2 12 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0105-6263 J9 INT J ANDROL JI Int. J. Androl. PD APR PY 2010 VL 33 IS 2 BP 385 EP 393 DI 10.1111/j.1365-2605.2009.01014.x PG 9 WC Andrology SC Endocrinology & Metabolism GA 569XO UT WOS:000275636400027 PM 20002217 ER PT J AU Feikin, DR Audi, A Olack, B Bigogo, GM Polyak, C Burke, H Williamson, J Breiman, RF AF Feikin, Daniel R. Audi, Allan Olack, Beatrice Bigogo, Godfrey M. Polyak, Christina Burke, Heather Williamson, John Breiman, Robert F. TI Evaluation of the optimal recall period for disease symptoms in home-based morbidity surveillance in rural and urban Kenya SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Article DE Africa; diarrhoea; fever; memory recall; population surveillance; respiratory infections ID HEALTH INTERVIEW SURVEYS; CHILDHOOD DIARRHEA; WESTERN KENYA; RISK-FACTORS; CHILDREN; PREVALENCE; EXPERIENCE; BANGLADESH; EPISODES; BURDEN AB Background In African settings with poor access to health care, surveillance and surveys of disease burden are often done through home visits. The optimal recall period to capture data on symptoms and health utilization is unknown. Methods We collected illness data among 53 000 people during fortnightly home visits in rural and urban Kenya. Dates of cough, fever and diarrhoea in the past 2 weeks and health-seeking behaviour were recorded. Incidence rates were modelled using Poisson regression for data collected from 1 July 2006 to 30 June 2007. Results Incidence rates were higher in days 0-6 before the home visit than in days 7-13 before the home visit for all three symptoms, for the rural and urban sites, for children and adults, for self- and proxy-reported symptoms and for severe and non-severe illness in children. Recall decay was steeper in the rural than the urban sites, and for proxy- than self-reported symptoms. The daily prevalence of symptoms fell < 80% of the maximum prevalence when asking about symptoms > 3 days before the home visit for children and > 4 days for persons >= 5 years of age. Recall of previously documented clinic visits, and prescriptions of antimalarials and antibiotics also declined by similar to 7, 15 and 23% per week, respectively, in children aged < 5 years, and 6, 20 and 16%, respectively, in older persons (P < 0.0001 for each decline). Conclusions A 2-week recall period underestimates true disease rates and health-care utilization. Shorter recall periods of 3 days in children and 4 days in adults would likely yield more accurate data. C1 [Feikin, Daniel R.; Audi, Allan; Olack, Beatrice; Bigogo, Godfrey M.; Polyak, Christina; Burke, Heather; Breiman, Robert F.] Ctr Dis Control & Prevent, Nairobi, Kenya. [Feikin, Daniel R.; Audi, Allan; Olack, Beatrice; Bigogo, Godfrey M.; Polyak, Christina; Burke, Heather; Breiman, Robert F.] Ctr Dis Control & Prevent, Kisumu, Kenya. [Feikin, Daniel R.; Audi, Allan; Olack, Beatrice; Bigogo, Godfrey M.; Burke, Heather; Breiman, Robert F.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Williamson, John] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. RP Feikin, DR (reprint author), KEMRI CDC, POB 1578, Kisumu, Kenya. EM dfeikin@ke.cdc.gov NR 27 TC 64 Z9 64 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD APR PY 2010 VL 39 IS 2 BP 450 EP 458 DI 10.1093/ije/dyp374 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 578OT UT WOS:000276303800024 PM 20089695 ER PT J AU Tepper, NK Zapata, LB Jamieson, DJ Curtis, KM AF Tepper, Naomi K. Zapata, Lauren B. Jamieson, Denise J. Curtis, Kathryn M. TI Use of intrauterine devices in women with uterine anatomic abnormalities SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS LA English DT Article DE Intrauterine device; Mullerian anomaly; Uterine abnormality; Uterine synechiae ID BICORNUATE UTERUS; PREGNANCY; HORNS; IUD; SYNECHIAE; ANOMALIES AB Objective: To examine the evidence regarding the safety and effectiveness of intrauterine devices (IUDs) in women with uterine abnormalities. Methods: We searched PubMed for all peer-reviewed articles in any language that had been published on the topic from database inception to September 2009. Primary research articles were included if they addressed the safety or effectiveness of any type of IUD among women with Mullerian anomalies or uterine synechiae. Results: In total, 19 case reports or case series met the inclusion criteria. Reported complications included expulsion, pregnancy, bleeding, perforation, and pain. In several case reports, no complications were reported. Conclusion: Evidence concerning the safety and effectiveness of IUD use among women with uterine abnormalities is very limited. Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics. C1 [Tepper, Naomi K.; Zapata, Lauren B.; Jamieson, Denise J.; Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. RP Tepper, NK (reprint author), 4770 Buford Highway,MS K-34, Atlanta, GA 30341 USA. EM ntepper@cdc.gov NR 25 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0020-7292 J9 INT J GYNECOL OBSTET JI Int. J. Gynecol. Obstet. PD APR PY 2010 VL 109 IS 1 BP 52 EP 54 DI 10.1016/j.ijgo.2009.10.022 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 581RG UT WOS:000276541400015 PM 20034627 ER PT J AU Li, JH Munsiff, SS Tarantino, T Dorsinville, M AF Li, Jiehui Munsiff, Sonal S. Tarantino, Tania Dorsinville, Marie TI Adherence to treatment of latent tuberculosis infection in a clinical population in New York City SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Latent TB infection; Treatment; Tuberculosis prevention; Adherence ID RIFAMPIN PREVENTIVE THERAPY; TREATMENT COMPLETION; CONTROLLED-TRIAL; UNITED-STATES; DRUG-USERS; HOMELESS; OUTCOMES; ADULTS AB Background: Low adherence to treatment of latent tuberculosis infection (TLTBI) diminishes TB prevention efforts. This study examined the treatment completion rate among those who started TLTBI and factors associated with adherence to TLTBI. Methods: Patients who started TLTBI in New York City (NYC) Health Department chest clinics during January 2002 - August 2004 were studied. TLTBI completion rate were described and compared according to patient demographic and clinical characteristics by regimen using univariate analysis and log-binomial regression. Results: A total of 15 035 patients started and 6788 (45.2%) completed TLTBI. Treatment completers were more likely than non-completers to be >= 35 years old (52.5%, adjusted relative risk (aRR) = 1.2, 95% confidence interval (CI) = 1.1, 1.2), contacts to pulmonary TB patients (57.4%, aRR = 1.5, 95% CI = 1.4, 1.7), treated by directly observed preventive therapy (DOPT) (71.4%, aRR = 1.3, 95% CI = 1.2, 1.3), and to have received the rifamycin-based regimen (60.0%, aRR = 1.2, 95% CI = 1.1, 1.3). The completion rate with an isoniazid regimen did not differ between HIV-infected and HIV-uninfected persons. Among those who failed to complete, 3748 (47.8%) failed to return for isoniazid and 59 (14.7%) for rifamycin after the. first month of medication dispensing. Conclusions: Shorter regimen and DOPT increased completion rates for LTBI. Though efforts to improve TLTBI completion need to address all groups, greater focus is needed for persons who are contacts and HIV-infected, as they have higher risk of developing TB. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. C1 [Li, Jiehui; Munsiff, Sonal S.; Tarantino, Tania; Dorsinville, Marie] New York City Dept Hlth & Mental Hyg, New York, NY 10279 USA. [Munsiff, Sonal S.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Li, JH (reprint author), New York City Dept Hlth & Mental Hyg, 233 Broadway,26th Floor, New York, NY 10279 USA. EM jli3@health.nyc.gov FU NYC Department of Health and Mental Hygiene Bureau of TB Control funds FX The authors gratefully acknowledge Dr Cynthia R. Driver for her important contribution to the study and her valuable review of this manuscript. This work was supported by existing NYC Department of Health and Mental Hygiene Bureau of TB Control funds.; This study was approved by the NYC Department of Health and Mental Hygiene, Institutional Review Board, and was determined by the Associate Director for Science of the National Center for HIV, STD, and TB Prevention at the CDC not to be human subjects research requiring IRB review. NR 30 TC 35 Z9 37 U1 5 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD APR PY 2010 VL 14 IS 4 BP E292 EP E297 DI 10.1016/j.ijid.2009.05.007 PG 6 WC Infectious Diseases SC Infectious Diseases GA 571ZC UT WOS:000275794200003 PM 19656705 ER PT J AU Awan, S Nasrullah, M Cummings, KJ AF Awan, Saeed Nasrullah, Muallam Cummings, Kristin J. TI Health Hazards, Injury Problems, and Workplace Conditions of Carpet-Weaving Children in Three Districts of Punjab, Pakistan SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH LA English DT Article DE carpet weaving; child labor; carpet loom; wool; musculoskeletal; workplace; injuries; Punjab, Pakistan ID TUNNEL-SYNDROME; AGE AB Carpet weaving among children is common in rural Pakistan, but little information is available on the health effects of this work. A total of 628 carpet-weaving children and 292 non-working children from 10 rural villages were evaluated with questionnaires and physical exams. Fifty-five home-based and 30 shed-based worksites in these villages were assessed. Girls comprised the majority of working (73%) and non-working (69%) children; the mean age for both boys and girls was 10 years. The mean number of hours worked daily was 7.2 for males and 6.8 for females. Dust exposure in homes was generally higher than in sheds. Working children had significantly greater odds of joint pain (OR = 2.8), dry cough (OR = 2.5), cuts/bruises (OR = 22.1), Phalen's sign (OR = 17.2), and neck/shoulder abnormalities (OR = 14.2). Symptoms and signs of acute and repetitive injury and respiratory symptoms were more common among carpet-weaving children than their non-working peers. C1 [Awan, Saeed] Ctr Improvement Working Condit & Environm, Lahore, Pakistan. [Nasrullah, Muallam] W Virginia Univ, Injury Control Res Ctr, Morgantown, WV 26506 USA. [Nasrullah, Muallam] W Virginia Univ, Hlth Sci Ctr, Sch Med, Dept Community Med, Morgantown, WV 26506 USA. [Cummings, Kristin J.] Louis A Johnson VA Med Ctr, Clarksburg, WV USA. RP Nasrullah, M (reprint author), NIOSH, Ctr Dis Control & Prevent, 1095 Willowdale Rd,Mailstop H-2800, Morgantown, WV 26505 USA. EM snasrullah@cdc.gov FU International Program on Elimination of Child Labor (IPEC) of the International Labour Organization (ILO) FX The authors wish to thank the management of the International Program on Elimination of Child Labor (IPEC) of the International Labour Organization's (ILO) Carpet Project who supported this study. The following team members helped a great deal in collecting and analysis of the data: Arshad Mehmood (occupational hygienist); Muhammad Hanif (physician); Javaid Iqbal (technician); Muhammad Naeem (statistician). NR 16 TC 5 Z9 5 U1 1 U2 1 PU HAMILTON HARDY PUBL INC PI ATTLEBORO PA 8 N MAIN ST, STE 404A, ATTLEBORO, MA 02703 USA SN 1077-3525 J9 INT J OCCUP ENV HEAL JI Int. J. Occup. Environ. Health PD APR-JUN PY 2010 VL 16 IS 2 SI SI BP 115 EP 121 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 591ZH UT WOS:000277343600003 PM 20465056 ER PT J AU Hogben, M Chesson, H Aral, SO AF Hogben, M. Chesson, H. Aral, S. O. TI Sexuality education policies and sexually transmitted disease rates in the United States of America SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE gonorrhoea; chlamydia; North America ID SEX-EDUCATION; INTERVENTION; PREVENTION; INITIATION; PREGNANCY AB The aim of the study was to test for relationships between state-level sex educational policies and sexually transmitted disease (STD) rates. We analysed US case reports of gonorrhoea and chlamydial infection for 2001-2005 against state policies for abstinence coverage in sexuality education, using the proportion of the population per state who identified as black (aged 15-24 years) as a covariate. We also tested for effects on 15-19 year olds versus 35-39 year olds and tuberculosis rates (the latter to ensure findings applied only to STD). States with no mandates for abstinence had the lowest mean rates of infection among the overall population and among adolescents. States with mandates emphasizing abstinence had the highest rates; states with mandates to cover (but not emphasize) abstinence fell in between. Rates in some states covering abstinence changed faster than in others, as reflected in sharper declines (gonorrhoea) or slower increases (chlamydial infection). These effects were not shown for tuberculosis or 35-39 year olds. Having no abstinence education policy has no apparent effect on STD rates for adolescents. For states with elevated rates, policies mandating coverage may be useful, although policies emphasizing abstinence show no benefit. C1 [Hogben, M.; Chesson, H.; Aral, S. O.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Hogben, M (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Mail Stop E-44, Atlanta, GA 30333 USA. EM mhogben@cdc.gov NR 16 TC 7 Z9 7 U1 13 U2 28 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD APR PY 2010 VL 21 IS 4 BP 293 EP 297 DI 10.1258/ijsa.2010.009589 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 599IC UT WOS:000277903600014 PM 20378905 ER PT J AU Inoue, K Kabeya, H Shiratori, H Ueda, K Kosoy, MY Chome, BB Boulouis, HJ Maruyama, S AF Inoue, Kai Kabeya, Hidenori Shiratori, Hatsumi Ueda, Kenji Kosoy, Michael Y. Chome, Bruno B. Boulouis, Henri-Jean Maruyama, Soichi TI Bartonella japonica sp nov and Bartonella silvatica sp nov., isolated from Apodemus mice SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID COMB-NOV; SEQUENCES; CLASSIFICATION; IDENTIFICATION; ROCHALIMAEA; PROPOSALS; HENSELAE; UNIFY AB Two bacterial strains, Fuji 18-1(T) and Fuji 23-1(T), were isolated from the blood of the small Japanese field mouse (Apodemus argenteus) and the large Japanese field mouse (Apodemus speciosus), respectively, specimens of which were captured in the forest of Mount Fuji, Japan. Phenotypic characterization (growth conditions, incubation periods, biochemical properties and cell morphologies), DNA G+C contents (40.1 mol% for strain Fuji 18-1(T) and 40.4 mol% for strain Fuji 23-1T) and sequence analyses of the 16S rRNA genes indicated that both strains were members of the genus Bartonella. Using rpoB and gltA sequencing analysis, the highest sequence similarities between strains Fuji 18-1(T), Fuji 23-1(T) and other recognized species of the genus Bartonella showed values considerably lower than 91.4% and 89.9% in the rpoB gene and 89.1% and 90.4% in the gltA gene, respectively. It is known that similarities of 95.4% for the rpoB gene and 96.0% for the gltA gene can be applied as cut-off values for the designation of novel species of the genus Bartonella. In a phylogenetic tree based on the merged set of concatenated sequences of seven loci [16S rRNA, ftsZ, gltA, groEL, ribC and rpoB genes and the intergenic spacer region (ITS)], strains Fuji 18-1(T) and Fuji 23-1(T) formed a distinct clade from other recognized species of the genus Bartonella. These data support the classification of strains Fuji 18-1(T) and Fuji 23-1T as novel species of the genus Bartonella. The names Bartonella japonica sp. nov. and Bartonella silvatica sp. nov. are proposed for these novel species. The type strains of Bartonella japonica sp. nov. and Bartonella silvatica sp. nov. are Fuji 18-1(T) (=JCM 15567(T)=CIP 109861(T)) and Fuji 23-1(T) (=JCM 15566(T)=CIP 109862(T)), respectively. C1 [Inoue, Kai; Kabeya, Hidenori; Maruyama, Soichi] Nihon Univ, Dept Vet Med, Coll Bioresource Sci, Lab Vet Publ Hlth, Kanagawa 2528510, Japan. [Shiratori, Hatsumi; Ueda, Kenji] Nihon Univ, Life Sci Res Ctr, Coll Bioresource Sci, Kanagawa 2528510, Japan. [Kosoy, Michael Y.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Chome, Bruno B.] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA. [Boulouis, Henri-Jean] Ecole Natl Vet Alfort UVPM, INRA, UMR BIPAR AFSSA, F-94704 Maisons Alfort, France. RP Maruyama, S (reprint author), Nihon Univ, Dept Vet Med, Coll Bioresource Sci, Lab Vet Publ Hlth, 1866 Kameino, Kanagawa 2528510, Japan. EM maroyama.soichi@nihon-u.ac.jp FU Ministry of Education, Culture, Sports, Science and Technology, Japan [20580343] FX This work was supported in part by grants for the Academic Frontier Project 'Surveillance and Control for Zoonoses' and Grant-in-aid for Scientific Research (20580343) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. NR 21 TC 16 Z9 18 U1 0 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD APR PY 2010 VL 60 BP 759 EP 763 DI 10.1099/ijs.0.011528-0 PN 4 PG 5 WC Microbiology SC Microbiology GA 597CK UT WOS:000277733300007 PM 19656930 ER PT J AU Scholz, HC Nockler, K Gollner, C Bahn, P Vergnaud, G Tomaso, H Al Dahouk, S Kampfer, P Cloeckaert, A Maquart, M Zygmunt, MS Whatmore, AM Pfeffer, M Huber, B Busse, HJ De, BK AF Scholz, Holger C. Noeckler, Karsten Goellner, Cornelia Bahn, Peter Vergnaud, Gilles Tomaso, Herbert Al Dahouk, Sascha Kaempfer, Peter Cloeckaert, Axel Maquart, Marianne Zygmunt, Michel S. Whatmore, Adrian M. Pfeffer, Martin Huber, Birgit Busse, Hans-Juergen De, Barun Kumar TI Brucella inopinata sp nov., isolated from a breast implant infection SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID VOLE MICROTUS-ARVALIS; GENOME SEQUENCE; GENETIC DIVERSITY; LIPID-COMPOSITION; MELITENSIS; ABORTUS; STRAINS; DIFFERENTIATION; IDENTIFICATION; GENUS AB A Gram-negative, non-motile, non-spore-forming coccoid bacterium (strain BO1(T)) was isolated recently from a breast implant infection of a 71-year-old female patient with clinical signs of brucellosis. Affiliation of strain BO1(T) to the genus Brucella was confirmed by means of polyamine pattern, polar lipid profile, fatty acid profile, quinone system, DNA DNA hybridization studies and by insertion sequence 711 (IS711)-specific PCR. Strain BO1(T) harboured four to five copies of the Brucella-specific insertion element IS711, displaying a unique banding pattern, and exhibited a unique 16S rRNA gene sequence and also grouped separately in multilocus sequence typing analysis. Strain BO1(T) reacted with Brucella M-monospecific antiserum. Incomplete lysis was detected with bacteriophages Tb (Tbilisi), F1 and F25. Biochemical profiling revealed a high degree of enzymic activity and metabolic capabilities. In multilocus VNTR (variable-number tandem-repeat) analysis, strain BO1(T) showed a very distinctive profile and clustered with the other 'exotic' Brucella strains, including strains isolated from marine mammals, and Brucella microti, Brucella suis biovar 5 and Brucella neotomae. Comparative omp2a and omp2b gene sequence analysis revealed the most divergent omp2 sequences identified to date for a Brucella strain. The recA gene sequence of strain BO1(T) differed in seven nucleotides from the Brucella recA consensus sequence. Using the Brucella species-specific multiplex PCR assay, strain BO1(T) displayed a unique banding pattern not observed in other Brucella species. From the phenotypic and molecular analysis it became evident that strain BO1(T) was clearly different from all other Brucella species, and therefore represents a novel species within the genus Brucella. Because of its unexpected isolation, the name Brucella inopinata with the type strain BO1(T) (=BCCN 09-01(T)=CPAM 6436(T)) is proposed. C1 [Scholz, Holger C.; Tomaso, Herbert; Pfeffer, Martin] Bundeswehr Inst Microbiol, D-80937 Munich, Germany. [Noeckler, Karsten; Goellner, Cornelia; Bahn, Peter] Fed Inst Risk Assessment, D-12277 Berlin, Germany. [Vergnaud, Gilles] DGA D4S Mission Rech & Innovat Sci, F-92220 Bagneux, France. [Vergnaud, Gilles] Univ Paris 11, CNRS, Inst Genet & Microbiol, UMR8621, F-91405 Orsay, France. [Al Dahouk, Sascha] Rhein Westfal TH Aachen, Dept Internal Med 3, D-52074 Aachen, Germany. [Kaempfer, Peter] Univ Giessen, Inst Appl Microbiol, IFZ, D-35392 Giessen, Germany. [Cloeckaert, Axel; Maquart, Marianne; Zygmunt, Michel S.] INRA, UR1282, F-37380 Nouzilly, France. [Whatmore, Adrian M.] Vet Labs Agcy, Addlestone KT15 3NB, Surrey, England. [Huber, Birgit; Busse, Hans-Juergen] Vet Med Univ, Inst Bakteriol Mykol & Hyg, A-1210 Vienna, Austria. [De, Barun Kumar] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Scholz, HC (reprint author), Bundeswehr Inst Microbiol, Neuherbergstr 11, D-80937 Munich, Germany. EM Holger1Scholz@bundeswehr.org RI Whatmore, Adrian/C-7744-2011; APHA, Staff publications/E-6082-2010; Vergnaud, Gilles/P-1304-2015; OI Vergnaud, Gilles/0000-0003-0913-194X; Al Dahouk, Sascha/0000-0003-3835-0818 FU French DGA (Delegation Generale pour l'Armement); European Defence Agency (EDA) FX We are grateful to Csilla Lodri, Stefan Schatz, Robert Schneider, and Angelika Draeger for excellent technical assistance. The development of genotyping methods for the precise strain identification of dangerous pathogens as part of microbial forensics is supported by the French DGA (Delegation Generale pour l'Armement). MRIS and BIM are members of the European Biodefense Laboratory Network (EBLN) supported by the European Defence Agency (EDA). We thank Philippe Le Fleche for the MLVA typing and Mark S Koylass for MLST analysis of strain BO1T. NR 31 TC 113 Z9 118 U1 2 U2 14 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD APR PY 2010 VL 60 BP 801 EP 808 DI 10.1099/ijs.0.011148-0 PN 4 PG 8 WC Microbiology SC Microbiology GA 597CK UT WOS:000277733300015 PM 19661515 ER PT J AU Promadej-Lanier, N Hanson, DL Srinivasan, P Luo, W Adams, DR Guenthner, PC Butera, S Otten, RA Kersh, EN AF Promadej-Lanier, Nattawan Hanson, Debra L. Srinivasan, Priya Luo, Wei Adams, Debra R. Guenthner, Patricia C. Butera, Sal Otten, Ron A. Kersh, Ellen N. TI Resistance to Simian HIV Infection Is Associated With High Plasma Interleukin-8, RANTES and Eotaxin in a Macaque Model of Repeated Virus Challenges SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE animal models; cellular factors/cytokines; chemokines; primate; SIV ID HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 INFECTION; BACTERIAL VAGINOSIS; NONHUMAN-PRIMATES; SUSCEPTIBILITY; AIDS; TRANSMISSION; EXPRESSION; CHEMOKINES; RECEPTORS AB Animal models for research on susceptibility to HIV are currently not available. Here we explore whether a macaque model of repeated low-dose rectal or vaginal virus challenges could be employed. We tested the hypothesis that susceptibility to Simian HIV is not merely stochastic in this model but rather is associated with identifiable host factors. Forty macaques required a median of 3.5 SHIV(SF162P3) challenges for infection. We studied the association of their susceptibility with 13 predisposing plasma cytokines/chemokines (RANTES, Eotaxin, monocyte chemoattractant protein (MCP)-1, IL-7, MIP-1 beta, TNF-alpha, MIP-1 alpha, granulocyte colony-stimulating factor, IL-8, interferon-gamma, IL-17, IL-1 beta, IL-6). Higher plasma RANTES, IL-8, and Eotaxin were associated with lower susceptibility, that is, higher resistance to infection. In a group of macaques with low IL-8 and RANTES, a median 3 exposures were required to infect; whereas, when either IL-8 or RANTES were high, a median 12 exposures were required. Thus, susceptibility was associated with identifiable discrete host factors and was not stochastic. In addition, the macaque model identified key human resistance factors (RANTES, Eotaxin), but also revealed a novel association with resistance (IL-8). Future direct evaluation of these or other factors in the animal model may be beneficial for developing new immunomodulation strategies for HIV prevention. C1 [Promadej-Lanier, Nattawan; Hanson, Debra L.; Srinivasan, Priya; Luo, Wei; Adams, Debra R.; Guenthner, Patricia C.; Butera, Sal; Otten, Ron A.; Kersh, Ellen N.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Kersh, EN (reprint author), 1600 Clifton Rd,Mailstop A25, Atlanta, GA 30333 USA. EM ekersh@cdc.gov FU Centers for Disease Control and Prevention FX Supported by funding from Centers for Disease Control and Prevention. NR 32 TC 10 Z9 10 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR PY 2010 VL 53 IS 5 BP 574 EP 581 DI 10.1097/QAI.0b013e3181d3521f PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 574BZ UT WOS:000275964700003 PM 20164782 ER PT J AU Campsmith, ML Rhodes, PH Hall, HI Green, TA AF Campsmith, Michael L. Rhodes, Philip H. Hall, H. Irene Green, Timothy A. TI Undiagnosed HIV Prevalence Among Adults and Adolescents in the United States at the End of 2006 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE undiagnosed HIV prevalence; risk behaviors; disease disparities ID ANTIRETROVIRAL THERAPY; PREVENTION PROGRAMS; PERSONS AWARE; DRUG-USERS; HIGH-RISK; INFECTION; VIRUS; TRANSMISSION; POPULATION; DIAGNOSES AB Objectives: To describe adults/adolescents (age 13 years and older) living with undiagnosed HIV infection in the United States at the end of 2006. Methods: HIV prevalence and percentage undiagnosed were estimated from cumulative HIV incidence using an extended back-calculation model (using both HIV and AIDS data, the time of first diagnosis with HIV, and disease severity at diagnosis) and estimated cumulative deaths. Results: An estimated 1,106,400 adults/adolescents (95% confidence interval = 1,056,400-1,156,400) were living with HIV in the United States at the end of 2006; overall, 21.0% (232,700; 95% confidence interval = 221,200-244,200) were undiagnosed. Whites had the lowest percentage undiagnosed (18.8%) compared with Hispanics/Latinos (21.6%), blacks/African Americans (22.2%), American Indians/Alaska Natives (25.8%), and Asians/Pacific Islanders (29.5%; all P < 0.001). Persons with a behavioral risk of injection drug use (IDU) had the lowest percentage undiagnosed (female IDU: 13.7% and male IDU: 14.5%); men exposed through heterosexual contact had the highest (26.7%) followed by men who have sex with men (23.5%). Conclusions: Differences in undiagnosed HIV were evident across demographic and behavior groups. Effective testing programs and early access to treatment and prevention services are necessary to reduce undiagnosed HIV infections and HIV prevalence. C1 [Campsmith, Michael L.; Rhodes, Philip H.; Hall, H. Irene; Green, Timothy A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Campsmith, ML (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, MS E-47,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM mcampsmith@cdc.gov NR 46 TC 131 Z9 134 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR PY 2010 VL 53 IS 5 BP 619 EP 624 DI 10.1097/QAI.0b013e3181bf1c45 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 574BZ UT WOS:000275964700009 PM 19838124 ER PT J AU Buchacz, K Baker, RK Young, B Brooks, JT AF Buchacz, Kate Baker, Rose K. Young, Benjamin Brooks, John T. CA HOPS Investigators TI Changes in the Use of HIV Antiretroviral Resistance Testing in a Large Cohort of US Patients, 1999 to 2006 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV susceptibility testing; highly active antiretroviral therapy; prevalence; epidemiology ID DRUG-RESISTANCE; INFECTED PATIENTS; COST-EFFECTIVENESS; THERAPY; RECOMMENDATIONS; DEATH; AIDS; MORTALITY; PANEL; RISK AB Introduction: Monitoring antiretroviral (ARV) drug resistance is of growing importance in the management of persons infected with HIV, but few reports document how genotypic and phenotypic resistance testing (GPT) has been used among patients receiving routine outpatient care. Methods: We studied data from participants in the HIV Outpatient Study seen at 10 HIV clinics in the United States during 1999 to 2006. We restricted analyses to patients whom we considered eligible for GPT (i.e., had a documented HIV viral load > 1000 copies/mL). We used multivariable general modeling to evaluate temporal trends in use of GPT among eligible patients and to identify factors associated with being tested during 1999 to 2002 and 2003 to 2006. Results: Of 5594 active patients, 3995 (71%) were considered eligible for GPT in at least one year during 1999 to 2006 (declining from 50.2% in 1999 to 31.2% in 2006). The fraction of eligible patients receiving GPT increased from 11.2% in 1999 to 31.0% in 2003 (P < 0.001 for trend) and then stabilized at approximately 30% through 2006. Among persons tested, the annual percentage receiving only genotype testing declined over time (90% to 56%), whereas the percentage receiving genotype and phenotype testing increased (5.4% to 39.1%). The annual use of GPT for ARV-naive patients increased over time and after 2003 exceeded the corresponding rates for ARV-experienced patients. In multivariable analyses, low CD4 count and high HIV viral load were consistently associated with GPT. Compared with other ARV-experienced patients, those who were triple ARV-class experienced were consistently more likely to be tested, whereas ARV-naive were less likely to be tested during 1999 to 2002 and more likely during 2003 to 2006. In addition, women and heterosexual men (vs. men who have sex with men) and black patients (vs. white) were less likely to be tested during 1999 to 2002, whereas older patients were less likely to be tested during 2003 to 2006. Discussion: The annual frequency of GPT use has increased almost threefold since 1999. GPTuse among ARV-naive patients has increased coincident with dissemination of recommendations. Although earlier sex and racial/ethnic disparities in testing have waned, older patients were significantly less likely to be tested in recent years. C1 [Buchacz, Kate; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Baker, Rose K.] Cerner Corp, Vienna, VA USA. [Young, Benjamin] Univ Colorado, Rose Med Ctr, Denver, CO 80202 USA. [Young, Benjamin] Univ Colorado, Div Gen Internal Med, Denver, CO 80202 USA. RP Buchacz, K (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE Mail Stop E45, Atlanta, GA 30333 USA. EM acu7@cdc.gov FU Centers for Disease Control and Prevention [200-2001-00133, 200-2006-18797]; Bristol-Myers Squibb Company; Cerner Corporation; Gilead Sciences, GlaxoSmithKline; Hoffman-LaRoche; Merck Co FX Supported by the Centers for Disease Control and Prevention (contract nos. 200-2001-00133 and 200-2006-18797).; B.Y. has received research funding from Bristol-Myers Squibb Company; Cerner Corporation; Gilead Sciences, GlaxoSmithKline; Hoffman-LaRoche; Merck & Co. NR 24 TC 5 Z9 5 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR PY 2010 VL 53 IS 5 BP 625 EP 632 DI 10.1097/QAI.0b013e3181bf1dd2 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 574BZ UT WOS:000275964700010 PM 19841587 ER PT J AU Hoover, KW Tao, GY Berman, S Kent, CK AF Hoover, Karen W. Tao, Guoyu Berman, Stuart Kent, Charlotte K. TI Utilization of Health Services in Physician Offices and Outpatient Clinics by Adolescents and Young Women in the United States: Implications for Improving Access to Reproductive Health Services SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Adolescent; Reproductive health services; Health care utilization patterns ID PELVIC-INFLAMMATORY-DISEASE; DISPARITIES; DELIVERY; QUALITY; VACCINE; ADULTS; RATES AB Purpose: We examined utilization patterns of adolescents and young women as they seek general and reproductive health services in physician offices and hospital outpatient clinics. Methods: We analyzed physician office visits in the 2003-2006 National Ambulatory Medical Care Surveys, and hospital outpatient clinic visits in the National Hospital Ambulatory Medical Care Surveys, to examine utilization patterns of females aged 9-26 years by 2-year age intervals and other characteristics such as physician specialty or clinic type. Results: The number of visits to primary care physician offices increased with age, from 4.9 million for ages 9-10 years to 9.0 million for ages 25-26 years. The proportion of visits made to obstetrician-gynecologists and family practitioners increased with age, and by ages 15-16 years fewer than half of all visits to primary care providers were made to pediatricians. The proportion of visits to family practitioners increased from 25% at ages 9-10 years to 30% at ages 25-26 years. By ages 17-18 years, a larger proportion of visits were made to obstetrician-gynecologists (33% of 7.0 million visits) and to family practitioners (34%) than to pediatricians (23%). The proportion of visits for reproductive health services peaked at 53% of 7.5 million physician visits at ages 20-21 years. Similar utilization patterns were observed for the 11.0 million hospital outpatient visits to primary care providers. Conclusions: Because adolescents and young women most commonly utilize healthcare services provided by obstetrician-gynecologists and family practitioners, these specialties should be priority targets for interventions to improve the quality and availability of reproductive health services. Published by Elsevier Inc. C1 [Hoover, Karen W.; Tao, Guoyu; Berman, Stuart; Kent, Charlotte K.] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Hoover, KW (reprint author), Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,NE MS E-80, Atlanta, GA 30333 USA. EM khoover@cdc.gov NR 32 TC 19 Z9 19 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD APR PY 2010 VL 46 IS 4 BP 324 EP 330 DI 10.1016/j.jadohealth.2009.09.002 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 571VT UT WOS:000275784700004 PM 20307820 ER PT J AU Eaton, DK McKnight-Eily, LR Lowry, R Perry, GS Presley-Cantrell, L Croft, JB AF Eaton, Danice K. McKnight-Eily, Lela R. Lowry, Richard Perry, Geraldine S. Presley-Cantrell, Letitia Croft, Janet B. TI Prevalence of Insufficient, Borderline, and Optimal Hours of Sleep Among High School Students - United States, 2007 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Sleep; High school student; Survey ID CONSEQUENCES; ADOLESCENTS; HEALTH AB We describe the prevalence of insufficient, borderline, and optimal sleep hours among U.S. high school students on an average school night. Most students (68.9%) reported insufficient sleep, whereas few (7.6%) reported optimal sleep. The prevalence of insufficient sleep was highest among female and black students, and students in grades 11 and 12. Published by Elsevier Inc. C1 [Eaton, Danice K.; Lowry, Richard] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [McKnight-Eily, Lela R.; Perry, Geraldine S.; Presley-Cantrell, Letitia; Croft, Janet B.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Eaton, DK (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE,MS K-33, Atlanta, GA 30341 USA. EM dhe0@cdc.gov NR 10 TC 50 Z9 50 U1 1 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD APR PY 2010 VL 46 IS 4 BP 399 EP 401 DI 10.1016/j.jadohealth.2009.10.011 PG 3 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 571VT UT WOS:000275784700016 PM 20307832 ER PT J AU Carroll, DD Blanck, HM Serdula, MK Brown, DR AF Carroll, Dianna D. Blanck, Heidi M. Serdula, Mary K. Brown, David R. TI Obesity, Physical Activity, and Depressive Symptoms in a Cohort of Adults Aged 51 to 61 SO JOURNAL OF AGING AND HEALTH LA English DT Article DE depression; physical activity; obesity; aging ID OLDER-ADULTS; RISK-FACTORS; PREVALENCE; LIFE; PREDICTORS; EXERCISE; MOOD; BIAS; FAT AB Objective: To determine associations between changes in obesity and vigorous physical activity (PA) status and depressive symptoms in a cohort aged 51 to 61 years at baseline. Method: Two waves (1992, 1998) of Health and Retirement Study data were used to divide participants into four obesity and four vigorous PA status categories based on change in or maintenance of their 1992 status in 1998. Depressive symptoms were defined as the upper quintile score (women >= 4, men >= 3) on the eight-item Center for Epidemiologic Studies-Depression Scale. Logistic regression determined adjusted odds ratios for depressive symptoms associated with obesity and vigorous PA status. Results: Among men, no significant associations were found. Among women, decreasing from high vigorous PA status and maintenance of obese status were independently associated with increased odds for depressive symptoms in 1998. Discussion: The findings illustrate the importance of examining gender differences in studies of risk factors for depression. C1 [Carroll, Dianna D.; Blanck, Heidi M.; Serdula, Mary K.; Brown, David R.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Carroll, DD (reprint author), CDC, 4770 Buford Hwy NE MS K-46, Atlanta, GA 30341 USA. EM feu9@cdc.gov RI Weaver, Marissa/C-4027-2012 NR 28 TC 10 Z9 10 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0898-2643 J9 J AGING HEALTH JI J. Aging Health PD APR PY 2010 VL 22 IS 3 BP 384 EP 398 DI 10.1177/0898264309359421 PG 15 WC Gerontology; Health Policy & Services SC Geriatrics & Gerontology; Health Care Sciences & Services GA 567JB UT WOS:000275441800007 PM 20164412 ER PT J AU Stanelle, RD McShane, WJ Dodova, EN Pappas, RS Kobelski, RJ AF Stanelle, Rayman D. McShane, William J. Dodova, Elena N. Pappas, R. Steven Kobelski, Robert J. TI Rapid Analysis of Lewisite Metabolites in Urine by High-Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometry SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID DYNAMIC REACTION CELL; ARSENIC SPECIATION; GAS-CHROMATOGRAPHY; 2-CHLOROVINYLARSONOUS ACID; DEGRADATION-PRODUCTS; QUALITY-CONTROL; WARFARE AGENTS; EXPOSURE; SELENIUM C1 [Stanelle, Rayman D.; Pappas, R. Steven; Kobelski, Robert J.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [McShane, William J.] Battelle Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA. [Dodova, Elena N.] Battelle Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Stanelle, RD (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F-44, Atlanta, GA 30341 USA. EM fmk9@cdc.gov NR 40 TC 6 Z9 9 U1 0 U2 3 PU PRESTON PUBL INC PI NILES PA 6600 W TOUHY AVE, NILES, IL 60714-4588 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD APR PY 2010 VL 34 IS 3 BP 122 EP 128 PG 7 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 581OA UT WOS:000276532200002 PM 20406535 ER PT J AU Schier, JG Heninger, M Wolkin, A Kieszak, S Caldwell, KL Fajardo, GC Jones, R Rubin, C Hanzlick, R Osterloh, JD McGeehin, MA AF Schier, Joshua G. Heninger, Michael Wolkin, Amy Kieszak, Stephanie Caldwell, Kathleen L. Fajardo, Geroncio C. Jones, Robert Rubin, Carol Hanzlick, Randy Osterloh, John D. McGeehin, Michael A. TI Postmortem Blood Cadmium, Lead, and Mercury Concentrations: Comparisons with Regard to Sampling Location and Reference Ranges for Living Persons SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID PLASMA-MASS SPECTROMETRY; DRUG REDISTRIBUTION; WHOLE-BLOOD; TISSUES; URINE C1 [Schier, Joshua G.; Wolkin, Amy; Kieszak, Stephanie; Rubin, Carol; McGeehin, Michael A.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Heninger, Michael; Fajardo, Geroncio C.; Hanzlick, Randy] Fulton Cty Med Examiners Off, Atlanta, GA USA. [Caldwell, Kathleen L.; Jones, Robert; Osterloh, John D.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Schier, JG (reprint author), Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. RI Jones, Robert/E-1170-2011; Schier, Joshua/F-9861-2013 NR 23 TC 1 Z9 2 U1 0 U2 0 PU PRESTON PUBL INC PI NILES PA 6600 W TOUHY AVE, NILES, IL 60714-4588 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD APR PY 2010 VL 34 IS 3 BP 129 EP 134 PG 6 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 581OA UT WOS:000276532200003 PM 20406536 ER PT J AU Ziemer, CJ Bonner, JM Cole, D Vinje, J Constantini, V Goyal, S Gramer, M Mackie, R Meng, XJ Myers, G Saif, LJ AF Ziemer, C. J. Bonner, J. M. Cole, D. Vinje, J. Constantini, V. Goyal, S. Gramer, M. Mackie, R. Meng, X. J. Myers, G. Saif, L. J. TI Fate and transport of zoonotic, bacterial, viral, and parasitic pathogens during swine manure treatment, storage, and land application SO JOURNAL OF ANIMAL SCIENCE LA English DT Article; Proceedings Paper CT Beef Symposium on Population Data Analyses to Evaluate Trends in Animal Production Systems CY JUL 12-16, 2009 CL Montreal, CANADA SP Amer Soc Anim Sci, Amer Dairy Sci Assoc, Canadian Soc Anim Sci DE manure application; manure storage; manure treatment; swine manure; zoonotic pathogen ID HEPATITIS-E VIRUS; INFLUENZA-A VIRUSES; ESCHERICHIA-COLI; UNITED-STATES; YERSINIA-ENTEROCOLITICA; GIARDIA-INTESTINALIS; PORCINE ROTAVIRUSES; ASCARIS-SUUM; MOLECULAR CHARACTERIZATION; MICROBIAL-POPULATIONS AB Members of the public are always somewhat aware of foodborne and other zoonotic pathogens; however, recent illnesses traced to produce and the emergence of pandemic H1N1 influenza virus have increased the scrutiny on all areas of food production. The Council for Agricultural Science and Technology has recently published a comprehensive review of the fate and transport of zoonotic pathogens that can be associated with swine manure. The majority of microbes in swine manure are not zoonotic, but several bacterial, viral, and parasitic pathogens have been detected. Awareness of the potential zoonotic pathogens in swine manure and how treatment, storage, and handling affect their survival and their potential to persist in the environment is critical to ensure that producers and consumers are not at risk. This review discusses the primary zoonotic pathogens associated with swine manure, including bacteria, viruses, and parasites, as well as their fate and transport. Because the ecology of microbes in swine waste is still poorly described, several recommendations for future research are made to better understand and reduce human health risks. These recommendations include examination of environmental and ecological conditions that contribute to off-farm transport and development of quantitative risk assessments. C1 [Ziemer, C. J.] USDA ARS, Natl Lab Agr & Environm, Ames, IA 50011 USA. [Bonner, J. M.] Council Agr Sci & Technol, Ames, IA 50014 USA. [Cole, D.] Georgia Div Publ Hlth, Atlanta, GA 30303 USA. [Vinje, J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Constantini, V.] Ohio State Univ, Wooster, OH 44691 USA. [Goyal, S.; Gramer, M.] Univ Minnesota, St Paul, MN 55108 USA. [Mackie, R.] Univ Illinois, Champaign, IL 61820 USA. [Meng, X. J.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. [Myers, G.] Myers Parasitol Serv, Magnolia, KY 42757 USA. [Saif, L. J.] Ohio State Univ, Columbus, OH 43210 USA. RP Ziemer, CJ (reprint author), USDA ARS, Natl Lab Agr & Environm, Ames, IA 50011 USA. EM cherie.ziemer@ars.usda.gov RI Meng, X.J./B-8769-2009; OI Meng, X.J./0000-0002-2739-1334; Vinje, Jan/0000-0002-1530-3675; Costantini, Veronica/0000-0002-1532-4345 NR 128 TC 26 Z9 26 U1 4 U2 28 PU AMER SOC ANIMAL SCIENCE PI CHAMPAIGN PA 2441 VILLAGE GREEN PLACE, CHAMPAIGN, IL 61822 USA SN 0021-8812 J9 J ANIM SCI JI J. Anim. Sci. PD APR PY 2010 VL 88 SU 13 BP E84 EP E94 DI 10.2527/jas.2009-2331 PG 11 WC Agriculture, Dairy & Animal Science SC Agriculture GA 585FY UT WOS:000276811200013 PM 20348375 ER PT J AU Anger, HA Dworkin, F Sharma, S Munsiff, SS Nilsen, DM Ahuja, SD AF Anger, Holly A. Dworkin, Felicia Sharma, Saarika Munsiff, Sonal S. Nilsen, Diana M. Ahuja, Shama D. TI Linezolid use for treatment of multidrug-resistant and extensively drug-resistant tuberculosis, New York City, 2000-06 SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE MDR TB; XDR TB; oxazolidinones; toxicity; outcomes ID PERIPHERAL NEUROPATHY; TOLERABILITY; EFFICACY; SAFETY AB Linezolid may be effective for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB); however, serious adverse events are common and there is little information on the management of these toxicities. We retrospectively reviewed public health and medical records of 16 MDR TB patients, including 10 patients with XDR TB, who were treated with linezolid in New York City between January 2000 and December 2006, to determine treatment outcomes and describe the incidence, management and predictors of adverse events. Linezolid was added to MDR TB regimens for a median duration of 16 months (range: 1-29). Eleven patients (69%) completed treatment, four (25%) died and one (6%) discontinued treatment without relapse. Myelosuppression occurred in 13 (81%) patients a median of 5 weeks (range: 1-11) after starting linezolid, gastrointestinal adverse events occurred in 13 (81%) patients after a median of 8 weeks (range: 1-57) and neurotoxicity occurred in seven (44%) patients after a median of 16 weeks (range: 10-111). Adverse events were managed by combinations of temporary suspension of linezolid, linezolid dose reduction and symptom management. Five (31%) patients required eventual discontinuation of linezolid. Myelosuppression was more responsive to clinical management strategies than was neurotoxicity. Leucopenia and neuropathy occurred more often in males and older age was associated with thrombocytopenia (P < 0.05). The majority of MDR TB patients on linezolid had favourable treatment outcomes, although treatment was complicated by adverse events that required extensive clinical management. C1 [Anger, Holly A.; Dworkin, Felicia; Sharma, Saarika; Munsiff, Sonal S.; Nilsen, Diana M.; Ahuja, Shama D.] Bur TB Control, New York City Dept Hlth & Mental Hyg, New York, NY 10007 USA. [Munsiff, Sonal S.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. RP Anger, HA (reprint author), Bur TB Control, New York City Dept Hlth & Mental Hyg, 225 Broadway,22nd Floor, New York, NY 10007 USA. EM hanger@health.nyc.gov OI Nilsen, Diana/0000-0001-7031-6615 FU New York City Department of Health and Mental Hygiene Bureau of Tuberculosis Control FX This work was supported by New York City Department of Health and Mental Hygiene Bureau of Tuberculosis Control programme funds. NR 20 TC 53 Z9 62 U1 0 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD APR PY 2010 VL 65 IS 4 BP 775 EP 783 DI 10.1093/jac/dkq017 PG 9 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 569AT UT WOS:000275569000028 PM 20150181 ER PT J AU Autry, AR Trevathan, E Braun, KV Yeargin-Allsopp, M AF Autry, Andrew R. Trevathan, Edwin Braun, Kim Van Naarden Yeargin-Allsopp, Marshalyn TI Increased Risk of Death Among Children With Lennox-Gastaut Syndrome and Infantile Spasms SO JOURNAL OF CHILD NEUROLOGY LA English DT Article DE Lennox-Gastaut syndrome; infantile spasms; mortality; epilepsy ID ATLANTA DEVELOPMENTAL-DISABILITIES; DESCRIPTIVE EPIDEMIOLOGY; EPILEPSY; MORTALITY; PREVALENCE; CHILDHOOD AB The magnitude and causes of death among a cohort of children with epilepsy were determined. A follow-up study with a population-based cohort of 10-year-old children in the metropolitan Atlanta area with epilepsy was conducted. The National Death Index and linkage to State of Georgia death certificates were used to identify deaths. The authors estimated the expected numbers of deaths by applying mortality rates adjusted by age, race, and sex for the entire state of Georgia to the population for the follow-up period. Among the 688 children who were in the final epilepsy cohort, 64 deaths occurred; 20.6 deaths were expected (mortality ratio adjusted for age, race, and sex = 3.11). The mortality ratios for children with Lennox-Gastaut syndrome and infantile spasms were 13.92 and 11.91, respectively. Children and adolescents with epilepsy, especially those with Lennox-Gastaut syndrome or infantile spasms, have an increased risk of death. C1 [Autry, Andrew R.; Trevathan, Edwin; Braun, Kim Van Naarden; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Trevathan, Edwin] Washington Univ, St Louis Sch Med, Div Pediat & Dev Neurol, Dept Neurol, St Louis, MO USA. [Trevathan, Edwin] Washington Univ, Dept Pediat, St Louis Sch Med, Div Pediat & Dev Neurol, St Louis, MO 63130 USA. RP Trevathan, E (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,NE,Mailstop E-87, Atlanta, GA 30333 USA. EM ETrevathan@cdc.gov FU Washington University in St Louis [03-IPA05200]; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC) [03-IPA05200]; Alexander C. Graebe Memorial Fund; Jason Sears and Edy Sumner Memorial Fund FX The authors disclosed receipt of the following financial support for the research and/or authorship of this article: Dr Trevathan was supported in part by an Interagency Personnel Agreement (03-IPA05200) between Washington University in St Louis and the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), and by the Alexander C. Graebe Memorial Fund and the Jason Sears and Edy Sumner Memorial Fund. NR 20 TC 16 Z9 16 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0883-0738 J9 J CHILD NEUROL JI J. Child Neurol. PD APR PY 2010 VL 25 IS 4 BP 441 EP 447 DI 10.1177/0883073809348355 PG 7 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 579HU UT WOS:000276360400006 PM 20023065 ER PT J AU Sofair, AN Barry, V Manos, MM Thomas, A Zaman, A Terrault, NA Murphy, RC Stabach, N Huie, S Van Ness, G Bell, BP Bialek, S AF Sofair, Andre N. Barry, Vaughn Manos, M. Michele Thomas, Ann Zaman, Atif Terrault, Norah A. Murphy, Rosemary C. Stabach, Nicole Huie, Sharon Van Ness, Grace Bell, Beth P. Bialek, Stephanie TI The Epidemiology and Clinical Characteristics of Patients With Newly Diagnosed Alcohol-related Liver Disease Results From Population-based Surveillance SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE ethanol; fibrosis; liver diseases; epidemiology; population surveillance ID CHRONIC HEPATITIS-C; HISTOLOGICAL LESIONS; DRINKING PATTERNS; DOSE-RESPONSE; UNITED-STATES; VIRUS-RNA; CONSUMPTION; CIRRHOSIS; HISTORY; SEX AB Goals: We describe the epidemiology of outpatients newly diagnosed with chronic alcoholic liver disease and describe predictors of cirrhosis and referral for specialty care. Background: Alcohol is a major cause of liver disease in the United States. Most previous work has described hospitalized patients. Study: Participants were identified through prospective population-based surveillance in gastroenterology practices Multnomah County, Oregon and New Haven County, Connecticut; and primary care and gastroenterology practices from Kaiser Permanente Northern California in Alameda County during 1999 to 2001. Patients were interviewed, a blood specimen obtained, and their medical record reviewed. Results: We identified 82 patients from gastroenterology practices with newly diagnosed alcoholic liver disease. Their median age was 50.0 years. 72.0% were male and 79.3% were White. The median age at initiation of alcohol use was 17.0 years. 43.9% of patients had evidence of cirrhosis at the time of diagnosis. Only 40.2% reported alcohol as the cause of their liver disease. Patients with cirrhosis were more likely to be older, have a higher median number of years of heavy alcohol consumption, and to have been hospitalized for a liver-related complication than noncirrhotic patients. An additional 83 primary care patients were more likely to be older, to be drinking alcohol at study interview, and to not have cirrhosis than patients referred for gastroenterology care. Conclusions: Patients with alcoholic liver disease may present at a late stage and may not identify alcohol as a cause for their liver disease. Improved patient screening and education may limit morbidity and mortality. C1 [Sofair, Andre N.; Stabach, Nicole; Huie, Sharon] Yale Univ, Sch Med, New Haven, CT USA. [Barry, Vaughn; Bell, Beth P.; Bialek, Stephanie] Ctr Dis Control & Prevent, Atlanta, GA USA. [Manos, M. Michele] Kaiser Permanente, Div Res, Oakland, CA USA. [Terrault, Norah A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Thomas, Ann; Murphy, Rosemary C.; Van Ness, Grace] Oregon Hlth & Sci Univ, Oregon Publ Hlth Div, Portland, OR 97201 USA. [Zaman, Atif] Oregon Hlth & Sci Univ, Div Gastroenterol & Hepatol, Portland, OR 97201 USA. RP Sofair, AN (reprint author), Waterbury Hosp & Hlth Ctr, Dept Med, 3rd Floor,64 Robbins St, Waterbury, CT 06721 USA. EM andre.sofair@yale.edu FU Centers for Disease Control and Prevention FX Funding Source: Centers for Disease Control and Prevention. NR 33 TC 8 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD APR PY 2010 VL 44 IS 4 BP 301 EP 307 DI 10.1097/MCG.0b013e3181b3f760 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 577BV UT WOS:000276196800017 PM 19745759 ER PT J AU Toblin, RL Paulozzi, LJ Logan, JE Hall, AJ Kaplan, JA AF Toblin, Robin L. Paulozzi, Leonard J. Logan, Joseph E. Hall, Aron J. Kaplan, James A. TI Mental Illness and Psychotropic Drug Use Among Prescription Drug Overdose Deaths: A Medical Examiner Chart Review SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID NATIONAL EPIDEMIOLOGIC SURVEY; ANXIETY DISORDERS; UNITED-STATES; PRIMARY-CARE; COMORBIDITY; PREVALENCE; ALCOHOL; ASSOCIATION; ABUSE; PAIN AB Objective: Between 1999 and 2006, there was a 120% increase in the rate of unintentional drug overdose deaths in the United States. This study identifies the prevalence of mental illness, a risk factor for substance abuse, and chronic pain among prescription drug overdose deaths in West Virginia and ascertains whether psychotropic drugs contributing to the deaths were used to treat mental illness or for nonmedical purposes. Method: In 2007, we abstracted data on mental illness, pain, and drugs contributing to death from all unintentional prescription drug overdose deaths in 2006 recorded by the West Virginia Office of the Chief Medical Examiner. Decedent prescription records were obtained from the state prescription drug monitoring program. Results: Histories of mental illness and pain were documented in 42.7% and 56.6% of 295 decedents, respectively. Psychotropic drugs contributed to 48.8% of the deaths, with benzodiazepines involved in 36.6%. Benzodiazepines contributing to death were not associated with mental illness (adjusted odds ratio [AOR] =1.1; 95% CI, 0.6-1.8), while all other psychotropic drugs were (AOR = 3.9; 95% CI, 2.0-7.6). Of decedents with contributory benzodiazepines, 46.3% had no prescription for the drug. Conclusions: Mental illness may have contributed to substance abuse associated with deaths. Clinicians should screen for mental illness when prescribing opioids and recommend psychotherapy as an adjunct or an alternate to pharmacotherapy. Benzodiazepines may have been used nonmedically rather than as a psychotropic drug, reflecting drug diversion. Restricting benzodiazepine prescriptions to a 30-day supply with no refills might be considered. J Clin Psychiatry 2010;71(4):491-496 (C) Copyright 2010 Physicians Postgraduate Press, Inc. C1 [Toblin, Robin L.; Logan, Joseph E.; Hall, Aron J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Toblin, Robin L.; Paulozzi, Leonard J.; Logan, Joseph E.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Hall, Aron J.; Kaplan, James A.] W Virginia Dept Hlth & Human Resources, Charleston, WV USA. RP Toblin, RL (reprint author), Fed Bur Prisons, Off Res & Evaluat, 320 1st St NW, Washington, DC 20534 USA. EM rtoblin@bop.gov NR 25 TC 50 Z9 50 U1 0 U2 2 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD APR PY 2010 VL 71 IS 4 BP 491 EP 496 DI 10.4088/JCP.09m05567blu PG 6 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 588HI UT WOS:000277059300014 PM 20409446 ER PT J AU Elmore, K Flanagan, B Jones, NF Heitgerd, JL AF Elmore, Kim Flanagan, Barry Jones, Nicholas F. Heitgerd, Janet L. TI Leveraging Geospatial Data, Technology, and Methods for Improving the Health of Communities: Priorities and Strategies from an Expert Panel Convened by the CDC SO JOURNAL OF COMMUNITY HEALTH LA English DT Article DE Healthy communities; Geospatial; GIS ID GEOGRAPHIC INFORMATION-SYSTEMS; BUILT ENVIRONMENT; PUBLIC-HEALTH AB In 2008, CDC convened an expert panel to gather input on the use of geospatial science in surveillance, research and program activities focused on CDC's Healthy Communities Goal. The panel suggested six priorities: spatially enable and strengthen public health surveillance infrastructure; develop metrics for geospatial categorization of community health and health inequity; evaluate the feasibility and validity of standard metrics of community health and health inequities; support and develop GIScience and geospatial analysis; provide geospatial capacity building, training and education; and, engage non-traditional partners. Following the meeting, the strategies and action items suggested by the expert panel were reviewed by a CDC subcommittee to determine priorities relative to ongoing CDC geospatial activities, recognizing that many activities may need to occur either in parallel, or occur multiple times across phases. Phase A of the action items centers on developing leadership support. Phase B focuses on developing internal and external capacity in both physical (e.g., software and hardware) and intellectual infrastructure. Phase C of the action items plan concerns the development and integration of geospatial methods. In summary, the panel members provided critical input to the development of CDC's strategic thinking on integrating geospatial methods and research issues across program efforts in support of its Healthy Communities Goal. C1 [Elmore, Kim] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Flanagan, Barry] CDC, Agcy Tox Subst & Dis Registry, Chamblee, GA 30341 USA. [Jones, Nicholas F.] CDC, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Heitgerd, Janet L.] CDC, Off Crit Informat Integrat & Exchange, Atlanta, GA 30333 USA. RP Elmore, K (reprint author), CDC, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS E-48, Atlanta, GA 30333 USA. EM kelmore@cdc.gov NR 27 TC 1 Z9 1 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0094-5145 J9 J COMMUN HEALTH JI J. Community Health PD APR PY 2010 VL 35 IS 2 BP 165 EP 171 DI 10.1007/s10900-009-9210-4 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 586DE UT WOS:000276881000007 PM 20012474 ER PT J AU Kochtitzky, C AF Kochtitzky, Chris TI Approaching a Perfect Storm: Responding to New Challenges Without Losing Critical Core Capacities SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material AB Editor's Note: NEHA strives to provide up-to-date and relevant information on environmental health and to build partnerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Control and Prevention (CDC) in every issue of the Journal. In this column, EHSB and guest authors from across CDC will highlight a variety of concerns, opportunities, challenges, and successes that we all share in environmental public health. EHSB's objective is to strengthen the role of state, local, and national environmental health programs and professionals to anticipate, identify, and respond to adverse environmental exposures and the consequences of these exposures for human health. The services being developed through EHSB include access to topical, relevant, and scientific information; consultation; and assistance to environmental health specialists, sanitarians, and environmental health professionals and practitioners. The conclusions in this article are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention. Chris Kochtitzky is an urban planner by training specializing in environmental planning and is currently the deputy director (acting) of CDC's Division of Emergency and Environmental Health Services. He holds an MS in planning from Florida State University. C1 CDC, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Kochtitzky, C (reprint author), CDC, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-60, Atlanta, GA 30341 USA. EM csk3@cdc.gov NR 11 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD APR PY 2010 VL 72 IS 8 BP 30 EP 33 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 581PG UT WOS:000276535700006 PM 20420052 ER PT J AU Liao, Y Tucker, P Siegel, P Liburd, L Giles, WH AF Liao, Y. Tucker, P. Siegel, P. Liburd, L. Giles, W. H. CA REACH 2010 Investigators TI Decreasing disparity in cholesterol screening in minority communities-findings from the Racial and Ethnic Approaches to Community Health 2010 SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH LA English DT Article ID CARDIOVASCULAR-DISEASE RISK; HIGH BLOOD CHOLESTEROL; EDUCATION-PROGRAM; AFRICAN-AMERICAN; EXPERT PANEL; SOCIOECONOMIC-STATUS; PROMOTION; ADULTS; HEART; INTERVENTION AB Background Highly controlled research projects demonstrated success in preventing and controlling cardiovascular diseases. Community-based programs have yet to demonstrate significant influence. Data on large-scale community-level interventions targeting minority communities are limited. The aim of this study is to measure the impact of the Racial and Ethnic Approaches to Community Health ( REACH 2010) project, a community-based intervention to eliminate racial/ethnic disparities in blood cholesterol screening in minority communities. Methods Annual survey data from 2001 to 2006 were gathered in 22 communities. Trends in the prevalence of age-standardised blood cholesterol screening were examined for four racial/ethnic groups ( black, Hispanic, Asian and American Indian/Alaska Native), stratified by education level, and compared with national data from the Behavioral Risk Factor Surveillance System. Results The prevalence of cholesterol screening increased among persons in black, Hispanic and Asian REACH communities (p<0.001), whereas prevalence decreased in the total US and Hispanic populations (p<0.001) and remained similar among blacks and Asians nationwide. The relative disparity between the total US population and most REACH communities decreased (p<0.05). Relative disparity in cholesterol screening related to education level decreased (p<0.05) within REACH communities, whereas relative disparity related to education level nationwide remained similar in blacks and increased (p<0.001) in Hispanics. Conclusion The REACH project decreased racial and ethnic disparities in cholesterol screening between REACH communities and the total US population, as well as disparities related to education level within REACH communities. C1 [Liao, Y.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Liao, Y (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,K-30, Atlanta, GA 30341 USA. EM Ycl1@cdc.gov NR 46 TC 7 Z9 7 U1 1 U2 5 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0143-005X J9 J EPIDEMIOL COMMUN H JI J. Epidemiol. Community Health PD APR PY 2010 VL 64 IS 4 BP 292 EP 299 DI 10.1136/jech.2008.084061 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 574ZN UT WOS:000276032900004 PM 19666632 ER PT J AU Donahue, K Plescia, M Stafford, K AF Donahue, Katrina Plescia, Marcus Stafford, Karen TI Do standing orders help with chronic disease care and health maintenance in ambulatory practice? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID VACCINATION PROGRAM; INFLUENZA VACCINE; IMMUNIZATION; SERVICES; ADULT C1 [Donahue, Katrina] Univ N Carolina, Dept Family Med, Chapel Hill, NC 27514 USA. [Plescia, Marcus] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Stafford, Karen] Univ N Carolina, Hlth Sci Lib, Chapel Hill, NC 27514 USA. RP Donahue, K (reprint author), Univ N Carolina, Dept Family Med, Chapel Hill, NC 27514 USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD APR PY 2010 VL 59 IS 4 BP 226 EP 227 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 796XE UT WOS:000293086000010 PM 20398582 ER PT J AU Kim, WR Ward, JW Cheever, LW Dan, C Dee, L Zola, J AF Kim, W. Ray Ward, John W. Cheever, Laura W. Dan, Corinna Dee, Lynda Zola, Janet TI Transforming the current infrastructure for combating HBV and HCV infections SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID HEPATITIS-C; UNITED-STATES; HEALTH-CARE; VIRUS C1 [Kim, W. Ray] Mayo Clin, Coll Med, Rochester, MN 55905 USA. [Ward, John W.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA USA. [Cheever, Laura W.] Hlth Resources & Serv Adm, HIV AIDS Bur, Rockville, MD USA. [Dan, Corinna] AAPCHO, Oakland, CA USA. [Dee, Lynda] Maryland Hepatitis Coalit, Baltimore, MD USA. [Zola, Janet] San Francisco Dept Publ Hlth, San Francisco, CA USA. RP Kim, WR (reprint author), Mayo Clin, Coll Med, Rochester, MN 55905 USA. FU Romark FX Dr Kim reports the following: Consultant: Bristol-Myers Squibb, Gilead Sciences Inc., Roche Pharmaceuticals. Grant/Research Support: Romark NR 18 TC 1 Z9 1 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD APR PY 2010 VL 59 IS 4 SU S BP S65 EP S70 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 796XH UT WOS:000293086300010 PM 20398593 ER PT J AU Peters, MG Weinbaum, C Tan, L Baine, WB Dienstag, JL Liang, TJ So, S AF Peters, Marion G. Weinbaum, Cindy Tan, Litjen (L. J.) Baine, William B. Dienstag, Jules L. Liang, T. Jake So, Samuel TI Recommendations for prevention, screening, and diagnosis of HBV and HCV infections SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID C VIRUS-INFECTION; HEPATITIS-C; UNITED-STATES; MANAGEMENT; UPDATE C1 [Peters, Marion G.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Weinbaum, Cindy] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Tan, Litjen (L. J.)] Amer Med Assoc, Chicago, IL 60610 USA. [Baine, William B.] Agcy Healthcare Res & Qual AHRQ, Rockville, MD USA. [Dienstag, Jules L.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Dienstag, Jules L.] Harvard Univ, Sch Med, Boston, MA USA. [Liang, T. Jake] Amer Assoc Study Liver Dis AASLD, Alexandria, VA USA. [So, Samuel] Stanford Univ, Sch Med, Stanford, CA 94305 USA. RP Peters, MG (reprint author), Univ Calif San Francisco, San Francisco, CA 94143 USA. FU Genentech; NIDDK; Vertex FX Dr Peters reports the following: Consultant: Clinical Care Options, Genentech, Pharmasset. Salary: Dr Peters' spouse receives a salary from Genentech; Dr Dienstag reports the following: Consultant: Abbott Molecular, Boehringer Ingelheim, Bristol-Myers Squibb, Genzyme, Human Genome Sciences, Medtronic, Schering-Plough Research Institute. Grant/Research Support: NIDDK, Vertex. Ownership Interest: Options: Achillion, Metabasis, Nucleonics NR 23 TC 1 Z9 1 U1 0 U2 1 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD APR PY 2010 VL 59 IS 4 SU S BP S29 EP S35 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 796XH UT WOS:000293086300005 PM 20398588 ER PT J AU Ward, JW Hu, DJ Alter, MJ Kanwal, F Taylor, C Block, JM Caballero, JB Chase, D Saly, M Sandt, L Swan, T AF Ward, John W. Hu, Dale J. Alter, Miriam J. Kanwal, Fasiha Taylor, Chris Block, Joan M. Caballero, Jeffrey B. Chase, Denton Saly, Martha Sandt, Lorren Swan, Tracy TI Transforming strategies for the prevention of chronic HBV and HCV infections SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID HEPATITIS-C VIRUS; INJECTION-DRUG USERS; UNITED-STATES; B-VIRUS; VIRAL-HEPATITIS; PREVALENCE; CARE; TRANSMISSION; PROJECT C1 [Ward, John W.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Hu, Dale J.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Epidemiol & Surveillance Branch, Atlanta, GA USA. [Alter, Miriam J.] Univ Texas Galveston, Med Branch, Inst Human Infect & Immun, Infect Dis Epidemiol Program, Galveston, TX 77550 USA. [Kanwal, Fasiha] St Louis Univ, Sch Med, John Cochran VA Med Ctr, Dept Gastroenterol & Hepatol, St Louis, MO USA. [Block, Joan M.] Hepatitis B Fdn, Doylestown, PA USA. [Caballero, Jeffrey B.] AAPCHO, Oakland, CA USA. [Chase, Denton] Asian Hlth Commun, Parsippany, NJ USA. [Saly, Martha] Natl Viral Hepatitis Roundtable, Rohnert Pk, CA USA. [Sandt, Lorren] Caring Ambassadors Program Inc, Oregon City, OR USA. [Swan, Tracy] Treatment Action Grp, New York, NY USA. RP Ward, JW (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 23 TC 2 Z9 2 U1 1 U2 2 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD APR PY 2010 VL 59 IS 4 SU S BP S23 EP S28 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 796XH UT WOS:000293086300004 PM 20398587 ER PT J AU Breuer, J Grose, C Norberg, P Tipples, G Schmid, DS AF Breuer, Judith Grose, Charles Norberg, Peter Tipples, Graham Schmid, D. Scott TI A proposal for a common nomenclature for viral clades that form the species varicella-zoster virus: summary of VZV Nomenclature Meeting 2008, Barts and the London School of Medicine and Dentistry, 24-25 July 2008 SO JOURNAL OF GENERAL VIROLOGY LA English DT Review ID SINGLE-NUCLEOTIDE POLYMORPHISMS; COMPLETE DNA-SEQUENCES; HERPES-ZOSTER; MOLECULAR EPIDEMIOLOGY; PHYLOGENETIC ANALYSIS; HUMAN GENOME; EAST LONDON; LONG-TERM; IDENTIFICATION; GENOTYPES AB Varicella-zoster virus (VZV), the cause of chickenpox and zoster, was the first human herpesvirus to be sequenced fully and the first for which vaccines have been licensed and widely used. Three groups have published genotyping schemes based on single nucleotide polymorphisms (SNPs) and, between them, have identified five distinct phylogenetic clades, with an additional two putative clades. Sequencing of over 23 whole VZV genomes from around the world further refined the phylogenetic distinctions between SNP genotypes. Widespread surveillance in countries in which the varicella vaccine is now in use and the difficulties posed by three unique genotyping approaches prompted an international meeting, at which a common nomenclature based on phylogenetic clades was agreed upon. In this paper, we review the original genotyping schemes and discuss the basis for a novel common nomenclature for VZV strains. We propose a minimum set of SNPs that we recommend should be used to genotype these viruses. Finally, we suggest criteria by which novel clades can be recognized. C1 [Breuer, Judith] UCL, Windeyer Inst, Div Infect & Immun, London WC1 4JF, England. [Grose, Charles] Univ Iowa, Childrens Hosp, Virol Lab, Iowa City, IA 52242 USA. [Norberg, Peter] Univ Gothenburg, Dept Cell & Mol Biol, S-40530 Gothenburg, Sweden. [Tipples, Graham] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. [Schmid, D. Scott] Ctr Dis Control & Prevent CDC, Natl Ctr Immunizat & Resp Dis NCID, Div Viral Dis, Atlanta, GA 30333 USA. RP Breuer, J (reprint author), UCL, Windeyer Inst, Div Infect & Immun, 46 Cleveland St, London WC1 4JF, England. EM j.breuer@ucl.ac.uk OI Breuer, Judith/0000-0001-8246-0534 FU NIH [AI22785]; office of the Chief Scientist, Health Canada; Barts; London Special Trustees; UCLH Collaborative Biomedical Research Centre FX We all acknowledge the importance of the initial VZV sequence analysis by A. Davison. Research by C. G. was supported by NIH grant AI22785. Research by G. T. was supported by a grant from the office of the Chief Scientist, Health Canada. Research by J. B. was supported by a grant from Barts and the London Special Trustees. J. B. is supported by UCLH Collaborative Biomedical Research Centre. Thanks also to the following who attended the 2008 VZV Nomenclature Meeting, Whitechapel, London, UK: Karin T. Averbeck, Inga Dry, Suzanna L. R. McDonald, Mark Quinlivan, Nitu Sengupta (Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, and the London School of Medicine and Dentistry, Queen Mary College, London El 2AT, UK), Tomas Bergstrom (Department of Clinical Virology, Goteborg University, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden), Vanda Bostik, Jane F. Seward (Division of Viral Diseases, NCID, CDC, Atlanta, GA 30333, USA), David Brown, Kevin Brown (Centre for Infection, Health Protection Agency, 61 Colindale Ave, London NW9 5EQ, UK), Randall J. Cohrs (Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, USA), Ruth Harbecke, Michael N. Oxman (VA San Diego Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161-0002, USA) and Richard A. Nichols (School of Biological and Chemical Sciences, Queen Mary University of London, London, UK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the funding agencies. NR 43 TC 49 Z9 57 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD APR PY 2010 VL 91 BP 821 EP 828 DI 10.1099/vir.0.017814-0 PN 4 PG 8 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 583XR UT WOS:000276714300001 PM 20071486 ER PT J AU Hu, SHS Pallonen, UE Meshack, AF AF Hu, Shaohua S. Pallonen, Unto E. Meshack, Angela F. TI The Impact of Immigration Status on Tobacco Use among Chinese-American Adults in Texas SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Immigration; Chinese-American; Surveys; Tobacco use ID ASIAN-AMERICANS; SMOKING-CESSATION; PACIFIC-ISLANDERS; ACCULTURATION; PREVALENCE AB Objectives This study analyzed the impact of immigration status on current tobacco use among adult Chinese-Americans living in Texas. Methods A survey was administered in Chinese and English in 2004 to assess tobacco use among Chinese-American adults using a stratified probability sample from two large metropolitan areas in Texas. Data were adjusted for unequal probability of selection and weighted to provide state-wide estimates for Chinese-Americans in Texas. Results The study sample was comprised of 1,054 Chinese-American adults. The overall current smoking rate was 11.1% with men's rates much higher (16.1%) than women's (6.7%). Lower household income and education increased smoking among males but more educated females had a tendency to smoke more. Although overall smoking rate among Chinese-Americans was significantly lower than the general Texas population (20.6%), smoking rate among recent immigrant men (<5 years in the U.S.) was alarmingly higher (28.0%). U.S.-born Chinese-American men's smoking rate (25.0%) is similar to that of their U.S.-born counterparts (23.7%). U.S.-born Chinese-American men initiated smoking 4 years earlier (13.8 years) than their immigrant counterparts. Conclusions Although Chinese-Americans in Texas had overall lower smoking rates than the general population, the high smoking rates among recently immigrated men emphasize the need for cessation activities targeting this group. C1 [Hu, Shaohua S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. [Pallonen, Unto E.; Meshack, Angela F.] Univ Texas Hlth Sci Ctr Houston, Ctr Hlth Promot & Prevent Res, Sch Publ Hlth, Houston, TX 77030 USA. RP Hu, SHS (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway NE,MS K-66, Atlanta, GA 30341 USA. EM shu@cdc.gov NR 42 TC 8 Z9 8 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD APR PY 2010 VL 12 IS 2 BP 206 EP 214 DI 10.1007/s10903-007-9097-z PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 645ZV UT WOS:000281505600007 PM 18030623 ER PT J AU Ullmann, A Dolan, M Fikrig, E Piesman, J Zeidner, N AF Ullmann, Amy Dolan, Marc Fikrig, Erol Piesman, Joseph Zeidner, Nordin TI Immunization with Adenoviral-expressed salivary gland proteins (SALPs) decreases spirochete load in a murine model of Lyme borreliosis SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Ullmann, Amy; Dolan, Marc; Piesman, Joseph; Zeidner, Nordin] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Fikrig, Erol] Yale Univ, Sch Med, Dept Internal Med, Sect Infect Dis, New Haven, CT 06510 USA. [Fikrig, Erol] Howard Hughes Med Inst, Chevy Chase, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2010 VL 184 SU 1 MA 52.2 PG 1 WC Immunology SC Immunology GA V44OM UT WOS:000209758301163 ER PT J AU Kourtis, AP AF Kourtis, Athena P. TI Antiretroviral Drug Use during Pregnancy and Risk of Premature Delivery: Is There a Connection? SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material ID HIV-INFECTED WOMEN; LOW-BIRTH-WEIGHT; PRETERM BIRTH; THERAPY; OUTCOMES; TRANSMISSION; INFANTS; COHORT; ERA C1 Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, 4770 Buford Hwy NE,MSK34, Atlanta, GA 30341 USA. EM apk3@cdc.gov NR 17 TC 4 Z9 4 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 1 PY 2010 VL 201 IS 7 BP 978 EP 980 DI 10.1086/651233 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 563KG UT WOS:000275129900003 PM 20196653 ER PT J AU France, AM Jackson, M Schrag, S Lynch, M Zimmerman, C Biggerstaff, M Hadler, J AF France, Anne Marie Jackson, Michael Schrag, Stephanie Lynch, Michael Zimmerman, Christopher Biggerstaff, Matthew Hadler, James TI Household Transmission of 2009 Influenza A (H1N1) Virus after a School-Based Outbreak in New York City, April-May 2009 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID OSELTAMIVIR-RESISTANT; INFECTION; TRIAL; RISK AB In April 2009, an outbreak due to infection with the 2009 pandemic influenza A (H1N1) virus (pH1N1) was investigated in a New York City high school. We surveyed household contacts of ill students to characterize the extent of transmission within households, identify contact groups at highest risk for illness, and assess the potential for preventing household transmission. Influenza-like illness (ILI) was reported by 79 of 702 household contacts (11.3% attack rate). Multivariate analysis showed that older age was protective: for each increasing year of age, the risk of ILI was reduced 5%. Additional protective factors included antiviral prophylaxis and having had a household discussion about influenza. Providing care for the index case patient and watching television with the index case patient were risk factors among parents and siblings, respectively. Fifty percent of cases occurred within 3 days of onset of illness in the student. These factors have implications for mitigating the impact of pH1N1 transmission. C1 [France, Anne Marie] New York City Dept Hlth & Mental Hyg, US Publ Hlth Serv, Bur Communicable Dis, New York, NY 10013 USA. [France, Anne Marie; Jackson, Michael] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Jackson, Michael; Schrag, Stephanie; Lynch, Michael; Biggerstaff, Matthew] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP France, AM (reprint author), New York City Dept Hlth & Mental Hyg, US Publ Hlth Serv, Bur Communicable Dis, 125 Worth St,Room 214A,CN 22A, New York, NY 10013 USA. EM afrance@health.nyc.gov FU New York City Department of Health and Mental Hygiene; Centers for Disease Control and Prevention FX New York City Department of Health and Mental Hygiene; Centers for Disease Control and Prevention. Presented in part: 137th Annual Meeting of the American Public Health Association, Philadelphia, 7-11 November 2009. NR 21 TC 74 Z9 77 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR 1 PY 2010 VL 201 IS 7 BP 984 EP 992 DI 10.1086/651145 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 563KG UT WOS:000275129900005 PM 20187740 ER PT J AU Whitaker, DJ Le, B Niolon, PH AF Whitaker, Daniel J. Le, Brenda Niolon, Phyllis Holditch TI Persistence and Desistance of the Perpetration of Physical Aggression Across Relationships Findings From a National Study of Adolescents SO JOURNAL OF INTERPERSONAL VIOLENCE LA English DT Article DE intimate partner violence; perpetration; persistence; desistance; trajectory ID INTIMATE PARTNER VIOLENCE; WIFE ASSAULT; COUPLES; STABILITY; MARRIAGE; YOUNG AB This study examined the persistent perpetration of physical intimate partner violence (IPV) across relationships. Based on the National Longitudinal Study on Adolescent Health, data were analyzed on 6,446 young adults, who reported on two recent relationships. Frequency and logistic regression analyses were used to examine the persistence of physical IPV perpetration across relationships and the predictors of persistent perpetration. Among individuals who perpetrated physical violence in their first relationship, 29.7% persisted in their perpetration in the second relationship and 70.3% desisted. Significant predictors of persistent physical IPV in the final multi-variate model were as follows: IPV frequency in the first relationship, age, living together versus apart in the subsequent relationship, respondent being better educated than the partner, and being an IPV victim in second relationship. The persistence of physical IPV across relationships was relatively low, with desistance being much more common. Factors specific to the second relationship were the strongest predictors of persistence. C1 [Whitaker, Daniel J.] Marcus Inst, Atlanta, GA 30329 USA. [Niolon, Phyllis Holditch] Ctr Dis Control & Prevent, Div Violence Prevent, Prevent Dev & Evaluat Branch, Atlanta, GA USA. RP Whitaker, DJ (reprint author), Marcus Inst, 1920 Briarcliff Rd, Atlanta, GA 30329 USA. EM Whitaker@Marcus.Org RI Whitaker, Daniel/C-1956-2009 NR 28 TC 18 Z9 19 U1 0 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0886-2605 J9 J INTERPERS VIOLENCE JI J. Interpers. Violence PD APR PY 2010 VL 25 IS 4 BP 591 EP 609 DI 10.1177/0886260509334402 PG 19 WC Criminology & Penology; Family Studies; Psychology, Applied SC Criminology & Penology; Family Studies; Psychology GA 562WO UT WOS:000275086400001 PM 19506166 ER PT J AU Chen, SC Veledar, E Soman, A Saraiya, M AF Chen, S. C. Veledar, E. Soman, A. Saraiya, M. TI How do sun protective habits (SPH) relate to vitamin D? A cross-sectional study using NHANES SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 05-08, 2010 CL Atlanta, GA SP Soc Investtigat Dermatol C1 [Chen, S. C.; Veledar, E.] Emory Univ, Atlanta, GA 30322 USA. [Chen, S. C.] VAMC, Atlanta, GA USA. [Soman, A.; Saraiya, M.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Veledar, Emir/K-2808-2012 OI Veledar, Emir/0000-0002-3831-5433 NR 0 TC 1 Z9 1 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2010 VL 130 SU 1 MA 368 BP S62 EP S62 PG 1 WC Dermatology SC Dermatology GA 580ND UT WOS:000276455100370 ER PT J AU Anderson, AM Fountain, JA Green, SB Bloom, SA Palmore, MP AF Anderson, Albert M. Fountain, Jack A. Green, Sonya B. Bloom, Sharon A. Palmore, Melody P. TI Human immunodeficiency virus-associated cytomegalovirus infection with multiple small vessel cerebral infarcts in the setting of early immune reconstitution SO JOURNAL OF NEUROVIROLOGY LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; VARICELLA-ZOSTER-VIRUS; ENDOTHELIAL-CELLS; INFLAMMATORY SYNDROME; ENCEPHALITIS; VASCULITIS; THERAPY; AUTOPSY; STROKE AB Cytomegalovirus (CMV) infection is an important cause of neurologic disease in the context of advanced human immunodeficiency virus (HIV) infection and is recognized as a cause of immune reconstitution inflammatory syndrome (IRIS) after initiation of highly active antiretroviral therapy (HAART). Central nervous system vasculitis secondary to CMV has only rarely been described in the context of HIV, despite the established ability of CMV to infect microvascular endothelial cells in the brain. However, we report a case that demonstrates the association between CMV and multiple small vessel cerebral infarct lesions after initiation of HAART.= 1 y using NHANES 2003-2006 data and the Dietary Reference Intake panel age groupings. Similar estimates were calculated for vitamin D intake from food and dietary supplements using NHANES 2005-2006. Diet was assessed with 2 24-h recalls; dietary supplement and antacid use were determined by questionnaire. The National Cancer Institute method was used to estimate usual nutrient intake from dietary sources. The mean daily nutrient intake from supplemental sources was added to the adjusted dietary intake estimates to produce total usual nutrient intakes for calcium and vitamin D. A total of 53% of the U.S. population reported using any dietary supplement (2003-2006), 43% used calcium (2003-2006), and 37% used vitamin D (2005-2006). For users, dietary supplements provided the adequate intake (AI) recommendation for calcium intake for similar to 12% of those 71 y. Males and females aged 1-3 y had the highest prevalence of meeting the AI from dietary and total calcium intakes. For total vitamin D intake, males and females >= 71, and females 14-18 y had the lowest prevalence of meeting the AI. Dietary supplement use is associated with higher prevalence of groups meeting the AI for calcium and vitamin D. Monitoring usual total nutrient intake is necessary to adequately characterize and evaluate the population's nutritional status and adherence to recommendations for nutrient intake. J. Nutr. 140: 817-822, 2010. C1 [Bailey, Regan L.; Dwyer, Johanna T.; Sempos, Christopher T.; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Dodd, Kevin W.] NCI, NIH, Bethesda, MD 20892 USA. [Goldman, Joseph A.; Moshfegh, Alanna J.] ARS, USDA, Beltsville, MD USA. [Gahche, Jaime J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Bailey, RL (reprint author), NIH, Off Dietary Supplements, Bldg 10, Bethesda, MD 20892 USA. EM baileyr@mail.nih.gov OI Dwyer, Johanna/0000-0002-0783-1769 NR 37 TC 214 Z9 214 U1 2 U2 25 PU AMER SOC NUTRITIONAL SCIENCE PI BETHESDA PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD APR PY 2010 VL 140 IS 4 BP 817 EP 822 DI 10.3945/jn.109.118539 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 571FI UT WOS:000275736700015 PM 20181782 ER PT J AU Suchdev, PS Leeds, IL McFarland, DA Flores, R AF Suchdev, Parminder S. Leeds, Ira L. McFarland, Deborah A. Flores, Rafael TI Is It Time to Change Guidelines for Iron Supplementation in Malarial Areas? SO JOURNAL OF NUTRITION LA English DT Letter ID DEFICIENCY; CHILDREN C1 [Suchdev, Parminder S.; Flores, Rafael] Ctr Dis Control & Prevent, Nutr Branch, Atlanta, GA 30341 USA. [Suchdev, Parminder S.; Leeds, Ira L.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Suchdev, Parminder S.; McFarland, Deborah A.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. RP Suchdev, PS (reprint author), Ctr Dis Control & Prevent, Nutr Branch, Atlanta, GA 30341 USA. EM psuchdev@cdc.gov RI Suchdev, Parmi/K-4851-2012; OI Suchdev, Parmi/0000-0002-0350-3469 NR 8 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC NUTRITIONAL SCIENCE PI BETHESDA PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD APR PY 2010 VL 140 IS 4 BP 875 EP 876 DI 10.3945/jn.109.118638 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 571FI UT WOS:000275736700025 PM 20147465 ER PT J AU Collins, WE Sullivan, JS Nace, D Williams, T Williams, A Barnwell, JW AF Collins, William E. Sullivan, JoAnn S. Nace, Douglas Williams, Tyrone Williams, Allison Barnwell, John W. TI OBSERVATIONS ON THE UGANDA I STRAIN OF PLASMODIUM MALARIAE AND PLASMODIUM BRASILIANUM IN AOTUS AND SAIMIRI MONKEYS AND ANOPHELES MOSQUITOES SO JOURNAL OF PARASITOLOGY LA English DT Article ID I/CDC STRAIN; EXPERIMENTAL-INFECTION; SCIUREUS-BOLIVIENSIS; SPOROZOITES; FREEBORNI; PARASITE AB Splenectomized Aotus lemurinus griseimembra, A. azarae boliviensis, A. nancymaae, A. vociferans, and Saimiri boliviensis monkeys were infected with the Uganda I/CDC strain of Plasmodium malariae. The maximum parasite counts were lower if the animals had been previously infected with Plasmodium vivax. Mosquito infection was concentrated in the 12 days following the rise in count above 1,000/mu l. Mosquito infection and parasite counts were highest with A. I. griseimembra. Anopheles freeborni was more readily infected than An. gambiae, which was more readily infected than An. stephensi. Parasite counts and mosquito infection with P. brasilianum were much higher in S. boliviensis monkeys than with the Uganda I strain of P. malariae in this host, suggesting marked differences between the host-parasite-vector relationships and indicating that P. brasilianum in S. boliviensis monkeys may be a better reflection of the relationship of P. malariae in the human host. C1 Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, US Publ Hlth Serv,Dept Hlth & Human Serv, Atlanta, GA 30341 USA. Ctr Dis Control & Prevent, Anim Resources Branch, Natl Ctr Preparedness Detect & Control Infect Dis, US Publ Hlth Serv,Dept Hlth & Human Serv, Atlanta, GA 30341 USA. RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Mail Stop F-36,4770 Buford Highway, Chamblee, GA 30341 USA. EM wec1@cdc.gov NR 24 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 J9 J PARASITOL JI J. Parasitol. PD APR PY 2010 VL 96 IS 2 BP 329 EP 339 DI 10.1645/GE-2283.1 PG 11 WC Parasitology SC Parasitology GA 610ZS UT WOS:000278780600011 PM 19891516 ER PT J AU Simoes, EJ Sumaya, CV AF Simoes, Eduardo J. Sumaya, Ciro V. TI Protecting and Enhancing Health: Community Engagement, Collaborations, and Incentives for Prevention SO JOURNAL OF PRIMARY PREVENTION LA English DT Editorial Material ID PUBLIC-HEALTH; CARE; DISADVANTAGE; DISEASE C1 [Simoes, Eduardo J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Sumaya, Ciro V.] Texas A&M Hlth Sci Ctr, Sch Rural Publ Hlth 1997 2008, College Stn, TX USA. RP Simoes, EJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Buford Hwy NE,MS K-45, Atlanta, GA 30341 USA. EM esimoes@cdc.gov OI Simoes, Eduardo/0000-0003-4371-4305 NR 43 TC 0 Z9 1 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0278-095X J9 J PRIM PREV JI J. Prim. Prev. PD APR PY 2010 VL 31 IS 1-2 SI SI BP 21 EP 29 DI 10.1007/s10935-010-0201-0 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 646AI UT WOS:000281506900003 PM 20112069 ER PT J AU Allen, KD Chen, JC Callahan, LF Golightly, YM Helmick, CG Renner, JB Jordan, JM AF Allen, Kelli D. Chen, Jiu-Chiuan Callahan, Leigh F. Golightly, Yvonne M. Helmick, Charles G. Renner, Jordan B. Jordan, Joanne M. TI Associations of Occupational Tasks with Knee and Hip Osteoarthritis: The Johnston County Osteoarthritis Project SO JOURNAL OF RHEUMATOLOGY LA English DT Article DE OSTEOARTHRITIS; OCCUPATIONS; HIP; KNEE ID REPORTED WORK HISTORY; RISK-FACTORS; PHYSICAL DEMANDS; NATIONAL-HEALTH; VALIDITY; WOMEN; QUESTIONNAIRE; PREVALENCE; LOAD; VALIDATION AB Objective. This cross-sectional study examined associations of occupational tasks with radiographic and symptomatic osteoarthritis (OA) in a community-based sample. Methods. Participants from the Johnston County Osteoarthritis Project (n = 2729) self-reported the frequency of performing 10 specific occupational tasks at the longest job ever held (never/seldom/sometimes vs often/always) and lifetime exposure to jobs that required spending > 50% of their time doing 5 specific tasks or lifting 22, 44, or 110 pounds 10 times weekly. Multivariable logistic regression models examined associations of each occupational task separately with radiographic and symptomatic knee and hip OA, controlling for age, race, gender, body mass index, prior knee or hip injury, and smoking. Results. Radiographic hip and knee OA were not significantly associated with any occupational tasks, but several occupational tasks were associated with increased odds of both symptomatic knee and hip OA: lifting > 10 pounds, crawling, and doing heavy work while standing (OR 1.4-2.1). More occupational walking and standing and less sitting were also associated with symptomatic knee OA, and more bending/twisting/reaching was associated with symptomatic hip OA. Exposure to a greater number of physically demanding occupational tasks at the longest job was associated with greater odds of both symptomatic knee and hip OA. Conclusion. Our results confirm an association of physically demanding occupational tasks with both symptomatic knee and hip OA, including several specific activities that increased the odds of OA in both joint groups. These tasks represent possibilities for identifying and targeting at-risk individuals with preventive interventions. (First Release Feb 15 2010; J Rheumatol 2010;37:842-50; doi: 10.3899/jrheum.090302) C1 [Allen, Kelli D.; Golightly, Yvonne M.] Durham Vet Affairs Med Ctr, Hlth Serv Res & Dev Serv, Durham, NC USA. [Allen, Kelli D.] Duke Univ, Dept Med, Med Ctr, Div Gen Internal Med, Durham, NC 27706 USA. [Callahan, Leigh F.; Renner, Jordan B.; Jordan, Joanne M.] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA. [Callahan, Leigh F.; Jordan, Joanne M.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Callahan, Leigh F.; Jordan, Joanne M.] Univ N Carolina, Dept Orthopaed, Chapel Hill, NC USA. [Callahan, Leigh F.] Univ N Carolina, Dept Social Med, Chapel Hill, NC USA. [Golightly, Yvonne M.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Renner, Jordan B.] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA. [Chen, Jiu-Chiuan] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Helmick, Charles G.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Allen, KD (reprint author), VA Med Ctr, HSR&D 152,508 Fulton St, Durham, NC 27705 USA. EM kelli.allen@duke.edu RI Chen, JC/I-2261-2016 FU Centers for Disease Control and Prevention/Association of Schools of Public Health [S043, S1734, S3486]; MARS Multipurpose Arthritis and Musculoskeletal Disease Center [5-P60-AR30701]; MAXIS Multidisciplinary Clinical Research Center [5 P60 AR49465-03]; NIAMS [T-32-AR007416] FX Supported in part by cooperative agreements S043, S1734, and S3486 from the Centers for Disease Control and Prevention/Association of Schools of Public Health; the MARS Multipurpose Arthritis and Musculoskeletal Disease Center grant 5-P60-AR30701; and the MAXIS Multidisciplinary Clinical Research Center grant 5 P60 AR49465-03 and NIAMS Arthritis and Immunology Training Grant T-32-AR007416. NR 43 TC 28 Z9 28 U1 3 U2 9 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD APR PY 2010 VL 37 IS 4 BP 842 EP 850 DI 10.3899/jrheum.090302 PG 9 WC Rheumatology SC Rheumatology GA 584WI UT WOS:000276783900025 PM 20156951 ER PT J AU Shults, RA AF Shults, Ruth A. TI Foreword to "Graduated Driver Licensing Research, 2007-Present: A Review and Commentary" SO JOURNAL OF SAFETY RESEARCH LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Shults, RA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM rshults@cdc.gov NR 3 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD APR PY 2010 VL 41 IS 2 BP 75 EP 75 DI 10.1016/j.jsr.2010.04.001 PG 1 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 614MA UT WOS:000279061900001 PM 20497791 ER PT J AU Williams, AF Shults, RA AF Williams, Allan F. Shults, Ruth A. TI Graduated Driver Licensing Research, 2007-Present: A Review and Commentary SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE Graduated driver licensing; Teenage drivers; Beginning drivers ID TEENAGE DRIVERS; PARENT INVOLVEMENT; INJURY RISK; CRASHES; ATTITUDES; EDUCATION; AGE; PROGRAM; TECHNOLOGY; EXPERIENCE AB The evolution of graduated licensing systems in the past 25 years has resulted in dramatic growth in research on this topic. The most recent summary reports have covered the period up to 2007. In the present article more recent and ongoing research is categorized, summarized, and discussed. Published by Elsevier Ltd. C1 [Williams, Allan F.] Allan F Williams LLC, Bethesda, MD USA. [Shults, Ruth A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Williams, AF (reprint author), Allan F Williams LLC, Bethesda, MD USA. EM Allan.F.Williams@gmail.com NR 67 TC 45 Z9 46 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD APR PY 2010 VL 41 IS 2 BP 77 EP 84 DI 10.1016/j.jsr.2010.03.002 PG 8 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 614MA UT WOS:000279061900002 PM 20497792 ER PT J AU Greenspan, AI Dellinger, AM Chen, JR AF Greenspan, Arlene I. Dellinger, Ann M. Chen, Jieru TI Restraint use and seating position among children less than 13 years of age: Is it still a problem? SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE seat belt; seating position; premature use of seat belts; children ID UNITED-STATES; BOOSTER SEATS; CRASHES; TRENDS AB Introduction: The purpose of this study was to calculate national estimates and examine the extent to which children prematurely use adult seat belts and ride in the front seat of a vehicle during a 30 day period. Methods: Data were obtained from a nationally representative cross-sectional random-digit-dial telephone survey that included child-specific questions on motor vehicle restraint use and seating position. Results: Among children less than 13 years, parents reported an estimated 618,337 who rode unrestrained and more than one million who rode in the front seat of a vehicle at least some of the time in the past 30 days. During the same time period, close to 11 million children 8 years and younger reportedly used only adult seat belts. Discussion: Our results highlight the need for continued outreach to parents regarding optimal restraint use and rear seating position for children every trip, every time. (C) 2010 Published by Elsevier Ltd. C1 [Greenspan, Arlene I.; Dellinger, Ann M.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Atlanta, GA 30341 USA. [Chen, Jieru] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30341 USA. RP Greenspan, AI (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA. EM agreenspan@cdc.gov; adellinger@cdc.gov; chen@cdc.gov NR 17 TC 14 Z9 15 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD APR PY 2010 VL 41 IS 2 BP 183 EP 185 DI 10.1016/j.jsr.2010.03.001 PG 3 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 614MA UT WOS:000279061900014 PM 20497804 ER PT J AU Kohn, W AF Kohn, William TI TB ALERT Response SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Letter C1 [Kohn, William] Ctr Dis Control & Prevent, Div Oral Hlth, Atlanta, GA 30333 USA. RP Kohn, W (reprint author), Ctr Dis Control & Prevent, Div Oral Hlth, Atlanta, GA 30333 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD APR PY 2010 VL 141 IS 4 BP 381 EP 382 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 580TR UT WOS:000276473800004 ER PT J AU Zhang, XZ Decker, FH Luo, HB Geiss, LS Pearson, WS Saaddine, JB Gregg, EW Albright, A AF Zhang, Xinzhi Decker, Frederic H. Luo, Huabin Geiss, Linda S. Pearson, William S. Saaddine, Jinan B. Gregg, Edward W. Albright, Ann TI Trends in the Prevalence and Comorbidities of Diabetes Mellitus in Nursing Home Residents in the United States: 1995-2004 SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE diabetes mellitus; nursing home; elderly; comorbidities ID COGNITIVE DECLINE; US; BURDEN; COMPLICATIONS; POPULATION; ELDERS; NEEDS; OLDER; CARE AB OBJECTIVES To estimate trends in the prevalence and comorbidities of diabetes mellitus (DM) in U.S. nursing homes from 1995 to 2004. DESIGN SAS callable SUDAAN was used to adjust for the complex sample design and assess changes in prevalence of DM and comorbidities during the study period in the National Nursing Home Surveys. Trends were assessed using weighted least squares linear regression. Multiple logistic regressions were used to calculate predictive margins. SETTING A continuing series of two-stage, cross-sectional probability national sampling surveys. PARTICIPANTS Residents aged 55 and older: 1995 (n=7,722), 1997 (n=7,717), 1999 (n=7,809), and 2004 (n=12,786). MEASUREMENTS DM and its comorbidities identified using a standard set of diagnosis codes. RESULTS The estimated crude prevalence of DM increased from 16.9% in 1995 to 26.4% in 2004 in male nursing home residents and from 16.1% to 22.2% in female residents (all P <.05). Male and female residents aged 85 and older and those with high functional impairment showed a significant increasing trend in DM (all P <.05). In people with DM, multivariate-adjusted prevalence of cardiovascular disease increased from 59.6% to 75.4% for men and from 68.1% to 78.7% for women (all P <.05). Prevalence of most other comorbidities did not increase significantly. CONCLUSION The burden of DM in residents of U.S. nursing homes has increased since 1995. This could be due to increasing DM prevalence in the general population or to changes in the population that nursing homes serve. Nursing home care practices may need to change to meet residents' changing needs. C1 [Zhang, Xinzhi; Geiss, Linda S.; Saaddine, Jinan B.; Gregg, Edward W.; Albright, Ann] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Pearson, William S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Decker, Frederic H.] Ctr Dis Control & Prevent, Long Term Care Stat Branch, Div Hlth Care Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Luo, Huabin] Mt Olive Coll, Mt Olive, NC USA. RP Zhang, XZ (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE K-10, Atlanta, GA 30341 USA. EM XZhang4@cdc.gov NR 30 TC 42 Z9 42 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2010 VL 58 IS 4 BP 724 EP 730 DI 10.1111/j.1532-5415.2010.02786.x PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 577TN UT WOS:000276247000015 PM 20398154 ER PT J AU Grefsheim, SF Whitmore, SC Rapp, BA Rankin, JA Robison, RR Canto, CC AF Grefsheim, Suzanne F. Whitmore, Susan C. Rapp, Barbara A. Rankin, Jocelyn A. Robison, Rex R. Canto, Candace C. TI The informationist: building evidence for an emerging health profession SO JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION LA English DT Article ID CLINICAL QUESTIONS; BIOMEDICAL-RESEARCH; CARE; PROGRAM; SERVICE; NEEDS; IMPLEMENTATION; ANSWERS AB Background: To encourage evidence-based practice, an Annals of Internal Medicine editorial called for a new professional on clinical teams: an informationist trained in science or medicine as well as information science. Objectives: The study explored the effects of informationists on information behaviors of clinical research teams, specifically, frequency of seeking information for clinical or research decisions, range of resources consulted, perceptions about access to information, confidence in adequacy of literature searches, and effects on decision making and practice. It also explored perceptions about training and experience needed for successful informationists. Methods: Exploratory focus groups and key interviews were followed by baseline and follow-up surveys conducted with researchers and clinicians receiving the service. Survey data were analyzed with Pearson's chi-square or Fisher's exact test. Results: Comparing 2006 to 2004 survey responses, the researchers found that study participants reported: seeking answers to questions more frequently, spending more time seeking or using information, believing time was less of an obstacle to finding or using information, using more information resources, and feeling greater satisfaction with their ability to find answers. Participants' opinions on informationists' qualifications evolved to include both subject knowledge and information searching expertise. Conclusion: Over time, clinical research teams with informationists demonstrated changes in their information behaviors, and they valued an informationist's subject matter expertise more. C1 [Grefsheim, Suzanne F.; Whitmore, Susan C.] NIH Lib, Informat & Educ Serv Branch, Div Lib Serv, NIH, Bethesda, MD 20892 USA. [Rapp, Barbara A.] Natl Lib Med, Off Hlth Informat Programs Dev, Nihon Univ, Bethesda, MD 20894 USA. [Rankin, Jocelyn A.] Ctr Dis Control & Prevent, CDC Informat Ctr, Atlanta, GA 30333 USA. RP Grefsheim, SF (reprint author), NIH Lib, Informat & Educ Serv Branch, Div Lib Serv, NIH, 10 Ctr Dr,MSC 1150, Bethesda, MD 20892 USA. EM grefshes@nih.gov; whitmors@mail.nih.gov; rappb@nlm.nih.gov; jrankin@cdc.gov; robisonr@mail.nih.gov; cantoc@gmail.com RI Robison, Rex/B-4174-2008 OI Robison, Rex/0000-0002-6885-5051 NR 26 TC 8 Z9 9 U1 3 U2 18 PU MEDICAL LIBRARY ASSOC PI CHICAGO PA 65 EAST WACKER PLACE, STE 1900, CHICAGO, IL 60601-7298 USA SN 1536-5050 J9 J MED LIBR ASSOC JI J. Med. Libr. Assoc. PD APR PY 2010 VL 98 IS 2 BP 147 EP 156 DI 10.3163/1536-5050.98.2.007 PG 10 WC Information Science & Library Science SC Information Science & Library Science GA 593IN UT WOS:000277447300007 PM 20428280 ER PT J AU Friggens, MM Parmenter, RR Boyden, M Ford, PL Gage, K Keim, P AF Friggens, Megan M. Parmenter, Robert R. Boyden, Michael Ford, Paulette L. Gage, Kenneth Keim, Paul TI FLEA ABUNDANCE, DIVERSITY, AND PLAGUE IN GUNNISON'S PRAIRIE DOGS (CYNOMYS GUNNISONI) AND THEIR BURROWS IN MONTANE GRASSLANDS IN NORTHERN NEW MEXICO SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Insect vectors; Oropsylla tuberculata cynomuris; reservoir hosts; small mammals ID EARLY-PHASE TRANSMISSION; YERSINIA-PESTIS; CERATOPHYLLIDAE; SIPHONAPTERA; EPIZOOTICS; MAMMALS; VECTOR; LUDOVICIANUS; PERSISTENCE; PREVALENCE AB Plague, a flea-transmitted infectious disease caused by the bacterium Yersinia pestis, is a primary threat to the persistence of prairie dog populations (Cynomys spp.). We conducted a 3-yr survey (2004-2006) of fleas from Gunnison's prairie dogs (Cynomys gunnisoni) and their burrows in montane grasslands in Valles Caldera National Preserve in New Mexico. Our objectives were to describe flea communities and identify flea and rodent species important to the maintenance of plague. We live-trapped prairie dogs and conducted burrow sweeps at three colonies in spring and summer of each year. One hundred thirty prairie dogs and 51 golden-mantled ground squirrels (Spermophilus let-myths) were captured over 3,640 trap nights and 320 burrows were swabbed for fleas. Five flea species were identified from prairie clogs and ground squirrels and four were identified from burrow samples. Oropsylla hirsute was the most abundant species found on prairie clogs and in burrows. Oropsylla idahoensis was most common on ground squirrels. Two colonies experienced plague epizootics in fall 2004. Plague-positive fleas were recovered from burrows (O. hirsuta and Oropsylla tuberculate tuberculate) and a prairie clog (O. hirsuta) in spring 2005 and summer 2006. Three prairie dogs collected in summer 2005 and 2006 had plague antibody. We found a significant surge in flea abundance and prevalence, particularly within burrows, following plague exposure. We noted an increased tendency for flea exchange opportunities in the spring before O. hirsute reached its peak population. We hypothesize that the role of burrows as a site of flea exchange, particularly between prairie clogs and ground squirrels, may be as important as summer conditions that lead to buildup in O. hirsute populations for determining plague outbreaks. C1 [Friggens, Megan M.] No Arizona Univ, Sch Forestry, Flagstaff, AZ 86011 USA. [Parmenter, Robert R.] Valles Caldera Natl Preserve, Jemez Springs, NM 87025 USA. [Boyden, Michael] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA. [Ford, Paulette L.] US Forest Serv, USDA, Rocky Mt Res Stn, Albuquerque, NM 87102 USA. [Gage, Kenneth] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Infect Dis, Natl Ctr Infect Dis, Ft Collins, CO 80521 USA. [Keim, Paul] No Arizona Univ, Dept Biol, Flagstaff, AZ 86011 USA. RP Friggens, MM (reprint author), No Arizona Univ, Sch Forestry, 200 Pine Knoll Dr, Flagstaff, AZ 86011 USA. EM meganfriggens@fs.fed.us RI Keim, Paul/A-2269-2010 FU Ecology of Infectious Diseases program at NSF/NIH [EF-0326757]; Sevilleta LIFER Graduate Student Fellowships [NSF DEB-0217774, DEB-0620482]; USDA Forest Service Rocky Mountain Research Station FX John Montieneri provided training for the identification of fleas. Kelly Shelf, Ying Bai, and Christina Moray provided laboratory assistance or training. Laboratory space and equipment were provided by Paul Keim's genetics laboratory at Northern Arizona University (Chris Allender, Dave Wagner); the laboratories of Donald Duszynski, Samuel Loker, and Joseph Cook at the University of New Mexico (UNM); the UNM Museum of Southwestern Biolog, Arthropod Division (Sandra Brantley, David Lightfoot) and the Division of Genomic Resources (Cheryl Parmenter); the UNM molecular facility (George Rosenburg, Jennifer Hath-away); and the Sevilleta Long Term Ecological Research (LTER) Program. We thank the Valles Caldera National Preserve for the use of their land. We thank the technicians who assisted with burrow sweeps and prairie dog captures: Ana Oyer, Mary Brandenburg, Levi Parks, Alexei Wajchman, Sara Noel Ross, and Leif Emkeit. Mike T. Friggens created Figure T. This research was funded by the Ecology of Infectious Diseases program at NSF/NIH (EF-0326757), the Sevilleta LIFER Graduate Student Fellowships (NSF DEB-0217774, DEB-0620482), and the USDA Forest Service Rocky Mountain Research Station. NR 40 TC 5 Z9 6 U1 2 U2 21 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD APR PY 2010 VL 46 IS 2 BP 356 EP 367 PG 12 WC Veterinary Sciences SC Veterinary Sciences GA 593DA UT WOS:000277431200003 PM 20688629 ER PT J AU Roland, KB Larkins, TL Benard, VB Berkowitz, Z Saraiya, M AF Roland, Katherine B. Larkins, Teri L. Benard, Vicki B. Berkowitz, Zahava Saraiya, Mona TI Content Analysis of Continuing Medical Education for Cervical Cancer Screening SO JOURNAL OF WOMENS HEALTH LA English DT Article ID HUMAN-PAPILLOMAVIRUS; COST-EFFECTIVENESS; UNITED-STATES; MANAGEMENT; SOCIETY; WOMEN; INFORMATION; GUIDELINES; CYTOLOGY; INDUSTRY AB Background: Since 2003, newer cervical cancer screening guidelines that include human papillomavirus (HPV) testing with cytology (HPV co-testing) call for extension of screening intervals in women who are cytology normal and HPV negative. Continuing medical education (CME) may help increase knowledge and appropriate adoption of new technologies and guidelines. However, there are concerns that industry support of CME may bias messages favoring newer technologies without emphasizing the updated guidelines, especially less frequent testing recommendations. Our objectives were to assess availability and accuracy of web-based CME activities describing cervical cancer screening guidelines, screening intervals, and HPV testing. Methods: We identified 20 web-based CME activities available between 2006 and 2008 and evaluated the content for messages related to HPV and natural history, cervical cancer screening guidelines, management of HPV abnormalities, and counseling tips for patients. In addition to content, we noted funding source, credit offered, and dates available. Results: Most activities (80%) discussed the updated screening guidelines with HPV co-testing for eligible women. Twelve activities (60%) referenced professional organization support of the extended screening interval with the HPV co-test, and three (15%) discussed the justification for extension of intervals for eligible women. Eight activities (40%) were funded by industry, seven of which included accurate, updated screening guidelines about extension of screening intervals. Conclusions: Web-based CME activities generally support updated guidance for HPV co-testing and extended screening intervals but need more information on counseling patients and acceptability of extending screening intervals. C1 [Roland, Katherine B.; Larkins, Teri L.; Benard, Vicki B.; Berkowitz, Zahava; Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. RP Roland, KB (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway NE,MS K-55, Atlanta, GA 30341 USA. EM kroland@cdc.gov NR 29 TC 1 Z9 1 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD APR PY 2010 VL 19 IS 4 BP 651 EP 657 DI 10.1089/jwh.2009.1928 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 587XS UT WOS:000277030400001 PM 20350199 ER PT J AU Prue, CE Hamner, HC Flores, AL AF Prue, Christine E. Hamner, Heather C. Flores, Alina L. TI Effects of Folic Acid Awareness on Knowledge and Consumption for the Prevention of Birth Defects Among Hispanic Women in Several US Communities SO JOURNAL OF WOMENS HEALTH LA English DT Article ID NEURAL-TUBE DEFECTS; UNITED-STATES; SPINA-BIFIDA; METHYLENETETRAHYDROFOLATE REDUCTASE; VITAMIN; RACE/ETHNICITY; PREVALENCE; RISK AB Background: The neural tube defects (NTDs) anencephaly and spina bifida, are serious birth defects of the brain and spine that affect about 3000 pregnancies per year in the United States. Research has found a strong link between periconceptional folic acid consumption and NTD prevention. Methods: Because Hispanic women have higher rates of NTD-affected births, targeted folic acid promotion efforts were conducted in several major cities from 1999 to 2002. Efforts included paid and unpaid placements of Spanish language public service announcements (PSAs) and community-level education through the use of promotoras. Analyses focused on whether or not women's reported awareness of folic acid, regardless of promotion type, impacted their knowledge or behavior. Results and Conclusions: Women who reported awareness of folic acid had greater folic acid knowledge and use of vitamins containing folic acid than those not aware. Analyses also examined the use of vitamins containing folic acid by pregnancy intention among women who reported awareness of folic acid. The results were varied. Pregnancy wanters were most likely to use vitamins containing folic acid daily. For this group, however, awareness did not play as large a role in whether they reported consuming a vitamin containing folic acid or not, as it did for pregnancy waiters and avoiders. C1 [Hamner, Heather C.; Flores, Alina L.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Prue, Christine E.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Flores, AL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Mailstop E-86, Atlanta, GA 30333 USA. EM ail5@cdc.gov FU Westat; National Alliance for Hispanic Health; Congreso de Latinos Unidos; Latin American Research and Service Agency (LARASA) FX We would like to acknowledge Westat, the National Alliance for Hispanic Health, Congreso de Latinos Unidos, and Latin American Research and Service Agency (LARASA) for their contributions in support of this research. NR 34 TC 4 Z9 5 U1 1 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD APR PY 2010 VL 19 IS 4 BP 689 EP 698 DI 10.1089/jwh.2009.1573 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 587XS UT WOS:000277030400006 PM 20201699 ER PT J AU Bennett, SN Drummond, AJ Kapan, DD Suchard, MA Munoz-Jordan, JL Pybus, OG Holmes, EC Gubler, DJ AF Bennett, S. N. Drummond, A. J. Kapan, D. D. Suchard, M. A. Munoz-Jordan, J. L. Pybus, O. G. Holmes, E. C. Gubler, D. J. TI Epidemic Dynamics Revealed in Dengue Evolution SO MOLECULAR BIOLOGY AND EVOLUTION LA English DT Article DE adaptive evolution; phylodynamics; dengue; virus; epidemics; population bottlenecks ID PUERTO-RICO; HEMORRHAGIC-FEVER; VIRUS; THAILAND; BANGKOK; MODEL; PATTERN AB Dengue is an emerging tropical disease infecting tens of millions of people annually. A febrile illness with potentially severe hemorrhagic manifestations, dengue is caused by mosquito-borne viruses (DENV-1 to -4) that are maintained in endemic transmission in large urban centers of the tropics with periodic epidemic cycles at 3- to 5-year intervals. Puerto Rico ( PR), a major population center in the Caribbean, has experienced increasingly severe epidemics since multiple dengue serotypes were introduced beginning in the late 1970s. We document the phylodynamics of DENV-4 between 1981 and 1998, a period of dramatic ecological expansion during which evolutionary change also occurs. The timescale of viral evolution is sufficiently short that viral transmission dynamics can be elucidated from genetic diversity data. Specifically, by combining virus sequence data with confirmed case counts in PR over these two decades, we show that the pattern of cyclic epidemics is strongly correlated with coalescent estimates of effective population size that have been estimated from sampled virus sequences using Bayesian Markov Chain Monte Carlo methods. Thus, we show that the observed epidemiologic dynamics are correlated with similar fluctuations in diversity, including severe interepidemic reductions in genetic diversity compatible with population bottlenecks that may greatly impact DENV evolutionary dynamics. Mean effective population sizes based on genetic data appear to increase prior to isolation counts, suggesting a potential bias in the latter and justifying more active surveillance of DENV activity. Our analysis explicitly integrates epidemiologic and sequence data in a joint model that could be used to further explore transmission models of infectious disease. C1 [Bennett, S. N.; Gubler, D. J.] Univ Hawaii Manoa, Dept Trop Med Med Microbiol & Pharmacol, Asia Pacific Inst Trop Med & Infect Dis, JA Burns Sch Med, Honolulu, HI 96822 USA. [Drummond, A. J.] Univ Auckland, Dept Comp Sci, Auckland 1, New Zealand. [Kapan, D. D.] Univ Hawaii Manoa, Ctr Conservat & Res Training, Honolulu, HI 96822 USA. [Suchard, M. A.] Univ Calif Los Angeles, Dept Biomath Biostat & Human Genet, David Geffen Sch Med, Los Angeles, CA 90024 USA. [Munoz-Jordan, J. L.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, San Juan, PR USA. [Pybus, O. G.] Univ Oxford, Dept Zool, Oxford OX1 3PS, England. [Holmes, E. C.] Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA. [Gubler, D. J.] Duke NUS Grad Med Sch, Singapore, Singapore. RP Bennett, SN (reprint author), Univ Hawaii Manoa, Dept Trop Med Med Microbiol & Pharmacol, Asia Pacific Inst Trop Med & Infect Dis, JA Burns Sch Med, Honolulu, HI 96822 USA. EM sbennett@hawaii.edu RI pybus, oliver/B-2640-2012; Drummond, Alexei/A-3209-2010; OI Drummond, Alexei/0000-0003-4454-2576; Pybus, Oliver/0000-0002-8797-2667; Holmes, Edward/0000-0001-9596-3552 FU NIH [NIH-RR018727, NIH-AI065359, NIH-RR003061, DOD-06187000, NSF-OIA0554657] FX Thanks goes to Vance Vorndam, Manuela Beltran, and Maritza Chirivella for their involvement since the beginning with the dengue virus type 4 isolations and sequencing from the CDC collection. Research was supported by NIH-RR018727, NIH-AI065359, NIH-RR003061, DOD-06187000, and NSF-OIA0554657. NR 31 TC 52 Z9 53 U1 1 U2 22 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0737-4038 J9 MOL BIOL EVOL JI Mol. Biol. Evol. PD APR PY 2010 VL 27 IS 4 BP 811 EP 818 DI 10.1093/molbev/msp285 PG 8 WC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity GA 582ZJ UT WOS:000276639800008 PM 19965886 ER PT J AU Veluthoor, S Li, SJ Kelsey, RG Dolan, MC Panella, NA Karchesy, J AF Veluthoor, Sheeba Li, Shujun Kelsey, Rick G. Dolan, Marc C. Panella, Nicholas A. Karchesy, Joe TI Two New Diterpene Phenols from Calocedrus decurrans SO NATURAL PRODUCT COMMUNICATIONS LA English DT Article DE Calocedrus decurrans; Cupressaceae; diterpenes; p-cymene derivatives ID EXTRACTIVE COMPONENTS; PARA-METHOXYTHYMOL; TORREY AB Two new p-cymene based diphenols (1-2) were isolated from the heartwood of Calocedrus decurrans. Structures were elucidated by ID and 2D NMR techniques and HRMS. Libocedroquinone (3) was also isolated as a natural product for the first time. A new system of nomenclature is proposed for description of such oligomeric p-cymene derivatives. C1 [Veluthoor, Sheeba; Karchesy, Joe] Oregon State Univ, Corvallis, OR 97331 USA. [Li, Shujun] NE Forestry Univ, Minist Educ, Key Lab Biobased Mat Sci & Technol, Harbin, Peoples R China. [Kelsey, Rick G.] US Forest Serv, USDA, PNW Res Stn, Corvallis, OR 97331 USA. [Dolan, Marc C.; Panella, Nicholas A.] Ctr Dis Control & Prevent, Ft Collins, CO 80522 USA. RP Veluthoor, S (reprint author), Oregon State Univ, 119 Richardson Hall, Corvallis, OR 97331 USA. EM sheeba.veluthoor@gmail.com NR 10 TC 2 Z9 2 U1 1 U2 1 PU NATURAL PRODUCTS INC PI WESTERVILLE PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA SN 1934-578X J9 NAT PROD COMMUN JI Nat. Prod. Commun. PD APR PY 2010 VL 5 IS 4 BP 519 EP 522 PG 4 WC Chemistry, Medicinal; Food Science & Technology SC Pharmacology & Pharmacy; Food Science & Technology GA 582LJ UT WOS:000276598500004 PM 20433063 ER PT J AU Khoury, MJ Evans, J Burke, W AF Khoury, Muin J. Evans, James Burke, Wylie TI Personal Genomics and Personalized Medicine SO NATURE LA English DT Book Review C1 [Khoury, Muin J.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Evans, James] Univ N Carolina, Clin Canc Genet Serv, Chapel Hill, NC 27599 USA. [Burke, Wylie] Univ Washington, Dept Bioeth & Humanities, Seattle, WA 98195 USA. RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30333 USA. EM muk1@cdc.gov NR 1 TC 7 Z9 7 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD APR 1 PY 2010 VL 464 IS 7289 BP 680 EP 680 DI 10.1038/464680a PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 577EO UT WOS:000276205000022 ER PT J CA Calif Pandemic H1N1 Working Grp TI Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California EDITORIAL COMMENT SO OBSTETRICAL & GYNECOLOGICAL SURVEY LA English DT Editorial Material C1 Calif Dept Publ Hlth, Richmond, CA 30333 USA. Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7828 J9 OBSTET GYNECOL SURV JI Obstet. Gynecol. Surv. PD APR PY 2010 VL 65 IS 4 BP 227 EP 228 DI 10.1097/01.ogx.0000371713.49382.2f PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 591YQ UT WOS:000277341900010 ER PT J AU Creanga, AA Johnson, TF Graitcer, SB Hartman, LK Al-Samarrai, T Schwarz, AG Chu, SY Sackoff, JE Jamieson, DJ Fine, AD Shapiro-Mendoza, CK Jones, LE Uyeki, TM Balter, S Bish, CL Finelli, L Honein, MA AF Creanga, Andreea A. Johnson, Tamisha F. Graitcer, Samuel B. Hartman, Laura K. Al-Samarrai, Teeb Schwarz, Aviva G. Chu, Susan Y. Sackoff, Judith E. Jamieson, Denise J. Fine, Anne D. Shapiro-Mendoza, Carrie K. Jones, Lucretia E. Uyeki, Timothy M. Balter, Sharon Bish, Connie L. Finelli, Lyn Honein, Margaret A. TI Severity of 2009 Pandemic Influenza A (H1N1) Virus Infection in Pregnant Women SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID IMMUNIZATION PRACTICES ACIP; CRITICALLY-ILL PATIENTS; EMERGING INFECTIONS; ADVISORY-COMMITTEE; A(H1N1); RECOMMENDATIONS; PREVENTION; HUMANS; IMPACT AB OBJECTIVE: To examine 2009 H1N1 influenza illness severity and the effect of antiviral treatment on the severity of illness among pregnant women. METHODS: We abstracted medical records from hospitalized pregnant (n = 62) and nonpregnant (n = 74) women with laboratory-confirmed 2009 H1N1 influenza in New York City, May through June 2009. We compared characteristics of pregnant and nonpregnant women and of severe and moderate influenza illness among pregnant women, with severe defined as illness resulting in intensive care admission or death. RESULTS: The 2009 H1N1 hospitalization rate was significantly higher among pregnant than nonpregnant women (55.3 compared with 7.7 per 100,000 population). Eight pregnant (including two deaths) and 16 nonpregnant (including four deaths) cases were severe. Pregnant women represented 6.4% of hospitalized cases and 4.3% of deaths caused by 2009 H1N1 influenza. Only 1 in 30 (3.3%) pregnant women who received oseltamivir treatment within 2 days of symptom onset had severe illness compared with 3 of 14 (21.4%) and four of nine (44.4%) pregnant women who started treatment 3-4 days and 5 days or more after symptom onset, respectively (P = .002 for trend). Severe and moderate 2009 H1N1 influenza illness occurred in all pregnancy trimesters, but most women (54.8%) were in the third trimester. Twenty-two women delivered during their influenza hospitalization, and severe neonatal outcomes (neonatal intensive care unit admission or death) occurred among five of six (83.3%) women with severe illness compared with 2 of 16 (12.5%) women with moderate illness (P = .004). CONCLUSION: Our findings highlight the potential for severe illness and adverse neonatal outcomes among pregnant 2009 H1N1 influenza-infected women and suggest the benefit of early oseltamivir treatment. (Obstet Gynecol 2010; 115: 717-26) C1 [Creanga, Andreea A.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. New York City Dept Hlth & Mental Hyg, New York, NY USA. Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Creanga, AA (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, 4770 Buford Highway NE,Mail Stop K-23, Atlanta, GA 30341 USA. EM acreanga@cdc.gov NR 24 TC 143 Z9 152 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2010 VL 115 IS 4 BP 717 EP 726 DI 10.1097/AOG.0b013e3181d57947 PG 10 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 580QH UT WOS:000276463700007 PM 20308830 ER PT J AU Barry, PM Kent, CK Philip, SS Klausner, JD AF Barry, Pennan M. Kent, Charlotte K. Philip, Susan S. Klausner, Jeffrey D. TI Results of a Program to Test Women for Rectal Chlamydia and Gonorrhea SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID HETEROSEXUAL ANAL INTERCOURSE; NEISSERIA-GONORRHOEAE; COST-EFFECTIVENESS; GENITAL-INFECTION; RISK-FACTORS; TRACHOMATIS; PREVALENCE; SEX; MEN; POPULATION AB OBJECTIVE: To analyze whether rectal testing among women increased chlamydia and gonorrhea case-finding and whether reported receptive anal intercourse was a risk factor for rectal infection. METHODS: From March 2007 to August 2008, women receiving pelvic examinations at the San Francisco sexually transmitted disease clinic were tested for rectal gonorrhea and chlamydia by using a transcription-mediated amplification assay. Results of testing and clinical and demographic data were analyzed using a cross-sectional study design. RESULTS: Of 1,308 women with both rectal and vaginal tests, test results were positive for 79 patients (6.0%) for rectal chlamydia or gonorrhea and 88 patients (6.7%) for genital chlamydia or gonorrhea. Test results were positive for 13 patients (1.0%) at the rectum only, increasing detection from 88 to 101 patients (14.8%; 95% confidence interval 8.1-23.9). No correlation existed between reported anal sex and rectal chlamydia (P=.74); however, 50% of women with rectal gonorrhea reported anal sex compared with 21% of women without rectal gonorrhea (P=.002). CONCLUSION: Sexually transmitted disease clinics might improve chlamydia and gonorrhea case-finding through rectal testing of women, but more study is needed to determine the effects of finding and treating such infections. Reporting anal intercourse did not predict rectal chlamydial infection among women tested at both the rectum and the vagina. (Obstet Gynecol 2010;115:753-9) C1 Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. San Francisco Dept Publ Hlth, San Francisco, CA USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Barry, PM (reprint author), 1360 Mission St,Suite 401, San Francisco, CA 94103 USA. EM pennanbarry@gmail.com FU U.S. Public Health Service T32 [AI007641-06A2]; Forest Laboratories, Inc.; SeraCare Life Sciences; Genocea Biosciences; Cepheid; Gen-Probe; National Institutes of Health; Gilead Sciences; STD prevention and control services; San Francisco city and county; Centers for Disease Control and Prevention; state of California; McGraw Hill Companies FX Funded in part by U.S. Public Health Service T32 grant AI007641-06A2.; Dr. Barry received a salary from the U.S. Public Health Service, was supported in part by a training grant (T32 grant AI007641-06A2), and received research support from Forest Laboratories, Inc., for a project unassociated with this article. Dr. Philip received research support from SeraCare Life Sciences, Genocea Biosciences, Cepheid, Gen-Probe, National Institutes of Health, and Gilead Sciences; received honoraria from Gilead Sciences for an internal presentation to Gilead scientists on hepatitis B virus screening in STD clinics; and received travel or accommodation expenses covered or reimbursed by Gen-Probe for travel to the International Society for Sexually Transmitted Diseases Research meeting in July 2009. Dr. Klausner reports receiving the following grants or grants pending: an annual grant for STD prevention and control services, San Francisco city and county, from the Centers for Disease Control and Prevention, various research grants for study participation from the National Institutes of Health, HIV/AIDS research program from the state of California, test kits from Gen-Probe, and research support from Forest Laboratories; he receives annual royalties from McGraw Hill Companies (Columbus, OH) for the textbook Current Clinical Diagnosis and Management of Sexually Transmitted Diseases. Dr. Kent did not report any potential conflicts of interest. NR 31 TC 24 Z9 24 U1 3 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2010 VL 115 IS 4 BP 753 EP 759 DI 10.1097/AOG.0b013e3181d444f6 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 580QH UT WOS:000276463700012 PM 20308835 ER PT J AU Jalovecka, M Sak, B Kvac, M Kvetonova, D Kucerova, Z Salat, J AF Jalovecka, Marie Sak, Bohumil Kvac, Martin Kvetonova, Dana Kucerova, Zuzana Salat, Jiri TI Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice SO PARASITOLOGY RESEARCH LA English DT Article ID GUT INTRAEPITHELIAL LYMPHOCYTES; DELTA T-CELLS; PARVUM INFECTION; GAMMA-INTERFERON; NUDE-MICE; OOCYSTS; ROLES AB Gastric cryptosporidia only inhabit the glandular part of the stomach of all age categories of their hosts and can cause chronic life-long infections independent of a host's immune status. The immune response in the stomach mucosa during the primary infection and re-infection with Cryptosporidium muris (TS03 and CB03) in immunocompetent BALB/c mice was characterized using flow cytometry analysis and measurement of IFN-gamma and IL10 by enzyme-linked immunosorbent assays (ELISA). Significantly, elevated migration of T lymphocytes (more than 1,000-fold), especially CD8+ T lymphocytes, to the stomach mucosa occurred during primary infection and persisted for more than 2 months after its resolution. The ex vivo cultures of splenocytes revealed very low levels of IFN-gamma production during the course of the primary infection (0.5 ng/ml), whereas in the following re-exposure to the parasites, the concentration of IFN-gamma rapidly increased 22-fold. Although the two parasite strains that were tested were genetically distinct, they yielded similar results in the induction of cellular immune responses, suggesting that these patterns are not unique to a single parasite strain. These results imply that the CD8+ T lymphocytes are involved in the immune response to gastric cryptosporidiosis and could play an important role in the elimination of C. muris infection in mice. C1 [Sak, Bohumil; Kvac, Martin; Kvetonova, Dana; Salat, Jiri] Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, CR-37005 Ceske Budejovice, Czech Republic. [Jalovecka, Marie; Salat, Jiri] Univ S Bohemia Ceske Budejovice, Fac Sci, Ceske Budejovice 37005, Czech Republic. [Kvac, Martin] Univ S Bohemia Ceske Budejovice, Fac Agr, Ceske Budejovice 37005, Czech Republic. [Kucerova, Zuzana] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Dept Hlth & Human Serv, Atlanta, GA 30341 USA. RP Sak, B (reprint author), Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, Branisovska 31, CR-37005 Ceske Budejovice, Czech Republic. EM casio@paru.cas.cz RI Kvac, Martin/G-7299-2014; Sak, Bohumil/G-9262-2014 OI Kvac, Martin/0000-0003-0013-6090; FU Agency of Academy of Sciences of the Czech Republic [KJB500960701]; Institute of Parasitology, Academy of Sciences of the Czech Republic [Z60220518] FX This work was supported by the Grant Agency of Academy of Sciences of the Czech Republic (project no. KJB500960701) and the Institute of Parasitology, Academy of Sciences of the Czech Republic (Z60220518). The findings and conclusions in this publication are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 32 TC 8 Z9 8 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 J9 PARASITOL RES JI Parasitol. Res. PD APR PY 2010 VL 106 IS 5 BP 1159 EP 1166 DI 10.1007/s00436-010-1785-2 PG 8 WC Parasitology SC Parasitology GA 577OU UT WOS:000276234300021 PM 20155366 ER PT J AU Johnson, VR Jacobson, KL Gazmararian, JA Blake, SC AF Johnson, Valerie R. Jacobson, Kara L. Gazmararian, Julie A. Blake, Sarah C. TI Does social support help limited-literacy patients with medication adherence? A mixed methods study of patients in the Pharmacy Intervention for Limited Literacy (PILL) Study SO PATIENT EDUCATION AND COUNSELING LA English DT Article DE Health literacy; Medication adherence; Patient-provider communication; Pharmacists; Social support ID LOW HEALTH LITERACY; ANTIRETROVIRAL THERAPY; MYOCARDIAL-INFARCTION; AFRICAN-AMERICAN; ELDERLY PERSONS; DRUG-THERAPY; CARE; MORTALITY; NONADHERENCE; PREDICTORS AB Objective: To explore whether social support helps patients with limited health literacy adhere to their medication regimens. Methods: We interviewed 275 pharmacy patients and assessed social support's influence on medication adherence for those with limited vs. adequate health literacy. We talked with patients (n = 26) and pharmacists (n = 7) to explore possible explanations for the quantitative findings. Results: Social support was associated with better medication adherence for patients with adequate health literacy but not those with limited health literacy (p < 0.05). When individual subscales for social support were analyzed, having a trusted confidant was the only type of social support associated with better medication adherence for limited-literacy patients (p < 0.05). Comments from patients and pharmacists suggest that limited-literacy patients were less likely to ask the pharmacists questions and infrequently brought relatives with them to the pharmacy. Conclusion: Unless they have a trusted confidant, limited-literacy patients might be reluctant to ask others for the kind of help needed to take their medicines correctly. Practice implications: Pharmacists need training to increase their awareness of limited health literacy and to communicate effectively with all patients, regardless of their literacy skills. To succeed, pharmacists also need the support of the health care systems where they work. Published by Elsevier Ireland Ltd. C1 [Johnson, Valerie R.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Jacobson, Kara L.; Blake, Sarah C.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. [Gazmararian, Julie A.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. RP Johnson, VR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mail Stop C-14, Atlanta, GA 30333 USA. EM vxj1@cdc.gov FU Robert Wood Johnson Foundation; Agency for Healthcare Research and Quality [290-00-0011] FX We gratefully acknowledge the members of the Pharmacy Intervention for Limited Literacy (PILL) Study Team; Sunil Kripalani, MD, MSc, for guiding the development of the PILL Study; Brian Schmotzer, MS, for help with statistical analysis methods; Daniel S. Budnitz, MD, MPH, for valuable feedback; and PEC peer-reviewers for their thoughtful review and guidance. This study was funded by the Robert Wood Johnson Foundation and the Agency for Healthcare Research and Quality (Contract No. 290-00-0011). NR 71 TC 22 Z9 22 U1 5 U2 15 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0738-3991 J9 PATIENT EDUC COUNS JI Patient Educ. Couns. PD APR PY 2010 VL 79 IS 1 BP 14 EP 24 DI 10.1016/j.pec.2009.07.002 PG 11 WC Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Public, Environmental & Occupational Health; Social Sciences - Other Topics GA 583RW UT WOS:000276698200004 PM 19647967 ER PT J AU Sood, BG Madan, A Saha, S Schendel, D Thorsen, P Skogstrand, K Hougaard, D Shankaran, S Carlo, W AF Sood, Beena G. Madan, Ashima Saha, Shampa Schendel, Diana Thorsen, Poul Skogstrand, Kristin Hougaard, David Shankaran, Seetha Carlo, Wally CA NICHD Neonatal Res Network TI Perinatal Systemic Inflammatory Response Syndrome and Retinopathy of Prematurity SO PEDIATRIC RESEARCH LA English DT Article ID NEUROTROPHIC FACTOR; DIABETIC-RETINOPATHY; PRETERM INFANTS; NEONATAL SEPSIS; GROWTH-FACTOR; MARKERS; BLOOD; SERUM; CHORIOAMNIONITIS; INTERLEUKIN-6 AB Fetal and neonatal inflammation is associated with several morbidities of prematurity. Its relationship to retinopathy of prematurity (ROP) has not been investigated. Our objective was to determine the relationship between cytokine levels and ROP in the first 3 postnatal wks. Data for this study were derived from the NICHD Cytokine Study. Dried blood spots (DBS) were obtained from infants <1000 g on days 0-1, 3 +/- 1, 7 +/- 2, 14 +/- 3, and 21 +/- 3. Infants were classified into three groups-no, mild, and severe ROP. Multiplex Luminex assay was used to quantify 20 cytokines. Temporal profiles of cytokines were evaluated using mixed-effects models after controlling for covariates. Of 1074 infants enrolled, 890 were examined for ROP and 877 included in the analysis. ROP was associated with several clinical characteristics on unadjusted analyses. Eight cytokines remained significantly different across ROP groups in adjusted analyses. IL-6 and IL-17 showed significant effects in early time periods (D0-3); TGF-beta, brain-derived neurotrophic factor (BDNF), and regulated on activation, normal T cell expressed and secreted (RANTES) in later time periods (D7-21) and IL-18, C-reactive protein (CRP), and neurotrophin-4 (NT-4) in both early and later time periods. We conclude that perinatal inflammation may be involved in the pathogenesis of ROP. (Pediatr Res 67: 394-400, 2010) C1 [Sood, Beena G.; Saha, Shampa] Wayne State Univ, Dept Pediat, Detroit, MI 48201 USA. [Madan, Ashima] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94305 USA. [Shankaran, Seetha] RTI Int, Stat & Epidemiol Unit, Res Triangle Pk, NC 27709 USA. [Schendel, Diana] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Thorsen, Poul] Univ Aarhus, Dept Epidemiol & Social Med, Aarhus, Denmark. [Thorsen, Poul] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Skogstrand, Kristin; Hougaard, David] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark. [Carlo, Wally] Univ Alabama, Dept Pediat, Birmingham, AL 35233 USA. RP Sood, BG (reprint author), Childrens Hosp Michigan, 3901 Beaubien Blvd,4H42, Detroit, MI 48201 USA. EM bsood@med.wayne.edu FU The National Institutes of Health [M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587]; Eunice Kennedy Shriver National Institute of Child Health and Human Development [U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27980, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689]; Centers for Disease Control and Prevention [Y1-HD-5000-01] FX Supported by The National Institutes of Health (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, and M01 RR16587), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27980, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 11134,0498, and U10 HD40689), and the Centers for Disease Control and Prevention (Interagency Agreement Y1-HD-5000-01) provided grant support for recruitment (for 1991) 2001 and data analysis for the Neonatal Research Network's Cytokines Study. The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies. NR 37 TC 54 Z9 59 U1 2 U2 8 PU INT PEDIATRIC RESEARCH FOUNDATION, INC PI BALTIMORE PA 351 W CAMDEN ST, BALTIMORE, MD 21201-2436 USA SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 2010 VL 67 IS 4 BP 394 EP 400 PG 7 WC Pediatrics SC Pediatrics GA 573AU UT WOS:000275881600011 PM 20032809 ER PT J AU Perrine, CG Sharma, AJ Jefferds, MED Serdula, MK Scanlon, KS AF Perrine, Cria G. Sharma, Andrea J. Jefferds, Maria Elena D. Serdula, Mary K. Scanlon, Kelley S. TI Adherence to Vitamin D Recommendations Among US Infants SO PEDIATRICS LA English DT Article DE American Academy of Pediatrics; vitamin D; Infant Feeding Practices Study II; supplement ID D DEFICIENCY; UNITED-STATES; NUTRITIONAL RICKETS; FEEDING PRACTICES; CHILDREN; MILK; SUPPLEMENTATION; ADOLESCENTS; PREVENTION; PREVALENCE AB OBJECTIVES: In November 2008, the American Academy of Pediatrics (AAP) doubled the recommended daily intake of vitamin D for infants and children, from 200 IU/day (2003 recommendation) to 400 IU/day. We aimed to assess the prevalence of infants meeting the AAP recommended intake of vitamin D during their first year of life. METHODS: Using data from the Infant Feeding Practices Study II, conducted from 2005 to 2007, we estimated the percentage of infants who met vitamin D recommendations at ages 1, 2, 3, 4, 5, 6, 7.5, 9, and 10.5 months (n = 1952-1633). RESULTS: The use of oral vitamin D supplements was low, regardless of whether infants were consuming breast milk or formula, ranging from 1% to 13%, varying by age. Among infants who consumed breast milk but no formula, only 5% to 13% met either recommendation. Among mixed-fed infants, 28% to 35% met the 2003 recommendation, but only 9% to 14% would have met the 2008 recommendation. Among those who consumed formula but no breast milk, 81% to 98% met the 2003 recommendation, but only 20% to 37% would have met the 2008 recommendation. CONCLUSIONS: Our findings suggest that most US infants are not consuming adequate amounts of vitamin D according to the 2008 AAP recommendation. Pediatricians and health care providers should encourage parents of infants who are either breastfed or consuming <1 L/day of infant formula to give their infants an oral vitamin D supplement. Pediatrics 2010;125:627-632 C1 [Perrine, Cria G.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Perrine, Cria G.; Sharma, Andrea J.; Jefferds, Maria Elena D.; Serdula, Mary K.; Scanlon, Kelley S.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Perrine, CG (reprint author), 4770 Buford Hwy NE,MS K-25, Atlanta, GA 30341 USA. EM cgregory@cdc.gov OI Sharma, Andrea/0000-0003-0385-0011 FU National Institutes of Health (NIH) FX Funded by the National Institutes of Health (NIH). NR 29 TC 36 Z9 42 U1 0 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP 627 EP 632 DI 10.1542/peds.2009-2571 PG 6 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600003 PM 20308221 ER PT J AU Cole, CR Grant, FK Tangpricha, V Swaby-Ellis, ED Smith, JL Jacques, A Chen, HP Schleicher, RL Ziegler, TR AF Cole, Conrad R. Grant, Frederick K. Tangpricha, Vin Swaby-Ellis, E. Dawn Smith, Joy L. Jacques, Anne Chen, Huiping Schleicher, Rosemary L. Ziegler, Thomas R. TI 25-Hydroxyvitamin D Status of Healthy, Low-Income, Minority Children in Atlanta, Georgia SO PEDIATRICS LA English DT Article DE vitamin D; 25-hydroxvitamin D; low-income; minority; preschool; children ID VITAMIN-D DEFICIENCY; NUTRITIONAL RICKETS; UNITED-STATES; INFANTS; CALCIUM; RISK; ADOLESCENTS; PREVENTION; MOTHERS; CANCER AB OBJECTIVES: The goals were to determine the prevalence of vitamin D deficiency among minority children in a southern US city, to examine differences in serum 25-hydroxyvitamin D levels between non-Hispanic black and Hispanic children, and to determine dietary sources of vitamin D. METHODS: Low-income, minority children (N = 290; mean age: 2.5 +/- 1.2 years) were recruited during well-child clinic visits. Serum 25-hydroxyvitamin D and calcium levels were measured and dietary information was assessed. RESULTS: The mean 25-hydroxyvitamin D(3) level was 26.2 +/- 7.6 ng/mL, whereas 25-hydroxyvitamin D(2) was not detected. Overall, 22.3% of children had deficient serum 25-hydroxyvitamin D(3) levels (<= 20 ng/mL), 73.6% had less-than-optimal serum 25-hydroxyvitamin D levels (<= 30 ng/mL), and 1.4% had low serum calcium levels (<= 9 mg/dL). A significantly larger proportion of non-Hispanic black children, compared with Hispanic children, had vitamin D deficiency (26% vs 18%; P < .05). Age and season of recruitment were significantly associated with vitamin D deficiency and low serum calcium levels. Older children (>= 3 years) were less likely to have vitamin D deficiency (odds ratio [ OR]: 0.89 [95% confidence interval [CI]: 0.81-0.96]; P < .001). Study enrollment during spring and summer reduced the likelihood of vitamin D deficiency by similar to 20% (spring, OR: 0.85 [95% CI: 0.73-0.98]; P = .03; summer, OR: 0.82 [ 95% CI: 0.73-0.92]; P < .01). Fortified milk provided most dietary vitamin D (62%), with Hispanic children reporting greater intake. CONCLUSIONS: Suboptimal vitamin D status was common among apparently healthy, low-income, minority children. Age and season were significant predictors of vitamin D deficiency. Pediatrics 2010; 125: 633639 C1 [Cole, Conrad R.] Emory Univ, Sch Med, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, Atlanta, GA 30322 USA. [Tangpricha, Vin; Ziegler, Thomas R.] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA. [Cole, Conrad R.; Grant, Frederick K.; Tangpricha, Vin; Ziegler, Thomas R.] Emory Univ, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA. [Swaby-Ellis, E. Dawn] Grady Mem Hosp, Dept Community Med, Atlanta, GA USA. [Chen, Huiping; Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Cole, CR (reprint author), Emory Univ, Sch Med, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, 2015 Uppergate Dr, Atlanta, GA 30322 USA. EM crcole@emory.edu RI Tangpricha, Vin/A-8645-2009 FU Centers for Disease Control and Prevention; Centers for Disease Control and Prevention/Robert W. Woodruff Foundation; National Institutes of Health National Center [M01 RR00039, UL1 RR025008, K12 RR017643/KL2 RR025009, K24 RR023356] FX This work was supported in part by a Centers for Disease Control and Prevention/Robert W. Woodruff Foundation Young Investigator in Public Health grant (to Dr Cole), with scientific and technical assistance from the Centers for Disease Control and Prevention, and by National Institutes of Health National Center for Research Resources grants M01 RR00039 (General Clinical Research Center program), UL1 RR025008 (Clinical and Translational Science Awards program), K12 RR017643/KL2 RR025009 (to Dr Cole), and K24 RR023356 (to Dr Ziegler). NR 29 TC 31 Z9 33 U1 0 U2 6 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP 633 EP 639 DI 10.1542/peds.2009-1928 PG 7 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600004 PM 20351012 ER PT J AU Kogan, MD Newacheck, PW Blumberg, SJ Heyman, KM Strickland, BB Singh, GK Zeni, MB AF Kogan, Michael D. Newacheck, Paul W. Blumberg, Stephen J. Heyman, Kathleen M. Strickland, Bonnie B. Singh, Gopal K. Zeni, Mary Beth TI State Variation in Underinsurance Among Children With Special Health Care Needs in the United States SO PEDIATRICS LA English DT Article DE underinsurance; children with special health care needs; national estimates; state-level estimates; geographic disparity ID TRENDS AB OBJECTIVE: National attention has focused on providing health insurance coverage for children. Less awareness has been given to underinsurance, particularly for children with special health care needs (CSHCN). Defined as having inadequate benefits, underinsurance may be a particular problem for CSHCN because of their greater needs for medical care. METHODS: We used the 2005-2006 National Survey of Children With Special Health Care Needs, a nationally representative study of >40 000 CSHCN, to address state variations in underinsurance. CSHCN with health insurance were considered underinsured when a parent reported that the child's insurance did not usually or always cover needed services and providers or reasonably cover costs. We calculated the unadjusted prevalence of underinsurance for each state. Using logistic regression, we estimated state-specific odds and prevalence for underinsurance after adjusting for poverty level, race/ethnicity, gender, family structure, language use, insurance type, and severity of child's health condition. We also conducted multilevel analyses incorporating state-level contextual data on Medicaid and the State Children's Health Insurance Program. RESULTS: Bivariate and multivariate analyses indicated that CSHCN's state of residence had a strong association with insurance adequacy. State-level unadjusted underinsurance rates ranged from 24% (Hawaii) to 38% (Illinois). After multivariate adjustments, the range was largely unchanged: 23% (Hawaii) to 38% (New Jersey). Multilevel analyses indicated that Medicaid income eligibility levels were inversely associated with the odds of being underinsured. CONCLUSIONS: The individual-level and macro-level factors examined only partly explain state variations in underinsurance. Furthermore, the macro-level factors explained only a small portion of the variance; however, other macro-level factors may be relevant for the observed patterns. Pediatrics 2010;125:673-680 C1 [Kogan, Michael D.; Strickland, Bonnie B.; Singh, Gopal K.] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Newacheck, Paul W.] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA. [Newacheck, Paul W.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA. [Blumberg, Stephen J.; Heyman, Kathleen M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Zeni, Mary Beth] Florida State Univ, Coll Nursing, Tallahassee, FL 32306 USA. RP Kogan, MD (reprint author), US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, 5600 Fishers La,Room 18-41, Rockville, MD 20857 USA. EM mkogan@hrsa.gov NR 18 TC 15 Z9 15 U1 0 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP 673 EP 680 DI 10.1542/peds.2009-1055 PG 8 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600010 PM 20211947 ER PT J AU Willis, BC Wortley, P Wang, SA Jacques-Carroll, L Zhang, F AF Willis, Bayo C. Wortley, Pascale Wang, Susan A. Jacques-Carroll, Lisa Zhang, Fan TI Gaps in Hospital Policies and Practices to Prevent Perinatal Transmission of Hepatitis B Virus SO PEDIATRICS LA English DT Article DE immunization; perinatal hepatitis B virus; hepatitis B vaccine ID VACCINATION AB OBJECTIVE: The objective of this study was to examine hospital policies and practices to prevent perinatal transmission of hepatitis B virus (HBV) in the United States and to and identify gaps. METHODS: In March 2006, a nationally representative sample of 242 delivery hospitals in the 50 states, District of Columbia, and Puerto Rico (with at least 100 annual births) were surveyed about hospital perinatal hepatitis B prevention policies and asked to review paired maternal-infant medical records for 25 consecutive live births. Main outcome measures were hospital policies related to the prevention of perinatal transmission of hepatitis B and the proportion of infants who received recommended care. RESULTS: A total of 190 of 242 hospitals responded to the survey and completed medical record reviews for 4762 mothers and 4786 infants. The proportion of hospitals that reported each of the 6 policies examined ranged from 63.0% to 80.6%. Among infants who were born to the 18 hepatitis B surface antigen (HBsAg)-positive women with documented prenatal test results, 62.1% received both hepatitis B vaccine and hepatitis B immunoglobulin within 12 hours, but 13.7% were unvaccinated and 19.7% did not receive hepatitis B immunoglobulin before hospital discharge. Among infants who were born to the 320 women with unknown HBsAg status, only 52.4% were vaccinated within 12 hours of birth and 20.1% were unvaccinated before discharge. Among infants who were born to HBsAg-negative mothers, 69.1% received the hepatitis B vaccine before hospital discharge. The strongest predictor of vaccine administration was having a written hospital policy for newborn hepatitis B vaccination. CONCLUSIONS: These findings indicate that significant gaps persist in hospital policies and practices to prevent perinatal HBV transmission in the United States. Efforts to avoid medical errors through appropriate implementation and monitoring of hospital practices are needed to eliminate perinatal HBV transmission. Pediatrics 2010;125:704-711 C1 [Willis, Bayo C.; Wortley, Pascale; Jacques-Carroll, Lisa; Zhang, Fan] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA 30333 USA. [Wang, Susan A.] Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Wang, Susan A.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA 30333 USA. RP Willis, BC (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, 1600 Clifton Rd,MS E52, Atlanta, GA 30333 USA. EM bnw6@cdc.gov NR 20 TC 22 Z9 23 U1 1 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP 704 EP 711 DI 10.1542/peds.2009-1831 PG 8 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600014 PM 20211952 ER PT J AU Sugerman, DE Barskey, AE Delea, MG Ortega-Sanchez, IR Bi, DL Ralston, KJ Rota, PA Waters-Montijo, K LeBaron, CW AF Sugerman, David E. Barskey, Albert E. Delea, Maryann G. Ortega-Sanchez, Ismael R. Bi, Daoling Ralston, Kimberly J. Rota, Paul A. Waters-Montijo, Karen LeBaron, Charles W. TI Measles Outbreak in a Highly Vaccinated Population, San Diego, 2008: Role of the Intentionally Undervaccinated SO PEDIATRICS LA English DT Article DE measles vaccine; disease outbreaks; vaccine-preventable diseases; vaccine refusal; vaccination coverage ID SCHOOL IMMUNIZATION REQUIREMENTS; UNITED-STATES; CHILDREN; EXEMPTIONS; CALIFORNIA; COVERAGE; POLICIES; LAWS AB OBJECTIVE: In January 2008, an intentionally unvaccinated 7-year-old boy who was unknowingly infected with measles returned from Switzerland, resulting in the largest outbreak in San Diego, California, since 1991. We investigated the outbreak with the objective of understanding the effect of intentional undervaccination on measles transmission and its potential threat to measles elimination. METHODS: We mapped vaccination-refusal rates according to school and school district, analyzed measles-transmission patterns, used discussion groups and network surveys to examine beliefs of parents who decline vaccination, and evaluated containment costs. RESULTS: The importation resulted in 839 exposed persons, 11 additional cases (all in unvaccinated children), and the hospitalization of an infant too young to be vaccinated. Two-dose vaccination coverage of 95%, absence of vaccine failure, and a vigorous outbreak response halted spread beyond the third generation, at a net public-sector cost of $10 376 per case. Although 75% of the cases were of persons who were intentionally unvaccinated, 48 children too young to be vaccinated were quarantined, at an average family cost of $775 per child. Substantial rates of intentional undervaccination occurred in public charter and private schools, as well as public schools in upper-socioeconomic areas. Vaccine refusal clustered geographically and the overall rate seemed to be rising. In discussion groups and survey responses, the majority of parents who declined vaccination for their children were concerned with vaccine adverse events. CONCLUSIONS: Despite high community vaccination coverage, measles outbreaks can occur among clusters of intentionally undervaccinated children, at major cost to public health agencies, medical systems, and families. Rising rates of intentional undervaccination can undermine measles elimination. Pediatrics 2010;125:747-755 C1 [Sugerman, David E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Barskey, Albert E.; Ortega-Sanchez, Ismael R.; Bi, Daoling; Rota, Paul A.; LeBaron, Charles W.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Delea, Maryann G.] Council State & Territorial Epidemiologists, Atlanta, GA USA. [Ralston, Kimberly J.; Waters-Montijo, Karen] Cty San Diego Hlth & Human Serv Agcy, Immunizat Branch, San Diego, CA USA. RP Sugerman, DE (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, 1600 Clifton Rd NE,Mail Stop E-05, Atlanta, GA 30333 USA. EM ggi4@cdc.gov NR 30 TC 110 Z9 117 U1 3 U2 24 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP 747 EP 755 DI 10.1542/peds.2009-1653 PG 9 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600020 PM 20308208 ER PT J AU Kim, NH Pavkov, ME Knowler, WC Hanson, RL Weil, EJ Curtis, JM Bennett, PH Nelson, RG AF Kim, Nan Hee Pavkov, Meda E. Knowler, William C. Hanson, Robert L. Weil, E. Jennifer Curtis, Jeffrey M. Bennett, Peter H. Nelson, Robert G. TI Predictive Value of Albuminuria in American Indian Youth With or Without Type 2 Diabetes SO PEDIATRICS LA English DT Article DE diabetic nephropathy; epidemiology; incidence; longitudinal; prevalence; risk factors ID GLOMERULAR-FILTRATION-RATE; PIMA-INDIANS; GLUCOSE-TOLERANCE; RENAL-DISEASE; MELLITUS; MICROALBUMINURIA; PREVALENCE; CHILDREN; COMPLICATIONS; NEPHROPATHY AB OBJECTIVE: To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 <= albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbuminuria (ACR >= 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14 (7.1%) diabetic youth with an elevated ACR (>= 30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% confidence interval: 11.1-22.6) higher in the diabetic than in the nondiabetic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely transient in nondiabetic youth, but it is relatively frequent and largely persistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria. Pediatrics 2010; 125: e844-e851 C1 [Kim, Nan Hee; Pavkov, Meda E.; Knowler, William C.; Hanson, Robert L.; Weil, E. Jennifer; Curtis, Jeffrey M.; Bennett, Peter H.; Nelson, Robert G.] NIDDKD, Diabet Epidemiol & Clin Res Sect, NIH, Phoenix, AZ 85014 USA. [Kim, Nan Hee] Korea Univ, Sch Med, Dept Endocrinol & Metab, Seoul, South Korea. [Pavkov, Meda E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Nelson, RG (reprint author), NIDDKD, Diabet Epidemiol & Clin Res Sect, NIH, 1550 E Indian Sch Rd, Phoenix, AZ 85014 USA. EM rnelson@nih.gov RI Nelson, Robert/B-1470-2012; Hanson, Robert/O-3238-2015 OI Hanson, Robert/0000-0002-4252-7068 FU National Institute of Diabetes and Digestive and Kidney Diseases FX This research was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. NR 43 TC 11 Z9 11 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2010 VL 125 IS 4 BP E844 EP E851 DI 10.1542/peds.2009-1230 PG 8 WC Pediatrics SC Pediatrics GA 577QR UT WOS:000276239600053 PM 20194283 ER PT J AU Addiss, DG Louis-Charles, J Roberts, J LeConte, F Wendt, JM Milord, MD Lammie, PJ Dreyer, G AF Addiss, David G. Louis-Charles, Jacky Roberts, Jacquelin LeConte, Frederic Wendt, Joyanna M. Milord, Marie Denise Lammie, Patrick J. Dreyer, Gerusa TI Feasibility and Effectiveness of Basic Lymphedema Management in Leogane, Haiti, an Area Endemic for Bancroftian Filariasis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID LYMPHATIC FILARIASIS; ACUTE ADENOLYMPHANGITIS; BRUGIAN FILARIASIS; EPISODIC ADENOLYMPHANGITIS; ACUTE ATTACKS; AFFECTED-LIMB; PROGRAM; EFFICACY; DIETHYLCARBAMAZINE; ELEPHANTIASIS AB Background: Approximately 14 million persons living in areas endemic for lymphatic filariasis have lymphedema of the leg. Clinical studies indicate that repeated episodes of bacterial acute dermatolymphangioadenitis (ADLA) lead to progression of lymphedema and that basic lymphedema management, which emphasizes hygiene, skin care, exercise, and leg elevation, can reduce ADLA frequency. However, few studies have prospectively evaluated the effectiveness of basic lymphedema management or assessed the role of compressive bandaging for lymphedema in resource-poor settings. Methodology/Principal Findings: Between 1995 and 1998, we prospectively monitored ADLA incidence and leg volume in 175 persons with lymphedema of the leg who enrolled in a lymphedema clinic in Leogane, Haiti, an area endemic for Wuchereria bancrofti. During the first phase of the study, when a major focus of the program was to reduce leg volume using compression bandages, ADLA incidence was 1.56 episodes per person-year. After March 1997, when hygiene and skin care were systematically emphasized and bandaging discouraged, ADLA incidence decreased to 0.48 episodes per person-year (P < 0.0001). ADLA incidence was significantly associated with leg volume, stage of lymphedema, illiteracy, and use of compression bandages. Leg volume decreased in 78% of patients; over the entire study period, this reduction was statistically significant only for legs with stage 2 lymphedema (P = 0.01). Conclusions/Significance: Basic lymphedema management, which emphasized hygiene and self-care, was associated with a 69% reduction in ADLA incidence. Use of compression bandages in this setting was associated with an increased risk of ADLA. Basic lymphedema management is feasible and effective in resource-limited areas that are endemic for lymphatic filariasis. C1 [Addiss, David G.; Roberts, Jacquelin; Wendt, Joyanna M.; Lammie, Patrick J.] US Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. [Addiss, David G.] Fetzer Inst, Kalamazoo, MI USA. [Louis-Charles, Jacky; LeConte, Frederic; Milord, Marie Denise] Hop Ste Croix, Leogane, Haiti. [Dreyer, Gerusa] Nongovt Org Amaury Coutinho, Recife, PE, Brazil. RP Addiss, DG (reprint author), US Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. EM daddiss@fetzer.org FU Office of Women's Health; U.S. Centers for Disease Control and Prevention, Atlanta, Georgia; WHO/UNDP/World Bank [950568]; St. Joseph's Hospital, Atlanta, Georgia FX This study was funded by grants from the Office of Women's Health (http://www.cdc.gov/women/), U.S. Centers for Disease Control and Prevention, Atlanta, Georgia; and the WHO/UNDP/World Bank Special Programme for Research and Training in Tropical Diseases (Filariasis Operational Research Project No. 950568) (http://apps.who.int/tdr/index.html). St. Joseph's Hospital (http://www.stjosephsatlanta.org), Atlanta, Georgia, provided a travel grant to Ian Roy to train staff at Ste. Croix Hospital, Haiti, in lymphedema management. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 16 Z9 16 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2010 VL 4 IS 4 AR e668 DI 10.1371/journal.pntd.0000668 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 590PX UT WOS:000277240400013 PM 20422031 ER PT J AU Gao, XY Nasci, R Liang, GD AF Gao, Xiaoyan Nasci, Roger Liang, Guodong TI The Neglected Arboviral Infections in Mainland China SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID TICK-BORNE ENCEPHALITIS; CONGO HEMORRHAGIC-FEVER; IMMUNOGLOBULIN-G ANTIBODIES; REPUBLIC-OF-CHINA; JAPANESE-ENCEPHALITIS; RECOMBINANT NUCLEOPROTEIN; VIRUS; DENGUE; SEQUENCE; ASIA AB The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively neglected disease burden in China. Here we briefly review the literature regarding these arboviral infections in mainland China with emphasis on their epidemiology, primary vectors, phylogenetic associations, and the prevention programs associated with these agents in China. C1 [Gao, Xiaoyan; Liang, Guodong] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Control & Prevent, Beijing, Peoples R China. [Nasci, Roger] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Gao, XY (reprint author), Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Control & Prevent, Beijing, Peoples R China. EM gdliang@hotmail.com FU Ministry of Science and Technology, China [2003BA712A08-01, 2008ZX10004-001]; State Key Laboratory for Infectious Disease Prevention and Control [2008SKLID105]; China CDC-US CDC [U19-GH000004] FX This work was supported by grants from the Ministry of Science and Technology, China (No. 2003BA712A08-01 and 2008ZX10004-001); Development Grant of State Key Laboratory for Infectious Disease Prevention and Control (2008SKLID105) and China CDC-US CDC Cooperative Agreement U19-GH000004. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 94 TC 63 Z9 82 U1 2 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2010 VL 4 IS 4 AR e624 DI 10.1371/journal.pntd.0000624 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 590PX UT WOS:000277240400004 PM 20436960 ER PT J AU Westenberger, SJ McClean, CM Chattopadhyay, R Dharia, NV Carlton, JM Barnwell, JW Collins, WE Hoffman, SL Zhou, YY Vinetz, JM Winzeler, EA AF Westenberger, Scott J. McClean, Colleen M. Chattopadhyay, Rana Dharia, Neekesh V. Carlton, Jane M. Barnwell, John W. Collins, William E. Hoffman, Stephen L. Zhou, Yingyao Vinetz, Joseph M. Winzeler, Elizabeth A. TI A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HUMAN MALARIA PARASITE; TRYPTOPHAN-RICH ANTIGEN; PATTERN IDENTIFICATION; CHLOROQUINE RESISTANCE; MULTIGENE SUPERFAMILY; EXPRESSION PATTERNS; TOXOPLASMA-GONDII; VARIANT PROTEINS; GENE-EXPRESSION; BLOOD STAGES AB Background: Up to 40% of the world's population is at risk for Plasmodium vivax malaria, a disease that imposes a major public health and economic burden on endemic countries. Because P. vivax produces latent liver forms, eradication of P. vivax malaria is more challenging than it is for P. falciparum. Genetic analysis of P. vivax is exceptionally difficult due to limitations of in vitro culture. To overcome the barriers to traditional molecular biology in P. vivax, we examined parasite transcriptional changes in samples from infected patients and mosquitoes in order to characterize gene function, define regulatory sequences and reveal new potential vaccine candidate genes. Principal Findings: We observed dramatic changes in transcript levels for various genes at different lifecycle stages, indicating that development is partially regulated through modulation of mRNA levels. Our data show that genes involved in common biological processes or molecular machinery are co-expressed. We identified DNA sequence motifs upstream of co-expressed genes that are conserved across Plasmodium species that are likely binding sites of proteins that regulate stage-specific transcription. Despite their capacity to form hypnozoites we found that P. vivax sporozoites show stage-specific expression of the same genes needed for hepatocyte invasion and liver stage development in other Plasmodium species. We show that many of the predicted exported proteins and members of multigene families show highly coordinated transcription as well. Conclusions: We conclude that high-quality gene expression data can be readily obtained directly from patient samples and that many of the same uncharacterized genes that are upregulated in different P. vivax lifecycle stages are also upregulated in similar stages in other Plasmodium species. We also provide numerous examples of how systems biology is a powerful method for determining the likely function of genes in pathogens that are neglected due to experimental intractability. C1 [Westenberger, Scott J.; Dharia, Neekesh V.; Winzeler, Elizabeth A.] Scripps Res Inst, Dept Cell Biol ICND 202, La Jolla, CA 92037 USA. [McClean, Colleen M.; Vinetz, Joseph M.] Univ Calif San Diego, Sch Med, Dept Med, Div Infect Dis, La Jolla, CA 92093 USA. [Chattopadhyay, Rana; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Carlton, Jane M.] NYU, Dept Med Parasitol, Langone Med Ctr, New York, NY USA. [Barnwell, John W.; Collins, William E.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Zhou, Yingyao] Novartis Res Fdn, Genom Inst, San Diego, CA USA. RP Westenberger, SJ (reprint author), Scripps Res Inst, Dept Cell Biol ICND 202, La Jolla, CA 92037 USA. EM winzeler@scripps.edu OI McClean, Colleen/0000-0002-1698-1136; Vinetz, Joseph/0000-0001-8344-2004; Winzeler, Elizabeth/0000-0002-4049-2113 FU NIH [1F32AI074242-01A1, R01GM070793, 1K24AI068903, 1R01AI067727, R01AI059472-02]; Medicines for Malaria Venture; Wellcome Trust; Keck Foundation FX SJW was supported by NIH grant 1F32AI074242-01A1. JMC was supported by NIH grant R01GM070793. JMV and CMM were supported by NIH grants 1K24AI068903 and 1R01AI067727. Funding from Medicines for Malaria Venture and the Wellcome Trust supported these studies and SLH. EAW was supported by the Keck Foundation and NIH grant R01AI059472-02. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 65 TC 55 Z9 55 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2010 VL 4 IS 4 AR e653 DI 10.1371/journal.pntd.0000653 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 590PX UT WOS:000277240400023 PM 20386602 ER PT J AU Okoro, CA Strine, TW Balluz, LS Crews, JE Mokdad, AH AF Okoro, Catherine A. Strine, Tara W. Balluz, Lina S. Crews, John E. Mokdad, Ali H. TI Prevalence and correlates of depressive symptoms among United States adults with disabilities using assistive technology SO PREVENTIVE MEDICINE LA English DT Article DE Disability; Assistive technology; Assistive devices; Special equipment; Depressive symptoms; Anxiety disorders; Smoking; Epidemiology; Age; BRFSS ID AFRICAN-AMERICANS; OLDER-PEOPLE; US ADULTS; ANXIETY; RISK; DEVICES; HEALTH; REHABILITATION; PREDICTORS; DISEASE AB Objectives. To estimate the prevalence of current depressive symptoms (CDS) among adults that reported disabilities requiring the use of assistive technology (AT) and those that did not, and to examine the sociodemographic, comorbidity, health behavior, and social support correlates of this condition in adults who use AT. Methods. Data from the 2006 Behavioral Risk Factor Surveillance System, a standardized telephone survey among U.S. adults, were analyzed (n =195,033). The Patient Health Questionnaire diagnostic algorithm was used to identify CDS. Results. AT users were significantly more likely than AT non-users to have CDS (age-standardized: 30.4% vs. 7.4%). Among AT users, there was a dose response relationship between depression severity and increased prevalence of health conditions, obesity, smoking, and physical inactivity. In the full covariate logistic regression model, the strongest sociodemographic variables associated with CDS among AT users were age and employment status. Other variables strongly associated with CDS were lack of social support and anxiety. Conclusions. An integrated approach to health care should be taken with adults who use AT. AT service providers, primary health care providers, and other care givers should be alert to the possibility of depression in AT users: and opportunities to prevent, detect, and treat depression among this population should not be missed. Published by Elsevier Inc. C1 [Okoro, Catherine A.; Strine, Tara W.; Balluz, Lina S.; Mokdad, Ali H.] US Ctr Dis Control & Prevent, Behav Surveillance Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Crews, John E.] US Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA. RP Okoro, CA (reprint author), US Ctr Dis Control & Prevent, Behav Surveillance Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K66, Atlanta, GA 30341 USA. EM Cokoro@cdc.gov NR 49 TC 5 Z9 6 U1 1 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD APR PY 2010 VL 50 IS 4 BP 204 EP 209 DI 10.1016/j.ypmed.2010.01.008 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 574OR UT WOS:000276000800009 PM 20100508 ER PT J AU Redd, SC Frieden, TR Schuchat, A Briss, PA AF Redd, Stephen C. Frieden, Thomas R. Schuchat, Anne Briss, Peter A. TI 1918 AND 2009: A TALE OF TWO PANDEMICS SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Redd, Stephen C.] Ctr Dis Control & Prevent, Influenza Coordinat Unit, Atlanta, GA 30333 USA. RP Redd, SC (reprint author), Ctr Dis Control & Prevent, Influenza Coordinat Unit, 1600 Clifton Rd,NE,MS A-20, Atlanta, GA 30333 USA. EM scr1@cdc.gov NR 2 TC 1 Z9 1 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD APR PY 2010 VL 125 SU 3 BP 3 EP 5 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 601BV UT WOS:000278033900001 PM 20568563 ER PT J AU Stern, AM Cetron, MS Markel, H AF Stern, Alexandra Minna Cetron, Martin S. Markel, Howard TI THE 1918-1919 INFLUENZA PANDEMIC IN THE UNITED STATES: LESSONS LEARNED AND CHALLENGES EXPOSED SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Stern, Alexandra Minna] Univ Michigan, Sch Med, Simpson Mem Inst 100, Ctr Hist Med, Ann Arbor, MI 48109 USA. [Cetron, Martin S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. RP Stern, AM (reprint author), Univ Michigan, Sch Med, Simpson Mem Inst 100, Ctr Hist Med, 102 Observ St, Ann Arbor, MI 48109 USA. EM amstern@umich.edu FU NHLBI NIH HHS [000HCVKC-2007-44323] NR 1 TC 1 Z9 1 U1 0 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD APR PY 2010 VL 125 SU 3 BP 6 EP 8 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 601BV UT WOS:000278033900002 PM 20568564 ER PT J AU Stern, AM Reilly, MB Cetron, MS Markel, H AF Stern, Alexandra Minna Reilly, Mary Beth Cetron, Martin S. Markel, Howard TI "Better Off in School": School Medical Inspection as a Public Health Strategy During the 1918-1919 Influenza Pandemic in the United States SO PUBLIC HEALTH REPORTS LA English DT Article AB During the 1918-1919 influenza pandemic in the United States, most cities responded by implementing community mitigation strategies, such as school closure. However, three cities New York City, Chicago, and New Haven, Connecticut diverged from the dominant pattern by keeping their public schools open while the pandemic raged. This article situates the experiences of these three cities in the broader context of the Progressive era, when officials and experts put great faith in expanding public programs in health and education. It adds an important dimension to the historical understanding of the 1918-1919 influenza pandemic and offers lessons for public health practitioners and policymakers today who might face difficult decisions about how to respond to the 2009 H1N1 influenza pandemic. C1 [Stern, Alexandra Minna] Univ Michigan, Ctr Hist Med, Simpson Mem Inst 100, Ann Arbor, MI 48109 USA. [Cetron, Martin S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. RP Stern, AM (reprint author), Univ Michigan, Ctr Hist Med, Simpson Mem Inst 100, 102 Observ St, Ann Arbor, MI 48109 USA. EM amstern@umich.edu FU Robert Wood Johnson Foundation(R), Princeton, New Jersey; Centers for Disease Control and Prevention [000HCVKC-2007-44323] FX Dr. Stern and Dr. Markel received partial support for this project through an RWJF Investigator Award in Health Policy Research from the Robert Wood Johnson Foundation (R), Princeton, New Jersey, and the Centers for Disease Control and Prevention (Project No. 000HCVKC-2007-44323). NR 38 TC 3 Z9 3 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD APR PY 2010 VL 125 SU 3 BP 63 EP 70 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 601BV UT WOS:000278033900008 PM 20568692 ER PT J AU Kasper, DC Herman, J De Jesus, VR Mechtler, TP Metz, TF Shushan, B AF Kasper, David C. Herman, Joseph De Jesus, Victor R. Mechtler, Thomas P. Metz, Thomas F. Shushan, Bori TI The application of multiplexed, multi-dimensional ultra-high-performance liquid chromatography/tandem mass spectrometry to the high-throughput screening of lysosomal storage disorders in newborn dried bloodspots SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY LA English DT Article ID POMPE-DISEASE; SPOTS; ASSAY AB Lysozomal storage disorders are just beginning to be routinely screened using enzyme activity assays involving dried blood spots and tandem mass spectrometry (MS/MS). This paper discusses some of the analytical challenges associated with published assays including complex sample preparation and potential interference from excess residual substrate. Solutions to these challenges are presented in the form of on-line two-dimensional chromatography to eliminate off-line liquid-liquid extraction (LLE) and solid-phase extraction (SPE), the use of ultra-high-performance liquid chromatography (UHPLC) to separate excess substrate from all other analytes and multiplexed sample introduction for higher throughput required of a population screening assay. High sensitivity, specificity and throughput were demonstrated using this novel method. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Herman, Joseph] Thermo Fisher Sci, Franklin, MA 02038 USA. [Kasper, David C.; Mechtler, Thomas P.; Metz, Thomas F.] Med Univ Vienna, Dept Pediat & Adolescent Med, Vienna, Austria. [De Jesus, Victor R.] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Atlanta, GA 30341 USA. [Shushan, Bori] Clin Mass Spec Consultants, Toronto, ON M4W 2W6, Canada. RP Herman, J (reprint author), Thermo Fisher Sci, 101 Constitut Blvd, Franklin, MA 02038 USA. EM joseph.herman@thermofisher.com RI Kasper, David/B-9054-2012 NR 18 TC 27 Z9 27 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0951-4198 J9 RAPID COMMUN MASS SP JI Rapid Commun. Mass Spectrom. PD APR PY 2010 VL 24 IS 7 BP 986 EP 994 DI 10.1002/rcm.4496 PG 9 WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA 581BR UT WOS:000276496500018 PM 20209662 ER PT J AU Arbour, L Parkinson, A Kulig, JC AF Arbour, L. Parkinson, A. Kulig, J. C. TI Human health at the ends of the earth SO RURAL AND REMOTE HEALTH LA English DT Editorial Material ID RUSSIA C1 [Arbour, L.] Univ British Columbia, Med Genet & Isl Med Program, Vancouver, BC V5Z 1M9, Canada. [Parkinson, A.] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA. [Kulig, J. C.] Univ Lethbridge, Lethbridge, AB T1K 3M4, Canada. RP Arbour, L (reprint author), Univ British Columbia, Med Genet & Isl Med Program, Vancouver, BC V5Z 1M9, Canada. NR 26 TC 1 Z9 1 U1 0 U2 1 PU AUSTRALIAN RURAL HEALTH EDUC NETWORK PI DEAKIN WEST PA PO BOX 242, DEAKIN WEST, ACT 2600, AUSTRALIA SN 1445-6354 J9 RURAL REMOTE HEALTH JI Rural Remote Health PD APR-JUN PY 2010 VL 10 IS 2 AR 1534 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 708DT UT WOS:000286342500041 PM 20568905 ER PT J AU Margolis, KA AF Margolis, Katherine A. TI Underground coal mining injury: A look at how age and experience relate to days lost from work following an injury SO SAFETY SCIENCE LA English DT Article DE Coal mining; Injury; Age; Work experience ID OCCUPATIONAL ACCIDENTS; OLDER WORKERS; MULTIVARIATE; ILLNESSES; MINERS; SAFETY; BACK; RISK AB Coal has been mined in the United States since colonial times and coal mining has always been a dangerous occupation. Despite the dangers involved in coal mining, coal is essential to the functioning of our society. Coal provides energy for products, businesses, and homes. Not only is coal mining a dangerous occupation, but, like many other industries, coal mining has also been referred to as a "graying occupation" as many coal miners are reaching retirement age. Younger workers possess certain advantages as older workers may have age-associated decrements in cognitive function, health, and recuperative ability. Although there are documented decreases in health and safety associated with age, there are also benefits at the workplace associated with increasing age. Increasing age brings about more experience and familiarity with the work environment. This study used the Mine Safety and Health Administration's (MSHA) database on accidents, injury, and illness from the years 2003 through 2007 to examine how age, experience at the current mine, total years experience as a coal miner, and experience in the current job affects injury severity. The results of the data indicated that there was a relationship between age and days lost as well as total mining experience and days lost following an injury. Furthermore, the data indicated an increased risk of overexertion injuries as age increases. These are important findings for the coal mining industry as many miners are more experienced and older. Published by Elsevier Ltd. C1 NIOSH, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. RP Margolis, KA (reprint author), NIOSH, Ctr Dis Control & Prevent, POB 18070, Pittsburgh, PA 15236 USA. EM KMargolis@cdc.gov RI Banks, Tamara/G-3007-2012 NR 30 TC 9 Z9 9 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-7535 J9 SAFETY SCI JI Saf. Sci. PD APR PY 2010 VL 48 IS 4 BP 417 EP 421 DI 10.1016/j.ssci.2009.12.015 PG 5 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA 576BS UT WOS:000276119300001 ER PT J AU Lubar, D White, PH Callahan, LF Chang, RW Helmick, CG Lappin, DR Melnick, A Moskowitz, RW Odom, E Sacks, J Toal, SB Waterman, MB AF Lubar, Debra White, Patience H. Callahan, Leigh F. Chang, Rowland W. Helmick, Charles G. (Chad) Lappin, Debra R. Melnick, Amy Moskowitz, Roland W. Odom, Erica Sacks, Jeffrey Toal, Susan Baker Waterman, Mary B. TI A National Public Health Agenda for Osteoarthritis 2010 SO SEMINARS IN ARTHRITIS AND RHEUMATISM LA English DT Article C1 [Lubar, Debra; Helmick, Charles G. (Chad); Odom, Erica; Sacks, Jeffrey] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Callahan, Leigh F.] Univ N Carolina, Chapel Hill, NC 27515 USA. [Chang, Rowland W.] Northwestern Univ, Evanston, IL 60208 USA. [Moskowitz, Roland W.] Case Western Reserve Univ, Cleveland, OH 44106 USA. RP Lubar, D (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 0 TC 20 Z9 20 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0049-0172 J9 SEMIN ARTHRITIS RHEU JI Semin. Arthritis Rheum. PD APR PY 2010 VL 39 IS 5 BP 323 EP 326 DI 10.1016/j.semarthrit.2010.02.002 PG 4 WC Rheumatology SC Rheumatology GA 584LP UT WOS:000276753700002 PM 20307725 ER PT J AU Therrell, BL Schwartz, M Southard, C Williams, D Hannon, WH Mann, MY AF Therrell, Bradford L., Jr. Schwartz, Marion Southard, Carol Williams, Donna Hannon, W. Harry Mann, Marie Y. CA PEAS Organizing Working Grp TI Newborn Screening System Performance Evaluation Assessment Scheme (PEAS) SO SEMINARS IN PERINATOLOGY LA English DT Review DE newborn screening; quality assurance; system; performance; indicators ID REGIONAL-NETWORKS; GENETIC-SERVICES; FOLLOW-UP; STATEMENT; GUIDELINES; COMPONENTS; DIAGNOSIS; CHILDREN; COUNCIL C1 [Therrell, Bradford L., Jr.; Schwartz, Marion; Southard, Carol; Williams, Donna] Natl Newborn Screening & Genet Ctr, Austin, TX USA. [Therrell, Bradford L., Jr.; Schwartz, Marion; Southard, Carol; Williams, Donna] Univ Texas Hlth Ctr San Antonio, San Antonio, TX USA. [Hannon, W. Harry] Ctr Dis Control & Prevent, Newborn Screening Branch, Ctr Environm Hlth, Atlanta, GA USA. [Mann, Marie Y.] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. RP Therrell, BL (reprint author), Natl Newborn Screening & Genet Resource Ctr, 1912 W Anderson Lane, Austin, TX 78759 USA. EM therrell@uthscsa.edu FU HRSA [U32MC00148, U36MC02604] FX Supported in part by HRSA grants U32MC00148 and U36MC02604. NR 31 TC 9 Z9 10 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0146-0005 J9 SEMIN PERINATOL JI Semin. Perinatol. PD APR PY 2010 VL 34 IS 2 BP 105 EP 120 DI 10.1053/j.semperi.2009.12.002 PG 16 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 572RR UT WOS:000275851000002 PM 20207260 ER PT J AU De Jesus, VR Mei, JV Bell, CJ Hannon, WH AF De Jesus, Victor R. Mei, Joanne V. Bell, Carol J. Hannon, W. Harry TI Improving and Assuring Newborn Screening Laboratory Quality Worldwide: 30-Year Experience at the Centers for Disease Control and Prevention SO SEMINARS IN PERINATOLOGY LA English DT Review ID TANDEM MASS-SPECTROMETRY; DRIED BLOOD SPOTS; LYSOSOMAL STORAGE DISORDERS; PHENYLALANINE; PHENYLKETONURIA; SUCCINYLACETONE; ANTIBODIES; INFANTS; ASSAY C1 [De Jesus, Victor R.; Mei, Joanne V.; Bell, Carol J.; Hannon, W. Harry] Ctr Dis Control & Prevent, Newborn Screening Qual Assurance Program, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP De Jesus, VR (reprint author), Ctr Dis Control & Prevent, Newborn Screening Qual Assurance Program, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,NE Mail Stop F-19, Atlanta, GA 30341 USA. EM vdejesus@cdc.gov NR 25 TC 21 Z9 23 U1 2 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0146-0005 J9 SEMIN PERINATOL JI Semin. Perinatol. PD APR PY 2010 VL 34 IS 2 BP 125 EP 133 DI 10.1053/j.semperi.2009.12.003 PG 9 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 572RR UT WOS:000275851000004 PM 20207262 ER PT J AU Benson, JM Therrell, BL AF Benson, Jane M. Therrell, Bradford L., Jr. TI History and Current Status of Newborn Screening for Hemoglobinopathies SO SEMINARS IN PERINATOLOGY LA English DT Review DE newborn screening; hemoglobinopathies; sickle cell disease; history ID SICKLE-CELL-ANEMIA; DRIED BLOOD SPECIMENS; HEINZ-BODY ANAEMIA; ABNORMAL HEMOGLOBINS; ENZYMATIC AMPLIFICATION; BETA-THALASSEMIA; FILTER-PAPER; HBA(1C) DETERMINATION; UNSTABLE HEMOGLOBINS; ANTENATAL DIAGNOSIS C1 [Therrell, Bradford L., Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, Natl Newborn Screening & Genet Resource Ctr, Austin, TX 78757 USA. [Benson, Jane M.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Therrell, BL (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, Natl Newborn Screening & Genet Resource Ctr, 1912 W Anderson Lane 210, Austin, TX 78757 USA. EM therrell@uthscsa.edu FU HRSA [U32MC00148] FX Supported in part by HRSA grant U32MC00148. NR 129 TC 34 Z9 35 U1 2 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0146-0005 EI 1558-075X J9 SEMIN PERINATOL JI Semin. Perinatol. PD APR PY 2010 VL 34 IS 2 BP 134 EP 144 DI 10.1053/j.semperi.2009.12.006 PG 11 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 572RR UT WOS:000275851000005 PM 20207263 ER PT J AU White, KR Forsman, I Eichwald, J Munoz, K AF White, Karl R. Forsman, Irene Eichwald, John Munoz, Karen TI The Evolution of Early Hearing Detection and Intervention Programs in the United States SO SEMINARS IN PERINATOLOGY LA English DT Review DE EHDI programs; infant hearing loss; newborn hearing screening ID NEWBORN; IDENTIFICATION; INFANT; IMPAIRMENT; LANGUAGE; EXPERIENCE; CHILDREN C1 [White, Karl R.; Munoz, Karen] Utah State Univ, NCHAM, Logan, UT 84322 USA. [Forsman, Irene] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Eichwald, John] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP White, KR (reprint author), Utah State Univ, NCHAM, 2880 Old Main Hill, Logan, UT 84322 USA. EM karl.white@usu.edu FU Maternal and Child Health Bureau [U52MC043916] FX Supported in part by the Maternal and Child Health Bureau under Grant Number U52MC043916. NR 62 TC 35 Z9 39 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0146-0005 J9 SEMIN PERINATOL JI Semin. Perinatol. PD APR PY 2010 VL 34 IS 2 BP 170 EP 179 DI 10.1053/j.semperi.2009.12.009 PG 10 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 572RR UT WOS:000275851000009 PM 20207267 ER PT J AU McRee, AL Brewer, NT Reiter, PL Gottlieb, SL Smith, JS AF McRee, Annie-Laurie Brewer, Noel T. Reiter, Paul L. Gottlieb, Sami L. Smith, Jennifer S. TI The Carolina HPV Immunization Attitudes and Beliefs Scale (CHIAS): Scale Development and Associations With Intentions to Vaccinate SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID HUMAN-PAPILLOMAVIRUS VACCINATION; PLANNED BEHAVIOR; PARENTAL ACCEPTANCE; ACCEPTABILITY; PREDICTORS; CHILDREN; WOMEN; FOCUS AB Background: No standardized instruments, to our knowledge, exist to assess attitudes and beliefs about human papillomavirus (HPV) vaccination. Methods: We developed the Carolina HPV Immunization Attitudes and Beliefs Scale (CHIAS), using data collected on 783 parents who had not yet vaccinated their daughters against HPV. We conducted a principal components analysis of 16 HPV vaccine attitude and belief items, assessed the scale's psychometric properties, and used linear regression to examine the relationship of CHIAS factors and parents' vaccination intentions. Results: Analyses identified 4 CHIAS factors, all of which had acceptable scale alphas and 1-year test-retest reliability. In multivariate models, higher vaccination intentions were associated with: believing HPV vaccine is effective (beta = 0.06) or has less harmful effects (beta = -0.47), perceiving more barriers to access (beta = 0.18), and having less uncertainty about the vaccine (beta = -0.23) (all P < 0.05). Conclusions: Findings suggest that parent attitudes about HPV vaccine are important to their intentions to vaccinate their adolescent daughters against HPV. The CHIAS offers researchers a compact, standardized measure of important HPV vaccine attitudes and beliefs. C1 [McRee, Annie-Laurie; Brewer, Noel T.; Reiter, Paul L.] UNC, Dept Hlth Behav, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [McRee, Annie-Laurie; Brewer, Noel T.; Reiter, Paul L.] UNC, Dept Hlth Educ, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Smith, Jennifer S.] UNC, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Gottlieb, Sami L.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP McRee, AL (reprint author), UNC, Dept Hlth Behav & Hlth Educ, Gillings Sch Global Publ Hlth, 325B Rosenau Hall,CB 7440, Chapel Hill, NC 27599 USA. EM almcree@email.unc.edu; ntb@unc.edu RI McRee, Annie/J-3077-2013 FU Centers for Disease Control and Prevention [S3715-25/25]; American Cancer Society [MSRG-06-259-01CPPB] FX Supported by the Centers for Disease Control and Prevention (S3715-25/25) and the American Cancer Society (MSRG-06-259-01CPPB). NR 29 TC 32 Z9 32 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD APR PY 2010 VL 37 IS 4 BP 234 EP 239 DI 10.1097/OLQ.0b013e3181c37e15 PG 6 WC Infectious Diseases SC Infectious Diseases GA 579MC UT WOS:000276373700007 PM 19940807 ER PT J AU Winscott, M Taylor, MM Kenney, K AF Winscott, Michelle Taylor, Melanie M. Kenney, Kerry TI Identifying Unreported and Undiagnosed Cases of Congenital Syphilis in Arizona Using Live Birth and Fetal Death Registries SO SEXUALLY TRANSMITTED DISEASES LA English DT Article DE syphilis; congenital syphilis; prenatal care; prenatal syphilis screening; cross-match ID OPPORTUNITIES; PREVENTION AB To investigate the drop in reported congenital syphilis cases from 28 in 2005 to 16 in 2006, the Arizona infant registries were cross matched with reported syphilis test among women in th estat STD database. Six previously unreported cases were identified; four live births and two stil births. C1 [Winscott, Michelle] Arizona Dept Hlth Serv, Off Infect Dis Serv, STD Control Program, Phoenix, AZ 85007 USA. [Taylor, Melanie M.; Kenney, Kerry] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA. RP Winscott, M (reprint author), Arizona Dept Hlth Serv, Off Infect Dis Serv, STD Control Program, 150 N 18th Ave,Suite 140, Phoenix, AZ 85007 USA. EM winscom@azdhs.gov FU Centers for Disease Control and Prevention [1H25PS001385-01] FX Supported by the Cooperative Agreement Number 1H25PS001385-01 from the Centers for Disease Control and Prevention. NR 21 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD APR PY 2010 VL 37 IS 4 BP 244 EP 247 DI 10.1097/OLQ.0b013e3181c37e2a PG 4 WC Infectious Diseases SC Infectious Diseases GA 579MC UT WOS:000276373700009 PM 20023596 ER PT J AU Ling, SB Richardson, DB Mettenbrink, CJ Westergaard, BC Sapp-Jones, TD Crane, LA Nyquist, AC McFarlane, M Kachur, R Rietmeijer, CA AF Ling, Sarah B. Richardson, Douglas B. Mettenbrink, Christie J. Westergaard, Benton C. Sapp-Jones, Terri D. Crane, Lori A. Nyquist, Ann-Christine McFarlane, Mary Kachur, Rachel Rietmeijer, Cornelis A. TI Evaluating a Web-Based Test Results System at an Urban STI Clinic SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID PARTNER NOTIFICATION; COMMUNICATION; INTERNET; SATISFACTION; ATTITUDES; RECORD; CARE AB Background: Notifying patients of gonorrhea and chlamydia test results using online services may improve clinic efficiency and increase receipt of test results. This study evaluated the implementation of an online results system in an urban sexually transmitted infections clinic. Methods: Using the clinic's electronic medical records system to assess if and how gonorrhea and chlamydia test results were obtained, 3 time periods were examined between December 2007 and April 2009: Period 1, six months before initiation of the online results system; Period 2, six months when patients could opt in for online results by creating their own access codes; and Period 3, four months when access codes were assigned. In addition, a survey was conducted to assess reasons for accepting or declining the online results system. Results: A total of 9056 new patient visits were evaluated. During Periods 1, 2, and 3, respectively 67%, 67%, and 70% patients received results either online or by telephone (NS). The proportion of patients calling the clinic for results decreased from 67% in Period 1, to 51% in Period 2, and 36% in Period 3 (P < 0.0001). Survey results indicated that patients accepted online results primarily because of the ability to check results anytime of day. Reasons for not accepting results online included lack of Internet access or a preference to receive results via the telephone. Conclusions: The online results system decreased the number of phone calls to the clinic pertaining to STI test results, but had no effect on the overall proportion of patients receiving results. C1 [Ling, Sarah B.; Richardson, Douglas B.; Mettenbrink, Christie J.; Westergaard, Benton C.; Sapp-Jones, Terri D.; Rietmeijer, Cornelis A.] Denver Publ Hlth Dept, Denver, CO 80204 USA. [Ling, Sarah B.; Crane, Lori A.; Nyquist, Ann-Christine; Rietmeijer, Cornelis A.] Univ Colorado Denver, Dept Community & Behav Hlth, Colorado Sch Publ Hlth, Aurora, CO USA. [Nyquist, Ann-Christine] Childrens Hosp, Epidemiol Sect, Aurora, CO USA. [McFarlane, Mary; Kachur, Rachel] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Rietmeijer, CA (reprint author), Denver Publ Hlth Dept, Pavil H,Unit 03,605 Bannock St, Denver, CO 80204 USA. EM cornelis.rietmeijer@dhha.org FU ODCDC CDC HHS [5U50CD300860-21] NR 14 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD APR PY 2010 VL 37 IS 4 BP 259 EP 263 DI 10.1097/OLQ.0b013e3181d3d037 PG 5 WC Infectious Diseases SC Infectious Diseases GA 579MC UT WOS:000276373700012 PM 20220562 ER PT J AU Burington, B Hughes, JP Whittington, WLH Stoner, B Garnett, G Aral, SO Holmes, KK AF Burington, Bart Hughes, James P. Whittington, William L. H. Stoner, Brad Garnett, Geoff Aral, Sevgi O. Holmes, King K. TI Estimating duration in partnership studies: issues, methods and examples SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article ID SEXUAL MIXING PATTERNS; TRANSMISSION; EPIDEMIOLOGY; INFECTIONS; GONORRHEA; LENGTH; GAP AB Background and objectives Understanding the time course of sexual partnerships is important for understanding sexual behaviour, transmission risks for sexually transmitted infections (STI) and development of mathematical models of disease transmission. Study design The authors describe issues and biases relating to censoring, truncation and sampling that arise when estimating partnership duration. Recommendations for study design and analysis methods are presented and illustrated using data from a sexual-behaviour survey that enrolled individuals from an adolescent-health clinic and two STD clinics. Survey participants were queried, for each of (up to) four partnerships in the last 3 months, about the month and year of first sex, the number of days since last sex and whether partnerships were limited to single encounters. Participants were followed every 4 months for up to 1 year. Results After adjustment for censoring and truncation, the estimated median duration of sexual partnerships declined from 9 months (unadjusted) to 1.6 months (adjusted). Similarly, adjustment for censoring and truncation reduced the bias in relative risks for the effect of age in a Cox model. Other approaches, such as weighted estimation, also reduced bias in the estimated duration distribution. Conclusion Methods are available for estimating partnership duration from censored and truncated samples. Ignoring censoring, truncation and other sampling issues results in biased estimates. C1 [Burington, Bart] Genentech Inc, San Francisco, CA 94080 USA. [Hughes, James P.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Whittington, William L. H.; Holmes, King K.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Stoner, Brad] Washington Univ, Dept Anthropol, St Louis, MO 63130 USA. [Garnett, Geoff] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England. [Aral, Sevgi O.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Hughes, JP (reprint author), Univ Washington 357232, Dept Biostat, Seattle, WA 98115 USA. EM jphughes@u.washington.edu RI Garnett, Geoffrey/A-9312-2008 FU National Institutes of Health [AI31448, AI29168] FX The work was supported by National Institutes of Health grants AI31448 and AI29168. NR 17 TC 10 Z9 10 U1 1 U2 3 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD APR PY 2010 VL 86 IS 2 BP 84 EP 89 DI 10.1136/sti.2009.037960 PG 6 WC Infectious Diseases SC Infectious Diseases GA 573GL UT WOS:000275896700005 PM 20332366 ER PT J AU Parra, DC Gomez, LF Sarmiento, OL Buchner, D Brownson, R Schimd, T Gomez, V Lobelo, F AF Parra, Diana C. Gomez, Luis F. Sarmiento, Olga L. Buchner, David Brownson, Ross Schimd, Thomas Gomez, Viviola Lobelo, Felipe TI Perceived and objective neighborhood environment attributes and health related quality of life among the elderly in Bogota, Colombia SO SOCIAL SCIENCE & MEDICINE LA English DT Article DE Health related quality of life; Neighborhood environment; Walking; Older adults; Colombia; Perceived environmental indicators ID SELF-RATED HEALTH; OLDER-ADULTS; BUILT ENVIRONMENT; PHYSICAL-ACTIVITY; WALKING ACTIVITY; ALAMEDA COUNTY; QUESTIONNAIRES; POPULATION; POLICY; LEVEL AB This study examines associations between neighborhood environment attributes and health related quality of life (HRQOL) and self-rated health (SRH) among older adults (60 years and over) in Bogota, Colombia. Perceived and objective neighborhood environmental characteristics were assessed in a cross sectional multilevel design with 1966 older adults within 50 neighborhoods. Outcome variables included HRQOL (physical and mental dimensions) and SRH measured with the Spanish version of the Short Form 8 (SF-8). Independent variables included perceived and objective neighborhood characteristics as well as self-reported levels of walking. Hierarchical linear and logistic regression models were used for the analysis. Among perceived neighborhood characteristics, safety from traffic was positively associated with both HRQOL dimensions and SRH. Having safe parks was positively associated with the mental dimension of HRQOL and with SRH. Street noise was negatively associated with both HRQOL dimensions. Regarding objective neighborhood characteristics, residing in areas with more than eight percent of land covered by public parks was positively associated with SRH. Objective and perceived neighborhood characteristics could provide insight into potential interventions among older adults from rapidly urbanizing settings in Latin America. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Parra, Diana C.; Brownson, Ross] Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, St Louis, MO 63130 USA. [Parra, Diana C.; Gomez, Luis F.] Fdn FES Social, Hlth Div, Bogota, Colombia. [Gomez, Luis F.] Univ Javeriana, Sch Med, Bogota, Colombia. [Sarmiento, Olga L.] Univ Los Andes, Sch Med, Bogota, Colombia. [Buchner, David] Univ Illinois, Dept Kinesiol & Community Hlth, Champaign, IL USA. [Brownson, Ross] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA. [Brownson, Ross] Alvin J Siteman Canc Ctr, St Louis, MO USA. [Schimd, Thomas; Lobelo, Felipe] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Atlanta, GA USA. [Gomez, Viviola] Univ Los Andes, Fac Social Sci, Dept Psychol, Bogota, Colombia. RP Parra, DC (reprint author), Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, St Louis, MO 63130 USA. EM dianacpp79@yahoo.com RI lobelo, felipe/B-9148-2013; Parra, Diana/B-7761-2015; OI Parra, Diana/0000-0002-9797-6231; Sarmiento, Olga/0000-0002-9190-3568; Lobelo, Felipe/0000-0003-4185-7193 NR 46 TC 49 Z9 50 U1 8 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-9536 J9 SOC SCI MED JI Soc. Sci. Med. PD APR PY 2010 VL 70 IS 7 BP 1070 EP 1076 DI 10.1016/j.socscimed.2009.12.024 PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 581AU UT WOS:000276493400016 PM 20138418 ER PT J AU Tong, X Kuklina, EV George, MG AF Tong, Xin Kuklina, Elena V. George, Mary G. TI Medical Complications Among Ischemic Stroke Hospitalizations in the United States: 1999-2006 SO STROKE LA English DT Meeting Abstract CT International Stroke Conference CY FEB 23-26, 2010 CL San Antonio, TX SP Amer Heart Assoc, Amer Stroke Assoc C1 [Tong, Xin; Kuklina, Elena V.; George, Mary G.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD APR PY 2010 VL 41 IS 4 BP E252 EP E252 PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 575XU UT WOS:000276106100251 ER PT J AU Lee, ACY Schantz, PM Kazacos, KR Montgomery, SP Bowman, DD AF Lee, Alice C. Y. Schantz, Peter M. Kazacos, Kevin R. Montgomery, Susan P. Bowman, Dwight D. TI Epidemiologic and zoonotic aspects of ascarid infections in dogs and cats SO TRENDS IN PARASITOLOGY LA English DT Review ID TOXOCARA-CANIS; RISK-FACTORS; SAO-PAULO; SEROPREVALENCE; EGGS; CONTAMINATION; TRANSMISSION; CONSUMPTION; PARASITES; BRAZIL AB Toxocara canis and Toxocara cati of dogs and cats, respectively, can cause significant disease in people. Human seroprevalence for Toxocara antibodies varies with factors such as geographic location, socioeconomic status, and dietary habits. Risk factors for infection include geophagia and low-level education. Toxocara canis is better recognized as a cause of human toxocariasis, but Toxocara cati should not be overlooked. In addition, patent infections with Baylisascaris procyonis, the raccoon ascarid, have been increasingly recognized in dogs. Pet owners need to be properly educated about zoonotic risks, and veterinarians should institute regular parasite screening and treatment for all pets. Establishment of national surveillance programs to determine the incidence and specific etiological agent in human larva migrans patients would aid in the development of targeted intervention strategies. C1 [Lee, Alice C. Y.; Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA. [Schantz, Peter M.; Montgomery, Susan P.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Kazacos, Kevin R.] Purdue Univ, Sch Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA. RP Lee, ACY (reprint author), Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Campus Rd, Ithaca, NY 14853 USA. EM cl568@cornell.edu OI Lee, Alice/0000-0002-6506-684X NR 35 TC 66 Z9 69 U1 2 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 155 EP 161 DI 10.1016/j.pt.2010.01.002 PG 7 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200002 PM 20172762 ER PT J AU Bowman, DD Montgomery, SP Zajac, AM Eberhard, ML Kazacos, KR AF Bowman, Dwight D. Montgomery, Susan P. Zajac, Anne M. Eberhard, Mark L. Kazacos, Kevin R. TI Hookworms of dogs and cats as agents of cutaneous larva migrans SO TRENDS IN PARASITOLOGY LA English DT Review ID ANCYLOSTOMA-CANINUM; CREEPING ERUPTION; FOLLICULITIS; OUTBREAK; CEYLANICUM; INFECTION; AUSTRALIA; ENGLAND AB Dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably, cutaneous larva migrans. Ancylostoma braziliense is most often implicated in dermatological lesions, and Ancylostoma caninum has been associated with eosinophilic enteritis and suggested as a possible cause of diffuse unilateral subacute neuroretinitis in humans. Other manifestations include eosinophilic pneumonitis, localized myositis, folliculitis, erythema multiforme, or ophthalmological manifestations. Ancylostoma eggs are morphologically indistinguishable, which complicates epidemiological studies. Surveys of dermatologists, gastroenterologists, and ophthalmologists would help to define the incidence of these zoonotic infections. Improved diagnostic tests are needed to identify the causative species involved and understand the epidemiology of hookworm disease. This review describes the discovery of the disease, the biology of the agents, and how that biology may impact disease. C1 [Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14850 USA. [Montgomery, Susan P.; Eberhard, Mark L.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Zajac, Anne M.] Virginia Tech, Dept Biomed Sci & Pathobiol, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. [Kazacos, Kevin R.] Purdue Univ, Sch Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA. RP Bowman, DD (reprint author), Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Campus Rd, Ithaca, NY 14850 USA. EM ddb3@cornell.edu NR 50 TC 71 Z9 77 U1 3 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 162 EP 167 DI 10.1016/j.pt.2010.01.005 PG 6 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200003 PM 20189454 ER PT J AU Lee, ACY Montgomery, SP Theis, JH Blagburn, BL Eberhard, ML AF Lee, Alice C. Y. Montgomery, Susan P. Theis, Jerold H. Blagburn, Byron L. Eberhard, Mark L. TI Public health issues concerning the widespread distribution of canine heartworm disease SO TRENDS IN PARASITOLOGY LA English DT Review ID HUMAN PULMONARY DIROFILARIASIS; IMMITIS INFECTION; DOGS; EPIDEMIOLOGY; AMERICA; STATES; BRAZIL; NORTH AB Heartworms can cause serious cardiopulmonary disease in their canid hosts. Canine heartworm has become widespread in many parts of the world, and its range continues to expand. Wildlife reservoirs play a role in perpetuation and transmission of this parasite to dogs. Human heartworm infection is incidental and is typically not associated with severe clinical disease; however, because no serological test is readily available, patients must undergo invasive procedures to differentiate heartworm from other more serious diseases. Human cases have been reported mainly in areas of high canine prevalence, highlighting the importance of heartworm testing and chemoprophylaxis in all dogs to reduce transmission. Future efforts should focus on the development of a non-invasive diagnostic test for people, and on epidemiological surveys for both animals and people. C1 [Lee, Alice C. Y.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA. [Montgomery, Susan P.; Eberhard, Mark L.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Theis, Jerold H.] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA. [Blagburn, Byron L.] Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA. RP Lee, ACY (reprint author), Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Campus Rd, Ithaca, NY 14853 USA. EM cl568@cornell.edu OI Lee, Alice/0000-0002-6506-684X NR 36 TC 31 Z9 33 U1 1 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 168 EP 173 DI 10.1016/j.pt.2010.01.003 PG 6 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200004 PM 20181530 ER PT J AU Lucio-Forster, A Griffiths, JK Cama, VA Xiao, LH Bowman, DD AF Lucio-Forster, Araceli Griffiths, Jeffrey K. Cama, Vitaliano A. Xiao, Lihua Bowman, Dwight D. TI Minimal zoonotic risk of cryptosporidiosis from pet dogs and cats SO TRENDS IN PARASITOLOGY LA English DT Review ID VIRUS-INFECTED INDIVIDUALS; HIV-POSITIVE PATIENTS; FECAL SAMPLES; SAO-PAULO; GASTROINTESTINAL PARASITES; MOLECULAR CHARACTERIZATION; INTESTINAL PARASITES; CLINICAL-MANIFESTATIONS; DOMESTIC DOGS; SOUTH-INDIA AB The role of dogs and cats in human cryptosporidiosis has been the focus of much attention. Studies in which genotyping of Cryptospiridium oocysts in feces of dogs and cats have been successful and have demonstrated that most infections in these animals are caused by host-specific C. canis and C. fells, respectively. Most human cases of cryptosporidiosis are associated with C. hominis and C. parvum; C. canis and C. fells are responsible for only a small number of cases. Thus, molecular epidemiologic studies support the contention that the risk of zoonotic transmission of Cryptosporidium spp. from pet cats and dogs is low. Veterinarians can inform their clients of this minimal risk, but nevertheless advise them to minimize contact with pet cat and dog feces. C1 [Lucio-Forster, Araceli; Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14850 USA. [Griffiths, Jeffrey K.] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA. [Cama, Vitaliano A.; Xiao, Lihua] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Chamblee, GA 30341 USA. RP Lucio-Forster, A (reprint author), Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Campus Rd, Ithaca, NY 14850 USA. EM al33@cornell.edu RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 NR 79 TC 34 Z9 36 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 174 EP 179 DI 10.1016/j.pt.2010.01.004 PG 6 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200005 PM 20176507 ER PT J AU Ballweber, LR Xiao, LH Bowman, DD Kahn, G Cama, VA AF Ballweber, Lora R. Xiao, Lihua Bowman, Dwight D. Kahn, Geoffrey Cama, Vitaliano A. TI Giardiasis in dogs and cats: update on epidemiology and public health significance SO TRENDS IN PARASITOLOGY LA English DT Review ID INTESTINAL PARASITES; GASTROINTESTINAL PARASITES; MOLECULAR CHARACTERIZATION; ZOONOTIC TRANSMISSION; FECAL SAMPLES; SAO-PAULO; PHYLOGENETIC ANALYSIS; CRYPTOSPORIDIUM SPP.; DEHYDROGENASE GENE; DOMESTIC-ANIMALS AB Molecular data have defined seven genetic Assemblages of Giardia duodenalis, named A-G. Humans are infected with Assemblages A and B, dogs primarily with C and D, and cats with F. Assemblage A has been subclassified into subtypes A-I to A-IV: A-I has been reported in humans and animals, A-II in humans, and A-III and IV exclusively in animals. Assemblage B has broad host specificity infecting humans and animals. Recently, small numbers of dogs and cats have been reported to also carry Assemblages A-I or B. Because these genotypes are found primarily in humans, and no comprehensive studies to address zoonotic transmission of G. duodenalis are yet available, the potential role of dogs and cats cannot be conclusively excluded. C1 [Xiao, Lihua; Kahn, Geoffrey; Cama, Vitaliano A.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Chamblee, GA 30341 USA. [Ballweber, Lora R.] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Bowman, Dwight D.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA. RP Cama, VA (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, 4770 Buford Highway, Chamblee, GA 30341 USA. EM VCama@CDC.gov RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 NR 88 TC 83 Z9 84 U1 4 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 EI 1471-5007 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 180 EP 189 DI 10.1016/j.pt.2010.02.005 PG 10 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200006 PM 20202906 ER PT J AU Elmore, SA Jones, JL Conrad, PA Patton, S Lindsay, DS Dubey, JP AF Elmore, Stacey A. Jones, Jeffrey L. Conrad, Patricia A. Patton, Sharon Lindsay, David S. Dubey, J. P. TI Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention SO TRENDS IN PARASITOLOGY LA English DT Review ID UNITED-STATES; RISK-FACTORS; PARASITOLOGICAL EXAMINATIONS; MOLECULAR CHARACTERIZATION; INTESTINAL PARASITES; NEOTROPICAL FELIDAE; COASTAL CALIFORNIA; DOMESTIC CATS; FECAL SAMPLES; LIFE-CYCLE AB Toxoplasma gondii is a parasite of birds and mammals. Cats are the only definitive host and thus the only source of infective oocysts, but other mammals and birds can develop tissue cysts. Although feline infections are typically asymptomatic, infection during human pregnancy can cause severe disease in the fetus. Cat owners can reduce their pets' exposure risk by keeping all cats indoors and not feeding them raw meat. Humans usually become infected through ingestion of oocyst-contaminated soil and water, tissue cysts in undercooked meat, or congenitally. Because of their fastidious nature, the passing of non-infective oocysts, and the short duration of oocyst shedding, direct contact with cats is not thought to be a primary risk for human infection. C1 [Elmore, Stacey A.] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Coordinating Ctr Infect Dis, Chamblee, GA 30341 USA. [Conrad, Patricia A.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA. [Patton, Sharon] Univ Tennessee, Dept Comparat Med, Coll Vet Med, Knoxville, TN 37996 USA. [Lindsay, David S.] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathol, Blacksburg, VA 24061 USA. [Dubey, J. P.] ARS, Anim Parasit Dis Lab, ANRI, USDA, Beltsville, MD 20705 USA. RP Elmore, SA (reprint author), Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, 1601 Campus Delivery, Ft Collins, CO 80523 USA. EM stacey.elmore@colostate.edu RI Lindsay, David/G-8891-2016 OI Lindsay, David/0000-0002-0592-8321 NR 82 TC 135 Z9 142 U1 8 U2 57 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 190 EP 196 DI 10.1016/j.pt.2010.01.009 PG 7 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200007 PM 20202907 ER PT J AU McElroy, KM Blagburn, BL Breitschwerdt, EB Mead, PS McQuiston, JH AF McElroy, Kristina M. Blagburn, Byron L. Breitschwerdt, Edward B. Mead, Paul S. McQuiston, Jennifer H. TI Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague SO TRENDS IN PARASITOLOGY LA English DT Review ID CTENOCEPHALIDES-FELIS BOUCHE; NORTH-CENTRAL FLORIDA; SCRATCH-DISEASE; MURINE TYPHUS; UNITED-STATES; RISK-FACTORS; HENSELAE INFECTION; YERSINIA-PESTIS; TEXAS CHILDREN; SOUTH TEXAS AB Cat-scratch disease, flea-borne typhus, and plague are three flea-associated zoonoses of cats of concern in the USA. Although flea concentrations may be heaviest in coastal and temperate climates, fleas and flea-borne disease agents can occur almost anywhere in the USA. Understanding flea-borne pathogens, and the associated risks for owners and veterinarians, is important to reduce the likelihood of zoonotic infection. C1 [McElroy, Kristina M.; McQuiston, Jennifer H.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. [Blagburn, Byron L.] Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA. [Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC 27606 USA. [Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP McQuiston, JH (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, 1600 Clifton Rd,MS G-44, Atlanta, GA 30333 USA. EM jmcquiston@cdc.gov NR 69 TC 21 Z9 22 U1 3 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 197 EP 204 DI 10.1016/j.pt.2010.01.001 PG 8 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200008 PM 20185369 ER PT J AU Nicholson, WL Allen, KE McQuiston, JH Breitschwerdt, EB Little, SE AF Nicholson, William L. Allen, Kelly E. McQuiston, Jennifer H. Breitschwerdt, Edward B. Little, Susan E. TI The increasing recognition of rickettsial pathogens in dogs and people SO TRENDS IN PARASITOLOGY LA English DT Review ID MOUNTAIN-SPOTTED-FEVER; CANINE MONOCYTIC EHRLICHIOSIS; HUMAN GRANULOCYTIC ANAPLASMOSIS; WHITE-TAILED DEER; LYME-DISEASE; EXPERIMENTAL TRANSMISSION; DERMACENTOR-VARIABILIS; CHAFFEENSIS INFECTION; AMBLYOMMA-AMERICANUM; BORRELIA-BURGDORFERI AB Dogs and people are exposed to and susceptible to infection by many of the same tick-borne bacterial pathogens in the order Rickettsiales, including Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeensis, E. ewingii, Rickettsia rickettsii, R. conorii, and other spotted fever group rickettsiae. Recent findings include descriptions of novel Ehrlichia and Rickettsia species, recognition of the occurrence and clinical significance of co-infection, and increasing awareness of Rhipicephalus sanguineus-associated diseases. Newer molecular assays are available, although renewed efforts to encourage their use are needed. This review highlights the ecology and epidemiology of these diseases, and proposes avenues for future investigation. C1 [Nicholson, William L.; McQuiston, Jennifer H.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. [Allen, Kelly E.; Little, Susan E.] Oklahoma State Univ, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA. [Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Raleigh, NC 27606 USA. RP Nicholson, WL (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. EM wan6@cdc.gov NR 73 TC 88 Z9 89 U1 5 U2 42 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 205 EP 212 DI 10.1016/j.pt.2010.01.007 PG 8 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200009 PM 20207197 ER PT J AU Little, SE Heise, SR Blagburn, BL Callister, SM Mead, PS AF Little, Susan E. Heise, Stephanie R. Blagburn, Byron L. Callister, Steven M. Mead, Paul S. TI Lyme borreliosis in dogs and humans in the USA SO TRENDS IN PARASITOLOGY LA English DT Review ID LINKED-IMMUNOSORBENT-ASSAY; MOUNTAIN-SPOTTED-FEVER; IXODES-SCAPULARIS NYMPHS; BURGDORFERI SENSU-LATO; ANTIBIOTIC-TREATMENT; UNITED-STATES; CONSENSUS STATEMENT; EHRLICHIA-CANIS; DISEASE RISK; DIAGNOSIS AB Borrelia burgdorferi sensu stricto is the only established etiologic agent of Lyme borreliosis in dogs and in humans in North America. Lyme borreliosis differs in dogs and humans in terms of clinical outcome following infection, diagnostic approaches, prevention strategies and treatment recommendations. Nonetheless, serologic evidence of exposure of dogs to B. burgdorferi agrees with the geographical distribution of autochthonous transmission of the agent of Lyme borreliosis, and continued monitoring of exposure rates in dogs might allow early recognition of geographic expansion of endemic areas as well as identify hyperendemic areas where both humans and dogs are at increased risk of infection. C1 [Little, Susan E.; Heise, Stephanie R.] Oklahoma State Univ, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA. [Blagburn, Byron L.] Auburn Univ, Coll Vet Med, Auburn, AL 36849 USA. [Callister, Steven M.] Gundersen Lutheran Hlth Syst, Dept Internal Med, Infect Dis Sect, La Crosse, WI 54601 USA. [Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP Little, SE (reprint author), Oklahoma State Univ, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA. EM susan.little@okstate.edu NR 60 TC 25 Z9 27 U1 5 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD APR PY 2010 VL 26 IS 4 SI SI BP 213 EP 218 DI 10.1016/j.pt.2010.01.006 PG 6 WC Parasitology SC Parasitology GA 583WY UT WOS:000276712200010 PM 20207198 ER PT J AU Lima, HCAV Porto, EAS Marins, JRP Alves, RM Machado, RR Braga, KNL de Paiva, FB Carmo, GMI Santelli, ACFSE Sobel, J AF Alves Vieira Lima, Helena Cristina Santana Porto, Eucilene Alves Pio Marins, Jose Ricardo Alves, Rejane Maria Machado, Rosangela Rosa Laranjeira Braga, Karla Neves de Paiva, Francisca Bernardes Ikeda Carmo, Greice Madeleine Faria Silva e Santelli, Ana Carolina Sobel, Jeremy TI Outbreak of beriberi in the state of Maranhao, Brazil: revisiting the mycotoxin aetiologic hypothesis SO TROPICAL DOCTOR LA English DT Article AB Beriberi is caused by thiamine deficiency. Early 20th century epidemics in Japan were attributed to rice contaminated by citreoviridin mycotoxin. Our investigation of an outbreak of beriberi in Brazil showed an association of beriberi with the consumption of poor quality subsistence farming rice, although, unlike other investigators of this outbreak, we did not identify citreoviridin producing fungi in the implicated rice. C1 [Alves Vieira Lima, Helena Cristina; Santana Porto, Eucilene Alves; Faria Silva e Santelli, Ana Carolina; Sobel, Jeremy] Minist Hlth, Secretariat Hlth Surveillance, Brazilian Field Epidemiol Training Program, Brasilia, DF, Brazil. [Alves, Rejane Maria; Ikeda Carmo, Greice Madeleine] Foodborne & Waterborne Dis Branch, Brasilia, DF, Brazil. [Machado, Rosangela Rosa; Laranjeira Braga, Karla Neves] Lab Coordinat Branch, Brasilia, DF, Brazil. [Sobel, Jeremy] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lima, HCAV (reprint author), Ctr Pesquisa Goncalo Moniz CPqGM, Rua Waldemar Falcao 121, BR-40296710 Candeal Salvador, BA, Brazil. EM helencris2006@gmail.com NR 10 TC 10 Z9 11 U1 0 U2 3 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0049-4755 J9 TROP DOCT JI Trop. Dr. PD APR PY 2010 VL 40 IS 2 BP 95 EP 97 DI 10.1258/td.2009.090439 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 731ML UT WOS:000288111000011 PM 20305104 ER PT J AU Ombok, M Adazu, K Odhiambo, F Bayoh, N Kiriinya, R Slutsker, L Hamel, MJ Williamson, J Hightower, A Laserson, KF Feikin, DR AF Ombok, Maurice Adazu, Kubaje Odhiambo, Frank Bayoh, Nabie Kiriinya, Rose Slutsker, Laurence Hamel, Mary J. Williamson, John Hightower, Allen Laserson, Kayla F. Feikin, Daniel R. TI Geospatial distribution and determinants of child mortality in rural western Kenya 2002-2005 SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE child mortality; risk factors; geospatial positioning; demographic surveillance system ID BURKINA-FASO; RISK-FACTORS; SPATIAL-DISTRIBUTION; MALARIA ENDEMICITY; INFANT-MORTALITY; NORTHERN GHANA; BED NETS; SURVIVAL; COHORT; POPULATION AB OBJECTIVE To describe local geospatial variation and geospatial risk factors for child mortality in rural western Kenya. METHODS We calculated under-5 mortality rates (U5MR) in 217 villages in a Health and Demographic Surveillance System (HDSS) area in western Kenya from 1 May 2002 through 31 December 2005. U5MRs by village were mapped. Geographical positioning system coordinates of residences at the time of death and distances to nearby locations were calculated. Multivariable Poisson regression accounting for clustering at the compound level was used to evaluate the association of geospatial factors and mortality for infants and children aged 1-4 years. RESULTS Among 54 057 children, the overall U5MR was 56.5 per 1000 person-years and varied by village from 21 to 177 per 1000 person-years. High mortality villages occurred in clusters by location and remained in the highest mortality quintile over several years. In multivariable analysis, controlling for maternal age and education as well as household crowding, higher infant mortality was associated with living closer to streams and further from public transport roads. For children 1-4 years, living at middle elevations (1280-1332 metres), living within lower population densities areas, and living in the northern section of the HDSS were associated with higher mortality. CONCLUSIONS Childhood mortality was significantly higher in some villages. Several geospatial factors were associated with mortality, which might indicate variability in access to health care or exposure and transmission of infectious diseases. These results are useful in prioritising areas for further study and implementing directed public health interventions. C1 [Ombok, Maurice; Adazu, Kubaje; Odhiambo, Frank; Bayoh, Nabie; Kiriinya, Rose; Slutsker, Laurence; Hamel, Mary J.; Williamson, John; Hightower, Allen; Laserson, Kayla F.; Feikin, Daniel R.] CDC, KEMRI, Res & Publ Hlth Collaborat, Kisumu, Kenya. [Adazu, Kubaje; Laserson, Kayla F.] INDEPTH Network Demog Surveillance Sites, Accra, Ghana. [Slutsker, Laurence; Hamel, Mary J.; Feikin, Daniel R.] CDC, Malaria Branch, Div Parasit Dis, Natl Ctr Zoonoses Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Laserson, Kayla F.] CDC, Coordinating Off Global Hlth, Atlanta, GA 30333 USA. [Feikin, Daniel R.] Natl Ctr Preparedness Detect & Control Infect Dis, Div Emerging Infect & Surveillance Serv, Int Emerging Infect Program, Atlanta, GA USA. RP Ombok, M (reprint author), CDC, KEMRI, Res & Publ Hlth Collaborat, POB 1578, Kisumu, Kenya. EM mombok@ke.cdc.gov NR 41 TC 11 Z9 11 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD APR PY 2010 VL 15 IS 4 BP 423 EP 433 DI 10.1111/j.1365-3156.2010.02467.x PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 568NY UT WOS:000275530600006 PM 20409294 ER PT J AU Chaves, SS Groeger, J Helgenberger, L Auerbach, SB Bialek, SR Hu, DJ Drobeniuc, J AF Chaves, Sandra S. Groeger, Justina Helgenberger, Louisa Auerbach, Steven B. Bialek, Stephanie R. Hu, Dale J. Drobeniuc, Jan TI Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine SO VACCINE LA English DT Article DE Anamnestic response; Hepatitis B vaccination; Hepatitis B virus; Long term immunity ID LONG-TERM IMMUNOGENICITY; FOLLOW-UP; BIRTH; PROTECTION; ANTIBODY; CHILDREN; PERSISTENCE; IMMUNITY AB Some hepatitis B vaccine booster studies have suggested waning of vaccine-induced immunity in adolescents vaccinated starting at birth. Those studies, however, used a pediatric formulation of the hepatitis B vaccine as a booster to detect anamnestic response. We compared adolescents boosted with an adult dose of hepatitis B vaccine with those boosted with a pediatric dose. Among adolescents who had lost protective antibody levels against hepatitis B, a higher proportion had an anamnestic response when boosted with the adult dose (60.0% vs. 43.8%). Thus, higher antigen concentrations may be required to elicit an adequate immune memory response. Despite improved anamnestic response, our study still raises concerns about whether children immunized in early infancy will remain protected from hepatitis B as they age into adulthood. Published by Elsevier Ltd. C1 [Chaves, Sandra S.; Groeger, Justina; Bialek, Stephanie R.; Hu, Dale J.; Drobeniuc, Jan] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Helgenberger, Louisa] Federated States Micronesia Natl Govt, Dept Hlth & Social Affairs, Palikir, Pohnpei, Micronesia. [Auerbach, Steven B.] US Hlth Resources & Serv Adm, New York Reg Div, Off Performance Review, Rockville, MD 20857 USA. RP Chaves, SS (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd NE,MS G-37, Atlanta, GA 30333 USA. EM schaves@cdc.gov FU Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education FX We are extremely grateful to all participants and those who contributed to the implementation of this project the field study team and nurses, in particular Mr Spencer Donre, Mr Hinden Allexander and Ms Kiomy Noket, and CDC Hepatitis Reference Laboratory personnel-Ms Tracy Green-Monthfort and Mrs Ngok-Thao Le. This study could not be done without the valuable support of the Department of Health & Social Affairs, Federated States of Micronesia National Government, Palikir, Pohnpei, FSM. This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 18 TC 13 Z9 13 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 1 PY 2010 VL 28 IS 16 BP 2860 EP 2864 DI 10.1016/j.vaccine.2010.01.059 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 587EJ UT WOS:000276972100011 PM 20153793 ER PT J AU Prabhu, VS AF Prabhu, Vimalanand S. TI Tests of Intrahousehold Resource Allocation Using a CV Framework: A Comparison of Husbands' and Wives' Separate and Joint WTP in the Slums of Navi-Mumbai, India SO WORLD DEVELOPMENT LA English DT Article DE intrahousehold resource allocation; Malaria vaccine willingness to pay (WTP); behavioral aggregation; contingent valuation; India; Asia ID BARGAINED HOUSEHOLD DECISIONS; DEMAND; VACCINES; ETHIOPIA; GENDER AB Husbands and wives from 422 households in the slums of Navi-Mumbai. India, were interviewed separately first and jointly thereafter in a contingent valuation framework to assess their individual and joint household willingness to pay (WTP) for malaria vaccines. Husbands' and wives' demand differed significantly when they were interviewed separately but not when they were interviewed jointly. The author rejects the common preference model and unified (bargaining) model of intrahousehold resource allocation. Researchers should consider the complexity of intrahousehold decision making when they conduct stated preference surveys, even in patriarchal societies. (C) 2009 Elsevier Ltd. All rights reserved. RP Prabhu, VS (reprint author), Ctr Dis Control & Prevent, MS-E30,1600 Clifton Rd,NE, Atlanta, GA 30333 USA. EM prabhu@unc.edu NR 30 TC 8 Z9 8 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0305-750X J9 WORLD DEV JI World Dev. PD APR PY 2010 VL 38 IS 4 BP 606 EP 619 DI 10.1016/j.worlddev.2009.12.002 PG 14 WC Economics; Planning & Development SC Business & Economics; Public Administration GA 574MI UT WOS:000275993200013 ER PT J AU Ford, ES Zhao, GX Li, CY AF Ford, Earl S. Zhao, Guixiang Li, Chaoyang TI Pre-Diabetes and the Risk for Cardiovascular Disease A Systematic Review of the Evidence SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE cardiovascular diseases; coronary heart disease; hyperglycemia; meta-analysis; prediabetic state; review ID CORONARY-HEART-DISEASE; IMPAIRED FASTING GLUCOSE; METABOLIC SYNDROME; DIABETES-MELLITUS; FOLLOW-UP; ALL-CAUSE; POSTCHALLENGE HYPERGLYCEMIA; ATHEROSCLEROSIS RISK; BLOOD-GLUCOSE; MORTALITY AB Objectives Our objective was to estimate the magnitude of the relative risk (RR) for cardiovascular disease associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from published prospective observational studies. Background Hyperglycemia is a known risk factor for cardiovascular disease. However, the magnitude of the RR for cardiovascular disease associated with IFG and IGT is unclear. Methods We searched PubMed from 1997 through 2008 for relevant publications and performed a meta-analysis. Results In 18 publications with information about IFG (110 to 125 mg/dl) (IFG 110), estimates of RR ranged from 0.65 to 2.50. The fixed-effects summary estimate of RR was 1.20 (95% confidence interval [CI]: 1.12 to 1.28). In 8 publications with information about IFG (100 to 125 mg/dl) (IFG 100), estimates of RR ranged from 0.87 to 1.40. The fixed-effects summary estimate of RR was 1.18 (95% CI: 1.09 to 1.28). In 8 publications with information about IGT, estimates of RR ranged from 0.83 to 1.34. The fixed-effects summary estimate of RR was 1.20 (95% CI: 1.07 to 1.34). Five studies combined IFG and IGT, yielding a fixed-effects summary estimate of RR of 1.10 (95% CI: 0.99 to 1.23). No significant difference between the summary estimates for men and women were detected (IFG 110: men: 1.17 [95% CI: 1.05 to 1.31], women: 1.30 [95% CI: 1.10 to 1.54]; IFG 100: men: 1.23 [95% CI: 1.06 to 1.42], women: 1.16 [95% CI: 0.99 to 1.36]). Conclusions Impaired fasting glucose and IGT are associated with modest increases in the risk for cardiovascular disease. (J Am Coll Cardiol 2010; 55: 1310-7) (C) 2010 by the American College of Cardiology Foundation C1 [Ford, Earl S.; Zhao, Guixiang; Li, Chaoyang] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K66, Atlanta, GA 30341 USA. EM eford@cdc.gov NR 53 TC 173 Z9 185 U1 1 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 30 PY 2010 VL 55 IS 13 BP 1310 EP 1317 DI 10.1016/j.jacc.2009.10.060 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 573CL UT WOS:000275885900004 PM 20338491 ER PT J AU Sejvar, JJ Uyeki, TM AF Sejvar, James J. Uyeki, Timothy M. TI Neurologic complications of 2009 influenza A (H1N1) Heightened attention on an ongoing question SO NEUROLOGY LA English DT Editorial Material ID ENCEPHALOPATHY; ENCEPHALITIS C1 [Sejvar, James J.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. RP Sejvar, JJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA. EM zea3@cdc.gov NR 10 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR 30 PY 2010 VL 74 IS 13 BP 1020 EP 1021 DI 10.1212/WNL.0b013e3181d6b869 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 577WU UT WOS:000276255500004 PM 20200340 ER PT J AU Zhang, L Prather, D Eng, JV Crawford, S Kariuki, S ter Kuile, F Terlouw, D Nahlen, B Lal, AA Slutsker, L Udhayakumar, V Shi, YP AF Zhang, Lyna Prather, Donald Eng, Jodi Vanden Crawford, Sara Kariuki, Simon ter Kuile, Feiko Terlouw, Dianne Nahlen, Bernard Lal, Altaf A. Slutsker, Laurence Udhayakumar, Venkatachalam Shi, Ya Ping TI Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya SO MALARIA JOURNAL LA English DT Article ID BLOOD-STAGE MALARIA; LINKAGE DISEQUILIBRIUM; HUMAN GENOME; LONGITUDINAL COHORT; AFRICAN POPULATIONS; CEREBRAL MALARIA; INFECTION LEVELS; IN-VIVO; DISEASE; EPIDEMIOLOGY AB Background: Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of malarial anaemia and decreased IL12 levels are associated with severe malarial anaemia (SMA) in children. Based on the biological relevance of IL12 in malaria anaemia, the relationship between genetic polymorphisms of IL12 and its receptors and SMA was examined. Methods: Fifty-five tagging single nucleotide polymorphisms covering genes encoding two IL12 subunits, IL12A and IL12B, and its receptors, IL12RB1 and IL12RB2, were examined in a cohort of 913 children residing in Asembo Bay region of western Kenya. Results: An increasing copy number of minor variant (C) in IL12A (rs2243140) was significantly associated with a decreased risk of SMA (P = 0.006; risk ratio, 0.52 for carrying one copy of allele C and 0.28 for two copies). Individuals possessing two copies of a rare variant (C) in IL12RB1 (rs429774) also appeared to be strongly protective against SMA (P = 0.00005; risk ratio, 0.18). In addition, children homozygous for another rare allele (T) in IL12A (rs22431348) were associated with reduced risk of severe anaemia (SA) (P = 0.004; risk ratio, 0.69) and of severe anaemia with any parasitaemia (SAP) (P = 0.004; risk ratio, 0.66). In contrast, AG genotype for another variant in IL12RB1 (rs383483) was associated with susceptibility to high-density parasitaemia (HDP) (P = 0.003; risk ratio, 1.21). Conclusions: This study has shown strong associations between polymorphisms in the genes of IL12A and IL12RB1 and protection from SMA in Kenyan children, suggesting that human genetic variants of IL12 related genes may significantly contribute to the development of anaemia in malaria patients. C1 [Zhang, Lyna; Prather, Donald; Eng, Jodi Vanden; Crawford, Sara; Nahlen, Bernard; Lal, Altaf A.; Slutsker, Laurence; Udhayakumar, Venkatachalam; Shi, Ya Ping] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis,Natl Ctr Zoonot Vector Borne & En, Coordinating Ctr Infect Dis, Atlanta, GA 30341 USA. [Zhang, Lyna] Ctr Dis Control & Prevent, Off Publ Genom, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. [Kariuki, Simon] Kenya Govt Med Res Ctr, Kisumu, Kenya. [ter Kuile, Feiko; Terlouw, Dianne] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. RP Zhang, L (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis,Natl Ctr Zoonot Vector Borne & En, Coordinating Ctr Infect Dis, Atlanta, GA 30341 USA. EM chn6@cdc.gov; yps0@cdc.gov OI ter Kuile, Feiko/0000-0003-3663-5617 FU Emerging Infectious Disease; American Association of Teachers and Preventive Medicine; WHO/TDR [A30322] FX We sincerely thank all the study subjects who participated in the Asembo Bay Cohort Project and community field workers for supporting the collection of data and samples. DP was supported by the Emerging Infectious Disease Postdoctoral Fellowship. LZ was funded by the Career Development Award from American Association of Teachers and Preventive Medicine. We thank the Director, Kenya Medical Research Institute for permission to publish this paper and Dr William Dotson for editorial assistance. This study was supported by WHO/TDR Collaborative Research Grant #A30322. NR 40 TC 13 Z9 13 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 29 PY 2010 VL 9 AR 87 DI 10.1186/1475-2875-9-87 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 589IL UT WOS:000277140400001 PM 20350312 ER PT J AU Dawood, FS Hope, KG Durrheim, DN Givney, R Fry, AM Dalton, CB AF Dawood, Fatimah S. Hope, Kirsty G. Durrheim, David N. Givney, Rodney Fry, Alicia M. Dalton, Craig B. TI Estimating the Disease Burden of Pandemic (H1N1) 2009 Virus Infection in Hunter New England, Northern New South Wales, Australia, 2009 SO PLOS ONE LA English DT Article ID INFLUENZA; HOSPITALIZATIONS AB Introduction: On May 26, 2009, the first confirmed case of Pandemic (H1N1) 2009 virus (pH1N1) infection in Hunter New England (HNE), New South Wales (NSW), Australia (population 866,000) was identified. We used local surveillance data to estimate pH1N1-associated disease burden during the first wave of pH1N1 circulation in HNE. Methods: Surveillance was established during June 1-August 30, 2009, for: 1) laboratory detection of pH1N1 at HNE and NSW laboratories, 2) pH1N1 community influenza-like illness (ILI) using an internet survey of HNE residents, and 3) pH1N1-associated hospitalizations and deaths using respiratory illness International Classification of Diseases 10 codes at 35 HNE hospitals and mandatory reporting of confirmed pH1N1-associated hospitalizations and deaths to the public health service. The proportion of pH1N1 positive specimens was applied to estimates of ILI, hospitalizations, and deaths to estimate disease burden. Results: Of 34,177 specimens tested at NSW laboratories, 4,094 (12%) were pH1N1 positive. Of 1,881 specimens from patients evaluated in emergency departments and/or hospitalized, 524 (26%) were pH1N1 positive. The estimated number of persons with pH1N1-associated ILI in the HNE region was 53,383 (range 37,828-70,597) suggesting a 6.2% attack rate (range 4.4-8.2%). An estimated 509 pH1N1-associated hospitalizations (range 388-630) occurred (reported: 184), and up to 10 pH1N1-associated deaths (range 8-13) occurred (reported: 5). The estimated case hospitalization ratio was 1% and case fatality ratio was 0.02%. Discussion: The first wave of pH1N1 activity in HNE resulted in symptomatic infection in a small proportion of the population, and the number of HNE pH1N1-associated hospitalizations and deaths is likely higher than officially reported. C1 [Dawood, Fatimah S.; Fry, Alicia M.] Ctr Dis Control & Prevent CDC, Influenza Div, Atlanta, GA 30333 USA. [Hope, Kirsty G.] Univ Newcastle, Hunter New England Populat Hlth & Newcastle Inst, Wallsend, Tyne & Wear, England. [Durrheim, David N.; Dalton, Craig B.] Hunter New England Populat Hlth & Hunter Med Res, Wallsend, Tyne & Wear, England. [Givney, Rodney] John Hunter Hosp, Hunter Area Pathol Serv, Newcastle, NSW, Australia. RP Dawood, FS (reprint author), Ctr Dis Control & Prevent CDC, Influenza Div, Atlanta, GA 30333 USA. EM fdawood@cdc.gov NR 16 TC 9 Z9 9 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 25 PY 2010 VL 5 IS 3 AR e9880 DI 10.1371/journal.pone.0009880 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 574DS UT WOS:000275969500012 PM 20360868 ER PT J AU High, P Handschur, EF Eze, OS Montana, B Robertson, C Tan, C Rosen, JB Cummings, KP Doll, MK Zucker, JR Zimmerman, CM Dolinsky, T Goodell, S Valure, B Schulte, C Blog, D Rausch-Phung, E Smith, P Barskey, A Wallace, G Kutty, P McLean, H Gallagher, K Harpaz, R Armstrong, GL Lowe, L McNall, R Rota, J Rota, P Hickman, C Bellini, WJ Ogbuanu, I Apostolou, A AF High, P. Handschur, E. F. Eze, O. S. Montana, B. Robertson, C. Tan, C. Rosen, J. B. Cummings, K. P. Doll, M. K. Zucker, J. R. Zimmerman, C. M. Dolinsky, T. Goodell, S. Valure, B. Schulte, C. Blog, D. Rausch-Phung, E. Smith, P. Barskey, A. Wallace, G. Kutty, P. McLean, H. Gallagher, K. Harpaz, R. Armstrong, G. L. Lowe, L. McNall, R. Rota, J. Rota, P. Hickman, C. Bellini, W. J. Ogbuanu, I. Apostolou, A. TI Update: Mumps Outbreak-New York and New Jersey, June 2009-January 2010 (Reprinted from MMWR, vol 59, pg 125-129, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Rosen, J. B.; Cummings, K. P.; Doll, M. K.; Zucker, J. R.; Zimmerman, C. M.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schulte, C.; Blog, D.; Rausch-Phung, E.; Smith, P.] New York State Dept Hlth, Albany, NY 12237 USA. [Ogbuanu, I.; Apostolou, A.] CDC, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 24 PY 2010 VL 303 IS 12 BP 1140 EP 1142 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 573AC UT WOS:000275879600009 ER PT J AU Bamberg, W Finkner, N Guppy, D Simmerly, D Clement, E Kogut, S Schaffzin, JK Flore, A Srinivasan, A Stone, N Kallen, A Hocevar, S AF Bamberg, W. Finkner, N. Guppy, D. Simmerly, D. Clement, E. Kogut, S. Schaffzin, J. K. Flore, A. Srinivasan, A. Stone, N. Kallen, A. Hocevar, S. TI Outbreaks of 2009 Pandemic Influenza A (H1N1) Among Long-Term-Care Facility Residents-Three States, 2009 (Reprinted from MMWR, vol 59, pg 74-77, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Guppy, D.] Univ So Maine, Maine Ctr Dis Control & Prevent, Portland, ME 04103 USA. [Simmerly, D.; Clement, E.; Kogut, S.; Schaffzin, J. K.] New York State Dept Hlth, Albany, NY 12237 USA. [Hocevar, S.] CDC, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 24 PY 2010 VL 303 IS 12 BP 1142 EP 1144 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 573AC UT WOS:000275879600010 ER PT J AU Wei, CJ Boyington, JC Dai, KF Houser, KV Pearce, MB Kong, WP Yang, ZY Tumpey, TM Nabel, GJ AF Wei, Chih-Jen Boyington, Jeffrey C. Dai, Kaifan Houser, Katherine V. Pearce, Melissa B. Kong, Wing-Pui Yang, Zhi-yong Tumpey, Terrence M. Nabel, Gary J. TI Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID RECEPTOR-BINDING; ANTIGENIC STRUCTURE; H1N1 INFLUENZA; A VIRUS; HEMAGGLUTININ; RECOGNITION; EPITOPE; CHALLENGE; PANDEMICS; PROTEINS AB New strains of H1N1 influenza virus have emerged episodically over the last century to cause human pandemics, notably in 1918 and recently in 2009. Pandemic viruses typically evolve into seasonal forms that develop resistance to antibody neutralization, and cross-protection between strains separated by more than 3 years is uncommon. Here, we define the structural basis for cross-neutralization between two temporally distant pandemic influenza viruses-from 1918 and 2009. Vaccination of mice with the 1918 strain protected against subsequent lethal infection by 2009 virus. Both were resistant to antibodies directed against a seasonal influenza, A/New Caledonia/20/1999 (1999 NC), which was insensitive to antisera to the pandemic strains. Pandemic strain-neutralizing antibodies were directed against a subregion of the hemagglutinin (HA) receptor binding domain that is highly conserved between the 1918 and the 2009 viruses. In seasonal strains, this region undergoes amino acid diversification but is shielded from antibody neutralization by two highly conserved glycosylation sites absent in the pandemic strains. Pandemic HA trimers modified by glycosylation at these positions were resistant to neutralizing antibodies to wild-type HA. Yet, antisera generated against the glycosylated HA mutant neutralized it, suggesting that the focus of the immune response can be selectively changed with this modification. Collectively, these findings define critical determinants of H1N1 viral evolution and have implications for vaccine design. Immunization directed to conserved receptor binding domain subregions of pandemic viruses could potentially protect against similar future pandemic viruses, and vaccination with glycosylated 2009 pandemic virus may limit its further spread and transformation into a seasonal influenza. C1 [Wei, Chih-Jen; Boyington, Jeffrey C.; Dai, Kaifan; Kong, Wing-Pui; Yang, Zhi-yong; Nabel, Gary J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Houser, Katherine V.; Pearce, Melissa B.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Nabel, GJ (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM gnabel@nih.gov FU Intramural NIH HHS [Z99 AI999999] NR 30 TC 84 Z9 87 U1 2 U2 11 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 J9 SCI TRANSL MED JI Sci. Transl. Med. PD MAR 24 PY 2010 VL 2 IS 24 AR 24ra21 DI 10.1126/scitranslmed.3000799 PG 8 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 591MG UT WOS:000277304200004 PM 20375007 ER PT J AU Rao, SS Kong, WP Wei, CJ Van Hoeven, N Gorres, JP Nason, M Andersen, H Tumpey, TM Nabel, GJ AF Rao, Srinivas S. Kong, Wing-Pui Wei, Chih-Jen Van Hoeven, Neal Gorres, J. Patrick Nason, Martha Andersen, Hanne Tumpey, Terrence M. Nabel, Gary J. TI Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret SO PLOS ONE LA English DT Article ID CD8(+) T-CELLS; RECEPTOR SPECIFICITY; VIRUS-REPLICATION; A VACCINE; NEUTRALIZING ANTIBODIES; EXTRACELLULAR DOMAIN; PROTECTIVE IMMUNITY; LETHAL CHALLENGE; PLASMID DNA; M2 PROTEIN AB Efforts to develop a broadly protective vaccine against the highly pathogenic avian influenza A (HPAI) H5N1 virus have focused on highly conserved influenza gene products. The viral nucleoprotein (NP) and ion channel matrix protein (M2) are highly conserved among different strains and various influenza A subtypes. Here, we investigate the relative efficacy of NP and M2 compared to HA in protecting against HPAI H5N1 virus. In mice, previous studies have shown that vaccination with NP and M2 in recombinant DNA and/or adenovirus vectors or with adjuvants confers protection against lethal challenge in the absence of HA. However, we find that the protective efficacy of NP and M2 diminishes as the virulence and dose of the challenge virus are increased. To explore this question in a model relevant to human disease, ferrets were immunized with DNA/rAd5 vaccines encoding NP, M2, HA, NP+M2 or HA+NP+M2. Only HA or HA+NP+M2 vaccination conferred protection against a stringent virus challenge. Therefore, while gene-based vaccination with NP and M2 may provide moderate levels of protection against low challenge doses, it is insufficient to confer protective immunity against high challenge doses of H5N1 in ferrets. These immunogens may require combinatorial vaccination with HA, which confers protection even against very high doses of lethal viral challenge. C1 [Rao, Srinivas S.; Kong, Wing-Pui; Wei, Chih-Jen; Gorres, J. Patrick; Nabel, Gary J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Van Hoeven, Neal; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Nason, Martha] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA. [Andersen, Hanne] BIOQUAL Inc, Rockville, MD USA. RP Rao, SS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM gnabel@nih.gov FU National Institutes of Allergy; National Institutes of Health FX This work was funded by the intramural research program of the National Institutes of Allergy and Infectious Diseases of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 51 Z9 51 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 23 PY 2010 VL 5 IS 3 AR e9812 DI 10.1371/journal.pone.0009812 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 573FS UT WOS:000275894400015 PM 20352112 ER PT J AU Yu, W Liu, TB Valdez, R Gwinn, M Khoury, MJ AF Yu, Wei Liu, Tiebin Valdez, Rodolfo Gwinn, Marta Khoury, Muin J. TI Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes SO BMC MEDICAL INFORMATICS AND DECISION MAKING LA English DT Article ID RISK SCORE; TYPE-2; MELLITUS AB Background: We present a potentially useful alternative approach based on support vector machine (SVM) techniques to classify persons with and without common diseases. We illustrate the method to detect persons with diabetes and pre-diabetes in a cross-sectional representative sample of the U. S. population. Methods: We used data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES) to develop and validate SVM models for two classification schemes: Classification Scheme I (diagnosed or undiagnosed diabetes vs. pre-diabetes or no diabetes) and Classification Scheme II (undiagnosed diabetes or prediabetes vs. no diabetes). The SVM models were used to select sets of variables that would yield the best classification of individuals into these diabetes categories. Results: For Classification Scheme I, the set of diabetes-related variables with the best classification performance included family history, age, race and ethnicity, weight, height, waist circumference, body mass index (BMI), and hypertension. For Classification Scheme II, two additional variables-sex and physical activity-were included. The discriminative abilities of the SVM models for Classification Schemes I and II, according to the area under the receiver operating characteristic (ROC) curve, were 83.5% and 73.2%, respectively. The web-based tool-Diabetes Classifier was developed to demonstrate a user-friendly application that allows for individual or group assessment with a configurable, user-defined threshold. Conclusions: Support vector machine modeling is a promising classification approach for detecting persons with common diseases such as diabetes and pre-diabetes in the population. This approach should be further explored in other complex diseases using common variables. C1 [Yu, Wei; Liu, Tiebin; Valdez, Rodolfo; Gwinn, Marta; Khoury, Muin J.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. RP Yu, W (reprint author), Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Coordinating Ctr Hlth Promot, Atlanta, GA 30333 USA. EM wyu@cdc.gov NR 23 TC 42 Z9 44 U1 3 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6947 J9 BMC MED INFORM DECIS JI BMC Med. Inform. Decis. Mak. PD MAR 22 PY 2010 VL 10 AR 16 DI 10.1186/1472-6947-10-16 PG 7 WC Medical Informatics SC Medical Informatics GA 579SX UT WOS:000276395100001 PM 20307319 ER PT J AU Quiros-Alcala, L Smith, KD Weeresekera, G Odetokuns, M Barr, DB Nishioka, M Eskenazi, B Bradman, A AF Quiros-Alcala, Lesliam Smith, Kimberly D. Weeresekera, Gayanga Odetokuns, Martins Barr, Dana B. Nishioka, Marcia Eskenazi, Brenda Bradman, Asa TI Presence of organophosphorous pesticides and diakylphosphates in house dust from urban and farmworker homes and their association with urinary diakylphosphate metabolite levels SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94720 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Battelle Mem Inst, Columbus, OH 43201 USA. RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; Quiros-Alcala, Lesliam /Q-4928-2016 OI Quiros-Alcala, Lesliam /0000-0002-6600-7227 NR 0 TC 0 Z9 0 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 21 PY 2010 VL 239 MA 215-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V21DW UT WOS:000208189300162 ER PT J AU Coughlin, SS King, J AF Coughlin, Steven S. King, Jessica TI Breast and cervical cancer screening among women in metropolitan areas of the United States by county-level commuting time to work and use of public transportation, 2004 and 2006 SO BMC PUBLIC HEALTH LA English DT Article ID HEALTH INTERVIEW SURVEY; TRAVEL DISTANCE; PHYSICAL-ACTIVITY; PAP-SMEAR; MAMMOGRAPHY; SERVICES; POPULATION; FACILITIES; ACCESS; IMPACT AB Background: Commuting times and behaviors have been associated with a variety of chronic disease outcomes and health behaviors. We examined the relationships between ecologic measures of commuting time and use of public transportation in relation to breast and cervical cancer screening among women in U. S. metropolitan areas who participated in the 2004 and 2006 Behavioral Risk Factor Surveillance System (BRFSS) surveys. Methods: Self-reported county of residence was used to classify respondents as residents of metropolitan statistical areas (MSAs). Only BRFSS respondents who resided in the 39 MSAs with a population of >= 1.5 million in 2007 representing a total of 337 counties-were included in this analysis. A total of 76,453 women aged >= 40 years were included in analyses on mammography. Analyses on Pap testing were limited to women aged >= 18 years with no history of hysterectomy (n = 80,959). Area-based measures of socio-economic status (SES) were obtained by utilizing county-level information from the 2000 U. S. Census. Results: With adjustment for age, no important associations were observed between receipt of a recent mammogram and either a county-level measure of commute time or residence in an area where more residents had access to a car. Similarly, women living in counties where at least four percent of the residents used public transportation were as likely to have had a recent mammogram or Pap test compared with women in areas where less than four percent of residents used public transportation. However, women living in counties where < 2% of residents had no access to a car were somewhat more likely to have had a Pap test in the past 3 years than women in areas where >= 3% of the residents had no access to a car (87.3% versus 84.5%; p-value for test for trend < 0.01). In multivariate analysis, living in a county with a median commute time of at least 30 minutes was not significantly associated with having had a Pap test in the past 3 years (adjusted odds ratio (OR) = 1.1, 95% CI 0.9-1.2, p = .50), or with having had a mammogram in the past 2 years (adjusted OR = 0.9, 95% CI 0.9-1.1, p = .28). A weak positive association was observed between residence in a county with less use of public transportation and having had a Pap test in the past 3 years, which was of borderline significance (adjusted OR 1.2, 95% CI 1.0-1.4, p = .05). Conclusions: In large U. S. metropolitan areas, transportation issues may play a role in whether a woman obtains cancer screening along with other factors (e. g., Hispanic ethnicity, low income, and no physician visit in the past year). In this contextual analysis, a longer commute time was not associated with breast and cervical cancer screening. C1 [Coughlin, Steven S.; King, Jessica] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Coughlin, Steven S.] Dept Vet Affairs, Environm Epidemiol Serv, Washington, DC USA. RP Coughlin, SS (reprint author), Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30333 USA. EM steven.coughlin@va.gov NR 34 TC 16 Z9 16 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 19 PY 2010 VL 10 AR 146 DI 10.1186/1471-2458-10-146 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 580LX UT WOS:000276451100001 PM 20302614 ER PT J AU Bi, YY Li, YH Kong, MM Xiao, X Zhao, ZW He, XQ Ma, Q AF Bi, Yongyi Li, Yuhong Kong, Mengmeng Xiao, Xiao Zhao, Zhiwei He, Xiaoqing Ma, Qiang TI Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: Induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE Benzene; Microarray; CYP4F3; DNA-PKcs; DNA double strand break repair ID LEUKEMIA; HEMATOTOXICITY; METABOLISM AB Benzene causes hematotoxicity and leukemia in humans. To analyze benzene-caused aberrant gene expression, we examined differential gene expression by microarray analysis of peripheral mononuclear blood cells from seven workers diagnosed with benzene poisoning and seven matched controls. Twenty-two genes were found up-regulated and 18 down-regulated in benzene patients compared with controls. Here we report the characterization of two benzene-regulated genes. CYP4F3A, which encodes the leukotriene B(4) (LTB(4)) omega-hydroxylase, is important for inactivation of LTB(4) in neutrophils. CYP4F3A mRNA was found elevated in all patients; moreover, CYP4F3A mRNA and protein were induced by benzene metabolite phenol in HL-60 and K562 cells as well as ex vivo in human peripheral neutrophils. Silencing of CYP4F3A in HL-60 cells by lentiviral delivery of CYP4F3A-specific siRNA reduced cell survival to 56%, 44%, 22%, 14%, and 3% at 3, 4, 5, 6, and 7 days, respectively; the results suggest that CYP4F3A is a critical positive regulator of HL-60 proliferation. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. DNA-PKcs mRNA was found consistently increased in the patients and DNA-PKcs mRNA and protein were induced by hydroquinone in HL-60 cells. In a DSB model, hydroquinone induced the formation of gamma-H2AX foci, a marker of DSBs, in HL-60 cells. The findings indicate that hydroquinone induces DSBs and induction correlates with elevated levels of DNA-PKcs and NHEJ. Similar results were obtained in K562 cells treated with phenol. Since NHEJ is error-prone, induction of DNA-PKcs and NHEJ may contribute to mutagenesis and leukemia by benzene. To our knowledge, the study demonstrated for the first time that benzene and metabolites induce CYP4F3A and DNA-PKcs both in vivo and in vitro. Induction of the genes may play a role in the pathogenesis of benzene hematotoxicity and serve as biomarkers of benzene exposure. (C) 2009 Elsevier Ireland Ltd. All rights reserved. C1 [Bi, Yongyi; Li, Yuhong; Kong, Mengmeng; Xiao, Xiao; Zhao, Zhiwei] Wuhan Univ, Sch Publ Hlth, Wuhan 430071, Hubei, Peoples R China. [He, Xiaoqing; Ma, Qiang] NIOSH, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Bi, YY (reprint author), Wuhan Univ, Sch Publ Hlth, 185 Donghu Rd, Wuhan 430071, Hubei, Peoples R China. EM yongyib@yahoo.com.cn FU National Nature Science Foundation, China [30170796, 30571556, 30771784] FX The study was funded by Grants to YB from National Nature Science Foundation, China (30170796, 30571556, and 30771784). NR 16 TC 6 Z9 8 U1 2 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAR 19 PY 2010 VL 184 IS 1-2 SI SI BP 207 EP 211 DI 10.1016/j.cbi.2009.12.024 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 586CD UT WOS:000276877800027 PM 20036648 ER PT J AU Zhou, YB Tzeng, WP Wong, HC Ye, YM Jiang, J Chen, YY Huang, Y Suppiah, S Frey, TK Yang, JJ AF Zhou, Yubin Tzeng, Wen-Pin Wong, Hing-Cheung Ye, Yiming Jiang, Jie Chen, Yanyi Huang, Yun Suppiah, Suganthi Frey, Teryl K. Yang, Jenny J. TI Calcium-dependent Association of Calmodulin with the Rubella Virus Nonstructural Protease Domain SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID BINDING DOMAIN; ENERGY-TRANSFER; CAPSID PROTEIN; CLEAVAGE SITE; INTACT-CELLS; HIV-1 GP160; TROPONIN-C; AFFINITY; REPLICATION; SEQUENCE AB The rubella virus (RUBV) nonstructural (NS) protease domain, a Ca(2+)- and Zn(2+)-binding papain-like cysteine protease domain within the nonstructural replicase polyprotein precursor, is responsible for the self-cleavage of the precursor into two mature products, P150 and P90, that compose the replication complex that mediates viral RNA replication; the NS protease resides at the C terminus of P150. Here we report the Ca(2+)-dependent, stoichiometric association of calmodulin (CaM) with the RUBV NS protease. Co-immunoprecipitation and pull-down assays coupled with site-directed mutagenesis demonstrated that both the P150 protein and a 110-residue minidomain within NS protease interacted directly with Ca(2+)/CaM. The specific interaction was mapped to a putative CaM-binding domain. A 32-mer peptide (residues 1152-1183, denoted as RUBpep) containing the putative CaM-binding domain was used to investigate the association of RUBV NS protease with CaM or its N- and C-terminal subdomains. We found that RUBpep bound to Ca(2+)/CaM with a dissociation constant of 100-300 nM. The C-terminal subdomain of CaM preferentially bound to RUBpep with an affinity 12.5-fold stronger than the N-terminal subdomain. Fluorescence, circular dichroism and NMR spectroscopic studies revealed a "wrapping around" mode of interaction between RUBpep and Ca(2+)/CaM with substantially more helical structure in RUBpep and a global structural change in CaM upon complex formation. Using a site-directed mutagenesis approach, we further demonstrated that association of CaM with the CaM-binding domain in the RUBV NS protease was necessary for NS protease activity and infectivity. C1 [Tzeng, Wen-Pin; Suppiah, Suganthi; Frey, Teryl K.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA. [Wong, Hing-Cheung; Jiang, Jie; Chen, Yanyi; Huang, Yun; Yang, Jenny J.] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA. [Ye, Yiming] Ctr Dis Control & Prevent, Prote Lab, Biotechnol Core Facil Branch, Atlanta, GA 30333 USA. RP Frey, TK (reprint author), Georgia State Univ, Dept Biol, 50 Decatur St, Atlanta, GA 30303 USA. EM tfrey@gsu.edu; chejjy@langate.gsu.edu RI Zhou, Yubin/D-4748-2011; Chen, Yanyi/H-7096-2013; OI Zhou, Yubin/0000-0001-7962-0517; Chen, Yanyi/0000-0002-7755-0882; Huang, Yun/0000-0001-5950-9168 FU National Institutes of Health, NIAID [R01 AI21389]; National Institutes of Health [R01 GM62999, R01 GM081749] FX This work was supported, in whole or part, by National Institutes of Health Grants R01 AI21389 from NIAID (to T. K. F. and J. J. Y.) and R01 GM62999 and R01 GM081749 (to J. J. Y.). NR 54 TC 6 Z9 9 U1 0 U2 5 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 19 PY 2010 VL 285 IS 12 BP 8855 EP 8868 DI 10.1074/jbc.M109.097063 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 568VZ UT WOS:000275553700037 PM 20086014 ER PT J AU Holzbauer, SM DeVries, AS Sejvar, JJ Lees, CH Adjemian, J McQuiston, JH Medus, C Lexau, CA Harris, JR Recuenco, SE Belay, ED Howell, JF Buss, BF Hornig, M Gibbins, JD Brueck, SE Smith, KE Danila, RN Lipkin, WI Lachance, DH Dyck, PJB Lynfield, R AF Holzbauer, Stacy M. DeVries, Aaron S. Sejvar, James J. Lees, Christine H. Adjemian, Jennifer McQuiston, Jennifer H. Medus, Carlota Lexau, Catherine A. Harris, Julie R. Recuenco, Sergio E. Belay, Ermias D. Howell, James F. Buss, Bryan F. Hornig, Mady Gibbins, John D. Brueck, Scott E. Smith, Kirk E. Danila, Richard N. Lipkin, W. Ian Lachance, Daniel H. Dyck, P. James. B. Lynfield, Ruth TI Epidemiologic Investigation of Immune-Mediated Polyradiculoneuropathy among Abattoir Workers Exposed to Porcine Brain SO PLOS ONE LA English DT Article ID GUILLAIN-BARRE-SYNDROME; MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SEMPLE RABIES VACCINE; AUTOANTIBODIES; NEURITIS AB Background: In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head-table). An investigation was initiated to determine risk factors for illness. Methods and Results: Symptoms of the reported patients were unlike previously described occupational associated illnesses. A case-control study was conducted at Plant A. A case was defined as evidence of symptoms of peripheral neuropathy and compatible electrodiagnostic testing in a pork abattoir worker. Two control groups were used - randomly selected non-ill warm-room workers (n = 49), and all non-ill head-table workers (n = 56). Consenting cases and controls were interviewed and blood and throat swabs were collected. The 26 largest U. S. pork abattoirs were surveyed to identify additional cases. Fifteen cases were identified at Plant A; illness onsets occurred during May 2004 - November 2007. Median age was 32 years (range, 21-55 years). Cases were more likely than warm-room controls to have ever worked at the head-table (adjusted odds ratio [AOR], 6.6; 95% confidence interval [CI], 1.6-26.7), removed brains or removed muscle from the backs of heads (AOR, 10.3; 95% CI, 1.5-68.5), and worked within 0-10 feet of the brain removal operation (AOR, 9.9; 95% CI, 1.2-80.0). Associations remained when comparing head-table cases and head-table controls. Workers removed brains by using compressed air that liquefied brain and generated aerosolized droplets, exposing themselves and nearby workers. Eight additional cases were identified in the only two other abattoirs using this technique. The three abattoirs that used this technique have stopped brain removal, and no new cases have been reported after 24 months of follow up. Cases compared to controls had higher median interferon-gamma (IFN gamma) levels (21.7 pg/ml; vs 14.8 pg/ml, P < 0.001). Discussion: This novel polyradiculoneuropathy was associated with removing porcine brains with compressed air. An autoimmune mechanism is supported by higher levels of IFN gamma in cases than in controls consistent with other immune mediated illnesses occurring in association with neural tissue exposure. Abattoirs should not use compressed air to remove brains and should avoid procedures that aerosolize CNS tissue. This outbreak highlights the potential for respiratory or mucosal exposure to cause an immune-mediated illness in an occupational setting. C1 [Holzbauer, Stacy M.; DeVries, Aaron S.; Lees, Christine H.; Medus, Carlota; Lexau, Catherine A.; Smith, Kirk E.; Danila, Richard N.; Lynfield, Ruth] Minnesota Dept Hlth, Infect Dis Epidemiol Prevent & Control Div, St Paul, MN USA. [Holzbauer, Stacy M.; Adjemian, Jennifer; Harris, Julie R.; Buss, Bryan F.; Gibbins, John D.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Sejvar, James J.; McQuiston, Jennifer H.; Recuenco, Sergio E.; Belay, Ermias D.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Howell, James F.] Indiana State Dept Hlth, Indianapolis, IN 46202 USA. [Buss, Bryan F.] Nebraska Dept Hlth & Human Serv, Div Publ Hlth, Lincoln, NE USA. [Hornig, Mady; Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [Gibbins, John D.; Brueck, Scott E.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Lachance, Daniel H.; Dyck, P. James. B.] Mayo Clin, Dept Neurol, Rochester, MN USA. RP Holzbauer, SM (reprint author), Minnesota Dept Hlth, Infect Dis Epidemiol Prevent & Control Div, St Paul, MN USA. EM Aaron.DeVries@state.mn.us RI Belay, Ermias/A-8829-2013; OI Recuenco-Cabrera, Sergio/0000-0002-8446-7411 FU National Institutes of Health [U54AI5758]; Emerging Infections Program [5U01CI000313] FX Laboratory work performed by W. I. Lipkin and M. Hornig at the Columbia University Northeast Biodefense Center was funded by the National Institutes of Health award U54AI5758. Epidemiologic investigation was supported by the Emerging Infections Program Grant CFDA Number 93-283 Grant # 5U01CI000313. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 23 TC 8 Z9 9 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 19 PY 2010 VL 5 IS 3 AR e9782 DI 10.1371/journal.pone.0009782 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 572EH UT WOS:000275809700017 PM 20333310 ER PT J AU Gurley, ES Rahman, M Hossain, MJ Nahar, N Faiz, MA Islam, N Sultana, R Khatun, S Uddin, MZ Haider, MS Islam, MS Ahmed, BN Rahman, MW Mondal, UK Luby, SP AF Gurley, Emily S. Rahman, Mahmudur Hossain, M. Jahangir Nahar, Nazmun Faiz, M. Abul Islam, Nazrul Sultana, Rebeca Khatun, Selina Uddin, Mohammad Zashim Haider, M. Sabbir Islam, M. Saiful Ahmed, Be-Nazir Rahman, Muhammad Waliur Mondal, Utpal Kumar Luby, Stephen P. TI Fatal Outbreak from Consuming Xanthium strumarium Seedlings during Time of Food Scarcity in Northeastern Bangladesh SO PLOS ONE LA English DT Article ID WESTERN UTTAR-PRADESH; COCKLEBUR; CHILDREN; REDEFINITION; INTOXICATION; PRINCIPLE AB Background: An outbreak characterized by vomiting and rapid progression to unconsciousness and death was reported in Sylhet Distrct in northeastern Bangladesh following destructive monsoon floods in November 2007. Methods and Findings: We identified cases presenting to local hospitals and described their clinical signs and symptoms. We interviewed patients and their families to collect illness histories and generate hypotheses about exposures associated with disease. An epidemiological study was conducted in two outbreak villages to investigate risk factors for developing illness. 76 patients were identified from 9 villages; 25% (19/76) died. Common presenting symptoms included vomiting, elevated liver enzymes, and altered mental status. In-depth interviews with 33 cases revealed that 31 (94%) had consumed ghagra shak, an uncultivated plant, in the hours before illness onset. Ghagra shak was consumed as a main meal by villagers due to inaccessibility of other foods following destructive monsoon flooding and rises in global food prices. Persons who ate this plant were 34.2 times more likely (95% CI 10.2 to 115.8, p-value<0.000) than others to develop vomiting and unconsciousness during the outbreak in our multivariate model. Ghagra shak is the local name for Xanthium strumarium, or common cocklebur. Conclusions: The consumption of Xanthium strumarium seedlings in large quantities, due to inaccessibility of other foods, caused this outbreak. The toxic chemical in the plant, carboxyatratyloside, has been previously described and eating X. strumarium seeds and seedlings has been associated with fatalities in humans and livestock. Unless people are able to meet their nutritional requirements with safe foods, they will continue to be at risk for poor health outcomes beyond undernutrition. C1 [Gurley, Emily S.; Hossain, M. Jahangir; Nahar, Nazmun; Sultana, Rebeca; Islam, M. Saiful; Rahman, Muhammad Waliur; Mondal, Utpal Kumar; Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Programme Infect Dis & Vaccine Sci, Dhaka 1000, Bangladesh. [Rahman, Mahmudur; Khatun, Selina; Haider, M. Sabbir; Ahmed, Be-Nazir] Govt Bangladesh, Minist Hlth & Family Welf, IEDCR, Dhaka, Bangladesh. [Faiz, M. Abul] Govt Bangladesh, Minist Hlth & Family Welf, Directorate Gen Hlth Serv, Dhaka, Bangladesh. [Islam, Nazrul] Bangabandhu Sheikh Mujib Med Univ, Dept Virol, Dhaka, Bangladesh. [Uddin, Mohammad Zashim] Univ Dhaka, Dept Bot, Dhaka 1000, Bangladesh. [Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Gurley, ES (reprint author), Int Ctr Diarrhoeal Dis Res, Programme Infect Dis & Vaccine Sci, GPO Box 128, Dhaka 1000, Bangladesh. EM egurley@icddrb.org RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 FU Centers for Disease Control and Prevention, USA (CDC) [U01 CI000298]; Government of the People's Republic of Bangladesh (GoB) FX This research was funded by the Centers for Disease Control and Prevention, USA (CDC), cooperative agreement U01 CI000298, and by the Government of the People's Republic of Bangladesh (GoB). ICDDR, B acknowledges with gratitude the commitment of CDC and the GoB to the authors' research efforts. Co-authors on this paper include representatives from both the Centers for Disease Control and Prevention and the GoB, the two organizations who provided financial support for this work. These co-authors, and therefore CDC and the Government of Bangladesh, were both involved in hypothesis generation, study design, data interpretation, and review of the manuscript for publication. NR 14 TC 9 Z9 13 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 18 PY 2010 VL 5 IS 3 AR e9756 DI 10.1371/journal.pone.0009756 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 580NO UT WOS:000276456300007 PM 20305785 ER PT J AU Land, T Warner, D Paskowsky, M Cammaerts, A Wetherell, L Kaufmann, R Zhang, L Malarcher, A Pechacek, T Keithly, L AF Land, Thomas Warner, Donna Paskowsky, Mark Cammaerts, Ayesha Wetherell, LeAnn Kaufmann, Rachel Zhang, Lei Malarcher, Ann Pechacek, Terry Keithly, Lois TI Medicaid Coverage for Tobacco Dependence Treatments in Massachusetts and Associated Decreases in Smoking Prevalence SO PLOS ONE LA English DT Article AB Background: Approximately 50% of smokers die prematurely from tobacco-related diseases. In July 2006, the Massachusetts health care reform law mandated tobacco cessation coverage for the Massachusetts Medicaid population. The new benefit included behavioral counseling and all medications approved for tobacco cessation treatment by the U. S. Food and Drug Administration (FDA). Between July 1, 2006 and December 31, 2008, a total of 70,140 unique Massachusetts Medicaid subscribers used the newly available benefit, which is approximately 37% of all Massachusetts Medicaid smokers. Given the high utilization rate, the objective of this study is to determine if smoking prevalence decreased significantly after the initiation of tobacco cessation coverage. Methods and Findings: Smoking prevalence was evaluated pre- to post-benefit using 1999 through 2008 data from the Massachusetts Behavioral Risk Factor Survey (BRFSS). The crude smoking rate decreased from 38.3% (95% C. I. 33.6%-42.9%) in the pre-benefit period compared to 28.3% (95% C. I.: 24.0%-32.7%) in the post-benefit period, representing a decline of 26 percent. A demographically adjusted smoking rate showed a similar decrease in the post-benefit period. Trend analyses reflected prevalence decreases that accrued over time. Specifically, a joinpoint analysis of smoking prevalence among Massachusetts Medicaid benefit-eligible members (age 18-64) from 1999 through 2008 found a decreasing trend that was coincident with the implementation of the benefit. Finally, a logistic regression that controlled for demographic factors also showed that the trend in smoking decreased significantly from July 1, 2006 to December 31, 2008. Conclusion: These findings suggest that a tobacco cessation benefit that includes coverage for medications and behavioral treatments, has few barriers to access, and involves broad promotion can significantly reduce smoking prevalence. C1 [Land, Thomas; Warner, Donna; Paskowsky, Mark; Keithly, Lois] Massachusetts Tobacco Control Program, Boston, MA USA. [Cammaerts, Ayesha; Wetherell, LeAnn] Off Medicaid Commonwealth Massachusetts, Boston, MA USA. [Kaufmann, Rachel; Zhang, Lei; Malarcher, Ann; Pechacek, Terry] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Land, T (reprint author), Massachusetts Tobacco Control Program, Boston, MA USA. EM Thomas.Land@state.ma.us FU U.S. Centers for Disease Control and Prevention (CDC) [U58/CCU122821] FX The U.S. Centers for Disease Control and Prevention (CDC) has supported this work under the CDC Grant/Cooperative Agreement Number: U58/CCU122821. The study design, data collection instruments, data analysis, decision to publish, and preparation of the manuscript was a collaborative effort between the CDC, the Massachusetts Tobacco Control Program, and the Massachusetts Office of Medicaid. NR 12 TC 50 Z9 54 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 18 PY 2010 VL 5 IS 3 AR e9770 DI 10.1371/journal.pone.0009770 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 580NO UT WOS:000276456300010 PM 20305787 ER PT J AU de Fijter, S DiOrio, M Carmean, J Schaffzin, J Quinn, M Musser, K Nazarian, E Moore, M Beall, B Gertz, R Kallen, A Kim, C Duffy, J AF de Fijter, S. DiOrio, M. Carmean, J. Schaffzin, J. Quinn, M. Musser, K. Nazarian, E. Moore, M. Beall, B. Gertz, R., Jr. Kallen, A. Kim, C. Duffy, J. TI Bacterial Meningitis After Intrapartum Spinal Anesthesia-New York and Ohio, 2008-2009 (Reprinted from MMWR, vol 59, pg 65-69, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [de Fijter, S.; DiOrio, M.; Carmean, J.] Ohio Dept Hlth, Columbus, OH 43266 USA. [Schaffzin, J.; Quinn, M.; Musser, K.; Nazarian, E.] New York State Dept Hlth, Albany, NY 12237 USA. [Kim, C.; Duffy, J.] CDC, Atlanta, GA 30333 USA. RP de Fijter, S (reprint author), Ohio Dept Hlth, Columbus, OH 43266 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 17 PY 2010 VL 303 IS 11 BP 1026 EP 1028 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 569KC UT WOS:000275594100005 ER PT J AU Saraiya, M Benard, V Miller, J AF Saraiya, Mona Benard, Vicki Miller, Jacqueline TI Liquid-Based Cytology vs Conventional Cytology in Detecting Cervical Cancer SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 [Saraiya, Mona; Benard, Vicki; Miller, Jacqueline] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30333 USA. RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30333 USA. EM msaraiya@cdc.gov NR 4 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 17 PY 2010 VL 303 IS 11 BP 1034 EP 1034 DI 10.1001/jama.2010.277 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 569KC UT WOS:000275594100011 PM 20233819 ER PT J AU Grijalva, CG Nuorti, JP Zhu, YW Griffin, MR AF Grijalva, Carlos G. Nuorti, J. Pekka Zhu, Yuwei Griffin, Marie R. TI Increasing Incidence of Empyema Complicating Childhood Community-Acquired Pneumonia in the United States SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PNEUMOCOCCAL CONJUGATE VACCINE; PEDIATRIC PARAPNEUMONIC EMPYEMA; PLACEBO-CONTROLLED-TRIAL; STREPTOCOCCUS-PNEUMONIAE; PLEURAL FLUIDS; DOUBLE-BLIND; CHILDREN; EPIDEMIOLOGY; EFFICACY; DISEASE AB Background. The incidence of childhood pneumonia decreased following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in the United States. Recent regional reports suggest an increase in the incidence of childhood pneumonia complicated by empyema. We assessed whether early decreases in pneumonia hospitalization rates were sustained and trends in such hospitalizations complicated by empyema in United States children aged <5 years. Methods. Nationwide Inpatient Sample and Census data were used to calculate annual all-cause and pneumococcal pneumonia hospitalization rates for pre-PCV7 (1996-1999) and post-PCV7 years (2001-2007) and to analyze national trends in total and pathogen-specific pneumonia-associated empyema. Results. Among children aged <2 years, all-cause pneumonia hospitalizations decreased 33% (95% confidence interval, 28%-37%) from 1267 cases per 100,000 children in pre-PCV7 years to 852 cases per 100,000 children in post-PCV7 years. Pneumococcal pneumonia hospitalization rates decreased 61% (95% confidence interval, 55%-67%) post-PCV7, compared with pre-PCV7 years. Pneumonia hospitalizations complicated by empyema increased 2.01-fold from 3.5 cases per 100,000 children in 1996-1998 to 7.0 cases per 100,000 children in 2005-2007. Rates of pneumococcal and streptococcal empyema remained stable, whereas rates of staphylococcal and other or unspecified empyema increased 4.08- and 1.89-fold, respectively. Among children aged 2-4 years, all-cause pneumonia rates remained stable, whereas pneumococcal pneumonia decreased by 26% (95% confidence interval, 16-34). Pneumonia complicated by empyema increased 2.81-fold from 3.7 cases per 100,000 children in 1996-1998 to 10.3 cases per 100,000 children in 2005-2007. In this age group, there were 2.17-, 2.80-, 3.76-, and 3.09-fold increases in rates of pneumococcal, streptococcal, staphylococcal, and other or unspecified empyema, respectively. Conclusion. Decreases in childhood pneumonia hospitalization rates following PCV7 introduction were sustained. Although empyema complicated only a small fraction of pneumonia hospitalizations, its prevalence increased substantially. This increase was due to several pathogens and warrants continuing monitoring. C1 [Grijalva, Carlos G.; Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA. [Zhu, Yuwei] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37212 USA. [Nuorti, J. Pekka] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Grijalva, CG (reprint author), Vanderbilt Univ, Sch Med, Dept Prevent Med, 1500 21st Ave,Suite 2600, Nashville, TN 37212 USA. EM carlos.grijalva@vanderbilt.edu FU Association for Prevention Teaching and Research [TS-1454]; CDC career development award [K01 CI000163] FX CDC through a Cooperative Agreement with the Association for Prevention Teaching and Research (TS-1454); CDC career development award (K01 CI000163 to C. G. G.). NR 39 TC 89 Z9 90 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2010 VL 50 IS 6 BP 805 EP 813 DI 10.1086/650573 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 557FW UT WOS:000274656000002 PM 20166818 ER PT J AU Stern, EJ Galloway, R Shadomy, SV Wannemuehler, K Atrubin, D Blackmore, C Wofford, T Wilkins, PP Ari, MD Harris, L Clark, TA AF Stern, Eric J. Galloway, Renee Shadomy, Sean V. Wannemuehler, Kathleen Atrubin, David Blackmore, Carina Wofford, Taylor Wilkins, Patricia P. Ari, Mary D. Harris, Lazenia Clark, Thomas A. TI Outbreak of Leptospirosis among Adventure Race Participants in Florida, 2005 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CHANGING EPIDEMIOLOGY; WATERBORNE OUTBREAK; DOXYCYCLINE; CHEMOPROPHYLAXIS; PROPHYLAXIS; NOGUCHII; BRAZIL; TRIAL; JAPAN AB Background. On 21 November 2005, a 32-year-old male resident of New York was hospitalized with suspected leptospirosis. He had participated in an endurance-length swamp race on 4-5 November 2005 outside of Tampa, Florida. Methods. We interviewed racers to assess illness, medical care, and race activities. A suspected case was defined as fever plus >= 2 signs or symptoms of leptospirosis occurring in a racer after 4 November 2005. Individuals with suspected cases were referred for treatment as needed and were asked to submit serum samples for microscopic agglutination testing (MAT) and for rapid testing by the dot enzyme-linked immunosorbent assay dipstick immunoglobulin M immunoassay. Results. The Centers for Disease Control and Prevention and participating state health departments interviewed 192 (96%) of 200 racers from 32 states and Canada. Forty-four (23%) of 192 racers met the definition for a suspected case. The median age of the patients was 37 years (range, 19-66 years), and 128 (66.7%) were male. Fourteen (45%) of the 31 patients with suspected cases who were tested had their cases confirmed by serological testing (a single sample with MAT titer >= 400), including the index case patient. Organisms of a potential novel serovar (species Leptospira noguchii) were isolated in culture from 1 case patient. Factors associated with increased risk of leptospirosis included swallowing river water (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.6-7.0), swallowing swamp water (OR, 2.4; 95% CI, 1.1-5.2), and being submerged in any water (OR, 2.3; 95% CI, 1.14.7). Conclusions. This report describes a leptospirosis outbreak that resulted in a high rate of symptomatic infection among adventure racers in Florida. The growing popularity of adventure sports may put more people at risk for leptospirosis, even in areas that have not previously been considered areas of leptospirosis endemicity. C1 [Stern, Eric J.; Clark, Thomas A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Stern, Eric J.; Wofford, Taylor] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Off Workforce & Career Dev, Atlanta, GA USA. [Galloway, Renee; Shadomy, Sean V.; Wannemuehler, Kathleen; Wilkins, Patricia P.; Ari, Mary D.; Harris, Lazenia] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Atrubin, David] Hillsborough Cty Dept Hlth, Tampa, FL USA. [Blackmore, Carina] Florida Dept Hlth, Tallahassee, FL USA. RP Stern, EJ (reprint author), Georgetown Univ Hosp, Dept Pediat, Div Infect Dis, 3800 Reservoir Rd,NW 2-PHC, Washington, DC 20007 USA. EM Eric.j.stern@gunet.georgetown.edu NR 33 TC 30 Z9 32 U1 1 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2010 VL 50 IS 6 BP 843 EP 849 DI 10.1086/650578 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 557FW UT WOS:000274656000008 PM 20146629 ER PT J AU Majowicz, SE Musto, J Scallan, E Angulo, FJ Kirk, M O'Brien, SJ Jones, TF Fazil, A Hoekstra, RM AF Majowicz, Shannon E. Musto, Jennie Scallan, Elaine Angulo, Frederick J. Kirk, Martyn O'Brien, Sarah J. Jones, Timothy F. Fazil, Aamir Hoekstra, Robert M. CA Int Collaboration Enteric Dis Burd TI The Global Burden of Nontyphoidal Salmonella Gastroenteritis SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID FOODBORNE DISEASE; UNITED-STATES; DIARRHEAL DISEASE; INFECTIONS; COMMUNITY; SURVEILLANCE; PATHOGENS; AUSTRALIA; ILLNESS; CAMPYLOBACTER AB To estimate the global burden of nontyphoidal Salmonella gastroenteritis, we synthesized existing data from laboratory-based surveillance and special studies, with a hierarchical preference to (1) prospective population-based studies, (2) "multiplier studies," (3) disease notifications, (4) returning traveler data, and (5) extrapolation. We applied incidence estimates to population projections for the 21 Global Burden of Disease regions to calculate regional numbers of cases, which were summed to provide a global number of cases. Uncertainty calculations were performed using Monte Carlo simulation. We estimated that 93.8 million cases (5th to 95th percentile, 61.8-131.6 million) of gastroenteritis due to Salmonella species occur globally each year, with 155,000 deaths (5th to 95th percentile, 39,000-303,000 deaths). Of these, we estimated 80.3 million cases were foodborne. Salmonella infection represents a considerable burden in both developing and developed countries. Efforts to reduce transmission of salmonellae by food and other routes must be implemented on a global scale. C1 [Majowicz, Shannon E.] Publ Hlth Agcy Canada, Ctr Food Borne Environm & Zoonot Infect Dis, Guelph, ON, Canada. [Fazil, Aamir] Publ Hlth Agcy Canada, Lab Food Borne Zoonoses, Guelph, ON, Canada. [Musto, Jennie] New S Wales Dept Hlth, Communicable Dis Branch, Canberra, ACT, Australia. [Kirk, Martyn] Dept Hlth & Ageing, Canberra, ACT, Australia. [Kirk, Martyn] Australian Natl Univ, Canberra, ACT, Australia. [Scallan, Elaine; Angulo, Frederick J.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. [Hoekstra, Robert M.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. [Jones, Timothy F.] Tennessee Dept Hlth, Nashville, TN USA. [O'Brien, Sarah J.] Univ Manchester, Sch Translat Med, Manchester, Lancs, England. RP Musto, J (reprint author), NSW Hlth, Communicable Dis Branch, LMB 961, Sydney, NSW 2059, Australia. EM jennie.musto@gmail.com NR 29 TC 518 Z9 543 U1 15 U2 75 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2010 VL 50 IS 6 BP 882 EP 889 DI 10.1086/650733 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 557FW UT WOS:000274656000014 PM 20158401 ER PT J AU Morgan, OW Bramley, A Fowlkes, A Freedman, DS Taylor, TH Gargiullo, P Belay, B Jain, S Cox, C Kamimoto, L Fiore, A Finelli, L Olsen, SJ Fry, AM AF Morgan, Oliver W. Bramley, Anna Fowlkes, Ashley Freedman, David S. Taylor, Thomas H. Gargiullo, Paul Belay, Brook Jain, Seema Cox, Chad Kamimoto, Laurie Fiore, Anthony Finelli, Lyn Olsen, Sonja J. Fry, Alicia M. TI Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease SO PLOS ONE LA English DT Article ID A H1N1 VIRUS; UNITED-STATES; OVERWEIGHT; INFECTION; PREVALENCE; MORTALITY; HUMANS AB Background: Severe illness due to 2009 pandemic A(H1N1) infection has been reported among persons who are obese or morbidly obese. We assessed whether obesity is a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1), independent of chronic medical conditions considered by the Advisory Committee on Immunization Practices (ACIP) to increase the risk of influenza-related complications. Methodology/Principal Findings: We used a case-cohort design to compare cases of hospitalizations and deaths from 2009 pandemic A(H1N1) influenza occurring between April-July, 2009, with a cohort of the U. S. population estimated from the 2003-2006 National Health and Nutrition Examination Survey (NHANES); pregnant women and children < 2 years old were excluded. For hospitalizations, we defined categories of relative weight by body mass index (BMI, kg/m(2)); for deaths, obesity or morbid obesity was recorded on medical charts, and death certificates. Odds ratio (OR) of being in each BMI category was determined; normal weight was the reference category. Overall, 361 hospitalizations and 233 deaths included information to determine BMI category and presence of ACIP-recognized medical conditions. Among >= 20 year olds, hospitalization was associated with being morbidly obese (BMI >= 40) for individuals with ACIP-recognized chronic conditions (OR = 4.9, 95% Cl 2.4-9.9) and without ACIP-recognized chronic conditions (OR = 4.7, 95% Cl 1.3-17.2). Among 2-19 year olds, hospitalization was associated with being underweight (BMI <= 5(th) percentile) among those with (OR = 12.5, 95% Cl 3.4-45.5) and without (OR = 5.5, 95% Cl 1.3-22.5) ACIP-recognized chronic conditions. Death was not associated with BMI category among individuals 2-19 years old. Among individuals aged >= 20 years without ACIP-recognized chronic medical conditions death was associated with obesity (OR = 3.1, 95% Cl: 1.5-6.6) and morbid obesity (OR = 7.6, 95% Cl 2.1-27.9). Conclusions/Significance: Our findings support observations that morbid obesity may be associated with hospitalization and possibly death due to 2009 pandemic H1N1 infection. These complications could be prevented by early antiviral therapy and vaccination. C1 [Morgan, Oliver W.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Div Emerging Infect, Atlanta, GA 30333 USA. [Morgan, Oliver W.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Surveillance Serv, Atlanta, GA USA. [Bramley, Anna; Fowlkes, Ashley; Gargiullo, Paul; Jain, Seema; Cox, Chad; Kamimoto, Laurie; Fiore, Anthony; Finelli, Lyn; Fry, Alicia M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Freedman, David S.; Belay, Brook] Ctr Dis Control & Prevent, Div Nutr & Phys Activ & Obes, Atlanta, GA USA. [Taylor, Thomas H.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA. RP Morgan, OW (reprint author), Ctr Dis Control & Prevent, Div Emerging Infect, Atlanta, GA 30333 USA. EM afry@cdc.gov NR 26 TC 130 Z9 137 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 15 PY 2010 VL 5 IS 3 AR e9694 DI 10.1371/journal.pone.0009694 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 569SM UT WOS:000275621000012 PM 20300571 ER PT J AU McLean, CA de Wijgert, JHHMV Jones, HE Karon, JM McNicoll, JM Whitehead, SJ Braunstein, S Achalapong, J Chaikummao, S Tappero, JW Markowitz, LE Kilmarx, PH AF McLean, Catherine A. de Wijgert, Janneke H. H. M. van Jones, Heidi E. Karon, John M. McNicoll, Janet M. Whitehead, Sara J. Braunstein, Sarah Achalapong, Jullapong Chaikummao, Supaporn Tappero, Jordan W. Markowitz, Lauri E. Kilmarx, Peter H. TI HIV genital shedding and safety of Carraguard use by HIV-infected women: a crossover trial in Thailand SO AIDS LA English DT Article ID PLACEBO-CONTROLLED TRIAL; TOPICAL MICROBICIDES; SOUTH-AFRICA; VAGINAL GEL; ACCEPTABILITY; PREVENTION; EFFICACY; MICE AB Objective: To evaluate the safety, including impact on genital HIV RNA shedding, of Carraguard vaginal gel in HIV-infected women. Design: This is a randomized, controlled, crossover study of Carraguard in HIV-infected women in Thailand. Methods: Each woman (CD4(+) cell count 51-500 cells/mu l and not on antiretroviral therapy) used each treatment (Carraguard, methylcellulose placebo, and no-product) once daily for 7 days during each 1-month period (3-week wash-out). Women were randomized to one of the six possible treatment sequences. Safety assessments were conducted at baseline (pregel), 15 min postgel, day 7, and day 14, and included HIV RNA measurements in cervicovaginal lavage (CVL) specimens. Results: Sixty women were enrolled, and 99% of scheduled study visits were completed. At baseline, median age (34 years), CD4(+) lymphocyte count (296 cells/ml), plasma HIV viral load (4.6 log(10) copies/ml), CVL HIV viral load (3.1 log(10) total copies per CVL), and sexual behaviors were similar among randomization groups. HIV viral load, leukocyte and hemoglobin levels, and epithelial cell counts in CVLs were lower 15 min after application of Carraguard or placebo compared with no product; CVL HIV viral load was still lower at day 7 but returned to baseline by day 14. Carraguard use was not associated with prevalent or incident genital findings or abnormal vaginal flora. Conclusion: Carraguard appears to be well tolerated for once-daily vaginal use by HIV-infected women. The observed reduction in CVL HIV viral load in the gel months may be clinically relevant but could have resulted from interference with sample collection by study gels. (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins C1 [McLean, Catherine A.; McNicoll, Janet M.; Whitehead, Sara J.; Tappero, Jordan W.; Markowitz, Lauri E.; Kilmarx, Peter H.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30030 USA. [de Wijgert, Janneke H. H. M. van; Jones, Heidi E.; Braunstein, Sarah] Populat Council, New York, NY 10021 USA. [de Wijgert, Janneke H. H. M. van] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Jones, Heidi E.; Braunstein, Sarah] Columbia Univ, Med Ctr, New York, NY USA. [Karon, John M.] Emergint Corp, Louisville, KY USA. [McNicoll, Janet M.; Whitehead, Sara J.; Chaikummao, Supaporn; Tappero, Jordan W.] Thailand Minist Publ Hlth US CDC Collaborat, Bangkok, Thailand. [Achalapong, Jullapong] Chiang Rai Hosp, Chiang Rai, Thailand. RP Kilmarx, PH (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,MS E-45, Atlanta, GA 30030 USA. EM pbk4@cdc.gov OI Kilmarx, Peter/0000-0001-6464-3345; Jones, Heidi/0000-0002-4285-3752 FU US CDC; Bill and Melinda Gates Foundation FX The authors would like to thank the study participants for their contribution of time, energy, and commitment to this effort. The authors would also like to colleagues who contributed to study implementation: the clinical study team at the Chiang Rai Health Club, Tepnaruemit Medtanavyn, Barbara Friedland, Robin Maguire, Clyde Hart, Tammy Evans-Strickfaden, Liesbeth Bollen, Philip Mock, Chalinthorn Sinthuwattanawibool, Nancy Young, Wanna Leelawiwat, Punneporn Wasinrapee, Beth Bell, Elizabeth Unger, and Catherine Ley. The authors thank Maya Sternberg for assistance with study design and statistical support. The financial support for this study was provided by the US CDC and the Bill and Melinda Gates Foundation. NR 15 TC 12 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD MAR 13 PY 2010 VL 24 IS 5 BP 717 EP 722 DI 10.1097/QAD.0b013e328333bf89 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 563QQ UT WOS:000275148900011 PM 20098295 ER PT J AU Maltezou, HC Andonova, L Andraghetti, R Bouloy, M Ergonul, O Jongejan, F Kalvatchev, N Nichol, S Niedrig, M Platonov, A Thomson, G Leitmeyer, K Zeller, H AF Maltezou, H. C. Andonova, L. Andraghetti, R. Bouloy, M. Ergonul, O. Jongejan, F. Kalvatchev, N. Nichol, S. Niedrig, M. Platonov, A. Thomson, G. Leitmeyer, K. Zeller, H. TI Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness SO EUROSURVEILLANCE LA English DT Article ID RIBAVIRIN; VIRUS AB During the last decade Crimean-Congo hemorrhagic fever (CCHF) emerged and/or re-emerged in several Balkan countries, Turkey, southwestern regions of the Russian Federation, and the Ukraine, with considerable high fatality rates. Reasons for re-emergence of CCHF include climate and anthropogenic factors such as changes in land use, agricultural practices or hunting activities, movement of livestock that may influence host-tick-virus dynamics. In order to be able to design prevention and control measures targeted at the disease, mapping of endemic areas and risk assessment for CCHF in Europe should be completed. Furthermore, areas at risk for further CCHF expansion should be identified and human, vector and animal surveillance be strengthened. C1 [Maltezou, H. C.] Hellen Ctr Dis Control & Prevent, Athens, Greece. [Andonova, L.] Med Univ, Sofia, Bulgaria. [Andraghetti, R.] WHO, Copenhagen, Denmark. [Bouloy, M.] Inst Pasteur, Paris, France. [Ergonul, O.] Marmara Univ, Istanbul, Turkey. [Jongejan, F.] Univ Utrecht, Utrecht Ctr Tick Borne Dis, Utrecht, Netherlands. [Kalvatchev, N.] Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria. [Nichol, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Niedrig, M.] Robert Koch Inst, D-1000 Berlin, Germany. [Platonov, A.] Minist Publ Hlth Russia, Cent Res Inst Epidemiol, Moscow, Russia. [Thomson, G.] Hlth Protect Agcy, London, England. [Leitmeyer, K.; Zeller, H.] European Ctr Dis Control & Prevent, Stockholm, Sweden. RP Maltezou, HC (reprint author), Hellen Ctr Dis Control & Prevent, Athens, Greece. EM helen-maltezou@ath.forthnet.gr OI Platonov, Alexander/0000-0001-7450-0081 NR 28 TC 63 Z9 65 U1 0 U2 9 PU EUR CENTRE DIS PREVENTION & CONTROL PI STOCKHOLM PA TOMTEBODAVAGEN 11A, STOCKHOLM, 171 83, SWEDEN SN 1560-7917 J9 EUROSURVEILLANCE JI Eurosurveillance PD MAR 11 PY 2010 VL 15 IS 10 BP 48 EP 51 AR 19504 PG 4 WC Infectious Diseases SC Infectious Diseases GA 580LF UT WOS:000276449100007 PM 20403306 ER PT J AU May, AL Kuklina, EV Yoon, PW AF May, A. L. Kuklina, E. V. Yoon, P. W. TI Prevalence of Abnormal Lipid Levels Among Youths-United States, 1999-2006 (Reprinted from MMWR, vol 59, pg 29-33, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [May, A. L.; Kuklina, E. V.; Yoon, P. W.] CDC, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP May, AL (reprint author), CDC, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 1 TC 2 Z9 2 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 10 PY 2010 VL 303 IS 10 BP 930 EP 933 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 565UC UT WOS:000275319300008 ER PT J AU Gregg, EW Kirtland, KA Cadwell, BL Burrows, NR Barker, LE Thompson, TJ Geiss, L Pan, L AF Gregg, E. W. Kirtland, K. A. Cadwell, B. L. Burrows, N. Rios Barker, L. E. Thompson, T. J. Geiss, L. Pan, L. TI Estimated County-Level Prevalence of Diabetes and Obesity-United States, 2007 (Reprinted from MMWR, vol 58, pg 1259-1263, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Gregg, E. W.; Kirtland, K. A.; Cadwell, B. L.; Burrows, N. Rios; Barker, L. E.; Thompson, T. J.; Geiss, L.] CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Pan, L.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Gregg, EW (reprint author), CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 11 TC 4 Z9 4 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 10 PY 2010 VL 303 IS 10 BP 933 EP 935 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 565UC UT WOS:000275319300009 ER PT J AU Trout, DB Schulte, PA AF Trout, Douglas B. Schulte, Paul A. TI Medical surveillance, exposure registries, and epidemiologic research for workers exposed to nanomaterials SO TOXICOLOGY LA English DT Article; Proceedings Paper CT Symposium on Potential Hazard of Nanoparticles CY OCT 05-08, 2008 CL Rhodes, GREECE DE Nanotechnology; Surveillance; Epidemiology; Carbon nanotubes; Fibrosis ID PUBLIC-HEALTH SURVEILLANCE; WALLED-CARBON-NANOTUBES; EXHALED NITRIC-OXIDE; ENGINEERED NANOPARTICLES; PHYSICIAN RECOGNITION; PULMONARY RESPONSES; ULTRAFINE PARTICLES; HAZARD SURVEILLANCE; DIESEL EXHAUST; AIR-POLLUTION AB While there is a growing body of information about hazards of nanomaterials, little is known about the risks to workers exposed to them. However, workers are the first people in society that are being exposed to the growing inventory of "nano-enabled" products in commerce. The number of workers involved in the investigation, manufacture, production, and disposal of these types of products is growing. Although toxicologic research is still the highest priority, it is time to actively anticipate the health needs of workers. To date, precautionary risk management approaches have been widely advocated. Now there is a need to initiate an evolving process to identify the issues in medical surveillance, utilization of exposure registries, and the conduct of epidemiologic research. Each of these are related complex endeavors that build on the toxicologic evidence and extent of exposure. There is a need to assess the scientific basis and research needs for determining early functional changes, organ system and disease responses for use in targeted medical surveillance. There is also need for development of criteria for extrapolating toxicological data in biological systems to predict the risk of adverse outcomes in humans. In the meantime, exposure registries may be pivotal in helping societies act in the face of uncertainty in a precautionary manner, but legal, ethical, and logistical issues need resolution. Epidemiologic research will build on these efforts and may ultimately contribute critical definitive rationale for medical screening, risk assessment and management. Published by Elsevier Ireland Ltd. C1 [Trout, Douglas B.; Schulte, Paul A.] Ctr Dis Control & Prevent, NIOSH, Cincinnati, OH 45226 USA. RP Schulte, PA (reprint author), Ctr Dis Control & Prevent, NIOSH, 4676 Columbia Pkwy,MSC-14, Cincinnati, OH 45226 USA. EM PSchulte@cdc.gov NR 63 TC 35 Z9 36 U1 0 U2 14 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAR 10 PY 2010 VL 269 IS 2-3 SI SI BP 128 EP 135 DI 10.1016/j.tox.2009.12.006 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 588IU UT WOS:000277063900005 PM 20006668 ER PT J AU Lu, PJ Jain, N Cohn, AC AF Lu, Peng-jun Jain, Nidhi Cohn, Amanda C. TI Meningococcal conjugate vaccination among adolescents aged 13-17 years, United States, 2007 SO VACCINE LA English DT Article DE Meningococcal conjugate vaccine; Vaccination; Coverage; Adolescent vaccination ID IMMUNIZATION PRACTICES; CHILDHOOD VACCINATION; COVERAGE LEVELS; SCHOOL YEAR; CHILDREN; ADULTS; VACCINES; CARE AB Background: An estimated 1000-2000 cases of invasive meningococcal diseases occur annually in the United States. In 2005, a new quadrivalent meningococcal conjugate vaccine (MCV4) was approved and, because of supply constraints, was recommended for routine vaccination of some groups of adolescents. In August 2007, vaccination recommendations were expanded for all adolescents 11-18 years. Methods: We analyzed data from the 2007 National Immunization Survey-Teen (NIS-Teen), a nationally representative random digit dialed telephone survey. Estimates of MCV4 coverage were assessed from provider-reported vaccination histories. A multivariable logistic regression analysis and predictive marginal model were performed to identify factors independently associated with MCV4 vaccination. Results: Provider-reported vaccination histories were available for 2947 adolescents aged 13-17 years with a response rate of 55.9%. Overall, MCV4 coverage was 32.4% (95% confidence interval (CI) = 30.2-34.7%) in 2007. Vaccination coverage was similar among adolescents aged 13-14 years compared to those aged 15-17 years (32.1% vs. 32.6%, respectively). Coverage was 30.6% for non-Hispanic whites, 35.9% for non-Hispanic blacks, and 36.1% for Hispanics; however, these variations were not statistically significant. Characteristics independently associated with a higher likelihood of MCV4 vaccination included having >= 2 physician contacts in the past year, having a well child visit at age 11-12 years, and ever having a doctor recommendation for meningitis vaccination of the adolescent. Conclusions: In 2007, MCV4 coverage among 13-17 years old increased 20.7 percentage points from 2006. Achieving high vaccination coverage among adolescents will be challenging. Targeting adolescents with no health insurance and no recent healthcare provider visits may be important to increase coverage. Published by Elsevier Ltd. C1 [Lu, Peng-jun; Jain, Nidhi] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, CCID, Atlanta, GA 30333 USA. [Cohn, Amanda C.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, CCID, Atlanta, GA 30333 USA. RP Lu, PJ (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, CCID, 1600 Clifton Rd NE,Mail Stop E-62, Atlanta, GA 30333 USA. EM lhp8@cdc.gov NR 46 TC 12 Z9 12 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 8 PY 2010 VL 28 IS 11 BP 2350 EP 2355 DI 10.1016/j.vaccine.2009.12.032 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 573MW UT WOS:000275919000012 PM 20044055 ER PT J AU Levy, C Gains, K Crocco, V Brown, J Lawaczeck, E Ray, W Miller, M Klaber, M Doussette, A Ralston, C Marsden-Haug, N Fritz, C Watson, C MacNeil, A Mills, J Rollin, PE Nichol, S Knust, B AF Levy, C. Gains, K. Crocco, V. Brown, J. Lawaczeck, E. Ray, W. Miller, M. Klaber, M. Doussette, A. Ralston, C. Marsden-Haug, N. Fritz, C. Watson, C. MacNeil, A. Mills, J. Rollin, P. E. Nichol, S. Knust, B. TI Hantavirus Pulmonary Syndrome in Five Pediatric Patients-Four States, 2009 (Reprinted from MMWR, vol 58, pg 1409-1412, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Levy, C.] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Knust, B.] CDC, Atlanta, GA 30333 USA. RP Levy, C (reprint author), Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 3 PY 2010 VL 303 IS 9 BP 826 EP 828 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 562NU UT WOS:000275059500006 ER PT J AU Mohammed, H Leichliter, JS Schmidt, N Farley, TA Kissinger, P AF Mohammed, Hamish Leichliter, Jami S. Schmidt, Norine Farley, Thomas A. Kissinger, Patricia TI Does Patient-Delivered Partner Treatment Improve Disclosure for Treatable Sexually Transmitted Diseases? SO AIDS PATIENT CARE AND STDS LA English DT Article ID CONTROLLED-TRIAL; TRICHOMONAS-VAGINALIS; CHLAMYDIAL INFECTION; SELF-DISCLOSURE; HIV; NOTIFICATION; SEROSTATUS; BEHAVIORS; WOMEN; STD AB The objective of this research was to determine the factors associated with disclosure of three treatable sexually transmitted diseases (STDs). Data were obtained from two intervention trials to determine the ideal means of partner referral. Men diagnosed with urethritis and women diagnosed with trichomoniasis at public clinics in New Orleans, Louisiana were randomly assigned to partner referral (PR), booklet-enhanced partner referral (BEPR), or patient-delivered partner treatment (PDPT). Participants were asked about sex partners at baseline, then whether they disclosed to them at follow-up. The male trial was conducted from December 2001 to March 2004 and the female trial from December 2001 to August 2004. Data on men and women were analyzed separately. Nine hundred seventy-seven men and 463 women-reporting information on 1991 and 521 sex partners-were respectively enrolled in each trial. Disclosure occurred to 57.8% and 87.3% of their partners, respectively. Most men (68.3%) reported having two or more partners and disclosure was more likely to occur in: those who reported only one sex partner (adjusted odds ratio [aOR] 95% confidence interval [CI]: 1.54 [1.10, 2.16]); those in steady relationships (OR [95% CI]: 1.37 [1.08,1.74]); and those assigned PDPT (OR [95% CI]: 2.71 [1.93,3.82]). Most women reported having only one partner (86.8%) and disclosure was more likely to occur in steady relationships (OR [95% CI]: 2.65 [1.24,5.66]), and when sex was reinitiated with partners during the follow-up period (OR [95% CI]: 3.30 [1.54,7.09]). The provision of PDPT was associated with increased STD disclosure among men but not among women. Both men and women were less likely to disclose to casual partners. Women had high rates of disclosure irrespective of intervention arm. C1 [Mohammed, Hamish] Ross Univ, Sch Vet Med, Basseterre, St Kitts, W Ind Assoc St. [Leichliter, Jami S.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Schmidt, Norine; Kissinger, Patricia] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA. [Farley, Thomas A.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Community Hlth Sci, New Orleans, LA USA. RP Mohammed, H (reprint author), Ross Univ, Sch Vet Med, POB 334, Basseterre, St Kitts, W Ind Assoc St. EM hamohammed@rossvet.edu.kn FU Centers for Disease Control and Prevention [R30/CCR619146] FX Supported by Centers for Disease Control and Prevention (cooperative agreement R30/CCR619146 "Optimizing Partner Treatment Strategies''). NR 32 TC 12 Z9 12 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD MAR PY 2010 VL 24 IS 3 BP 183 EP 188 DI 10.1089/apc.2009.0237 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 566EI UT WOS:000275352500007 PM 20214486 ER PT J AU Flegal, KM Graubard, BI Williamson, DF Gail, MH AF Flegal, Katherine M. Graubard, Barry I. Williamson, David F. Gail, Mitchell H. TI Sources of differences in estimates of obesity-associated deaths from first National Health and Nutrition Examination Survey (NHANES I) hazard ratios SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID UNITED-STATES; BODY-MASS; OVERWEIGHT; MORTALITY; SMOKING; RISK; UNDERWEIGHT; POPULATION; FRACTIONS; MORBIDITY AB Background: Estimates of obesity-associated deaths in the United States for 1991 were published by Allison et al (JAMA 1999; 282: 1530-8) and subsequently for 2000 by Mokdad et al (JAMA 2004; 291: 1238-45). Flegal et al (JAMA 2005; 293: 1861-7) then published lower estimates of obesity-associated deaths for 2000. All 3 studies incorporated data from the first National Health and Nutrition Examination Survey (NHANES I). Objective: The objective was to clarify the effects of methodologic differences between the 3 studies in estimates of obesity-associated deaths in the US population by using NHANES I hazard ratios. Design: The earlier reports used imputed smoking data for much of the NHANES I sample rather than the available reported data and applied a method of calculating attributable fractions that did not adjust for the effects of age, sex, and smoking on mortality in the target US population and did not account for effect modification by age. The effects of these and other methodologic factors were examined. Results: The NHANES I hazard ratios in the earlier reports were too low, probably because of the imputed smoking data. The low hazard ratios obscured the magnitude and direction of the bias arising from the incompletely adjusted attributable fraction method. When corrected hazard ratios were used, the incompletely adjusted attributable fraction method overestimated obesity-associated mortality in the target population by > 100,000 deaths. Conclusion: Methodologic sources of bias in the reports by Allison et al and Mokdad et al include the assessment of smoking status in NHANES I and the method of calculating attributable fractions. Am J Clin Nutr 2010;91:519-27. C1 [Flegal, Katherine M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Graubard, Barry I.; Gail, Mitchell H.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Williamson, David F.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. RP Flegal, KM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 4201, Hyattsville, MD 20782 USA. EM kmf2@cdc.gov RI Flegal, Katherine/A-4608-2013; OI Flegal, Katherine/0000-0002-0838-469X NR 33 TC 14 Z9 14 U1 0 U2 5 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2010 VL 91 IS 3 BP 519 EP 527 DI 10.3945/ajcn.2009.28222 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 557YM UT WOS:000274706500005 PM 20107197 ER PT J AU Flegal, KM Wei, R Ogden, CL Freedman, DS Johnson, CL Curtin, LR AF Flegal, Katherine M. Wei, Rong Ogden, Cynthia L. Freedman, David S. Johnson, Clifford L. Curtin, Lester R. TI Extreme percentiles of the 2000 Centers for Disease Control and Prevention BMI chart and the LMS method Reply SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Letter ID BODY-MASS INDEX; ADOLESCENT OVERWEIGHT; PENALIZED LIKELIHOOD; GROWTH REFERENCE; CHILDREN; OBESITY; HEIGHT C1 [Flegal, Katherine M.; Wei, Rong; Ogden, Cynthia L.; Johnson, Clifford L.; Curtin, Lester R.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Freedman, David S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Flegal, KM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM kmf2@cdc.gov RI Flegal, Katherine/A-4608-2013; OI Flegal, Katherine/0000-0002-0838-469X NR 10 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2010 VL 91 IS 3 BP 815 EP 816 DI 10.3945/ajcn.2009.29042 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 557YM UT WOS:000274706500041 ER PT J AU Frost, SS Goins, RT Hunter, RH Hooker, SP Bryant, LL Kruger, J Pluto, D AF Frost, Stephanie S. Goins, R. Turner Hunter, Rebecca H. Hooker, Steven P. Bryant, Lucinda L. Kruger, Judy Pluto, Delores TI Effects of the Built Environment on Physical Activity of Adults Living in Rural Settings SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article DE Rural; Built Environment.; Physical Activity; Walking; Prevetion Research ID AFRICAN-AMERICAN WOMEN; OLDER-ADULTS; UNITED-STATES; NEIGHBORHOOD ENVIRONMENT; HEALTH-PROFESSIONALS; NORTHERN CALIFORNIA; PROMOTING WALKING; SOUTH-CAROLINA; BELGIAN ADULTS; ETHNIC-GROUPS AB Objective. To conduct a systematic review of the literature to examine the influence of the built environment (BE) on the physcial activity (PA) of adults in rural settings. Data Source. Key word searches of Academic Search Premier, PubMed, CINAHL, web of Science, and Sport Discus were conducted. Study Inclusion and Exclusion Criteria. Studies published prior to June 2008 were included if they assessed one or more elements of the BE, examined relationships between the BE and PA, and focused on rural locales. Studies only reporting descriptive statistics of assessing the reliability of measures were excluded. Data Extraction. Objective(s), sample size, sampling technique, geographic location, and definition of rural were extracted from each study, Methods of assessment and outcomes were extracted from the quantitative literature, and overarching themes were identified from the qualitative literature. Data Synthesis. Key characteristics and findings from the data are summarized in Tables 1 through 3. Results. Twenty studies met inclusion and exclusion criteria. Positive associations were found among pleasant aesthetics, trails, safety/crime, parks, and walkable destinations. Conclusions. Research in this area is limited. Associations among elements of the BE and PA among adults appear to differ between rural and urban areas. Considerations for future studies include identifying parameters used to define rural, longitudinal research, and more diverse geographic sampling. Development and refinement of BE assessment tools specific to rural locations are also warranted. (Am J Health Promot. 2010:[4]:267-283.) C1 [Frost, Stephanie S.] W Virginia Univ, Dept Community Med, Morgantown, WV 26506 USA. [Hunter, Rebecca H.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Hooker, Steven P.; Pluto, Delores] Univ S Carolina, Columbia, SC 29208 USA. [Bryant, Lucinda L.] Univ Colorado, Denver, CO 80202 USA. [Kruger, Judy] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Frost, SS (reprint author), W Virginia Univ, Dept Community Med, POB 9127, Morgantown, WV 26506 USA. EM sfrost@hsc.wvu.edu OI Hooker, Steven/0000-0001-9969-6244 FU NCCDPHP CDC HHS [U48DP000052] NR 134 TC 53 Z9 53 U1 6 U2 45 PU AMER JOURNAL HEALTH PROMOTION INC PI TROY PA PO BOX 1254, TROY, MI 48099-1254 USA SN 0890-1171 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD MAR-APR PY 2010 VL 24 IS 4 BP 267 EP 283 DI 10.4278/ajhp.08040532 PG 17 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 572DA UT WOS:000275806000007 PM 20232609 ER PT J AU Wang, GJ Zhang, ZF Ayala, C AF Wang, Guijing Zhang, Zefeng Ayala, Carma TI Hospitalization Costs Associated With Hypertension as a Secondary Diagnosis Among Insured Patients Aged 18-64 Years SO AMERICAN JOURNAL OF HYPERTENSION LA English DT Article DE blood pressure; hypertension; ICD-9 codes; inpatient costs; propensity score matching ID BLOOD-PRESSURE; HEART-FAILURE; RISK-FACTORS; ECONOMIC BURDEN; DISEASE; CARE; COMPLICATIONS; MORTALITY; OUTCOMES; IMPACT AB BACKGROUND We estimated the hospitalization costs associated with hypertension as a secondary diagnosis among insured adults aged 18-64 years by using data from 2005 MarketScan Commercial Claims and Encounters (CCAE) inpatient admissions METHODS We analyzed costs for four patient groups (N = 455,944) (i)all selected patients; (ii) patients with the primary diagnosis of ischemic heart disease (IHD), (iii) patients with the primary diagnosis of cerebrovascular disease, and (iv) patients with neither IHD nor cerebrovascular disease as the primary diagnosis We conducted propensity score matching to control possible bias in cost estimates due to sample selections and estimated the costs of hypertension by using a regression model on the matched populations that controlled for subjects' age, sex, length of hospital stay, Charlson comorbidity index (CCI), region of residence, and urbanization of residence RESULTS For all patients with hypertension as a secondary diagnosis, the estimated average annual hospitalization cost per patient was $21,094, of which $2,734 (13%, P < 0 01) was associated with hypertension The estimated average costs were $31,106 for patients with a primary diagnosis of IHD, $17,298 for those with a primary diagnosis of cerebrovascular disease, and $18,693 for those without a primary diagnosis of IHD or cerebrovascular disease; hypertension-associated costs for these patients were $3,540 (11.4%, P < 0 01), $1,133 (6 5%, P < 0.01), and $2,254 (12 1 %; P < 0 01), respectively CONCLUSIONS Hypertension-associated hospitalization costs are substantial among insured US patients aged 18-64 years with hypertension as a secondary diagnosis and suggest a need for cost-effective programs to prevent, manage, and control hypertension C1 [Wang, Guijing; Zhang, Zefeng; Ayala, Carma] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Wang, GJ (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 37 TC 18 Z9 18 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0895-7061 J9 AM J HYPERTENS JI Am. J. Hypertens. PD MAR PY 2010 VL 23 IS 3 BP 275 EP 281 DI 10.1038/ajh.2009.241 PG 7 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 561CH UT WOS:000274952500017 PM 20010701 ER PT J AU Lehman, EJ Huy, J Levy, E Viet, SM Mobley, A McCleery, TZ AF Lehman, Everett J. Huy, Janice Levy, Elizabeth Viet, Susan M. Mobley, Amy McCleery, Truda Z. TI Bloodborne pathogen risk reduction activities in the body piercing and tattooing industry SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Bloodborne pathogens; OSHA standards; infection control; body art; tattoo; body piercing ID INFECTION-CONTROL; ST-PAUL; MINNEAPOLIS AB Background: This study examines how well regulations for bloodborne pathogens (BBPs), established primarily to reduce exposure risk for health care workers, are being followed by workers and employers in the tattooing and body piercing industry. Method: Twelve shops performing tattooing and/or body piercing (body art) in Pennsylvania and Texas were assessed for compliance with 5 administrative and 10 infection control standards for reducing exposure to BBPs. Results: All shops demonstrated compliance with infection control standards, but not with administrative standards, such as maintaining an exposure control plan, offering hepatitis B vaccine, and training staff. Shops staffed with members of professional body art organizations demonstrated higher compliance with the administrative standards. Shops in locations where the body art industry was regulated and shops in nonregulated locations demonstrated similar compliance, as did contractor- and employee-staffed shops. Conclusions: Regulations to control occupational exposure to BBPs have been in place since 1991. This study corroborates noncompliance with some standards within the body art industry reported by previous studies. Without notable enforcement, regulation at national, state, or local levels does not affect compliance. In this study, the factor most closely associated with compliance with administrative regulations was the artist's membership in a professional body art association. C1 [Lehman, Everett J.] NIOSH, Ctr Dis Control & Prevent, Div Surveillance Hazard Evaluat & Field Studi, Industrywide Studies Branch, Cincinnati, OH 45226 USA. [Viet, Susan M.] WESTAT Corp, Rockville, MD 20850 USA. [Huy, Janice; McCleery, Truda Z.] NIOSH, Ctr Dis Control & Prevent, Off Director, Cincinnati, OH 45226 USA. RP Lehman, EJ (reprint author), NIOSH, Ctr Dis Control & Prevent, Div Surveillance Hazard Evaluat & Field Studi, Industrywide Studies Branch, 4676 Columbia Pkwy,R-13, Cincinnati, OH 45226 USA. EM Elehman@cdc.gov FU National Institute for Occupational Safety and Health; US Government FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. All funds supporting this project were provided by the US Government. NR 16 TC 4 Z9 4 U1 2 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2010 VL 38 IS 2 BP 130 EP 138 DI 10.1016/j.ajic.2009.07.008 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 559WR UT WOS:000274859500007 PM 19913330 ER PT J AU Wendelboe, AM Smelser, C Lucero, CA McDonald, LC AF Wendelboe, Aaron M. Smelser, Chad Lucero, Cynthia A. McDonald, L. Clifford TI Cluster of necrotizing enterocolitis in a neonatal intensive care unit: New Mexico, 2007 SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Human milk fortifier; outbreak; infant; case series; infection control ID INFANTS; EPIDEMIOLOGY AB Background: Although the cause of necrotizing enterocolitis (NEC) is unknown, infection control practices have been shown to play an important role in containing many outbreaks. We investigated the etiology of a cluster of NEC in a level 3 neonatal intensive care unit and monitored for new cases following the implementation of enhanced infection control measures. Methods: Investigators performed a chart and laboratory review for neonates with a diagnosis of NEC during January 1, 2007, to February 13, 2007, to identify risk factors. Enhanced environmental cleaning, cohorting of infants and nurses, and increased attention to hand hygiene were instituted. Commercial feeding products in the unit were tested for bacterial contamination. Close monitoring for new cases continued for 2 months following the identification of the cluster. Results: Eleven cases of NEC were identified during the study period. Patients had a median of 5 disease risk factors (range, 3-8). Four distinct pathogens were detected in blood or stool specimens from 4 different patients. One sample of human milk fortifier (HMF) tested contained a colony count of Bacillus cereus at the US Food and Drug Administration's upper microbiologic limit for contamination. Seven (65%) patients received HMF before symptom onset, and 9 (82%) patients received 1 or more types of liquid formula. Only 1 new case was identified during the period of close monitoring. Conclusion: A microbiologic cause was not identified, and, although the cluster might have resolved spontaneously, enhanced infection control and changing batches of HMF might have played a role in controlling this outbreak. C1 [Wendelboe, Aaron M.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, EIS Field Assignments Branch, Atlanta, GA USA. [Wendelboe, Aaron M.; Smelser, Chad] New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM USA. [Lucero, Cynthia A.; McDonald, L. Clifford] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. RP Wendelboe, AM (reprint author), Univ Oklahoma, Hlth Sci Ctr, 801 NE 13th St,CHB 323, Oklahoma City, OK 73104 USA. EM Aaron-wendelboe@ouhsc.edu NR 18 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2010 VL 38 IS 2 BP 144 EP 148 DI 10.1016/j.ajic.2009.06.009 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 559WR UT WOS:000274859500009 PM 19822381 ER PT J AU Hoerger, TJ Wittenborn, JS Segel, JE Burrows, NR Imai, K Eggers, P Pavkov, ME Jordan, R Hailpern, SM Schoolwerth, AC Williams, DE AF Hoerger, Thomas J. Wittenborn, John S. Segel, Joel E. Burrows, Nilka R. Imai, Kumiko Eggers, Paul Pavkov, Meda E. Jordan, Regina Hailpern, Susan M. Schoolwerth, Anton C. Williams, Desmond E. CA Ctr Dis Control & Prevent CKD Init TI A Health Policy Model of CKD: 1. Model Construction, Assumptions, and Validation of Health Consequences SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE Chronic kidney disease; cost-effectiveness; model; validation ID CHRONIC KIDNEY-DISEASE; LEFT-VENTRICULAR HYPERTROPHY; CORONARY HEART-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; RENAL-DISEASE; US ADULTS; NATIONAL-HEALTH; UNITED-STATES; PREVALENCE AB Background: A cost-effectiveness model that accurately represents disease progression, outcomes, and associated costs is necessary to evaluate the cost-effectiveness of interventions for chronic kidney disease (CKD). Study Design: We developed a microsimulation model of the incidence, progression, and treatment of CKD. The model was validated by comparing its predictions with survey and epidemiologic data sources. Setting & Population: US patients. Model, Perspective, & Timeframe: The model follows up disease progression in a cohort of simulated patients aged 30 until age 90 years or death. The model consists of 7 mutually exclusive states representing no CKD, 5 stages of CKD, and death. Progression through the stages is governed by a person's glomerular filtration rate and albuminuria status. Diabetes, hypertension, and other risk factors influence CKD and the development of CKD complications in the model. Costs are evaluated from the health care system perspective. Intervention: Usual care, including incidental screening for persons with diabetes or hypertension. Outcomes: Progression to CKD stages, complications, and mortality. Results: The model provides reasonably accurate estimates of CKD prevalence by stage. The model predicts that 47.1% of 30-year-olds will develop CKD during their lifetime, with 1.7%, 6.9%, 27.3%, 6.9%, and 4.4% ending at stages 1-5, respectively. Approximately 11% of persons who reach stage 3 will eventually progress to stage 5. The model also predicts that 3.7% of persons will develop end-stage renal disease compared with an estimate of 3.0% based on current end-stage renal disease lifetime incidence. Limitations: The model synthesizes data from multiple sources rather than a single source and relies on explicit assumptions about progression. The model does not include acute kidney failure. Conclusion: The model is well validated and can be used to evaluate the cost-effectiveness of CKD interventions. The model also can be updated as better data for CKD progression become available. Am J Kidney Dis 55: 452-462. (C) 2010 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. C1 [Hoerger, Thomas J.; Wittenborn, John S.; Segel, Joel E.] RTI Int, Res Triangle Pk, NC 27709 USA. [Burrows, Nilka R.; Pavkov, Meda E.; Jordan, Regina; Hailpern, Susan M.; Williams, Desmond E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Imai, Kumiko] UNICEF Swaziland, Mbabane, Swaziland. [Eggers, Paul] NIDDKD, Bethesda, MD 20892 USA. [Schoolwerth, Anton C.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. RP Hoerger, TJ (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM tjh@rti.org FU CDC [200-2002-00776] FX This research was supported by funding (contract 200-2002-00776) from the CDC. NR 39 TC 30 Z9 30 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2010 VL 55 IS 3 BP 452 EP 462 DI 10.1053/j.ajkd.2009.11.016 PG 11 WC Urology & Nephrology SC Urology & Nephrology GA 563DW UT WOS:000275109000010 PM 20116911 ER PT J AU Hoerger, TJ Wittenborn, JS Segel, JE Burrows, NR Imai, K Eggers, P Pavkov, ME Jordan, R Hailpern, SM Schoolwerth, AC Williams, DE AF Hoerger, Thomas J. Wittenborn, John S. Segel, Joel E. Burrows, Nilka R. Imai, Kumiko Eggers, Paul Pavkov, Meda E. Jordan, Regina Hailpern, Susan M. Schoolwerth, Anton C. Williams, Desmond E. CA Ctr Dis Control & Prevent CKD Init TI A Health Policy Model of CKD: 2. The Cost-Effectiveness of Microalbuminuria Screening SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE Chronic kidney disease; cost-effectiveness; model; microalbuminuria; screening; renal; end-stage renal disease (ESRD) ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; CONVERTING ENZYME-INHIBITORS; RANDOMIZED CONTROLLED-TRIAL; NONDIABETIC RENAL-DISEASE; SERUM CREATININE; UNITED-STATES; NEPHROPATHY; OUTCOMES; PROTEINURIA AB Background: Microalbuminuria screening may detect chronic kidney disease in its early stages, allowing for treatment that delays or prevents disease progression. The cost-effectiveness of microalbuminuria screening has not been determined. Study Design: A cost-effectiveness model simulating disease progression and costs. Setting & Population: US patients. Model, Perspective, and Timeframe: The microsimulation model follows up disease progression and costs in a cohort of simulated patients from age 50 to 90 years or death. Costs are evaluated from the health care system perspective. Intervention: Microalbuminuria screening at 1-, 2-, 5-, or 10-year intervals followed by treatment with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. We considered universal screening, as well as screening targeted at persons with diabetes, persons with hypertension but no diabetes, and persons with neither diabetes nor hypertension. Outcomes: Costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios. Results: For the full model population, universal screening increases costs and increases QALYs. Universal annual screening starting at age 50 years has a cost-effectiveness ratio of $73,000/QALY relative to no screening and $145,000/QALY relative to usual care. Cost-effectiveness ratios improved with longer screening intervals. Relative to no screening, targeted annual screening has cost-effectiveness ratios of $21,000/QALY, $55,000/QALY, and $155,000/QALY for persons with diabetes, those with hypertension, and those with neither current diabetes nor current hypertension, respectively. Limitations: Results necessarily are based on a microsimulation model because of the long time horizon appropriate for chronic kidney disease. The model includes only health care costs. Conclusions: Microalbuminuria screening is cost-effective for patients with diabetes or hypertension, but is not cost-effective for patients with neither diabetes nor hypertension unless screening is conducted at longer intervals or as part of existing physician visits. Am J Kidney Dis 55: 463-473. (C) 2010 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. C1 [Hoerger, Thomas J.; Wittenborn, John S.; Segel, Joel E.] RTI Int, Res Triangle Pk, NC 27709 USA. [Burrows, Nilka R.; Pavkov, Meda E.; Jordan, Regina; Hailpern, Susan M.; Williams, Desmond E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Imai, Kumiko] UNICEF Swaziland, Mbabane, Swaziland. [Eggers, Paul] NIDDKD, Bethesda, MD 20892 USA. [Schoolwerth, Anton C.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. RP Hoerger, TJ (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM tjh@rti.org FU CDC [200-2002-00776] FX This research was supported by funding (contract 200-2002-00776) from the CDC. NR 39 TC 54 Z9 54 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2010 VL 55 IS 3 BP 463 EP 473 DI 10.1053/j.ajkd.2009.11.017 PG 11 WC Urology & Nephrology SC Urology & Nephrology GA 563DW UT WOS:000275109000011 PM 20116910 ER PT J AU Jolly, SE Burrows, NR Chen, SC Li, SY Jurkovitz, CT Narva, AS Norris, KC Shlipak, MG AF Jolly, Stacey E. Burrows, Nilka Rios Chen, Shu-Cheng Li, Suying Jurkovitz, Claudine T. Narva, Andrew S. Norris, Keith C. Shlipak, Michael G. TI Racial and Ethnic Differences in Albuminuria in Individuals With Estimated GFR Greater Than 60 mL/min/1.73 m(2): Results From the Kidney Early Evaluation Program (KEEP) SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE Albuminuria; health disparities; Kidney Early Evaluation Program (KEEP); screening ID GLOMERULAR-FILTRATION-RATE; SERUM CREATININE VALUES; RENAL-DISEASE; NONDIABETIC INDIVIDUALS; CARDIOVASCULAR EVENTS; GENERAL-POPULATION; AMERICAN-INDIANS; NATIONAL-HEALTH; HEART-FAILURE; UNITED-STATES AB Background: Albuminuria is an important marker for chronic kidney disease and progression to end-stage renal disease in the general population; understanding racial and ethnic differences can help inform efforts to reduce health disparities. We sought to estimate independent associations of race/ethnicity with albuminuria to determine whether observed differences were attributable to known kidney disease risk factors. Methods: This cross-sectional study included 64,161 Kidney Early Evaluation Program (KEEP) participants, 2000-2008, with estimated glomerular filtration rate >= 60 mL/min/1.73 m(2), not on regular dialysis therapy, and without a previous kidney transplant. Albuminuria (urine albumin-creatinine ratio >= 30 mg/g) was examined by self-reported race and ethnicity. Covariates were age, sex, educational level, body mass index, diabetes status or glucose level, hypertension status or blood pressure measurement, smoking status, health insurance status, and geographic region. Results: Albuminuria prevalences were 8% (n = 2,303) in whites, 11% (n = 2,310) in African Americans, 9% (n = 730) in Hispanics, 10% (n = 381) in Asians, and 15% (n = 344) in American Indians/ Alaska Natives. Compared with whites, odds of albuminuria were higher for all groups after multivariate adjustment. Odds were highest for American Indians/Alaska Natives (adjusted OR, 1.93; 95% CI, 1.70-2.20), then Asians (adjusted OR, 1.42; 95% CI, 1.26-1.61), African Americans (adjusted OR, 1.38; 95% CI, 1.29-1.47), and Hispanics (adjusted OR, 1.19; 95% CI, 1.08-1.31). Conclusions: In the KEEP study population, albuminuria prevalence was higher in African Americans, Hispanics, Asians, and American Indians/Alaska Natives than in non-Hispanic whites, suggesting a need for screening for early detection of kidney damage, especially in people at increased risk, in the community primary care setting. Am J Kidney Dis 55(S2):S15-S22. (c) 2010 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. C1 [Jolly, Stacey E.] Cleveland Clin, Inst Med, Cleveland, OH 44195 USA. [Burrows, Nilka Rios] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Chen, Shu-Cheng; Li, Suying] Minneapolis Med Res Fdn Inc, Chron Dis Res Grp, Minneapolis, MN USA. [Jurkovitz, Claudine T.] Christiana Care Hlth Syst, Ctr Outcomes Res, Newark, DE USA. [Narva, Andrew S.] NIDDK, Bethesda, MD USA. [Norris, Keith C.] Charles R Drew Univ Med & Sci, Dept Internal Med, Los Angeles, CA 90059 USA. [Shlipak, Michael G.] Univ Calif San Francisco, San Francisco VA Med Ctr, San Francisco, CA 94143 USA. RP Jolly, SE (reprint author), Cleveland Clin, Inst Med, 9500 Euclid Ave,G10, Cleveland, OH 44195 USA. EM jollys@ccf.org FU National Kidney Foundation Inc; Amgen; Abbott; Novartis; Siemens; Genentech; Genzyme; Nephroceuticals; Pfizer; LifeScan; Suplena; National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK 066488] FX The KEEP is a program of the National Kidney Foundation Inc and is supported by Amgen, Abbott, Novartis, Siemens, Genentech, Genzyme, Nephroceuticals, Pfizer, LifeScan, and Suplena. Dr Shlipak's work was supported by the American Heart Association Established Investigator Award and R01 DK 066488 from the National Institute of Diabetes and Digestive and Kidney Diseases. NR 41 TC 18 Z9 19 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2010 VL 55 IS 3 SU 2 BP S15 EP S22 DI 10.1053/j.ajkd.2009.09.034 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 559WU UT WOS:000274859800003 PM 20172444 ER PT J AU Stevens, LA Li, SY Wang, CC Huang, C Becker, BN Bomback, AS Brown, WW Burrows, NR Jurkovitz, CT McFarlane, SI Norris, KC Shlipak, M Whaley-Connell, AT Chen, SC Bakris, GL McCullough, PA AF Stevens, Lesley A. Li, Suying Wang, Changchun Huang, Cindy Becker, Bryan N. Bomback, Andrew S. Brown, Wendy Weinstock Burrows, Nilka Rios Jurkovitz, Claudine T. McFarlane, Samy I. Norris, Keith C. Shlipak, Michael Whaley-Connell, Adam T. Chen, Shu-Cheng Bakris, George L. McCullough, Peter A. TI Prevalence of CKD and Comorbid Illness in Elderly Patients in the United States: Results From the Kidney Early Evaluation Program (KEEP) SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE Aged; chronic kidney disease; comorbidity ID GLOMERULAR-FILTRATION-RATE; HIGH BLOOD-PRESSURE; SERUM CREATININE; OLDER-ADULTS; RISK-FACTOR; CYSTATIN-C; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; NATIONAL-HEALTH; HEART-FAILURE AB Background: Elderly individuals with chronic kidney disease (CKD) have high rates of comorbid conditions, including cardiovascular disease and its risk factors, and CKD-related complications. In individuals aged >= 65 years, we sought to describe the prevalence of CKD determined from laboratory test results in the Kidney Early Evaluation Program (KEEP; n = 27,017) and National Health and Nutrition Examination Survey (NHANES) 1999-2006 (n = 5,538) and the prevalence of diagnosed CKD determined from billing codes in the Medicare 5% sample (n = 1,236,946). In all 3 data sources, we also explored comorbid conditions and CKD-related complications. Methods: CKD was identified as decreased estimated glomerular filtration rate (< 60 mL/min/1.73 m(2)) or increased albumin-creatinine ratio in KEEP and NHANES; CKD was identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes in Medicare. Investigated comorbid conditions included diabetes, hypertension, high cholesterol level, coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral vascular disease, and cancer, and CKD-related complications included anemia, hypocalcemia, hyperphosphatemia, and hyperparathyroidism. Results: The prevalence of CKD was similar to 44% in both KEEP and NHANES participants, and the prevalence of diagnosed CKD was 7% in Medicare beneficiaries. In all 3 data sets, the prevalence of CKD or diagnosed CKD was higher in participants aged >= 80 years and those with comorbid conditions. For KEEP and NHANES participants, the prevalence of most comorbid conditions and CKD complications increased with decreasing estimated glomerular filtration rate. For participants with CKD stages 3-5, a total of 29.2% (95% CI, 27.8-30.6) in KEEP and 19.9% (95% CI, 17.0-23.1) in NHANES had anemia, 0.7% (95% CI, 0.4-0.9) and 0.6% (95% CI, 0.3-1.3) had hypocalcemia, 5.4% (95% CI, 4.7-6.1) and 6.4% (95% CI, 5.1-8.0) had hyperphosphatemia, and 52.0% (95% CI, 50.4-53.6) and 30.0% (95% CI, 25.9-34.3) had hyperparathyroidism, respectively. Conclusions: CKD is common in the elderly population and is associated with high frequencies of concomitant comorbid conditions and biochemical abnormalities. Because CKD is not commonly diagnosed, greater emphasis on physician education may be beneficial. Am J Kidney Dis 55(S2):S23-S33. (c) 2010 by the National Kidney Foundation, Inc. C1 [Stevens, Lesley A.] Tufts Med Ctr, Div Nephrol, Boston, MA 02111 USA. [Li, Suying; Wang, Changchun; Chen, Shu-Cheng] Minneapolis Med Res Fdn Inc, Chron Dis Res Grp, Minneapolis, MN USA. [Becker, Bryan N.] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI USA. [Bomback, Andrew S.] Columbia Univ Coll Phys & Surg, Dept Med, Div Nephrol, New York, NY 10032 USA. [Brown, Wendy Weinstock] Jesse Brown Vet Adm Med Ctr, Chicago, IL USA. [Burrows, Nilka Rios] Ctr Dis Control & Prevent, Atlanta, GA USA. [Jurkovitz, Claudine T.] Christiana Care Hlth Syst, Ctr Outcomes Res, Newark, DE USA. [McFarlane, Samy I.] SUNY Downstate & Kings Cty Hosp Ctr, Div Endocrinol, Brooklyn, NY USA. [Norris, Keith C.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Shlipak, Michael] Vet Assoc Med Ctr, San Francisco, CA USA. [Whaley-Connell, Adam T.] Univ Missouri, Columbia Sch Med, Harry S Truman VA Med Ctr, Columbia, MO USA. [Bakris, George L.] Univ Chicago, Pritzker Sch Med, Dept Med, Hypertens Dis Unit, Chicago, IL 60637 USA. [McCullough, Peter A.] William Beaumont Hosp, Dept Med, Div Cardiol, Royal Oak, MI 48072 USA. [McCullough, Peter A.] William Beaumont Hosp, Dept Med, Div Nutr, Royal Oak, MI 48072 USA. [McCullough, Peter A.] William Beaumont Hosp, Dept Med, Div Prevent Med, Royal Oak, MI 48072 USA. RP Stevens, LA (reprint author), Tufts Med Ctr, Div Nephrol, 800 Washington St,Box 391, Boston, MA 02111 USA. EM lstevens1@tuftsmedicalcenter.org OI Whaley-Connell, Adam/0000-0001-8955-5560 FU National Institute of Diabetes and Digestive and Kidney Diseases [K23-DK081017]; National Kidney Foundation Inc; Amgen; Abbott; Novartis; Siemens; Genentech; Genzyme; Nephroceuticals; Pfizer; LifeScan; Suplena FX This study was supported by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (K23-DK081017; Kidney Function and Aging). KEEP is a program of the National Kidney Foundation Inc and is supported by Amgen, Abbott, Novartis, Siemens, Genentech, Genzyme, Nephroceuticals, Pfizer, LifeScan, and Suplena. NR 42 TC 93 Z9 98 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2010 VL 55 IS 3 SU 2 BP S23 EP S33 DI 10.1053/j.ajkd.2009.09.035 PG 11 WC Urology & Nephrology SC Urology & Nephrology GA 559WU UT WOS:000274859800004 PM 20172445 ER PT J AU O'Connor, AC Layton, CM Osbeck, TJ Hoyle, TM Rasulnia, B AF O'Connor, Alan C. Layton, Christine M. Osbeck, Todd J. Hoyle, Therese M. Rasulnia, Bobby TI Health Plan Use of Immunization Information Systems for Quality Measurement SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID PRIVATE PROVIDER PARTICIPATION; REGISTRIES; COSTS; BUSINESS; SAVINGS AB Objective: To evaluate a health plan's business case for using a state immunization information system (IIS) as the primary data source for members' immunization histories. Study Design: Case study of Priority Health, a Michigan managed care organization, to investigate use of IIS data for Healthcare Effectiveness Data and Information Set (HEDIS) compliance, quality measurement, and a provider incentive program. Methods: Primary data were collected through key informant interviews and group discussions with Priority Health and IIS managers. Priority Health's information systems were populated with claims data and supplemental data, before chart reviews, to simulate immunization and health plan quality measures for 2004 to 2007 in the absence of IIS data. Simulated rates were compared with historical rates that included IIS data. The study included a cost-benefit analysis. Results: For 2007, IIS data increased observed immunization rates from 6.49 to 54.13 percentage points for childhood immunizations and 57.63 to 77.97 percentage points for adolescent immunizations. The HEDIS administrative rate for childhood immunizations doubled from 43.38% in 2003 to 88.08% in 2007. The most significant source of savings was in administration of the health plan's Physician Incentive Program, which saw 18,881 fewer chart reviews from 2004 to 2007 when IIS data were used compared with when they were not used. Total costs of using IIS data were estimated to be $14,318 and net benefits were $107,854-corresponding to a benefit-to-cost ratio of 8.06. Conclusions: Health plans using a state IIS as a single point of data entry may realize cost savings and have improved assurance of immunization coverage. (Am J Manag Care. 2010; 16(3): 217-224) C1 [O'Connor, Alan C.; Layton, Christine M.] RTI Int, San Francisco, CA 94104 USA. [Osbeck, Todd J.] Prior Hlth, Grand Rapids, MI USA. [Hoyle, Therese M.] Hoyle Consulting Inc, Delton, MI USA. [Rasulnia, Bobby] Ctr Dis Control & Prevent, Atlanta, GA USA. RP O'Connor, AC (reprint author), RTI Int, 114 Sansome St,Ste 500, San Francisco, CA 94104 USA. EM oconnor@rti.org FU Centers for Disease Control and Prevention FX This study was funded by the Centers for Disease Control and Prevention. NR 22 TC 5 Z9 5 U1 0 U2 3 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD MAR PY 2010 VL 16 IS 3 BP 217 EP 224 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 567XY UT WOS:000275483400007 PM 20225917 ER PT J AU Shin, M Siffel, C Correa, A AF Shin, Mikyong Siffel, Csaba Correa, Adolfo TI Survival of Children With Mosaic Down Syndrome SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Letter C1 [Shin, Mikyong; Siffel, Csaba; Correa, Adolfo] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Shin, Mikyong] ORISE, Oak Ridge, TN USA. [Siffel, Csaba] Comp Sci Corp, Atlanta, GA USA. RP Shin, M (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E86, Atlanta, GA 30333 USA. EM mshin@cdc.gov NR 7 TC 21 Z9 21 U1 0 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD MAR PY 2010 VL 152A IS 3 BP 800 EP 801 DI 10.1002/ajmg.a.33295 PG 2 WC Genetics & Heredity SC Genetics & Heredity GA 576OV UT WOS:000276155200042 PM 20186777 ER PT J AU Fang, J Alderman, MH Keenan, NL Ayala, C AF Fang, Jing Alderman, Michael H. Keenan, Nora L. Ayala, Carma TI Acute Myocardial Infarction Hospitalization in the United States, 1979 to 2005 SO AMERICAN JOURNAL OF MEDICINE LA English DT Article DE Acute myocardial infarction; Hospitalization; In-hospital case-fatality ID CORONARY-HEART-DISEASE; POPULATION-BASED PERSPECTIVE; 30-YEAR TRENDS 1975-2005; SUDDEN CARDIAC DEATH; TEMPORAL TRENDS; SURVIVAL RATES; CASE-FATALITY; MEDICAL-CARE; RISK-FACTORS; MORTALITY AB BACKGROUND: We reported earlier that there was no decline of acute myocardial infarction hospitalization from 1988 to 1997. We now extend these observations to document trends in acute myocardial infarction hospitalization rates and in-hospital case-fatality rates for 27 years from 1979 to 2005. METHODS: We determined hospitalization rates for acute myocardial infarction by age and gender using data from the National Hospital Discharge Survey and US civilian population from 1979 to 2005, aggregated by 3-year groupings. We also assessed comorbid, complications, cardiac procedure use, and in-hospital case-fatality rates. RESULTS: Age-adjusted hospitalization rate for acute myocardial infarction identified by primary International Classification of Diseases code was 215 per 100,000 people in 1979-1981 and increased to 342 in 1985-1987. Thereafter, the rate stabilized for the next decade and then declined slowly after 1996 to 242 in 2003-2005. Trends were similar for men and women, although rates for men were almost twice that of women. Hospitalization rates increased substantially with age and were the highest among those aged 85 years or more. Although median hospital stay decreased from 12 to 4 clays, intensity of hospital care increased, including use of coronary angioplasty, coronary bypass, and thrombolytics therapy. During the period, reported comorbidity from diabetes and hypertension increased. Acute myocardial infarction complicated by heart failure increased, and cardiogenic shock decreased. Altogether, the in-hospital case-fatality rate declined. CONCLUSION: During the past quarter century, hospitalization for acute myocardial infarction increased until the mid- 1990s, but has declined since then. At the same time, in-hospital case-fatality rates declined steadily. This decline has been associated with more aggressive therapeutic intervention. Published by! Elsevier Inc. . The American Journal of Medicine (2010) 123, 259-266 C1 [Fang, Jing; Keenan, Nora L.; Ayala, Carma] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Alderman, Michael H.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. RP Fang, J (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE,MS K-47, Atlanta, GA 30341 USA. EM jfang@cdc.gov NR 33 TC 42 Z9 44 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD MAR PY 2010 VL 123 IS 3 BP 259 EP 266 DI 10.1016/j.amjmed.2009.08.018 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 572EE UT WOS:000275809400016 PM 20193835 ER PT J AU Grosse, SD AF Grosse, Scott D. TI What is the value for money of prenatal carrier screening for spinal muscular atrophy? Too soon to say SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Editorial Material ID COST-EFFECTIVENESS ANALYSIS; DOWN-SYNDROME; HEALTH; DIAGNOSIS; BENEFITS; UTILITY; POLICY; ISSUES; TESTS; WOMEN C1 Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Grosse, SD (reprint author), Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. NR 31 TC 3 Z9 3 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD MAR PY 2010 VL 202 IS 3 BP 209 EP 211 DI 10.1016/j.ajog.2010.01.031 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 568IV UT WOS:000275516900003 PM 20207235 ER PT J AU Chu, SY Goodwin, MM D'Angelo, DV AF Chu, Susan Y. Goodwin, Mary M. D'Angelo, Denise V. TI Physical Violence Against US Women Around the Time of Pregnancy, 2004-2007 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID INTIMATE PARTNER VIOLENCE; HEALTH-CARE; ABUSE AB Background: Previous research shows that the prevalence of intimate partner violence (IPV) around the time of pregnancy varies from 4% to 9%, but no studies have distinguished between abuse rates by former versus current partners. Purpose: This study aims to estimate the prevalence of IPV among U.S. women shortly before and during pregnancy and to compare the rates and predictors of abuse perpetrated by current partners with the rates and predictors of abuse perpetrated by former partners. Methods: Using data from 27 states and New York City, the prevalence of physical abuse by current and former intimate male partners was estimated among 134,955 women who delivered a singleton, full-term infant in 2004-2007. Multivariable logistic regression was used to determine the demographic, pregnancy-related, and stress factors that predicted the risk of IPV. Results: Prevalence of IPV from either a former or current partner was 5.3% before and 3.6% during pregnancy. Prevalence of abuse by a former partner was consistently higher than the prevalence of abuse by a current partner. The three strongest predictors of IPV during pregnancy were the woman's partner not wanting the pregnancy (current: AOR=3.47, 95% CI=3.13, 3.85; former: AOR=3.22, 95% CI=2.90, 3.76); having had a recent divorce or separation (current: AOR=3.23, 95% CI=2.92, 3.58; former: AOR=3.54, 95% CI=3.20, 3.91); and being close to someone having a drug or alcohol problem (current: AOR=3.05, 95% CI=2.78, 3.36; former: AOR=2.97, 95% CI=2.70, 127). Maternal characteristics (age, education, race, marital status, woman did not want the pregnancy) were less important predictors. Conclusions: Assessments of abuse should ask specifically about actions by both current and ex-partners. (Am J Prev Med 2010;38(3):317-322) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Chu, Susan Y.; Goodwin, Mary M.; D'Angelo, Denise V.] CDC, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Chu, SY (reprint author), CDC, Div Reprod Hlth, 4770 Buford Highway,Mailstop K-23, Atlanta, GA 30341 USA. EM syc1@cdc.gov NR 22 TC 21 Z9 21 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2010 VL 38 IS 3 BP 317 EP 322 DI 10.1016/j.amepre.2009.11.013 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 566OW UT WOS:000275383100010 PM 20171534 ER PT J AU Backinger, CL Malarcher, AM AF Backinger, Cathy L. Malarcher, Ann M. TI The Things That Get Measured Are the Things That Get Done SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article C1 [Backinger, Cathy L.] NCI, Tobacco Control Res Branch, Behav Res Program, Div Canc Control & Populat Sci, Rockville, MD 20852 USA. [Malarcher, Ann M.] CDC, Epidemiol Branch, Off Smoking & Hlth, Atlanta, GA 30333 USA. RP Backinger, CL (reprint author), NCI, Tobacco Control Res Branch, Behav Res Program, Div Canc Control & Populat Sci, 6130 Execut Blvd,EPN 4050, Rockville, MD 20852 USA. EM backingc@mail.nih.gov FU National Cancer Institute; CDC FX The authors thank Allison Rose and Rene Arrazola for their assistance in reviewing the state and national survey questions, Ami Hurd for her assistance in gathering and organizing background materials for the commentary, and Dr. C. Tracy Orleans and Dr. Gary Giovino for their input into the conceptualization of the major themes for the commentary.; The findings and conclusions in this report are those of the authors and do not necessarily represent any official position of the National Cancer Institute, the NIH, or the CDC.; This work was supported by the National Cancer Institute and the CDC. NR 18 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2010 VL 38 IS 3 SU 3 BP S433 EP S436 DI 10.1016/j.amepre.2009.12.005 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 566OX UT WOS:000275383200020 PM 20176319 ER PT J AU Backinger, CL Thornton-Bullock, A Miner, C Orleans, CT Siener, K DiClemente, CC Phillips, TM Rowden, JN Arkin, E AF Backinger, Cathy L. Thornton-Bullock, Amber Miner, Cindy Orleans, C. Tracy Siener, Karen DiClemente, Carlo C. Phillips, Todd M. Rowden, Jessica N. Arkin, Elaine TI Building Consumer Demand for Tobacco-Cessation Products and Services The National Tobacco Cessation Collaborative's Consumer Demand Roundtable SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SMOKING-CESSATION; CIGARETTE-SMOKING; SMOKERS; PROGRAMS; IMPACT; SALES C1 [Phillips, Todd M.; Rowden, Jessica N.; Arkin, Elaine] Acad Educ Dev, Washington, DC 20009 USA. [Backinger, Cathy L.] NCI, Bethesda, MD 20892 USA. [Miner, Cindy] Natl Inst Drug Abuse, Bethesda, MD USA. [DiClemente, Carlo C.] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA. [Thornton-Bullock, Amber] Amer Legacy Fdn, Washington, DC USA. [Orleans, C. Tracy] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA. [Siener, Karen] CDC, Atlanta, GA 30333 USA. RP Phillips, TM (reprint author), Acad Educ Dev, 1825 Connecticut Ave NW, Washington, DC 20009 USA. EM tphillip@aed.org NR 32 TC 18 Z9 19 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2010 VL 38 IS 3 SU 3 BP S307 EP S311 DI 10.1016/j.amepre.2009.12.002 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 566OX UT WOS:000275383200002 PM 20176301 ER PT J AU Chen, Z Roy, K Crawford, CAG AF Chen, Zhuo Roy, Kakoli Crawford, Carol A. Gotway TI Examining the Role of Gender in Career Advancement at the Centers for Disease Control and Prevention SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article AB During the past decade, efforts to promote gender parity in the healing and public health professions have met with only partial success. We provide a critical update regarding the status of women in the public health profession by exploring gender-related differences in promotion rates at the nation's leading public health agency, the Centers for Disease Control and Prevention (CDC). Using personnel data drawn from CDC, we found that the gender gap in promotion has diminished across time and that this reduction can be attributed to changes in individual characteristics (e.g., higher educational levels and more federal work experience). However, a substantial gap in promotion that cannot be explained by such characteristics has persisted, indicating continuing barriers in women's career advancement. (Am J Public Health. 2010;100:426-434. doi:10.2105/AJPH.2008.156190) C1 [Chen, Zhuo; Roy, Kakoli; Crawford, Carol A. Gotway] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Chen, Z (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd NE,MS E94, Atlanta, GA 30333 USA. EM zchen1@cdc.gov NR 28 TC 1 Z9 1 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 2010 VL 100 IS 3 BP 426 EP 434 DI 10.2105/AJPH.2008.156190 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 564YD UT WOS:000275253800016 PM 20075327 ER PT J AU Torrone, EA Thomas, JC Kaufman, JS Pettifor, AE Leone, PA Hightow-Wiedman, LB AF Torrone, Elizabeth A. Thomas, James C. Kaufman, Jay S. Pettifor, Audrey E. Leone, Peter A. Hightow-Wiedman, Lisa B. TI Glen or Glenda: Reported Gender of Sex Partners in Two Statewide HIV Databases SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article AB Objectives. We assessed agreement of reported gender of sex partners in 2 statewide HIV databases linked by client identifiers. Methods. Counseling, testing, and referral (CTR) records on all men aged 18 to 30 years who tested newly positive for HIV in North Carolina between 2000 and 2005 were matched to data abstracted from partner counseling and referral services (PCRS) records. We compared client-reported gender of sex partners at the time of testing (CTR records) with those reported during postdiagnosis partner notification (PCRS records). Results. PCRS records appeared to be a more complete measure of the gender of sex partners. Of the 212 men who told their HIV test counselor that they had only had female sex partner or partners in their lifetime, 62 (29.2%) provided contact information for male sex partner(s) during partner notification. Conclusions. During the test counseling risk assessment, many men did not fully report the gender of their sex partners; this suggests that CTR data may not fully capture clients' risk behaviors. (Am J Public Health. 2010;100:525-530. doi: 10.2105/AJPH.2009.162552) C1 [Torrone, Elizabeth A.; Thomas, James C.; Pettifor, Audrey E.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Kaufman, Jay S.] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada. [Leone, Peter A.; Hightow-Wiedman, Lisa B.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [Leone, Peter A.] N Carolina Dept Hlth & Human Serv, Raleigh, NC USA. RP Torrone, EA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,M-S E02, Atlanta, GA 30333 USA. EM etorrone@cdc.gov OI Kaufman, Jay/0000-0003-1606-401X FU University of North Carolina at Chapel Hill Centers for AIDS Research [P30 AI50410] FX This study was funded by the University of North Carolina at Chapel Hill Centers for AIDS Research (grant P30 AI50410). NR 26 TC 4 Z9 4 U1 2 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 2010 VL 100 IS 3 BP 525 EP 530 DI 10.2105/AJPH.2009.162552 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 564YD UT WOS:000275253800029 PM 20075318 ER PT J AU Cummings, KJ Donat, WE Ettensohn, DB Roggli, VL Ingram, P Kreiss, K AF Cummings, Kristin J. Donat, Walter E. Ettensohn, David B. Roggli, Victor L. Ingram, Peter Kreiss, Kathleen TI Pulmonary Alveolar Proteinosis in Workers at an Indium Processing Facility SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE pulmonary alveolar proteinosis; indium ID TIN-OXIDE; EXPOSURE; ASSOCIATION; PARTICLES; PNEUMONIA; FIBROSIS; DUST; LUNG AB Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism. C1 [Cummings, Kristin J.; Kreiss, Kathleen] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Donat, Walter E.; Ettensohn, David B.] Brown Univ, Dept Med, Warren Alpert Med Sch, Providence, RI 02912 USA. [Roggli, Victor L.; Ingram, Peter] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA. RP Cummings, KJ (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS 2800, Morgantown, WV 26505 USA. EM cvx5@cdc.gov FU National Institute for Occupational Safety and Health FX Supported by intramural funding from the National Institute for Occupational Safety and Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 38 TC 68 Z9 80 U1 0 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD MAR 1 PY 2010 VL 181 IS 5 BP 458 EP 464 DI 10.1164/rccm.200907-1022CR PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 563YN UT WOS:000275176700008 PM 20019344 ER PT J AU Siri, JG Wilson, ML Murray, S Rosen, DH Vulule, JM Slutsker, L Lindblade, KA AF Siri, Jose G. Wilson, Mark L. Murray, Susan Rosen, Daniel H. Vulule, John M. Slutsker, Laurence Lindblade, Kim A. TI Significance of Travel to Rural Areas as a Risk Factor for Malarial Anemia in an Urban Setting SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; CROSS-SECTIONAL SURVEY; CEREBRAL MALARIA; CHILDHOOD MALARIA; WESTERN KENYA; GAMBIAN CHILDREN; TRANSMISSION; EPIDEMIOLOGY; AFRICA; MORBIDITY AB The epidemiology of malaria in urban environments is poorly characterized, yet increasingly problematic. We conducted an unmatched case-control study of risk factors for malarial anemia with high parasitemia in urban Kisumu, Kenya, from June 2002 through February 2003. Cases (n = 80) were hospital patients with a hemoglobin level <= 8 g/dL and a Plasmodium parasite density >= 10,000/mu L. Controls (n = 826) were healthy respondents to a concurrent citywide knowledge, attitude, and practice survey. Children who reported spending at least one night per month in a rural area were especially at risk (35% of cases; odds ratio = 9.3, 95% confidence interval [CI] = 4.4-19.7, P < 0.0001), and use of mosquito coils, bed net ownership, and house construction were non-significant, potentially indicating that malaria exposure during rural travel comprises an important element of risk. Control of severe malaria in an urban setting may be complicated by Plasmodium infections acquired elsewhere. Epidemiologic studies of urban malaria in low transmission settings should take travel history into account. C1 [Wilson, Mark L.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA. [Murray, Susan] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA. [Rosen, Daniel H.; Slutsker, Laurence] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Vulule, John M.] Kenya Govt Med Res Ctr, Ctr Vector Biol & Control Res, Kisumu, Kenya. [Siri, Jose G.] Int Inst Syst Anal, Hlth & Global Change Project, Laxenburg, Austria. [Lindblade, Kim A.] Ctr Dis Control & Prevent, Reg Off Cent Amer & Panama, Unit 3190, Dpo, AA USA. RP Wilson, ML (reprint author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 109 Observ, Ann Arbor, MI 48109 USA. EM wilsonml@umich.edu OI Siri, Jose/0000-0001-7041-0310 FU CDC/KEMRI; University of Michigan through the Rackham Graduate School; Center for Research on Ethnicity, Culture and Health; Global Health Program FX This research was supported by CDC/KEMRI and by the University of Michigan through the Rackham Graduate School, the Center for Research on Ethnicity, Culture and Health, and the Global Health Program. NR 54 TC 6 Z9 6 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2010 VL 82 IS 3 BP 391 EP 397 DI 10.4269/ajtmh.2010.09-0047 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 564LE UT WOS:000275215000009 PM 20207862 ER PT J AU Kulkarni, MA Eng, JV Desrochers, RE Cotte, AH Goodson, JL Johnston, A Wolkon, A Erskine, M Berti, P Rakotoarisoa, A Ranaivo, L Peat, J AF Kulkarni, Manisha A. Eng, Jodi Vanden Desrochers, Rachelle E. Cotte, Annett Hoppe Goodson, James L. Johnston, Adam Wolkon, Adam Erskine, Marcy Berti, Peter Rakotoarisoa, Andriamahefa Ranaivo, Louise Peat, Jason TI Contribution of Integrated Campaign Distribution of Long-Lasting Insecticidal Nets to Coverage of Target Groups and Total Populations in Malaria-Endemic Areas in Madagascar SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TREATED BEDNETS; SCALING-UP; TANZANIA; CHILDREN; AFRICA AB In October 2007, Madagascar conducted a nationwide integrated campaign to deliver measles vaccination, mebendazole, and vitamin A to children six months to five years of age. In 59 of the I It districts, long-lasting insecticidal nets (LLINs) were delivered to children less than five years of age in combination with the other interventions. A community-based, cross-sectional survey assessed LLIN ownership and use six months post-campaign during the rainy season. LLIN ownership was analyzed by wealth quintile to assess equity. In the 59 districts, 76.8% of households possessed at least one LLIN from any source and 56.4% of households possessed a campaign net. Equity of campaign net ownership was evident. Post-campaign, the LLIN use target of >= 80% by children less than five years of age and a high level of LLIN use (69%) by pregnant women were attained. Targeted LLIN distribution further contributed to total population coverage (60%) through use of campaign nets by all age groups. C1 [Kulkarni, Manisha A.; Berti, Peter] HealthBridge, Ottawa, ON K1N 7B7, Canada. [Eng, Jodi Vanden; Cotte, Annett Hoppe; Wolkon, Adam] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Goodson, James L.] Ctr Dis Control & Prevent, Div Global Immunizat, Atlanta, GA USA. [Desrochers, Rachelle E.] Univ Ottawa, Dept Biol, Ottawa, ON, Canada. [Johnston, Adam; Erskine, Marcy] Canadian Res Cross, Ottawa, ON, Canada. [Rakotoarisoa, Andriamahefa; Ranaivo, Louise] Inst Hyg, Serv Lutte Contre Paludisme, Minist Sante Planning Familial & Protect Sociale, Antananarivo, Madagascar. [Peat, Jason] Int Federat Red Cross & Red Crescent Soc, Geneva, Switzerland. RP Kulkarni, MA (reprint author), HealthBridge, 1105-1 Nicholas St, Ottawa, ON K1N 7B7, Canada. EM mkulkarni@healthbridge.ca; jev8@cdc.gov; rdesr104@uottawa.ca; cjn8@cdc.gov; jgoodson@cdc.gov; adam.johnston@redcross.ca; aow5@cdc.gov; marcy.erskine@gmail.com; pberti@healthbridge.ca; and@caramail.com; ranaivol22@yahoo.fr; jason.peat@ifrc.org OI Kulkarni, Manisha/0000-0002-5084-4960 NR 29 TC 29 Z9 29 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2010 VL 82 IS 3 BP 420 EP 425 DI 10.4269/ajtmh.2010.09-0597 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 564LE UT WOS:000275215000014 PM 20207867 ER PT J AU Jones, JL Holland, GN AF Jones, Jeffrey L. Holland, Gary N. TI Short Report: Annual Burden of Ocular Toxoplasmosis in the United States SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID GONDII INFECTION; BRAZIL AB Toxoplasmosis is the most common retinal infection in the United States, and it can severely impact vision. We used data from population-based studies. outbreaks, and the U.S. census to estimate the burden of Toxoplasma gondii infection and ocular toxoplasmosis. We estimate that 1,075,242 persons are infected with T. gondii, 21,505 persons have ocular lesions (both asymptomatic and symptomatic), and 4,839 (range = 2,150-7,527) persons develop symptomatic ocular toxoplasmosis each year in the United States. Toxoplasmosis contributes a significant burden to eve disease in the United States. C1 [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Div Parasit Dis, NCVED, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA. [Holland, Gary N.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90095 USA. [Holland, Gary N.] Univ Calif Los Angeles, David Geffen Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA. Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Jones, JL (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, NCVED, Natl Ctr Zoonot Vector Borne & Enter Dis, Mailstop F-22,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM jlj1@cdc.gov; uveitis@jsei.ucla.edu NR 14 TC 56 Z9 57 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2010 VL 82 IS 3 BP 464 EP 465 DI 10.4269/ajtmh.2010.09-0664 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 564LE UT WOS:000275215000021 PM 20207874 ER PT J AU Jentes, ES Davis, XHM MacDonald, S Snyman, PJ Nelson, H Quarry, D Lai, I van Vliet, EWN Balaban, V Marano, C Mues, K Kozarsky, P Marano, N AF Jentes, Emily S. Davis, Xiaohong M. MacDonald, Susan Snyman, P. Johann Nelson, Hugh Quarry, Doug Lai, Irene van Vliet, Erik W. N. Balaban, Victor Marano, Cinzia Mues, Katherine Kozarsky, Phyllis Marano, Nina TI Health Risks and Travel Preparation Among Foreign Visitors and Expatriates During the 2008 Beijing Olympic and Paralympic Games SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID GEOSENTINEL SURVEILLANCE NETWORK; SUMMER OLYMPICS; INFECTIOUS-DISEASES; RETURNED TRAVELERS; EXPERIENCE; KNOWLEDGE; ATTITUDES; PREVENTION; AIRPORT AB During the 2008 Olympic and Paralympic Games, we conducted surveillance of illnesses among travelers at six Beijing clinics. Surveys asked about demographic, pre-travel, and vaccination information, and physician-provided diagnoses. Of 807 respondents, 38% and 57% were classified as foreign visitors (FV) and expatriates, respectively. Less than one-half of FV sought pre-travel advice; sources included health-care providers and friends/family. FV vaccination rate was also lows however, most vaccines given were recommended by the Centers for Disease Control and Prevention. The most common FV diagnoses were respiratory, injury/musculoskeletal, and gastrointestinal illnesses; for expatriates, injury/musculoskeletal, respiratory, and dermatologic were the most common illnesses. Respiratory illnesses in expatriates were significantly less in 2008 than during 2004-2007 (chi(2) = 10.2; P = 0.0014), suggesting that control programs may have reduced pollutants/respiratory irritants during the 2008 Games. We found no previous studies of health outcomes among expatriates living in cities with mass travel events. These findings highlight the need to continuously disseminate information to health-care providers advising travelers. C1 [Jentes, Emily S.; Davis, Xiaohong M.; Balaban, Victor; Marano, Cinzia; Mues, Katherine; Kozarsky, Phyllis; Marano, Nina] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [MacDonald, Susan] Beijing United Family Hosp & Clin, Dept Primary Care, Beijing, Peoples R China. United Family Hosp & Clin, Dept Primary Care, Int SOS, Beijing, Peoples R China. [van Vliet, Erik W. N.] Heineken Int, Amsterdam, Netherlands. [Quarry, Doug] Int SOS, Sydney, NSW, Australia. [Snyman, P. Johann; Nelson, Hugh] Beijing Int SOS Clin, Beijing, Peoples R China. Heineken Int Hlth Affairs, Amsterdam, Netherlands. Ctr Dis Control & Prevent, Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA 30333 USA. CDC, Div Global Migrat & Quarantine, Travelers Hlth Branch, Atlanta, GA 30333 USA. Int SOS, Travelers Hlth Branch, Beijing, Peoples R China. United Family Hosp & Clin, Epidem Intelligence Serv, Beijing, Peoples R China. RP Jentes, ES (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, 1600 Clifton Rd,MS E-03, Atlanta, GA 30333 USA. EM ejentes@cdc.gov OI Lai, Irene/0000-0002-2376-0593 NR 25 TC 6 Z9 6 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2010 VL 82 IS 3 BP 466 EP 472 DI 10.4269/ajtmh.2010.09-0660 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 564LE UT WOS:000275215000022 PM 20207875 ER PT J AU Green, RF Devine, O Crider, KS Olney, RS Archer, N Olshan, AF Shapira, SK AF Green, Ridgely Fisk Devine, Owen Crider, Krista S. Olney, Richard S. Archer, Natalie Olshan, Andrew F. Shapira, Stuart K. CA Natl Birth Defects Prevention Stud TI Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004 SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Congenital Abnormalities; Maternal Age; Paternal Age; Risk Factors ID MATERNAL AGE; SPONTANEOUS-ABORTION; SPONTANEOUS MUTATION; PARENTAL AGE; DNA-DAMAGE; SEX-RATIO; GASTROSCHISIS; POPULATION; MALFORMATIONS; PREVALENCE AB PURPOSE: The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age. METHODS: By using 1997 to 2004 data from the National Birth Defects Prevention Study, we tit logistic regression models with paternal and maternal age is continuous variables while adjusting tor demographic and other factors. RESULTS: Elevated odds ratios (ORs) for each year increase in paternal age were found for cleft palate (OR. 1.02, 95% confidence interval [95% CI], 1.00-1.04), diaphragmatic hernia (OR, 1.04; 95% Cl, 1.02-1.06), right ventricular outflow tract obstruction (OR, 1.03; 95% Cl, 1.01-1.04), and pulmonary valve stenosis (OR, 1.02, 95% Cl, 1.01-1.04). At younger paternal ages, each year increase in paternal age correlated with increased odds of having offspring with encephalocele, cataract, esophageal attresia, anomalous pulmonary venous return, and coarctation of the aorta, but these increased odds were not observed at older paternal ages. The effect of paternal age was modified by maternal age for gastroschisis, omphalocele, spina bifida, all orofacial clefts, and septal heart defects. CONCLUSIONS: Our findings suggest that paternal age may be a risk factor for some multifactorial birth defects. Ann Epidemiol 2010;20:241-249. (C) Published by Elsevier Inc. C1 [Green, Ridgely Fisk; Devine, Owen; Crider, Krista S.; Olney, Richard S.; Shapira, Stuart K.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Olshan, Andrew F.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Archer, Natalie] Texas Dept State Hlth Serv, Austin, TX USA. RP Green, RF (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,Mail Stop E-86, Atlanta, GA 30333 USA. EM grf1@cdc.gov RI Publications, NBDPS/B-7692-2013; OI Archer, Natalie/0000-0001-8066-5130 FU NICHD NIH HHS [R24 HD050924]; NIEHS NIH HHS [P30 ES010126, P30 ES 10126, P30 ES010126-099003] NR 41 TC 34 Z9 35 U1 2 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD MAR PY 2010 VL 20 IS 3 BP 241 EP 249 DI 10.1016/j.annepidem.2009.10.009 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 584MZ UT WOS:000276757700009 PM 20056435 ER PT J AU Mixson-Hayden, T Jain, V McCollum, AM Poe, A Nagpal, AC Dash, AP Stiles, JK Udhayakumar, V Singh, N AF Mixson-Hayden, Tonya Jain, Vidhan McCollum, Andrea M. Poe, Amanda Nagpal, Avinash C. Dash, Aditya P. Stiles, Jonathan K. Udhayakumar, Venkatachalam Singh, Neeru TI Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PAPUA-NEW-GUINEA; DIHYDROFOLATE-REDUCTASE; PFMDR1 GENE; SULFADOXINE-PYRIMETHAMINE; DIHYDROPTEROATE SYNTHASE; PFCRT GENE; ANTIMALARIAL RESISTANCE; PROGRESSIVE INCREASE; MALARIA PARASITES; MOLECULAR MARKER AB Treatment of Plasmodium falciparum is complicated by the emergence and spread of parasite resistance to many of the first-line drugs used to treat malaria. Antimalarial drug resistance has been associated with specific point mutations in several genes, suggesting that these single nucleotide polymorphisms can be useful in tracking the emergence of drug resistance. In India, P. falciparum infection can manifest itself as asymptomatic, mild, or severe malaria, with or without cerebral involvement. We tested whether chloroquine-and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR. Further, we used microsatellites surrounding the genes to determine the origins and spread of the drug-resistant genotypes in this area. Resistance to chloroquine was essentially fixed, with 95% of the isolates harboring the pfcrt K76T mutation. Resistant genotypes of dhfr, dhps, and pfmdr-1 were found in 94%, 17%, and 77% of the isolates, respectively. Drug-resistant genotypes were equally likely to be associated with cerebral malaria as with mild malaria. We found evidence of a selective sweep in pfcrt and, to a lesser degree, in dhfr, indicating high levels of resistance to chloroquine and evolving resistance to pyrimethamine. Microsatellites surrounding pfcrt indicate that the resistant genotypes (SVMNT) were most similar to those found in Papua New Guinea. C1 [Mixson-Hayden, Tonya; McCollum, Andrea M.; Poe, Amanda; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Stiles, Jonathan K.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Mixson-Hayden, Tonya; Poe, Amanda] Atlanta Res & Educ Fdn, Decatur, GA USA. [Jain, Vidhan; Singh, Neeru] NIMR, Field Stn, Jabalpur, Madhya Pradesh, India. [Nagpal, Avinash C.] Nethaji Subhash Chandra Bose Med Coll Hosp, Jabalpur, Madhya Pradesh, India. [Singh, Neeru] Reg Med Res Ctr Tribals, Jabalpur, Madhya Pradesh, India. [Dash, Aditya P.] NIMR, Delhi, India. RP Mixson-Hayden, T (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, 4770 Buford Highway,MS F-12, Chamblee, GA 30341 USA. EM zdy0@cdc.gov FU CDC Antimalarial Resistance Working Group; Atlanta Research and Education Foundation; VA Medical Center; NIH/FIC [R21TW006804-01] FX T.M.- H. was supported by the American Society for Microbiology, Coordinating Center for Infectious Diseases Postdoctoral Fellowship Program in Infectious Disease and Public Health Microbiology. Funding for this work was provided in part by the CDC Antimalarial Resistance Working Group, the Atlanta Research and Education Foundation, the VA Medical Center, and NIH/FIC grant R21TW006804-01, awarded to J.K.S. NR 66 TC 25 Z9 25 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2010 VL 54 IS 3 BP 997 EP 1006 DI 10.1128/AAC.00846-09 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 558HY UT WOS:000274733300005 PM 20038626 ER PT J AU Deyde, VM Sheu, TG Trujillo, AA Okomo-Adhiambo, M Garten, R Klimov, AI Gubareva, LV AF Deyde, Varough M. Sheu, Tiffany G. Trujillo, A. Angelica Okomo-Adhiambo, Margaret Garten, Rebecca Klimov, Alexander I. Gubareva, Larisa V. TI Detection of Molecular Markers of Drug Resistance in 2009 Pandemic Influenza A (H1N1) Viruses by Pyrosequencing SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID NEURAMINIDASE INHIBITORS; OSELTAMIVIR-RESISTANCE; UNITED-STATES; IN-VITRO; H5N1; INFECTION; SUSCEPTIBILITY; HUMANS; SURVEILLANCE; SENSITIVITY AB The M2 blockers amantadine and rimantadine and the neuraminidase (NA) inhibitors (NAIs) oseltamivir and zanamivir are approved by the FDA for use for the control of influenza A virus infections. The 2009 pandemic influenza A (H1N1) viruses (H1N1pdm) are reassortants that acquired M and NA gene segments from a Eurasian adamantane-resistant swine influenza virus. NAI resistance in the H1N1pdm viruses has been rare, and its occurrence is mainly limited to oseltamivir-exposed patients. The pyrosequencing assay has been proven to be a useful tool in surveillance for drug resistance in seasonal influenza A viruses. We provide a protocol which allows the detection of adamantane resistance markers as well as the I43T change, which is unique to the H1N1pdm M2 protein. The protocol also allows the detection of changes at residues V116, I117, E119, Q136, K150, D151, D199, I223, H275, and N295 in the NA, known to alter NAI drug susceptibility. We report on the detection of the first cases of the oseltamivir resistance-conferring mutation H275Y and the I223V change in viruses from the United States using the approach described in this study. Moreover, the assay permits the quick identification of the major NA group (V106/N248, I106/D248, or I106/N248) to which a pandemic virus belongs. Pyrosequencing is well suited for the detection of drug resistance markers and signature mutations in the M and NA gene segments of the pandemic H1N1 influenza viruses. C1 [Deyde, Varough M.; Sheu, Tiffany G.; Trujillo, A. Angelica; Okomo-Adhiambo, Margaret; Garten, Rebecca; Klimov, Alexander I.; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Gubareva, LV (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM lqg3@cdc.gov FU Centers for Disease Control and Prevention; Oak Ridge Institute for Science and Education, Oak Ridge, TN FX This work was funded by the Centers for Disease Control and Prevention. T. G. S. received financial support for this work from the Oak Ridge Institute for Science and Education, Oak Ridge, TN. NR 43 TC 77 Z9 82 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2010 VL 54 IS 3 BP 1102 EP 1110 DI 10.1128/AAC.01417-09 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 558HY UT WOS:000274733300018 PM 20028826 ER PT J AU Baldridge, GD Burkhardt, NY Labruna, MB Pacheco, RC Paddock, CD Williamson, PC Billingsley, PM Felsheim, RF Kurtti, TJ Munderloh, UG AF Baldridge, Gerald D. Burkhardt, Nicole Y. Labruna, Marcelo B. Pacheco, Richard C. Paddock, Christopher D. Williamson, Philip C. Billingsley, Peggy M. Felsheim, Roderick F. Kurtti, Timothy J. Munderloh, Ulrike G. TI Wide Dispersal and Possible Multiple Origins of Low-Copy-Number Plasmids in Rickettsia Species Associated with Blood-Feeding Arthropods SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID SPOTTED-FEVER GROUP; OBLIGATE INTRACELLULAR BACTERIA; LATERAL GENE-TRANSFER; AMBLYOMMA-AMERICANUM; GENOME SEQUENCE; UNITED-STATES; SP-NOV; DERMACENTOR-ANDERSONI; MICROBIAL COMMUNITIES; IXODES-SCAPULARIS AB Plasmids are mobile genetic elements of bacteria that can impart important adaptive traits, such as increased virulence or antibiotic resistance. We report the existence of plasmids in Rickettsia (Rickettsiales; Rickettsiaceae) species, including Rickettsia akari, "Candidatus Rickettsia amblyommii," R. bellii, R. rhipicephali, and REIS, the rickettsial endosymbiont of Ixodes scapularis. All of the rickettsiae were isolated from humans or North and South American ticks. R. parkeri isolates from both continents did not possess plasmids. We have now demonstrated plasmids in nearly all Rickettsia species that we have surveyed from three continents, which represent three of the four major proposed phylogenetic groups associated with blood-feeding arthropods. Gel-based evidence consistent with the existence of multiple plasmids in some species was confirmed by cloning plasmids with very different sequences from each of two "Ca. Rickettsia amblyommii" isolates. Phylogenetic analysis of rickettsial ParA plasmid partitioning proteins indicated multiple parA gene origins and plasmid incompatibility groups, consistent with possible multiple plasmid origins. Phylogenetic analysis of potentially host-adaptive rickettsial small heat shock proteins showed that hsp2 genes were plasmid specific and that hsp1 genes, found only on plasmids of "Ca. Rickettsia amblyommii," R. felis, R. monacensis, and R. peacockii, were probably acquired independently of the hsp2 genes. Plasmid copy numbers in seven Rickettsia species ranged from 2.4 to 9.2 per chromosomal equivalent, as determined by real-time quantitative PCR. Plasmids may be of significance in rickettsial evolution and epidemiology by conferring genetic plasticity and host-adaptive traits via horizontal gene transfer that counteracts the reductive genome evolution typical of obligate intracellular bacteria. C1 [Baldridge, Gerald D.; Burkhardt, Nicole Y.; Felsheim, Roderick F.; Kurtti, Timothy J.; Munderloh, Ulrike G.] Univ Minnesota, Dept Entomol, St Paul, MN 55108 USA. [Labruna, Marcelo B.; Pacheco, Richard C.] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Sao Paulo, Brazil. [Paddock, Christopher D.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Williamson, Philip C.; Billingsley, Peggy M.] Univ N Texas, Hlth Sci Ctr, Dept Forens & Investigat Genet, Ft Worth, TX USA. RP Baldridge, GD (reprint author), Univ Minnesota, Dept Entomol, 1980 Folwell Ave, St Paul, MN 55108 USA. EM baldr001@umn.edu RI Labruna, Marcelo/B-6241-2013; Pacheco, Richard/H-6190-2013 OI Labruna, Marcelo/0000-0002-9675-3132; Pacheco, Richard/0000-0002-7135-1516 FU NIH [RO1 AI49424] FX This research was supported by NIH grant RO1 AI49424 to U. G. M. NR 79 TC 34 Z9 34 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2010 VL 76 IS 6 BP 1718 EP 1731 DI 10.1128/AEM.02988-09 PG 14 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 564DQ UT WOS:000275193900003 PM 20097813 ER PT J AU Tai, E Pollack, LA Townsend, J Li, J Steele, CB Richardson, LC AF Tai, Eric Pollack, Lori A. Townsend, Julie Li, Jun Steele, C. Brooke Richardson, Lisa C. TI Differences in Non-Hodgkin Lymphoma Survival Between Young Adults and Children SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID CANCER CLINICAL-TRIALS; ADOLESCENTS; CHALLENGES; RITUXIMAB; THERAPY; DISEASE AB Objective: To examine differences in non-Hodgkin lymphoma (NHL) survival between young adults and children/adolescents. Design: Survival analysis using 13 Surveillance, Epidemiology, and End Results registries. Setting: Cancer survival information from population-based cancer registries from 1992 through 2001. Participants: A total of 2442 cases of NHL among children/adolescents (aged 0-19 years) and young adults (aged 20-29 years). Main Exposure: Differences in NHL survival between young adults and children. Main Outcome Measures: Comparison of 5-year survival by constructing Kaplan-Meier survival curves and modeling 5-year survival with multivariate Cox proportional hazards. Results: Young adults were more likely to die compared with children/adolescents (hazard ratio = 2.06; 95% confidence interval, 1.65-2.56) even after accounting for NHL subtype and stage at diagnosis. Persons diagnosed with stage III disease (hazard ratio = 1.71; 95% confidence interval, 1.20-2.46) and stage IV disease (hazard ratio = 3.19; 95% confidence interval, 2.47-4.13) were more likely to die compared with persons diagnosed with stage I disease. Conclusions: Being a young adult at diagnosis and having a higher stage of disease at diagnosis were associated with higher risk of death from NHL. Increasing survival with NHL is dependent on receiving appropriate cancer therapy. Therefore, efforts to address survival should include improving enrollment in clinical trials as well as increasing access to care. C1 [Tai, Eric; Pollack, Lori A.; Townsend, Julie; Li, Jun; Steele, C. Brooke; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Tai, E (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS-K57, Atlanta, GA 30341 USA. EM cvn5@cdc.gov FU Centers for Disease Control and Prevention FX Funding/Support: This work was supported by the Centers for Disease Control and Prevention. NR 28 TC 9 Z9 11 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD MAR PY 2010 VL 164 IS 3 BP 218 EP 224 PG 7 WC Pediatrics SC Pediatrics GA 562IA UT WOS:000275042300002 PM 20194253 ER PT J AU McBane, RD Wysokinski, WE Daniels, PR Litin, SC Slusser, J Hodge, DO Dowling, NF Heit, JA AF McBane, Robert D. Wysokinski, Waldemar E. Daniels, Paul R. Litin, Scott C. Slusser, Joshua Hodge, David O. Dowling, Nicole F. Heit, John A. TI Periprocedural Anticoagulation Management of Patients With Venous Thromboembolism SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY LA English DT Article DE anticoagulation; deep vein thrombosis; pulmonary embolism ID MOLECULAR-WEIGHT HEPARIN; DEEP-VEIN THROMBOSIS; INTENSITY WARFARIN THERAPY; PULMONARY-EMBOLISM; RISK-FACTORS; LONG-TERM; INTERRUPTION; PREVENTION AB Objective-Patients with venous thromboembolism (VTE) often require temporary warfarin interruption for an invasive procedure. The incidence of thromboembolism and bleeding related to periprocedural anticoagulation management of such patients is unknown. Methods and Results-In a protocol-driven, inception cohort design study, all VTE patients (n = 775) referred for periprocedural anticoagulation management (1997-2007) were followed-up to estimate the 3-month cumulative incidence of thromboembolism and bleeding. Patients were stratified by thrombus acuity (acute, <30 days; subacute, 31-90 days; or chronic >= 91 days). Decisions to provide "bridging" low-molecular-weight heparin were based on estimated thromboembolism and bleeding risk. Low-molecular-weight heparin was more often administered in acute (87%) and subacute (81%) VTE compared to chronic VTE (59%; P<0.001). The 3-month cumulative incidence of thromboembolism (1.8%), major hemorrhage (1.8%), and mortality (1.7%) were low and did not differ by management strategy. Active cancer was the only independent predictor of thrombotic recurrence (HR, 4.86; 95% CI, 1.6-14.5; P = 0.005), major hemorrhage (HR, 6.8; 95% CI, 2.1-21.7; P = 0.001), and death (HR, 32.7; 95% CI, 4.3-251.2; P = 0.0008). Conclusion-Thromboembolism, bleeding, and death among VTE patients in whom anticoagulation is temporarily interrupted for an invasive procedure is low. Cancer patients require particular care given their propensity for both clotting and bleeding. (Arterioscler Thromb Vasc Biol. 2010;30:442-448.) C1 [McBane, Robert D.] Mayo Clin, Gonda Thrombophilia Clin, Gonda Vasc Ctr, Mayo Clin Thrombophilia Ctr, Rochester, MN 55902 USA. [Hodge, David O.] Mayo Clin, Div Biostat, Dept Hlth Sci Res, Rochester, MN 55902 USA. [Dowling, Nicole F.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP McBane, RD (reprint author), Mayo Clin, Gonda Thrombophilia Clin, Gonda Vasc Ctr, Mayo Clin Thrombophilia Ctr, 200 1st St SW, Rochester, MN 55902 USA. EM mcbane.robert@mayo.edu OI Wysokinski, Waldemar/0000-0002-8119-6206 FU Centers for Disease Control and Prevention [3O-0850]; US Public Health Service; Mayo Foundation FX Funded, in part, by grants from the Centers for Disease Control and Prevention (3O-0850), US Public Health Service, and by the Mayo Foundation. NR 21 TC 32 Z9 32 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-5642 J9 ARTERIOSCL THROM VAS JI Arterioscler. Thromb. Vasc. Biol. PD MAR PY 2010 VL 30 IS 3 BP 442 EP 448 DI 10.1161/ATVBAHA.109.199406 PG 7 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 557GX UT WOS:000274658700013 PM 20139361 ER PT J AU Davis, CT Balish, AL O'Neill, E Nguyen, CV Cox, NJ Xu, XY Klimov, A Nguyen, T Donis, RO AF Davis, C. Todd Balish, Amanda L. O'Neill, Eduardo Nguyen, Cam V. Cox, Nancy J. Xu Xiyan Klimov, Alexander Nguyen, Tung Donis, Ruben O. TI Detection and Characterization of Glade 7 High Pathogenicity Avian Influenza H5N1 Viruses in Chickens Seized at Ports of Entry and Live Poultry Markets in Vietnam SO AVIAN DISEASES LA English DT Article; Proceedings Paper CT 7th International Symposium on Avian Influenza CY APR 05-08, 2009 CL Univ Georgia, Athens, GA HO Univ Georgia DE orthomyxovirus; high-pathogenicity avian influenza virus; phylogenetics; geographic distribution; H5N1; evolution; international trade; live bird markets ID MULTIPLE SUBLINEAGES; DUCK MEAT; A VIRUSES; EVOLUTION; GENETICS; CHINA; ASIA AB High pathogenicity avian influenza H5N1 has become an endemic poultry disease in several Asian countries, including Vietnam. Recently, clade 7 H5N1 viruses of the Eurasian lineage were isolated from chickens seized at ports of entry in Lang Son Province, Vietnam. Extensive nucleotide and amino acid divergence across the hemagglutinin (HA) protein gene of these isolates in comparison to previously described clade 7 viruses was identified. Glade 7 viruses are antigenically distinct from contemporary strains of H5N1 known to circulate in Vietnamese poultry (clade 1 and clade 2.3.4). Subsequent surveillance of sick poultry in live poultry markets in Hai Duong Province identified additional clade 7 isolates with HA genes very similar to the group B virus cluster detected previously at the Lang Son Province border. Antigenic analysis of the isolates from the live bird markets revealed significant cross-reactivity only between those clade 7 viruses belonging to the same subgroups. To meet pandemic response preparedness objectives, we have developed a reassortant virus from A/chicken/Vietnam/NCVD-016/2008, which could be used as a new prepandemic vaccine candidate for veterinary or human vaccination, should the need arise. Findings from these studies indicate that viruses with clade 7 HA have continued to evolve in Southeast Asian poultry, leading to significant antigenic drift relative to other H5N1 viruses currently circulating in Vietnam. C1 [Davis, C. Todd; Balish, Amanda L.; O'Neill, Eduardo; Cox, Nancy J.; Xu Xiyan; Klimov, Alexander; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Nguyen, Cam V.; Nguyen, Tung] Natl Ctr Vet Diagnost, Dept Anim Hlth, Hanoi, Vietnam. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM rvd6@cdc.gov NR 23 TC 19 Z9 19 U1 0 U2 5 PU AMER ASSOC AVIAN PATHOLOGISTS PI ATHENS PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA SN 0005-2086 J9 AVIAN DIS JI Avian Dis. PD MAR PY 2010 VL 54 IS 1 SU S BP 307 EP 312 DI 10.1637/8801-040109-ResNote.1 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 580NF UT WOS:000276455300025 PM 20521651 ER PT J AU Balish, AL Davis, CT Saad, MD El-Sayed, N Esmat, H Tjaden, JA Earhart, KC Ahmed, LE Abd El-Halem, M Ali, AHM Nassif, SA El-Ebiary, EA Taha, M Aly, MM Arafa, A O'Neill, E Xu, XY Cox, NJ Donis, RO Klimov, AI AF Balish, Amanda L. Davis, C. Todd Saad, Magdi D. El-Sayed, Nasr Esmat, Hala Tjaden, Jeffrey A. Earhart, Kenneth C. Ahmed, Lu'ay E. Abd El-Halem, Mohamed Ali, Abdel Hakem M. Nassif, Samir A. El-Ebiary, Elham A. Taha, M. Aly, Mona M. Arafa, Abdelstattar O'Neill, Eduardo Xu Xiyan Cox, Nancy J. Donis, Ruben O. Klimov, Alexander I. TI Antigenic and Genetic Diversity of Highly Pathogenic Avian Influenza A (H5N1) Viruses Isolated in Egypt SO AVIAN DISEASES LA English DT Article; Proceedings Paper CT 7th International Symposium on Avian Influenza CY APR 05-08, 2009 CL Univ Georgia, Athens, GA HO Univ Georgia DE HPAI; H5N1; Egypt; clade 2.2; pandemic; vaccine ID RECEPTOR SPECIFICITY; HONG-KONG; HEMAGGLUTININ; OUTBREAKS; DUCKS; CHINA; PCR AB Highly pathogenic avian influenza A virus (H5N1) has diverged antigenically and genetically since its initial detection in Asia in 1997. Viruses belonging to clade 2.2 in particular have been reported in numerous countries with the majority occurring in Egypt. Previous reports identified antigenic similarities between viruses belonging to clack 2.2. However, poultry and human viruses isolated in northern Egypt during 2007 and 2008 were found to he antigenically distinct from other clade 2.2 viruses from this country. Genetic analysis of the hemagglutinin revealed a high degree of nucleotide and ammo acid divergence. The antigenic changes in Egyptian viruses isolated during 2007-08 necessitated that two of these strains be considered as potential H5N1 pre-pandemic vaccine candidates. C1 [Balish, Amanda L.; Davis, C. Todd; O'Neill, Eduardo; Xu Xiyan; Cox, Nancy J.; Donis, Ruben O.; Klimov, Alexander I.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Saad, Magdi D.; Tjaden, Jeffrey A.; Earhart, Kenneth C.] NAMRU 3 Cairo, Viral & Zoonot Dis Res Program, Cairo, Egypt. [El-Sayed, Nasr; Esmat, Hala] Minist Hlth & Populat, Cairo, Egypt. [Ahmed, Lu'ay E.; Abd El-Halem, Mohamed] Minist Environm, Cairo, Egypt. [Ali, Abdel Hakem M.; Nassif, Samir A.; El-Ebiary, Elham A.; Taha, M.] Cent Lab Evaluat Vet Biol, Cairo, Egypt. [Aly, Mona M.; Arafa, Abdelstattar] Natl Lab Qual Control Poultry Prod, Cairo, Egypt. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM rvd6@cdc.gov RI Saad, Magdi/H-5561-2013; Valle, Ruben/A-7512-2013 OI Saad, Magdi/0000-0003-2111-8115; NR 25 TC 45 Z9 45 U1 0 U2 6 PU AMER ASSOC AVIAN PATHOLOGISTS PI ATHENS PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA SN 0005-2086 J9 AVIAN DIS JI Avian Dis. PD MAR PY 2010 VL 54 IS 1 SU S BP 329 EP 334 DI 10.1637/8903-042909-Reg.1 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 580NF UT WOS:000276455300028 PM 20521654 ER PT J AU Schecter, A Colacino, J Sjodin, A Needham, L Birnbaum, L AF Schecter, Arnold Colacino, Justin Sjodin, Andreas Needham, Larry Birnbaum, Linda TI Partitioning of polybrominated diphenyl ethers (PBDEs) in serum and milk from the same mothers SO CHEMOSPHERE LA English DT Article DE PBDE; Partitioning; Milk; Blood; Serum ID BROMINATED FLAME RETARDANTS; HIGH-THROUGHPUT EXTRACTION; IN-HOUSE DUST; POLYCHLORINATED-BIPHENYLS; BREAST-MILK; 2,2',4,4',5-PENTABROMODIPHENYL ETHER; DEVELOPMENTAL EXPOSURE; ADIPOSE-TISSUE; CLEANUP METHOD; BLOOD AB We and others have previously described partitioning of chemicals, including polychlorinated-p-dioxins, dibenzofurans, and biphenyls in different types of human tissues and fluids, including blood and milk. Additionally, we previously reported the blood to milk partitioning of polybrominated diphenyl ethers (PBDEs) in a group of 11 women. Partitioning is of importance in understanding the toxicokinetics of these compounds and also in clinical medicine in improving estimates of levels in different matrices including blood and milk. In this study we extend these findings, describing the levels of PBDEs detected in the serum and milk of 29 women from Texas. The median sum of the levels of the four most detected congeners (BDE 47, 99, 100, and 153) in serum was 27.8 ng g(-1) lipid (range 6.7-501.6 ng g(-1) lipid). In milk, the median sum of the levels of the same congeners was 39.7 ng g(-1) lipid (range 12.9-580.3 ng g(-1) lipid). The levels detected in breast milk in this study are similar to those we reported in 2003, where a median total PBDE level of 34 ng g-1 lipid was reported. When congener specific blood to milk partitioning ratios were calculated for BDEs 47, 99, 100, and 153, the relatively small tetrabrominated congener, BDE 47, was found in higher concentrations in milk compared to blood, while the higher molecular weight hexabrominated congener, BIDE 153, was found in approximately equal quantities in blood and milk, on a lipid normalized basis. The reason for the differential partitioning of PBDE congeners in milk and blood could be due to variation in toxicokinetics, specifically distribution based on molecular size or molecular weight. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Schecter, Arnold] Univ Texas Dallas, Sch Publ Hlth, Dallas, TX 75390 USA. [Colacino, Justin] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Sjodin, Andreas; Needham, Larry] Ctr Dis Control & Prevent, Atlanta, CA USA. [Birnbaum, Linda] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. RP Schecter, A (reprint author), Univ Texas Dallas, Sch Publ Hlth, 5323 Harry Hines,V8-112, Dallas, TX 75390 USA. EM arnold.schecter@utsouthwestern.edu RI Needham, Larry/E-4930-2011; Sjodin, Andreas/F-2464-2010 NR 35 TC 48 Z9 54 U1 3 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2010 VL 78 IS 10 BP 1279 EP 1284 DI 10.1016/j.chemosphere.2009.12.016 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 571RN UT WOS:000275772600014 PM 20079522 ER PT J AU Oraka, E King, ME Callahan, DB AF Oraka, Emeka King, Michael E. Callahan, David B. TI Asthma and Serious Psychological Distress Prevalence and Risk Factors Among US Adults, 2001-2007 SO CHEST LA English DT Article ID QUALITY-OF-LIFE; FACTOR SURVEILLANCE SYSTEM; HEALTH INTERVIEW SURVEY; UNITED-STATES; PSYCHIATRIC-DISORDERS; ANXIETY DISORDERS; LIMITATION INDEX; CHRONIC DISEASES; MENTAL-ILLNESS; PANIC-ATTACKS AB Background: For millions of adults, effective control of asthma requires a regimen of care that may be compromised by psychological factors, such as anxiety and depression. This study estimated the prevalence and risk factors for serious psychological distress (SPD) and explored their relationship to health-related quality of life (HRQOL) among adults with asthma in the United States. Methods: We analyzed data from 186,738 adult respondents from the 2001-2007 US National Health Interview Survey. We calculated weighted average prevalence estimates of current asthma and SPD by demographic characteristics and health-related factors. We used logistic regression analysis to calculate odds ratios for factors that may have predicted asthma, SPD, and HRQOL. Results: From 2001 to 2007, the average annual prevalence of cut-rent asthma was 7.0% and the average prevalence of SPD was 3.0%. Among adults with asthma, the prevalence of SPD was 7.5% (95% CI, 7.0%-8.1%). A negative association between HRQOL and SPD was found for all adults, independent of asthma status. A similar pattern of risk factors predicted SPD and the co-occurrence of SPD and asthma, although adults with asthma who reported lower socioeconomic status, a history of smoking or alcohol use, and more comorbid chronic conditions had significantly higher odds of SPD. Conclusion: This research suggests the importance of mental health screening for persons with asthma and the need for clinical and community-based interventions to target modifiable lifestyle factors that contribute to psychological distress and make asthma worse. CHEST 2010; 137(3):609-616 C1 [Oraka, Emeka; King, Michael E.; Callahan, David B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. [Oraka, Emeka] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Oraka, E (reprint author), Bldg 106,4770 Buford Hwy, Chamblee, GA 30341 USA. EM eoraka@cdc.gov FU Centers for Disease Control and Prevention; National Center for Environmental Health; Air Pollution and Respiratory Health Branch FX This work was performed and funded by the Centers for Disease Control and Prevention, National Center for Environmental Health, Air Pollution and Respiratory Health Branch. NR 56 TC 37 Z9 38 U1 1 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2010 VL 137 IS 3 BP 609 EP 616 DI 10.1378/chest.09-1777 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 567WC UT WOS:000275477100017 PM 19837824 ER PT J AU Lee, R Middleton, D Caldwell, K Dearwent, S Jones, S Lewis, B Monteilh, C Mortensen, ME Nickle, R Orloff, K Reger, M Risher, J Rogers, HS Watters, M AF Lee, Robin Middleton, Dan Caldwell, Kathleen Dearwent, Steve Jones, Steven Lewis, Brian Monteilh, Carolyn Mortensen, Mary Ellen Nickle, Richard Orloff, Kenneth Reger, Meghan Risher, John Rogers, Helen Schurz Watters, Michelle TI A review of events that expose children to elemental mercury in the United States SO CIENCIA & SAUDE COLETIVA LA English DT Review DE Children; Elemental mercury; Environmental health; Exposure; United States ID RANDOMIZED CLINICAL-TRIAL; NEW-YORK-CITY; DENTAL AMALGAM; NEVADA SCHOOL; VAPOR; INTOXICATION; ENVIRONMENT; COMMUNITIES; AMERICAN; SPILLS AB Concern for children exposed to elemental mercury prompted the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control and Prevention to review the sources of elemental mercury exposures in children, describe the location and proportion of children affected, and make recommendations on how to prevent these exposures. In this review, we excluded mercury exposures from coal-burning facilities, dental amalgams, fish consumption, medical waste incinerators, or thimerosal-containing vaccines. We reviewed federal, state, and regional programs with data on mercury releases along with published reports of children exposed to elemental mercury in the United States. We selected all mercury-related events that were documented to expose (or potentially expose) children. Primary exposure locations were at home, at school, and at others such as industrial property not adequately remediated or medical facilities. Exposure to small spills from broken thermometers was the most common scenario; however, reports of such exposures are declining. The information reviewed suggests that most releases do not lead to demonstrable harm if the exposure period is short and the mercury is properly cleaned up. Primary prevention should include health education and policy initiatives. C1 [Lee, Robin; Middleton, Dan; Dearwent, Steve; Jones, Steven; Nickle, Richard; Orloff, Kenneth; Reger, Meghan; Risher, John; Watters, Michelle] Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA. [Caldwell, Kathleen; Mortensen, Mary Ellen; Rogers, Helen Schurz] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Lee, R (reprint author), Agcy Tox Subst & Dis Registry, 4770 Buford Hwy NE,MS F-57, Atlanta, GA 30341 USA. EM RLee3@cdc.gov NR 50 TC 2 Z9 2 U1 0 U2 9 PU ABRASCO PI RIO DE JANEIRO PA RUA HESPERIA, 16-PARTE MANGUINHOS, RIO DE JANEIRO, 21050-040, BRAZIL SN 1413-8123 J9 CIENC SAUDE COLETIVA JI Cienc. Saude Coletiva PD MAR PY 2010 VL 15 IS 2 BP 585 EP 598 DI 10.1590/S1413-81232010000200035 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 594XJ UT WOS:000277574100035 PM 20414626 ER PT J AU Ng, S Cowling, BJ Fang, VJ Chan, KH Ip, DKM Cheng, CKY Uyeki, TM Houck, PM Peiris, JSM Leung, GM AF Ng, Sophia Cowling, Benjamin J. Fang, Vicky J. Chan, Kwok Hung Ip, Dennis K. M. Cheng, Calvin K. Y. Uyeki, Timothy M. Houck, Peter M. Peiris, J. S. Malik Leung, Gabriel M. TI Effects of Oseltamivir Treatment on Duration of Clinical Illness and Viral Shedding and Household Transmission of Influenza Virus SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID LONGITUDINAL DATA; RANDOMIZED-TRIAL AB Background. Large clinical trials have demonstrated the therapeutic efficacy of oseltamivir against influenza. We assessed the indirect effectiveness of oseltamivir in reducing secondary household transmission in an incident cohort of influenza index patients and their household members. Methods. We recruited index outpatients whose rapid test results were positive for influenza from February through September 2007 and January through September 2008. Household contacts were followed up for 7-10 days during 3-4 home visits to monitor symptoms. Nose and throat swabs were collected and tested for influenza by reverse-transcription polymerase chain reaction or viral culture. Results. We followed up 384 index patients and their household contacts. Index patients who took oseltamivir within 24 h of symptom onset halved the time to symptom alleviation (adjusted acceleration factor, 0.56; 95% confidence interval [CI], 0.42-0.76). Oseltamivir treatment was not associated with statistically significant reduction in the duration of viral shedding. Household contacts of index patients who had taken oseltamivir within 24 h of onset had a nonstatistically significant lower risk of developing laboratory-confirmed infection (adjusted odds ratio, 0.54; 95% CI, 0.11-2.57) and a marginally statistically significant lower risk of clinical illness (adjusted odds ratio, 0.52; 95% CI, 0.25-1.08) compared with contacts of index patients who did not take oseltamivir. Conclusions. Oseltamivir treatment is effective in reducing the duration of symptoms, but evidence of household reduction in transmission of influenza virus was inconclusive. C1 [Ng, Sophia; Cowling, Benjamin J.; Fang, Vicky J.; Ip, Dennis K. M.; Cheng, Calvin K. Y.; Leung, Gabriel M.] Univ Hong Kong, Sch Publ Hlth, Dept Community Med, Pokfulam, Hong Kong, Peoples R China. [Chan, Kwok Hung; Peiris, J. S. Malik] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Houck, Peter M.] Ctr Dis Control & Prevent, Seattle Quarantine Stn, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Seattle, WA USA. RP Cowling, BJ (reprint author), Univ Hong Kong, Sch Publ Hlth, Dept Community Med, Units 624-7,Cyberport 3, Pokfulam, Hong Kong, Peoples R China. EM bcowling@hku.hk RI Cowling, Benjamin/C-4263-2009; OI Cowling, Benjamin/0000-0002-6297-7154; Ng, Sophia/0000-0001-7817-7744; Leung, Gabriel/0000-0002-2503-6283 FU Centers for Disease Control and Prevention [1 U01 CI000439-02]; Government of the Hong Kong SAR [08070632]; US National Institutes of Health [5 U01 GM076497]; Hong Kong University Grants Committee [AoE/M-12/06] FX Financial support. This work received financial support from the Centers for Disease Control and Prevention (grant 1 U01 CI000439-02), the Research Fund for the Control of Infectious Disease, Food and Health Bureau, Government of the Hong Kong SAR (grant 08070632), US National Institutes of Health (cooperative agreement 5 U01 GM076497, Models of Infectious Disease Agent Study), and the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant AoE/M-12/06). NR 24 TC 49 Z9 50 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 1 PY 2010 VL 50 IS 5 BP 707 EP 714 DI 10.1086/650458 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 552XV UT WOS:000274329400009 PM 20121573 ER PT J AU Scinicariello, F Kourtis, AP Nesheim, S Abramowsky, C Lee, FK AF Scinicariello, Franco Kourtis, Athena P. Nesheim, Steven Abramowsky, Carlos Lee, Francis K. TI Limited Evolution of Human Immunodeficiency Virus Type 1 in the Thymus of a Perinatally Infected Child SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CD8(+) T-LYMPHOCYTES; SCID-HU MICE; IN-VIVO; HIV-1 INFECTION; ANTIRETROVIRAL THERAPY; ENV GENES; CELLS; INFANTS; BLOOD; AIDS AB Background. Involvement of the thymus during human immunodeficiency virus (HIV) infection may impair production of naive lymphocytes leading to more rapid depletion, but the characteristics of primary strains in the thymus are not well studied because of the unavailability of tissue in living individuals. Methods. We studied the characteristics of HIV type 1 (HIV-1) in a 5-year old perinatally infected child with thymitis and compared the genomic sequences of the HIV-1 C2-V5 region of the env gene in the thymic tissue and peripheral blood. Results. The thymus harbored predominantly viral sequences close to the founder HIV-1 variant that circulated in the blood at 2 and 3 months of age, whereas the peripheral blood virus at 5 years of age had evolved extensively. Viral sequences from circulating CD8(+) T cells at 5 years of age phylogenetically clustered with those from the thymic tissue. Conclusions. These results indicate the existence of a distinct thymic viral reservoir and suggest that circulating CD8(+) T cells were infected in the thymus, presumably at the CD4(+)CD8(+) thymocyte stage. They also demonstrate that not all thymic HIV infections will necessarily lead to severe thymic dysfunction. The characteristics of the virus strain seeding the thymus may dictate the rate of disease progression. C1 [Scinicariello, Franco; Kourtis, Athena P.; Nesheim, Steven; Lee, Francis K.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30303 USA. [Abramowsky, Carlos] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA. RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, MS-K34,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM apk3@cdc.gov NR 48 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 1 PY 2010 VL 50 IS 5 BP 726 EP 732 DI 10.1086/650453 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 552XV UT WOS:000274329400012 PM 20100091 ER PT J AU Yang, G Benson, R Pelish, T Brown, E Winchell, JM Fields, B AF Yang, G. Benson, R. Pelish, T. Brown, E. Winchell, J. M. Fields, B. TI Dual detection of Legionella pneumophila and Legionella species by real-time PCR targeting the 23S-5S rRNA gene spacer region SO CLINICAL MICROBIOLOGY AND INFECTION LA English DT Article DE 23S-5S; Legionella pneumophila; Legionella species; Legionnaires' disease; real-time PCR ID POLYMERASE-CHAIN-REACTION; LEGIONNAIRES-DISEASE; SERUM SAMPLES; HYBRIDIZATION METHOD; CLINICAL SPECIMENS; URINE SAMPLES; PNEUMONIA; IDENTIFICATION; DNA; INFECTION AB P>Although the majority of cases of Legionnaires' disease (LD) are caused by Legionella pneumophila, an increasing number of other Legionella species have been reported to cause human disease. There are no clinical presentations unique to LD and hence accurate laboratory tests are required for early diagnosis. Therefore, we designed a real-time PCR assay that targets the 23S-5S rRNA intergenic spacer region (23S-5S PCR) and allows for detection of all Legionella species and discrimination of L. pneumophila from other Legionella species. In total, 271 isolates representing 50 Legionella species were tested and the assay was validated using 39 culture-positive and 110 culture-negative patient specimens collected between 1989 and 2006. PCR-positive results were obtained with all 39 culture-positive samples (100% sensitivity). Specimens that tested positive according to 23S-5S PCR, but were culture-negative, were further analysed by DNA sequencing of the amplicon or the macrophage infectivity potentiator (mip) gene. In addition to L. pneumophila, Legionella longbeachae, Legionella cincinnatiensis and Legionella micdadei were identified in the specimens. The assay showed a 7-log dynamic range displaying a sensitivity of 7.5 CFU/mL or three genome equivalents per reaction. Sixty-one specimens containing viruses or bacteria other than Legionellae were negative according to 23S-5S PCR, demonstrating its specificity. Use of this assay should contribute to the earlier detection of respiratory disease caused by Legionella species, as well as to increased rates of detection. C1 [Yang, G.; Benson, R.; Pelish, T.; Brown, E.; Winchell, J. M.; Fields, B.] Ctr Dis Control & Prevent, Div Bacterial Dis, Resp Dis Branch, Atlanta, GA 30333 USA. RP Yang, G (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, Resp Dis Branch, 1600 Clifton Rd NE,MS G-03, Atlanta, GA 30333 USA. EM fni8@cdc.gov NR 33 TC 17 Z9 18 U1 2 U2 5 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1198-743X J9 CLIN MICROBIOL INFEC JI Clin. Microbiol. Infect. PD MAR PY 2010 VL 16 IS 3 BP 255 EP 261 DI 10.1111/j.1469-0691.2009.02766.x PG 7 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 554AJ UT WOS:000274407600008 PM 19438641 ER PT J AU Bronstein, AC Spyker, DA Worthen, K Espino, JU Stinn, JF Lee, BA Savel, T AF Bronstein, A. C. Spyker, D. A. Worthen, K. Espino, J. U. Stinn, J. F. Lee, B. A. Savel, T. TI National Poison Data System: Enhancing Public Health Surveillance by Delivering Poison Center Call Information Using Secure Web Services SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract C1 [Bronstein, A. C.] Denver Hlth Univ Colorado, Sch Med, Rocky Mt Poison Ctr, Denver, CO USA. [Spyker, D. A.] Univ Hlth Sci, Dept Internal Med, Uniform Serv, Bethesda, MD USA. [Worthen, K.] CIBER Inc, Washington, DC USA. [Espino, J. U.] Univ Pittsburgh, Real Time Outbreak & Dis Surveillance Lab, Pittsburgh, PA USA. [Stinn, J. F.; Lee, B. A.] Deloitte Consulting LLP, Atlanta, GA USA. [Savel, T.] US Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD MAR PY 2010 VL 48 IS 3 MA 91 BP 261 EP 261 PG 1 WC Toxicology SC Toxicology GA 584OO UT WOS:000276762200106 ER PT J AU Hartman, AL Towner, JS Nichol, ST AF Hartman, Amy L. Towner, Jonathan S. Nichol, Stuart T. TI Ebola and Marburg Hemorrhagic Fever SO CLINICS IN LABORATORY MEDICINE LA English DT Article DE Ebola; Marburg; Filovirus; Hemorrhagic fever ID VIRUS-LIKE PARTICLES; NONHUMAN-PRIMATES; DENDRITIC CELLS; POSTEXPOSURE TREATMENT; ENDOTHELIAL-CELLS; RHESUS-MONKEYS; TISSUE FACTOR; GUINEA-PIGS; IN-VITRO; INFECTION AB Ebola and Marburg viruses cause a severe viral hemorrhagic fever disease mainly in Sub-Saharan Africa. Although outbreaks are sporadic, there is the potential for filoviruses to spread to other continents unintentionally because of air travel or intentionally because of bioterrorism. This article discusses the natural history, epidemiology, and clinical presentation of patients infected with Ebola and Marburg viruses. Clinicians in the United States should be aware of the symptoms of these viral infections in humans and know the appropriate procedures for contacting local, state, and national reference laboratories in the event of a suspected case of filoviral hemorrhagic fever. C1 [Hartman, Amy L.] Univ Pittsburgh, Reg Biocontainment Lab, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. [Hartman, Amy L.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA. [Towner, Jonathan S.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. RP Hartman, AL (reprint author), Univ Pittsburgh, Reg Biocontainment Lab, Ctr Vaccine Res, 9015 Biomed Sci Tower 3,3501 5th Ave, Pittsburgh, PA 15261 USA. EM hartman2@pitt.edu OI Hartman, Amy/0000-0002-0857-2973 NR 62 TC 66 Z9 69 U1 6 U2 68 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-2712 J9 CLIN LAB MED JI Clin. Lab. Med. PD MAR PY 2010 VL 30 IS 1 BP 161 EP + DI 10.1016/j.cll.2009.12.001 PG 19 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 618MA UT WOS:000279358200008 PM 20513546 ER PT J AU Powers, AM AF Powers, Ann M. TI Chikungunya SO CLINICS IN LABORATORY MEDICINE LA English DT Article DE Chikungunya virus; Alphavirus; Mosquito-borne arbovirus ID ACUTE FLACCID PARALYSIS; VIRUS-INFECTION; REUNION ISLAND; INDIAN-OCEAN; ANTIGENIC RELATIONSHIPS; LABORATORY FEATURES; ADULT PATIENTS; RISK-FACTORS; SOUTH-INDIA; DISEASE AB Chikungunya virus is a zoonotic, vector-borne pathogen that has been responsible for numerous outbreaks of febrile arthralgia since its discovery in the early 1950s. In the past decade, the virus has re-emerged more frequently, causing massive epidemics that have moved from Africa throughout the Indian Ocean to India and Southeast Asia. A discussion of the virus, its epidemiology, diagnostic criteria, and immunity are presented in this article. C1 Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP Powers, AM (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM apowers@cdc.gov NR 65 TC 36 Z9 36 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-2712 EI 1557-9832 J9 CLIN LAB MED JI Clin. Lab. Med. PD MAR PY 2010 VL 30 IS 1 BP 209 EP + DI 10.1016/j.cll.2009.10.003 PG 12 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 618MA UT WOS:000279358200010 PM 20513548 ER PT J AU Siegel, PD Fowler, JF Storrs, FJ Sasseville, D Pratt, M Bledsoe, TA Law, BF Beezhold, D Zug, K Fowler, LM AF Siegel, Paul D. Fowler, Joseph F., Jr. Storrs, Frances J. Sasseville, Denis Pratt, Melanie Bledsoe, Toni A. Law, Brandon F. Beezhold, Donald Zug, Kathryn Fowler, Lynn M. TI Allergen Content of Patient Problem and Nonproblem Gloves: Relationship to Allergen-Specific Patch-Test Findings SO DERMATITIS LA English DT Article ID HEALTH-CARE WORKERS; CONTACT-DERMATITIS; LATEX ALLERGY; IV ALLERGY; SENSITIZATION; ELICITATION; CHEMICALS AB Background: Identification of putative contact allergen and source material is often done by a combination of patch testing and manufacturer-supplied product information. The accuracy of the identification of allergen-source material and level of allergen in that allergen-source material is not known. Objective: The objectives of the study were to survey the chemical allergen content of glove allergic contact dermatitis (ACD) patient-identified problem and nonproblem gloves and to evaluate the ability of the patient to discriminate between problem and nonproblem gloves. Methods: Gloves from patch-tested rubber allergen-positive ACD patients were analyzed for species and amount of rubber allergen. Results: Approximately half the subjects were able to correctly identify their problem and nonproblem gloves. Correct association of a glove with ACD was directly related to patch-test reaction severity and inversely related to the number of glove brands being used by the patient. Of note, thiurams were not detected in any of the gloves examined. Conclusions: Although patch testing is invaluable in identifying individual allergen sensitivities, the identification of the ACD-causative specific chemical allergen and source material remains problematic. All glove brands used within days prior to and during an ACD episode should be considered potential sources of the contact allergen. C1 [Siegel, Paul D.] NIOSH, CDC, Morgantown, WV USA. Univ Louisville, Louisville, KY 40292 USA. Oregon Hlth & Sci Univ, Portland, OR USA. McGill Univ, Ctr Hlth, Montreal, PQ, Canada. Ottawa Hosp, Ottawa, ON, Canada. Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. RP Siegel, PD (reprint author), NIOSH, CDC, Morgantown, WV USA. FU National Institute for Occupational Safety and Health National Research Agenda Intramural FX Funded by a National Institute for Occupational Safety and Health National Research Agenda Intramural Grant.; Funds for this project were provided by a National Institute for Occupational Safety and Health National Research Agenda Intramural Grant. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 19 TC 2 Z9 2 U1 1 U2 2 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1710-3568 J9 DERMATITIS JI Dermatitis PD MAR-APR PY 2010 VL 21 IS 2 BP 77 EP 83 DI 10.2310/6620.2010.09088 PG 7 WC Dermatology SC Dermatology GA 579NA UT WOS:000276376500002 PM 20233545 ER PT J AU Cowie, CC Rust, KF Byrd-Holt, DD Gregg, EW Ford, ES Geiss, LS Bainbridge, KE Fradkin, JE AF Cowie, Catherine C. Rust, Keith F. Byrd-Holt, Danita D. Gregg, Edward W. Ford, Earl S. Geiss, Linda S. Bainbridge, Kathleen E. Fradkin, Judith E. TI Prevalence of Diabetes and High Risk for Diabetes Using A1C Criteria in the US Population in 1988-2006 SO DIABETES CARE LA English DT Article AB OBJECTIVE - We examined prevalences of previously diagnosed diabetes and undiagnosed diabetes and high risk for diabetes using recently Suggested A1C criteria in the U.S. during 2003-2006. We compared these prevalences to those in earlier surveys and those using glucose criteria. RESEARCH DESIGN AND METHODS - in 2003-2006, the National Health and Nutrition Examination Survey included a probability sample of 14,611 individuals aged >= 12 years. Participants were classified on glycemic status by interview for diagnosed diabetes and by A1C, fasting, and 2-h glucose challenge values measured in subsamples. RESULTS - Using A1C criteria, the crude prevalence of total diabetes in adults aged >= 20 years was 9.6% (20.4 million), of which 19.0% was undiagnosed (7.8% diagnosed, 1.8% undiagnosed Using A1C >= 6.5%). Another 3.5% of adults (7.4 million) were at high risk for diabetes (A1C 6.0 to <6.5%). Prevalences were disproportionately high in the elderly. Age-/sex-standardized prevalence was more than two Limes higher in non-Hispanic blacks and Mexican Americans versus non-Hispanic whites for diagnosed, undiagnosed, and total diabetes (P < 0.003); standardized prevalence at high risk for diabetes was more than two times higher in non-Hispanic blacks Versus non-Hispanic whites and Mexican Americans (P < 0.00001. Since 1988-1994, diagnosed diabetes generally increased, while the percent of diabetes that was undiagnosed and the percent at high risk of diabetes generally decreased. Using A1C Criteria, prevalences of undiagnosed diabetes and high risk of diabetes were one-third that and one-tenth that, respectively, using glucose criteria. CONCLUSIONS - Although A1C detects much lower prevalences than glucose criteria, hyperglycemic conditions remain high in the U.S., and elderly and minority groups are disproportionately affected. C1 [Cowie, Catherine C.; Fradkin, Judith E.] NIDDK, NIH, Bethesda, MD 20892 USA. [Rust, Keith F.] WESTAT Corp, Rockville, MD 20850 USA. [Byrd-Holt, Danita D.; Bainbridge, Kathleen E.] Social & Sci Syst, Silver Spring, MD USA. [Gregg, Edward W.; Geiss, Linda S.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Ford, Earl S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA. RP Cowie, CC (reprint author), NIDDK, NIH, Bethesda, MD 20892 USA. EM cowie@nih.gov NR 14 TC 290 Z9 295 U1 0 U2 7 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD MAR PY 2010 VL 33 IS 3 BP 562 EP 568 DI 10.2337/dc09-1524 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 568YO UT WOS:000275562700021 PM 20067953 ER PT J AU Metzger, BE Gabbe, SG Persson, B Buchanan, TA Catalano, PM Damm, P Dyer, AR de Leiva, A Hod, M Kitzmiller, JL Lowe, LP McIntyre, HD Oats, JJN Omori, Y Schmidt, MI Balaji, V Callaghan, WM Chen, R Conway, D Corcoy, R Coustan, DR Dabelea, D Fagen, C Feig, DS Ferrara, A Geil, P Hadden, DR Hillier, TA Hiramatsu, Y Houde, G Inturissi, M Jang, HC Jovanovic, L Kautsky-Willer, A Kirkman, MS Kjos, SL Landon, MB Lapolla, A Lowe, J Mathiesen, HER Mello, G Meltzer, SJ Moore, TR Nolan, CJ Ovesen, P Pettitt, P Reader, DM Rowan, JA Sacks, DA Schaefer-Graf, U Seshiah, V Simmons, D Sugiyama, T Trimble, ER Varma, S Yang, HX Yasuhi, I AF Metzger, Boyd E. Gabbe, Steven G. Persson, Bengt Buchanan, Thomas A. Catalano, Patrick M. Damm, Peter Dyer, Alan R. de Leiva, Alberto Hod, Moshe Kitzmiller, John L. Lowe, Lynn P. McIntyre, H. David Oats, Jeremy J. N. Omori, Yasue Schmidt, Maria Ines Balaji, Vijayam Callaghan, William M. Chen, Rony Conway, Deborah Corcoy, Rosa Coustan, Donald R. Dabelea, Dana Fagen, Cathy Feig, Denice S. Ferrara, Assiamira Geil, Patti Hadden, David R. Hillier, Teresa A. Hiramatsu, Yuji Houde, Ghislaine Inturissi, Maribeth Jang, Hak C Jovanovic, Lois Kautsky-Willer, Alexandra Kirkman, M. Sue Kjos, Siri L. Landon, Mark B. Lapolla, Annunziata Lowe, Julia Mathiesen, H. Elisabeth R. Mello, Giorgio Meltzer, Sara J. Moore, Thomas R. Nolan, Christopher J. Ovesen, Per Pettitt, David Reader, Diane M. Rowan, Janet A. Sacks, David A. Schaefer-Graf, Ute Seshiah, Veeraswamy Simmons, David Sugiyama, Takashi Trimble, Elisabeth R. Varma, Surendra Yang, Huixia Yasuhi, Ichiro CA Int Assoc Diabet Pregnancy TI International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy SO DIABETES CARE LA English DT Review ID GLUCOSE-TOLERANCE TEST; OUTCOME HAPO; CARBOHYDRATE INTOLERANCE; WORKSHOP-CONFERENCE; UNITED-STATES; PIMA-INDIANS; BIRTH-WEIGHT; MELLITUS; WOMEN; OBESITY C1 [Metzger, Boyd E.; Dyer, Alan R.; Lowe, Lynn P.] Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA. [Gabbe, Steven G.] Ohio State Univ, Columbus, OH 43210 USA. [Persson, Bengt] Karolinska Inst, S-10401 Stockholm, Sweden. [Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90089 USA. [Catalano, Patrick M.] Case Western Reserve Univ, MetroHlth Med Ctr, Cleveland, OH 44106 USA. [Damm, Peter; Mathiesen, H. Elisabeth R.] Univ Copenhagen, Rigshosp, DK-1168 Copenhagen, Denmark. [de Leiva, Alberto] Univ Autonoma Barcelona, Hosp St Paul, Barcelona, Spain. [Hod, Moshe; Chen, Rony] Tel Aviv Univ, Helen Schneider Hosp Women, Rabin Med Ctr, Sackler Fac Med, IL-69978 Tel Aviv, Israel. [Kitzmiller, John L.] Santa Clara Valley Med Ctr, San Jose, CA USA. [McIntyre, H. David] Univ Queensland, Mater Misericordiae Mothers Hosp, St Lucia, Qld 4067, Australia. [Oats, Jeremy J. N.] Univ Melbourne, Royal Womens Hosp, Parkville, Vic 3052, Australia. [Omori, Yasue] Tokyo Womens Med Univ, Tokyo, Japan. [Schmidt, Maria Ines] Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, Brazil. [Balaji, Vijayam; Seshiah, Veeraswamy] Dr Balaji Diabet Care Ctr, Dr Seshiah Diabet Res Inst, Madras, Tamil Nadu, India. [Callaghan, William M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Conway, Deborah] Univ Texas San Antonio, San Antonio, TX USA. [Corcoy, Rosa] Hosp Santa Creu & Sant Pau, Inst Salud Carlos III, Barcelona, Spain. [Coustan, Donald R.] Brown Univ, Warren Alpert Med Sch, Women & Infants Hosp Rhode Isl, Providence, RI 02912 USA. [Dabelea, Dana] Univ Colorado, Colorado Sch Publ Hlth, Denver, CO USA. [Fagen, Cathy] Miller Childrens Hosp, Long Beach Mem Ctr, Long Beach, CA USA. [Feig, Denice S.] Univ Toronto, Div Endocrinol, Toronto, ON, Canada. [Ferrara, Assiamira] Kaiser Permanente Northern Calif, Oakland, CA USA. [Geil, Patti] Geil Nutr Commun, Lexington, KY USA. [Hadden, David R.] Royal Jubilee Matern Hosp, Belfast, Antrim, North Ireland. [Hillier, Teresa A.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Hiramatsu, Yuji] Okayama Univ, Grad Sch Med, Okayama, Japan. [Houde, Ghislaine] Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada. [Inturissi, Maribeth] Univ Calif San Francisco, Calif Pacific Med Ctr, San Francisco, CA 94143 USA. [Jang, Hak C] Seoul Natl Univ, Bundang Hosp, Seoul 151, South Korea. [Jovanovic, Lois] Univ Calif Santa Barbara, Keck Sch Med, Santa Barbara, CA USA. [Kautsky-Willer, Alexandra] Med Univ Vienna, Vienna, Austria. [Kirkman, M. Sue] Amer Diabet Assoc, Alexandria, VA USA. [Kjos, Siri L.] Harbor UCLA Med Ctr, Torrance, CA USA. [Landon, Mark B.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA. [Lapolla, Annunziata] Univ Padua, I-35100 Padua, Italy. [Lowe, Julia] Univ Toronto, Toronto, ON, Canada. [Mello, Giorgio] Univ Florence, I-50121 Florence, Italy. [Meltzer, Sara J.] McGill Univ, Sch Med, Montreal, PQ H3A 2T5, Canada. [Moore, Thomas R.] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA. [Nolan, Christopher J.] Australian Natl Univ, Med Sch, Canberra, ACT, Australia. [Ovesen, Per] Aarhus Univ Hosp, Aarhus, Denmark. [Pettitt, David] Sansum Diabet Res Inst, Santa Barbara, CA USA. [Reader, Diane M.] Int Diabet Ctr, Minneapolis, MN USA. [Rowan, Janet A.] Auckland City Hosp, Auckland, New Zealand. [Sacks, David A.] Southern Calif Permanente Med Grp, San Diego, CA USA. [Schaefer-Graf, Ute] St Josef Hosp, Bochum, Germany. [Simmons, David] Univ Melbourne, Cambridge Univ Hosp NHS Fdn Trust, Parkville, Vic 3052, Australia. [Sugiyama, Takashi] Mie Univ, Grad Sch Med, Tsu, Mie, Japan. [Trimble, Elisabeth R.] Queens Univ Belfast, Belfast BT7 1NN, Antrim, North Ireland. [Varma, Surendra] TTUHSC Sch Med, Lubbock, TX USA. [Yang, Huixia] Peking Univ, Hosp 1, Beijing, Peoples R China. [Yasuhi, Ichiro] NHO Nagasaki Med Ctr, Nagasaki, Japan. RP Metzger, BE (reprint author), Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA. EM bem@northwestern.edu RI Jang, Hak Chul/D-9637-2012; Iats, Inct/K-2300-2013; Nolan, Christopher/B-2026-2008; Feig, Denice/C-4606-2015; OI McIntyre, Harold/0000-0001-8819-5794; Simmons, David/0000-0003-0560-0761; Ferrara, Assiamira/0000-0002-7505-4826 FU National Institute of Child Health and Human Development; National Institute of Diabetes, Digestive and Kidney Diseases [R01-HD-34242, R01-HD-34243]; American Diabetes Association; Veralight FX The HAPO study was funded by National Institute of Child Health and Human Development and the National Institute of Diabetes, Digestive and Kidney Diseases Grants R01-HD-34242 and R01-HD-34243 as well as a grant from the American Diabetes Association.; T.H. received research support (funds paid to Kaiser Permanente) to participate at one site in a multicenter trial of the noninvasive Scout device in the past 12 months and has received research support from Veralight. NR 57 TC 1025 Z9 1073 U1 5 U2 55 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD MAR PY 2010 VL 33 IS 3 BP 676 EP 682 DI 10.2337/dc09-1848 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 568YO UT WOS:000275562700043 ER PT J AU Zhang, P Zhang, XZ Brown, J Vistisen, D Sicree, R Shaw, J Nichols, G AF Zhang, Ping Zhang, Xinzhi Brown, Jonathan Vistisen, Dorte Sicree, Richard Shaw, Jonathan Nichols, Gregory TI Global healthcare expenditure on diabetes for 2010 and 2030 SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Article DE Diabetes; Health expenditure; Economic burden ID MELLITUS; IMPACT; COST AB Aims: To estimate the global health expenditure on diabetes among people aged 20-79 years for the years 2010 and 2030. Methods: Country-by-country expenditures for 193 countries, expressed in United States Dollars (USD) and in International Dollars (ID), were estimated based on the country's age-sex specific diabetes prevalence and population estimates, per capita health expenditures, and health expenditure ratios per person with and without diabetes. Diabetes prevalence was estimated from studies in 91 countries. Population estimates and health expenditures were from the United Nations and the World Health Organization. The health expenditure ratios were estimated based on utilization and cost data of a large health plan in the U.S. Diabetes expenditures for the year 2030 were projected by considering future changes in demographics and urbanization. Results: The global health expenditure on diabetes is expected to total at least USD 376 billion or ID 418 billion in 2010 and USD 490 billion or ID 561 billion in 2030. Globally, 12% of the health expenditures and USD 1330 (ID 1478) per person are anticipated to be spent on diabetes in 2010. The expenditure varies by region, age group, gender, and country's income level. Conclusions: Diabetes imposes an increasing economic burden on national health care systems worldwide. More prevention efforts are needed to reduce this burden. Meanwhile, the very low expenditures per capita in poor countries indicate that more resources are required to provide basic diabetes care in such settings. Published by Elsevier Ireland Ltd. C1 [Zhang, Ping; Zhang, Xinzhi] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30333 USA. [Brown, Jonathan; Nichols, Gregory] Kaiser Permanente, Ctr Hlth Res, Portland, OR USA. [Vistisen, Dorte] Steno Diabet Ctr NS, DK-2820 Gentofte, Denmark. [Sicree, Richard; Shaw, Jonathan] Baker IDI Heart & Diabet Inst, Caulfield, Vic 3162, Australia. RP Zhang, P (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Mailstop K-10,4770 Buford Highway NE, Atlanta, GA 30333 USA. EM Pzhang@cdc.gov RI Shaw, Jonathan/E-7388-2010 OI Shaw, Jonathan/0000-0002-6187-2203 FU Medical Research Council [G0501184] NR 15 TC 352 Z9 359 U1 4 U2 49 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD MAR PY 2010 VL 87 IS 3 BP 293 EP 301 DI 10.1016/j.diabres.2010.01.026 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 580KH UT WOS:000276446600001 PM 20171754 ER PT J AU Fullerton, CS Reissman, DB Gray, C Flynn, BW Ursano, RJ AF Fullerton, Carol S. Reissman, Dori B. Gray, Christine Flynn, Brian W. Ursano, Robert J. TI Earthquake Response and Psychosocial Health Outcomes: Applying Lessons From Integrating Systems of Care and Recovery to Haiti SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Editorial Material ID POSTTRAUMATIC-STRESS C1 [Fullerton, Carol S.; Reissman, Dori B.; Gray, Christine; Flynn, Brian W.; Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Reissman, Dori B.] US PHS, Rockville, MD USA. [Reissman, Dori B.] NIOSH, Ctr Dis Control & Prevent, Atlanta, GA USA. RP Fullerton, CS (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM cfullert@erols.com NR 19 TC 5 Z9 5 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD MAR PY 2010 VL 4 IS 1 BP 15 EP 17 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 583QE UT WOS:000276692700005 PM 20389189 ER PT J AU Leeb, K Chrysler, D Goodman, RA AF Leeb, Karen Chrysler, Denise Goodman, Richard A. TI The Social Distancing Law Project Template: A Method for Jurisdictions to Assess Understanding of Relevant Legal Authorities SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE social distancing law project; template; self-assessment; legal authorities; influenza; pandemic ID HEALTH; PREPAREDNESS; THREATS AB Methods: The Centers for Disease Control and Prevention and the Association of State and Territorial Health Officials selected 17 state and large local jurisdictions on the basis of their proximity to federal quarantine stations and collaborated with their state health department legal counsel to conduct formulaic self-assessments of social distancing legal authorities, create tables of authority, and test and report on the laws' sufficiency (ie, scope and breadth). Select jurisdictions also held tabletop exercises to test public health and law enforcement officials' understanding and implementation of pertinent laws. This report presents findings for Michigan, which completed the legal assessment and tabletop exercise and made several recommendations for change as a result. Results: Officials in Michigan concluded that there are sufficient existing laws to support social distancing measures but that a spectrum of questions remained regarding implementation of these legal authorities. Based on the findings of this assessment, Michigan initiated actions to address areas for improvement. Conclusions: The results of this project highlighted the value of integrally involving the state health department's legal counsel-those most familiar with and who advise on a given state's public health laws-in the periodic identification, assessment, and testing of the state's legal authorities for social distancing and other measures used in response to many public health emergencies. ( Disaster Med Public Health Preparedness. 2010; 4:74-80) C1 [Leeb, Karen; Goodman, Richard A.] Ctr Dis Control & Prevent, Publ Hlth Law Program, Off Strategy & Innovat, Atlanta, GA 30333 USA. RP Goodman, RA (reprint author), Ctr Dis Control & Prevent, Publ Hlth Law Program, Off Strategy & Innovat, Mailstop D-30,1600 Clifton Rd, Atlanta, GA 30333 USA. EM rag4@cdc.gov NR 16 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD MAR PY 2010 VL 4 IS 1 BP 74 EP 80 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 583QE UT WOS:000276692700015 PM 20389199 ER PT J AU Keim, ME AF Keim, Mark E. TI Sea-Level-Rise Disaster in Micronesia: Sentinel Event for Climate Change? SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE Climate change; natural disasters; sea-level rise; Pacific islands; vulnerable population; Small Island Developing States AB Objectives: To describe the impact of an acute-onset sea-level-rise disaster in 2 coral atoll populations and to generate hypotheses for further investigation of the association between climate change and public health. Methods: Households of Lukunoch and Oneop islands, Micronesia, were assessed for demographics, asset damage, food availability, water quantity and quality, hygiene and sanitation, and health status. Every fourth household on Lukunoch was randomly selected (n=40). All Oneop households were surveyed (n=72). Heads of each household were interviewed in the local language using a standard survey tool. Prevalence data were analyzed, and 95% confidence intervals were calculated. Results: A total of 112 total households were respondents representing 974 inhabitants. On Lukunoch, roughly half of all households surveyed reported at least a partial loss of their primary dietary staple and source of calories ( taro and breadfruit). Six (15%) of 40 Lukunoch households surveyed ( 95% CI, 6%-30%) reported a complete loss of taro and four (10%) of the 40 households ( 95% CI, 3%-24%) reported a complete loss of breadfruit. On Oneop, nearly all households reported at least a partial loss of these same food staples. Twenty four (31%) of all 76 Oneop households reported a complete loss of taro and another 24 ( 31%) households reported a complete loss of breadfruit. One third of all households surveyed reported a complete loss. On Lukunoch 11(28%) of 40 households,( 95% CI, 15%-43%) reported damage from salination, but none were damaged to the point of a complete loss. Forty-nine (64%) of 76 Oneop households reported salination and five (6%) reported complete loss of their well. Conclusion: On March 5, 2007, an acute-onset, sea-level-rise event resulting in coastal erosion, shoreline inundation, and saltwater intrusion occurred in two coral atoll islands of Micronesia. The findings of this study suggest that highly vulnerable populations of both islands experienced disastrous losses involving crop productivity and freshwater sources. These findings reveal the need for effective public health research and sustainable interventions that will monitor and shape the health of small island populations predicted to be at high risk for adverse health effects due to climate change. ( Disaster Med Public Health Preparedness. 2010; 4: 81-87) C1 Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA. RP Keim, ME (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, 4770 Buford Hwy,MS F29, Atlanta, GA 30341 USA. NR 14 TC 4 Z9 4 U1 1 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD MAR PY 2010 VL 4 IS 1 BP 81 EP 87 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 583QE UT WOS:000276692700016 PM 20389200 ER PT J AU Hayden, MH Uejio, CK Walker, K Ramberg, F Moreno, R Rosales, C Gameros, M Mearns, LO Zielinski-Gutierrez, E Janes, CR AF Hayden, Mary H. Uejio, Christopher K. Walker, Kathleen Ramberg, Frank Moreno, Rafael Rosales, Cecilia Gameros, Mercedes Mearns, Linda O. Zielinski-Gutierrez, Emily Janes, Craig R. TI Microclimate and Human Factors in the Divergent Ecology of Aedes aegypti along the Arizona, US/Sonora, MX Border SO ECOHEALTH LA English DT Article DE Aedes aegypti; vegetation; microclimate; human ecology; US-Mexico border; dengue fever ID DENGUE HEMORRHAGIC-FEVER; PUERTO-RICO; POPULATION-DYNAMICS; CULICIDAE; DIPTERA; SURVIVAL; MEXICO; TRANSMISSION; TEMPERATURE; ABUNDANCE AB This study examined the association of human and environmental factors with the presence of Aedes aegypti, the vector for dengue fever and yellow fever viruses, in a desert region in the southwest United States and northwest Mexico. Sixty-eight sites were longitudinally surveyed along the United States-Mexico border in Tucson, AZ, Nogales, AZ, and Nogales, Sonora during a 3-year period. Aedes aegypti presence or absence at each site was measured three times per year using standard oviposition traps. Maximum and minimum temperature and relative humidity were measured hourly at each site. Field inventories were conducted to measure human housing factors potentially affecting mosquito presence, such as the use of air-conditioning and evaporative coolers, outdoor vegetation cover, and access to piped water. The results showed that Ae. aegypti presence was highly variable across space and time. Aedes aegypti presence was positively associated with highly vegetated areas. Other significant variables included microclimatic differences and access to piped water. This study demonstrates the importance of microclimate and human factors in predicting Ae. aegypti distribution in an arid environment. C1 [Hayden, Mary H.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA. [Uejio, Christopher K.] Univ Wisconsin, Nelson Inst Ctr Sustainabil & Global Environm, Madison, WI USA. [Walker, Kathleen; Ramberg, Frank] Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA. [Moreno, Rafael] Univ Colorado, Dept Geog & Environm Sci, Denver, CO 80202 USA. [Rosales, Cecilia; Gameros, Mercedes] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA. [Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Janes, Craig R.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada. RP Hayden, MH (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM mhayden@ucar.edu FU National Science Foundation; Office of Global Programs, U.S. Department of Commerce [NA16GP2615]; NOAA's Office of Global Programs FX The National Center for Atmospheric Research is sponsored by the National Science Foundation. This manuscript was prepared by Mary H. Hayden and co-authors under award NA16GP2615 from the Office of Global Programs, U.S. Department of Commerce. The statements, finding, conclusions, and recommendations are those of the author(s) and do not necessarily reflect the views of the National Oceanic and Atmospheric Administration or the U.S. Department of Commerce. The authors would like to thank the NOAA's Office of Global Programs for funding support. We greatly appreciate the comments and suggestions provided by the anonymous reviewers. We would also like to thank Duane Gubler, Gary Clark, Philippe Waterinckx, Deborah Thomas, Craig Levy, Andrew Comrie, and RosaElena Cuevas for field support without which this research would not have been possible. All of the household study participants were unfailingly gracious in providing access to their property throughout the duration of the study. NR 58 TC 22 Z9 22 U1 7 U2 26 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-9202 J9 ECOHEALTH JI EcoHealth PD MAR PY 2010 VL 7 IS 1 BP 64 EP 77 DI 10.1007/s10393-010-0288-z PG 14 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 634PP UT WOS:000280595700008 PM 20232228 ER PT J AU Reisenman, CE Lawrence, G Guerenstein, PG Gregory, T Dotson, E Hildebrand, JG AF Reisenman, Carolina E. Lawrence, Gena Guerenstein, Pablo G. Gregory, Teresa Dotson, Ellen Hildebrand, John G. TI Infection of Kissing Bugs with Trypanosoma cruzi, Tucson, Arizona, USA SO EMERGING INFECTIOUS DISEASES LA English DT Article ID POLYMERASE-CHAIN-REACTION; CHAGAS-DISEASE; UNITED-STATES; AMERICAN TRYPANOSOMIASIS; AUTOCHTHONOUS TRANSMISSION; ARGENTINA; TEXAS; AMPLIFICATION; DIAGNOSIS; VECTORS AB Triatomine insects (Hemiptera: Reduviidae), commonly known as kissing bugs, are a potential health problem in the southwestern United States as possible vectors of Trypanosoma cruzi, the causative agent of Chagas disease. Although this disease has been traditionally restricted to Latin America, a small number of vector-transmitted autochthonous US cases have been reported. Because triatomine bugs and infected mammalian reservoirs are plentiful in southern Arizona, we collected triatomines inside or around human houses in Tucson and analyzed the insects using molecular techniques to determine whether they were infected with T cruzi. We found that 41.5% of collected bugs (n = 164) were infected with T cruzi, and that 63% of the collection sites (n = 22) yielded >= 1 infected specimens. Although many factors may contribute to the lack of reported cases in Arizona, these results indicate that the risk for infection in this region may be higher than previously thought. C1 [Reisenman, Carolina E.] Univ Arizona, Dept Neurosci, Coll Sci, Tucson, AZ 85721 USA. [Lawrence, Gena; Dotson, Ellen] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Reisenman, CE (reprint author), Univ Arizona, Dept Neurosci, Coll Sci, POB 210077, Tucson, AZ 85721 USA. EM carolina@neurobio.arizona.edu FU Arizona Biomedical Research Commission [0708] FX This work was supported by an Arizona Biomedical Research Commission grant no. 0708 (to J.G.H.). NR 40 TC 29 Z9 30 U1 0 U2 18 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2010 VL 16 IS 3 BP 400 EP 405 DI 10.3201/eid1603.090648 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 566WR UT WOS:000275404700005 PM 20202413 ER PT J AU Johnson, G Nemeth, N Hale, K Lindsey, N Panella, N Komar, N AF Johnson, Gregory Nemeth, Nicole Hale, Kristina Lindsey, Nicole Panella, Nicholas Komar, Nicholas TI Surveillance for West Nile Virus in American White Pelicans, Montana, USA. 2006-2007 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID EARLY WARNING SYSTEM; RAPID DETECTION; NORTH-AMERICA; COLORADO; DISEASE; MOSQUITOS; CULICIDAE; DIPTERA; COUNTY; IMPACT AB West Nile virus (WNV)-associated deaths of American white pelican (Pelecanus erythrorhynchos) chicks have been recognized at various nesting colonies in the United States since 2002. We evaluated American white pelican nesting colonies in Sheridan County, Montana, USA, for an association between WNV-positive pelican carcasses and human West Nile neuroinvasive disease. Persons in counties hosting affected colonies had a 5x higher risk for disease than those in counties with unaffected colonies. We also investigated WNV infection and blood meal source among mosquitoes and pelican tissue type for greatest WNV detection efficacy in carcasses. WNV-infected Culex tarsalis mosquitoes were detected and blood-engorged Cx. tarsalis contained pelican DNA. Viral loads and detection consistency among pelican tissues were greatest in feather pulp, brain, heart, and skin. Given the risks posed to wildlife and human health, coordinated efforts among wildlife and public health authorities to monitor these pelican colonies for WNV activity are potentially useful. C1 [Johnson, Gregory] Montana State Univ, Dept Anim & Range Sci, Bozeman, MT 59717 USA. [Nemeth, Nicole; Lindsey, Nicole; Panella, Nicholas; Komar, Nicholas] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Johnson, G (reprint author), Montana State Univ, Dept Anim & Range Sci, Rm 19,Linfield Hall, Bozeman, MT 59717 USA. EM gdj@montana.edu FU Montana Department of Health and Services; Montana Agricultural Experiment Station; Centers for Disease Control and Prevention FX This study was supported by the Montana Department of Health and Services, the Montana Agricultural Experiment Station, and the Centers for Disease Control and Prevention. NR 21 TC 12 Z9 12 U1 1 U2 9 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2010 VL 16 IS 3 BP 406 EP 411 DI 10.3201/eid1603.090559 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 566WR UT WOS:000275404700006 PM 20202414 ER PT J AU Adjemian, J Parks, S McElroy, K Campbell, J Eremeeva, ME Nicholson, WL McQuiston, J Taylor, J AF Adjemian, Jennifer Parks, Sharyn McElroy, Kristina Campbell, Jill Eremeeva, Marina E. Nicholson, William L. McQuiston, Jennifer Taylor, Jeffery TI Murine Typhus in Austin, Texas, USA, 2008 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID LOS-ANGELES-COUNTY; RICKETTSIA-FELIS; SOUTH TEXAS; OPOSSUMS; EPIDEMIOLOGY; ASSOCIATION; FLEAS AB In August 2008, Texas authorities and the Centers for Disease Control and Prevention investigated reports of increased numbers of febrile rash illnesses in Austin to confirm the causative agent as Rickettsia typhi, to assess the outbreak magnitude and illness severity, and to identify potential animal reservoirs and peridomestic factors that may have contributed to disease emergence. Thirty-three human cases of confirmed murine typhus were identified. Illness onset was reported from March to October. No patients died, but 23 (70%) were hospitalized. The case-patients clustered geographically in central Austin; 12 (36%) resided in a single ZIP code area. Specimens from wildlife and domestic animals near case-patient homes were assessed; 18% of cats, 44% of dogs, and 71% of opossums had antibodies reactive to R. typhi. No evidence of R. typhi was detected in the whole blood, tissue, or arthropod specimens tested. These findings suggest that an R. typhi cycle involving opossums and domestic animals may be present in Austin. C1 [Adjemian, Jennifer; Parks, Sharyn; McElroy, Kristina; Eremeeva, Marina E.; Nicholson, William L.; McQuiston, Jennifer] Ctr Dis Control & Prevent, Atlanta, GA USA. [Parks, Sharyn; Taylor, Jeffery] Texas Dept State Hlth Serv, Austin, TX USA. [Campbell, Jill] Austin Travis Cty Hlth Dept, Austin, TX USA. RP Adjemian, J (reprint author), Off Res & Evaluat, 320 1st St N,400 Bldg,Rm 3022, Washington, DC USA. EM jadjemian@bop.gov NR 18 TC 29 Z9 30 U1 1 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2010 VL 16 IS 3 BP 412 EP 417 DI 10.3201/eid1603.091028 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 566WR UT WOS:000275404700007 PM 20202415 ER EF