FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Xu, FJ Xing, J Moorman, AC Gordon, SC Rupp, LB Lu, M Spradling, PR Teshale, EH Boscarino, JA Vijayadeva, V Schmidt, MA AF Xu, Fujie Xing, Jian Moorman, Anne C. Gordon, Stuart C. Rupp, Loralee B. Lu, Mei Spradling, Philip R. Teshale, Eyasu H. Boscarino, Joseph A. Vijayadeva, Vinutha Schmidt, Mark A. TI FIB4 Score and Gender Predict the Incidence of Hepatocellular Carcinoma (HCC) among Patients with Chronic Hepatitis C Virus (HCV) Infection: Chronic Hepatitis Cohort Study (CHeCS) SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Xu, Fujie; Xing, Jian; Moorman, Anne C.; Spradling, Philip R.; Teshale, Eyasu H.] CDC, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Gordon, Stuart C.; Rupp, Loralee B.; Lu, Mei] Henry Ford Hlth Syst, Detroit, MI USA. [Boscarino, Joseph A.] Geisinger Hlth Syst, Danville, PA USA. [Vijayadeva, Vinutha] Kaiser Permanente Hawaii, Honolulu, HI USA. [Schmidt, Mark A.] Kaiser Permanente Northwest, Portland, OR USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1471 BP 905A EP 905A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804034 ER PT J AU Morgan, RL Blackburn, N Yartel, AK Des Jarlais, DC AF Morgan, Rebecca L. Blackburn, Natalie Yartel, Anthony K. Des Jarlais, Don C. TI Identifying the disease burden of hepatitis C virus (HCV) infection and non-injection drug use: a systematic review and meta-analysis of persons who use drugs but do not inject SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Morgan, Rebecca L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blackburn, Natalie] Oak Ridge Inst Sci & Educ, Atlanta, GA USA. [Yartel, Anthony K.] Ctr Dis Control & Prevent Fdn, Atlanta, GA USA. [Des Jarlais, Don C.] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1502 BP 921A EP 921A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804065 ER PT J AU Layden, JE Phillips, RO Sarfo, FS Mora, N Owusu, DO Kliethermes, S Owusu-Ofori, SP Forbi, J Opare-Sem, O Nelson, K Cooper, R AF Layden, Jennifer E. Phillips, Richard O. Sarfo, Fred S. Mora, Nallely Owusu, Dorcas O. Kliethermes, Stephanie Owusu-Ofori, Shirley P. Forbi, Joseph Opare-Sem, Ohene Nelson, Kenrad Cooper, Richard TI High Rates of HCV Active Infection in a Blood Bank Study in Ghana, West Africa SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Layden, Jennifer E.] Loyola Univ, Med Ctr, Maywood, IL 60153 USA. [Layden, Jennifer E.; Mora, Nallely; Kliethermes, Stephanie; Cooper, Richard] Loyola Univ Chicago, Maywood, IL USA. [Nelson, Kenrad] Johns Hopkins Univ, Baltimore, MD USA. [Forbi, Joseph] CDC, Atlanta, GA 30333 USA. [Phillips, Richard O.; Sarfo, Fred S.; Owusu, Dorcas O.; Owusu-Ofori, Shirley P.; Opare-Sem, Ohene] Komfo Anokye Teaching Hosp, Kumasi, Ghana. [Phillips, Richard O.; Sarfo, Fred S.; Opare-Sem, Ohene] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1512 BP 925A EP 926A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804075 ER PT J AU Layden, JE Phillips, RO Sarfo, FS Owusu, DO Mora, N Forbi, J Kliethermes, S Owusu-Ofori, SP Opare-Sem, O Nelson, K Cooper, R AF Layden, Jennifer E. Phillips, Richard O. Sarfo, Fred S. Owusu, Dorcas O. Mora, Nallely Forbi, Joseph Kliethermes, Stephanie Owusu-Ofori, Shirley P. Opare-Sem, Ohene Nelson, Kenrad Cooper, Richard TI Evidence for Multiple Transmission Pathways and Geographic Variation of HCV infection in Ghana, West Africa SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Layden, Jennifer E.] Loyola Univ, Med Ctr, Maywood, IL 60153 USA. [Layden, Jennifer E.; Mora, Nallely; Kliethermes, Stephanie] Loyola Univ Chicago, Maywood, IL USA. [Forbi, Joseph] CDC, Atlanta, GA 30333 USA. [Nelson, Kenrad] Johns Hopkins Univ, Baltimore, MD USA. [Phillips, Richard O.; Sarfo, Fred S.; Owusu, Dorcas O.; Owusu-Ofori, Shirley P.; Opare-Sem, Ohene; Cooper, Richard] Komfo Anokye Teaching Hosp, Kumasi, Ghana. [Phillips, Richard O.; Sarfo, Fred S.; Opare-Sem, Ohene; Cooper, Richard] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1540 BP 939A EP 939A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804103 ER PT J AU Teshale, EH Xing, J Holmberg, SD Moorman, AC Gordon, SC Rupp, LB Lu, M Spradling, P Boscarino, JA Vijayadeva, V Schmidt, MA Xu, FJ AF Teshale, Eyasu H. Xing, Jian Holmberg, Scott D. Moorman, Anne C. Gordon, Stuart C. Rupp, Loralee B. Lu, Mei Spradling, Philip Boscarino, Joseph A. Vijayadeva, Vinutha Schmidt, Mark A. Xu, Fujie TI Increased all-cause hospitalization among hepatitis C virus (HCV)-infected persons: the Chronic Hepatitis Cohort Study (CHeCS), 2006-2010 SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Teshale, Eyasu H.; Xing, Jian; Holmberg, Scott D.; Moorman, Anne C.; Spradling, Philip; Xu, Fujie] CDC, Atlanta, GA 30333 USA. [Gordon, Stuart C.; Rupp, Loralee B.; Lu, Mei] Henry Ford Hlth Syst, Detroit, MI USA. [Boscarino, Joseph A.] Geisinger Hlth Systme, Danville, PA USA. [Vijayadeva, Vinutha] Kaiser Permanente, Hawai, HI USA. [Schmidt, Mark A.] Kaiser Permanente Northwest, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1569 BP 953A EP 954A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804132 ER PT J AU Lau, D Ganova-Raeva, L Chung, RT Johnson, G Chang, KM Lisker-Melman, M Shaikh, OS Janssen, HL Wahed, AS Lok, AS AF Lau, Daryl Ganova-Raeva, Lilia Chung, Raymond T. Johnson, Geoffrey Chang, Kyong-Mi Lisker-Melman, Mauricio Shaikh, Obaid S. Janssen, Harry L. Wahed, Abdus S. Lok, Anna S. TI Prevalence of Precore and Dual Basal Core Promoter HBV Variants in a Racially Diverse Cohort of Patients with Chronic HBV Infection in North America SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Lau, Daryl] Harvard Univ, Sch Med, BIDMC, Boston, MA USA. [Ganova-Raeva, Lilia] CDC, Atlanta, GA 30333 USA. [Chung, Raymond T.] Harvard Univ, Sch Med, MGH, Boston, MA USA. [Johnson, Geoffrey; Shaikh, Obaid S.; Wahed, Abdus S.] Univ Pittsburgh, Pittsburgh, PA USA. [Chang, Kyong-Mi] Philadelphia VAMC, Philadelphia, PA USA. [Chang, Kyong-Mi] Univ Penn, Philadelphia, PA 19104 USA. [Lisker-Melman, Mauricio] Washington Univ, Sch Med, St Louis, MO USA. [Janssen, Harry L.] Toronto Western Hosp, Univ Hlth Network, Toronto, ON M5T 2S8, Canada. [Lok, Anna S.] Univ Michigan, Ann Arbor, MI 48109 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1605 BP 970A EP 971A PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804168 ER PT J AU Bruce, M Ching, L Gounder, PP Bulkow, L Spradling, PR Snowball, M Negus, S McMahon, BJ AF Bruce, Michael Ching, Lance Gounder, Prabhu P. Bulkow, Lisa Spradling, Philip R. Snowball, Mary Negus, Susan McMahon, Brian J. TI Epidemiology of Hepatitis B Virus Infection according to Genotype in Alaska Native People SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Bruce, Michael; Gounder, Prabhu P.; Bulkow, Lisa] CDC, Arctic Invest Program, Anchorage, AK USA. [Ching, Lance] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Spradling, Philip R.] CDC, Epidemiol & Surveillance Branch, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Snowball, Mary; Negus, Susan; McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1610 BP 973A EP 973A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804173 ER PT J AU Gounder, PP Bulkow, L Snowball, M Negus, S Spradling, PR Bruce, M McMahon, BJ AF Gounder, Prabhu P. Bulkow, Lisa Snowball, Mary Negus, Susan Spradling, Philip R. Bruce, Michael McMahon, Brian J. TI Hepatocellular Carcinoma Risk By Genotype Among Hepatitis B Virus Infected Alaska Native Persons Who Are Below the Age For Which Guidelines Recommend HCC Surveillance. A Population-Based Retrospective Cohort Study SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Gounder, Prabhu P.; Bulkow, Lisa; Bruce, Michael] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA. [Snowball, Mary; Negus, Susan] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA. [Spradling, Philip R.; McMahon, Brian J.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1614 BP 975A EP 975A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804177 ER PT J AU Xu, FJ Leidner, AJ Tong, X Holmberg, SD AF Xu, Fujie Leidner, Andrew J. Tong, Xin Holmberg, Scott D. TI Estimating the Number of Patients with Chronic Hepatitis C Infection According to Liver Fibrosis Stage in the United States SO HEPATOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 07-11, 2014 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Xu, Fujie; Leidner, Andrew J.; Tong, Xin; Holmberg, Scott D.] CDC, Div Viral Hepatitis, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PY 2014 VL 60 SU 1 SI SI MA 1757 BP 1044A EP 1045A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS8EW UT WOS:000344483804319 ER PT B AU Maslanka, SE AF Maslanka, Susan E. BE Foster, KA TI Botulism as a Disease of Humans SO MOLECULAR ASPECTS OF BOTULINUM NEUROTOXIN, VOL 4 SE Current Topics in Neurotoxicity LA English DT Article; Book Chapter DE Botulinum neurotoxin; Botulism; Foodborne botulism; Wound botulism; Infant botulism; Iatrogenic; Toxinfection ID A FOODBORNE BOTULISM; CLOSTRIDIUM-BOTULINUM; WOUND BOTULISM; INFANT BOTULISM; INTESTINAL COLONIZATION; LABORATORY DIAGNOSIS; IATROGENIC BOTULISM; ADVERSE EVENTS; CEREBRAL-PALSY; FERMENTED TOFU AB Human botulism presents in several different forms which provide unique challenges to public health. Foodborne botulism, while still an issue with home-processed foods, is sometimes associated with restaurants and commercially produced (particularly chilled) foods. The diversity of food products available to consumers, which are widely distributed, requires an integrated, multiagency response approach to contain, evaluate and develop appropriate prevention measures. Wound and adult intestinal toxemia cases are difficult to confirm, and so the total illness burden is likely unknown. Infant botulism highlights the diversity of the neurotoxin-producing Clostridium sp. and associated toxins which can cause botulism worldwide. Finally, an astounding number of adverse events associated with toxin injections remind us of the hazards of botulinum toxin even as its therapeutic benefits expand. C1 Ctr Dis Control & Prevent CDC, Atlanta, GA 30333 USA. RP Maslanka, SE (reprint author), Ctr Dis Control & Prevent CDC, Atlanta, GA 30333 USA. EM sht5@cdc.gov NR 127 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-9454-6; 978-1-4614-9453-9 J9 CURR TOP NEUROTOX PY 2014 VL 4 BP 259 EP 289 DI 10.1007/978-1-4614-9454-6_12 D2 10.1007/978-1-4614-9454-6 PG 31 WC Biochemistry & Molecular Biology; Neurosciences; Toxicology SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Toxicology GA BB6GC UT WOS:000344751500012 ER PT S AU Fu, PC Tolentino, H Franzke, LH AF Fu, Paul C., Jr. Tolentino, Herman Franzke, Laura H. BE Magnuson, JA Fu, PC TI Evaluation for Public Health Informatics SO PUBLIC HEALTH INFORMATICS AND INFORMATION SYSTEMS, 2ND EDITION SE Health Informatics Series LA English DT Article; Book Chapter DE Evaluation; Formative evaluation; Summative evaluation; Mental models; Evaluation frameworks; Evaluation strategies; Information value cycle; Data-information-system-context rings; Mental models; Information Value Cycle; Data-Information System-Context Rings; CDC Six-Step Evaluation Framework ID EVALUATION FRAMEWORKS; MEDICAL INFORMATICS; NETWORK ANALYSIS; SYSTEMS; CARE; IMPLEMENTATION; TECHNOLOGIES; CHALLENGES; MANAGEMENT; QUALITY AB Evaluation is the application of specific criteria to determine the value or merit of the object of the study. Ensuring that public health information systems (ISs) and programs are managed wisely is essential. Evaluation answers the question of "why" a system is necessary, by collecting the data and performing the analysis needed to make determinations of efficiency and effectiveness and is a critical component to any public health informatics (PHI) project. Evaluation should occur at all stages of a PHI project. By using a combination of formative and summative evaluation, a well-designed plan provides key data to stakeholders that allow for informed decision-making about continuing, replacing, enhancing or retiring a public health IS. The design of the evaluation plan begins with identifying a mental model (e.g., information value cycle or data-information system-context-rings) from which to view the project and the evaluation objectives and determine what to evaluate. Conceptual frameworks, evaluation strategies, and methodology toolkits help define how the evaluation plan is developed and executed. A comprehensive program (e.g., the Centers for Disease Control and Prevention's six-step evaluation framework) provides an example of an evaluation template. C1 [Fu, Paul C., Jr.] Univ Calif Los Angeles, David Geffen Sch Med, Torrance, CA 90509 USA. [Fu, Paul C., Jr.] Los Angeles Cty Harbor UCLA Med Ctr, UCLA Fielding Sch Publ Hlth, Torrance, CA 90509 USA. [Tolentino, Herman; Franzke, Laura H.] Ctr Dis Control & Prevent CDC, Sci Educ & Profess Dev Program Off, Atlanta, GA 30333 USA. RP Fu, PC (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, 1000 W Carson St,Bldg E-4, Torrance, CA 90509 USA. EM pfu@labiomed.org; cke1@cdc.gov; lfranzke@cdc.gov NR 44 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1431-1917 BN 978-1-4471-4237-9; 978-1-4471-4236-2 J9 HEALTH INFORM SER PY 2014 BP 233 EP 254 DI 10.1007/978-1-4471-4237-9_13 D2 10.1007/978-1-4471-4237-9 PG 22 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BB5NB UT WOS:000343972300015 ER PT S AU Rothwell, CJ Freedman, MA Weed, JA AF Rothwell, Charles J. Freedman, Mary Anne Weed, James A. BE Magnuson, JA Fu, PC TI The National Vital Statistics System SO PUBLIC HEALTH INFORMATICS AND INFORMATION SYSTEMS, 2ND EDITION SE Health Informatics Series LA English DT Article; Book Chapter DE Vital statistics; National Vital Statistics System; Model State Vital Statistics Act; International Classification of Disease; Vital Statistics Cooperative Program; National Center for Health Statistics; National Association for Public Health Statistics and Information Systems; US Standard Certificates; US Standard Reports; Interstate record exchange; Electronic birth registration; Electronic death registration; Mortality surveillance; State and Territorial Exchange of Vital Events; Electronic Verification of Vital Events AB The vital statistics system in the United States has always recognized the importance of collecting information about public health. Today, the national vital statistics system in the US is a major cooperative effort between the states and federal agencies. The Vital Statistics Cooperative Program provides for collection of records of births, deaths, marriages, and other events on a national level. Moreover, increasing adoption of modern technology for record keeping and data exchange has resulted in faster and more accurate vital statistics reports. State data, supplemented by surveys administered by the National Center for Health Statistics within the Centers for Disease Control and Prevention, provide fundamental information for use in the arena of public policy and public health practice. In this chapter, we will describe the history of vital statistics in the United States, and examine what data is collected and how collection methods have changed over time. In addition, we will examine the complex relationship between the collection of data at the local and state levels and the aggregation and analysis of the data by the National Center for Health Statistics. This will set the stage for a discussion of the components and uses of the present National Vital Statistics System, including an assessment of the challenges and solutions that the twenty first century presents. C1 [Rothwell, Charles J.; Weed, James A.] CDC, Natl Ctr Hlth Stat, HHS, Hyattsville, MD 20782 USA. [Freedman, Mary Anne] Poinciana Consulting LLC, Venice, FL 34293 USA. RP Rothwell, CJ (reprint author), CDC, Natl Ctr Hlth Stat, HHS, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM crothwell@cdc.gov; maryannefreedman@comcast.net; whidbey@comcast.net NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1431-1917 BN 978-1-4471-4237-9; 978-1-4471-4236-2 J9 HEALTH INFORM SER PY 2014 BP 309 EP 327 DI 10.1007/978-1-4471-4237-9_17 D2 10.1007/978-1-4471-4237-9 PG 19 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BB5NB UT WOS:000343972300019 ER PT S AU Garrett, NY AF Garrett, Nedra Y. BE Magnuson, JA Fu, PC TI Setting National Policies and Standards for Immunization Information Systems SO PUBLIC HEALTH INFORMATICS AND INFORMATION SYSTEMS, 2ND EDITION SE Health Informatics Series LA English DT Article; Book Chapter DE Immunization information systems; Standards; National; Policies; Vaccines; Decision support; Adverse events; Point of clinical care ID CHILDHOOD IMMUNIZATION AB Immunization Information Systems (IIS) are confidential, computerized, population-based systems that collect and consolidate vaccination data from vaccination providers and provide important tools for designing and sustaining effective immunization strategies (National Center for Immunization and Respiratory Diseases, Immunization information systems [Internet]. Atlanta: Centers for Disease Control and Prevention, 2013). At the point of clinical care, an IIS can provide consolidated immunization histories for use by a vaccination provider in determining appropriate client vaccinations. The Centers for Disease Control and Prevention (CDC), in collaboration with key stakeholders, works to ensure IIS are responsive to the needs of the Immunization programs at all levels of government and that these systems take advantage of advances in technology and are aligned with national data and exchange standards. CDC's Immunization program publishes IIS Minimum Functional Standards that provides a framework for the development of IIS through 2017 that describes specific standards that address the IIS programmatic goals, and operational and technical capacities that all IIS should achieve by the end of 2017. These standards were developed through a consensus process from a variety of IIS managers and technical experts from across the US. Several examples of data, standards and systems are provided for each functional standard. This chapter also will examine various policy and technology drivers such as the Centers for Medicare & Medicaid Services (CMS) EHR Incentive Programs' Meaningful Use criteria. C1 Ctr Dis Control & Prevent, Div Informat Practice Policy & Coordinat, Atlanta, GA 30333 USA. RP Garrett, NY (reprint author), Ctr Dis Control & Prevent, Div Informat Practice Policy & Coordinat, 1600 Clifton Rd,NE MS E76, Atlanta, GA 30333 USA. EM ngarrett@cdc.gov NR 27 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1431-1917 BN 978-1-4471-4237-9; 978-1-4471-4236-2 J9 HEALTH INFORM SER PY 2014 BP 355 EP 371 DI 10.1007/978-1-4471-4237-9_19 D2 10.1007/978-1-4471-4237-9 PG 17 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BB5NB UT WOS:000343972300021 ER PT S AU Tolentino, H Sangareddy, SRP Pepper, C Magnuson, JA AF Tolentino, Herman Sangareddy, Sridhar R. Papagari Pepper, Catherine Magnuson, J. A. BE Magnuson, JA Fu, PC TI Case-Based Learning in Public Health Informatics SO PUBLIC HEALTH INFORMATICS AND INFORMATION SYSTEMS, 2ND EDITION SE Health Informatics Series LA English DT Article; Book Chapter DE Problem-based learning; Case-based learning; Information Value Cycle; Case study; Complex adaptive systems; Electronic laboratory reporting; Clinical laboratory information systems ID POPULATION HEALTH AB The public health landscape is undergoing profound changes, including rapid advances in technology, increasing use of electronic health records, and health reform. Improving population health requires knowledge and skills in managing and working within the adaptive complexity of underlying societal structures and functions. These advances in technology, and profound changes within these structures and functions, introduce enormous opportunities for creating efficiencies and economies of scale, not simply for improving public health practice, but for learning as well. Finding informatics solutions to cross-cutting information needs, while solving complex health problems, requires cross-disciplinary education, research, and practice. Approaches to overcoming these challenges should address the complexity of problems within both the work and learning environments. These problem-based approachevs build skills in collaborative problem solving, critical thinking, systems thinking and lifelong learning. This chapter discusses case-based learning (CBL) as one of the methods for problem-based learning (PBL) and is aimed at the student of public health informatics (PHI) exploring this topic for the first time. The chapter concludes with a student exercise developed for fellows in the CDC Public Health Informatics Fellowship Program. C1 [Tolentino, Herman] Ctr Dis Control & Prevent CDC, Publ Hlth Informat Fellowship Program, Sci Educ & Profess Dev Program Off, Atlanta, GA 30333 USA. [Sangareddy, Sridhar R. Papagari] Ctr Dis Control & Prevent, Publ Hlth Informat Fellowship Program, Atlanta, GA 30333 USA. [Pepper, Catherine] Texas A&M Univ, Med Sci Lib, Round Rock, TX 78665 USA. [Magnuson, J. A.] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA. [Tolentino, Herman] Ctr Dis Control & Prevent CDC, Sci Educ & Profess Dev Program Off, Atlanta, GA 30333 USA. RP Tolentino, H (reprint author), Ctr Dis Control & Prevent CDC, Publ Hlth Informat Fellowship Program, Sci Educ & Profess Dev Program Off, 1600 Clifton Rd NE,Mailstop E-92, Atlanta, GA 30333 USA. EM htolentino@cdc.gov; spapagarisangareddy@cdc.gov; cpepper@tamu.edu; jamagnuson@gmail.com NR 30 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1431-1917 BN 978-1-4471-4237-9; 978-1-4471-4236-2 J9 HEALTH INFORM SER PY 2014 BP 489 EP 510 DI 10.1007/978-1-4471-4237-9_25 D2 10.1007/978-1-4471-4237-9 PG 22 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BB5NB UT WOS:000343972300027 ER PT S AU Richards, J Douglas, G Fraser, HSF AF Richards, Janise Douglas, Gerry Fraser, Hamish S. F. BE Magnuson, JA Fu, PC TI Perspectives on Global Public Health Informatics SO PUBLIC HEALTH INFORMATICS AND INFORMATION SYSTEMS, 2ND EDITION SE Health Informatics Series LA English DT Article; Book Chapter DE Global health; Global health informatics; OpenMRS; PEPFAR; HIV/AIDS; Malawi; Rwanda; EHR; Low income; Resource-constrained ID NEGLECTED TROPICAL DISEASES; MEDICAL-RECORD; HIV TREATMENT; SYSTEMS; CARE AB Public health professionals' functions are rapidly expanding beyond their countries' borders. Many academic centers are recognizing the importance of global health and are creating programs to train students to meet this growing demand. Global health centers and institutes also are being created to focus on the research and programmatic efforts needed to understand the burden of disease worldwide, as well as the financial, political, medical, policy, workforce, and infrastructure issues surrounding any solutions. Due to this emerging interest by the public health community, we need to understand where the intersection between global health and informatics occurs. For many years, the promise of what technology can do to alleviate suffering and support disease surveillance and other public health activities took precedence over understanding the environment in which the technology has to function. People and their participation in the implementation of the technological solution are critical for success. In resource-poor environments, the deployment of technological solutions faces other challenges for success. Lack of stable electrical power, availability of Internet connections, and a workforce that can support the information technology remain barriers to successful implementation. Yet, through experiences in the implementation of information technology as supported by international donors and the US President's Emergency Plan for AIDS Relief, lessons are being learned to move forward towards the benefits that global health informatics can bring. C1 [Richards, Janise] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Douglas, Gerry] Univ Pittsburgh, Dept Biomed Informat, Ctr Hlth Informat Underserved, Pittsburgh, PA 15206 USA. [Fraser, Hamish S. F.] Brigham & Womens Hosp, Div Global Hlth Equity, Dept Med, Boston, MA 02115 USA. RP Richards, J (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, 1600 Clifton Rd,M-S E30, Atlanta, GA 30333 USA. EM jrichards@cdc.gov; gdouglas@pitt.edu; hamish_fraser@hms.harvard.edu RI Fraser, Hamish/E-3773-2013 NR 38 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1431-1917 BN 978-1-4471-4237-9; 978-1-4471-4236-2 J9 HEALTH INFORM SER PY 2014 BP 619 EP 644 DI 10.1007/978-1-4471-4237-9_31 D2 10.1007/978-1-4471-4237-9 PG 26 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BB5NB UT WOS:000343972300033 ER PT J AU Tack, DM Holman, RC Folkema, AM Mehal, JM Blanton, JD Sejvar, JJ AF Tack, Danielle M. Holman, Robert C. Folkema, Arianne M. Mehal, Jason M. Blanton, Jesse D. Sejvar, James J. TI Trends in Encephalitis-Associated Deaths in the United States, 1999-2008 SO NEUROEPIDEMIOLOGY LA English DT Article DE Encephalitis; Mortality; Unspecified encephalitis ID WEST-NILE-VIRUS; NERVOUS-SYSTEM INFECTIONS; EPIDEMIOLOGY; MANAGEMENT; HIV AB Background: While encephalitis may be caused by numerous infectious, immune and toxic processes, the etiology often remains unknown. Methods: We analyzed multiple cause-of-death mortality data during 1999-2008 for the USA, using the 10th revision of International Classification of Diseases codes for encephalitis, listed anywhere on the death record, including 'specified' and 'unspecified' encephalitis. Annual and average annual age-adjusted and age-specific death rates were calculated. Results: For 1999-2008, 12,526 encephalitis-associated deaths were reported with 68.5% as unspecified encephalitis. The average annual age-adjusted encephalitis-associated death rate was 4.3 per 1 million persons, 1.3 for specified and 2.9 for unspecified encephalitis. Annual encephalitis-associated death rates had a significant downward trend (p < 0.01). The most common specified encephalitis deaths were herpesviral encephalitis (36.7%), Toxoplasma meningoencephalitis (27.8%) and Listeria meningitis/meningoencephaltis (6.8%). HIV was colisted with 15.0% of encephalitis-associated deaths, 58.4% of these with a specified code. Conclusion: Encephalitis-associated death rates decreased during 1999-2008, and herpesvirus was the most commonly identified infectious agent associated with encephalitis deaths. The high proportion of unspecified encephalitis deaths highlights the continued challenge of laboratory confirmation for causes of encephalitis and the importance of monitoring trends to assess the impact of new diagnostics and guide potential interventions. (C) 2014 S. Karger AG, Basel C1 [Tack, Danielle M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Tack, Danielle M.; Holman, Robert C.; Folkema, Arianne M.; Mehal, Jason M.; Blanton, Jesse D.; Sejvar, James J.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. RP Sejvar, JJ (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop A-30, Atlanta, GA 30333 USA. EM zea3@cdc.gov FU Centers for Disease Control and Prevention FX We would like to thank Neil Vora at CDC Poxvirus and Rabies Branch for support of this project. All work was supported by the Centers for Disease Control and Prevention. NR 28 TC 6 Z9 6 U1 0 U2 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0251-5350 EI 1423-0208 J9 NEUROEPIDEMIOLOGY JI Neuroepidemiology PY 2014 VL 43 IS 1 BP 1 EP 8 DI 10.1159/000362688 PG 8 WC Public, Environmental & Occupational Health; Clinical Neurology SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA AS0GG UT WOS:000343955500001 PM 24968857 ER PT J AU Kilinc, FS Monaghan, WD Powell, JB AF Kilinc, F. Selcen Monaghan, William D. Powell, Jeffrey B. TI A Review of Mine Rescue Ensembles for Underground Coal Mining in the United States SO JOURNAL OF ENGINEERED FIBERS AND FABRICS LA English DT Review DE mine rescue ensemble; protective clothing; personal protective equipment; fire fighter; mining ID STANDARD; STRESS; STRAIN AB The mining industry is among the top ten industries nationwide with high occupational injury and fatality rates, and mine rescue response may be considered one of the most hazardous activities in mining operations. In the aftermath of an underground mine fire, explosion or water inundation, specially equipped and trained teams have been sent underground to fight fires, rescue entrapped miners, test atmospheric conditions, investigate the causes of the disaster, or recover the dead. Special personal protective ensembles are used by the team members to improve the protection of rescuers against the hazards of mine rescue and recovery. Personal protective ensembles used by mine rescue teams consist of helmet, cap lamp, hood, gloves, protective clothing, boots, kneepads, facemask, breathing apparatus, belt, and suspenders. While improved technology such as wireless warning and communication systems, lifeline pulleys, and lighted vests have been developed for mine rescuers over the last 100 years, recent research in this area of personal protective ensembles has been minimal due to the trending of reduced exposure of rescue workers. In recent years, the exposure of mine rescue teams to hazardous situations has been changing. However, it is vital that members of the teams have the capability and proper protection to immediately respond to a wide range of hazardous situations. Currently, there are no minimum requirements, best practice documents, or nationally recognized consensus standards for protective clothing used by mine rescue teams in the United States (U. S.). The following review provides a summary of potential issues that can be addressed by rescue teams and industry to improve potential exposures to rescue team members should a disaster situation occur. However, the continued trending in the mining industry toward non-exposure to potential hazards for rescue workers should continue to be the primary goal. To assist in continuing this trend, the mining industry and regulatory agencies have been more restrictive by requiring additional post disaster information regarding atmospheric conditions and other hazards before exposing rescue workers and others in the aftermath of a mine disaster. In light of some of the more recent mine rescuer fatalities such as the Crandall Canyon Mine and Jim Walters Resources in the past years, the direction of reducing exposure is preferred. This review provides a historical perspective on ensembles used during mine rescue operations and summarizes environmental hazards, critical elements of mine rescue ensembles, and key problems with these elements. This study also identifies domains for improved mine rescue ensembles. Furthermore, field observations from several coal mine rescue teams were added to provide the information on the currently used mine rescue ensembles in the U.S. C1 [Kilinc, F. Selcen; Monaghan, William D.; Powell, Jeffrey B.] NIOSH, Ctr Dis Control & Prevent, Natl Personal Protect Technol Lab, Pittsburgh, PA 15236 USA. RP Kilinc, FS (reprint author), NIOSH, Ctr Dis Control & Prevent, Natl Personal Protect Technol Lab, 626 Cochrans Mill Rd Bldg T403, Pittsburgh, PA 15236 USA. EM fselcen@gmail.com FU Intramural CDC HHS [CC999999] NR 36 TC 0 Z9 0 U1 3 U2 8 PU INDA PI CARY PA PO BOX 1288, CARY, NC 27512-1288 USA SN 1558-9250 J9 J ENG FIBER FABR JI J. Eng. Fiber Fabr. PY 2014 VL 9 IS 1 BP 174 EP 185 PG 12 WC Materials Science, Textiles SC Materials Science GA AR7GI UT WOS:000343747100020 PM 27065231 ER PT J AU Ervin, RB Dye, BA AF Ervin, R. Bethene Dye, Bruce A. TI Associations Between Posterior Functional Contacts and Nutrient Intakes and Serum Nutrient Values Among Adults in NHANES 2003-2004 SO ORAL HEALTH & PREVENTIVE DENTISTRY LA English DT Article DE dietary recall; functional contacts; NHANES; serum nutrients ID ORAL-HEALTH COMPONENT; US ADULTS; NUTRITIONAL-STATUS; QUALITY-ASSURANCE; NATIONAL-HEALTH; NATURAL TEETH; OLDER-ADULTS; PEOPLE; DIET; FOOD AB Purpose: To examine the associations between the numbers of posterior functional contacts (FCs) and selected nutrient intakes and serum/plasma nutrient values in 3,554 adults 25 years of age and older from the 2003-2004 National Health and Nutrition Examination Survey (NHANES). Materials and Methods: FCs consist of the number of zones of contact between the maxillary and opposing mandibular posterior teeth when the maxillary and mandibular posterior teeth are together. There were 16 possible zones of contact. Nutrient intakes were calculated from one 24-h dietary recall and selected nutritional biochemistries were measured. Multivariate linear regression was used to examine the association between the numbers of FCs and nutrient intakes or serum/plasma nutrient values, controlling for potential confounding variables. Results: Males with 6 or more FCs had higher vitamin A (p < 0.05), C (p < 0.05), E (p < 0.01) and B-6 intakes (p < 0.05) than those with 5 or fewer FCs. Females with 6 or more FCs had higher dietary fiber (p < 0.05), vitamin E (p < 0.05) and folate intakes (p < 0.05) than those with 5 or fewer FCs. Males and females with 6 or more FCs had higher serum beta-carotene than those with 5 or fewer FCs (p < 0.05 and p < 0.001, respectively). Males with 6 or more FCs had higher serum folate levels than those with 5 or fewer FCs (p < 0.01), and females with 6 or more FCs had higher serum vitamin C levels than those with 5 or fewer FCs (p < 0.05). Conclusions: Dietary intakes and serum levels of certain nutrients differ by the number of FCs present. C1 [Ervin, R. Bethene] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Stat, Hyattsville, MD 20782 USA. [Dye, Bruce A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Examinat Stat, Hyattsville, MD 20782 USA. RP Dye, BA (reprint author), Natl Ctr Hlth Stat, Div Hlth Examinat Stat, 3311 Toledo Rd,Room 4416, Hyattsville, MD 20782 USA. EM bfd1@cdc.gov NR 23 TC 0 Z9 0 U1 0 U2 2 PU QUINTESSENCE PUBLISHING CO INC PI HANOVER PARK PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA SN 1602-1622 EI 1757-9996 J9 ORAL HLTH PREV DENT JI Oral Health Prev. Dent. PY 2014 VL 12 IS 3 BP 265 EP 276 DI 10.3290/j.ohpd.a31666 PG 12 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AR5LW UT WOS:000343627100010 PM 24624392 ER PT J AU Levings, JL Gunn, JP AF Levings, Jessica Lee Gunn, Janelle Peralez TI From Menu to Mouth: Opportunities for Sodium Reduction in Restaurants SO PREVENTING CHRONIC DISEASE LA English DT Article ID FOODS AB Restaurant foods can be a substantial source of sodium in the American diet. According to the Institute of Medicine, the significant contribution made by restaurants and food service menu items to Americans' sodium intake warrants targeted attention. Public health practitioners are uniquely poised to support sodium-reduction efforts in restaurants and help drive demand for lowersodium products through communication and collaboration with restaurant and food service professionals and through incentives for restaurants. This article discusses the role of the public health practitioner in restaurant sodium reduction and highlights select strategies that have been taken by state and local jurisdictions to support this effort. C1 [Levings, Jessica Lee] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Chamblee, GA 30341 USA. [Gunn, Janelle Peralez] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Levings, JL (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, MS K-72,4770 Buford Highway, Chamblee, GA 30341 USA. EM JLevings@cdc.gov NR 27 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2014 VL 11 AR 130237 DI 10.5888/pcd11.130237 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XD UT WOS:000343521600014 PM 24456646 ER PT J AU Murray, A Ellis, MU Castellanos, T Gaul, Z Sutton, MY Sneed, CD AF Murray, Ashley Ellis, Monica U. Castellanos, Ted Gaul, Zaneta Sutton, Madeline Y. Sneed, Carl D. TI Sexual health discussions between African-American mothers and mothers of Latino descent and their children SO SEX EDUCATION-SEXUALITY SOCIETY AND LEARNING LA English DT Article DE mothers; young people; sexual health conversation; African-American; Latino ID RISK BEHAVIORS; ADOLESCENT COMMUNICATION; PARENT; FAMILIES; IMPACT; PREGNANCY; PROGRAMS; YOUTH AB We examined approaches used by African-American mothers and mothers of Latino descent for informal sex-related discussions with their children to inform sexually transmitted infection (STI)/HIV intervention development efforts. We recruited mothers (of children aged 12-15) from youth service agencies and a university in southern California. Fourteen focus groups were conducted: eight with African-American mothers (n = 31) and six with mothers of Latino descent (n = 24). Data were transcribed, coded for most common themes by four of the authors and reviewed for differences by gender of child. Four key themes emerged when focusing on parent-child discussions about sex: (1) sexual activity discussions took place for both sons and daughters; (2) protection from STI/HIV and pregnancy was a key topic; (3) the use of a direct, honest approach was preferred by mothers; and (4) seizing the moment was important for discussion opportunities. These data help broaden our understanding about the strategies used by African-American mothers and mothers of Latino descent for sexual health discussions with their sons and daughters. Evaluations of these for their potential impact on youth sexual health outcomes are warranted. The data can also contribute to the development of new culturally tailored parent-child communication strategies and HIV prevention interventions for young people of colour. C1 [Murray, Ashley; Castellanos, Ted; Gaul, Zaneta; Sutton, Madeline Y.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Ellis, Monica U.] Fuller Grad Sch Psychol, Pasadena, CA USA. [Ellis, Monica U.; Sneed, Carl D.] Calif State Univ Dominguez Hills, Dept Psychol, Carson, CA USA. [Gaul, Zaneta] ICF Int, Atlanta, GA USA. RP Murray, A (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM hfx8@cdc.gov NR 39 TC 0 Z9 0 U1 1 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1468-1811 EI 1472-0825 J9 SEX EDUC-SEX SOC LEA JI Sex Educ.-Sex. Soc. Learn. PY 2014 VL 14 IS 5 SI SI BP 597 EP 608 DI 10.1080/14681811.2014.908767 PG 12 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA AR6SD UT WOS:000343712200011 ER PT J AU Hojgaard, A Lukacik, G Piesman, J AF Hojgaard, Andrias Lukacik, Gary Piesman, Joseph TI Detection of Borrelia burgdorferi, Anaplasma phagocytophilum and Babesia microti, with two different multiplex PCR assays (vol 5, pg 349, 2014) SO TICKS AND TICK-BORNE DISEASES LA English DT Correction C1 [Hojgaard, Andrias; Piesman, Joseph] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Lukacik, Gary] New York State Dept Hlth, Bur Communicable Dis Control, Albany, NY USA. RP Hojgaard, A (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM Fth3@cdc.gov NR 1 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2014 VL 5 IS 6 BP 983 EP 983 DI 10.1016/j.ttbdis.2014.07.018 PG 1 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA AR2AG UT WOS:000343385100058 ER PT S AU McKernan, JL Ellenbecker, MJ Holcroft, CA Petersen, MR AF McKernan, John L. Ellenbecker, Michael J. Holcroft, Christina A. Petersen, Martin R. GP ASHRAE TI Development and Validation of Proposed Ventilation Equations for Improved Exothermic Process Control SO ASHRAE TRANSACTIONS 2014, VOL 120, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2014 CL New York, NY SP ASHRAE ID CONVECTION; HEAT AB Exothermic or heated process contaminants have the potential to cause acute health effects such as heat stroke, and chronic effects such as manganese poisoning for an estimated 5-10 million American workers each year. Currently there are no specific occupational standards regarding exposure to heat from exothermic processes, therefore it is important to investigate techniques that can mitigate known and potential adverse occupational health effects. The research presented involved a review of the physical properties, heat transfer and meteorological theories governing buoyant air flow created by exothermic processes. These properties and theories were used to identify parameters and develop improved prediction equations required for the determination of buoyant volumetric flow used to design ventilation controls. Goals of this research were to develop and describe new (i.e. proposed) prediction equation, and compare them to currently accepted ones by Hemeon and the American Conference of Governmental Industrial Hygienists (ACGIH). Numerical assessments were conducted to compare solutions from the proposed equations for plume area, mean velocity and flow to those from the ACGIH and Hemeon. Parameters were varied for the dependent variables and solutions from the proposed, ACGIH, and Hemeon equations for plume area, mean velocity and flow were analyzed using a randomized complete block statistical design (ANOVA). Results indicate that the proposed plume mean velocity equation provides significantly greater means than either the ACGIH or Hemeon equations throughout the range of parameters investigated. The proposed equations for plume area and flow also provide significantly greater means than either the ACGIH or Hemeon equations at distances >1 m above exothermic processes. With an accurate solution for the total volumetric flow, ventilation engineers and practicing industrial hygienists are equipped with the necessary information to design and size hoods, as well as place them at an optimal distance from the source to provide adequate control of the rising plume. The equations developed will allow researchers and practitioners to determine the critical control parameters for exothermic processes, such as the exhaust flow necessary to improve efficacy and efficiency, while ensuring adequate worker protection. C1 [McKernan, John L.] EPA Off Res & Dev, Engn Tech Support Ctr, Cincinnati, OH 45268 USA. [Ellenbecker, Michael J.] U Massachusetts Lowell, Dept Work Environm, Lowell, MA USA. [Holcroft, Christina A.] Tufts Univ, Grad Sch Biomed Sci, Boston, MA 02111 USA. [Petersen, Martin R.] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH 45226 USA. RP McKernan, JL (reprint author), EPA Off Res & Dev, Engn Tech Support Ctr, Cincinnati, OH 45268 USA. NR 26 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2014 VL 120 IS 1 PG 8 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BB3GM UT WOS:000342765800069 ER PT J AU Jeffries, WL Okeke, JO Gelaude, DJ Torrone, EA Gasiorowicz, M Oster, AM McCree, DH Bertolli, J AF Jeffries, William L. Okeke, Janice O. Gelaude, Deborah J. Torrone, Elizabeth A. Gasiorowicz, Mari Oster, Alexandra M. McCree, Donna Hubbard Bertolli, Jeanne TI An exploration of religion and spirituality among young, HIV-infected gay and bisexual men in the USA SO CULTURE HEALTH & SEXUALITY LA English DT Article DE religion; spirituality; youth; gay and bisexual men; HIV; USA ID AFRICAN-AMERICAN MEN; BLACK-MEN; UNITED-STATES; PREVENTION INTERVENTION; DRUG-USE; SEX; HEALTH; RISK; HOMOPHOBIA; EXPERIENCES AB Although religion and spirituality can promote healthy behaviours and mental well-being, negative religious experiences may harm sexual minority men's health. Despite increasing vulnerability to HIV infection among young gay and bisexual men, few studies examine how religion and spirituality might affect them. To this end, we interviewed young gay and bisexual men who were diagnosed with HIV infection during January 2006-June 2009. Questionnaires assessed religious service attendance, disclosure of sexuality within religious communities, and beliefs about homosexuality being sinful. A subset described religious and spiritual experiences in qualitative interviews. We calculated the prevalence of religion- and spirituality-related factors and identified themes within qualitative interviews. Among men completing questionnaires, 66% currently attended religious services, 16% believed they could disclose their sexuality at church, and 37% believed homosexuality was sinful. Participants who completed qualitative interviews commonly discussed religious attendance and negative experiences within religious settings. They often expressed their spirituality through prayer, and some used it to cope with adverse experiences. These data suggest that religion and spirituality are notable factors that shape young, HIV-infected gay and bisexual men's social contexts. Programmes and interventions that constructively engage with religious institutions and are sensitive to spiritual beliefs may promote these men's health. Aunque la religion y la espiritualidad pueden fomentar estilos de vida saludables y el bienestar mental, las experiencias religiosas negativas pueden danar la salud de los hombres que pertenecen a minorias sexuales. Pese a la creciente vulnerabilidad a la infeccion del virus del sida entre jovenes hombres gais y bisexuales, en pocos estudios se ha examinado como podria afectarles la religion y la espiritualidad. A este fin, llevamos a cabo entrevistas a jovenes hombres gais y bisexuales a los que se diagnostico una infeccion del VIH entre enero de 2006 y junio de 2009. En los cuestionarios se abordaron cuestiones como la asistencia a oficios religiosos, la revelacion de la sexualidad en las comunidades religiosas y la creencia de que la homosexualidad es un pecado. Un subgrupo describio sus experiencias religiosas y espirituales en entrevistas cualitativas. Calculamos la prevalencia de factores relacionados con la religion y la espiritualidad e identificamos temas en estas entrevistas cualitativas. Entre los hombres que completaron los cuestionarios, el 66% asistia actualmente a oficios religiosos, el 16% creia que podria revelar su sexualidad en la iglesia, y el 37% creia que la homosexualidad era un pecado. Los participantes que completaron las entrevistas cualitativas hablaron normalmente de su asistencia a servicios religiosos y experiencias negativas en entornos religiosos. Con frecuencia expresaron su espiritualidad por medio de la oracion, y algunos lo utilizaban para sobrellevar las experiencias adversas. Estos datos indican que la religion y la espiritualidad son factores notables que forman los contextos sociales de hombres jovenes, seropositivos, gais y bisexuales. Los programas y las intervenciones que permitan participar de una manera constructiva en instituciones religiosas y tengan en cuenta las creencias espirituales podrian fomentar la salud de estos hombres. Bien que la religion et la spiritualite puissent favoriser les comportements propices a la bonne sante et au bien-etre mental, les experiences religieuses negatives peuvent nuire a la sante des hommes appartenant aux minorites sexuelles. Malgre une vulnerabilite croissante au VIH parmi les jeunes hommes gays et bisexuels, peu d'etudes ont examine comment la religion et la spiritualite peuvent les affecter. Dans cet objectif, nous avons interroge des jeunes hommes gays et bisexuels qui avaient recu un diagnostic d'infection a VIH entre janvier 2006 et juin 2009. Les questionnaires portaient sur l'assiduite aux services religieux, le devoilement de la sexualite dans les communautes religieuses et les croyances sur la nature coupable de l'homosexualite. Au cours d'entretiens qualitatifs, un sous-ensemble de participants a decrit les experiences religieuses et spirituelles. Nous avons calcule la prevalence des facteurs lies a la religion et a la spiritualite, et identifie des themes emergeant des entretiens qualitatifs. Parmi les hommes ayant rempli les questionnaires, 60 % se rendaient assidument aux services religieux ; 16 % etaient convaincus de pouvoir devoiler leur sexualite dans leur eglise; et 37 % pensaient que l'homosexualite etait coupable. Les participants aux entretiens qualitatifs ont discute, d'une maniere generale, de la pratique religieuse et des experiences negatives dans les environnements religieux. Ils exprimaient souvent leur spiritualite par la priere, et certains y avaient recours pour faire face aux experiences negatives. Ces donnees suggerent que la religion et la spiritualite sont des facteurs particuliers qui determinent les environnements sociaux des jeunes hommes gays et bisexuels infectes par le VIH. Les programmes et les interventions qui cooperent de maniere constructive avec des institutions religieuses et qui tiennent compte des croyances spirituelles pourraient favoriser la sante de ces hommes. C1 [Jeffries, William L.; Gelaude, Deborah J.; Torrone, Elizabeth A.; Oster, Alexandra M.; McCree, Donna Hubbard; Bertolli, Jeanne] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Gasiorowicz, Mari] Wisconsin Dept Hlth Serv, Div Publ Hlth, Madison, WI USA. RP Jeffries, WL (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM wjeffries@cdc.gov NR 45 TC 5 Z9 5 U1 4 U2 12 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1369-1058 EI 1464-5351 J9 CULT HEALTH SEX JI Cult. Health Sex PY 2014 VL 16 IS 9 BP 1070 EP 1083 DI 10.1080/13691058.2014.928370 PG 14 WC Family Studies; Social Sciences, Biomedical SC Family Studies; Biomedical Social Sciences GA AP6SU UT WOS:000342208800005 PM 24992268 ER PT S AU Baloch, MA AF Baloch, M. A. BE Hoorfar, J TI Leafy greens: the case study and real-life lessons from a Shiga-toxin-producing Escherichia coli (STEC) O145 outbreak in romaine lettuce SO GLOBAL SAFETY OF FRESH PRODUCE: A HANDBOOK OF BEST PRACTICE, INNOVATIVE COMMERCIAL SOLUTIONS AND CASE STUDIES SE Woodhead Publishing Series in Food Science Technology and Nutrition LA English DT Article; Book Chapter DE fresh produce-related outbreaks; E. coli O145; leafy greens; foodborne illness outbreak; environmental assessment; systems approach; outbreak investigation; environmental antecedents ID FOOD AB In April and May 2010, 33 cases of Escherichia coli O145 infections were reported from five US states. An epidemiologic investigation found that the illnesses were associated with the consumption of shredded lettuce. A traceback investigation from the processor led to a farm, Ranch A, that supplied lettuce to the processor. This chapter presents the findings of the field environmental assessment conducted in June 2010 on Ranch A and its surrounding watershed. The environmental assessment findings identify and enumerate environmental antecedents and contributing factors that might have influenced the contamination of the lettuce and the outbreak. C1 US Ctr Dis Control & Prevent, Environm Hlth Serv Branch DEEHS NCEH, Atlanta, GA 30341 USA. RP Baloch, MA (reprint author), US Ctr Dis Control & Prevent, Environm Hlth Serv Branch DEEHS NCEH, Atlanta, GA 30341 USA. EM mbaloch@cdc.gov OI Baloch, Mansoor/0000-0002-1502-086X NR 20 TC 0 Z9 0 U1 0 U2 2 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2042-8049 BN 978-1-78242-027-9; 978-1-78242-018-7 J9 WOODHEAD PUBL FOOD S JI Woodhead Publ. Food Sci. Technol. Nutr. PY 2014 IS 260 BP 340 EP 355 DI 10.1533/9781782420279.5.340 PG 16 WC Agronomy; Food Science & Technology SC Agriculture; Food Science & Technology GA BB2HQ UT WOS:000341779200026 ER PT J AU Okall, DO Ondenge, K Nyambura, M Otieno, FO Hardnett, F Turner, K Mills, LA Masinya, K Chen, RT Gust, DA AF Okall, Dancun O. Ondenge, Ken Nyambura, Monicah Otieno, Fredrick O. Hardnett, Felicia Turner, Kyle Mills, Lisa A. Masinya, Kennedy Chen, Robert T. Gust, Deborah A. TI Men Who Have Sex With Men in Kisumu, Kenya: Comfort in Accessing Health Services and Willingness to Participate in HIV Prevention Studies SO JOURNAL OF HOMOSEXUALITY LA English DT Article DE MSM; health services; participation in HIV research studies; stigma; Africa; Kenya; confidentiality ID VACCINE EFFICACY TRIAL; INFECTION; BOTSWANA; MSM AB Men who have sex with men (MSM) are a crucial and marginalized at risk population for HIV in Africa but are poorly studied. Like other areas of Africa, homosexuality is illegal in Kenya. We assessed MSM comfort in accessing health services and willingness to participate in HIV prevention research in Kisumu, Kenya-an area of high HIV prevalence. We conducted a two-phase formative study with individual interviews (n = 15) and a structured survey (n = 51). Peer contact or snowball method (n = 43, 84.3%) was the primary recruitment strategy used to locate MSM. Exact logistic regression models were used for survey data analysis. Over 60% (32/51) of survey participants were not very comfortable seeking health services from a public hospital. Almost all MSM (49/51; 96.1%) reported willingness to be contacted to participate in future HIV research studies. Efforts to provide facilities that offer safe and confidential health services and health education for MSM is required. Continued community engagement with the MSM population in Kenya is needed to guide best practices for involving them in HIV prevention research. C1 [Okall, Dancun O.; Ondenge, Ken; Nyambura, Monicah; Otieno, Fredrick O.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Hardnett, Felicia; Chen, Robert T.; Gust, Deborah A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Turner, Kyle] Inner City Fund Int, Atlanta, GA USA. [Mills, Lisa A.] Ctr Dis Control & Prevent, Kenya Med Res Inst, Kisumu, Kenya. [Masinya, Kennedy] Men AIDS Youth Grp, Kisumu, Kenya. RP Gust, DA (reprint author), CDC, Div HIV AIDS Prevent, Epidemiol Branch, Clin Trials Team, 1600 Clifton Rd,Mail Stop E-45, Atlanta, GA 30333 USA. EM dgust@cdc.gov RI Amboko, Rashidi/D-9046-2015 FU Intramural CDC HHS [CC999999] NR 24 TC 5 Z9 5 U1 0 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0091-8369 EI 1540-3602 J9 J HOMOSEXUAL JI J. Homosex. PY 2014 VL 61 IS 12 BP 1712 EP 1726 DI 10.1080/00918369.2014.951261 PG 15 WC Psychology, Multidisciplinary; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA AP8IV UT WOS:000342323600005 PM 25089554 ER PT J AU Fent, KW Durgam, S Mueller, C AF Fent, Kenneth W. Durgam, Srinivas Mueller, Charles TI Pharmaceutical Dust Exposure at Pharmacies Using Automatic Dispensing Machines: A Preliminary Study SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE pharmaceutical dust; active pharmaceutical ingredients; APIs; mail order pharmacy; outpatient pharmacy; lactose; automatic dispensing machines; robotic pill dispensers ID OCCUPATIONAL-EXPOSURE; WORKERS; METHOTREXATE; INGREDIENTS; DUSTINESS; INDUSTRY; POWDERS; LIMITS AB Automatic dispensing machines (ADMs) used in pharmacies concentrate and dispense large volumes of pharmaceuticals, including uncoated tablets that can shed dust. We evaluated 43 employees' exposures to pharmaceutical dust at three pharmacies where ADMs were used. We used an optical particle counter to identify tasks that generated pharmaceutical dust. We collected 72 inhalable dust air samples in or near the employees' breathing zones. In addition to gravimetric analysis, our contract laboratory used internal methods involving liquid chromatography to analyze these samples for active pharmaceutical ingredients (APIs) and/or lactose, an inactive filler in tablets. We had to choose samples for these additional analyses because many methods used different extraction solvents. We selected 57 samples for analysis of lactose. We used real-time particle monitoring results, observations, and information from employees on the dustiness of pharmaceuticals to select 28 samples (including 13 samples that were analyzed for lactose) for analysis of specific APIs. Pharmaceutical dust was generated during a variety of tasks like emptying and refilling of ADM canisters. Using compressed air to clean canisters and manual count machines produced the overall highest peak number concentrations (19,000-580,000 particles/L) of smallest particles (count median aerodynamic diameter <= 2 mu m). Employees who refilled, cleaned, or repaired ADM canisters, or hand filled prescriptions were exposed to higher median air concentrations of lactose (5.0-12 mu g/m(3)) than employees who did other jobs (0.04-1.3 mu g/m(3)), such as administrative/office work, labeling/packaging, and verifying prescriptions. We detected 10 APIs in air, including lisinopril, a drug prescribed for high blood pressure, levothyroxine, a drug prescribed for hypothyroidism, and methotrexate, a hazardous drug prescribed for cancer and other disorders. Three air concentrations of lisinopril (1.8-2.7 mu g/m(3)) exceeded the lower bound of the manufacturer's hazard control band (1-10 mu g/m(3)). All other API air concentrations were below applicable occupational exposure limits. Our findings indicate that some pharmacy employees are exposed to multiple APIs and that measures are needed to control those exposures. C1 [Fent, Kenneth W.; Mueller, Charles] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Durgam, Srinivas] Global Res Ctr, Niskayuna, NY USA. RP Fent, KW (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 1090 Tusculum Ave,MS R-14, Cincinnati, OH 45226 USA. EM kfent@cdc.gov NR 44 TC 0 Z9 0 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 11 BP 695 EP 705 DI 10.1080/15459624.2014.918983 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AP7UW UT WOS:000342283700005 PM 24824046 ER PT J AU Boiano, JM Steege, AL Sweeney, MH AF Boiano, James M. Steege, Andrea L. Sweeney, Marie H. TI Adherence to Safe Handling Guidelines by Health Care Workers Who Administer Antineoplastic Drugs SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE antineoplastic drug administration; safe handling practices; health care workers; hazardous drugs; chemotherapy; web-based survey ID OCCUPATIONAL EXPOSURES; AWARENESS; NURSES; CHEMOTHERAPY; PERSONNEL; SETTINGS; LEUKEMIA AB The toxicity of antineoplastic drugs is well documented. Many are known or suspected human carcinogens where no safe exposure level exists. Authoritative guidelines developed by professional practice organizations and federal agencies for the safe handling of these hazardous drugs have been available for nearly three decades. As a means of evaluating the extent of use of primary prevention practices such as engineering, administrative and work practice controls, personal protective equipment (PPE), and barriers to using PPE, the National Institute for Safety and Health (NIOSH) conducted a web survey of health care workers in 2011. The study population primarily included members of professional practice organizations representing health care occupations which routinely use or come in contact with selected chemical agents. All respondents who indicated that they administered antineoplastic drugs in the past week were eligible to complete a hazard module addressing self-reported health and safety practices on this topic. Most (98%) of the 2069 respondents of this module were nurses. Working primarily in hospitals, outpatient care centers, and physician offices, respondents reported that they had collectively administered over 90 specific antineoplastic drugs in the past week, with carboplatin, cyclophosphamide, and paclitaxel the most common. Examples of activities which increase exposure risk, expressed as percent of respondents, included: failure to wear nonabsorbent gown with closed front and tight cuffs (42%); intravenous (I. V.) tubing primed with antineoplastic drug by respondent (6%) or by pharmacy (12%); potentially contaminated clothing taken home (12%); spill or leak of antineoplastic drug during administration (12%); failure to wear chemotherapy gloves (12%); and lack of hazard awareness training (4%). The most common reason for not wearing gloves or gowns was "skin exposure was minimal"; 4% of respondents, however, reported skin contact during handling and administration. Despite the longstanding availability of safe handling guidance, recommended practices are not always followed, underscoring the importance of training and education for employers and workers. C1 [Boiano, James M.; Steege, Andrea L.; Sweeney, Marie H.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Boiano, JM (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 1090 Tusculum Ave,MSR-17, Cincinnati, OH 45226 USA. EM jboiano@cdc.gov RI Steege, Andrea/H-8900-2016 OI Steege, Andrea/0000-0001-5665-2559 FU National Institute for Occupational Safety and Health FX The authors thank Westat, Inc., for their collaboration in developing, testing, and conducting the survey. The authors are grateful to the professional practice organizations and members who participated in the survey. We also thank Seth Eisenberg, Gayle DeBord, and Tom Connor for their valuable comments on and suggestions for an early draft of the manuscript. This project was supported by the National Institute for Occupational Safety and Health. NR 33 TC 12 Z9 12 U1 3 U2 21 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 11 BP 728 EP 740 DI 10.1080/15459624.2014.916809 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AP7UW UT WOS:000342283700009 PM 24766408 ER PT J AU Breuer, D Ashley, K AF Breuer, Dietmar Ashley, Kevin TI New NIOSH Methods for Sampling and Analysis of Airborne Inorganic Acids SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID MEASURING EXPOSURE; PERFORMANCE AB Newly published NIOSH methods for inorganic acids, that are technically harmonized with relevant parallel ISO standard, have been promulgated. These methods have been extensively validated and represent significant improvements in sampling and analytical methodologies for inorganic mists and vapors in workplace atmospheres. The equivalent constructs ofmethod accuracy, as defined by theNIOSH Accuracy Criterion,((20)) and expanded uncertainty, as elucidated in EN 482((11)) and ASTM D7440((21)) (which apply the ISO/IEC Guide to the expression of uncertainty in measurement (GUM)((22)) to air quality measurements), have been previously explained by Bartley.((23)) Under these considerations is intended that, in the near future, additional occupational exposure monitoring methods based on international voluntary consensus standards will be incorporated into the NIOSH Manual of Analytical Methods. C1 [Breuer, Dietmar] IFA Inst Occupat Safety & Hlth German Social Acci, Inst Arbeitsschutz Deutsch Gesetzlichen Unfallver, D-53757 St Augustin, Germany. [Ashley, Kevin] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Breuer, D (reprint author), IFA Inst Occupat Safety & Hlth German Social Acci, Inst Arbeitsschutz Deutsch Gesetzlichen Unfallver, D-53757 St Augustin, Germany. EM dietmar.breuer@dguv.de FU IFA; NIOSH FX This work was carried out under the auspices of a formal Memorandum of Understanding (MOU) between IFA and NIOSH. NR 23 TC 0 Z9 0 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 11 BP D208 EP D211 DI 10.1080/15459624.2014.955183 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AP7UW UT WOS:000342283700004 PM 25153625 ER PT J AU Garcia, A Jones, E Echt, AS Hall, RM AF Garcia, Alberto Jones, Erica Echt, Alan S. Hall, Ronald M. TI An Evaluation of an Aftermarket Local Exhaust Ventilation Device for Suppressing Respirable Dust and Respirable Crystalline Silica Dust from Powered Saws SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article AB The objective of this study was to quantify the respirable dust and respirable silica exposures of roofing workers using an electric-powered circular saw with an aftermarket local exhaust ventilation attachment to cut concrete roofing tiles. The study was conducted to determine whether the local exhaust ventilation attachment was able to control respirable dust and respirable silica exposure below occupational exposure limits (OELs). Time-integrated filter samples and direct reading respirable dust concentrations were evaluated. The local exhaust ventilation consisted of a shroud attached to the cutting plane of the saw; the shroud was then connected to a small electric axial fan, which is intended to collect dust at the point of generation. All sampling was conducted with the control in use. Roofers are defined as those individuals who only lay tiles. Cutters/roofers are defined as those workers who operate the powered saw to cut tiles and also lay tiles. Respirable dust from this evaluation ranged from 0.13 to 6.59 milligrams per cubic meter (mg/m(3)) with a geometric mean of 0.38 mg/m(3) for roofers and from 0.45 to 3.82 mg/m(3) with a geometric mean of 1.84 mg/m(3) for cutters/roofers. Cutters/roofers usually handle areas close to crevices, edges, or tips of the roof whereas roofers handle areas where complete tiles can be placed. The respirable dust exposures for all cutters/roofers indicated concentrations exceeding the Occupational Safety and Health Administration's (OSHA) permissible exposure limit (PEL) for respirable dust containing silica; it was also exceeded for some of the roofers. The respirable silica concentrations ranged from 0.04 to 0.15 mg/m(3) with a geometric mean of 0.09 mg/m(3) for roofers, and from 0.13 to 1.21 mg/m(3) with a geometric mean of 0.48 mg/m(3) for cutters/roofers. As with respirable dust, the respirable silica exposures for cutters/roofers were higher than the exposures for roofers. C1 [Garcia, Alberto; Jones, Erica; Echt, Alan S.; Hall, Ronald M.] NIOSH, DART, Cincinnati, OH 45226 USA. RP Garcia, A (reprint author), NIOSH, 4676 Columbia Pkwy,R5, Cincinnati, OH 45226 USA. EM agarcia1@cdc.gov FU Intramural CDC HHS [CC999999] NR 11 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 11 BP D200 EP D207 DI 10.1080/15459624.2014.955182 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AP7UW UT WOS:000342283700003 PM 25148513 ER PT J AU Cunningham, TJ Ford, ES Croft, JB Merrick, MT Rolle, IV Giles, WH AF Cunningham, Timothy J. Ford, Earl S. Croft, Janet B. Merrick, Melissa T. Rolle, Italia V. Giles, Wayne H. TI Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE chronic obstructive pulmonary disease; childhood; abuse; sex ID UNITED-STATES; FEMALE SMOKERS; SMOKING; ADULTS; RISK; SURVEILLANCE; DYSFUNCTION; FRAMEWORK; ABUSE; COPD AB Purpose: Adverse childhood experiences (ACEs) before age 18 have been repeatedly associated with several chronic diseases in adulthood such as depression, heart disease, cancer, diabetes, and stroke. We examined sex-specific relationships between individual ACEs and the number of ACEs with chronic obstructive pulmonary disease (COPD) in the general population. Materials and methods: Data from 26,546 women and 19,015 men aged >= 18 years in five states of the 2011 Behavioral Risk Factor Surveillance System were analyzed. We used log-linear regression to estimate prevalence ratios (PRs) and their corresponding 95% confidence intervals (CIs) for the relationship of eight ACEs with COPD after adjustment for age group, race/ethnicity, marital status, educational attainment, employment, asthma history, health insurance coverage, and smoking status. Results: Some 63.8% of women and 62.2% of men reported >= 1 ACE. COPD was reported by 4.9% of women and 4.0% of men. In women, but not in men, there was a higher likelihood of COPD associated with verbal abuse (PR = 1.30, 95% CI: 1.05, 1.61), sexual abuse (PR = 1.69, 95% CI: 1.36, 2.10), living with a substance abusing household member (PR = 1.49, 95% CI: 1.23, 1.81), witnessing domestic violence (PR = 1.40, 95% CI: 1.14, 1.72), and parental separation/divorce (PR = 1.47, 95% CI: 1.21, 1.80) during childhood compared to those with no individual ACEs. Reporting >= 5 ACEs (PR = 2.08, 95% CI: 1.55, 2.80) compared to none was associated with a higher likelihood of COPD among women only. Conclusion: ACEs are related to COPD, especially among women. These findings underscore the need for further research that examines sex-specific differences and the possible mechanisms linking ACEs and COPD. This work adds to a growing body of research suggesting that ACEs may contribute to health problems later in life and suggesting a need for program and policy solutions. C1 [Cunningham, Timothy J.; Ford, Earl S.; Croft, Janet B.; Giles, Wayne H.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Merrick, Melissa T.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Rolle, Italia V.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Cunningham, TJ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F78, Atlanta, GA 30341 USA. EM tjcunningham@cdc.gov NR 30 TC 8 Z9 9 U1 0 U2 5 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-2005 J9 INT J CHRONIC OBSTR JI Int. J. Chronic Obstr. Pulm. Dis. PY 2014 VL 9 BP 1033 EP 1042 DI 10.2147/COPD.S68226 PG 10 WC Respiratory System SC Respiratory System GA AP6PK UT WOS:000342199500001 PM 25298732 ER PT J AU Kraft, JM Wilkins, KG Morales, GJ Widyono, M Middlestadt, SE AF Kraft, Joan Marie Wilkins, Karin Gwinn Morales, Guiliana J. Widyono, Monique Middlestadt, Susan E. TI An Evidence Review of Gender-Integrated Interventions in Reproductive and Maternal-Child Health SO JOURNAL OF HEALTH COMMUNICATION LA English DT Review ID INTIMATE PARTNER VIOLENCE; CONTRACEPTION; PROJECT; IMPACT; TRIAL; INDIA; MEN; ASSOCIATION; PREGNANCY; ETHIOPIA AB Evidence-based behavior change interventions addressing gender dynamics must be identified and disseminated to improve child health outcomes. Interventions were identified from systematic searches of the published literature and a web-based search (Google and implementer's websites). Studies were eligible if an intervention addressed gender dynamics (i.e., norms, unequal access to resources), measured relevant behavioral outcomes (e.g., family planning, antenatal care, nutrition), used at least a moderate evaluation design, and were implemented in low- or middle-income countries. Of the 23 interventions identified, 22 addressed reproductive and maternal-child health behaviors (e.g., birth spacing, antenatal care, breastfeeding) that improve child health. Eight interventions were accommodating (i.e., acknowledged, but did not seek to change gender dynamics), and 15 were transformative (i.e., sought to change gender dynamics). The majority of evaluations (n=12), including interventions that engaged men and women to modify gender norms, had mixed effects. Evidence was most compelling for empowerment approaches (i.e., participatory action for maternal-child health; increase educational and economic resources, and modify norms to reduce child marriage). Two empowerment approaches had sufficient evidence to warrant scaling-up. Research is needed to assess promising approaches, particularly those that engage men and women to modify gender norms around communication and decision making between spouses. C1 [Kraft, Joan Marie] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Wilkins, Karin Gwinn] Univ Texas Austin, Austin, TX 78712 USA. [Morales, Guiliana J.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Hlth Behav, Chapel Hill, NC USA. [Widyono, Monique] US Agcy Int Dev, Bur Global Hlth, Washington, DC 20523 USA. [Middlestadt, Susan E.] Indiana Univ Sch Publ Hlth, Bloomington, IN USA. RP Kraft, JM (reprint author), Ctr Dis Control & Prevent, DRH, 4770 Buford Highway NE,MS F74, Atlanta, GA 30341 USA. EM jik4@cdc.gov NR 57 TC 16 Z9 16 U1 4 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1081-0730 EI 1087-0415 J9 J HEALTH COMMUN JI J. Health Commun. PY 2014 VL 19 SU 1 SI SI BP 122 EP 141 DI 10.1080/10810730.2014.918216 PG 20 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA AP4QC UT WOS:000342062000007 PM 25207450 ER PT J AU Frieden, TR AF Frieden, Thomas R. TI Six Components Necessary for Effective Public Health Program Implementation SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID NEW-YORK-CITY; BLOOD-STREAM INFECTIONS; TUBERCULOSIS-CONTROL; UNITED-STATES; SMOKING; WORLDWIDE; AIR AB Public health programs succeed and survive if organizations and coalitions address 6 key areas. (1) Innovation to develop the evidence base for action; (2) a technical package of a limited number of high-priority, evidence-based interventions that together will have a major impact; (3) effective performance management, especially through rigorous, real-time monitoring, evaluation, and program improvement; (4) partnerships and coalitions with public-and private-sector organizations; (5) communication of accurate and timely information to the health care community, decision makers, and the public to effect behavior change and engage civil society; and (6) political commitment to obtain resources and support for effective action. Programs including smallpox eradication, tuberculosis control, tobacco control, polio eradication, and others have made progress by addressing these 6 areas. C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS D-14, Atlanta, GA 30333 USA. EM tfrieden@cdc.gov NR 46 TC 34 Z9 34 U1 3 U2 15 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2014 VL 104 IS 1 BP 17 EP 22 DI 10.2105/AJPH.2013.301608 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO9TW UT WOS:000341701400024 PM 24228653 ER PT J AU Laney, AS Attfield, MD AF Laney, A. Scott Attfield, Michael D. TI Examination of Potential Sources of Bias in the US Coal Workers' Health Surveillance Program SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID PROGRESSIVE MASSIVE FIBROSIS; UNITED-STATES; PNEUMOCONIOSIS; MINERS; PREVALENCE; EXPOSURE AB Objectives. We examined the potential influences of certain selection factors on the utility of the Coal Workers' Health Surveillance Program (CWHSP) data for tracking disease distribution and trends. Methods. We combined data from the CWHSP and the Energy Information Administration to examine any influence of variable worker participation on observed disease prevalence. We evaluated effects of differential participation by coal mining region, temporal changes in employment, and active surveillance efforts. Results. The published findings of pneumoconiosis distribution and trends from the CWHSP were robust compared with the various participation factors that might have affected their validity for population-based estimates of disease burden. Exploration of factors that could potentially bias the findings generally led to small increases in the primary estimates, mostly for the early years of the program. Conclusions. We confirmed previously reported findings that there was a high prevalence of coal worker pneumoconiosis (CWP) around 1970-1974, a substantial decline in 1995-1999, and indications of an increase since then. Overall our findings suggest that the previously reported distribution and trends in CWP prevalence were broadly accurate. C1 [Laney, A. Scott; Attfield, Michael D.] NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Laney, AS (reprint author), NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,Mail Stop HG900-2, Morgantown, WV 26505 USA. EM alaney@cdc.gov NR 33 TC 6 Z9 6 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2014 VL 104 IS 1 BP 165 EP 170 DI 10.2105/AJPH.2012.301051 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO9TW UT WOS:000341701400044 PM 23678894 ER PT J AU Dombkowski, KJ Cowan, AE Potter, RC Dong, SM Kolasa, M Clark, SJ AF Dombkowski, Kevin J. Cowan, Anne E. Potter, Rachel C. Dong, Shiming Kolasa, Maureen Clark, Sarah J. TI Statewide Pandemic Influenza Vaccination Reminders for Children with Chronic Conditions SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID IMMUNIZATION INFORMATION-SYSTEMS; APRIL-AUGUST 2009; UNITED-STATES; IDENTIFY CHILDREN; 2009-JANUARY 2010; ASTHMA; RECALL; NOTIFICATIONS; TECHNOLOGIES; EXPERIENCES AB Objectives. We evaluated the use of a statewide immunization information system (IIS) to target influenza vaccine reminders to high-risk children during a pandemic. Methods. We used Michigan's IIS to identify high-risk children (i.e., those with 1 chronic condition) aged 6 months to 18 years with no record of pH1N1 vaccination among children currently or previously enrolled in Medicaid (n = 202 133). Reminders were mailed on December 7, 2009. We retrospectively assessed children's eligibility for evaluation and compared influenza vaccination rates across 3 groups on the basis of their high-risk and reminder status. Results. Of the children sent reminders, 53 516 were ineligible. Of the remaining 148 617 children, vaccination rates were higher among the 142 383 high-risk children receiving reminders than among the 6234 high-risk children with undeliverable reminders and the 142 383 control group children without chronic conditions who were not sent reminders. Conclusions. Midseason reminders to parents of unvaccinated high-risk children with current or past Medicaid enrollment were associated with increased pH1N1 and seasonal influenza vaccination rates. Future initiatives should consider strategies to expand targeting of high-risk groups and improve IIS reporting during pandemic events. C1 [Dombkowski, Kevin J.; Cowan, Anne E.; Dong, Shiming; Clark, Sarah J.] Univ Michigan, Div Gen Pediat, Child Hlth Evaluat & Res Unit, Ann Arbor, MI 48109 USA. [Potter, Rachel C.] Michigan Dept Community Hlth, Lansing, MI USA. [Kolasa, Maureen] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Dombkowski, KJ (reprint author), Univ Michigan, Div Gen Pediat, 300 North Ingalls,Room 6D05, Ann Arbor, MI 48109 USA. EM kjd@med.umich.edu FU Centers for Disease Control and Prevention through Association of Prevention Teaching and Research FX This work was funded by the Centers for Disease Control and Prevention through a cooperative agreement with the Association of Prevention Teaching and Research. NR 32 TC 2 Z9 2 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2014 VL 104 IS 1 BP E39 EP E44 DI 10.2105/AJPH.2013.301662 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO9TW UT WOS:000341701400010 PM 24228668 ER PT J AU Kansagra, SM Papadouka, V Geevarughese, A Hansen, MA Konty, KJ Zucker, JR AF Kansagra, Susan M. Papadouka, Vikki Geevarughese, Anita Hansen, Michael A. Konty, Kevin J. Zucker, Jane R. TI Reaching Children Never Previously Vaccinated for Influenza Through a School-Located Vaccination Program SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID IMMUNIZATION; UNIVERSAL; CITY AB Objectives. We determined the success of the school-located vaccination (SLV) program, implemented in 2009 in New York City to deliver pandemic influenza A (H1N1) monovalent vaccine (pH1N1), versus provider offices in reaching children who had never previously received influenza vaccine. Methods. We compared the immunization history of children vaccinated in school versus provider offices. We included records in the Citywide Immunization Registry with pH1N1 administered between October 2009 and March 2010 to elementary school-aged children. Results. In total, 96 524 children received pH1N1 vaccine in schools, and 102 933 children received pH1N1 vaccine in provider offices. Of children vaccinated in schools, 34% had never received seasonal influenza vaccination in the past, compared with only 10% of children vaccinated at provider offices (P < .001). Children vaccinated in schools were more likely to have received a second dose of pH1N1 in 2009-2010 than those vaccinated in provider offices (80% vs 45%). Conclusions. The SLV program was more successful at reaching children who had never received influenza immunization in the past and should be considered as a strategy for delivering influenza vaccine in routine and emergency situations. C1 [Kansagra, Susan M.; Papadouka, Vikki; Geevarughese, Anita; Hansen, Michael A.; Konty, Kevin J.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Zucker, Jane R.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, New York, NY USA. [Zucker, Jane R.] New York City Dept Hlth & Mental Hyg, Bur Immunizat, New York, NY USA. RP Kansagra, SM (reprint author), New York City Dept Hlth & Mental Hyg, 42-09 28th St,9th Floor, Queens, NY 11101 USA. EM skansagr@health.nyc.gov FU Public Health Emergency Preparedness Cooperative Agreement [5U90TP221298-08]; Public Health Emergency Response Grant from the Centers for Disease Control and Prevention (CDC) [CDC-RFA-TP09-902-H1N109] FX All phases of this study were supported by the Public Health Emergency Preparedness Cooperative Agreement (grant no. 5U90TP221298-08) and the Public Health Emergency Response Grant (funding opportunity no. CDC-RFA-TP09-902-H1N109) from the Centers for Disease Control and Prevention (CDC). NR 20 TC 3 Z9 3 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2014 VL 104 IS 1 BP E45 EP E49 DI 10.2105/AJPH.2013.301671 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO9TW UT WOS:000341701400011 PM 24228652 ER PT J AU Kattan, JA Kudish, KS Cadwell, BL Soto, K Hadler, JL AF Kattan, Jessica A. Kudish, Kathy S. Cadwell, Betsy L. Soto, Kristen Hadler, James L. TI Effect of Vaccination Coordinators on Socioeconomic Disparities in Immunization Among the 2006 Connecticut Birth Cohort SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; RISK-FACTORS; US CHILDREN; COVERAGE; CARE; DELAY AB Objectives. We examined socioeconomic status (SES) disparities and the influence of state Immunization Action Plan-funded vaccination coordinators located in low-SES areas of Connecticut on childhood vaccination up-to-date (UTD) status at age 24 months. Methods. We examined predictors of underimmunization among the 2006 birth cohort (n = 34568) in the state's Immunization Information System, including individual demographic and SES data, census tract SES data, and residence in an area with a vaccination coordinator. We conducted multilevel logistic regression analyses. Results. Overall, 81% of children were UTD. Differences by race/ethnicity and census tract SES were typically under 5%. Not being UTD at age 7 months was the strongest predictor of underimmunization at age 24 months. Among children who were not UTD at age 7 months, only Medicaid enrollment (adjusted odds ratio [AOR] = 0.6; 95% confidence interval [CI] = 0.5, 0.7) and residence in an area with a vaccination coordinator (AOR = 0.7; 95% CI = 0.6, 0.9) significantly decreased the odds of subsequent underimmunization. Conclusions. SES disparities associated with underimmunization at age 24 months were limited. Efforts focused on vaccinating infants born in low SES circumstances can minimize disparities. C1 [Kattan, Jessica A.] Ctr Dis Control & Prevent, Hartford, CT USA. [Kattan, Jessica A.] Connecticut Dept Publ Hlth, Infect Dis Sect, Hartford, CT USA. [Kudish, Kathy S.] Connecticut Dept Publ Health, Immunizat Program, Hartford, CT USA. [Kudish, Kathy S.] Connecticut Dept Publ Health, Infect Dis Sect, Hartford, CT USA. [Cadwell, Betsy L.] CDC, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Hadler, James L.] Connecticut Emerging Infect Program, New Haven, CT USA. RP Kattan, JA (reprint author), New York City Dept Hlth & Mental Hyg, Bur Alcohol & Drug Use Prevent Care & Treatment, Gotham Ctr, 42-09 28th St,19th Floor,CN 14, Queens, NY 11101 USA. EM jkattan@health.nyc.gov NR 24 TC 3 Z9 3 U1 3 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2014 VL 104 IS 1 BP E74 EP E81 DI 10.2105/AJPH.2013.301418 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO9TW UT WOS:000341701400015 PM 24228642 ER PT J AU Shen, XX An, YL Zhang, P Wang, JP Gregg, EW Zhang, B Li, H Gong, QH Chen, YY Xing, XY Engelgau, M Hu, YH Bennett, PH Li, GW AF Shen, Xiaoxia An, Yali Zhang, Ping Wang, Jinping Gregg, Edward W. Zhang, Bo Li, Hui Gong, Qiuhong Chen, Yanyan Xing, Xiaoyan Engelgau, Michael Hu, Yinghua Bennett, Peter H. Li, Guangwei TI Both Fasting and 2-hour post load glycemic progression predicts subsequent cardiovascular events in persons with impaired glucose tolerance: 23-year follow-up of the Da Qing diabetes prevention study SO CARDIOLOGY LA English DT Meeting Abstract C1 [Shen, Xiaoxia; An, Yali; Gong, Qiuhong; Chen, Yanyan; Li, Guangwei] Fuwai Hosp, Ctr Endocrinol & Cardiovasc Dis, Beijing, Peoples R China. [Zhang, Ping; Gregg, Edward W.; Engelgau, Michael] CDC, Div Diabet Translat, Atlanta, GA 30333 USA. [Wang, Jinping; Li, Hui; Hu, Yinghua] Da Qing First Hosp, Dept Cardiol, Da Qing, Peoples R China. [Bennett, Peter H.] NIDDK, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ USA. [Zhang, Bo; Xing, Xiaoyan; Li, Guangwei] China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0008-6312 EI 1421-9751 J9 CARDIOLOGY JI Cardiology PY 2014 VL 129 SU 1 BP 11 EP 11 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AO2PY UT WOS:000341168900030 ER PT J AU Hirst, DVL Dunn, KH Shulman, SA Hammond, DR Sestito, N AF Hirst, Deborah V. L. Dunn, Kevin H. Shulman, Stanley A. Hammond, Duane R. Sestito, Nicholas TI Evaluation of Engineering Controls for the Mixing Of Flavorings Containing Diacetyl and other Volatile Ingredients SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE mixing workers; exhaust hood; diacetyl; tracer gas testing; emission control; mixing tank ID MICROWAVE-POPCORN PLANT; LUNG-DISEASE RISK; BRONCHIOLITIS OBLITERANS; MANUFACTURING-INDUSTRY; WORKERS; EXPOSURES AB Exposures to diacetyl, a primary ingredient of butter flavoring, have been shown to cause respiratory disease among workers who mix flavorings. This study focused on evaluating ventilation controls designed to reduce emissions from the flavor mixing tanks, the major source of diacetyl in the plants. Five exhaust hood configurations were evaluated in the laboratory: standard hinged lid-opened, standard hinged lid-closed, hinged lid-slotted, dome with 38-mm gap, and dome with 114-mm gap. Tracer gas tests were performed to evaluate quantitative capture efficiency for each hood. A perforated copper coil was used to simulate an area source within the 1.2-meter diameter mixing tank. Capture efficiencies were measured at four hood exhaust flow rates (2.83, 5.66, 11.3, and 17.0 cubic meters per min) and three cross draft velocities (0, 30, and 60 meters per min). All hoods evaluated performed well with capture efficiencies above 90% for most combinations of exhaust volume and cross drafts. The standard hinged lid was the least expensive to manufacture and had the best average capture efficiency (over 99%) in the closed configuration for all exhaust flow rates and cross drafts. The hinged lid-slotted hood had some of the lowest capture efficiencies at the low exhaust flow rates compared to the other hood designs. The standard hinged lid performed well, even in the open position, and it provided a flexible approach to controlling emissions from mixing tanks. The dome hood gave results comparable to the standard hinged lid but it is more expensive to manufacture. The results of the study indicate that emissions from mixing tanks used in the production of flavorings can be controlled using simple inexpensive exhaust hoods. C1 [Hirst, Deborah V. L.; Dunn, Kevin H.; Shulman, Stanley A.; Hammond, Duane R.; Sestito, Nicholas] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Hirst, DVL (reprint author), 1090 Tusculum Ave MS R-5, Cincinnati, OH 45226 USA. EM DHirst@cdc.gov FU Intramural CDC HHS [CC999999] NR 13 TC 2 Z9 2 U1 1 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 10 BP 680 EP 687 DI 10.1080/15459624.2014.904517 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO0LX UT WOS:000341001900010 PM 24649880 ER PT J AU Dunn, KH Tsai, CSJ Woskie, SR Bennett, JS Garcia, A Ellenbecker, MJ AF Dunn, Kevin H. Tsai, Candace Su-Jung Woskie, Susan R. Bennett, James S. Garcia, Alberto Ellenbecker, Michael J. TI Evaluation of Leakage From Fume Hoods Using Tracer Gas, Tracer Nanoparticles and Nanopowder Handling Test Methodologies SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID WALLED-CARBON-NANOTUBES; CENTRAL-NERVOUS-SYSTEM; TIO2 NANOPARTICLES; PERFORMANCE; MICE; TRANSLOCATION; EXPOSURES; VELOCITY; MOUSE; FLOW AB The most commonly reported control used to minimize workplace exposures to nanomaterials is the chemical fume hood. Studies have shown, however, that significant releases of nanoparticles can occur when materials are handled inside fume hoods. This study evaluated the performance of a new commercially available nano fume hood using three different test protocols. Tracer gas, tracer nanoparticle, and nanopowder handling protocols were used to evaluate the hood. A static test procedure using tracer gas (sulfur hexafluoride) and nanoparticles as well as an active test using an operator handling nanoalumina were conducted. A commercially available particle generator was used to produce sodium chloride tracer nanoparticles. Containment effectiveness was evaluated by sampling both in the breathing zone (BZ) of a mannequin and operator as well as across the hood opening. These containment tests were conducted across a range of hood face velocities (60, 80, and 100 ft/min) and with the room ventilation system turned off and on. For the tracer gas and tracer nanoparticle tests, leakage was much more prominent on the left side of the hood (closest to the room supply air diffuser) although some leakage was noted on the right side and in the BZ sample locations. During the tracer gas and tracer nanoparticle tests, leakage was primarily noted when the room air conditioner was on for both the low and medium hood exhaust airflows. When the room air conditioner was turned off, the static tracer gas tests showed good containment across most test conditions. The tracer gas and nanoparticle test results were well correlated showing hood leakage under the same conditions and at the same sample locations. The impact of a room air conditioner was demonstrated with containment being adversely impacted during the use of room air ventilation. The tracer nanoparticle approach is a simple method requiring minimal setup and instrumentation. However, the method requires the reduction in background concentrations to allow for increased sensitivity. C1 [Dunn, Kevin H.; Bennett, James S.; Garcia, Alberto; Ellenbecker, Michael J.] NIOSH, Div Appl Res & Technol, Engn & Phys Hazards Branch, Cincinnati, OH 45226 USA. [Tsai, Candace Su-Jung] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA. [Woskie, Susan R.] Univ Massachusetts, Coll Hlth Sci, Dept Work Environm, Lowell, MA USA. RP Dunn, KH (reprint author), NIOSH, MS R5,1090 Tusculum Ave, Cincinnati, OH 45226 USA. EM KDunn@cdc.gov FU Intramural CDC HHS [CC999999] NR 22 TC 1 Z9 1 U1 3 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 10 BP D164 EP D173 DI 10.1080/15459624.2014.933959 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO0LX UT WOS:000341001900003 PM 25175285 ER PT J AU Esswein, EJ Snawder, J King, B Breitenstein, M Alexander-Scott, M Kiefer, M AF Esswein, Eric J. Snawder, John King, Bradley Breitenstein, Michael Alexander-Scott, Marissa Kiefer, Max TI Evaluation of Some Potential Chemical Exposure Risks During Flowback Operations in Unconventional Oil and Gas Extraction: Preliminary Results SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID WORKERS C1 [Esswein, Eric J.; King, Bradley; Kiefer, Max] NIOSH, Western States Off, Denver, CO 80225 USA. [Snawder, John; Breitenstein, Michael; Alexander-Scott, Marissa] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Esswein, EJ (reprint author), NIOSH, Western States Off, Denver, CO 80225 USA. EM eje1@cdc.gov NR 19 TC 5 Z9 5 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 10 BP D174 EP D184 DI 10.1080/15459624.2014.933960 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO0LX UT WOS:000341001900004 PM 25175286 ER PT J AU Rahman, AM Murrow, JR Ozkor, MA Kavtaradze, N Lin, J De Staercke, C Hooper, WC Manatunga, A Hayek, S Quyyumi, AA AF Rahman, Ayaz M. Murrow, Jonathan R. Ozkor, Muhiddin A. Kavtaradze, Nino Lin, Ji De Staercke, Christine Hooper, W. Craig Manatunga, Amita Hayek, Salim Quyyumi, Arshed A. TI Endothelium-Derived Hyperpolarizing Factor Mediates Bradykinin-Stimulated Tissue Plasminogen Activator Release in Humans SO JOURNAL OF VASCULAR RESEARCH LA English DT Article DE Bradykinin; Endothelium; Endothelium-derived hyperpolarizing factors; Fibrinolysis; Tissue plasminogen activator ID CORONARY-ARTERIES; HUMAN FOREARM; EPOXYEICOSATRIENOIC ACIDS; DEPENDENT HYPERPOLARIZATION; CYTOCHROME P4502C9; TETRAETHYLAMMONIUM IONS; MYOCARDIAL-INFARCTION; POTASSIUM CHANNELS; CIGARETTE-SMOKING; HYDROGEN-PEROXIDE AB Aims: Bradykinin (BK) stimulates tissue plasminogen activator (t-PA) release from human endothelium. Although BK stimulates both nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) release, the role of EDHF in t-PA release remains unexplored. This study sought to determine the mechanisms of BK-stimulated t-PA release in the forearm vasculature of healthy human subjects. Methods: In 33 healthy subjects (age 40.3 +/- 1.9 years), forearm blood flow (FBF) and t-PA release were measured at rest and after intra-arterial infusions of BK (400 ng/min) and sodium nitroprusside (3.2 mg/min). Measurements were repeated after intra-arterial infusion of tetraethylammonium chloride (TEA; 1 mu mol/min), fluconazole (0.4 mu mol.min(-1).l(-1)), and N-G-monomethyl-L-arginine (L-NMMA, 8 mu mol/min) to block nitric oxide, and their combination in separate studies. Results: BK significantly increased net t-PA release across the forearm (p < 0.0001). Fluconazole attenuated both BK-mediated vasodilation (-23.3 +/- 2.7% FBF, p < 0.0001) and t-PA release (from 50.9 +/- 9.0 to 21.3 +/- 8.9 ng/min/100 ml, p = 0.02). TEA attenuated FBF (-14.7 +/- 3.2%, p = 0.002) and abolished BK-stimulated t-PA release (from 22.9 +/- 5.7 to -0.8 +/- 3.6 ng/min/100 ml, p = 0.0002). L-NMMA attenuated FBF (p < 0.0001), but did not inhibit BK-induced t-PA release (nonsignificant). Conclusion: BK-stimulated t-PA release is partly due to cytochrome P-450-derived epoxides and is inhibited by K-Ca(+) channel blockade. Thus, BK stimulates both EDHF-dependent vasodilation and t-PA release. (C) 2014 S. Karger AG, Basel C1 [Rahman, Ayaz M.; Murrow, Jonathan R.; Ozkor, Muhiddin A.; Kavtaradze, Nino; Hayek, Salim; Quyyumi, Arshed A.] Emory Univ, Sch Med, Div Cardiol, Dept Med, Atlanta, GA 30322 USA. [Lin, Ji; Manatunga, Amita] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [De Staercke, Christine; Hooper, W. Craig] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Quyyumi, AA (reprint author), Emory Univ, Sch Med, 1462 Clifton Rd NE,Suite F506, Atlanta, GA 30322 USA. EM aquyyum@emory.edu OI Hayek, Salim/0000-0003-0180-349X FU National Institutes of Health Research [RO1 HL79115]; Clinical and Translational Science Award Program [UL1 RR025008]; General Clinical Research Center program [M01 RR00039]; National Institutes of Health; National Center for Research Resources; British Cardiovascular Society Research Fellowship; National Blood Foundation; NIH NRSA Training Grant [T32]; American College of Cardiology Foundation Keating Fellowship FX The study was supported by National Institutes of Health Research Grant RO1 HL79115, and in part by PHS Grant UL1 RR025008 from the Clinical and Translational Science Award Program, and PHS Grant M01 RR00039 from the General Clinical Research Center program, National Institutes of Health, National Center for Research Resources, the British Cardiovascular Society Research Fellowship, National Blood Foundation, NIH NRSA T32 Training Grant, American College of Cardiology Foundation Keating Fellowship, and the American Heart Association Beginning Grant-in-Aid. NR 57 TC 3 Z9 3 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1018-1172 EI 1423-0135 J9 J VASC RES JI J. Vasc. Res. PY 2014 VL 51 IS 3 BP 200 EP 208 DI 10.1159/000362666 PG 9 WC Physiology; Peripheral Vascular Disease SC Physiology; Cardiovascular System & Cardiology GA AO2PZ UT WOS:000341169000004 PM 24925526 ER PT S AU Sejvar, J AF Sejvar, James BE Tselis, AC Booss, J TI Neuroepidemiology and the epidemiology of viral infections of the nervous system SO NEUROVIROLOGY SE Handbook of Clinical Neurology LA English DT Article; Book Chapter ID WEST-NILE-VIRUS; CREUTZFELDT-JAKOB-DISEASE; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SUBACUTE SCLEROSING-PANENCEPHALITIS; HERPES-SIMPLEX ENCEPHALITIS; HUMAN PRION DISEASES; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; IMMUNIZATION SAFETY DATA; ACUTE FLACCID PARALYSIS; GUILLAIN-BARRE-SYNDROME C1 [Sejvar, James] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. RP Sejvar, J (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA. EM zea3@cdc.gov FU Intramural CDC HHS [CC999999] NR 113 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0072-9752 BN 978-0-444-53488-0; 978-0-702-04539-4 J9 HAND CLINIC PY 2014 VL 123 BP 67 EP 87 PG 21 WC Clinical Neurology SC Neurosciences & Neurology GA BB1EM UT WOS:000341048300005 PM 25015481 ER PT S AU Sejvar, J AF Sejvar, James BE Tselis, AC Booss, J TI Vaccines and viral/toxin-associated neurologic infections SO NEUROVIROLOGY SE Handbook of Clinical Neurology LA English DT Article; Book Chapter ID GUILLAIN-BARRE-SYNDROME; ACUTE NECROTIZING ENCEPHALOPATHY; IMMUNIZATION PRACTICES ACIP; SUBACUTE SCLEROSING-PANENCEPHALITIS; ACUTE DISSEMINATED ENCEPHALOMYELITIS; INFLUENZA-ASSOCIATED ENCEPHALOPATHY; TICK-BORNE ENCEPHALITIS; CENTRAL-NERVOUS-SYSTEM; PREVENT HERPES-ZOSTER; PRACTICE RESEARCH DATABASE C1 [Sejvar, James] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. RP Sejvar, J (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA. EM zea3@cdc.gov NR 258 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0072-9752 BN 978-0-444-53488-0; 978-0-702-04539-4 J9 HAND CLINIC PY 2014 VL 123 BP 719 EP 744 PG 26 WC Clinical Neurology SC Neurosciences & Neurology GA BB1EM UT WOS:000341048300038 PM 25015514 ER PT J AU Zilversmit, L Sappenfield, O Zotti, M McGehee, MA AF Zilversmit, Leah Sappenfield, Olivia Zotti, Marianne McGehee, Mary A. TI Preparedness Planning for Emergencies Among Postpartum Women in Arkansas During 2009 SO WOMENS HEALTH ISSUES LA English DT Article ID HOUSEHOLD PREPAREDNESS; DISASTER PREPAREDNESS; HURRICANE-KATRINA; HEALTH; POSTDISASTER; COMMUNICATION AB Purpose: Having an emergency plan may reduce negative effects of disaster on the health of postpartum women and their infants. However, little is known about the prevalence of emergency plans among postpartum women. In 2009, Arkansas added a question to the Pregnancy Risk Assessment Monitoring System surveillance system about whether women who gave birth that year had an emergency plan. In this study, we first describe the sociodemographic characteristics, disaster experience, and region of residence of postpartum women in Arkansas who indicated that they had an emergency plan for their families in 2009, and second, examine associations between sociodemographic characteristics and disaster experience and the presence of an emergency plan. Methods: Multivariable logistic regression (n = 1,173) was conducted to examine associations between maternal race/ethnicity, sociodemographic characteristics, region of residence, disaster experience, and having a disaster plan. We adjusted for maternal education, federal poverty level, and family size in our final model. Findings: Forty-eight percent (n = 559) of women reported having an emergency plan. Hispanic women were less likely to report having a plan compared with non-Hispanic White women (n = 102 [10%]; adjusted prevalence ratio [aPR], 0.6; 95% confidence interval [CI], 0.4-0.9). Families with five or more members were more likely to have a plan compared with smaller families (n = 123 [11%]; aPR, 1.3; 95% CI, 1.1-1.6). Conclusions: Policymakers and public health practitioners can use these results to promote emergency planning among postpartum women in Arkansas, with special outreach to postpartum women who are Hispanic or have smaller families. Copyright (C) 2014 by the Jacobs Institute of Women's Health. Published by Elsevier Inc. C1 [Zilversmit, Leah; Sappenfield, Olivia; Zotti, Marianne] Ctr Dis Control & Prevent, Div Reprod Hlth, Appl Sci Branch, Atlanta, GA USA. [McGehee, Mary A.] Ctr Publ Hlth Practice, Arkansas Dept Hlth, Hlth Stat Branch, Little Rock, AR USA. RP Zilversmit, L (reprint author), 617 Viale Machiavelli Lane, Henderson, NV 89011 USA. EM lzilver@gmail.com NR 29 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 EI 1878-4321 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD JAN-FEB PY 2014 VL 24 IS 1 BP E83 EP E88 DI 10.1016/j.whi.2013.10.006 PG 6 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA AO1YW UT WOS:000341112500013 PM 24439951 ER PT J AU Thienkrua, W Todd, CS Chaikummao, S Sukwicha, W Yafant, S Tippanont, N Varangrat, A Khlaimanee, P Holtz, TH AF Thienkrua, Warunee Todd, Catherine S. Chaikummao, Supaporn Sukwicha, Wichuda Yafant, Somsak Tippanont, Narongritt Varangrat, Anchalee Khlaimanee, Pechpailin Holtz, Timothy H. TI Prevalence and correlates of willingness to participate in a rectal microbicide trial among men who have sex with men in Bangkok SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE rectal microbicide; men who have sex with men; clinical trial; HIV; prevention ID PERU IMPLICATIONS; ANAL INTERCOURSE; LUBRICANT USE; GAY-MEN; HIV; THAILAND; ACCEPTABILITY; GEL; INFECTION; SAFETY AB Rectal microbicides (RMs) hold promise as a HIV prevention method to reduce transmission among men who have sex with men (MSM). To assess RM trial feasibility in Bangkok, we measured prevalence and correlates of willingness to participate among Thai MSM observational cohort participants. Between April 2006 and December 2010, 1744 MSM enrolled in the Bangkok MSM Cohort Study; at 12 months, RM trial participation willingness was measured. We evaluated correlates of RM trial participation willingness using logistic regression analysis. Participants completing the 12-month visit (81.4%, n = 1419) had a mean age of 27.3 years (SD = 6.1), and 65.5% and 86.1% reported having a steady partner or anal intercourse (AI) in the past four months, respectively. Most (79.1%, n = 1123) participants reported willingness to participate in an RM trial, which, in multivariable analysis, was independently associated with insertive only (adjusted odds ratio [AOR] = 3.25, 95% CI: 1.82-5.81) or receptive/versatile role AI (AOR = 3.07, 95% CI: 1.88-5.01), and being paid for sex (AOR = 12.15, 95% CI: 1.67-88.21) in the past four months, and believing that people with AIDS look sick (AOR = 1.92, 95% CI: 1.23-2.98). Of hypothetical RM trial features to increase enrollment likelihood, the most (91.1%) compelling was that the study be approved by the Thai ethics committee, followed by the study site offering evening hours (88.9%). Reasons not to participate were not wanting a rectal examination (29.5%) or fluid collected from the penis or anus (24.6%) and not wanting the placebo (23.0%). RM trial participation willingness was high, particularly for those with greater HIV acquisition risk, within this Thai MSM cohort, suggesting feasibility of an RM trial. Addressing potential barriers to trial entry may be useful in educational materials to optimize recruitment. C1 [Thienkrua, Warunee; Chaikummao, Supaporn; Sukwicha, Wichuda; Yafant, Somsak; Tippanont, Narongritt; Varangrat, Anchalee; Khlaimanee, Pechpailin; Holtz, Timothy H.] Thailand MOPH US CDC Collaborat TUC, HIV STD Res Program, Nonthaburi, Thailand. [Todd, Catherine S.] FHI 360, Asia Pacific Reg Off, Bangkok, Thailand. [Holtz, Timothy H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Thienkrua, W (reprint author), Thailand MOPH US CDC Collaborat TUC, HIV STD Res Program, Nonthaburi, Thailand. EM waruneet@cdc.gov NR 34 TC 2 Z9 2 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2014 VL 26 IS 11 BP 1359 EP 1369 DI 10.1080/09540121.2014.913763 PG 11 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AN2ZB UT WOS:000340453500006 PM 24797186 ER PT J AU Yard, EE Murphy, MW Schneeberger, C Narayanan, J Hoo, E Freiman, A Lewis, LS Hill, VR AF Yard, Ellen E. Murphy, Matthew W. Schneeberger, Chandra Narayanan, Jothikumar Hoo, Elizabeth Freiman, Alexander Lewis, Lauren S. Hill, Vincent R. TI Microbial and chemical contamination during and after flooding in the Ohio River-Kentucky, 2011 SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING LA English DT Article DE Natural disaster; emergency response; floods ID REAL-TIME PCR; TAP WATER SAMPLES; HURRICANE-KATRINA; SURFACE-WATER; UNITED-STATES; NEW-ORLEANS; ULTRAFILTRATION; RECOVERY; FLOODWATER; PATHOGENS AB Surface water contaminants in Kentucky during and after 2011 flooding were characterized. Surface water samples were collected during flood stage (May 2-4, 2011; n = 15) and after (July 25-26, 2011; n = 8) from four different cities along the Ohio River and were analyzed for the presence of microbial indicators, pathogens, metals, and chemical contaminants. Contaminant concentrations during and after flooding were compared using linear and logistic regression. Surface water samples collected during flooding had higher levels of E. coli, enterococci, Salmonella, Campylobacter, E. coli O157:H7, adenovirus, arsenic, copper, iron, lead, and zinc compared to surface water samples collected 3-months post-flood (P < 0.05). These results suggest that flooding increases microbial and chemical loads in surface water. These findings reinforce commonly recommended guidelines to limit exposure to flood water and to appropriately sanitize contaminated surfaces and drinking wells after contamination by flood water. C1 [Yard, Ellen E.; Murphy, Matthew W.; Lewis, Lauren S.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Yard, Ellen E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Schneeberger, Chandra; Narayanan, Jothikumar; Hill, Vincent R.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Schneeberger, Chandra] IHRC Inc, Atlanta, GA USA. [Hoo, Elizabeth; Freiman, Alexander] Kentucky Dept Publ Hlth, Div Publ Hlth Protect & Safety, Frankfort, KY USA. [Hoo, Elizabeth; Freiman, Alexander] Kentucky Dept Publ Hlth, Div Epidemiol & Hlth Planing, Frankfort, KY USA. [Hoo, Elizabeth] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA. RP Yard, EE (reprint author), CDC NCEH HSB, 4770 Buford Hwy NE,MS F-60, Chamblee, GA 30341 USA. EM eyard@cdc.gov NR 35 TC 1 Z9 1 U1 4 U2 21 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-4529 EI 1532-4117 J9 J ENVIRON SCI HEAL A JI J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng. PY 2014 VL 49 IS 11 BP 1236 EP 1243 DI 10.1080/10934529.2014.910036 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AN1UM UT WOS:000340369200005 PM 24967556 ER PT J AU Dubey, P Ghia, U Turkevich, LA AF Dubey, Prahit Ghia, Urmila Turkevich, Leonid A. TI Numerical Investigation of Sheath and Aerosol Flows in the Flow Combination Section of a Baron Fiber Classifier SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID ALVEOLAR MACROPHAGES; GLASS-FIBERS; LENGTH; CYTOTOXICITY; ASBESTOS; DIELECTROPHORESIS; CHRYSOTILE; DIMENSIONS; SEPARATION; WORKERS AB The Baron fiber classifier is an instrument used to separate fibers by length. The flow combination section (FCS) of this instrument is an upstream annular region, where an aerosol of uncharged fibers is introduced along with two sheath flows; length separation occurs by dielectrophoresis downstream in the flow classification section. In its current implementation at NIOSH, the instrument is capable of processing only very small quantities of fibers. In order to prepare large quantities of length-separated fibers for toxicological studies, the throughput of the instrument needs to be increased, and hence, higher aerosol flow rates need to be considered. However, higher aerosol flow rates may give rise to flow separation or vortex formation in the FCS, arising from the sudden expansion of the aerosol at the inlet nozzle. The goal of the present investigation is to understand the interaction of the sheath and aerosol flows inside the FCS, using computational fluid dynamics (CFD), and to identify possible limits to increasing aerosol flow rates. Numerical solutions are obtained using an axisymmetric model of the FCS, and solving the Navier-Stokes equations governing these flows; in this study, the aerosol flow is treated purely aerodynamically. Results of computations are presented for four different flow rates. The geometry of the converging outer cylinder, along with the two sheath flows, is effective in preventing vortex formation in the FCS for aerosol-to-sheath flow inlet velocity ratios below similar to 50. For higher aerosol flow rates, recirculation is observed in both inner and outer sheaths. Results for velocity, streamlines, and shear stress are presented. C1 [Dubey, Prahit; Ghia, Urmila] Univ Cincinnati, Dept Mech & Mat Engn, Coll Engn & Appl Sci, Cincinnati, OH USA. [Turkevich, Leonid A.] Ctr Dis Control & Prevent, Chem Exposure & Monitoring Branch, Div Appl Res & Technol, NIOSH, Cincinnati, OH 45226 USA. RP Turkevich, LA (reprint author), Ctr Dis Control & Prevent, Chem Exposure & Monitoring Branch, Div Appl Res & Technol, NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM LLT0@cdc.gov FU NIOSH NORA program FX This work was supported, in part, under the NIOSH NORA program. NR 36 TC 0 Z9 0 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2014 VL 48 IS 8 BP 896 EP 905 DI 10.1080/02786826.2014.936342 PG 10 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AM8RZ UT WOS:000340146100011 PM 26388662 ER PT J AU Medley, A Seth, P Pathak, S Howard, AA DeLuca, N Matiko, E Mwinyi, A Katuta, F Sheriff, M Makyao, N Wanjiku, L Ngare, C Bachanas, P AF Medley, Amy Seth, Puja Pathak, Sonal Howard, Andrea A. DeLuca, Nickolas Matiko, Eva Mwinyi, Abubakari Katuta, Frieda Sheriff, Mushin Makyao, Neema Wanjiku, Lucy Ngare, Carol Bachanas, Pamela TI Alcohol use and its association with HIV risk behaviors among a cohort of patients attending HIV clinical care in Tanzania, Kenya, and Namibia SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE alcohol use; HIV/AIDS; HIV risk behavior; sub-Saharan Africa ID SUB-SAHARAN AFRICA; ANTIRETROVIRAL THERAPY; SOUTH-AFRICA; DISEASE PROGRESSION; CAPE-TOWN; MEDICATION ADHERENCE; SEXUAL-BEHAVIORS; CONSUMPTION; INFECTION; UGANDA AB This article describes the frequency of alcohol use among HIV-positive patients attending clinical care in sub-Saharan Africa and explores the association between alcohol use, medication adherence, and sexual risk behavior. Data from 3538 patients attending an HIV clinic in Kenya, Tanzania, or Namibia were captured through interview and medical record abstraction. Participants were categorized into three drinking categories: nondrinkers, nonharmful drinkers, and harmful/likely dependent drinkers. A proportional odds model was used to identify correlates associated with categories of alcohol use. Overall, 20% of participants reported alcohol use in the past 6 months; 15% were categorized as nonharmful drinkers and 5% as harmful/likely dependent drinkers. Participants who reported missing a dose of their HIV medications [adjusted odds ratio (AOR): 2.04, 95% confidence interval (CI): 1.67, 2.49]; inconsistent condom use (AOR: 1.49, 95% CI: 1.23, 1.79); exchanging sex for food, money, gifts, or a place to stay (AOR: 1.57, 95% CI: 1.06, 2.32); and having a sexually transmitted infection symptom (AOR: 1.40, 95% CI: 1.10, 1.77) were more likely to be categorized in the higher risk drinking categories. This research highlights the need to integrate alcohol screening and counseling into the adherence and risk reduction counseling offered to HIV-positive patients as part of their routine care. Moreover, given the numerous intersections between alcohol and HIV, policies that focus on reducing alcohol consumption and alcohol-related risk behavior should be integrated into HIV prevention, care, and treatment strategies. C1 [Medley, Amy; Seth, Puja; DeLuca, Nickolas; Bachanas, Pamela] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Pathak, Sonal] ICF Int, Atlanta, GA USA. [Howard, Andrea A.] Columbia Univ, Int Ctr AIDS Care & Treatment Programs ICAP, New York, NY USA. [Matiko, Eva] US Ctr Dis Control & Prevent, Dar Es Salaam, Tanzania. [Mwinyi, Abubakari] Columbia Univ, Int Ctr AIDS Care & Treatment Programs ICAP, Dar Es Salaam, Tanzania. [Katuta, Frieda] Minist Hlth & Social Serv, Windhoek, Namibia. [Sheriff, Mushin] Columbia Univ, Int Ctr AIDS Care & Treatment Programs ICAP, Nairobi, Kenya. [Makyao, Neema] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. [Wanjiku, Lucy] US Ctr Dis Control & Prevent, Nairobi, Kenya. [Ngare, Carol] Natl AIDS STD Control Programme NASCOP, Nairobi, Kenya. RP Medley, A (reprint author), US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM amedley@cdc.gov FU Intramural CDC HHS [CC999999] NR 55 TC 6 Z9 7 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2014 VL 26 IS 10 BP 1288 EP 1297 DI 10.1080/09540121.2014.911809 PG 10 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AM8NJ UT WOS:000340132300013 PM 24773163 ER PT J AU Djawe, K Brown, EEJ Gaul, Z Sutton, M AF Djawe, Kpandja Brown, Emma E. J. Gaul, Zaneta Sutton, Madeline TI Community-based electronic data collections for HIV prevention research with black/African-American men in the rural, Southern USA SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE ACASI; feasibility; low-income; rural; HIV; black men ID ASSISTED SELF-INTERVIEW; SEXUAL-BEHAVIOR; AUDIO; ACASI; ACCEPTABILITY; POPULATION; ATTITUDES; MODES; YOUTH AB In Florida, the HIV case rate among black men is five times that of white men; tailored HIV prevention interventions are lacking. Historical concerns regarding trust with public health venues and sharing sensitive information make face-to-face data collection with some rural, southern black men challenging. We evaluated the feasibility and acceptability of using audio computer-assisted self-interviews (ACASIs) by local community-based organization members to collect HIV-related information from black men in rural settings. We used logistic regression to estimate associations between using ACASI and participants' sociodemographic characteristics. Of 636 men approached, 586 (92.0%) participated, 479 (81.7%) never completed a computer survey, and 287 (71%) of those reporting a preference preferred ACASI for future data collections. Increased age, past computer use, and sharing a household with someone were significantly associated with ACASI feasibility and acceptability. Using ACASI with black men in rural settings is feasible for HIV intervention research and disparity-reducing goals. C1 [Djawe, Kpandja; Gaul, Zaneta; Sutton, Madeline] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Brown, Emma E. J.] Res & Program Evaluat CHARM Inc, Lake City, FL USA. [Gaul, Zaneta] ICF Int, Atlanta, GA USA. RP Djawe, K (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM wgp6@cdc.gov NR 46 TC 3 Z9 3 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2014 VL 26 IS 10 BP 1309 EP 1317 DI 10.1080/09540121.2014.911812 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AM8NJ UT WOS:000340132300016 PM 24773187 ER PT J AU Esona, MD Mijatovic-Rustempasic, S Yen, C Parashar, UD Gentsch, JR Bowen, MD LaRussa, P AF Esona, Mathew D. Mijatovic-Rustempasic, Slavica Yen, Catherine Parashar, Umesh D. Gentsch, Jon R. Bowen, Michael D. LaRussa, Philip TI Detection of PCV-2 DNA in stool samples from infants vaccinated with RotaTeq (R) SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE rotavirus vaccines; porcine circovirus; shedding; stool; DNA ID HUMAN ROTAVIRUS VACCINE; CIRCOVIRUS TYPE-1 PCV1; PORCINE-CIRCOVIRUS; CONTAMINATION; CHILDREN AB Rotarix (R) and RotaTeq (R) vaccines have led to a dramatic reduction in rotavirus disease worldwide. However, the detection of porcine circovirus type 1 (PCV-1) and 2 (PCV-2) DNA in these vaccines raised some safety concerns. Studies examining shedding of rotavirus in stool from rotavirus vaccine recipients have been performed but no published data exist regarding the shedding of PCV virus in stools of vaccinees. The goal of this study was to determine if PCV-1 and/or PCV-2 is shed in the feces of infants vaccinated with RotaTeq (R). Using multiple PCR assays for detection of PCV DNA, we tested for PCV-1 and PCV-2 in 826 stool swab samples collected serially during the first 9 d after vaccination from 102 children vaccinated with RotaTeq (R). Since the vaccine is recommended and uptake is high, we did not have samples from unvaccinated infants. A total of 235 (28.5%) samples from 59 vaccine recipients were positive for PCV-2 DNA by one or more assays used in this study. PCV-1 DNA was not detected in RotaTeq (R) or any of the stool swab extracts. Twenty-two of the 102 vaccine recipients (21.6%) shed RotaTeq (R) vaccine strain and 10 of these vaccinees (9.8%) were shedding both PCV DNA and rotavirus vaccine RNA. PCV DNA was detected up to 9 d post vaccination and was most frequently detected in the first 5 d after vaccination. This study demonstrated shedding of PCV-2 DNA by RotaTeq (R) vaccinees but we did not find evidence that this DNA was associated with viable PCV. Findings from this study support the continued use of current rotavirus vaccines. C1 [Esona, Mathew D.; Mijatovic-Rustempasic, Slavica; Yen, Catherine; Parashar, Umesh D.; Gentsch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Yen, Catherine; LaRussa, Philip] Columbia Univ, Coll Phys & Surg, New York, NY 10027 USA. RP LaRussa, P (reprint author), Columbia Univ, Coll Phys & Surg, New York, NY 10027 USA. EM plarussa@columbia.edu NR 25 TC 6 Z9 6 U1 0 U2 3 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JAN PY 2014 VL 10 IS 1 BP 25 EP 32 DI 10.4161/hv.26731 PG 8 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AH6RQ UT WOS:000336258800004 PM 24104203 ER PT J AU Leung, J Siegel, S Jones, JF Schulte, C Blog, D Schmid, DS Bialek, SR Marin, M AF Leung, Jessica Siegel, Subhadra Jones, James F. Schulte, Cynthia Blog, Debra Schmid, D. Scott Bialek, Stephanie R. Marin, Mona TI Fatal varicella due to the vaccine-strain varicella-zoster virus SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE varicella; VZV; varicella-zoster virus; vaccine-strain; vaccine adverse event; acyclovir resistance ID INFECTIOUS-DISEASES SOCIETY; HIV MEDICINE ASSOCIATION; INSTITUTES-OF-HEALTH; KILLER T-CELLS; OPPORTUNISTIC INFECTIONS; SAFETY PROFILE; UNITED-STATES; CHILD; ACYCLOVIR; RECOMMENDATIONS AB We describe a death in a 15-mo-old girl who developed a varicella-like rash 20 d after varicella vaccination that lasted for 2 mo despite acyclovir treatment. The rash was confirmed to be due to vaccine-strain varicella-zoster virus (VZV). This is the first case of fatal varicella due to vaccine-strain VZV reported from the United States. The patient developed severe respiratory complications that worsened with each new crop of varicella lesions; vaccine-strain VZV was detected in the bronchial lavage specimen. Sepsis and multi-organ failure led to death. The patient did not have a previously diagnosed primary immune deficiency, but her failure to thrive and repeated hospitalizations early in life (starting at 5 mo) for presumed infections and respiratory compromise treated with corticosteroids were suggestive of a primary or acquired immune deficiency. Providers should monitor for adverse reactions after varicella vaccination. If severe adverse events develop, acyclovir should be administered as soon as possible. The possibility of acyclovir resistance and use of foscar-net should be considered if lesions do not improve after 10 d of treatment (or if they become atypical [e. g., verrucous]). Experience with use of varicella vaccine indicates that the vaccine has an excellent safety profile and that serious adverse events are very rare and mostly described in immunocompromised patients. The benefit of vaccination in preventing severe disease and mortality outweigh the low risk of severe events occurring after vaccination. C1 [Leung, Jessica; Schmid, D. Scott; Bialek, Stephanie R.; Marin, Mona] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Siegel, Subhadra] New York Med Coll, Dept Pediat, New York, NY USA. [Jones, James F.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Schulte, Cynthia; Blog, Debra] New York State Dept Hlth, Bur Immunizat, Albany, NY USA. RP Leung, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM JLeung@cdc.gov NR 34 TC 10 Z9 10 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JAN PY 2014 VL 10 IS 1 BP 146 EP 149 DI 10.4161/hv.26200 PG 4 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AH6RQ UT WOS:000336258800022 PM 23982221 ER PT J AU Caraballo, RS Wang, X Xu, X AF Caraballo, Ralph S. Wang, Xu Xu, Xin TI Can you refuse these discounts? An evaluation of the use and price discount impact of price-related promotions among US adult smokers by cigarette manufacturers SO BMJ OPEN LA English DT Article ID 4 COUNTRY SURVEY; SMOKING-CESSATION; PURCHASE PATTERNS; TOBACCO; BEHAVIORS AB Objectives: The raising unit price of cigarette has been shown to be one of the most effective ways of reducing cigarette consumption and increasing rates of successful quitting. However, researchers have shown that price-sensitive smokers have used a variety of strategies to mitigate the effect of the rising price of cigarettes on their smoking habits. In particular, 23-34% of adult smokers in the US use cheaper brands, and 18-55% use coupons or promotions. Little is known about the discount use by type of brands. As such, the main purpose of this analysis is to evaluate the uses and price discount effects of these price-related discounts by manufacturers and major brands. Setting: An analysis based on the cross-sectional 2009-2010 National Adult Tobacco Survey (NATS). Participants: 11 766 current smokers aged 18 or above in the USA. Primary outcome measures: Price-related discount was defined as smokers who used coupons, rebates, buy-one-get-one-free, two-for-one or any other special promotions for their last cigarettes purchase. Results: The use of price-related discounts and associated price impact vary widely by cigarette manufacturer and brand. Approximately one of three Camel, one of four Marlboro and one of eight Newport smokers used price-related discounts on their latest cigarette purchases. The average price reductions of discounts offered by Philip Morris (PM) or R.J. Reynolds (RJR) were around 29 cents per pack while that of Lorillard (Newport only) was 24 cents per pack. Cigarette brands that provided significant per pack price reductions include: PM Marlboro (28 cents), RJR brand Camel (41 cents), Doral (50 cents), Kool (73 cents) and Salem (80 cents), and Lorillard Newport (24 cents). Conclusions: Policies that decrease price-minimisation strategies will benefit public health. C1 [Caraballo, Ralph S.; Wang, Xu; Xu, Xin] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30333 USA. RP Caraballo, RS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30333 USA. EM rfc8@cdc.gov NR 25 TC 4 Z9 4 U1 2 U2 4 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-6055 J9 BMJ OPEN JI BMJ Open PY 2014 VL 4 IS 6 AR e004685 DI 10.1136/bmjopen-2013-004685 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AM2YH UT WOS:000339717100025 PM 24898086 ER PT J AU Spradling, PR Hu, DJ McMahon, BJ AF Spradling, Philip R. Hu, Dale J. McMahon, Brian J. BE Thomas, HC Lok, ASF Locarnini, SA Zuckerman, AJ TI Epidemiology and prevention SO VIRAL HEPATITIS, 4TH EDITION LA English DT Article; Book Chapter ID HEPATITIS-B-VIRUS; HEPATOCELLULAR-CARCINOMA; UNITED-STATES; INFECTION; VACCINATION; GENOTYPE; CHILDREN; IMMUNITY; TAIWAN; AGE AB Infection with hepatitis B virus (HBV) continues to be a leading cause of illness and death in many areas of the world. The prevalence of chronic infection among countries varies greatly and remains high in many parts of Asia and Africa. In developed countries, the prevalence is higher among those who emigrated from high- or intermediate-prevalence countries and among those with high-risk behaviors. Since the release of a highly effective vaccine in 1981, universal infant hepatitis B vaccination programs implemented in a growing number of countries have resulted in dramatic reductions in perinatal and chronic infection. Among persons vaccinated during adolescence and adulthood, studies demonstrate persistence of immunity for at least 20 years, and revaccination (or "booster doses") is not recommended. However, among persons vaccinated at birth, some data suggest loss of immunity in a significant proportion of persons after 15 years. Studies are ongoing to examine long-term immunity among persons who received hepatitis B vaccine at birth to determine if, when, and for whom revaccination may be warranted. Hepatitis B virus (HBV) is a significant global pathogen. Approximately one-third of the world's population has been exposed to this virus, and 240 million persons are estimated to have chronic HBV infection. In the United States, the overall prevalence of chronic HBV infection is nearly 0.3%, but it is approximately 10% among persons born in countries in which hepatitis B is endemic. In this chapter, we review the epidemiology of hepatitis B in the United States and the rest of the world, including the routes of HBV transmission, groups and settings in which the risk of HBV infection is high, and HBV co-infection with other viruses. We also discuss prevention of HBV infection with hepatitis B vaccines and their global impact on this viral infection. C1 [Spradling, Philip R.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Hu, Dale J.] US Embassy, US CDC Off, Int Emerging Infect Program, Beijing, Peoples R China. [McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA. [McMahon, Brian J.] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA. RP Spradling, PR (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. NR 36 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND BN 978-0-470-67295-2 PY 2014 BP 81 EP 95 PG 15 WC Gastroenterology & Hepatology; Infectious Diseases; Virology SC Gastroenterology & Hepatology; Infectious Diseases; Virology GA BA5VL UT WOS:000337034100007 ER PT J AU Farley, JE Landers, TF Godfrey, C Lipke, V Sugarman, J AF Farley, Jason E. Landers, Timothy F. Godfrey, Catherine Lipke, Virginia Sugarman, Jeremy TI Optimizing the Protection of Research Participants and Personnel in HIV-Related Research Where TB Is Prevalent: Practical Solutions for Improving Infection Control SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE infection control; TB; HIV; clinical research; human subjects protections; ethics ID DRUG-RESISTANT TUBERCULOSIS; ISONIAZID PREVENTIVE THERAPY; HEALTH-CARE WORKERS; SOUTH-AFRICA; PULMONARY TUBERCULOSIS; ANTIRETROVIRAL THERAPY; MULTIDRUG-RESISTANT; TRANSMISSION; IMPLEMENTATION; DISINFECTION AB Tuberculosis (TB) is a leading cause of death among persons with HIV globally. HIV-related research in TB endemic areas raises some unique and important ethical issues in infection control related to protecting both research participants and personnel. To address such concerns, this article provides practical guidance to help research teams develop strategies to prevent TB transmission in studies involving persons with HIV in TB endemic settings. C1 [Farley, Jason E.] Johns Hopkins Univ, Sch Nursing, Dept Community & Publ Hlth, Baltimore, MD 21205 USA. [Farley, Jason E.; Sugarman, Jeremy] Johns Hopkins Ctr AIDS Res CFAR, Baltimore, MD USA. [Landers, Timothy F.] Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA. [Godfrey, Catherine] NIAID, NIH, Bethesda, MD 20892 USA. [Lipke, Virginia] Ctr Dis Control & Prevent, Div Global HIV AIDS GAP, Atlanta, GA USA. [Sugarman, Jeremy] Johns Hopkins Berman Inst Bioeth, Baltimore, MD USA. [Sugarman, Jeremy] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. RP Farley, JE (reprint author), Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St,Suite 525, Baltimore, MD 21205 USA. EM jfarley1@jhu.edu FU National Institutes of Health (NIH) [1P30AI094189]; NIH - National Institute of Allergy and Infectious Disease; NIH - NCI; NIH - National Institute of Child Health and Human Development; NIH - National Heart, Lung, and Blood Institute; NIH - National Institute of Drug Abuse; NIH - National Institute of Mental Health; NIH - National Institute on Aging; NIH - FIC; NIH - OAR; National Institute of Allergy and Infectious Disease; National Institute of Drug Abuse; National Institute of Mental Health [UM1AI068619] FX This publication proposal was made possible with help from the Johns Hopkins University Center for AIDS Research, a National Institutes of Health (NIH)-funded program (1P30AI094189), which is supported by the following NIH cofunding and participating Institutes and Centers: National Institute of Allergy and Infectious Disease, NCI, National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Institute of Drug Abuse, National Institute of Mental Health, National Institute on Aging, FIC, and OAR. Work on this article was also supported in part by the National Institute of Allergy and Infectious Disease, National Institute of Drug Abuse and the National Institute of Mental Health under Cooperative Agreement # UM1AI068619 to the HIV Prevention Trials Network. NR 40 TC 2 Z9 2 U1 1 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2014 VL 65 SU 1 BP S19 EP S23 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AL3IF UT WOS:000339019600006 PM 24321979 ER PT J AU Cassell, MM Holtz, TH Wolfe, MI Hahn, M Prybylski, D AF Cassell, Michael M. Holtz, Timothy H. Wolfe, Mitchell I. Hahn, Michael Prybylski, Dimitri TI 'Getting to zero' in Asia and the Pacific through more strategic use of antiretrovirals for HIV prevention SO SEXUAL HEALTH LA English DT Review DE AIDS; at-risk populations; epidemic; pre-exposure prophylaxis; treatment as prevention ID SEXUALLY-TRANSMITTED INFECTIONS; HUMAN-IMMUNODEFICIENCY-VIRUS; INJECTION-DRUG USERS; FEMALE SEX WORKERS; RANDOMIZED-TRIAL; CONDOM USE; PREEXPOSURE PROPHYLAXIS; DEVELOPING-COUNTRIES; NEXT-GENERATION; RISK BEHAVIORS AB Encouraged by experimental trials demonstrating the efficacy of antiretrovirals (ARVs) in preventing HIV infection, countries across the Asia-Pacific region have committed to the achievement of ambitious targets tantamount to ending AIDS. The available data suggest that some countries still can make progress through targeted condom promotion and the expansion of harm-reduction interventions, but that none may realise its vision of 'zero new HIV infections' without more strategic use of ARVs as part of a combination of HIV prevention efforts targeting key populations. Low rates of HIV testing among men who have sex with men, people who inject drugs, sex workers and other key populations evidence low treatment coverage where treatment could have the greatest impact on curbing local epidemics. Studies have demonstrated the promise of adding ARV treatment and pre-exposure prophylaxis to the existing HIV prevention toolkit, but achieving population-level impact will require service-delivery approaches that overcome traditional prevention, care and treatment program distinctions. Priorities include: (1) innovative strategies to reach, test, treat and retain in services the individuals most likely to acquire or transmit HIV; (2) task shifting and enhanced partnerships between the public sector and civil society; (3) improved 'cascade' data systems to assess and promote service uptake and retention; and (4) policy and financing reform to enhance HIV testing and treatment access among key populations. C1 [Cassell, Michael M.] US Agcy Int Dev, Hanoi, Vietnam. [Holtz, Timothy H.; Wolfe, Mitchell I.; Prybylski, Dimitri] Minist Publ Hlth, Dept Dis Control, Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Nonthaburi 11000, Thailand. [Holtz, Timothy H.] US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Wolfe, Mitchell I.; Prybylski, Dimitri] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Hahn, Michael] Joint United Nations Programme HIV AIDS, Thailand Country Off, Pranakorn Bangkok 10200, Thailand. RP Cassell, MM (reprint author), US Agcy Int Dev, 6th Floor,Tung Shing Sq,2 Ngo Quyen, Hanoi, Vietnam. EM mcassell@usaid.gov NR 102 TC 4 Z9 4 U1 6 U2 10 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2014 VL 11 IS 2 BP 107 EP 118 DI 10.1071/SH13116 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AL3CD UT WOS:000339002000004 PM 24942266 ER PT S AU Hamner, HC Tinker, SC AF Hamner, Heather C. Tinker, Sarah C. BE PenaRosas, JP GarciaCasal, MN Pachon, H TI Fortification of corn masa flour with folic acid in the United States: an overview of the evidence SO TECHNICAL CONSIDERATIONS FOR MAIZE FLOUR AND CORN MEAL FORTIFICATION IN PUBLIC HEALTH SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT World-Health-Organization Consultation on Technical Considerations for Fortification of Maize Flour and Corn Meal in Public Health CY APR 08-09, 2013 CL New York Acad Sci, New York, NY SP World Hlth Org, Flour Fortificat Initiat HO New York Acad Sci DE fortification; corn masa flour; folic acid ID NEURAL-TUBE DEFECTS; NUTRITION EXAMINATION SURVEY; MEXICAN-AMERICAN WOMEN; ACCULTURATION FACTORS; POTENTIAL IMPACT; NATIONAL-HEALTH; PREVENTION; POPULATION; VITAMIN; FOLATE AB Corn masa flour, used to make products such as corn tortillas, is a staple food for Hispanic populations residing in the United States, particularly among Mexican Americans and Central Americans. Research has indicated that Hispanic women in the United States continue to be at a higher risk of having a neural tube defect-affected pregnancy than women of other races/ethnicities, even after the introduction of folic acid fortification of cereal grain products labeled as "enriched." Corn masa flour has, therefore, been suggested as a potential food vehicle for folic acid in the United States. This paper explores the potential impact that folic acid fortification of corn masa flour could have on the Hispanic population in the United States. C1 [Hamner, Heather C.; Tinker, Sarah C.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Hamner, HC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE MS E-86, Atlanta, GA 30333 USA. EM hfc2@cdc.gov FU Sackler Institute for Nutrition Science at the New York Academy of Sciences; FFI FX The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. This article was presented at the World Health Organization consultation "Technical Considerations for Maize Flour and Corn Meal Fortification in PublicHealth" in collaboration with the Sackler Institute for Nutrition Science at the New York Academy of Sciences and the Flour Fortification Initiative (FFI), convened on 8 and 9 April 2013, at the New York Academy of Sciences in New York, USA. This article is being published individually but will be consolidated with other articles as a special issue of Annals of the New York Academy of Sciences. The coordinators of this issue were Drs. Maria Nieves Garcia-Casal, Mireille McLean, Helena Pachon, and Juan Pablo Pena-Rosas. The special issue is the responsibility of the editorial staff of Annals of the New York Academy of Sciences, who delegated to the coordinators preliminary supervision of both technical conformity to the publishing requirements of Annals of the New York Academy of Sciences and general oversight of the scientific merit of each article. The workshop was supported by the Sackler Institute for Nutrition Science at the New York Academy of Sciences and the FFI. The authors alone are responsible for the views expressed in this article; they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated or the decisions, policies, or views of the World Health Organization. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors, publisher, or editorial staff of Annals of the New York Academy of Sciences. NR 32 TC 4 Z9 4 U1 3 U2 17 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2014 VL 1312 BP 8 EP 14 DI 10.1111/nyas.12325 PG 7 WC Food Science & Technology; Public, Environmental & Occupational Health; Nutrition & Dietetics SC Food Science & Technology; Public, Environmental & Occupational Health; Nutrition & Dietetics GA BA8PR UT WOS:000338446900002 PM 24494975 ER PT J AU Bean, CJ Hooper, WC Ellingsen, D DeBaun, MR Sonderman, J Blot, WJ AF Bean, Christopher J. Hooper, W. Craig Ellingsen, Dorothy DeBaun, Michael R. Sonderman, Jennifer Blot, William J. TI Discordance between Self-Report and Genetic Confirmation of Sickle Cell Disease Status in African-American Adults SO PUBLIC HEALTH GENOMICS LA English DT Article DE Genetic communication; Health literacy; Hemoglobin; Self-report; Sickle cell disease ID PUBLIC-HEALTH IMPLICATIONS; TRAIT; KNOWLEDGE; ATTITUDES; AWARENESS; BELIEFS AB Background: Sickle cell disease (SCD) is an autosornal recessive genetic disorder, with persons heterozygous for the mutation said to have the sickle cell trait (SCT). Serious adverse effects are mainly limited to those with SCD, but the distinction between disease and trait is not always clear to the general population. We sought to determine the accuracy of self-reported SCD when compared to genetic confirmation. Methods: From stratified random samples of Southern Community Cohort Study participants, we sequenced the beta-globin gene in 51 individuals reporting SCD and 75 individuals reporting no SCD. Results: The median age of the group selected was 53 years (range 40-69) with 29% male. Only 5.9% of the 51 individuals reporting SCD were confirmed by sequencing, with the remaining 62.7% having SCT, 5.9% having hemoglobin C trait, and 25.5% having neither SCD nor trait. Sequencing results of the 75 individuals reporting no SCD by contrast were 100% concordant with self-report. Conclusions: Misreporting of SCD is common in an older adult population, with most persons reporting SCD in this study being carriers of the trait and a sizeable minority completely unaffected. The results from this pilot survey support the need for increased efforts to raise community awareness and knowledge of SCD. (C) 2014 S. Karger AG, Basel C1 [Bean, Christopher J.; Hooper, W. Craig; Ellingsen, Dorothy] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA USA. [DeBaun, Michael R.] Vanderbilt Meharry Matthew Walker Ctr Excellence, Nashville, TN 37208 USA. [Blot, William J.] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN 37232 USA. [Sonderman, Jennifer; Blot, William J.] Int Epidemiol Inst, Rockville, MD USA. RP Blot, WJ (reprint author), Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, 1161 21st Ave S, Nashville, TN 37232 USA. EM william.j.blot@vanderbilt.edu FU Intramural CDC HHS [CC999999]; NCI NIH HHS [R01 CA092447] NR 18 TC 3 Z9 3 U1 1 U2 4 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 EI 1662-8063 J9 PUBLIC HEALTH GENOM JI Pub. Health Genomics PY 2014 VL 17 IS 3 BP 169 EP 172 DI 10.1159/000360260 PG 4 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA AK9NZ UT WOS:000338755100006 PM 24685557 ER PT J AU Lopez, LM Grimes, DA Schulz, KF Curtis, KM Chen, M AF Lopez, Laureen M. Grimes, David A. Schulz, Kenneth F. Curtis, Kathryn M. Chen, Mario TI Steroidal contraceptives: effect on bone fractures in women SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Bone Density [drug effects]; Bone Remodeling [drug effects]; Contraceptives, Oral, Hormonal [adverse effects; pharmacology]; Estrogens [pharmacology]; Fractures, Bone [chemically induced]; Medroxyprogesterone Acetate [adverse effects; pharmacology]; Premenopause; Progestins [pharmacology]; Randomized Controlled Trials as Topic; Female; Humans ID DEPOT MEDROXYPROGESTERONE ACETATE; COMBINED ORAL-CONTRACEPTIVES; RANDOMIZED CONTROLLED-TRIAL; YOUNG FERTILE WOMEN; MINERAL DENSITY; HORMONAL CONTRACEPTION; ADOLESCENT GIRLS; DOUBLE-BLIND; LEVONORGESTREL; TURNOVER AB Background Steroidal contraceptive use has been associated with changes in bone mineral density in women. Whether such changes increase the risk of fractures later in life is not clear. Osteoporosis is a major public health concern. Age-related decline in bone mass increases the risk of fracture, especially of the spine, hip, and wrist. Concern about bone health influences the recommendation and use of these effective contraceptives globally. Objectives Our aim was to evaluate the effect of using hormonal contraceptives before menopause on the risk of fracture in women. Search methods Through April 2014, we searched for studies of fracture or bone health and hormonal contraceptives in MEDLINE, POPLINE, CENTRAL, EMBASE, and LILACS, as well as ClinicalTrials.gov and ICTRP. We examined reference lists of relevant articles for other trials. For the initial review, we wrote to investigators to find additional trials. Selection criteria Randomized controlled trials (RCTs) were considered if they examined fractures, bone mineral density (BMD), or bone turnover markers in women with hormonal contraceptive use prior to menopause. Eligible interventions included comparisons of a hormonal contraceptive with a placebo or with another hormonal contraceptive that differed in terms of drug, dosage, or regimen. They also included providing a supplement to one group. Data collection and analysis We assessed all titles and abstracts identified through the literature searches. Mean differences were computed using the inverse variance approach. For dichotomous outcomes, theMantel-Haenszel odds ratio (OR) was calculated. Both included the 95% confidence interval (CI) and used a fixed-effect model. Due to differing interventions, no trials could be combined for meta-analysis. We applied principles from GRADE to assess the evidence quality and address confidence in the effect estimates. In addition, a sensitivity analysis included trials that provided sufficient data for this review and evidence of at least moderate quality. Main results We found 19RCTs that met our eligibility criteria. Eleven trials compared different combined oral contraceptives (COCs) or regimens of COCs; five examined an injectable versus another injectable, implant, or IUD; two studied implants, and one compared the transdermal patch versus the vaginal ring. No trial had fracture as an outcome. BMD was measured in 17 studies and 12 trials assessed biochemical markers of bone turnover. Depot medroxyprogesterone acetate (DMPA) was associated with decreased bone mineral density (BMD). The placebo-controlled trials showed BMD increases for DMPA plus estrogen supplement and decreases for DMPA plus placebo supplement. COCs did not appear to negatively affect BMD, and some formulations had more positive effects than others. However, no COC trial was placebo-controlled. Where studies showed differences between groups in bone turnover markers, the results were generally consistent with those for BMD. For implants, the single-rod etonogestrel group showed a greater BMD decrease versus the two-rod levonorgestrel group but results were not consistent across all implant comparisons. The sensitivity analysis included 11 trials providing evidence of moderate or high quality. Four trials involving DMPA showed some positive effects of an estrogen supplement on BMD, a negative effect of DMPA-subcutaneous on lumbar spine BMD, and a negative effect of DMPA on a bone formation marker. Of the three COC trials, one had a BMD decrease for the group with gestodene plus EE 15 mu g. Another indicated less bone resorption in the group with gestodene plus EE 30 mu g versus EE 20 mu g. Authors' conclusions Whether steroidal contraceptives influence fracture risk cannot be determined from existing information. The evidence quality was considered moderate overall, largely due to the trials of DMPA, implants, and the patch versus ring. The COC evidence varied in quality but was low overall. Many trials had small numbers of participants and some had large losses. Health care providers and women should consider the costs and benefits of these effective contraceptives. For example, injectable contraceptives and implants provide effective, long-term birth control yet do not involve a daily regimen. Progestin-only contraceptives are considered appropriate for women who should avoid estrogen due to medical conditions. C1 [Lopez, Laureen M.] FHI 360, Clin Sci, Durham, NC 27701 USA. [Grimes, David A.; Schulz, Kenneth F.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Schulz, Kenneth F.] FHI 360, Quantitat Sci, Durham, NC USA. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Chen, Mario] FHI 360, Div Biostat, Durham, NC USA. RP Lopez, LM (reprint author), FHI 360, Clin Sci, 359 Blackwell St,Suite 200, Durham, NC 27701 USA. EM llopez@fhi360.org FU National Institute of Child Health and Human Development, USA.; US Agency for International Development, USA. FX Internal sources; No sources of support supplied; External sources; National Institute of Child Health and Human Development, USA.; Support for conducting the review and updates at FHI 360 (through 2014); US Agency for International Development, USA. NR 76 TC 5 Z9 5 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2014 IS 6 AR CD006033 DI 10.1002/14651858.CD006033.pub5 PG 93 WC Medicine, General & Internal SC General & Internal Medicine GA AK3FM UT WOS:000338308700022 PM 24960023 ER PT J AU Razzaghi, H Tinker, SC AF Razzaghi, Hilda Tinker, Sarah C. TI Seafood consumption among pregnant and non-pregnant women of childbearing age in the United States, NHANES 1999-2006 SO FOOD & NUTRITION RESEARCH LA English DT Article DE pregnant; fish; seafood; NHANES; mercury ID MATERNAL FISH INTAKE; PROSPECTIVE COHORT; US COHORT; METHYLMERCURY; EXPOSURE; OUTCOMES; CHILDREN; MERCURY; CHILDHOOD; COGNITION AB Objectives: Long-chain polyunsaturated fatty acids found in seafood are essential for optimal neurodevelopment of the fetus. However, concerns about mercury contamination of seafood and its potential harm to the developing fetus have created uncertainty about seafood consumption for pregnant women. We compared fish and shellfish consumption patterns, as well as their predictors, among pregnant and non-pregnant women of childbearing age in the US. Methods: Data from 1,260 pregnant and 5,848 non-pregnant women aged 16-49 years from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES) were analyzed. Frequency and type of seafood consumed and adjusted associations of multiple characteristics with seafood consumption were estimated for pregnant and non-pregnant women, separately. Time trends were also examined. Results: There were no significant differences in the prevalence of fish or shellfish consumption, separately or combined, between pregnant and non-pregnant women using either the 30-day questionnaire or the Day 1, 24-h recall. Seafood consumption was associated with higher age, income, and education among pregnant and non-pregnant women, and among fish consumers these groups were more likely to consume >= 3 servings in the past 30 days. Tuna and shrimp were the most frequently reported fish and shellfish, respectively, among both pregnant and non-pregnant women. We observed no significant time trends. Conclusion: There were no differences in seafood consumption between pregnant and non-pregnant women, and the factors related to seafood consumption were similar for both groups. Our data suggest that many women consume less than the recommended two servings of seafood a week. C1 [Razzaghi, Hilda; Tinker, Sarah C.] CDC, Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Razzaghi, H (reprint author), 1600 Clifton Rd,Mail Stop E86, Atlanta, GA 30345 USA. EM hir2@cdc.gov FU appointment to the Research Participation program for the Centers for Disease Control and Prevention FX H.R. was supported by an appointment to the Research Participation program for the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an agreement between the Department of Energy and CDC. NR 31 TC 1 Z9 1 U1 0 U2 6 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1654-6628 EI 1654-661X J9 FOOD NUTR RES JI Food Nutr. Res. PY 2014 VL 58 AR 23287 DI 10.3402/fnr.v58.23287 PG 9 WC Food Science & Technology; Nutrition & Dietetics SC Food Science & Technology; Nutrition & Dietetics GA AK3UJ UT WOS:000338349900001 ER PT J AU Lee, SJ Tak, S Alterman, T Calvert, GM AF Lee, Soo-Jeong Tak, Sangwoo Alterman, Toni Calvert, Geoffrey M. TI Prevalence of Musculoskeletal Symptoms Among Agricultural Workers in the United States: An Analysis of the National Health Interview Survey, 2004-2008 SO JOURNAL OF AGROMEDICINE LA English DT Article DE Agriculture; joint pain; low back pain; musculoskeletal symptoms; national survey ID BACK-PAIN; FARMERS; DISORDERS; RISK; SURVEILLANCE; ILLNESS; MIGRANT; INJURY AB Ergonomic risks from agricultural tasks can compromise musculoskeletal health of workers. This study estimated prevalence of musculoskeletal symptoms in a sample representing almost 2 million US agricultural industry workers. This study used National Health Interview Survey data from 2004 to 2008. Weighted prevalence was calculated by demographic and employment factors. Prevalence ratios were calculated using generalized linear models with the Poisson distribution assumption. Prevalence rates of low back and neck pain in the previous 3 months were 24.3% and 10.5%, respectively, among agricultural workers. Monthly prevalence of joint pain was 17.0% for hips/knees, 9.8% for shoulders, 9.5% for wrists/hands, 5.4% for elbows, and 4.7% for ankles/toes. Agricultural workers had a significantly higher prevalence of shoulder pain than all other industry workers (prevalence ratios [PR] = 1.28, 95% confidence interval [CI]: 1.02-1.61). This study provides detailed national estimates of musculoskeletal symptom prevalence to understand the burden and the need for intervention among agricultural workers. C1 [Lee, Soo-Jeong] Univ Calif San Francisco, Sch Nursing, Dept Community Hlth Syst, San Francisco, CA 94143 USA. [Tak, Sangwoo] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA. [Alterman, Toni; Calvert, Geoffrey M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Lee, SJ (reprint author), Univ Calif San Francisco, Sch Nursing, Dept Community Hlth Syst, 2 Koret Way,Suite N505, San Francisco, CA 94143 USA. EM soo-jeong.lee@nursing.ucsf.edu OI Alterman, Toni/0000-0003-1512-4367 NR 40 TC 3 Z9 3 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1059-924X EI 1545-0813 J9 J AGROMEDICINE JI J. Agromedicine PY 2014 VL 19 IS 3 BP 268 EP 280 DI 10.1080/1059924X.2014.916642 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AJ9FO UT WOS:000338013300003 PM 24959759 ER PT J AU Lisko, JG Stanfill, SB Watson, CH AF Lisko, Joseph G. Stanfill, Stephen B. Watson, Clifford H. TI Quantitation of ten flavor compounds in unburned tobacco products SO ANALYTICAL METHODS LA English DT Article ID CHROMATOGRAPHY-MASS SPECTROMETRY; COUMARIN; CAMPHOR; ALKENYLBENZENES; CIGARETTES; MENTHOL; SMOKE AB Most research on unburned tobacco has focused on the harmful chemicals associated with the tobacco itself. However, certain flavor additives in tobacco products can pose additional health risks. Flavors like camphor, coumarin, pulegone, eugenol, methyl salicylate, menthol and diphenyl ether have exhibited biological activity and/or toxicity in both lab animals and humans. This publication presents a new GC/MS method for the quantitation of ten flavor compounds (eucalyptol, camphor, menthol, pulegone, ethyl salicylate, methyl salicylate, cinnamaldehyde, eugenol, diphenyl ether and coumarin) in a variety of tobacco products, including smokeless products and cigar filler. Excellent linearity (>0.997), accuracy (93.9-106.6%) and precision (CV, 0.5-3.0%) were achieved for all flavor analytes measured. A summary of the concentrations of these flavors in selected international smokeless tobacco (SLT) products including zarda, quiwam, gutkha, and khaini varieties from Southeast Asia and snuff, clove cigarette filler and flavored cigar filler from the United States is reported. High concentrations of eugenol (2110 mu g g(-1)), coumarin (439 mu g g(-1)), camphor (1060 mu g g(-1)) and diphenyl ether (4840 mu g g(-1)) were found in selected products. Accurate identification and quantitation of potentially hazardous flavor compounds is important because they can exist in relatively high levels in some tobacco products, including international SLT products. We outline a versatile method which can be used to quantitate flavor compounds in multiple types of tobacco products. C1 [Lisko, Joseph G.; Stanfill, Stephen B.; Watson, Clifford H.] Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Lisko, JG (reprint author), Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway, Atlanta, GA 30341 USA. EM jlisko@cdc.gov FU Intramural CDC HHS [CC999999] NR 29 TC 5 Z9 6 U1 0 U2 14 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2014 VL 6 IS 13 BP 4698 EP 4704 DI 10.1039/c4ay00271g PG 7 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA AJ5XI UT WOS:000337763200031 PM 26388954 ER PT J AU Wang, Y Chen, AM Dietrich, KN Radcliffe, J Caldwell, KL Rogan, WJ AF Wang, Yan Chen, Aimin Dietrich, Kim N. Radcliffe, Jerilynn Caldwell, Kathleen L. Rogan, Walter J. TI Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States SO CHILD NEUROPSYCHOLOGY LA English DT Article DE Methyl mercury; Lead; Postnatal exposure; Neuropsychological tests; Cognition; IQ ID PRENATAL METHYLMERCURY EXPOSURE; POLYUNSATURATED FATTY-ACIDS; CHELATION-THERAPY; CHILDBEARING AGE; FISH CONSUMPTION; MATERNAL FISH; US CHILDREN; BLOOD LEAD; PREGNANCY; NEURODEVELOPMENT AB Background: The most common route for general population exposure to methyl mercury (MeHg) is fish consumption. Recommendations to pregnant women about consuming fish contaminated with MeHg are also applied to children, but there are few studies available about the effects of low-level postnatal MeHg exposure in them.Objectives: To investigate the association between postnatal methyl mercury exposure and neuropsychological development in a study of children also exposed to lead, both measured at 7 years.Methods: We measured MeHg concentrations in blood samples from the Treatment of Lead-Exposed Children (TLC) trial in which 780 children with elevated concentrations of lead in blood were followed with neuropsychological tests from ages 12-33 months through 7 years. Here we examine blood MeHg concentration and neuropsychological test scores, both measured at age 7 years. We used a maximum likelihood method to estimate geometric mean MeHg concentration and generalized linear regression models to analyze MeHg and neuropsychological test scores.Results: Geometric mean MeHg concentration was 0.56 (95% confidence interval: 0.52, 0.59) g/L. A1g/L increase in MeHg was associated with a 2.1 (95% confidence interval: 0.4, 3.8) point increase in Full-Scale IQ and 0.2 (95% confidence interval: 0.02, 0.4) point increase in Learning Slopeindex T-score on a test of verbal memory.Conclusions: Our results suggest that the relatively low MeHg exposure in US school-aged children from this population has no detectable adverse effect on neuropsychological development. The positive associations observed between MeHg and neurodevelopment may indirectly reflect consumption of beneficial polyunsaturated fatty acids from seafood. C1 [Wang, Yan; Rogan, Walter J.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA. [Chen, Aimin; Dietrich, Kim N.] Univ Cincinnati, Coll Med, Div Epidemiol & Biostat, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Radcliffe, Jerilynn] Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Caldwell, Kathleen L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Inorgan & Radiat Analyt Toxicol Branch, Atlanta, GA USA. RP Dietrich, KN (reprint author), Univ Cincinnati, Coll Med, Div Epidemiol & Biostat, Dept Environm Hlth, 3223 Eden Ave,Room G-31,ML 056, Cincinnati, OH 45267 USA. EM kim.dietrich@uc.edu RI Rogan, Walter/I-6034-2012 OI Rogan, Walter/0000-0002-9302-0160 FU US National Institute of Environmental Health Sciences/National Institutes of Health FX This study was supported by the Intramural Research Program of the US National Institute of Environmental Health Sciences/National Institutes of Health. We thank Dr. Robert Jones, National Center for Environmental Health of the CDC, for help with the measurement of Hg and the editorial assistance of NIH Fellows Editorial Board. NR 37 TC 2 Z9 2 U1 0 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0929-7049 EI 1744-4136 J9 CHILD NEUROPSYCHOL JI Child Neuropsychol. PY 2014 VL 20 IS 5 BP 527 EP 538 DI 10.1080/09297049.2013.824955 PG 12 WC Clinical Neurology SC Neurosciences & Neurology GA AJ8QE UT WOS:000337970600003 PM 23971942 ER PT J AU Margos, G Piesman, J Lane, RS Ogden, NH Sing, A Straubinger, RK Fingerle, V AF Margos, Gabriele Piesman, Joseph Lane, Robert S. Ogden, Nicholas H. Sing, Andreas Straubinger, Reinhard K. Fingerle, Volker TI Borrelia kurtenbachii sp nov., a widely distributed member of the Borrelia burgdorferi sensu lato species complex in North America SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID MULTILOCUS SEQUENCE-ANALYSIS; LYME-DISEASE; BISSETTII; SURVEILLANCE; INFECTION; GENETICS; REVEALS; STRAINS; CANADA AB Lyme borreliosis group spirochaetes are parasitic bacteria transmitted by vector ticks of the genus lxodes and distributed mainly between 40 degrees and 60 degrees northern latitudes. Since Borrelia burgdorferi sensu stricto (hereinafter, B. burgdorferi) was described in the north-eastern USA during the early 1980s, an increasing diversity has been noted within the species complex. Here, we describe a novel genomic species, Borrelia kurtenbachii sp. nov. (type strain 25015(T)=ATCC BAA-2495(T)= DSM 26572(T)), that is prevalent in transmission cycles among vector ticks and reservoir hosts in North America. Confirmation of the presence of this species in Europe awaits further investigation. C1 [Margos, Gabriele; Straubinger, Reinhard K.] Univ Munich, Dept Infect Dis & Zoonoses, Fac Vet Med, D-80359 Munich, Germany. [Margos, Gabriele; Fingerle, Volker] Natl Reference Ctr Borrelia, D-85764 Oberschleissheim, Germany. [Margos, Gabriele; Sing, Andreas; Fingerle, Volker] Bavarian Hlth & Food Safety Author, D-85764 Oberschleissheim, Germany. [Piesman, Joseph] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Lane, Robert S.] Univ Calif Berkeley, Div Organisms & Environm, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Ogden, Nicholas H.] Publ Hlth Agcy Canada, Zoonoses Div, Ctr Food Borne Environm & Zoonot Infect Dis, Ottawa, ON, Canada. RP Margos, G (reprint author), Univ Munich, Dept Infect Dis & Zoonoses, Fac Vet Med, Vet Str 13, D-80359 Munich, Germany. EM gabriele.margos@lgl.bayern.de OI Fingerle, Volker/0000-0002-3835-5646; Straubinger, Reinhard/0000-0001-8382-7182 FU German National Reference Centre for Borrelia FX The authors are grateful for continuous support by the Bavarian Ministry for Environment and Health (StMUG) and the Robert Koch-Institut, Berlin, Germany, for support of the German National Reference Centre for Borrelia. In addition, the authors would like to thank D. Aanensen for maintaining the Borrelia MLST website at Imperial College London, UK; Nataljia Rudenko, Czech Academy of Sciences, and James Oliver of the James H. Oliver, Jr. Institute of Arthropodology and Parasitology (IAP), Georgia, USA, for sharing unpublished data. NR 23 TC 15 Z9 15 U1 1 U2 9 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 EI 1466-5034 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD JAN PY 2014 VL 64 BP 128 EP 130 DI 10.1099/ijs.0.054593-0 PN 1 PG 3 WC Microbiology SC Microbiology GA AJ8CN UT WOS:000337930400021 PM 24048870 ER PT J AU Fisher, EM Shaffer, RE AF Fisher, Edward M. Shaffer, Ronald E. TI Considerations for Recommending Extended Use and Limited Reuse of Filtering Facepiece Respirators in Health Care Settings SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Editorial Material ID PERSONAL PROTECTIVE EQUIPMENT; INFLUENZA-VIRUS; N95 RESPIRATORS; TRANSFER EFFICIENCY; INFECTION RISK; PANDEMIC H1N1; PARTICLE-SIZE; SURVIVAL; BACTERIA; IMPACT AB Public health organizations, such as the Centers for Disease Control and Prevention (CDC), are increasingly recommending the use of N95 filtering facepiece respirators (FFRs) in health care settings. For infection control purposes, the usual practice is to discard FFRs after close contact with a patient ("single use"). However, in some situations, such as during contact with tuberculosis patients, limited FFR reuse (i.e., repeated donning and doffing of the same FFR by the same person) is practiced. A related practice, extended use, involves wearing the same FFR for multiple patient encounters without doffing. Extended use and limited FFR reuse have been recommended during infectious disease outbreaks and pandemics to conserve FFR supplies. This commentary examines CDC recommendations related to FFR extended use and limited reuse and analyzes available data from the literature to provide a relative estimate of the risks of these practices compared to single use. Analysis of the available data and the use of disease transmission models indicate that decisions regarding whether FFR extended use or reuse should be recommended should continue to be pathogen-and event-specific. Factors to be included in developing the recommendations are the potential for the pathogen to spread via contact transmission, the potential that the event could result in or is currently causing a FFR shortage, the protection provided by FFR use, human factors, potential for self-inoculation, the potential for secondary exposures, and government policies and regulations. While recent findings largely support the previous recommendations for extended use and limited reuse in certain situations, some new cautions and limitations should be considered before issuing recommendations in the future. In general, extended use of FFRs is preferred over limited FFR reuse. Limited FFR reuse would allow the user a brief respite from extended wear times, but increases the risk of self-inoculation and preliminary data from one study suggest that some FFR models may begin to lose effectiveness after multiple donnings. C1 [Fisher, Edward M.; Shaffer, Ronald E.] NIOSH, Natl Personal Protect Technol Lab, Pittsburgh, PA 15236 USA. RP Shaffer, RE (reprint author), NIOSH, Technol Res Branch, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, 626 Cochrans Mill Rd,Bldg 20,POB 18070, Pittsburgh, PA 15236 USA. EM RShaffer@cdc.gov FU Intramural CDC HHS [CC999999] NR 100 TC 6 Z9 6 U1 1 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 8 BP D115 EP D128 DI 10.1080/15459624.2014.902954 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AJ8IM UT WOS:000337946700002 PM 24628658 ER PT B AU Weilharter, G AF Weilharter, Gottfried BE Scala, K Grossmann, R Lenglachner, M Mayer, K TI REFLECTIVE AND COMPETENT LEADERSHIP IN HOSPITALS THROUGH A DIFFERENTIATED CONCEPT OF CONSULTING SO LEADERSHIP LEARNING FOR THE FUTURE SE Research in Management Education and Development LA English DT Article; Book Chapter C1 CDC, Atlanta, GA 30333 USA. RP Weilharter, G (reprint author), CDC, Atlanta, GA 30333 USA. EM info@fritz-weilharter.at NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-62396-460-3; 978-1-62396-461-0 J9 RES MANAG EDUC DEV PY 2014 BP 319 EP 333 PG 15 WC Education & Educational Research; Management SC Education & Educational Research; Business & Economics GA BA5DL UT WOS:000336555000023 ER PT J AU Brett, ME Hinckley, AF Zielinski-Gutierrez, EC Mead, PS AF Brett, Meghan E. Hinckley, Alison F. Zielinski-Gutierrez, Emily C. Mead, Paul S. TI U.S. healthcare providers' experience with Lyme and other tick-borne diseases SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Tick-borne disease; Lyme disease; Treatment; Prophylaxis; Provider knowledge ID ERYTHEMA MIGRANS; ANTIBIOTIC-THERAPY; DIAGNOSIS; PREVENTION; PROPHYLAXIS; MANAGEMENT; MISSOURI; BITES AB Surveillance indicates that tick-borne diseases are a common problem in the United States. Nevertheless, little is known regarding the experience or management practices of healthcare providers who treat these conditions. The purpose of the present study was to characterize the frequency of tick-borne diseases in clinical practice and the knowledge of healthcare providers regarding their management. Four questions about tick-borne diseases were added to the 2009 Docstyles survey, a nationally representative survey of >2000 U.S. healthcare providers. Topics included diseases encountered, management of patients with early Lyme disease (LD), provision of tick-bite prophylaxis, and sources of information on tick-borne diseases. Overall, 51.3% of practitioners had treated at least one patient for a tick-borne illness in the previous year. Among these, 75.1% had treated one type of disease, 19.0% two types of disease, and 5.9% three or more diseases. LD was encountered by 936 (46.8%) providers; Rocky Mountain spotted fever was encountered by 184 (9.2%) providers. Given a scenario involving early LD, 89% of providers would prescribe antibiotics at the first visit, with or without ordering a blood test. Tick-bite prophylaxis was prescribed by 31.0% of all practitioners, including 41.1% in high-LD-incidence states and 26.0% in low-incidence states. Tick-borne diseases are encountered frequently in clinical practice. Most providers would treat early LD promptly, suggesting they are knowledgeable regarding the limitations of laboratory testing in this setting. Conversely, providers in low-LD-incidence states frequently prescribe tick-bite prophylaxis, suggesting a need for education to reduce potential misdiagnosis and overtreatment. Published by Elsevier GmbH. C1 [Brett, Meghan E.; Hinckley, Alison F.; Zielinski-Gutierrez, Emily C.; Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Hinckley, AF (reprint author), Ctr Dis Control & Prevent, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM ahinckley@cdc.gov FU Centers for Disease Control and Prevention FX This work was funded by the Centers for Disease Control and Prevention. The views expressed in the publication are those of the authors and not necessarily those of the U.S. government. The authors do not have any conflicts of interest to disclose. NR 24 TC 6 Z9 6 U1 1 U2 9 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2014 VL 5 IS 4 BP 404 EP 408 DI 10.1016/j.ttbdis.2014.01.008 PG 5 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA AJ9BO UT WOS:000338002000008 PM 24713280 ER PT J AU Krahn, GL Horner-Johnson, W Hall, TA Roid, GH Andresen, EM Fujiura, GT Nosek, MA Cardinal, BJ Drum, CE Suzuki, R Peterson, JJ AF Krahn, Gloria L. Horner-Johnson, Willi Hall, Trevor A. Roid, Gale H. Andresen, Elena M. Fujiura, Glenn T. Nosek, Margaret A. Cardinal, Bradley J. Drum, Charles E. Suzuki, Rie Peterson, Jana J. TI Development and Psychometric Assessment of the Function-Neutral Health-Related Quality of Life Measure SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article DE Persons with Disability; Health Status; Environment; Quality-of-Life; Questionnaires; Reliability; Validity ID SELF-RATED HEALTH; SPINAL-CORD-INJURY; DISABILITY PARADOX; PERCEIVED HEALTH; OUTCOMES; ADULTS; LIMITATIONS; ISSUES; SF-36 AB Objective: The aim of this study was to determine the conceptual framework, item pool, and psychometric properties of a new function-neutral measure of health-related quality-of-life (HRQOL). Design: This is an expert panel review of existing measures of HRQOL and development of a conceptual model, core constructs, and item pool and a validation by experts in specific disabilities and in cultural competence. Items were cognitively tested, pilot tested for functional bias, field tested with a national sample of adults with various limitations, and reliability tested via repeat administration. Final item selection was based on analyses of factor structure, demographic bias, variance in likelihood of endorsement, and item-total correlation. Psychometric properties were demonstrated through differential item functioning analyses, factor analyses, correlations, and item response theory analyses. Results: The results supported a four-domain conceptual model of HRQOL (physical health, mental health, social health, and life satisfaction and beliefs) for a 42-item HRQOL measure with an ancillary 15-item environment scale. The measure has strong internal consistency (alpha = 0.88-0.97), known-groups validity, and test-retest reliability (r = 0.83-0.91). Tests of convergent and divergent validity confirmed the ability of the Function-Neutral Health-Related Quality of Life to measure health while being relatively free of content assessing function. Conclusions: A conceptually grounded four-domain, function-neutral measure of HRQOL that is appropriate for use with persons with and without various functional limitations was developed. C1 [Krahn, Gloria L.; Horner-Johnson, Willi; Hall, Trevor A.; Drum, Charles E.; Suzuki, Rie; Peterson, Jana J.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Roid, Gale H.] Warner Pacific Coll, Portland, OR USA. [Andresen, Elena M.] Univ Florida, Gainesville, FL USA. [Fujiura, Glenn T.] Univ Illinois, Chicago, IL USA. [Nosek, Margaret A.] Baylor Coll Med, Houston, TX 77030 USA. [Cardinal, Bradley J.] Oregon State Univ, Corvallis, OR 97331 USA. RP Krahn, GL (reprint author), Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E88, Atlanta, GA 30333 USA. OI Horner-Johnson, Willi/0000-0003-3568-1400 FU United States Department of Education, National Institute on Disability and Rehabilitation Research (NIDRR) [H133B040034] FX Supported by funds from the United States Department of Education, National Institute on Disability and Rehabilitation Research (NIDRR), under grant number H133B040034, principal investigator Gloria Krahn, PhD, MPH, and project officer Phillip Beatty, PhD. NR 51 TC 2 Z9 2 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0894-9115 EI 1537-7385 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD JAN PY 2014 VL 93 IS 1 BP 56 EP 74 DI 10.1097/PHM.0b013e3182a517e6 PG 19 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AJ5OZ UT WOS:000337735800006 PM 24355997 ER PT J AU Le, D Holt, CL Pisu, M Brown-Galvan, A Fairley, TL Smith, JL White, A Hall, IJ Oster, RA Martin, MY AF Le, Daisy Holt, Cheryl L. Pisu, Maria Brown-Galvan, Aquila Fairley, Temeika L. Smith, Judith Lee White, Arica Hall, Ingrid J. Oster, Robert A. Martin, Michelle Y. TI The Role of Social Support in Posttreatment Surveillance Among African American Survivors of Colorectal Cancer SO JOURNAL OF PSYCHOSOCIAL ONCOLOGY LA English DT Article DE colorectal cancer; African American; guidelines; surveillance; colonoscopy; oncology ID QUALITY-OF-LIFE; RELIGIOUS INVOLVEMENT; BREAST-CANCER; RACIAL-DIFFERENCES; PHYSICAL HEALTH; FOLLOW-UP; CARE; SPIRITUALITY; GUIDELINE; RECEIPT AB African Americans are less likely than other groups to receive appropriate surveillance after colorectal cancer (CRC) treatment. The objective of this study is to qualitatively explore the role of social support in post-CRC treatment surveillance and ultimately, inform interventions to promote surveillance in African American survivors of CRC. Interviews were conducted with 60 African American survivors of CRC recruited from the Cancer Care Outcomes Research and Surveillance (CanCORS) study and the Alabama Statewide Cancer Registry. Interviews were recorded and transcribed. Transcripts were reviewed and coded independently by the authors. The NVivo software package was used to facilitate coding and data management. Survivors were from 4 to 6 years post diagnosis, 57% female, 60% older than age 65 years, 57% from rural Alabama, 30% with stage 1, 32% with stage 2, and 38% with stage 3 disease. Material and emotional social support from family and one's faith community were cited as playing an important role in coping with the disease and posttreatment surveillance. Survivors who reported being adherent with posttreatment surveillance recommendations (according to stage of disease based on self-report of colonoscopy, computed tomography scans, and blood work) reported more religious material and non-material social support, and support from other survivors of CRC. In these African American survivors of CRC, support from family, other survivors of cancer, and the faith community was perceived as being important for adherence to posttreatment surveillance. Interventions to increase posttreatment surveillance in this population may be enhanced by including components that emphasize familial, other cancer survivor, and religious support. C1 [Le, Daisy; Holt, Cheryl L.] Univ Maryland, Sch Publ Hlth, Dept Behav & Community Hlth, College Pk, MD 20742 USA. [Pisu, Maria; Brown-Galvan, Aquila; Oster, Robert A.; Martin, Michelle Y.] Univ Alabama Birmingham, Dept Med, Div Prevent Med, Birmingham, AL 35294 USA. [Pisu, Maria; Brown-Galvan, Aquila; Oster, Robert A.; Martin, Michelle Y.] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA. [Fairley, Temeika L.; Smith, Judith Lee; White, Arica; Hall, Ingrid J.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Holt, CL (reprint author), Univ Maryland, Sch Publ Hlth, Dept Behav & Community Hlth, 2369 Public Hlth Bldg 255, College Pk, MD 20742 USA. EM cholt14@umd.edu FU NCI NIH HHS [U01 CA93326, U01 CA93344, U01 CA93332, U01 CA93339, U01 CA93324, U01 CA93348, R01 CA105202]; PHS HHS [U36/CCU319276 CFDA 93.283] NR 57 TC 4 Z9 4 U1 2 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0734-7332 EI 1540-7586 J9 J PSYCHOSOC ONCOL JI J. Psychosoc. Oncol. PY 2014 VL 32 IS 3 BP 245 EP 263 DI 10.1080/07347332.2014.897293 PG 19 WC Psychology, Social SC Psychology GA AJ3MK UT WOS:000337570500001 PM 24611486 ER PT J AU Caruso, CC AF Caruso, Claire C. TI Negative Impacts of Shiftwork and Long Work Hours SO REHABILITATION NURSING LA English DT Article DE Shift work; occupational diseases; occupational injury; occupational exposure; work schedule tolerance; circadian rhythms; job stress; overtime work; extended work shifts; sleepiness ID SHORT-SLEEP DURATION; HEALTH-CARE SECTOR; SCHEDULE CHARACTERISTICS; PROSTATE-CANCER; MEDICAL ERRORS; HEART-DISEASE; UNITED-STATES; RISK-FACTORS; NIGHT WORK; NURSES AB Purpose: Healthcare organizations often have to provide patient care around the clock. Shift work (any shift outside of 7 a.m. to 6 p.m) and long work hours increase the risk for short sleep duration and sleep disturbances. Thirty-two percent of healthcare workers report they do not get enough sleep. The purpose of the article is to give an overview of the wide range of risks to nurses, patients, and employers that are linked to shift work, long work hours, and poor sleep from other sources. Findings: Shift work and long work hours increase the risk for reduced performance on the job, obesity, injuries, and a wide range of chronic diseases. In addition, fatigue-related errors could harm patients. Fatigued nurses also endanger others during their commute to and from work. Conclusion and Clinical Relevance: The key strategy to reduce these risks is making sleep a priority in the employer's systems for organizing work and in the nurse's personal life. C1 NIOSH, Cincinnati, OH 45226 USA. RP Caruso, CC (reprint author), NIOSH, 4676 Columbia Pkwy MS C-24, Cincinnati, OH 45226 USA. EM ZHL1@cdc.gov FU Intramural CDC HHS [CC999999] NR 78 TC 34 Z9 35 U1 8 U2 67 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0278-4807 EI 2048-7940 J9 REHABIL NURS JI Rehabil. Nurs. PD JAN-FEB PY 2014 VL 39 IS 1 BP 16 EP 25 DI 10.1002/rnj.107 PG 10 WC Nursing; Rehabilitation SC Nursing; Rehabilitation GA AJ2SP UT WOS:000337512500003 PM 23780784 ER PT J AU Hall, RM Earnest, GS Hammond, DR Dunn, KH Garcia, A AF Hall, Ronald M. Earnest, G. Scott Hammond, Duane R. Dunn, Kevin H. Garcia, Alberto TI A Summary of Research and Progress on Carbon Monoxide Exposure Control Solutions on Houseboats SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article AB Investigations of carbon monoxide (CO-related poisonings and deaths on houseboats were conducted by the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. These investigations measured hazardous CO concentrations on and around houseboats that utilize gasoline-powered generators. Engineering control devices were developed and tested to mitigate this deadly hazard. CO emissions were measured using various sampling techniques which included exhaust emission analyzers, detector tubes, evacuated containers (grab air samples analyzed by a gas chromatograph), and direct-reading CO monitors. CO results on houseboats equipped with gasoline-powered generators without emission controls indicated hazardous CO concentrations exceeding immediately dangerous to life and health (IDLH) levels in potentially occupied areas of the houseboat. Air sample results on houseboats that were equipped with engineering controls to remove the hazard were highly effective and reduced CO levels by over 98% in potentially occupied areas. The engineering control devices used to reduce the hazardous CO emissions from gasoline-powered generators on houseboats were extremely effective at reducing CO concentrations to safe levels in potentially occupied areas on the houseboats and are now beginning to be widely used. C1 [Hall, Ronald M.; Earnest, G. Scott; Hammond, Duane R.; Dunn, Kevin H.; Garcia, Alberto] NIOSH, Div Appl Res & Technol, Engn & Phys Hazards Branch, Cincinnati, OH 45226 USA. RP Hall, RM (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM rmhall@cdc.gov FU Intramural CDC HHS [CC999999] NR 31 TC 0 Z9 0 U1 1 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 7 BP D92 EP D100 DI 10.1080/15459624.2014.895374 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AI7SR UT WOS:000337099200002 PM 24568306 ER PT J AU Fasula, AM Carry, M Miller, KS AF Fasula, Amy M. Carry, Monique Miller, Kim S. TI A Multidimensional Framework for the Meanings of the Sexual Double Standard and its Application for the Sexual Health of Young Black Women in the US SO JOURNAL OF SEX RESEARCH LA English DT Article ID AFRICAN-AMERICAN WOMEN; RANDOMIZED CONTROLLED-TRIAL; HETEROSEXUAL COUPLES; ADOLESCENT GIRLS; CONDOM USE; PREVENTION INTERVENTION; GENDER IDEOLOGIES; DECISION-MAKING; HIV PREVENTION; BODY-IMAGE AB There has been debate in the literature as to whether a sexual double standard (SDS) currently exists in the United States. Studies vary greatly in how the SDS is operationalized, making it difficult to interpret findings across studies and translate academic literature into applied fields such as public health. To advance academic and applied research, we propose a multidimensional framework for the SDS that can accommodate complex and nuanced meanings, is flexible enough to allow for the dynamic nature of social ideologies, and is grounded in an understanding of social systems of inequality. In this article, we describe three dimensions that define the broad elements of the SDS: (a) polarized (hetero) sexualities, (b) active male and passive female roles, and (c) the power struggle narrative. To illustrate the use of the framework, we contextualize each dimension in terms of the intersection of race and gender for young Black women in the United States. And finally, to apply the framework, we explore the effects the SDS can have on sexual health and suggest some directions for public health interventions. These analyses lay the groundwork for more complex and comprehensive investigations of the SDS and its effects on sexual health. C1 [Fasula, Amy M.; Carry, Monique; Miller, Kim S.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Fasula, AM (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,Mail Stop E-37, Atlanta, GA 30333 USA. EM afasula@cdc.gov NR 110 TC 8 Z9 8 U1 4 U2 17 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0022-4499 EI 1559-8519 J9 J SEX RES JI J. Sex Res. PY 2014 VL 51 IS 2 BP 170 EP 183 DI 10.1080/00224499.2012.716874 PG 14 WC Psychology, Clinical; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA AI9CL UT WOS:000337225300005 PM 23148703 ER PT J AU Hoffmann, M Zhao, SH Pettengill, J Luo, Y Monday, SR Abbott, J Ayers, SL Cinar, HN Muruvanda, T Li, C Allard, MW Whichard, J Meng, JH Brown, EW McDermott, PF AF Hoffmann, Maria Zhao, Shaohua Pettengill, James Luo, Yan Monday, Steven R. Abbott, Jason Ayers, Sherry L. Cinar, Hediye N. Muruvanda, Tim Li, Cong Allard, Marc W. Whichard, Jean Meng, Jianghong Brown, Eric W. McDermott, Patrick F. TI Comparative Genomic Analysis and Virulence Differences in Closely Related Salmonella enterica Serotype Heidelberg Isolates from Humans, Retail Meats, and Animals SO GENOME BIOLOGY AND EVOLUTION LA English DT Article DE outbreak; antimicrobial resistance; plasmid; SNP analysis; trace-back ID IV SECRETION SYSTEMS; MULTILOCUS GENOTYPE DATA; SEROVAR HEIDELBERG; ESCHERICHIA-COLI; UNITED-STATES; POPULATION-STRUCTURE; CAENORHABDITIS-ELEGANS; PLASMID; DIVERSITY; EVOLUTION AB Salmonella enterica subsp. enterica serovar Heidelberg (S. Heidelberg) is one of the top serovars causing human salmonellosis. Recently, an antibiotic-resistant strain of this serovar was implicated in a large 2011 multistate outbreak resulting from consumption of contaminated ground turkey that involved 136 confirmed cases, with one death. In this study, we assessed the evolutionary diversity of 44 S. Heidelberg isolates using whole-genome sequencing (WGS) generated by the 454 GS FLX (Roche) platform. The isolates, including 30 with nearly indistinguishable (one band difference) Xbal pulsed-field gel electrophoresis patterns (JF6X01.0032, JF6X01.0058), were collected from various sources between 1982 and 2011 and included nine isolates associated with the 2011 outbreak. Additionally, we determined the complete sequence for the chromosome and three plasmids from a clinical isolate associated with the 2011 outbreak using the Pacific Biosciences (PacBio) system. Using single-nucleotide polymorphism (SNP) analyses, we were able to distinguish highly clonal isolates, including strains isolated at different times in the same year. The isolates from the recent 2011 outbreak clustered together with a mean SNP variation of only 17 SNPs. The S. Heidelberg isolates carried a variety of phages, such as prophage P22, P4, lambda-like prophage Gifsy-2, and the P2-like phage which carries the sopE1 gene, virulence genes including 62 pathogenicity, and 13 fimbrial markers and resistance plasmids of the incompatibility (Inc)I1, IncA/C, and IncHI2 groups. Twenty-one strains contained an IncX plasmid carrying a type IV secretion system. On the basis of the recent and historical isolates used in this study, our results demonstrated that, in addition to providing detailed genetic information for the isolates, WGS can identify SNP targets that can be utilized for differentiating highly clonal S. Heidelberg isolates. C1 [Hoffmann, Maria; Zhao, Shaohua; Abbott, Jason; Ayers, Sherry L.; Li, Cong; McDermott, Patrick F.] US FDA, Div Anim & Food Microbiol, Res Off, Ctr Vet Med, Laurel, MD 20708 USA. [Hoffmann, Maria; Meng, Jianghong] Univ Maryland, Inst Food Safety & Appl Nutr, College Pk, MD 20742 USA. [Pettengill, James; Luo, Yan] US FDA, Div Publ Hlth & Biostat, Off Food Def Commun & Emergency Response, Ctr Food Safety & Nutr, College Pk, MD USA. [Monday, Steven R.; Muruvanda, Tim; Allard, Marc W.; Brown, Eric W.] US FDA, Div Microbiol, Off Regulatory Sci, Ctr Food Safety & Nutr, College Pk, MD USA. [Cinar, Hediye N.] US FDA, Div Virulence Assessment, Off Appl Res & Safety Assessment, Ctr Food Safety & Nutr, Laurel, MD USA. [Whichard, Jean] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Hoffmann, M (reprint author), US FDA, Div Anim & Food Microbiol, Res Off, Ctr Vet Med, Laurel, MD 20708 USA. EM maria.hoffman@fda.hhs.gov; Patrick.McDermott@fda.hhs.gov FU Center for Veterinary Medicine; Center for Food Safety and Applied Nutrition at the US Food and Drug Administration; Joint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, MD FX The authors thank Ruth Timme for submission of the draft genomes to NCBI and the NCBI rapid annotation pipeline team, Bill Klimke, Dmitry Dernovoy, Stacy Ciufo, Kathleen O'Neill, Azat Badretdin, and Tatiana Tatusova, for key genome annotation service. Further they thank Yuansha Chen for sharing the CVM/DAFM database of antimicrobial resistance genes. No human subjects or animals were used in this study. All authors have read the manuscript and agreed to its contents, subject matter, and author line order. These data are novel and have not been previously published elsewhere. Disclosure forms provided by the authors will be available with the full text of this article. This work was supported by the Center for Veterinary Medicine and the Center for Food Safety and Applied Nutrition at the US Food and Drug Administration and by an appointment of MH by the Joint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, MD. NR 64 TC 22 Z9 22 U1 0 U2 28 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1759-6653 J9 GENOME BIOL EVOL JI Genome Biol. Evol. PY 2014 VL 6 IS 5 BP 1046 EP 1068 DI 10.1093/gbe/evu079 PG 23 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA AI7BY UT WOS:000337037100002 PM 24732280 ER PT J AU de Perio, MA Niemeier, RT AF de Perio, Marie A. Niemeier, R. Todd TI Evaluation of Exposure to Tuberculosis Among Employees at a Medical Center SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID HEALTH-CARE WORKERS; NOSOCOMIAL TRANSMISSION; MYCOBACTERIUM-TUBERCULOSIS; UNSUSPECTED DISEASE; RISK; INFECTION; OUTBREAK C1 [de Perio, Marie A.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Niemeier, R. Todd] NIOSH, Educ & Informat Div, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP de Perio, MA (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,R-10, Cincinnati, OH 45226 USA. EM mdeperio@cdc.gov FU Intramural CDC HHS [CC999999] NR 18 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2014 VL 11 IS 6 BP D63 EP D68 DI 10.1080/15459624.2014.888075 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AI7SO UT WOS:000337098800001 PM 24499024 ER PT J AU Keck, JW Redd, JT Cheek, JE Layne, LJ Groom, AV Kitka, S Bruce, MG Suryaprasad, A Amerson, NL Cullen, T Bryan, RT Hennessy, TW AF Keck, James W. Redd, John T. Cheek, James E. Layne, Larry J. Groom, Amy V. Kitka, Sassa Bruce, Michael G. Suryaprasad, Anil Amerson, Nancy L. Cullen, Theresa Bryan, Ralph T. Hennessy, Thomas W. TI Influenza surveillance using electronic health records in the American Indian and Alaska Native population SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article ID A H1N1; ILLNESS; RISK AB Objective Increasing use of electronic health records (EHRs) provides new opportunities for public health surveillance. During the 2009 influenza A (H1N1) virus pandemic, we developed a new EHR-based influenza-like illness (ILI) surveillance system designed to be resource sparing, rapidly scalable, and flexible. 4 weeks after the first pandemic case, ILI data from Indian Health Service (IHS) facilities were being analyzed. Materials and methods The system defines ILI as a patient visit containing either an influenza-specific International Classification of Disease, V. 9 (ICD-9) code or one or more of 24 ILI-related ICD-9 codes plus a documented temperature >= 100 degrees F. EHR-based data are uploaded nightly. To validate results, ILI visits identified by the new system were compared to ILI visits found by medical record review, and the new system's results were compared with those of the traditional US ILI Surveillance Network. Results The system monitored ILI activity at an average of 60% of the 269 IHS electronic health databases. EHR-based surveillance detected ILI visits with a sensitivity of 96.4% and a specificity of 97.8% based on chart review (N=2375) of visits at two facilities in September 2009. At the peak of the pandemic (week 41, October 17, 2009), the median time from an ILI visit to data transmission was 6 days, with a mode of 1 day. Discussion EHR-based ILI surveillance was accurate, timely, occurred at the majority of IHS facilities nationwide, and provided useful information for decision makers. EHRs thus offer the opportunity to transform public health surveillance. C1 [Keck, James W.; Groom, Amy V.; Kitka, Sassa; Bruce, Michael G.; Suryaprasad, Anil; Amerson, Nancy L.; Bryan, Ralph T.; Hennessy, Thomas W.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Redd, John T.; Cheek, James E.; Layne, Larry J.; Cullen, Theresa] Indian Hlth Serv, Albuquerque, NM USA. RP Redd, JT (reprint author), Santa Fe Indian Hosp, 1700 Cerrillos Rd, Santa Fe, NM 87508 USA. EM john.redd@ihs.gov NR 13 TC 3 Z9 3 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1067-5027 EI 1527-974X J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD JAN PY 2014 VL 21 IS 1 BP 132 EP 138 DI 10.1136/amiajnl-2012-001591 PG 7 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics SC Computer Science; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics GA AI2VK UT WOS:000336716000020 PM 23744788 ER PT J AU Creanga, AA Berg, CJ Ko, JY Farr, SL Tong, VT Bruce, FC Callaghan, WM AF Creanga, Andreea A. Berg, Cynthia J. Ko, Jean Y. Farr, Sherry L. Tong, Van T. Bruce, F. Carol Callaghan, William M. TI Maternal Mortality and Morbidity in the United States: Where Are We Now? SO JOURNAL OF WOMENS HEALTH LA English DT Article ID PREGNANCY-RELATED MORTALITY; PREPREGNANCY OBESITY TRENDS; REPRODUCTIVE AGE; WOMEN; HEALTH; DEPRESSION; INFLUENZA; DELIVERY; HOSPITALIZATIONS; ASSOCIATION AB This article provides a brief overview of the work conducted by the Division of Reproductive Health at the Centers for Disease Control and Prevention on severe maternal morbidity and mortality in the United States. The article presents the latest data and trends in maternal mortality and severe maternal morbidity, as well as on maternal substance abuse and mental health disorders during pregnancy, two relatively recent topics of interest in the Division, and includes future directions of work in all these areas. C1 [Creanga, Andreea A.; Berg, Cynthia J.; Ko, Jean Y.; Farr, Sherry L.; Tong, Van T.; Bruce, F. Carol; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Creanga, AA (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, 4770 Buford Highway Northeast,Mail Stop K-23, Atlanta, GA 30341 USA. EM acreanga@cdc.gov OI Tong, Van/0000-0002-3970-1440 FU Intramural CDC HHS [CC999999] NR 47 TC 51 Z9 51 U1 1 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JAN PY 2014 VL 23 IS 1 BP 3 EP 9 DI 10.1089/jwh.2013.4617 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AI4BZ UT WOS:000336811900002 PM 24383493 ER PT J AU Olsen, SJ Kittikraisak, W Fernandez, S Suntarattiwong, P Chotpitayasunondh, T AF Olsen, Sonja J. Kittikraisak, Wanitchaya Fernandez, Stefan Suntarattiwong, Piyarat Chotpitayasunondh, Tawee TI Challenges With New Rapid Influenza Diagnostic Tests SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Letter C1 [Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Olsen, Sonja J.; Kittikraisak, Wanitchaya] Thailand MOPH US CDC Collaborat, Influenza Program, Nonthaburi, Thailand. [Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Olsen, SJ (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 6 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2014 VL 33 IS 1 BP 117 EP 118 DI 10.1097/INF.0000000000000089 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AH9ZP UT WOS:000336505700037 PM 24346605 ER PT J AU Ortiz, AP Unger, ER Munoz, C Panicker, G Tortolero-Luna, G Soto-Salgado, M Otero, Y Suarez, E Perez, CM AF Ortiz, A. P. Unger, E. R. Munoz, C. Panicker, G. Tortolero-Luna, G. Soto-Salgado, M. Otero, Y. Suarez, E. Perez, C. M. TI Cross-sectional study of HPV-16 infection in a population-based subsample of Hispanic adults SO BMJ OPEN LA English DT Article DE EPIDEMIOLOGY ID PAPILLOMAVIRUS TYPE-16 INFECTION; UNITED-STATES; ANTIBODY-RESPONSE; SEROPREVALENCE; WOMEN; MEN; SEROEPIDEMIOLOGY; PREVALENCE; RISK; DNA AB Objective This study aimed to estimate the prevalence and correlates of seropositivity to human papillomavirus (HPV)-16 in a subsample of adults who participated in the parent study Epidemiology of Hepatitis C in the adult population of Puerto Rico (PR). Setting The parent study was a population-based household survey aimed to estimate the seroprevalence of hepatitis C and other viral infections (hepatitis A, hepatitis B, HIV, and herpes simplex type 2) in PR (n=1654) between 2005 and 2008. Participants A subsample of the last 450 consecutive adults aged 21-64years, recruited between February 2007 and January 2008, who participated in the parent study and agreed to participate in HPV testing. Primary and secondary outcome measures The samples were tested by ELISA for HPV-16 viral-like particle-specific immunoglobulin G. Information on sociodemographic, health, and lifestyle characteristics was collected. Logistic regression modelling was used to estimate the prevalence odds ratio (POR) to assess factors associated to HPV-16 seropositivity. Results Prevalence of seropositivity to HPV-16 was 11.3%. Seroprevalence was higher in women (15.8%) than men (5.6%; p=0.001). After adjusting for age and sex, ever smokers (POR 2.06, 95% CI 1.08 to 3.92) and participants with at least five lifetime sexual partners (POR 2.91, 95% CI 1.24 to 6.81) were more likely to be HPV-16 seropositive. Conclusions HPV-16 seropositivity is similar to that reported in the USA (10.4%) for NHANES 2003-2004 participants, although different assays were used in these studies. While future studies should evaluate HPV seroprevalence using a larger population-based sample, our results highlight the need to further understand the burden of HPV infection and HPV-related malignancies in PR, population with a low vaccine uptake. C1 [Ortiz, A. P.; Tortolero-Luna, G.] Univ Puerto Rico, Ctr Comprehens Canc, Canc Control & Populat Sci Program, San Juan, PR 00936 USA. [Ortiz, A. P.; Munoz, C.; Suarez, E.; Perez, C. M.] Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, San Juan, PR 00936 USA. [Unger, E. R.; Panicker, G.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Atlanta, GA USA. [Soto-Salgado, M.; Otero, Y.] Univ Puerto Rico, Sch Med, UPR MDACC Partnership Excellence Canc Res, San Juan, PR 00936 USA. RP Ortiz, AP (reprint author), Univ Puerto Rico, Ctr Comprehens Canc, Canc Control & Populat Sci Program, San Juan, PR 00936 USA. EM ana.ortiz7@upr.edu FU NIH NIGMS MBRS-SCORE Programme [S06-GM08224]; NICHD/EARDA [1G11HD046326]; MBRS-SCORE, National Institute of Allergy and Infectious Diseases, National Institutes of Health [1 SC2 AI090922-01]; NIH/NCRR/RCMI/UPR [G12RR03051]; NCRR [U54-RR 026139-01A1]; NIMHD from Training in Computational Genomic Epidemiology of Cancer, National Institute of Cancer [8U54-MD 007587-03 5R25CA094186-07]; U54 Partnership for Excellence in Cancer Research, National Cancer Institute [U54CA96297, U54CA96300] FX The project described was fully supported by S06-GM08224 from NIH NIGMS MBRS-SCORE Programme, 1G11HD046326 from NICHD/EARDA and 1 SC2 AI090922-01 from MBRS-SCORE, National Institute of Allergy and Infectious Diseases, National Institutes of Health. This study was partially supported by G12RR03051 from NIH/NCRR/RCMI/UPR, NCRR Award Number U54-RR 026139-01A1 & NIMHD Award Number 8U54-MD 007587-03 5R25CA094186-07 from Training in Computational Genomic Epidemiology of Cancer, National Institute of Cancer and by U54CA96297, U54CA96300 from U54 Partnership for Excellence in Cancer Research, National Cancer Institute. The Centers for Disease Control and Prevention provided support for HPV testing. NR 25 TC 2 Z9 2 U1 0 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-6055 J9 BMJ OPEN JI BMJ Open PY 2014 VL 4 IS 2 AR e004203 DI 10.1136/bmjopen-2013-004203 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AF1FF UT WOS:000334459100081 PM 24496698 ER PT J AU Grzywacz, JG Alterman, T Gabbard, S Shen, R Nakamoto, J Carroll, DJ Muntaner, C AF Grzywacz, Joseph G. Alterman, Toni Gabbard, Susan Shen, Rui Nakamoto, Jorge Carroll, Daniel J. Muntaner, Carles TI Job Control, Psychological Demand, and Farmworker Health Evidence From the National Agricultural Workers Survey SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID HIRED FARM-WORKERS; LATINO FARMWORKERS; MIGRANT FARMWORKERS; NORTH-CAROLINA; MENTAL-HEALTH; SEASONAL FARMWORKERS; DEPRESSIVE SYMPTOMS; PESTICIDE EXPOSURE; CARE UTILIZATION; UNITED-STATES AB Objective: Improve understanding of the potential occupational health impact of how agricultural jobs are organized. Exposure to low job control, high psychological demands, and high job strain were hypothesized to have greater risk for poor self-rated physical health and elevated depressive symptoms. Methods: Cross-sectional data (N = 3691) obtained using the Work Organization and Psychosocial Factors module of the US National Agricultural Workers Survey fielded in 2009-2010. Results: More than one fifth (22.4%) of farmworkers reported fair/poor health, and 8.7% reported elevated depressive symptoms. High psychological demand was associated with increased risk of fair/poor health (odds ratio, 1.73; 95% confidence interval, 1.4 to 2.2) and elevated depressive symptoms (odds ratio, 2.6; 95% confidence interval, 1.9 to 3.8). Conclusions: The organization of work in field agriculture may pose risks for poor occupational health outcomes among a vulnerable worker population. C1 [Grzywacz, Joseph G.] Oklahoma State Univ, Dept Human Dev & Family Sci, Tulsa, OK 74106 USA. [Grzywacz, Joseph G.] Oklahoma State Univ, Ctr Family Resilience, Tulsa, OK 74106 USA. [Alterman, Toni] NIOSH, Div Surveillance Hazard Evaluat & Field Studi, Cincinnati, OH 45226 USA. [Gabbard, Susan; Nakamoto, Jorge] JBS Int, Aguirre Div, Burlingame, CA USA. [Shen, Rui] Emergint Technol, Cincinnati, OH USA. [Carroll, Daniel J.] US Dept Labor, Employment & Training Adm, Washington, DC 20210 USA. [Muntaner, Carles] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Muntaner, Carles] Univ Toronto, Bloomberg Fac Nursing, Toronto, ON, Canada. RP Grzywacz, JG (reprint author), Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave,Main Hall 2120, Tulsa, OK 74106 USA. EM joseph.grzywacz@okstate.edu OI Alterman, Toni/0000-0003-1512-4367 NR 38 TC 6 Z9 6 U1 1 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2014 VL 56 IS 1 BP 66 EP 71 DI 10.1097/JOM.0000000000000025 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH6MY UT WOS:000336246200009 PM 24351891 ER PT J AU Beitsch, LM Corso, LC Davis, MV Joly, BM Kronstadt, J Riley, WJ AF Beitsch, Leslie M. Corso, Liza C. Davis, Mary V. Joly, Brenda M. Kronstadt, Jessica Riley, William J. TI Transforming Public Health Practice Through Accreditation (A User Guide for the Special Accreditation Issue) SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material ID STATES C1 [Beitsch, Leslie M.] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA. [Corso, Liza C.] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Atlanta, GA USA. [Davis, Mary V.] Univ N Carolina, North Carolina Inst Publ Hlth, Chapel Hill Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA. [Joly, Brenda M.] Univ So Maine, Grad Program Publ Hlth, Portland, ME 04103 USA. [Kronstadt, Jessica] Publ Hlth Accreditat Board, Alexandria, VA USA. [Riley, William J.] Arizona State Univ, Sch Sci Hlth Care Delivery, Coll Hlth Solut, Phoenix, AZ USA. RP Beitsch, LM (reprint author), Florida State Univ, Coll Med, 1115 West Call St, Tallahassee, FL 32306 USA. EM les.beitsch@med.fsu.edu NR 9 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 2 EP 3 DI 10.1097/PHH.0b013e3182a8ea1e PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300002 PM 24322676 ER PT J AU Monteiro, E Fisher, JS Daub, T Zamperetti, MC AF Monteiro, Erinn Fisher, Jessica Solomon Daub, Teresa Zamperetti, Michelle Chuk TI CDC/NACCHO Accreditation Support Initiative: Advancing Readiness for Local and Tribal Health Department Accreditation SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE funding; tribal health departments; local health departments; accreditation AB Context: Health departments have various unique needs that must be addressed in preparing for national accreditation. These needs require time and resources, shortages that many health departments face. Objective: The Accreditation Support Initiative's goal was to test the assumption that even small amounts of dedicated funding can help health departments make important progress in their readiness to apply for and achieve accreditation. Design: Participating sites' scopes of work were unique to the needs of each site and based on the proposed activities outlined in their applications. Deliverables and various sources of data were collected from sites throughout the project period (December 2011-May 2012). Setting/Participants: Awardees included 1 tribal and 12 local health departments, as well as 5 organizations supporting the readiness of local and tribal health departments. Results: Sites dedicated their funding toward staff time, accreditation fees, completion of documentation, and other accreditation readiness needs and produced a number of deliverables and example documents. All sites indicated that they made accreditation readiness gains that would not have occurred without this funding. Conclusions: Preliminary evaluation data from the first year of the Accreditation Support Initiative indicate that flexible funding arrangements may be an effective way to increase health departments' accreditation readiness. C1 [Monteiro, Erinn; Fisher, Jessica Solomon; Zamperetti, Michelle Chuk] Natl Assoc Cty & City Hlth Officials, Washington, DC 20036 USA. [Daub, Teresa] Ctr Dis Control & Prevent, Dept Hlth, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA USA. Ctr Dis Control & Prevent, Syst Dev Branch, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA USA. RP Monteiro, E (reprint author), Natl Assoc Cty & City Hlth Officials, 1100 17th St NW,Ste 700, Washington, DC 20036 USA. EM emonteiro@naccho.org FU NCHM CDC HHS [HM08-805] NR 8 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 14 EP 19 DI 10.1097/PHH.0b013e3182a336f3 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300006 PM 24322680 ER PT J AU Marshall, D Pyron, T Jimenez, J Coffman, J Pearsol, J Koester, D AF Marshall, Donna Pyron, Trina Jimenez, Jennifer Coffman, Joya Pearsol, Jim Koester, Deb TI Improving Public Health Through State Health Improvement Planning: A Framework for Action SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE SHIP Guidance and Resources; health improvement planning; state health improvement planning; national accreditation ID COMMUNITY-HEALTH AB Background: State health improvement plans (SHIPs) identify priorities for making the greatest impacts on health promotion and disease prevention, specific to the needs of state populations. Both SHIPs and the state health assessments on which they are based are prerequisites for Public Health Accreditation Board national accreditation. Objective: To identify and evaluate existing SHIPs to develop guidance to support health departments in the state health improvement planning process. Design: In 2010, the Association of State and Territorial Health Officials (ASTHO) conducted a comprehensive search for existing SHIPs. A systematic evaluation of existing SHIPS was accomplished by means of primary source document review using a standardized data collection form. Using data derived from these SHIPs and guidance from a workgroup of practitioners, ASTHO developed the ASTHO SHIP Guidance and Resources (SHIP Guidance) Framework. Results: The search yielded 25 states (49%) having a SHIP completed or in progress. Fifteen states (29%) had no SHIP but had a Healthy People plan, and 10 states (20%) had no SHIP or Healthy People plan. No information was available for 1 state. Findings were reviewed, evaluated, and incorporated into the SHIP Guidance. The SHIP Guidance provides a framework for the implementation, monitoring, and evaluation of a SHIP process using 12 key steps. Conclusions: As public health/health care integration and accreditation readiness activity grows, multisector engagement through a SHIP will continue to be a priority for state public health and improving health outcomes. The SHIP Guidance provides a systematic, flexible approach for states conducting or updating state health assessments and SHIPs. C1 [Marshall, Donna; Coffman, Joya] Assoc State & Terr Hlth Officials, Arlington, VA 22202 USA. [Pearsol, Jim] Assoc State & Terr Hlth Officials, Publ Hlth Performance Team, Arlington, VA 22202 USA. [Pyron, Trina] Ctr Dis Control & Prevent, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA USA. [Koester, Deb] Ctr Dis Control & Prevent, Carter Consulting Inc, Off State Tribal Local & Terr Support, Atlanta, GA USA. [Jimenez, Jennifer] Publ Hlth Accreditat Board, Alexandria, VA USA. RP Marshall, D (reprint author), Assoc State & Terr Hlth Officials, 2231 Crystal Dr,Ste 450, Arlington, VA 22202 USA. EM dmarshall@astho.org NR 10 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 23 EP 28 DI 10.1097/PHH.0b013e3182a5a4b8 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300008 PM 24322682 ER PT J AU McLees, AW Thomas, CW Nawaz, S Young, AC Rider, N Davis, M AF McLees, Anita W. Thomas, Craig W. Nawaz, Saira Young, Andrea C. Rider, Nikki Davis, Mary TI Advances in Public Health Accreditation Readiness and Quality Improvement: Evaluation Findings From the National Public Health Improvement Initiative SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE performance management; performance standards; public health accreditation; evaluation; quality improvement ID DEPARTMENTS; SYSTEMS AB Introduction: Continuous quality improvement is a central tenet of the Public Health Accreditation Board's (PHAB) national voluntary public health accreditation program. Similarly, the Centers for Disease Control and Prevention launched the National Public Health Improvement Initiative (NPHII) in 2010 with the goal of advancing accreditation readiness, performance management, and quality improvement (QI). Objective: Evaluate the extent to which NPHII awardees have achieved program goals. Design: NPHII awardees responded to an annual assessment and program monitoring data requests. Analysis included simple descriptive statistics. Setting: Seventy-four state, tribal, local, and territorial public health agencies receiving NPHII funds. Participants: NPHII performance improvement managers or principal investigators. Main Outcome Measure(s): Development of accreditation prerequisites, completion of an organizational self-assessment against the PHAB Standards and Measures, Version 1.0, establishment of a performance management system, and implementation of QI initiatives to increase efficiency and effectiveness. Results: Of the 73 responding NPHII awardees, 42.5% had a current health assessment, 26% had a current health improvement plan, and 48% had a current strategic plan in place at the end of the second program year. Approximately 26% of awardees had completed an organizational PHAB self-assessment, 72% had established at least 1 of the 4 components of a performance management system, and 90% had conducted QI activities focused on increasing efficiencies and/or effectiveness. Conclusions: NPHII appears to be supporting awardees' initial achievement of program outcomes. As NPHII enters its third year, there will be additional opportunities to advance the work of NPHII, compile and disseminate results, and inform a vision of high-quality public health necessary to improve the health of the population. C1 [McLees, Anita W.; Thomas, Craig W.; Nawaz, Saira; Young, Andrea C.] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, US Dept HHS, Atlanta, GA 30345 USA. [Rider, Nikki] Natl Network Publ Hlth Inst, New Orleans, LA USA. [Davis, Mary] Univ N Carolina, North Carolina Inst Publ Hlth, UNC Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. RP McLees, AW (reprint author), Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, 1825 Century Ctr MS E-70, Atlanta, GA 30345 USA. EM zdu5@cdc.gov FU Intramural CDC HHS [CC999999] NR 18 TC 11 Z9 11 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 29 EP 35 DI 10.1097/PHH.0b013e31829ff726 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300009 PM 24322683 ER PT J AU Thomas, CW Pietz, H Corso, L Erlwein, B Monroe, J AF Thomas, Craig W. Pietz, Harald Corso, Liza Erlwein, Bobbie Monroe, Judith TI Advancing Accreditation Through the National Public Health Improvement Initiative SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article C1 [Pietz, Harald] Ctr Dis Control & Prevent, Dept Hlth, Atlanta, GA 30329 USA. [Pietz, Harald] Ctr Dis Control & Prevent, Syst Dev Branch, Atlanta, GA 30329 USA. [Thomas, Craig W.; Corso, Liza; Erlwein, Bobbie] Ctr Dis Control & Prevent, Div Publ Hlth Performance Improvement, Atlanta, GA 30329 USA. [Monroe, Judith] Ctr Dis Control & Prevent, Off State Tribal Local & Terr, Atlanta, GA 30329 USA. RP Thomas, CW (reprint author), Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Century Ctr 1825, MS E70, Atlanta, GA 30329 USA. EM CHT2@cdc.gov NR 10 TC 5 Z9 5 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 36 EP 38 DI 10.1097/PHH.0b013e3182a8a5cb PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300010 PM 24322684 ER PT J AU Wallace, H Tilson, H Carlson, VP Valasek, T AF Wallace, Harvey Tilson, Hugh Carlson, Valeria P. Valasek, Tricia TI Instrumental Roles of Governance in Accreditation: Responsibilities of Public Health Governing Entities SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article C1 [Wallace, Harvey] No Michigan Univ, Coll Profess Studies, Marquette, MI 49855 USA. [Tilson, Hugh] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Carlson, Valeria P.] Ctr Dis Control & Prevent, Hlth Dept Syst Dev Branch, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA USA. [Valasek, Tricia] Univ Findlay, Findlay, OH USA. [Valasek, Tricia] Natl Assoc Local Boards Hlth, Bowling Green, OH USA. RP Wallace, H (reprint author), No Michigan Univ, Coll Profess Studies, Marquette, MI 49855 USA. EM hwallace@nmu.edu FU Intramural CDC HHS [CC999999] NR 6 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 61 EP 63 DI 10.1097/PHH.0b013e3182a45141 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300016 PM 24322689 ER PT J AU Thielen, L Leff, M Corso, L Monteiro, E Fisher, JS Pearsol, J AF Thielen, Lee Leff, Marilyn Corso, Liza Monteiro, Erinn Fisher, Jessica Solomon Pearsol, Jim TI A Study of Incentives to Support and Promote Public Health Accreditation SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE public health accreditation; incentives AB Context: Accreditation of public health agencies through the Public Health Accreditation Board is voluntary. Incentives that encourage agencies to apply for accreditation have been suggested as important factors in facilitating participation by state and local agencies. Objective: The project describes both current and potential incentives that are available at the federal, state, and local levels. Design: Thirty-nine key informants from local, state, tribal, federal, and academic settings were interviewed from March through May 2012. Through open-ended interviews, respondents were asked about incentives that were currently in use in their settings and incentives they thought would help encourage participation in Public Health Accreditation Board accreditation. Results: Incentives currently in use by public health agencies based on interviews include (1) financial support, (2) legal mandates, (3) technical assistance, (4) peer support workgroups, and (5) state agencies serving as role models by seeking accreditation themselves. Key informants noted that state agencies are playing valuable and diverse roles in providing incentives for accreditation within their own states. Key informants also identified the Centers for Disease Control and Prevention and other players, such as private foundations, public health institutes, national and state associations, and academia as providing both technical and financial assistance to support accreditation efforts. Conclusions: State, tribal, local, and federal agencies, as well as related organizations can play an important role by providing incentives to move agencies toward accreditation. C1 [Thielen, Lee; Leff, Marilyn] Thielen Consulting, Ft Collins, CO 80524 USA. [Corso, Liza] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Div Publ Hlth Performance Improvement, Atlanta, GA USA. [Monteiro, Erinn; Fisher, Jessica Solomon] Natl Assoc Cty & City Hlth Officials, Washington, DC USA. [Pearsol, Jim] Assoc State & Terr Hlth Officials, Arlington, VA USA. RP Thielen, L (reprint author), Thielen Consulting, 1308 Lindenwood Dr, Ft Collins, CO 80524 USA. EM leethielen@aol.com NR 11 TC 6 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 98 EP 103 DI 10.1097/PHH.0b013e31829ed746 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300029 PM 24322702 ER PT J AU Mercer, SL Banks, SM Verma, P Fisher, JS Corso, LC Carlson, V AF Mercer, Shawna L. Banks, Starr M. Verma, Pooja Fisher, Jessica Solomon Corso, Liza C. Carlson, Valeria TI Guiding the Way to Public Health Improvement: Exploring the Connections Between The Community Guide's Evidence-Based Interventions and Health Department Accreditation Standards SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE quality improvement; performance management; public health improvement; public health systems; public health accreditation; evidence-based public health AB Context: Recent years have seen rising interest in initiatives that focus on public health improvement. This includes support for accreditation of public health departments-administered by the Public Health Accreditation Board (PHAB)-and increasing expectations that health departments should use evidence-based programs, services, and policies (interventions) such as those described in The Guide to Community Preventive Services (The Community Guide). Objective: This project was initiated to explore the potential connections between Community Guide interventions and PHAB domains, standards, and measures. Design: The project team focused on developing a Crosswalk tool to assist health departments in identifying evidence-based interventions from The Community Guide whose implementation could help document conformity with PHAB domains, standards, and measures. All Community Preventive Services Task Force-recommended interventions were reviewed to determine whether they reflect the intent and requirements of the PHAB standards and measures. Main Outcome Measures: Three types of connections were defined through which Community Guide interventions could be relevant to the required documentation for a PHAB measure. All instances of these connections were identified and included in the Crosswalk. Results: The Crosswalk tool consists of 2 tables. The first table cross-references individual PHAB domains, standards, and measures with interventions from The Community Guide that could help provide documentation for accreditation. The second table can help accreditation preparation staff to engage with program staff. It is searchable by Community Guide topic, identifying the PHAB measures that relate to each Community Guide intervention within that topic. The type, location, and extent of connections between Community Guide interventions and PHAB domains, standards, and measures are presented and discussed. Conclusions: Tools such as the Crosswalk can be instrumental in advancing the use of evidence-based interventions in public health practice. C1 [Mercer, Shawna L.; Banks, Starr M.] Ctr Dis Control & Prevent, Community Guide Branch, Div Epidemiol Anal & Lib Serv Proposed, Ctr Surveillance Epidemiol & Lab Serv Proposed,Of, Atlanta, GA 30329 USA. [Corso, Liza C.; Carlson, Valeria] Ctr Dis Control & Prevent, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA 30329 USA. [Verma, Pooja] Natl Assoc Cty & City Hlth Officials, Accreditat & Qual Improvement, Washington, DC USA. [Fisher, Jessica Solomon] Natl Assoc Cty & City Hlth Officials, Publ Hlth Programs, Washington, DC USA. RP Mercer, SL (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mail Stop E-69, Atlanta, GA 30329 USA. EM SMercer@cdc.gov FU NCHM CDC HHS [HM08-805301SUPP10] NR 12 TC 3 Z9 3 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 104 EP 110 DI 10.1097/PHH.0b013e3182aa444c PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300030 PM 24322703 ER PT J AU Singleton, CM Corso, L Koester, D Carlson, V Bevc, CA Davis, MV AF Singleton, Christa-Marie Corso, Liza Koester, Deborah Carlson, Valeria Bevc, Christine A. Davis, Mary V. TI Accreditation and Emergency Preparedness: Linkages and Opportunities for Leveraging the Connections SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE public health emergency preparedness; accreditation; public health AB Background: Public health officials must frequently demonstrate the quality and value of public health services, especially during challenging fiscal climates. One of the ways that public health quality and accountability have been demonstrated is through the use of accreditation and standard setting initiatives. Objective: The objective of this analysis was to identify existing alignment opportunities between standards established by the Public Health Accreditation Board (PHAB) and the Centers for Disease Control and Prevention's (CDC's) public health preparedness (PHP) capabilities in order to optimize and leverage the connections for state and local public health professionals. Design: During March-May 2012, a PHAB/PHP crosswalk was developed by a research team from the CDC's Office for State, Tribal, Local and Territorial Support and Office of Public Health Preparedness and Response's Division of State and Local Readiness to examine the intersection of the PHP capabilities and the PHAB standards. The PHAB/PHP crosswalk used the CDC Public Health Preparedness Capabilities: National Standards for State and Local Planning (PHP Capabilities) and the PHAB Standards and Measures, Version 1.0 (PHAB Standards) as its source documents. To help illustrate the results of the crosswalk, alignment was also depicted through a network graph to transform the results into a visual depiction of the linkages between PHP capabilities and PHAB standards. Results: The most direct links to emergency preparedness were found in PHAB Domains 2 and 5. Opportunities for improved alignment were found throughout the standard documents, particularly in PHAB Domains 3, 8, and 11. The most direct links to accreditation were found in PHP capabilities 1, 2, 3, and 4. Conclusions: The results highlight the synergy between the infrastructure and foundational elements represented by accreditation and targeted programmatic activities supported by preparedness funding. C1 [Singleton, Christa-Marie] Ctr Dis Control & Prevent, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Corso, Liza] Ctr Dis Control & Prevent, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Koester, Deborah] Carter Consulting Inc, Atlanta, GA USA. [Koester, Deborah] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Carlson, Valeria] Ctr Dis Control & Prevent, Dept Hlth, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Carlson, Valeria] Ctr Dis Control & Prevent, Syst Dev Branch, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Bevc, Christine A.; Davis, Mary V.] UNC Gillings Sch Global Publ Hlth, North Carolina Inst Publ Hlth, Chapel Hill, NC USA. RP Singleton, CM (reprint author), Ctr Dis Control & Prevent, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, 600 Clifton Rd, Atlanta, GA 30333 USA. EM zbi9@cdc.gov FU OPHPR CDC HHS [1P01TP000296] NR 18 TC 4 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 119 EP 124 DI 10.1097/PHH.0b013e3182a9dbd8 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300032 PM 24322705 ER PT J AU Koo, D Miner, KR Tilson, HH Halverson, PK AF Koo, Denise Miner, Kathleen R. Tilson, Hugh H. Halverson, Paul K. TI Workforce Standards as Part of Health Department Accreditation-Necessary but Not Yet Sufficient SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article C1 [Koo, Denise] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Miner, Kathleen R.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Tilson, Hugh H.] UNC Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Halverson, Paul K.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA. RP Koo, D (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E-92, Atlanta, GA 30333 USA. EM dkoo@cdc.gov NR 5 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 125 EP 127 DI 10.1097/PHH.0b013e3182a5a3a7 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300033 PM 24322706 ER PT J AU Daub, T Doshi, S Elligers, JJ Pavletic, D Pyron, T AF Daub, Teresa Doshi, Sonal Elligers, Julia Joh Pavletic, Denise Pyron, Trina TI Leveraging the Revised National Public Health Performance Standards toMeet Today's Ever-Changing Public Health System Landscape SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 [Daub, Teresa; Doshi, Sonal; Pyron, Trina] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Div Publ Hlth Performance Improvement, Atlanta, GA 30341 USA. [Elligers, Julia Joh] Natl Assoc Cty & City Hlth Officials, Washington, DC USA. [Pavletic, Denise] Assoc State & Terr Hlth Officials, Arlington, VA USA. RP Daub, T (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS E-70, Atlanta, GA 30341 USA. EM tdaub@cdc.gov NR 10 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 135 EP 137 DI 10.1097/PHH.0b013e3182a7bdae PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300035 PM 24322708 ER PT J AU Monroe, J Collins, J Ikeda, R Khabbaz, R AF Monroe, Judith Collins, Janet Ikeda, Robin Khabbaz, Rima TI Institutionalizing Public Health Department Accreditation Through CDC Opportunities SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material ID PERFORMANCE C1 [Monroe, Judith] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Atlanta, GA 30341 USA. [Collins, Janet] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. [Ikeda, Robin] Ctr Dis Control & Prevent, Off Noncommunicable Dis Injury & Environm Hlth, Atlanta, GA 30341 USA. [Khabbaz, Rima] Ctr Dis Control & Prevent, Off Infect Dis, Atlanta, GA 30341 USA. RP Monroe, J (reprint author), Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM JAMonroe@cdc.gov NR 13 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 IS 1 BP 141 EP 144 DI 10.1097/PHH.0b013e3182a5a3c2 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG8TO UT WOS:000335691300037 PM 24322710 ER PT J AU Cummings, PL Kuo, T Gase, LN Mugavero, K AF Cummings, Patricia L. Kuo, Tony Gase, Lauren N. Mugavero, Kristy TI Integrating Sodium Reduction Strategies in the Procurement Process and Contracting of Food Venues in the County of Los Angeles Government, 2010-2012 SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE County; healthy food procurement; program intervention; sodium limits ID PHYSICAL-ACTIVITY; UNITED-STATES; HEALTH IMPACT; LOCAL-POLICY; CONSUMPTION; OBESITY; CHOICE; MENU AB Since sodium is ubiquitous in the food supply, recent approaches to sodium reduction have focused on increasing the availability of lower-sodium products through system-level and environmental changes. This article reviews integrated efforts by the Los Angeles County Sodium Reduction Initiative to implement these strategies at food venues in the County of Los Angeles government. The review used mixed methods, including a scan of the literature, key informant interviews, and lessons learned during 2010-2012 to assess program progress. Leveraging technical expertise and shared resources, the initiative strategically incorporated sodium reduction strategies into the overall work plan of a multipartnership food procurement program in Los Angeles County. To date, 3 County departments have incorporated new or updated nutrition requirements that included sodium limits and other strategies. The strategic coupling of sodium reduction to food procurement and general health promotion allowed for simultaneous advancement and acceleration of the County's sodium reduction agenda. C1 [Cummings, Patricia L.; Kuo, Tony; Gase, Lauren N.] Los Angeles Cty Dept Publ Hlth, Los Angeles Cty Sodium Reduct Initiat, Div Chron Dis & Injury Prevent, Los Angeles, CA 90010 USA. [Cummings, Patricia L.; Kuo, Tony; Gase, Lauren N.] Univ Calif Los Angeles, Los Angeles, CA USA. [Mugavero, Kristy] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Cummings, PL (reprint author), Los Angeles Cty Dept Publ Hlth, Los Angeles Cty Sodium Reduct Initiat, Div Chron Dis & Injury Prevent, 3530 Wilshire Blvd,8th Floor, Los Angeles, CA 90010 USA. EM pcummings@ph.lacounty.gov FU Intramural CDC HHS [CC999999]; NCCDPHP CDC HHS [U50 DP003061, U58 DP003061] NR 29 TC 3 Z9 4 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 SU 1 BP S16 EP S22 DI 10.1097/PHH.0b013e31829d7f63 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH2UU UT WOS:000335977900004 PM 24322811 ER PT J AU Losby, JL Patel, D Schuldt, J Hunt, GS Stracuzzi, JC Johnston, Y AF Losby, Jan L. Patel, Deesha Schuldt, June Hunt, Glynnis S. Stracuzzi, Jeanne C. Johnston, Yvonne TI Sodium-Reduction Strategies for Meals Prepared for Older Adults SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE nutrition; older adults; sodium; sodium reduction AB This article describes lessons learned from implementing sodium-reduction strategies in programs that provide meals to older adults in 2 New York counties, with one county replicating the approaches of the other. The implemented sodium-reduction strategies were product substitutions, recipe modifications, and cooking from scratch. Both counties were able to achieve modest sodium reductions in prepared meals. Lessons learned to implement sodium reduction strategies include the following: (1) identifying partners with shared experience and common goals; (2) engaging experts; (3) understanding the complexity of the meals system for older adults; (4) conducting sodium nutrient analysis; (5) making gradual and voluntary reductions to sodium content; and (6) working toward sustainable sodium reduction. C1 [Losby, Jan L.; Patel, Deesha] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Schuldt, June; Hunt, Glynnis S.] Schenectady Cty Publ Hlth Serv, Schenectady, NY USA. [Stracuzzi, Jeanne C.] Broome Cty Off Aging, Binghamton, NY USA. [Johnston, Yvonne] Binghamton Univ, Decker Sch Nursing, Binghamton, NY USA. RP Losby, JL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F-72, Atlanta, GA 30341 USA. EM JLosby@cdc.gov FU Intramural CDC HHS [CC999999]; NCCDPHP CDC HHS [U50 DP003064, U58 DP003064] NR 12 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 SU 1 BP S23 EP S30 DI 10.1097/PHH.0b013e3182a0e3ca PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH2UU UT WOS:000335977900005 PM 24322812 ER PT J AU Mugavero, KL Gunn, JP Dunet, DO Bowman, BA AF Mugavero, Kristy L. Gunn, Janelle P. Dunet, Diane O. Bowman, Barbara A. TI Sodium Reduction: An Important Public Health Strategy for Heart Health SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material ID UNITED-STATES; SCHOOL-DISTRICT; COUNTY; FOOD; ADULTS; CONSUMPTION; POPULATION; CALIFORNIA; POLICY; MEALS C1 [Mugavero, Kristy L.; Gunn, Janelle P.; Dunet, Diane O.; Bowman, Barbara A.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Mugavero, KL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F72, Atlanta, GA 30341 USA. EM frc9@cdc.gov FU Intramural CDC HHS [CC999999] NR 30 TC 1 Z9 1 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 SU 1 BP S1 EP S5 DI 10.1097/PHH.0b013e3182aa659c PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH2UU UT WOS:000335977900001 PM 24322810 ER PT J AU Schuldt, J Levings, JL Kahn-Marshall, J Hunt, G Mugavero, K Gunn, JP AF Schuldt, June Levings, Jessica Lee Kahn-Marshall, Jennifer Hunt, Glynnis Mugavero, Kristy Gunn, Janelle Peralez TI Reducing Sodium Across the Board: A Pilot Program in Schenectady County Independent Restaurants SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE independent restaurants; nutrition; sodium; sodium reduction AB Excess sodium intake can lead to increased blood pressure. Restaurant foods contribute nearly a quarter of the sodium consumed in the American diet. The objective of the pilot project was to develop and implement in collaboration with independent restaurants a tool, the Restaurant Assessment Tool and Evaluation (RATE), to assess efforts to reduce sodium in independent restaurants and measure changes over time in food preparation categories, including menu, cooking techniques, and products. Twelve independent restaurants in Schenectady County, New York, voluntarily participated. From initial assessment to a 6-month follow-up assessment using the RATE, 11 restaurants showed improvement in the cooking category, 9 showed improvement in the menu category, and 7 showed improvement in the product category. Menu analysis conducted by the Schenectady County Health Department staff suggested that reported sodium-reduction strategies might have affected approximately 25% of the restaurant menu items. The findings from this project suggest that a facilitated assessment, such as the RATE, can provide a useful platform for independent restaurant owners and public health practitioners to discuss and encourage sodium reduction. The RATE also provides opportunities to build and strengthen relationships between public health care practitioners and independent restaurant owners, which may help sustain the positive changes made. C1 [Schuldt, June; Hunt, Glynnis] Schenectady Cty Publ Hlth Serv, New York, NY USA. [Kahn-Marshall, Jennifer] Cornell Cooperat Extens, New York, NY USA. [Levings, Jessica Lee; Mugavero, Kristy; Gunn, Janelle Peralez] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Schuldt, J (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. EM frc9@cdc.gov NR 7 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 SU 1 BP S31 EP S37 DI 10.1097/PHH.0b013e31829d7b7c PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH2UU UT WOS:000335977900006 PM 24322813 ER PT J AU Taylor, S Tibbett, T Patel, D Bishop, E AF Taylor, Stephanie Tibbett, Theresa Patel, Deesha Bishop, Ereka TI Use of Environmental Change Strategies to Facilitate Sodium Reduction: A Case Study in a Rural California School District SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE environmental change; nutrition; rural school district; school meals; sodium content; sodium reduction ID BLOOD-PRESSURE; CHILDREN AB Context: Excess sodium consumption increases the risk for hypertension, which is a leading risk factor for cardiovascular disease. For children and teenagers, school meals are a significant source of sodium consumption. Objective: To describe the environmental change strategies that were implemented to reduce sodium in the school meals of a rural California school district. Design: Descriptions of the environmental strategies, with an emphasis on staff training and infrastructure improvements. Setting: School district of approximately two thousand 9th- to 12th-grade students in rural, northern California. Participants: School administration and food service staff at the 5 high schools in Anderson Union High School District. Intervention: Shasta County Public Health partnered with Anderson Union High School District to (1) facilitate changes to meal preparation practices, (2) improve cafeteria infrastructure, and (3) provide training and technical assistance to improve procurement strategies. Results: Environmental strategies to reduce sodium in school meals were implemented in 2011. Anderson Union High School District has continued to successfully implement scratch cooking and improve procurement strategies to reduce sodium in school meals. Conclusion: Using an approach that includes environmental change strategies can lead to sodium reduction in a school setting. C1 [Taylor, Stephanie] Shasta Cty Hlth & Human Serv Agcy, Outcomes Planning & Evaluat Div, Redding, CA 96001 USA. [Tibbett, Theresa; Bishop, Ereka] Shasta Cty Hlth & Human Serv Agcy, Hlth Commun Div, Publ Hlth Branch, Redding, CA 96001 USA. [Patel, Deesha] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Taylor, S (reprint author), Shasta Cty Hlth & Human Serv Agcy, Redding, CA 96001 USA. EM smtaylor@co.shasta.ca.us FU Intramural CDC HHS [CC999999]; NCCDPHP CDC HHS [U50 DP003071, U58 DP003071] NR 9 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2014 VL 20 SU 1 BP S38 EP S42 DI 10.1097/PHH.0b013e31829d7726 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH2UU UT WOS:000335977900007 PM 24322814 ER PT J AU Eaton, JW Menzies, NA Stover, J Cambiano, V Chindelevitch, L Cori, A Hontelez, JAC Humair, S Kerr, CC Klein, DJ Mishra, S Mitchell, KM Nichols, BE Vickerman, P Bakker, R Barnighausen, T Bershteyn, A Bloom, DE Boily, MC Chang, ST Cohen, T Dodd, PJ Fraser, C Gopalappa, C Lundgren, J Martin, NK Mikkelsen, E Mountain, E Pham, QD Pickles, M Phillips, A Platt, L Pretorius, C Prudden, HJ Salomon, JA van de Vijver, DAMC de Vlas, SJ Wagner, BG White, RG Wilson, DP Zhang, L Blandford, J Meyer-Rath, G Remme, M Revill, P Sangrujee, N Terris-Prestholt, F Doherty, M Shaffer, N Easterbrook, PJ Hirnschall, G Hallett, TB AF Eaton, Jeffrey W. Menzies, Nicolas A. Stover, John Cambiano, Valentina Chindelevitch, Leonid Cori, Anne Hontelez, Jan A. C. Humair, Salal Kerr, Cliff C. Klein, Daniel J. Mishra, Sharmistha Mitchell, Kate M. Nichols, Brooke E. Vickerman, Peter Bakker, Roel Baernighausen, Till Bershteyn, Anna Bloom, David E. Boily, Marie-Claude Chang, Stewart T. Cohen, Ted Dodd, Peter J. Fraser, Christophe Gopalappa, Chaitra Lundgren, Jens Martin, Natasha K. Mikkelsen, Evelinn Mountain, Elisa Pham, Quang D. Pickles, Michael Phillips, Andrew Platt, Lucy Pretorius, Carel Prudden, Holly J. Salomon, Joshua A. van de Vijver, David A. M. C. de Vlas, Sake J. Wagner, Bradley G. White, Richard G. Wilson, David P. Zhang, Lei Blandford, John Meyer-Rath, Gesine Remme, Michelle Revill, Paul Sangrujee, Nalinee Terris-Prestholt, Fern Doherty, Meg Shaffer, Nathan Easterbrook, Philippa J. Hirnschall, Gottfried Hallett, Timothy B. TI Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models SO LANCET GLOBAL HEALTH LA English DT Article ID HIV PREVENTION; SOUTH-AFRICA; IMPACT; RISK; SEX; ART; PREVALENCE; INFECTION; SETTINGS; HIV/AIDS AB Background New WHO guidelines recommend initiation of antiretroviral therapy for HIV-positive adults with CD4 counts of 500 cells per mu L or less, a higher threshold than was previously recommended. Country decision makers have to decide whether to further expand eligibility for antiretroviral therapy accordingly. We aimed to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy and expanded treatment coverage. Methods We used several independent mathematical models in four settings-South Africa (generalised epidemic, moderate antiretroviral therapy coverage), Zambia (generalised epidemic, high antiretroviral therapy coverage), India (concentrated epidemic, moderate antiretroviral therapy coverage), and Vietnam (concentrated epidemic, low antiretroviral therapy coverage)-to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy under scenarios of existing and expanded treatment coverage, with results projected over 20 years. Analyses assessed the extension of eligibility to include individuals with CD4 counts of 500 cells per mu L or less, or all HIV-positive adults, compared with the previous (2010) recommendation of initiation with CD4 counts of 350 cells per mu L or less. We assessed costs from a health-system perspective, and calculated the incremental cost (in US$) per disability-adjusted life-year (DALY) averted to compare competing strategies. Strategies were regarded very cost effective if the cost per DALY averted was less than the country's 2012 per-head gross domestic product (GDP; South Africa: $8040; Zambia: $1425; India: $1489; Vietnam: $1407) and cost effective if the cost per DALY averted was less than three times the per-head GDP. Findings In South Africa, the cost per DALY averted of extending eligibility for antiretroviral therapy to adult patients with CD4 counts of 500 cells per mu L or less ranged from $237 to $1691 per DALY averted compared with 2010 guidelines. In Zambia, expansion of eligibility to adults with a CD4 count threshold of 500 cells per mu L ranged from improving health outcomes while reducing costs (ie, dominating the previous guidelines) to $749 per DALY averted. In both countries results were similar for expansion of eligibility to all HIV-positive adults, and when substantially expanded treatment coverage was assumed. Expansion of treatment coverage in the general population was also cost effective. In India, the cost for extending eligibility to all HIV-positive adults ranged from $131 to $241 per DALY averted, and in Vietnam extending eligibility to patients with CD4 counts of 500 cells per mu L or less cost $290 per DALY averted. In concentrated epidemics, expanded access for key populations was also cost effective. Interpretation Our estimates suggest that earlier eligibility for antiretroviral therapy is very cost effective in low-income and middle-income settings, although these estimates should be revisited when more data become available. Scaling up antiretroviral therapy through earlier eligibility and expanded coverage should be considered alongside other high-priority health interventions competing for health budgets. C1 [Cori, Anne; Fraser, Christophe] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Outbreak Anal & Modelling, London W2 1PG, England. [Eaton, Jeffrey W.; Mishra, Sharmistha; Boily, Marie-Claude; Mountain, Elisa; Pickles, Michael; Hallett, Timothy B.] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London W2 1PG, England. [Menzies, Nicolas A.; Salomon, Joshua A.] Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, Boston, MA 02115 USA. [Chindelevitch, Leonid; Humair, Salal; Baernighausen, Till; Bloom, David E.; Salomon, Joshua A.] Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA. [Cohen, Ted] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Stover, John; Gopalappa, Chaitra; Pretorius, Carel] Futures Inst, Glastonbury, CT USA. [Cambiano, Valentina; Phillips, Andrew] UCL, Res Dept Infect & Populat Hlth, London, England. [Hontelez, Jan A. C.; Bakker, Roel; de Vlas, Sake J.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands. [Nichols, Brooke E.; van de Vijver, David A. M. C.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Virol, Rotterdam, Netherlands. [Hontelez, Jan A. C.; Baernighausen, Till] Univ KwaZulu Natal, Africa Ctr Hlth & Populat Studies, Mtubatuba, South Africa. [Hontelez, Jan A. C.; Mikkelsen, Evelinn] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, Nijmegen Int Ctr Hlth Syst Anal & Educ NICHE, NL-6525 ED Nijmegen, Netherlands. [Kerr, Cliff C.; Pham, Quang D.; Wilson, David P.; Zhang, Lei] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia. [Klein, Daniel J.; Bershteyn, Anna; Chang, Stewart T.; Wagner, Bradley G.] Inst Dis Modelling, Intellectual Ventures Lab, Bellevue, WA USA. [Mishra, Sharmistha] Univ Toronto, St Michaels Hosp, Div Infect Dis, Toronto, ON, Canada. [Mitchell, Kate M.; Vickerman, Peter; Martin, Natasha K.; Platt, Lucy; Prudden, Holly J.; Remme, Michelle; Terris-Prestholt, Fern] London Sch Hyg & Trop Med, Social & Math Epidemiol Grp, London WC1, England. [Dodd, Peter J.; White, Richard G.] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London WC1, England. [Cohen, Ted] Brigham & Womens Hosp, Div Global Hlth Equ, Boston, MA 02115 USA. [Lundgren, Jens] Copenhagen Univ Hosp, Rigshosp, Ctr Viral Dis, Dept Infect Dis, Copenhagen, Denmark. [Lundgren, Jens] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark. [Martin, Natasha K.] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England. [Blandford, John; Sangrujee, Nalinee] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Meyer-Rath, Gesine] Boston Univ, Ctr Global Hlth & Dev, Boston, MA 02215 USA. [Meyer-Rath, Gesine] Univ Witwatersrand, Dept Med, Hlth Econ & Epidemiol Res Off, Fac Hlth Sci, ZA-2001 Johannesburg, South Africa. [Revill, Paul] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England. [Doherty, Meg; Shaffer, Nathan; Easterbrook, Philippa J.; Hirnschall, Gottfried] WHO, Dept HIV AIDS, CH-1211 Geneva, Switzerland. RP Hallett, TB (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London W2 1PG, England. EM timothy.hallett@imperial.ac.uk RI Phillips, Andrew/B-4427-2008; White, Richard/D-5407-2009; Fraser, Christophe/A-8109-2008; Salomon, Joshua/D-3898-2009; OI Pickles, Michael/0000-0002-6754-3945; Mishra, Sharmistha/0000-0001-8492-5470; Eaton, Jeffrey/0000-0001-7728-728X; Phillips, Andrew/0000-0003-2384-4807; White, Richard/0000-0003-4410-6635; Fraser, Christophe/0000-0003-2399-9657; Salomon, Joshua/0000-0003-3929-5515; Gopalappa, Chaitra/0000-0001-8384-6041; Lundgren, Jens/0000-0001-8901-7850; Dodd, Pete/0000-0001-5825-9347 FU Bill & Melinda Gates Foundation; WHO; Bill and Melinda Gates through the Global Good Fund; Canadian Foundation for AIDS (CANFAR) [023-015]; Wellcome Trust [086431/Z/08/Z]; US National Institute of General Medical Sciences [U54GM088558]; World Bank; Australian Research Council; University of New South Wales; AusAID; UK Medical Research Council [G0802414, MR/J005088/1]; Bill & Melinda Gates Foundation (Consortium to Respond Effectively to the AIDS/TB Epidemic) [19790.01]; Bill & Melinda Gates Foundation (TB Modelling and Analysis Consortium) [21675]; Aids Fonds in Amsterdam, Netherlands [2010-035]; European Union FP7 CHAIN grant [223131]; UK National Institute for Health Research postdoctoral fellowship; UNAIDS India FX The study was funded by the Bill & Melinda Gates Foundation and WHO. We thank Ellen McRobie and Annick Borquez from Imperial College London (London, UK) for coordinating the HIV Modelling Consortium ART Eligibility Guidelines modelling project. We thank Mary Mahy from UNAIDS (Geneva, Switzerland) for providing additional information about UNAIDS' country-level epidemiological estimates. We thank Emmanuela Gakidou and Herbert Duber from the Institute for Health Metrics and Evaluation at the University of Washington (Seattle, WA, USA) for providing information about antiretroviral therapy programmes in South Africa and Zambia. We thank Elliot Raizes from the US Centers for Disease Control and Prevention (CDC, Atlanta, GA, USA) for input on supply-chain management costs for antiretroviral drugs. We thank the Clinton Health Access Initiative (New York, NY, USA) and the Division of Global HIV/AIDS of the CDC for access to unpublished cost estimates. VC and AP acknowledge the University College London Research Computing Services (Legion Cluster; London, UK) and input to the synthesis model from Deborah Ford, Alec Miners, Paul Revill, Fumiyo Nakagawa, and Deenan Pillay. DJK, AB, STC, and BGW thank Bill and Melinda Gates for their active support of this work and their sponsorship through the Global Good Fund. M-CB, SM, EMo, and MP thank all other members of the Strategic Epi-ART in India Modeling team for their contribution to data and model inputs. M-CB, SM, EMo, and MP acknowledge the Canadian Foundation for AIDS (CANFAR, research grant number 023-015) for funding the Belgaum modelling. KMM and HJP acknowledge funding from the Wellcome Trust (086431/Z/08/Z). TC received funding from the US National Institute of General Medical Sciences (U54GM088558; the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health). DPW, CCK, QDP, and LZ acknowledge funding from the World Bank, Australian Research Council, University of New South Wales, and AusAID. QDP acknowledges scholarship support from AusAID. RGW acknowledges research funding from the UK Medical Research Council (Methodology Research Fellowship G0802414 and grant MR/J005088/1) and the Bill & Melinda Gates Foundation (Consortium to Respond Effectively to the AIDS/TB Epidemic [19790.01] and TB Modelling and Analysis Consortium [21675]). BEN and DAMCvdV acknowledge research funding from the Aids Fonds (grant 2010-035) in Amsterdam, Netherlands, and the European Union FP7 CHAIN grant (223131). NKM acknowledges funding from a UK National Institute for Health Research postdoctoral fellowship. PV acknowledges funding support from UNAIDS India for modelling work in northeast India. The findings and conclusions in this report are those of the authors and do not necessarily represent the official positions of the CDC or WHO. NR 49 TC 64 Z9 65 U1 5 U2 20 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2214-109X J9 LANCET GLOB HEALTH JI Lancet Glob. Health PD JAN PY 2014 VL 2 IS 1 BP E23 EP E34 DI 10.1016/S2214-109X(13)70172-4 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH8YK UT WOS:000336423900015 PM 25104632 ER PT J AU Dunne, EF Flagg, EW Unger, ER Hsu, K Ghanen, K Kerndt, P Shlay, JC Koutsky, LA Datta, DS Panicker, G Zaidi, A Weinstock, H Markowitz, LE AF Dunne, Eileen F. Flagg, Elaine W. Unger, Elizabeth R. Hsu, Kathy Ghanen, Khalil Kerndt, Peter Shlay, Judy C. Koutsky, Laura A. Datta, Deblina S. Panicker, Gitika Zaidi, Akbar Weinstock, Hillard Markowitz, Lauri E. TI Would Young Women Attending Sexually Transmitted Disease Clinics Benefit From Human Papillomavirus Vaccination? An Assessment of Human Papillomavirus DNA and Seropositivity From Human Papillomavirus Sentinel Surveillance, 2003Y2005 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID HPV INFECTION; EFFICACY; STATES AB Background There are limited data on the proportion who have been exposed to vaccine-type human papillomavirus (HPV) among women attending sexually transmitted disease (STD) clinics; this information could inform the potential benefits of HPV vaccination for women attending this venue. Methods Human papillomavirus surveillance was conducted in STD clinics in Baltimore, MD; Boston, MA; Denver, CO; Los Angeles, CA; and Seattle, WA, among women receiving cervical cancer screening from January 2003 to December 2005. The women had specimens collected for cervical cytology HPV testing by L1 consensus polymerase chain reaction testing and serologic assessment for HPV 6, 11, 16, and 18 using the competitive Luminex immunoassay. Results from 880 women with adequate specimens were included. Women were HPV naive if they were both HPV DNA negative and seronegative for a specific HPV type. Results One hundred seventy women (19.3%) had HPV 16, 18, 6, or 11 DNA, and 418 (47.5%) were HPV 16, 18, 6, or 11 seropositive. Four hundred ten (46.6%) women were naive to all 4 types, 570 (64.8%) were naive to both HPV 16 and 18, and 545 (61.9%) were naive to both HPV 6 and 11. Almost all (99.3%) women were naive to at least 1 vaccine HPV type. Conclusions Almost half of young women age eligible for HPV vaccine and attending STD clinics were naive to all 4 HPV types, and more than half were naive to both HPV 16 and 18. This assessment suggests that most young women attending this venue might benefit from HPV vaccination. C1 [Dunne, Eileen F.; Flagg, Elaine W.; Unger, Elizabeth R.; Datta, Deblina S.; Panicker, Gitika; Zaidi, Akbar; Weinstock, Hillard; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hsu, Kathy] Massachusetts Dept Publ Hlth, Div STD Prevent, Boston, MA USA. [Ghanen, Khalil] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Kerndt, Peter] Cty Los Angeles Dept Hlth Serv, STD Program, Los Angeles, CA USA. [Shlay, Judy C.] Denver Publ Hlth, Denver, CO USA. [Koutsky, Laura A.] Univ Washington, Seattle, WA 98195 USA. [Datta, Deblina S.] GAVI, Geneva, Switzerland. RP Dunne, EF (reprint author), CDC, Div STD Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30333 USA. EM Dde9@cdc.gov NR 14 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2014 VL 41 IS 1 BP 46 EP 49 DI 10.1097/OLQ.0000000000000071 PG 4 WC Infectious Diseases SC Infectious Diseases GA AH5YQ UT WOS:000336207800009 PM 24326582 ER PT J AU Anschuetz, G Asbel, L Salmon, ME Johnson, CC AF Anschuetz, Greta Asbel, Lenore Salmon, Melinda E. Johnson, Caroline C. TI Use of First- Line Treatment for Neisseria gonorrhoeae After Treatment Guideline Changes SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID THREAT AB After 2 notices with treatment recommendation changes for Neisseria gonorrhoeae, the Philadelphia Department of Public Health documented medical therapy for 92% (3279/3551) of cases; 3001 (92%) received a recommended therapy. Nonrecommended therapies were documented in 8% of cases. Providers diagnosing 2 or less N. gonorrhoeae cases were more likely to use nonrecommended therapy. C1 [Anschuetz, Greta; Asbel, Lenore; Salmon, Melinda E.; Johnson, Caroline C.] Philadelphia Dept Publ Hlth, Div Dis Control, Philadelphia, PA 19146 USA. [Salmon, Melinda E.] US Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Anschuetz, G (reprint author), Philadelphia Dept Publ Hlth, 500 S Broad St, Philadelphia, PA 19146 USA. EM Greta.Anschuetz@phila.gov FU Comprehensive STD Prevention Systems Projects grant FX Funding for this analysis was made possible by funding from Comprehensive STD Prevention Systems Projects grant. NR 8 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2014 VL 41 IS 1 BP 64 EP 66 DI 10.1097/OLQ.0000000000000061 PG 3 WC Infectious Diseases SC Infectious Diseases GA AH5YQ UT WOS:000336207800013 PM 24335745 ER PT J AU Haderxhanaj, LT Gift, TL Loosier, PS Cramer, RC Leichliter, JS AF Haderxhanaj, Laura T. Gift, Thomas L. Loosier, Penny S. Cramer, Ryan C. Leichliter, Jami S. TI Trends in Receipt of Sexually Transmitted Disease Services Among Women 15 to 44 Years Old in the United States, 2002 to 2006Y2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID CHLAMYDIA AB Background To describe recent trends in the receipt of sexually transmitted disease (STD) services among women (age, 15-44 years) from 2002 to 2006-2010 using the National Survey of Family Growth. Methods We analyzed trends in demographics, health insurance, and visit-related variables of women reporting receipt of STD services (counseling, testing, or treatment) in the past 12 months. We also analyzed trends in the source of STD services and the payment method used. Results Receipt of STD services reported by women in the past 12 months increased from 2002 (12.6%) to 2006-2010 (16.0%; P < 0.001). Receipt of services did not increase among adolescents (P = 0.592). Among women receiving STD services from a private doctor/HMO, the percentage with private insurance decreased over time (74.6%-66.8%), whereas the percentage with Medicaid increased (12.8%-19.7%; P = 0.020). For women receiving STD services at a public clinic or nonprimary care facility, there were no statistically significant differences by demographics, except that fewer adolescents but more young adults reported using a public clinic over time (P = 0.038). Among women who reported using Medicaid as payment, receipt of STD services at a public clinic significantly decreased (36.8%-25.4%; P = 0.019). For women who paid for STD services with private insurance, the only significant difference was an increase in having a copay over time (61.3%-70.1%; P = 0.012). Conclusions Despite a significant increase in receipt of STD services over time, many women at risk for STDs did not receive services including adolescents. In addition, we identified important shifts in payment methods during this time frame. C1 [Haderxhanaj, Laura T.; Gift, Thomas L.; Loosier, Penny S.; Cramer, Ryan C.; Leichliter, Jami S.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Haderxhanaj, LT (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,Mailstop E-02, Atlanta, GA 30333 USA. EM LHaderxhanaj@cdc.gov FU US Department of Energy; CDC FX This research was supported, in part, by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention (CDC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC. NR 26 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2014 VL 41 IS 1 BP 67 EP 73 DI 10.1097/OLQ.0000000000000058 PG 7 WC Infectious Diseases SC Infectious Diseases GA AH5YQ UT WOS:000336207800014 PM 24335746 ER PT J AU Rukh, S Khurana, R Mickey, T Anderson, L Velasquez, C Taylor, M AF Rukh, Sana Khurana, Renuka Mickey, Tom Anderson, Larissa Velasquez, Corinne Taylor, Melanie TI Chlamydia and Gonorrhea Diagnosis, Treatment, Personnel Cost Savings, and Service Delivery Improvements After the Implementation of Express Sexually Transmitted Disease Testing in Maricopa County, Arizona SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID VISIT OPTION; INFECTIONS; EFFICIENCY; CLINICS AB Background The demand for low-cost sexually transmitted disease (STD) services in Maricopa County (Phoenix area) is high. Improved methods for STD/HIV testing are needed to increase the number of patients receiving testing. Objectives The present study sought to evaluate an STD/HIV express testing (ET) option for patients identified as being at lower risk for infection. Methods Clients reporting current STD symptoms, contact to an infected partner, or health department referral were identified via questionnaire and routed to a traditional provider visit (PV); those not reporting these situations were routed to ET (laboratory-only). Demographics, treatment completion, and treatment intervals were compared among patients diagnosed as having chlamydia and gonorrhea through ET and PV encounters in September 2008 to July 2011. Personnel costs were compared for each of the 2 visit types. The number of clinic turn-aways for the 2-month time interval before the start of the program was compared with the 2-month interval at the end of the evaluation. Results Of the 36,946 clients seen at Maricopa County Department of Public Health, 7466 (20.2%) were patients seen through express visits. Overall chlamydia and gonorrhea positivity was lower among ET patients (527/7466; 7.1%) as compared with those tested through PVs (6323/29,480; 21.4%). Treatment completion rates were comparable but were higher among patients seen through PVs (99%) as compared with ET (94%). A savings of $2936 per 1000 patients seen was achieved when 20% of clients were routed through ET. Clinic turn-aways decreased significantly, from 159 clients during the 2 months before implementation of ET to 6 patients during the last 2 months of evaluation (96% reduction). Conclusions This ET system included an effective patient routing process that provided an efficient way to increase access to STD testing among persons at lower risk, at a reduced cost per patient, while maintaining high treatment coverage. C1 [Rukh, Sana] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Phoenix, AZ 85004 USA. [Khurana, Renuka; Mickey, Tom; Velasquez, Corinne; Taylor, Melanie] Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA. [Anderson, Larissa; Taylor, Melanie] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Taylor, Melanie] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Rukh, S (reprint author), Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, 550 East Van Buren St, Phoenix, AZ 85004 USA. EM srukh@email.arizona.edu NR 13 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2014 VL 41 IS 1 BP 74 EP 78 DI 10.1097/OLQ.0000000000000070 PG 5 WC Infectious Diseases SC Infectious Diseases GA AH5YQ UT WOS:000336207800015 PM 24326585 ER PT J AU Chiu, CH Vagi, SJ Wolkin, AF Martin, JP Noe, RS AF Chiu, Cindy H. Vagi, Sara J. Wolkin, Amy F. Martin, John Paul Noe, Rebecca S. TI Evaluation of the National Weather Service Extreme Cold Warning Experiment in North Dakota SO WEATHER CLIMATE AND SOCIETY LA English DT Article DE Emergency preparedness; Field experiments; Planning; Societal impacts; Windchill AB Dangerously cold weather threatens life and property. During periods of extreme cold due to wind chill, the National Weather Service (NWS) issues wind chill warnings to prompt the public to take action to mitigate risks. Wind chill warnings are based on ambient temperatures and wind speeds. Since 2010, NWS has piloted a new extreme cold warning issued for cold temperatures in wind and nonwind conditions. The North Dakota Department of Health, NWS, and the Centers for Disease Control and Prevention collaborated in conducting household surveys in Burleigh County, North Dakota, to evaluate this new warning. The objectives of the evaluation were to assess whether residents heard the new warning and to determine if protective behaviors were prompted by the warning. This was a cross-sectional survey design using the Community Assessment for Public Health Emergency Response (CASPER) methodology to select a statistically representative sample of households from Burleigh County. From 10 to 11 April 2012, 188 door-to-door household interviews were completed. The CASPER methodology uses probability sampling with weighted analysis to estimate the number and percentage of households with a specific response within Burleigh County. The majority of households reported having heard both the extreme cold and wind chill warnings, and both warnings prompted protective behaviors. These results suggest this community heard the new warning and took protective actions after hearing the warning. C1 [Chiu, Cindy H.; Vagi, Sara J.; Wolkin, Amy F.; Noe, Rebecca S.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Martin, John Paul] NOAA, Natl Weather Serv, Weather Forecast Off, Bismarck, ND USA. RP Noe, RS (reprint author), CDC, Natl Ctr Environm Hlth, 4770 Buford Hwy,MS F-60, Atlanta, GA 30341 USA. EM rhn9@cdc.gov OI Chiu, Cindy H/0000-0003-2226-2776 FU Intramural CDC HHS [CC999999] NR 19 TC 0 Z9 0 U1 1 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1948-8327 EI 1948-8335 J9 WEATHER CLIM SOC JI Weather Clim. Soc. PD JAN PY 2014 VL 6 IS 1 BP 22 EP 31 DI 10.1175/WCAS-D-13-00023.1 PG 10 WC Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AG8CJ UT WOS:000335646000003 PM 27239260 ER PT J AU Li, CY Wen, XJ Pavkov, ME Zhao, GX Balluz, LS Ford, ES Williams, D Gotway, CA AF Li, Chaoyang Wen, Xiao-Jun Pavkov, Meda E. Zhao, Guixiang Balluz, Lina S. Ford, Earl S. Williams, Desmond Gotway, Carol A. TI Awareness of Kidney Disease among US Adults: Findings from the 2011 Behavioral Risk Factor Surveillance System SO AMERICAN JOURNAL OF NEPHROLOGY LA English DT Article DE Kidney disease; Prevalence; Awareness; Hypertension; Diabetes ID HEALTH INTERVIEW SURVEY; NATIONAL-HEALTH; RENAL-DISEASE; UNITED-STATES; PREVALENCE; POPULATION; MORTALITY; TRENDS AB Background: The prevalence of chronic kidney disease as measured by biomarkers is increasing, but the recognition for this condition remains low in the USA. Little is known about the awareness of kidney disease at the state level. Methods: Data from 490,302 adults aged 18 years or older in all 50 states as well as the District of Columbia who participated in the 2011 Behavioral Risk Factor Surveillance System were analyzed. Kidney disease diagnosis, a measure of individual awareness, was ascertained by participants' self-report in the telephone survey. Prevalence ratios of self-reported kidney disease in sub-populations were estimated and tested using log-linear regression analyses with a robust variance estimator. Results: The unadjusted prevalence of self-reported kidney disease was estimated to be 2.5%. After adjustment for age and all other selected covariates, Hispanics had a higher prevalence than non-Hispanic whites (adjusted prevalence ratio 1.2, 95% CI 1.0-1.4). Persons who were unemployed (adjusted prevalence ratio 1.4, 95% CI 1.2-1.5) had a higher prevalence than those who were employed. Persons who had hypertension (adjusted prevalence ratio 1.9, 95% CI 1.7-2.1), diabetes (adjusted prevalence ratio 1.7,95% CI 1.5-1.8), cardiovascular disease (coronary heart disease, myocardial infarction or stroke; adjusted prevalence ratio 1.5, 95% CI 1.4-1.6) or cancer (adjusted prevalence ratio 1.5,95% CI 1.3-1.6) had a higher prevalence of self-reported kidney disease than those without these conditions. Conclusion:The overall awareness of kidney disease was low in the general population. Efforts are needed to promote the awareness and early detection of kidney disease in public health services and clinical practice. (C) 2014 S. Karger AG, Basel C1 [Li, Chaoyang; Wen, Xiao-Jun; Balluz, Lina S.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30341 USA. [Pavkov, Meda E.; Williams, Desmond] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30341 USA. [Zhao, Guixiang; Ford, Earl S.; Gotway, Carol A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. RP Li, CY (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,MS F60, Atlanta, GA 30341 USA. EM cli@cdc.gov NR 22 TC 5 Z9 6 U1 0 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0250-8095 EI 1421-9670 J9 AM J NEPHROL JI Am. J. Nephrol. PY 2014 VL 39 IS 4 BP 306 EP 313 DI 10.1159/000360184 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA AH3HG UT WOS:000336013700004 PM 24732234 ER PT J AU Biggerstaff, M Jhung, MA Reed, C Garg, S Balluz, L Fry, AM Finelli, L AF Biggerstaff, M. Jhung, M. A. Reed, C. Garg, S. Balluz, L. Fry, A. M. Finelli, L. TI Impact of medical and behavioural factors on influenza-like illness, healthcare-seeking, and antiviral treatment during the 2009 H1N1 pandemic: USA, 2009-2010 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Healthcare-seeking behaviour; influenza; influenza A(H1N1)pdm09; influenza antiviral treatment ID RESPIRATORY-TRACT COMPLICATIONS; FACTOR SURVEILLANCE SYSTEM; CIGARETTE-SMOKING; UNITED-STATES; RISK-FACTOR; EPIDEMIC INFLUENZA; VACCINATION; PREVALENCE; CHILDREN; EFFICACY AB We analysed a cross-sectional telephone survey of U.S. adults to assess the impact of selected characteristics on healthcare-seeking behaviours and treatment practices of people with influenza-like illness (ILI) from September 2009 to March 2010. Of 216431 respondents, 81% reported ILI. After adjusting for selected characteristics, respondents aged 18-64 years with the following factors were more likely to report ILI: a diagnosis of asthma [adjusted odds ratio (aOR) 188, 95% CI 167-213] or heart disease (aOR 141, 95% CI 117-170), being disabled (aOR 175, 95% CI 157-196), and reporting financial barriers to healthcare access (aOR 163, 95% CI 145-182). Similar associations were seen in respondents aged 65 years. Forty percent of respondents with ILI sought healthcare, and 14% who sought healthcare reported receiving influenza antiviral treatment. Treatment was not more frequent in patients with high-risk conditions, except those aged 18-64 years with heart disease (aOR 190, 95% CI 103-351). Of patients at high risk for influenza complications, self-reported ILI was greater but receipt of antiviral treatment was not, despite guidelines recommending their use in this population. C1 [Biggerstaff, M.; Jhung, M. A.; Reed, C.; Garg, S.; Fry, A. M.; Finelli, L.] Ctr Dis Control & Prevent, Epidemiol & Prevent Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Garg, S.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Balluz, L.] Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. RP Biggerstaff, M (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE MS A-32, Atlanta, GA 30333 USA. EM MBiggerstaff@cdc.gov FU Intramural CDC HHS [CC999999] NR 38 TC 4 Z9 4 U1 1 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2014 VL 142 IS 1 BP 114 EP 125 DI 10.1017/S0950268813000654 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AC4XG UT WOS:000332523900014 PM 23522400 ER PT J AU Cardemil, CV Rathee, M Gary, H Wannemuehler, K Anand, A Mach, O Bahl, S Wassilak, S Chu, SY Khera, A Jafari, HS Pallansch, MA AF Cardemil, C. V. Rathee, M. Gary, H. Wannemuehler, K. Anand, A. Mach, O. Bahl, S. Wassilak, S. Chu, S. Y. Khera, A. Jafari, H. S. Pallansch, M. A. TI Surveillance during an era of rapidly changing poliovirus epidemiology in India: the role of one vs. two stool specimens in poliovirus detection, 2000-2010 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Infectious disease epidemiology; laboratory tests; polio; surveillance; surveillance system ID ACUTE FLACCID PARALYSIS; WILD POLIOVIRUS; ERADICATION; SENSITIVITY; AMERICA AB Since 2004, efforts to improve poliovirus detection have significantly increased the volume of specimen testing from acute flaccid paralysis (AFP) patients in India. One option to decrease collection and testing burden would be collecting only a single stool specimen instead of two. We investigated stool specimen sensitivity for poliovirus detection in India to estimate the contribution of the second specimen. We reviewed poliovirus isolation data for 303984 children aged <15 years with AFP during 2000-2010. Using maximum-likelihood estimation, we determined specimen sensitivity of each stool specimen, combined sensitivity of both specimens, and sensitivity added by the second specimen. Of 5184 AFP patients with poliovirus isolates, 382 (7.4%) were identified only by the second specimen. Sensitivity was 91.4% for the first specimen and 84.5% for the second specimen; the second specimen added 7.3% sensitivity, giving a combined sensitivity of 987%. Combined sensitivity declined, and added sensitivity increased, as the time from paralysis onset to stool collection increased (P=0.032). The sensitivity added by the second specimen is important to detect the last chains of poliovirus transmission and to achieve certification of polio eradication. For sensitive surveillance, two stool specimens should continue to be collected from each AFP patient in India. C1 [Cardemil, C. V.; Gary, H.; Wannemuehler, K.; Anand, A.; Mach, O.; Wassilak, S.; Chu, S. Y.] Ctr Dis Control & Prevent, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Cardemil, C. V.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Rathee, M.; Bahl, S.; Jafari, H. S.] World Hlth Org India, Natl Polio Surveillance Project, New Delhi, India. [Khera, A.] Govt India, Minist Hlth & Family Welf, New Delhi, India. [Pallansch, M. A.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Cardemil, CV (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM ccardemil@cdc.gov NR 20 TC 3 Z9 3 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2014 VL 142 IS 1 BP 163 EP 171 DI 10.1017/S0950268813000800 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AC4XG UT WOS:000332523900020 PM 23594458 ER PT J AU Fuhr, DC Fleischmann, A Riley, L Kann, L Poznyak, V AF Fuhr, Daniela Christina Fleischmann, Alexandra Riley, Leanne Kann, Laura Poznyak, Vladimir TI Alcohol and other psychoactive substances in Africa and the Americas: results from the WHO Global School-based Student Health Survey SO JOURNAL OF SUBSTANCE USE LA English DT Article DE Adolescence; alcohol; drugs ID UNITED-STATES; CIGARETTE USE; RISK-FACTOR; TOBACCO USE; DRUG-USE; SMOKING; CONSUMPTION; DRINKING; ADOLESCENTS; DEPENDENCE AB Objective: The objective of this study was to estimate the prevalence of current alcohol use and its association with cigarette and drug use among 13-15-year-olds in Africa and the Americas. Method: Cross-sectional data of the WHO Global School-based Student Health Survey from nine countries in the WHO African Region and seven countries/territories in the WHO Region of the Americas were analysed. Single and joint prevalence rates, and prevalence odds ratios were computed. Results: In the majority of countries, alcohol was the most often consumed psychoactive substance, with the prevalence of current alcohol use outweighing the prevalence of current cigarette and lifetime drug use. Gender differences for alcohol were not marked. The use of alcohol was strongly associated with cigarette or drug use, indicating clustering. Conclusions: For the bulk of countries in the Americas and for single countries in Africa, current alcohol use is as high as prevalence rates occurring in other parts of the world. It is imperative to monitor psychoactive substance use among adolescents in these countries to be able to prevent future health and social harm with the information gained. C1 [Fuhr, Daniela Christina] London Sch Hyg & Trop Med, Ctr Global Mental Hlth, London, England. [Fleischmann, Alexandra; Poznyak, Vladimir] WHO, Dept Mental Hlth & Subst Abuse, CH-1211 Geneva, Switzerland. [Riley, Leanne] WHO, Dept Chron Dis & Hlth Promot Surveillance & Popul, CH-1211 Geneva, Switzerland. [Kann, Laura] US Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. RP Fuhr, DC (reprint author), London Sch Hyg & Trop Med, Ctr Global Mental Hlth, London, England. EM Daniela.Fuhr@lshtm.ac.uk NR 32 TC 1 Z9 1 U1 0 U2 4 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1465-9891 EI 1475-9942 J9 J SUBST USE JI J. Subst. Use PY 2014 VL 19 IS 3 BP 274 EP 282 DI 10.3109/14659891.2013.824038 PG 9 WC Substance Abuse SC Substance Abuse GA AG5FP UT WOS:000335445200009 ER PT J AU Kitahara, CM Linet, MS Brenner, AV Wang, SS Melin, BS Wang, ZM Inskip, PD Freeman, LEB Braganza, MZ Carreon, T Feychting, M Gaziano, JM Peters, U Purdue, MP Ruder, AM Sesso, HD Shu, XO Waters, MA White, E Zheng, W Hoover, RN Fraumeni, JF Chatterjee, N Yeager, M Chanock, SJ Hartge, P Rajaraman, P AF Kitahara, Cari M. Linet, Martha S. Brenner, Alina V. Wang, Sophia S. Melin, Beatrice S. Wang, Zhaoming Inskip, Peter D. Freeman, Laura E. Beane Braganza, Melissa Z. Carreon, Tania Feychting, Maria Gaziano, J. Michael Peters, Ulrike Purdue, Mark P. Ruder, Avima M. Sesso, Howard D. Shu, Xiao-Ou Waters, Martha A. White, Emily Zheng, Wei Hoover, Robert N. Fraumeni, Joseph F., Jr. Chatterjee, Nilanjan Yeager, Meredith Chanock, Stephen J. Hartge, Patricia Rajaraman, Preetha TI Personal History of Diabetes, Genetic Susceptibility to Diabetes, and Risk of Brain Glioma: A Pooled Analysis of Observational Studies SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID GENOME-WIDE ASSOCIATION; CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; PHYSICIANS HEALTH; CANCER INCIDENCE; TUMORS; VARIANTS; MELLITUS; COHORT; LOCI AB Background: Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear. Methods: We conducted a pooled analysis of original data from five nested case-control studies and two case-control studies from the United States and China that included 962 glioma cases and 2,195 controls. We examined self-reported diabetes history in relation to glioma risk, as well as effect modification by seven glioma risk associated single-nucleotide polymorphisms(SNP). We also examined the associations between 13 diabetes risk associated SNPs, identified from genome-wide association studies, and glioma risk. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable-adjusted logistic regression models. Results: We observed a 42% reduced risk of glioma for individuals with a history of diabetes (OR = 0.58; 95% CI, 0.40-0.84). The association did not differ by sex, study design, or after restricting to glioblastoma, the most common histological subtype. We did not observe any significant per-allele trends among the 13 diabetes related SNPs examined in relation to glioma risk. Conclusion: These results support an inverse association between diabetes history and glioma risk. The role of genetic susceptibility to diabetes cannot be excluded, and should be pursued in future studies together with other factors that might be responsible for the diabetes-glioma association. Impact: These data suggest the need for studies that can evaluate, separately, the association between type 1 and type 2 diabetes and subsequent risk of adult glioma. Cancer Epidemiol Biomarkers Prev; 23(1); 47-54. (C) 2013 AACR. C1 [Kitahara, Cari M.; Linet, Martha S.; Brenner, Alina V.; Wang, Zhaoming; Inskip, Peter D.; Freeman, Laura E. Beane; Braganza, Melissa Z.; Purdue, Mark P.; Hoover, Robert N.; Fraumeni, Joseph F., Jr.; Chatterjee, Nilanjan; Yeager, Meredith; Chanock, Stephen J.; Hartge, Patricia; Rajaraman, Preetha] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Wang, Zhaoming; Yeager, Meredith; Chanock, Stephen J.] SAIC Frederick Inc, Core Genotyping Facil, NCI, Gaithersburg, MD USA. [Wang, Sophia S.] City Hope & Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA. [Carreon, Tania; Ruder, Avima M.; Waters, Martha A.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Brigham & Womens Hosp, Div Prevent Med, Sch Med, Boston, MA 02115 USA. [Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Brigham & Womens Hosp, Div Aging, Sch Med, Boston, MA 02115 USA. [Gaziano, J. Michael] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Res & Informat Ctr, Massachusetts Vet Epidemiol, Boston, MA USA. [Peters, Ulrike] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Peters, Ulrike; White, Emily] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Melin, Beatrice S.] Umea Univ, Dept Radiat Sci, Umea, Sweden. [Feychting, Maria] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. RP Kitahara, CM (reprint author), Div Canc Epidemiol & Genet, 9609 Med Ctr Dr,Room 7E-566, Bethesda, MD 20892 USA. EM meinholdc@mail.nih.gov RI Purdue, Mark/C-9228-2016; Kitahara, Cari/R-8267-2016 OI Purdue, Mark/0000-0003-1177-3108; FU National Institutes of Health [CA 97193, CA 34944, CA 40360, HL 26490, HL 34595]; Division of Cancer Epidemiology and Genetics; Division of Cancer Prevention; National Cancer Institute; NIH; DHHS; NIOSH operating funds; National Cancer Institute [K05CA154337]; NIH Office of Dietary Supplements FX The authors thank all investigators who contributed data for the GliomaScan study.; For PHS: The PHS is supported by grants CA 97193, CA 34944, CA 40360, HL 26490, and HL 34595 from the National Institutes of Health. For PLCO: This research was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS.; For NIOSH: This research was supported by NIOSH operating funds. The contributions of former laboratory director Mary Ann Butler are gratefully acknowledged. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.; For VITAL: Grant K05CA154337 is funded by the National Cancer Institute (NCI) and the NIH Office of Dietary Supplements (ODS). NR 37 TC 10 Z9 10 U1 0 U2 7 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2014 VL 23 IS 1 BP 47 EP 54 DI 10.1158/1055-9965.EPI-13-0913 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AG0ZB UT WOS:000335143400006 PM 24220915 ER PT J AU Tauxe, RV AF Tauxe, Robert V. TI Cholera: fourth year of the epidemic in Haiti; sixth decade of the global pandemic SO PATHOGENS AND GLOBAL HEALTH LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. RP Tauxe, RV (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, MS C-09,1600 Clifton Rd, Atlanta, GA 30333 USA. EM rvt1@cdc.gov NR 5 TC 0 Z9 0 U1 0 U2 4 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 2047-7724 EI 2047-7732 J9 PATHOG GLOB HEALTH JI Pathog. Glob. Health PD JAN PY 2014 VL 108 IS 1 BP 1 EP 2 DI 10.1179/2047772413Z.000000000168 PG 2 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA AG5ET UT WOS:000335442900001 PM 24548153 ER PT J AU Ali, A Jafri, RZ Messonnier, N Tevi-Benissan, C Durrheim, D Eskola, J Fermon, F Klugman, KP Ramsay, M Sow, S Shao, ZJ Bhutta, Z Abramson, J AF Ali, Asad Jafri, Rabab Zehra Messonnier, Nancy Tevi-Benissan, Carol Durrheim, David Eskola, Juhani Fermon, Florence Klugman, Keith P. Ramsay, Mary Sow, Samba Shao Zhujun Bhutta, Zulfiqar Abramson, Jon TI Global practices of meningococcal vaccine use and impact on invasive disease SO PATHOGENS AND GLOBAL HEALTH LA English DT Review DE Invasive meningococcal disease; Epidemiology; Vaccines; Immunization schedule; Meningococcemia; Serogroup; Global; Immunity; Meningococcus; Meningitis ID C CONJUGATE VACCINE; MEMBRANE VESICLE VACCINE; RANDOMIZED CONTROLLED-TRIAL; MENINGITIDIS SEROGROUP-C; NEISSERIA-MENINGITIDIS; POLYSACCHARIDE VACCINE; UNITED-KINGDOM; IMMUNOLOGICAL MEMORY; GROUP-A; ANTIBODY PERSISTENCE AB A number of countries now include meningococcal vaccines in their routine immunization programs. This review focuses on different approaches to including meningococcal vaccines in country programs across the world and their effect on the burden of invasive meningococcal disease (IMD) as reflected by pre and post-vaccine incidence rates in the last 20 years. Mass campaigns using conjugated meningococcal vaccines have lead to control of serogroup C meningococcal disease in the UK, Canada, Australia, Spain, Belgium, Ireland, and Iceland. Serogroup B disease, predominant in New Zealand, has been dramatically decreased, partly due to the introduction of an outer membrane vesicle (OMV) vaccine. Polysaccharide vaccines were used in high risk people in Saudi Arabia and Syria and in routine immunization in China and Egypt. The highest incidence region of the meningitis belt initiated vaccination with the serogroup A conjugate vaccine in 2010 and catch-up vaccination is ongoing. Overall results of this vaccine introduction are encouraging especially in countries with a moderate to high level of endemic disease. Continued surveillance is required to monitor effectiveness in countries that recently implemented these programs. C1 [Ali, Asad; Jafri, Rabab Zehra] Aga Khan Univ, Dept Paediat & Child Hlth, Karachi, Pakistan. [Jafri, Rabab Zehra] Univ Illinois, Chicago, IL USA. [Messonnier, Nancy] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tevi-Benissan, Carol] WHO, CH-1211 Geneva, Switzerland. [Durrheim, David] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW 2308, Australia. [Eskola, Juhani] Finnish Natl Inst Hlth & Welf THL, Helsinki, Finland. [Fermon, Florence] Med Sans Frontieres, Int Vaccinat Working Grp, Paris, France. [Klugman, Keith P.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Klugman, Keith P.] Univ Witwatersrand, Johannesburg, South Africa. [Klugman, Keith P.] MRC, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Ramsay, Mary] Hlth Protect Agcy, Ctr Infect Colindale, Immunisat Dept, London, England. [Sow, Samba] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Bhutta, Zulfiqar] Aga Khan Univ, Div Women & Child Hlth, Karachi, Pakistan. [Abramson, Jon] Wake Forest Med Sch, Winston Salem, NC USA. RP Ali, A (reprint author), Aga Khan Univ, Dept Paediat & Child Hlth, Stadium Rd, Karachi, Pakistan. EM asad.ali@aku.edu FU World Health Organization [001] NR 84 TC 14 Z9 15 U1 0 U2 7 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 2047-7724 EI 2047-7732 J9 PATHOG GLOB HEALTH JI Pathog. Glob. Health PD JAN PY 2014 VL 108 IS 1 BP 11 EP 20 DI 10.1179/2047773214Y.0000000126 PG 10 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA AG5ET UT WOS:000335442900004 PM 24548156 ER PT J AU Hojgaard, A Lukacik, G Piesman, J AF Hojgaard, Andrias Lukacik, Gary Piesman, Joseph TI Detection of Borrelia burgdorferi, Anaplasma phagocytophilum and Babesia microti, with two different multiplex PCR assays SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Multiplex PCR; Ticks; Pathogens ID TICKS AB We have developed 2 real-time multiplex PCR assays for detection of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti. The efficiency and sensitivity of each multiplex PCR assay was evaluated using field-collected Ixodes scapularis ticks that were positive for each of the pathogens, cloned plasmids harboring each of the PCR targets, and laboratory I. scapularis infected with B. burgdorferi B31. There was no difference in efficiency or sensitivity when comparing the multiplex PCR with the individual PCR reactions. If the 2 multiplex PCR assays are used in the same analysis, field-collected ticks that only harbor B. miyamotoi can also be identified. The multiplex assays are fast and cost-effective methods for screening and detecting pathogens in ticks, when compared to single-target PCR. Published by Elsevier GmbH. C1 [Hojgaard, Andrias; Piesman, Joseph] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80521 USA. [Lukacik, Gary] New York State Dept Hlth, Bur Communicable Dis Control, Albany, NY USA. RP Hojgaard, A (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM Fth3@cdc.gov NR 7 TC 16 Z9 16 U1 1 U2 11 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2014 VL 5 IS 3 BP 349 EP 351 DI 10.1016/j.ttbdis.2013.12.001 PG 3 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA AG2ZS UT WOS:000335286200020 PM 24507434 ER PT J AU Tucker, SP AF Tucker, Samuel P. TI Development, evaluation and comparison of two independent sampling and analytical methods for ortho-phthalaldehyde vapors and condensation aerosols in air SO ANALYTICAL METHODS LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; ANAPHYLAXIS FOLLOWING CYSTOSCOPY; 2,4-DINITROPHENYLHYDRAZINE-IMPREGNATED SILICA; DISINFECTION; CARTRIDGE; OZONE AB Two independent sampling and analytical methods for ortho-phthalaldehyde (OPA) in air have been developed, evaluated and compared: (1) a reagent-coated solid sorbent HPLC-UV method and (2) an impinger-fluorescence method. In the first method, air sampling is conducted at 1.0 L min(-1) with a sampler containing 350 mg of silica gel coated with 1 mg of acidified 2,4-dinitrophenylhydrazine (DNPH). After sampling, excess DNPH in ethyl acetate is added to the sampler prior to storage for 68 hours. The OPA-DNPH derivative is eluted with 4.0 mL of dimethyl sulfoxide (DMSO) for measurement by HPLC with a UV detector set at 385 nm. The estimated detection limit is 0.016 mu g per sample or 0.067 mu g m(-3) (0.012 ppb) for a 240 L air sample. Recoveries of vapor spikes at levels of 1.2 to 6.2 mu g were 96 to 101%. Recoveries of spikes as mixtures of vapor and condensation aerosols were 97 to 100%. In the second method, air sampling is conducted at 1.0 L min(-1) with a midget impinger containing 10 mL of DMSO solution containing N-acetyl-L-cysteine and ethylenediamine. The fluorescence reading is taken 80 min after the completion of air sampling. Since the time of taking the fluorescence reading is critical, the reading is taken with a portable fluorometer. The estimated detection limit is 0.024 mu g per sample or 0.1 mu g m(-3) (0.018 ppb) for a 240 L air sample. Recoveries of OPA vapor spikes at levels of 1.4 to 5.0 mu g per sample were 97 to 105%. Recoveries of spikes as mixtures of vapors and condensation aerosols were 95 to 99%. The collection efficiency for a mixture of vapor and condensation aerosol was 99.4%. The two methods were compared side-by-side in a generation system constructed for producing controlled atmospheres of OPA vapor in air. Average air concentrations of OPA vapor found by both methods agreed within +/- 10%. C1 NIOSH, Cincinnati, OH 45226 USA. RP Tucker, SP (reprint author), NIOSH, Cincinnati, OH 45226 USA. EM sptucker@fuse.net NR 23 TC 0 Z9 0 U1 1 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2014 VL 6 IS 8 BP 2592 EP 2607 DI 10.1039/c3ay42085j PG 16 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA AD8NZ UT WOS:000333524200024 ER PT J AU Knaack, JS Hamelin, EI Magnuson, M Silvestri, E Ash, D Johnson, RC AF Knaack, Jennifer S. Hamelin, Elizabeth I. Magnuson, Matthew Silvestri, Erin Ash, Doris Johnson, Rudolph C. TI Quantitative analysis and stability of the rodenticide TETS (tetramine) in finished tap water SO ANALYTICAL METHODS LA English DT Article ID CHROMATOGRAPHY-MASS-SPECTROMETRY; GAS-CHROMATOGRAPHY; HUMAN BLOOD; TETRAMETHYLENE DISULFOTETRAMINE; GC FPD; TETRAMETHYLENEDISULFOTETRAMINE; FOOD; PHARMACOLOGY; AGENT AB The determination of the rodenticide tetramethylenedisulfotetramine (TETS) in drinking water is reportable through the use of automated sample preparation via solid phase extraction and detection using isotope dilution gas chromatography-mass spectrometry. The method was characterized over twenty-two analytical batches with quality control samples. Accuracies for low and high concentration quality control pools were 100 and 101%, respectively. The minimum reporting level (MRL) for TETS in this method is 0.50 mu g L-1. Five drinking waters representing a range of water quality parameters and disinfection practices were fortified with TETS at ten times the MRL and analyzed over a 28 day period to determine the stability of TETS in these waters. The amount of TETS measured in these samples averaged 100 +/- 6% of the amount fortified suggesting that tap water samples may be held for up to 28 days prior to analysis. C1 [Knaack, Jennifer S.; Hamelin, Elizabeth I.; Ash, Doris; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Magnuson, Matthew; Silvestri, Erin] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. RP Johnson, RC (reprint author), Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-44, Atlanta, GA 30341 USA. EM RJohnson6@cdc.gov FU USEPA, through its Office of Research and Development; CDC; EPA [DW75-92259701] FX The authors would like to thank Benjamin Ku for assisting with graphical editing. The research described herein has been peer and administratively reviewed and has been approved for publication as a joint U.S. Environmental Protection Agency (EPA) and Centers for Disease Control and Prevention (CDC) document. The USEPA, through its Office of Research and Development, funded and collaborated with the CDC in the research described herein under EPA IA# DW75-92259701. Note that approval does not signify that the contents necessarily reflect the views of the USEPA, the CDC, the Public Health Service, or the US Department of Health and Human Services. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States government. The views and opinions expressed herein do not necessarily state or reflect those of the United States government and shall not be used for advertising or product endorsement purposes. NR 29 TC 0 Z9 0 U1 2 U2 11 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2014 VL 6 IS 8 BP 2780 EP 2784 DI 10.1039/c3ay41912f PG 5 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA AD8NZ UT WOS:000333524200049 ER PT J AU Jagannathan, P Eccles-James, I Bowen, K Nankya, F Auma, A Wamala, S Ebusu, C Muhindo, MK Arinaitwe, E Briggs, J Greenhouse, B Tappero, JW Kamya, MR Dorsey, G Feeney, ME AF Jagannathan, Prasanna Eccles-James, Ijeoma Bowen, Katherine Nankya, Felistas Auma, Ann Wamala, Samuel Ebusu, Charles Muhindo, Mary K. Arinaitwe, Emmanuel Briggs, Jessica Greenhouse, Bryan Tappero, Jordan W. Kamya, Moses R. Dorsey, Grant Feeney, Margaret E. TI IFN gamma/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children SO PLOS PATHOGENS LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; REGULATORY T-CELLS; IFN-GAMMA; CLINICAL MALARIA; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE INOCULATION; LYMPHATIC FILARIASIS; IMMUNE-RESPONSES; IL-10 PRODUCTION; VIRAL CLEARANCE AB Although evidence suggests that T cells are critical for immunity to malaria, reliable T cell correlates of exposure to and protection from malaria among children living in endemic areas are lacking. We used multiparameter flow cytometry to perform a detailed functional characterization of malaria-specific T cells in 78 four-year-old children enrolled in a longitudinal cohort study in Tororo, Uganda, a highly malaria-endemic region. More than 1800 episodes of malaria were observed in this cohort, with no cases of severe malaria. We quantified production of IFN, TNF, and IL-10 (alone or in combination) by malaria-specific T cells, and analyzed the relationship of this response to past and future malaria incidence. CD4(+) T cell responses were measurable in nearly all children, with the majority of children having CD4(+) T cells producing both IFN and IL-10 in response to malaria-infected red blood cells. Frequencies of IFN/IL10 co-producing CD4(+) T cells, which express the Th1 transcription factor T-bet, were significantly higher in children with 2 prior episodes/year compared to children with <2 episodes/year (P<0.001) and inversely correlated with duration since malaria (Rho=-0.39, P<0.001). Notably, frequencies of IFN/IL10 co-producing cells were not associated with protection from future malaria after controlling for prior malaria incidence. In contrast, children with <2 prior episodes/year were significantly more likely to exhibit antigen-specific production of TNF without IL-10 (P=0.003). While TNF-producing CD4(+) T cells were not independently associated with future protection, the absence of cells producing this inflammatory cytokine was associated with the phenotype of asymptomatic infection. Together these data indicate that the functional phenotype of the malaria-specific T cell response is heavily influenced by malaria exposure intensity, with IFN/IL10 co-producing CD4(+) T cells dominating this response among highly exposed children. These CD4(+) T cells may play important modulatory roles in the development of antimalarial immunity. Author Summary Despite reports of decreasing malaria morbidity across many parts of Africa, the incidence of malaria among children continues to be very high in Uganda, even in the setting of insecticide-treated bednets and artemisinin-based combination therapy. Additional control measures, including a vaccine, are sorely needed in these settings, but progress has been limited by our lack of understanding of immunologic correlates of exposure and protection. T cell responses to malaria are thought to be important for protection in experimental models, but their role in protecting against naturally acquired infection is not clear. In this study, we performed detailed assessments of the malaria-specific T cell response among 4-year-old children living in Tororo, Uganda, an area of high malaria transmission. We found that recent malaria infection induces a malaria-specific immune response dominated by Th1 T cells co-producing IFN and IL-10, and that these cells are not associated with protection from future infection. IFN/IL-10 co-producing cells have been described in several parasitic infections and are hypothesized to be important in limiting CD4-mediated pathology, but they may also prevent the development of sterilizing immunity. These observations have important implications for understanding the pathophysiology of malaria in humans and for malaria vaccine development. C1 [Jagannathan, Prasanna; Eccles-James, Ijeoma; Bowen, Katherine; Briggs, Jessica; Greenhouse, Bryan; Dorsey, Grant; Feeney, Margaret E.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA 94143 USA. [Nankya, Felistas; Auma, Ann; Wamala, Samuel; Ebusu, Charles; Muhindo, Mary K.; Arinaitwe, Emmanuel] Infect Dis Res Collaborat, Kampala, Uganda. [Tappero, Jordan W.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. [Kamya, Moses R.] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda. [Feeney, Margaret E.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA. RP Feeney, ME (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA 94143 USA. EM margaret.feeney@ucsf.edu OI Greenhouse, Bryan/0000-0003-0287-9111 FU Centers for Disease Control and Prevention [U62P024421]; NIH/NIAID [R01AI093615, U19AI089674, K23 AI100949]; UCSF Centers for AIDS Research [P30AI027763]; Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene; National Center for Advancing Translational Sciences/NIH, through UCSF-CTSI [UL1 TR000004] FX This work was supported by the Centers for Disease Control and Prevention (Cooperative Agreement No U62P024421); NIH/NIAID R01AI093615 (MEF), UCSF Centers for AIDS Research (Supplement to MEF, P30AI027763), NIH/NIAID U19AI089674 (GD), NIH/NIAID K23 AI100949 (PJ), and Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene (PJ). Additional support was provided by the National Center for Advancing Translational Sciences/NIH, through UCSF-CTSI Grant Number UL1 TR000004. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the NIH. NR 91 TC 36 Z9 36 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JAN PY 2014 VL 10 IS 1 AR e1003864 DI 10.1371/journal.ppat.1003864 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AC6NQ UT WOS:000332640900031 PM 24415936 ER PT J AU Azziz-Baumgartner, E Homaira, N Hamadani, JD Tofail, F Dahlberg, LL Haque, R Luby, SP Naved, RT AF Azziz-Baumgartner, Eduardo Homaira, Nusrat Hamadani, J. D. Tofail, Fahmida Dahlberg, Linda L. Haque, Rashidul Luby, Stephen P. Naved, Ruchira T. TI The Prevalence and Impact of Intimate Partner Violence on Maternal Distress in a Community of Low-Income Bangladeshi and Displaced Ethnic Bihari Mothers: Dhaka, 2008-2009 SO VIOLENCE AGAINST WOMEN LA English DT Article DE Bangladesh; intimate partner violence prevalence rates ID DOMESTIC VIOLENCE; MENTAL-HEALTH; WOMENS HEALTH; PREGNANCY; MULTICOUNTRY; WEIGHT; ABUSE AB Low-income, ethnic, and/or displaced mothers are frequently victimized; we explored the burden of intimate partner violence (IPV) among such women. Teams administered IPV and maternal distress questionnaires to quantify victimization after the birth of a child. Of 250 mothers reporting abuse, 133 (53%) reported their husband hitting; 111 (44%) kicking, dragging, or beating; 61 (24%) choking or burning; and 33 (13%) injuring them with a knife or gun (12 case-patients per 100 person-years). Women who experienced more forms of victimization reported more distress (p = .01). Mothers in this low-income community experienced severe victimization and distress. C1 [Azziz-Baumgartner, Eduardo; Dahlberg, Linda L.; Luby, Stephen P.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Azziz-Baumgartner, Eduardo; Homaira, Nusrat; Hamadani, J. D.; Tofail, Fahmida; Haque, Rashidul; Luby, Stephen P.; Naved, Ruchira T.] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. RP Azziz-Baumgartner, E (reprint author), US Ctr Dis Control & Prevent, 1600 Clifton Rd.,NE,MS A32, Atlanta, GA 30333 USA. EM eha9@cdc.gov OI Luby, Stephen/0000-0001-5385-899X FU NCPDCID CDC HHS [U01/CI000628-02]; NIAID NIH HHS [5R01 AI043596] NR 30 TC 1 Z9 1 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 EI 1552-8448 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD JAN PY 2014 VL 20 IS 1 BP 59 EP 73 DI 10.1177/1077801213520579 PG 15 WC Women's Studies SC Women's Studies GA AB3KS UT WOS:000331690300005 PM 24567536 ER PT J AU Elliott, JC Aharonoyich, E O'Leary, A Wainberg, M Hasin, DS AF Elliott, Jennifer C. Aharonoyich, Efrat O'Leary, Ann Wainberg, Milton Hasin, Deborah S. TI Drinking motives as prospective predictors of outcome in an intervention trial with heavily drinking HIV patients SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE HIV; AIDS; Drinking; Alcohol; Prediction; Motives ID ALCOHOL-USE DISORDER; INTERVIEW SCHEDULE AUDADIS; ACTIVE ANTIRETROVIRAL THERAPY; RANDOMIZED CONTROLLED-TRIAL; GENERAL-POPULATION SAMPLE; SUBSTANCE USE; DSM-IV; INFECTED PATIENTS; UNITED-STATES; BEHAVIORAL INTERVENTION AB Background: Heavy alcohol consumption in HIV patients is an increasing health concern. Applying the drinking motivational model to HIV primary care patients, drinking motives (drinking to cope with negative affect, for social facilitation, and in response to social pressure) were associated with alcohol consumption at a baseline interview. However, whether these motives predict continued heavy drinking or alcohol dependence in this population is unknown. Methods: Participants were 254 heavy-drinking urban HIV primary care patients (78.0% male; 94.5% African American or Hispanic) participating in a randomized trial of brief drinking-reduction interventions. Drinking motive scales, as well as measures of alcohol consumption and alcohol dependence, were administered at baseline. Consumption and dependence measures were re-administered at the end of treatment two months later. Regression analyses tested whether baseline drinking motive scale scores predicted continued heavy drinking and alcohol dependence status at the end of treatment, and whether motives interacted with treatment condition. Results: Baseline drinking to cope with negative affect predicted continued heavy drinking (p < 0.05) and alcohol dependence, the latter in both in the full sample (adjusted odds ratio [AOR] = 2.14) and among those with baseline dependence (AOR = 2.52). Motives did not interact with treatment condition in predicting alcohol outcomes. Conclusions: Drinking to cope with negative affect may identify HIV patients needing targeted intervention to reduce drinking, and may inform development of more effective interventions addressing ways other than heavy drinking to cope with negative affect. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Elliott, Jennifer C.; Hasin, Deborah S.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10032 USA. [Aharonoyich, Efrat; Wainberg, Milton; Hasin, Deborah S.] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA. [Aharonoyich, Efrat; Wainberg, Milton; Hasin, Deborah S.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [O'Leary, Ann] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Hasin, DS (reprint author), Columbia Univ, Dept Psychiat, Coll Phys & Surg, 1051 Riverside Dr 123, New York, NY 10032 USA. EM dsh2@columbia.edu FU New York State Psychiatric Institute; [R01AA014323]; [K05AA014223]; [R01DA024606]; [T32DA031099] FX This study was funded by grants R01AA014323, K05AA014223, R01DA024606, T32DA031099, and the New York State Psychiatric Institute. NR 45 TC 8 Z9 8 U1 2 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD JAN 1 PY 2014 VL 134 BP 290 EP 295 DI 10.1016/j.drugalcdep.2013.10.026 PG 6 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA AC3MI UT WOS:000332425500039 PM 24286967 ER PT J AU Anderson, VP Chun, H AF Anderson, Vern Putz Chun, Heekyoung TI WORKPLACE HAZARDS AND PREVENTION OPTIONS FROM A NONRANDOM SAMPLE OF RETAIL TRADE BUSINESSES SO INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS LA English DT Article DE hazards; interventions; engineering controls; ergonomics; manual materials handling ID SAFETY CLIMATE; BACK INJURY; WORKERS; INTERVENTION; EQUIPMENT; PAIN AB Employer commitment is a key factor in an effective safety program, yet limited research has focused on the safety priorities of retail store managers. To address this, the U.S. National Institute for Occupational Safety and Health recruited 4 experienced ergonomists, who met and interviewed 9 retailers in different parts of the eastern USA. The reports from the 9 interviews were used to document the hazards facing retailers and the interventions they attempted. Those interviewed were managers/owners of establishments that ranged from a small bakery with 11 employees to a supermarket with 85 or more employees. The main hazards across all establishments included overexertion, contact-with-objects, and falls-to-the-same-level. We also compared the retailers' perceptions of safety hazards with injuries from actual hazards as supplied by the U.S. Bureau of Labor Statistics. This report provides insight into the retailers' perceptions of safety hazards as well as their commitment to the prevention of workplace injuries. C1 [Anderson, Vern Putz; Chun, Heekyoung] NIOSH, Cincinnati, OH 45226 USA. RP Anderson, VP (reprint author), NIOSH, 4676 Columbia Pwky, Cincinnati, OH 45226 USA. EM vep1@cdc.gov FU Intramural CDC HHS [CC999999] NR 42 TC 0 Z9 0 U1 2 U2 8 PU CENTRAL INST LABOUR PROTECTION-NATL RESEARCH INST PI WARSAW PA UL CZERNIAKOWSKA 16, WARSAW, 00-701, POLAND SN 1080-3548 J9 INT J OCCUP SAF ERGO JI Int. J. Occup. Saf. Ergon. PY 2014 VL 20 IS 1 BP 181 EP 195 PG 15 WC Ergonomics; Public, Environmental & Occupational Health SC Engineering; Public, Environmental & Occupational Health GA AD7XC UT WOS:000333479800017 PM 24629880 ER PT J AU Josset, L Zeng, H Kelly, SM Tumpey, TM Katze, MG AF Josset, Laurence Zeng, Hui Kelly, Sara M. Tumpey, Terrence M. Katze, Michael G. TI Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options SO MBIO LA English DT Article ID BRONCHIAL EPITHELIAL-CELLS; SEQUENCE-ANALYSIS; RECEPTOR-BINDING; HUMAN INFECTIONS; REPLICATION; MINOCYCLINE; TRANSMISSION; RESISTANCE; OUTBREAK; FERRETS AB A novel avian-origin H7N9 influenza A virus (IAV) emerged in China in 2013, causing mild to lethal human respiratory infections. H7N9 originated with multiple reassortment events between avian viruses and carries genetic markers of human adaptation. Determining whether H7N9 induces a host response closer to that with human or avian IAV is important in order to better characterize this emerging virus. Here we compared the human lung epithelial cell response to infection with A/Anhui/01/13 (H7N9) or highly pathogenic avian-origin H5N1, H7N7, or human seasonal H3N2 IAV. The transcriptomic response to H7N9 was highly specific to this strain but was more similar to the response to human H3N2 than to that to other avian IAVs. H7N9 and H3N2 both elicited responses related to eicosanoid signaling and chromatin modification, whereas H7N9 specifically induced genes regulating the cell cycle and transcription. Among avian IAVs, the response to H7N9 was closest to that elicited by H5N1 virus. Host responses common to H7N9 and the other avian viruses included the lack of induction of the antigen presentation pathway and reduced proinflammatory cytokine induction compared to that with H3N2. Repression of these responses could have an important impact on the immunogenicity and virulence of H7N9 in humans. Finally, using a genome-based drug repurposing approach, we identified several drugs predicted to regulate the host response to H7N9 that may act as potential antivirals, including several kinase inhibitors, as well as FDA-approved drugs, such as troglitazone and minocycline. Importantly, we validated that minocycline inhibited H7N9 replication in vitro, suggesting that our computational approach holds promise for identifying novel antivirals. IMPORTANCE Whether H7N9 will be the next pandemic influenza virus or will persist and sporadically infect humans from its avian reservoir, similar to H5N1, is not known yet. High-throughput profiling of the host response to infection allows rapid characterization of virus-host interactions and generates many hypotheses that will accelerate understanding and responsiveness to this potential threat. We show that the cellular response to H7N9 virus is closer to that induced by H3N2 than to that induced by H5N1, reflecting the potential of this new virus for adaptation to humans. Importantly, dissecting the host response to H7N9 may guide host-directed antiviral development. C1 [Josset, Laurence; Kelly, Sara M.; Katze, Michael G.] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA. [Zeng, Hui; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Katze, MG (reprint author), Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA. EM honey@u.washington.edu RI Josset, Laurence/A-7960-2015 OI Josset, Laurence/0000-0002-7158-1186 FU NIH, NIAID network of Centers of Excellence in Influenza Research and Surveillance (CEIRS) [HHSN266200700008C] FX This project has been funded in whole or in part with federal funds from the NIH, NIAID network of Centers of Excellence in Influenza Research and Surveillance (CEIRS), under contract HHSN266200700008C. NR 47 TC 10 Z9 10 U1 0 U2 21 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JAN-FEB PY 2014 VL 5 IS 1 AR e01102-13 DI 10.1128/mBio.01102-13 PG 12 WC Microbiology SC Microbiology GA AC4YF UT WOS:000332526500028 PM 24496798 ER PT J AU Luckhaupt, SE Sweeney, MH Sestito, JP Calvert, GM AF Luckhaupt, Sara E. Sweeney, Marie H. Sestito, John P. Calvert, Geoffrey M. TI What is the true prevalence of carpal tunnel syndrome among US workers? SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH LA English DT Letter C1 [Luckhaupt, Sara E.; Sweeney, Marie H.; Sestito, John P.; Calvert, Geoffrey M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Luckhaupt, Sara E.] NIOSH, Cincinnati, OH 45226 USA. RP Luckhaupt, SE (reprint author), NIOSH, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM sluckhaupt@cdc.gov NR 2 TC 1 Z9 1 U1 1 U2 2 PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH PI HELSINKI PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND SN 0355-3140 EI 1795-990X J9 SCAND J WORK ENV HEA JI Scand. J. Work Environ. Health PD JAN PY 2014 VL 40 IS 1 BP 100 EP 100 DI 10.5271/sjweh.3391 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AD5VN UT WOS:000333321400012 PM 24121819 ER PT J AU West, CA Galloway, E Niemeier, MT AF West, Christine A. Galloway, Ellen Niemeier, Maureen T. TI Resident Aggression Toward Staff at a Center for the Developmentally Disabled SO WORKPLACE HEALTH & SAFETY LA English DT Article ID WORK-ENVIRONMENT; MINNESOTA NURSES; NURSING-HOMES; HEALTH; INJURIES; IMPACT; VIOLENCE; CONSEQUENCES; ORGANIZATION; OVERTIME AB Few studies have examined factors contributing to nonfatal assaults to staff working in residential care facilities. The authors evaluated resident assaults toward direct care/nursing staff at an Intermediate Care Facility for Individuals with Mental Retardation (ICF/MR), which included observations of work areas, employee interviews, calculation of injury and assault rates for 2004 to 2007 from Occupational Safety and Health Administration Logs, and review of state ICF/MR guidelines. Most staff interviewed reported having been injured during physical restraint of a resident and the average rate of injury from assault at the center evaluated was higher than the average national rates for the health care and social assistance sector for the same time period. The center lacked policies for a safe workplace. The authors recommended review and maintenance of workplace violence prevention policies and developing a post-incident response and evaluation program to assist staff in coping with the consequences of assault and/or occupational injury. C1 [West, Christine A.; Galloway, Ellen; Niemeier, Maureen T.] NIOSH, Cincinnati, OH 43236 USA. RP West, CA (reprint author), NIOSH, 3135 S Whitetree Circle, Cincinnati, OH 43236 USA. EM cawest@cdc.gov FU Intramural CDC HHS [CC999999] NR 40 TC 0 Z9 0 U1 1 U2 8 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 2165-0799 EI 2165-0969 J9 WORKPLACE HEALTH SAF JI Workplace Health Saf. PD JAN PY 2014 VL 62 IS 1 BP 19 EP 26 DI 10.3928/21650799-20131220-04 PG 8 WC Nursing SC Nursing GA AE2KU UT WOS:000333802600004 PM 24571051 ER PT J AU Dorsey, KIA Moritz, ED Notari, EP Schonberger, LB Dodd, RY AF Dorsey, Kern I. A. Moritz, Erin D. Notari, Edward P. Schonberger, Lawrence B. Dodd, Roger Y. TI Survival of blood transfusion recipients identified by a look-back investigation SO BLOOD TRANSFUSION LA English DT Article DE blood transfusion; post-transfusion survival; recipient survival; transfusion recipients; year of transfusion ID LONG-TERM SURVIVAL; CREUTZFELDT-JAKOB-DISEASE; HEPATITIS-C LOOKBACK; SWEDEN; RISK AB Background. Survival of blood transfusion recipients is a critical consideration in assessing the outcomes oftransfusion. Data from the USA on the short- and long-term survival of recipients are limited. Materials and methods. Blood product recipients were identified through a look-back study of Creutzfeldt-Jakob disease. Survival data were obtained from searches of the National Death Index or the Social Security Death Master File. Short- and long-term survival of recipients was analysed through descriptive statistics, Kaplan-Meier survival analysis, and stratified Cox proportional hazard modelling. Results. This study includes data from 575 blood product recipients. One half of the recipients died within the first year of transfusion and the median time to death was 1.1 years. Survival rates at 5, 10, 15, 20, and 25 years after transfusion were 32%, 22%, 15%, 12%, and 9%, respectively. Survival rates varied with age at transfusion and type of component received, but not by gender. Survival after transfusion varied by year of transfusion, with recipients transfused in 1980-1989 having longer post-transfusion survival than those transfused in 2000-2010 (p=0.049). In multivariate models, the type of component transfused, but not the year of transfusion, was a significant predictor of survival among recipients; this effect varied by age. Discussion. We provide an estimate of survival time from a geographically diverse sample of blood product recipients in the USA. Predictors of post-transfusion survival are numerous and complex, and may include year of transfusion and type of component transfused. C1 [Dorsey, Kern I. A.; Moritz, Erin D.; Notari, Edward P.; Dodd, Roger Y.] Amer Red Cross, Jerome H Holland Lab Biomed Sci, Rockville, MD 20855 USA. [Schonberger, Lawrence B.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. RP Dodd, RY (reprint author), Amer Red Cross, Jerome H Holland Lab Biomed Sci, 15601 Crabbs Branch Way, Rockville, MD 20855 USA. EM roger.dodd@redcross.org FU CJD Foundation FX The Authors would like to acknowledge the blood centres and regions that identified and reported both the donors for the CJD look-back investigation and the recipients involved in this study. The Authors are also grateful to the CJD Foundation (Florence Kranitz and her colleagues) for their support in spreading the word about the look-back investigation. Finally, the Authors would like to thank Fatemeh Musavi from the American Red Cross for her SAS programming help. NR 21 TC 1 Z9 1 U1 0 U2 0 PU SIMITI SERVIZI SRL PI MILAN PA VIA DESIDERIO 21, MILAN, 20131, ITALY SN 1723-2007 J9 BLOOD TRANSFUS-ITALY JI Blood Transf. PD JAN PY 2014 VL 12 IS 1 BP 67 EP 72 DI 10.2450/2013.0047-13 PG 6 WC Hematology SC Hematology GA AC1OR UT WOS:000332266400013 PM 24333056 ER PT J AU Jere, KC Esona, MD Ali, YH Peenze, I Roy, S Bowen, MD Saeed, IK Khalafalla, AI Nyaga, MM Mphahlele, J Steele, D Seheri, ML AF Jere, Khuzwayo C. Esona, Mathew D. Ali, Yahia H. Peenze, Ina Roy, Sunando Bowen, Michael D. Saeed, Intisar K. Khalafalla, AbdelMelik I. Nyaga, Martin M. Mphahlele, Jeffrey Steele, Duncan Seheri, Mapaseka L. TI Novel NSP1 genotype characterised in an African camel G8P[11] rotavirus strain SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Camel rotavirus; Africa; Whole genome analysis; Rotavirus genotypes ID GROUP-A ROTAVIRUS; FULL GENOMIC ANALYSIS; MOLECULAR CHARACTERIZATION; INTERSPECIES TRANSMISSION; PROVIDES EVIDENCE; VP6 GENES; IDENTIFICATION; G8; CLASSIFICATION; DS-1-LIKE AB Animal-human interspecies transmission is thought to play a significant role in influencing rotavirus strain diversity in humans. Proving this concept requires a better understanding of the complete genetic constellation of rotaviruses circulating in various animal species. However, very few whole genomes of animal rotaviruses, especially in developing countries, are available. In this study, complete genetic configuration of the first African camel rotavirus strain (RVA/Camel-wt/SDN/MRC-DPRU447/2002/G8P[11]) was assigned a unique G8-P[11]-I2-R2-C2-M2-A18-N2-T6-E2-H3 genotype constellation that has not been reported in other ruminants. It contained a novel NSP1 genotype (genotype A18). The evolutionary dynamics of the genome segments of strain MRC-DPRU447 were rather complex compared to those found in other camelids. Its genome segments 1, 3, 7-10 were closely related (>93% nucleotide identity) to those of human-animal reassortant strains like RVA/Human-tc/ITA/PA169/1988/G6P[14] and RVA/ Human-wt/HUN/Hun5/1997/G6P[14], segments 4, 6 and 11 shared common ancestry (>95% nucleotide identity) with bovine rotaviruses like strains RVA/Cow-wt/CHN/DQ-75/2008/G10P[11] and RVA/Cowwt/ KOR/KJ19-2/XXXX/G6P[7], whereas segment 2 was closely related (94% nucleotide identity) to guanaco rotavirus strain RVA/Guanaco-wt/ARG/Rio_Negro/1998/G8P[1]. Its genetic backbone consisted of DS-1-like, AU-1-like, artiodactyl-like and a novel A18 genotype. This suggests that strain MRC-DPRU447 potentially emerged through multiple reassortment events between several mammalian rotaviruses of at least two genogroups or simply strain MRC-DPRU447 display a unique progenitor genotypes. Close relationship between some of the genome segments of strain MRC-DPRU447 to human rotaviruses suggests previous occurrence of reassortment processes combined with interspecies transmission between humans and camels. The whole genome data for strain MRC-DPRU447 adds to the much needed animal rotavirus data from Africa which is limited at the moment. (C) 2013 Elsevier B.V. All rights reserved. C1 [Jere, Khuzwayo C.; Esona, Mathew D.; Peenze, Ina; Nyaga, Martin M.; Mphahlele, Jeffrey; Steele, Duncan; Seheri, Mapaseka L.] Univ Limpopo, NHLS Dr George Mukhari Tertiary Lab, MRC, Diarrhoeal Pathogens Res Unit,Dept Virol, Pretoria, South Africa. [Esona, Mathew D.; Roy, Sunando; Bowen, Michael D.] CDC, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, NCIRD, Atlanta, GA 30333 USA. [Ali, Yahia H.; Saeed, Intisar K.] Dept Virol, Cent Vet Res Lab, Khartoum, Sudan. [Khalafalla, AbdelMelik I.] Univ Khartoum, Dept Microbiol, Fac Vet Med, Shambat 13314, Khartoum North, Sudan. [Jere, Khuzwayo C.] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Liverpool L69 3BX, Merseyside, England. RP Seheri, ML (reprint author), Univ Limpopo, Dept Virol, POB 173, ZA-0204 Medunsa, South Africa. EM mapaseka.seheri@ul.ac.za OI Khalafalla, Abdelmalik/0000-0001-9156-1361; Jere, Khuzwayo/0000-0003-3376-8529 FU Medical Research Council of South Africa FX We thank Mr. Andrew M. Musyoki and Mr. Lorens L. Maake for critical reading of the manuscript; and Miss. Leah Nemarude for technical support. This work was financially supported by the Medical Research Council of South Africa. NR 34 TC 19 Z9 20 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD JAN PY 2014 VL 21 BP 58 EP 66 DI 10.1016/j.meegid.2013.10.002 PG 9 WC Infectious Diseases SC Infectious Diseases GA AC1RN UT WOS:000332273800006 PM 24184096 ER PT J AU Mijatovic-Rustempasic, S Teel, EN Kerin, TK Hull, JJ Roy, S Weinberg, GA Payne, DC Parashar, UD Gentsch, JR Bowen, MD AF Mijatovic-Rustempasic, Slavica Teel, Elizabeth N. Kerin, Tara K. Hull, Jennifer J. Roy, Sunando Weinberg, Geoffrey A. Payne, Daniel C. Parashar, Umesh D. Gentsch, Jon R. Bowen, Michael D. TI Genetic analysis of G12P[8] rotaviruses detected in the largest US G12 genotype outbreak on record SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus; USA; VP7 protein; VP4 protein; VP8*; Vaccine ID GROUP-A ROTAVIRUS; UNITED-STATES; PHYLOGENETIC ANALYSIS; STRAIN SURVEILLANCE; TRYPSIN ENHANCEMENT; BINDING DOMAIN; GLOBAL SPREAD; CHILDREN; VP4; PROTEIN AB In 2006-07, 77 cases of gastroenteritis in Rochester, NY, USA were associated with rotavirus genotype G12P[8]. Sequence analysis identified a high degree of genetic relatedness among the VP7 and VP4 genes of the Rochester G12P[8] strains and between these strains and currently circulating human G12P[8] strains. Out of 77 samples, two and seven unique nucleotide sequences were identified for VP7 and VP4 genes, respectively. Rochester strain VP7 genes were found to occupy the G12-III lineage and VP4 genes clustered within the P[8]-3 lineage. Six strains contained non-synonymous nucleotide substitutions that produced amino acid changes at 6 sites in the VP8/region of the VP4 gene. Two sites (amino acids 242 and 246) were located in or near a described trypsin cleavage site. Selection analyses identified one positively selected VP7 site (107) and strong purifying selection at 58 sites within the VP7 gene as well as 2 of the 6 variant sites (79 and 218) in VP4. Published by Elsevier B.V. C1 [Mijatovic-Rustempasic, Slavica; Teel, Elizabeth N.; Kerin, Tara K.; Hull, Jennifer J.; Roy, Sunando; Payne, Daniel C.; Parashar, Umesh D.; Gentsch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Weinberg, Geoffrey A.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA. RP Bowen, MD (reprint author), Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, DVD, NCIRD, 1600 Clifton Rd NE,Mailstop G04, Atlanta, GA 30333 USA. EM mkb6@cdc.gov FU Intramural CDC HHS [CC999999] NR 47 TC 14 Z9 15 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD JAN PY 2014 VL 21 BP 214 EP 219 DI 10.1016/j.meegid.2013.11.004 PG 6 WC Infectious Diseases SC Infectious Diseases GA AC1RN UT WOS:000332273800024 PM 24270016 ER PT J AU Vaughan, G Rossi, LMG Forbi, JC de Paula, VS Purdy, MA Xia, GL Khudyakov, YE AF Vaughan, Gilberto Goncalves Rossi, Livia Maria Forbi, Joseph C. de Paula, Vanessa S. Purdy, Michael A. Xia, Guoliang Khudyakov, Yury E. TI Hepatitis A virus: Host interactions, molecular epidemiology and evolution SO INFECTION GENETICS AND EVOLUTION LA English DT Review DE Hepatitis A virus; Molecular epidemiology; Genetic relatedness; Genotype; Molecular evolution; Host factors ID INJECTING DRUG-USERS; DOUBLE-STRANDED-RNA; RIO-DE-JANEIRO; IRES-DEPENDENT TRANSLATION; INNATE ANTIVIRAL RESPONSES; TRACT-BINDING-PROTEIN; ACUTE VIRAL-HEPATITIS; TOLL-LIKE RECEPTOR-3; CHILD-CARE CENTER; NF-KAPPA-B AB Infection with hepatitis A virus (HAV) is the commonest viral cause of liver disease and presents an important public health problem worldwide. Several unique HAV properties and molecular mechanisms of its interaction with host were recently discovered and should aid in clarifying the pathogenesis of hepatitis A. Genetic characterization of HAV strains have resulted in the identification of different genotypes and subtypes, which exhibit a characteristic worldwide distribution. Shifts in HAV endemicity occurring in different parts of the world, introduction of genetically diverse strains from geographically distant regions, genotype displacement observed in some countries and population expansion detected in the last decades of the 20th century using phylogenetic analysis are important factors contributing to the complex dynamics of HAV infections worldwide. Strong selection pressures, some of which, like usage of deoptimized codons, are unique to HAV, limit genetic variability of the virus. Analysis of subgenomic regions has been proven useful for outbreak investigations. However, sharing short sequences among epidemiologically unrelated strains indicates that specific identification of HAV strains for molecular surveillance can be achieved only using whole-genome sequences. Here, we present up-to-date information on the HAV molecular epidemiology and evolution, and highlight the most relevant features of the HAV-host interactions. Published by Elsevier B.V. C1 [Vaughan, Gilberto; Goncalves Rossi, Livia Maria; Forbi, Joseph C.; Purdy, Michael A.; Xia, Guoliang; Khudyakov, Yury E.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [de Paula, Vanessa S.] Fiocruz MS, Inst Oswaldo Cruz, Lab Viral Hepatitis, BR-21045900 Rio De Janeiro, Brazil. RP Vaughan, G (reprint author), Ctr Dis Control & Prevent, Mol Epidemiol & Bioinformat Lab, Div Viral Hepatitis, 1600 Clifton Rd,M-S A-33, Atlanta, GA 30333 USA. EM GVaughan@cdc.gov NR 240 TC 23 Z9 25 U1 3 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD JAN PY 2014 VL 21 BP 227 EP 243 DI 10.1016/j.meegid.2013.10.023 PG 17 WC Infectious Diseases SC Infectious Diseases GA AC1RN UT WOS:000332273800026 PM 24200587 ER PT J AU Cui, AL Zhu, Z Chen, M Zheng, HY Liu, L Wang, Y Ma, Y Wang, CY Fang, XQ Li, P Guan, RH Wang, S Zhou, JH Zheng, L Gao, H Ding, ZR Li, LQ Bo, F Sun, ZD Zhang, ZY Feng, DX He, JL Chen, H Jin, L Rota, PA Xu, WB AF Cui, Aili Zhu, Zhen Chen, Meng Zheng, Huanying Liu, Leng Wang, Yan Ma, Yan Wang, Changyin Fang, Xueqiang Li, Ping Guan, Ronghui Wang, Shuang Zhou, Jianhui Zheng, Lei Gao, Hui Ding, Zhengrong Li, Liqun Bo, Fang Sun, Zhaodan Zhang, Zhenying Feng, Daxing He, Jilan Chen, Hui Jin, Li Rota, Paul A. Xu, Wenbo TI Epidemiologic and genetic characteristics of mumps viruses isolated in China from 1995 to 2010 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Mumps virus; Epidemiology; Genetic characteristics ID SH GENE; GENOTYPES; SEQUENCE; STRAINS; JAPAN AB The epidemiologic and genetic characteristics of mumps viruses detected in China from 1995 to 2010 were analyzed in this study. Mumps remains endemic in China with a high overall incidence rate. The incidence of mumps in Western China was higher than that in other regions of the country. Each year, most of mumps cases occurred between April and July, but a small peak also occurred in November and December. Mumps cases primarily affected the under 15 year old age group. Virologic data demonstrated that genotype F was the predominant circulating genotype throughout China for at least 15 years and no other genotype was detected between 1995 and 2010. Analysis of sequence data from the small hydrophobic (SH) gene indicated that multiple transmission chains of genotype F were found in various provinces of China, with no apparent chronologic and geographic restriction. This is the first report describing the epidemiology of mumps and genetic characterization of mumps viruses at the national level in China. (C) 2013 Elsevier B. V. All rights reserved. C1 [Cui, Aili; Zhu, Zhen; Xu, Wenbo] China Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China. [Chen, Meng] Beijing Prov Ctr Dis Control & Prevent, Beijing 100013, Peoples R China. [Zheng, Huanying; Liu, Leng] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China. [Wang, Yan; Ma, Yan] Liaoning Prov Ctr Dis Control & Prevent, Shenyang 110005, Peoples R China. [Wang, Changyin; Fang, Xueqiang] Shandong Prov Ctr Dis Control & Prevent, Jinan 250014, Peoples R China. [Li, Ping; Guan, Ronghui] Shannxi Prov Ctr Dis Control & Prevent, Xian 710054, Peoples R China. [Wang, Shuang; Zhou, Jianhui] Jilin Prov Ctr Dis Control & Prevent, Changchun 130062, Peoples R China. [Zheng, Lei; Gao, Hui] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan 030012, Peoples R China. [Ding, Zhengrong; Li, Liqun] Yunnan Prov Ctr Dis Control & Prevent, Kunming 650022, Peoples R China. [Bo, Fang; Sun, Zhaodan] Heilongjiang Prov Ctr Dis Control & Prevent, Haerbin 150030, Peoples R China. [Zhang, Zhenying; Feng, Daxing] Henan Prov Ctr Dis Control & Prevent, Zhengzhou 450016, Peoples R China. [He, Jilan] Sichuan Prov Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China. [Chen, Hui] Ningxia Prov Ctr Dis Control & Prevent, Yinchuan 750004, Peoples R China. [Jin, Li] Publ Hlth England, Virus Reference Dept, London NW9 5EQ, England. [Rota, Paul A.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Xu, WB (reprint author), 155 Chang Bai Rd, Beijing 102206, Peoples R China. EM wenbo_xu1@aliyun.com FU National Natural Science Foundation of China [81102170]; National Infectious Disease Surveillance Program of the Ministry of Science and Technology of the People's Republic of China [2012ZX10004201-003, 2013ZX10004202] FX This work was partially supported by the National Natural Science Foundation of China (Project No. 81102170), the National Infectious Disease Surveillance Program of the Ministry of Science and Technology of the People's Republic of China (2012ZX10004201-003 and 2013ZX10004202). NR 25 TC 6 Z9 6 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD JAN PY 2014 VL 21 BP 384 EP 390 DI 10.1016/j.meegid.2013.12.005 PG 7 WC Infectious Diseases SC Infectious Diseases GA AC1RN UT WOS:000332273800044 PM 24355245 ER PT J AU Onufrak, SJ Park, S Sharkey, JR Sherry, B AF Onufrak, Stephen J. Park, Sohyun Sharkey, Joseph R. Sherry, Bettylou TI The relationship of perceptions of tap water safety with intake of sugar- sweetened beverages and plain water among US adults SO PUBLIC HEALTH NUTRITION LA English DT Article DE Drinking water; Beverages; Perceptions ID BOTTLED WATER; MINORITY CHILDREN; BODY-WEIGHT; CONSUMPTION; HEALTH; ADOLESCENTS; LATINO AB Objective Research is limited on whether mistrust of tap water discourages plain water intake and leads to a greater intake of sugar-sweetened beverages (SSB). The objective of the present study was to examine demographic differences in perceptions of tap water safety and determine if these perceptions are associated with intake of SSB and plain water. Design The study examined perceptions of tap water safety and their cross-sectional association with intake of SSB and plain water. Racial/ethnic differences in the associations of tap water perceptions with SSB and plain water intake were also examined. Setting Nationally weighted data from the 2010 HealthStyles Survey (n 4184). Subjects US adults aged 18 years. Results Overall, 130 % of participants disagreed that their local tap water was safe to drink and 264 % of participants agreed that bottled water was safer than tap water. Both mistrust of tap water safety and favouring bottled water differed by region, age, race/ethnicity, income and education. The associations of tap water mistrust with intake of SSB and plain water were modified by race/ethnicity (P < 005). Non-white racial/ethnic groups who disagreed that their local tap water was safe to drink were more likely to report low intake of plain water. The odds of consuming 1 SSB/d among Hispanics who mistrusted their local tap water was twice that of Hispanics who did not (OR = 20; 95 % CI 12, 33). Conclusions Public health efforts to promote healthy beverages should recognize the potential impact of tap water perceptions on water and SSB intake among minority populations. C1 [Onufrak, Stephen J.; Park, Sohyun; Sherry, Bettylou] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Obes Prevent & Control Branch, Atlanta, GA 30341 USA. [Sharkey, Joseph R.] Texas A&M Univ, Sch Rural Publ Hlth, College Stn, TX USA. RP Onufrak, SJ (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Obes Prevent & Control Branch, 4770 Buford Highway NE,MS K-26, Atlanta, GA 30341 USA. EM seo5@cdc.gov FU Intramural CDC HHS [CC999999] NR 21 TC 8 Z9 8 U1 2 U2 9 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1368-9800 EI 1475-2727 J9 PUBLIC HEALTH NUTR JI Public Health Nutr. PD JAN PY 2014 VL 17 IS 1 BP 179 EP 185 DI 10.1017/S1368980012004600 PG 7 WC Public, Environmental & Occupational Health; Nutrition & Dietetics SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA AC2YX UT WOS:000332383300022 PM 23098620 ER PT J AU Boland, TA McGuone, D Jindal, J Rocha, M Cumming, M Rupprecht, CE Barbosa, TFS Oliveira, RD Chu, CJ Cole, AJ Kotait, I Kuzmina, NA Yager, PA Kuzmin, IV Hedley-Whyte, ET Brown, CM Rosenthal, ES AF Boland, Torrey A. McGuone, Declan Jindal, Jenelle Rocha, Marcelo Cumming, Melissa Rupprecht, Charles E. Souza Barbosa, Taciana Fernandes Oliveira, Rafael de Novaes Chu, Catherine J. Cole, Andrew J. Kotait, Ivanete Kuzmina, Natalia A. Yager, Pamela A. Kuzmin, Ivan V. Hedley-Whyte, E. Tessa Brown, Catherine M. Rosenthal, Eric S. TI Phylogenetic and Epidemiologic Evidence of Multiyear Incubation in Human Rabies SO ANNALS OF NEUROLOGY LA English DT Article ID UNITED-STATES AB Eight years after emigrating from Brazil, an otherwise healthy man developed rabies. An exposure prior to immigration was reported. Genetic analysis revealed a canine rabies virus variant found only in the patient's home country, and the patient had not traveled internationally since immigrating to the United States. We describe how epidemiological, phylogenetic, and viral sequencing data provided confirmation that rabies encephalomyelitis may present after a long, multiyear incubation period, a consideration that previously has been hypothesized without the ability to exclude a more recent exposure. Accordingly, rabies should be considered in the diagnosis of any acute encephalitis, myelitis, or encephalomyelitis. C1 [Boland, Torrey A.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. [McGuone, Declan; Hedley-Whyte, E. Tessa] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol,Dept Pathol, Boston, MA USA. [Jindal, Jenelle; Rocha, Marcelo; Chu, Catherine J.; Cole, Andrew J.; Rosenthal, Eric S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA. [Cumming, Melissa; Brown, Catherine M.] Hinton State Lab, Massachusetts Dept Publ Hlth, Jamaica Plain, MA USA. [Rupprecht, Charles E.] Global Alliance Rabies Control, Manhattan, KS USA. [Souza Barbosa, Taciana Fernandes] Evandro Chagas Inst, Para, Brazil. [Oliveira, Rafael de Novaes; Kotait, Ivanete] Inst Pasteur, Sao Paulo, Brazil. [Kuzmina, Natalia A.; Yager, Pamela A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kuzmin, Ivan V.] Aravan LLC, Lilburn, GA USA. RP Boland, TA (reprint author), Rush Univ, Med Ctr, Dept Neurol Sci, 1725 W Harrison St,Suite 1106, Chicago, IL 60612 USA. EM torrey_boland@rush.edu OI Rosenthal, Eric/0000-0003-3900-356X FU NIH National Institute of Neurological Diseases and Stroke FX A.J.C.: consultancy, Clarus Ventures, Concert Pharmaceuticals, Sage Pharmaceuticals, Eisai Pharmaceuticals; grants/grants pending, NIH National Institute of Neurological Diseases and Stroke. P. A. Y.: royalties, EMD Millipore (Chemicon International). NR 14 TC 2 Z9 2 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0364-5134 EI 1531-8249 J9 ANN NEUROL JI Ann. Neurol. PD JAN PY 2014 VL 75 IS 1 BP 155 EP 160 DI 10.1002/ana.24016 PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AA3WQ UT WOS:000331026300017 PM 24038455 ER PT J AU Chiu, CH Noe, RS Martin, JP Wolkin, AF Vagi, SJ AF Chiu, Cindy H. Noe, Rebecca S. Martin, John Paul Wolkin, Amy F. Vagi, Sara J. TI The Use of Community Assessment for Public Health Emergency Response to Evaluate NWS Warnings SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article C1 [Chiu, Cindy H.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA 30341 USA. [Noe, Rebecca S.; Vagi, Sara J.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Martin, John Paul] NOAA, US Dept Commerce, NWS Weather Forecast Off, Bismarck, ND USA. [Wolkin, Amy F.] Ctr Dis Control & Prevent, Disaster Epidemiol & Response Team, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Chiu, CH (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, 4770 Buford Hwy,Mississippi F-60, Atlanta, GA 30341 USA. EM cchiu@cdc.gov OI Chiu, Cindy H/0000-0003-2226-2776 FU Intramural CDC HHS [CC999999] NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD JAN PY 2014 VL 95 IS 1 BP 18 EP 21 DI 10.1175/BAMS-D-12-00123.1 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AB8NL UT WOS:000332047200005 PM 27293241 ER PT J AU Welcome, DE Dong, RG Xu, XYS Warren, C McDowell, TW AF Welcome, Daniel E. Dong, Ren G. Xu, Xueyan S. Warren, Christopher McDowell, Thomas W. TI The effects of vibration-reducing gloves on finger vibration SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Finger vibration; Anti-vibration glove; Vibration-reducing glove; Hand-arm vibration; Hand-transmitted vibration ID NONCONTACT MEASUREMENT; ISOLATION PERFORMANCE; ANTIVIBRATION GLOVES; MECHANICAL IMPEDANCE; HAND-VIBRATION; ARM; TRANSMISSIBILITY; HAZARDS; HAMMER AB Vibration-reducing (VR) gloves have been used to reduce the hand-transmitted vibration exposures from machines and powered hand tools but their effectiveness remains unclear, especially for finger protection. The objectives of this study are to determine whether VR gloves can attenuate the vibration transmitted to the fingers and to enhance the understanding of the mechanisms of how these gloves work. Seven adult male subjects participated in the experiment. The fixed factors evaluated include hand force (four levels), glove condition (gel-filled, air bladder, no gloves), and location of the finger vibration measurement: A 3-D laser vibrometer was used to measure the vibrations on the fingers with and without wearing a glove on a 3-D hand-arm vibration test system. This study finds that the effect of VR gloves on the finger vibration depends on not only the gloves but also their influence on the distribution of the finger contact stiffness and the grip effort. As a result, the gloves increase the vibration in the fingertip area but marginally reduce the vibration in the proximal area at some frequencies below 100 Hz. On average, the gloves reduce the vibration of the entire fingers by less than 3% at frequencies below 80 Hz but increase at frequencies from 80 to 400 Hz. At higher frequencies, the gel-filled glove is more effective at reducing the finger vibration than the air bladder-filled glove. The implications of these findings are discussed. Relevance to industry: Prolonged, intensive exposure to hand-transmitted vibration can cause hand-arm vibration syndrome. Vibration-reducing gloves have been used as an alternative approach to reduce the vibration exposure. However, their effectiveness for reducing finger-transmitted vibrations remains unclear. This study enhanced the understanding of the glove effects on finger vibration and provided useful information on the effectiveness of typical VR gloves at reducing the vibration transmitted to the fingers. The new results and knowledge can be used to help select appropriate gloves for the operations of powered hand tools, to help perform risk assessment of the vibration exposure, and to help design better VR gloves. Published by Elsevier B.V. C1 [Welcome, Daniel E.; Dong, Ren G.; Xu, Xueyan S.; Warren, Christopher; McDowell, Thomas W.] NIOSH, Engn & Control Technol Branch, HELD, CDC, Morgantown, WV 26505 USA. RP Dong, RG (reprint author), NIOSH, Engn & Control Technol Branch, HELD, CDC, MS L-2027,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM rkd6@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 FU Intramural CDC HHS [CC999999] NR 36 TC 11 Z9 12 U1 1 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 EI 1872-8219 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JAN PY 2014 VL 44 IS 1 BP 45 EP 59 DI 10.1016/j.ergon.2013.10.003 PG 15 WC Engineering, Industrial; Ergonomics SC Engineering GA AC2SN UT WOS:000332354400007 PM 26543297 ER PT J AU Sabogal, RI Medlin, E Aquino, G Gelting, RJ AF Sabogal, Raquel I. Medlin, Elizabeth Aquino, Gonzalo Gelting, Richard J. TI Sustainability of water, sanitation and hygiene interventions in Central America SO JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT LA English DT Article DE Central America; evaluation; hygiene promotion; sanitation; sustainability; water AB The American Red Cross and U. S. Centers for Disease Control and Prevention collaborated on a sustainability evaluation of post-hurricane water, sanitation and hygiene (WASH) interventions in Central America. In 2006 and 2009, we revisited six study areas in rural El Salvador, Guatemala, Honduras and Nicaragua to assess sustainability of WASH interventions finalized in 2002, after 1998's Hurricane Mitch. We used surveys to collect data, calculate indicators and identify factors that influence sustainability. Regional sustainability indicator results showed there was a statistically significant decline in access to water. The presence of sanitation facilities had not changed since the beginning of the project; however, maintenance and use of latrines declined but continued to meet the goal of 75% use after 7 years. The hygiene indicator, hand washing, initially declined and then increased. Declines in water access were due to operational problems related to storm events and population changes. Sanitation facilities were still present and sometimes used even though they reached or surpassed their original design life. Changes in hygiene practices appeared related to ongoing hygiene promotion from outside organizations. These results provide useful input for making WASH programs more sustainable and informing future, more in-depth research into factors influencing sustainability. C1 [Sabogal, Raquel I.; Medlin, Elizabeth; Gelting, Richard J.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Chamblee, GA 30341 USA. [Aquino, Gonzalo] Amer Red Cross, Water & Sanitat Delegate Latin Amer & Caribbean R, Qual & Learning Unit, Panama City, Panama. RP Sabogal, RI (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, 4770 Buford Highway NE, Chamblee, GA 30341 USA. EM rsabogal@cdc.gov FU American Red Cross, Red Cross National Societies water and sanitation delegates FX The authors would like to thank the American Red Cross, Red Cross National Societies water and sanitation delegates, and all community members who participated in our study. Their support ensured our success with this study. American Red Cross (Sergio Denegri, Mark Toy) and Red Cross National Societies (El Salvador-Mirna Zelaya, Salvador Molina, Adan Rivas; Guatemala-Maria Teresa Estrada, Adolfo Saguil; Honduras-Joel Duron, Jorge Pinel; Nicaragua-Carmen Maria Garcia Bucardo, David Maxwell, Ramona Caceres). We would also like to thank the additional CDC investigators who participated in past data collections (Lana Corrales MPH, Victoria Cuellar MPH, Kristin Delea MPH, Jane Horton MPH, Carolyn Monteilh PhD). NR 22 TC 1 Z9 1 U1 2 U2 18 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 2043-9083 J9 J WATER SANIT HYG DE JI J. Wate Sanit. Hyg. Dev. PY 2014 VL 4 IS 1 BP 89 EP 99 DI 10.2166/washdev.2013.130 PG 11 WC Water Resources SC Water Resources GA AB8XH UT WOS:000332072800010 PM 26413262 ER PT J AU Hubbard, B Lockhart, G Gelting, RJ Bertrand, F AF Hubbard, Brian Lockhart, Gabriella Gelting, Richard J. Bertrand, Fabienne TI Development of Haiti's rural water, sanitation and hygiene workforce SO JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT LA English DT Article DE cholera; Haiti; sanitation and hygiene; water quality; water; workforce development AB In 2009 the Haitian Directorate of Potable Water and Sanitation (DINEPA) identified an inadequately trained and under-staffed rural workforce as one of their main institutional challenges. Plans to address this challenge were impacted by the devastating earthquake of January 12, 2010 and the cholera outbreak of October 2010, both of which further complicated Haiti's already poor water and sanitation conditions. Recognizing the importance of DINEPA's institutional priorities, donor and technical assistance groups provided needed support to improve the country's conditions and build the rural water and sanitation workforce. This report describes how DINEPA and the US Centers for Disease Control and Prevention (CDC) collaborated to design and implement a training program for 264 potable water and sanitation technicians for rural areas. The paper also describes the initial field activities of the newly trained technicians and the immediate impact of their work in the rural water, sanitation and hygiene sector. C1 [Hubbard, Brian] US Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Natl Ctr Environm Hlth, Dept Hlth & Human Serv, Atlanta, GA 30341 USA. [Lockhart, Gabriella] US Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Natl Ctr Environm Hlth, Dept Hlth & Human Serv, Brookline, MA 02445 USA. [Gelting, Richard J.] US Ctr Dis Control & Prevent, Hlth Syst Reconstruct Team, Emergency Response & Recovery Branch, Div Global Hlth Protect,Ctr Global Hlth,Dept Hlth, Atlanta, GA 30329 USA. [Bertrand, Fabienne] Natl Directorate Potable Water & Sanitat, Petion Ville, Haiti. RP Hubbard, B (reprint author), US Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Natl Ctr Environm Hlth, Dept Hlth & Human Serv, 4770 Buford Highway,MS F-58, Atlanta, GA 30341 USA. EM bnh5@cdc.gov FU Inter-American Development Bank (IADB); World Bank FX The authors would like to acknowledge the contributions of the Inter-American Development Bank (IADB), and the World Bank for their financial and technical support of the TEPAC program. Additionally, the authors would like to thank Dr Thomas Handzel for his leadership and direction of WASH activities in Haiti, and Kitty Middleton, Molly Patrick and Martin Fogl for their technical, management and communication support with stakeholders in the water and sanitation sector in Haiti. NR 6 TC 1 Z9 1 U1 7 U2 29 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 2043-9083 J9 J WATER SANIT HYG DE JI J. Wate Sanit. Hyg. Dev. PY 2014 VL 4 IS 1 BP 159 EP 163 DI 10.2166/washdev.2013.089 PG 5 WC Water Resources SC Water Resources GA AB8XH UT WOS:000332072800017 ER PT J AU Lockhart, G Oswald, WE Hubbard, B Medlin, E Gelting, RJ AF Lockhart, Gabriella Oswald, William E. Hubbard, Brian Medlin, Elizabeth Gelting, Richard J. TI Development of indicators for measuring outcomes of water safety plans SO JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT LA English DT Article DE drinking water; evaluation; indicators; outcomes; water safety plans ID FRAMEWORK AB Water safety plans (WSPs) are endorsed by the World Health Organization as the most effective method of protecting a water supply. With the increase in WSPs worldwide, several valuable resources have been developed to assist practitioners in the implementation of WSPs, yet there is still a need for a practical and standardized method of evaluating WSP effectiveness. In 2012, the Centers for Disease Control and Prevention (CDC) published a conceptual framework for the evaluation of WSPs, presenting four key outcomes of the WSP process: institutional, operational, financial and policy change. In this paper, we seek to operationalize this conceptual framework by providing a set of simple and practical indicators for assessing WSP outcomes. Using CDC's WSP framework as a foundation and incorporating various existing performance monitoring indicators for water utilities, we developed a set of approximately 25 indicators of institutional, operational, financial and policy change within the WSP context. These outcome indicators hold great potential for the continued implementation and expansion of WSPs worldwide. Having a defined framework for evaluating a WSP's effectiveness, along with a set of measurable indicators by which to carry out that evaluation, will help implementers assess key WSP outcomes internally, as well as benchmark their progress against other WSPs in their region and globally. C1 [Lockhart, Gabriella; Oswald, William E.; Hubbard, Brian; Medlin, Elizabeth; Gelting, Richard J.] US Ctr Dis Control & Prevent, Water Sanitat & Hyg Team, Environm Hlth Serv Branch, Natl Ctr Environm Hlth,Dept Hlth & Human Serv, Atlanta, GA USA. RP Gelting, RJ (reprint author), 4770 Buford Highway NE,MS F-57, Atlanta, GA 30341 USA. EM rgelting@cdc.gov FU Intramural CDC HHS [CC999999] NR 16 TC 2 Z9 2 U1 0 U2 6 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 2043-9083 J9 J WATER SANIT HYG DE JI J. Wate Sanit. Hyg. Dev. PY 2014 VL 4 IS 1 BP 171 EP 181 DI 10.2166/washdev.2013.159 PG 11 WC Water Resources SC Water Resources GA AB8XH UT WOS:000332072800019 PM 26361540 ER PT J AU Marienau, KJ Cramer, EH Coleman, MS Marano, N Cetron, MS AF Marienau, Karen J. Cramer, Elaine H. Coleman, Margaret S. Marano, Nina Cetron, Martin S. TI Flight related tuberculosis contact investigations in the United States: Comparative risk and economic analysis of alternate protocols SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Tuberculosis; TB; Air travel; Contact investigation; Transmission risk; Cost-benefit analysis ID MYCOBACTERIUM-TUBERCULOSIS; AIR-TRAVEL; INFECTIOUS TUBERCULOSIS; TRANSMISSION; AIRPLANE; EXPOSURE; HEALTH AB Background: In-flight transmission risk of Mycobacterium tuberculosis is not well defined, although studies suggest it is low. The impact of flight-related tuberculosis (TB) contact investigations (TBCIs) on TB prevention and control is not well established, and they compete for resources with activities with established benefits. We sought to determine the risks and cost benefits of using more restrictive criteria in comparison to the Centers for Disease Control and Prevention (CDC) 2008 protocol for TBCIs. Methods: The risk-benefits of a modified CDC protocol were analyzed in comparison to the 2008 CDC protocol using data from flight-related TBCIs conducted in the United States from 2007 through 2009. We predicted the numbers and characteristics of case-travelers that would be identified using each protocol's criteria, and results of the associated passenger-contacts' TB screening tests. The economic analysis compared the costs of TBCIs to avoided costs of TB treatment and mortality using a Return on Investment model. Results: The estimated in-flight transmission risk using a modified CDC protocol was 1.4%-19% versus 1.1%-24% for the 2008 protocol. Numbers of TBCIs and immediate costs to health departments were reduced by half. Long-term cost benefits were comparable. Conclusions: CDC's modified protocol appears to be a feasible alternative that will conserve public health resources without jeopardizing the public's health. Published by Elsevier Ltd. C1 [Marienau, Karen J.; Coleman, Margaret S.; Marano, Nina; Cetron, Martin S.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot, Div Global Migrat & Quarantine, Atlanta, GA USA. [Cramer, Elaine H.] SRA Int, Global Hlth Sect, Atlanta, GA USA. RP Marienau, KJ (reprint author), Suite 2168,7150 Humphrey Dr, Minneapolis, MN 55450 USA. EM marienauk@yahoo.com FU National TB Controllers Association FX Many people, agencies, and organizations collaborated to conduct the TB contact investigations from which data were drawn for our analyses. We express our gratitude to the numerous state and local TB program staff; the many airlines; our Customs and Border Protection partners; and DGMQ staff, including Quarantine Station staff from across the United States, as well as Chris Schembri and Krista Kornylo. Without their contributions our analyses and subsequent policy change would not have been possible. We also want to thank our colleagues in the CDC Division of TB Elimination, Thomas Navin and Suzanne Marks, and the National TB Controllers Association for their consultation and support. NR 37 TC 3 Z9 3 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN-FEB PY 2014 VL 12 IS 1 BP 54 EP 62 DI 10.1016/j.tmaid.2013.09.007 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AC0OA UT WOS:000332193400009 PM 24206902 ER PT J AU Coleman, MS Marienau, KJ Marano, N Marks, SM Cetron, MS AF Coleman, Margaret S. Marienau, Karen J. Marano, Nina Marks, Suzanne M. Cetron, Martin S. TI Economics of United States tuberculosis airline contact investigation policies: A return on investment analysis SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Tuberculosis; Return on investment; Contact tracing ID INFECTION; COSTS; US AB Background: In 2011, the Centers for Disease Control and Prevention modified its 2008 protocol for flight-related tuberculosis contact investigation initiation. The 2011 Modified protocol was implemented and replaced the 2008 CDC protocol based on comparative epidemiologic and economic analyses; this publication reports the economic analysis results. Methods: A return on investment model compared relative changes in tuberculosis disease treatment costs resulting from expenditures on tuberculosis contact investigations and latent tuberculosis infection treatment for the 2008 CDC and Modified protocols. Results: At moderate/high rates of latent tuberculosis infection and tuberculosis disease, positive returns on investment indicated each $1.00 spent on tuberculosis contact investigations and latent tuberculosis treatment resulted in more than $1.00 of savings from reduced tuberculosis disease treatment costs. Low rates of latent tuberculosis infection and tuberculosis disease resulted in negative returns on investment, indicating economic losses from tuberculosis disease treatment costs. There were smaller economic losses at low latent tuberculosis infection and tuberculosis disease rates with the Modified protocol in comparison to the 2008 CDC protocol, while both identified comparable numbers of persons at risk for tuberculosis. Conclusion: The Modified protocol for conducting flight-related tuberculosis contact investigations represents a better use of resources and protects public health. Published by Elsevier Ltd. C1 [Coleman, Margaret S.; Marienau, Karen J.; Marano, Nina; Cetron, Martin S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Marks, Suzanne M.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. RP Coleman, MS (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, 1600 Clifton Rd,Stop E-03, Atlanta, GA 30333 USA. EM mcoleman@cdc.gov NR 29 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN-FEB PY 2014 VL 12 IS 1 BP 63 EP 71 DI 10.1016/j.tmaid.2013.10.016 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AC0OA UT WOS:000332193400010 PM 24262643 ER PT J AU Leeman, J Teal, R Jernigan, J Reed, JH Farris, R Ammerman, A AF Leeman, Jennifer Teal, Randall Jernigan, Jan Reed, Jenica Huddleston Farris, Rosanne Ammerman, Alice TI What Evidence and Support Do State-Level Public Health Practitioners Need to Address Obesity Prevention SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article DE Obesity Prevention; Evidence-Based Practice; Public Health; Prevention Research. Manuscript format: research; Research purpose: descriptive; Study design: qualitative and quantitative survey; Outcome measure: cognitive; Setting: state/national; Health focus: fitness/physical activity; nutrition; Strategy: policy; built environment; Target population: all; Target population circumstances: all ID PHYSICAL-ACTIVITY; DISSEMINATION; KNOWLEDGE; SETTINGS; GAP AB Purpose. Obesity has reached epidemic proportions. Public health practitioners are distinctly positioned to promote the environmental changes essential to addressing obesity. The Centers for Disease Control and Prevention (CDC) and other entities provide evidence and technical assistance to support this work, yet little is known about how practitioners use evidence and support as they intervene to prevent obesity. The study's purpose was to describe how practitioners and CDC project officers characterized the obesity prevention task, where practitioners accessed support and evidence, and what approaches to support and evidence they found most useful. Approach or Design. Mixed-methods, cross-sectional interviews, and survey. Setting. State-level public health obesity prevention programs. Participants. Public health practitioners and CDC project officers. Method. We conducted 10 in-depth interviews with public health practitioners (n = 7) and project officers (n = 3) followed by an online survey completed by 62 practitioners (50% response rate). We applied content analysis to interview data and descriptive statistics to survey data. Results. Practitioners characterized obesity prevention as uncertain and complex, involving interdependence among actors, multiple levels of activity, an excess of information, and a paucity of evidence. Survey findings provide further detail on the types of evidence and support practitioners used and valued. Conclusion. We recommend approaches to tailoring evidence and support to the needs of practitioners working on obesity prevention and other complex health problems. C1 [Leeman, Jennifer] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27510 USA. [Teal, Randall] Univ N Carolina, Cecil G Sheps Ctr Hlth Serv Res, Chapel Hill, NC 27510 USA. [Jernigan, Jan] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Reed, Jenica Huddleston] Deloitte Consulting LLP, Sacramento, CA USA. [Farris, Rosanne] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ammerman, Alice] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27510 USA. [Ammerman, Alice] Univ N Carolina, Ctr Hlth Promot & Dis Prevent, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27510 USA. RP Leeman, J (reprint author), Univ N Carolina, Sch Nursing, Chapel Hill, NC 27510 USA. EM jleeman@email.unc.edu FU AHRQ HHS [K12 HS019468]; NIDDK NIH HHS [P30 DK093002] NR 27 TC 7 Z9 7 U1 0 U2 9 PU AMER JOURNAL HEALTH PROMOTION INC PI TROY PA PO BOX 1254, TROY, MI 48099-1254 USA SN 0890-1171 EI 2168-6602 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD JAN-FEB PY 2014 VL 28 IS 3 BP 189 EP 196 DI 10.4278/ajhp.120518-QUAL-266 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AB6JS UT WOS:000331894900016 PM 23621811 ER PT J AU Ioannidis, JPA Zhou, Y Chang, CQ Schully, SD Khoury, MJ Freedman, AN AF Ioannidis, J. P. A. Zhou, Y. Chang, C. Q. Schully, S. D. Khoury, M. J. Freedman, A. N. TI Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses SO ANNALS OF ONCOLOGY LA English DT Review DE cancer; meta-analysis; pharmacoepidemiology; randomized trials; review ID RANDOMIZED CONTROLLED-TRIALS; CONVERTING-ENZYME-INHIBITORS; NECROSIS-FACTOR THERAPY; CLINICAL-TRIALS; RHEUMATOID-ARTHRITIS; CARDIOVASCULAR-DISEASE; COLORECTAL-CANCER; STATIN THERAPY; PANCREATIC-CANCER; LDL CHOLESTEROL AB Several commonly used medications have been associated with increased cancer risk in the literature. Here, we evaluated the strength and consistency of these claims in published meta-analyses. We carried out an umbrella review of 74 meta-analysis articles addressing the association of commonly used medications (antidiabetics, antihyperlipidemics, antihypertensives, antirheumatics, drugs for osteoporosis, and others) with cancer risk where at least one meta-analysis in the medication class included some data from randomized trials. Overall, 51 articles found no statistically significant differences, 13 found some decreased cancer risk, and 11 found some increased risk (one reported both increased and decreased risks). The 11 meta-analyses that found some increased risks reported 16 increased risk estimates, of which 5 pertained to overall cancer and 11 to site-specific cancer. Six of the 16 estimates were derived from randomized trials and 10 from observational data. Estimates of increased risk were strongly inversely correlated with the amount of evidence (number of cancer cases) (Spearman's correlation coefficient = -0.77, P < 0.001). In 4 of the 16 topics, another meta-analysis existed that was larger (n = 2) or included better controlled data (n = 2) and in all 4 cases there was no statistically significantly increased risk of malignancy. No medication or class had substantial and consistent evidence for increased risk of malignancy. However, for most medications we cannot exclude small risks or risks in population subsets. Such risks are unlikely to be possible to document robustly unless very large, collaborative studies with standardized analyses and no selective reporting are carried out. C1 [Ioannidis, J. P. A.] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Dept Med, Stanford, CA 94305 USA. [Ioannidis, J. P. A.] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Dept Hlth Res & Policy, Stanford, CA 94305 USA. [Ioannidis, J. P. A.] Stanford Univ, Sch Humanities & Sci, Dept Stat, Stanford, CA 94305 USA. [Zhou, Y.] Georgetown Univ, Canc Control Program, Lombardi Comprehens Canc Ctr, Washington, DC USA. [Chang, C. Q.; Schully, S. D.; Khoury, M. J.; Freedman, A. N.] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Khoury, M. J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. RP Ioannidis, JPA (reprint author), Stanford Univ, Sch Med, Stanford Prevent Res Ctr, 1265 Welch Rd,MSOB X306, Stanford, CA 94305 USA. EM jioannid@stanford.edu NR 88 TC 10 Z9 10 U1 0 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 EI 1569-8041 J9 ANN ONCOL JI Ann. Oncol. PD JAN PY 2014 VL 25 IS 1 BP 16 EP 23 DI 10.1093/annonc/mdt372 PG 8 WC Oncology SC Oncology GA AA7HR UT WOS:000331268800004 PM 24310915 ER PT J AU Will, JC Loustalot, F Hong, YL AF Will, Julie C. Loustalot, Fleetwood Hong, Yuling TI National Trends in Visits to Physician Offices and Outpatient Clinics for Angina 1995 to 2010 SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES LA English DT Article DE ambulatory care; epidemiology; health services research; office visits ID UNITED-STATES; CARDIOVASCULAR-DISEASE; CHEST-PAIN; CORONARY; GUIDELINES; UPDATE; DISPARITIES; PREVENTION; PREVALENCE AB Background We asked whether visits to physician offices and hospital outpatient clinics for angina have changed over time and whether more frequent use of certain diagnostic techniques or referrals in this setting may account for such changes. Methods and Results We combined data from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey to study visits to physician offices and outpatient departments. We calculated both crude and standardized rates for these visits using a modified version of technical specifications published by the Agency for Healthcare Research and Quality. In 1995 to 1998, there were on average 3.6 million office/clinic visits each year for angina among adults in the United States. By 2007 to 2010, this had declined to 2.3 million visits each year. Angina visit rates per 100 000 declined significantly (P<0.05), with the greatest decline from 1995 through 1998 to 2003 through 2007. Coronary atherosclerotic disease diagnoses also declined after 2002. Both stress testing and referring patients out for care doubled during some study periods. Conclusions Office and clinic visits for angina have declined over time. This trend parallels findings for both preventable hospitalization and emergency room visits for angina. Previous research's decline in angina hospitalizations is not likely attributable to decreased referrals to hospital and emergency rooms for diagnosis and management. Although changes in International Classification of Diseases, Ninth Revision, Clinical Modification coding guidelines may explain some of the decline in angina and coronary atherosclerotic disease visits, it seems that other factors such as improved treatment or prevention may have played an additional role. C1 [Will, Julie C.; Loustalot, Fleetwood; Hong, Yuling] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Will, JC (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,Mailstop F-72, Atlanta, GA 30341 USA. EM jxw6@cdc.gov FU Intramural CDC HHS [CC999999] NR 26 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1941-7705 EI 1941-7713 J9 CIRC-CARDIOVASC QUAL JI Circ.-Cardiovasc. Qual. Outcomes PD JAN PY 2014 VL 7 IS 1 BP 110 EP 117 DI 10.1161/CIRCOUTCOMES.113.000450 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AA4MY UT WOS:000331071200016 PM 24425707 ER PT J AU See, I Shehab, N Kegler, SR Laskar, SR Budnitz, DS AF See, Isaac Shehab, Nadine Kegler, Scott R. Laskar, S. Raja Budnitz, Daniel S. TI Emergency Department Visits and Hospitalizations for Digoxin Toxicity United States, 2005 to 2010 SO CIRCULATION-HEART FAILURE LA English DT Article DE digoxin; drug-related side effects and adverse reactions; emergency service; hospital; heart failure; hospitalization ID INVESTIGATION GROUP TRIAL; HEART-FAILURE; DIG TRIAL; DIGITALIS; DRUG; MORTALITY; SURVEILLANCE; MORBIDITY; RISK AB Background Recent data on digoxin prescribing and adverse events are lacking but could help inform the management of digoxin in contemporary heart failure treatment. Methods and Results We determined nationally representative numbers and rates of emergency department (ED) visits for digoxin toxicity in the United States using 2005 to 2010 reports from the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance project and the National Ambulatory (and Hospital Ambulatory) Medical Care Surveys. Based on 441 cases, an estimated 5156 (95% confidence interval [CI], 2663-7648) ED visits for digoxin toxicity occurred annually in the United States; more than three fourths (78.8% [95% CI, 73.5%-84.1%]) resulted in hospitalization. Serum digoxin level was 2.0 ng/mL for 95.8% (95% CI, 93.2%-98.4%) of estimated ED visits with levels reported (n=251 cases). The rate of ED visits per 10 000 outpatient prescription visits among patients 85 years was twice that of patients 40 to 84 years (rate ratio, 2.4 [95% CI, 1.2-5.0]); among women, the rate was twice that of men (rate ratio, 2.3 [95% CI, 1.1-4.7]). Digoxin toxicity accounted for an estimated 1.0% (95% CI, 0.6%-1.4%) of ED visits for all adverse drug events among patients 40 years, but an estimated 3.3% (95% CI, 2.3%-4.4%) of ED visits and 5.9% (95% CI, 4.0%-7.9%) of hospitalizations for all adverse drug events among patients 85 years. Estimated annual ED visits and hospitalizations remained relatively constant from 2005 to 2010. Conclusions Digoxin toxicity is not declining; more careful prescribing to high-risk groups and improved monitoring of serum levels might be needed to reduce morbidity from outpatient digoxin use. C1 [See, Isaac; Shehab, Nadine; Budnitz, Daniel S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [See, Isaac] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Sci Educ & Lab Serv, Atlanta, GA 30333 USA. [Kegler, Scott R.] Ctr Dis Control & Prevent, Div Anal Res & Practice Integrat, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Laskar, S. Raja] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA. RP See, I (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE Mailstop A-24, Atlanta, GA 30333 USA. EM isee@cdc.gov FU Centers for Disease Control and Prevention FX This work was funded by the Centers for Disease Control and Prevention. NR 43 TC 9 Z9 10 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1941-3289 EI 1941-3297 J9 CIRC-HEART FAIL JI Circ.-Heart Fail. PD JAN PY 2014 VL 7 IS 1 BP 28 EP 34 DI 10.1161/CIRCHEARTFAILURE.113.000784 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AA4ND UT WOS:000331071800005 PM 24300242 ER PT J AU See, I Shugart, A Lamb, C Kallen, AJ Patel, PR Sinkowitz-Cochran, RL AF See, Isaac Shugart, Alicia Lamb, Carrie Kallen, Alexander J. Patel, Priti R. Sinkowitz-Cochran, Ronda L. TI Infection Control and Bloodstream Infection Prevention: The Perspective Of Patients Receiving Hemodialysis SO NEPHROLOGY NURSING JOURNAL LA English DT Article DE Bloodstream infections; hemodialysis; infection control; patient education; patient safety ID EDUCATION MODEL AB Patients on hemodialysis, particularly those dialyzed through central lines, are at risk of acquiring bloodstream infections. Strategies to prevent bloodstream infections in patients on dialysis include educating patients about infection prevention, although patients' perspectives on this topic are not known. During focus groups conducted to explore these issues, patients reported that education on infection prevention should begin early in the process of dialysis, and that patients should be actively engaged as partners in infection prevention. C1 [See, Isaac; Shugart, Alicia; Kallen, Alexander J.; Patel, Priti R.; Sinkowitz-Cochran, Ronda L.] Ctr Dis Control & Prevent CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Lamb, Carrie] Dialysis Patient Citizens, Congress & State Relat, Washington, DC USA. RP See, I (reprint author), Ctr Dis Control & Prevent CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. EM isee@cdc.gov FU Intramural CDC HHS [CC999999] NR 10 TC 2 Z9 2 U1 0 U2 1 PU JANNETTI PUBLICATIONS, INC PI PITMAN PA EAST HOLLY AVENUE, BOX 56, PITMAN, NJ 08071-0056 USA SN 1526-744X EI 2163-5390 J9 NEPHROL NURS J JI Nephrol. Nurs. J. PD JAN-FEB PY 2014 VL 41 IS 1 BP 37 EP + PG 4 WC Nursing; Urology & Nephrology SC Nursing; Urology & Nephrology GA AA9PY UT WOS:000331426600005 PM 24689263 ER PT J AU Agwu, AL Chang, JY Wiegand, RE Wheeling, JT Bohannon, BA Dominguez, KL AF Agwu, Allison L. Chang, Jennifer Y. Wiegand, Ryan E. Wheeling, John T. Bohannon, Beverly A. Dominguez, Kenneth L. CA LEGACY Consortium TI Prevalence and Outcomes of Recycling NNRTIs Despite Documented NNRTI Resistance in HIV-Infected Children and Youth SO AIDS PATIENT CARE AND STDS LA English DT Article ID PATIENT-RELATED RISKS; ANTIRETROVIRAL TREATMENT; UNITED-STATES; NEVIRAPINE EXPOSURE; THERAPY; NONADHERENCE; ADOLESCENTS; ADHERENCE; MUTATIONS; FAILURE AB Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are commonly used in pediatric patients; however, rapid development of resistance, due to non-adherence and cross-resistance, results in their discontinuation and limits their recycling. We evaluated the clinical experience of recycling NNRTIs despite documented NNRTI resistance (NNRTI-R), and examined virologic and CD4 cell count outcomes among participants enrolled in Longitudinal Epidemiologic Study to Gain Insight into HIV/AIDS in Children and Youth (LEGACY), a national HIV-infected pediatric cohort. We conducted a retrospective analysis of LEGACY participants with major NNRTI-R. Using chi-square analyses and logistic regression, we examined demographic and clinical factors associated with prescription of NNRTIs despite documented NNRTI-R, and associated changes in plasma HIV RNA viral load and CD4 cell counts. Sixteen of 133 (12%) participants with documented NNRTI-R re-started NNRTIs for a median of 370 days (IQR 105-919) with a median 402 days (IQR 70-841) between documentation of NNRTI-R to NNRTI recycling. Participants recycling NNRTIs were less likely to have documented past non-adherence (40.0% vs. 69.2%; p=0.02). Among twelve patients with virologic data at 24 (+/- 8) weeks; seven (58.3%) experienced virologic suppression while on the recycled NNRTI-based regimens. Of the five who failed to suppress, three with subsequent genotyping developed additional NNRTI-R mutations compromising higher generation NNRTIs. While NNRTI's were recycled in only a small fraction of LEGACY participants harboring NNRTI-R mutations, such recycling increased the risk of inducing further resistance mutations that compromised use of higher generation NNRTIs. C1 [Agwu, Allison L.] Johns Hopkins Med Inst, Dept Pediat Infect Dis, Baltimore, MD 21287 USA. [Chang, Jennifer Y.; LEGACY Consortium] Johns Hopkins Med Inst, Dept Pediat, Baltimore, MD 21287 USA. [Wiegand, Ryan E.; Bohannon, Beverly A.; Dominguez, Kenneth L.] Ctr Dis Control, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Wheeling, John T.] Northrop Grumman Inc, Atlanta, GA USA. RP Agwu, AL (reprint author), Johns Hopkins Med Inst, Dept Pediat Infect Dis, 200 N Wolfe St,Room 3145, Baltimore, MD 21287 USA. EM ageorg10@jhmi.edu FU Centers for Disease Control and Prevention, Atlanta GA [200-2004-09976]; National Institutes of Allergy and Infectious Diseases [1K23 AI084549]; Johns Hopkins Ross Clinician Scientist Award FX The LEGACY project was funded by the Centers for Disease Control and Prevention, Atlanta GA, contract number 200-2004-09976.; Dr. Agwu was supported by the National Institutes of Allergy and Infectious Diseases (1K23 AI084549) and the Johns Hopkins Ross Clinician Scientist Award. NR 18 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 EI 1557-7449 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD JAN 1 PY 2014 VL 28 IS 1 BP 10 EP 14 DI 10.1089/apc.2013.0308 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AA0SX UT WOS:000330808800003 PM 24428795 ER PT J AU Crews, DC Kuczmarski, MF Grubbs, V Hedgeman, E Shahinian, VB Evans, MK Zonderman, AB Burrows, NR Williams, DE Saran, R Powe, NR AF Crews, Deidra C. Kuczmarski, Marie Fanelli Grubbs, Vanessa Hedgeman, Elizabeth Shahinian, Vahakn B. Evans, Michele K. Zonderman, Alan B. Burrows, Nilka Rios Williams, Desmond E. Saran, Rajiv Powe, Neil R. CA Ctr Disease Control & Preven TI Effect of Food Insecurity on Chronic Kidney Disease in Lower-Income Americans SO AMERICAN JOURNAL OF NEPHROLOGY LA English DT Article DE Socioeconomic status; Disparity; Nutrition ID GLOMERULAR-FILTRATION-RATE; SOCIOECONOMIC-STATUS; NATIONAL-HEALTH; RACIAL DISPARITIES; SERUM CREATININE; UNITED-STATES; POVERTY; PREVALENCE; NUTRITION; ALBUMINURIA AB Background: The relation of food insecurity (inability to acquire nutritionally adequate and safe foods) and chronic kidney disease (CKD) is unknown. We examined whether food insecurity is associated with prevalent CKD among lower-income individuals in both the general US adult population and an urban population. Methods: We conducted cross-sectional analyses of lower-income participants of the National Health and Nutrition Examination Survey (NHANES) 2003-2008 (n = 9,126) and the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (n = 1,239). Food insecurity was defined based on questionnaires and CKD was defined by reduced estimated glomerular filtration rate or albuminuria; adjustment was performed with multivariable logistic regression. Results: In NHANES, the age-adjusted prevalence of CKD was 20.3, 17.6, and 15.7% for the high, marginal, and no food insecurity groups, respectively. Analyses adjusting for sociodemographics and smoking status revealed high food insecurity to be associated with greater odds of CKD only among participants with either diabetes (OR = 1.67, 95% CI: 1.14-2.45 comparing high to no food insecurity groups) or hypertension (OR = 1.37, 95% CI: 1.03-1.82). In HANDLS, the age-adjusted CKD prevalence was 5.9 and 4.6% for those with and without food insecurity, respectively (p = 0.33). Food insecurity was associated with a trend towards greater odds of CKD (OR = 1.46, 95% CI: 0.98-2.18) with no evidence of effect modification across diabetes, hypertension, or obesity subgroups. Conclusion: Food insecurity may contribute to disparities in kidney disease, especially among persons with diabetes or hypertension, and is worthy of further study. (C) 2014 S. Karger AG, Basel C1 [Crews, Deidra C.] Johns Hopkins Med Inst, Dept Med, Div Nephrol, Baltimore, MD 21205 USA. [Crews, Deidra C.] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA. [Kuczmarski, Marie Fanelli] Univ Delaware, Dept Behav Hlth & Nutr, Newark, DE USA. [Grubbs, Vanessa] Univ Calif San Francisco, Dept Med, Div Nephrol, San Francisco, CA USA. [Hedgeman, Elizabeth; Shahinian, Vahakn B.; Saran, Rajiv] Univ Michigan, Dept Med, Div Nephrol, Ann Arbor, MI 48109 USA. [Evans, Michele K.; Zonderman, Alan B.] NIA, NIH, Baltimore, MD USA. [Burrows, Nilka Rios; Williams, Desmond E.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Powe, Neil R.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA. RP Crews, DC (reprint author), Johns Hopkins Univ, Sch Med, Div Nephrol, Johns Hopkins Bayview Med Ctr, 301 Mason F Lord Dr,Suite 2500, Baltimore, MD 21224 USA. EM dcrews1@jhmi.edu RI Nguyen, Giang/D-9027-2016 FU CDC [1U58DP003839-01]; Intramural Research Program of the NIA, National Institutes of Health; Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [K23 DK093710]; NIDDK [R01 DK78124] FX This project was supported under a cooperative agreement from the CDC, grant 1U58DP003839-01. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC.; This work was supported by the Intramural Research Program of the NIA, National Institutes of Health. Dr. Crews and Dr. Grubbs were supported by the Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation.; Dr. Grubbs was also supported by grant K23 DK093710 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Dr. Powe was partially supported by grant R01 DK78124 from the NIDDK. NR 52 TC 7 Z9 7 U1 1 U2 10 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0250-8095 EI 1421-9670 J9 AM J NEPHROL JI Am. J. Nephrol. PY 2014 VL 39 IS 1 BP 27 EP 35 DI 10.1159/000357595 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 302VF UT WOS:000330632300005 PM 24434743 ER PT J AU Baillot, A Pelletier, C Dunbar, P Geiss, L Johnson, JA Leiter, LA Langlois, MF AF Baillot, Aurelie Pelletier, Catherine Dunbar, Peggy Geiss, Linda Johnson, Jeffrey A. Leiter, Lawrence A. Langlois, Marie-France TI Profile of adults with type 2 diabetes and uptake of clinical care best practices: Results from the 2011 Survey on Living with Chronic Diseases in Canada - Diabetes component SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Article DE Diabetes; Lifestyle management; Clinical monitoring; Health care ID CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE INTERVENTION; MULTIFACTORIAL INTERVENTION; COST-EFFECTIVENESS; MEDICAL INFORMATION; PRACTICE GUIDELINES; CONTROLLED-TRIAL; GLYCEMIC CONTROL; IMPROVEMENT; PROTECTION AB Aims: This study aimed to (1) describe the profile of adults with type 2 diabetes (T2D) in Canada and (2) assess the uptake of clinical care best practices, as defined by the Canadian Diabetes Association (CDA) Clinical Practice Guidelines (CPGs). Methods: We used data from the 2011 Survey on Living with Chronic Diseases in Canada - Diabetes component. Participants were aged 20 years and older, living in the 10 Canadian provinces, with self-reported T2D. Descriptive analyses present the prevalence of complications and comorbidities, as well as the level of clinical monitoring and self-monitoring/ lifestyle management recommendations participants received. Results: We included 2335 participants with T2D, a mean age of 62.9 years, and high prevalence of complications/comorbidities and prescription medication use. Most participants reported being monitored as recommended for eye disease (73.9%), weight (81.0%), blood pressure (89.0%) and blood cholesterol levels (94.3%), but only 65.5% reported having at least two HbA1c tests during the last year and 46.5% reported an annual foot examination by a health professional. About two-thirds of the participants reported having received recommendations on weight management (59.9%) and physical activity (64.7%) from a health professional in the previous year; only 47.8% of the participants reported having received diet counseling to improve diabetes control. Conclusion: Although the uptake of CDA CPGs for clinical and self-monitoring was high, with the majority of the participants reporting meeting most indicators, it was lower for HbA1c measurement and foot examination. Uptake of lifestyle management recommendations provided by health professionals was also significantly lower. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Baillot, Aurelie; Langlois, Marie-France] Univ Sherbrooke, Div Endocrinol, Dept Med, Etienne LeBel Clin Res Ctr,CHU Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada. [Pelletier, Catherine] Publ Hlth Agcy Canada, Ottawa, ON, Canada. [Dunbar, Peggy] Diabet Care Program Nova Scotia, Halifax, NS, Canada. [Geiss, Linda] Ctr Dis Control & Prevent, Atlanta, GA USA. [Johnson, Jeffrey A.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. [Leiter, Lawrence A.] Univ Toronto, St Michaels Hosp, Li KaShing Knowledge Inst, Div Endocrinol & Metab,Keenan Res Ctr, Toronto, ON, Canada. RP Langlois, MF (reprint author), Univ Sherbrooke, Ctr Hosp, Div Endocrinol, 3001,12E Ave Nord, Sherbrooke, PQ J1H 5N4, Canada. EM Marie-France.Langlois@USherbrooke.ca FU Fonds de la recherche du Quebec Sante (FRQS); FRQS FX Marie-France Langlois is recipient of a National researcher award from the Fonds de la recherche du Quebec Sante (FRQS). The Etienne-LeBel Clinical Research Center is an FRQS funded research center. Jeffrey Johnson is a Senior Scholar with Alberta Innovates-Health Solutions and a Centennial Professor at the University of Alberta. NR 34 TC 3 Z9 4 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-8227 EI 1872-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD JAN PY 2014 VL 103 IS 1 BP 11 EP 19 DI 10.1016/j.diabres.2013.11.022 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 301ZW UT WOS:000330572000002 PM 24369983 ER PT J AU Pridjian, G Sirois, P McRae, R Hinckley, A Rasmussen, S Kissinger, P Buekens, P Hayes, E O'Leary, D Kuhn, S Swan, K Xiong, X Wesson, D AF Pridjian, Gabriella Sirois, Patricia McRae, Robert Hinckley, Alison Rasmussen, Sonja Kissinger, Patricia Buekens, Pierre Hayes, Edward O'Leary, Dan Kuhn, Stephanie Swan, Ken Xiong, Xu Wesson, Dawn TI A prospective study of pregnancy and newborn outcomes in mothers with West Nile virus (WNV) illness during pregnancy SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 34th Annual Scientific Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 03-08, 2014 CL New Orleans, LA SP Soc Maternal Fetal Med C1 [Pridjian, Gabriella; Sirois, Patricia; McRae, Robert; Kissinger, Patricia; Buekens, Pierre; Swan, Ken; Xiong, Xu; Wesson, Dawn] Tulane Univ, New Orleans, LA 70118 USA. [Hinckley, Alison; Hayes, Edward; O'Leary, Dan; Kuhn, Stephanie] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Rasmussen, Sonja] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2014 VL 210 IS 1 SU S BP S197 EP S197 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 298KK UT WOS:000330322600389 ER PT J AU Thompson, J Kuklina, E Bateman, B Callaghan, W James, A Grotegut, C AF Thompson, Jennifer Kuklina, Elena Bateman, Brian Callaghan, William James, Andra Grotegut, Chad TI Medical and pregnancy complications among women with congenital heart disease at delivery SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 34th Annual Scientific Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 03-08, 2014 CL New Orleans, LA SP Soc Maternal Fetal Med C1 [Thompson, Jennifer; Kuklina, Elena; Grotegut, Chad] Duke Univ, Med Ctr, Durham, NC USA. [Kuklina, Elena; Callaghan, William] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bateman, Brian] Harvard Univ, Boston, MA 02115 USA. [James, Andra] Univ Virginia, Charlottesville, VA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2014 VL 210 IS 1 SU S BP S28 EP S28 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 298KK UT WOS:000330322600046 ER PT J AU Rybak, ME Pao, CI Pfeiffer, CM AF Rybak, Michael E. Pao, Ching-I Pfeiffer, Christine M. TI Determination of urine caffeine and its metabolites by use of high-performance liquid chromatography-tandem mass spectrometry: estimating dietary caffeine exposure and metabolic phenotyping in population studies SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Caffeine; Urine; Biomarkers; Dietary intake; Phenotyping; Mass spectrometry; NHANES ID IN-VIVO EVALUATION; XANTHINE-OXIDASE; GENETIC POLYMORPHISMS; EXTRACTIONLESS METHOD; CYP1A2 ACTIVITY; COFFEE; METAANALYSIS; CONSUMPTION; PROBE; METHYLXANTHINES AB We have developed and validated a high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for determining urine caffeine and 14 caffeine metabolites suitable for estimating caffeine exposure and metabolic phenotyping in population studies. Sample preparation consisted solely of a series of simple reagent treatments at room temperature. Stable isotope-labeled analogs were used as internal standards for all analytes. We developed rapid LC-MS/MS separations for both positive and negative ion mode electrospray ionizations to maximize measurement sensitivity. Limits of detection were 0.05-0.1 mu mol/L depending on the analytes. Method imprecision, based on total coefficients of variation, was generally < 7 % when analyte concentration was > 1 mu mol/L. Analyte recoveries were typically within 10 % of being quantitative (100 %), and good agreement was observed among analytes measured across different MS/MS transitions. We applied this method to the analysis of a convenience set of human urine samples (n = 115) and were able to detect a majority of the analytes in a parts per thousand yen99 % of samples as well as calculate caffeine metabolite phenotyping ratios for cytochrome P450 1A2 and N-acetyltransferase 2. Whereas existing LC-MS/MS methods are limited in number of caffeine metabolites for which they are validated, or are designed for studies in which purposely elevated caffeine levels are expected, our method is the first of its kind designed specifically for the rapid, sensitive, accurate, and precise measurement of urine caffeine and caffeine metabolites at concentrations relevant to population studies. C1 [Rybak, Michael E.; Pao, Ching-I; Pfeiffer, Christine M.] US Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Rybak, ME (reprint author), US Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-55, Atlanta, GA 30341 USA. EM MRybak@cdc.gov OI Rybak, Michael/0000-0003-1650-8581 NR 47 TC 10 Z9 11 U1 1 U2 29 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JAN PY 2014 VL 406 IS 3 BP 771 EP 784 DI 10.1007/s00216-013-7506-9 PG 14 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 288QD UT WOS:000329625800012 PM 24306330 ER PT J AU Andacht, TM Pantazides, BG Crow, BS Fidder, A Noort, D Thomas, JD Blake, TA Johnson, RC AF Andacht, Tracy M. Pantazides, Brooke G. Crow, Brian S. Fidder, Alex Noort, Daan Thomas, Jerry D. Blake, Thomas A. Johnson, Rudolph C. TI Enhanced Throughput Method for Quantification of Sulfur Mustard Adducts to Human Serum Albumin Via Isotope Dilution Tandem Mass Spectrometry SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID BETA-LYASE METABOLITES; PROTEIN ADDUCTS; BIOLOGICAL FATE; HUMAN URINE; IMMUNOCHEMICAL DETECTION; SENSITIVE METHOD; IN-VITRO; EXPOSURE; QUANTITATION; PLASMA AB Here, we report an enhanced throughput method for the diagnosis of human exposure to sulfur mustard. A hydroxyethylthioethyl (HETE) ester-adducted tripeptide, produced by pronase digestion of human serum albumin, was selected as the quantitative exposure biomarker. Cibacron Blue enrichment was developed from an established cartridge method into a 96-well plate format, increasing throughput and ruggedness. This new method decreased sample volume 2.5-fold. Addition of a precipitation and solid-phase extraction concentration step increased the sensitivity of the method. With the conversion to a 96-well plate and optimization of chromatography, the method resulted in a 3-fold decrease in analysis time. Inclusion of a confirmation ion has increased specificity. The method was found to be linear between 0.050 and 50 mu M sulfur mustard exposure with a precision for both quality control samples of <= 6.5% relative standard deviation and an accuracy of >96%. The limit of detection (3S(o)) was calculated to be similar to 0.0048 mM, an exposure value similar to that of the HETE-albumin adduct method first described by Noort and co-workers (Noort et al., 1999; Noort el al., 2004) which used protein precipitation to isolate albumin. A convenience set of 124 plasma samples from healthy unexposed individuals was analyzed using this method to assess background levels of exposure to sulfur mustard; no positive results were detected. C1 [Andacht, Tracy M.; Pantazides, Brooke G.; Crow, Brian S.; Thomas, Jerry D.; Blake, Thomas A.; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Fidder, Alex; Noort, Daan] Netherlands Org Appl Sci Res TNO, Rijswijk, Netherlands. RP Johnson, RC (reprint author), Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM rmj6@cdc.gov FU Centers for Disease Control and Prevention; Defense Threat Reduction Agency (DTRA) FX This work was funded by the Centers for Disease Control and Prevention and the Defense Threat Reduction Agency (DTRA). NR 50 TC 7 Z9 7 U1 0 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 EI 1945-2403 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD JAN-FEB PY 2014 VL 38 IS 1 BP 8 EP 15 DI 10.1093/jat/bkt088 PG 8 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 300EA UT WOS:000330446000003 PM 24201816 ER PT J AU Park, J Ahmadi, SF Streja, E Molnar, MZ Flegar, KM Gillen, D Kovesdy, CP Kalantar-Zadeh, K AF Park, Jongha Ahmadi, Seyed-Foad Streja, Elani Molnar, Miklos Z. Flegar, Katherine M. Gillen, Daniel Kovesdy, Csaba P. Kalantar-Zadeh, Kamyar TI Obesity Paradox in End-Stage Kidney Disease Patients SO PROGRESS IN CARDIOVASCULAR DISEASES LA English DT Review DE Obesity paradox; Reverse epidemiology; Dialysis; Visceral fat ID BODY-MASS INDEX; MAINTENANCE HEMODIALYSIS-PATIENTS; INFLAMMATION COMPLEX SYNDROME; CARDIOVASCULAR RISK-FACTORS; CHRONIC HEART-FAILURE; TUMOR-NECROSIS-FACTOR; PERITONEAL-DIALYSIS; REVERSE EPIDEMIOLOGY; RENAL-DISEASE; UNITED-STATES AB In the general population, obesity is associated with increased cardiovascular risk and decreased survival. In patients with end-stage renal disease (ESRD), however, an "obesity paradox" or "reverse epidemiology" (to include lipid and hypertension paradoxes) has been consistently reported, i.e. a higher body mass index (BMI) is paradoxically associated with better survival. This survival advantage of large body size is relatively consistent for hemodialysis patients across racial and regional differences, although published results are mixed for peritoneal dialysis patients. Recent data indicate that both higher skeletal muscle mass and increased total body fat are protective, although there are mixed data on visceral (intra-abdominal) fat. The obesity paradox in ESRD is unlikely to be due to residual confounding alone and has biologic plausibility. Possible causes of the obesity paradox include protein-energy wasting and inflammation, time discrepancy among competitive risk factors (undemutrition versus overnutrition), hemodynamic stability, alteration of circulatory cytokines, sequestration of uremic toxin in adipose tissue, and endotoxin-lipoprotein interaction. The obesity paradox may have significant clinical implications in the management of ESRD patients especially if obese dialysis patients are forced to lose weight upon transplant wait-listing. Well-designed studies exploring the causes and consequences of the reverse epidemiology of cardiovascular risk factors, including the obesity paradox, among ESRD patients could provide more information on mechanisms. These could include controlled trials of nutritional and pharmacologic interventions to examine whether gain in lean body mass or even body fat can improve survival and quality of life in these patients. (C) 2014 Elsevier Inc. All rights reserved. C1 [Park, Jongha; Ahmadi, Seyed-Foad; Streja, Elani; Molnar, Miklos Z.; Gillen, Daniel; Kalantar-Zadeh, Kamyar] Univ Calif Irvine, Sch Med, Harold Simmons Ctr Kidney Dis Res & Epidemiol, Orange, CA 92868 USA. [Park, Jongha] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Div Nephrol, Ulsan 680749, South Korea. [Flegar, Katherine M.] Ctr Dis Control & Prevent CDC, Hyattsville, MD USA. [Gillen, Daniel] Univ Calif Irvine, Dept Stat, Irvine, CA USA. [Kovesdy, Csaba P.] Memphis Vet Affairs Med Ctr, Div Nephrol, Memphis, TN USA. [Kovesdy, Csaba P.] Univ Tennessee, Ctr Hlth Sci, Div Nephrol, Memphis, TN 38163 USA. [Kalantar-Zadeh, Kamyar] UCLA Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA. RP Park, J (reprint author), Ulsan Univ Hosp, 290-3 Jeonha Dong, Ulsan 682714, South Korea. EM jonghaparkmd@gmail.com; kamkal@ucla.edu OI Flegal, Katherine/0000-0002-0838-469X; Molnar, Miklos Z/0000-0002-9665-330X; Kalantar-Zadeh, Kamyar/0000-0002-8666-0725 FU National Institute of Diabetes, Digestive and Kidney Disease [R01-DK078106, R01-DK096920, K24-DK091419]; National Institute on Aging of the National Institutes of Health [R21-AG047036]; Centers for Disease Control and Prevention FX KKZ and CPK are supported by the National Institute of Diabetes, Digestive and Kidney Disease grants R01-DK078106 and R01-DK096920, and KKZ is supported additionally by grant K24-DK091419 and a philanthropist grant from Mr. Harold Simmons. MZM and KKZ are supported by the National Institute on Aging of the National Institutes of Health grant R21-AG047036. Disclaimer: The findings and conclusions in this report are those of the authors and not necessarily of the Centers for Disease Control and Prevention. NR 90 TC 64 Z9 68 U1 0 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0033-0620 EI 1873-1740 J9 PROG CARDIOVASC DIS JI Prog. Cardiovasc. Dis. PD JAN-FEB PY 2014 VL 56 IS 4 BP 415 EP 425 DI 10.1016/j.pcad.2013.10.005 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 297LC UT WOS:000330255900007 PM 24438733 ER PT J AU Flak, AL Su, S Bertrand, J Denny, CH Kesmodel, US Cogswell, ME AF Flak, Audrey L. Su, Su Bertrand, Jacquelyn Denny, Clark H. Kesmodel, Ulrik S. Cogswell, Mary E. TI The Association of Mild, Moderate, and Binge Prenatal Alcohol Exposure and Child Neuropsychological Outcomes: A Meta-Analysis SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Prenatal Alcohol Exposure; Child Neurodevelopment; Systematic Review; Meta-Analysis ID ACADEMIC-ACHIEVEMENT; COGNITIVE DEFICITS; MOTOR DEVELOPMENT; LIGHT DRINKING; TOBACCO USE; AGE 6; PREGNANCY; INFANT; RISK; CONSUMPTION AB BackgroundThe objective of this review is to evaluate the literature on the association between mild, moderate, and binge prenatal alcohol exposure and child neurodevelopment. MethodsMeta-analysis with systematic searches of MEDLINE (1970 through August 2012), EMBASE (1988 through August 2012), and PsycINFO((R)) (1970 through August 2012) and examination of selected references. ResultsFrom 1,593 articles, we identified 34 presenting data from cohort studies that met our inclusion criteria. Information on study population, outcomes, measurement instruments, timing and quantification of alcohol exposure, covariates, and results was abstracted. Outcomes included academic performance, attention, behavior, cognition, language skills, memory, and visual and motor development. The quality of each article was assessed by 2 researchers using the Newcastle-Ottawa Scale. Based on 8 studies of 10,000 children aged 6months through 14years, we observed a significant detrimental association between any binge prenatal alcohol exposure and child cognition (Cohen's d [a standardized mean difference score] -0.13; 95% confidence interval [CI], -0.21, -0.05). Based on 3 high-quality studies of 11,900 children aged 9months to 5years, we observed a statistically significant detrimental association between moderate prenatal alcohol exposure and child behavior (Cohen's d -0.15; 95% CI, -0.28, -0.03). We observed a significant, albeit small, positive association between mild-to-moderate prenatal alcohol exposure and child cognition (Cohen's d 0.04; 95% CI, 0.00, 0.08), but the association was not significant after post hoc exclusion of 1 large study that assessed mild consumption nor was it significant when including only studies that assessed moderate alcohol consumption. None of the other completed meta-analyses resulted in statistically significant associations between mild, moderate, or binge prenatal alcohol exposure and child neuropsychological outcomes. ConclusionsOur findings support previous findings suggesting the detrimental effects of prenatal binge drinking on child cognition. Prenatal alcohol exposure at levels less than daily drinking might be detrimentally associated with child behavior. The results of this review highlight the importance of abstaining from binge drinking during pregnancy and provide evidence that there is no known safe amount of alcohol to consume while pregnant. C1 [Flak, Audrey L.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30332 USA. [Flak, Audrey L.; Su, Su] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Flak, Audrey L.; Bertrand, Jacquelyn; Denny, Clark H.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Su, Su] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Kesmodel, Ulrik S.] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark. [Kesmodel, Ulrik S.] Aarhus Univ Hosp, Dept Obstet & Gynecol, DK-8000 Aarhus, Denmark. [Cogswell, Mary E.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Flak, AL (reprint author), Emory Univ, Dept Epidemiol, CNR 3rd Floor,1518 Clifton Rd,Mailstop 1518-002-3, Atlanta, GA 30332 USA. EM aflak@emory.edu FU Centers for Disease Control and Prevention (CDC); Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy; CDC FX The authors thank Camille Smith, MS, EdS for her work on outcome classifications for this study and Gail Bang, MLIS for her development and completion of the systematic searches. This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention (CDC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 60 TC 57 Z9 57 U1 6 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JAN PY 2014 VL 38 IS 1 BP 214 EP 226 DI 10.1111/acer.12214 PG 13 WC Substance Abuse SC Substance Abuse GA 292EV UT WOS:000329885900026 PM 23905882 ER PT J AU Dorman, SE Belknap, R Graviss, EA Reves, R Schluger, N Weinfurter, P Wang, YP Cronin, W Hirsch-Moverman, Y Teeter, LD Parker, M Garrett, DO Daley, CL AF Dorman, Susan E. Belknap, Robert Graviss, Edward A. Reves, Randall Schluger, Neil Weinfurter, Paul Wang, Yaping Cronin, Wendy Hirsch-Moverman, Yael Teeter, Larry D. Parker, Matthew Garrett, Denise O. Daley, Charles L. CA TB Epidemiologic Studies TI Interferon-gamma Release Assays and Tuberculin Skin Testing for Diagnosis of Latent Tuberculosis Infection in Healthcare Workers in the United States SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE screening; QuantiFERON; T-SPOT.TB; false positive ID QUANTIFERON-TB-GOLD; WITHIN-SUBJECT VARIABILITY; IN-TUBE ASSAY; RESPONSES; CONVERSION AB Rationale: IFN-gamma release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for diagnosis of latent tuberculosis infection. Limited data suggest IGRAs may not perform well for serial testing of healthcare workers (HCWs). Objectives: Determine the performance characteristics of IGRAs versus TST for serial testing of HCWs. Methods: A longitudinal study involving 2,563 HCWs undergoing occupational tuberculosis screening at four healthcare institutions in the United States, where the average tuberculosis case rate ranged from 4 to 9 per 100,000 persons. QuantiFERON-TB Gold In-Tube (QFT-GIT), T-SPOT. TB (T-SPOT), and TST were performed at baseline and every 6 months for 18 months between February 2008 and March 2011. Measurements and Main Results: A total of 2,418 HCWs completed baseline testing, which was positive for 125 (5.2%) by TST, 118 (4.9%) by QFT-GIT, and 144 (6.0%) by T-SPOT. A baseline positive TST with negative IGRAs was associated with bacillus Calmette-Guerin (BCG) vaccination (odds ratio: 25.1 [95% confidence interval: 15.5, 40.5] vs. no BCG). Proportions of participants with test conversion during the study period were 138 of 2,263 (6.1%) for QFT-GIT, 177 of 2,137 (8.3%) for T-SPOT, and 21 of 2,293 (0.9%) for TST (P < 0.001 for QFT-GIT vs. TST and for T-SPOT vs. TST; P = 0.005 for QFT-GIT vs. T-SPOT). Of the QFT-GIT and T-SPOT converters, 81 of 106 (76.4%) and 91 of 118 (77.1%), respectively, were negative when retested 6 months later. There was negative/positive discordance for 15 of 170 (8.8%) participants by QFT-GIT and for 19 of 151 (12.6%) by T-SPOT when blood was drawn 2 weeks later. Conclusions: Most conversions among HCWs in low TB incidence settings appear to be false positives, and these occurred six to nine times more frequently with IGRAs than TST; repeat testing of apparent converters is warranted. C1 [Dorman, Susan E.; Wang, Yaping] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Belknap, Robert; Reves, Randall; Parker, Matthew; Daley, Charles L.] Univ Colorado, Sch Med, Denver, CO USA. [Belknap, Robert; Reves, Randall; Parker, Matthew] Denver Publ Hlth Dept, Denver, CO USA. [Graviss, Edward A.; Teeter, Larry D.] Methodist Hosp Res Inst, Houston, TX USA. [Schluger, Neil; Hirsch-Moverman, Yael] Columbia Univ, CP Felton Natl TB Ctr, Int Ctr AIDS Care & Treatment Programs, Mailman Sch Publ Hlth, New York, NY USA. [Weinfurter, Paul] Westat Corp, Rockville, MD USA. [Cronin, Wendy] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Garrett, Denise O.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Daley, Charles L.] Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA. RP Daley, CL (reprint author), Natl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA. EM daleyc@njhealth.org FU CDC Tuberculosis Epidemiologic Studies Consortium FX Supported by contracts from the CDC Tuberculosis Epidemiologic Studies Consortium to the study sites. Kits and tubes for QuantiFERON-TB Gold In-Tube testing were purchased from Cellestis, Inc, and kits and tubes for T-SPOT. TB testing were purchased from Oxford Immunotec. Technical representatives from Cellestis and Oxford Immunotec provided laboratory training for QuantiFERON-TB Gold and T-SPOT. TB testing, respectively. Neither Cellestis nor Oxford Immunotec had any additional role in design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript. NR 43 TC 73 Z9 74 U1 0 U2 5 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JAN 1 PY 2014 VL 189 IS 1 BP 77 EP 87 DI 10.1164/rccm.201302-0365OC PG 11 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 290UW UT WOS:000329784800016 PM 24299555 ER PT J AU Walter, ND Painter, J Parker, M Lowenthal, P Flood, J Fu, YX Asis, R Reves, R AF Walter, Nicholas D. Painter, John Parker, Matthew Lowenthal, Phillip Flood, Jennifer Fu, Yunxin Asis, Redentor Reves, Randall CA TB Epidemiologic Studies TI Persistent Latent Tuberculosis Reactivation Risk in United States Immigrants SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE United States; epidemiology; emigrants and immigrants; guideline; public health ID FOREIGN-BORN PERSONS; LOW-INCIDENCE COUNTRY; US-BOUND IMMIGRANTS; COST-EFFECTIVENESS; INFECTION; REFUGEES; COHORT; PREVALENCE; CANADA; IMPACT AB Rationale: Current guidelines limit latent tuberculosis infection (LTBI) evaluation to persons in the United States less than or equal to 5 years based on the assumption that high TB rates among recent entrants are attributable to high LTBI reactivation risk, which declines over time. We hypothesized that high postarrival TB rates may instead be caused by imported active TB. Objectives: Estimate reactivation and imported TB in an immigrant cohort. Methods: We linked preimmigration records from a cohort of California-bound Filipino immigrants during 2001-2010 with subsequent TB reports. TB was likely LTBI reactivation if the immigrant had no evidence of active TB at preimmigration examination, likely imported if preimmigration radiograph was abnormal and TB was reported less than or equal to 6 months after arrival, and likely reactivation of inactive TB if radiograph was abnormal but TB was reported more than 6 months after arrival. Measurements and Main Results: Among 123,114 immigrants, 793 TB cases were reported. Within 1 year of preimmigration examination, 85% of TB was imported; 6 and 9% were reactivation of LTBI and inactive TB, respectively. Conversely, during Years 2-9 after U.S. entry, 76 and 24% were reactivation of LTBI and inactive TB, respectively. The rate of LTBI reactivation (32 per 100,000) did not decline during Years 1-9. Conclusions: High postarrival TB rates were caused by detection of imported TB through active postarrival surveillance. Among immigrants without active TB at baseline, reported TB did not decline over 9 years, indicating sustained high risk of LTBI reactivation. Revised guidelines should support LTBI screening and treatment more than 5 years after U.S. arrival. C1 [Walter, Nicholas D.] Univ Colorado Denver, Div Pulm Sci & Crit Care Med, Aurora, CO 80045 USA. [Walter, Nicholas D.; Parker, Matthew; Reves, Randall] Denver Publ Hlth Dept, Denver Metro TB Control Program, Denver, CO USA. [Painter, John] Ctr Dis Control & Prevent, Immigrant Refugee & Migrant Hlth Branch, Div Global Migrat & Quarantine, Atlanta, GA USA. [Lowenthal, Phillip; Flood, Jennifer] Calif Dept Publ Hlth, TB Control Branch, Div Communicable Dis Control, Ctr Infect Dis, Richmond, CA USA. [Fu, Yunxin] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA. [Fu, Yunxin] Univ Texas Hlth Sci Ctr Houston, Div Biostat, Sch Publ Hlth, Houston, TX 77030 USA. [Asis, Redentor] St Lukes Med Ctr Extens Clin, Manila, Philippines. RP Walter, ND (reprint author), Univ Colorado Denver, Div Pulm Sci & Crit Care Med, Anschutz Med Campus,Box C272,9th Floor, Aurora, CO 80045 USA. EM nicholas.walter@ucdenver.edu FU TB Epidemiologic Studies Consortium, U.S. Centers for Disease Control and Prevention; National Institutes of Health [K-12 5K12HL090147-04] FX Supported by TB Epidemiologic Studies Consortium, U.S. Centers for Disease Control and Prevention (M.P., Y.F., and R.R.), and National Institutes of Health grant K-12 5K12HL090147-04 (N.D.W.). NR 43 TC 26 Z9 26 U1 3 U2 7 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JAN 1 PY 2014 VL 189 IS 1 BP 88 EP 95 DI 10.1164/rccm.201308-1480OC PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 290UW UT WOS:000329784800017 PM 24308495 ER PT J AU Piesman, J Hojgaard, A Ullmann, AJ Dolan, MC AF Piesman, Joseph Hojgaard, Andrias Ullmann, Amy J. Dolan, Marc C. TI Efficacy of an Experimental Azithromycin Cream for Prophylaxis of Tick-Transmitted Lyme Disease Spirochete Infection in a Murine Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID BORRELIA-BURGDORFERI INFECTION; SUSTAINED-RELEASE FORMULATION; IXODES-SCAPULARIS ACARI; DOXYCYCLINE HYCLATE; ANAPLASMA-PHAGOCYTOPHILUM; UNITED-STATES; PREVENTION; BITE; IXODIDAE; MICE AB As an alternative to oral prophylaxis for the prevention of tick transmission of Borrelia burgdorferi, we tested antibiotic cream prophylactic formulations in a murine model of spirochete infection. A 4% preparation of doxycycline cream afforded no protection, but a single application of 4% azithromycin cream was 100% protective when applied directly to the tick bite site at the time of tick removal. Indeed, the azithromycin cream was 100% effective when applied at up to 3 days after tick removal and protected 74% of mice exposed to tick bite when applied at up to 2 weeks after tick removal. Azithromycin cream was also protective when applied at a site distal to the tick bite site, suggesting that it was having a systemic effect in addition to a local transdermal effect. Mice that were protected from tick-transmitted infection did not seroconvert and did not infect larval ticks on xenodiagnosis. Azithromycin cream formulations appear to hold promise for Lyme disease prophylaxis. C1 [Piesman, Joseph; Hojgaard, Andrias; Ullmann, Amy J.; Dolan, Marc C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Hojgaard, A (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. EM fth3@cdc.gov NR 30 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2014 VL 58 IS 1 BP 348 EP 351 DI 10.1128/AAC.01932-13 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 287ZL UT WOS:000329581100044 PM 24165183 ER PT J AU Lo, MK Bird, BH Chattopadhyay, A Drew, CP Martin, BE Coleman, JD Rose, JK Nichol, ST Spiropoulou, CF AF Lo, Michael K. Bird, Brian H. Chattopadhyay, Anasuya Drew, Clifton P. Martin, Brock E. Coleman, Joann D. Rose, John K. Nichol, Stuart T. Spiropoulou, Christina F. TI Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters SO ANTIVIRAL RESEARCH LA English DT Article DE Henipavirus; Nipah; Vaccine; VSV; Single-dose; Hamster ID VESICULAR STOMATITIS-VIRUS; LONG-TERM PROTECTION; SUBUNIT VACCINE; HENIPAVIRUS INFECTION; IMMUNE-RESPONSES; COMPETENT VECTOR; PARAMYXOVIRUS; PROTEIN; MODEL; MICE AB Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans. Published by Elsevier B.V. C1 [Lo, Michael K.; Bird, Brian H.; Martin, Brock E.; Coleman, Joann D.; Nichol, Stuart T.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [Drew, Clifton P.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. [Chattopadhyay, Anasuya; Rose, John K.] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA. RP Lo, MK (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, 1600 Clifton Rd,Mailstop G-14, Atlanta, GA 30333 USA. EM mko2@cdc.gov; ccs8@cdc.gov OI Lo, Michael/0000-0002-0409-7896 FU NIH Northeast Biodefense Center Grant [U54-AI057158] FX We thank Mr. Eddie Jackson for assistance with implanting temperature/identification transponders in the hamsters, and Peter J. Eworonsky, Abiola Aminu, and Lester E. Slough for assistance in animal care and husbandry. The findings and conclusions in this report are those of the authors and do not necessarily represent those of the Centers for Disease Control and Prevention. This work was supported in part by NIH Northeast Biodefense Center Grant U54-AI057158. NR 34 TC 9 Z9 10 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD JAN PY 2014 VL 101 BP 26 EP 29 DI 10.1016/j.antiviral.2013.10.012 PG 4 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 290QF UT WOS:000329772700003 PM 24184127 ER PT J AU Mishin, VP Sleeman, K Levine, M Carney, PJ Stevens, J Gubareva, LV AF Mishin, Vasiliy P. Sleeman, Katrina Levine, Marnie Carney, Paul J. Stevens, James Gubareva, Larisa V. TI The effect of the MDCK cell selected neuraminidase D151G mutation on the drug susceptibility assessment of influenza A(H3N2) viruses SO ANTIVIRAL RESEARCH LA English DT Article DE Neuraminidase inhibition assay; Pyrosequencing; Recombinant protein; NA-Star (R) kit; NA-Fluor (TM) kit ID INHIBITOR RESISTANCE; SURVEILLANCE; SITE AB Propagation of influenza A(H3N2) viruses in MDCK cells has been associated with the emergence of neuraminidase (NA) variants carrying a change at residue 151. In this study, the pyrosequencing assay revealed that similar to 90% of A(H3N2) virus isolates analyzed (n = 150) contained more than one amino acid variant (D/G/N) at position 151. Susceptibilities of the virus isolates to zanamivir and oseltamivir were assessed using the chemiluminescent and fluorescent NA inhibition (NI) assays. In the chemiluminescent assay, which utilizes NA-Star (R) substrate, up to 13-fold increase in zanamivir-IC50 was detected for isolates containing a high proportion (>50%) of the G151 NA variant. However, an increase in zanamivir-IC(50)s was not seen in the fluorescent assay, which uses MUNANA as substrate. To investigate this discrepancy, recombinant NAs (rNAs) were prepared and tested in both NI assays. Regardless of the assay used, the zanamivir-IC50 for the rNA G151 was much greater (>1500-fold) than that for rNA D151 wildtype. However, zanamivir resistance conferred by the G151 substitution was masked in preparations containing the D151 NA which had much greater activity, especially against MUNANA. In conclusion, the presence of NA D151G variants in cell culture-grown viruses interferes with drug susceptibility assessment and therefore measures need to be implemented to prevent their emergence. Published by Elsevier B.V. C1 [Mishin, Vasiliy P.; Sleeman, Katrina; Levine, Marnie; Carney, Paul J.; Stevens, James; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Virus Surveillance & Diag Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Levine, Marnie] Battelle Mem Inst, Atlanta, GA 30333 USA. RP Gubareva, LV (reprint author), Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM LGubareva@cdc.gov NR 13 TC 12 Z9 12 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD JAN PY 2014 VL 101 BP 93 EP 96 DI 10.1016/j.antiviral.2013.11.001 PG 4 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 290QF UT WOS:000329772700012 PM 24239666 ER PT J AU Jaacks, LM Bell, RA Dabelea, D D'Agostino, RB Dolan, LM Imperatore, G Klingensmith, G Lawrence, JM Saydah, S Yi-Frazier, J Mayer-Davis, EJ AF Jaacks, Lindsay M. Bell, Ronny A. Dabelea, Dana D'Agostino, Ralph B., Jr. Dolan, Lawrence M. Imperatore, Giuseppina Klingensmith, Georgeanna Lawrence, Jean M. Saydah, Sharon Yi-Frazier, Joyce Mayer-Davis, Elizabeth J. CA SEARCH Diabet Youth Study Grp TI Diabetes Self-Management Education Patterns in a US Population-Based Cohort of Youth With Type 1 Diabetes SO DIABETES EDUCATOR LA English DT Editorial Material ID YOUNG-PEOPLE; ADOLESCENTS; PREVALENCE; MELLITUS; CHILDREN; SEARCH; ASSOCIATION; KNOWLEDGE; OUTCOMES; SUPPORT AB Purpose The purpose of this study is to describe (1) the receipt of diabetes self-management education (DSME) in a large, diverse cohort of US youth with type 1 diabetes (T1DM), (2) the segregation of self-reported DSME variables into domains, and (3) the demographic and clinical characteristics of youth who receive DSME. Methods Data are from the US population-based cohort SEARCH for Diabetes in Youth. A cross-sectional analysis was employed using data from 1273 youth <20 years of age at the time of diagnosis of T1DM. Clusters of 19 self-reported DSME variables were derived using factor analysis, and their associations with demographic and clinical characteristics were evaluated using polytomous logistic regression. Results Nearly all participants reported receiving DSME content consistent with survival skills (eg, target blood glucose and what to do for low or high blood glucose), yet gaps in continuing education were identified (eg, fewer than half of the participants reported receiving specific medical nutrition therapy recommendations). Five DSME clusters were explored: receipt of specific MNT recommendations, receipt of diabetes information resources, receipt of clinic visit information, receipt of specific diabetes information, and met with educator or nutritionist. Factor scores were significantly associated with demographic and clinical characteristics, including race/ethnicity, socioeconomic status, and diabetes self-management practices. Conclusions Health care providers should work together to address reported gaps in DSME to improve patient care. C1 [Jaacks, Lindsay M.; Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA. [Bell, Ronny A.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA. [Dabelea, Dana; Klingensmith, Georgeanna] Univ Colorado, Dept Pediat, Denver, CO 80202 USA. [Dabelea, Dana; Klingensmith, Georgeanna] Univ Colorado, Barbara Davis Ctr, Denver, CO 80202 USA. [D'Agostino, Ralph B., Jr.] Wake Forest Sch Med, Dept Biostat, Winston Salem, NC USA. [Dolan, Lawrence M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Imperatore, Giuseppina; Saydah, Sharon] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lawrence, Jean M.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Yi-Frazier, Joyce] Seattle Childrens Hosp, Seattle, WA USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA. RP Mayer-Davis, EJ (reprint author), Univ N Carolina, 2211 McGavran Greenberg Hall,135 Dauer Dr, Chapel Hill, NC 27599 USA. EM mayerdav@email.unc.edu RI Dagostino Jr, Ralph/C-4060-2017 OI Dagostino Jr, Ralph/0000-0002-3550-8395 FU HSRD VA [HIR 10-001]; NCATS NIH HHS [UL1 TR001082]; NCCDPHP CDC HHS [DP-05-069, 1U18DP002709, DP-10-001, U01 DP000244, U01 DP000246, U01 DP000247, U01 DP000248, U01 DP000250, U01 DP000254, U18 DP002708, U18 DP002709, U18 DP002710, U18 DP002714, U18DP000247-06A1, U18DP002708-01, U18DP002710-01, U18DP002714]; NCRR NIH HHS [M01 RR000037, M01 RR000069, M01RR00037, M01RR00069, UL1 RR025014, UL1 RR026314, UL1 RR029882, UL1RR026314-01, UL1RR029882]; NIDDK NIH HHS [K23 DK089017, P30 DK057516, P30DK57516]; PHS HHS [00097, 200-2010-35171, U48/CCU419249, U48/CCU519239, U48/CCU819241-3, U48/CCU919219, U58/CCU019235-4] NR 31 TC 1 Z9 1 U1 0 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0145-7217 EI 1554-6063 J9 DIABETES EDUCATOR JI Diabetes Educ. PD JAN PY 2014 VL 40 IS 1 BP 29 EP 39 DI 10.1177/0145721713512156 PG 11 WC Endocrinology & Metabolism; Public, Environmental & Occupational Health SC Endocrinology & Metabolism; Public, Environmental & Occupational Health GA 291YU UT WOS:000329869600001 PM 24248833 ER PT J AU Quarles, CD Jones, DR Jarrett, JM Shakirova, G Pan, Y Caldwell, KL Jones, RL AF Quarles, C. Derrick, Jr. Jones, Deanna R. Jarrett, Jeffery M. Shakirova, Gulchekhra Pan, Yi Caldwell, Kathleen L. Jones, Robert L. TI Analytical method for total chromium and nickel in urine using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) in kinetic energy discrimination (KED) mode SO JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY LA English DT Article ID TRACE-ELEMENTS; WHOLE-BLOOD; METAL; HIP; INTERFERENCES; COLLISION; GAS AB Biomonitoring and emergency response measurements are an important aspect of the Division of Laboratory Sciences of the National Center for Environmental Health, Centers for Disease Control and Prevention (CDC). The continuing advancement in instrumentation allows for enhancements to existing analytical methods. Prior to this work, chromium and nickel were analyzed on a sector field inductively coupled plasma-mass spectrometer (SF-ICP-MS). This type of instrumentation provides the necessary sensitivity, selectivity, accuracy, and precision but due to the higher complexity of instrumentation and operation, it is not preferred for routine high throughput biomonitoring needs. Instead a quadrupole based method has been developed on a PerkinElmer NexION (TM) 300D ICP-MS. The instrument is operated using 6.0 mL min(-1) helium as the collision cell gas and in kinetic energy discrimination mode, interferences are successfully removed for the analysis of Cr-52 ((ArC)-Ar-40-C-12 and (ClOH)-Cl-35-O-16-H-1) and Ni-60 ((CaO)-Ca-44-O-16). The limits of detection are 0.162 mu g L-1 Cr and 0.248 mu g L-1 Ni. Method accuracy using NIST SRM 2668 level 1 (1.08 mu g L-1 Cr and 2.31 mu g L-1 Ni) and level 2 (27.7 mu g L-1 Cr and 115 mu g L-1 Ni) was within the 95% confidence intervals reported in the NIST certificate. Among-run precision is less than 10% RSDs (N = 20) for in house quality control and NIST SRM urine samples. While the limits of detection (LOD) for the new quadrupole ICP-UCT-MS with KED method are similar to the SF-ICP-MS method, better measurement precision is observed for the quadrupole method. The new method presented provides fast, accurate, and more precise results on a less complex and more robust ICP-MS platform. C1 [Quarles, C. Derrick, Jr.; Jones, Deanna R.; Jarrett, Jeffery M.; Shakirova, Gulchekhra; Pan, Yi; Caldwell, Kathleen L.; Jones, Robert L.] Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Quarles, CD (reprint author), Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, Natl Ctr Environm Hlth, 4770 Buford Highway,Mailstop F-18, Atlanta, GA 30341 USA. EM dquarles@appliedspectra.com OI Jarrett, Jeffery/0000-0001-5755-3552 NR 26 TC 4 Z9 4 U1 2 U2 22 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0267-9477 EI 1364-5544 J9 J ANAL ATOM SPECTROM JI J. Anal. At. Spectrom. PY 2014 VL 29 IS 2 BP 297 EP 303 DI 10.1039/c3ja50272d PG 7 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA 292WS UT WOS:000329934000010 ER PT J AU Agaku, IT King, BA Dube, SR AF Agaku, Israel T. King, Brian A. Dube, Shanta R. TI Trends in exposure to pro-tobacco advertisements over the Internet, in newspapers/magazines, and at retail stores among US middle and high school students, 2000-2012 SO PREVENTIVE MEDICINE LA English DT Article DE Advertising; School; Smoking; Prevalence; Tobacco; Health promotion; Youths ID NEIGHBORHOODS; INDUSTRY; HEALTH AB Background. Most tobacco use begins during youth. Thus, this study assessed the prevalence, trends, and correlates of pro-tobacco advertising among United States students in grades 6-12 during 2000-2012. Methods. Data from the 2000-2012 National Youth Tobacco Survey were analyzed to assess self-reported exposure to pro-tobacco advertisements through three media: over the Internet, in newspapers/magazines, and at retail stores. Trends during 2000-2012 were assessed in a binary logistic regression model (P < 0.05). Results. Among all middle and high school students, the overall prevalence of exposure to Internet pro-tobacco advertisements increased from 22.3% to 43.0% during 2000-2012 (P < 0.001 for linear trend). During the same period, declines were observed in the overall prevalence of exposure to pro-tobacco advertisements in newspapers/magazines (65.0% to 36.9%) and at retail stores (87.8% to 76.2%) (P < 0.001 for all linear trends). Conclusion. Exposure to pro-tobacco advertisements over the Internet increased significantly during 2000-2012 among United States middle and high school students, while a decline in exposure to advertisements in newspapers or magazines, and at retail stores occurred during the same period. However, over two-thirds of students still reported retail store exposure to pro-tobacco advertisements in 2012. Enhanced and sustained efforts would be beneficial to reduce even more exposure to all forms of pro-tobacco advertisements among youths. Published by Elsevier Inc. C1 [Agaku, Israel T.; King, Brian A.; Dube, Shanta R.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Agaku, Israel T.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Appl Sci, Sci Educ & Profess Dev Program Off, Atlanta, GA 30341 USA. RP Agaku, IT (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, CDC, 4770 Buford Highway,MS K-50, Atlanta, GA 30341 USA. EM iagaku@cdc.gov; baking@cdc.gov; skd7@cdc.gov NR 27 TC 4 Z9 4 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD JAN PY 2014 VL 58 BP 45 EP 52 DI 10.1016/j.ypmed.2013.10.012 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 295AL UT WOS:000330088900007 PM 24183778 ER PT J AU Ghandour, RM Hirai, AH Blumberg, SJ Strickland, BB Kogan, MD AF Ghandour, Reem M. Hirai, Ashley H. Blumberg, Stephen J. Strickland, Bonnie B. Kogan, Michael D. TI Financial and Nonfinancial Burden Among Families of CSHCN: Changes Between 2001 and 2009-2010 SO ACADEMIC PEDIATRICS LA English DT Article DE children with special health care needs; family burden; financial burden; trends ID HEALTH-CARE NEEDS; NATIONAL PROFILE; UNITED-STATES; CHILDREN; EXPENDITURES; IMPACT; DISABILITY; DISORDERS; CHILDHOOD; ACCESS AB OBJECTIVE: We use the latest data to explore multiple dimensions of financial burden among children with special health care needs (CSHCN) and their families in 2009-2010 and changes since 2001. METHODS: Five burden indicators were assessed using the 2001 and 2009-2010 National Surveys of CSHCN: past-year health-related out-of-pocket expenses of >=$1,000 or >= 3% of household income; perceived financial problems; changes in family employment; and >10 hours of weekly care provision/coordination. Unadjusted and adjusted prevalence estimates were used to assess burden in 2009-2010 and calculate absolute and relative measures of change since 2001. Prevalence rate ratios for each burden type in 2009-2010 compared to 2001 were estimated by logistic regression. RESULTS: Nearly half of CSHCN and their families experienced some form of burden in 2009-2010. The percentage of CSHCN living in families that paid >=$1,000 or >= 3% of house-hold income out of pocket for health care rose 120% and 35%, respectively, between 2001 and 2009-2010, while the prevalence of caregiving and employment burdens declined. Relative to 2001, in 2009-2010, CSHCN who were privately insured or least affected by their conditions were 1.7 times as likely to live in families that paid >= 3% of household income out of pocket, while publicly insured children were 20% less likely to do so and those most severely affected were 12% more likely to do so. CONCLUSIONS: Over the past decade, increases in financial burden and declines in employment and caregiving burdens were observed for CSHCN families. Public insurance expansions may have buffered increases in financial burden, yet disparities persist. C1 [Ghandour, Reem M.; Hirai, Ashley H.; Kogan, Michael D.] Hlth Resources & Serv Adm, Off Epidemiol & Res, Maternal & Child Hlth Bur, US Dept Hlth & Human Serv, Rockville, MD 20857 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, US Dept Hlth & Human Serv, Div Hlth Interview Stat, Hyattsville, MD 20782 USA. [Strickland, Bonnie B.] Hlth Resources & Serv Adm, US Dept Hlth & Human Serv, Maternal & Child Hlth Bur, Div Serv Children Special Hlth Care Needs, Rockville, MD 20857 USA. RP Ghandour, RM (reprint author), Hlth Resources & Serv Adm, Off Epidemiol & Res, Maternal & Child Hlth Bur, US Dept Hlth & Human Serv, 5600 Fishers Ln,Room 18-41, Rockville, MD 20857 USA. EM rghandour@hrsa.gov FU Intramural CDC HHS [CC999999] NR 35 TC 9 Z9 9 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1876-2859 EI 1876-2867 J9 ACAD PEDIATR JI Acad. Pediatr. PD JAN-FEB PY 2014 VL 14 IS 1 BP 92 EP 100 PG 9 WC Pediatrics SC Pediatrics GA 287SS UT WOS:000329563100015 PM 24369874 ER PT J AU Caraballo, RS Kruger, J Asman, K Pederson, L Widome, R Kiefe, CI Hitsman, B Jacobs, DR AF Caraballo, Ralph S. Kruger, Judy Asman, Kat Pederson, Linda Widome, Rachel Kiefe, Catarina I. Hitsman, Brian Jacobs, David R., Jr. TI Relapse among Cigarette Smokers: The CARDIA longitudinal study-1985-2011 SO ADDICTIVE BEHAVIORS LA English DT Article DE Relapse; Cessation; Cigarette; Smoking; Abstinence ID SMOKING-CESSATION; TRAJECTORIES; DEPENDENCE; RISK; US AB Rationale: There is little information about long-term relapse patterns for cigarette smokers. Objective: To describe long-term prevalence of relapse and related smoking patterns by sex, race, age, and education level among a community-based cohort of young adults followed for 25 years. Methods: We examined 25 years of data from Coronary Artery Risk Development in Young Adults (CARDIA), an ongoing study of a community-based cohort of 5115 men and women aged 18 to 30 years at baseline with periodic re-examinations. At each examination smoking, quitting, and relapse were queried. We examined prevalence of smoking relapse among 3603 participants who attended at least 6 of the 8 examinations. Results: About 53% of 3603 participants never reported smoking on a regular basis. Among the remaining 1682 ever smokers, 52.8% of those who reported current smoking at baseline were still smoking by the end of the study, compared to 10.7% of those who initiated smoking by year 5. Among those classified as former smokers at baseline, 39% relapsed at least once; of these, 69.5% had quit again by the end of the study. Maximum education level attained, age at study baseline, and race were associated with failure to quit smoking by the end of the study and relapse among those who did quit Maximum education level attained and age at study baseline were also associated with ability to successfully quit after a relapse. Conclusions: Smoking relapse after quitting is common, especially in those with lower education level. Education was the strongest predictor of all three outcomes. Improvements in access to treatment and treatment options, especially for underserved populations, are needed to prevent relapse when smokers quit. Published by Elsevier Ltd. C1 [Caraballo, Ralph S.; Kruger, Judy] Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Epidemiol Branch, Atlanta, GA 30341 USA. [Asman, Kat; Pederson, Linda] RTI Int, Stat & Epidemiol Unit, Atlanta, GA 30341 USA. [Pederson, Linda] McKing Consulting Corp, Atlanta, GA 30341 USA. [Widome, Rachel; Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55454 USA. [Kiefe, Catarina I.] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Worcester, MA 01655 USA. [Hitsman, Brian] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA. RP Caraballo, RS (reprint author), Off Smoking & Hlth, Epidemiol Branch, 4770 Buford Highway,M-S K-50, Atlanta, GA 30341 USA. EM rfc8@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 9 Z9 9 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 EI 1873-6327 J9 ADDICT BEHAV JI Addict. Behav. PD JAN PY 2014 VL 39 IS 1 BP 101 EP 106 DI 10.1016/j.addbeh.2013.08.030 PG 6 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 287RQ UT WOS:000329560300013 PM 24172753 ER PT J AU Diallo, K Lehotzky, E Zhang, J Zhou, ZY de Rivera, IL Murillo, WE Nkengasong, J Sabatier, J Zhang, GQ Yang, CF AF Diallo, Karidia Lehotzky, Erica Zhang, Jing Zhou, Zhiyong de Rivera, Ivette Lorenzana Murillo, Wendy E. Nkengasong, John Sabatier, Jennifer Zhang, Guoqing Yang, Chunfu TI Evaluation of a Dried Blood and Plasma Collection Device, SampleTanker (R), for HIV Type 1 Drug Resistance Genotyping in Patients Receiving Antiretroviral Therapy SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SPOT SPECIMENS; FILTER PAPERS; RNA; ASSAY; EXTRACTION; DIAGNOSIS; DATABASE; INFANTS; STORAGE AB Whatman 903 filter paper is the only filter paper that has been used for HIV drug resistance (HIVDR) genotyping in resource-limited settings. In this study, we evaluated another dried blood specimen collection device, termed SampleTanker((R)) (ST), for HIVDR genotyping. Blood specimens from 123 antiretroviral therapy (ART)-experienced patients were used to prepare ST whole blood and ST plasma specimens; they were then stored at ambient temperature for 2 or 4 weeks. The remaining plasma specimens were stored at -80 degrees C and used as frozen plasma controls. Frozen plasma viral load (VL) was determined using the Roche Amplicor HIV-1 Monitor test, v.1.5 and 50 specimens with VL 3.00 log(10) copies/ml were genotyped using the broadly sensitive genotyping assay. The medium VL for the 50 frozen plasma specimens with VL 3.00 log(10) was 3.58 log(10) copies/ml (IQR: 3.32-4.11) and 96.0% (48/50) of them were genotyped. Comparing to frozen plasma specimens, significantly lower genotyping rates were obtained from ST whole blood (48.98% and 42.85%) and ST plasma specimens (36.0% and 36.0%) stored at ambient temperature for 2 and 4 weeks, respectively (p<0.001). Nucleotide sequence identity and resistance profile analyses between the matched frozen plasma and ST whole blood or ST plasma specimens revealed high nucleotide sequence identities and concordant resistance profiles (98.1% and 99.0%, and 96.6% and 98.9%, respectively). Our results indicate that with the current design, the ST may not be the ideal dried blood specimen collection device for HIVDR monitoring for ART patients in resource-limited settings. C1 [Diallo, Karidia; Lehotzky, Erica; Zhang, Jing; Zhou, Zhiyong; Nkengasong, John; Zhang, Guoqing; Yang, Chunfu] Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, CGH, Atlanta, GA 30333 USA. [de Rivera, Ivette Lorenzana; Murillo, Wendy E.] UNAH, Tegucigalpa, Honduras. [Sabatier, Jennifer] Ctr Dis Control & Prevent, Strateg Informat & Epidemiol Branch, Div Global HIV AIDS, CGH, Atlanta, GA 30333 USA. RP Yang, CF (reprint author), Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, CGH, Mail Stop A-11,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM cyang1@cdc.gov RI Zhang, Guoqing/C-9523-2014; Yang, Chunfu/G-6890-2013 FU American Public Health Laboratory (APHL); CDC; Centers for Disease Control and Prevention FX Dr. Guoqing Zhang was a recipient of the 2010-2011 International Emerging Infectious Fellowship (IEID) sponsored by the American Public Health Laboratory (APHL) and CDC. This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention. NR 30 TC 4 Z9 4 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JAN 1 PY 2014 VL 30 IS 1 BP 67 EP 73 DI 10.1089/aid.2013.0127 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 284BO UT WOS:000329291200012 PM 23944768 ER PT J AU Shvedova, AA Yanamala, N Kisin, ER Tkach, AV Murray, AR Hubbs, A Chirila, MM Keohavong, P Sycheva, LP Kagan, VE Castranova, V AF Shvedova, Anna A. Yanamala, Naveena Kisin, Elena R. Tkach, Alexey V. Murray, Ashley R. Hubbs, Ann Chirila, Madalina M. Keohavong, Phouthone Sycheva, Lyudmila P. Kagan, Valerian E. Castranova, Vincent TI Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY LA English DT Article DE nanoparticles; long-term postexposure; inflammation; fibrosis; genotoxicity ID HUMAN MESOTHELIAL CELLS; NF-KAPPA-B; TUMOR-SUPPRESSOR; EPITHELIAL-CELLS; MOUSE LUNG; IN-VITRO; CYSTEINE CATHEPSINS; GLUCOSE-METABOLISM; PROTEOME ANALYSIS; OXIDATIVE STRESS AB The hallmark geometric feature of single-walled carbon nanotubes (SWCNT) and carbon nanofibers (CNF), high length to width ratio, makes them similar to a hazardous agent, asbestos. Very limited data are available concerning long-term effects of pulmonary exposure to SWCNT or CNF. Here, we compared inflammatory, fibrogenic, and genotoxic effects of CNF, SWCNT, or asbestos in mice 1 yr after pharyngeal aspiration. In addition, we compared pulmonary responses to SWCNT by bolus dosing through pharyngeal aspiration and inhalation 5 h/day for 4 days, to evaluate the effect of dose rate. The aspiration studies showed that these particles can be visualized in the lung at 1 yr postexposure, whereas some translocate to lymphatics. All these particles induced chronic bronchopneumonia and lymphadenitis, accompanied by pulmonary fibrosis. CNF and asbestos were found to promote the greatest degree of inflammation, followed by SWCNT, whereas SWCNT were the most fibrogenic of these three particles. Furthermore, SWCNT induced cytogenetic alterations seen as micronuclei formation and nuclear protrusions in vivo. Importantly, inhalation exposure to SWCNT showed significantly greater inflammatory, fibrotic, and genotoxic effects than bolus pharyngeal aspiration. Finally, SWCNT and CNF, but not asbestos exposures, increased the incidence of K-ras oncogene mutations in the lung. No increased lung tumor incidence occurred after 1 yr postexposure to SWCNT, CNF, and asbestos. Overall, our data suggest that long-term pulmonary toxicity of SWCNT, CNF, and asbestos is defined, not only by their chemical composition, but also by the specific surface area and type of exposure. C1 [Shvedova, Anna A.; Yanamala, Naveena; Kisin, Elena R.; Tkach, Alexey V.; Murray, Ashley R.; Hubbs, Ann; Chirila, Madalina M.; Castranova, Vincent] NIOSH, CDC, Morgantown, WV 26505 USA. [Keohavong, Phouthone; Kagan, Valerian E.] Univ Pittsburgh, Pittsburgh, PA USA. [Sycheva, Lyudmila P.] Sysin Res Inst Human Ecol & Environm, Moscow, Russia. RP Shvedova, AA (reprint author), NIOSH, CDC, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM ats1@cdc.gov OI Keohavong, Phouthone/0000-0001-7812-4925; Sycheva, Lyudmila/0000-0002-7370-0169 FU NTRC Grant [3927ZJHF]; NIOSH Grant [OH008282]; NIH [R01 ES-019304, HL-070755, U19 AI-068021] FX This work was supported by NTRC Grant 3927ZJHF (A. Shvedova), NIOSH Grant OH008282, and NIH Grants R01 ES-019304, HL-070755, and U19 AI-068021 (V. Kagan). NR 85 TC 32 Z9 33 U1 0 U2 20 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1040-0605 EI 1522-1504 J9 AM J PHYSIOL-LUNG C JI Am. J. Physiol.-Lung Cell. Mol. Physiol. PD JAN PY 2014 VL 306 IS 2 BP L170 EP L182 DI 10.1152/ajplung.00167.2013 PG 13 WC Physiology; Respiratory System SC Physiology; Respiratory System GA 291VC UT WOS:000329858000007 PM 24213921 ER PT J AU Eberhard, ML Ruiz-Tiben, E Hopkins, DR Farrell, C Toe, F Weiss, A Withers, PC Jenks, MH Thiele, EA Cotton, JA Hance, Z Holroyd, N Cama, VA Tahir, MA Mounda, T AF Eberhard, Mark L. Ruiz-Tiben, Ernesto Hopkins, Donald R. Farrell, Corey Toe, Fernand Weiss, Adam Withers, P. Craig, Jr. Jenks, M. Harley Thiele, Elizabeth A. Cotton, James A. Hance, Zahra Holroyd, Nancy Cama, Vitaliano A. Tahir, Mahamat Ali Mounda, Tchonfienet TI The Peculiar Epidemiology of Dracunculiasis in Chad SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DNA-SEQUENCING DATA; 18S RIBOSOMAL-RNA; GENOME; ERADICATION; MEDINENSIS; DISCOVERY; FRAMEWORK; INSIGNIS AB Dracunculiasis was rediscovered in Chad in 2010 after an apparent absence of 10 years. In April 2012 active village-based surveillance was initiated to determine where, when, and how transmission of the disease was occurring, and to implement interventions to interrupt it. The current epidemiologic pattern of the disease in Chad is unlike that seen previously in Chad or other endemic countries, i.e., no clustering of cases by village or association with a common water source, the average number of worms per person was small, and a large number of dogs were found to be infected. Molecular sequencing suggests these infections were all caused by Dracunculus medinensis. It appears that the infection in dogs is serving as the major driving force sustaining transmission in Chad, that an aberrant life cycle involving a paratenic host common to people and dogs is occurring, and that the cases in humans are sporadic and incidental. C1 Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Ruiz-Tiben, Ernesto; Hopkins, Donald R.; Weiss, Adam; Withers, P. Craig, Jr.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Farrell, Corey; Toe, Fernand] Carter Ctr, Ndjamena, Chad. LifeSource Biomed, Centreville, VA USA. Wellcome Trust Sanger Inst, Hinxton, England. [Tahir, Mahamat Ali; Mounda, Tchonfienet] Minist Publ Hlth, Ndjamena, Chad. [Eberhard, Mark L.; Jenks, M. Harley; Thiele, Elizabeth A.; Cama, Vitaliano A.] CDC, Div Parasit Dis, Atlanta, GA 30333 USA. [Cotton, James A.; Hance, Zahra; Holroyd, Nancy] Wellcome Trust Sanger Inst, Cambridge, England. RP Eberhard, ML (reprint author), CDC, Div Parasit Dis & Malaria, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM meberhard@cdc.gov; eruizti@emory.edu; sdsulli@emory.edu; clfarrel12@gmail.com; fernandtoe@gmail.com; adam.j.weiss@emory.edu; cwither@emory.edu; uwq1@cdc.gov; xas4@cdc.gov; james.cotton@sanger.ac.uk; za1@sanger.ac.uk; neh@sanger.ac.uk; vcama@cdc.gov; mahamat_tahir2@yahoo.fr; tchomcalvin@yahoo.fr RI Cotton, James/B-8806-2008; Thiele, Elizabeth/F-2590-2016 OI Cotton, James/0000-0001-5475-3583; Thiele, Elizabeth/0000-0001-9235-2019 FU NTD Department; WHO; Next Generation Fund of the Hugh J. Andersen Foundation; Apple Computer, Inc.; Arab Fund for Economic and Social Development; Atlanta Woman's Club; BASF Corporation; Canadian International Development Agency; Chevron Corporation; Children's Investment Fund Foundation UK; Crawford Family Foundation; Delta Medical Supplies; Edgar O. Dixon Charitable Trust; Elfenworks Foundation; First Congregational Church; Foundation Source; Bill & Melinda Gates Foundation; General Electric Company; Girl Scouts of America Brownie Troop 861; Global Aviation Holdings; Global Health Education Consortium, Inc.; Google, Inc.; Robert and Shirley Harris Family Foundation; Harris myCFO Foundation; Conrad N. Hilton Foundation; John C. and Karyl Kay Hughes Foundation; John P. Hussman Foundation, Inc.; Johns Hopkins University; Johnson Johnson; Kendeda Fund; Leslie Family Foundation; John D. and Catherine T. MacArthur Foundation; McKenna Foundation; Mid-Continent University; Monsanto Company; Mount Pleasant Lutheran Church; National Democratic Institute for International Affairs; OPEC Fund for International Development; Roman Catholic Diocese of Joliet; Government of Saudi Arabia; Saudi Fund for Development; JV Schiro Zavela Foundation; S.H.O.D. LLC; Stahl Family Foundation; St. Thomas Aquinas Parish; Sultanate of Oman: HH General Sheikh Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi, in honor of HH Sheikh Khalifa bin Zayed, President of the United Arab Emirates; UNICEF; UNICEF; United Kingdom Department for International Development; U.S. Agency for International Development; U.S. Centers for Disease Control and Prevention; United Nations World Food Programme; Vanguard Charitable Endowment Program; Vestergaard Frandsen; Women's Leadership Foundation; YKK Corporation; Wellcome Trust [098051] FX The Parasitic Diseases Branch, Division of Parasitic Diseases, CDC, serves as a WHO Collaborating Center on Dracunculiasis Eradication, and as such, received a small award from the NTD Department, WHO, in support of these activities. During 2008 2012, The Carter Center's work to eradicate Guinea worm disease has been made possible by financial and in-kind contributions from Next Generation Fund of the Hugh J. Andersen Foundation; Apple Computer, Inc.; Arab Fund for Economic and Social Development; Atlanta Woman's Club; BASF Corporation; Canadian International Development Agency; Chevron Corporation; Children's Investment Fund Foundation UK; Crawford Family Foundation; Delta Medical Supplies; Edgar O. Dixon Charitable Trust; Elfenworks Foundation; First Congregational Church;. Foundation Source; Bill & Melinda Gates Foundation; General Electric Company; Girl Scouts of America Brownie Troop 861; Global Aviation Holdings; Global Health Education Consortium, Inc.: Google, Inc.; Robert and Shirley Harris Family Foundation; Harris myCFO Foundation; Conrad N. Hilton Foundation; John C. and Karyl Kay Hughes Foundation; John P. Hussman Foundation, Inc.; Johns Hopkins University; Johnson & Johnson; Kendeda Fund; Leslie Family Foundation; John D. and Catherine T. MacArthur Foundation; McKenna Foundation; Mid-Continent University: Monsanto Company; Mount Pleasant Lutheran Church: National Democratic Institute for International Affairs: OPEC Fund for International Development; Roman Catholic Diocese of Joliet; Government of Saudi Arabia; Saudi Fund for Development; JV Schiro Zavela Foundation; S.H.O.D. LLC; Stahl Family Foundation; St. Thomas Aquinas Parish; Sultanate of Oman: HH General Sheikh Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi, in honor of HH Sheikh Khalifa bin Zayed, President of the United Arab Emirates; UNICEF; United Kingdom Department for International Development; U.S. Agency for International Development; U.S. Centers for Disease Control and Prevention; United Nations World Food Programme; Vanguard Charitable Endowment Program; Vestergaard Frandsen; Women's Leadership Foundation; YKK Corporation; and many generous individuals. The Wellcome Trust Sanger Institute is supported by the Wellcome Trust through grant 098051. NR 19 TC 24 Z9 24 U1 3 U2 31 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2014 VL 90 IS 1 BP 61 EP 70 DI 10.4269/ajtmh.13-0554 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 288BO UT WOS:000329587200012 PM 24277785 ER PT J AU Eddy, BA Blackstock, AJ Williamson, JM Addiss, DG Streit, TG de Rochars, VMB Fox, LM AF Eddy, Brittany A. Blackstock, Anna J. Williamson, John M. Addiss, David G. Streit, Thomas G. de Rochars, Valery M. Beau Fox, LeAnne M. TI A Longitudinal Analysis of the Effect of Mass Drug Administration on Acute Inflammatory Episodes and Disease Progression in Lymphedema Patients in Leogane, Haiti SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PREVENTING ACUTE ADENOLYMPHANGITIS; ELIMINATE LYMPHATIC FILARIASIS; BRUGIA-MALAYI INFECTION; PAPUA-NEW-GUINEA; BANCROFTIAN FILARIASIS; WUCHERERIA-BANCROFTI; AFFECTED-LIMB; DIETHYLCARBAMAZINE CHEMOTHERAPY; CLINICAL MANIFESTATIONS; COMPARATIVE EFFICACY AB We conducted a longitudinal analysis of 117 lymphedema patients in a filariasis-endemic area of Haiti during 1995-2008. No difference in lymphedema progression between those who received or did not receive mass drug administration (MDA) was found on measures of foot (P = 0.24), ankle (P = 0.87), or leg (P = 0.46) circumference; leg volume displacement (P = 0.09), lymphedema stage (P = 0.93), or frequency of adenolymphangitis (ADL) episodes (P = 0.57). Rates of ADL per year were greater after initiation of MDA among both groups (P < 0.01). Nevertheless, patients who received MDA reported improvement in four areas of lymphedema-related quality of life (P <= 0.01). Decreases in foot and ankle circumference and ADL episodes were observed during the 1995-1998 lymphedema management study (P <= 0.01). This study represents the first longitudinal, quantitative, leg-specific analysis examining the clinical effect of diethylcarbamazine on lymphedema progression and ADL episodes. C1 Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. Atlanta Res & Educ Fdn, Decatur, GA USA. [Addiss, David G.] Task Force Global Hlth, Children Worms, Decatur, GA USA. [Streit, Thomas G.] Univ Notre Dame, Ctr Trop Dis Res & Training, Notre Dame, IN 46556 USA. Hop St Croix, Lymphat Filariasis Program, Leogane, Haiti. [Eddy, Brittany A.] Partners Hlth, Boston, MA USA. [Blackstock, Anna J.; Fox, LeAnne M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Williamson, John M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Ctr Dis Control & Prevent, Kisian Kisumu, Kenya. [de Rochars, Valery M. Beau] Univ Florida, Dept Hlth Serv Res Management & Policy, Gainesville, FL USA. RP Fox, LM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A-06, Atlanta, GA 30333 USA. EM beddy@pih.org; ablackstock@cdc.gov; jwilliamson@ke.cdc.gov; daddiss@taskforce.org; streit1@nd.edu; madsenbeau@phhp.ufl.edu; lfox@cdc.gov FU University of Notre Dame Haiti Program; Bill and Melinda Gates Foundation; Fogarty International Center [5 R25 TW7733]; National Institutes of Health; Centers for Disease Control and Prevention FX This study was supported by The University of Notre Dame Haiti Program with funding by the Bill and Melinda Gates Foundation; the Framework in Global Health (grant 5 R25 TW7733) to Emory University from the Fogarty International Center, National Institutes of Health; and the Centers for Disease Control and Prevention. NR 52 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2014 VL 90 IS 1 BP 80 EP 88 DI 10.4269/ajtmh.13-0317 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 288BO UT WOS:000329587200015 PM 24218408 ER PT J AU Budge, PJ Dorkenoo, AM Sodahlon, YK Fasuyi, OB Mathieu, E AF Budge, Philip J. Dorkenoo, Ameyo M. Sodahlon, Yao K. Fasuyi, Omofolarin B. Mathieu, Els TI Ongoing Surveillance for Lymphatic Filariasis in Togo: Assessment of Alternatives and Nationwide Reassessment of Transmission Status SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SLEEPING-SICKNESS; BANCROFTIAN FILARIASIS; RAPID ASSESSMENT; MALARIA; ERADICATION; ELIMINATION; PROSPECTS; PROGRESS; LESSONS; STORY AB Tremendous progress has been made towards the goal of global elimination of lymphatic filariasis (LF) transmission by 2020. The number of endemic countries reducing LF transmission through mass drug administration continues to increase, and therefore, the need for effective post-intervention surveillance also continues to increase. Togo is the first sub-Saharan African country to implement LF surveillance, and it has 6 years of experience with this passive surveillance system. We herein report the results of a recent evaluation of the Togolese LF surveillance system, including an evaluation of blood donors as a surveillance population, and provide updated results of ongoing surveillance, including expansion in remote areas. Since implementation of LF surveillance in 2006, only three cases of positive Wuchereria bancrofti filaremia have been detected, suggesting that interruption of transmission has been sustained. Given the impracticality of validating the surveillance system in the absence of ongoing transmission, we confirmed the lack of transmission through a nationwide reassessment survey. C1 Ctr Dis Control & Prevent, Epidem Intelligence Serv Assigned Parasit Dis Bra, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Dorkenoo, Ameyo M.] Minist Hlth, Program Eliminat Lymphat Filariasis, Lome, Togo. Mectizan Donat Program, Atlanta, GA USA. Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Budge, Philip J.] Vanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA. [Sodahlon, Yao K.] Mectizan Donat Program, Decatur, GA USA. [Fasuyi, Omofolarin B.] Morehouse Sch Med, Dept Family Med, East Point, GA USA. [Mathieu, Els] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. RP Mathieu, E (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM Philip.budge@vanderbilt.edu; monicadork@yahoo.fr; ysodahlon@taskforce.org; OFasuyi@msm.edu; emm7@cdc.gov FU U.S. Agency for International Development (USAID); ENVISION [AID-OAA-A-11-00048] FX This study is made possible by the generous support of the American people through the U.S. Agency for International Development (USAID) and the ENVISION project under cooperative agreement No. AID-OAA-A-11-00048. NR 25 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2014 VL 90 IS 1 BP 89 EP 95 DI 10.4269/ajtmh.13-0407 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 288BO UT WOS:000329587200016 PM 24189363 ER PT J AU Lindsey, NP Staples, JE Delorey, MJ Fischer, M AF Lindsey, Nicole P. Staples, J. Erin Delorey, Mark J. Fischer, Marc TI Lack of Evidence of Increased West Nile Virus Disease Severity in the United States in 2012 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RISK-FACTORS; ARBOVIRAL DISEASES; INFECTION; ENCEPHALITIS; OUTBREAK; EPIDEMIC; COLORADO; REGION; USA AB In the United States, West Nile virus (WNV) causes annual seasonal outbreaks that fluctuate in size and scope. There was a large multistate outbreak of WNV in 2012, with more human disease cases reported nationally than any year since 2003. We evaluated national surveillance data to determine if the higher number of WNV cases reported in 2012 was associated with changes in the epidemiology or severity of disease compared with 2004-2011. Despite an increased incidence of neuroinvasive disease in 2012, national surveillance data showed no evidence of changes in epidemiology or increased disease severity compared with the previous 8 years. C1 [Lindsey, Nicole P.; Staples, J. Erin; Delorey, Mark J.; Fischer, Marc] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Lindsey, NP (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM frd3@cdc.gov; auv1@cdc.gov; esy7@cdc.gov; mxf2@cdc.gov FU Centers for Disease Control and Prevention FX This work was funded by the Centers for Disease Control and Prevention. NR 23 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2014 VL 90 IS 1 BP 163 EP 168 DI 10.4269/ajtmh.13-0432 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 288BO UT WOS:000329587200029 PM 24218412 ER PT J AU Bamrah, S Desmond, E Ghosh, S France, AM Kammerer, JS Cowan, LS Heetderks, A Forbes, A Moonan, PK AF Bamrah, Sapna Desmond, Edward Ghosh, Smita France, Anne Marie Kammerer, J. Steve Cowan, Lauren S. Heetderks, Andrew Forbes, Alstead Moonan, Patrick K. TI Molecular Epidemiology of Mycobacterium tuberculosis in the United States-Affiliated Pacific Islands SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH LA English DT Article DE genotype; molecular epidemiology; Pacific Islands (trust territory); tuberculosis ID MULTIDRUG-RESISTANT TUBERCULOSIS; DIAGNOSIS; OUTBREAK AB The United States-Affiliated Pacific Islands (USAPI) are part of the US National Tuberculosis (TB) Surveillance System and use laboratory services contracted through a cooperative agreement with the Centers for Disease Control and Prevention (CDC). In 2004, the CDC established the National Tuberculosis Genotyping Service, a system to genotype 1 isolate from each culture-confirmed case of TB. To describe the molecular epidemiology of TB in the region, we examined all Mycobacterium tuberculosis isolates submitted for genotyping from January 1, 2004, to December 31, 2008. Over this time period, the USAPI jurisdictions reported 1339 verified TB cases to the National Tuberculosis Surveillance System. Among 419 (31%) reported culture-confirmed TB cases, 352 (84%) had complete genotype results. Routine TB genotyping allowed, for the first time, an exploration of the molecular epidemiology of TB in the USAPI. C1 [Bamrah, Sapna; Ghosh, Smita; France, Anne Marie; Kammerer, J. Steve; Cowan, Lauren S.; Heetderks, Andrew; Forbes, Alstead; Moonan, Patrick K.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Desmond, Edward] State Calif Dept Publ Hlth Labs, Richmond, CA USA. RP Bamrah, S (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, 1600 Clifton Rd,Mailstop E-10, Atlanta, GA 30333 USA. EM sbamrah@cdc.gov RI Moonan, Patrick/F-4307-2014; OI Moonan, Patrick/0000-0002-3550-2065 NR 19 TC 0 Z9 0 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1010-5395 EI 1941-2479 J9 ASIA-PAC J PUBLIC HE JI Asia-Pac. J. Public Health PD JAN PY 2014 VL 26 IS 1 BP 77 EP 84 DI 10.1177/1010539512469249 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 287MF UT WOS:000329545200011 PM 23239749 ER PT J AU Schrader, SM Marlow, KL AF Schrader, Steven M. Marlow, Katherine L. TI Assessing the reproductive health of men with occupational exposures SO ASIAN JOURNAL OF ANDROLOGY LA English DT Review DE accessory glands; endocrine; epidemiology; semen; sexual function; sperm; testis; toxicology ID IN-SITU HYBRIDIZATION; MALE SEXUAL FUNCTION; NOCTURNAL PENILE TUMESCENCE; SPERM CHROMATIN-STRUCTURE; MALE HORMONE PROFILE; SEMEN QUALITY; LEAD-EXPOSURE; INHIBIN-B; AGRICULTURAL-WORKERS; REGIONAL DIFFERENCES AB The earliest report linking environmental (occupational) exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane (DBCP) on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. Many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined. C1 [Schrader, Steven M.] NIOSH, Ctr Dis Control, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Schrader, Steven M.] NIOSH, Ctr Prevent, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Schrader, SM (reprint author), NIOSH, Ctr Dis Control, Div Appl Res & Technol, Cincinnati, OH 45226 USA. EM sms4@cdc.gov NR 128 TC 2 Z9 2 U1 4 U2 17 PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 1008-682X EI 1745-7262 J9 ASIAN J ANDROL JI Asian J. Androl. PD JAN PY 2014 VL 16 IS 1 BP 23 EP 30 DI 10.4103/1008-682X.122352 PG 8 WC Andrology; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA 285QW UT WOS:000329409700004 PM 24369130 ER PT J AU Kelly, NR Harding, JT Fulton, JE Kozinetz, CA AF Kelly, N. R. Harding, J. T. Fulton, J. E. Kozinetz, C. A. TI A randomized controlled trial of a video module to increase US poison center use by low-income parents SO CLINICAL TOXICOLOGY LA English DT Article DE Poison prevention; Educational intervention; Community outreach ID EXPOSURES; BARRIERS; CHILDREN; ASSOCIATION; VISITS; SYSTEM; TEXAS AB Context. U.S. poison centers decrease medical visits by providing telephone advice for home management of potential poisonings, but are underutilized by low-income African-American and Latino parents, and those with limited English proficiency, due to lack of knowledge and misconceptions about poison centers. Objectives. To assess the effectiveness of a poison prevention video module in improving knowledge, behavior, and behavioral intention concerning use of poison centers in a population of low-income, language-diverse adults attending parenting courses offered by a community organization. Methods. A randomized, blinded, controlled trial was conducted at 16 parenting course sites of a community organization and included 297 participants. The organization's instructors presented the video module (intervention) or the usual class curriculum (control). Participants completed questionnaires at baseline and a telephone interview 2-4 weeks later. Changes from baseline to follow-up were compared between the intervention and control groups using analysis of variance and Chi-square tests. Intervention group participants were stratified by English proficiency and compared to assess baseline and follow-up responses by language. Results. After the intervention, participants in the intervention group had a significantly greater increase in knowledge about the poison center, were more likely to have the correct poison center phone number at home, and had greater behavioral intention to use the poison center compared to control group participants. At baseline, Spanish-primary-language participants with limited English proficiency had less knowledge about the poison center, were less likely to have the poison center number at home, and had lower behavioral intention to use the poison center than English proficient participants, but significantly improved after the intervention. Conclusions. This video module, when presented by a community organization's instructors, was highly effective in improving knowledge, behavior, and behavioral intention concerning use of poison centers within a low-income, language-diverse population. C1 [Kelly, N. R.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA. [Harding, J. T.] DePelchin Childrens Ctr, Houston, TX USA. [Fulton, J. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kozinetz, C. A.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. RP Kelly, NR (reprint author), Childrens Med Ctr, 1935 Med Dist Dr, Dallas, TX 75235 USA. EM Nancy.Kelly@childrens.com FU Charlotte and Jamil Azzam Foundation FX This study was funded by the Charlotte and Jamil Azzam Foundation. NR 20 TC 0 Z9 0 U1 0 U2 4 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 EI 1556-9519 J9 CLIN TOXICOL JI Clin. Toxicol. PD JAN PY 2014 VL 52 IS 1 BP 54 EP 62 DI 10.3109/15563650.2013.863328 PG 9 WC Toxicology SC Toxicology GA 286XF UT WOS:000329501900009 PM 24299276 ER PT J AU Krahn, GL Reyes, M Fox, M AF Krahn, Gloria L. Reyes, Michele Fox, Michael TI Toward a conceptual model for national policy and practice considerations SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Chronic conditions; Chronic disease; Disability; National ID PHYSICAL-DISABILITIES; HEALTH DISPARITIES; UNITED-STATES; ADULTS; LIFE AB Chronic diseases and conditions are serious threats to the population's health. Chronic diseases represent seven of the top ten causes of mortality in the U. S. and are major economic drivers underlying burgeoning national health costs. People with disabilities experience dramatically higher rates of some chronic conditions, but only recently has this problem been recognized. We propose a set of contributing factors and a model to help better understand the relationship of disability with chronic disease. The paper summarizes current CDC initiatives to include disability status and considerations in public health surveys and programs, exemplifying a strategy to promote inclusion of people with disabilities in mainstream programs wherever possible; use cross-disability strategies for conditions unique to people with disabilities where necessary; and implement condition-specific approaches where essential. This initial model is intended to invite dialog on a conceptual framework for preventing chronic conditions and additional functional limitations among people with disabilities. Published by Elsevier Inc. C1 [Krahn, Gloria L.; Reyes, Michele; Fox, Michael] Ctr Dis Control & Prevent, Div Human Dev & Disabil, Atlanta, GA USA. RP Krahn, GL (reprint author), 1600 Clifton Rd NE,MS E88, Atlanta, GA 30333 USA. EM gfk2@cdc.gov FU Intramural CDC HHS [CC999999] NR 32 TC 11 Z9 11 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 EI 1876-7583 J9 DISABIL HEALTH J JI Disabil. Health J. PD JAN PY 2014 VL 7 IS 1 BP 13 EP 18 DI 10.1016/j.dhjo.2013.06.006 PG 6 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA 286VT UT WOS:000329498100004 PM 24411502 ER PT J AU Pinney, SM Biro, FM Windham, GC Herrick, RL Yaghjyan, L Calafat, AM Succop, P Sucharew, H Ball, KM Kato, K Kushi, LH Bornschein, R AF Pinney, Susan M. Biro, Frank M. Windham, Gayle C. Herrick, Robert L. Yaghjyan, Lusine Calafat, Antonia M. Succop, Paul Sucharew, Heidi Ball, Kathleen M. Kato, Kayoko Kushi, Lawrence H. Bornschein, Robert TI Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA SO ENVIRONMENTAL POLLUTION LA English DT Article DE Polyfluoroalkyl compounds (PFCs); Human milk; Biomonitoring; Drinking water contaminants; Children ID PERFLUOROOCTANOIC ACID PFOA; PERFLUORINATED COMPOUNDS; NATIONAL-HEALTH; DRINKING-WATER; PERFLUOROALKYL COMPOUNDS; NHANES 1999-2000; HUMAN-MILK; CHEMICALS; POPULATION; SUBSTANCES AB PFC serum concentrations were measured in 6-8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12-19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Pinney, Susan M.; Herrick, Robert L.; Succop, Paul; Bornschein, Robert] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Biro, Frank M.] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229 USA. [Biro, Frank M.; Sucharew, Heidi; Ball, Kathleen M.] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA. [Windham, Gayle C.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA 94804 USA. [Yaghjyan, Lusine] Washington Univ, St Louis, MO 63110 USA. [Calafat, Antonia M.; Kato, Kayoko] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Kushi, Lawrence H.] Kaiser Permanente, Div Res, Oakland, CA 94612 USA. RP Pinney, SM (reprint author), Univ Cincinnati, Coll Med, Dept Environm Hlth, POB 670056, Cincinnati, OH 45267 USA. EM susan.pinney@uc.edu; frank.biro@cchmc.org; gayle.windham@cdph.ca.gov; herricrl@mail.uc.edu; yaghjyanl@wudosis.wustl.edu; aic7@cdc.gov; paul.succop@uc.edu; heidi.sucharew@cchmc.org; Kathleen.ball@cchmc.org; kayoko.kato@cdc.hhs.gov; larry.kushi@kp.org; Robert.bornschein@uc.edu RI Sucharew, Heidi/M-4338-2015; OI Kushi, Lawrence/0000-0001-9136-1175 FU National Institute of Environmental Health Sciences; National Cancer Institute [U01 ES12770, U01 ES019453, U01 ES019457]; University of California [U01ES012801, U01ES019435, U01ES019457]; University of Cincinnati Center for Environmental Genetics [P30-ES06096]; Molecular Epidemiology in Children's Environmental Health [T32ES010957]; NCRR [CTSA-Ul1RR026314, UL1RR024131] FX Support for this project provided by the National Institute of Environmental Health Sciences and the National Cancer Institute to the University of Cincinnati/Cincinnati Children's Hospital Medical Center, (U01 ES12770, U01 ES019453, U01 ES019457), the University of California (U01ES012801, U01ES019435 and U01ES019457), the University of Cincinnati Center for Environmental Genetics (P30-ES06096), and Molecular Epidemiology in Children's Environmental Health (T32ES010957), CTSA-Ul1RR026314 and UL1RR024131 from NCRR. We are grateful to Amanda Kolb, Anita Southwick, Cendi Dahl and Anoush Mirabedi for study coordination, Dr. Patrick Ryan for geocoding assistance, Dr. Aimin Chen for his insightful review, and to Charles Dodson, Dr. Zsuzsanna Kuklenyik, Xavier Bryant, Amal Wanigatunga, Brian Basden, Tao Jia and Dr. Jack Reidy for the PFC measures in serum, Justin Bates for data management and Veronica Ratliff for editorial assistance and to the Greater Cincinnati and San Francisco Bay area breast cancer advocates for observations, input and support. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the Centers for Disease Control and Prevention. NR 49 TC 14 Z9 15 U1 1 U2 36 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD JAN PY 2014 VL 184 SI SI BP 327 EP 334 DI 10.1016/j.envpol.2013.09.008 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 285TZ UT WOS:000329419200040 PM 24095703 ER PT B AU Hess, JJ Marinucci, G Schramm, PJ Manangan, A Luber, G AF Hess, Jeremy J. Marinucci, Gino Schramm, Paul J. Manangan, Arie Luber, George BE Pinkerton, KE Rom, WN TI Management of Climate Change Adaptation at the United States Centers for Disease Control and Prevention SO GLOBAL CLIMATE CHANGE AND PUBLIC HEALTH SE Respiratory Medicine Series LA English DT Article; Book Chapter DE Climate change and the CDC; CDC policies on climate change adaptation; Public health policy on climate change; Climate change adaptation and public policy; Climate and Health Program ID PUBLIC-HEALTH INTERVENTIONS; COMPARATIVE RISK-ASSESSMENT; HEAT-RELATED MORTALITY; ADAPTIVE MANAGEMENT; POLICY AB As the nation's public health agency, CDC recognizes that climate change poses a multifaceted and potentially significant threat to domestic public health. To facilitate climate change preparedness in public health, the agency developed the Climate and Health Program, which is housed in the National Center for Environmental Health. The Program's mission is to translate science for public health partners, develop decision support tools to facilitate climate change adaptation in public health, and to serve as a credible leader in planning for the human health impacts of a changing climate. Since its formation, the Program has worked to articulate a public health approach to climate change and integrate science from public health and other sectors to facilitate public health adaptation efforts. The Program has developed an adaptive management framework for public health, the BRACE framework, and is working cooperatively with several state and local health departments to pursue an evidence-based approach to climate change adaptation. As public health's expertise and experience grows, the Climate and Health Program will work to continue disseminating relevant information for the increasing number of public health practitioners focused on reducing the adverse health effects of climate change. C1 [Hess, Jeremy J.] Emory Sch Med & Publ Hlth, Atlanta, GA USA. [Hess, Jeremy J.] CDC, Climate & Hlth Program, NCEH, Atlanta, GA 30333 USA. [Marinucci, Gino; Schramm, Paul J.; Manangan, Arie; Luber, George] Ctr Dis Control & Prevent, Climate & Hlth Program, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Hess, JJ (reprint author), Emory Sch Med & Publ Hlth, Atlanta, GA USA. EM jhess@emory.edu NR 33 TC 3 Z9 3 U1 1 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-4614-8417-2; 978-1-4614-8416-5 J9 RESPIR MED SER PY 2014 VL 7 BP 341 EP 360 DI 10.1007/978-1-4614-8417-2_20 D2 10.1007/978-1-4614-8417-2 PG 20 WC Environmental Sciences; Public, Environmental & Occupational Health; Respiratory System SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Respiratory System GA BJJ05 UT WOS:000328380700021 ER PT J AU Liu, Y Croft, JB Anderson, LA Wheaton, AG Presley-Cantrell, LR Ford, ES AF Liu, Yong Croft, Janet B. Anderson, Lynda A. Wheaton, Anne G. Presley-Cantrell, Letitia R. Ford, Earl S. TI The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994-2006 SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE chronic obstructive pulmonary disease; mortality; activities of daily living; instrumental activities of daily living; disability ID AIR-FLOW OBSTRUCTION; ELDERLY-PEOPLE; UNITED-STATES; PHYSICAL-ACTIVITY; COMMUNITY; HEALTH; COPD; SUPPORT; ADL; LONELINESS AB Purpose: To assess associations among chronic obstructive pulmonary disease (COPD), disability as measured by activities of daily living (ADL) and instrumental ADL (IADL), engagement in social activities, and death among elderly noninstitutionalized US residents. Materials and methods: A nationally representative sample of 9,415 adults who were aged >70 years and responded to the Second Supplement on Aging survey in 1994-1996 and mortality follow-up study through 2006 were assessed. Multiple logistic regression analyses were performed to assess the risk of all-cause mortality in participants with COPD after accounting for age, sex, race/ethnicity, and smoking status. Results: At baseline, approximately 9.6% of study participants reported having COPD. Compared with participants without COPD, those with COPD were significantly more likely (P<0.05) to have difficulty with at least one ADL (44.3% versus [vs] 27.5%) and with at least one IADL (59.9% vs 40.2%), significantly less likely to be engaged in social activities (32.6% vs 26.3%), and significantly more likely to die by 2006 (70.7% vs 60.4%; adjusted risk ratio 1.15, P<0.05). The association between COPD and risk for death was moderately attenuated by disability status. Conclusion: COPD is positively associated with disability and mortality risk among US adults aged >= 70 years. The significant relationship between COPD and mortality risk was moderately attenuated, but was not completely explained by stages of ADL and IADL limitations and social activities. C1 [Liu, Yong; Croft, Janet B.; Wheaton, Anne G.; Ford, Earl S.] Emory Univ, Epidemiol & Surveillance Branch, Atlanta, GA 30322 USA. [Anderson, Lynda A.] Emory Univ, Hlth Aging Program, Div Populat Hlth, CDC, Atlanta, GA 30322 USA. [Anderson, Lynda A.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Presley-Cantrell, Letitia R.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Program Dev & Serv Management, Atlanta, GA USA. RP Liu, Y (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, 4770 Buford Highway Northeast,Mailstop F-78, Atlanta, GA 30341 USA. EM ikd8@cdc.gov NR 46 TC 11 Z9 11 U1 3 U2 10 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1176-9106 EI 1178-2005 J9 INT J CHRONIC OBSTR JI Int. J. Chronic Obstr. Pulm. Dis. PY 2014 VL 9 BP 75 EP 83 DI 10.2147/COPD.S53676 PG 9 WC Respiratory System SC Respiratory System GA 290ZX UT WOS:000329798400001 PM 24477269 ER PT J AU Holman, DM Benard, V Roland, KB Watson, M Liddon, N Stokley, S AF Holman, Dawn M. Benard, Vicki Roland, Katherine B. Watson, Meg Liddon, Nicole Stokley, Shannon TI Barriers to Human Papillomavirus Vaccination Among US Adolescents A Systematic Review of the Literature SO JAMA PEDIATRICS LA English DT Review ID NUTRITION EXAMINATION SURVEY; IMMUNIZATION SURVEY-TEEN; STATES-NATIONAL-HEALTH; ETHNIC-MINORITY GIRLS; AGED 13-17 YEARS; HPV VACCINE; UNITED-STATES; AFRICAN-AMERICAN; CERVICAL-CANCER; PUBLIC-HEALTH AB IMPORTANCE Since licensure of the human papillomavirus (HPV) vaccine in 2006, HPV vaccine coverage among US adolescents has increased but remains low compared with other recommended vaccines. OBJECTIVE To systematically review the literature on barriers to HPV vaccination among US adolescents to inform future efforts to increase HPV vaccine coverage. EVIDENCE REVIEW We searched PubMed and previous review articles to identify original research articles describing barriers to HPV vaccine initiation and completion among US adolescents. Only articles reporting data collected in 2009 or later were included. Findings from 55 relevant articles were summarized by target populations: health care professionals, parents, underserved and disadvantaged populations, and males. FINDINGS Health care professionals cited financial concerns and parental attitudes and concerns as barriers to providing the HPV vaccine to patients. Parents often reported needing more information before vaccinating their children. Concerns about the vaccine's effect on sexual behavior, low perceived risk of HPV infection, social influences, irregular preventive care, and vaccine cost were also identified as potential barriers among parents. Some parents of sons reported not vaccinating their sons because of the perceived lack of direct benefit. Parents consistently cited health care professional recommendations as one of the most important factors in their decision to vaccinate their children. CONCLUSIONS AND RELEVANCE Continued efforts are needed to ensure that health care professionals and parents understand the importance of vaccinating adolescents before they become sexually active. Health care professionals may benefit from guidance on communicating HPV recommendations to patients and parents. Further efforts are also needed to reduce missed opportunities for HPV vaccination when adolescents interface with the health care system. Efforts to increase uptake should take into account the specific needs of subgroups within the population. Efforts that address system-level barriers to vaccination may help to increase overall HPV vaccine uptake. C1 [Holman, Dawn M.; Benard, Vicki; Roland, Katherine B.; Watson, Meg] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Liddon, Nicole] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30341 USA. [Stokley, Shannon] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30341 USA. RP Holman, DM (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy NE,Mailstop F-76, Atlanta, GA 30341 USA. EM dholman@cdc.gov FU Intramural CDC HHS [CC999999] NR 84 TC 155 Z9 156 U1 8 U2 46 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD JAN PY 2014 VL 168 IS 1 BP 76 EP 82 DI 10.1001/jamapediatrics.2013.2752 PG 7 WC Pediatrics SC Pediatrics GA 291RK UT WOS:000329846600016 PM 24276343 ER PT J AU Moreno, MA AF Moreno, Megan A. TI Phthalate Exposure and Health Risks SO JAMA PEDIATRICS LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Moreno, MA (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 1 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD JAN PY 2014 VL 168 IS 1 BP 96 EP 96 PG 1 WC Pediatrics SC Pediatrics GA 291RK UT WOS:000329846600019 PM 24394978 ER PT J AU Zhou, XL Kramer, JP Calafat, AM Ye, XY AF Zhou, Xiaoliu Kramer, Joshua P. Calafat, Antonia M. Ye, Xiaoyun TI Automated on-line column-switching high performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of bisphenol A, bisphenol F, bisphenol S, and 11 other phenols in urine SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Bisphenol A; Bisphenol F; Bisphenol S; Exposure; HPLC-MS/MS; Urine ID EXTRACTION AB Human exposure to bisphenol A (BPA) is widespread. However, in recent years, bisphenol analogs such as bisphenol S (BPS) and bisphenol F (BPF) are replacing BPA in the production of some consumer products. Because human exposure to these alternative bisphenols may occur, biomonitoring of these bisphenol analogs is warranted. In the present study, we developed and validated a sensitive and selective method that uses on-line solid phase extraction coupled to high performance liquid chromatography-isotope dilution tandem mass spectrometry with peak focusing to measure BPA, BPF, BPS, and 11 other environmental phenols in urine. The method required a small amount of sample (100 ILL) and minimal sample pretreatment. The limits of detection were 0.03 ng/mL (BPS), 0.06 ng/mL (BPF), 0.10 ng/mL (BPA), and ranged from 0.1 ng/mL to 1.0 ng/mL for the other 11 phenols. In 100 urine samples collected in 2009-2012 from a convenience group of anonymous adults in the United States, of the three bisphenols, we detected BPA at the highest frequency and median concentrations (95%, 0.72 ng/mL), followed by BPS (78%, 0.13 ng/mL) and BPF (55%, 0.08 ng/mL). This sensitive, rugged, and labor and cost-effective method could be used for the analysis of large number of samples for epidemiologic studies. Published by Elsevier B.V. C1 [Zhou, Xiaoliu; Kramer, Joshua P.; Calafat, Antonia M.; Ye, Xiaoyun] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. RP Ye, XY (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy,Mailstop F53, Atlanta, GA 30341 USA. EM xay5@cdc.gov FU U.S. Department of Energy; CDC FX This work was supported in part by an appointment (Joshua P. Kramer) to the Research Participation Program at the Centers for Disease Control and Prevention (CDC), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 21 TC 47 Z9 48 U1 7 U2 111 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 EI 1873-376X J9 J CHROMATOGR B JI J. Chromatogr. B PD JAN 1 PY 2014 VL 944 BP 152 EP 156 DI 10.1016/j.jchromb.2013.11.009 PG 5 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 290PH UT WOS:000329770300025 PM 24316527 ER PT J AU Kaddumukasa, MA Mutebi, JP Lutwama, JJ Masembe, C Akol, AM AF Kaddumukasa, M. A. Mutebi, J. -P. Lutwama, J. J. Masembe, C. Akol, A. M. TI Mosquitoes of Zika Forest, Uganda: Species Composition and Relative Abundance SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Zika forest; Uganda; mosquito species composition; arbovirus vector ID ONYONG-NYONG FEVER; SOUTH-CENTRAL UGANDA; YELLOW-FEVER; EPIDEMIC; VIRUS; EMERGENCE; DIPTERA; MONKEYS; ABSENCE AB Mosquito collections were conducted in Zika Forest near Entebbe, Uganda, from July 2009 through June 2010 using CO2-baited light traps, ovitraps, and human-baited catches. In total, 163,790 adult mosquitoes belonging to 12 genera and 58 species were captured. Of these, 22 species (38%) were captured in Zika Forest for the first time. All the new records found in the forest in this study had previously been captured in other regions of Uganda, implying that they are native to the country and do not represent new introductions. More than 20 species previously collected in Zika Forest were not detected in our collections, and this may suggest a change in the mosquito fauna during the past 40 yr or variation in species composition from year to year. Arboviruses of public health importance have previously been isolated from >50% of the 58 mosquito species captured in Zika Forest, which suggests a high potential for transmission and maintenance of a wide range of arboviruses in Zika Forest. C1 [Kaddumukasa, M. A.; Masembe, C.; Akol, A. M.] Makerere Univ, Dept Biol Sci, Coll Nat Sci, Kampala, Uganda. [Kaddumukasa, M. A.; Lutwama, J. J.] Uganda Virus Res Inst, Dept Arbovirol, Entebbe, Uganda. [Mutebi, J. -P.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP Akol, AM (reprint author), Makerere Univ, Dept Biol Sci, Coll Nat Sci, POB 7062, Kampala, Uganda. EM aakol@sci.mak.ac.ug FU Uganda Virus Research Institute; Department of Biological Sciences, Makerere University; UVRIE; CDC; Organization for Women in Science for the Developing World (OWSDW) FX We thank F. Ssenfuka, T. Muwawu, J.-F. Lwanga, J. Mugga, and S. Wakaalo for their assistance in the field and in the laboratory. We thank R. Kading and M. Crabtree of the Centers for Disease Control and Prevention (CDC) and the entomology team at Kenya Medical Research Institute (KEMRI), Nairobi, for their assistance with mosquito identification. We thank the Uganda Virus Research Institute and the Department of Biological Sciences, Makerere University, for financial assistance. This research was partly funded by in part by UVRIE, the CDC and by a grant from the Organization for Women in Science for the Developing World (OWSDW) formerly TWOWS to M. Kaddumukasa. NR 45 TC 5 Z9 6 U1 1 U2 24 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2014 VL 51 IS 1 BP 104 EP 113 DI 10.1603/ME12269 PG 10 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 291CF UT WOS:000329804600012 PM 24605459 ER PT J AU Barrera, R Amador, M Acevedo, V Caban, B Felix, G Mackay, AJ AF Barrera, Roberto Amador, Manuel Acevedo, Veronica Caban, Belkis Felix, Gilberto Mackay, Andrew J. TI Use of the CDC Autocidal Gravid Ovitrap to Control and Prevent Outbreaks of Aedes aegypti (Diptera: Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; vector control; mosquito trap; dengue; outbreak ID LETHAL OVITRAP; DENGUE VECTORS; BG-SENTINEL; FIELD PERFORMANCE; NORTH QUEENSLAND; STICKY OVITRAPS; MALE MOSQUITOS; POPULATION; AUSTRALIA; ADULT AB Populations of Aedes aegypti (L.) can be managed through reductions in adult mosquito survival, number of offspring produced, or both. Direct adult mortality can be caused by the use of space sprays or residual insecticides to mosquito resting sites, and with a variety of residual insecticide-impregnated surfaces that are being tested, such as curtains, covers for water-storage vessels, bednets, and ovitraps. The fertility of Ae. aegypti populations can be reduced by the use of autocidal oviposition cups that prevent the development of mosquitoes inside the trap by mechanical means or larvicides, as well as by releasing sterile, transgenic, and para-transgenic mosquitoes. Survival and fertility can be simultaneously reduced by capturing gravid female Ae. aegypti with sticky gravid traps. We tested the effectiveness of the novel Centers for Disease Control and Prevention autocidal gravid ovitrap (CDC-AGO trap) to control natural populations of Ae. aegypti under field conditions in two isolated urban areas (reference vs. intervention areas) in southern Puerto Rico for 1 yr. There were significant reductions in the captures of female Ae. aegypti ( 53D70%) in the intervention area. The presence of three to four AGO control traps per home in 81% of the houses prevented outbreaks of Ae. aegypti, which would be expected after rains. Mosquito captures in BG-Sentinel and AGO traps were significantly and positively correlated, showing that AGO traps are useful and inexpensive mosquito surveillance devices. The use of AGO traps to manage Ae. aegypti populations is compatible with other control means such as source reduction, larviciding, adulticiding, sterile insect techniques, induced cytoplasmic incompatibility, and dominant lethal gene systems. C1 [Barrera, Roberto; Amador, Manuel; Acevedo, Veronica; Caban, Belkis; Felix, Gilberto; Mackay, Andrew J.] Ctr Dis Control & Prevent, Entomol & Ecol Act, Dengue Branch, San Juan, PR 00920 USA. RP Barrera, R (reprint author), Ctr Dis Control & Prevent, Entomol & Ecol Act, Dengue Branch, 1324 Calle Canada, San Juan, PR 00920 USA. EM rbarrera@cdc.gov FU Intramural CDC HHS [CC999999] NR 37 TC 22 Z9 22 U1 4 U2 29 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2014 VL 51 IS 1 BP 145 EP 154 DI 10.1603/ME13096 PG 10 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 291CF UT WOS:000329804600017 PM 24605464 ER PT J AU Lutomiah, J Musila, L Makio, A Ochieng, C Koka, H Chepkorir, E Mutisya, J Mulwa, F Khamadi, S Miller, BR Bast, J Schnabel, D Wurapa, EK Sang, R AF Lutomiah, Joel Musila, Lillian Makio, Albina Ochieng, Caroline Koka, Hellen Chepkorir, Edith Mutisya, James Mulwa, Francis Khamadi, Samoel Miller, Barry R. Bast, Joshua Schnabel, David Wurapa, Eyako K. Sang, Rosemary TI Ticks and Tick-Borne Viruses From Livestock Hosts in Arid and Semiarid Regions of the Eastern and Northeastern Parts of Kenya SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Kenya; tick; arbovirus; surveillance; semiarid ID CONGO HEMORRHAGIC-FEVER; NAIROBI SHEEP DISEASE; IXODID TICKS; DHORI VIRUS; FAMILY BUNYAVIRIDAE; GENUS NAIROVIRUS; IJARA DISTRICT; RT-PCR; AFRICA; DUGBE AB Biodiversity and relative abundance of ticks and associated arboviruses in Garissa (northeastern) and Isiolo (eastern) provinces of Kenya were evaluated. Ticks were collected from livestock, identified to species, pooled, and processed for virus isolation. In Garissa, Rhipicephalus pulchellus Gerstacker (57.8%) and Hyalomma truncatum Koch (27.8%) were the most abundant species sampled, whereas R. pulchellus (80.4%) and Amblyomma gemma Donitz (9.6%) were the most abundant in Isiolo. Forty-four virus isolates, comprising Dugbe virus (DUGV; n = 22) and Kupe virus (n = 10; Bunyaviridae: Nirovirus), Dhori virus (DHOV; n = 10; Orthomyxoviridae: Thogotovirus), and Ngari virus (NRIV; n = 2; Bunyaviridae: Orthobunyavirus), were recovered mostly from R. pulchellus sampled in Isiolo. DUGV was mostly recovered from R. pulchellus from sheep and cattle, and DHOV from R. pulchellus from sheep. All Kupe virus isolates were from Isiolo ticks, including R. pulchellus from all the livestock, A. gemma and Amblyomma variegatum F. from cattle, and H. truncatum from goat. NRIV was obtained from R. pulchellus and A. gemma sampled from cattle in Isiolo and Garissa, respectively, while all DHOV and most DUGV (n = 12) were from R. pulchellus sampled from cattle in Garissa. DUGV was also recovered from H. truncatum and Amblyomma hebraeum Koch from cattle and from Rhipicephalus annulatus Say from camel. This surveillance study has demonstrated the circulation of select tick-borne viruses in parts of eastern and northeastern provinces of Kenya, some of which are of public health importance. The isolation of NRIV from ticks is particularly significant because it is usually known to be a mosquito-borne virus affecting humans. C1 [Lutomiah, Joel; Sang, Rosemary] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi 00100, Kenya. [Lutomiah, Joel; Musila, Lillian; Makio, Albina; Ochieng, Caroline; Koka, Hellen; Mutisya, James; Khamadi, Samoel; Wurapa, Eyako K.; Sang, Rosemary] US Army Med Res Unit, Div Emerging Infect Dis, Nairobi 00621, Kenya. [Chepkorir, Edith; Mulwa, Francis] Int Ctr Insect Physiol & Ecol, Nairobi 00100, Kenya. [Miller, Barry R.] Ctr Dis Control & Prevent, US Dept HHS, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Bast, Joshua] US Army Med Res Unit, Dept Entomol, Kisumu 40100, Kenya. [Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Lutomiah, J (reprint author), Kenya Govt Med Res Ctr, Ctr Virus Res, POB 54628, Nairobi 00100, Kenya. EM joel.lutomiah@usamru-k.org FU Department of Emerging Infectious Diseases (DEID); USAMRU-K; AFHSC; Global Disease Detection (GDD), CDC FX We thank Dunstone Beti, John Gachoya, Reuben Lugalia, and Anthony Mutai for their expert contribution in tick sampling and identification. We also acknowledge Santos Yalwala for drawing the site map. This project was supported by the Department of Emerging Infectious Diseases (DEID), USAMRU-K, AFHSC, and the Global Disease Detection (GDD), CDC. The content is solely the views of the authors and does not represent the official views of AFHSC or GDD. NR 50 TC 5 Z9 5 U1 2 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2014 VL 51 IS 1 BP 269 EP 277 DI 10.1603/ME13039 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 291CF UT WOS:000329804600031 PM 24605478 ER PT J AU Calfee, MW Rose, LJ Tufts, J Morse, S Clayton, M Touati, A Griffin-Gatchalian, N Slone, C McSweeney, N AF Calfee, M. Worth Rose, Laura J. Tufts, Jenia Morse, Stephen Clayton, Matt Touati, Abderrahmane Griffin-Gatchalian, Nicole Slone, Christina McSweeney, Neal TI Evaluation of sampling methods for Bacillus spore-contaminated HVAC filters SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE HVAC sampling; Anthrax; Bacillus anthracis; biological agent; bioterror ID NONPOROUS SURFACES; VENTILATION DUCTS; FLUIDIZED SPORES; COLLECTION; DEPOSITION; RELEASE; DECONTAMINATION; BIOTERRORISM; INFILTRATION; BUILDINGS AB The objective of this study was to compare an extraction-based sampling method to two vacuum-based sampling methods (vacuum sock and 37 mm cassette filter) with regards to their ability to recover Bacillus atrophaeus spores (surrogate for Bacillus anthracis) from pleated heating, ventilation, and air conditioning (HVAC) filters that are typically found in commercial and residential buildings. Electrostatic and mechanical HVAC filters were tested, both without and after loading with dust to 50% of their total holding capacity. The results were analyzed by one-way ANOVA across material types, presence or absence of dust, and sampling device. The extraction method gave higher relative recoveries than the two vacuum methods evaluated (p <= 0.001). On average, recoveries obtained by the vacuum methods were about 30% of those achieved by the extraction method. Relative recoveries between the two vacuum methods were not significantly different (p > 0.05). Although extraction methods yielded higher recoveries than vacuum methods, either HVAC filter sampling approach may provide a rapid and inexpensive mechanism for understanding the extent of contamination following a wide-area biological release incident. Published by Elsevier B.V. C1 [Calfee, M. Worth; Tufts, Jenia] US EPA, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Rose, Laura J.; Morse, Stephen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tufts, Jenia] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Clayton, Matt; Touati, Abderrahmane; Griffin-Gatchalian, Nicole; McSweeney, Neal] ARCADIS Geraghty & Miller Inc, Durham, NC USA. [Slone, Christina] Kultech Inc, Cary, NC USA. RP Calfee, MW (reprint author), US EPA, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM calfee.worth@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development [EP-C-09-027]; CDC [RW-75-92345701]; U.S. EPA [RW-75-92345701]; ARCADIS, Inc. FX The U.S. Environmental Protection Agency, through its Office of Research and Development, directed the research described herein under EP-C-09-027 with ARCADIS, Inc. This study was funded through an interagency agreement between the CDC and the U.S. EPA (RW-75-92345701). This manuscript has been subject to an administrative review but the findings and conclusions in this article are of the authors, and do not necessarily reflect the views of the EPA or CDC. No official endorsement should be inferred. The U.S. EPA and CDC do not endorse the purchase or sale of any commercial products or services. NR 27 TC 4 Z9 4 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JAN PY 2014 VL 96 BP 1 EP 5 DI 10.1016/j.mimet.2013.10.012 PG 5 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 290PO UT WOS:000329771000001 PM 24184312 ER PT J AU Gilbert, SE Rose, LJ Howard, M Bradley, MD Shah, S Silvestri, E Schaefer, FW Noble-Wang, J AF Gilbert, Sarah E. Rose, Laura J. Howard, Michele Bradley, Meranda D. Shah, Sanjiv Silvestri, Erin Schaefer, Frank W., III Noble-Wang, Judith TI Evaluation of swabs and transport media for the recovery of Yersinia pestis SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Yersinia pestis; Transport media; Swab; Recovery ID BACILLUS-ANTHRACIS SPORES; PROCESSING METHOD; SURFACE; PERSISTENCE; SURVIVAL; WATER AB The Government Accountability Office report investigating the surface sampling methods used during the 2001 mail contamination with Bacillus anthracis brought to light certain knowledge gaps that existed regarding environmental sampling with biothreat agents. Should a contamination event occur that involves non-spore forming biological select agents, such as Yersinia pestis, surface sample collection and processing protocols specific for these organisms will be needed. Two Y. pestis strains (virulent and avirulent), four swab types (polyester, macrofoam, rayon, and cotton), two pre-moistening solutions, six transport media, three temperatures, two levels of organic load, and four processing methods (vortexing, sonicating, combined sonicating and vortexing, no agitation) were evaluated to determine the conditions that would yield the highest percent of cultivable Y. pestis cells after storage. The optimum pre-moistening agent/transport media combination varied with the Y. pestis strain and swab type. Directly inoculated macrofoam swabs released the highest percent of cells into solution (93.9% recovered by culture) and rayon swabs were considered the second best swab option (77.0% recovered by culture). Storage at 4 degrees C was found to be optimum for all storage times and transport media. In a worst case scenario, where the Y. pestis strain is not known and sample processing and analyses could not occur until 72 h after sampling, macrofoam swabs pre-moistened with PBS supplemented with 0.05% Triton X-100 (PBSTX), stored at 4 degrees C in neutralizing buffer (NB) as a transport medium (PBSTX/NB) or pre-moistened with NB and stored in PBSTX as a transport medium (NB/PBSTX), then vortexed 3 min in the transport medium, performed significantly better than all other conditions for macrofoam swabs, regardless of strain tested (mean 12 72 h recovery of 85.9-105.1%, p < 0.001). In the same scenario, two combinations of pre-moistening medium/transport medium were found to be optimal for rayon swabs stored at 4 degrees C (p < 0.001), then sonicated 3 min in the transport medium; PBSTX/PBSTX and NB/PBSTX (mean 12-72 h recovery of 83.7-110.1%). Published by Elsevier B.V. C1 [Gilbert, Sarah E.] North Adams Reg Hosp, North Adams, MA USA. [Rose, Laura J.; Howard, Michele; Bradley, Meranda D.; Noble-Wang, Judith] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Shah, Sanjiv; Silvestri, Erin; Schaefer, Frank W., III] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. RP Rose, LJ (reprint author), 1600 Clifton Rd NE,MS-C16, Atlanta, GA 30329 USA. EM lrose@cdc.gov NR 20 TC 1 Z9 2 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JAN PY 2014 VL 96 BP 35 EP 41 DI 10.1016/j.mimet.2013.10.017 PG 7 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 290PO UT WOS:000329771000007 PM 24184311 ER PT J AU Schilling, KA Cartwright, EJ Stamper, J Locke, M Esposito, DH Balaban, V Mintz, E AF Schilling, Katharine A. Cartwright, Emily J. Stamper, John Locke, Michael Esposito, Douglas H. Balaban, Victor Mintz, Eric TI Diarrheal Illness Among US Residents Providing Medical Services in Haiti During the Cholera Epidemic, 2010 to 2011 SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID TRAVELERS AB Although nosocomial transmission of cholera is rare, two US healthcare workers (HCW) became ill with cholera after providing medical services during the Haiti cholera epidemic. To assess the incidence of diarrheal illness and explore preventive health behaviors practiced by US residents who provided medical services in Haiti, we conducted a cross-sectional, anonymous, web-based survey. We e-mailed 896 participants from 50 US-based, health-focused non-governmental organizations (NGOs), of whom 381 (43%) completed the survey. Fifty-six percent of respondents (n=215) reported providing some care for patients with cholera. Diarrhea was reported by 31 (8%) respondents. One person was diagnosed with cholera by serologic testing. NGOs responding to international emergencies should ensure ample access to basic hygiene supplies and should promote their use to reduce the incidence of diarrheal illness among HCW working overseas. C1 [Schilling, Katharine A.; Cartwright, Emily J.; Mintz, Eric] US Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Waterborne Dis Prevent Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30307 USA. [Cartwright, Emily J.] CDC, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, OSELS, Atlanta, GA 30333 USA. [Cartwright, Emily J.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Stamper, John] US Ctr Dis Control & Prevent, Off Director, Off Informat, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30307 USA. [Locke, Michael] US Ctr Dis Control & Prevention Via Sci Applicat, Div Foodborne Waterborne & Environm Dis, Waterborne Dis Prevent Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30307 USA. [Esposito, Douglas H.; Balaban, Victor] US Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Travelers Hlth Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30307 USA. RP Schilling, KA (reprint author), US Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Waterborne Dis Prevent Branch, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,Mailstop C09, Atlanta, GA 30307 USA. EM kschilling@cdc.gov NR 11 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1195-1982 EI 1708-8305 J9 J TRAVEL MED JI J. Travel Med. PD JAN PY 2014 VL 21 IS 1 BP 55 EP 57 DI 10.1111/jtm.12075 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 285DC UT WOS:000329372400011 PM 24383654 ER PT J AU Jentes, ES Blanton, JD Johnson, KJ Petersen, BW Lamias, MJ Robertson, K Franka, R Muhm, D Rupprecht, CE Marano, N Brunette, GW AF Jentes, Emily S. Blanton, Jesse D. Johnson, Katherine J. Petersen, Brett W. Lamias, Mark J. Robertson, Kis Franka, Richard Muhm, Daniel Rupprecht, Charles E. Marano, Nina Brunette, Gary W. TI The Global Availability of Rabies Immune Globulin and Rabies Vaccine in Clinics Providing Indirect Care to Travelers SO JOURNAL OF TRAVEL MEDICINE LA English DT Article AB We assessed rabies vaccine (RV) and immune globulin (RIG) availability on the local market by querying US Embassy medical staff worldwide. Of 112 responses, 23% were from West, Central, and East Africa. RV and RIG availability varied by region. Possible rabies exposures accounted for 2% of all travelers' health inquiries. C1 [Jentes, Emily S.; Johnson, Katherine J.; Marano, Nina; Brunette, Gary W.] Ctr Dis Control & Prevent CDC, Div Global Migrat & Quarantine, NCEZID, Atlanta, GA 30333 USA. [Blanton, Jesse D.; Petersen, Brett W.; Robertson, Kis; Franka, Richard] CDC, Div High Consequence Pathogens & Pathol, NCEZID, Atlanta, GA 30333 USA. [Lamias, Mark J.] CDC, Off Informat, NCEZID, Atlanta, GA 30333 USA. [Lamias, Mark J.] Sci Applicat Int Corp, Atlanta, GA USA. [Muhm, Daniel] US Dept State, Off Med Serv, Washington, DC 20520 USA. [Rupprecht, Charles E.] Global Alliance Rabies Control, Manhattan, KS USA. RP Jentes, ES (reprint author), Ctr Dis Control & Prevent CDC, Div Global Migrat & Quarantine, 1600 Clifton Rd NE,MS E-03, Atlanta, GA 30333 USA. EM efj8@cdc.gov FU C.E.R. FX C.E.R. Research sponsorship was the following: During the past 2 years, travel support for participation in rabies seminars and research support for development of new rabies biologics via organizations that produce rabies products. The other authors state they have no conflicts of interest to declare. NR 8 TC 5 Z9 5 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1195-1982 EI 1708-8305 J9 J TRAVEL MED JI J. Travel Med. PD JAN PY 2014 VL 21 IS 1 BP 62 EP 66 DI 10.1111/jtm.12085 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 285DC UT WOS:000329372400013 PM 24267775 ER PT J AU Fenton, KA Aquino, GA Dean, HD AF Fenton, Kevin A. Aquino, Gustavo A. Dean, Hazel D. TI PROGRAM COLLABORATION AND SERVICE INTEGRATION IN THE PREVENTION AND CONTROL OF HIV INFECTION, VIRAL HEPATITIS, STDs, AND TUBERCULOSIS IN THE US: LESSONS LEARNED FROM THE FIELD SO PUBLIC HEALTH REPORTS LA English DT Editorial Material ID HEALTH; CDC C1 [Aquino, Gustavo A.] Ctr Dis Control & Prevent CDC, Program Integrat, Atlanta, GA USA. [Fenton, Kevin A.; Dean, Hazel D.] Ctr Dis Control & Prevent CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Aquino, GA (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Off Director, 1600 Clifton Rd NE,MS E-07, Atlanta, GA 30333 USA. EM gaa1@cdc.gov NR 28 TC 1 Z9 1 U1 1 U2 5 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 1 EP 4 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000001 PM 24385642 ER PT J AU Will, JC Nwaise, IA Schieb, L Zhong, YN AF Will, Julie C. Nwaise, Isaac A. Schieb, Linda Zhong, Yuna TI Geographic and Racial Patterns of Preventable Hospitalizations for Hypertension: Medicare Beneficiaries, 2004-2009 SO PUBLIC HEALTH REPORTS LA English DT Article ID CARE-SENSITIVE CONDITIONS; HEALTH-CARE; RATES; DISPARITIES; POPULATION; ASSOCIATION; ACCESS; IMPACT AB Objectives. Hypertension as the primary reason for hospitalization is often used to indicate failure of the outpatient health-care system to prevent and control high blood pressure. Investigators have reported increased rates of these preventable hospitalizations for black people compared with white people; however, none have mapped them nationally by race. Methods. We used Medicare Part A data to estimate preventable hypertension hospitalizations from 2004-2009 using technical specifications published by the Agency for Healthcare Research and Quality. Rates per 100,000 beneficiaries were age- and sex-standardized to 2000 U.S. Census data. We mapped county-level rates by race and identified clusters of counties with extreme rates. Results. Black people had higher crude rates of these hospitalizations than white people for every year studied, and the test for an increasing linear time trend for the standardized rates was significant for both black and white people; that is, the gap between the races increased over time. For both races, clusters of high-rate counties occurred primarily in parts of Oklahoma, Texas, Southern Alabama, and Louisiana. High rates for white people were also found in parts of Appalachia. Large differences in rates among black and white people were found in a number of large urban areas and in parts of Florida and Alabama. Conclusions. Racial disparities in preventable hospitalizations for hypertension persisted through 2009. The gap between black and white people is increasing, and these inequities exist unevenly across the country. Although this study was intended to be purely descriptive, future studies should use multivariate analyses to examine reasons for these unequal distributions. C1 [Will, Julie C.; Nwaise, Isaac A.; Schieb, Linda; Zhong, Yuna] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Will, JC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,MS F-72, Atlanta, GA 30341 USA. EM jxw6@cdc.gov RI Dalla Zuanna, Teresa/G-3133-2015 NR 34 TC 8 Z9 8 U1 1 U2 7 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 IS 1 BP 8 EP 18 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BL UT WOS:000329586900003 PM 24381355 ER PT J AU Okoro, CA Stoodt, G Rohrer, JE Strine, TW Li, CY Balluz, LS AF Okoro, Catherine A. Stoodt, Georjean Rohrer, James E. Strine, Tara W. Li, Chaoyang Balluz, Lina S. TI Physical Activity Patterns Among U.S. Adults with and without Serious Psychological Distress SO PUBLIC HEALTH REPORTS LA English DT Article ID FACTOR SURVEILLANCE SYSTEM; RANDOMIZED CONTROLLED-TRIAL; HEALTH INTERVIEW SURVEY; GENERAL-POPULATION; MENTAL-ILLNESS; DEPRESSIVE SYMPTOMS; NATIONAL-HEALTH; OLDER-ADULTS; PRIMARY-CARE; DISORDERS AB Objective. A physically active lifestyle is recommended for overall health both physical and mental. Serious psychological distress (SPD) is associated with adverse health behaviors. We compared patterns of physical activity (PA) among adults with and without SPD using current public health guidelines for PA and examined whether adults with SPD were physically active at recommended levels. Methods. We used data from the 2009 Behavioral Risk Factor Surveillance System (BRFSS) to assess SPD using the Kessler 6 (K6) scale of nonspecific psychological distress and PA categories based on the 2008 U.S. Department of Health and Human Services guidelines. Complete data were available for 78,886 adults in 16 states that used an optional BRFSS mental illness and stigma module containing the K6 scale. We performed multiple logistic regression analyses to estimate prevalence ratios (PRs) and 95% confidence intervals (Cls). Results. The unadjusted prevalence of SPD was 3.9% (95% Cl 3.6, 4.2), and the age-adjusted prevalence of SPD was 3.8% (95% Cl 3.5, 4.1). After adjusting for age, sex, race/ethnicity, education, employment, body mass index, smoking status, and heavy drinking, adults with SPD were significantly less likely to be physically active at recommended levels than adults without SPD. PRs were attenuated but remained significant after further adjustment for limitations to PA. Conclusion. Adults with SPD are less likely to meet current PA recommendations than adults without SPD, highlighting the need for targeted interventions. C1 [Okoro, Catherine A.; Li, Chaoyang; Balluz, Lina S.] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance & Informat Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. [Stoodt, Georjean; Rohrer, James E.] Walden Univ, Coll Hlth Sci, Sch Hlth Sci, Minneapolis, MN USA. [Strine, Tara W.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. RP Okoro, CA (reprint author), Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance & Informat Program Off, Div Behav Surveillance, 1600 Clifton Rd NE,MS E-97, Atlanta, GA 30333 USA. EM cokoro@cdc.gov NR 54 TC 5 Z9 6 U1 0 U2 9 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 IS 1 BP 30 EP 38 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BL UT WOS:000329586900005 PM 24381357 ER PT J AU Harris, LEF Toledo, L Dunbar, E Aquino, GA Nesheim, SR AF Harris, Lauren E. Fitz Toledo, Lauren Dunbar, Erica Aquino, Gustavo A. Nesheim, Steven R. TI Program Collaboration and Service Integration Activities Among HIV Programs in 59 US Health Departments SO PUBLIC HEALTH REPORTS LA English DT Article ID VIRAL-HEPATITIS; STD; SURVEILLANCE; PREVENTION; STATE; CDC; TB AB Objectives. We identified the level and type of program collaboration and service integration (PCSI) among HIV prevention programs in 59 CDC-funded health department jurisdictions. Methods. Annual progress reports (APRs) completed by all 59 health departments funded by CDC for HIV prevention activities were reviewed for collaborative and integrated activities reported by HIV programs for calendar year 2009. We identified associations between PCSI activities and funding, AIDS diagnosis rate, and organizational integration. Results. HIV programs collaborated with other health department programs through data-related activities, provider training, and providing funding for sexually transmitted disease (STD) activities in 24 (41%), 31(53%), and 16 (27%) jurisdictions, respectively. Of the 59 jurisdictions, 57 (97%) reported integrated HIV and STD testing at the same venue, 39 (66%) reported integrated HIV and tuberculosis testing, and 26 (44%) reported integrated HIV and viral hepatitis testing. Forty-five (76%) jurisdictions reported providing integrated education/ outreach activities for HIV and at least one other disease. Twenty-six (44%) jurisdictions reported integrated partner services among HIV and STD programs. Overall, the level of PCSI activities was not associated with HIV funding, AIDS diagnoses, or organizational integration. Conclusions. HIV programs in health departments collaborate primarily with STD programs. Key PCSI activities include integrated testing, integrated education/outreach, and training. Future assessments are needed to evaluate PCSI activities and to identify the level of collaboration and integration among prevention programs. C1 [Harris, Lauren E. Fitz; Toledo, Lauren; Dunbar, Erica; Aquino, Gustavo A.; Nesheim, Steven R.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Harris, Lauren E. Fitz; Toledo, Lauren] ICF Int, Atlanta, GA USA. RP Harris, LEF (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-45, Atlanta, GA 30333 USA. EM lfitzharris@cdc.gov NR 19 TC 4 Z9 4 U1 1 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 33 EP 42 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000006 ER PT J AU Hunter, P Oyervides, O Grande, KM Prater, D Vann, V Reitl, I Biedrzycki, PA AF Hunter, Paul Oyervides, Otilio Grande, Katarina M. Prater, Daphne Vann, Vannessa Reitl, Irmine Biedrzycki, Paul A. TI Facebook-Augmented Partner Notification in a Cluster of Syphilis Cases in Milwaukee SO PUBLIC HEALTH REPORTS LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; INTERNET; HIV; MEN; SEX; NETWORK; SURVEILLANCE; PREVENTION AB Public health professionals face many challenges in infectious disease cluster case identification and partner notification (PN), especially in populations using social media as a primary communication venue. We present a method using Facebook and social network diagram illustration to identify, link, and notify individuals in a cluster of syphilis cases in young black men who have sex with men (MSM). Use of Facebook was crucial in identifying two of 55 individuals with syphilis, and the cooperation of socially connected individuals with traditional PN methods yielded a high number of contacts per case. Integration of PN services for HIV and sexually transmitted diseases, as well as collaboration between the city and state information systems, assisted in the cluster investigation. Given that rates of syphilis and HIV infection are increasing significantly in young African American MSM, the use of social media can provide an additional avenue to facilitate case identification and notification. C1 [Hunter, Paul] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Hunter, Paul; Oyervides, Otilio; Grande, Katarina M.; Prater, Daphne; Vann, Vannessa; Reitl, Irmine; Biedrzycki, Paul A.] City Milwaukee Hlth Dept, Milwaukee, WI 53202 USA. [Oyervides, Otilio] Ctr Dis Control & Prevent, Atlanta, GA USA. [Grande, Katarina M.] Univ Wisconsin, Populat Hlth Inst, Madison, WI USA. RP Hunter, P (reprint author), City Milwaukee Hlth Dept, 841 N Broadway 315, Milwaukee, WI 53202 USA. EM phunte@milwaukee.gov NR 32 TC 9 Z9 9 U1 2 U2 12 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 43 EP 49 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000007 PM 24385648 ER PT J AU Viner, K Perella, D Lopez, A Bialek, S Nguyen, M Spells, N Watson, B AF Viner, Kendra Perella, Dana Lopez, Adriana Bialek, Stephanie Nguyen, Michael Spells, Niya Watson, Barbara TI Comparing Active and Passive Varicella Surveillance in Philadelphia, 2005-2010: Recommendations for the Transition to Nationwide Passive Varicella Disease Surveillance SO PUBLIC HEALTH REPORTS LA English DT Article AB Objective. The Philadelphia Department of Public Health (PDPH) conducts active surveillance for varicella in West Philadelphia. For its approximately 300 active surveillance sites, PDPH mandates biweekly reports of varicella (including zero cases) and performs intensive case investigations. Elsewhere in Philadelphia, surveillance sites passively report varicella cases, and abbreviated investigations are conducted. We used active varicella surveillance program data to inform the transition to nationwide passive varicella surveillance. Methods. We compared classification of reported cases, varicella disease incidence, and reporting completeness for active and passive surveillance areas for 2005-2010. We assessed reporting completeness using capture-recapture analysis of 2- to 18-year-old cases reported by schools/daycare centers and health-care providers. Results. From 2005 to 2010, PDPH received 3,280 passive and 969 active surveillance varicella case reports. Most passive surveillance reports were classified as probable cases (18% confirmed, 56% probable, and 26% excluded), whereas nearly all of the active surveillance reports were either confirmed or excluded (36% confirmed, 11% probable, and 53% excluded). Overall incidence rates calculated using confirmed/probable cases were similar in the active and passive surveillance areas. Detection of laboratory-confirmed, breakthrough, and moderate-to-severe cases was equivalent for both surveillance areas. Conclusions. Although active surveillance for varicella results in better classified cases, passive surveillance provides comparable data for monitoring disease trends in breakthrough and moderate-to-severe varicella. To further improve passive surveillance in the two-dose-varicella vaccine era, jurisdictions should consider conducting periodic enhanced surveillance, encouraging laboratory testing, and collecting additional varicella-specific variables for passive surveillance. C1 [Viner, Kendra; Perella, Dana; Spells, Niya; Watson, Barbara] Philadelphia Dept Publ Hlth, Philadelphia, PA 19146 USA. [Lopez, Adriana; Bialek, Stephanie] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nguyen, Michael] US FDA, Rockville, MD 20857 USA. RP Viner, K (reprint author), Philadelphia Dept Publ Hlth, Div Dis Control, 500 S Broad St, Philadelphia, PA 19146 USA. EM kendra.viner@phila.gov NR 15 TC 0 Z9 0 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 IS 1 BP 47 EP 54 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BL UT WOS:000329586900007 PM 24381359 ER PT J AU Hutton, HE Chander, G Green, PP Hutsell, CA Weingarten, K Peterson, KL AF Hutton, Heidi E. Chander, Geetanjali Green, Patricia P. Hutsell, Catherine A. Weingarten, Kimberly Peterson, Karen L. TI A Novel Integration Effort to Reduce the Risk for Alcohol-Exposed Pregnancy Among Women Attending Urban STD Clinics SO PUBLIC HEALTH REPORTS LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; RANDOMIZED CONTROLLED-TRIAL; MOTIVATIONAL INTERVENTION; CHILDBEARING AGE; ADOLESCENTS; PREVENTION; CARE; INFECTION; DISORDERS; BEHAVIORS AB Alcohol-exposed pregnancy (AEP) is a significant public health Problem in the United States. Sexually transmitted disease (STD) clinics serve female clients with a high prevalence of heavy alcohol consumption coupled with ineffective contraceptive use. Project CHOICES (Changing High-Rik AlcOhol Use and Increasing Contraception Effectiveness) is an evidence-based, brief intervention to lower risk of AEP by targeting alcohol and contraceptive behaviors through motivational interviewing and individualized feedback. We describe our experience integrating and implementing CHOICES in STD clinics. This endeavor aligns with CDC's National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention's program collaboration and service integration strategic priority to strengthen collaborative work across disease areas and integrate services provided by related programs at the client level. C1 [Hutton, Heidi E.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, AIDS Psychiat Serv, Baltimore, MD USA. [Chander, Geetanjali] Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD USA. [Green, Patricia P.; Hutsell, Catherine A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Prevent Res Branch, Atlanta, GA USA. [Weingarten, Kimberly] Druid STD Clin, Baltimore City Hlth Dept, Baltimore, MD USA. [Peterson, Karen L.] Denver Publ Hlth, Denver, CO 80204 USA. RP Peterson, KL (reprint author), Denver Publ Hlth, 605 Bannock St, Denver, CO 80204 USA. EM kpeterso@dhha.org NR 28 TC 5 Z9 5 U1 1 U2 10 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 56 EP 62 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000009 PM 24385650 ER PT J AU Elmore, K Nelson, R Gant, Z Jeffries, C Broeker, L Mirabito, M Roberts, H AF Elmore, Kim Nelson, Rob Gant, Zanetta Jeffries, Carla Broeker, Lance Mirabito, Massimo Roberts, Henry TI Data Harmonization Process for Creating the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Atlas SO PUBLIC HEALTH REPORTS LA English DT Article AB In 2009, the CDC National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) initiated the online, interactive NCHHSTP Atlas. The goal of the Atlas is to strengthen the capacity to monitor the diseases overseen by NCHHSTP and to illustrate demographic, spatial, and temporal variation in disease patterns. The Atlas includes HIV, AIDS, viral hepatitis, sexually transmitted disease, and tuberculosis surveillance data, and aims to provide a single point of access to meet the analytical and data dissemination needs of NCHHSTP. To accoMplish this goal, an NCHHSTP-wide Data Harmonization Workgroup reviewed surveillance data collected by each division to harmonize the data across diseases, allowing one to query data and generate comparable maps and tables via the same user interface. Although we were not able to harmonize all data elements, data standardization is necessary and work continues toward that goal. C1 [Elmore, Kim; Gant, Zanetta] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Nelson, Rob] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div STD Prevent, Atlanta, GA 30333 USA. [Jeffries, Carla] Northrop Grumman Corp, Falls Church, VA USA. [Broeker, Lance; Mirabito, Massimo] Agcy Tox Subst & Dis Registry, Geospatial Res Anal & Serv Program, Atlanta, GA USA. [Roberts, Henry] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA 30333 USA. RP Elmore, K (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E48, Atlanta, GA 30333 USA. EM kelmore@cdc.gov NR 16 TC 2 Z9 2 U1 0 U2 4 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 63 EP 69 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000010 PM 24385651 ER PT J AU Mitruka, K Blake, H Ricks, P Miramontes, R Bamrah, S Chee, C Hickstein, L AF Mitruka, Kren Blake, Haley Ricks, Philip Miramontes, Roque Bamrah, Sapna Chee, Carla Hickstein, Laurie TI A Tuberculosis Outbreak Fueled by Cross-Border Travel and Illicit Substances: Nevada and Arizona SO PUBLIC HEALTH REPORTS LA English DT Article ID UNDOCUMENTED FOREIGN-BORN; UNITED-STATES; PUBLIC-HEALTH; TRANSMISSION; SURVEILLANCE; IMMIGRATION; FAILURE; USERS AB Objectives. From May 2006 to August 2008, the Southern Nevada Health District identified eight tuberculosis (TB) cases in six adults and two children in a Hispanic community. We conducted an outbreak investigation to determine the extent of TB transmission and prevent additional cases. Methods. We investigated TB cases in Nevada and Arizona with the outbreak genotype or cases with suspected epidemiologic links to this cluster but without genotyping data. We reviewed medical records and interviewed patients and contacts. Subsequently, genotype surveillance was conducted for approximately four years to monitor additional outbreak-related cases. Results. Eight outbreak cases were identified among six adults and two children. All patients were Hispanic and five were U.S.-born. The index patient was diagnosed while detained in Immigration and Customs Enforcement custody but deported before treatment completion. He was lost to follow-up for two years, during which time he served as the source for six secondary TB cases, including his own child. Along with the index patient, five patients reportedly engaged in the sale or use of methamphetamine. Follow-up surveillance in the two states identified eight additional cases with the outbreak genotype; three had epidemiologic links to the index case. Conclusions. We found that incomplete TB treatment led to extensive TB transmission. We recommend thorough discharge planning and active measures to ensure continuity of care and TB treatment completion for people in custody at higher risk for loss to follow-up, which likely includes those engaged in the sale or use of illicit substances. C1 [Mitruka, Kren; Ricks, Philip; Miramontes, Roque; Bamrah, Sapna] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Blake, Haley; Hickstein, Laurie] Southern Nevada Hlth Dist, TB Treatment & Control Clin, Las Vegas, NV USA. [Chee, Carla] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. RP Mitruka, K (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Surveillance Epidemiol & Outbreak Invest Branch, 1600 Clifton Rd NE,MS G-37, Atlanta, GA 30333 USA. EM kmitruka@cdc.gov NR 34 TC 1 Z9 1 U1 0 U2 2 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 IS 1 BP 78 EP 85 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BL UT WOS:000329586900011 PM 24381363 ER PT J AU Skinner, JM Distefano, J Warrington, J Bailey, SR Winscott, M Taylor, MM AF Skinner, Julia M. Distefano, Jana Warrington, Jennifer Bailey, S. Robert Winscott, Michelle Taylor, Melanie M. TI Trends in Reported Syphilis and Gonorrhea Among HIV-Infected People in Arizona: Implications for Prevention and Control SO PUBLIC HEALTH REPORTS LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; MEN; RISK; SEX; TRANSMISSION; CHLAMYDIA; DISEASES AB Objective. HIV and sexually transmitted disease (STD) surveillance patterns in Arizona suggested the need for integrated data analyses to identify trends. Methods. We compiled all HIV/AIDS cases diagnosed from 1998 to 2008 that were reported in Arizona and syphilis or gonorrhea cases diagnosed from 1998 to 2008 in Arizona. We used deterministic matching to identify individuals who were diagnosed with HIV and one or more STDs, and calculated time intervals between diagnoses. Results. Of 23,940 people with HIV/AIDS reported from 1998 to 2008, 1,899. (2.6%) had at leak one syphilis or gonorrhea diagnosis from 1998 to 2008. Approximately 85% of these cases reported male-to-male sexual contact. Among males with syphilis, HIV coinfection increased from 0.5% in 1998 to 29.1% in 2008. Among males with gonorrhea, HIV coinfection increased from 2.0% in 1998 to 3.1% in 2008. Among HIV-cases diagnosed from 2004 to 2008 and reported with at least one syphilis or gonorrhea diagnosis, the majority of syphilis cases (76.1%) were diagnosed at or after HIV diagnosis, whereas a majority of gonorrhea cases (54.9%) were diagnosed prior to HIV diagnosis. Conclusion. Use of the deterministic matching method identified increases in STD infections among HIV-infected people. The routine performance of this cross-matching method may be a useful tool in identifying these high-risk individuals so that targeted partner services and appropriate care referrals may be used in a timely fashion. C1 [Skinner, Julia M.; Distefano, Jana; Warrington, Jennifer; Bailey, S. Robert] Arizona Dept Hlth Serv, HIV Surveillance Program, Phoenix, AZ 85007 USA. [Winscott, Michelle] Mayo Clin, Scottsdale, AZ USA. [Taylor, Melanie M.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Taylor, Melanie M.] Arizona Dept Hlth Serv, STD Control Program, Phoenix, AZ 85007 USA. RP Skinner, JM (reprint author), Arizona Dept Hlth Serv, HIV Surveillance Program, 150 N 18th Ave,Ste 110, Phoenix, AZ 85007 USA. EM julia.skinner@azdhs.gov NR 27 TC 4 Z9 4 U1 0 U2 3 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 SU 1 BP 85 EP 94 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BM UT WOS:000329587000013 PM 24385654 ER PT J AU Peterson, C Grosse, SD Glidewell, J Garg, LF Van Naarden, K Knapp, MM Beres, LM Hinton, CF Olney, RS Cassell, CH AF Peterson, Cora Grosse, Scott D. Glidewell, Jill Garg, Lorraine F. Van Naarden, Kim Knapp, Mary M. Beres, Leslie M. Hinton, Cynthia F. Olney, Richard S. Cassell, Cynthia H. TI A Public Health Economic Assessment of Hospitals' Cost to Screen Newborns for Critical Congenital Heart Disease SO PUBLIC HEALTH REPORTS LA English DT Article ID PULSE OXIMETRY; ASYMPTOMATIC NEWBORNS; DEFECTS; INFANTS; STRATEGIES; ACCURACY; MODEL AB Objective. Critical congenital heart disease (CCHD) was recently added to the U.S. Recommended Uniform Screening Panel for newborns. This evaluation aimed to estimate screening time and hospital cost per, newborn screened for CCHD using pulse oximetry as part of a public health economic assessment of CCHD screening. Methods. A cost survey and time and motion study were conducted in well-newborn and special/intensive care nurseries in a random sample of seven birthing hospitals in New Jersey, where the state legislature mandated CCHD screening in 2011. The sample was stratified by hospital facility level, hospital birth census, and geographic location. At the time of the evaluation, all hospitals had conducted CCHD screening for at least four months. Results. Mean screening time per newborn was 9.1 (standard deviation = 3.4) minutes. Hospitals' total mean estimated cost per newborn screened was $14.19 (in 2011 U.S. dollars), consisting of $7.36 in labor costs and $6.83 in equipment and supply costs. Conclusions. This federal agency-state health department collaborative assessment is the first state-level analysis of time and hospital costs for CCHD screening using pulse oximetry conducted in the U.S. Hospitals' cost per newborn screened for CCHD with pulse oximetry is comparable with cost estimates of existing newborn screening tests. Hospitals' equipment costs varied substantially based on the pulse oximetry technology employed, with lower costs among hospitals that used reusable screening sensors. In combination with estimates of screening accuracy, effectiveness, and avoided costs, information from this evaluation suggests that CCHD screening is cost-effective. C1 [Peterson, Cora; Grosse, Scott D.; Glidewell, Jill; Van Naarden, Kim; Hinton, Cynthia F.; Olney, Richard S.; Cassell, Cynthia H.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Garg, Lorraine F.; Knapp, Mary M.; Beres, Leslie M.] New Jersey State Dept Hlth, Div Family Hlth Serv Special Child Hlth & Early I, Trenton, NJ 08625 USA. RP Peterson, C (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Hwy,MS F-62, Atlanta, GA 30341 USA. EM cora.peterson@cdc.hhs.gov OI Peterson, Cora/0000-0001-7955-0977 NR 23 TC 10 Z9 10 U1 0 U2 4 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2014 VL 129 IS 1 BP 86 EP 93 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 288BL UT WOS:000329586900012 PM 24381364 ER PT J AU Maulsby, C Millett, G Lindsey, K Kelley, R Johnson, K Montoya, D Holtgrave, D AF Maulsby, Cathy Millett, Greg Lindsey, Kali Kelley, Robin Johnson, Kim Montoya, Daniel Holtgrave, David TI HIV Among Black Men Who Have Sex with Men (MSM) in the United States: A Review of the Literature SO AIDS AND BEHAVIOR LA English DT Review DE Black men who have sex with men; HIV/AIDS; HIV; Men who have sex with men; Health disparity ID AFRICAN-AMERICAN MEN; NEW-YORK-CITY; ACTIVE ANTIRETROVIRAL THERAPY; MULTICENTER AIDS COHORT; UNPROTECTED ANAL INTERCOURSE; OLDER PARTNER SELECTION; HEALTH-SERVICE USE; CONSPIRACY BELIEFS; MALE CIRCUMCISION; RISK BEHAVIORS AB In 2006, Millett published a seminal literature review that examined 12 hypotheses to explain the high rates of HIV among black MSM. This paper augments Millett's article by reviewing the recent literature on behavioral, biomedical, structural, social contextual, psychosocial, and social network factors that affect HIV rates among black MSM. We searched three databases: PubMed, Scopus, and Google Scholar. First we searched all articles that included black or African American and MSM and HIV. We then searched the following terms for each area: behavioral (drug use during sex, crack cocaine use, and serosorting); biomedical (circumcision, STDs, and STIs); structural (access to care, HIV care, ART, HAART, patient-provider communication, HIV quality of care); social contextual (stigma, discrimination, internalized homophobia, internalized heterosexism, medical mistrust, social isolation, and incarceration); psychosocial (peer support and mental health); and social network (sexual mixing, partner characteristics, and social networks) factors. We identified 39 articles to include in this review. We found inconclusive evidence that incarceration, stigma, discrimination, social isolation, mental health disparities, or social networks explain the elevated rates of HIV among black MSM. We found evidence that the differences in rates of HIV between black and white MSM may be explained by differences in STIs, undiagnosed seropositivity, access to care and treatment services, and use of HAART. There is an overwhelming need for HIV testing, linkage to care, retention in care, and adherence programs for black MSM. C1 [Maulsby, Cathy; Holtgrave, David] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD 21205 USA. [Millett, Greg] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Lindsey, Kali; Kelley, Robin; Johnson, Kim; Montoya, Daniel] Natl Minor AIDS Council, Washington, DC USA. RP Maulsby, C (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 624 N Broadway,STE 904C, Baltimore, MD 21205 USA. EM cmaulsby@jhsph.edu NR 115 TC 61 Z9 61 U1 4 U2 41 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2014 VL 18 IS 1 BP 10 EP 25 DI 10.1007/s10461-013-0476-2 PG 16 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 284LB UT WOS:000329317700002 PM 23620241 ER PT J AU Guo, YQ Alderisio, KA Yang, WL Cama, V Feng, YY Xiao, LH AF Guo, Yaqiong Alderisio, Kerri A. Yang, Wenli Cama, Vitaliano Feng, Yaoyu Xiao, Lihua TI Host Specificity and Source of Enterocytozoon bieneusi Genotypes in a Drinking Source Watershed SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID HUMAN WATERBORNE PATHOGENS; EASTERN UNITED-STATES; MOLECULAR CHARACTERIZATION; CRYPTOSPORIDIUM GENOTYPES; CYCLOSPORA-CAYETANENSIS; GIARDIA-DUODENALIS; DAIRY-CATTLE; WASTE-WATER; NEW-YORK; MICROSPORIDIOSIS AB To assess the host specificity of Enterocytozoon bieneusi and to track the sources of E. bieneusi contamination, we genotyped E. bieneusi in wildlife and stormwater from the watershed of New York City's source water, using ribosomal internal transcribed spacer (ITS)-based PCR and sequence analyses. A total of 255 specimens from 23 species of wild mammals and 67 samples from stormwater were analyzed. Seventy-four (29.0%) of the wildlife specimens and 39 (58.2%) of the stormwater samples from streams were PCR positive. Altogether, 20 E. bieneusi genotypes were found, including 8 known genotypes and 12 new ones. Sixteen and five of the genotypes were seen in animals and stormwater from the watershed, respectively, with WL4 being the most common genotype in both animals (35 samples) and stormwater (23 samples). The 20 E. bieneusi genotypes belonged to five genogroups (groups 1, 3, 4, and 7 and an outlier), with only 23/113 (20.4%) E. bieneusi-positive samples belonging to zoonotic genogroup 1 and 3/20 genotypes ever being detected in humans. The two genogroups previously considered host specific, groups 3 and 4, were both detected in multiple groups of mammals. Thus, with the exception of the type IV, Peru11, and D genotypes, which were detected in only 7, 5, and 2 animals, respectively, most E. bieneusi strains in most wildlife samples and all stormwater samples in the watershed had no known public health significance, as these types have not previously been detected in humans. The role of different species of wild mammals in the contribution of E. bieneusi contamination in stormwater was supported by determinations of host-adapted Cryptosporidium species/genotypes in the same water samples. Data from this study indicate that the host specificity of E. bieneusi group 3 is broader than originally thought, and wildlife is the main source of E. bieneusi in stormwater in the watershed. C1 [Guo, Yaqiong; Feng, Yaoyu] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. [Guo, Yaqiong; Yang, Wenli; Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Alderisio, Kerri A.] New York City Dept Environm Protect, Valhalla, NY USA. [Cama, Vitaliano] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014; Yaqiong, Guo/N-4927-2015 OI Xiao, Lihua/0000-0001-8532-2727; FU National Natural Science Foundation of China [31229005, 31110103901]; Fundamental Research Funds for the Central Universities, China; National Special Fund for the State Key Laboratory of Bioreactor Engineering [2060204]; Centers for Disease Control and Prevention FX This work was supported by the National Natural Science Foundation of China (grants 31229005 and 31110103901); Fundamental Research Funds for the Central Universities, China; the National Special Fund for the State Key Laboratory of Bioreactor Engineering (no. 2060204); and the Centers for Disease Control and Prevention. NR 36 TC 32 Z9 33 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JAN PY 2014 VL 80 IS 1 BP 218 EP 225 DI 10.1128/AEM.02997-13 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 277XA UT WOS:000328851400023 PM 24141128 ER PT J AU Stowell, JD Forlin-Passoni, D Radford, K Bate, SL Dollard, SC Bialek, SR Cannon, MJ Schmid, DS AF Stowell, Jennifer D. Forlin-Passoni, Daniela Radford, Kay Bate, Sheri L. Dollard, Sheila C. Bialek, Stephanie R. Cannon, Michael J. Schmid, D. Scott TI Cytomegalovirus Survival and Transferability and the Effectiveness of Common Hand-Washing Agents against Cytomegalovirus on Live Human Hands SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID DAY-CARE-CENTER; INFECTION; TRANSMISSION; DISEASE; EFFICACY; VIRUS; RISK AB Congenital cytomegalovirus (CMV) transmission can occur when women acquire CMV while pregnant. Infection control guidelines may reduce risk for transmission. We studied the duration of CMV survival after application of bacteria to the hands and after transfer from the hands to surfaces and the effectiveness of cleansing with water, regular and antibacterial soaps, sanitizer, and diaper wipes. Experiments used CMV AD169 in saliva at initial titers of 1 x 10(5) infectious particles/ml. Samples from hands or surfaces (points between 0 and 15 min) were placed in culture and observed for at least 2 weeks. Samples were also tested using CMV real-time PCR. After application of bacteria to the hands, viable CMV was recovered from 17/20 swabs at 0 min, 18/20 swabs at 1 min, 5/20 swabs at 5 min, and 4/20 swabs at 15 min. After transfer, duration of survival was at least 15 min on plastic (1/2 swabs), 5 min on crackers and glass (3/4 swabs), and 1 min or less on metal and cloth (3/4 swabs); no viable virus was collected from wood, rubber, or hands. After cleansing, no viable virus was recovered using water (0/22), plain soap (0/20), antibacterial soap (0/20), or sanitizer (0/22). Viable CMV was recovered from 4/20 hands 10 min after diaper wipe cleansing. CMV remains viable on hands for sufficient times to allow transmission. CMV may be transferred to surfaces with reduced viability. Hand-cleansing methods were effective at eliminating viable CMV from hands. C1 [Stowell, Jennifer D.; Cannon, Michael J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Forlin-Passoni, Daniela; Radford, Kay; Bate, Sheri L.; Dollard, Sheila C.; Bialek, Stephanie R.; Schmid, D. Scott] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30329 USA. RP Schmid, DS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30329 USA. EM SSchmid@cdc.gov FU Centers for Disease Control and Prevention; CAPES FX This research was supported in part by appointments (J.D.S., D.F.-P., and S.L.B.) at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the CDC. Additional funding for D.F.-P. was provided by CAPES through an agreement between the Brazilian Ministry of Education and UNIFESP, Sao Paulo, Brazil. NR 27 TC 7 Z9 7 U1 2 U2 31 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JAN PY 2014 VL 80 IS 2 BP 455 EP 461 DI 10.1128/AEM.03262-13 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 282QK UT WOS:000329187100004 PM 24185855 ER PT J AU Purcell, DW Mizuno, Y Smith, DK Grabbe, K Courtenay-Quirk, C Tomlinson, H Mermin, J AF Purcell, David W. Mizuno, Yuko Smith, Dawn K. Grabbe, Kristina Courtenay-Quirk, Cari Tomlinson, Hank Mermin, Jonathan TI Incorporating Couples-Based Approaches into HIV Prevention for Gay and Bisexual Men: Opportunities and Challenges SO ARCHIVES OF SEXUAL BEHAVIOR LA English DT Article DE HIV; Men who have sex with men; Couples counseling; Gay; Bisexual; Sexual orientation ID UNPROTECTED ANAL INTERCOURSE; SEXUAL RISK BEHAVIOR; PREEXPOSURE PROPHYLAXIS; SERODISCORDANT COUPLES; DISCORDANT COUPLES; SECONDARY SYPHILIS; NEGOTIATED SAFETY; LIMITED KNOWLEDGE; RANDOMIZED-TRIAL; HOMOSEXUAL-MEN AB Thirty years after the beginning of the HIV epidemic, gay, bisexual, and other men who have sex with men (collectively called MSM) bear a disproportionate burden of HIV in the United States and continue to acquire a distressingly high number and proportion of new infections. Historically, HIV prevention for MSM has been focused on individual-level behavior change, rarely intervening with MSM as part of a couple. Yet, an estimated 33-67 % of HIV infections among MSM are acquired from primary sexual partners, suggesting that work with MSM as couples could be an important contributor to prevention. Given the emergence of high impact combination HIV prevention, it is timely to consider how work with the broad variety of male couples can improve both personal and community health. Couples HIV testing and counseling for MSM is an important advance for identifying men who are unaware that they are HIV-positive, identifying HIV-discordant couples, and supporting men who want to learn their HIV status with their partner. Once men know their HIV status, new advances in biomedical prevention, which can dramatically reduce risk of HIV transmission or acquisition, allow men to make prevention decisions that can protect themselves and their partners. This paper highlights the present-day challenges and benefits of using a couples-based approach with MSM in the era of combination prevention to increase knowledge of HIV status, increase identification of HIV discordant couples to improve targeting prevention services, and support mutual disclosure of HIV status. C1 [Purcell, David W.; Mizuno, Yuko; Smith, Dawn K.; Grabbe, Kristina; Tomlinson, Hank] Ctr Dis Control & Prevent, Div HIV AIDS Prevent MS D 21, Atlanta, GA 30333 USA. [Courtenay-Quirk, Cari] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Mermin, Jonathan] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP Purcell, DW (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent MS D 21, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM dhp8@cdc.gov OI Purcell, David/0000-0001-8125-5168 FU Intramural CDC HHS [CC999999] NR 103 TC 10 Z9 10 U1 4 U2 13 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0004-0002 EI 1573-2800 J9 ARCH SEX BEHAV JI Arch. Sex. Behav. PD JAN PY 2014 VL 43 IS 1 BP 35 EP 46 DI 10.1007/s10508-013-0205-y PG 12 WC Psychology, Clinical; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 283HL UT WOS:000329236900008 PM 24233328 ER PT J AU Adachi, K Coleman, MS Khan, N Jentes, ES Arguin, P Rao, SR LaRocque, RC Sotir, MJ Brunette, G Ryan, ET Meltzer, MI AF Adachi, Kenji Coleman, Margaret S. Khan, Nomana Jentes, Emily S. Arguin, Paul Rao, Sowmya R. LaRocque, Regina C. Sotir, Mark J. Brunette, Gary Ryan, Edward T. Meltzer, Martin I. CA Global TravEpiNet Consortium TI Economics of Malaria Prevention in US Travelers to West Africa SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE costs; benefits; malaria prevention; pretravel health consultation ID COST-EFFECTIVENESS ANALYSIS; INTERNATIONAL TRAVELERS; UNITED-STATES; CHEMOPROPHYLAXIS; PROPHYLAXIS; KENYA AB Background. Pretravel health consultations help international travelers manage travel-related illness risks through education, vaccination, and medication. This study evaluated costs and benefits of that portion of the health consultation associated with malaria prevention provided to US travelers bound for West Africa. Methods. The estimated change in disease risk and associated costs and benefits resulting from traveler adherence to malaria chemoprophylaxis were calculated from 2 perspectives: the healthcare payer's and the traveler's. We used data from the Global TravEpiNet network of US travel clinics that collect de-identified pretravel data for international travelers. Disease risk and chemoprophylaxis effectiveness were estimated from published medical reports. Direct medical costs were obtained from the Nationwide Inpatient Sample and published literature. Results. We analyzed 1029 records from January 2009 to January 2011. Assuming full adherence to chemoprophylaxis regimens, consultations saved healthcare payers a per-traveler average of $14 (9-day trip) to $372 (30-day trip). For travelers, consultations resulted in a range of net cost of $20 (9-day trip) to a net savings of $32 (30-day trip). Differences were mostly driven by risk of malaria in the destination country. Conclusions. Our model suggests that healthcare payers save money for short- and longer-term trips, and that travelers save money for longer trips when travelers adhere to malaria recommendations and prophylactic regimens in West Africa. This is a potential incentive to healthcare payers to offer consistent pretravel preventive care to travelers. This financial benefit complements the medical benefit of reducing the risk of malaria. C1 [Adachi, Kenji; Coleman, Margaret S.; Khan, Nomana; Jentes, Emily S.; Sotir, Mark J.; Brunette, Gary] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Arguin, Paul] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Rao, Sowmya R.] Univ Massachusetts Med Sch, Dept Quantitat Hlth Sci, Worcester, MA USA. [Rao, Sowmya R.] Bedford VA Med Ctr, Ctr Hlth Qual Outcomes & Econ Res, Bedford, MA USA. [LaRocque, Regina C.; Ryan, Edward T.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [LaRocque, Regina C.; Ryan, Edward T.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Meltzer, Martin I.] Ctr Dis Control & Prevent, Div Preparedness & Emerging Infect, Atlanta, GA 30333 USA. RP Coleman, MS (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, MS E-03,1600 Clifton Rd, Atlanta, GA 30333 USA. EM mcoleman@cdc.gov FU CDC [U19CI000514, U01CK000175] FX This work was supported by the CDC (Cooperative Agreements U19CI000514 and U01CK000175). NR 27 TC 2 Z9 2 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2014 VL 58 IS 1 BP 11 EP 21 DI 10.1093/cid/cit570 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 280QC UT WOS:000329044800009 PM 24014735 ER PT J AU Ly, KN Xing, J Klevens, RM Jiles, RB Holmberg, SD AF Ly, Kathleen N. Xing, Jian Klevens, R. Monina Jiles, Ruth B. Holmberg, Scott D. TI Causes of Death and Characteristics of Decedents With Viral Hepatitis, United States, 2010 SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE viral hepatitis; mortality; death certificates; causes of death ID CHRONIC LIVER-DISEASE; C VIRUS-INFECTION; SUSTAINED VIROLOGICAL RESPONSE; ALL-CAUSE MORTALITY; HEPATOCELLULAR-CARCINOMA; COHORT; CARE; VACCINATION; POPULATION; PREVALENCE AB Background. Previous research indicates that the mortality burden from viral hepatitis is growing, particularly among middle-aged persons. To monitor progress toward prevention goals, it is important to continue to document characteristics and comortalities of these deaths. This study sought to examine demographic characteristics and the most frequent causes of death among decedents with a viral hepatitis-related death. Methods. A cross-sectional study was performed on approximately 2.4 million death records from 2010. We calculated mortality rates for decedents with and without hepatitis A, B, and C virus (HAV, HBV, and HCV) and relative risks for the most frequently cited conditions in decedents with and without HBV and HCV. Results. In 2010, there were 18 473 (0.7%) deaths with HAV, HBV, and HCV listed among causes of death, disproportionately in those aged 45-64 years. Among the 10 frequent causes of death, decedents listing HBV or HCV died, on average, 22-23 years earlier than decedents not listing these infections. HBV- and HCV-infected decedents aged 45-64 years had an increased risk of having the following conditions reported than decedents without these infections: cancer of liver and intrahepatic bile duct; fibrosis, cirrhosis, and other liver diseases; alcohol-related liver disease; gastrointestinal hemorrhage; human immunodeficiency infection; acute and unspecified renal failure; and septicemia (HCV only). Conclusions. Decedents with other causes of death that include HBV or HCV died 22-23 years earlier than decedents not listing these infections. These data suggest and support the need for prevention, early identification, and treatment of HBV and HCV. C1 [Ly, Kathleen N.; Xing, Jian; Klevens, R. Monina; Jiles, Ruth B.; Holmberg, Scott D.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. RP Ly, KN (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd NE,Mailstop G-37, Atlanta, GA 30333 USA. EM kathleenly@cdc.gov FU US Department of Energy; CDC FX Kathleen Ly was supported in part by an appointment to the Research Participation Program at the CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the CDC. NR 37 TC 27 Z9 27 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2014 VL 58 IS 1 BP 40 EP 49 DI 10.1093/cid/cit642 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 280QC UT WOS:000329044800013 PM 24065331 ER PT J AU Ahmed, F Lindley, MC Allred, N Weinbaum, CM Grohskopf, L AF Ahmed, Faruque Lindley, Megan C. Allred, Norma Weinbaum, Cindy M. Grohskopf, Lisa TI Effect of Influenza Vaccination of Healthcare Personnel on Morbidity and Mortality Among Patients: Systematic Review and Grading of Evidence SO CLINICAL INFECTIOUS DISEASES LA English DT Review DE decision making; evidence-based medicine; health personnel; influenza vaccines; quality of healthcare ID LONG-TERM-CARE; RESPIRATORY SYNCYTIAL VIRUS; RANDOMIZED CONTROLLED-TRIAL; CASE DEFINITIONS; ELDERLY-PEOPLE; UNITED-STATES; HOME STAFF; WORKERS; DISEASE; RECOMMENDATIONS AB Background. Influenza vaccination of healthcare personnel (HCP) is recommended in >40 countries. However, there is controversy surrounding the evidence that HCP vaccination reduces morbidity and mortality among patients. Key factors for developing evidence-based recommendations include quality of evidence, balance of benefits and harms, and values and preferences. Methods. We conducted a systematic review of randomized trials, cohort studies, and case-control studies published through June 2012 to evaluate the effect of HCP influenza vaccination on mortality, hospitalization, and influenza cases in patients of healthcare facilities. We pooled trial results using meta-analysis and assessed evidence quality using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results. We identified 4 cluster randomized trials and 4 observational studies conducted in long-term care or hospital settings. Pooled risk ratios across trials for all-cause mortality and influenza-like illness were 0.71 (95% confidence interval [CI], .59-.85) and 0.58 (95% CI, .46-.73), respectively; pooled estimates for all-cause hospitalization and laboratory-confirmed influenza were not statistically significant. The cohort and case-control studies indicated significant protective associations for influenza-like illness and laboratory-confirmed influenza. No studies reported harms to patients. Using GRADE, the quality of the evidence for the effect of HCP vaccination on mortality and influenza cases in patients was moderate and low, respectively. The evidence quality for the effect of HCP vaccination on patient hospitalization was low. The overall evidence quality was moderate. Conclusions. The quality of evidence is higher for mortality than for other outcomes. HCP influenza vaccination can enhance patient safety. C1 [Ahmed, Faruque; Lindley, Megan C.; Allred, Norma] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Weinbaum, Cindy M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Grohskopf, Lisa] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Ahmed, F (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS A-19, Atlanta, GA 30333 USA. EM fahmed@cdc.gov NR 40 TC 61 Z9 61 U1 1 U2 15 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2014 VL 58 IS 1 BP 50 EP 57 DI 10.1093/cid/cit580 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 280QC UT WOS:000329044800014 PM 24046301 ER PT J AU Mathison, BA Pritt, BS AF Mathison, Blaine A. Pritt, Bobbi S. TI Laboratory Identification of Arthropod Ectoparasites SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Review ID RICKETTSIA-FELIS; URINARY MYIASIS; LYME-DISEASE; DIPTERA CALLIPHORIDAE; MEGASELIA-SCALARIS; INTESTINAL MYIASIS; SERICATA DIPTERA; ERISTALIS-TENAX; UNITED-STATES; TICKS ACARI AB The collection, handling, identification, and reporting of ectoparasitic arthropods in clinical and reference diagnostic laboratories are discussed inthisreview. Included are data on ticks, mites, lice, fleas, myiasis-causing flies, and bed bugs. The public health importance of these organisms is briefly discussed. The focus is on the morphological identification and proper handling and reporting of cases involving arthropod ectoparasites, particularly those encountered in the United States. Other arthropods and other organisms not of public health concern, but routinely submitted to laboratories for identification, are also briefly discussed. C1 [Mathison, Blaine A.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Pritt, Bobbi S.] Mayo Clin, Div Clin Microbiol, Rochester, MN USA. RP Mathison, BA (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. EM gqa4@cdc.gov OI Pritt, Bobbi/0000-0003-0261-1326 NR 139 TC 6 Z9 6 U1 1 U2 19 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 EI 1098-6618 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD JAN PY 2014 VL 27 IS 1 BP 48 EP 67 DI 10.1128/CMR.00008-13 PG 20 WC Microbiology SC Microbiology GA 284NC UT WOS:000329324800003 PM 24396136 ER PT J AU Parola, P Paddock, CD Socolovschi, C Labruna, MB Mediannikov, O Kernif, T Abdad, MY Stenos, J Bitam, I Fournier, PE Raoult, D AF Parola, Philippe Paddock, Christopher D. Socolovschi, Cristina Labruna, Marcelo B. Mediannikov, Oleg Kernif, Tahar Abdad, Mohammad Yazid Stenos, John Bitam, Idir Fournier, Pierre-Edouard Raoult, Didier TI Update on Tick-Borne Rickettsioses around the World: a Geographic Approach (vol 26, pg 657, 2013) SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Correction C1 [Parola, Philippe] Aix Marseille Univ, Unite Rech Malad Infect & Trop Emergentes, UM63,Fac Med, CNRS 7278,IRD 198,WHO Collaborat Ctr Rickettslose, Marseille, France. Ctr Dis Control & Prevent, Atlanta, GA USA. Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Sao Paulo, Brazil. Inst Pasteur, Serv Ecol Syst Vectoriels, Algiers, Algeria. Murdoch Univ, Australian Rickettsial Reference Lab, Div Vet & Biomed Sci, Barwon Hlth, Geelong, Vic, Australia. Univ Boumerdes, Boumerdes, Algeria. RP Parola, P (reprint author), Aix Marseille Univ, Unite Rech Malad Infect & Trop Emergentes, UM63,Fac Med, CNRS 7278,IRD 198,WHO Collaborat Ctr Rickettslose, Marseille, France. RI Mediannikov, Oleg/H-4018-2015 OI Mediannikov, Oleg/0000-0001-6039-2008 NR 1 TC 3 Z9 3 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 EI 1098-6618 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD JAN PY 2014 VL 27 IS 1 BP 166 EP 166 DI 10.1128/CMR.00104-13 PG 1 WC Microbiology SC Microbiology GA 284NC UT WOS:000329324800008 ER PT J AU Li, YX Yin, ZD Shao, ZJ Li, MS Liang, XF Sandhu, HS Hadler, SC Li, JH Sun, YQ Li, J Zou, WJ Lin, M Zuo, SY Mayer, LW Novak, RT Zhu, BQ Xu, L Luo, HM AF Li, Yixing Yin, Zundong Shao, Zhujun Li, Manshi Liang, Xiaofeng Sandhu, Hardeep S. Hadler, Stephen C. Li, Junhong Sun, Yinqi Li, Jing Zou, Wenjing Lin, Mei Zuo, Shuyan Mayer, Leonard W. Novak, Ryan T. Zhu, Bingqing Xu, Li Luo, Huiming CA Acute Meningitis Encephalitis TI Population-based Surveillance for Bacterial Meningitis in China, September 2006-December 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID INFLUENZAE TYPE-B; REAL-TIME PCR; HAEMOPHILUS-INFLUENZAE; STREPTOCOCCUS-PNEUMONIAE; NEISSERIA-MENINGITIDIS; CHILDREN; EPIDEMIOLOGY; ENCEPHALITIS; BANGLADESH; DISEASES AB During September 2006 December 2009, we conducted active population and sentinel laboratory based surveillance for bacterial meningitis pathogens, including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b, in 4 China prefectures. We identified 7,876 acute meningitis and encephalitis syndrome cases, including 6,388 among prefecture residents. A total of 833 resident cases from sentinel hospitals met the World Health Organization case definition for probable bacterial meningitis; 339 of these cases were among children <5 years of age. Laboratory testing confirmed bacterial meningitis in 74 of 3,391 tested cases. The estimated annual incidence (per 100,000 population) of probable bacterial meningitis ranged from 1.84 to 2.93 for the entire population and from 6.95 to 22.30 for children <5 years old. Active surveillance with laboratory confirmation has provided a population-based estimate of the number of probable bacterial meningitis cases in China, but more complete laboratory testing is needed to better define the epidemiology of the disease in this country. C1 [Li, Yixing; Yin, Zundong; Liang, Xiaofeng; Li, Junhong; Luo, Huiming] Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China. [Shao, Zhujun] Natl Inst Communicable Dis Control & Prevent, Beijing, Peoples R China. [Li, Manshi] Shandong Prov Ctr Dis Control & Prevent, Jinan, Peoples R China. [Sandhu, Hardeep S.; Hadler, Stephen C.; Mayer, Leonard W.; Novak, Ryan T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sun, Yinqi; Li, Jing] Hebei Prov Ctr Dis Control & Prevent, Shijiazhuang, Peoples R China. [Zou, Wenjing] Hubei Prov Ctr Dis Control & Prevent, Wuhan, Peoples R China. [Lin, Mei] Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China. [Zuo, Shuyan] World Hlth Org China Off, Beijing, Peoples R China. [Zhu, Bingqing; Xu, Li] State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China. RP Luo, HM (reprint author), Chinese Ctr Dis Control & Prevent, Natl Immunizat Programme, 27 Nanwei Rd, Beijing 100050, Peoples R China. EM hmluo@vip.sina.com FU US Centers for Disease Control and Prevention's Global Disease Detection and Response Initiative FX Financial support was provided by the Acute Meningitis-Encephalitis Syndrome Surveillance project of US Centers for Disease Control and Prevention's Global Disease Detection and Response Initiative. NR 25 TC 9 Z9 11 U1 0 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2014 VL 20 IS 1 BP 61 EP 69 DI 10.3201/eid2001.120375 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 283UI UT WOS:000329272100009 PM 24377388 ER PT J AU Marini, RP Cassiday, PK Venezia, J Shen, Z Buckley, EM Peters, Y Taylor, N Dewhirst, FE Tondella, ML Fox, JG AF Marini, Robert P. Cassiday, Pamela K. Venezia, Jaime Shen, Zeli Buckley, Ellen M. Peters, Yaicha Taylor, Nancy Dewhirst, Floyd E. Tondella, Maria L. Fox, James G. TI Corynebacterium ulcerans in Ferrets SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID DIPHTHERIAE; MACAQUES; CAT C1 [Marini, Robert P.; Venezia, Jaime; Shen, Zeli; Buckley, Ellen M.; Peters, Yaicha; Taylor, Nancy; Fox, James G.] MIT, Cambridge, MA 02139 USA. [Cassiday, Pamela K.; Tondella, Maria L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dewhirst, Floyd E.] Forsyth Inst, Cambridge, MA USA. [Dewhirst, Floyd E.] Harvard Univ, Sch Dent Med, Boston, MA 02115 USA. RP Fox, JG (reprint author), MIT, Div Comparat Med, Bldg 16-825C,77 Massachusetts Ave, Cambridge, MA 02139 USA. EM jgfox@mit.edu FU NIEHS NIH HHS [P30 ES002109]; NIH HHS [T32 OD010978] NR 10 TC 7 Z9 7 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2014 VL 20 IS 1 BP 159 EP 161 DI 10.3201/eid2001.130675 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 283UI UT WOS:000329272100032 PM 24377676 ER PT J AU Doi, Y O'Hara, JA Lando, JF Querry, AM Townsend, BM Pasculle, AW Muto, CA AF Doi, Yohei O'Hara, Jessica A. Lando, James F. Querry, Ashley M. Townsend, Bethany M. Pasculle, Anthony W. Muto, Carlene A. TI Co-Production of NDM-1 and OXA-232 by Klebsiella pneumoniae SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID METALLO-BETA-LACTAMASE; UNITED-STATES; ENTEROBACTERIACEAE C1 [Doi, Yohei; O'Hara, Jessica A.; Querry, Ashley M.; Townsend, Bethany M.; Pasculle, Anthony W.; Muto, Carlene A.] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15261 USA. [Lando, James F.] Ctr Dis Control & Prevent, Assigned Allegheny Cty Hlth Dept, Pittsburgh, PA USA. RP Doi, Y (reprint author), Univ Pittsburgh, Sch Med, Div Infect Dis, Scaife Hall S829,3550 Terrace St, Pittsburgh, PA 15261 USA. EM yod4@pitt.edu NR 10 TC 19 Z9 19 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2014 VL 20 IS 1 BP 163 EP 165 DI 10.3201/eid2001.130904 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 283UI UT WOS:000329272100034 PM 24377764 ER PT J AU Imanishi, M Anderson, TC Routh, J Brown, C Conidi, G Glenn, L Reddy, V Waechter, H Malavet, M Nyaku, M Bohm, S Bidol, S Arends, K Saupe, A Higa, J Nguyen, TA Pringle, J Behravesh, CB Bosch, S AF Imanishi, Maho Anderson, Tara C. Routh, Janell Brown, Catherine Conidi, Giuseppe Glenn, Lynda Reddy, Vasudha Waechter, HaeNa Malavet, Michelle Nyaku, Mawuli Bohm, Susan Bidol, Sally Arends, Katherine Saupe, Amy Higa, Jeffrey Thai-An Nguyen Pringle, Jeshua Behravesh, Casey Barton Bosch, Stacey TI Salmonellosis and Meat Purchased at Live-Bird and Animal-Slaughter Markets, United States, 2007-2012 SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID AVIAN INFLUENZA C1 [Imanishi, Maho; Anderson, Tara C.; Routh, Janell; Nyaku, Mawuli; Thai-An Nguyen; Pringle, Jeshua; Behravesh, Casey Barton; Bosch, Stacey] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Brown, Catherine; Conidi, Giuseppe; Glenn, Lynda] Massachusetts Dept Publ Hlth, Boston, MA USA. [Reddy, Vasudha; Waechter, HaeNa] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Malavet, Michelle] New Jersey State Dept Hlth, Trenton, NJ 08625 USA. [Nyaku, Mawuli; Bohm, Susan; Bidol, Sally; Arends, Katherine] Michigan Dept Community Hlth, Lansing, MI USA. [Saupe, Amy] Minnesota Dept Hlth, St Paul, MN USA. [Higa, Jeffrey] Calif Dept Publ Hlth, Gardena, CA USA. RP Bosch, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A38, Atlanta, GA 30333 USA. EM gii5@cdc.gov NR 7 TC 5 Z9 5 U1 0 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2014 VL 20 IS 1 BP 167 EP 169 DI 10.3201/eid2001.131179 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 283UI UT WOS:000329272100036 PM 24377875 ER PT J AU Cantonwine, DE Cordero, JF Rivera-Gonzalez, LO Del Toro, LVA Ferguson, KK Mukherjee, B Calafat, AM Crespo, N Jimenez-Velez, B Padilla, IY Alshawabkeh, AN Meeker, JD AF Cantonwine, David E. Cordero, Jose F. Rivera-Gonzalez, Luis O. Del Toro, Liza V. Anzalota Ferguson, Kelly K. Mukherjee, Bhramar Calafat, Antonia M. Crespo, Noe Jimenez-Velez, Braulio Padilla, Ingrid Y. Alshawabkeh, Akram N. Meeker, John D. TI Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Endocrine disruptor; Phthalates; Environment; Epidemiology; Exposure; Pregnancy ID CARE PRODUCT USE; CONSUMER PRODUCTS; BIRTH OUTCOMES; BISPHENOL-A; EXPOSURE; ESTERS; MEN; POPULATION; MONOESTERS; CHEMICALS AB Background: Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, information on exposure to phthalates from a variety of sources in Puerto Rico is lacking. The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico. Methods: We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18 +/- 2 weeks, 22 +/- 2 weeks, and 26 +/- 2 weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP). Results: Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolite concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP). Conclusions: To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Cantonwine, David E.] Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA. [Cordero, Jose F.; Del Toro, Liza V. Anzalota; Crespo, Noe; Jimenez-Velez, Braulio] Univ Puerto Rico, Grad Sch Publ Hlth, San Juan, PR 00936 USA. [Rivera-Gonzalez, Luis O.; Ferguson, Kelly K.; Meeker, John D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Mukherjee, Bhramar] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Padilla, Ingrid Y.] Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR USA. [Alshawabkeh, Akram N.] Northeastern Univ, Coll Engn, Boston, MA 02115 USA. RP Cantonwine, DE (reprint author), Brigham & Womens Hosp, Dept Obstet & Gynecol, MFM Div, Room 304 CWN,75 Francis St, Boston, MA 02115 USA. EM dcantonwine@partners.org OI Meeker, John/0000-0001-8357-5085; Ferguson, Kelly/0000-0001-8467-3250 FU National Institute of Environmental Health Sciences (NIEHS) [P42ES017198, P30ES017885] FX The project described was supported by P42ES017198 and P30ES017885 from the National Institute of Environmental Health Sciences (NIEHS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences, the National Institutes of Health, or the Centers for Disease Control and Prevention. The authors declare no competing financial interests. We gratefully acknowledge Manori Silva, Ella Samandar, Jim Preau, and Tao Jia for technical assistance in measuring the urinary concentrations of the phthalate metabolites. NR 54 TC 39 Z9 39 U1 7 U2 47 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD JAN PY 2014 VL 62 BP 1 EP 11 DI 10.1016/j.envint.2013.09.014 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 280BF UT WOS:000329003000001 PM 24161445 ER PT J AU Grosse, SD Boulet, SL Grant, AM Hulihan, MM Faughnan, ME AF Grosse, Scott D. Boulet, Sheree L. Grant, Althea M. Hulihan, Mary M. Faughnan, Marie E. TI The use of US health insurance data for surveillance of rare disorders: hereditary hemorrhagic telangiectasia SO GENETICS IN MEDICINE LA English DT Article DE administrative data; epidemiology; Osler-Weber-Rendu disease; prevalence ID ARTERIOVENOUS-MALFORMATION; MOLECULAR DIAGNOSIS; POPULATION; EXPENDITURES; MORTALITY; CARE AB Purpose: To assess the utility of US health insurance data for surveillance of hereditary hemorrhagic telangiectasia, an autosomal-dominant blood vasculature disorder with an estimated prevalence of 1.5-2.0 per 10,000 persons worldwide. Methods: We used 2005-2010 MarketScan Research Databases to identify individuals with employer-sponsored health insurance and International Classification of Disease, 9th Revision, Clinical Modification codes of 448.0 present in either one inpatient claim or two outpatient claims 30 days apart to define hereditary hemorrhagic telangiectasia. We examined frequencies of International Classification of Disease, 9th Revision, Clinical Modification codes for conditions that are complications of hereditary hemorrhagic telangiectasia among individuals with hereditary hemorrhagic telangiectasia and the general population to identify combinations of codes associated with hereditary hemorrhagic telangiectasia. Results: Excluding observations from one state, the average prevalence of hereditary hemorrhagic telangiectasia was 0.3 per 10,000 persons. The reported prevalence rose with age from similar to 0.1 per 10,000 at ages <30 years to 1.0-1.1 per 10,000 at ages 70 years and above. The condition codes that were most specific to presumed hereditary hemorrhagic telangiectasia were lung arteriovenous malformations and upper gastrointestinal angiodysplasia. Combinations of those codes and codes for brain arteriovenous malformation and epistaxis were highly predictive of reporting of hereditary hemorrhagic telangiectasia, with 20-57% of enrollees with those codes also meeting the study definition for hereditary hemorrhagic telangiectasia. Conclusion: Hereditary hemorrhagic telangiectasia is underrecognized in US administrative data. Administrative health data can be used to identify individuals with combinations of signs that are suggestive of hereditary hemorrhagic telangiectasia. Studies are needed to test the hypothesis that referral for evaluation of individuals with administrative records suggestive of undiagnosed hereditary hemorrhagic telangiectasia could lead to diagnosis and access to life-saving treatments for both them and affected family members. C1 [Grosse, Scott D.; Grant, Althea M.; Hulihan, Mary M.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Boulet, Sheree L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Faughnan, Marie E.] Univ Toronto, St Michaels Hosp, Dept Med, Toronto HHT Ctr,Div Respirol, Toronto, ON M5B 1W8, Canada. [Faughnan, Marie E.] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Faughnan, Marie E.] HHT Fdn Int, Monkton, MD USA. RP Grosse, SD (reprint author), Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM sgrosse@cdc.gov FU Intramural CDC HHS [CC999999] NR 25 TC 12 Z9 12 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD JAN PY 2014 VL 16 IS 1 BP 33 EP 39 DI 10.1038/gim.2013.66 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 284GO UT WOS:000329304300005 PM 23703685 ER PT J AU Scheuner, MT Hamilton, AB Peredo, J Sale, TJ Austin, C Gilman, SC Bowen, MS Goldzweig, CL Lee, M Mittman, BS Yano, EM AF Scheuner, Maren T. Hamilton, Alison B. Peredo, Jane Sale, Taylor J. Austin, Colletta Gilman, Stuart C. Bowen, M. Scott Goldzweig, Caroline Lubick Lee, Martin Mittman, Brian S. Yano, Elizabeth M. TI A cancer genetics toolkit improves access to genetic services through documentation and use of the family history by primary-care clinicians SO GENETICS IN MEDICINE LA English DT Article DE family history; hereditary cancer; referral ID BRCA2 MUTATION CARRIERS; CONTINUING MEDICAL-EDUCATION; WOMENS HEALTH-CARE; BREAST-CANCER; COLORECTAL-CANCER; LYNCH-SYNDROME; GENOMIC MEDICINE; RISK-ASSESSMENT; OVARIAN-CANCER; DELIVERY AB Purpose: We developed, implemented, and evaluated a multicomponent cancer genetics toolkit designed to improve recognition and appropriate referral of individuals at risk for hereditary cancer syndromes. Methods: We evaluated toolkit implementation in the women's clinics at a large Veterans Administration medical center using mixed methods, including pre-post semistructured interviews, clinician surveys, and chart reviews, and during implementation, monthly tracking of genetic consultation requests and use of a reminder in the electronic health record. We randomly sampled 10% of progress notes 6 months before (n = 139) and 18 months during implementation (n = 677). Results: The toolkit increased cancer family history documentation by almost 10% (26.6% pre- and 36.3% postimplementation). The reminder was a key component of the toolkit; when used, it was associated with a twofold increase in cancer family history documentation (odds ratio = 2.09; 95% confidence interval: 1.39-3.15), and the history was more complete. Patients whose clinicians completed the reminder were twice as likely to be referred for genetic consultation (4.1-9.6%, P < 0.0001). Conclusion: A multicomponent approach to the systematic collection and use of family history by primary-care clinicians increased access to genetic services. C1 [Scheuner, Maren T.; Hamilton, Alison B.; Peredo, Jane; Sale, Taylor J.; Austin, Colletta; Goldzweig, Caroline Lubick; Lee, Martin; Mittman, Brian S.; Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Scheuner, Maren T.; Goldzweig, Caroline Lubick] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Hamilton, Alison B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Gilman, Stuart C.] Vet Hlth Adm, Off Acad Affiliat, Washington, DC USA. [Bowen, M. Scott] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. [Lee, Martin; Yano, Elizabeth M.] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Los Angeles, CA USA. RP Scheuner, MT (reprint author), VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. EM maren.scheuner@va.gov OI Mittman, Brian/0000-0003-3589-9178 FU Centers for Disease Control and Prevention [1U38GD000047] FX This publication was supported by Cooperative Agreement No. 1U38GD000047 from the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. We thank Muin Khoury for his review of the manuscript (he received no compensation), Lisa V. Rubenstein for her input to the study design and review of implementation activities, Shannon Rhodes for data management and preliminary analyses, and Austin Jones for his contributions to data entry and quality assurance. Rubenstein, Rhodes, and Jones provided these services in their respective roles as employees at the VA Greater Los Angeles Healthcare System. NR 38 TC 11 Z9 11 U1 0 U2 8 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD JAN PY 2014 VL 16 IS 1 BP 60 EP 69 DI 10.1038/gim.2013.75 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 284GO UT WOS:000329304300009 PM 23765051 ER PT J AU Grewal, P Kamili, S Motamed, D AF Grewal, Priya Kamili, Saleem Motamed, David TI Chronic Hepatitis E in an Immunocompetent Patient: A Case Report SO HEPATOLOGY LA English DT Article ID E VIRUS-INFECTION C1 [Grewal, Priya; Motamed, David] Mt Sinai Med Ctr, Recanati Miller Transplantat Inst, New York, NY 10029 USA. [Kamili, Saleem] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. RP Grewal, P (reprint author), Mt Sinai Med Ctr, Div Liver Dis, Recanati Miller Transplantat Inst, 1425 Madison Ave,Suite 3-61,Box 1104, New York, NY 10029 USA. EM Priya.grewal@mountsinai.org NR 8 TC 17 Z9 20 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD JAN PY 2014 VL 59 IS 1 BP 347 EP 348 DI 10.1002/hep.26636 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 276GZ UT WOS:000328738400035 PM 23913727 ER PT J AU Banach, DB Francois, J Blash, S Patel, G Jenkins, SG LaBombardi, V Kreiswirth, BN Srinivasan, A Calfee, DP AF Banach, David B. Francois, Jeannette Blash, Stephanie Patel, Gopi Jenkins, Stephen G. LaBombardi, Vincent Kreiswirth, Barry N. Srinivasan, Arjun Calfee, David P. TI Active Surveillance for Carbapenem-Resistant Enterobacteriaceae Using Stool Specimens Submitted for Testing for Clostridium difficile SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID KLEBSIELLA-PNEUMONIAE; ACQUISITION AB Active surveillance to identify asymptomatic carriers of carbapenem-resistant Enterobacteriaceae (CRE) is a recommended strategy for CRE control in healthcare facilities. Active surveillance using stool specimens tested for Clostridium difficile is a relatively low-cost strategy to detect CRE carriers. Further evaluation of this and other risk factor--based active surveillance strategies is warranted. C1 [Banach, David B.; Blash, Stephanie; Patel, Gopi; LaBombardi, Vincent] Mt Sinai Sch Med, New York, NY USA. [Francois, Jeannette] NewYork Presbyterian Hosp, New York, NY USA. [Jenkins, Stephen G.; Calfee, David P.] Weill Cornell Med Coll, New York, NY 10065 USA. [Kreiswirth, Barry N.] Univ Med & Dent New Jersey, Publ Hlth Res Inst, Int Ctr Publ Hlth, Newark, NJ 07103 USA. [Srinivasan, Arjun] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Calfee, DP (reprint author), Weill Cornell Med Coll, 525 East 68th St,Box 265, New York, NY 10065 USA. EM dpc9003@med.cornell.edu FU Association of American Medical Colleges; Centers for Disease Control and Prevention [MM-1085-09/09]; National Institutes of Health [1R01AI090155] FX This study was funded by the Association of American Medical Colleges and the Centers for Disease Control and Prevention (cooperative agreement MM-1085-09/09 to D.P.C.). This study was also supported by a grant (to B.N.K.) from the National Institutes of Health (1R01AI090155). NR 10 TC 5 Z9 5 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JAN 1 PY 2014 VL 35 IS 1 BP 82 EP 84 DI 10.1086/674391 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 272KZ UT WOS:000328460800014 PM 24334803 ER PT J AU Mendonca, K Hauser, R Calafat, AM Arbuckle, TE Duty, SM AF Mendonca, K. Hauser, R. Calafat, A. M. Arbuckle, T. E. Duty, S. M. TI Bisphenol A concentrations in maternal breast milk and infant urine SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH LA English DT Article DE Bisphenol A; Breast milk; Urine; Infant; Exposure ID TANDEM MASS-SPECTROMETRY; HPLC-MS/MS METHOD; ENVIRONMENTAL PHENOLS; EXPOSURE; CHILDREN; BIRTH; VARIABILITY; PREDICTORS; PREGNANCY; CHEMICALS AB The present report describes the distribution of breast milk and urinary free and total bisphenol A (BPA) concentrations, from 27 postpartum women and their 31 infants, and explores the influence of age, sex, and nutritional source on infant BPA urinary concentration. Both free (unconjugated) and total (free plus conjugated) BPA concentrations from women's breast milk samples and infants' urine samples were measured by online solid-phase extraction coupled to high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Descriptive statistics and nonparametric tests of group comparisons were conducted. Total BPA was detected in 93 % of urine samples in this healthy infant population aged 3-15 months who were without known environmental exposure to BPA [interquartile range (IQR) = 1.2-4.4 mu g/L)]. Similarly, 75 % of the mothers' breast milk samples had detectable concentrations of total BPA (IQR = 0.4-1.4 mu g/L). The magnitude and frequency of detection of free BPA in the children's urine and the mothers' breast milk were much lower than the total concentrations. Total BPA was detected in 93 % of this healthy infant population aged 3-15 months who are without known environmental exposure to BPA. Neither free nor total BPA urinary concentrations differed significantly by infant's sex or by nutritional source (breast milk and/or formula) while age group was of borderline significance. There were no significant correlations between free or total BPA concentrations in mothers' breast milk and their infants' urine. C1 [Mendonca, K.; Duty, S. M.] Simmons Coll, Nursing Programs, Sch Nursing & Hlth Sci, Boston, MA 02115 USA. [Hauser, R.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Calafat, A. M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Arbuckle, T. E.] Hlth Canada, Populat Studies Div, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0K9, Canada. RP Duty, SM (reprint author), Simmons Coll, Nursing Programs, Sch Nursing & Hlth Sci, 300 Fenway,Sci Bldg,Room 314, Boston, MA 02115 USA. EM susan.duty@simmons.edu FU Harvard School of Public Health-National Institute of Environmental Health Sciences (HSPH-NIEHS) [P30ES000002] FX Jennifer Ford RN, BSN (Harvard School of Public Health). Dr. Elizabeth Hait, MD (Children's Hospital, Boston, MA). Xiaoyun Ye, Xiaoliu Zhou, Tao Jia, and Amber Bishop (CDC) for the measurements of BPA. The biospecimen analyses were funded under the Government of Canada's Chemicals Management Plan. Kaitlin Mendonca was supported by training grant Harvard School of Public Health-National Institute of Environmental Health Sciences (HSPH-NIEHS) Pilot Grant #P30ES000002. NR 43 TC 26 Z9 28 U1 3 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-0131 EI 1432-1246 J9 INT ARCH OCC ENV HEA JI Int. Arch. Occup. Environ. Health PD JAN PY 2014 VL 87 IS 1 BP 13 EP 20 DI 10.1007/s00420-012-0834-9 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 283GJ UT WOS:000329233900002 PM 23212895 ER PT J AU Carson, PJ Prince, HE Biggerstaff, BJ Lanciotti, R Tobler, LH Busch, M AF Carson, Paul J. Prince, Harry E. Biggerstaff, Brad J. Lanciotti, Robert Tobler, Leslie H. Busch, Michael TI Characteristics of Antibody Responses in West Nile Virus-Seropositive Blood Donors SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID INFECTION; RNA; PROTECTION; SEROLOGY; DISEASE AB West Nile virus (WNV) is now endemic in the United States. Protection against infection is thought to be conferred in part by humoral immunity. An understanding of the durability and specificity of the humoral response is not well established. We studied the magnitude and specificity of antibody responses in 370 WNV-seropositive blood donors. We also recalled 18 donors who were infected in 2005 to compare their antibody responses at 6 months following infection versus at 5 years postinfection. There were no significant differences in IgG antibody levels based on age, sex, or recent infection (as evidenced by IgM positivity). Specific antibody responses by viral plaque reduction neutralization testing (PRNT) were seen in 51/54 subjects evaluated. All donors who were seropositive in 2005 remained seropositive at 5 years and maintained neutralizing antibodies. IgG levels at 5 years postinfection showed fairly minimal decreases compared with the paired levels at 6 months postinfection (mean of paired differences, -0.54 signal-to-cutoff ratio (S/CO) units [95% confidence interval {CI}, -0.86 to -0.21 S/CO units]) and only minimal decreases in PRNT titers. WNV induces a significant antibody response that remains present even 5 years after infection. C1 [Carson, Paul J.] Univ N Dakota, Sch Med, Grand Forks, ND 58202 USA. [Carson, Paul J.] Sanford Hlth, Fargo, ND USA. [Prince, Harry E.] Focus Diagnost, Cypress, CA USA. [Biggerstaff, Brad J.; Lanciotti, Robert] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Tobler, Leslie H.; Busch, Michael] Blood Syst Res Inst, San Francisco, CA USA. RP Carson, PJ (reprint author), Univ N Dakota, Sch Med, Grand Forks, ND 58202 USA. EM paul.carson@sanfordhealth.org FU Centers for Disease Control and Prevention [R01-CI-000214]; National Heart, Lung, and Blood Institute [RC2-HL-101632] FX This work was funded in part by grants from the Centers for Disease Control and Prevention (R01-CI-000214) and the National Heart, Lung, and Blood Institute (RC2-HL-101632). NR 19 TC 7 Z9 7 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2014 VL 52 IS 1 BP 57 EP 60 DI 10.1128/JCM.01932-13 PG 4 WC Microbiology SC Microbiology GA 283CM UT WOS:000329222400010 PM 24131687 ER PT J AU Lu, XY Whitaker, B Sakthivel, SKK Kamili, S Rose, LE Lowe, L Mohareb, E Elassal, EM Al-sanouri, T Haddadin, A Erdman, DD AF Lu, Xiaoyan Whitaker, Brett Sakthivel, Senthil Kumar K. Kamili, Shifaq Rose, Laura E. Lowe, Luis Mohareb, Emad Elassal, Emad M. Al-sanouri, Tarek Haddadin, Aktham Erdman, Dean D. TI Real-Time Reverse Transcription-PCR Assay Panel for Middle East Respiratory Syndrome Coronavirus SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SARS CORONAVIRUS; CLINICAL-FEATURES; INFECTION; PNEUMONIA; PLASMA AB A new human coronavirus (CoV), subsequently named Middle East respiratory syndrome (MERS)-CoV, was first reported in Saudi Arabia in September 2012. In response, we developed two real-time reverse transcription-PCR (rRT-PCR) assays targeting the MERS-CoV nucleocapsid (N) gene and evaluated these assays as a panel with a previously published assay targeting the region upstream of the MERS-CoV envelope gene (upE) for the detection and confirmation of MERS-CoV infection. All assays detected <= 10 copies/reaction of quantified RNA transcripts, with a linear dynamic range of 8 log units and 1.3 x 10(-3) 50% tissue culture infective doses (TCID50)/ml of cultured MERS-CoV per reaction. All assays performed comparably with respiratory, serum, and stool specimens spiked with cultured virus. No false-positive amplifications were obtained with other human coronaviruses or common respiratory viral pathogens or with 336 diverse clinical specimens from non-MERS-CoV cases; specimens from two confirmed MERS-CoV cases were positive with all assay signatures. In June 2012, the U. S. Food and Drug Administration authorized emergency use of the rRT-PCR assay panel as an in vitro diagnostic test for MERS-CoV. A kit consisting of the three assay signatures and a positive control was assembled and distributed to public health laboratories in the United States and internationally to support MERS-CoV surveillance and public health responses. C1 [Lu, Xiaoyan; Whitaker, Brett; Sakthivel, Senthil Kumar K.; Kamili, Shifaq; Erdman, Dean D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Rose, Laura E.; Lowe, Luis] Ctr Dis Control & Prevent, Div Preparedness & Emerging Infect, Atlanta, GA USA. [Mohareb, Emad; Elassal, Emad M.] US Naval Med Res Unit 3, Cairo, Egypt. [Al-sanouri, Tarek; Haddadin, Aktham] Minist Hlth, Cent Publ Hlth Lab, Amman, Jordan. RP Erdman, DD (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. EM dde1@cdc.gov NR 15 TC 37 Z9 42 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2014 VL 52 IS 1 BP 67 EP 75 DI 10.1128/JCM.02533-13 PG 9 WC Microbiology SC Microbiology GA 283CM UT WOS:000329222400012 PM 24153118 ER PT J AU Vega, E Barclay, L Gregoricus, N Shirley, SH Lee, D Vinje, J AF Vega, Everardo Barclay, Leslie Gregoricus, Nicole Shirley, S. Hannah Lee, David Vinje, Jan TI Genotypic and Epidemiologic Trends of Norovirus Outbreaks in the United States, 2009 to 2013 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GII.4 SYDNEY NOROVIRUS; GASTROENTERITIS; STRAIN; SURVEILLANCE; EMERGENCE; SYSTEM; RECOMBINATION; TRANSMISSION; INFECTIONS; EVOLUTION AB Noroviruses are the leading cause of epidemic acute gastroenteritis in the United States. From September 2009 through August 2013, 3,960 norovirus outbreaks were reported to CaliciNet. Of the 2,895 outbreaks with a known transmission route, person-to-person and food-borne transmissions were reported for 2,425 (83.7%) and 465 (16.1%) of the outbreaks, respectively. A total of 2,475 outbreaks (62.5%) occurred in long-term care facilities (LTCF), 389 (9.8%) in restaurants, and 227 (5.7%) in schools. A total of 435 outbreaks (11%) were typed as genogroup I (GI) and 3,525 (89%) as GII noroviruses. GII.4 viruses caused 2,853 (72%) of all outbreaks, of which 94% typed as either GII.4 New Orleans or GII.4 Sydney. In addition, three non-GII.4 viruses, i.e., GII.12, GII.1, and GI.6, caused 528 (13%) of all outbreaks. Several non-GII.4 genotypes (GI.3, GI.6, GI.7, GII.3, GII.6, and GII.12) were significantly more associated with food-borne transmission (odds ratio, 1.9 to 7.1; P < 0.05). Patients in LTCF and people >= 65 years of age were at higher risk for GII.4 infections than those in other settings and with other genotypes (P < 0.05). Phylogeographic analysis identified three major dispersions from two geographic locations that were responsible for the GI.6 outbreaks from 2011 to 2013. In conclusion, our data demonstrate the cyclic emergence of new (non-GII.4) norovirus strains, and several genotypes are more often associated with food-borne outbreaks. These surveillance data can be used to improve viral food-borne surveillance and to help guide studies to develop and evaluate targeted prevention methods such as norovirus vaccines, antivirals, and environmental decontamination methods. C1 [Vega, Everardo; Barclay, Leslie; Gregoricus, Nicole; Shirley, S. Hannah; Lee, David; Vinje, Jan] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Shirley, S. Hannah; Lee, David] Atlanta Res & Educ Fdn, Atlanta, GA USA. RP Vega, E (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM evega@cdc.gov; jvinje@cdc.gov FU intramural food safety program at the Centers for Disease Control and Prevention; Agriculture and Food Research Initiative Competitive from the U. S. Department of Agriculture, National Institute of Food and Agriculture [2011-68003-30395] FX This study was supported by the intramural food safety program at the Centers for Disease Control and Prevention and in part by Agriculture and Food Research Initiative Competitive Grant 2011-68003-30395 from the U. S. Department of Agriculture, National Institute of Food and Agriculture. NR 44 TC 87 Z9 90 U1 4 U2 29 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2014 VL 52 IS 1 BP 147 EP 155 DI 10.1128/JCM.02680-13 PG 9 WC Microbiology SC Microbiology GA 283CM UT WOS:000329222400023 PM 24172151 ER PT J AU Kozak-Muiznieks, NA Lucas, CE Brown, E Pondo, T Taylor, TH Frace, M Miskowski, D Winchell, JM AF Kozak-Muiznieks, Natalia A. Lucas, Claressa E. Brown, Ellen Pondo, Tracy Taylor, Thomas H., Jr. Frace, Michael Miskowski, Diane Winchell, Jonas M. TI Prevalence of Sequence Types among Clinical and Environmental Isolates of Legionella pneumophila Serogroup 1 in the United States from 1982 to 2012 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MONOCLONAL-ANTIBODY SUBGROUPS; LEGIONNAIRES-DISEASE; DISCRIMINATORY ABILITY; STRAINS; SCHEME; WATER; JAPAN; SURVEILLANCE; DIVERSITY; OUTBREAK AB Since the establishment of sequence-based typing as the gold standard for DNA-based typing of Legionella pneumophila, the Legionella laboratory at the Centers for Disease Control and Prevention (CDC) has conducted routine sequence-based typing (SBT) analysis of all incoming L. pneumophila serogroup 1 (Lp1) isolates to identify potential links between cases and to better understand genetic diversity and clonal expansion among L. pneumophila bacteria. Retrospective genotyping of Lp1 isolates from sporadic cases and Legionnaires' disease (LD) outbreaks deposited into the CDC reference collection since 1982 has been completed. For this study, we compared the distribution of sequence types (STs) among Lp1 isolates implicated in 26 outbreaks in the United States, 571 clinical isolates from sporadic cases of LD in the United States, and 149 environmental isolates with no known association with LD. The Lp1 isolates under study had been deposited into our collection between 1982 and 2012. We identified 17 outbreak-associated STs, 153 sporadic STs, and 49 environmental STs. We observed that Lp1 STs from outbreaks and sporadic cases are more similar to each other than either group is to environmental STs. The most frequent ST for both sporadic and environmental isolates was ST1, accounting for 25% and 49% of the total number of isolates, respectively. The STs shared by both outbreak-associated and sporadic Lp1 included ST1, ST35, ST36, ST37, and ST222. The STs most commonly found in sporadic and outbreak-associated Lp1 populations may have an increased ability to cause disease and thus may require special attention when detected. C1 [Kozak-Muiznieks, Natalia A.; Lucas, Claressa E.; Brown, Ellen; Pondo, Tracy; Taylor, Thomas H., Jr.; Winchell, Jonas M.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Frace, Michael] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Miskowski, Diane] EMSL Analyt Inc, Cinnaminson, NJ USA. RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM Jwinchell@cdc.gov FU CDC NCEH/NCZVED Safe Water Foundation FX This work was supported by funding from the CDC NCEH/NCZVED Safe Water Foundation. NR 39 TC 15 Z9 15 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2014 VL 52 IS 1 BP 201 EP 211 DI 10.1128/JCM.01973-13 PG 11 WC Microbiology SC Microbiology GA 283CM UT WOS:000329222400030 PM 24197883 ER PT J AU Donskey, CJ Sunkesula, VCK Jencson, AL Stone, ND Gould, CV McDonald, LC Samore, M Mayer, J Pacheco, S Sambol, S Petrella, L Terry, D Gerding, DN AF Donskey, Curtis J. Sunkesula, Venkata C. K. Jencson, Annette L. Stone, Nimalie D. Gould, Carolyn V. McDonald, L. Clifford Samore, Matthew Mayer, Jeanmarie Pacheco, Susan Sambol, Susan Petrella, Laurica Terry, Deborah Gerding, Dale N. TI Utility of a Commercial PCR Assay and a Clinical Prediction Rule for Detection of Toxigenic Clostridium difficile in Asymptomatic Carriers SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID TERM-CARE FACILITY; HOSPITALIZED-PATIENTS; INFECTION; COLONIZATION; RESIDENTS; TRANSMISSION AB A commercial PCR assay of perirectal swab specimens detected 17 (68%) of 25 asymptomatic carriers of toxigenic Clostridium difficile, including 93% with skin and/or environmental contamination. A clinical prediction rule, followed by PCR screening, could be used to identify carriers at high risk of C. difficile shedding. C1 [Donskey, Curtis J.; Sunkesula, Venkata C. K.; Jencson, Annette L.] Cleveland Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Cleveland, OH 44106 USA. [Stone, Nimalie D.; Gould, Carolyn V.; McDonald, L. Clifford] Ctr Dis Control & Prevent, Atlanta, GA USA. [Samore, Matthew; Mayer, Jeanmarie] Univ Utah, Salt Lake City, UT USA. [Pacheco, Susan; Sambol, Susan; Petrella, Laurica; Terry, Deborah; Gerding, Dale N.] Hines Vet Affairs Hosp, Chicago, IL USA. RP Donskey, CJ (reprint author), Cleveland Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Cleveland, OH 44106 USA. EM curtisd123@yahoo.com; vs123@outlook.com FU Centers for Disease Control and Prevention; Department of Veterans Affairs; ViroPharma; Pfizer; Cubist; GOJO FX This study was supported by the Centers for Disease Control and Prevention and by the Department of Veterans Affairs.; C. J. Donskey is a consultant for GOJO and 3M and has received research grants from ViroPharma, Pfizer, and Cubist. D. N. G. holds patents for the treatment and prevention of CDI licensed to ViroPharma; is a consultant for Sanofi Pasteur, Merck, ViroPharma, GSK, Roche, Novartis, Cubist, Cangene, and Actelion; and holds a research grant from GOJO. NR 14 TC 10 Z9 10 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2014 VL 52 IS 1 BP 315 EP 318 DI 10.1128/JCM.01852-13 PG 4 WC Microbiology SC Microbiology GA 283CM UT WOS:000329222400048 PM 24153132 ER PT J AU Glass, RI Parashar, U Patel, M Gentsch, J Jiang, BM AF Glass, Roger I. Parashar, Umesh Patel, Manish Gentsch, Jon Jiang, Baoming TI Rotavirus vaccines: Successes and challenges SO JOURNAL OF INFECTION LA English DT Article DE Rotavirus; Vaccines; Childhood diarrhea ID CHILDHOOD DIARRHEA; UNITED-STATES; ACUTE GASTROENTERITIS; VACCINATION PROGRAMS; GLOBAL SEASONALITY; YOUNG-CHILDREN; INFECTION; INFANTS; EFFICACY; ANTIBODY AB Since 2006, the availability of two new rotavirus vaccines has raised enthusiasm to consider the eventual control and elimination of severe rotavirus diarrhea through the global use of vaccines. Rotavirus remains the most severe cause of acute diarrhea in children worldwide responsible for several hundred thousands of deaths in low income countries and up to half of hospital admissions for diarrhea around the world. The new vaccines have been recommended by WHO for all infants and in more than 47 countries, their introduction into routine childhood immunization programs has led to a remarkable decline in hospital admissions and even deaths within 3 years of introduction. Challenges remain with issues of vaccine finance globally and the problem that these live oral vaccines perform less well in low income settings where they are needed most. Ongoing research that will accompany vaccine introduction might help address these issues of efficacy and new vaccines and novel financing schemes may both help make these vaccines universally available and affordable in the decade. Published by Elsevier Ltd on behalf of The British Infection Association. C1 [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Parashar, Umesh; Patel, Manish; Gentsch, Jon; Jiang, Baoming] Ctr Dis Control & Prevent, Viral Gastroenteritis Team, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Glass, RI (reprint author), NIH, Fogarty Int Ctr, 31 Ctr Dr,Mailstop 2220, Bethesda, MD 20892 USA. EM glassr@mail.nih.gov; uap2@CDC.GOV; aul3@CDC.GOV; jrg4@CDC.GOV; bxj4@CDC.GOV FU CDC; U.S. Government FX All of this work has been funded through the CDC and the U.S. Government. NR 59 TC 28 Z9 30 U1 2 U2 9 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 EI 1532-2742 J9 J INFECTION JI J. Infect. PD JAN PY 2014 VL 68 SU 1 BP S9 EP S18 DI 10.1016/j.jinf.2013.09.010 PG 10 WC Infectious Diseases SC Infectious Diseases GA 283CN UT WOS:000329222500003 PM 24156947 ER PT J AU Wolter, N Cohen, C Tempia, S Madhi, SA Venter, M Moyes, J Walaza, S Kgokong, BM Groome, M du Plessis, M Pretorius, M Dawood, H Kahn, K Variava, E Klugman, KP von Gottberg, A AF Wolter, Nicole Cohen, Cheryl Tempia, Stefano Madhi, Shabir A. Venter, Marietjie Moyes, Jocelyn Walaza, Sibongile Kgokong, Babatyi Malope Groome, Michelle du Plessis, Mignon Pretorius, Marthi Dawood, Halima Kahn, Kathleen Variava, Ebrahim Klugman, Keith P. von Gottberg, Anne TI HIV and Influenza Virus Infections Are Associated With Increased Blood Pneumococcal Load: A Prospective, Hospital-Based Observational Study in South Africa, 2009-2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Streptococcus pneurnoniae; pneumococcal pneumonia; bacterial load; HIV; influenza ID POLYMERASE-CHAIN-REACTION; COMMUNITY-ACQUIRED PNEUMONIA; GENOMIC BACTERIAL LOAD; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; HEALTHY-CHILDREN; MOUSE MODEL; DISEASE; SAMPLES; IMPACT AB Background. Increased pneumococcal loads are associated with severe outcomes. We determined the prevalence of pneumococcal DNA in blood specimens from patients hospitalized with acute lower respiratory tract infection and identified factors associated with invasive pneumococcal pneumonia, bacterial loads, and death. Methods. A total of 8523 patients were enrolled as part of prospective hospital-based surveillance. Blood was collected for quantitative pneumococcal (tytA) detection, and nasopharyngeal specimens were collected for detection of influenza virus and other respiratory viruses by real-time polymerase chain reaction. Results. Of 6396 cases (75%) with /ytA results, 422 (7%) were positive for pneumococcal DNA. The prevalences of human immunodeficiency virus (HIV) and influenza virus were 51% (2965/5855) and 8% (485/6358), respectively. On multivariable analysis, HIV infection (adjusted odds ratio [aOR], 2.4; 95% confidence interval [CI], 1.6-3.6), influenza virus coinfection (aOR, 1.4; 95% CI, 1.2-2.1), oxygen therapy during admission (a0R, 1.6; 95% CI, 1.1-2.3) and in-hospital death (aOR, 2.1; 95% CI, 1.1-4.0) were significantly associated with increased pneumococcal load. Among /ytA-positive patients, after adjustment for length of hospitalization, duration of symptoms, and oxygen therapy during admission, pneumococcal loads >= 10,000 DNA copies/mi. (a0R, 3.6; 95% CI, 1.8-7.2) were associated with increased risk of death. Conclusions. HIV and influenza virus infections were associated with elevated pneumococcal loads, which, in turn, were associated with increased risk of death. C1 [Wolter, Nicole; Cohen, Cheryl; Tempia, Stefano; Madhi, Shabir A.; Venter, Marietjie; Moyes, Jocelyn; Walaza, Sibongile; Kgokong, Babatyi Malope; du Plessis, Mignon; Pretorius, Marthi; Klugman, Keith P.; von Gottberg, Anne] Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Natl Hlth Lab Serv, ZA-2131 Johannesburg, Gauteng, South Africa. [Wolter, Nicole; Cohen, Cheryl; du Plessis, Mignon; von Gottberg, Anne] Fac Hlth Sci, Johannesburg, South Africa. [Kahn, Kathleen] Univ Witwatersrand, Fac Hlth Sci, MRC, Wits Rural Publ Hlth & Hlth Transit Res Unit Agin, ZA-2050 Johannesburg, South Africa. [Madhi, Shabir A.; Groome, Michelle] Natl Res Fdn Vaccine Preventable Dis, Dept Sci & Technol, Johannesburg, South Africa. [Venter, Marietjie] Univ Pretoria, Dept Med Virol, ZA-0001 Pretoria, South Africa. [Dawood, Halima] Pietermaritzburg Metropolitan Hosp, Edendale Hosp, Pietermaritzburg, South Africa. [Variava, Ebrahim] Klerksdorp Tshepong Hosp, Klerksdorp, South Africa. [Tempia, Stefano] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Klugman, Keith P.] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Klugman, Keith P.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Kahn, Kathleen] Umea Univ, Ctr Global Hlth Res, Umea, Sweden. [Kahn, Kathleen] INDEPTH Network, Accra, Ghana. RP Wolter, N (reprint author), Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM nicolew@nicd.ac.za RI Venter, Marietjie/P-9604-2016; OI Venter, Marietjie/0000-0003-2696-824X; du Plessis, Mignon/0000-0001-9186-0679 FU Pfizer South Africa [WS1167521]; Centers for Disease Control and Prevention [5U51IP0001551] FX This work was supported by Pfizer South Africa (Investigator initiated research agreement WS1167521) and the Centers for Disease Control and Prevention (cooperative agreement 5U51IP0001551). NR 43 TC 9 Z9 9 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2014 VL 209 IS 1 BP 56 EP 65 DI 10.1093/infdis/jit427 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 282FY UT WOS:000329157000010 PM 23922370 ER PT J AU Visser, SN Danielson, ML Bitsko, RH Holbrook, JR Kogan, MD Ghandour, RM Perou, R Blumberg, SJ AF Visser, Susanna N. Danielson, Melissa L. Bitsko, Rebecca H. Holbrook, Joseph R. Kogan, Michael D. Ghandour, Reem M. Perou, Ruth Blumberg, Stephen J. TI Trends in the Parent-Report of Health Care Provider-Diagnosed and Medicated Attention-Deficit/Hyperactivity Disorder: United States, 2003-2011 SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE attention-deficit/hyperactivity disorder (ADHD); epidemiology; medication; prevalence; stimulants ID DEFICIT HYPERACTIVITY DISORDER; SUPPLEMENT NCS-A; SUBSTANCE USE; STIMULANT MEDICATION; MULTIMODAL TREATMENT; TREATMENT STRATEGIES; MENTAL-DISORDERS; CHILDHOOD ADHD; US CHILDREN; FOLLOW-UP AB Objective: Data from the 2003 and 2007 National Survey of Children's Health (NSCH) reflect the increasing prevalence of parent-reported attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment by health care providers. This report updates these prevalence estimates for 2011 and describes temporal trends. Method: Weighted analyses were conducted with 2011 NSCH data to estimate prevalence of parent-reported ADHD diagnosis, current ADHD, current medication treatment, ADHD severity, and mean age of diagnosis for U.S. children/adolescents aged 4 to 17 years and among demographic subgroups. A history of ADHD diagnosis (2003-2011), as well as current ADHD and medication treatment prevalence (2007-2011), were compared using prevalence ratios and 95% confidence intervals. Results: In 2011, 11% of children/adolescents aged 4 to 17 years had ever received an ADHD diagnosis (6.4 million children). Among those with a history of ADHD diagnosis, 83% were reported as currently having ADHD (8.8%); 69% of children with current ADHD were taking medication for ADHD (6.1%, 3.5 million children). A parent-reported history of ADHD increased by 42% from 2003 to 2011. Prevalence of a history of ADHD, current ADHD, medicated ADHD, and moderate/severe ADHD increased significantly from 2007 estimates. Prevalence of medicated ADHD increased by 28% from 2007 to 2011. Conclusions: Approximately 2 million more U.S. children/adolescents aged 4 to 17 years had been diagnosed with ADHD in 2011, compared to 2003. More than two-thirds of those with current ADHD were taking medication for treatment in 2011. This suggests an increasing burden of ADHD on the U.S. health care system. Efforts to further understand ADHD diagnostic and treatment patterns are warranted. J. Am. Acad. Child Adolesc. Psychiatry, 2014;53(1)34-46. C1 [Visser, Susanna N.; Danielson, Melissa L.; Bitsko, Rebecca H.; Holbrook, Joseph R.; Perou, Ruth] Ctr Dis Control & Prevent CDC, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30329 USA. [Kogan, Michael D.; Ghandour, Reem M.] US Hlth Resources & Serv Adm, Off Epidemiol & Res, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Blumberg, Stephen J.] CDC, Div Hlth Interview Stat, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. RP Visser, SN (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, E-88,1600 Clifton Rd, Atlanta, GA 30333 USA. EM svisser@cdc.gov OI Danielson, Melissa/0000-0001-9461-0341 FU Maternal and Child Health Bureau of the Health Resources and Services Administration FX The National Survey of Children's Health is a module of the Centers for Disease Control and Prevention's State and Local Area Integrated Telephone Survey and was sponsored by the Maternal and Child Health Bureau of the Health Resources and Services Administration. NR 56 TC 154 Z9 155 U1 2 U2 41 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0890-8567 EI 1527-5418 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD JAN PY 2014 VL 53 IS 1 BP 34 EP 46 DI 10.1016/j.jaac.2013.09.001 PG 13 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA 280GG UT WOS:000329016100006 PM 24342384 ER PT J AU Alymova, IV Samarasinghe, A Vogel, P Green, AM Weinlich, R McCullers, JA AF Alymova, Irina V. Samarasinghe, Amali Vogel, Peter Green, Amanda M. Weinlich, Ricardo McCullers, Jonathan A. TI A Novel Cytotoxic Sequence Contributes to Influenza A Viral Protein PB1-F2 Pathogenicity and Predisposition to Secondary Bacterial Infection SO JOURNAL OF VIROLOGY LA English DT Article ID CELL-SPECIFIC PROTEIN; VIRUS PROTEIN; MITOCHONDRIAL-MEMBRANE; DIFFERENT STRAINS; INTERFERON; EXPRESSION; PNEUMONIA AB Enhancement of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2. Comparing the sequences (amino acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides from influenza A viruses inducing high or low levels of cell death, we identified a unique I68, L69, and V70 motif in A/Puerto Rico/8/34 PB1-F2 responsible for promotion of the peptide's cytotoxicity and permeabilization of the mitochondrial membrane. When administered to mice, a 27-mer PB1-F2-derived C-terminal peptide with this amino acid motif caused significantly greater weight loss and pulmonary inflammation than the peptide without it (due to I68T, L69Q, and V70G mutations). Similar to the wild-type peptide, A/Puerto Rico/8/34 elicited significantly higher levels of macrophages, neutrophils, and cytokines in the bronchoalveolar lavage fluid of mice than its mutant counterpart 7 days after infection. Additionally, infection of mice with A/Puerto Rico/8/34 significantly enhanced the levels of morphologically transformed epithelial and immune mononuclear cells recruited in the airways compared with the mutant virus. In the mouse bacterial superinfection model, both peptide and virus with the I68, L69, and V70 sequence accelerated development of pneumococcal pneumonia, as reflected by increased levels of viral and bacterial lung titers and by greater mortality. Here we provide evidence suggesting that the newly identified cytotoxic sequence I68, L69, and V70 of A/Puerto Rico/8/34 PB1-F2 contributes to the pathogenesis of both primary viral and secondary bacterial infections. C1 [Alymova, Irina V.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. [Alymova, Irina V.; Green, Amanda M.; McCullers, Jonathan A.] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA. [Vogel, Peter] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA. [Weinlich, Ricardo] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA. [Samarasinghe, Amali; McCullers, Jonathan A.] Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA. RP Alymova, IV (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. EM ialymova@cdc.gov RI Weinlich, Ricardo/S-7495-2016; OI Samarasinghe, Amali/0000-0002-3104-2823 FU American Lebanese Syrian Associated Charities (ALSAC) FX This work was supported by the American Lebanese Syrian Associated Charities (ALSAC). NR 34 TC 15 Z9 15 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2014 VL 88 IS 1 BP 503 EP 515 DI 10.1128/JVI.01373-13 PG 13 WC Virology SC Virology GA 282SW UT WOS:000329194600046 PM 24173220 ER PT J AU Michael, SL Wentzel, K Elliott, MN Dittus, PJ Kanouse, DE Wallander, JL Pasch, KE Franzini, L Taylor, WC Qureshi, T Franklin, FA Schuster, MA AF Michael, Shannon L. Wentzel, Kathryn Elliott, Marc N. Dittus, Patricia J. Kanouse, David E. Wallander, Jan L. Pasch, Keryn E. Franzini, Luisa Taylor, Wendell C. Qureshi, Tariq Franklin, Frank A. Schuster, Mark A. TI Parental and Peer Factors Associated with Body Image Discrepancy among Fifth-Grade Boys and Girls SO JOURNAL OF YOUTH AND ADOLESCENCE LA English DT Article DE Body image discrepancy; Peer factors; Parental factors; Self-worth; Fifth graders ID QUALITY-OF-LIFE; SELF-ESTEEM; ADOLESCENT GIRLS; MEDIA INFLUENCES; PREADOLESCENT CHILDREN; 12-YEAR-OLD GIRLS; WEIGHT STATUS; RISK-FACTORS; MASS INDEX; DISSATISFACTION AB Many young adolescents are dissatisfied with their body due to a discrepancy between their ideal and actual body size, which can lead to weight cycling, eating disorders, depression, and obesity. The current study examined the associations of parental and peer factors with fifth-graders' body image discrepancy, physical self-worth as a mediator between parental and peer factors and body image discrepancy, and how these associations vary by child's sex. Body image discrepancy was defined as the difference between young adolescents' self-perceived body size and the size they believe a person their age should be. Data for this study came from Healthy Passages, which surveyed 5,147 fifth graders (51 % females; 34 % African American, 35 % Latino, 24 % White, and 6 % other) and their primary caregivers from the United States. Path analyses were conducted separately for boys and girls. The findings for boys suggest father nurturance and getting along with peers are related negatively to body image discrepancy; however, for girls, fear of negative evaluation by peers is related positively to body image discrepancy. For both boys and girls, getting along with peers and fear of negative evaluation by peers are related directly to physical self-worth. In addition, mother nurturance is related positively to physical self-worth for girls, and father nurturance is related positively to physical self-worth for boys. In turn, physical self-worth, for both boys and girls, is related negatively to body image discrepancy. The findings highlight the potential of parental and peer factors to reduce fifth graders' body image discrepancy. C1 [Michael, Shannon L.; Qureshi, Tariq] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Michael, Shannon L.; Wentzel, Kathryn] Univ Maryland, College Pk, MD 20742 USA. [Elliott, Marc N.; Kanouse, David E.] RAND Corp, Santa Monica, CA 90407 USA. [Dittus, Patricia J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Wallander, Jan L.] Univ Calif, Merced, CA 95343 USA. [Pasch, Keryn E.] Univ Texas Austin, Austin, TX 78712 USA. [Franzini, Luisa; Taylor, Wendell C.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Franklin, Frank A.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Schuster, Mark A.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Schuster, Mark A.] Childrens Hosp, Dept Med, Div Gen Pediat, Boston, MA 02115 USA. RP Michael, SL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,MS K-12, Atlanta, GA 30341 USA. EM sot2@cdc.gov; wentzel@umd.edu; Marc_Elliott@rand.org; pdittus@cdc.gov; kanouse@rand.org; jwallander@ucmerced.edu; kpasch@austin.utexas.edu; luisa.franzini@uth.tmc.edu; Wendell.C.Taylor@uth.tmc.edu; tq@tariqq.com; FFranklin@ms.soph.uab.edu; mark.schuster@childrens.harvard.edu RI Johnson, Marilyn/E-7209-2011 FU Intramural CDC HHS [CC999999] NR 62 TC 5 Z9 7 U1 2 U2 34 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0047-2891 EI 1573-6601 J9 J YOUTH ADOLESCENCE JI J. Youth Adolesc. PD JAN PY 2014 VL 43 IS 1 BP 15 EP 29 DI 10.1007/s10964-012-9899-8 PG 15 WC Psychology, Developmental SC Psychology GA 283JB UT WOS:000329241200002 PM 23334988 ER PT J AU Almeida, J Mulready-Ward, C Bettegowda, VR Ahluwalia, IB AF Almeida, Joanna Mulready-Ward, Candace Bettegowda, Vani R. Ahluwalia, Indu B. TI Racial/Ethnic and Nativity Differences in Birth Outcomes Among Mothers in New York City: The Role of Social Ties and Social Support SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Low birth weight; Preterm birth; Race/ethnicity; Immigrants; Social ties; Social support ID EPIDEMIOLOGIC PARADOX; PREGNANCY OUTCOMES; HEALTH BEHAVIORS; UNITED-STATES; FOREIGN-BORN; PERINATAL HEALTH; MEXICAN DESCENT; WEIGHT; WOMEN; ACCULTURATION AB Immigrants have lower rates of low birth weight (LBW) and to some extent preterm birth (PTB), than their US-born counterparts. This pattern has been termed the 'immigrant health paradox'. Social ties and support are one proposed explanation for this phenomenon. We examined the contribution of social ties and social support to LBW and PTB by race/ethnicity and nativity among women in New York City (NYC). The NYC Pregnancy Risk Assessment Monitoring System survey (2004-2007) data, linked with the selected items from birth certificates, were used to examine LBW and PTB by race/ethnicity and nativity status and the role of social ties and social support to adverse birth outcomes using bivariate and multivariable analyses. SUDAAN software was used to adjust for complex survey design and sampling weights. US- and foreign-born Blacks had significantly increased odds of PTB [adjusted odds ratio (AOR) = 2.43, 95 % CI 1.56, 3.77 and AOR = 2.6, 95 % CI 1.66, 4.24, respectively] compared to US-born Whites. Odds of PTB among foreign-born Other Latinas, Island-born Puerto Ricans' and foreign-born Asians' were not significantly different from US-born Whites, while odds of PTB for foreign-born Whites were significantly lower (AOR = 0.47, 95 % CI 0.26, 0.84). US and foreign-born Blacks' odds of LBW were 2.5 fold that of US-born Whites. Fewer social ties were associated with 32-39 % lower odds of PTB. Lower social support was associated with decreased odds of LBW (AOR 0.69, 95 % CI 0.50, 0.96). We found stronger evidence of the immigrant health paradox across racial/ethnic groups for PTB than for LBW. Results also point to the importance of accurately assessing social ties and social support during pregnancy and to considering the potential downside of social ties. C1 [Almeida, Joanna] Simmons Sch Social Work, Boston, MA USA. [Mulready-Ward, Candace] Bur Maternal Infant & Reprod Hlth, NYC Dept Hlth & Mental Hyg, New York, NY USA. [Bettegowda, Vani R.] March Dimes Fdn, Perinatal Data Ctr, White Plains, NY USA. [Ahluwalia, Indu B.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Almeida, J (reprint author), Simmons Sch Social Work, Boston, MA USA. EM joanna.almeida@simmons.edu NR 50 TC 4 Z9 4 U1 2 U2 9 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2014 VL 18 IS 1 BP 90 EP 100 DI 10.1007/s10995-013-1238-5 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 283MG UT WOS:000329249600011 PM 23435918 ER PT J AU Smith, JJ Robinson, RF Khan, BA Sosnoff, CS Dillard, DA AF Smith, Julia J. Robinson, Renee F. Khan, Burhan A. Sosnoff, Connie S. Dillard, Denise A. TI Estimating Cotinine Associations and a Saliva Cotinine Level to Identify Active Cigarette Smoking in Alaska Native Pregnant Women SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Maternal cigarette smoking; Pregnant women; Saliva cotinine; Alaska native women ID TANDEM MASS-SPECTROMETRY; SELF-REPORTED SMOKING; TOBACCO-SMOKE; SERUM COTININE; UNITED-STATES; MATERNAL SMOKING; PASSIVE SMOKING; EXPOSURE; NONSMOKERS; NICOTINE AB Studies indicate nicotine metabolism varies by race and can change during pregnancy. Given high rates of tobacco use and limited studies among Alaska Native (AN) women, we estimated associations of saliva cotinine levels with cigarette use and second-hand smoke (SHS) exposure and estimated a saliva cotinine cutoff to distinguish smoking from non-smoking pregnant AN women. Using questionnaire data and saliva cotinine, we utilized multi-variable linear regression (n = 370) to estimate cotinine associations with tobacco use, SHS exposure, demographic, and pregnancy-related factors. Additionally, we estimated an optimal saliva cotinine cutoff for indication of active cigarette use in AN pregnant women using receiver operating characteristic (ROC) curve analysis (n = 377). Saliva cotinine significantly decreased with maternal age and significantly increased with cigarettes smoked per day, SHS exposure, and number of previous full term pregnancies. Using self-reported cigarette use in the past 7 days as indication of active smoking, the area under the ROC curve was 0.975 (95 % CI: 0.960-0.990). The point closest to 100 % specificity and sensitivity occurred with a cotinine concentration of 1.07 ng/mL, which corresponded to sensitivity of 94 % and specificity of 94 %. We recommend using a saliva cotinine cutoff of 1 ng/mL to distinguish active smoking in pregnant AN women. This cutoff is lower than used in other studies with pregnant women, most likely due to high prevalence of light or intermittent smoking in the AN population. Continued study of cotinine levels in diverse populations is needed. C1 [Smith, Julia J.; Robinson, Renee F.; Khan, Burhan A.; Dillard, Denise A.] Southcent Fdn Res Dept, Anchorage, AK 99501 USA. [Sosnoff, Connie S.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA 30341 USA. RP Smith, JJ (reprint author), Southcent Fdn Res Dept, 4501 Diplomacy Dr,Suite 200, Anchorage, AK 99501 USA. EM jsmith@southcentralfoundation.com NR 52 TC 2 Z9 2 U1 0 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2014 VL 18 IS 1 BP 120 EP 128 DI 10.1007/s10995-013-1241-x PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 283MG UT WOS:000329249600014 PM 23423858 ER PT J AU Klein, EG Liu, ST Conrey, EJ AF Klein, Elizabeth G. Liu, Sherry T. Conrey, Elizabeth J. TI Comprehensive Smoke-Free Policies: A Tool for Improving Preconception Health? SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Smoking; Policy; Low-income; Women; WIC; Preconception health ID UNITED-STATES; TOBACCO USE; PRENATAL SMOKING; PREGNANT SMOKERS; SECONDHAND SMOKE; WOMEN; CESSATION; CARE; INDICATORS; TRENDS AB Lower income women are at higher risk for preconception and prenatal smoking, are less likely to spontaneously quit smoking during pregnancy, and have higher prenatal relapse rates than women in higher income groups. Policies prohibiting tobacco smoking in public places are intended to reduce exposure to secondhand smoke; additionally, since these policies promote a smoke-free norm, there have been associations between smoke-free policies and reduced smoking prevalence. Given the public health burden of smoking, particularly among women who become pregnant, our objective was to assess the impact of smoke-free policies on the odds of preconception smoking among low-income women. We estimated the odds of preconception smoking among low-income women in Ohio between 2002 and 2009 using data from repeated cross-sectional samples of women participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). A logistic spline regression was applied fitting a knot at the point of enforcement of the Ohio Smoke-free Workplace Act to evaluate whether this policy was associated with changes in the odds of smoking. After adjusting for individual- and environmental-level factors, the Ohio Smoke-free Workplace Act was associated with a small, but statistically significant reduction in the odds of preconception smoking in WIC participants. Comprehensive smoke-free policies prohibiting smoking in public places and workplaces may also be associated with reductions in smoking among low-income women. This type of policy or environmental change strategy may promote a tobacco-free norm and improve preconception health among a population at risk for smoking. C1 [Klein, Elizabeth G.; Liu, Sherry T.] Ohio State Univ, Coll Publ Hlth, Div Hlth Behav & Hlth Promot, Columbus, OH 43210 USA. [Conrey, Elizabeth J.] Ohio Dept Hlth, State Epidemiol Off, Columbus, OH 43266 USA. [Conrey, Elizabeth J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Klein, EG (reprint author), Ohio State Univ, Coll Publ Hlth, Div Hlth Behav & Hlth Promot, Columbus, OH 43210 USA. EM eklein@cph.osu.edu RI Klein, Elizabeth/B-3195-2012 OI Klein, Elizabeth/0000-0002-6895-4682 NR 43 TC 2 Z9 2 U1 1 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2014 VL 18 IS 1 BP 146 EP 152 DI 10.1007/s10995-013-1247-4 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 283MG UT WOS:000329249600017 PM 23467844 ER PT J AU King, JP Gazmararian, JA Shapiro-Mendoza, CK AF King, Jennifer P. Gazmararian, Julie A. Shapiro-Mendoza, Carrie K. TI Disparities in Mortality Rates Among US Infants Born Late Preterm or Early Term, 2003-2005 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Infant mortality; Preterm infants; Disparities; Vital statistics ID UNITED-STATES; NEONATAL-MORTALITY; SINGLETON BIRTHS; GESTATIONAL-AGE; MATERNAL AGE; RISK; TRENDS; RACE; PREGNANCY; OUTCOMES AB The purpose of this study was to identify disparities in neonatal, post-neonatal, and overall infant mortality rates among infants born late preterm (34-36 weeks gestation) and early term (37-38 weeks gestation) by race/ethnicity, maternal age, and plurality. In analyses of 2003-2005 data from US period linked birth/infant death datasets, we compared infant mortality rates by race/ethnicity, maternal age, and plurality among infants born late preterm or early term and also determined the leading causes of death among these infants. Among infants born late preterm, infants born to American Indian/Alaskan Native, non-Hispanic black, or teenage mothers had the highest infant mortality rates per 1,000 live births (14.85, 9.90, and 11.88 respectively). Among infants born early term, corresponding mortality rates were 5.69, 4.49, and 4.82, respectively. Among infants born late preterm, singletons had a higher infant mortality rate than twins (8.59 vs. 5.62), whereas among infants born early term, the rate was higher among twins (3.67 vs. 3.15). Congenital malformations and sudden infant death syndrome were the leading causes of death among both late preterm and early term infants. Infant mortality rates among infants born late preterm or early term varied substantially by maternal race/ethnicity, maternal age, and plurality. Information about these disparities may help in the development of clinical practice and prevention strategies targeting infants at highest risk. C1 [King, Jennifer P.; Gazmararian, Julie A.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [King, Jennifer P.] Marshfield Med Res Fdn, Epidemiol Res Ctr, Marshfield, WI 54449 USA. [Shapiro-Mendoza, Carrie K.] Ctr Dis Control & Prevent, Maternal & Infant Hlth Branch, Div Reprod Hlth, Atlanta, GA 30341 USA. RP King, JP (reprint author), Marshfield Med Res Fdn, Epidemiol Res Ctr, 1000N Oak Ave ML2, Marshfield, WI 54449 USA. EM king.jennifer@marshfieldclinic.org; jagazma@emory.edu; ayn9@cdc.gov FU Intramural CDC HHS [CC999999] NR 33 TC 4 Z9 5 U1 1 U2 11 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2014 VL 18 IS 1 BP 233 EP 241 DI 10.1007/s10995-013-1259-0 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 283MG UT WOS:000329249600026 PM 23519825 ER PT J AU Kulcsar, M Gilchrist, S George, MG AF Kulcsar, Michael Gilchrist, Siobhan George, Mary G. TI Improving Stroke Outcomes in Rural Areas Through Telestroke Programs: An Examination of Barriers, Facilitators, and State Policies SO TELEMEDICINE AND E-HEALTH LA English DT Article DE telemedicine; telestroke; rural; stroke ID ACUTE ISCHEMIC-STROKE; AMERICAN-HEART-ASSOCIATION; UNITED-STATES; PLASMINOGEN-ACTIVATOR; POOLED ANALYSIS; TELEMEDICINE; CARE; DELIVERY; RECOMMENDATIONS; THROMBOLYSIS AB Introduction:Every year in the United States more than 600,000 ischemic stroke patients do not receive proven, effective stroke treatment or may not be medically eligible to receive the one medication endorsed by the U.S. Food and Drug Administration for acute ischemic stroke. The lack of treatment is due partly to shortages of neurological experts in rural and underserved areas. Telestroke programs can improve stroke care for stroke patients in rural and underserved settings by using interactive telecommunication technology that connects centrally located neurological experts to rural healthcare facilities. Many states have enacted policies and practices that facilitate telestroke access.Materials and Methods:We reviewed statutes and regulations in all 50 states that affect the adoption of telemedicine programs and describe examples of state-implemented programs in two states with policies that encourage telestroke use.Results and Discussion:This review presents evidence of the value and effectiveness of telestroke programs, as well as an explanation of common barriers and facilitators of telestroke, including licensing and credentialing rules, reimbursement issues, and liability concerns. Most states have adopted policies that affect the adoption of telestroke programs. Georgia and South Carolina are examples of states implementing stroke policies using a telestroke model to treat stroke patients in rural areas. C1 [Kulcsar, Michael] Fulton Cty Juvenile Court, Atlanta, GA USA. [Gilchrist, Siobhan] Columbus Technol & Serv Inc, Chamblee, GA USA. [George, Mary G.] Ctr Dis Control & Prevent CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP George, MG (reprint author), Ctr Dis Control & Prevent CDC, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,MS F72, Atlanta, GA 30341 USA. EM coq5@cdc.gov NR 35 TC 2 Z9 2 U1 2 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 EI 1556-3669 J9 TELEMED E-HEALTH JI Telemed. e-Health PD JAN 1 PY 2014 VL 20 IS 1 BP 3 EP 10 DI 10.1089/tmj.2013.0048 PG 8 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 282HV UT WOS:000329162700002 PM 24286197 ER PT J AU Collard, JM Wang, X Mahamane, AE Idi, I Issaka, B Ousseni, M Mayer, LW Nato, F Moulia-Pelat, JP AF Collard, Jean-Marc Wang, Xin Mahamane, Ali Elhaj Idi, Issa Issaka, Bassira Ousseni, Moumouni Mayer, Leonard W. Nato, Farida Moulia-Pelat, Jean-Paul TI A five-year field assessment of rapid diagnostic tests for meningococcal meningitis in Niger by using the combination of conventional and real-time PCR assays as a gold standard SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Early detection; Meningitis; Neisseria meningitidis serogroups A and W; Niger; Patient treatment; Rapid diagnostic tests ID NEISSERIA-MENINGITIDIS; BACTERIAL-MENINGITIS; SEROGROUP-A; IDENTIFICATION; AGREEMENT; AFRICA; W135 AB Meningococcocal meningitis represents an important cause of mortality and morbidity in sub-Saharan countries. Confirmatory bacteriological or molecular diagnosis is essential for patient management/treatment and meningitis surveillance, but many laboratory tests are expensive and rarely available for low-income countries. A rapid diagnostic test (RDT) represents a valuable alternative to improve case management and surveillance. A dipstick RDT developed in early 2000s that detects Neisseria meningitidis serogroups A, C, W and Y but for which a new conjugated antibody (L4-8) for the detection of serogroup A replaced the original K15-2 was assessed in the field by trained staff from health centres and district hospitals in Niger. The results were compared to those obtained in the reference laboratory and the sensitivity and specificity of RDTs were determined using conventional and real-time PCR assays as a gold standard. RDT results from field staff and the reference laboratory obtained for 2095 cerebrospinal fluid (CSF) specimens presented a strong concordance of 94 with Cohens coefficient of 0.88. The observed concordance between RDTs operated by staff from the reference laboratory vs combination of conventional and real-time PCR assays was 89 with Cohens coefficient of 0.76 indicating very good agreement. The theoretical overall sensitivity for RDT was 91.5 and the specificity 84.6. RDT has proven to be relatively sensitive and specific for the detection of meningococcal serogroups A/C/Y/W. We confirmed that these RDTs can be reliably operated by trained but non-specialised staff in basic health facilities. C1 [Collard, Jean-Marc; Mahamane, Ali Elhaj; Idi, Issa; Issaka, Bassira; Ousseni, Moumouni; Moulia-Pelat, Jean-Paul] Ctr Rech Med & Sanit CERMES, Niamey, Niger. [Wang, Xin; Mayer, Leonard W.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA. [Nato, Farida] Inst Pasteur, Platform Recombinant Prot & Antibody Prod PT5, Paris, France. RP Collard, JM (reprint author), Sci Inst Publ Hlth, Brussels, Belgium. EM Jean-Marc.Collard@wiv-isp.be FU French Ministry of Foreign Affairs [FSP] [2005-174]; Sanofi Pasteur [Men07]; UNICEF (RDT distribution and training) FX This work was financially supported by the French Ministry of Foreign Affairs [FSP No. 2005-174] by Sanofi Pasteur [contract Men07] and UNICEF (RDT distribution and training in 2009). NR 29 TC 5 Z9 6 U1 1 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 EI 1878-3503 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JAN PY 2014 VL 108 IS 1 BP 6 EP 12 DI 10.1093/trstmh/trt104 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 281WR UT WOS:000329132200003 PM 24300442 ER PT J AU Costa, F Porter, FH Rodrigues, G Farias, H de Faria, MT Wunder, EA Osikowicz, LM Kosoy, MY Reis, MG Ko, AI Childs, JE AF Costa, Federico Porter, Fleur Helena Rodrigues, Gorete Farias, Helena de Faria, Marcus Tucunduva Wunder, Elsio A. Osikowicz, Lynn M. Kosoy, Michael Y. Reis, Mitermayer Galvao Ko, Albert I. Childs, James E. TI Infections by Leptospira interrogans, Seoul Virus, and Bartonella spp. Among Norway Rats (Rattus norvegicus) from the Urban Slum Environment in Brazil SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Leptospira interrogans; Seoul virus; Bartonella spp; Norway rats (Rattus norvegicus); Brazil ID HANTAVIRUS PULMONARY SYNDROME; RODENTS; POPULATION; BALTIMORE; ZOONOSES; EPIDEMIC; THAILAND; MARYLAND; CITY; USA AB Norway rats (Rattus norvegicus) are reservoir hosts for zoonotic pathogens that cause significant morbidity and mortality in humans. Studies evaluating the prevalence of zoonotic pathogens in tropical Norway rat populations are rare, and data on co-infection with multiple pathogens are nonexistent. Herein, we describe the prevalence of leptospiral carriage, Seoul virus (SEOV), and Bartonella spp. infection independently, in addition to the rates of co-infection among urban, slum-dwelling Norway rats in Salvador, Brazil, trapped during the rainy season from June to August of 2010. These data were complemented with previously unpublished Leptospira and SEOV prevalence information collected in 1998. Immunofluorescence staining of kidney impressions was used to identify Leptospira interrogans in 2010, whereas isolation was used in 1998, and western blotting was used to detect SEOV antibodies in 2010, whereas enzyme-linked immunosorbent assay (ELISA) was used in 1998: in 2010, Bartonella spp. were isolated from a subsample of rats. The most common pathogen in both years was Leptospira spp. (83%, n=142 in 1998, 63%, n=84 in 2010). SEOV was detected in 18% of individuals in both 1998 and 2010 (n=78 in 1998; n=73 in 2010), and two species of Bartonella were isolated from 5 of 26 rats (19%) tested in 2010. The prevalence of all agents increased significantly with rat mass/age. Acquisition of Leptospira spp. occurred at a younger mass/age than SEOV and Bartonella spp. infection, suggesting differences in the transmission dynamics of these pathogens. These data indicate that Norway rats in Salvador serve as reservoir hosts for all three of these zoonotic pathogens and that the high prevalence of leptospiral carriage in Salvador rats poses a high degree of risk to human health. C1 [Costa, Federico; Reis, Mitermayer Galvao] Minist Saude, Ctr Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, BR-40296710 Salvador, BA, Brazil. [Costa, Federico; Porter, Fleur Helena; Wunder, Elsio A.; Ko, Albert I.] Yale Univ, Div Epidemiol Microbial Dis, Sch Publ Hlth, New Haven, CT USA. [Rodrigues, Gorete; Farias, Helena] Minist Saude, Ctr Controle Zoonoses, Secretaria Municipal Saude, Salvador, BA, Brazil. [de Faria, Marcus Tucunduva] Embrapa Amazonia Orienta, Belem, Para, Brazil. [Osikowicz, Lynn M.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, DVBID, Ft Collins, CO USA. [Childs, James E.] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA. [Childs, James E.] Yale Univ, Sch Med, Ctr Ecoepidemiol, New Haven, CT USA. RP Costa, F (reprint author), Minist Saude, Ctr Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Rua Waldemar Falcao 121, BR-40296710 Salvador, BA, Brazil. RI Ko, Albert/P-2343-2015; Wunder, Elsio/C-2733-2013; Costa, Federico/G-1838-2015 OI Costa, Federico/0000-0001-6951-2336 FU Secretariat of Health Surveillance; Oswaldo Cruz Foundation; National Institutes of Health [R01 AI052473, U01 AI088752, R01 TW009504, R24 TW007988, R25 TW009338, D43 TW00919]; CAPES (Coordination for the Improvement of Higher Education Personnel/Ministry of Education/Brazil) FX We would like to thank the staff of Centro de Controle de Zoonoses from Salvador for their assistance in conducting the study and Julia Schoen for assisting with database management; Ying Bai for the Bartonella spp. sequencing; and Kate Hacker for her critical advice during the preparation of the manuscript. This work was supported by the Secretariat of Health Surveillance, the Oswaldo Cruz Foundation and the National Institutes of Health (grants R01 AI052473, U01 AI088752, R01 TW009504, R24 TW007988, R25 TW009338 and D43 TW00919) and CAPES (Coordination for the Improvement of Higher Education Personnel/Ministry of Education/Brazil). NR 54 TC 19 Z9 21 U1 0 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2014 VL 14 IS 1 BP 33 EP 40 DI 10.1089/vbz.2013.1378 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 284ZE UT WOS:000329360400004 PM 24359425 ER PT J AU Lubelczyk, C Elias, SP Kantar, L Albert, J Hansen, S Saxton-Shaw, K MacMillan, K Smith, LB Eisen, R Swope, B Smith, RP Mutebi, JP AF Lubelczyk, Charles Elias, Susan P. Kantar, Lee Albert, Jennifer Hansen, Stephen Saxton-Shaw, Kali MacMillan, Katharine Smith, Leticia B. Eisen, Rebecca Swope, Bethany Smith, Robert Pease Mutebi, John-Paul TI Detection of Eastern Equine Encephalitis Virus Antibodies in Moose (Alces americana), Maine, 2010 SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Eastern equine encephalitis virus; Moose; Alces Americana; Maine; Mosquitos ID WHITE-TAILED DEER; NORTHEASTERN UNITED-STATES; ENCEPHALOMYELITIS; MOSQUITOS; TRANSMISSION; CONNECTICUT; BLOODMEALS; MICHIGAN; OUTBREAK; VECTORS AB Moose sera were collected from harvested animals during the 2010 hunting season in Maine. Of the 145 serum samples screened by plaque reduction neutralization test (PRNT), 16 (11%) had antibodies to eastern equine encephalitis virus (EEEV). Positive samples were collected from Aroostook County (n=13), Somerset County (n=2), and Piscataquis County (n=1) in northern and central Maine. Preliminary mosquito surveillance revealed the presence of enzootic and bridge vectors mosquitoes, including Culiseta (Climacura) melanura (Coquillett), Aedes (Aedimorphus) vexans (Meigen), and Coquillettidia (Coquillettidia) perturbans (Walker). Select mosquito species were tested by RT-PCR for the presence of EEEV. None were positive. This is the first report of EEEV in moose from Maine. C1 [Lubelczyk, Charles; Elias, Susan P.; Smith, Leticia B.; Smith, Robert Pease] Maine Med Ctr, Res Inst, Vector Borne Dis Lab, South Portland, ME USA. [Kantar, Lee] Maine Dept Inland Fisheries & Wildlife, Bangor, ME USA. [Albert, Jennifer; Hansen, Stephen] Univ Maine, Dept Biol, Ft Kent, ME USA. [Saxton-Shaw, Kali; MacMillan, Katharine; Eisen, Rebecca; Swope, Bethany; Mutebi, John-Paul] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Lubelczyk, C (reprint author), Maine Med Ctr, Res Inst, Vector Borne Dis Lab, 81 Res Dr, Scarborough, ME 04074 USA. EM lubelc@mmc.org NR 31 TC 2 Z9 3 U1 1 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2014 VL 14 IS 1 BP 77 EP 81 DI 10.1089/vbz.2012.1172 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 284ZE UT WOS:000329360400011 PM 24359417 ER PT J AU Larson, TC Franzblau, A Lewin, M Goodman, AB Antao, VC AF Larson, Theodore C. Franzblau, Alfred Lewin, Michael Goodman, Alyson B. Antao, Vinicius C. TI Impact of Body Mass Index on the Detection of Radiographic Localized Pleural Thickening SO ACADEMIC RADIOLOGY LA English DT Article DE Radiograph; pneumoconiosis; predictive values ID CHEST RADIOGRAPHS; ASBESTOS; EXPOSURE; OBESITY; WORKERS; VERMICULITE; OVERWEIGHT; DISEASES; ADULTS; LIBBY AB Rationale and Objectives: Subpleural fat can be difficult to distinguish from localized pleural thickening (LPT), a marker of asbestos exposure, on chest radiographs. The aims of this study were to examine the influence of body mass index (BMI) on the-performance of radiograph readers when classifying LPT and to model the risk of false test results with varying BMI. Materials and Methods: Subjects (n = 200) were patients being screened or treated for asbestos-related health outcomes. A film chest radiograph, a digital chest radiograph, and a high-resolution computed tomography (HRCT) chest scan were collected from each subject. All radiographs were independently read by seven B readers and scored using the International Labour Office system. HRCT scans, read by three experienced thoracic radiologists, served as the gold standard for the presence of LPT. We calculated measures of radiograph reader performance, including sensitivity and specificity, for each image modality. We also used logistic regression to estimate the probability of a false-positive and a false-negative result while controlling for covariates. Results: The proportion of false-positive readings correlated with BMI. While controlling for covariates, regression modeling showed the probability of a false-positive result increased with increasing BMI category, younger age, not having pleural calcification, and among subjects not reporting occupational or household contact asbestos exposure. Conclusions: Clinicians should be cautious when-evaluating-radiographs of younger obese persons for the presence of asbestos-related pleural plaque, particularly in populations having an anticipated low or background prevalence of LPT. C1 [Larson, Theodore C.; Lewin, Michael; Antao, Vinicius C.] Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA 30341 USA. [Franzblau, Alfred] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Goodman, Alyson B.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Larson, TC (reprint author), Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, 4770 Buford Highway NE,MS F57, Atlanta, GA 30341 USA. EM TLarson@cdc.gov NR 27 TC 4 Z9 4 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1076-6332 EI 1878-4046 J9 ACAD RADIOL JI Acad. Radiol. PD JAN PY 2014 VL 21 IS 1 BP 3 EP 10 DI 10.1016/j.acra.2013.09.014 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 280HI UT WOS:000329018900002 PM 24331259 ER PT J AU Jhung, MA D'Mello, T Perez, A Aragon, D Bennett, NM Cooper, T Farley, MM Fowler, B Grube, SM Hancock, EB Lynfield, R Morin, C Reingold, A Ryan, P Schaffner, W Sharangpani, R Tengelsen, L Thomas, A Thurston, D Yousey-Hindes, K Zansky, S Finelli, L Chaves, SS AF Jhung, Michael A. D'Mello, Tiffany Perez, Alejandro Aragon, Deborah Bennett, Nancy M. Cooper, Tara Farley, Monica M. Fowler, Brian Grube, Stephen M. Hancock, Emily B. Lynfield, Ruth Morin, Craig Reingold, Arthur Ryan, Patricia Schaffner, William Sharangpani, Ruta Tengelsen, Leslie Thomas, Ann Thurston, Diana Yousey-Hindes, Kimberly Zansky, Shelley Finelli, Lyn Chaves, Sandra S. TI Hospital-onset influenza hospitalizations-United States, 2010-2011 SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Health care associated ID CARE-ASSOCIATED INFECTIONS; NOSOCOMIAL TRANSMISSION; TRANSPLANT RECIPIENTS; VIRUS-INFECTIONS; ADULTS; OUTBREAK; CHILDREN; DURATION; LENGTH AB Background: Seasonal influenza is responsible for more than 200,000 hospitalizations each year in the United States. Although hospital-onset (HO) influenza contributes to morbidity and mortality among these patients, little is known about its overall epidemiology. Objective: We describe patients with HO influenza in the United States during the 2010-2011 influenza season and compare them with community-onset (CO) cases to better understand factors associated with illness. Methods: We identified laboratory-confirmed, influenza-related hospitalizations using the Influenza Hospitalization Surveillance Network (FluSurv-NET), a network that conducts population-based surveillance in 16 states. CO cases had laboratory confirmation <= 3 days after hospital admission; HO cases had laboratory confirmation > 3 days after admission. Results: We identified 172 (2.8%) HO cases among a total of 6,171 influenza-positive hospitalizations. HO and CO cases did not differ by age (P = .22), sex (P = .29), or race (P = .25). Chronic medical conditions were more common in HO cases (89%) compared with CO cases (78%) (P < .01), and a greater proportion of HO cases (42%) than CO cases (17%) were admitted to the intensive care unit (P < .01). The median length of stay after influenza diagnosis of HO cases (7.5 days) was greater than that of CO cases (3 days) (P < .01). Conclusion: HO cases had greater length of stay and were more likely to be admitted to the intensive care unit or die compared with CO cases. HO influenza may play a role in the clinical outcome of hospitalized patients, particularly among those with chronic medical conditions. Published by Elsevier Inc. on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. C1 [Jhung, Michael A.; D'Mello, Tiffany; Perez, Alejandro; Finelli, Lyn; Chaves, Sandra S.] Ctr Dis Control & Prevent, Influenza Div, Epidemiol & Prevent Branch, Atlanta, GA 30333 USA. [Aragon, Deborah] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA. [Cooper, Tara] Rhode Isl Dept Hlth, Providence, RI 02908 USA. [Farley, Monica M.] Emory Univ, Georgia Div Publ Hlth, Georgia Emerging Infect Program, Atlanta, GA 30322 USA. [Fowler, Brian; Zansky, Shelley] Ohio Dept Hlth, Columbus, OH 43266 USA. [Grube, Stephen M.] Oklahoma Dept Hlth, Oklahoma City, OK USA. [Hancock, Emily B.] New Mexico Dept Hlth, Santa Fe, NM USA. [Lynfield, Ruth; Morin, Craig] Minnesota Dept Hlth, St Paul, MN USA. [Reingold, Arthur] Calif Emerging Infect Program, Oakland, CA USA. [Ryan, Patricia] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Sharangpani, Ruta] Michigan Dept Community Hlth, Lansing, MI USA. [Tengelsen, Leslie] Idaho Dept Hlth & Welf, Boise, ID USA. [Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Thurston, Diana] Salt Lake Valley Hlth Dept, Salt Lake City, UT USA. [Yousey-Hindes, Kimberly] Yale Univ, Sch Publ Hlth, Connecticut Emerging Infect Program, New Haven, CT USA. RP Jhung, MA (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM MJhung@cdc.gov OI Yousey-Hindes, Kimberly/0000-0002-9418-575X NR 30 TC 6 Z9 6 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD JAN PY 2014 VL 42 IS 1 BP 7 EP 11 DI 10.1016/j.ajic.2013.06.018 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 282IT UT WOS:000329165200005 PM 24183534 ER PT J AU Zheteyeva, YA Tosh, P Patel, PR Martinez, D Kilborn, C Awosika-Olumo, D Khuwaja, S Ibrahim, S Ryder, A Tohme, RA Khudyakov, Y Thai, H Drobeniuc, J Heseltine, G Guh, AY AF Zheteyeva, Yenlik A. Tosh, Pritish Patel, Priti R. Martinez, Diana Kilborn, Cindy Awosika-Olumo, Debo Khuwaja, Salma Ibrahim, Syed Ryder, Anthony Tohme, Rania A. Khudyakov, Yury Thai, Hong Drobeniuc, Jan Heseltine, Gary Guh, Alice Y. TI Hepatitis B outbreak associated with a home health care agency serving multiple assisted living facilities in Texas, 2008-2010 SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Blood glucose monitoring; Infection control; Patient safety ID TRANSMISSION AB We investigated a multifacility outbreak of acute hepatitis B virus infection involving 21 residents across 10 assisted living facilities in Texas during the period January 2008 through July 2010. Epidemiologic and laboratory data suggested that these infections belonged to a single outbreak. The only common exposure was receipt of assisted monitoring of blood glucose from the same home health care agency. Improved infection control oversight and training of assisted living facility and home health care agency personnel providing assisted monitoring of blood glucose is needed. Published by Elsevier Inc. on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. C1 [Zheteyeva, Yenlik A.; Tosh, Pritish; Patel, Priti R.; Guh, Alice Y.] Ctr Dis Control & Prevent, Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Zheteyeva, Yenlik A.; Tosh, Pritish; Tohme, Rania A.] Ctr Dis Control & Prevent, Sci Educ & Profess Dev Program Off, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Martinez, Diana; Kilborn, Cindy] Harris Cty Publ Hlth & Environm Serv, Houston, TX USA. [Awosika-Olumo, Debo; Khuwaja, Salma] City Houston Dept Hlth & Human Serv, Houston, TX USA. [Ibrahim, Syed] Montgomery Cty Publ Hlth Dept, Conroe, TX USA. [Ryder, Anthony] Ft Bend Cty Hlth & Human Serv, Rosenberg, TX USA. [Tohme, Rania A.; Khudyakov, Yury; Thai, Hong; Drobeniuc, Jan] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Heseltine, Gary] Texas Dept State Hlth Serv, Austin, TX USA. RP Guh, AY (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-31, Atlanta, GA 30333 USA. EM ggt4@cdc.gov NR 10 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD JAN PY 2014 VL 42 IS 1 BP 77 EP 81 DI 10.1016/j.ajic.2013.06.016 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 282IT UT WOS:000329165200021 PM 24176604 ER PT J AU Zhu, JL Obel, C Hasle, H Rasmussen, SA Li, J Olsen, J AF Zhu, Jin Liang Obel, Carsten Hasle, Henrik Rasmussen, Sonja A. Li, Jiong Olsen, Jorn TI Social Conditions for People With Down Syndrome: A Register-Based Cohort Study in Denmark SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE Down syndrome; mosaic trisomy 21; social conditions; offspring ID POPULATION; LIFE; CHILDREN; TRISOMY-21; FERTILITY; SURVIVAL; DISEASE; HEALTH; HOSPITALIZATIONS; MORTALITY AB Today, most persons with Down syndrome (DS) survive into middle age, but information on their social conditions as adults is limited. We addressed this knowledge gap using data from national registers in Denmark. We identified a national cohort of 1,998 persons with DS who were born between 1968 and 2007 (1,852 with standard trisomy 21, 80 with Robertsonian translocations and 66 with mosaicism) using the Danish Cytogenetic Register. We followed this cohort from 1980 to 2007. Information on social conditions (education, employment, source of income, marital status, etc.) was obtained by linkages to national registers, including the Integrated Database for Longitudinal Labor Market Research. For those aged 18 and older, more than 80% of persons with DS attended 10 years of primary school, with about 2% completing secondary or post-secondary education. About 4% obtained a full-time job, whereas the remaining mainly received public support from the government. Only a few (1-2%) of persons with DS were married or had a child. No significant differences in these social conditions were seen between males and females. More persons with mosaic DS attended secondary or post-secondary education, had a full-time job, were married, or had a child (18%, 28%, 15%, and 7%, respectively), compared with persons with standard DS (1%, 2%, 1%, and 1%, respectively). These data may provide families with better insight into social conditions and society with a better understanding of the social support needed for persons with DS. (c) 2013 Wiley Periodicals, Inc. C1 [Zhu, Jin Liang; Obel, Carsten] Aarhus Univ, Dept Publ Hlth, Res Program Childrens Mental Hlth, DK-8000 Aarhus C, Denmark. [Zhu, Jin Liang; Li, Jiong; Olsen, Jorn] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, DK-8000 Aarhus C, Denmark. [Obel, Carsten] Aarhus Univ, Dept Publ Hlth, Sect Gen Practice, DK-8000 Aarhus C, Denmark. [Hasle, Henrik] Aarhus Univ Hosp, Dept Pediat, DK-8000 Aarhus, Denmark. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RP Zhu, JL (reprint author), Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Bartholins Alle 2, DK-8000 Aarhus C, Denmark. EM zjl@soci.au.dk RI li, jiong/L-6534-2014; OI li, jiong/0000-0002-1716-8067; Hasle, Henrik/0000-0003-3976-9231 FU Centers for Disease Control and Prevention (CDC) [5 U10 DD000230-06]; European Research Council [260242]; Tryg Foundation [7-11-1155] FX Grant sponsor: Centers for Disease Control and Prevention (CDC); Grant number: #5 U10 DD000230-06; Grant sponsor: European Research Council; Grant number: 260242; Grant sponsor: Tryg Foundation; Grant number: 7-11-1155. NR 31 TC 3 Z9 3 U1 2 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4825 EI 1552-4833 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD JAN PY 2014 VL 164 IS 1 BP 36 EP 41 DI 10.1002/ajmg.a.36272 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA 276FV UT WOS:000328734900006 PM 24273114 ER PT J AU Jackson, JM Crider, KS Cragan, JD Rasmussen, SA Olney, RS AF Jackson, Jodi M. Crider, Krista S. Cragan, Janet D. Rasmussen, Sonja A. Olney, Richard S. TI Frequency of Prenatal Cytogenetic Diagnosis and Pregnancy Outcomes by Maternal Race-Ethnicity, and the Effect on the Prevalence of Trisomy 21, Metropolitan Atlanta, 1996-2005 SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE trisomy 21; Down syndrome; prenatal; cytogenetics; congenital defect; elective termination ID DOWN-SYNDROME; BIRTH-DEFECTS; UNITED-STATES; AMNIOCENTESIS; POPULATION; CALIFORNIA; WOMEN; ACCEPTANCE; EXPERIENCE AB The prevalence of trisomy 21 has been reported to differ by race-ethnicity, however, the results are inconsistent and the cause of the differences is unknown. Using data from 1996 to 2005 from the Metropolitan Atlanta Congenital Defects Program (MACDP), we analyzed the use of prenatal cytogenetic testing and the subsequent use of elective termination among pregnancies affected with any MACDP-eligible birth defect and trisomy 21, by maternal race-ethnicity. We then examined whether these factors could explain the observed differences in the prevalence of trisomy 21 among race-ethnicity groups. Among all pregnancies with birth defects, prenatal cytogenetic testing as well as elective terminations after an abnormal prenatal cytogenetic test result were observed less frequently among Hispanic women than among non-Hispanic white women (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.56-0.78, respectively). In pregnancies affected by trisomy 21, both the Hispanic and the non-Hispanic black populations had more live births (89.5% and 77.8%, respectively) and fewer elective terminations (5.7% and 15.2%, respectively) compared to the non-Hispanic white population (63.0% live births, 32.3% elective terminations). After adjusting for elective terminations, non-Hispanic white mothers had a higher live birth prevalence of trisomy 21 compared to non-Hispanic black (OR 0.64, 95% CI 0.54-0.76) or Hispanic mothers (OR 0.69, 95% CI 0.55-0.86). Overall, our data suggest that factors associated with decisions made about the use of prenatal testing, and about pregnancy management after testing, might play a large role in the race-ethnicity differences observed in the live birth prevalence of trisomy 21. (c) 2013 Wiley Periodicals, Inc. C1 [Jackson, Jodi M.; Crider, Krista S.; Cragan, Janet D.; Rasmussen, Sonja A.; Olney, Richard S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Jackson, JM (reprint author), 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM hwi4@cdc.gov FU Intramural CDC HHS [CC999999] NR 25 TC 4 Z9 4 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4825 EI 1552-4833 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD JAN PY 2014 VL 164 IS 1 BP 70 EP 76 DI 10.1002/ajmg.a.36247 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 276FV UT WOS:000328734900011 PM 24273106 ER PT J AU Pratt, LA Brody, DJ AF Pratt, Laura A. Brody, Debra J. TI Implications of two-stage depression screening for identifying persons with thoughts of self-harm SO GENERAL HOSPITAL PSYCHIATRY LA English DT Article DE Depression; Self-harm; Screening; PHQ-9; NHANES ID PATIENT HEALTH QUESTIONNAIRE; PRIMARY-CARE PATIENTS; SUICIDAL IDEATION; MAJOR DEPRESSION; CANCER-PATIENTS; OLDER-ADULTS; PHQ-9; ADOLESCENTS; HEART; RISK AB Objective: Persons with thoughts of self-harm may need evaluation for suicide risk. We examine the prevalence of thoughts of self-harm and whether persons with thoughts of self-harm are identified when two-stage depression screening is used. Methods: Data are from the 2005-2010 National Health and Nutrition Examination Surveys. Persons responding positively to question nine of the Patient Health Questionnaire-9 (PHQ-9) are identified as having thoughts of self-harm. We compare two depression cutoff scores for the Patient Health Questionnaire-2 (PHQ-2) to see what percentage of persons with thoughts of self-harm would be identified as needing further screening with the PHQ-9. Results: The prevalence of thoughts of self-harm was 3.5%. Persons 12-17 years old, poor and reporting fair or poor health were more likely to report thoughts of self-harm. A cutoff score of three on the PHQ-2 identified 49% of persons with thoughts of self-harm for further screening with the PHQ-9. A cut point of two increased the proportion of persons with thoughts of self-harm continuing for further screening to 76%. Conclusions: Using a lower cutoff score, two, the PHQ-2 captures more persons with thoughts of self-harm. One quarter of persons with self-harm thoughts may not be identified for further screening when two-stage screening is used. Published by Elsevier Inc. C1 [Pratt, Laura A.] Ctr Dis Control & Prevent, Off Anal & Epidemiol, Natl Ctr Hlth Stat, Atlanta, GA 30329 USA. [Brody, Debra J.] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Natl Ctr Hlth Stat, Atlanta, GA 30329 USA. RP Pratt, LA (reprint author), Natl Ctr Hlth Stat, 3311 Toledo Rd,Rm 6333, Hyattsville, MD 20782 USA. EM lpratt@cdc.gov NR 40 TC 3 Z9 3 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0163-8343 EI 1873-7714 J9 GEN HOSP PSYCHIAT JI Gen. Hosp. Psych. PD JAN-FEB PY 2014 VL 36 IS 1 BP 119 EP 123 DI 10.1016/j.genhosppsych.2013.09.007 PG 5 WC Psychiatry SC Psychiatry GA 281OY UT WOS:000329112100024 PM 24183490 ER PT J AU Simmons, GM Frick, N Wang, A Miller, ME Fragueiro, D AF Simmons, G. M. Frick, N. Wang, A. Miller, M. E. Fragueiro, D. TI Identifying information needs among children and teens living with haemophilia SO HAEMOPHILIA LA English DT Article DE adolescents; children; disclosure; haemophilia; sports; transition AB Transitioning from one life stage to the next can be difficult, but for those living with a chronic condition, it can be even more challenging. Children and adolescents with haemophilia need help to manage transitions while dealing with the complications of their disorder. The National Haemophilia Foundation (NHF), headquartered in New York City, has an extensive information centre on bleeding disorders, but it was not clear how much material existed on the topic of transition. The objectives of this project were to (i) assess the availability of literature about transition for children and adolescents living with haemophilia, (ii) determine which transition issues were the most relevant and (iii) develop and test information products that would address those transition issues. An inventory of NHF's resources and an environmental scan over the Internet was performed. Focus groups were conducted to determine messaging. Video prototypes containing messages were created, tested by focus groups and revised. The literature search yielded limited information available on transition for children and adolescents with haemophilia. Results of the formative research indicated that adolescents wanted more information on sports participation and disclosure of their condition (e.g. to peers, teachers, coaches, health care providers). Video was found to be the preferred delivery format. Children and adolescents living with haemophilia need information to help them transition through life. As a result of this study, two educational products were produced, but several more are recommended to guide these individuals in making healthy transitions into adulthood. C1 [Simmons, G. M.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA 30333 USA. [Frick, N.; Wang, A.] Natl Hemophilia Fdn, New York, NY USA. [Miller, M. E.; Fragueiro, D.] ICF Int, Strateg Commun & Mkt Div, Rockville, MD USA. RP Simmons, GM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, 1600 Clifton Rd,MS E 64, Atlanta, GA 30333 USA. EM gmsimmons@cdc.gov FU CDC FX This project was funded by CDC, under a contract to ICF International, to research relevant information resources, find gaps in primary subject areas and to determine the most appropriate messages to help youth with haemophilia manage their condition as they transition to adulthood. The authors acknowledge the members of the HANDI Evaluation Working Group including: Maggie Gallarno of the University of Mississippi Medical Center; Chasity L. Mullins, R.N., B.S.N., of the Vanderbilt University Medical Center; Jean Marandola, R.N., M.S., from Rhode Island Hospital; Marion Koerper, M.D., of the UCSF Haemophilia Program; Ruth Mulvany, R.P.T. of the University of Tennessee; Regina Butler, R.N., Children's Hospital of Philadelphia; Casey Nakatani of the Haemophilia Foundation of Southern California; Deborah Adamkin of the Florida Haemophilia Association; Rob Alexander of the Central Ohio Chapter of NHF; Ann Henningfield of the Haemophilia Foundation of Michigan; and Brent Movitz of the National Youth Leadership Institute. The authors thank Dawn Rotellini, Michelle Rice and Jennifer Crawford of the National Haemophilia Foundation for their support and guidance through the life of the project. The authors thank Sally McAlister for her early contributions to the conceptualization of this project. The authors also thank the NHF Chapter Staff who assisted with recruitment efforts among parent and adolescent participants and for informing the development and increasing the potential utility of these two videos. NR 13 TC 2 Z9 2 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1351-8216 EI 1365-2516 J9 HAEMOPHILIA JI Haemophilia PD JAN PY 2014 VL 20 IS 1 BP 1 EP 8 DI 10.1111/hae.12223 PG 8 WC Hematology SC Hematology GA 276FG UT WOS:000328733300001 PM 23809876 ER PT J AU Puetz, J Soucie, JM Kempton, CL Monahan, PE AF Puetz, J. Soucie, J. M. Kempton, C. L. Monahan, P. E. CA HTCN Investigators TI Prevalent inhibitors in haemophilia B subjects enrolled in the Universal Data Collection database SO HAEMOPHILIA LA English DT Article DE factor IX; haemophilia B; inhibitors; prevalence; race; Universal Data Collection ID PREVIOUSLY UNTREATED PATIENTS; FACTOR-IX; FACTOR-VIII; EFFICACY; REGISTRY; SAFETY; COHORT; RISK AB Several risk factors for inhibitors have recently been described for haemophilia A. It has been assumed that similar risk factors are also relevant for haemophilia B, but there is limited data to confirm this notion. The aim of this study was to determine the prevalence of and risk factors associated with inhibitors in haemophilia B. The database of the Universal Data Collection (UDC) project of the Centers for Disease Control for the years 1998-2011 was queried to determine the prevalence of inhibitors in haemophilia B subjects. In addition, disease severity, race/ethnicity, age, factor exposure and prophylaxis usage were evaluated to determine their impact on inhibitor prevalence. Of the 3785 male subjects with haemophilia B enrolled in the UDC database, 75 (2%) were determined to have an inhibitor at some point during the study period. Severe disease (OR 13.1, 95% CI 6.2-27.7), black race (OR 2.2, 95% CI 1.2-4.1), and age <11years (OR 2.5, 95% CI 1.5-4.0) were found to be significantly associated with having an inhibitor. There was insufficient data to determine if type of factor used and prophylaxis were associated with inhibitors. Inhibitors in haemophilia B are much less prevalent than haemophilia A, especially in patients with mild disease. Similar factors associated with inhibitors in haemophilia A also seem to be present for haemophilia B. The information collected by this large surveillance project did not permit evaluation of potential risk factors related to treatment approaches and exposures, and additional studies will be required. C1 [Puetz, J.] St Louis Univ, Dept Pediat, Div Hematol Oncol, St Louis, MO 63104 USA. [Soucie, J. M.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Kempton, C. L.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA. [Kempton, C. L.] Emory Univ, Dept Hematol Oncol, Atlanta, GA 30322 USA. [Monahan, P. E.] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA. [Monahan, P. E.] Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA USA. RP Puetz, J (reprint author), St Louis Univ, Dept Pediat, Div Hematol Oncol, 1465 S Grand, St Louis, MO 63104 USA. EM puetzjj@slu.edu RI Kerlin, Bryce/E-3369-2011 OI Kerlin, Bryce/0000-0002-1756-8271 FU Prevention of Bleeding Disorder Complications through Regional Hemophilia Treatment Centers FX The authors acknowledge the assistance of the Universal Data Collection Working Group and the Centers for Disease Control for their help in designing and completing this study, and for the use of the UDC data. The collection and analysis of the data were supported by the Grant/Cooperative Agreement 'Prevention of Bleeding Disorder Complications through Regional Hemophilia Treatment Centers'. We also thank the patients, staff members and physicians of the Hemophilia Treatment Centers who contributed to the UDC database, and especially those who responded to our queries regarding the data. NR 19 TC 16 Z9 17 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1351-8216 EI 1365-2516 J9 HAEMOPHILIA JI Haemophilia PD JAN PY 2014 VL 20 IS 1 BP 25 EP 31 DI 10.1111/hae.12229 PG 7 WC Hematology SC Hematology GA 276FG UT WOS:000328733300008 PM 23855900 ER PT J AU Frieden, TR King, SMC Wright, JS AF Frieden, Thomas R. King, Sallyann M. Coleman Wright, Janet S. TI Protocol-Based Treatment of Hypertension A Critical Step on the Pathway to Progress SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID BLOOD-PRESSURE; AWARENESS; TRENDS C1 [Frieden, Thomas R.; King, Sallyann M. Coleman; Wright, Janet S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS D-14, Atlanta, GA 30333 USA. EM tfrieden@cdc.gov NR 7 TC 18 Z9 18 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 1 PY 2014 VL 311 IS 1 BP 21 EP 22 DI 10.1001/jama.2013.282615 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 282HN UT WOS:000329161400010 PM 24231925 ER PT J AU King, BA Tynan, MA Dube, SR Arrazola, R AF King, Brian A. Tynan, Michael A. Dube, Shanta R. Arrazola, Rene TI Flavored-Little-Cigar and Flavored-Cigarette Use Among US Middle and High School Students SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article ID UNITED-STATES; TOBACCO; CONSUMPTION; BEHAVIOR; SMOKING; BRANDS; ADULTS; YOUTH AB Purpose: Flavors can mask the harshness and taste of tobacco, making flavored tobacco products appealing to youth. We assessed the prevalence and correlates of flavored-little-cigar and flavored-cigarette use among U.S. middle and high school students in 2011. Methods: Data were obtained from the 2011 National Youth Tobacco Survey, a nationally representative school-based survey of U.S. students in grades 6-12. National estimates of current flavored-little-cigar use, flavored-cigarette use, and combined use of either product were calculated overall and among current smokers by respondent characteristics, including sex, race/ethnicity, school level, and grade. Additionally, intention to quit tobacco and smoking frequency were assessed by flavored product use. Results: The overall prevalence of current use was 4.2% for flavored cigarettes, 3.3% for flavored little cigars, and 6.3% for either product. Among current cigar smokers, 35.9% reported using flavored little cigars, and among current cigarette smokers, 35.4% reported using flavored cigarettes. Among current cigar or cigarette smokers, 42.4% reported using flavored little cigars or flavored cigarettes. Flavored product use among current smokers was higher among non-Hispanic whites than among blacks and Hispanics, higher among high school students than middle school students, and increased with grade. Among cigar smokers, prevalence of no intention to quit tobacco was higher among flavored-little-cigar users (59.7%) than nonusers (49.3%). Conclusions: More than two fifths of U.S. middle and high school smokers report using flavored little cigars or flavored cigarettes, and disparities in the use of these products exist across subpopulations. Efforts are needed to reduce flavored tobacco product use among youth. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [King, Brian A.; Tynan, Michael A.; Dube, Shanta R.; Arrazola, Rene] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30341 USA. RP King, BA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, 4770 Buford Highway,MS F-79, Atlanta, GA 30341 USA. EM baking@cdc.gov FU Intramural CDC HHS [CC999999] NR 33 TC 40 Z9 40 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2014 VL 54 IS 1 BP 40 EP 46 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 280WV UT WOS:000329062400007 PM 24161587 ER PT J AU Arrazola, RA Kuiper, NM Dube, SR AF Arrazola, Rene A. Kuiper, Nicole M. Dube, Shanta R. TI Patterns of Current Use of Tobacco Products Among US High School Students for 2000-2012-Findings From the National Youth Tobacco Survey SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article ID CIGARETTE SMOKERS; UNITED-STATES; ADOLESCENTS; DEPENDENCE AB Purpose: The purpose of this study was to assess patterns and trends of tobacco use among high school students to better understand which products are used individually or concurrently. Methods: Data from the National Youth Tobacco Survey from 2000 through 2012 were used to assess patterns and trends of current tobacco use (cigarettes, cigars, smokeless tobacco, and other tobacco products) among U. S. high school students. We assessed use of products individually and concurrently. Results: During 2000-2012, overall linear declines were observed in current use of any tobacco product from 33.6% to 20.4% (p < .05), current use of only 1 tobacco product, from 18.8% to 10.5% (p < .05), and current poly tobacco use, from 14.7% to 9.9% (p < .05), among high school students. Overall current use of only cigarettes had both a linear decline, from 14.0% to 4.7%, as well as a quadratic trend. Conclusions: During 2000-2012, the most significant overall decline observed was for students who reported smoking only cigarettes. The results suggest that more data on the use of multiple tobacco products, not just cigarettes, is needed to guide tobacco prevention and control policies and programs. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Arrazola, Rene A.; Kuiper, Nicole M.; Dube, Shanta R.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30341 USA. RP Arrazola, RA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, 4770 Buford Highway NE,MS F-79, Atlanta, GA 30341 USA. EM RArrazola@cdc.gov FU Intramural CDC HHS [CC999999] NR 20 TC 29 Z9 29 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2014 VL 54 IS 1 BP 54 EP U173 DI 10.1016/j.jadohealth.2013.08.003 PG 16 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 280WV UT WOS:000329062400009 PM 24074604 ER PT J AU Lowry, R Crosby, AE Brener, ND Kann, L AF Lowry, Richard Crosby, Alexander E. Brener, Nancy D. Kann, Laura TI Suicidal Thoughts and Attempts Among US High School Students: Trends and Associated Health-Risk Behaviors, 1991-2011 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article ID ADOLESCENT SUICIDE; UNITED-STATES; SUBSTANCE USE; PRIMARY-CARE; IDEATION; PREVENTION AB Purpose: To describe secular trends in suicidal thoughts and attempts and the types of health-risk behaviors associated with suicidal thoughts and attempts among U. S. high school students. Methods: Data were analyzed from 11 national Youth Risk Behavior Surveys conducted biennially during 1991-2011. Each survey employed a nationally representative sample of students in grades 9-12 and provided data from approximately 14,000 students. Using sex-stratified logistic regression models that controlled for race/ethnicity and grade, we analyzed secular trends in the prevalence of suicidal thoughts and attempts. Adjusted prevalence ratios (APR) were calculated to measure associations between suicide risk and a broad range of health-risk behaviors. Results: During 1991-2011, among female students, both suicidal thoughts (seriously considered suicide; made a plan to attempt suicide) and attempts (any attempt; attempt with injury requiring medical treatment) decreased significantly; among male students, only suicidal thoughts decreased significantly. During 2011, compared with students with no suicidal thoughts or attempts, the health-risk behaviors most strongly associated with suicide attempts among female students were injection drug use (APR=12.8), carrying a weapon on school property (APR=9.7), and methamphetamine use (APR=8.7); among male students, the strongest associations were for IDU (APR=22.4), using vomiting/laxatives for weight control (APR=17.1), and having been forced to have sex (APR=14.8). Conclusions: School-based suicide prevention programs should consider confidential screening for health-risk behaviors that are strongly associated with suicide attempts to help identify students at increased risk for suicide and provide referrals to suicide and other prevention services (e. g., substance abuse and violence prevention) as appropriate. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Lowry, Richard; Brener, Nancy D.; Kann, Laura] Natl Ctr HIV AIDS, Div Adolescent & Sch Hlth, Atlanta, GA USA. [Crosby, Alexander E.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA 30341 USA. RP Lowry, R (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, 4770 Buford Hwy NE Mailstop K-33, Atlanta, GA 30341 USA. EM rxl1@cdc.gov NR 39 TC 7 Z9 7 U1 4 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2014 VL 54 IS 1 BP 100 EP 108 DI 10.1016/j.jadohealth.2013.07.024 PG 9 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 280WV UT WOS:000329062400016 PM 24035267 ER PT J AU Kossover, RA Chi, CJ Wise, ME Tran, AH Chande, ND Perz, JF AF Kossover, Rachel A. Chi, Carolyn J. Wise, Matthew E. Tran, Alvin H. Chande, Neha D. Perz, Joseph F. TI Infection Prevention and Control Standards in Assisted Living Facilities: Are Residents' Needs Being Met? SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION LA English DT Article DE Assisted living; health policy; health care-associated infection; infection prevention; health care workers ID BLOOD-GLUCOSE; CENTRAL MARYLAND; HEALTH-CARE; TRANSMISSION; OUTBREAKS; VIRGINIA; ILLNESS AB Background: Assisted living facilities (ALFs) provide housing and care to persons unable to live independently, and who often have increasing medical needs. Disease outbreaks illustrate challenges of maintaining adequate resident protections in these facilities. Objectives: Describe current state laws on assisted living admissions criteria, medical oversight, medication administration, vaccination requirements, and standards for infection control training. Methods: We abstracted laws and regulations governing assisted living facilities for the 50 states using a structured abstraction tool. Selected characteristics were compared according to the time period in which the regulation took effect. Selected state health departments were queried regarding outbreaks identified in assisted living facilities. Results: Of the 50 states, 84% specify health-based admissions criteria to assisted living facilities; 60% require licensed health care professionals to oversee medical care; 88% specifically allow subcontracting with outside entities to provide routine medical services onsite; 64% address medication administration by assisted living facility staff; 54% specify requirements for some form of initial infection control training for all staff; 50% require reporting of disease outbreaks to the health department; 18% specify requirements to offer or require vaccines to staff; 30% specify requirements to offer or require vaccines to residents. Twelve states identified approximately 1600 outbreaks from 2010 to 2013, with influenza or norovirus infections predominating. Conclusions: There is wide variation in how assisted living facilities are regulated in the United States. States may wish to consider regulatory changes that ensure safe health care delivery, and minimize risks of infections, outbreaks of disease, and other forms of harm among assisted living residents. Published by Elsevier Inc. on behalf of American Medical Directors Association, Inc. C1 [Kossover, Rachel A.; Chi, Carolyn J.; Wise, Matthew E.; Tran, Alvin H.; Chande, Neha D.; Perz, Joseph F.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Kossover, RA (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A-31, Atlanta, GA 30333 USA. EM gvb7@cdc.gov FU Intramural CDC HHS [CC999999] NR 39 TC 3 Z9 3 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-8610 EI 1538-9375 J9 J AM MED DIR ASSOC JI J. Am. Med. Dir. Assoc. PD JAN PY 2014 VL 15 IS 1 BP 47 EP 53 DI 10.1016/j.jamda.2013.09.011 PG 7 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 280WE UT WOS:000329060700008 PM 24239014 ER PT J AU Shcherbik, S Sergent, SB Davis, WG Shu, B Barnes, J Kiseleva, I Larionova, N Klimov, A Bousse, T AF Shcherbik, Svetlana Sergent, Sheila B. Davis, William G. Shu, Bo Barnes, John Kiseleva, Irina Larionova, Natalie Klimov, Alexander Bousse, Tatiana TI Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Influenza virus; Reassortants; Live vaccine; Real time RT-PCR; Homogeneity test ID VIRUS VACCINE; RESTRICTION ANALYSIS; GENOME COMPOSITION; ASSAY; VALIDATION; EFFICACY; STRAINS; H1N1; RNA; H7 AB Development and improvement of quality control tests for live attenuated vaccines are a high priority because of safety concerns. Live attenuated influenza vaccine (LAIV) viruses are 6:2 reassortants containing the hemagglutinin (HA) and neuraminidase (NA) gene segments from circulating influenza viruses to induce protective immune responses, and the six internal gene segments from a cold-adapted Master Donor Virus (MDV). LAIV candidate viruses for the 2012-2013 seasons, A/Victoria/361/2011-CDC-LV1 (LV1) and B/Texas/06/2011-CDC-LV2B (LV2B), were created by classical reassortment of A/Victoria/361/2011 and MDV-A A/Leningrad/134/17/57 (H2N2) or B/Texas/06/2011 and MDV-B B/USSR/60/69. In an attempt to provide better identity and stability testing for quality control of LV1 and LV2B, sensitive real-time RT-PCR assays (rRT-PCR) were developed to detect the presence of undesired gene segments (HA and NA from MDV and the six internal genes from the seasonal influenza viruses). The sensitivity of rRT-PCR assays designed for each gene segment ranged from 0.08 to 0.8EID50 (50% of Egg Infectious Dose) per reaction for the detection of undesired genes in LV1 and from 0.1 to 1 EID50 per reaction for the detection of undesired genes in LV2B. No undesired genes were detected either before or after five passages of LV1 or LV2B in eggs. The complete genome sequencing of LV1 and LV2B confirmed the results of rRT-PCR, demonstrating the utility of the new rRT-PCR assays to provide the evidence for the homogeneity of the prepared vaccine candidate. Published by Elsevier B.V. C1 [Shcherbik, Svetlana; Sergent, Sheila B.; Davis, William G.; Shu, Bo; Barnes, John; Klimov, Alexander; Bousse, Tatiana] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Shcherbik, Svetlana; Sergent, Sheila B.; Davis, William G.] Battelle Mem Inst, Atlanta, GA 30329 USA. [Kiseleva, Irina; Larionova, Natalie] Russian Acad Med Sci, Inst Expt Med, Dept Virol, St Petersburg, Russia. RP Bousse, T (reprint author), Ctr Dis Control & Prevent, Virol Surveillance & Diag Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM tbousse@cdc.gov RI Kiseleva, Irina/E-6555-2014; OI Kiseleva, Irina/0000-0002-3892-9873; Larionova, Natalie/0000-0003-1171-3383 FU CDC FX We thank Larisa Rudenko (IEM, St Petersburg, Russia) for providing MDVs, serum to MDVs and protocols for generation and characterization of reassortants. We thank Xiyan Xu for providing wt viruses, Amanda Balish for technical assistance on the project, Jan Mabry for help in preparation of serum to reassortant virus, Angie Foust for help in lyophilization of reassortant, Stephen Lindstrom for providing primers/probe sets for universal detection of H3 and H2 subtypes and detection of PB1 gene of LAIV-A virus (FluMist). We also thank Nancy Cox and Julie Villanueva for the support of project development at CDC. The work described in this report was supported by the World Health Organization (WHO) and the U.S. Department of Health and Human Services Biomedical Advanced Research and Development Authority (HHS BARDA). NR 39 TC 5 Z9 5 U1 0 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD JAN PY 2014 VL 195 BP 18 EP 25 DI 10.1016/j.jviromet.2013.09.003 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 277FQ UT WOS:000328804800003 PM 24056261 ER PT J AU Worwa, G Andrade, CC Thiemann, TC Park, B Maharaj, PD Anishchenko, M Brault, AC Reisen, WK AF Worwa, Gabriella Andrade, Christy C. Thiemann, Tara C. Park, Bborie Maharaj, Payal D. Anishchenko, Michael Brault, Aaron C. Reisen, William K. TI Allele-specific qRT-PCR demonstrates superior detection of single nucleotide polymorphisms as genetic markers for West Nile virus compared to Luminex (R) and quantitative sequencing SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE West Nile virus; Genetic marker; Luminex (R) technology; Quantitative sequencing; qRT-PCR; Fitness competition ID VIRULENCE; EVOLUTION; REPLICATION; MUTATIONS; MOSQUITOS; ARBOVIRUS; ISOLATE; CELLS AB To enable in vivo and in vitro competitive fitness comparisons among West Nile viruses (WNV), three reference viruses were marked genetically by site-directed mutagenesis with five synonymous nucleotide substitutions in the envelope gene region of the genome. Phenotypic neutrality of the mutants was assessed experimentally by competitive replication in cell culture and genetic stability of the substituted nucleotides was confirmed by direct sequencing. Luminex (R) technology, quantitative sequencing and quantitative RT-PCR (qRT-PCR) were compared in regard to specificity, sensitivity and accuracy for quantitation of wildtype and genetically marked viruses in mixed samples based on RNA obtained from samples of known viral titers. Although Luminex (R) technology and quantitative sequencing provided semi-quantitative or qualitative measurements, a sequence-specific primer extension approach using a specific reverse primer set in singleplex qRT-PCR demonstrated the best quantitation and specificity in the detection of RNA from wildtype and mutant viruses. (C) 2013 Elsevier B.V. All rights reserved. C1 [Worwa, Gabriella; Andrade, Christy C.; Thiemann, Tara C.; Park, Bborie; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Ctr Vectorborne Dis, Davis, CA 95616 USA. [Maharaj, Payal D.; Anishchenko, Michael; Brault, Aaron C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Reisen, WK (reprint author), Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Ctr Vectorborne Dis, Davis, CA 95616 USA. EM wkreisen@ucdavis.edu OI Maharaj, Payal/0000-0002-4157-4479 FU Swiss National Science Foundation (SNSF) [PBBEP3_128345]; Swiss Foundation for Grants in Biology and Medicine (SFGBM) [PASMP3_137034/1]; National Institutes of Health (NIH) [T32 AI074550]; Pacific Southwest Regional Center for Excellence (PSWRCE) [U54 AI065359]; Biomedical Advanced Research and Development Authority (BARDA); National Institutes of Allergy and Infectious Diseases (NIH) [RO1-AI55607] FX The authors acknowledge Dr. Brent Ewing for providing an academic license of PolySNP and PHRED. Special thanks to Dr. Gregory Ebel and Dr. Gerod Hall for their advice on the implementation of the quantitative sequencing. G. Worwa was supported by the Swiss National Science Foundation (SNSF; PBBEP3_128345) and the Swiss Foundation for Grants in Biology and Medicine (SFGBM; PASMP3_137034/1). C. Andrade was supported by the National Institutes of Health training grant (NIH; T32 AI074550). Funding for these studies was provided by the Pacific Southwest Regional Center for Excellence (PSWRCE; U54 AI065359), Biomedical Advanced Research and Development Authority (BARDA), and the National Institutes of Allergy and Infectious Diseases (NIH; RO1-AI55607). NR 18 TC 3 Z9 3 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD JAN PY 2014 VL 195 BP 76 EP 85 DI 10.1016/j.jviromet.2013.09.014 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 277FQ UT WOS:000328804800010 PM 24121135 ER PT J AU Welch, RJ Chang, GJJ Litwin, CM AF Welch, Ryan J. Chang, Gwong-Jen J. Litwin, Christine M. TI Comparison of a commercial dengue IgM capture ELISA with dengue antigen focus reduction microneutralization test and the centers for disease control dengue IgM capture-ELISA SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Dengue; Arbovirus; Microneutralization; ELISA; Antibodies; Flavivirus ID LINKED IMMUNOSORBENT ASSAYS; IMMUNOGLOBULIN-M; INFECTION; DIAGNOSIS; FEVER AB Dengue (DENV) infection is caused by an arbovirus that is a member of the family Flaviviridae, genus Flavivirus. The diagnosis of acute dengue infection using clinical signs and symptoms can be difficult since the manifestations cannot be readily differentiated from other infections. Therefore the diagnosis of acute dengue infection depends upon laboratory assays. Dengue virus ELISAs have been designed for the detection of IgM and IgG antibodies in addition to nonstructural 1 (NS1) antigens. The InBios IgM Dengue ELISA was compared to the Antigen Focus Reduction Microneutralization Test (FR mu NT90) and Centers for Disease Control Dengue IgM Capture-ELISA (CDC MAC-ELISA). The calculated sensitivity, specificity and agreement of the InBios ELISA compared to FR mu NT90 and CDC MAC-ELISA was 88.7% (C.I. 81.4-93.7), 93.1% (C.I. 89.1-95.8) and 91.5% (C.I. 86.3-95.0), respectively. In summary the InBios IgM Dengue ELISA sensitivity and specificity is comparable to other commercially available IgM Capture-ELISAs. (C) 2013 Elsevier B.V. All rights reserved. C1 [Welch, Ryan J.; Litwin, Christine M.] Univ Utah, ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA. [Chang, Gwong-Jen J.] US Dept Hlth & Human Serv, Publ Hlth Serv, Ctr Dis Control & Prevent, Arbovira1 Dis Branch,Div Vector Borne Dis, Ft Collins, CO USA. [Litwin, Christine M.] Univ Utah, Dept Pathol, Salt Lake City, UT USA. RP Litwin, CM (reprint author), Georgia Regents Univ, Med Coll Georgia, Dept Pathol, 1120 15th St, Augusta, GA 30912 USA. EM clitwin@gru.edu FU University of Utah, ARUP Institute for Clinical and Experimental Pathology(R) FX This study was supported by the University of Utah, ARUP Institute for Clinical and Experimental Pathology (R). NR 9 TC 6 Z9 6 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD JAN PY 2014 VL 195 BP 247 EP 249 DI 10.1016/j.jviromet.2013.10.019 PG 3 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 277FQ UT WOS:000328804800035 PM 24161816 ER PT J AU Culzoni, MJ Dwivedi, P Green, MD Newton, PN Fernandez, FM AF Culzoni, Maria J. Dwivedi, Prabha Green, Michael D. Newton, Paul N. Fernandez, Facundo M. TI Ambient mass spectrometry technologies for the detection of falsified drugs SO MEDCHEMCOMM LA English DT Review ID DESORPTION ELECTROSPRAY-IONIZATION; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; COUNTERFEIT ANTIMALARIAL TABLETS; INDUCED CHEMICAL-IONIZATION; REAL-TIME; SURFACE SAMPLING/IONIZATION; SUBSTANDARD MEDICINES; LIQUID-CHROMATOGRAPHY; SOLID-SURFACES; ION-SOURCE AB Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality. Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity. C1 [Culzoni, Maria J.; Dwivedi, Prabha; Fernandez, Facundo M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Culzoni, Maria J.] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Catedra Quim Analit 1, Lab Desarrollo Analit & Quimiometria LADAQ, Santa Fe, Argentina. [Culzoni, Maria J.] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina. [Green, Michael D.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA USA. [Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Oxford Wellcome Trust Res Unit, Lao Oxford Mahosot Hospital Oxford, Viangchan, Lao PDR, Laos. [Newton, Paul N.] Univ Oxford, Churchill Hosp, Ctr Trop Med, Nuffield Dept Med, Oxford, England. [Newton, Paul N.] Univ Oxford, Churchill Hosp, WorldWide Antimalarial Resistance Network, Oxford, England. RP Fernandez, FM (reprint author), Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. EM facundo.fernandez@chemistry.gatech.edu FU Bill and Melinda Gates Foundation to the London School of Hygiene and Tropical Medicine FX The authors are grateful to the ACT consortium for funding their project to assess the quality of drugs in Africa via an award from the Bill and Melinda Gates Foundation to the London School of Hygiene and Tropical Medicine. NR 87 TC 12 Z9 12 U1 3 U2 45 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-2503 EI 2040-2511 J9 MEDCHEMCOMM JI MedChemComm PY 2014 VL 5 IS 1 BP 9 EP 19 DI 10.1039/c3md00235g PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 278JH UT WOS:000328886000001 ER PT J AU Schauer, GL Malarcher, AM Berg, CJ AF Schauer, Gillian L. Malarcher, Ann M. Berg, Carla J. TI Differences in Smoking and Cessation Characteristics Among Adult Nondaily Smokers in the United States: Findings From the 20092010 National Adult Tobacco Survey SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID INTERMITTENT SMOKING; CIGARETTE-SMOKING; HEALTH; LIGHT; PATTERNS AB Nondaily smoking in the United States is increasing. Although differences in smoking and cessation behaviors between daily and nondaily smokers have been documented, differences among nondaily smokers are poorly understood. This study provides updated national data on smoking and cessation characteristics among nondaily versus daily smokers and between subgroups of nondaily smokers. Data were obtained from the 20092010 National Adult Tobacco Survey, a stratified, dual-frame telephone survey conducted in the United States. Participants were categorized into daily smokers, never-daily nondaily smokers (NDNS), recently converted (1 year) nondaily smokers (RCNS), and established-converted (> 1 year) nondaily smokers (ECNS). Chi-square tests were used to assess differences across groups, and multivariable logistic regression was used to identify factors associated with past-year quit attempts. Among nondaily smokers (17.8% of the total sample), 27.1% were NDNS, 37.4% were RCNS, and 35.4% were ECNS. RCNS were the most likely to report ever having tried to quit (p < .0001), having tried to quit in the past year (p < .0001), having used cessation treatment during their last quit attempt (p < .05), and wanting to quit smoking for good (p < .001). Compared with NDNS, RCNS had more than twice the odds of trying to quit in the past year after adjusting for demographics and smoking characteristics (adjusted odds ratio 2.1, 95% confidence interval 1.33.2). No significant differences existed between NDNS and ECNS. RCNS are potentially more interested in quitting and should be specifically targeted with cessation interventions to avoid relapse to daily or long-term nondaily smoking. C1 [Schauer, Gillian L.; Malarcher, Ann M.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Schauer, Gillian L.; Berg, Carla J.] Emory Univ, Atlanta, GA 30322 USA. RP Schauer, GL (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, 4770 Buford Highway NE,Mailstop MS F-79, Atlanta, GA 30341 USA. EM vyc9@cdc.gov NR 28 TC 8 Z9 8 U1 0 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 IS 1 BP 58 EP 68 DI 10.1093/ntr/ntt113 PG 11 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 280VT UT WOS:000329059600008 PM 23925825 ER PT J AU Chaloupka, FJ Kostova, D Shang, C AF Chaloupka, Frank J. Kostova, Deliana Shang, Ce TI Cigarette Excise Tax Structure and Cigarette Prices: Evidence From the Global Adult Tobacco Survey and the US National Adult Tobacco Survey SO NICOTINE & TOBACCO RESEARCH LA English DT Article AB Introduction: The importance of tobacco tax structure in determining the relative prices of different tobacco products and brands has become increasingly recognized. The structuring of tobacco tax across products and brands within a country can impact the variability of prices within a country, shaping consumption and influencing tobacco users' incentives to switch down to cheaper alternatives in response to tax and price increases. Methods: Brand-specific data on the average prices paid for the top 5 cigarette brands in 13 countries were obtained from the Global Adult Tobacco Survey, and for the United States, data were obtained from the National Adult Tobacco Survey. The variability of cigarette prices paid across brands was analyzed in the context of each country's tobacco tax structure. Results: Countries with simpler cigarette tax structures, particularly those that emphasize specific taxes and do not involve tier-based taxes, exhibit less variability in the prices smokers pay for cigarettes across brands. Conclusions: Increases in cigarette taxes in countries with simpler tax structures will be more effective in reducing cigarette smoking and its health and economic consequences than comparable tax increases in countries where tax structures are more complicated and there are greater opportunities for switching to cheaper brands in order to avoid a tax increase. C1 [Chaloupka, Frank J.] Univ Illinois, Dept Econ, Chicago, IL 60608 USA. [Chaloupka, Frank J.; Shang, Ce] Univ Illinois, Inst Hlth Res & Policy, Chicago, IL 60608 USA. [Kostova, Deliana] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Chaloupka, FJ (reprint author), Univ Illinois, Inst Hlth Res & Policy, 1747 W Roosevelt,Room 558, Chicago, IL 60608 USA. EM fjc@uic.edu RI Shang, Ce/L-3617-2016 FU Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies; Bill and Melinda Gates Foundation FX Funding for the Global Adult Tobacco Survey (GATS) is provided by the Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies. Governments of Brazil and India contributed to GATS implementation in their respective countries. The Bill and Melinda Gates Foundation provided additional funding for GATS implementation in China and for analysis. NR 24 TC 9 Z9 10 U1 1 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 SU 1 BP S3 EP S9 DI 10.1093/ntr/ntt121 PG 7 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 282HP UT WOS:000329161700002 PM 23935181 ER PT J AU Kostova, D Chaloupka, FJ Yurekli, A Bettcher, D Prasad, N Asma, S AF Kostova, Deliana Chaloupka, Frank J. Yurekli, Ayda Bettcher, Douglas Prasad, Neena Asma, Samira TI Nicotine and Tobacco Research Special Supplement: Economic Aspects of Tobacco Use in Low- and Middle-Income Countries SO NICOTINE & TOBACCO RESEARCH LA English DT Editorial Material C1 [Kostova, Deliana; Asma, Samira] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Chaloupka, Frank J.] Univ Illinois, Inst Hlth Res & Policy, Dept Econ & Hlth Policy, Chicago, IL USA. [Yurekli, Ayda; Bettcher, Douglas] WHO, CH-1211 Geneva, Switzerland. [Prasad, Neena] Bloomberg Initiat Reduce Tobacco Use, New York, NY USA. RP Kostova, D (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway, Atlanta, GA 30341 USA. EM kiv0@cdc.gov NR 5 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 SU 1 BP S1 EP S2 DI 10.1093/ntr/ntt089 PG 2 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 282HP UT WOS:000329161700001 PM 24343954 ER PT J AU Kostova, D Tesche, J Perucic, AM Yurekli, A Asma, S AF Kostova, Deliana Tesche, Jean Perucic, Anne-Marie Yurekli, Ayda Asma, Samira CA GATS Collaborative Grp TI Exploring the Relationship Between Cigarette Prices and Smoking Among Adults: A Cross-Country Study of Low- and Middle-Income Nations SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID TOBACCO USE AB Evidence on the relationship between cigarette prices and adult smoking in low- and middle-income countries (LMICs) is relatively limited. This study offers new descriptive evidence on this relationship using data from a set of 13 LMICs. We use Global Adult Tobacco Survey (GATS) cross-country data from approximately 200,000 participants aged 15 and older. Estimates on the relationship between prices and adult smoking were obtained from logit models of smoking participation and ordinary least squares models of conditional cigarette demand. Higher prices were associated with lower demand across countries, in terms of both smoking prevalence and daily number of cigarettes smoked among smokers. Our estimates suggest that the total price elasticity of cigarette demand in LMICs is approximately 0.53. We find that higher socioeconomic status (SES), represented through wealth and education effects is associated with lower chance of smoking overall, but among existing smokers, it may be associated with a larger number of cigarettes smoked. After controlling for a set of individual demographic and country characteristics, cigarette prices retain a significant role in shaping cigarette demand across LMICs. Because higher SES is associated with a reduced chance of smoking overall but also with increased daily consumption among current smokers, optimal tobacco tax policies in LMICs may face an added need to accommodate to shifting SES structures within the populations of these countries. C1 [Kostova, Deliana; Tesche, Jean; Asma, Samira] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Tesche, Jean] World Bank, Washington, DC 20433 USA. [Perucic, Anne-Marie; Yurekli, Ayda] WHO, CH-1211 Geneva, Switzerland. RP Kostova, D (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway, Atlanta, GA 30341 USA. EM kiv0@cdc.gov FU Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies; Bill and Melinda Gates Foundation FX Funding for the Global Adult Tobacco Survey (GATS) is provided by the Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies. Governments of Brazil and India contributed to GATS implementation in their respective countries. Bill and Melinda Gates Foundation provided additional funding for GATS implementation in China. NR 27 TC 7 Z9 7 U1 0 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 SU 1 BP S10 EP S15 DI 10.1093/ntr/ntt170 PG 6 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 282HP UT WOS:000329161700003 PM 24343955 ER PT J AU Ross, H Kostova, D Stoklosa, M Leon, M AF Ross, Hana Kostova, Deliana Stoklosa, Michal Leon, Maria TI The Impact of Cigarette Excise Taxes on Smoking Cessation Rates From 1994 to 2010 in Poland, Russia, and Ukraine SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID SOVIET-UNION; TOBACCO; INCREASES; DURATION; BEHAVIOR; PRICES; POLICY; QUIT AB We studied the impact of cigarette excise taxes on the rates of smoking cessation with data from 3 neighboring Eastern European countries (Russia, Poland, and Ukraine) during the post-transitional period of the 1990s and 2000s. Using Global Adult Tobacco Survey data from 11,106 former and current smokers, we estimated the impact of cigarette taxes on the smokers likelihood of quitting over time. We first transformed the surveys cross-sectional data into a pseudo-longitudinal format in which the average observation period for individual subjects was 12 years and then employed duration analysis. We estimated that a 10% increase in cigarette taxes during the observation period increased the probability of smoking cessation among smokers in these countries by 1.6% to 2.3%. Cigarette tax increases have played a significant role in driving smoking cessation in Poland, Russia, and Ukraine. Further increases in cigarette excise taxes are likely to encourage further cessation and thus impact the prevalence of smoking in the region. C1 [Ross, Hana; Stoklosa, Michal] Amer Canc Soc, Atlanta, GA 30303 USA. [Kostova, Deliana] Ctr Dis Control & Prevent, Atlanta, GA USA. [Leon, Maria] Int Agcy Res Canc, F-69372 Lyon, France. RP Ross, H (reprint author), Amer Canc Soc, 250 Williams St, Atlanta, GA 30303 USA. EM hana.ross@cancer.org FU European Commission (EC FP7) under the project Pricing Policies and Control of Tobacco in Europe (PPACTE) [HEALTH-F2-2009-223323]; Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies FX This work was supported by the European Commission (EC FP7) under the project Pricing Policies and Control of Tobacco in Europe (PPACTE) (HEALTH-F2-2009-223323). Funding for the Global Adult Tobacco Survey (GATS) is provided by the Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies. NR 35 TC 4 Z9 5 U1 1 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 SU 1 BP S37 EP S43 DI 10.1093/ntr/ntt024 PG 7 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 282HP UT WOS:000329161700007 PM 24343956 ER PT J AU Shang, C Chaloupka, FJ Kostova, D AF Shang, Ce Chaloupka, Frank J. Kostova, Deliana TI Who Quits? An Overview of Quitters in Low- and Middle-Income Countries SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID SMOKING-CESSATION; CIGARETTE AFFORDABILITY; UNITED-STATES; YOUNG-ADULTS; SMOKERS; INTENTION; YOUTH AB Using the Global Adult Tobacco Surveys from 14 primarily low- and middle-income countries, we describe the association between the probability of being a recent quitter and a number of demographic and policy-relevant factors such as exposure to warning labels, work-site smoking bans, antismoking media messaging, tobacco marketing, and current cigarette and bidi prices. Logistic regressions were used to examine the potential correlates of recent quitting and recent quit attempts. After accounting for country-specific attributes in pooled analyses, we found that higher rates of exposure to work-site smoking bans are associated with higher odds of being a quitter (odds ratio [OR] with 95% confidence interval [CI] 1.13 [1.04, 1.22]). Exposure to antismoking media messaging (OR with 95% CI 1.08 [1.00, 1.17]), work-site smoking bans (OR with 95% CI 1.11 [0.99, 1.26]), and warning labels (OR with 95% CI 1.03 [1.01, 1.05]); cigarette prices (OR with 95% CI 1.01 [1.00, 1.02]), and bidi prices (OR with 95% CI 1.17 [1.11, 1.22]) are factors associated with higher odds of recent quit attempts in the pooled analysis. These effects vary by country. Exposure to warning labels is found to be associated with greater likelihood of recent quitting in Egypt (OR with 95% CI 3.20 [1.53, 6.68]), and the positive association between exposure to work-site smoking bans and quitting is particularly strong for Southeast Asia (OR with 95% CI 1.20 [1.06, 1.35]) and Asia Pacific countries (OR with 95% CI 1.85 [0.93, 3.68]). Additionally, exposure to tobacco industry marketing is significantly associated with smaller odds of quitting in Asia Pacific (OR with 95% CI 0.83 [0.79, 0.87]) and Latin American countries (OR with 95% CI 0.78 [0.74, 0.82]). Although our results vary by country, they generally suggest that greater exposure to tobacco control polices is significantly associated with quitting. C1 [Shang, Ce; Chaloupka, Frank J.] Univ Illinois, Ctr Hlth Policy, Inst Hlth Res & Policy, Chicago, IL 60608 USA. [Chaloupka, Frank J.] Univ Illinois, Dept Econ, Chicago, IL 60608 USA. [Kostova, Deliana] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Shang, C (reprint author), Univ Illinois, Ctr Hlth Policy, Inst Hlth Res & Policy, Room 422,1747 W Roosevelt Rd, Chicago, IL 60608 USA. EM cshang@uic.edu RI Shang, Ce/L-3617-2016 FU Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies; Bill and Melinda Gates Foundation FX Funding for the Global Adult Tobacco Survey (GATS) is provided by the Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies. Governments of Brazil and India contributed to GATS implementation in their respective countries. The Bill and Melinda Gates Foundation provided additional funding for GATS implementation in China and for analysis. NR 26 TC 8 Z9 8 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2014 VL 16 SU 1 BP S44 EP S55 DI 10.1093/ntr/ntt179 PG 12 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 282HP UT WOS:000329161700008 PM 24343957 ER PT J AU Barradas, DT Dietz, PM Pearl, M England, LJ Callaghan, WM Kharrazi, M AF Barradas, Danielle T. Dietz, Patricia M. Pearl, Michelle England, Lucinda J. Callaghan, William M. Kharrazi, Martin TI Validation of Obstetric Estimate Using Early Ultrasound: 2007 California Birth Certificates SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE validity; gestational age; preterm ID GESTATIONAL-AGE; FETAL AGE; BIOMETRY AB BackgroundObstetric estimate (OE) of gestational age, recently added to the standard US birth certificate, has not been validated. Using early ultrasound-based gestational age (prior to 20 weeks gestation) as the criterion standard, we estimated the prevalence of preterm delivery and the sensitivity and positive predictive value (PPV) of gestational age estimates based on OE. MethodsWe analyzed 165148 singleton livebirth records (38% of California livebirths during the study period) with linked early ultrasound information from a statewide California prenatal screening programme. OE of gestational age estimates was obtained from birth certificates. ResultsPrevalence of preterm delivery (<37 weeks gestation) was higher based on early ultrasound (8.1%) compared with preterm delivery based on OE (7.1%). Sensitivity for preterm birth when using OE for gestational age was 74.9% (95% confidence interval [CI] [74.1, 75.6]), and PPV was 85.1% (95% CI [84.4, 85.7]). Incongruence, defined as a14-day difference between early-ultrasound-derived gestational age and OE, was 3.4%. ConclusionsOE reported on the birth certificate may underestimate the prevalence of preterm delivery, particularly among women of non-Hispanic non-white race and ethnicity and women with lower educational attainment, public insurance at time of delivery, and missing prepregnancy BMI. Additional validation studies in other samples of births are needed. C1 [Barradas, Danielle T.; Dietz, Patricia M.; England, Lucinda J.; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Pearl, Michelle] Sequoia Fdn, Richmond, CA USA. [Kharrazi, Martin] Calif Dept Publ Hlth, Genet Dis Screening Program, Richmond, CA USA. RP Barradas, DT (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy NE,MS K-22, Atlanta, GA 30341 USA. EM dbarradas@cdc.gov FU Intramural CDC HHS [CC999999]; NIDDK NIH HHS [T32 DK007734] NR 13 TC 6 Z9 6 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-5022 EI 1365-3016 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD JAN PY 2014 VL 28 IS 1 BP 3 EP 10 DI 10.1111/ppe.12083 PG 8 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 264RX UT WOS:000327899300002 PM 24117928 ER PT J AU Adgent, MA Hoffman, K Goldman, BD Sjodin, A Daniels, JL AF Adgent, Margaret A. Hoffman, Kate Goldman, Barbara Davis Sjoedin, Andreas Daniels, Julie L. TI Brominated Flame Retardants in Breast Milk and Behavioural and Cognitive Development at 36 Months SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE PBDEs; halogenated diphenyl ethers; flame retardants; milk; human; environment; environmental pollutant; epidemiology; neurobehavioural manifestations ID POLYBROMINATED DIPHENYL ETHERS; ACUTE POSTNATAL EXPOSURE; NEONATAL EXPOSURE; MARKET-BASKET; ENVIRONMENT; PBDES; RATS; RECEPTORS; ATTENTION; INFANTS AB BackgroundPolybrominated diphenyl ethers (PBDEs) are persistent flame retardants found in the environment, in household dust, and in humans. Breast feeding is a prominent route of exposure in infancy. PBDEs adversely affect neurodevelopment in animals. Here, we estimate associations between PBDEs in breast milk and behaviour and cognitive skills in children at 36 months of age. MethodsWe prospectively studied 304 mothers and their children. We measured PBDEs in breast milk collected at 3 months postpartum. At 36 months, we measured child behaviour with the parent-rated Behavioral Assessment System for Children 2 (n=192), and cognitive skills with the Mullen Scales of Early Learning (n=184). We analysed data with robust regression. ResultsWe detected BDE-28, -47, -99, -100, and -153 in >70% of milk samples. For each congener, the highest quartile of breast milk PBDE concentration, vs. the lowest, was associated with more anxious behaviour, after confounder adjustment. Select congeners were associated with increased withdrawal (BDE-28) and improved activity of daily living skills (BDE-153). Cognitive skills tended to be positively associated with PBDEs, especially language and fine motor skills. However, most estimates were imprecise. ConclusionsHere, lactational PBDE exposure was modestly and imprecisely associated with anxiety and withdrawal, but was also associated with improved adaptive and cognitive skills. Positive factors associated with breast feeding may have mitigated some of the hypothesised adverse neurodevelopmental outcomes associated with PBDEs. Further research is needed to inform our understanding of PBDE neurotoxicity and how sources of exposure might confound neurodevelopmental studies. C1 [Adgent, Margaret A.] NIEHS, Res Triangle Pk, NC 27709 USA. [Hoffman, Kate; Daniels, Julie L.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Goldman, Barbara Davis] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27599 USA. [Goldman, Barbara Davis] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA. [Sjoedin, Andreas] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. RP Daniels, JL (reprint author), Univ N Carolina, Dept Epidemiol, CB 7435, Chapel Hill, NC 27599 USA. EM julie_daniels@unc.edu RI Sjodin, Andreas/F-2464-2010 FU Environmental Protection Agency [RD832736]; National Institute of Environmental Health Sciences (NIEHS) [P30ES10126]; Centers for Disease Control and Prevention Foundation; NIEHS Environmental Biostatistics Training Program [T32ES007018]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences FX This research was supported in part by grants from the Environmental Protection Agency (RD832736), the National Institute of Environmental Health Sciences (NIEHS) (P30ES10126), and the Centers for Disease Control and Prevention Foundation. The work of Kate Hoffman was supported by the NIEHS Environmental Biostatistics Training Program (T32ES007018). This research was supported [in part] by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. The authors have no financial relationships relevant to this article or conflicts of interest to disclose. NR 41 TC 11 Z9 11 U1 4 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-5022 EI 1365-3016 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD JAN PY 2014 VL 28 IS 1 BP 48 EP 57 DI 10.1111/ppe.12078 PG 10 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 264RX UT WOS:000327899300007 PM 24313667 ER PT J AU Feldkamp, ML Srisukhumbowornchai, S Romitti, PA Olney, RS Richardson, SD Botto, LD AF Feldkamp, Marcia L. Srisukhumbowornchai, Sivithee Romitti, Paul A. Olney, Richard S. Richardson, Sandra D. Botto, Lorenzo D. CA Natl Birth Defects Prevention TI Self-Reported Maternal Cigarette Smoke Exposure during the Periconceptional Period and the Risk for Omphalocoele SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE cigarette smoke; maternal smoking; omphalocoele; second-hand smoke ID BIRTH-DEFECTS PREVENTION; TOBACCO-SMOKE; OROFACIAL CLEFTS; CONSUMPTION; PREGNANCY AB BackgroundWe investigated whether maternal exposure to cigarette smoke was associated with omphalocoele and whether periconceptional folic acid modified the association. Methods:We analysed data from the National Birth Defects Prevention Study on omphalocoele case (n=301) and control (n=8135) mothers for infants born from 1997 through 2007. Mothers who reported active smoking or exposure to second-hand smoke during the periconceptional period (1 month before conception to 3 months after) were considered exposed. Those who reported use of folic acid supplements during the same period were considered supplement users. Odds ratios and 95% confidence intervals were estimated using multivariable logistic regression adjusted for alcohol use, preconception body mass index, and race/ethnicity. ResultsOne hundred fifteen (38.2%) case and 2592 (31.9%) control mothers reported exposure to cigarette smoke during the periconceptional period. Adjusted odds ratios [95% confidence intervals] were 1.19 [0.94, 1.53] for any smoke exposure, 0.87 [0.54, 1.40] for active smoking, 1.38 [1.00, 1.90] for second-hand smoke exposure, and 1.16 [0.80, 1.67] for both exposures combined. No dose-response relationship was observed. Folic acid-containing supplements did not reduce the risk for omphalocoele among women with active or second-hand smoke exposure. ConclusionsSelf-reported active maternal smoking, with or without exposure to second-hand smoke, during the periconceptional period was not associated with omphalocoele. In contrast, there was a possible association with periconceptional exposure to second-hand smoke. C1 [Feldkamp, Marcia L.; Srisukhumbowornchai, Sivithee; Botto, Lorenzo D.] Univ Utah, Dept Pediat, Salt Lake City, UT 84132 USA. [Romitti, Paul A.] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA. [Olney, Richard S.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Richardson, Sandra D.] New York State Dept Hlth, Albany, NY USA. RP Feldkamp, ML (reprint author), Univ Utah, Hlth Sci Ctr, Dept Pediat, Div Med Genet, 2C 412 SOM,50 North Mario Capecchi Dr, Salt Lake City, UT 84132 USA. EM marcia.feldkamp@hsc.utah.edu FU CDC [PA 96043, PA 02081, FOA DD09-001] FX This work was supported through cooperative agreements under PA 96043, PA 02081, and FOA DD09-001 from the CDC to the Centers for Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study. NR 33 TC 4 Z9 4 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-5022 EI 1365-3016 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD JAN PY 2014 VL 28 IS 1 BP 67 EP 73 DI 10.1111/ppe.12093 PG 7 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 264RX UT WOS:000327899300009 PM 24313669 ER PT J AU Philipp, CS Faiz, AS Beckman, MG Grant, A Bockenstedt, PL Heit, JA James, AH Kulkarni, R Manco-Johnson, MJ Moll, S Ortel, TL AF Philipp, Claire S. Faiz, Ambarina S. Beckman, Michele G. Grant, Althea Bockenstedt, Paula L. Heit, John A. James, Andra H. Kulkarni, Roshni Manco-Johnson, Marilyn J. Moll, Stephan Ortel, Thomas L. TI Differences in Thrombotic Risk Factors in Black and White Women with Adverse Pregnancy Outcome SO THROMBOSIS RESEARCH LA English DT Article DE Thrombotic risk factors; thrombophilia; adverse pregnancy outcomes; racial disparities ID FACTOR-V-LEIDEN; FETAL LOSS; ANTIPHOSPHOLIPID SYNDROME; THROMBOPHILIC DISORDERS; VENOUS THROMBOEMBOLISM; COMPLICATIONS; MISCARRIAGE; MORTALITY; MUTATION; COHORT AB Introduction: Black women have an increased risk of adverse pregnancy outcomes and the characteristics of thrombotic risk factors in this population are unknown. The objective of this study was to examine the racial differences in thrombotic risk factors among women with adverse pregnancy outcomes. Methods: Uniform data were collected in women with adverse pregnancy outcomes (pregnancy losses, intrauterine growth restriction (IUGR), prematurity, placental abruption and preeclampsia) referred to Thrombosis Network Centers funded by the Centers for Disease Control and Prevention (CDC). Results: Among 343 white and 66 black women seen for adverse pregnancy outcomes, protein S and antithrombin deficiencies were more common in black women. The prevalence of diagnosed thrombophilia was higher among whites compared to blacks largely due to Factor V Leiden mutation. The prevalence of a personal history of venous thromboembolism (VTE) did not differ significantly by race. A family history of VTE, thrombophilia, and stroke or myocardial infarction (MI) was higher among whites. Black women had a higher body mass index, and a higher prevalence of hypertension, while the prevalence of sickle cell disease was approximately 27 fold higher compared to the general US black population. Conclusions: Thrombotic risk factors differ significantly in white and black women with adverse pregnancy outcomes. Such differences highlight the importance of considering race separately when assessing thrombotic risk factors for adverse pregnancy outcomes. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Philipp, Claire S.; Faiz, Ambarina S.] Rutgers Robert Wood Johnson Med Sch, Dept Med, New Brunswick, NJ 08903 USA. [Beckman, Michele G.; Grant, Althea] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA. [Bockenstedt, Paula L.] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA. [Heit, John A.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [James, Andra H.] Duke Univ, Dept Obstet & Gynecol, Durham, NC USA. [Kulkarni, Roshni] Michigan State Univ, Dept Pediat & Human Dev, E Lansing, MI 48824 USA. [Manco-Johnson, Marilyn J.] Univ Colorado, Dept Pediat, Denver, CO 80202 USA. [Manco-Johnson, Marilyn J.] Childrens Hosp, Aurora, CO USA. [Moll, Stephan] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Ortel, Thomas L.] Duke Univ, Dept Pathol & Med, Durham, NC USA. RP Philipp, CS (reprint author), Rutgers Robert Wood Johnson Med Sch, Div Hematol, MEB Rm 378, New Brunswick, NJ 08903 USA. EM philipp@rutgers.edu FU Centers for Disease Control and Prevention [DD000017, DD000235, DD000016, DD000292, DD000014, DD000015] FX This work was supported by grants from the Centers for Disease Control and Prevention (DD000017 to CP, DD000235 to JAH, DD000016 to MMJ, DD000292 to SM, DD000014 to TLO, and DD000015 to the Hemophilia Foundation of Michigan [PLB, RK]). NR 29 TC 4 Z9 4 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0049-3848 J9 THROMB RES JI Thromb. Res. PD JAN PY 2014 VL 133 IS 1 BP 108 EP 111 DI 10.1016/j.thromres.2013.10.035 PG 4 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 278TF UT WOS:000328911900019 PM 24246297 ER PT J AU Levin, ML Zemtsova, GE Montgomery, M Killmaster, LF AF Levin, M. L. Zemtsova, G. E. Montgomery, M. Killmaster, L. F. TI Effects of homologous and heterologous immunization on the reservoir competence of domestic dogs for Rickettsia conorii (israelensis) SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Rickettsia conorii; Immunization; Reservoir competence; Horizontal transmission; Rhipicephalus sanguineus ID SPOTTED-FEVER GROUP; RHIPICEPHALUS-SANGUINEUS TICKS; DERMACENTOR-VARIABILIS TICK; MOLECULAR-DETECTION; CROSS-PROTECTION; NATURAL-HISTORY; SP-NOV; MASSILIAE; INFECTION; SUSCEPTIBILITY AB A number of spotted fever group (SFG) rickettsiae cause serious infections in humans. Several antigenically related rickettsial agents may coexist within the same geographical area, and humans or vertebrate hosts may be sequentially exposed to multiple SFG agents. We assessed whether exposure of a vertebrate reservoir to one SFG Rickettsia will affect the host's immune response to a related pathogen and the efficiency of transmission to uninfected ticks. Two pairs of dogs were each infected with either Rickettsia massiliae or Rickettsia conorii israelensis, and their immune response was monitored twice weekly by IFA. The four immunized dogs and a pair of naive dogs were each challenged with R. conorii israelensis-infected Rhipicephalus sanguineus nymphs. Uninfected Rh. sanguineus larvae were acquisition-fed on the dogs on days 1, 7, and 14 post-challenge. These ticks were tested for the presence of rickettsial DNA after molting to the nymphal stage. The naive dogs became infected with R. conorii israelensis and were infectious to ticks for at least 3 weeks, whereas reservoir competence of dogs previously infected with either R. massiliae or R. conorii was significantly diminished. This opens an opportunity for decreasing the efficiency of transmission and propagation of pathogenic Rickettsia in natural foci by immunizing the primary hosts with closely related nonpathogenic SFG bacteria. However, neither homologous immunization nor cross-immunization significantly affected the efficiency of R. conorii transmission between cofeeding infected nymphs and uninfected larvae. At high densities of ticks, the efficiency of cofeeding transmission may be sufficient for yearly amplification and persistent circulation of a rickettsial pathogen in the vector population. Published by Elsevier GmbH. C1 [Levin, M. L.; Zemtsova, G. E.; Montgomery, M.; Killmaster, L. F.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. RP Levin, ML (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, 1600 Clifton Rd,MS G-13, Atlanta, GA 30333 USA. EM MLevin@cdc.gov NR 58 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2014 VL 5 IS 1 BP 33 EP 40 DI 10.1016/j.ttbdis.2013.07.010 PG 8 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA 280CW UT WOS:000329007300006 PM 24201056 ER PT J AU Kostova, D Chaloupka, FJ Yurekli, A Ross, H Cherukupalli, R Andes, L Asma, S AF Kostova, Deliana Chaloupka, Frank J. Yurekli, Ayda Ross, Hana Cherukupalli, Rajeev Andes, Linda Asma, Samira CA GATS Collaborative Grp TI A cross-country study of cigarette prices and affordability: evidence from the Global Adult Tobacco Survey SO TOBACCO CONTROL LA English DT Article ID SMOKING AB Objective To describe the characteristics of two primary determinants of cigarette consumption: cigarette affordability and the range of prices paid for cigarettes (and bidis, where applicable) in a set of 15 countries. From this cross-country comparison, identify places where opportunities may exist for reducing consumption through tax adjustments. Data Self-response data from 45,838 smokers from 15 countries, obtained from the Global Adult Tobacco Survey (GATS) 2008-2011. Design Using self-response data on individual cigarette expenditure and consumption, we construct a measure of the average cigarette price smokers pay for manufactured cigarettes (and bidis, where applicable) in 15 countries. We use these prices to evaluate cigarette affordability and the range of prices available in each country. These survey-derived measures of cigarette price and affordability are uniquely suited for cross-country comparison because they represent each country's distinctive mix of individual consumption characteristics such as brand choice, intensity of consumption, and purchasing behavior. Results In this sample of countries, cigarettes are most affordable in Russia, which has the most room for tobacco tax increase. Affordability is also relatively high in Brazil and China for cigarettes, and in India and Bangladesh for bidis. Although the affordability of cigarettes in India is relatively low, the range of cigarette prices paid is relatively high, providing additional evidence to support the call for simplifying the existing tax structure and reducing the width of price options. China has both high affordability and wide price ranges, suggesting multiple opportunities for reducing consumption through tax adjustments. C1 [Kostova, Deliana; Andes, Linda; Asma, Samira] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Chaloupka, Frank J.] Univ Illinois, Ctr Hlth Policy, Chicago, IL USA. [Yurekli, Ayda] World Hlth Org, Geneva, Switzerland. [Ross, Hana] Amer Canc Soc, Atlanta, GA 30329 USA. [Cherukupalli, Rajeev] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Kostova, D (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F16, Atlanta, GA 30341 USA. EM kiv0@cdc.gov NR 17 TC 12 Z9 12 U1 2 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0964-4563 EI 1468-3318 J9 TOB CONTROL JI Tob. Control PD JAN PY 2014 VL 23 IS 1 AR e3 DI 10.1136/tobaccocontrol-2011-050413 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273QJ UT WOS:000328550800004 PM 22923477 ER PT J AU Rider, CV Boekelheide, K Catlin, N Gordon, CJ Morata, T Selgrade, MK Sexton, K Simmons, JE AF Rider, Cynthia V. Boekelheide, Kim Catlin, Natasha Gordon, Christopher J. Morata, Thais Selgrade, MaryJane K. Sexton, Kenneth Simmons, Jane Ellen TI Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors SO TOXICOLOGICAL SCIENCES LA English DT Article DE cumulative risk; nonchemical stressors; joint action; radiation; infectious disease; sunlight; temperature; noise ID INDUCED HEARING-LOSS; GERM-CELL APOPTOSIS; CARBON-MONOXIDE; CYTOMEGALOVIRUS-INFECTION; INCREASED SUSCEPTIBILITY; INFLAMMATORY RESPONSES; INFLUENZA INFECTION; INDUCED HYPOTHERMIA; NOISE ANNOYANCE; EXPOSURE AB Recent efforts to update cumulative risk assessment procedures to incorporate nonchemical stressors ranging from physical to psychosocial reflect increased interest in consideration of the totality of variables affecting human health and the growing desire to develop community-based risk assessment methods. A key roadblock is the uncertainty as to how nonchemical stressors behave in relationship to chemical stressors. Physical stressors offer a reasonable starting place for measuring the effects of nonchemical stressors and their modulation of chemical effects (and vice versa), as they clearly differ from chemical stressors; and doses of many physical stressors are more easily quantifiable than those of psychosocial stressors. There is a commonly held belief that virtually nothing is known about the impact of nonchemical stressors on chemically mediated toxicity or the joint impact of coexposure to chemical and nonchemical stressors. Although this is generally true, there are several instances where a substantial body of evidence exists. A workshop titled Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors held at the 2013 Society of Toxicology Annual Meeting provided a forum for discussion of research addressing the toxicity of physical stressors and what is known about their interactions with chemical stressors, both in terms of exposure and effects. Physical stressors including sunlight, heat, radiation, infectious disease, and noise were discussed in reference to identifying pathways of interaction with chemical stressors, data gaps, and suggestions for future incorporation into cumulative risk assessments. C1 [Rider, Cynthia V.] NIEHS, Div Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Boekelheide, Kim; Catlin, Natasha] Brown Univ, Providence, RI 02912 USA. [Gordon, Christopher J.] US EPA, Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Morata, Thais] NIOSH, Integrated Syst Toxicol Div, Cincinnati, OH 45226 USA. [Selgrade, MaryJane K.] ICF Int, Durham, NC 27713 USA. [Sexton, Kenneth] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Simmons, Jane Ellen] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Rider, CV (reprint author), NIEHS, 111 TW Alexander Dr,POB 12233,MD K2-12, Res Triangle Pk, NC 27709 USA. EM ridercv@niehs.nih.gov FU Superfund Research Program grant [P42ES013660]; Training grant [T32ES07272]; National Institute of Health, National Institute of Environmental Health Sciences FX Superfund Research Program grant (P42ES013660 to K. B.); Training grant (NC; T32ES07272); the Intramural Research Program of the National Institute of Health, National Institute of Environmental Health Sciences. NR 54 TC 6 Z9 6 U1 3 U2 21 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2014 VL 137 IS 1 BP 3 EP 11 DI 10.1093/toxsci/kft228 PG 9 WC Toxicology SC Toxicology GA 281XD UT WOS:000329133400002 PM 24154487 ER PT J AU Feelemyer, J Des Jarlais, D Arasteh, K Abdul-Quader, AS Hagan, H AF Feelemyer, Jonathan Des Jarlais, Don Arasteh, Kamyar Abdul-Quader, Abu S. Hagan, Holly TI Retention of participants in medication-assisted programs in low- and middle-income countries: an international systematic review SO ADDICTION LA English DT Review DE Buprenorphine; developing countries; low- and middle-income countries; methadone; opiate abuse; opiate substitution programs ID METHADONE-MAINTENANCE TREATMENT; INJECTION-DRUG USERS; QUALITY-OF-LIFE; TRADITIONAL CHINESE MEDICINE; CONTROLLED-TRIAL; BUPRENORPHINE MAINTENANCE; SUBSTITUTION THERAPY; HEROIN DEPENDENCE; OPIOID DEPENDENCE; SUBSTANCE USE AB Background and aimsMedication-assisted treatment (MAT) is a key component in overdose prevention, reducing illicit opiate use and risk of blood-borne virus infection. By retaining participants in MAT programs for longer periods of time, more noticeable and permanent changes in drug use, risk behavior and quality of life can be achieved. Many studies have documented retention in MAT programs in high-income countries, using a 50% average 12-month follow-up retention rate as a marker for a successful MAT program. This study contributes to a systematic understanding of how successful programs have been in retaining participants in low- and middle-income countries (LMIC) over time. MethodsUsing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic literature search to identify MAT program studies that documented changes in retention over time for participants in buprenorphine and methadone programs in LMIC. Retention was measured for participants by length of follow-up, type of MAT and treatment dosage. ResultsThere were 58 MAT program studies, with 27047 participants eligible for inclusion in the review. Overall average retention after 12 months was 54.3% [95% confidence interval (CI)=46.2, 63.7%]. Overall average retention was moderately good for both buprenorphine (48.3%, 95% CI=22.1, 74.6%) and methadone (56.6%, 95% CI=45.9%, 67.3%) after 12 months of treatment. Among programs using methadone there was no statistically significant difference in average retention by dosage level, and the 10 highest and lowest dosage programs obtained similar average retention levels after 12 months. ConclusionMedication-assisted treatment programs in low- and middle-income countries achieve an average 50% retention rate after 12 months, with wide variation across programs but little difference between those using buprenorphine versus methadone. C1 [Feelemyer, Jonathan; Des Jarlais, Don; Arasteh, Kamyar] Beth Israel Deaconess Med Ctr, Baron Edmond Rothschild Chem Dependency Inst, New York, NY 10038 USA. [Abdul-Quader, Abu S.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. [Hagan, Holly] NYU, Coll Nursing, New York, NY USA. RP Feelemyer, J (reprint author), Beth Israel Deaconess Med Ctr, Baron Edmond Rothschild Chem Dependency Inst, 160 Water St,FL 24, New York, NY 10038 USA. EM jfeelemyer@chpnet.org FU NIAID NIH HHS [R01 AI083035]; NIDA NIH HHS [P30 DA011041] NR 109 TC 7 Z9 7 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0965-2140 EI 1360-0443 J9 ADDICTION JI Addiction PD JAN PY 2014 VL 109 IS 1 BP 20 EP 32 DI 10.1111/add.12303 PG 13 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 268GD UT WOS:000328157300005 PM 23859638 ER PT J AU Charles, LE Andrew, ME Sarkisian, K Li, SQ Mnatsakanova, A Violanti, JM Wilson, M Gu, JK Miller, DB Burchfiel, CM AF Charles, Luenda E. Andrew, Michael E. Sarkisian, Khachatur Li, Shengqiao Mnatsakanova, Anna Violanti, John M. Wilson, Mark Gu, Ja K. Miller, Diane B. Burchfiel, Cecil M. TI Associations Between Insulin and Heart Rate Variability in Police Officers SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID SYMPATHETIC-NERVE ACTIVITY; ARCUATE NUCLEUS; AUTONOMIC REGULATION; BLOOD-PRESSURE; DISEASE; HYPERINSULINEMIA; GLUCOSE; SYSTEM; PREDICTORS; ACTIVATION AB ObjectiveLow heart rate variability (HRV) has been linked to cardiovascular disease. Our objective was to examine the cross-sectional association between insulin and HRV. MethodsInsulin levels were measured in 355 nondiabetic officers from the BCOPS study, following a 12 h fast. HRV was performed according to methods published by the task force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high (HF) and low frequency (LF) HRV were compared across tertiles of insulin using ANOVA and ANCOVA; p-values were obtained from linear regression models. ResultsHigher mean levels of insulin were significantly associated with lower (i.e., worse) mean levels of HRV before and after risk-factor adjustment. The results for HF HRV (ms(2)) were as follows: 1st insulin (mu U/ml) tertile (156.3; 95% confidence interval (CI)=128.6-189.9); 2nd tertile (154.3; 95% CI=124.3-191.5); 3rd tertile (127.9; 95% CI=105.0-155.8), p for trend=0.017. Results with LF HRV were similar to HF HRV. Insulin was also inversely and significantly associated with HRV among officers with BMI 25 kg/m(2), with 25.5% body fat, and among those who reported low (= 1 seasonal influenza vaccination in Year 1 (20092010) and Year 2 (2010-2011) were collected on all student grades K through 5 at intervention and control schools from the IIS in the Spring of 2010 and 2011, respectively. Additionally, coverage achieved through SLV-I was compared to coverage of children vaccinated elsewhere. Preliminary data analysis for Year 1 occurred in Spring 2010; final quantitative analysis for both years was completed in late Fall 2012. Results: Results are shown for 2009-2010 and 2010-2011, respectively: Children enrolled in suburban SLV-I versus control schools had vaccination coverage of 47% vs 36%, and 52% vs 36% (p<0.0001 both years). In urban areas, coverage was 36% vs 26%, and 31% vs 25% (p<0.001 both years). On multilevel logistic analysis with three nested levels (student, school, school district) during both vaccination seasons, children were more likely to be vaccinated in SLV-I versus control schools; ORs were 1.6 (95% CI=1.4, 1.9; p < 0.001) and 1.5 (95% CI=1.3, 1.8; p<0.001). Conclusions: Delivering influenza vaccine during school is a promising approach to improving pediatric influenza vaccination coverage. (C) 2014 Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Humiston, Sharon G.] Childrens Mercy Hosp & Clin, Dept Pediat, Kansas City, MO 64108 USA. [Schaffer, Stanley J.; Szilagyi, Peter G.; Blumkin, Aaron K.] Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA. [Long, Christine E.; Chappel, Tahleah R.] Univ Rochester, Med Ctr, Ctr Community Hlth, Rochester, NY 14642 USA. [Szydlowski, Jill] Univ Rochester, Med Ctr, Div Hlth Policy & Outcomes Res, Rochester, NY 14642 USA. [Kolasa, Maureen S.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Hlth Serv Res & Evaluat Branch, Atlanta, GA USA. RP Humiston, SG (reprint author), Childrens Mercy Hosp & Clin, Div Emergency & Urgent Care, 2401 Gillham Rd, Kansas City, MO 64108 USA. EM sghumiston@cmh.edu OI Schaffer, Stanley/0000-0001-7993-1374 FU CDC National Center for Immunization and Respiratory Diseases (CDC NCIRD) [055215-002]; School-Based Influenza Immunization Program FX This study was supported by the CDC National Center for Immunization and Respiratory Diseases (CDC NCIRD) Grant 055215-002, "School-Based Influenza Immunization Program." This support did not include the purchase of any vaccine. The CDC NCIRD Project Officer, Mrs. Kolasa, met with the team regularly and contributed to the study design, implementation, analysis, and manuscript preparation. The authors wish to thank Dr. Andrew Doniger, William Russell, Kim DiMattia, and the many school personnel who helped implement the school located vaccination program. NR 49 TC 7 Z9 7 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2014 VL 46 IS 1 BP 1 EP 9 DI 10.1016/j.amepre.2013.08.021 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 277DO UT WOS:000328799300001 PM 24355665 ER PT J AU Rao, JK Anderson, LA Lin, FC Laux, JP AF Rao, Jaya K. Anderson, Lynda A. Lin, Feng-Chang Laux, Jeffrey P. TI Completion of Advance Directives Among US Consumers SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID COMMUNITY-DWELLING ELDERS; OF-LIFE ISSUES; END; CARE; COMMUNICATION; PREFERENCES AB Background: Current, ongoing national surveys do not include questions about end-of-life (EOL) issues. In particular, population-based data are lacking regarding the factors associated with advance directive completion. Purpose: To characterize U.S. adults who did and did not have an advance directive and examine factors associated with their completion, such as the presence of a chronic condition and regular source of health care. Methods: Data were analyzed in 2013 from adults aged 18 years and older who participated in the 2009 or 2010 Health Styles Survey, a mail panel survey designed to be representative of the U.S. population. Likelihood ratio tests were used to examine the associations between advance directive completion and demographic and socioeconomic variables (education, income, employment status); presence of a chronic condition; regular source of health care; and self-reported EOL concerns or discussions. Multiple logistic regression analyses identified independent predictors related to advance directive completion. Results: Of the 7946 respondents, 26.3% had an advance directive. The most frequently reported reason for not having one was lack of awareness. Advance directive completion was associated with older age, more education, and higher income and was less frequent among non-white respondents. Respondents with advance directives also were more likely to report having a chronic disease and a regular source of care. Advance directives were less frequent among those who reported not knowing if they had an EOL concern. Conclusions: These data indicate racial and educational disparities in advance directive completion and highlight the need for education about their role in facilitating EOL decisions. C1 [Rao, Jaya K.] Univ N Carolina, Gillings Sch Global Publ Hlth, Div Pharmaceut Outcomes & Policy, Chapel Hill, NC USA. [Lin, Feng-Chang; Laux, Jeffrey P.] Univ N Carolina, Gillings Sch Global Publ Hlth, Eshelman Sch Pharm, Dept Biostat, Chapel Hill, NC USA. [Anderson, Lynda A.] CDC, Div Populat Hlth, Appl Res & Translat Branch, Hlth Aging Program, Atlanta, GA 30333 USA. [Anderson, Lynda A.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Anderson, LA (reprint author), CDC, Div Populat Hlth, MS F78, 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM laa0@cdc.gov FU Intramural CDC HHS [CC999999] NR 31 TC 41 Z9 41 U1 3 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2014 VL 46 IS 1 BP 65 EP 70 DI 10.1016/j.amepre.2013.09.008 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 277DO UT WOS:000328799300009 PM 24355673 ER PT J AU Ekwueme, DU Guy, GP Rim, SH White, A Hall, IJ Fairley, TL Dean, HD AF Ekwueme, Donatus U. Guy, Gery P., Jr. Rim, Sun Hee White, Arica Hall, Ingrid J. Fairley, Temeika L. Dean, Hazel D. TI Health and Economic Impact of Breast Cancer Mortality in Young Women, 1970-2008 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SERVICES TASK-FORCE; UNITED-STATES; SCREENING MAMMOGRAPHY; PRODUCTIVITY COSTS; WHITE WOMEN; BLACK-WOMEN; AGE; PROGNOSIS; SURVIVAL; DIAGNOSIS AB Background: Breast cancer is the second-leading cause of cancer-related deaths among women aged <50 years. Studies on the effects of breast cancer mortality among young women are limited. Purpose: To assess trends in breast cancer mortality rates among women aged 20-49 years, estimate years of potential life lost (YPLL), and the value of productivity losses due to premature mortality. Methods: Age-adjusted rates and rate ratios (RRs) were calculated using 1970-2008 U.S. mortality data. Breast cancer mortality rates over time were assessed using Joinpoint regression modeling. YPLL was calculated using number of cancer deaths and the remaining life expectancy at the age of death. Value of productivity losses was estimated using the number of deaths and the present value of future lifetime earnings. Results: From 1970 to 2008, the age-adjusted breast cancer mortality rate among young women was 12.02/100,000. Rates were higher in the Northeast (RR=1.03, 95% CI, 1.02-1.04). The annual decline in breast cancer mortality rates among blacks was smaller (-0.68%) compared with whites (-2.02%). The total number of deaths associated with breast cancer was 225,866, which accounted for an estimated 7.98 million YPLL. The estimated total productivity loss in 2008 was $5.49 billion and individual lifetime lost earnings were $1.10 million. Conclusions: Considering the effect of breast cancer on women of working age and the disproportionate impact on black women, more age-appropriate interventions with multiple strategies are needed to help reduce these substantial health and economic burdens, improve survival, and in turn reduce productivity costs associated with premature death. C1 [Ekwueme, Donatus U.; Guy, Gery P., Jr.; Rim, Sun Hee; White, Arica; Hall, Ingrid J.; Fairley, Temeika L.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Dean, Hazel D.] Ctr Dis Control & Prevent, Natl Ctr HIV,AIDS,Viral Hepatitis,STD & TB Preven, Off Director, Atlanta, GA 30341 USA. RP Ekwueme, DU (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,Chamblee Bldg 107,MS F-76,Flo, Atlanta, GA 30341 USA. EM dce3@cdc.gov NR 53 TC 12 Z9 12 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2014 VL 46 IS 1 BP 71 EP 79 DI 10.1016/j.amepre.2013.08.016 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 277DO UT WOS:000328799300010 PM 24355674 ER PT J AU Roy, SL Metzger, R Chen, JG Laham, FR Martin, M Kipper, SW Smith, LE Lyon, GM Haffner, J Ross, JE Rye, AK Johnson, W Bodager, D Friedman, M Walsh, DJ Collins, C Inman, B Davis, BJ Robinson, T Paddock, C Zaki, SR Kuehnert, M DaSilva, A Qvarnstrom, Y Sriram, R Visvesvara, GS AF Roy, S. L. Metzger, R. Chen, J. G. Laham, F. R. Martin, M. Kipper, S. W. Smith, L. E. Lyon, G. M., III Haffner, J. Ross, J. E. Rye, A. K. Johnson, W. Bodager, D. Friedman, M. Walsh, D. J. Collins, C. Inman, B. Davis, B. J. Robinson, T. Paddock, C. Zaki, S. R. Kuehnert, M. DaSilva, A. Qvarnstrom, Y. Sriram, R. Visvesvara, G. S. TI Risk for Transmission of Naegleria fowleri From Solid Organ Transplantation SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE Ameba; amoeba; disseminated; Naegleria; primary amebic meningoencephalitis; transplant ID PRIMARY AMEBIC MENINGOENCEPHALITIS; BALAMUTHIA-MANDRILLARIS; ACANTHAMOEBA SPP.; DONOR; VIRUS; MICE AB Primary amebic meningoencephalitis (PAM) caused by the free-living ameba (FLA) Naegleria fowleri is a rare but rapidly fatal disease of the central nervous system (CNS) affecting predominantly young, previously healthy persons. No effective chemotherapeutic prophylaxis or treatment has been identified. Recently, three transplant-associated clusters of encephalitis caused by another FLA, Balamuthia mandrillaris, have occurred, prompting questions regarding the suitability of extra-CNS solid organ transplantation from donors with PAM. During 1995-2012, 21 transplant recipients of solid organs donated by five patients with fatal cases of PAM were reported in the United States. None of the recipients developed PAM, and several recipients tested negative for N. fowleri by serology. However, historical PAM case reports and animal experiments with N. fowleri, combined with new postmortem findings from four patients with PAM, suggest that extra-CNS dissemination of N. fowleri can occur and might pose a risk for disease transmission via transplantation. The risks of transplantation with an organ possibly harboring N. fowleri should be carefully weighed for each individual recipient against the potentially greater risk of delaying transplantation while waiting for another suitable organ. In this article, we present a case series and review existing data to inform such risk assessments. Although Naegleria fowleri solid organ transplant transmission has not been reported to date, human postmortem findings and animal studies suggest that N. fowleri extra-CNS dissemination can occur; therefore the risks of transplantation with an organ from a patient with primary amebic meningoencephalitis should be carefully weighed against the potentially greater risk of delaying transplantation while waiting for another suitable organ. C1 [Roy, S. L.; Paddock, C.; Zaki, S. R.; Kuehnert, M.; DaSilva, A.; Qvarnstrom, Y.; Sriram, R.; Visvesvara, G. S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Metzger, R.; Johnson, W.] TransLife Organ Procurement Org, Winter Pk, FL USA. [Metzger, R.] Florida Hosp Med Ctr, Dept Transplantat, Orlando, FL 32803 USA. [Chen, J. G.; Laham, F. R.; Martin, M.] Arnold Palmer Hosp Children, Orlando, FL USA. [Kipper, S. W.] Sedgwick Cty Reg Forens Sci Ctr, Wichita, KS USA. [Smith, L. E.] Wesley Med Ctr, Wichita, KS USA. [Lyon, G. M., III] Emory Univ, Sch Med, Atlanta, GA USA. [Haffner, J.] Tampa Gen Hosp, Tampa, FL 33606 USA. [Ross, J. E.] Newberry Pathol Associates, Newberry, SC USA. [Rye, A. K.] Univ S Carolina, Sch Med, Columbia, SC USA. [Bodager, D.; Friedman, M.] Florida Dept Hlth, Tallahassee, FL USA. [Walsh, D. J.] Orange Cty Hlth Dept, Orlando, FL USA. [Collins, C.] Polk Cty Hlth Dept, Bartow, FL USA. [Inman, B.] Brevard Cty Hlth Dept, Viera, FL USA. [Davis, B. J.] Essentia Hlth, Duluth, MN USA. [Robinson, T.] Minnesota Dept Hlth, St Paul, MN USA. RP Roy, SL (reprint author), Ctr Dis Control & Prevent, Atlanta, GA USA. EM str2@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 2 Z9 2 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JAN PY 2014 VL 14 IS 1 BP 163 EP 171 DI 10.1111/ajt.12536 PG 9 WC Surgery; Transplantation SC Surgery; Transplantation GA 274HR UT WOS:000328597900021 PM 24279908 ER PT J AU Barbour, KE Hootman, JM Helmick, CG Murphy, LB Theis, KA Schwartz, TA Kalsbeek, WD Renner, JB Jordan, JM AF Barbour, K. E. Hootman, J. M. Helmick, C. G. Murphy, L. B. Theis, Kristina A. Schwartz, T. A. Kalsbeek, W. D. Renner, J. B. Jordan, J. M. TI Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study SO ARTHRITIS CARE & RESEARCH LA English DT Article ID UNITED-STATES; CENSORED-DATA; EXERCISE; QUESTIONNAIRE; PREVALENCE; ARTHRITIS; IMPACT AB ObjectiveKnee osteoarthritis (OA) is a leading cause of disability and joint pain. Although other risk factors of knee OA have been identified, how physical activity affects incident knee OA remains unclear. MethodsUsing data from the first (1999-2004) and second (2005-2010) followup periods of the Johnston County Osteoarthritis Project study, we tested the association between meeting physical activity guidelines and incident knee outcomes among 1,522 adults ages 45 years. The median followup time was 6.5 years (range 4.0-10.2 years). Physical activity at baseline (moderate-equivalent physical activity minutes/week) was calculated using the Minnesota Leisure Time Physical Activity questionnaire. Incident knee radiographic OA (ROA) was defined as the development of Kellgren/Lawrence grade 2 in a knee at followup. Incident knee symptomatic ROA (sROA) was defined as the development of ROA and symptoms in at least 1 knee at followup. Weibull regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for interval-censored data. ResultsIn multivariable models, meeting the 2008 Department of Health and Human Services (HHS) physical activity guidelines (150 minutes/week) was not significantly associated with ROA (HR 1.20 [95% CI 0.92-1.56]) or sROA (HR 1.24 [95% CI 0.87-1.76]). Adults in the highest level (300 minutes/week) of physical activity had a higher risk of knee ROA and sROA compared with inactive (0 to <10 minutes/week) participants; however, these associations were not statistically significant (HR 1.62 [95% CI 0.97-2.68] and HR 1.42 [95% CI 0.76-2.65], respectively). ConclusionMeeting the HHS physical activity guidelines was not associated with incident knee ROA or sROA in a cohort of middle-aged and older adults. C1 [Barbour, K. E.; Hootman, J. M.; Helmick, C. G.; Murphy, L. B.; Theis, Kristina A.] Ctr Dis Control & Prevent, Atlanta, GA 30345 USA. [Schwartz, T. A.; Kalsbeek, W. D.; Renner, J. B.; Jordan, J. M.] Univ N Carolina, Chapel Hill, NC USA. RP Barbour, KE (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop K-51, Atlanta, GA 30345 USA. EM iyk1@cdc.gov OI Schwartz, Todd/0000-0002-0232-2543 FU Centers for Disease Control and Prevention/Association of Schools of Public Health [S043, S1734, S3486]; National Institute of Arthritis and Musculoskeletal and Skin Diseases Multipurpose Arthritis and Musculoskeletal Disease Center [5-P60-AR30701]; National Institute of Arthritis and Musculoskeletal and Skin Diseases Multidisciplinary Clinical Research Center [5-P60-AR49465-03] FX The Johnston County Osteoarthritis Project was supported in part by the Centers for Disease Control and Prevention/Association of Schools of Public Health (cooperative agreements S043, S1734, and S3486), the National Institute of Arthritis and Musculoskeletal and Skin Diseases Multipurpose Arthritis and Musculoskeletal Disease Center (grant 5-P60-AR30701), and the National Institute of Arthritis and Musculoskeletal and Skin Diseases Multidisciplinary Clinical Research Center (grant 5-P60-AR49465-03). NR 30 TC 14 Z9 14 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2151-464X EI 2151-4658 J9 ARTHRIT CARE RES JI Arthritis Care Res. PD JAN PY 2014 VL 66 IS 1 BP 139 EP 146 DI 10.1002/acr.22120 PG 8 WC Rheumatology SC Rheumatology GA 277DF UT WOS:000328798400021 PM 23983187 ER PT J AU Callaghan, WM Prefumo, F AF Callaghan, W. M. Prefumo, F. TI Commentary on 'Pregnancy week at delivery and the risk of shoulder dystocia: a population study of 2 014 956 deliveries' SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY LA English DT Editorial Material C1 [Callaghan, W. M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30329 USA. [Prefumo, F.] Univ Brescia, Dept Obstet & Gynaecol, Maternal Fetal Med Unit, Brescia, Italy. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30329 USA. FU Intramural CDC HHS [CC999999] NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1470-0328 EI 1471-0528 J9 BJOG-INT J OBSTET GY JI BJOG PD JAN PY 2014 VL 121 IS 1 BP 42 EP 42 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 275AQ UT WOS:000328647800005 PM 26436155 ER PT J AU Christensen, D Braun, KVN Doernberg, NS Maenner, MJ Arneson, CL Durkin, MS Benedict, RE Kirby, RS Wingate, MS Fitzgerald, R Yeargin-Allsopp, M AF Christensen, Deborah Braun, Kim Van Naarden Doernberg, Nancy S. Maenner, Matthew J. Arneson, Carrie L. Durkin, Maureen S. Benedict, Ruth E. Kirby, Russell S. Wingate, Martha S. Fitzgerald, Robert Yeargin-Allsopp, Marshalyn TI Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor functioning - Autism and Developmental Disabilities Monitoring Network, USA, 2008 SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY LA English DT Article ID UNITED-STATES; CHILDREN; CLASSIFICATION; EUROPE AB AimThe aim of this study was to report the prevalence and characteristics of children with cerebral palsy (CP). MethodChildren with CP (n=451) were ascertained by the Autism and Developmental Disabilities Monitoring (ADDM) Network, a population-based, record-review surveillance system monitoring CP in four areas of the USA. Prevalence was calculated as the number of children with CP among all 8-year-old children residing in these areas in 2008. Motor function was categorized by Gross Motor Function Classification System level and walking ability. Co-occurring autism spectrum disorders (ASD) and epilepsy were ascertained using ADDM Network surveillance methodology. ResultsThe period prevalence of CP for 2008 was 3.1 per 1000 8-year-old children (95% confidence interval 2.8-3.4). Approximately 58% of children walked independently. Co-occurring ASD frequency was 6.9% and was higher (18.4%) among children with non-spastic CP, particularly hypotonic CP. Co-occurring epilepsy frequency was 41% overall, did not differ by ASD status or CP subtype, and was highest (67%) among children with limited or no walking ability. InterpretationThe prevalence of CP in childhood from US surveillance data has remained relatively constant, in the range of 3.1 to 3.6 per 1000, since 1996. The higher frequency of ASD in non-spastic than in spastic subtypes of CP calls for closer examination. This article is commented on by Zwaigenbaum on pages of this issue. C1 [Christensen, Deborah; Braun, Kim Van Naarden; Doernberg, Nancy S.; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Maenner, Matthew J.; Arneson, Carrie L.; Durkin, Maureen S.; Benedict, Ruth E.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA. [Maenner, Matthew J.; Durkin, Maureen S.] Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI USA. [Benedict, Ruth E.] Univ Wisconsin, Dept Kinesiol, Occupat Therapy Program, Madison, WI USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA. [Wingate, Martha S.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Hlth Care Org & Policy, Birmingham, AL 35294 USA. [Fitzgerald, Robert] Washington Univ, Dept Psychiat, St Louis, MO USA. RP Christensen, D (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA. EM dqc3@cdc.gov RI Durkin, Maureen/B-7834-2015 FU NICHD NIH HHS [P30 HD003352] NR 23 TC 42 Z9 44 U1 3 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0012-1622 EI 1469-8749 J9 DEV MED CHILD NEUROL JI Dev. Med. Child Neurol. PD JAN PY 2014 VL 56 IS 1 BP 59 EP 65 DI 10.1111/dmcn.12268 PG 7 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 267WG UT WOS:000328128400013 PM 24117446 ER PT J AU Rogowski, WH Grosse, SD Schmidtke, J Marckmann, G AF Rogowski, Wolf H. Grosse, Scott D. Schmidtke, Joerg Marckmann, Georg TI Criteria for fairly allocating scarce health-care resources to genetic tests: which matter most? SO EUROPEAN JOURNAL OF HUMAN GENETICS LA English DT Article DE health-care prioritization; genetic testing; costs and cost analysis; resource allocation; ethics ID COST-EFFECTIVENESS ANALYSIS; TECHNOLOGY-ASSESSMENT; PRENATAL-DIAGNOSIS; SERVICES; EQUITY; PERSPECTIVES; PRINCIPLES; DISORDERS; GERMANY; EUROPE AB The use of genetic tests is expanding rapidly. Given limited health-care budgets throughout Europe and few national coverage decisions specifically for genetic tests, decisions about allocating scarce resources to genetic tests are frequently ad hoc and left to lower-level decision makers. This study assesses substantive ethical and economic criteria to prioritize genetic services in a reasonable and fair manner. Principles for allocating health-care resources can be classified into four categories: need-based allocation; maximizing total benefits; treating people equally; and promoting and rewarding social usefulness. In the face of scarcity, the degree of an individual's need for medical intervention is an important criterion. Also, different economic concepts of efficiency are of relevance in the theory and practice of prioritizing genetic tests. Equity concerns are most likely to be relevant in terms of avoiding undesirable inequities, which may also set boundaries to the use of efficiency as a prioritization criterion. The aim of promoting and rewarding social usefulness is unlikely to be relevant to the question of what priority a genetic test should have in clinical practice. Further work is needed to select an appropriate set of criteria; operationalize them; and assign weights before some kind of standardized priority information can be added to information sources for genetic services. Besides the substantive criteria, formal considerations like those pointed out in the framework of accountability for reasonableness need to be considered in decision making. C1 [Rogowski, Wolf H.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany. [Rogowski, Wolf H.] Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Ctr Clin, Munich, Germany. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Schmidtke, Joerg] Hannover Med Sch, Inst Human Genet, Hannover, Germany. [Marckmann, Georg] Univ Munich, Inst Eth Hist & Theory Med, Munich, Germany. RP Rogowski, WH (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. EM rogowski@helmholtz-muenchen.de FU EuroGentest, an EU [512148]; EuroGentest2 [261469] FX We acknowledge the comments from various colleagues, especially Per Carlsson, Jurgen John, Helena Kaariainen, Alastair Kent, Michael Krawczak, Ulf Kristofferson and Irma Nippert. All errors of omission and commission remain our own. The study was partly supported by EuroGentest, an EU FP6 supported NoE Contract Number 512148 (EuroGentest Unit 3: Clinical genetics, community genetics and public health, Workpackage 3.2 (J Schmidtke)) and its successor EuroGentest2 (contract number 261469). NR 56 TC 9 Z9 9 U1 4 U2 16 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1018-4813 EI 1476-5438 J9 EUR J HUM GENET JI Eur. J. Hum. Genet. PD JAN PY 2014 VL 22 IS 1 BP 25 EP 31 DI 10.1038/ejhg.2013.172 PG 7 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA 275PP UT WOS:000328689600011 PM 23921536 ER PT J AU Zolotusca, L Jorgensen, P Popovici, O Pistol, A Popovici, F Widdowson, MA Alexandrescu, V Ivanciuc, A Cheng, PY Gross, D Brown, CS Mott, JA AF Zolotusca, Laurentiu Jorgensen, Pernille Popovici, Odette Pistol, Adriana Popovici, Florin Widdowson, Marc-Alain Alexandrescu, Viorel Ivanciuc, Alina Cheng, Po-Yung Gross, Diane Brown, Caroline S. Mott, Joshua A. TI Risk factors associated with fatal influenza, Romania, October 2009-May 2011 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Influenza; risk factors; Romania; severe acute respiratory illness; surveillance ID H1N1 INFLUENZA; UNITED-STATES; WOMEN AB Background Limited data are available from Central and Eastern Europe on risk factors for severe complications of influenza. Such data are essential to prioritize prevention and treatment resources and to adapt influenza vaccination recommendations. Objectives To use sentinel surveillance data to identify risk factors for fatal outcomes among hospitalized patients with severe acute respiratory infections (SARI) and among hospitalized patients with laboratory-confirmed influenza. Methods Retrospective analysis of case-based surveillance data collected from sentinel hospitals in Romania during the 2009/2010 and 2010/2011 winter influenza seasons was performed to evaluate risk factors for fatal outcomes using multivariate logistic regression. Results During 2009/2010 and 2010/2011, sentinel hospitals reported 661 SARI patients of which 230 (35%) tested positive for influenza. In the multivariate analyses, infection with influenza A(H1N1)pdm09 was the strongest risk factor for death among hospitalized SARI patients (OR: 66; 95% CI: 33-131). Among patients positive for influenza A(H1N1)pdm09 virus infection (n=148), being pregnant (OR: 71; 95% CI: 16-312), clinically obese (OR: 29;95% CI: 16-312), and having an immunocompromising condition (OR: 37;95% CI: 11-134) were significantly associated with fatal outcomes. Conclusion These findings are consistent with several other investigations of risk factors associated with influenza A(H1N1)pdm09 virus infections. They also support the more recent 2012 recommendations by the WHO Strategic Advisory Group of Experts on Immunization (SAGE) that pregnant women are an important risk group for influenza vaccination. Ongoing sentinel surveillance can be useful tool to monitor risk factors for complications of influenza virus infections during each influenza season, and pandemics as well. C1 [Zolotusca, Laurentiu] Minist Hlth, Bucharest, Romania. [Jorgensen, Pernille; Brown, Caroline S.] WHO Reg Off Europe, Copenhagen, Denmark. [Popovici, Odette; Pistol, Adriana; Popovici, Florin] Natl Inst Publ Hlth, Bucharest, Romania. [Widdowson, Marc-Alain; Cheng, Po-Yung; Gross, Diane; Mott, Joshua A.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Alexandrescu, Viorel; Ivanciuc, Alina] Cantacuzino Inst Res & Dev Microbiol & Immunol, Bucharest, Romania. RP Mott, JA (reprint author), KEMRI Headquarters, Ctr Dis Control & Prevent Kenya, Influenza Program, Mbagathi Rd,Off Mbagathi Way,POB 606, Nairobi 00621, Kenya. EM jmott@ke.cdc.gov NR 14 TC 1 Z9 2 U1 2 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2014 VL 8 IS 1 BP 8 EP 12 DI 10.1111/irv.12209 PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 275VA UT WOS:000328704900002 PM 24251915 ER PT J AU Levy, JW Suntarattiwong, P Simmerman, JM Jarman, RG Johnson, K Olsen, SJ Chotpitayasunondh, T AF Levy, Jens W. Suntarattiwong, Piyarat Simmerman, James M. Jarman, Richard G. Johnson, Kara Olsen, Sonja J. Chotpitayasunondh, Tawee TI Increased hand washing reduces influenza virus surface contamination in Bangkok households, 2009-2010 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Human; influenza; Thailand; transmission ID A VIRUS; TRANSMISSION; SURVIVAL; THAILAND AB Within a hand-washing clinical trial, we evaluated factors associated with fomite contamination in households with an influenza-infected child. Influenza virus RNA contamination was higher in households with low absolute humidity and in control households, suggesting that hand washing reduces surface contamination. C1 [Levy, Jens W.; Simmerman, James M.; Olsen, Sonja J.] Thailand MOPH US CDC Collaborat, Int Emerging Infect Program, Nonthaburi 11000, Thailand. [Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Simmerman, James M.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Jarman, Richard G.] US Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Johnson, Kara] Harvard Univ, Sch Med, Boston, MA USA. RP Levy, JW (reprint author), Thailand MOPH US CDC Collaborat, Minist Publ Hlth, DDC Bldg 7,Soi 4,Tivanon Rd, Nonthaburi 11000, Thailand. EM jenslevy@gmail.com; sco2@cdc.gov FU U.S. CDC [5U51IP000345]; Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System FX This work was supported by funding from the U.S. CDC (cooperative agreement #5U51IP000345).A portion of the laboratory work was funded by the Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System. NR 12 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2014 VL 8 IS 1 BP 13 EP 16 DI 10.1111/irv.12204 PG 4 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 275VA UT WOS:000328704900003 PM 24373290 ER PT J AU Yu, HJ Huang, JG Huai, Y Guan, XH Klena, J Liu, SL Peng, YX Yang, H Luo, J Zheng, JD Chen, MY Peng, ZB Xiang, NJ Huo, XX Xiao, L Jiang, H Chen, H Zhang, YZ Xing, XS Xu, Z Feng, ZJ Zhan, FX Yang, WZ Uyeki, TM Wang, Y Varma, JK AF Yu, Hongjie Huang, Jigui Huai, Yang Guan, Xuhua Klena, John Liu, Shali Peng, Youxing Yang, Hui Luo, Jun Zheng, Jiandong Chen, Maoyi Peng, Zhibin Xiang, Nijuan Huo, Xixiang Xiao, Lin Jiang, Hui Chen, Hui Zhang, Yuzhi Xing, Xuesen Xu, Zhen Feng, Zijian Zhan, Faxian Yang, Weizhong Uyeki, Timothy M. Wang, Yu Varma, Jay K. TI The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010-2012 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE China; disease burden; influenza; seasonality ID CHILDREN YOUNGER; B VIRUS; SEASONAL INFLUENZA; UNITED-STATES; HONG-KONG; DISEASE; POPULATION; PNEUMONIA; MORTALITY; EPIDEMIC AB Background Published data on influenza in severe acute respiratory infection (SARI) patients are limited. We conducted SARI surveillance in central China and estimated hospitalization rates of SARI attributable to influenza by viral type/subtype. Methods Surveillance was conducted at four hospitals in Jingzhou, China from 2010 to 2012. We enrolled hospitalized patients who had temperature 373 degrees C and at least one of: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. A nasopharyngeal swab was collected from each case-patient within 24hours of admission for influenza testing by real-time reverse transcription PCR. Results Of 17172 SARI patients enrolled, 90% were aged <15years. The median duration of hospitalization was 5days. Of 16208 (94%) SARI cases tested, 2057 (13%) had confirmed influenza, including 1427 (69%) aged <5years. Multiple peaks of influenza occurred during summer, winter, and spring months. Influenza was associated with an estimated 115 and 142 SARI hospitalizations per 100000 during 2010-2011 and 2011-2012 [including A(H3N2): 55 and 44 SARI hospitalizations per 100000; pandemic A(H1N1): 33 SARI hospitalizations per 100000 during 2010-2011; influenza B: 26 and 98 hospitalizations per 100000], with the highest rate among children aged 6-11months (3603 and 3805 hospitalizations per 100000 during 2010-2011 and 2011-2012, respectively). Conclusions In central China, influenza A and B caused a substantial number of hospitalizations during multiple periods each year. Our findings strongly suggest that young children should be the highest priority group for annual influenza vaccination in China. C1 [Yu, Hongjie; Zheng, Jiandong; Peng, Zhibin; Jiang, Hui; Xu, Zhen] Chinese Ctr Dis Control & Prevent, Div Infect Dis, Beijing 100050, Peoples R China. [Huang, Jigui; Chen, Maoyi; Xiao, Lin] Jingzhou Ctr Dis Control & Prevent, Jingzhou, Peoples R China. [Huai, Yang; Klena, John; Zhang, Yuzhi; Varma, Jay K.] US Ctr Dis Control & Prevent, China US Collaborat Program Emerging & Reemerging, Beijing, Peoples R China. [Guan, Xuhua; Huo, Xixiang; Chen, Hui; Xing, Xuesen; Zhan, Faxian] Hubei Prov Ctr Dis Control & Prevent, Wuhan, Peoples R China. [Liu, Shali] Jingzhou Cent Hosp, Jingzhou, Peoples R China. [Peng, Youxing] Jingzhou First Peoples Hosp, Jingzhou, Peoples R China. [Yang, Hui] Jingzhou Second Peoples Hosp, Jingzhou, Peoples R China. [Luo, Jun] Jingzhou Maternal & Childrens Hosp, Jingzhou, Peoples R China. [Xiang, Nijuan; Feng, Zijian] Chinese Ctr Dis Control & Prevent, Publ Hlth Emergency Ctr, Beijing, Peoples R China. [Yang, Weizhong; Wang, Yu] Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Varma, Jay K.] Ctr Dis Control & Prevent, Global Dis Detect Program, Div Global Dis Detect & Response, Ctr Global Hlth, Atlanta, GA USA. RP Wang, Y (reprint author), Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China. EM wangyu@chinacdc.cn; jvarma@cdc.gov FU China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases FX This study was supported by grants from the China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases. None of the funders had any role in the study design and the collection, analysis, and interpretation of data, or in the writing of the article and the decision to submit it for publication. NR 42 TC 13 Z9 18 U1 4 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2014 VL 8 IS 1 BP 53 EP 65 DI 10.1111/irv.12205 PG 13 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 275VA UT WOS:000328704900009 PM 24209711 ER PT J AU Shapiro, DJ Hicks, LA Pavia, AT Hersh, AL AF Shapiro, Daniel J. Hicks, Lauri A. Pavia, Andrew T. Hersh, Adam L. TI Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09 SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE antibiotic stewardship; antibiotic resistance; prescribing patterns ID RESPIRATORY-TRACT INFECTIONS; STAPHYLOCOCCUS-AUREUS INFECTIONS; CLINICAL-PRACTICE GUIDELINES; UNITED-STATES; STREPTOCOCCUS-PNEUMONIAE; EMERGENCY-DEPARTMENT; RESISTANCE; SETTINGS; PRESCRIPTIONS; POPULATION AB Objectives: To determine patterns of ambulatory antibiotic prescribing in US adults, including the use of broad-spectrum versus narrow-spectrum agents, to provide a description of the diagnoses for which antibiotics are prescribed and to identify patient and physician factors associated with broad-spectrum antibiotic prescribing. Methods: We used data for patients aged >= 18 years from the National Ambulatory and National Hospital Ambulatory Medical Care Surveys (2007-09). These are nationally representative surveys of patient visits to offices, hospital outpatient departments and emergency departments (EDs) in the USA, collectively referred to as ambulatory visits. We determined the types of antibiotics prescribed, including the use of broad-spectrum versus narrow-spectrum antibiotics, and examined prescribing patterns by diagnoses. We used multivariable logistic regression to identify factors associated with broad-spectrum antibiotic prescribing. Results: Antibiotics were prescribed during 101 million (95% CI:91-111 million) ambulatory visits annually, representing 10% of all visits. Broad-spectrum agents were prescribed during 61% of visits in which antibiotics were prescribed. The most commonly prescribed antibiotics were quinolones (25% of antibiotics), macrolides (20%) and aminopenicillins (12%). Antibiotics were most commonly prescribed for respiratory conditions(41% of antibiotics), skin/mucosal conditions (18%) and urinary tract infections (9%). In multivariable analysis, among patients prescribed antibiotics, broad-spectrum agents were more likely to be prescribed than narrow-spectrum antibiotics for respiratory infections for which antibiotics are rarely indicated (e. g. bronchitis), during visits to EDs and for patients >= 60 years. Conclusions: Broad-spectrum agents constitute the majority of antibiotics in ambulatory care. More than 25% of prescriptions are for conditions for which antibiotics are rarely indicated. Antibiotic stewardship interventions targeting respiratory and non-respiratory conditions are needed in ambulatory care. C1 [Shapiro, Daniel J.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Hicks, Lauri A.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Pavia, Andrew T.; Hersh, Adam L.] Univ Utah, Dept Pediat, Div Pediat Infect Dis, Salt Lake City, UT 84112 USA. RP Hersh, AL (reprint author), Univ Utah, Dept Pediat, Div Pediat Infect Dis, Salt Lake City, UT 84112 USA. EM adam.hersh@hsc.utah.edu FU Centers for Disease Control and Prevention [200-2010-M-36230, IPA 110369] FX This work was supported by contract number 200-2010-M-36230 and IPA 110369 from the Centers for Disease Control and Prevention. NR 34 TC 63 Z9 63 U1 1 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 EI 1460-2091 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD JAN PY 2014 VL 69 IS 1 BP 234 EP 240 DI 10.1093/jac/dkt301 PG 7 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 271XR UT WOS:000328425400034 PM 23887867 ER PT J AU Frasch, HF Dotson, GS Bunge, AL Chen, CP Cherrie, JW Kasting, GB Kissel, JC Sahmel, J Semple, S Wilkinson, S AF Frasch, H. Frederick Dotson, G. Scott Bunge, Annette L. Chen, Chen-Peng Cherrie, John W. Kasting, Gerald B. Kissel, John C. Sahmel, Jennifer Semple, Sean Wilkinson, Simon TI Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE risk assessment; skin absorption; percent absorption; fractional absorption; dermal load; maximum flux; evaporation ID SKIN IN-VITRO; PERCUTANEOUS-ABSORPTION; VOLATILE COMPOUNDS; KINETICS; SOLVENTS AB A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data. C1 [Frasch, H. Frederick] NIOSH, Hlth Effects Lab, Morgantown, WV 26505 USA. [Dotson, G. Scott] NIOSH, Educ & Informat Div, Cincinnati, OH USA. [Bunge, Annette L.] Colorado Sch Mines, Dept Chem & Biol Engn, Golden, CO 80401 USA. [Chen, Chen-Peng] China Med Univ, Coll Publ Hlth, Dept Occupat Safety & Hlth, Taichung, Taiwan. [Cherrie, John W.] Inst Occupat Med, Edinburgh EH8 9SV, Midlothian, Scotland. [Kasting, Gerald B.] Univ Cincinnati, Winkle Coll Pharm, Cincinnati, OH USA. [Kissel, John C.] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Sahmel, Jennifer] ChemRisk, Boulder, CO USA. [Semple, Sean] Univ Aberdeen, Div Appl Hlth Sci, Aberdeen, Scotland. [Wilkinson, Simon] Univ Newcastle, Med Toxicol Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England. RP Frasch, HF (reprint author), NIOSH, Hlth Effects Lab, Morgantown, WV 26505 USA. EM HFrasch@cdc.gov RI Bunge, Annette/A-7995-2012; OI Bunge, Annette/0000-0002-0287-3724; Semple, Sean/0000-0002-0462-7295 NR 37 TC 11 Z9 11 U1 4 U2 24 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2014 VL 24 IS 1 BP 65 EP 73 DI 10.1038/jes.2013.23 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 274KJ UT WOS:000328604900010 PM 23715085 ER PT J AU Suchdev, PS Ruth, LJ Earley, M Macharia, A Williams, TN AF Suchdev, Parminder S. Ruth, Laird J. Earley, Marie Macharia, Alex Williams, Thomas N. TI The burden and consequences of inherited blood disorders among young children in western Kenya SO MATERNAL AND CHILD NUTRITION LA English DT Article DE sickle cell disorders; haemoglobinopathies; thalassaemia; G6PD deficiency; haptoglobins; anaemia ID PLASMODIUM-FALCIPARUM MALARIA; VITAMIN-A-DEFICIENCY; SICKLE-CELL-DISEASE; ALPHA(+)-THALASSEMIA PROTECTS; PRESCHOOL-CHILDREN; IRON-DEFICIENCY; HEMOGLOBIN; ANEMIA; HAPTOGLOBIN; TRAIT AB Although inherited blood disorders are common among children in many parts of Africa, limited data are available about their prevalence or contribution to childhood anaemia. We conducted a cross-sectional survey of 858 children aged 6-35 months who were randomly selected from 60 villages in western Kenya. Haemoglobin (Hb), ferritin, malaria, C-reactive protein (CRP) and retinol binding protein (RBP) were measured from capillary blood. Using polymerase chain reaction (PCR), Hb type, -3.7kb alpha-globin chain deletion, glucose-6-phosphate dehydrogenase (G6PD) genotype and haptoglobin (Hp) genotype were determined. More than 2 out of 3 children had at least one measured blood disorder. Sickle cell trait (HbAS) and disease (HbSS) were found in 17.1% and 1.6% of children, respectively; 38.5% were heterozygotes and 9.6% were homozygotes for (+)-thalassaemia. The Hp 2-2 genotype was found in 20.4% of children, whereas 8.2% of males and 6.8% of children overall had G6PD deficiency. There were no significant differences in the distribution of malaria by the measured blood disorders, except among males with G6PD deficiency who had a lower prevalence of clinical malaria than males of normal G6PD genotype (P=0.005). After excluding children with malaria parasitaemia, inflammation (CRP>5mgL(-1)), iron deficiency (ferritin<12gL(-1)) or vitamin A deficiency (RBP<0.7gL(-1)), the prevalence of anaemia among those without (+)-thalassaemia (43.0%) remained significantly lower than that among children who were either heterozygotes (53.5%) or homozygotes (67.7%, P=0.03). Inherited blood disorders are common among pre-school children in western Kenya and are important contributors to anaemia. C1 [Suchdev, Parminder S.; Ruth, Laird J.] Ctr Dis Control & Prevent, Nutr Branch, Atlanta, GA 30341 USA. [Suchdev, Parminder S.] Emory Univ, Dept Pediat & Global Hlth, Atlanta, GA 30322 USA. [Earley, Marie] CDC, Newborn Screening Qual Assurance Program, Atlanta, GA 30333 USA. [Macharia, Alex; Williams, Thomas N.] KEMRI Ctr Geog Med Res Coast, Kilifi, Kenya. [Williams, Thomas N.] Nuffield Dept Clin Med, Oxford, England. [Williams, Thomas N.] INDEPTH Network, Accra, Ghana. RP Suchdev, PS (reprint author), Ctr Dis Control & Prevent, Nutr Branch, 4770 Buford Highway NE,MS K25, Atlanta, GA 30341 USA. EM psuchdev@cdc.gov OI Suchdev, Parmi/0000-0002-0350-3469 FU US Centers for Disease Control and Prevention, Atlanta; Wellcome Trust, UK [091758] FX This work was supported by the US Centers for Disease Control and Prevention, Atlanta, through a cooperative agreement between CDC and the Kenya Medical Research Institute. TNW is supported by a Senior Fellowship from the Wellcome Trust, UK (091758). NR 36 TC 9 Z9 10 U1 2 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1740-8695 EI 1740-8709 J9 MATERN CHILD NUTR JI Matern. Child Nutr. PD JAN PY 2014 VL 10 IS 1 BP 135 EP 144 DI 10.1111/j.1740-8709.2012.00454.x PG 10 WC Nutrition & Dietetics; Pediatrics SC Nutrition & Dietetics; Pediatrics GA 273ZB UT WOS:000328573700010 PM 22973867 ER PT J AU Fisher, D Li, CM Chiu, MS Themann, CL Petersen, H Jonasson, F Jonsson, PV Sverrisdottir, JE Garcia, M Harris, TB Launer, LJ Eiriksdottir, G Gudnason, V Hoffman, HJ Cotch, MF AF Fisher, Diana Li, Chuan-Ming Chiu, May S. Themann, Christa L. Petersen, Hannes Jonasson, Frithbert Jonsson, Palmi V. Sverrisdottir, Johanna Eyrun Garcia, Melissa Harris, Tamara B. Launer, Lenore J. Eiriksdottir, Gudny Gudnason, Vilmundur Hoffman, Howard J. Cotch, Mary Frances TI Impairments in hearing and vision impact on mortality in older people: the AGES-Reykjavik Study SO AGE AND AGEING LA English DT Article DE AGES-Reykjavik study; hearing; vision; dual sensory impairment; all-cause mortality; cardiovascular disease mortality; older people ID HEALTH INTERVIEW SURVEY; VISUAL IMPAIRMENT; SENSORY IMPAIRMENT; FOLLOW-UP; POPULATION; DISABILITY; CATARACT; PROJECT; ACUITY; ADULTS AB Objective: to examine the relationships between impairments in hearing and vision and mortality from all-causes and cardiovascular disease (CVD) among older people. Design: population-based cohort study. Participants: the study population included 4,926 Icelandic individuals, aged >= 67 years, 43.4% male, who completed vision and hearing examinations between 2002 and 2006 in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-RS) and were followed prospectively for mortality through 2009. Methods: participants were classified as having 'moderate or greater' degree of impairment for vision only (VI), hearing only (HI), and both vision and hearing (dual sensory impairment, DSI). Cox proportional hazard regression, with age as the time scale, was used to calculate hazard ratios (HR) associated with impairment and mortality due to all-causes and specifically CVD after a median follow-up of 5.3 years. Results: the prevalence of HI, VI and DSI were 25.4, 9.2 and 7.0%, respectively. After adjusting for age, significantly (P < 0.01) increased mortality from all causes, and CVD was observed for HI and DSI, especially among men. After further adjustment for established mortality risk factors, people with HI remained at higher risk for CVD mortality [HR: 1.70 (1.27-2.27)], whereas people with DSI remained at higher risk of all-cause mortality [HR: 1.43 (1.11-1.85)] and CVD mortality [HR: 1.78 (1.18-2.69)]. Mortality rates were significantly higher in men with HI and DSI and were elevated, although not significantly, among women with HI. Conclusions: older men with HI or DSI had a greater risk of dying from any cause and particularly cardiovascular causes within a median 5-year follow-up. Women with hearing impairment had a non-significantly elevated risk. Vision impairment alone was not associated with increased mortality. C1 [Fisher, Diana; Cotch, Mary Frances] NEI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA. [Li, Chuan-Ming; Chiu, May S.; Hoffman, Howard J.] NIDCD, Div Sci Programs, Epidemiol & Stat Program, NIH, Bethesda, MD USA. [Themann, Christa L.] NIOSH, Hearing Loss Prevent Team, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Petersen, Hannes; Jonasson, Frithbert; Jonsson, Palmi V.; Gudnason, Vilmundur] Univ Iceland, Fac Med, Reykjavik, Iceland. [Petersen, Hannes] Landspitali Univ Hosp, Dept Otolaryngol Head & Neck Surg, Reykjavik, Iceland. [Jonasson, Frithbert] Landspitali Univ Hosp, Reykjavik, Iceland. [Jonsson, Palmi V.] Landspitali Univ Hosp, Dept Geriatr, IS-101 Reykjavjk, Iceland. [Sverrisdottir, Johanna Eyrun; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland. [Garcia, Melissa; Harris, Tamara B.; Launer, Lenore J.] NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Bethesda, MD 20892 USA. RP Fisher, D (reprint author), NEI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA. EM diana.fisher@nih.gov RI Gudnason, Vilmundur/K-6885-2015; OI Gudnason, Vilmundur/0000-0001-5696-0084; Cotch, Mary Frances/0000-0002-2046-4350 FU National Institutes of Health, National Institute on Aging (NIA) [N01-AG-12100]; NIA [Z01-AG007380]; National Eye Institute (NEI) [ZIAEY000401]; National Institute on Deafness and Other Communication Disorders (NIDCD) Division of Scientific Programs [IAA Y2-DC-1004-02]; Hjartavernd (Icelandic Heart Association); Althingi (Icelandic Parliament) FX This work was supported by the National Institutes of Health, National Institute on Aging (NIA) (contract number N01-AG-12100); the NIA Intramural Research Program (Z01-AG007380); the National Eye Institute (NEI) Intramural Research Program (ZIAEY000401); the National Institute on Deafness and Other Communication Disorders (NIDCD) Division of Scientific Programs (IAA Y2-DC-1004-02); and with funding from Hjartavernd (Icelandic Heart Association) and the Althingi (Icelandic Parliament). NR 30 TC 25 Z9 26 U1 1 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0002-0729 EI 1468-2834 J9 AGE AGEING JI Age Ageing PD JAN PY 2014 VL 43 IS 1 BP 69 EP 76 DI 10.1093/ageing/aft122 PG 8 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 271JZ UT WOS:000328389200014 PM 23996030 ER PT J AU Gingold, JA Simon, AE Schoendorf, KC AF Gingold, Janet A. Simon, Alan E. Schoendorf, Kenneth C. TI Excess Screen Time in US Children: Association With Family Rules and Alternative Activities SO CLINICAL PEDIATRICS LA English DT Article DE children; adolescents; screen time; media use; sedentary behavior; physical activity; National Survey of Children's Health ID PHYSICAL-ACTIVITY; WEIGHT STATUS; MEDIA USE; ADOLESCENT OVERWEIGHT; CHILDHOOD OVERWEIGHT; SEDENTARY BEHAVIORS; TELEVISION USE; DIETARY-INTAKE; MEAL PATTERNS; UNITED-STATES AB We describe the association of screen time in excess of American Academy of Pediatrics recommendations (2 h/d) with family television-use policies and regular nonscreen activities among US school-aged children. Data from the 2007 National Survey of Children's Health were used. The sum of minutes spent on television, videos, video games, and recreational computer use was calculated for children 6 to 17 years old. Bivariate and multivariate logistic regression models were used to calculate relative odds of exceeding American Academy of Pediatrics guidelines and of heavy screen use (>4 h/d) for varying family media-use policies and frequency of alternative activities (physical activity and family meals). In all, 49% of school-aged children had screen time >2 h/d and 16% had screen time >4 h/d. Lower frequency of family meals, presence of TV in the bedroom, absence of rules about TV viewing, and less physical activity were associated with both >2 and >4 hours per day of screen time. C1 [Gingold, Janet A.] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Simon, Alan E.; Schoendorf, Kenneth C.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Schoendorf, Kenneth C.] US PHS, Rockville, MD USA. RP Gingold, JA (reprint author), Childrens Natl Med Ctr, Goldberg Ctr, 111 Michigan Ave NW, Washington, DC 20010 USA. EM jgingold@cnmc.org OI Gingold, Janet/0000-0001-7236-1575 NR 64 TC 9 Z9 9 U1 4 U2 24 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 EI 1938-2707 J9 CLIN PEDIATR JI Clin. Pediatr. PD JAN PY 2014 VL 53 IS 1 BP 41 EP 50 DI 10.1177/0009922813498152 PG 10 WC Pediatrics SC Pediatrics GA 265ZI UT WOS:000327990900008 PM 23922251 ER PT J AU Badaru, A Klingensmith, GJ Dabelea, D Mayer-Davis, EJ Dolan, L Lawrence, JM Marcovina, S Beavers, D Rodriguez, BL Imperatore, G Pihoker, C AF Badaru, Angela Klingensmith, Georgeanna J. Dabelea, Dana Mayer-Davis, Elizabeth J. Dolan, Lawrence Lawrence, Jean M. Marcovina, Santica Beavers, Daniel Rodriguez, Beatriz L. Imperatore, Giuseppina Pihoker, Catherine TI Correlates of Treatment Patterns Among Youth With Type 2 Diabetes SO DIABETES CARE LA English DT Article ID PEDIATRIC-PATIENTS; GLYCEMIC CONTROL; METFORMIN; MONOTHERAPY; CHILDREN; FAILURE; ADOLESCENTS; MELLITUS; SEARCH; TRIAL AB OBJECTIVETo describe treatment regimens in youth with type 2 diabetes and examine associations between regimens, demographic and clinical characteristics, and glycemic control.RESEARCH DESIGN AND METHODSThis report includes 474 youth with a clinical diagnosis of type 2 diabetes who completed a SEARCH for Diabetes in Youth study visit. Diabetes treatment regimen was categorized as lifestyle alone, metformin monotherapy, any oral hypoglycemic agent (OHA) other than metformin or two or more OHAs, insulin monotherapy, and insulin plus any OHA(s). Association of treatment with demographic and clinical characteristics (fasting C-peptide [FCP], diabetes duration, and self-monitoring of blood glucose [SMBG]), and A1C was assessed by (2) and ANOVA. Multiple linear regression models were used to evaluate independent associations of treatment regimens and A1C, adjusting for demographics, diabetes duration, FCP, and SMBG.RESULTSOver 50% of participants reported treatment with metformin alone or lifestyle. Of the autoantibody-negative youth, 40% were on metformin alone, while 33% were on insulin-containing regimens. Participants on metformin alone had a lower A1C (7.0 2.0%, 53 +/- 22 mmol/mol) than those on insulin alone (9.2 +/- 2.7%, 77 +/- 30 mmol/mol) or insulin plus OHA (8.6 +/- 2.6%, 70 +/- 28 mmol/mol) (P < 0.001). These differences remained significant after adjustment (7.5 +/- 0.3%, 58 +/- 3 mmol/mol; 9.1 +/- 0.4%, 76 +/- 4 mmol/mol; and 8.6 +/- 0.4%, 70 +/- 4 mmol/mol) (P < 0.001) and were more striking in those with diabetes for 2 years (7.9 +/- 2.8, 9.9 +/- 2.8, and 9.8 +/- 2.6%). Over one-half of those on insulin-containing therapies still experience treatment failure (A1C 8%, 64 mmol/mol).CONCLUSIONSApproximately half of youth with type 2 diabetes were managed with lifestyle or metformin alone and had better glycemic control than individuals using other therapies. Those with longer diabetes duration in particular commonly experienced treatment failures, and more effective management strategies are needed. C1 [Badaru, Angela; Pihoker, Catherine] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Klingensmith, Georgeanna J.] Univ Colorado, Sch Med, Barbara Davis Ctr, Aurora, CO USA. [Klingensmith, Georgeanna J.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO USA. [Dabelea, Dana] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Dolan, Lawrence] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp, Cincinnati, OH USA. [Lawrence, Jean M.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Marcovina, Santica] Univ Washington, Dept Med, Seattle, WA USA. [Beavers, Daniel] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA. [Rodriguez, Beatriz L.] Univ Hawaii Manoa, John A Burns Sch Med, Honolulu, HI 96822 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. RP Pihoker, C (reprint author), Univ Washington, Dept Pediat, Seattle, WA 98195 USA. EM catherine.pihoker@seattlechildrens.org RI Beavers, Daniel/G-5338-2016 FU Centers for Disease Control and Prevention [00097, DP-05-069, DP-10-001]; NIDDK; Kaiser Permanente Southern California [U48/CCU919219, U01 DP000246, U18DP002714]; University of Colorado Denver [U48/CCU819241-3, U01 DP000247, U18DP000247-06A1]; Kuakini Medical Center [U58CCU919256, U01 DP000245]; Children's Hospital Medical Center (Cincinnati) [U48/CCU519239, U01 DP000248, 1U18DP002709]; University of North Carolina at Chapel Hill [U48/CCU419249, U01 DP000254, U18DP002708-01]; University of Washington School of Medicine [U58/CCU019235-4, U01 DP000244, U18DP002710-01]; Wake Forest University School of Medicine [U48/CCU919219, U01 DP000250, 200-2010-35171]; National Institutes of Health [NIH]/National Center for Research Resources [NCRR] [UL1RR029882]; Children's Hospital and Regional Medical Center [M01RR00037]; Colorado Pediatric General Clinical Research Center [M01 RR00069]; Barbara Davis Center at the University of Colorado Denver [DERC NIH P30 DK57516]; Institutional Clinical and Translational Science Award, NIH/NCRR, at the University of Cincinnati [1UL1RR026314-01] FX SEARCH is funded by the Centers for Disease Control and Prevention (PA numbers 00097, DP-05-069, and DP-10-001) and supported by the NIDDK. Site contract numbers are as follows: Kaiser Permanente Southern California (U48/CCU919219, U01 DP000246, and U18DP002714), University of Colorado Denver (U48/CCU819241-3, U01 DP000247, and U18DP000247-06A1), Kuakini Medical Center (U58CCU919256 and U01 DP000245), Children's Hospital Medical Center (Cincinnati) (U48/CCU519239, U01 DP000248, and 1U18DP002709), University of North Carolina at Chapel Hill (U48/CCU419249, U01 DP000254, and U18DP002708-01), University of Washington School of Medicine (U58/CCU019235-4, U01 DP000244, and U18DP002710-01), and Wake Forest University School of Medicine (U48/CCU919219, U01 DP000250, and 200-2010-35171). The authors acknowledge the involvement of General Clinical Research Centers at the South Carolina Clinical & Translational Research Institute, the Medical University of South Carolina (National Institutes of Health [NIH]/National Center for Research Resources [NCRR] grant no. UL1RR029882), the Children's Hospital and Regional Medical Center (grant no. M01RR00037), the Colorado Pediatric General Clinical Research Center (grant no. M01 RR00069), and the Barbara Davis Center at the University of Colorado Denver (DERC NIH P30 DK57516); the Institutional Clinical and Translational Science Award, NIH/NCRR, at the University of Cincinnati (grant no. 1UL1RR026314-01); and the Children with Medical Handicaps program managed by the Ohio Department of Health. NR 19 TC 5 Z9 5 U1 0 U2 6 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD JAN PY 2014 VL 37 IS 1 BP 64 EP 72 DI 10.2337/dc13-1124 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 275KV UT WOS:000328676000023 PM 24026554 ER PT J AU Chou, CF Sherrod, CE Zhang, XZ Barker, LE Bullard, KM Crews, JE Saaddine, JB AF Chou, Chiu-Fang Sherrod, Cheryl E. Zhang, Xinzhi Barker, Lawrence E. Bullard, Kai McKeever Crews, John E. Saaddine, Jinan B. TI Barriers to Eye Care Among People Aged 40 Years and Older With Diagnosed Diabetes, 2006-2010 SO DIABETES CARE LA English DT Article ID HEALTH-INSURANCE COVERAGE; ANGELES LATINO EYE; AFRICAN-AMERICANS; VISUAL IMPAIRMENT; US ADULTS; VISION; RETINOPATHY; PREVALENCE; GUIDELINES; SERVICES AB OBJECTIVEWe examine barriers to receiving recommended eye care among people aged 40 years with diagnosed diabetes.RESEARCH DESIGN AND METHODSWe analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were asked the main reason why. We categorized the reasons as cost/lack of insurance, no need, no eye doctor/travel/appointment, and other (meaning everything else). We used multinomial logistic regression to control for race/ethnicity, education, income, and other selected covariates.RESULTSAmong adults with diagnosed diabetes, nonadherence to the recommended annual eye examinations was 23.5%. The most commonly reported reasons for not receiving eye care in the preceding 12 months were no need and cost or lack of insurance (39.7 and 32.3%, respectively). Other reasons were no eye doctor, no transportation or could not get appointment (6.4%), and other (21.5%). After controlling for covariates, adults aged 40-64 years were more likely than those aged 65 years (relative risk ratio [RRR] = 2.79; 95% CI 2.01-3.89) and women were more likely than men (RRR = 2.33; 95% CI 1.75-3.14) to report cost or lack of insurance as their main reason. However, people aged 40-64 years were less likely than those aged 65 years to report no need (RRR = 0.51; 95% CI 0.39-0.67) as their main reason.CONCLUSIONSAddressing concerns about cost or lack of insurance for adults under 65 years and no perceived need among those 65 years and older could help improve eye care service utilization among people with diabetes. C1 [Chou, Chiu-Fang; Zhang, Xinzhi; Barker, Lawrence E.; Bullard, Kai McKeever; Crews, John E.; Saaddine, Jinan B.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Sherrod, Cheryl E.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Chou, CF (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM cchou@cdc.gov FU Intramural CDC HHS [CC999999] NR 36 TC 5 Z9 5 U1 0 U2 6 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD JAN PY 2014 VL 37 IS 1 BP 180 EP 188 DI 10.2337/dc13-1507 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 275KV UT WOS:000328676000038 PM 24009300 ER PT J AU de Ravello, L Jones, SE Tulloch, S Taylor, M Doshi, S AF de Ravello, Lori Jones, Sherry Everett Tulloch, Scott Taylor, Melanie Doshi, Sonal TI Substance Use and Sexual Risk Behaviors Among American Indian and Alaska Native High School Students SO JOURNAL OF SCHOOL HEALTH LA English DT Article DE American Indian; Alaska Native; Indians; Native American; North America; sexual behavior; substance use; Youth Risk Behavior Surveillance System ID YOUTH; ADOLESCENTS AB BACKGROUNDWe describe the prevalence of behaviors that put American Indian and Alaska Native (AI/AN) high school students at risk for teen pregnancy and sexually transmitted infections (STIs) and the relationships among race/ethnicity and these behaviors. METHODSWe analyzed merged 2007 and 2009 data from the national Youth Risk Behavior Survey, a biennial, self-administered, school-based survey of US students in grades 9-12 (N=27,912). Prevalence estimates and logistic regression, controlling for sex and grade, were used to examine the associations between race/ethnicity, and substance use, and sexual risk behaviors. RESULTSOf the 26 variables studied, the adjusted odds ratios (AOR) were higher among AI/AN than White students for 18 variables (ranging from 1.4 to 2.3), higher among AI/AN than Black students for 13 variables (ranging from 1.4 to 4.2), and higher among AI/AN than Hispanic students for 5 variables (ranging from 1.4 to 1.5). Odds were lower among AI/AN than Black students for many of the sexual risk-related behaviors. CONCLUSIONSThe data suggest it is necessary to develop targeted, adolescent-specific interventions aimed at reducing behaviors that put AI/AN high school students at risk for teen pregnancy, STI/HIV, and other health conditions. C1 [de Ravello, Lori] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Jones, Sherry Everett] Ctr Dis Control & Prevent, Div Adolescent, Atlanta, GA 30341 USA. [Jones, Sherry Everett] Ctr Dis Control & Prevent, Sch Hlth, Atlanta, GA 30341 USA. [Tulloch, Scott] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Taylor, Melanie] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Doshi, Sonal] Ctr Dis Control & Prevent, Off State Tribal Local & Territorial Support, Atlanta, GA 30341 USA. RP de Ravello, L (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy NE,MS K22, Atlanta, GA 30341 USA. EM leb8@cdc.gov; sce2@cdc.gov; sdt2@cdc.gov; mdt7@cdc.gov; srd5@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 17 Z9 17 U1 2 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4391 EI 1746-1561 J9 J SCHOOL HEALTH JI J. Sch. Health PD JAN PY 2014 VL 84 IS 1 BP 25 EP 32 DI 10.1111/josh.12114 PG 8 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 269CH UT WOS:000328217600004 PM 24320149 ER PT J AU Dooyema, CA Copeland, D Sinclair, JR Shi, JR Wilkins, M Wells, E Collins, J AF Dooyema, Carrie A. Copeland, Daphne Sinclair, Julie R. Shi, Jianrong Wilkins, Melinda Wells, Eden Collins, Jim TI Factors Influencing School Closure and Dismissal Decisions: Influenza A (H1N1), Michigan 2009 SO JOURNAL OF SCHOOL HEALTH LA English DT Article DE influenza; Michigan; non-pharmaceutical interventions; pandemic flu; school closure policy ID TRANSMISSION; COMMUNITY; OUTBREAK; ILLNESS AB BACKGROUNDIn fall 2009, many US communities experienced school closures during the influenza A H1N1 pandemic (pH1N1) and the state of Michigan reported 567 closures. We conducted an investigation in Michigan to describe pH1N1-related school policies, practices, and identify factors related to school closures. METHODSWe distributed an online survey to all Michigan K-12 school principals. Descriptive statistics and chi-square tests summarize school policies, practices, adherence to government guidelines, and differences between schools that closed and those that remained open during the pandemic. RESULTSOf 4441 traditional K-12 Michigan schools, 937 (21%) principals responded to our survey representing approximately 374,000 students and 17,700 teachers. The majority (88%) of schools had influenza preparedness plans and followed government school influenza guidelines. Among respondents, 15% (137/937) of schools closed in fall 2009 with high absenteeism as the primary reason for closure. Schools that closed reported significant illness in their school, had <300 students, and had invested substantial resources preparing and responding to influenza. CONCLUSIONSAdherence to government guidelines for schools appears high in Michigan. Closures occurred in schools that reported significant illness and were likely motivated by excessive absenteeism. Understanding factors related to closures during pH1N1 may inform future pandemic preparedness efforts. C1 [Dooyema, Carrie A.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Copeland, Daphne; Shi, Jianrong] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Sinclair, Julie R.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Philadelphia, PA 19153 USA. [Wilkins, Melinda; Wells, Eden; Collins, Jim] Michigan Dept Community Hlth, Bur Epidemiol, Div Communicable Dis, Lansing, MI 48913 USA. RP Dooyema, CA (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,MS K-26, Chamblee, GA 30341 USA. EM igb7@cdc.gov; dcopeland@cdc.gov; bwg5@cdc.gov; hku3@cdc.gov; wilkinsm@msu.edu; ewells@umich.edu; collinsj12@michigan.gov NR 16 TC 6 Z9 6 U1 4 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4391 EI 1746-1561 J9 J SCHOOL HEALTH JI J. Sch. Health PD JAN PY 2014 VL 84 IS 1 BP 56 EP 62 DI 10.1111/josh.12113 PG 7 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 269CH UT WOS:000328217600008 PM 24320153 ER PT B AU Ballard, DJ Fleming, NS AF Ballard, David J. Fleming, Neil S. BE Ballard, DJ TI Achieving STEEEP Health Care Introduction SO ACHIEVING STEEEP HEALTH CARE LA English DT Editorial Material; Book Chapter C1 [Ballard, David J.] BHCS, Dallas, TX USA. [Ballard, David J.] BHCS Inst Hlth Care Res & Improvement, Dallas, TX USA. [Ballard, David J.] BHCS STEEEP Safe Timely Effect Efficient Equitabl, Dallas, TX USA. [Ballard, David J.] Mayo Clin & Mayo Grad Sch Med, Rochester, MN USA. [Ballard, David J.] Univ Virginia, Sch Med, Charlottesville, VA 22903 USA. [Ballard, David J.] Emory Univ, Sch Med, Med, Atlanta, GA 30322 USA. [Ballard, David J.] Emory Univ, Rollins Sch Publ Hlth, Epidemiol, Atlanta, GA 30322 USA. [Ballard, David J.] Mayo Sect Hlth Serv Evaluat, Rochester, MN USA. [Ballard, David J.] Kerr L White Inst Hlth Serv Res, Rockville, MD USA. [Ballard, David J.] Int Soc Qual Hlth Care, Rockville, MD USA. [Ballard, David J.] AHRQ, Hlth Care Qual & Effectiveness Res Study Sect, Rockville, MD USA. [Ballard, David J.] Univ N Carolina, Chapel Hill, NC 27515 USA. [Fleming, Neil S.] BHCS STEEEP Global Inst, Dallas, TX USA. [Fleming, Neil S.] Ctr Dis Control, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. RP Ballard, DJ (reprint author), AHRQ, Ctr Educ & Res Therapeut Steering Comm, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6538-8; 978-1-4665-6537-1 PY 2014 BP XXIII EP XXIX PG 7 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA BE6PM UT WOS:000374503500003 ER PT B AU Leonard, BM Shutts, C Fleming, NS AF Leonard, Bradley M. Shutts, Christopher Fleming, Neil S. BE Ballard, DJ TI STEEEP Academy SO ACHIEVING STEEEP HEALTH CARE LA English DT Article; Book Chapter ID COMMUNITY HOSPITALS; TRIAL C1 [Leonard, Bradley M.; Fleming, Neil S.] Baylor Hlth Care Syst, STEEEP Global Inst, Dallas, TX USA. [Shutts, Christopher] Baylor Hlth Care Syst, STEEEP Acad, Dallas, TX USA. [Fleming, Neil S.] Ctr Dis Control, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. RP Leonard, BM (reprint author), Baylor Hlth Care Syst, STEEEP Global Inst, Dallas, TX USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6538-8; 978-1-4665-6537-1 PY 2014 BP 51 EP 61 PG 11 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA BE6PM UT WOS:000374503500011 ER PT B AU Fleming, NS Masica, A McCarthy, I AF Fleming, Neil S. Masica, Andrew McCarthy, Ian BE Ballard, DJ TI Evaluation of Clinical, Economic, and Financial Outcomes SO ACHIEVING STEEEP HEALTH CARE LA English DT Article; Book Chapter ID CARE; HEALTH; COSTS C1 [Fleming, Neil S.] BHCS STEEEP Global Inst, Dallas, TX 75246 USA. [Fleming, Neil S.] Ctr Dis Control, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. [Masica, Andrew] Baylor Hlth Care Syst, Clin Innovat, Dallas, TX USA. [McCarthy, Ian] Baylor Hlth Care Syst, Hlth Econ, Dallas, TX USA. RP Fleming, NS (reprint author), BHCS STEEEP Global Inst, Dallas, TX 75246 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6538-8; 978-1-4665-6537-1 PY 2014 BP 83 EP 90 PG 8 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA BE6PM UT WOS:000374503500015 ER PT B AU Fleming, NS Ballard, DJ AF Fleming, Neil S. Ballard, David J. BE Ballard, DJ TI Achieving STEEEP Health Care Conclusion SO ACHIEVING STEEEP HEALTH CARE LA English DT Editorial Material; Book Chapter C1 [Fleming, Neil S.] BHCS STEEEP Global Inst, Dallas, TX 75206 USA. [Fleming, Neil S.] BHCS, Dallas, TX USA. [Fleming, Neil S.] Ctr Dis Control, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. [Ballard, David J.] BHCS, Dallas, TX USA. [Ballard, David J.] BHCS Inst Hlth Care Res & Improvement, Dallas, TX USA. [Ballard, David J.] Global Inst, BHCS STEEEP Safe Timely Effect Efficient Equitabl, Dallas, TX USA. [Ballard, David J.] Mayo Clin & Mayo Grad Sch Med, Rochester, MN USA. [Ballard, David J.] Univ Virginia, Sch Med, Charlottesville, VA 22903 USA. [Ballard, David J.] Emory Univ, Sch Med, Med, Atlanta, GA 30322 USA. [Ballard, David J.] Emory Univ, Rollins Sch Publ Hlth, Epidemiol, Atlanta, GA 30322 USA. [Ballard, David J.] Mayo Sect Hlth Serv Evaluat, Rochester, MN USA. [Ballard, David J.] Kerr L White Inst Hlth Serv Res, Augusta, GA USA. [Ballard, David J.] Int Soc Qual Hlth Care, Melbourne, Vic, Australia. [Ballard, David J.] Agcy Healthcare Res & Qual, Hlth Care Qual & Effectiveness Res Study Sect, Rockville, MD USA. RP Fleming, NS (reprint author), BHCS STEEEP Global Inst, Dallas, TX 75206 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6538-8; 978-1-4665-6537-1 PY 2014 BP 237 EP 242 PG 6 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA BE6PM UT WOS:000374503500032 ER PT J AU Anjum, H Wunderink, RG Balk, R Waterer, GW Grace, B Tulaimat, A Self, WH Grijalva, C Courtney, M Anderson, E Jain, S Bramley, A Fakhran, S AF Anjum, H. Wunderink, R. G. Balk, R. Waterer, G. W. Grace, B. Tulaimat, A. Self, W. H. Grijalva, C. Courtney, M. Anderson, E. Jain, S. Bramley, A. Fakhran, S. TI Outcomes Of Pneumonia Hospitalizations Among Adults With And Without Hyperglycemia And Diabetes Mellitus: Preliminary Results From The Centers For Disease Control And Prevention Etiology Of Pneumonia In The Community (epic) Study SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Anjum, H.; Tulaimat, A.; Fakhran, S.] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA. [Wunderink, R. G.; Grace, B.; Courtney, M.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Balk, R.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Waterer, G. W.] Univ Western Australia, Perth, WA, Australia. [Self, W. H.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Grijalva, C.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Anderson, E.] Emory Univ, Med Ctr, Atlanta, GA 30322 USA. [Jain, S.; Bramley, A.] Ctr Dis Control & Prevent, Nat Ctr Immunizat & Resp Dis, Atlanta, GA USA. EM hanjum77@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A6520 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838206318 ER PT J AU Beavers, SF Mirabelli, MC Chatterjee, A AF Beavers, S. F. Mirabelli, M. C. Chatterjee, A. TI Asthma Control And Exacerbations Among Adults With Diagnoses Of Asthma And COPD SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Beavers, S. F.; Mirabelli, M. C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chatterjee, A.] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA. EM fgx5@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A4596 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204089 ER PT J AU Brust, JCM Shah, NS Mthiyane, T Petersen, L Ning, Y Allana, S Magee, M Master, I Gandhi, NR AF Brust, J. C. M. Shah, N. S. Mthiyane, T. Petersen, L. Ning, Y. Allana, S. Magee, M. Master, I. Gandhi, N. R. TI Novel Grading Scheme To Determine Severity Of Hearing Loss In Patients Treated For Mdr-Tb SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Brust, J. C. M.; Ning, Y.] Montefiore Med Ctr, Bronx, NY 10467 USA. [Brust, J. C. M.; Ning, Y.] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Shah, N. S.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Mthiyane, T.] South African Med Res Council, Durban, South Africa. [Petersen, L.] Univ Cape Town, Cape Town, South Africa. [Allana, S.; Magee, M.; Gandhi, N. R.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Master, I.] King George V King Dinuzulu Hosp Complex, Durban, South Africa. EM jcmbrust@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A2562 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838201720 ER PT J AU Carlson, EK Miller, TL Katz, DJ Vemulapalli, A Fa, A Rohrback, AC Gallups, JS AF Carlson, E. K. Miller, T. L. Katz, D. J. Vemulapalli, A. Fa, A. Rohrback, A. C. Gallups, J. S. TI Practical Economic Evaluation In The Local Setting: A Web-Based Tool To Guide Latent Tuberculosis Infection (ltbi) Screening And Treatment SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Carlson, E. K.; Miller, T. L.; Vemulapalli, A.; Fa, A.; Rohrback, A. C.] Univ North Texas Hlth Sci Ctr, Ft Worth, TX USA. [Katz, D. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gallups, J. S.] Tarrant Cty Publ Hlth, Ft Worth, TX USA. EM erin.carlson@unthsc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3207 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838202483 ER PT J AU Colton, M Hsu, J Chew, G Brugge, D Yip, F Sircar, K Ryan, PH Sandel, M Adamkiewicz, G AF Colton, M. Hsu, J. Chew, G. Brugge, D. Yip, F. Sircar, K. Ryan, P. H. Sandel, M. Adamkiewicz, G. TI Characterizing Asthma Morbidity And The Indoor Environment Of Low-Income, Chinese-American Children In The Green Housing Study SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Colton, M.; Adamkiewicz, G.] Harvard Sch Publ Hlth, Boston, MA USA. [Hsu, J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Chew, G.; Yip, F.; Sircar, K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Brugge, D.] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Ryan, P. H.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Sandel, M.] Boston Univ, Sch Med, Boston, MA 02118 USA. EM mcolton@mail.harvard.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5087 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204571 ER PT J AU Cummings, KJ Virji, MA Park, JY Carey, B Trapnell, BC Healey, T Armstrong, JL Kreiss, K AF Cummings, K. J. Virji, M. A. Park, J. Y. Carey, B. Trapnell, B. C. Healey, T. Armstrong, J. L. Kreiss, K. TI Relationship Between Respiratory Health And Exposure Indices Among Workers At An Indium-Tin Oxide (ito) Production Facility SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Cummings, K. J.; Virji, M. A.; Park, J. Y.; Armstrong, J. L.; Kreiss, K.] NIOSH, CDC, Morgantown, WV USA. [Cummings, K. J.; Carey, B.; Trapnell, B. C.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Healey, T.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. EM cvx5@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3174 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838202451 ER PT J AU Ford, ES AF Ford, E. S. TI Lung Function, Vitamin D Concentrations, And Mortality In United States Adults SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Ford, E. S.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3775 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838203147 ER PT J AU Girard, TD Edwards, KM Self, WH Grijalva, CG Zhu, Y Williams, DJ Jain, S Jackson, JC AF Girard, T. D. Edwards, K. M. Self, W. H. Grijalva, C. G. Zhu, Y. Williams, D. J. Jain, S. Jackson, J. C. TI Long-Term Cognitive Outcomes After Hospitalization For Community-Acquired Pneumonia (cogcap) SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Girard, T. D.; Grijalva, C. G.; Jackson, J. C.] Vanderbilt Univ Sch Med, Nashville, TN USA. [Girard, T. D.; Grijalva, C. G.; Jackson, J. C.] VA Med Ctr, Nashville, TN USA. [Edwards, K. M.; Self, W. H.; Zhu, Y.; Williams, D. J.] Vanderbilt Univ Sch Med, Nashville, TN USA. [Jain, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM timothy.girard@vanderbilt.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A6525 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838206323 ER PT J AU Henneberger, PK Cox-Ganser, J Moore, VC Burge, CB Liang, X Burge, PS AF Henneberger, P. K. Cox-Ganser, J. Moore, V. C. Burge, C. B. Liang, X. Burge, P. S. TI Can Serial Fev1 Identify Work-Related Asthma Cases Missed By Serial Peak Expiratory Flow? SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Henneberger, P. K.; Cox-Ganser, J.; Liang, X.] NIOSH, CDC, Morgantown, WV USA. [Moore, V. C.; Burge, C. B.; Burge, P. S.] Birmingham Heartlands Hosp, Birmingham, W Midlands, England. EM pkh0@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A4594 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204087 ER PT J AU Jayakumar, A Everett, CK Benator, D Davis, JL Alland, D Heilig, C Weiner, M Kerrigan, A Zamudio, C Goldberg, S Whitworth, WC Nahid, P AF Jayakumar, A. Everett, C. K. Benator, D. Davis, J. L. Alland, D. Heilig, C. Weiner, M. Kerrigan, A. Zamudio, C. Goldberg, S. Whitworth, W. C. Nahid, P. TI Quantitative Xpert Mtb/rif To Assess Tuberculosis Treatment Response: Timing To Predict Eight Week Culture Conversion SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Jayakumar, A.; Everett, C. K.; Davis, J. L.; Nahid, P.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Benator, D.] Washington DC VA Med Ctr, Washington, DC USA. [Alland, D.] Rutgers New Jersey Med Sch, Newark, NJ USA. [Heilig, C.; Goldberg, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Weiner, M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Kerrigan, A.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Zamudio, C.] Univ Peruana Cayetano Heredia, Lima, Peru. [Whitworth, W. C.] CDC, Atlanta, GA 30333 USA. EM archana.jayakumar@ucsf.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A2551 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838201710 ER PT J AU Larson, T Antao, VC AF Larson, T. Antao, V. C. TI Localized Pleural Thickening Of Upper Lung Zones SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Larson, T.; Antao, V. C.] ATSDR, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3160 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838202437 ER PT J AU Miller, TL Wilson, FE Pang, W Beavers, S Hoger, S Sharnprapai, S Pagaoa, M Katz, D Weis, SE AF Miller, T. L. Wilson, F. E. Pang, W. Beavers, S. Hoger, S. Sharnprapai, S. Pagaoa, M. Katz, D. Weis, S. E. TI Mortality Hazard And Survival After Tuberculosis Treatment SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Miller, T. L.; Weis, S. E.] Univ North Texas Hlth Sci Ctr, Ft Worth, TX USA. [Wilson, F. E.] Univ Nebraska, Omaha, NE 68182 USA. [Pang, W.] Univ Washington, Seattle, WA 98195 USA. [Beavers, S.; Pagaoa, M.; Katz, D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hoger, S.] Tarleton State Univ, Ft Worth, TX USA. [Sharnprapai, S.] Massachusetts Dept Publ Hlth, Jamaica, NJ USA. EM thaddeus.miller@unthsc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5771 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838205391 ER PT J AU Mirabelli, MC Beavers, SF Chatterjee, AB AF Mirabelli, M. C. Beavers, S. F. Chatterjee, A. B. TI Active Asthma, Smoking Status, And The Prevalence Of COPD Among Adults With A History Of Asthma SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Mirabelli, M. C.; Beavers, S. F.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Chatterjee, A. B.] Wake Forest Sch Med, Winston Salem, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5934 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838205554 ER PT J AU Mirabelli, MC Beavers, SF Flanders, WD Chatterjee, AB AF Mirabelli, M. C. Beavers, S. F. Flanders, W. D. Chatterjee, A. B. TI Five-Year Reliability Of Self-Reported Asthma History Among Adult Study Participants SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Mirabelli, M. C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Flanders, W. D.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Chatterjee, A. B.] Wake Forest Sch Med, Winston Salem, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A2303 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838201462 ER PT J AU Peisl, A Doney, B Hoffman, EA Graziani, M Kullman, G Kaufman, JD Burchfiel, C Donohue, KM Stukovsky, KH Fujishiro, K Barr, RG AF Peisl, A. Doney, B. Hoffman, E. A. Graziani, M. Kullman, G. Kaufman, J. D. Burchfiel, C. Donohue, K. M. Stukovsky, K. Hinckley Fujishiro, K. Barr, R. G. TI Occupational Risk Factors For Percent Emphysema On Computed Tomography In The Multi-Ethnic Study Of Atherosclerosis SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Peisl, A.; Donohue, K. M.; Barr, R. G.] Columbia Univ, New York, NY USA. [Doney, B.; Graziani, M.; Burchfiel, C.] NIOSH, Morgantown, WV USA. [Hoffman, E. A.] Univ Iowa, Iowa City, IA USA. [Kullman, G.] IH Consulting LLC, Morgantown, WV USA. [Kaufman, J. D.; Stukovsky, K. Hinckley] Univ Washington, Seattle, WA 98195 USA. [Fujishiro, K.] NIOSH, Cincinnati, OH 45226 USA. EM acp2173@columbia.edu NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5099 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204583 ER PT J AU Pinheiro, GA Henley, S Larson, T Antao, VC AF Pinheiro, G. A. Henley, S. Larson, T. Antao, V. C. TI Association Between Asbestos Consumption And Pleural Mesothelioma Incidence In The Usa SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Pinheiro, G. A.; Larson, T.; Antao, V. C.] Agcy Tox Subst & Dis Registry, Atlanta, GA USA. [Henley, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM ghp6@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5770 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838205390 ER PT J AU Pleasants, RA Heidari, K Wheaton, A Ohar, JA Strange, CB Mannino, DM Croft, J Liao, W Kraft, M AF Pleasants, R. A. Heidari, K. Wheaton, A. Ohar, J. A. Strange, C. B. Mannino, D. M. Croft, J. Liao, W. Kraft, M. TI Adults At Risk For COPD - Use Of The Behavioral Risk Factor Surveillance System SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Pleasants, R. A.; Kraft, M.] Duke Univ, Med Ctr, Durham, NC USA. [Heidari, K.] South Carolina Dept Environm Hlth Control, Columbia, SC USA. [Wheaton, A.; Croft, J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ohar, J. A.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA. [Strange, C. B.] Med Univ South Carolina, Charleston, SC USA. [Mannino, D. M.] Univ Kentucky, Lexington, KY USA. [Liao, W.] NC COPD Taskforce, Cary, NC USA. EM roy.pleasants@duke.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5957 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838205577 ER PT J AU Pleasants, RA Heidari, K Wheaton, A Ohar, JA Strange, CB Mannino, DM Croft, J Liao, W Kraft, M AF Pleasants, R. A. Heidari, K. Wheaton, A. Ohar, J. A. Strange, C. B. Mannino, D. M. Croft, J. Liao, W. Kraft, M. TI Use Of The Behavioral Risk Factor Surveillance System To Describe Comorbidities And Health Impairment In Adults At High-Risk For COPD SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Pleasants, R. A.] Duke Univ, Med Ctr, Durham, NC USA. [Heidari, K.] South Carolina Dept Environm Hlth Control, Columbia, SC USA. [Wheaton, A.; Croft, J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ohar, J. A.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA. [Strange, C. B.] Med Univ South Carolina, Charleston, SC USA. [Mannino, D. M.] Univ Kentucky, Coll Publ Hlth, Lexington, KY USA. [Liao, W.] NC COPD Taskforce, Cary, NC USA. [Kraft, M.] Duke Univ, Med Ctr, Dept Pulm & Crit Care Med, Durham, NC 27706 USA. EM roy.pleasants@duke.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5817 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838205437 ER PT J AU Reddy, D Winter, M Moro, R Feng, PJ Goldberg, S Saukkonen, JJ AF Reddy, D. Winter, M. Moro, R. Feng, P. -J. Goldberg, S. Saukkonen, J. J. TI Time-Based Analysis For Alanine Transaminase Monitoring To Detect Hepatotoxicity During Tuberculosis Treatment SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Reddy, D.; Saukkonen, J. J.] Boston Univ, Boston, MA 02215 USA. [Winter, M.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Moro, R.; Feng, P. -J.; Goldberg, S.] CDC, Atlanta, GA 30333 USA. EM divya.reddy@bmc.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3202 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838202478 ER PT J AU Soyseth, V Bakke, B Henneberger, PK Kongerud, J AF Soyseth, V. Bakke, B. Henneberger, P. K. Kongerud, J. TI Accelerated Annual Decline In Fev1 Among Norwegian Aluminum Workers SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Soyseth, V.] Akershus Univ Hosp, Lorenskog, Norway. [Soyseth, V.; Bakke, B.] Natl Inst Occupat Hlth, Oslo, Norway. [Henneberger, P. K.] NIOSH, CDC, Morgantown, WV USA. [Kongerud, J.] Univ Oslo, Oslo, Norway. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A5100 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204584 ER PT J AU Tam, EK Sircar, K Miike, R Yip, F Divinksi, T AF Tam, E. K. Sircar, K. Miike, R. Yip, F. Divinksi, T. TI Is Vog Exposure Associated With Airway Obstruction In Hawaii Island Schoolchildren? SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Tam, E. K.; Miike, R.; Divinksi, T.] Univ Hawaii, Honolulu, HI 96822 USA. [Sircar, K.; Yip, F.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM tameliza@hawaii.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A2312 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838201471 ER PT J AU Volkmann, T Oeltmann, J Moonan, P Miramontes, R AF Volkmann, T. Oeltmann, J. Moonan, P. Miramontes, R. TI Tuberculosis And Excess Alcohol Use In The United States, 1997-2012 SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Volkmann, T.; Oeltmann, J.; Moonan, P.; Miramontes, R.] CDC, Atlanta, GA 30333 USA. EM xdh4@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A3210 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838202486 ER PT J AU Waterer, GW Self, WH Girard, TD Trabue, C McNabb, P Courtney, DM Anderson, E Fakhran, S Balk, R Grijalva, CG Bramley, A Jain, S AF Waterer, G. W. Self, W. H. Girard, T. D. Trabue, C. McNabb, P. Courtney, D. M. Anderson, E. Fakhran, S. Balk, R. Grijalva, C. G. Bramley, A. Jain, S. TI Analysis Of Adult Inpatient Deaths In The Cdc-Etiology Of Pneumonia In The Community (epic) Study: Implications For Community-Acquired Pneumonia (cap) Quality Of Care (qoc) Metrics SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Waterer, G. W.] Univ Western Australia, Perth, WA, Australia. [Self, W. H.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Girard, T. D.; Grijalva, C. G.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Trabue, C.; McNabb, P.] Nashville Baptist Hosp, Nashville, TN USA. [Courtney, D. M.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Anderson, E.] Emory Univ, Atlanta, GA 30322 USA. [Fakhran, S.] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA. [Balk, R.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Bramley, A.; Jain, S.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A6518 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838206316 ER PT J AU White, GE Mazurek, JM Storey, E AF White, G. E. Mazurek, J. M. Storey, E. TI The Proportion Of Employed Adults With Asthma Who Have Frequent Workplace Exposures SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [White, G. E.; Mazurek, J. M.; Storey, E.] NIOSH, CDC, Morgantown, WV USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A6494 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838206293 ER PT J AU Wunderink, RG Self, WH Waterer, GW Anderson, E Balk, R Fakhran, S Courtney, D Qi, C Williams, D Zhu, Y Hicks, L Whitney, CG Moore, MR Carvalho, MDG Bramley, A Jain, S Edwards, K Grijalva, CG AF Wunderink, R. G. Self, W. H. Waterer, G. W. Anderson, E. Balk, R. Fakhran, S. Courtney, D. Qi, C. Williams, D. Zhu, Y. Hicks, L. Whitney, C. G. Moore, M. R. Carvalho, M. D. G. Bramley, A. Jain, S. Edwards, K. Grijalva, C. G. TI Occult Pneumococcal Community-Acquired Pneumonia (cap) In The Cdc Etiology Of Pneumonia In The Community (epic) Study Detected By Serotype-Specific Urinary Antigen Detection (ssuad) SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Wunderink, R. G.; Courtney, D.; Qi, C.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Self, W. H.; Grijalva, C. G.] Vanderbilt Univ, Nashville, TN 37235 USA. [Waterer, G. W.] Univ Western Australia, Perth, WA, Australia. [Anderson, E.] Emory Univ, Atlanta, GA 30322 USA. [Balk, R.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Fakhran, S.] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA. [Williams, D.; Zhu, Y.; Edwards, K.] Vanderbilt Univ, Nashville, IL USA. [Hicks, L.; Whitney, C. G.; Moore, M. R.; Carvalho, M. D. G.; Bramley, A.; Jain, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2014 VL 189 MA A4639 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TF UT WOS:000209838204131 ER PT J AU Cummings, KJ McCague, AB Kreiss, K AF Cummings, Kristin J. McCague, Anna-Binney Kreiss, Kathleen TI Nonmalignant Respiratory Disease Mortality in Styrene-Exposed Workers SO EPIDEMIOLOGY LA English DT Letter ID REINFORCED-PLASTICS; INDUSTRY C1 [Cummings, Kristin J.; McCague, Anna-Binney; Kreiss, Kathleen] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Cummings, KJ (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. EM kcummings@cdc.gov FU Intramural NIH HHS NR 5 TC 4 Z9 4 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 EI 1531-5487 J9 EPIDEMIOLOGY JI Epidemiology PD JAN PY 2014 VL 25 IS 1 BP 160 EP 161 DI 10.1097/EDE.0b013e3182a70b0f PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 268XW UT WOS:000328205200032 PM 24296936 ER PT B AU Astrovskaya, I Mancuso, N Tork, B Mangul, S Artyomenko, A Skums, P Ganova-Raeva, L Mandoiu, I Zelikovsky, A AF Astrovskaya, Irina Mancuso, Nicholas Tork, Bassam Mangul, Serghei Artyomenko, Alex Skums, Pavel Ganova-Raeva, Lilia Mandoiu, Ion Zelikovsky, Alex BE Poptsova, MS TI Inferring Viral Quasispecies Spectra from Shotgun and Amplicon Next-generation Sequencing Reads SO GENOME ANALYSIS: CURRENT PROCEDURES AND APPLICATIONS LA English DT Article; Book Chapter ID ERROR-CORRECTION; RNA VIRUSES; HIGH-THROUGHPUT; IN-VIVO; RECONSTRUCTION; TECHNOLOGIES; MUTATIONS; VACCINE; DESIGN; HIV-1 AB Many clinically relevant viruses, including hepatitis C virus (HCV) and human immunodeficiency virus (HIV), exhibit high genomic diversity within infected hosts which may explain the failure of vaccines and resistance to existing antiviral therapies. Characterizing the viral population infecting a host requires reconstructing all coexisting (related, but non-identical) viral variants, referred to as quasispecies, and inferring their relative abundances. Next-generation sequencing is a promising approach for characterizing viral diversity due to its ability to generate a large number of reads at a low cost. However, standard assembly software was originally designed for a single genome assembly and cannot be used to assemble multiple closely related quasispecies sequences and estimate their abundances. In this chapter, we focus on the problem of reconstructing viral quasispecies populations from next-generation sequencing reads produced by two most commonly used strategies: the shotgun sequencing and the sequencing of partially overlapping PCR amplicons. We discuss computational challenges associated with each strategy and review existing approaches to quasispecies reconstruction with focus on two state-of-the-art software tools - Viral Spectrum Assembler (ViSpA), designed for the shotgun reads, and Viral Assembler (VirA), which handles the amplicon reads. Both tools have been tested on simulated and real read data from HCV, HIV (ViSpA) and HBV (VirA) quasispecies, and shown to compare favourably with other existing methods. C1 [Astrovskaya, Irina] Univ Maryland, Ctr Bioinformat & Computat, College Pk, MD 20742 USA. [Mancuso, Nicholas; Tork, Bassam; Artyomenko, Alex] Georgia State Univ, Dept Comp Sci, Atlanta, GA 30303 USA. [Mangul, Serghei; Zelikovsky, Alex] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA. [Skums, Pavel; Ganova-Raeva, Lilia] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Mandoiu, Ion] Univ Connecticut, Dept Comp Sci & Engn, Storrs, CT USA. RP Astrovskaya, I (reprint author), Univ Maryland, Ctr Bioinformat & Computat, College Pk, MD 20742 USA. EM iastrovskaya@gmail.com; nick.mancuso@gmail.com; basamt@gmail.com; serghei@cs.ucla.edu; artyomenkoav@gmail.com; skumsp@gmail.com; lkg7@cdc.gov; ion@engr.uconn.edu; alexz@cs.gsu.edu OI Zelikovsky, Alexander/0000-0003-4424-4691 NR 68 TC 0 Z9 0 U1 0 U2 0 PU CAISTER ACADEMIC PRESS PI WYMONDHAM PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND BN 978-1-908230-68-3; 978-1-908230-29-4 PY 2014 BP 231 EP 262 PG 32 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA BF7MU UT WOS:000384249900013 ER PT J AU Amek, NO Odhiambo, FO Khagayi, S Moige, H Orwa, G Hamel, MJ Van Eijk, A Vulule, J Slutsker, L Laserson, KF AF Amek, Nyaguara O. Odhiambo, Frank O. Khagayi, Sammy Moige, Hellen Orwa, Gordon Hamel, Mary J. Van Eijk, Annemieke Vulule, John Slutsker, Laurence Laserson, Kayla F. TI Childhood cause-specific mortality in rural Western Kenya: application of the InterVA-4 model SO GLOBAL HEALTH ACTION LA English DT Article DE under-5; verbal autopsy; InterVA; health and demographic surveillance AB Background: Assessing the progress in achieving the United Nation's Millennium Development Goals in terms of population health requires consistent and reliable information on cause-specific mortality, which is often rare in resource-constrained countries. Health and demographic surveillance systems (HDSS) have largely used medical personnel to review and assign likely causes of death based on the information gathered from standardized verbal autopsy (VA) forms. However, this approach is expensive and time consuming, and it may lead to biased results based on the knowledge and experience of individual clinicians. We assessed the cause-specific mortality for children under 5 years old (under-5 deaths) in Siaya County, obtained from a computer-based probabilistic model (InterVA-4). Design: Successfully completed VA interviews for under-5 deaths conducted between January 2003 and December 2010 in the Kenya Medical Research Institute/US Centers for Disease Control and Prevention HDSS were extracted from the VA database and processed using the InterVA-4 (version 4.02) model for interpretation. Cause-specific mortality fractions were then generated from the causes of death produced by the model. Results: A total of 84.33% (6,621) childhood deaths had completed VA data during the study period. Children aged 1-4 years constituted 48.53% of all cases, and 42.50% were from infants. A single cause of death was assigned to 89.18% (5,940) of cases, 8.35% (556) of cases were assigned two causes, and 2.10% (140) were assigned 'indeterminate' as cause of death by the InterVA-4 model. Overall, malaria (28.20%) was the leading cause of death, followed by acute respiratory infection including pneumonia (25.10%), in under-5 children over the study period. But in the first 5 years of the study period, acute respiratory infection including pneumonia was the main cause of death, followed by malaria. Similar trends were also reported in infants (29 days-11 months) and children aged 1-4 years. Conclusions: Under-5 cause-specific mortality obtained using the InterVA-4 model is consistent with existing knowledge on the burden of childhood diseases in rural western Kenya. C1 [Amek, Nyaguara O.; Odhiambo, Frank O.; Khagayi, Sammy; Moige, Hellen; Orwa, Gordon; Van Eijk, Annemieke; Vulule, John; Laserson, Kayla F.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Hamel, Mary J.; Slutsker, Laurence; Laserson, Kayla F.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. RP Amek, NO (reprint author), Kenya Govt Med Res Ctr, POB 1578, Kisumu, Kenya. EM namek@kemricdc.org FU Sida (Research Cooperation); Wellcome Trust; William & Flora Hewlett Foundation FX We thank the study area community for providing this information, and all HDSS staffs for assisting in collecting and processing it. KEMRI/CDC HDSS is a member of the INDEPTH Network. This article is published with permission from the Director of KEMRI. We are grateful to the INDEPTH Secretariat for organising and funding a series of data analysis and scientific writing workshops in Ghana, Thailand, Belgium and UK through core support grants from Sida (Research Cooperation), the Wellcome Trust and the William & Flora Hewlett Foundation. NR 36 TC 5 Z9 5 U1 0 U2 0 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1654-9880 J9 GLOBAL HEALTH ACTION JI Glob. Health Action PY 2014 VL 7 AR 25581 DI 10.3402/gha.v7.25581 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V44GA UT WOS:000209736300001 PM 25377340 ER PT J AU Xu, XYS Dong, RG Welcome, DE Warren, C McDowell, TW AF Xu, Xueyan S. Dong, Ren G. Welcome, Daniel E. Warren, Christopher McDowell, Thomas W. TI An examination of the handheld adapter approach for measuring hand-transmitted vibration exposure SO MEASUREMENT LA English DT Article DE Hand-arm vibration; Hand-transmitted vibration; Vibration measurement; Vibration dosimeter; Handheld adapter ID GLOVES; TOOLS; TRANSMISSIBILITY; WRIST; TIME; PALM AB The use of a handheld adapter equipped with a tri-axial accelerometer is the most convenient and efficient approach for measuring vibration exposure at the hand-tool interface, especially when the adapter is incorporated into a miniature handheld or wrist-strapped dosimeter. To help optimize the adapter approach, the specific aims of this study are to identify and understand the major sources and mechanisms of measurement errors and uncertainties associated with using these adapters, and to explore their improvements. Five representative adapter models were selected and used in the experiment. Five human subjects served as operators in the experiment on a hand-arm vibration test system. The results of this study confirm that many of the handheld adapters can produce substantial overestimations of vibration exposure, and measurement errors can significantly vary with tool, adapter model, mounting position, mounting orientation, and subject. Major problems with this approach include unavoidable influence of the hand dynamic motion on the adapter, unstable attachment, insufficient attachment contact force, and inappropriate adapter structure. However, the results of this study also suggest that measurement errors can be substantially reduced if the design and use of an adapter can be systematically optimized toward minimizing the combined effects of the identified factors. Some potential methods for improving the design and use of the adapters are also proposed and discussed. Published by Elsevier Ltd. C1 [Xu, Xueyan S.; Dong, Ren G.; Welcome, Daniel E.; Warren, Christopher; McDowell, Thomas W.] NIOSH, Engn & Control Technol Branch, Morgantown, WV 26505 USA. RP Dong, RG (reprint author), NIOSH, ECTB, HELD, CDC, 1095 Willowdale Rd,MS L-2027, Morgantown, WV 26505 USA. EM RDong@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 FU Intramural CDC HHS [CC999999] NR 39 TC 2 Z9 2 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-2241 EI 1873-412X J9 MEASUREMENT JI Measurement PD JAN PY 2014 VL 47 BP 64 EP 77 DI 10.1016/j.measurement.2013.08.037 PG 14 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 268UR UT WOS:000328196600010 PM 26744580 ER PT B AU Zheng, ZC Wei, Z Bennett, JS AF Zheng, Z. C. Wei, Z. Bennett, J. S. GP ASME TI INVESTIGATION OF EXHAUST CONDITIONS ON INFLUENCING CONTAMINANT TRANSPORT FOR INDOOR ENVIRONMENTS SO PROCEEDINGS OF THE ASME FLUIDS ENGINEERING DIVISION SUMMER MEETING - 2014, VOL 1A: SYMPOSIA LA English DT Proceedings Paper CT 4th ASME Joint US-European Fluids Engineering Diviison Summer Meeting CY AUG 03-07, 2014 CL Chicago, IL SP ASME, Fluids Engn Div ID PARTICLE DEPOSITION; CHAMBER; FLOWS; MODEL; ROOM AB Indoor air quality is an important issue involved in a wide variety of industrial applications. In an indoor environment, different types of contaminants exist and have an inevitable potential to cause health problems for human beings and animals. In this study, the focus is on the contaminant contained in painting materials. While painting materials being sprayed to solid surfaces, pollutant plumes are formed near the painting area, which may enclose the body parts of the sprayers. Severe health problems are, possible to occur if a significant amount of painting materials settles on the face of workers. By applying exhaust conditions (i.e. exhaust fan with outlet velocity), the flow convection in the room can be enhanced, which may alleviate the contaminant level on the human body. In such a case, the choice of exhaust condition becomes crucial. With the aid of computational fluid dynamics, an optimal exhaust condition can be determined. To simulate this kind of fluid/solid-particle multiphase flow, the current study employs a pure Eulerian or Euler-Euler type model. In the Euler-Euler approach, the properties of the contaminant particles are assumed to be continuous as those of fluids and all phases are computed in the Eulerian framework. Since the exhaust speed is moderately low and fully turbulent flow is not guaranteed in the room, the RNG k-e model is used as a low Reynolds number turbulent model. The current paper firstly investigated the scenario of sprayer self-contamination. Then, inter-contaminations among different workers will be studied. C1 [Zheng, Z. C.; Wei, Z.] Univ Kansas, Lawrence, KS 66045 USA. [Bennett, J. S.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Zheng, ZC (reprint author), Univ Kansas, Lawrence, KS 66045 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4621-6 PY 2014 AR V01AT03A023 PG 8 WC Engineering, Mechanical SC Engineering GA BF0WK UT WOS:000379634600038 ER PT S AU Cauda, E Joy, G Miller, A Mischler, S AF Cauda, Emanuele Joy, Gerald Miller, Arthur Mischler, Steven BE Harper, M Lee, T TI Analysis of the Silica Percent in Airborne Respirable Mine Dust Samples From US Operations SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE mining; dust; silica content ID COAL-DUST AB Exposure to crystalline silica in mining can lead to silicosis, a potentially fatal lung disease, and it may be contributing to the increase of coal workers' pneumoconiosis (CWP) seen in Appalachian miners. Exposure to silica in mines is controlled indirectly by reducing the respirable dust exposure limit through a formula that employs the % of silica in the dust. To reduce this exposure, control technologies and specific monitoring techniques need to be developed and implemented and the knowledge of the % of silica in mine dusts can help this process. This manuscript analyzes the % of silica in dust samples for the U.S. mining industry collected from 1997 to 2011. In the metal/nonmetal (M/NM) industry, metal and sand and gravel mines showed the highest silica % (8.2 %, 9.8 %) along with the highest variability. The silica % was found to be lower for samples collected in underground by comparison to surface and mill. In the coal industry, the samples collected in surface locations showed high silica % in the dust. For both the coal and M/NM industries, the % of silica and the respirable dust concentration were inversely related-i.e., the lower the dust concentration, the higher and more variable silica percentages were observed. The respirable dust limit formula suggests the first explanation: a mine with a high silica % in the dust is required to keep the dust concentration low under the reduced standard. Additional explanations are also proposed: the variability of the % of silica in the dust, the selective efficiency of control technologies, and different transport properties for dust with variable silica content. The findings improve the understanding of exposure to silica in mining environments and the data presented will be helpful in developing monitoring strategies for the measurement of silica and for the design of control technologies. C1 [Cauda, Emanuele; Joy, Gerald; Miller, Arthur; Mischler, Steven] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Publ Hlth Serv, Natl Inst Occupat Safety & Hlth,Off Min Safety &, Pittsburgh, PA 15217 USA. RP Cauda, E (reprint author), Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Publ Hlth Serv, Natl Inst Occupat Safety & Hlth,Off Min Safety &, Pittsburgh, PA 15217 USA. NR 20 TC 0 Z9 0 U1 2 U2 2 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 12 EP 27 DI 10.1520/STP156520120210 PG 16 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000002 ER PT S AU Stacey, P Mecchia, M Verpaele, S Pretorius, C Key-Schwartz, R Mattenklott, M Eypert-Blaison, C Thorpe, A Roberts, P Frost, G AF Stacey, Peter Mecchia, Marco Verpaele, Steven Pretorius, Cecilia Key-Schwartz, Rosa Mattenklott, Markus Eypert-Blaison, Celine Thorpe, Andrew Roberts, Paul Frost, Gillian BE Harper, M Lee, T TI Differences Between Samplers for Respirable Dust and the Analysis of Quartz-An International Study SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE respirable; dust; sampler; quartz; XRD analysis; performance; Arizona Road Dust; silica; X-ray diffraction; sampler uncertainty ID FLOW RATE SAMPLERS; X-RAY-DIFFRACTION; ALPHA-QUARTZ; PERFORMANCE; CYCLONE AB Members of an international standards working group for silica measurement (ISO/TC146/SC2/WG7 Silica) collaborated to assess the differences between sample preparation approaches for the analysis of respirable crystalline silica (RCS) by X-ray diffraction (XRD). They also assessed the relative collection efficiencies of 13 respirable samplers. The evaluation involved nine laboratories from eight countries. Samplers were exposed to airborne concentrations of ultrafine and medium Arizona road dust (ARD) in a calm air chamber. Each participating laboratory analysed samples following their own method and the Health and Safety Laboratory (HSL) retained a third of the samples for verification. All methods and analytical approaches applied in this study obtained comparable results (most were within 12 %). An exception was a method used with the CIP10 R sampler, which reported lower values. Correcting for the crystallinity of the calibration quartz dust using a verified value tested against a certified reference material has one of the largest impacts on the comparability of results. When following good analytical practice, the main factors affecting the comparability of results for RCS are significant differences in sampler efficiencies. In particular, the conductive sampler from SKC obtained a higher concentration of respirable dust (1.3-1.4x) when compared with the average air concentration. The Dorr Oliver, SKC aluminium, CIP10 R, and IOM head (with polyurethane foam separator) samplers all reported lower respirable dust air concentrations than average with the ultrafine ARD. Their lower collection efficiency compared with other samplers is explainable from published sampler information. The Dorr Oliver sampler also had a tendency to collect a lower proportion of RCS in the respirable dust than others. The working group propose that more stringent particle size selection and mass collection criteria are used to improve consistency and crossutilisation of exposure data between countries. C1 [Stacey, Peter; Thorpe, Andrew; Roberts, Paul; Frost, Gillian] HSL, Harpur Hill, Buxton SK17 9JN, England. [Mecchia, Marco] INAIL, Italian Workers Compensat Author, Risk Assessment & Prevent Tech Advisory Off, I-00143 Rome, Italy. [Verpaele, Steven] Adhesia, B-1000 Brussels, Belgium. [Pretorius, Cecilia] CSIR Ctr Min Innovat, Human Factors Res Grp, Pretoria, South Africa. [Key-Schwartz, Rosa] NIOSH, Cincinnati, OH 45226 USA. [Mattenklott, Markus] IFA Inst Arbeitsschutz Deutsch Gesetzlichen Unfal, D-53757 St Augustin, Germany. [Eypert-Blaison, Celine] INRS Inst Natl Rech & Secur, Ctr Lorraine, Dept Metrol Polluants, Lab Anal Inorgan & Caracterisat Aerosols, F-54519 Vandoeuvre Les Nancy, France. RP Stacey, P (reprint author), HSL, Harpur Hill, Buxton SK17 9JN, England. EM peter.stacey@hsl.gov.uk NR 31 TC 0 Z9 0 U1 1 U2 1 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 73 EP 102 DI 10.1520/STP156520120188 PG 30 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000006 ER PT S AU Coggins, MA Healy, CB Lee, T Harper, M AF Coggins, Marie A. Healy, Catherine B. Lee, Taekhee Harper, Martin BE Harper, M Lee, T TI Performance of High-Flow-Rate Samplers for Respirable Crystalline Silica Measurement Under Field Conditions: Preliminary Study SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE Respirable crystalline silica; Occupational exposure assessment; Stone masonry ID DUST; QUARTZ; EXPOSURE AB Restoration stone work regularly involves work with high-silica-content materials (e.g., sandstone), but low-silica-content materials (<2 % quartz) such as limestone and lime mortar are also used. A combination of short sample duration and low silica content makes the quantification of worker exposure to respirable crystalline silica (RCS) difficult. This problem will be further compounded by the introduction of lower occupational exposure standards for RCS. The objective of this work was to determine whether higher-flow samplers might be an effective tool in characterizing lower RCS concentrations. A short study was performed to evaluate the performance of three high-flow samplers (FSP10, CIP10-R, and GK2.69) using side-by-side sampling with low-flow samplers (SIMPEDS and 10-mm nylon cyclones) for RCS exposure measurement at a restoration stonemasonry field site. A total of 19 side-by-side sample replicates for each high-flow and low-flow sampler pair were collected from work tasks involving limestone and sandstone. RESULTS. Most of the RCS (quartz) masses collected with the high-flow-rate samplers were above the limit of detection (62 % to 84 %) relative to the low-flow-rate samplers (58 % to 78 %). The average of the respirable mass concentration ratios for CIP10-R/SIMPEDS, GK2.69/10-mm nylon, FSP10/SIMPEDS, and FSP10/10-mm nylon pairs and the range of the quartz concentration ratios for the CIP10-R/SIMPEDS, CIP10-R/10-mm nylon, GK2.69/10-mm nylon, FSP10/SIMPEDS, and FSP10/10-mm nylon pairs included unity with an average close to unity, indicating no likely difference between the reported values for each sampler. Workers reported problems related to the weight of the sampling pumps for the high-flow-rate samplers. Respirable mass concentration data suggest that the high-flow-rate samplers evaluated would be appropriate for sampling respirable dust concentrations during restoration stone work. Results from the comparison of average quartz concentration ratios between high- and low-flow samplers suggest that the higher mass collected by the high-flow-rate samplers did not interfere with the quartz measurement. A significant portion of the data collected with the high-flow-rate samplers (>82 %) were greater than the limit of detection, which indicates that these samplers are suitable for quantifying exposures, even with low-quartz materials. C1 [Coggins, Marie A.; Healy, Catherine B.] Natl Univ Ireland, Sch Phys, Galway, Ireland. [Lee, Taekhee; Harper, Martin] Ctr Dis Control & Prevent, Exposure Assessment Branch, HELD, NIOSH, Morgantown, WV 26505 USA. RP Coggins, MA (reprint author), Natl Univ Ireland, Sch Phys, Galway, Ireland. NR 23 TC 1 Z9 1 U1 0 U2 0 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 125 EP 138 DI 10.1520/STP156520130141 PG 14 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000008 ER PT S AU Chisholm, WP Lee, T Chirila, M AF Chisholm, William P. Lee, Taekhee Chirila, Madalina BE Harper, M Lee, T TI Determination of Crystalline Silica in Dust at Low Concentrations by Low-Temperature Infrared Spectrometry SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE respirable quartz dust; silica dust; FTIR ID LUNG-CANCER; RESPIRABLE QUARTZ; RISK-ASSESSMENT; QUANTIFICATION; SPECTROSCOPY; DIFFRACTION; RELAXATION; WORKERS AB The American Conference of Governmental Industrial Hygienists (ACGIH) accepted a lower threshold limit value (TLV) for respirable crystalline silica (RCS) exposure of 25 mu g/m(3), half of the previous TLV. This change is problematic because the current standard sampling and measurement practices used by NIOSH, OSHA, and MSHA are not sensitive enough to allow an analyst to confidently determine samples acquired near the TLV. In response to this need for a more sensitive method to analyze respirable dust filter samples for crystalline silica, a modification of current NIOSH infrared spectrometric methods is being developed. The additional sensitivity is gained by performing the infrared absorbance measurements at 77K where absorbance peaks are more intense by virtue of being narrower. A quick-change cryostat has been fabricated such that a sample can be introduced to the spectrometer and cooled to 77K in 5 min, interrogated for 1min, and removed and the cryostat readied for another sample in 2 min, for a turnaround time of 8 min per sample, which is brief compared to the time required to prepare and redeposit a sample. Therefore, samples can be acquired and interrogated with legacy samplers, filters, pumps, spectrometers, and sample preparation, the only modification being the addition of a cryostat to the spectrometer. Preliminary experiments demonstrate that the peak-to-background ratio of the quartz signature band near 800 cm(-1) increases by approximately 50 % on cooling from room temperature to 77 K. The slopes of the calibration curve derived from standards interrogated at both room temperature and 77K indicate that the low-temperature method is approximately 25 % more sensitive. C1 [Chisholm, William P.; Lee, Taekhee; Chirila, Madalina] Ctr Dis Control & Prevent, Exposure Assessment Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV 26505 USA. RP Chisholm, WP (reprint author), Ctr Dis Control & Prevent, Exposure Assessment Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV 26505 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 169 EP 179 DI 10.1520/STP156520130029 PG 11 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000010 ER PT S AU Yu, LL Fassett, JD MacDonald, BS Butler, TA Ramsey, DM Key-Schwartz, RJ Rains, TC AF Yu, Lee L. Fassett, John D. MacDonald, Bruce S. Butler, Therese A. Ramsey, Dawn M. Key-Schwartz, Rosa J. Rains, Theodore C. BE Harper, M Lee, T TI Development of SRMs 295x and 296x, Respirable Crystalline Silica on Filter SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE respirable; alpha quartz; cristobalite; ICP-OES; Standard Reference Material; SRM; uncertainty budget; combining results AB Standard Reference Material (SRM VR) series 2951 to 2958 (5 mu g to 1000 mu g) Respirable Alpha Quartz on Filter and SRM series 2961 to 2967 (5 mu g to 1000 mu g) Respirable Cristobalite on Filter were prepared gravimetrically by depositing SRM 1878 a Respirable Alpha Quartz and SRM 1879 a Respirable Cristobalite on filters, respectively. These new SRMs are developed to assure the quality of respirable crystalline silica measurements using x-ray diffraction and infrared spectrometry around the regulatory limits that are enforced by the Occupational Safety and Health Administration (OSHA). The mass of silica determined by highly sensitive, but non-polymorph-specific, inductively coupled plasma optical emission spectrometry (ICP-OES) was successfully used to calculate the mass of polymorph-specific crystalline silica on filter after all sources of Si on the new SRMs were carefully analyzed. The certified values of alpha quartz in SRMs 2951 to 2958 and cristobalite in SRMs 2961 to 2967, respectively, were established from the gravimetric preparation values and the spectrometric measurement values. C1 [Yu, Lee L.; Fassett, John D.; MacDonald, Bruce S.; Butler, Therese A.] NIST, Gaithersburg, MD 20899 USA. [Ramsey, Dawn M.; Key-Schwartz, Rosa J.] NIOSH, Cincinnati, OH 45226 USA. [Rains, Theodore C.] High Pur Stand, Charleston, SC USA. RP Yu, LL (reprint author), NIST, Gaithersburg, MD 20899 USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 222 EP 231 DI 10.1520/STP156512239 PG 10 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000014 ER PT S AU Hayes, T Parish, H Key-Schwartz, R Popp, D AF Hayes, Terry Parish, Helen Key-Schwartz, Rosa Popp, Derek BE Harper, M Lee, T TI An Evaluation of Aerosol- and Liquid-Generated Silica Samples for Proficiency Analytical Testing SO SILICA AND ASSOCIATED RESPIRABLE MINERAL PARTICLES SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT Symposium on Silica and Associated Respirable Mineral Particles CY OCT 25-26, 2012 CL Atlanta, GA SP ASTM Int, Comm D22 Air Qual, ASTM Int, Subcommittee D22 04 Workplace Air Qual DE proficiency analytical testing; Fourier transform infrared spectrometry (FTIR); X-ray diffraction (XRD); silica; aerosol-generation; liquid-generation AB SRI International has prepared dynamically generated silica samples since 1980 for the National Institute of Occupational Safety and Health (NIOSH) and the American Industrial Hygiene Association (AIHA) Proficiency Analytical Testing (PAT) programs. Aerosol-generated samples were developed in 1980 to more closely approximate real world samples and to improve intrabatch precision. Liquid-generated samples may provide tighter control limits, and this method has been reexamined as the generation procedure of choice. Sample preparation procedures have also been investigated to minimize analytical uncertainty and, hence, obtain a true evaluation of the sampling error. Samples were analyzed by SRI, NIOSH, and the Wisconsin Occupational Health Laboratory, using X-ray diffraction or Fourier transform infrared spectrometry (FTIR). Results were plotted and statistically evaluated, then compared to the existing PAT interlaboratory database. C1 [Hayes, Terry] SRI Int, Analyt Chem, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. [Parish, Helen] SRI Int, Dept Analyt Chem, Menlo Pk, CA 94025 USA. [Key-Schwartz, Rosa] NIOSH, Alice Hamilton Lab, Cincinnati, OH 45213 USA. [Popp, Derek] Wisconsin State Lab Hyg, Wisconsin Occupat Hlth Lab, Madison, WI 53707 USA. RP Hayes, T (reprint author), SRI Int, Analyt Chem, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. EM terry.hayes@sri.com NR 4 TC 0 Z9 0 U1 0 U2 0 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7551-8 J9 AM SOC TEST MATER PY 2014 VL 1565 BP 232 EP 240 DI 10.1520/STP156512243 PG 9 WC Public, Environmental & Occupational Health; Materials Science, Characterization & Testing SC Public, Environmental & Occupational Health; Materials Science GA BE4GE UT WOS:000371678000015 ER PT J AU Hudson, NL Kasner, EJ Beckman, J Mehler, L Schwartz, A Higgins, S Bonnar-Prado, J Lackovic, M Mulay, P Mitchell, Y Larios, L Walker, R Waltz, J Moraga-McHaley, S Roisman, R Calvert, GM AF Hudson, Naomi L. Kasner, Edward J. Beckman, John Mehler, Louise Schwartz, Abby Higgins, Sheila Bonnar-Prado, Joanne Lackovic, Michelle Mulay, Prakash Mitchell, Yvette Larios, Leo Walker, Rob Waltz, Justin Moraga-McHaley, Stephanie Roisman, Rachel Calvert, Geoffrey M. TI Characteristics and Magnitude of Acute Pesticide-Related Illnesses and Injuries Associated With Pyrethrin and Pyrethroid Exposures-11 States, 2000-2008 SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE pyrethrin; pyrethroid; surveillance; pesticide; illness ID INSECTICIDES AB Background Excluding disinfectants, pyrethrins and pyrethroids are the pesticides used most commonly in and around homes. Respiratory effects and paresthesia are among the concerns about pyrethrin/pyrethroid exposures. MethodsAcute pesticide-related illness/injury cases were identified from the Sentinel Event Notification System for Occupational Risks-Pesticides Program and the California Department of Pesticide Regulation from 2000-2008. Characteristics and incidence rates were determined for acute pyrethrin/pyrethroid-related illness/injury cases. Logistic regression analyses were performed to determine odds of respiratory and dermal symptoms in persons with illness/injury following pyrethrin/pyrethroid exposure compared to persons with illness/injury following exposure to other pesticides. ResultsA total of 4,974 cases of acute pyrethrin/pyrethroid-related illness were identified. Incidence rates increased over time, reaching 8 cases/million population in 2008. The majority of cases were low severity (85%) and 34% were work-related. Respiratory effects were the most common symptoms reported (48%). Risk of acute respiratory effects were significantly elevated among persons exposed only to pyrethrins (adjusted odds ratio [aOR] 1.79; 95% confidence interval [95% CI]: 1.49-2.16), only to pyrethroids (aOR 1.99 95% CI: 1.77-2.24), to a mixture of pyrethroids (aOR 2.36; 95% CI: 1.99-2.81) or to a mixture containing both pyrethrins and pyrethroids (aOR 2.99; 95% CI: 2.33-3.84) compared to those with illness arising from exposure to other pesticides. The most common factors contributing to pyrethrin/pyrethroid-related illness included exposure from spills/splashes, improper storage, and failure to evacuate during pesticide application. ConclusionsThe magnitude of acute pyrethrin/pyrethroid-related illness/injury is relatively low but is increasing. As such, additional measures to prevent them are needed. Am. J. Ind. Med. 57:15-30, 2014. (c) 2013 Wiley Periodicals, Inc. C1 [Hudson, Naomi L.; Kasner, Edward J.; Calvert, Geoffrey M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Beckman, John; Roisman, Rachel] Calif Dept Publ Hlth, Richmond, CA USA. [Beckman, John] Inst Publ Hlth, Oakland, CA USA. [Mehler, Louise] Calif Dept Pesticide Regulat, Sacramento, CA USA. [Schwartz, Abby] Michigan Dept Community Hlth, Div Environm Hlth, Lansing, MI USA. [Higgins, Sheila] North Carolina Dept Hlth & Human Serv, Div Publ Hlth, Raleigh, NC USA. [Bonnar-Prado, Joanne] Washington State Dept Hlth, Off Environm Hlth Safety & Toxicol, Olympia, WA USA. [Lackovic, Michelle] Louisiana Dept Hlth & Hosp, New Orleans, LA USA. [Mulay, Prakash] Florida Dept Hlth, Tallahassee, FL USA. [Mitchell, Yvette] New York State Dept Hlth, Bur Occupat Hlth & Injury Prevent, Troy, NY USA. [Larios, Leo] Texas Dept State Hlth Serv, Environm & Injury Epidemiol & Toxicol Unit, Austin, TX USA. [Walker, Rob] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Waltz, Justin] Oregon Hlth Author, Off Environm Publ Hlth, Portland, OR USA. [Moraga-McHaley, Stephanie] New Mexico Dept Hlth, Albuquerque, NM USA. RP Calvert, GM (reprint author), NIOSH, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM jac6@cdc.gov NR 38 TC 8 Z9 8 U1 3 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD JAN PY 2014 VL 57 IS 1 BP 15 EP 30 DI 10.1002/ajim.22216 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 263DP UT WOS:000327787100003 PM 23788228 ER PT J AU Bang, KM Mazurek, JM Wood, JM Hendricks, SA AF Bang, Ki Moon Mazurek, Jacek M. Wood, John M. Hendricks, Scott A. TI Diseases Attributable to Asbestos Exposure: Years of Potential Life Lost, United States, 1999-2010 SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE years of potential life lost; mortality; asbestos; asbestosis; malignant mesothelioma; lung cancer ID PREMATURE MORTALITY; CANCER; WORK; RISK; AGE AB Background Although asbestos use has been restricted in recent decades, asbestos-associated deaths continue to occur in the United States. ObjectivesWe evaluated premature mortality and loss of potentially productive years of life attributable to asbestos-associated diseases. MethodsUsing 1999-2010 National Center for Health Statistics mortality data, we identified decedents aged 25 years whose death certificate listed asbestosis and malignant mesothelioma as the underlying cause of death. We computed years of potential life lost to life expectancy (YPLL) and to age 65 (YPLL65). ResultsDuring 1999-2010, a total of 427,005 YPLL and 55,184 YPLL65 were attributed to asbestosis (56,907 YPLL and 2,167 YPLL65), malignant mesothelioma (370,098 YPPL and 53,017 YPLL65). Overall and disease-specific asbestos-attributable total YPLL and YPLL65 and median YPLL and YPLL65 per decedent did not change significantly from 1999 to 2010. ConclusionsThe continuing occurrence of asbestos-associated diseases and their substantial premature mortality burden underscore the need for maintaining prevention efforts and for ongoing surveillance to monitor temporal trends in these diseases. Am. J. Ind. Med. 57:38-48, 2014. (c) 2013 Wiley Periodicals, Inc. C1 [Bang, Ki Moon; Mazurek, Jacek M.; Wood, John M.; Hendricks, Scott A.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Bang, KM (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Mailstop H-G900-2 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM kmb2@cdc.gov FU Intramural CDC HHS [CC999999] NR 40 TC 3 Z9 3 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD JAN PY 2014 VL 57 IS 1 BP 38 EP 48 DI 10.1002/ajim.22261 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 263DP UT WOS:000327787100005 PM 24108494 ER PT J AU Luckhaupt, SE Sussell, AL Sweeney, MH Sestito, JP Calvert, GM AF Luckhaupt, Sara E. Sussell, Aaron L. Sweeney, Marie H. Sestito, John P. Calvert, Geoffrey M. TI Prevalence of Work-Related Dermatitis in the Working Population: Authors' Response to Letter from Rosenman and Fussman SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Letter ID ASTHMA; SURVEILLANCE; MICHIGAN C1 [Luckhaupt, Sara E.; Sussell, Aaron L.; Sweeney, Marie H.; Sestito, John P.; Calvert, Geoffrey M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Luckhaupt, SE (reprint author), NIOSH, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM sluckhaupt@cdc.gov NR 8 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD JAN PY 2014 VL 57 IS 1 BP 127 EP 128 DI 10.1002/ajim.22276 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 263DP UT WOS:000327787100015 PM 24307069 ER PT J AU Rasmussen, SA Jamieson, DJ AF Rasmussen, Sonja A. Jamieson, Denise J. TI Maternal mortality due to pandemic influenza A H1N1 2009 virus in Colombia SO JOURNAL OF PERINATAL MEDICINE LA English DT Editorial Material ID PREGNANT-WOMEN; UNITED-STATES; ILLNESS C1 [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Influenza Coordinat Unit, Off Infect Dis, Atlanta, GA 30333 USA. [Jamieson, Denise J.] Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Rasmussen, SA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-28, Atlanta, GA 30333 USA. EM skr9@cdc.gov OI Rasmussen, Sonja/0000-0002-0574-4928 NR 15 TC 0 Z9 0 U1 0 U2 3 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0300-5577 EI 1619-3997 J9 J PERINAT MED JI J. Perinat. Med. PD JAN PY 2014 VL 42 IS 1 BP 27 EP 29 DI 10.1515/jpm-2013-0228 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 262VE UT WOS:000327765200004 PM 24142342 ER PT J AU Sinks, T AF Sinks, Thomas TI Screenings and clusters: a cancer cluster in a chemical plant SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material C1 Natl Ctr Environm Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Sinks, T (reprint author), Natl Ctr Environm Hlth, Ctr Dis Control & Prevent, Mailstop F61,1600 Clifton Rd, Atlanta, GA 30333 USA. EM ths2@cdc.gov NR 8 TC 0 Z9 0 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JAN PY 2014 VL 71 IS 1 BP 2 EP 3 DI 10.1136/oemed-2013-101789 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 263UZ UT WOS:000327834800002 PM 24265265 ER PT B AU Igietseme, JU Zhu, XP Black, CM AF Igietseme, Joseph U. Zhu, Xiaoping Black, Carolyn M. BA Ackerman, ME Nimmerjahn, F BF Ackerman, ME Nimmerjahn, F TI Fc Receptor-Dependent Immunity SO ANTIBODY FC: LINKING ADAPTIVE AND INNATE IMMUNITY LA English DT Article; Book Chapter ID CYTOTOXIC T-LYMPHOCYTES; DENDRITIC CELLS; INTRACELLULAR PATHOGENS; CHLAMYDIA-TRACHOMATIS; MEDIATED PHAGOCYTOSIS; PROTECTIVE IMMUNITY; GAMMA RECEPTORS; INFECTION; ANTIBODIES; MOLECULES C1 [Igietseme, Joseph U.; Black, Carolyn M.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Igietseme, Joseph U.] Morehouse Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30310 USA. [Zhu, Xiaoping] Univ Maryland, College Pk, MD 20742 USA. RP Igietseme, JU (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. NR 53 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-394818-2; 978-0-12-394802-1 PY 2014 BP 269 EP 281 PG 13 WC Immunology SC Immunology GA BHU43 UT WOS:000326685100015 ER PT J AU Olsen, EO Eaton, DK Park, S Brener, ND Blanck, HM AF Olsen, Emily O'Malley Eaton, Danice K. Park, Sohyun Brener, Nancy D. Blanck, Heidi M. TI Comparing Methods for Assessing Beverage Intake among High School Students SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE beverage intake; dietary assessment; adolescents; food frequency questionnaire; Youth Risk Behavior Survey ID FOOD-FREQUENCY QUESTIONNAIRE; RISK BEHAVIOR SURVEILLANCE; UNITED-STATES; RELATIVE VALIDITY; CHILDREN; ADOLESCENTS; REPRODUCIBILITY; RELIABILITY; CONSUMPTION; PREVALENCE AB Objectives: To compare 7 beverage intake survey questions against criterion data from 24-hour dietary recall interviews (24HrDRIs) among adolescents. Methods: Data were available from 610 US high school students completing a survey and >= 3 24HrDRIs. Analyses compared mean intake (times/day) calculated from the survey to intake (servings/day) from the 24HrDRIs. Proportions of students reporting intake of >= 1 times/day were compared to the 24HrDRI results. Results: Survey data significantly correlated with 24HrDRI data (all corrected r: 0.26-0.49). Survey results differed from 24HrDRI results on reported intake of 5 beverages. Conclusion: Intake from these beverage questions should be reported in times/day, which is related to, but not a proxy for, servings/day. These questions are useful for population-level surveillance of beverage C1 [Olsen, Emily O'Malley; Eaton, Danice K.; Brener, Nancy D.] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. [Park, Sohyun; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Olsen, EO (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. EM eolsen@cdc.gov NR 27 TC 2 Z9 2 U1 0 U2 20 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2014 VL 38 IS 1 BP 114 EP 123 DI 10.5993/AJHB.38.1.12 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 219VD UT WOS:000324538100012 ER PT J AU Hall, HI Tang, T Westfall, AO Mugavero, MJ AF Hall, H. Irene Tang, Tian Westfall, Andrew O. Mugavero, Michael J. TI HIV Care Visits and Time to Viral Suppression, 19 US Jurisdictions, and Implications for Treatment, Prevention and the National HIV/AIDS Strategy SO PLOS ONE LA English DT Article ID INFECTED PERSONS; ANTIRETROVIRAL TREATMENT; EARLY RETENTION; UNITED-STATES; MEDICAL-CARE; RECOMMENDATIONS; SOCIETY; PANEL; ASSOCIATION; ENGAGEMENT AB Objective: Early and regular care and treatment for human immunodeficiency virus (HIV) infection are associated with viral suppression, reductions in transmission risk and improved health outcomes for persons with HIV. We determined, on a population level, the association of care visits with time from HIV diagnosis to viral suppression. Methods: Using data from 19 areas reporting HIV-related tests to national HIV surveillance, we determined time from diagnosis to viral suppression among 17,028 persons diagnosed with HIV during 2009, followed through December 2011, using data reported through December 2012. Using Cox proportional hazards models, we assessed factors associated with viral suppression, including linkage to care within 3 months of diagnosis, a goal set forth by the National HIV/AIDS Strategy, and number of HIV care visits as determined by CD4 and viral load test results, while controlling for demographic, clinical, and risk characteristics. Results: Of 17,028 persons diagnosed with HIV during 2009 in the 19 areas, 76.6% were linked to care within 3 months of diagnosis and 57.0% had a suppressed viral load during the observation period. Median time from diagnosis to viral suppression was 19 months overall, and 8 months among persons with an initial CD4 count <= 350 cells/mu L. During the first 12 months after diagnosis, persons linked to care within 3 months experienced shorter times to viral suppression (higher rate of viral suppression per unit time, hazard ratio [HR] = 4.84 versus not linked within 3 months; 95% confidence interval [CI] 4.27, 5.48). Persons with a higher number of time- updated care visits also experienced a shorter time to viral suppression (HR = 1.51 per additional visit, 95% CI 1.49, 1.52). Conclusions: Timely linkage to care and greater frequency of care visits were associated with faster time to viral suppression with implications for individual health outcomes and for secondary prevention. C1 [Hall, H. Irene] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. [Tang, Tian] ICF Int, Atlanta, GA USA. [Westfall, Andrew O.; Mugavero, Michael J.] Univ Alabama Birmingham, Ctr AIDS Res, Birmingham, AL USA. [Mugavero, Michael J.] Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA. RP Hall, HI (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. EM ixh1@cdc.gov OI Westfall, Andrew/0000-0002-0468-4695 FU Centers for Disease Control and Prevention (CDC) FX The Centers for Disease Control and Prevention (CDC) provides funding to state and local health departments to conduct surveillance of HIV disease in accordance with their own disease reporting regulations. CDC provides technical guidance for the collection of data by the state and local health departments and data are sent to CDC for national-level analyses. Role of the Sponsors: The CDC reviewed and approved final submission but the findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC. NR 32 TC 17 Z9 17 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 31 PY 2013 VL 8 IS 12 AR e84318 DI 10.1371/journal.pone.0084318 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 284MV UT WOS:000329323900080 PM 24391937 ER PT J AU Talley, LE Boyd, E AF Talley, Leisel E. Boyd, Erin TI Challenges to the Programmatic Implementation of Ready to Use Infant Formula in the Post-Earthquake Response, Haiti, 2010: A Program Review SO PLOS ONE LA English DT Review AB Background and Objectives: Following the 2010 earthquake in Haiti, infant and young child feeding was identified as a priority nutrition intervention. A new approach to support breastfeeding mothers and distribute ready-to-use infant formula (RUIF) to infants unable to breastfeed was established. The objective of the evaluation was to assess the implementation of infant feeding programs using RUIF in displaced persons camps in Port-au-Prince, Haiti during the humanitarian response. Methods: A retrospective record review was conducted from April-July, 2010 to obtain data on infants receiving RUIF in 30 baby tents. A standardized data collection form was created based on data collected across baby tents and included: basic demographics, admission criteria, primary caretaker, feeding practices, and admission and follow-up anthropometrics. Main Findings: Orphans and abandoned infants were the most frequent enrollees (41%) in the program. While the program targeted these groups, it is unlikely that this is a true reflection of population demographics. Despite programmatic guidance, admission criteria were not consistently applied across programs. Thirty-four percent of infants were undernourished (weight for age Z score <-2) at the time of admission. Defaulting accounted for 50% of all program exits and there was no follow-up of these children. Low data quality was a significant barrier. Conclusions: The design, implementation and magnitude of the 'baby tents' using RUIF was novel in response to infant and young child feeding (IYCF) in emergencies and presented multiple challenges that should not be overlooked, including adherence to protocols and the adaption of emergency programs to existing programs. The implementation of IYCF programs should be closely monitored to ensure that they achieve the objectives set by the humanitarian community and national government. IYCF is an often overlooked component of emergency preparedness; however to improve response, generic protocols and pre-emergency training and preparedness should be established for humanitarian agencies. C1 [Talley, Leisel E.] Ctr Dis Control & Prevent, Emergency Response & Recovery Branch, Atlanta, GA 30329 USA. [Boyd, Erin] United Nations Childrens Fund, Nutr Sect, Program Div, New York, NY USA. RP Talley, LE (reprint author), Ctr Dis Control & Prevent, Emergency Response & Recovery Branch, Atlanta, GA 30329 USA. EM Ltalley@cdc.gov NR 12 TC 2 Z9 2 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 31 PY 2013 VL 8 IS 12 AR e84043 DI 10.1371/journal.pone.0084043 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 284MV UT WOS:000329323900020 PM 24391877 ER PT J AU Verani, JR McCracken, J Arvelo, W Estevez, A Lopez, MR Reyes, L Moir, JC Bernart, C Moscoso, F Gray, J Olsen, SJ Lindblade, KA AF Verani, Jennifer R. McCracken, John Arvelo, Wences Estevez, Alejandra Renee Lopez, Maria Reyes, Lissette Carlos Moir, Juan Bernart, Chris Moscoso, Fabiola Gray, Jennifer Olsen, Sonja J. Lindblade, Kim A. TI Surveillance for Hospitalized Acute Respiratory Infection in Guatemala SO PLOS ONE LA English DT Article ID COMMUNITY-ACQUIRED PNEUMONIA; SYNCYTIAL VIRUS-INFECTIONS; CLINICAL CHARACTERISTICS; YOUNG-CHILDREN; EPIDEMIOLOGY; DIAGNOSIS; ETIOLOGY; RADIOGRAPHS; POPULATION; AMERICA AB Acute respiratory infections (ARI) are an important cause of illness and death worldwide, yet data on the etiology of ARI and the population-level burden in developing countries are limited. Surveillance for ARI was conducted at two hospitals in Guatemala. Patients admitted with at least one sign of acute infection and one sign or symptom of respiratory illness met the criteria for a case of hospitalized ARI. Nasopharyngeal/oropharyngeal swabs were collected and tested by polymerase chain reaction for adenovirus, parainfluenza virus types 1,2 and 3, respiratory syncytial virus, influenza A and B viruses, human metapneumovirus, Chlamydia pneumioniae, and Mycoplasma pneumoniae. Urine specimens were tested for Streptococcus pneumoniae antigen. Blood culture and chest radiograph were done at the discretion of the treating physician. Between November 2007 and December 2011, 3,964 case-patients were enrolled. While cases occurred among all age groups, 2,396 (60.4%) cases occurred in children <5 years old and 463 (11.7%) among adults >= 65 years old. Viruses were found in 52.6% of all case-patients and 71.8% of those aged <1 year old; the most frequently detected was respiratory syncytial virus, affecting 26.4% of case-patients. Urine antigen testing for Streptococcus pneumoniae performed for case-patients >= 15 years old was positive in 15.1% of those tested. Among 2,364 (59.6%) of case-patients with a radiograph, 907 (40.0%) had findings suggestive of bacterial pneumonia. Overall, 230 (5.9%) case-patients died during the hospitalization. Using population denominators, the observed hospitalized ARI incidence was 128 cases per 100,000, with the highest rates seen among children <1 year old (1,703 per 100,000), followed by adults >= 65 years old (292 per 100,000). These data, which demonstrate a substantial burden of hospitalized ARI in Guatemala due to a variety of pathogens, can help guide public health policies aimed at reducing the burden of illness and death due to respiratory infections. C1 [Verani, Jennifer R.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. [McCracken, John; Estevez, Alejandra; Renee Lopez, Maria; Bernart, Chris; Moscoso, Fabiola; Gray, Jennifer] Univ Valle Guatemala, Ctr Estudios Salud, Guatemala City, Guatemala. [Arvelo, Wences; Lindblade, Kim A.] Ctr Dis Control & Prevent, Reg Off Cent Amer & Panama, Int Emerging Infect Program, Guatemala City, Guatemala. [Arvelo, Wences; Lindblade, Kim A.] Ctr Dis Control & Prevent, Div Global Dis Detect & Emergency Response, Atlanta, GA USA. [Reyes, Lissette] Minist Salud Publ & Asistencia Social, Field Epidemiol Training Program, Guatemala City, Guatemala. [Reyes, Lissette] Minist Salud Publ & Asistencia Social, Area Salud Santa Rosa, Cuilapa, Guatemala. [Carlos Moir, Juan] Minist Salud Publ & Asistencia Social, Area Salud Quetzaltenango, Quetzaltenango, Guatemala. [Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Verani, JR (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. EM qzr7@cdc.gov FU United States Centers for Disease Control and Prevention (CDC) [UO1 GH000028-02] FX This publication was supported by Cooperative Agreement Number UO1 GH000028-02 from the United States Centers for Disease Control and Prevention (CDC). The CDC participated in all aspects of study design, data collection, data analysis and manuscript preparation. NR 50 TC 12 Z9 12 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 31 PY 2013 VL 8 IS 12 AR e83600 DI 10.1371/journal.pone.0083600 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 284NF UT WOS:000329325200089 PM 24391792 ER PT J AU Bosch, FX Broker, TR Forman, D Moscicki, AB Gillison, ML Doorbar, J Stern, PL Stanley, M Arbyn, M Poljak, M Cuzick, J Castle, PE Schiller, JT Markowitz, LE Fisher, WA Canfell, K Denny, LA Franco, EL Steben, M Kane, MA Schiffman, M Meijer, CJLM Sankaranarayanan, R Castellsague, X Kim, JJ Brotons, M Alemany, L Albero, G Diaz, M de Sanjose, S AF Xavier Bosch, F. Broker, Thomas R. Forman, David Moscicki, Anna-Barbara Gillison, Maura L. Doorbar, John Stern, Peter L. Stanley, Margaret Arbyn, Marc Poljak, Mario Cuzick, Jack Castle, Philip E. Schiller, John T. Markowitz, Lauri E. Fisher, William A. Canfell, Karen Denny, Lynette A. Franco, Eduardo L. Steben, Marc Kane, Mark A. Schiffman, Mark Meijer, Chris J. L. M. Sankaranarayanan, Rengaswamy Castellsague, Xavier Kim, Jane J. Brotons, Maria Alemany, Laia Albero, Ginesa Diaz, Mireia de Sanjose, Silvia CA ICO Monograph 'Comprehensive Conto TI Comprehensive Control of Human Papillomavirus Infections and Related Diseases SO VACCINE LA English DT Review DE HPV; Cervical cancer; Anal cancer; Penile cancer; Vaginal cancer ID CERVICAL-CANCER; PREVENTION; COUNTRIES; VACCINES; WORLD AB Infection with human papillomavirus (HPV) is recognized as one of the major causes of infection-related cancer worldwide, as well as the causal factor in other diseases. Strong evidence for a causal etiology with HPV has been stated by the International Agency for Research on Cancer for cancers of the cervix uteri, penis, vulva, vagina, anus and oropharynx (including base of the tongue and tonsils). Of the estimated 12.7 million new cancers occurring in 2008 worldwide, 4.8% were attributable to HPV infection, with substantially higher incidence and mortality rates seen in developing versus developed countries. In recent years, we have gained tremendous knowledge about HPVs and their interactions with host cells, tissues and the immune system; have validated and implemented strategies for safe and efficacious prophylactic vaccination against HPV infections; have developed increasingly sensitive and specific molecular diagnostic tools for HPV detection for use in cervical cancer screening; and have substantially increased global awareness of HPV and its many associated diseases in women, men, and children. While these achievements exemplify the success of biomedical research in generating important public health interventions, they also generate new and daunting challenges: costs of HPV prevention and medical care, the implementation of what is technically possible, socio-political resistance to prevention opportunities, and the very wide ranges of national economic capabilities and health care systems. Gains and challenges faced in the quest for comprehensive control of HPV infection and HPV-related cancers and other disease are summarized in this review. The information presented may be viewed in terms of a reframed paradigm of prevention of cervical cancer and other HPV-related diseases that will include strategic combinations of at least four major components: 1) routine introduction of HPV vaccines to women in all countries, 2) extension and simplification of existing screening programs using HPV-based technology, 3) extension of adapted screening programs to developing populations, and 4) consideration of the broader spectrum of cancers and other diseases preventable by HPV vaccination in women, as well as in men. Despite the huge advances already achieved, there must be ongoing efforts including international advocacy to achieve widespread optimally universal implementation of HPV prevention strategies in both developed and developing countries. This article summarizes information from the chapters presented in a special ICO Monograph 'Comprehensive Control of HPV Infections and Related Diseases' Vaccine Volume 30, Supplement 5, 2012. Additional details on each subtopic and full information regarding the supporting literature references may be found in the original chapters. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Xavier Bosch, F.; Castellsague, Xavier; Brotons, Maria; Alemany, Laia; Albero, Ginesa; Diaz, Mireia; de Sanjose, Silvia] IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. [Broker, Thomas R.] Univ Alabama Birmingham, Birmingham, AL USA. [Forman, David] Int Agcy Res Canc, Sect Canc Informat, F-69372 Lyon, France. [Moscicki, Anna-Barbara] Univ Calif San Francisco, Dept Pediat, Div Adolescent Med, San Francisco, CA USA. [Gillison, Maura L.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Doorbar, John] Natl Inst Med Res, Div Virol, London NW7 1AA, England. [Stern, Peter L.] Univ Manchester, Paterson Inst Canc Res, Manchester, Lancs, England. [Stanley, Margaret] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Arbyn, Marc] Sci Inst Publ Hlth, Canc Epidemiol Unit, Brussels, Belgium. [Arbyn, Marc] Univ Antwerp, Lab Cell Biol & Histol, B-2020 Antwerp, Belgium. [Poljak, Mario] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia. [Cuzick, Jack] Queen Mary Univ London, Wolfson Inst Prevent Med, London, England. [Castle, Philip E.] Global Canc Initiat, Chestertown, MD USA. [Schiller, John T.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Markowitz, Lauri E.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. [Fisher, William A.] Univ Western Ontario, Dept Psychol, Social Sci Ctr 7428, London, ON, Canada. [Fisher, William A.] Univ Western Ontario, Dept Obstet & Gynaecol, Social Sci Ctr 7428, London, ON, Canada. [Canfell, Karen] Univ NSW, Prince Wales Clin Sch, Lowy Canc Res Ctr, Newcastle, NSW, Australia. [Canfell, Karen] NSW Canc Council, Canc Epidemiol Res Unit, Sydney, NSW, Australia. [Denny, Lynette A.] Univ Cape Town, Groote Schuur Hosp, Dept Obstet & Gynaecol, ZA-7925 Cape Town, South Africa. [Denny, Lynette A.] Univ Cape Town, Groote Schuur Hosp, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. [Franco, Eduardo L.] McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada. [Steben, Marc] Inst Natl Sante Publ Quebec, Montreal, PQ, Canada. [Kane, Mark A.] Consultant Immunizat Policy, Mercer Isl, WA USA. [Schiffman, Mark] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Meijer, Chris J. L. M.] Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands. [Sankaranarayanan, Rengaswamy] Int Agcy Res Canc, Screening Grp, F-69372 Lyon, France. [Castellsague, Xavier; Alemany, Laia; Albero, Ginesa; de Sanjose, Silvia] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain. [Kim, Jane J.] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Hlth Decis Sci, Boston, MA 02115 USA. RP Bosch, FX (reprint author), IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. EM admincerp@iconcologia.net RI de Sanjose Llongueras, Silvia/H-6339-2014; Bruni, Laia/N-5816-2014; BOSCH JOSE, FRANCESC XAVIER/J-6339-2012; Castellsague Pique, Xavier/N-5795-2014; DIAZ SANCHIS, MIREIA/H-6335-2014; Albero, Ginesa/G-7248-2015; OI Bruni, Laia/0000-0003-3943-0326; BOSCH JOSE, FRANCESC XAVIER/0000-0002-7172-3412; Castellsague Pique, Xavier/0000-0002-0802-3595; Albero, Ginesa/0000-0002-9400-1914; Kjaer, Susanne/0000-0002-8347-1398; Franco, Eduardo/0000-0002-4409-8084 FU European Commission [HEALTH-F3-2010-242061, HEALTH-F2-2011-282562, 242061]; Instituto de Salud Carlos III (Spanish Government) [FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, CIBERESP]; Agencia de Gestio d'Ajuts Universitaris i de Recerca Generalitat de Catalunya (Catalonian Government) [AGAUR 2005SGR00695, AGAUR 2009SGR126]; USPHS/NIH/National Cancer Institute [CA36200, CA83679]; US Public Health Service (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) [R37 CA51323]; National Institute of AIDS and Infectious Disease [RC1 AI86051]; UK Medical Research Council [MC_U117584278]; Belgian Foundation Against Cancer (Brussels, Belgium); International Agency for Research on Cancer (Lyon, France); Cancer Research UK [A10404]; National Health and Medical Research Council, Australia [CDF APP1007994, 1007518]; Bill and Melinda Gates Foundation, USA [35537]; U.S. National Cancer Institute [U54 CA164336, R01 CA160744-01A1]; Bill and Melinda Gates Foundation [30505]; Cancer Council NSW, Australia FX The work was partially supported by public grants from the European Commission (7th Framework Programme grants HEALTH-F3-2010-242061, PREHDICT and HEALTH-F2-2011-282562, HPV AHEAD), from the Instituto de Salud Carlos III (Spanish Government) (grants FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056 and CIBERESP) and from the Agencia de Gestio d'Ajuts Universitaris i de Recerca Generalitat de Catalunya (Catalonian Government) (grants AGAUR 2005SGR00695 and AGAUR 2009SGR126), who had no role in data collection, analysis or interpretation of results. Thomas R. Broker receives research support from the USPHS/NIH/National Cancer Institute (grants "Human Papillomavirus Gene Expression" CA36200 and "Mechanisms of Human Papillomavirus DNA Replication" CA83679). Anna-Barbara Moscicki's work is supported by US Public Health Service grant R37 CA51323 (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) and National Institute of AIDS and Infectious Disease RC1 AI86051. John Doorbar is funded by the UK Medical Research Council through program grant MC_U117584278 (Molecular Biology of Human Papillomavirus Infection). Marc Arbyn received financial support from: (1) the 7th Framework Programme of DG Research of the European Commission through the PREHDICT project (grant No. 242061, coordinated by the Vrije Universiteit Amsterdam, the Netherlands) and through the HPV AHEAD Network (FP7-HEALTH-2011-282562); (2) the Belgian Foundation Against Cancer (Brussels, Belgium); and (3) the International Agency for Research on Cancer (Lyon, France). Jack Cuzick was supported in part by Cancer Research UK programme grant A10404. Karen Canfell is supported by grants from the National Health and Medical Research Council, Australia (CDF APP1007994 and Project Grant #1007518), by non-commercial government and academic consulting agreements in Australia, New Zealand and the UK, and by Cancer Council NSW, Australia. Lynette A. Denny was partially supported by Bill and Melinda Gates Foundation, USA (35537). The work of Chris J.L.M. Meijer received support via the 7th Framework Programme of DG Research of the European commission through the PREHDICT project (grant 242061, coordinated via the Vrije Universiteit Amsterdam). Jane J. Kim is supported in part by grants from the U.S. National Cancer Institute (U54 CA164336, R01 CA160744-01A1) and the Bill and Melinda Gates Foundation (30505) for modeling of HPV and cervical cancer in developing countries. NR 20 TC 15 Z9 20 U1 8 U2 42 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 31 PY 2013 VL 31 SU 7 BP H1 EP H31 DI 10.1016/j.vaccine.2013.10.003 PG 31 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 288HM UT WOS:000329602600003 PM 24332295 ER PT J AU Bosch, FX Broker, TR Forman, D Moscicki, AB Gillison, ML Doorbar, J Stern, PL Stanley, M Arbyn, M Poljak, M Cuzick, J Castle, PE Schiller, JT Markowitz, LE Fisher, WA Canfell, K Denny, LA Franco, EL Steben, M Kane, MA Schiffman, M Meijer, CJLM Sankaranarayanan, R Castellsague, X Kim, JJ Brotons, M Alemany, L Albero, G Diaz, M de Sanjose, S AF Xavier Bosch, F. Broker, Thomas R. Forman, David Moscicki, Anna-Barbara Gillison, Maura L. Doorbar, John Stern, Peter L. Stanley, Margaret Arbyn, Marc Poljak, Mario Cuzick, Jack Castle, Philip E. Schiller, John T. Markowitz, Lauri E. Fisher, William A. Canfell, Karen Denny, Lynette A. Franco, Eduardo L. Steben, Marc Kane, Mark A. Schiffman, Mark Meijer, Chris J. L. M. Sankaranarayanan, Rengaswamy Castellsague, Xavier Kim, Jane J. Brotons, Maria Alemany, Laia Albero, Ginesa Diaz, Mireia de Sanjose, Silvia CA ICO Monograph 'Comprehensive Contr TI Comprehensive Control of Human Papillomavirus Infections and Related Diseases SO VACCINE LA English DT Review DE HPV; Cervical cancer; Anal cancer; Penile cancer; Vaginal cancer; Vulvar cancer; Oropharyngeal cancer; Screening; HPV vaccination; HPV testing; Prevention ID CERVICAL-CANCER; PREVENTION; COUNTRIES; VACCINES; WORLD AB Infection with human papillomavirus (HPV) is recognized as one of the major causes of infection-related cancer worldwide, as well as the causal factor in other diseases. Strong evidence for a causal etiology with HPV has been stated by the International Agency for Research on Cancer for cancers of the cervix uteri, penis, vulva, vagina, anus and oropharynx (including base of the tongue and tonsils). Of the estimated 12.7 million new cancers occurring in 2008 worldwide, 4.8% were attributable to HPV infection, with substantially higher incidence and mortality rates seen in developing versus developed countries. In recent years, we have gained tremendous knowledge about HPVs and their interactions with host cells, tissues and the immune system; have validated and implemented strategies for safe and efficacious prophylactic vaccination against HPV infections; have developed increasingly sensitive and specific molecular diagnostic tools for HPV detection for use in cervical cancer screening; and have substantially increased global awareness of HPV and its many associated diseases in women, men, and children. While these achievements exemplify the success of biomedical research in generating important public health interventions, they also generate new and daunting challenges: costs of HPV prevention and medical care, the implementation of what is technically possible, socio-political resistance to prevention opportunities, and the very wide ranges of national economic capabilities and health care systems. Gains and challenges faced in the quest for comprehensive control of HPV infection and HPV-related cancers and other disease are summarized in this review. The information presented may be viewed in terms of a reframed paradigm of prevention of cervical cancer and other HPV-related diseases that will include strategic combinations of at least four major components: 1) routine introduction of HPV vaccines to women in all countries, 2) extension and simplification of existing screening programs using HPV-based technology, 3) extension of adapted screening programs to developing populations, and 4) consideration of the broader spectrum of cancers and other diseases preventable by HPV vaccination in women, as well as in men. Despite the huge advances already achieved, there must be ongoing efforts including international advocacy to achieve widespread-optimally universal-implementation of HPV prevention strategies in both developed and developing countries. This article summarizes information from the chapters presented in a special ICO Monograph 'Comprehensive Control of HPV Infections and Related Diseases' Vaccine Volume 30, Supplement 5, 2012. Additional details on each subtopic and full information regarding the supporting literature references may be found in the original chapters. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Xavier Bosch, F.; Castellsague, Xavier; Kim, Jane J.; Brotons, Maria; Alemany, Laia; Albero, Ginesa; Diaz, Mireia; de Sanjose, Silvia] IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. [Broker, Thomas R.] Univ Alabama Birmingham, Birmingham, AL USA. [Forman, David] Int Agcy Res Canc, Sect Canc Informat, F-69372 Lyon, France. [Moscicki, Anna-Barbara] Univ Calif San Francisco, Dept Pediat, Div Adolescent Med, San Francisco, CA USA. [Gillison, Maura L.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH USA. [Doorbar, John] Natl Inst Med Res, Div Virol, London NW7 1AA, England. [Stern, Peter L.] Univ Manchester, Paterson Inst Canc Res, Manchester, Lancs, England. [Stanley, Margaret] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Arbyn, Marc] Sci Inst Publ Hlth, Canc Epidemiol Unit, Brussels, Belgium. [Arbyn, Marc] Univ Antwerp, Lab Cell Biol & Histol, B-2020 Antwerp, Belgium. [Poljak, Mario] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia. [Cuzick, Jack] Queen Mary Univ London, Wolfson Inst Prevent Med, London, England. [Castle, Philip E.] Global Canc Initiat, Chestertown, MD USA. [Schiller, John T.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Markowitz, Lauri E.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. [Fisher, William A.] Univ Western Ontario, Dept Psychol, Social Sci Ctr, London, ON, Canada. [Fisher, William A.] Univ Western Ontario, Dept Obstet & Gynaecol, Social Sci Ctr, London, ON, Canada. [Canfell, Karen] Univ NSW, Prince Wales Clin Sch, Lowy Canc Res Ctr, Sydney, NSW, Australia. [Canfell, Karen] NSW Canc Council, Canc Epidemiol Res Unit, Sydney, NSW, Australia. [Denny, Lynette A.] Univ Cape Town, Groote Schuur Hosp, Dept Obstet & Gynaecol, ZA-7925 Cape Town, South Africa. [Denny, Lynette A.] Univ Cape Town, Groote Schuur Hosp, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. [Franco, Eduardo L.] McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada. [Steben, Marc] Inst Natl Sante Publ Quebec, Montreal, PQ, Canada. [Kane, Mark A.] Consultant Immunizat Policy, Mercer Isl, WA USA. [Schiffman, Mark] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Meijer, Chris J. L. M.] Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands. [Sankaranarayanan, Rengaswamy] Int Agcy Res Canc, Screening Grp, F-69372 Lyon, France. [Castellsague, Xavier; Alemany, Laia; Albero, Ginesa; de Sanjose, Silvia] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain. [Kim, Jane J.] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Hlth Decis Sci, Boston, MA 02115 USA. RP Bosch, FX (reprint author), IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. EM admincerp@iconcologia.net RI de Sanjose Llongueras, Silvia/H-6339-2014; Bruni, Laia/N-5816-2014; BOSCH JOSE, FRANCESC XAVIER/J-6339-2012; Castellsague Pique, Xavier/N-5795-2014; DIAZ SANCHIS, MIREIA/H-6335-2014; Albero, Ginesa/G-7248-2015; OI BOSCH JOSE, FRANCESC XAVIER/0000-0002-7172-3412; Castellsague Pique, Xavier/0000-0002-0802-3595; Albero, Ginesa/0000-0002-9400-1914; Kjaer, Susanne/0000-0002-8347-1398; Bruni, Laia/0000-0003-3943-0326; Franco, Eduardo/0000-0002-4409-8084 FU European Commission [HEALTH-F3-2010-242061, HEALTH-F2-2011-282562]; Instituto de Salud Carlos III (Spanish Government) [FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, CIBERESP]; Agencia de Gestio d'Ajuts Universitaris i de Recerca - Generalitat de Catalunya (Catalonian Government) [AGAUR 2005SGR00695, AGAUR 2009SGR126]; USPHS/NIH/National Cancer Institute [CA36200, CA83679]; US Public Health Service grant (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) [R37 CA51323]; National Institute of AIDS and Infectious Disease [RC1 AI86051]; UK Medical Research Council [MC_U117584278]; European Commission through the PREHDICT project [242061]; European Commission through HPV AHEAD Network [FP7-HEALTH-2011-282562]; Belgian Foundation Against Cancer (Brussels, Belgium); International Agency for Research on Cancer (Lyon, France); Cancer Research UK [A10404]; National Health and Medical Research Council, Australia [CDF APP1007994, 1007518]; Cancer Council NSW, Australia; Bill and Melinda Gates Foundation, USA [35537]; U.S. National Cancer Institute [U54 CA164336, R01 CA160744-01A1]; Bill and Melinda Gates Foundation [30505] FX The work was partially supported by public grants from the European Commission (7th Framework Programme grants HEALTH-F3-2010-242061, PREHDICT and HEALTH-F2-2011-282562, HPV AHEAD), from the Instituto de Salud Carlos III (Spanish Government) (grants FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056 and CIBERESP) and from the Agencia de Gestio d'Ajuts Universitaris i de Recerca - Generalitat de Catalunya (Catalonian Government) (grants AGAUR 2005SGR00695 and AGAUR 2009SGR126), who had no role in data collection, analysis or interpretation of results. Thomas R. Broker receives research support from the USPHS/NIH/National Cancer Institute (grants "Human Papillomavirus Gene Expression" CA36200 and "Mechanisms of Human Papillomavirus DNA Replication" CA83679). Anna-Barbara Moscicki's work is supported by US Public Health Service grant R37 CA51323 (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) and National Institute of AIDS and Infectious Disease RC1 AI86051. John Doorbar is funded by the UK Medical Research Council through program grant MC_U117584278 (Molecular Biology of Human Papillomavirus Infection). Marc Arbyn received financial support from: (1) the 7th Framework Programme of DG Research of the European Commission through the PREHDICT project (grant No. 242061, coordinated by the Vrije Universiteit Amsterdam, the Netherlands) and through the HPV AHEAD Network (FP7-HEALTH-2011-282562); (2) the Belgian Foundation Against Cancer (Brussels, Belgium); and (3) the International Agency for Research on Cancer (Lyon, France). Jack Cuzick was supported in part by Cancer Research UK programme grant A10404. Karen Canfell is supported by grants from the National Health and Medical Research Council, Australia (CDF APP1007994 and Project Grant #1007518), by non-commercial government and academic consulting agreements in Australia, New Zealand and the UK, and by Cancer Council NSW, Australia. Lynette A. Denny was partially supported by Bill and Melinda Gates Foundation, USA (35537). The work of Chris J.L.M. Meijer received support via the 7th Framework Programme of DG Research of the European commission through the PREHDICT project (grant 242061, coordinated via the Vrije Universiteit Amsterdam). Jane J. Kim is supported in part by grants from the U.S. National Cancer Institute (U54 CA164336, R01 CA160744-01A1) and the Bill and Melinda Gates Foundation (30505) for modeling of HPV and cervical cancer in developing countries. NR 20 TC 0 Z9 1 U1 1 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 30 PY 2013 VL 31 SU 6 BP G1 EP G31 DI 10.1016/j.vaccine.2013.10.002 PG 31 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289LR UT WOS:000329684500003 PM 24331817 ER PT J AU Parashar, UD Nelson, EAS Kang, G AF Parashar, Umesh D. Nelson, E. Anthony S. Kang, Gagandeep TI Diagnosis, management, and prevention of rotavirus gastroenteritis in children SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Editorial Material ID PLACEBO-CONTROLLED TRIAL; CLINICAL SEVERITY; SEVERE DIARRHEA; RISK-FACTORS; VACCINE; INFECTION; INTUSSUSCEPTION; INFANTS; HOSPITALIZATION; MEXICO C1 [Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Nelson, E. Anthony S.] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China. [Kang, Gagandeep] Christian Med Coll & Hosp, Div Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India. RP Parashar, UD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM uap2@cdc.gov OI Nelson, Edmund Anthony Severn/0000-0002-2521-3403 NR 69 TC 14 Z9 14 U1 0 U2 7 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD DEC 30 PY 2013 VL 347 AR f7204 DI 10.1136/bmj.f7204 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 285PM UT WOS:000329406100001 PM 24379214 ER PT J AU Bosch, FX Broker, TR Forman, D Moscicki, AB Gillison, ML Doorbar, J Stern, PL Stanley, M Arbyn, M Poljak, M Cuzick, J Castle, PE Schiller, JT Markowitz, LE Fisher, WA Canfell, K Denny, LA Franco, EL Steben, M Kane, MA Schiffman, M Meijer, CJLM Sankaranarayanan, R Castellsague, X Kim, JJ Brotons, M Alemanya, L Albero, G Diaz, M de Sanjose, S AF Bosch, F. Xavier Broker, Thomas R. Forman, David Moscicki, Anna-Barbara Gillison, Maura L. Doorbar, John Stern, Peter L. Stanley, Margaret Arbyn, Marc Poljak, Mario Cuzick, Jack Castle, Philip E. Schiller, John T. Markowitz, Lauri E. Fisher, William A. Canfell, Karen Denny, Lynette A. Franco, Eduardo L. Steben, Marc Kane, Mark A. Schiffman, Mark Meijer, Chris J. L. M. Sankaranarayanan, Rengaswamy Castellsague, Xavier Kim, Jane J. Brotons, Maria Alemanya, Laia Albero, Ginesa Diaz, Mireia de Sanjose, Silvia CA ICO Monograph Comprehensive Contro TI Comprehensive Control of Human Papillomavirus Infections and Related Diseases SO VACCINE LA English DT Review DE HPV; Cervical cancer; Anal cancer; Penile cancer; Vaginal cancer; Vulvar cancer; Oropharyngeal cancer; Screening; HPV vaccination; HPV testing; Prevention ID CERVICAL-CANCER; PREVENTION; COUNTRIES; VACCINES; WORLD AB Infection with human papillomavirus (HPV) is recognized as one of the major causes of infection-related cancer worldwide, as well as the causal factor in other diseases. Strong evidence for a causal etiology with HPV has been stated by the International Agency for Research on Cancer for cancers of the cervix uteri, penis, vulva, vagina, anus and oropharynx (including base of the tongue and tonsils). Of the estimated 12.7 million new cancers occurring in 2008 worldwide, 4.8% were attributable to HPV infection, with substantially higher incidence and mortality rates seen in developing versus developed countries. In recent years, we have gained tremendous knowledge about HPVs and their interactions with host cells, tissues and the immune system; have validated and implemented strategies for safe and efficacious prophylactic vaccination against HPV infections; have developed increasingly sensitive and specific molecular diagnostic tools for HPV detection for use in cervical cancer screening; and have substantially increased global awareness of HPV and its many associated diseases in women, men, and children. While these achievements exemplify the success of biomedical research in generating important public health interventions, they also generate new and daunting challenges: costs of HPV prevention and medical care, the implementation of what is technically possible, socio-political resistance to prevention opportunities, and the very wide ranges of national economic capabilities and health care systems. Gains and challenges faced in the quest for comprehensive control of HPV infection and HPV-related cancers and other disease are summarized in this review. The information presented may be viewed in terms of a reframed paradigm of prevention of cervical cancer and other HPV-related diseases that will include strategic combinations of at least four major components: 1) routine introduction of HPV vaccines to women in all countries, 2) extension and simplification of existing screening programs using HPV-based technology, 3) extension of adapted screening programs to developing populations, and 4) consideration of the broader spectrum of cancers and other diseases preventable by HPV vaccination in women, as well as in men. Despite the huge advances already achieved, there must be ongoing efforts including international advocacy to achieve widespread-optimally universal-implementation of HPV prevention strategies in both developed and developing countries. This article summarizes information from the chapters presented in a special ICO Monograph 'Comprehensive Control of HPV Infections and Related Diseases' Vaccine Volume 30, Supplement 5, 2012. Additional details on each subtopic and full information regarding the supporting literature references may be found in the original chapters. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Bosch, F. Xavier; Castellsague, Xavier; Brotons, Maria; Alemanya, Laia; Albero, Ginesa; Diaz, Mireia; de Sanjose, Silvia] IDIBELL, Inst Catala Oncol Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. [Broker, Thomas R.] Univ Alabama Birmingham, Birmingham, AL USA. [Forman, David] Int Agcy Res Canc, Sect Canc Informat, F-69372 Lyon, France. [Moscicki, Anna-Barbara] Univ Calif San Francisco, Dept Pediat, Div Adolescent Med, San Francisco, CA USA. [Gillison, Maura L.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Doorbar, John] Natl Inst Med Res, Div Virol, London NW7 1AA, England. [Stern, Peter L.] Univ Manchester, Paterson Inst Canc Res, Manchester, Lancs, England. [Stanley, Margaret] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Arbyn, Marc] Sci Inst Publ Hlth, Canc Epidemiol Unit, Brussels, Belgium. [Arbyn, Marc] Univ Antwerp, Lab Cell Biol & Histol, B-2020 Antwerp, Belgium. [Poljak, Mario] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia. [Cuzick, Jack] Queen Mary Univ London, Wolfson Inst Prevent Med, London, England. [Castle, Philip E.] Global Canc Initiat, Chestertown, MD USA. [Schiller, John T.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Markowitz, Lauri E.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. [Fisher, William A.] Univ Western Ontario, Dept Psychol, Social Sci Ctr, London, ON, Canada. [Fisher, William A.] Univ Western Ontario, Dept Obstet & Gynaecol, Social Sci Ctr, London, ON, Canada. [Canfell, Karen] Univ NSW, Prince Wales Clin Sch, Lowy Canc Res Ctr, Sydney, NSW, Australia. [Canfell, Karen] NSW Canc Council, Canc Epidemiol Res Unit, Sydney, NSW, Australia. [Denny, Lynette A.] Univ Cape Town, Dept Obstet & Gynaecol, Groote Schuur Hosp, Cape Town, South Africa. [Denny, Lynette A.] Univ Cape Town, Inst Infect Dis & Mol Med, Groote Schuur Hosp, Cape Town, South Africa. [Franco, Eduardo L.] McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada. [Steben, Marc] Inst Natl Sante Publ Quebec, Montreal, PQ, Canada. [Schiffman, Mark] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Meijer, Chris J. L. M.] Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands. [Sankaranarayanan, Rengaswamy] Int Agcy Res Canc, Screening Grp, F-69372 Lyon, France. [Castellsague, Xavier; Alemanya, Laia; Albero, Ginesa; de Sanjose, Silvia] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain. [Kim, Jane J.] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Hlth Decis Sci, Boston, MA 02115 USA. RP Bosch, FX (reprint author), IDIBELL, Inst Catala Oncol Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Barcelona, Spain. EM admincerp@iconcologia.net RI Castellsague Pique, Xavier/N-5795-2014; de Sanjose Llongueras, Silvia/H-6339-2014; BOSCH JOSE, FRANCESC XAVIER/J-6339-2012; DIAZ SANCHIS, MIREIA/H-6335-2014; Albero, Ginesa/G-7248-2015; OI Castellsague Pique, Xavier/0000-0002-0802-3595; BOSCH JOSE, FRANCESC XAVIER/0000-0002-7172-3412; Albero, Ginesa/0000-0002-9400-1914; Franco, Eduardo/0000-0002-4409-8084 FU European Commission [HEALTH-F3-2010-242061, HEALTH-F2-2011-282562]; Instituto de Salud Carlos III (Spanish Government) [FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03110, RTIC RD06/0020/0095, RD12/0036/0056, CIBERESP]; Agenda de Gestio d'Ajuts Universitaris i de Recerca - Generalitat de Catalunya (Catalonian Government) [AGAUR 2005SGR00695, AGAUR 2009SGR126]; USPHS/NIH/National Cancer Institute [CA36200, CA83679]; US Public Health Service (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) [R37 CA51323]; National Institute of AIDS and Infectious Disease [RC1 AI86051]; UK Medical Research Council [MC_U117584278]; European Commission through PREHDICT [242061]; European Commission through HPV AHEAD Network [FP7-HEALTH-2011-282562]; Belgian Foundation Against Cancer (Brussels, Belgium); International Agency for Research on Cancer (Lyon, France); Cancer Research UK [A10404]; National Health and Medical Research Council, Australia [CDF APP1007994, 1007518]; non-commercial government and academic consulting agreements in Australia, New Zealand; non-commercial government and academic consulting agreements in Australia, New Zealand, UK; Cancer Council NSW, Australia; Bill and Melinda Gates Foundation, USA [35537]; U.S. National Cancer Institute [U54 CA164336, R01 CA160744-01A1]; Bill and Melinda Gates Foundation [30505] FX The work was partially supported by public grants from the European Commission (7th Framework Programme grants HEALTH-F3-2010-242061, PREHDICT and HEALTH-F2-2011-282562, HPV AHEAD), from the Instituto de Salud Carlos III (Spanish Government) (grants FIS PI08/1535, FIS PI10/02995, FIS PI11/02090, FIS PI11/02096, FIS PI11/02104, RCESP C03/09, RTICESP C03110, RTIC RD06/0020/0095, RD12/0036/0056 and CIBERESP) and from the Agenda de Gestio d'Ajuts Universitaris i de Recerca - Generalitat de Catalunya (Catalonian Government) (grants AGAUR 2005SGR00695 and AGAUR 2009SGR126), who had no role in data collection, analysis or interpretation of results. Thomas R. Broker receives research support from the USPHS/NIH/National Cancer Institute (grants "Human Papillomavirus Gene Expression" CA36200 and "Mechanisms of Human Papillomavirus DNA Replication" CA83679). Anna-Barbara Moscicki's work is supported by US Public Health Service grant R37 CA51323 (National Cancer Institute, National Institutes of Health, Department of Health and Human Services) and National Institute of AIDS and Infectious Disease RC1 AI86051. John Doorbar is funded by the UK Medical Research Council through program grant MC_U117584278 (Molecular Biology of Human Papillomavirus Infection). Marc Arbyn received financial support from: (1) the 7th Framework Programme of DG Research of the European Commission through the PREHDICT project (grant No. 242061, coordinated by the Vrije Universiteit Amsterdam, the Netherlands) and through the HPV AHEAD Network (FP7-HEALTH-2011-282562); (2) the Belgian Foundation Against Cancer (Brussels, Belgium); and (3) the International Agency for Research on Cancer (Lyon, France). Jack Cuzick was supported in part by Cancer Research UK programme grant A10404. Karen Canfell is supported by grants from the National Health and Medical Research Council, Australia (CDF APP1007994 and Project Grant #1007518), by non-commercial government and academic consulting agreements in Australia, New Zealand and the UK, and by Cancer Council NSW, Australia. Lynette A. Denny was partially supported by Bill and Melinda Gates Foundation, USA (35537). The work of Chris J.L.M. Meijer received support via the 7th Framework Programme of DG Research of the European commission through the PREHDICT project (grant 242061, coordinated via the Vrije Universiteit Amsterdam). Jane J. Kim is supported in part by grants from the U.S. National Cancer Institute (U54 CA164336, R01 CA160744-01A1) and the Bill and Melinda Gates Foundation (30505) for modeling of HPV and cervical cancer in developing countries. NR 20 TC 0 Z9 0 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 29 PY 2013 VL 31 SU 5 BP F1 EP F31 DI 10.1016/j.vaccine.2013.10.001 PG 31 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289LQ UT WOS:000329684400003 PM 24331745 ER PT J AU Averhoff, F Kolwaite, A Ward, JW AF Averhoff, Francisco Kolwaite, Amy Ward, John W. TI The role of the GAVI Alliance in improving childhood hepatitis B vaccination in China: Successes, lessons learned, and future global challenges SO VACCINE LA English DT Editorial Material ID MORTALITY; DISEASE; BURDEN; VIRUS; DEATH C1 [Averhoff, Francisco; Kolwaite, Amy; Ward, John W.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. [Kolwaite, Amy] Ctr Dis Control & Prevent, Sci Educ & Profess Dev Program Off, Atlanta, GA 30329 USA. RP Averhoff, F (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. EM fma0@cdc.gov NR 20 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J5 EP J7 DI 10.1016/j.vaccine.2013.04.022 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400004 PM 23623862 ER PT J AU Cui, FQ Drobeniuc, J Hadler, SC Hutin, YJ Ma, FB Wiersma, S Wang, FZ Wu, J Zheng, H Zhou, LW Zuo, SY AF Cui, Fuqiang Drobeniuc, Jan Hadler, Stephen C. Hutin, Yvan J. Ma, Fubao Wiersma, Steve Wang, Fuzhen Wu, Jiang Zheng, Hui Zhou, Liwei Zuo, Shuyan TI Review of hepatitis B surveillance in China: Improving information to frame future directions in prevention and control SO VACCINE LA English DT Review DE Hepatitis B; Surveillance evaluation; China; Laboratory diagnosis ID CHILDREN; ANTIGEN; TAIWAN AB Background: As the WHO verified that China reached the target of 1% prevalence of chronic hepatitis B infection among children targeted by universal hepatitis B immunization of newborns, the country considered new options for hepatitis B prevention and control. We reviewed hepatitis B surveillance in the broader context of viral hepatitis surveillance to propose recommendations to improve the system. Methods: We described surveillance for viral hepatitis in China with a specific focus on hepatitis B. We assessed critical attributes of the system, including data quality, predictive positive value and usefulness. Results: While remarkable progress in hepatitis B immunization of infants and children has likely almost eliminated transmission in younger age groups, reported rates of hepatitis B increased steadily in China between 1990 and 2008, probably because of a failure to distinguish acute from chronic infections. Elements that prevented a clearer separation between acute and chronic cases included (1) missed opportunity to report cases accurately among clinicians, (2) low availability and use of tests to detect IgM against the hepatitis B core antigen (IgM anti-HBc) and (3) lack of systems to sort, manage and analyze surveillance data. Conclusions: To improve hepatitis B surveillance, China may consider (1) training clinicians to diagnose acute cases and to use IgM anti-HBc to confirm them, (2) improving access and use of validated IgM anti-HBc tests and (3) developing data management and analysis techniques that sort out acute from chronic cases. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Cui, Fuqiang; Wang, Fuzhen; Zheng, Hui] China Ctr Dis Control CDC, Beijing, Peoples R China. [Drobeniuc, Jan] Ctr Dis Control & Prevent, Hepatitis Div, Atlanta, GA USA. [Hadler, Stephen C.; Hutin, Yvan J.; Zuo, Shuyan] WHO, China Country Off, Beijing, Peoples R China. [Ma, Fubao] Jiangsu Ctr Dis Control CDC, Nanjing, Jiangsu, Peoples R China. [Wiersma, Steve] World Hlth Org Headquarters, Geneva, Switzerland. [Wu, Jiang] Beijing Ctr Dis Control CDC, Beijing, Peoples R China. [Zhou, Liwei] Ningxia Ctr Dis Control CDC, Yinchuan, Peoples R China. RP Hutin, YJ (reprint author), WHO, China Country Off, Beijing, Peoples R China. EM yvan.hutin@ecdc.europa.eu FU United States Centers for Disease Control and Prevention; Zeshan Foundation (Hong Kong); WHO FX We are grateful to Alicia Barrasa, Erika Duffel, Michael Edelstein, Dale Hu, Lance Rodewald and Nicole Seguy for critical comments on the manuscript. This work benefited from funding support from the United States Centers for Disease Control and Prevention, from the Zeshan Foundation (Hong Kong) and from the WHO. NR 16 TC 1 Z9 1 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J79 EP J84 DI 10.1016/j.vaccine.2013.05.054 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400016 PM 23770336 ER PT J AU Cui, FQ Liang, XF Gong, XH Chen, YS Wang, FZ Zheng, H Wu, ZH Miao, N Hadler, SC Hutin, YJ Luo, HM Yang, WZ AF Cui, Fuqiang Liang, Xiaofeng Gong, Xiaohong Chen, Yuansheng Wang, Fuzhen Zheng, Hui Wu, Zhenhua Miao, Ning Hadler, Stephen C. Hutin, Yvan J. Luo, Huiming Yang, Weizhong TI Preventing hepatitis B though universal vaccination: Reduction of inequalities through the GAVI China project SO VACCINE LA English DT Article ID HEALTH; COVERAGE; EQUITY; PROGRESS AB Objective: In order to measure hepatitis B coverage and progress in equality with respect to protection against hepatitis B in poverty-affected areas funded by the Global Alliance on Vaccine and Immunization project funded in poverty-affected counties. Methods: We reviewed routinely reported coverage data and conducted a national stratified, validation, cross-sectional survey in October 2010, according to WHO recommended sampling method. First, we stratified China into three regions (Eastern, Central and Western) based on economic criteria. Second, in each region, we selected eight counties with a probability proportional to population size. Third, in each selected county, we selected (a) 10 townships at random among the list of townships of the county. Results: We visited 244 townships as part of the final evaluation (71 in the East, 86 in the Center and 87 in the West). Overall, in these 244 townships, surveyed TBD coverage increased from 60% in 2002 to 91% in 2009 and surveyed three dose of hepatitis B vaccine coverage increased from 71% in 2002 to 93% in 2009. Overall, in the GAVI supported areas, the HepB3/DTP3 ratio increased from 57% in 2002 to 94% in 2009. Conclusion: Pro-poor GAVI approach was an effective way to reduce inequity among children through provision of free vaccination. When vaccine and AD syringes were provided for free, they closed the gap between Eastern and Western regions and between the rich and the poor. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Cui, Fuqiang; Liang, Xiaofeng; Gong, Xiaohong; Chen, Yuansheng; Wang, Fuzhen; Zheng, Hui; Wu, Zhenhua; Miao, Ning; Luo, Huiming; Yang, Weizhong] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Hadler, Stephen C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hutin, Yvan J.] World Hlth Org Off China, Beijing, Peoples R China. RP Yang, WZ (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. EM Yangwz@chinacdc.cn NR 34 TC 7 Z9 8 U1 1 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J29 EP J35 DI 10.1016/j.vaccine.2012.07.048 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400008 PM 24331017 ER PT J AU Cui, FQ Luo, HM Wang, FZ Zheng, H Gong, XH Chen, YS Wu, ZH Miao, N Kane, M Hennessey, K Hadler, SC Hutin, YJ Liang, XF Yang, WZ AF Cui, Fuqiang Luo, Huiming Wang, Fuzhen Zheng, Hui Gong, Xiaohong Chen, Yuansheng Wu, Zhenhua Miao, Ning Kane, Mark Hennessey, Karen Hadler, Stephen C. Hutin, Yvan J. Liang, Xiaofeng Yang, Weizhong TI Evaluation of policies and practices to prevent mother to child transmission of hepatitis B virus in China: Results from China GAVI project final evaluation SO VACCINE LA English DT Article DE Hepatitis B; Transmission; GAVI; Project; Evaluation ID NEWBORN-INFANTS; UNITED-STATES; VACCINATION; IMMUNIZATION; INFECTION; STRATEGY; IMPACT AB Background: Mother to Child Transmission (MTCT) has remained a leading cause of HBV infection in China, accounting for 40% of total infections. Providing hepatitis B vaccine (HepB) to all infants within 24 h of birth (Timely Birth Dose, TBD), and subsequent completion of at least 3 vaccine doses is key to preventing perinatal HBV infection. In 2002, with the financial support of the Global Alliance on Vaccine and Immunization (GAVI) targeted to Western region and 223 poverty-affected counties in Central region, hepatitis B vaccine was provided for free. In 2010, we evaluated the China GAVI project in terms of its activities to prevent perinatal infections. Objective: The objectives of the evaluation were to (1) measure achievements in the China GAVI project in terms of TBD coverage, and (2) describe practices for HBsAg screening of pregnant women and HBIG use outside the GAVI China project. Methods: We used the methods recommended by WHO to select a cluster sample of health care facilities for the purpose of an injection safety assessment. We stratified China into three regions based on economic criteria, and selected eight counties with a probability proportional to population size in each region. In each selected county, we selected (a) 10 townships at random among the list of townships of the county and (b) the one county level hospital. In each hospital, we abstracted 2002 through 2009 records to collect information regarding birth cohorts, hospitals deliveries, vaccine management, hepatitis B vaccination delivery, HBsAg screening practices and results, and HBIG administration. In addition, in all hospitals, we abstracted records regarding the delivery of TBD. Results: We visited 244 facilities in the three regions, including 24 county hospitals and 220 township hospitals. We reviewed 837,409 birth summary records, 699,249 for infants born at county or township hospitals. Hospital delivery rates increased from 58% in 2002 to 93% in 2009. Surveyed TBD coverage increased from 60% in 2002 to 91% in 2009 (+31%). Surveyed TBD coverage among children born in hospitals increased from 73% in 2002 to 98% in 2009. Between 2002 and 2009, the proportion of pregnant women screened for HBsAg increased from 64% in 2002 to 85% in 2009. In 2009, the proportion of infants born to women screened and found to be HBsAg positive who did not receive any immunization within 24 h after birth ranged from 0% to 0.7% across regions. Conclusions: Increased availability of hepatitis B vaccine, along with efforts to improve hospital deliveries, increased TBD coverage in China. This decreased perinatal HBV transmission and will reduce disease burden in the future. Screening for HBsAg to guide HBIG administration has begun, but with heterogeneous immuno-prophylaxis practices and a poor system for follow up. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Cui, Fuqiang; Luo, Huiming; Wang, Fuzhen; Zheng, Hui; Gong, Xiaohong; Chen, Yuansheng; Wu, Zhenhua; Miao, Ning; Liang, Xiaofeng; Yang, Weizhong] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Hennessey, Karen] WHO, Manila, Philippines. [Hadler, Stephen C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hutin, Yvan J.] World Hlth Org Off China, Beijing, Peoples R China. RP Yang, WZ (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. EM Yangwz@chinacdc.cn NR 26 TC 10 Z9 11 U1 2 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J36 EP J42 DI 10.1016/j.vaccine.2012.11.061 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400009 PM 24331019 ER PT J AU Hadler, SC Cui, FQ Averhoff, F Taylor, T Wang, FZ Li, L Liang, XF Yang, WZ AF Hadler, Stephen C. Cui Fuqiang Averhoff, Francisco Taylor, Thomas Wang Fuzhen Li, Li Liang Xiaofeng Yang Weizhong TI The impact of hepatitis B vaccine in China and in the China GAVI Project SO VACCINE LA English DT Article DE Hepatitis B; Surveillance evaluation; China; Laboratory diagnosis ID C VIRUS-INFECTIONS; HEPATOCELLULAR-CARCINOMA; LIVER-CANCER; CHILDREN; POPULATION; PROGRAM; TAIWAN AB The China GAVI Project (CGP) was initiated in 2002 to provide hepatitis B (HB) vaccine to infants born in the less developed areas of China including the Western provinces and poverty counties of Middle provinces, to prevent the consequences of hepatitis B virus infection. By 2009, the project areas had raised coverage of 3 doses of HB vaccine and timely birth doses to almost 90% among infants, comparable to those in wealthier Eastern provinces, and reduced HBV prevalence to <1% among children in these areas. We estimated the impact in disease prevented by HB vaccine in China between 1992, when the vaccine was routinely recommended, and 2009, and in CGP areas for the years 2003-2009, when the CGP was active. A published model was used to estimate the burden of chronic and acute HBV infection and death prevented due to HB vaccination in China and the CGP areas using data from national serosurveys in China in 1992 and 2006, and HB vaccine coverage from surveys in 2004, 2006 and 2010. We used sigmoid modeling to estimate vaccine coverage nationally, regionally, and CGP areas. We also estimated the incremental impact of the CGP on HB vaccine coverage in those underserved areas. Our findings suggest that between 1992 and 2009, HB vaccination in China has prevented 24 million chronic HBV infections and 4.3 million future deaths due to cirrhosis, hepatocellular carcinoma and acute hepatitis. During the CGP between 2003 and 2009, an estimated 3.8 million chronic HBV infections and 680,000 deaths were prevented in CGP areas. We found that the CGP funding increased HB vaccine coverage in project areas by 4-15% for HB3 and 4-27% for timely birth dose beyond the coverage expected without the CGP. The CGP represents a highly successful public health collaboration between the national government and international partners. Published by Elsevier Ltd. C1 [Hadler, Stephen C.; Taylor, Thomas] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Infect, Div Bacterial Dis, Atlanta, GA USA. [Cui Fuqiang; Wang Fuzhen; Li, Li; Liang Xiaofeng; Yang Weizhong] China Ctr Dis Control & Prevent, Natl Immunizat Program, Beijing, Peoples R China. [Averhoff, Francisco] Ctr Dis Control & Prevent, Natl Ctr HIV AIDs Hepatitis Sexually Transmitted, Div Viral Hepatitis, Atlanta, GA USA. RP Hadler, SC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Infect, Div Bacterial Dis, Atlanta, GA USA. EM sch1@cdc.gov NR 24 TC 11 Z9 13 U1 4 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J66 EP J72 DI 10.1016/j.vaccine.2013.03.043 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400014 PM 24331023 ER PT J AU Kane, MA Hadler, SC Lee, L Shapiro, CN Cui, F Wang, X Kumar, R AF Kane, M. A. Hadler, S. C. Lee, L. Shapiro, C. N. Cui, F. Wang, X. Kumar, R. TI The inception, achievements, and implications of the China GAVI Alliance Project on Hepatitis B Immunization SO VACCINE LA English DT Review ID NEWBORN-INFANTS; TRANSMISSION; VACCINATION AB The China GAVI Hepatitis B Immunization Project was initiated in 2002 with the signing of a Memorandum of Understanding between GAVI and the Government of China. The Project was one of the three (China, India, and Indonesia) GAVI-initiated special projects done to support countries too large to receive full GAVI support for hepatitis B vaccine and safe injections. The Project in China was designed by the Chinese Government and partners to deliver free hepatitis B vaccine and safe injections to all newborns in the 12 Western Provinces and Poverty Counties in 10 Provinces of Central China (1301 Counties with approximately 5.6 million births per year), eliminating the gap in immunization coverage between wealthier and poorer regions of China. The project budget (USD 76 million) was equally shared by GAVI and the Chinese Government. Initially planned for 5 years, two no cost extensions extended the project to 2011. Although China produced hepatitis B vaccine, before the project the vaccine was sold to parents who were also charged a "user fee" for the syringe and vaccine administration. Basic Expanded Program on Immunization (EPI) vaccines such as BCG, DTP, Polio, and measles vaccines were provided free to parents, although they were charged a user fee. Vaccines were sold by China CDC Offices at provincial, prefecture, county level and township hospitals, and village doctors received a substantial portion of their income from the sale of hepatitis B and other vaccines. The result of charging for hepatitis B vaccine was that coverage was relatively high in Eastern and wealthier counties in Central China (similar to 80-90%), but was much lower (similar to 40%) in Western China and Poverty Counties where parents could not afford the vaccine. The Project was administered by the China MOH and China CDC EPI program, and two Project Co-managers, one from the Chinese Government and the other an international assignee, were chosen. The project had an oversight Operational Advisory Group composed of the Chinese Government, WHO, UNICEF, and GAVI. The initial targets of the project as delineated in the initial MOU for the Project areas (HepB3 coverage will reach 85% at the county level, >75% of newborns at the county level will receive the first dose of hepatitis B within 24 h of birth, and all immunization injections will be with auto disable [AD] syringes) were substantially exceeded. The differential in vaccine coverage between wealthier and poorer parts of China was eliminated contributing to a great improvement inequity. With additional contributions of the Chinese Government the Project was accomplished substantially under budget allowing for additional catch up immunization of children under 15 years of age. More than 5 million health workers were trained in how to deliver hepatitis B vaccine, timely birth dose (TBD), and safe injections, and public awareness of hepatitis B and its prevention rose significantly. TBD coverage was expedited by concurrent efforts to have women deliver in township clinics and district hospitals instead of at home. The effective management of the Project, with a Project office sitting within the China EPI and an Operational Advisory Group for oversight, could serve as a model for other GAVI projects worldwide. Most importantly, the carrier rate in Chinese children less than 5 years of age has fallen to 1%, from a level of 10% before the inception of the Project. Liver cancer, one of the major cancer killers in China (250,000-300,000 annual estimated deaths), will dramatically decline as immunized cohorts of Chinese children age. While hepatitis C and non-alcoholic liver disease also exist in China and can lead to liver cancer and cirrhosis, the majority of liver disease in China is hepatitis B related and therefore preventable. The authors believe that China's success in preventing hepatitis B is one of the greatest public health achievements of the 21st century. Work remains to be done in several key areas. There are still pockets of home births in rural provinces where a TBD is difficult to deliver, and China is strengthening its policy of screening pregnant women for HBsAg and delivering HBIG plus vaccine to newborns of HBV carrier mothers. Approximately 10% of the adult population of China remain chronic carriers of hepatitis B virus and cannot be helped by the vaccine, so prevention of liver cancer and cirrhosis in those groups remains a future challenge for China. (C) 2013 Published by Elsevier Ltd. C1 [Hadler, S. C.] NCIRD, Div Bacterial Dis, Ctr Dis Control & Prevent, Atlanta, GA USA. [Shapiro, C. N.] US Dept HHS, Off Global Affairs, Washington, DC 20201 USA. [Cui, F.] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Wang, X.] WHO, Reg Off Western Pacific Manila, Manila, Philippines. [Kumar, R.] GAVI Alliance, Geneva, Switzerland. EM mark.a.kane@gmail.com NR 25 TC 6 Z9 7 U1 1 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J15 EP J20 DI 10.1016/j.vaccine.2013.03.045 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400006 PM 24331015 ER PT J AU Liang, XF Cui, FQ Hadler, S Wang, XJ Luo, HM Chen, YS Kane, M Shapiro, C Yang, WZ Wang, Y AF Liang, Xiaofeng Cui, Fuqiang Hadler, Stephen Wang, Xiaojun Luo, Huiming Chen, Yuansheng Kane, Mark Shapiro, Craig Yang, Weizhong Wang, Yu TI Origins, design and implementation of the China GAVI project SO VACCINE LA English DT Review DE Hepatitis B; Vaccine; Project ID HEPATITIS-B-VIRUS; VACCINATION AB China received GAVI support for hepatitis B vaccination in 2001 because of high disease burden and strong government will to protect infants at risk. The China/GAVI project, implemented since 2002, was funded 50% by GAVI and 50% by the Government of China. The purpose of the project was to increase coverage of hepatitis B vaccine through a pro-poor approach targeting all counties of the 12 Western provinces and poverty counties of the 10 Central provinces, to accelerate integration of hepatitis B vaccine into routine immunization, and assure immunization injection safety. The mechanism of internal coordination among multiple government entities and international cooperation was established and comprehensive strategies were used to improve vaccine coverage and injection safety. After 8 years of implementation, 193,000 health care workers in 118,316 health care facilities participated in the project, mostly at the township hospitals level (55,051) and in community centres (104,547). Through the China GAVI project, the 85% HepB3 coverage goal was reached in 98% of GAVI China project counties, the 75% timely birth dose (TBD) coverage goal was reached in 80% of GAVI project counties, and AD syringes were introduced into 100% of GAVI-supported areas. Additionally, the GAVI project was instrumental in convincing the Chinese Government to sustainably introduce and fully fund HepB vaccine for all newborns in China. The impact of hepB vaccination on HBsAg prevalence was observed throughout China, as HBsAg prevalence (previously similar to 10%) is now less than 1% among children under 5 years of age. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Liang, Xiaofeng; Cui, Fuqiang; Luo, Huiming; Chen, Yuansheng; Yang, Weizhong; Wang, Yu] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Hadler, Stephen; Shapiro, Craig] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kane, Mark] WHO, Western Pacific Reg Off, Manila, Philippines. RP Wang, Y (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. EM Wangyu@chinacdc.cn NR 16 TC 7 Z9 7 U1 3 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J8 EP J14 DI 10.1016/j.vaccine.2012.12.019 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400005 PM 24331025 ER PT J AU Wu, ZH Cui, FQ Chen, YS Miao, N Gong, XH Luo, HM Wang, FZ Zheng, H Kane, M Hadler, SC Hutin, YJ Liang, XF Yang, WZ AF Wu, Zhenhua Cui, Fuqiang Chen, Yuansheng Miao, Ning Gong, Xiaohong Luo, Huiming Wang, Fuzhen Zheng, Hui Kane, Mark Hadler, Stephen C. Hutin, Yvan J. Liang, Xiaofeng Yang, Weizhong TI Evaluation of immunization injection safety in China, 2010: Achievements, future sustainability SO VACCINE LA English DT Article DE Immunization; Injection safety; Evaluation ID UNITED-STATES; HEPATITIS-B AB Objective: The study objectives were to evaluate injection practices in China in the post GAVI project era and provide guidance for policy makers to update national standards for injection practices and further improve vaccination services. Methods: We conducted a national stratified, cross-sectional survey in October 2010, according to WHO recommended sampling methods. First, we stratified China into three regions (Eastern, Central and Western) based on economic criteria. Second, in each region, we selected eight counties with a probability proportional to population size. Third, in each selected county, we selected (a) 10 townships at random among the list of townships of the county and (b) the one county level hospital. Results: With respect to the risk to the patient, we never observed open injection equipment lying around or needles left in the septum of multi-dose vials. We never observed sterilizable injection devices syringes in any of the facilities. The proportion of facilities using sharps containers was highest in the East (85%), intermediate in the West (79%) and lowest in the Central region (56%). In 2009, auto-disable syringes and safety boxes were used in 78% and 79% facilities in GAVI supported areas of the Western region, respectively. Only one facility presented evidence of attempts to re-sterilize disposable injection equipment in the Eastern region. Conclusions: Use of AD syringe and sharps containers increased in vaccination services in China, especially in GAVI supported areas, leading to sustainable progress in terms of elimination of reuse of injection devices. However, risk to patients still existed, including persisting use of standard disposable syringes and attempts to re-use disposable devices. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Wu, Zhenhua; Cui, Fuqiang; Chen, Yuansheng; Miao, Ning; Gong, Xiaohong; Luo, Huiming; Wang, Fuzhen; Zheng, Hui; Liang, Xiaofeng; Yang, Weizhong] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Hadler, Stephen C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hutin, Yvan J.] World Hlth Org Off China, Beijing, Peoples R China. RP Cui, FQ (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. EM Cuifuq@126.com NR 17 TC 2 Z9 2 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J43 EP J48 DI 10.1016/j.vaccine.2012.11.057 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400010 PM 24331020 ER PT J AU Yang, WZ Liang, XF Cui, FQ Li, L Hadler, SC Hutin, YJ Kane, M Wang, Y AF Yang, Weizhong Liang, Xiaofeng Cui, Fuqiang Li, Li Hadler, Stephen C. Hutin, Yvan J. Kane, Mark Wang, Yu TI Key outcomes and addressing remaining challenges-Perspectives from a final evaluation of the China GAVI project SO VACCINE LA English DT Article DE GAVI; Project; Outcomes; Challenges ID HEALTH-CARE WORKERS; HEPATITIS-B; JAPANESE ENCEPHALITIS; COST-EFFECTIVENESS; IMMUNIZATION; VACCINATION; INJURIES; PROGRAM; BURDEN AB During the China GAVI project, implemented between 2002 and 2010, more than 25 million children received hepatitis B vaccine with the support of project, and the vaccine proved to be safe and effective. With careful consideration for project savings, China and GAVI continually adjusted the budget, additionally allowing the project to spend operational funds to support demonstration projects to improve timely birth dose (TBD), conduct training of EPI staff, and to monitor the project impact. Results from the final evaluation indicated the achievement of key outcomes. As a result of government co-investment, human resources at county level engaged in hepatitis B vaccination increased from 29 per county on average in 2002 to 66 in 2009. All project counties funded by the GAVI project use auto-disable syringes for hepatitis B vaccination and other vaccines. Surveyed hepatitis B vaccine coverage increased from 71% in 2002 to 93% in 2009 among infants. The HBsAg prevalence declined from 9.67% in 1992 to 0.96% in 2006 among children under 5 years of age. However, several important issues remain: (1) China still accounts for the largest annual number of perinatal HBV infections (estimated 84,121) in the WHO WPR region; (2) China still lacks a clear national policy for safe injection of vaccines; (3) vaccination of high risk adults and protection of health care workers are still not implemented; (4) hepatitis B surveillance needs to be refined to more accurately monitor acute hepatitis B; and (5) a program for treatment of persons with chronic HBV infection is needed. Recommendations for future hepatitis B control include: using the lessons learned from the China GAVI project for future introductions of new vaccines; addressing unmet needs with a second generation hepatitis B program to reach every infant, including screening mothers, and providing HBIG for infants born to HBsAg positive mothers; expanding vaccination to high risk adults; addressing remaining unsafe injection issues; and improving monitoring of acute hepatitis B. This paper describes findings and discusses perspectives from a final project evaluation, a national stratified validated cross-sectional survey done in October 2010. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Yang, Weizhong; Liang, Xiaofeng; Cui, Fuqiang; Li, Li; Wang, Yu] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Hadler, Stephen C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hutin, Yvan J.] Europe Ctr Dis Control & Prevent, Stockholm, Sweden. RP Wang, Y (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. EM Wangyu@chinacdc.cn NR 30 TC 2 Z9 2 U1 2 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 27 PY 2013 VL 31 SU 9 BP J73 EP J78 DI 10.1016/j.vaccine.2012.09.060 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289MA UT WOS:000329685400015 PM 24331024 ER PT J AU Roberge, RJ Kim, JH Powell, JB Shaffer, RE Ylitalo, CM Sebastian, JM AF Roberge, Raymond J. Kim, Jung-Hyun Powell, Jeffrey B. Shaffer, Ronald E. Ylitalo, Caroline M. Sebastian, John M. TI Impact of Low Filter Resistances on Subjective and Physiological Responses to Filtering Facepiece Respirators SO PLOS ONE LA English DT Article ID HEALTH-CARE WORKERS; BREATHING RESISTANCE; CARBON-DIOXIDE; N95; PERCEPTION; LOADS; APPARATUS; HUMIDITY; DEVICES; HUMANS AB Ten subjects underwent treadmill exercise at 5.6 km/h over one hour while wearing each of three identical appearing, cup-shaped, prototype filtering facepiece respirators that differed only in their filter resistances (3 mm, 6 mm, and 9 mm H2O pressure drop). There were no statistically significant differences between filtering facepiece respirators with respect to impact on physiological parameters (i.e., heart rate, respiratory rate, oxygen saturation, transcutaneous carbon dioxide levels, tympanic membrane temperature), pulmonary function variables (i.e., tidal volume, respiratory rate, volume of carbon dioxide production, oxygen consumption, or ventilation), and subjective ratings (i.e., exertion, thermal comfort, inspiratory effort, expiratory effort and overall breathing comfort). The nominal filter resistances of the prototype filtering facepiece respirators correspond to airflow resistances ranging from 2.1 - 6.6 mm H2O/L/s which are less than, or minimally equivalent to, previously reported values for the normal threshold for detection of inspiratory breathing resistance (6 - 7.6 mm H2O/L/sec). Therefore, filtering facepiece respirators with filter resistances at, or below, this level may not impact the wearer differently physiologically or subjectively from those with filter resistances only slightly above this threshold at low-moderate work rates over one hour. C1 [Roberge, Raymond J.; Kim, Jung-Hyun; Powell, Jeffrey B.; Shaffer, Ronald E.] NIOSH, Technol Res Branch, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. [Ylitalo, Caroline M.; Sebastian, John M.] 3M Co, Personal Safety Div, St Paul, MN 55144 USA. RP Roberge, RJ (reprint author), NIOSH, Technol Res Branch, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov FU National Institute for Occupational Safety and Health (NIOSH); US Centers for Disease Control and Prevention FX This work was supported by internal operating funds from the National Institute for Occupational Safety and Health (NIOSH), part of the US Centers for Disease Control and Prevention. Raymond J. Roberge, Jung-Hyun Kim, Jeffrey B. Powell, and Ronald E. Shaffer are NIOSH employees who were involved in conducting the study, analyzing the results, and preparing the manuscript. NR 44 TC 7 Z9 7 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 27 PY 2013 VL 8 IS 12 AR e84901 DI 10.1371/journal.pone.0084901 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 281RE UT WOS:000329117900117 PM 24386434 ER PT J AU Rey, GU Miao, CR Caidi, H Trivedi, SU Harcourt, JL Tripp, RA Anderson, LJ Haynes, LM AF Rey, Gertrud U. Miao, Congrong Caidi, Hayat Trivedi, Suvang U. Harcourt, Jennifer L. Tripp, Ralph A. Anderson, Larry J. Haynes, Lia M. TI Decrease in Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) Enhanced Disease with RSV G Glycoprotein Peptide Immunization in BALB/c Mice SO PLOS ONE LA English DT Article ID PULMONARY INFLAMMATORY RESPONSE; MESSENGER-RNA EXPRESSION; ATTACHMENT G PROTEIN; SUBSTANCE-P; YOUNG-CHILDREN; T-CELLS; VACCINE; INFECTION; EOSINOPHILIA; IMMUNOGENICITY AB Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI-RSV) vaccine. Since a mAb specific to RSV G protein can reduce pulmonary inflammation and eosinophilia seen after RSV infection of FI-RSV vaccinated mice, we hypothesized that RSV G peptides that induce antibodies with similar reactivity may limit enhanced disease after subunit or other non-live RSV vaccines. In support of this hypothesis, we show that FI-RSV vaccinated mice administered RSV G peptide vaccines had a significant reduction in enhanced disease after RSV challenge. These data support the importance of RSV G during infection to RSV disease pathogenesis and suggest that use of appropriately designed G peptide vaccines to reduce the risk of enhanced disease with non-live RSV vaccines merits further study. C1 [Rey, Gertrud U.; Miao, Congrong; Caidi, Hayat; Trivedi, Suvang U.; Harcourt, Jennifer L.; Haynes, Lia M.] Ctr Dis Control & Prevent CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. [Tripp, Ralph A.] Univ Georgia, Coll Vet Med, Dept Infect Dis, Athens, GA USA. [Anderson, Larry J.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA. [Anderson, Larry J.] Childrens Healthcare Atlanta, Emory Childrens Ctr, Atlanta, GA USA. RP Haynes, LM (reprint author), Ctr Dis Control & Prevent CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. EM loh5@cdc.gov OI Tripp, Ralph/0000-0002-2924-9956 FU appointment to the Research Participation Program at the Centers for Disease Control and Prevention (CDC); National Institutes of Health [5RO1AI06275-03]; Georgia Research Alliance FX This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention (CDC) administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and CDC. G. R. and SUT were ORISE Fellows at the time this study was performed. This research was also supported in part by the National Institutes of Health (5RO1AI06275-03) and through the Georgia Research Alliance to R. T. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 2 Z9 2 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 23 PY 2013 VL 8 IS 12 AR e83075 DI 10.1371/journal.pone.0083075 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 278IG UT WOS:000328882000056 PM 24376637 ER PT J AU Yuen, CM Kurbatova, EV Click, ES Cavanaugh, JS Cegielski, JP AF Yuen, Courtney M. Kurbatova, Ekaterina V. Click, Eleanor S. Cavanaugh, J. Sean Cegielski, J. Peter TI Association between Mycobacterium tuberculosis Complex Phylogenetic Lineage and Acquired Drug Resistance SO PLOS ONE LA English DT Article ID SHORT-COURSE CHEMOTHERAPY; UNITED-STATES; PYRAZINAMIDE; SUSCEPTIBILITY; RELAPSE; METAANALYSIS; GENOTYPE; MUTATION; OUTCOMES; BOVIS AB Background: Development of resistance to antituberculosis drugs during treatment (i.e., acquired resistance) can lead to emergence of resistant strains and consequent poor clinical outcomes. However, it is unknown whether Mycobacterium tuberculosis complex species and lineage affects the likelihood of acquired resistance. Methods: We analyzed data from the U. S. National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service for tuberculosis cases during 2004-2011 with assigned species and lineage and both initial and final drug susceptibility test results. We determined univariate associations between species and lineage of Mycobacterium tuberculosis complex bacteria and acquired resistance to isoniazid, rifamycins, fluoroquinolones, and second-line injectables. We used Poisson regression with backward elimination to generate multivariable models for acquired resistance to isoniazid and rifamycins. Results: M. bovis was independently associated with acquired resistance to isoniazid (adjusted prevalence ratio = 8.46, 95% CI 2.96-24.14) adjusting for HIV status, and with acquired resistance to rifamycins (adjusted prevalence ratio = 4.53, 95% CI 1.29-15.90) adjusting for homelessness, HIV status, initial resistance to isoniazid, site of disease, and administration of therapy. East Asian lineage was associated with acquired resistance to fluoroquinolones (prevalence ratio = 6.10, 95% CI 1.56-23.83). Conclusions: We found an association between mycobacterial species and lineage and acquired drug resistance using U. S. surveillance data. Prospective clinical studies are needed to determine the clinical significance of these findings, including whether rapid genotyping of isolates at the outset of treatment may benefit patient management. C1 [Yuen, Courtney M.; Kurbatova, Ekaterina V.; Click, Eleanor S.; Cavanaugh, J. Sean; Cegielski, J. Peter] US Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div TB Eliminat, Atlanta, GA 30333 USA. RP Kurbatova, EV (reprint author), US Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div TB Eliminat, Atlanta, GA 30333 USA. EM EKurbatova@cdc.gov NR 37 TC 4 Z9 4 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 23 PY 2013 VL 8 IS 12 AR e83006 DI 10.1371/journal.pone.0083006 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 278IG UT WOS:000328882000050 PM 24376623 ER PT J AU Abdulla, S Alonso, P Binka, F Graves, P Greenwood, B Leke, R Malik, E Marsh, K Meek, S Mendis, K Schapira, A Slutsker, L Tanner, M Valecha, N White, N Bosman, A Cibulskis, R D'Souza, B Lynch, M MacDonald, M Mintcheva, R Mnzava, A Newman, R Ringwald, P Szilagyi, Z Wongsrichanalai, C AF Abdulla, Salim Alonso, Pedro Binka, Fred Graves, Patricia Greenwood, Brian Leke, Rose Malik, Elfatih Marsh, Kevin Meek, Sylvia Mendis, Kamini Schapira, Allan Slutsker, Laurence Tanner, Marcel Valecha, Neena White, Nicholas Bosman, Andrea Cibulskis, Richard D'Souza, Bianca Lynch, Michael MacDonald, Michael Mintcheva, Rossitza Mnzava, Abraham Newman, Robert Ringwald, Pascal Szilagyi, Zsofia Wongsrichanalai, Chansuda CA WHO Malaria Policy Advisory Comm TI Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2013 meeting SO MALARIA JOURNAL LA English DT Article DE WHO; Malaria; Policy making; Mosquito control; Pregnancy; Prevention; Sulphadoxine-pyrimethamine; Treatment efficacy; Drug resistance; Surveillance; Elimination; Plasmodium falciparum; Plasmodium vivax AB The Malaria Policy Advisory Committee to the World Health Organization held its fourth meeting in Geneva, Switzerland from 11 to 13 September, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting. Meeting sessions included: recommendations for achieving universal coverage of long-lasting insecticide-treated nets; guidance on estimating the longevity of insecticide-treated nets; improving capacity in entomology and vector control; a review of the latest evidence on intermittent preventive treatment in pregnancy; improving dissemination of Malaria Policy Advisory Committee guidance; updates on the development of the global technical strategy for malaria control and elimination (2016-2025) and the global strategy for control and elimination of Plasmodium vivax; updates from the drug resistance and containment technical expert group, the evidence review group on malaria burden estimation, a consultation on malaria case management indicators, and the constitution of the surveillance, monitoring and evaluation technical expert group; subnational elimination criteria; and consideration for future evidence review groups, including diagnosis in low transmission settings and testing for Glucose-6-Phosphate Dehydrogenase Deficiency. Policy statements, position statements and guidelines that arise from the Malaria Policy Advisory Committee meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme. C1 [Abdulla, Salim] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [Alonso, Pedro] Ctr Int Hlth & Res, Barcelona, Spain. [Binka, Fred] Univ Ghana, Accra, Ghana. [Graves, Patricia] James Cook Univ, Cairns, Australia. [Greenwood, Brian; D'Souza, Bianca] London Sch Hyg & Trop Med, London WC1, England. [Leke, Rose] Univ Yaounde, Yaounde, Cameroon. [Malik, Elfatih] Minist Hlth, Gezira, Sudan. [Marsh, Kevin] Kenya Govt Med Res Ctr, Kilifi, Kenya. [Meek, Sylvia] Malaria Consortium, London, England. [Slutsker, Laurence] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tanner, Marcel] Swiss Trop Publ Hlth Inst, Basel, Switzerland. [Valecha, Neena] Natl Inst Malaria Res, New Delhi, India. [White, Nicholas] Mahidol Univ, Bangkok 10700, Thailand. [Bosman, Andrea; Cibulskis, Richard; D'Souza, Bianca; MacDonald, Michael; Mintcheva, Rossitza; Mnzava, Abraham; Newman, Robert; Ringwald, Pascal; Szilagyi, Zsofia; Wongsrichanalai, Chansuda] WHO Global Malaria Programme, Geneva, Switzerland. RP Abdulla, S (reprint author), WHO, Global Malaria Programme, 20 Ave Appia 27, CH-1211 Geneva, Switzerland. EM mpacgmp@who.int RI Graves, Patricia/J-8691-2014 OI Graves, Patricia/0000-0002-5215-3901 FU Bill & Melinda Gates Foundation; UK Department for International Development (DFID); United States Agency for International Development (USAID) FX The authors gratefully acknowledge the hard work of the many people who contributed to the background documents and other preparations for the MPAC meeting: WHO-GMP staff, in particular Kathryn Andrews, Jane Cunningham, and Lise Riopel; Peter Smith (Chair, ERG MBE) from the London School of Hygiene and Tropical Medicine; and Melanie Renshaw (Chair, VC TEG) from the African Leaders Malaria Alliance. The authors also thank all the MPAC meeting participants and observers for their contributions during the meeting discussions. The MPAC process is supported in part by grants from the Bill & Melinda Gates Foundation, the UK Department for International Development (DFID), and the United States Agency for International Development (USAID) to the WHO Global Malaria Programme. NR 44 TC 1 Z9 1 U1 1 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 20 PY 2013 VL 12 AR 456 DI 10.1186/1475-2875-12-456 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 297HT UT WOS:000330247200001 ER PT J AU Schillie, S Murphy, TV Sawyer, M Ly, K Hughes, E Jiles, R de Perio, MA Reilly, M Byrd, K Ward, JW AF Schillie, Sarah Murphy, Trudy V. Sawyer, Mark Ly, Kathleen Hughes, Elizabeth Jiles, Ruth de Perio, Marie A. Reilly, Meredith Byrd, Kathy Ward, John W. TI CDC Guidance for Evaluating Health-Care Personnel for Hepatitis B Virus Protection and for Administering Postexposure Management SO MMWR RECOMMENDATIONS AND REPORTS LA English DT Article ID DIALYSIS-ASSOCIATED HEPATITIS; IMMUNE SERUM GLOBULIN; UNITED-STATES; VACCINATION COVERAGE; REGISTERED NURSES; VIRAL-HEPATITIS; FINAL REPORT; CONTROLLED TRIAL; BLOOD EXPOSURE; DOUBLE-BLIND AB This report contains CDC guidance that augments the 2011 recommendations of the Advisory Committee on Immunization Practices (ACIP) for evaluating hepatitis B protection among health-care personnel (HCP) and administering post-exposure prophylaxis. Explicit guidance is provided for persons working, training, or volunteering in health-care settings who have documented hepatitis B (HepB) vaccination years before hire or matriculation (e. g., when HepB vaccination was received as part of routine infant [recommended since 1991] or catch-up adolescent [recommended since 1995] vaccination). In the United States, 2,890 cases of acute hepatitis B were reported to CDC in 2011, and an estimated 18,800 new cases of hepatitis B occurred after accounting for underreporting of cases and asymptomatic infection. Although the rate of acute hepatitis B virus (HBV) infections have declined approximately 89% during 1990-2011, from 8.5 to 0.9 cases per 100,000 population in the United States, the risk for occupationally acquired HBV among HCP persists, largely from exposures to patients with chronic HBV infection. ACIP recommends HepB vaccination for unvaccinated or incompletely vaccinated HCP with reasonably anticipated risk for blood or body fluid exposure. ACIP also recommends that vaccinated HCP receive postvaccination serologic testing (antibody to hepatitis B surface antigen [anti-HBs]) 1-2 months after the final dose of vaccine is administered (CDC. Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2011;60 [No. RR-7]). Increasing numbers of HCP have received routine HepB vaccination either as infants (recommended since 1991) or as catch-up vaccination (recommended since 1995) in adolescence. HepB vaccination results in protective anti-HBs responses among approximately 95% of healthy-term infants. Certain institutions test vaccinated HCP by measuring anti-HBs upon hire or matriculation, even when anti-HBs testing occurs greater than 2 months after vaccination. This guidance can assist clinicians, occupational health and student health providers, infection-control specialists, hospital and health-care training program administrators, and others in selection of an approach for assessing HBV protection for vaccinated HCP. This report emphasizes the importance of administering HepB vaccination for all HCP, provides explicit guidance for evaluating hepatitis B protection among previously vaccinated HCP (particularly those who were vaccinated in infancy or adolescence), and clarifies recommendations for postexposure management of HCP exposed to blood or body fluids. C1 [Sawyer, Mark] Univ Calif San Diego, San Diego, CA 92103 USA. [de Perio, Marie A.] NIOSH, CDC, Washington, DC 20201 USA. [Reilly, Meredith] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD 21218 USA. EM sschillie@cdc.gov RI Nace, David/D-2638-2014 FU Merck; Sanofi; Pfizer pharmaceutical companies; MedImmune FX The developers of these guidelines wish to disclose that they have no financial interests or other relationships with the manufacturers of commercial products or suppliers of commercial services related to vaccines including any related to hepatitis B vaccines, with the following exceptions: David Weber, MD, wishes to disclose that he served as a consultant and on a speakers' bureau, whether paid or unpaid (e.g., travel related reimbursement, honoraria), for the following vaccine manufacturers: Merck, Sanofi, and Pfizer pharmaceutical companies. Amy B. Middleman, MD, also wishes to disclose that she received grant funding from the following pharmaceutical companies: MedImmune, Sanofi, and Merck. NR 89 TC 30 Z9 31 U1 0 U2 4 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 1057-5987 EI 1545-8601 J9 MMWR RECOMM REP JI MMWR Recomm. Rep. PD DEC 20 PY 2013 VL 62 IS 10 BP 1 EP 19 PG 19 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 290KL UT WOS:000329755000001 PM 24352112 ER PT J AU Carriquiry, A Moshfegh, AJ Steinfeldt, LC Cogswell, ME Loustalot, F Zhang, ZF Yang, QH Tian, N AF Carriquiry, Alicia Moshfegh, Alanna J. Steinfeldt, Lois C. Cogswell, Mary E. Loustalot, Fleetwood Zhang, Zefeng Yang, Quanhe Tian, Niu TI Trends in the Prevalence of Excess Dietary Sodium Intake - United States, 2003-2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CONSUMPTION C1 [Carriquiry, Alicia] Iowa State Univ, Ames, IA 50011 USA. [Tian, Niu] CDC, Atlanta, GA 30333 USA. RP Tian, N (reprint author), CDC, Atlanta, GA 30333 USA. EM vii9@cdc.gov NR 9 TC 20 Z9 20 U1 0 U2 4 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 20 PY 2013 VL 62 IS 50 BP 1021 EP 1025 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 278AX UT WOS:000328861500001 ER PT J AU Teague, NS Grigg, SS Peterson, JC Gomez, GA Talkington, DF AF Teague, Nathan S. Grigg, Stephanie S. Peterson, Jasmine C. Gomez, Gerardo A. Talkington, Deborah F. TI Outbreak of Staphylococcal Food Poisoning from a Military Unit Lunch Party - United States, July 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID AUREUS C1 [Gomez, Gerardo A.; Talkington, Deborah F.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM nathaniel.teague@afrims.org; goe4@cdc.gov NR 7 TC 2 Z9 2 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 20 PY 2013 VL 62 IS 50 BP 1026 EP 1028 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 278AX UT WOS:000328861500002 ER PT J AU Foley, C Harvey, E Bidol, SA Henderson, T Njord, R DeSalvo, T Haupt, T Mba-Jonas, A Bailey, C Bopp, C Bosch, SA Gerner-Smidt, P Mody, RK Nguyen, TA Strockbine, N Tauxe, RV AF Foley, Catherine Harvey, Emily Bidol, Sally A. Henderson, Tiffany Njord, Rebecca DeSalvo, Traci Haupt, Thomas Mba-Jonas, Adamma Bailey, Chris Bopp, Cheryl Bosch, Stacey A. Gerner-Smidt, Peter Mody, Rajal K. Thai-An Nguyen Strockbine, Nancy Tauxe, Robert V. TI Outbreak of Escherichia coli O104:H4 Infections Associated with Sprout Consumption - Europe and North America, May-July 2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Harvey, Emily] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA. [Mba-Jonas, Adamma] US FDA, Dept Epidemiol, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA. [Bailey, Chris; Bopp, Cheryl; Bosch, Stacey A.; Gerner-Smidt, Peter; Mody, Rajal K.; Thai-An Nguyen; Strockbine, Nancy; Tauxe, Robert V.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Mba-Jonas, A (reprint author), US FDA, Dept Epidemiol, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA. EM adamma.mba-jonas@fda.hhs.gov NR 10 TC 11 Z9 11 U1 0 U2 5 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 20 PY 2013 VL 62 IS 50 BP 1029 EP 1031 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 278AX UT WOS:000328861500003 ER PT J AU Brammer, L Epperson, S Blanton, L Kniss, K Mustaquim, D Steffens, C Dhara, R Leon, M Perez, A Chaves, S Katz, J Wallis, T Villanueva, J Xu, XY Elal, AIA Gubareva, L Finelli, L Bresee, J Cox, N Millman, A AF Brammer, Lynnette Epperson, Scott Blanton, Lenee Kniss, Krista Mustaquim, Desiree Steffens, Craig Dhara, Rosaline Leon, Michelle Perez, Alejandro Chaves, Sandra Katz, Jackie Wallis, Teresa Villanueva, Julie Xu, Xiyan Elal, Anwar Isa Abd Gubareva, Larisa Finelli, Lyn Bresee, Joseph Cox, Nancy Millman, Alexander TI Update: Influenza Activity - United States, September 29-December 7, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article RP Millman, A (reprint author), CDC, Atlanta, GA 30333 USA. EM amillman@cdc.gov NR 5 TC 3 Z9 3 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 20 PY 2013 VL 62 IS 50 BP 1032 EP 1036 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 278AX UT WOS:000328861500004 ER PT J AU Painter, JA Graviss, EA Hai, HH Nhung, DTC Nga, TTT Ha, NP Wall, K Loan, LTH Parker, M Manangan, L O'Brien, R Maloney, SA Hoekstra, RM Reves, R AF Painter, John A. Graviss, Edward A. Hoang Hoa Hai Duong Thi Cam Nhung Tran Thi Thanh Nga Ha, Ngan P. Wall, Kirsten Le Thien Huong Loan Parker, Matt Manangan, Lilia O'Brien, Rick Maloney, Susan A. Hoekstra, R. M. Reves, Randall TI Tuberculosis Screening by Tuberculosis Skin Test or QuantiFERON (R)-TB Gold In-Tube Assay among an Immigrant Population with a High Prevalence of Tuberculosis and BCG Vaccination SO PLOS ONE LA English DT Article ID GAMMA RELEASE ASSAYS; FOREIGN-BORN PERSONS; UNITED-STATES; INFECTION; DIAGNOSIS; METAANALYSIS; TB; ELIMINATION AB Rationale: Each year 1 million persons acquire permanent U. S. residency visas after tuberculosis (TB) screening. Most applicants undergo a 2-stage screening with tuberculin skin test (TST) followed by CXR only if TST-positive at > 5 mm. Due to cross reaction with bacillus Calmette-Guerin (BCG), TST may yield false positive results in BCG-vaccinated persons. Interferon gamma release assays exclude antigens found in BCG. In Vietnam, like most high TB-prevalence countries, there is universal BCG vaccination at birth. Objectives: 1. Compare the sensitivity of QuantiFERON (R)-TB Gold In-Tube Assay (QFT) and TST for culture-positive pulmonary TB. 2. Compare the age-specific and overall prevalence of positive TST and QFT among applicants with normal and abnormal CXR. Methods: We obtained TST and QFT results on 996 applicants with abnormal CXR, of whom 132 had TB, and 479 with normal CXR. Results: The sensitivity for tuberculosis was 86.4% for QFT; 89.4%, 81.1%, and 52.3% for TST at 5, 10, and 15 mm. The estimated prevalence of positive results at age 15-19 years was 22% and 42% for QFT and TST at 10 mm, respectively. The prevalence increased thereafter by 0.7% year of age for TST and 2.1% for QFT, the latter being more consistent with the increase in TB among applicants. Conclusions: During 2-stage screening, QFT is as sensitive as TST in detecting TB with fewer requiring CXR and being diagnosed with LTBI. These data support the use of QFT over TST in this population. C1 [Painter, John A.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Graviss, Edward A.; Ha, Ngan P.] Methodist Hosp Res Inst, Houston, TX USA. [Hoang Hoa Hai; Duong Thi Cam Nhung; Tran Thi Thanh Nga; Le Thien Huong Loan] Cho Ray Hosp, Visa Med Unit, Ho Chi Minh City, Vietnam. [Wall, Kirsten; Parker, Matt; Reves, Randall] Denver Hlth & Hosp Author, Denver, CO USA. [Manangan, Lilia] Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA USA. [O'Brien, Rick] Fdn Innovat New Diagnost, Geneva, Switzerland. [Maloney, Susan A.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. [Hoekstra, R. M.] Ctr Dis Control & Prevent, Biostat & Informat Management Off, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Painter, JA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM jpainter@cdc.gov FU Tuberculosis Epidemiologic Studies Consortium (TBESC) of the United States Centers for the Disease Control and Prevention FX Funding for the study was achieved through the Tuberculosis Epidemiologic Studies Consortium (TBESC) of the United States Centers for the Disease Control and Prevention. QuantiFERON (R)-TB Gold In-Tube Assay kits were provided by the Foundation for Innovative New Diagnostics. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 11 Z9 11 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 19 PY 2013 VL 8 IS 12 AR UNSP e82727 DI 10.1371/journal.pone.0082727 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276HY UT WOS:000328741900012 PM 24367546 ER PT J AU Niederkrotenthaler, T Parker, EM Ovalle, F Noe, RE Bell, J Xu, LK Morrison, MA Mertzlufft, CE Sugerman, DE AF Niederkrotenthaler, Thomas Parker, Erin M. Ovalle, Fernando Noe, Rebecca E. Bell, Jeneita Xu, Likang Morrison, Melissa A. Mertzlufft, Caitlin E. Sugerman, David E. TI Injuries and Post-Traumatic Stress following Historic Tornados: Alabama, April 2011 SO PLOS ONE LA English DT Article ID RISK-FACTORS; DISASTER PREPAREDNESS; NATURAL DISASTER; DISORDER; OKLAHOMA; DEATH; BANGLADESH; ILLINOIS; GEORGIA; SYSTEM AB Objectives: We analyzed tornado-related injuries seen at hospitals and risk factors for tornado injury, and screened for post-traumatic stress following a statewide tornado-emergency in Alabama in April 2011. Methods: We conducted a chart abstraction of 1,398 patients at 39 hospitals, mapped injured cases, and conducted a case-control telephone survey of 98 injured cases along with 200 uninjured controls. Results: Most (n = 1,111, 79.5%) injuries treated were non-life threatening (Injury Severity Score <= 15). Severe injuries often affected head (72.9%) and chest regions (86.4%). Mobile home residents showed the highest odds of injury (OR, 6.98; 95% CI: 2.10-23.20). No severe injuries occurred in tornado shelters. Within permanent homes, the odds of injury were decreased for basements (OR, 0.13; 95% CI: 0.04-0.40), bathrooms (OR, 0.22; 95% CI: 0.06-0.78), hallways (OR, 0.31; 95% CI: 0.11-0.90) and closets (OR, 0.25; 95% CI: 0.07-0.80). Exposure to warnings via the Internet (aOR, 0.20; 95% CI: 0.09-0.49), television (aOR, 0.45; 95% CI: 0.24-0.83), and sirens (aOR, 0.50; 95% CI: 0.30-0.85) decreased the odds of injury, and residents frequently exposed to tornado sirens had lower odds of injury. The prevalence of PTSD in respondents was 22.1% and screening positive for PTSD symptoms was associated with tornado-related loss events. Conclusions: Primary prevention, particularly improved shelter access, and media warnings, seem essential to prevent severe tornado-injury. Small rooms such as bathrooms may provide some protection within permanent homes when no underground shelter is available. C1 [Niederkrotenthaler, Thomas; Parker, Erin M.; Ovalle, Fernando; Bell, Jeneita; Sugerman, David E.] Ctr Dis Control & Prevent CDC, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Atlanta, GA USA. [Niederkrotenthaler, Thomas; Parker, Erin M.] Ctr Dis Control & Prevent CDC, Sci Educ & Profess Dev Program Off, Div Appl Sci, Epidem Intelligence Serv, Atlanta, GA USA. [Noe, Rebecca E.] Ctr Dis Control & Prevent CDC, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA USA. [Xu, Likang] Ctr Dis Control & Prevent CDC, Natl Ctr Injury Prevent & Control, Div Anal Res & Practice Integrat, Atlanta, GA USA. [Morrison, Melissa A.] Ctr Dis Control & Prevent CDC, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. [Morrison, Melissa A.] Alabama Dept Publ Hlth, Montgomery, AL 36102 USA. [Mertzlufft, Caitlin E.] ATSDR, Div Toxicol & Human Hlth Sci, Geospatial Res Anal & Serv Program, Atlanta, GA USA. RP Niederkrotenthaler, T (reprint author), Med Univ Vienna, Dept Gen Practice & Family Med, Ctr Publ Hlth, Vienna, Austria. EM thomas.niederkrotenthaler@meduniwien.ac.at OI Niederkrotenthaler, Thomas/0000-0001-9550-628X NR 44 TC 3 Z9 4 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 18 PY 2013 VL 8 IS 12 AR e83038 DI 10.1371/journal.pone.0083038 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276HL UT WOS:000328740300092 PM 24367581 ER PT J AU Querec, TD Gurbaxani, BM Unger, ER AF Querec, Troy David Gurbaxani, Brian Mohan Unger, Elizabeth Robinson TI Randomization Modeling to Ascertain Clustering Patterns of Human Papillomavirus Types Detected in Cervicovaginal Samples in the United States SO PLOS ONE LA English DT Article ID GENITAL HUMAN-PAPILLOMAVIRUS; CERVICAL NEOPLASIA; HPV TYPES; HIGH-RISK; YOUNG-WOMEN; INFECTION; PREVALENCE; COINFECTION; CANCER; ABNORMALITIES AB Detection of multiple human papillomavirus (HPV) types in the genital tract is common. Associations among HPV types may impact HPV vaccination modeling and type replacement. The objectives were to determine the distribution of concurrent HPV type infections in cervicovaginal samples and examine type-specific associations. We analyzed HPV genotyping results from 32,245 cervicovaginal specimens collected from women aged 11 to 83 years in the United States from 2001 through 2011. Statistical power was enhanced by combining 6 separate studies. Expected concurrent infection frequencies from a series of permutation models, each with increasing fidelity to the real data, were compared with the observed data. Statistics were computed based on the distributional properties of the randomized data. Concurrent detection occurred more than expected with 0 or >= 3 HPV types and less than expected with 1 and 2 types. Some women bear a disproportionate burden of the HPV type prevalence. Type associations were observed that exceeded multiple hypothesis corrected significance. Multiple HPV types were detected more frequently than expected by chance and associations among particular HPV types were detected. However vaccine-targeted types were not specifically affected, supporting the expectation that current bivalent/quadrivalent HPV vaccination will not result in type replacement with other high-risk types. C1 [Querec, Troy David; Gurbaxani, Brian Mohan; Unger, Elizabeth Robinson] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA. RP Querec, TD (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA. EM tquerec@cdc.gov OI Unger, Elizabeth/0000-0002-2925-5635 FU American Society for Microbiology/Centers for Disease Control and Prevention Postdoctoral Research Fellowship Program FX The stipend for Dr. Querec was provided by the American Society for Microbiology/Centers for Disease Control and Prevention Postdoctoral Research Fellowship Program. All data were previously collected for other purposes by the Centers for Disease Control and Prevention. The funders had no role in study design, aggregating previously collected data and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 3 Z9 3 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 18 PY 2013 VL 8 IS 12 AR e82761 DI 10.1371/journal.pone.0082761 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276HL UT WOS:000328740300066 PM 24367553 ER PT J AU Samji, H Cescon, A Hogg, RS Modur, SP Althoff, KN Buchacz, K Burchell, AN Cohen, M Gebo, KA Gill, MJ Justice, A Kirk, G Klein, MB Korthuis, PT Martin, J Napravnik, S Rourke, SB Sterling, TR Silverberg, MJ Deeks, S Jacobson, LP Bosch, RJ Kitahata, MM Goedert, JJ Moore, R Gange, SJ AF Samji, Hasina Cescon, Angela Hogg, Robert S. Modur, Sharada P. Althoff, Keri N. Buchacz, Kate Burchell, Ann N. Cohen, Mardge Gebo, Kelly A. Gill, M. John Justice, Amy Kirk, Gregory Klein, Marina B. Korthuis, P. Todd Martin, Jeff Napravnik, Sonia Rourke, Sean B. Sterling, Timothy R. Silverberg, Michael J. Deeks, Stephen Jacobson, Lisa P. Bosch, Ronald J. Kitahata, Mari M. Goedert, James J. Moore, Richard Gange, Stephen J. CA North Amer AIDS Cohort TI Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; INJECTING DRUG-USERS; INFECTED PERSONS; INCOME COUNTRIES; COHORT; INEQUALITIES; MORTALITY; SURVIVAL; TIME AB Background: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U. S.) and Canada, but gains in life expectancy for this region have not been well characterized. We aim to estimate temporal changes in life expectancy among HIV-positive adults on ART from 2000-2007 in the U. S. and Canada. Methods: Participants were from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), aged >= 20 years and on ART. Mortality rates were calculated using participants' person-time from January 1, 2000 or ART initiation until death, loss to follow-up, or administrative censoring December 31, 2007. Life expectancy at age 20, defined as the average number of additional years that a person of a specific age will live, provided the current age-specific mortality rates remain constant, was estimated using abridged life tables. Results: The crude mortality rate was 19.8/1,000 person-years, among 22,937 individuals contributing 82,022 person-years and 1,622 deaths. Life expectancy increased from 36.1 [standard error (SE) 0.5] to 51.4 [SE 0.5] years from 2000-2002 to 2006-2007. Men and women had comparable life expectancies in all periods except the last (2006-2007). Life expectancy was lower for individuals with a history of injection drug use, non-whites, and in patients with baseline CD4 counts <350 cells/mm(3). Conclusions: A 20-year-old HIV-positive adult on ART in the U. S. or Canada is expected to live into their early 70 s, a life expectancy approaching that of the general population. Differences by sex, race, HIV transmission risk group, and CD4 count remain. C1 [Samji, Hasina; Cescon, Angela; Hogg, Robert S.] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Hogg, Robert S.] Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada. [Modur, Sharada P.; Althoff, Keri N.; Gebo, Kelly A.; Kirk, Gregory; Jacobson, Lisa P.; Moore, Richard; Gange, Stephen J.] Johns Hopkins Univ, Baltimore, MD USA. [Buchacz, Kate] Ctr Dis Control & Prevent, Atlanta, GA USA. [Burchell, Ann N.; Rourke, Sean B.] Ontario HIV Treatment Network, Toronto, ON, Canada. [Cohen, Mardge] Bur Hlth Serv Cook Cty, Core Ctr, Chicago, IL USA. [Gill, M. John] Univ Calgary, Calgary, AB, Canada. [Justice, Amy] Vet Adm Connecticut Healthcare Syst, West Haven, CT USA. [Justice, Amy] Yale Univ, West Haven, CT USA. [Klein, Marina B.] McGill Univ, Ctr Hlth, Montreal, PQ, Canada. [Korthuis, P. Todd] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Martin, Jeff] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Napravnik, Sonia] Univ N Carolina, Chapel Hill, NC USA. [Sterling, Timothy R.] Vanderbilt Univ, Nashville, TN 37235 USA. [Silverberg, Michael J.] Kaiser Permanente No Calif, Oakland, CA USA. [Deeks, Stephen] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA USA. [Bosch, Ronald J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Kitahata, Mari M.] Univ Washington, Seattle, WA 98195 USA. [Goedert, James J.] NCI, Rockville, MD USA. RP Hogg, RS (reprint author), British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada. EM rhogg@sfu.ca RI Gill, John/G-7083-2016; OI Gill, John/0000-0002-8546-8790; Gange, Stephen/0000-0001-7842-512X; Hogg, Robert/0000-0003-3463-5488 FU National Institutes of Health [U01-AI069918, U10-AA13566, U01-AI31834, U01-AI34989, U01-AI34993, U01-AI34994, U01-AI35004, U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, U01-AI35043, U01-AI37613, U01-AI37984, U01-AI38855, U01-AI38858, U01-AI42590, U01-AI68634, U01-AI68636, U01-HD32632, U10-EY08057, U10-EY08052, U10-EY08067, UL1-RR024131, M01-RR-00052, M01-RR00071, M01-RR00079, M01-RR00083, M01-RR00722, M01-RR025747, P30-AI27757, P30-AI27767, P30-AI27763, P30-AI50410, P30-AI54999, R01-DA04334, R01-DA12568, R01-DA11602, R01-AA16893, R24-AI067039, Z01-CP010176, AHQ290-01-0012, N02-CP55504, AI-69432, AI-69434, K01-AI071725, K23-AI610320, K23-EY013707, K24-DA00432, K24 AI65298, K01-AI093197]; Agency for Healthcare Research and Quality [290-01-0012]; CDC [CDC200-2006-18797]; Canadian Institutes of Health Research [TGF-96118, HCP-97105, CBR-86906, CBR-94036, KRS-86251, 169621]; Canadian HIV Trials Network [24]; government of British Columbia FX This work was supported by grants U01-AI069918, U10-AA13566, U01-AI31834, U01-AI34989, U01-AI34993, U01-AI34994, U01-AI35004, U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, U01-AI35043, U01-AI37613, U01-AI37984, U01-AI38855, U01-AI38858, U01-AI42590, U01-AI68634, U01-AI68636, U01-HD32632, U10-EY08057, U10-EY08052, U10-EY08067, UL1-RR024131, UL1-RR024131, M01-RR-00052, M01-RR00071, M01-RR00079, M01-RR00083, M01-RR00722, M01-RR025747, P30-AI27757, P30-AI27767, P30-AI27763, P30-AI50410, P30-AI54999, R01-DA04334, R01-DA12568, R01-DA11602, R01-AA16893, R24-AI067039, Z01-CP010176, AHQ290-01-0012, N02-CP55504, AI-69432, AI-69434, K01-AI071725, K23-AI610320, K23-EY013707, K24-DA00432, K24 AI65298 and K01-AI093197 from the National Institutes of Health; contract 290-01-0012 from the Agency for Healthcare Research and Quality; contract CDC200-2006-18797 from the CDC; grants TGF-96118, HCP-97105, CBR-86906, CBR-94036, KRS-86251, and 169621 from the Canadian Institutes of Health Research; the Canadian HIV Trials Network, project 24; and the government of British Columbia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 240 Z9 241 U1 2 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 18 PY 2013 VL 8 IS 12 AR e81355 DI 10.1371/journal.pone.0081355 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276HL UT WOS:000328740300004 PM 24367482 ER PT J AU Krause, PR Bialek, SR Boppana, SB Griffiths, PD Laughlin, CA Ljungman, P Mocarski, ES Pass, RF Read, JS Schleiss, MR Plotkin, SA AF Krause, Philip R. Bialek, Stephanie R. Boppana, Suresh B. Griffiths, Paul D. Laughlin, Catherine A. Ljungman, Per Mocarski, Edward S. Pass, Robert F. Read, Jennifer S. Schleiss, Mark R. Plotkin, Stanley A. TI Priorities for CMV vaccine development SO VACCINE LA English DT Review DE Cytomegalovirus; Congenital CMV; Viruses; Clinical trial endpoints; Meeting report ID CONGENITAL CYTOMEGALOVIRUS-INFECTION; ORGAN TRANSPLANT RECIPIENTS; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; GLYCOPROTEIN-B VACCINE; DOUBLE-BLIND; ADVISORY-COMMITTEE; HEARING-LOSS; DISEASE; IMMUNIZATION AB A multidisciplinary meeting addressed priorities related to development of vaccines against cytomegalovirus (CMV), the cause of congenital CMV (cCMV) disease and of serious disease in the immunocompromised. Participants discussed optimal uses of a CMV vaccine, aspects of clinical study design, and the value of additional research. A universal childhood CMV vaccine could potentially rapidly reduce cCMV disease, as infected children are sources of viral transmission to seronegative and seropositive mothers. A vaccine administered to adolescents or adult women could also reduce cCMV disease by making them immune prior to pregnancy. Clinical trials of CMV vaccines in women should evaluate protection against cCMV infection, an essential precursor of cCMV disease, which is a more practical and acceptable endpoint for assessing vaccine effects on maternal-fetal transmission. Clinical trials of vaccines to evaluate prevention of CMV disease in stem cell transplant recipients could use CMV viremia at a level triggering pre-emptive antiviral therapy as an endpoint, because widespread use of pre-emptive and prophylactic antivirals has rendered CMV-induced disease too rare to be a practical endpoint for clinical trials. In solid organ transplant patients, CMV-associated disease is sufficiently common for use as a primary endpoint. Additional research to advance CMV vaccine development should include identifying factors that predict fetal loss due to CMV, determining age-specific incidence and transmission rates, defining the mechanism and relative contributions of maternal reactivation and reinfection to cCMV disease, developing assays that can distinguish between reactivation and re-infection in seropositive vaccinees, further defining predictors of sequelae from cCMV infection, and identifying clinically relevant immune response parameters to CMV (including developing validated assays that could assess CMV antibody avidity) that could lead to the establishment of immune correlates of protection. Published by Elsevier Ltd. C1 [Krause, Philip R.] US FDA, Off Vaccines Res & Review, CBER, Bethesda, MD 20014 USA. [Bialek, Stephanie R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Boppana, Suresh B.; Pass, Robert F.] Univ Alabama Birmingham, Birmingham, AL USA. [Griffiths, Paul D.] UCL, London WC1E 6BT, England. [Laughlin, Catherine A.] NIAID, NIH, Bethesda, MD USA. [Ljungman, Per] Karolinska Inst, Stockholm, Sweden. [Mocarski, Edward S.] Emory Univ, Atlanta, GA 30322 USA. [Read, Jennifer S.] Natl Vaccine Program Off, Washington, DC USA. [Schleiss, Mark R.] Univ Minnesota, Minneapolis, MN USA. [Plotkin, Stanley A.] Univ Penn, Philadelphia, PA 19104 USA. RP Krause, PR (reprint author), US FDA, Off Vaccines Res & Review, CBER, 29 Lincoln Dr, Bethesda, MD 20014 USA. EM philip.krause@fda.hhs.gov; zqg7@cdc.gov; sboppana@peds.uab.edu; p.griffiths@ucl.ac.uk; CLaughlin@niaid.nih.gov; Per.Ljungman@ki.se; mocarski@emory.edu; RPass@peds.uab.edu; Jennifer.Read@fda.hhs.gov; schleiss@umn.edu; stanley.plotkin@vaxconsult.com OI Krause, Philip/0000-0002-1045-7536 FU Food and Drug Administration; National Institutes of Health; Centers for Disease Control and Prevention; National Vaccine Program Office FX We acknowledge the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the National Vaccine Program Office for sponsorship of the CMV Vaccine Workshop, held in Bethesda, MD on the NIH Campus on January 11-12, 2012. We also thank the presenters and participants at the meeting for excellent discussions that enabled a highly productive meeting. NR 55 TC 36 Z9 37 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 17 PY 2013 VL 32 IS 1 BP 4 EP 10 DI 10.1016/j.vaccine.2013.09.042 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289LT UT WOS:000329684700003 PM 24129123 ER PT J AU Fitter, DL Anselme, R Paluku, G Rey, G Flannery, B Tohme, RA Marston, BJ Griswold, M Boncy, J Vertefeuille, JF AF Fitter, David L. Anselme, Renette Paluku, Gilson Rey, Gloria Flannery, Brendan Tohme, Rania A. Marston, Barbara J. Griswold, Mark Boncy, Jacques Vertefeuille, John F. TI Seroprevalence of measles and rubella antibodies in pregnant women Haiti, 2012 SO VACCINE LA English DT Article DE Measles; Rubella; Seroprevalence; Vaccine; IgG antibody ID VACCINATION CAMPAIGN; ELIMINATION AB Background: Haiti had set a national goal to eliminate measles and rubella, as well as congenital rubella syndrome (CRS) by 2010. A 2007-2008 nationwide measles and rubella vaccination campaign targeting 1-19 years, however, reached only 79% of the target population. To assess whether population immunity was adequate to support elimination, we conducted a national serosurvey. Methods: We systematically selected 740 serum specimens collected from pregnant women in a 2012 national antenatal HIV sentinel serosurvey across four age strata: 15-19, 20-24, 25-29 and 30-39 years. Sera were tested for measles and rubella specific immunoglobulin G antibodies (IgG) using commercial immunoassays. We classified sera as seropositive, seronegative or indeterminate per manufacturer's instructions, and analyzed seroprevalence according to age strata, and rural or urban residence. We assessed immunity by estimating antibody concentrations in international units per milliliter (IU/mL) for seropositive and indeterminate sera. Measles IgG concentrations >0.12 IU/mL and rubella IgG concentrations >10 IU/mL were considered clinically protective. Results: Of 740 sera, 696 (94.1%) were seropositive and 20 (2.7%) were indeterminate for measles IgG; overall 716 (96.8%) sera had IgG concentrations >0.12 IU/mL. For rubella IgG, 691 (93.4%) sera were seropositive and 1(0.1%) was indeterminate; a total of 687 (92.8%) had IgG concentrations >10 IU/mL. Measles seropositivity varied across age strata (p = 0.003); seropositivity increased from 88.6% among 15-19 year olds to 98.4% among 30-39 year olds (Cochran-Armitage trend test <= 0.0001). Rubella seropositivity did not differ across age strata. There were no statistically significant differences in measles or rubella seropositivity by urban versus rural residence. Conclusion: Despite previous low vaccination coverage for measles, results from this serosurvey indicate high levels of measles and rubella seropositivity in pregnant women, and contribute to the evidence for measles, rubella and CRS elimination from Haiti by the target date. Published by Elsevier Ltd. C1 [Fitter, David L.; Marston, Barbara J.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Fitter, David L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA 30333 USA. [Paluku, Gilson] Pan Amer Hlth Org, Port Au Prince, Haiti. [Rey, Gloria] Pan Amer Hlth Org, San Jose, Costa Rica. [Flannery, Brendan; Tohme, Rania A.] Ctr Dis Control & Prevent, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Griswold, Mark] Natl Alliance State & Territorial AIDS Directors, Global Program, Washington, DC USA. [Vertefeuille, John F.] US Ctr Dis Control & Prevent, Haiti Country Off, Port Au Prince, Haiti. RP Fitter, DL (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A-05, Atlanta, GA 30333 USA. EM dfitter@cdc.gov FU Centers for Disease Control and Prevention; Pan American Health Organization FX This work was supported by the Centers for Disease Control and Prevention and the Pan American Health Organization. NR 15 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 17 PY 2013 VL 32 IS 1 BP 69 EP 73 DI 10.1016/j.vaccine.2013.10.071 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 289LT UT WOS:000329684700012 PM 24188751 ER PT J AU Quashie, NB Duah, NO Abuaku, B Quaye, L Ayanful-Torgby, R Akwoviah, GA Kweku, M Johnson, JD Lucchi, NW Udhayakumar, V Duplessis, C Kronmann, KC Koram, KA AF Quashie, Neils B. Duah, Nancy O. Abuaku, Benjamin Quaye, Lydia Ayanful-Torgby, Ruth Akwoviah, George A. Kweku, Margaret Johnson, Jacob D. Lucchi, Naomi W. Udhayakumar, Venkatachalam Duplessis, Christopher Kronmann, Karl C. Koram, Kwadwo A. TI A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs SO MALARIA JOURNAL LA English DT Article DE Isolates; in vitro; Susceptibility; Inhibition; Plasmodium falciparum ID CHLOROQUINE RESISTANCE; UNCOMPLICATED MALARIA; PFMDR1 GENE; MEFLOQUINE; AFRICA; MUTATIONS; EFFICACY; ASSAY; WEST; ANTIBIOTICS AB Background: Based on report of declining efficacy of chloroquine, Ghana shifted to the use of artemisinin-based combination therapy (ACT) in 2005 as the first-line anti-malarial drug. Since then, there has not been any major evaluation of the efficacy of anti-malarial drugs in Ghana in vitro. The sensitivity of Ghanaian Plasmodium falciparum isolates to anti-malarial drugs was, therefore, assessed and the data compared with that obtained prior to the change in the malaria treatment policy. Methods: A SYBR Green 1 fluorescent-based in vitro drug sensitivity assay was used to assess the susceptibility of clinical isolates of P. falciparum to a panel of 12 anti-malarial drugs in three distinct eco-epidemiological zones in Ghana. The isolates were obtained from children visiting health facilities in sentinel sites located in Hohoe, Navrongo and Cape Coast municipalities. The concentration of anti-malarial drug inhibiting parasite growth by 50% (IC50) for each drug was estimated using the online program, ICEstimator. Results: Pooled results from all the sentinel sites indicated geometric mean IC50 values of 1.60, 3.80, 4.00, 4.56, 5.20, 6.11, 10.12, 28.32, 31.56, 93.60, 107.20, and 8952.50 nM for atovaquone, artesunate, dihydroartemisin, artemether, lumefantrine, amodiaquine, mefloquine, piperaquine, chloroquine, tafenoquine, quinine, and doxycycline, respectively. With reference to the literature threshold value indicative of resistance, the parasites showed resistance to all the test drugs except the artemisinin derivatives, atovaquone and to a lesser extent, lumefantrine. There was nearly a two-fold decrease in the IC50 value determined for chloroquine in this study compared to that determined in 2004 (57.56 nM). This observation is important, since it suggests a significant improvement in the efficacy of chloroquine, probably as a direct consequence of reduced drug pressure after cessation of its use. Compared to that measured prior to the change in treatment policy, significant elevation of artesunate IC50 value was observed. The results also suggest the existence of possible cross-resistance among some of the test drugs. Conclusion: Ghanaian P. falciparum isolates, to some extent, have become susceptible to chloroquine in vitro, however the increasing trend in artesunate IC50 value observed should be of concern. Continuous monitoring of ACT in Ghana is recommended. C1 [Quashie, Neils B.] Univ Ghana, Sch Med, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana. [Quashie, Neils B.; Duah, Nancy O.; Abuaku, Benjamin; Quaye, Lydia; Ayanful-Torgby, Ruth; Akwoviah, George A.; Koram, Kwadwo A.] Univ Ghana, Noguchi Mem Inst Med Res, Dept Epidemiol, Accra, Ghana. [Duplessis, Christopher; Kronmann, Karl C.] US Naval Med Res Unit 3, Cairo, Egypt. [Kweku, Margaret] Hohoe Hlth Res Ctr, Hohoe, Ghana. [Johnson, Jacob D.] US Army Med Res Unit Kenya, Kenya Med Res Inst, Walter Reed Project, Dept Emerging,Infect Dis Program, Kisumu, Kenya. [Lucchi, Naomi W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Quashie, NB (reprint author), Univ Ghana, Sch Med, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana. EM nquashie@noguchi.ug.edu.gh OI Duah, Nancy/0000-0001-8819-1793 FU Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center (AFHSC) [C0437_11_N3]; Global Fund FX The Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center (AFHSC) [Project no. C0437_11_N3] funded this work. WWARN is acknowledged for providing the anti-malarial drugs used in this study. We also thank CDC for donating a field-based customized fluorescence plate reader for the project and training. We thank Dr Jacob Johnson and Mr Hosea Akala (Department of Emerging Infectious Diseases Program, US Army Medical Research Unit-Kenya, Kenya Medical Research Institute-Walter Reed Project, Kisumu, Kenya) for training the NMIMR Group on the use of the SYBR Green method. We also thank the teams in Hohoe Municipal Hospital, Likpe-Bakwa Health Centre, Navrongo War Memorial Hospital, Ewim Health Centre, Cape Coast and Central Regional Hospital. We acknowledge the cooperation of the Navrongo Health Research. The sentinel sites were originally set up by the Noguchi Memorial Institute for Medical Research in collaboration with the NMCP and supported financially with the Global Fund. NR 55 TC 11 Z9 11 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 17 PY 2013 VL 12 AR 450 DI 10.1186/1475-2875-12-450 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 281OO UT WOS:000329111100001 PM 24341604 ER PT J AU King, R Barker, J Nakayiwa, S Katuntu, D Lubwama, G Bagenda, D Lane, T Opio, A Hladik, W AF King, Rachel Barker, Joseph Nakayiwa, Sylvia Katuntu, David Lubwama, George Bagenda, Danstan Lane, Tim Opio, Alex Hladik, Wolfgang TI Men at Risk; a Qualitative Study on HIV Risk, Gender Identity and Violence among Men Who Have Sex with Men Who Report High Risk Behavior in Kampala, Uganda SO PLOS ONE LA English DT Article ID SUB-SAHARAN AFRICA; BISEXUAL MEN; SOUTH-AFRICA; WORKERS; KENYA; HIV/AIDS; MOMBASA; GAY AB In Uganda, men who have sex with men (MSM) are at high risk for HIV. Between May 2008 and February 2009 in Kampala, Uganda, we used respondent driven sampling (RDS) to recruit 295 MSM >= 18 years who reported having had sex with another man in the preceding three months. The parent study conducted HIV and STI testing and collected demographic and HIV-related behavioral data through audio computer-assisted self-administered interviews. We conducted a nested qualitative sub-study with 16 men purposively sampled from among the survey participants based on responses to behavioral variables indicating higher risk for HIV infection. Sub-study participants were interviewed face-to-face. Domains of inquiry included sexual orientation, gender identity, condom use, stigma, discrimination, violence and health seeking behavior. Emergent themes included a description of sexual orientation/gender identity categories. All groups of men described conflicting feelings related to their sexual orientation and contextual issues that do not accept same-sex identities or behaviors and non-normative gender presentation. The emerging domains for facilitating condom use included: lack of trust in partner and fear of HIV infection. We discuss themes in the context of social and policy issues surrounding homosexuality and HIV prevention in Uganda that directly affect men's lives, risk and health-promoting behaviors. C1 [King, Rachel; Lane, Tim] Univ Calif San Francisco, Global Hlth Sci, San Francisco, CA 94143 USA. [King, Rachel; Barker, Joseph; Nakayiwa, Sylvia; Katuntu, David; Hladik, Wolfgang] Ctr Dis Control & Prevent CDC, Ctr Global Hlth, Div Global HIV AIDS, Entebbe, Uganda. [Lubwama, George; Bagenda, Danstan] Makerere Univ, Sch Publ Hlth MakSPH, Kampala, Uganda. [Opio, Alex; Hladik, Wolfgang] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol, NL-1012 WX Amsterdam, Netherlands. Minist Hlth, Kampala, Uganda. [Barker, Joseph; Hladik, Wolfgang] Ctr Dis Control & Prevent CDC, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA. RP King, R (reprint author), Univ Calif San Francisco, Global Hlth Sci, San Francisco, CA 94143 USA. EM rlking@psg.ucsf.edu FU US President's Emergency Plan for AIDS Relief FX This study was funded by the US President's Emergency Plan for AIDS Relief. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 15 Z9 15 U1 1 U2 19 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 17 PY 2013 VL 8 IS 12 AR e82937 DI 10.1371/journal.pone.0082937 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276GT UT WOS:000328737700040 PM 24358239 ER PT J AU Phinney, KW Ballihaut, G Bedner, M Benford, BS Camara, JE Christopher, SJ Davis, WC Dodder, NG Eppe, G Lang, BE Long, SE Lowenthal, MS McGaw, EA Murphy, KE Nelson, BC Prendergast, JL Reiner, JL Rimmer, CA Sander, LC Schantz, MM Sharpless, KE Sniegoski, LT Tai, SSC Thomas, JB Vetter, TW Welch, MJ Wise, SA Wood, LJ Guthrie, WF Hagwood, CR Leigh, SD Yen, JH Zhang, NF Chaudhary-Webb, M Chen, HP Fazili, Z LaVoie, DJ McCoy, LF Momin, SS Paladugula, N Pendergrast, EC Pfeiffer, CM Powers, CD Rabinowitz, D Rybak, ME Schleicher, RL Toombs, BMH Xu, M Zhang, M Castle, AL AF Phinney, Karen W. Ballihaut, Guillaume Bedner, Mary Benford, Brandi S. Camara, Johanna E. Christopher, Steven J. Davis, W. Clay Dodder, Nathan G. Eppe, Gauthier Lang, Brian E. Long, Stephen E. Lowenthal, Mark S. McGaw, Elizabeth A. Murphy, Karen E. Nelson, Bryant C. Prendergast, Jocelyn L. Reiner, Jessica L. Rimmer, Catherine A. Sander, Lane C. Schantz, Michele M. Sharpless, Katherine E. Sniegoski, Lorna T. Tai, Susan S. -C. Thomas, Jeanice B. Vetter, Thomas W. Welch, Michael J. Wise, Stephen A. Wood, Laura J. Guthrie, William F. Hagwood, Charles R. Leigh, Stefan D. Yen, James H. Zhang, Nien-Fan Chaudhary-Webb, Madhu Chen, Huiping Fazili, Zia LaVoie, Donna J. McCoy, Leslie F. Momin, Shahzad S. Paladugula, Neelima Pendergrast, Elizabeth C. Pfeiffer, Christine M. Powers, Carissa D. Rabinowitz, Daniel Rybak, Michael E. Schleicher, Rosemary L. Toombs, Bridgette M. H. Xu, Mary Zhang, Mindy Castle, Arthur L. TI Development of a Standard Reference Material for Metabolomics Research SO ANALYTICAL CHEMISTRY LA English DT Article ID HUMAN PLASMA; MASS-SPECTROMETRY; HUMAN URINE; METABONOMIC ANALYSIS; DIABETES-MELLITUS; ACID-METABOLISM; HPLC-MS; DISEASE; SPECTROSCOPY; PERFORMANCE AB The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NTH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research. C1 [Phinney, Karen W.; Lowenthal, Mark S.] NIST, Biomol Measurement Div, Gaithersburg, MD 20899 USA. [Ballihaut, Guillaume; Bedner, Mary; Benford, Brandi S.; Camara, Johanna E.; Christopher, Steven J.; Davis, W. Clay; Dodder, Nathan G.; Eppe, Gauthier; Long, Stephen E.; McGaw, Elizabeth A.; Murphy, Karen E.; Prendergast, Jocelyn L.; Reiner, Jessica L.; Rimmer, Catherine A.; Sander, Lane C.; Schantz, Michele M.; Sharpless, Katherine E.; Sniegoski, Lorna T.; Tai, Susan S. -C.; Thomas, Jeanice B.; Vetter, Thomas W.; Welch, Michael J.; Wise, Stephen A.; Wood, Laura J.] NIST, Div Chem Sci, Gaithersburg, MD 20899 USA. [Lang, Brian E.; Nelson, Bryant C.] NIST, Biosyst & Biomat Div, Gaithersburg, MD 20899 USA. [Guthrie, William F.; Hagwood, Charles R.; Leigh, Stefan D.; Yen, James H.; Zhang, Nien-Fan] NIST, Stat Engn Div, Gaithersburg, MD 20899 USA. [Chaudhary-Webb, Madhu; Chen, Huiping; Fazili, Zia; LaVoie, Donna J.; McCoy, Leslie F.; Momin, Shahzad S.; Paladugula, Neelima; Pendergrast, Elizabeth C.; Pfeiffer, Christine M.; Powers, Carissa D.; Rabinowitz, Daniel; Rybak, Michael E.; Schleicher, Rosemary L.; Toombs, Bridgette M. H.; Xu, Mary; Zhang, Mindy] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Castle, Arthur L.] NIDDK, NIH, Bethesda, MD 20892 USA. RP Phinney, KW (reprint author), NIST, Biomol Measurement Div, Gaithersburg, MD 20899 USA. EM karen.phinney@nist.gov RI Dodder, Nathan/C-7971-2015; OI Dodder, Nathan/0000-0001-5913-1767; Rybak, Michael/0000-0003-1650-8581 FU Intramural CDC HHS [CC999999] NR 62 TC 21 Z9 21 U1 6 U2 53 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD DEC 17 PY 2013 VL 85 IS 24 BP 11732 EP 11738 DI 10.1021/ac402689t PG 7 WC Chemistry, Analytical SC Chemistry GA 277CV UT WOS:000328797200012 PM 24187941 ER PT J AU Nishizawa, M Hattori, J Shiino, T Matano, T Heneine, W Johnson, JA Sugiura, W AF Nishizawa, Masako Hattori, Junko Shiino, Teiichiro Matano, Tetsuro Heneine, Walid Johnson, Jeffrey A. Sugiura, Wataru TI Highly-Sensitive Allele-Specific PCR Testing Identifies a Greater Prevalence of Transmitted HIV Drug Resistance in Japan SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; TREATMENT-NAIVE PATIENTS; ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; LOW-FREQUENCY; IN-VIVO; MUTATIONS; FITNESS; NEVIRAPINE; MUTANTS AB Background: The transmission of drug-resistant HIV in newly identified infected populations has become an underlying epidemic which can be better assessed with sensitive resistance testing. Since minority drug resistant variants cannot be detected by bulk sequencing, methods with improved sensitivity are required. Thus, the goal of this study was to evaluate if transmitted drug resistance mutations at minority levels in Japanese patients could be identified using highly sensitive allele-specific PCR (AS-PCR). Materials and Methods: Samples were taken from newly diagnosed HIV/AIDS cases at the National Nagoya Hospital from January 2008 to December 2009. All samples were bulk sequenced for HIV protease and reverse transcriptase. To detect minority populations with drug resistance, we used AS-PCR with mutation-specific primers designed for seven reverse transcriptase inhibitor resistance mutations, M41L, K65R, K70R, K103N, Y181C, M184V, and T215F/Y, and for three protease inhibitor resistance mutations, M46I/L and L90M. Results: We studied 149 newly identified HIV cases. Bulk sequencing detected 8 cases with NRTI resistance mutations (one with A62V, one D67E, one T215D, one T215E, two with T215L and two T215S) and 15 with PI resistance mutations (one with N88D and 14 with M46I). Results obtained by AS-PCR and bulk sequencing demonstrated good concordance but the AS-PCR enabled the detection of seven additional drug-resistant cases (one M41L, two with K65R, two with K70R, and one M184V) in the RT region. Additionally, AS-PCR assays identified 15 additional cases with M46I, five with M46L and four cases with L90M in the protease region. Conclusions: Using AS-PCR substantially increased the detection of transmitted drug resistance in this population from 15.4% to 26.8%, further supporting the benefit of sensitive testing among drug-naive populations. Since the clinical impact of minority drug-resistant populations is not fully comprehended for all mutations, follow-up studies are needed to understand their significance for treatment. C1 [Nishizawa, Masako; Shiino, Teiichiro; Matano, Tetsuro; Sugiura, Wataru] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan. [Hattori, Junko; Sugiura, Wataru] Nagoya Med Ctr, Natl Hosp Org, Clin Res Ctr, Nagoya, Aichi, Japan. [Heneine, Walid; Johnson, Jeffrey A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Sugiura, Wataru] Nagoya Univ, Grad Sch Med, Dept AIDS Res, Nagoya, Aichi 4648601, Japan. RP Sugiura, W (reprint author), Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan. EM wsugiura@nnh.hosp.go.jp FU Ministry of Health, Labour, and Welfare of Japan [H22-AIDS-004] FX This work was supported by a Grant-in-Aid for AIDS research from the Ministry of Health, Labour, and Welfare of Japan [H22-AIDS-004]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 2 Z9 2 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 16 PY 2013 VL 8 IS 12 AR UNSP e83150 DI 10.1371/journal.pone.0083150 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276GD UT WOS:000328735700106 PM 24358257 ER PT J AU Dams-O'Connor, K Cuthbert, JP Whyte, J Corrigan, JD Faul, M Harrison-Felix, C AF Dams-O'Connor, Kristen Cuthbert, Jeffrey P. Whyte, John Corrigan, John D. Faul, Mark Harrison-Felix, Cynthia TI Traumatic Brain Injury among Older Adults at Level I and II Trauma Centers SO JOURNAL OF NEUROTRAUMA LA English DT Article DE adult brain injury; epidemiology; geriatric brain injury; traumatic brain injury ID PROSPECTIVE MULTICENTER TRIAL; GERIATRIC TRAUMA; UNITED-STATES; MORTALITY; AGE; SEVERITY; CARE; HOSPITALIZATIONS; ASSOCIATION; POPULATION AB Individuals 65 years of age and over have the highest rates of traumatic brain injury (TBI)-related hospitalizations and deaths, and older adults (defined variably across studies) have particularly poor outcomes after TBI. The factors predicting these outcomes remain poorly understood, and age-specific care guidelines for TBI do not exist. This study provides an overview of TBI in older adults using data from the National Trauma Data Bank (NTDB) gathered between 2007 and 2010, evaluates age group-specific trends in rates of TBI over time using U.S. Census data, and examines whether routinely collected information is able to predict hospital discharge status among older adults with TBI in the NTDB. Results showed a 20-25% increase in trauma center admissions for TBI among the oldest age groups (those >=75 years), relative to the general population, between 2007 and 2010. Older adults (>=65 years) with TBI tended to be white females who have incurred an injury from a fall resulting in a severe Abbreviated Injury Scale (AIS) score of the head. Older adults had more in-hospital procedures, such as neuroimaging and neurosurgery, tended to experience longer hospital stays, and were more likely to require continued medical care than younger adults. Older age, injury severity, and hypotension increased the odds of in-hospital death. The public health burden of TBI among older adults will likely increase as the Baby Boom generation ages. Improved primary and secondary prevention of TBI in this cohort is needed. C1 [Dams-O'Connor, Kristen] Icahn Sch Med Mt Sinai, Dept Rehabil Med, New York, NY 10029 USA. [Cuthbert, Jeffrey P.; Harrison-Felix, Cynthia] Craig Hosp, Res Dept, Englewood, CO USA. [Whyte, John] Albert Einstein Healthcare Network, Moss Rehabil Res Inst, Elkins Pk, PA USA. [Corrigan, John D.] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA. [Faul, Mark] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Dams-O'Connor, K (reprint author), Icahn Sch Med Mt Sinai, Dept Rehabil Med, 1 Gustave Levy Pl,Box 1240B, New York, NY 10029 USA. EM kdams13@gmail.com NR 51 TC 14 Z9 14 U1 1 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC 15 PY 2013 VL 30 IS 24 BP 2001 EP 2013 DI 10.1089/neu.2013.3047 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 271QK UT WOS:000328406500001 PM 23962046 ER PT J AU Scinicariello, F Buser, MC Mevissen, M Portier, CJ AF Scinicariello, Franco Buser, Melanie C. Mevissen, Meike Portier, Christopher J. TI Blood lead level association with lower body weight in NHANES 1999-2006 SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Obesity; Body mass index; Lead; NHANES; Children; Adults ID GROWTH STATUS; EXPOSURE; OBESITY; CHILDREN; BONE; STRESS; ONSET AB Background: Lead exposure is associated with low birth-weight. The objective of this study is to determine whether lead exposure is associated with lower body weight in children, adolescents and adults. Methods: We analyzed data from NHANES 1999-2006 for participants aged >= 3 using multiple logistic and multivariate linear regression. Using age- and sex-standardized BMI Z-scores, overweight and obese children (ages 3-19) were classified by BMI >= 85th and >= 95th percentiles, respectively. The adult population (age >= 20) was classified as overweight and obese with BMI measures of 25-29.9 and >= 30, respectively. Blood lead level (BLL) was categorized by weighted quartiles. Results: Multivariate linear regressions revealed a lower BMI Z-score in children and adolescents when the highest lead quartile was compared to the lowest lead quartile (beta (SE) = -033 (0.07), p < 0.001), and a decreased BMI in adults (beta (SE) = -2.58 (025), p < 0.001). Multiple logistic analyses in children and adolescents found a negative association between BLL and the percentage of obese and overweight with BLL in the highest quartile compared to the lowest quartile (OR = 0.42, 95% CI: 030-0.59; and OR = 0.67, 95% CI: 052-0.88, respectively). Adults in the highest lead quartile were less likely to be obese (OR = 0.42,95% CI: 035-0.50) compared to those in the lowest lead quartile. Further analyses with blood lead as restricted cubic splines, confirmed the dose-relationship between blood lead and body weight outcomes. Conclusions: BLLs are associated with lower body mass index and obesity in children, adolescents and adults. Published by Elsevier Inc. C1 [Scinicariello, Franco; Buser, Melanie C.] Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA USA. [Mevissen, Meike] Univ Bern, Vetsuisse Fac, Div Vet Pharmacol & Toxicol, CH-3012 Bern, Switzerland. [Portier, Christopher J.] CDC, Natl Ctr Environm Hlth NCEH ATSDR, Atlanta, GA 30341 USA. RP Scinicariello, F (reprint author), Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, 4770 Buford Hwy,MS F61, Atlanta, GA 30341 USA. EM fes6@cdc.gov RI Portier, Christopher/A-3160-2010 OI Portier, Christopher/0000-0002-0954-0279 FU Research Participation Program at the Centers for Disease Control and Prevention FX This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC (MCB). NR 37 TC 8 Z9 8 U1 0 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD DEC 15 PY 2013 VL 273 IS 3 BP 516 EP 523 DI 10.1016/j.taap.2013.09.022 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 275XC UT WOS:000328711700011 PM 24099784 ER PT J AU Jhung, MA Epperson, S Biggerstaff, M Allen, D Balish, A Barnes, N Beaudoin, A Berman, L Bidol, S Blanton, L Blythe, D Brammer, L D'Mello, T Danila, R Davis, W de Fijter, S DiOrio, M Durand, LO Emery, S Fowler, B Garten, R Grant, Y Greenbaum, A Gubareva, L Havers, F Haupt, T House, J Ibrahim, S Jiang, V Jain, S Jernigan, D Kazmierczak, J Klimov, A Lindstrom, S Longenberger, A Lucas, P Lynfield, R McMorrow, M Moll, M Morin, C Ostroff, S Page, SL Park, SY Peters, S Quinn, C Reed, C Richards, S Scheftel, J Simwale, O Shu, B Soyemi, K Stauffer, J Steffens, C Su, S Torso, L Uyeki, TM Vetter, S Villanueva, J Wong, KK Shaw, M Bresee, JS Cox, N Finelli, L AF Jhung, Michael A. Epperson, Scott Biggerstaff, Matthew Allen, Donna Balish, Amanda Barnes, Nathelia Beaudoin, Amanda Berman, LaShondra Bidol, Sally Blanton, Lenee Blythe, David Brammer, Lynnette D'Mello, Tiffany Danila, Richard Davis, William de Fijter, Sietske DiOrio, Mary Durand, Lizette O. Emery, Shannon Fowler, Brian Garten, Rebecca Grant, Yoran Greenbaum, Adena Gubareva, Larisa Havers, Fiona Haupt, Thomas House, Jennifer Ibrahim, Sherif Jiang, Victoria Jain, Seema Jernigan, Daniel Kazmierczak, James Klimov, Alexander Lindstrom, Stephen Longenberger, Allison Lucas, Paul Lynfield, Ruth McMorrow, Meredith Moll, Maria Morin, Craig Ostroff, Stephen Page, Shannon L. Park, Sarah Y. Peters, Susan Quinn, Celia Reed, Carrie Richards, Shawn Scheftel, Joni Simwale, Owen Shu, Bo Soyemi, Kenneth Stauffer, Jill Steffens, Craig Su, Su Torso, Lauren Uyeki, Timothy M. Vetter, Sara Villanueva, Julie Wong, Karen K. Shaw, Michael Bresee, Joseph S. Cox, Nancy Finelli, Lyn TI Outbreak of Variant Influenza A(H3N2) Virus in the United States SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE influenza; outbreak; pandemic; variant influenza ID SWINE INFLUENZA; A H1N1; HUMAN INFECTIONS; COUNTY FAIR; PIGS; TRANSMISSION; VACCINE; HUMANS; FERRETS; RECOMMENDATIONS AB Background. Variant influenza virus infections are rare but may have pandemic potential if person-to-person transmission is efficient. We describe the epidemiology of a multistate outbreak of an influenza A(H3N2) variant virus (H3N2v) first identified in 2011. Methods. We identified laboratory-confirmed cases of H3N2v and used a standard case report form to characterize illness and exposures. We considered illness to result from person-to-person H3N2v transmission if swine contact was not identified within 4 days prior to illness onset. Results. From 9 July to 7 September 2012, we identified 306 cases of H3N2v in 10 states. The median age of all patients was 7 years. Commonly reported signs and symptoms included fever (98%), cough (85%), and fatigue (83%). Sixteen patients (5.2%) were hospitalized, and 1 fatal case was identified. The majority of those infected reported agricultural fair attendance (93%) and/or contact with swine (95%) prior to illness. We identified 15 cases of possible person-to-person transmission of H3N2v. Viruses recovered from patients were 93%-100% identical and similar to viruses recovered from previous cases of H3N2v. All H3N2v viruses examined were susceptible to oseltamivir and zanamivir and resistant to adamantane antiviral medications. Conclusions. In a large outbreak of variant influenza, the majority of infected persons reported exposures, suggesting that swine contact at an agricultural fair was a risk for H3N2v infection. We identified limited person-to-person H3N2v virus transmission, but found no evidence of efficient or sustained person-to-person transmission. Fair managers and attendees should be aware of the risk of swine-to-human transmission of influenza viruses in these settings. C1 [Jhung, Michael A.; Epperson, Scott; Biggerstaff, Matthew; Balish, Amanda; Barnes, Nathelia; Berman, LaShondra; Blanton, Lenee; Brammer, Lynnette; D'Mello, Tiffany; Davis, William; Emery, Shannon; Garten, Rebecca; Gubareva, Larisa; Jiang, Victoria; Jain, Seema; Jernigan, Daniel; Klimov, Alexander; Lindstrom, Stephen; McMorrow, Meredith; Reed, Carrie; Shu, Bo; Steffens, Craig; Su, Su; Uyeki, Timothy M.; Villanueva, Julie; Shaw, Michael; Bresee, Joseph S.; Cox, Nancy; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Durand, Lizette O.; Greenbaum, Adena; Havers, Fiona; Wong, Karen K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Influenza Div, Atlanta, GA 30333 USA. [Quinn, Celia] Ohio Dept Hlth, Epidem Intelligence Serv, Columbus, OH 43266 USA. [Lucas, Paul; Soyemi, Kenneth] Illinois Dept Publ Hlth, Springfield, IL 62761 USA. [Grant, Yoran] Illinois Dept Publ Hlth, Epidem Intelligence Serv, Springfield, IL 62761 USA. [Bidol, Sally; Peters, Susan] Michigan Dept Community Hlth, Lansing, MI USA. [Danila, Richard; Lynfield, Ruth; Morin, Craig; Scheftel, Joni; Vetter, Sara] Minnesota Dept Hlth, St Paul, MN USA. [Allen, Donna; House, Jennifer; Richards, Shawn; Stauffer, Jill] Indiana State Dept Hlth, Indianapolis, IN 46202 USA. [Balish, Amanda] Penn Dept Hlth, Epidem Intelligence Serv, Harrisburg, PA 17108 USA. [Longenberger, Allison; Moll, Maria; Ostroff, Stephen; Simwale, Owen; Torso, Lauren] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Park, Sarah Y.] Hawaii Dept Hlth, Honolulu, HI USA. [de Fijter, Sietske; DiOrio, Mary; Fowler, Brian; Page, Shannon L.] Ohio Dept Hlth, Columbus, OH 43266 USA. [Haupt, Thomas; Kazmierczak, James] Wisconsin Dept Hlth Serv, Madison, WI USA. [Ibrahim, Sherif] West Virginia Bur Publ Hlth, Charleston, SC USA. [Blythe, David] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. RP Jhung, MA (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM mjhung@cdc.gov NR 56 TC 59 Z9 60 U1 3 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2013 VL 57 IS 12 BP 1703 EP 1712 DI 10.1093/cid/cit649 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 262FT UT WOS:000327720400008 PM 24065322 ER PT J AU Magill, SS Klompas, M Balk, R Burns, SM Deutschman, CS Diekema, D Fridkin, S Greene, L Guh, A Gutterman, D Hammer, B Henderson, D Hess, D Hill, NS Horan, T Kollef, M Levy, M Septimus, E VanAntwerpen, C Wright, D Lipsett, P AF Magill, Shelley S. Klompas, Michael Balk, Robert Burns, Suzanne M. Deutschman, Clifford S. Diekema, Daniel Fridkin, Scott Greene, Linda Guh, Alice Gutterman, David Hammer, Beth Henderson, David Hess, Dean Hill, Nicholas S. Horan, Teresa Kollef, Marin Levy, Mitchell Septimus, Edward VanAntwerpen, Carole Wright, Don Lipsett, Pamela TI Developing a New, National Approach to Surveillance for Ventilator-Associated Events: Executive Summary SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE ventilator-associated pneumonia; intensive care unit; epidemiology; public health; critical care; mechanical ventilation C1 [Magill, Shelley S.; Fridkin, Scott; Guh, Alice; Horan, Teresa] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30329 USA. [Klompas, Michael] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA. [Klompas, Michael] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Klompas, Michael] Brigham & Womens Hosp, Infect Control Dept, Boston, MA 02115 USA. [Klompas, Michael] Soc Healthcare Epidemiol Amer, Arlington, VA USA. [Balk, Robert] Rush Univ, Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60612 USA. [Balk, Robert; Burns, Suzanne M.; Deutschman, Clifford S.; Gutterman, David; Hammer, Beth; Hill, Nicholas S.; Kollef, Marin; Levy, Mitchell; Lipsett, Pamela] Crit Care Soc Collaborat Amer Assoc Crit Care Nur, Charlottesville, VA USA. [Burns, Suzanne M.] Univ Virginia, Sch Nursing Crit & Acute Care, Charlottesville, VA USA. [Deutschman, Clifford S.] Univ Penn, Perelman Sch Med, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA. [Diekema, Daniel] Univ Iowa, Carver Coll Med, Div Infect Dis, Iowa City, IA USA. [Diekema, Daniel] Healthcare Infect Control Practices Advisory Comm, Atlanta, GA USA. [Greene, Linda] Rochester Gen Hlth Syst, Infect Prevent & Control Dept, Rochester, NY USA. [Greene, Linda] Assoc Profess Infect Control & Epidemiol, Washington, DC USA. [Gutterman, David] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Hammer, Beth] Zablocki VA Med Ctr, Dept Cardiol, Milwaukee, WI USA. [Henderson, David] NIH, Hosp Epidemiol & Qual Improvement, Ctr Clin, Bethesda, MD 20892 USA. [Hess, Dean] Massachusetts Gen Hosp, Dept Resp Care, Boston, MA 02114 USA. [Hess, Dean] Harvard Univ, Sch Med, Dept Anesthesia, Boston, MA 02115 USA. [Hess, Dean] Amer Assoc Resp Care, Irving, TX USA. [Hill, Nicholas S.] Tufts Med Ctr, Div Pulm & Crit Care Med, Boston, MA USA. [Kollef, Marin] Washington Univ, Div Pulm & Crit Care Med, St Louis, MO USA. [Levy, Mitchell] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep, Providence, RI 02903 USA. [Septimus, Edward] Texas A&M Hlth Sci Ctr, Dept Internal Med, College Stn, TX USA. [Septimus, Edward] Infect Dis Soc Amer, Arlington, VA USA. [VanAntwerpen, Carole] New York State Dept Hlth, Bur Healthcare Associated Infect, Albany, NY USA. [VanAntwerpen, Carole] Council State & Terr Epidemiologists, Atlanta, GA USA. [Wright, Don] US Dept HHS, Off Dis Prevent & Hlth Promot, Washington, DC 20201 USA. [Lipsett, Pamela] Johns Hopkins Univ, Sch Med, Dept Surg Anesthesiol & Crit Care Med, Baltimore, MD USA. RP Magill, SS (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A-24, Atlanta, GA 30329 USA. EM smagill@cdc.gov NR 2 TC 12 Z9 13 U1 1 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2013 VL 57 IS 12 BP 1742 EP 1746 DI 10.1093/cid/cit577 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 262FT UT WOS:000327720400013 PM 24280662 ER PT J AU Wang, LM Kourtis, AP Ellington, S Legardy-Williams, J Bulterys, M AF Wang, Liming Kourtis, Athena P. Ellington, Sascha Legardy-Williams, Jennifer Bulterys, Marc TI Safety of Tenofovir During Pregnancy for the Mother and Fetus: A Systematic Review SO CLINICAL INFECTIOUS DISEASES LA English DT Review DE HIV; PMTCT; TDF; pregnancy; safety ID HEPATITIS-B-VIRUS; SINGLE-DOSE TENOFOVIR; TO-CHILD TRANSMISSION; REVERSE-TRANSCRIPTASE INHIBITORS; PREVENT PERINATAL TRANSMISSION; EXPOSED UNINFECTED INFANTS; DISOPROXIL FUMARATE; MITOCHONDRIAL TOXICITY; PREEXPOSURE PROPHYLAXIS; VERTICAL TRANSMISSION AB Tenofovir disoproxil fumarate (TDF) safety during pregnancy has important public health implications. This review summarizes TDF safety during pregnancy, focusing on pregnancy outcomes, congenital anomaly risk, and other potential toxicities on neonates. Although information is limited, TDF appears to be safe during pregnancy. In 6 studies of human immunodeficiency virus type 1 (and/or hepatitis B virus)-infected women receiving TDF during pregnancy, adverse events were mild to moderate; none were considered to be TDF-related. Five studies that followed in utero TDF-exposed infants showed no increased risk of growth or bone abnormalities. One study showed slightly lower infant height at age 1 year, but the significance is unclear. The Antiretroviral Pregnancy Registry database, with 1800 pregnancies exposed to TDF in the first trimester, does not indicate increased congenital anomaly risk with TDF exposure. More evidence collected prospectively, ideally with bone density measurements and randomized trial design, will be optimal to determine the effects of antenatal TDF exposure on children's health. C1 [Wang, Liming; Bulterys, Marc] US Ctr Dis Control & Prevent, Global AIDS Program, Beijing, Peoples R China. [Kourtis, Athena P.; Ellington, Sascha; Legardy-Williams, Jennifer] US Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Bulterys, Marc] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, 4770 Buford Hwy NE,MS K34, Atlanta, GA 30341 USA. EM apk3@cdc.gov NR 57 TC 23 Z9 24 U1 1 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2013 VL 57 IS 12 BP 1773 EP 1781 DI 10.1093/cid/cit601 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 262FT UT WOS:000327720400019 PM 24046310 ER PT J AU Breiman, RF Van Beneden, CA Farnon, EC AF Breiman, Robert F. Van Beneden, Chris A. Farnon, Eileen C. TI Surveillance for Respiratory Infections in Low- and Middle-Income Countries: Experience From the Centers for Disease Control and Prevention's Global Disease Detection International Emerging Infections Program SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE respiratory infections; surveillance; International Emerging Infections Program ID INFLUENZA-A H1N1; PNEUMONIA; THAILAND; ILLNESS; BURDEN; KENYA; CORONAVIRUS; BANGLADESH; PATHOGENS; CHILDREN C1 [Breiman, Robert F.] US Ctr Dis Control & Prevent, Kenya Off, Global Dis Detect Reg Ctr, Nairobi, Kenya. [Van Beneden, Chris A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA 30333 USA. [Farnon, Eileen C.] Ctr Dis Control & Prevent, Global Dis Detect Branch, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Farnon, EC (reprint author), Ctr Dis Control & Prevent, Global Dis Detect Branch, DGHP CGH, 1600 Clifton Rd NE,MS D-68, Atlanta, GA 30333 USA. EM efarnon@cdc.gov FU Global Disease Detection Program, Centers for Global Health; Influenza Division, National Centers for Immunization and Respiratory Disease at the US Centers for Disease Control and Prevention FX This work was supported by the Global Disease Detection Program, Centers for Global Health, and the Influenza Division, National Centers for Immunization and Respiratory Disease at the US Centers for Disease Control and Prevention. NR 30 TC 3 Z9 3 U1 0 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S167 EP S172 DI 10.1093/infdis/jit462 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900002 PM 24265474 ER PT J AU Fields, BS House, BL Klena, J Waboci, LW Whistler, T Farnon, EC AF Fields, Barry S. House, Brent L. Klena, John Waboci, Lilian W. Whistler, Toni Farnon, Eileen C. TI Role of Global Disease Detection Laboratories in Investigations of Acute Respiratory Illness SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE respiratory infections; laboratory; International Emerging Infections Program ID PATHOGENS C1 [Fields, Barry S.; Waboci, Lilian W.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Nairobi, Kenya. [House, Brent L.] Naval Med Res, Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. [Klena, John] Ctr Dis Control & Prevent, Div Global Hlth Protect, Beijing, Peoples R China. [Whistler, Toni] Ctr Dis Control & Prevent, Div Global Hlth Protect, Bangkok, Thailand. [Farnon, Eileen C.] Ctr Dis Control & Prevent, Ctr Global Hlth, Global Dis Detect Branch, Div Global Hlth Protect, Atlanta, GA 30333 USA. RP Farnon, EC (reprint author), Ctr Dis Control & Prevent, Sci Team, Global Dis Detect Branch, DGHP CGH, 1600 Clifton Rd NE,MS D-68, Atlanta, GA 30333 USA. EM efarnon@cdc.gov FU Global Disease Detection Program, Center for Global Health; Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention FX This work was supported by the Global Disease Detection Program, Center for Global Health, and by the Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention. NR 10 TC 0 Z9 0 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S173 EP S176 DI 10.1093/infdis/jit490 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900003 PM 24265475 ER PT J AU Haynes, AK Manangan, AP Iwane, MK Sturm-Ramirez, K Homaira, N Brooks, WA Luby, S Rahman, M Klena, JD Zhang, YZ Yu, HG Zhan, FX Dueger, E Mansour, AM Azazzy, N McCracken, JP Bryan, JP Lopez, MR Burton, DC Bigogo, G Breiman, RF Feikin, DR Njenga, K Montgomery, J Cohen, AL Moyes, J Pretorius, M Cohen, C Venter, M Chittaganpitch, M Thamthitiwat, S Sawatwong, P Baggett, HC Luber, G Gerber, SI AF Haynes, Amber K. Manangan, Arie P. Iwane, Marika K. Sturm-Ramirez, Katharine Homaira, Nusrat Brooks, W. Abdullah Luby, Stephen Rahman, Mahmudur Klena, John D. Zhang, Yuzhi Yu, Hongie Zhan, Faxian Dueger, Erica Mansour, Adel Mahmoud Azazzy, Nahed McCracken, John P. Bryan, Joe P. Lopez, Maria R. Burton, Deron C. Bigogo, Godfrey Breiman, Robert F. Feikin, Daniel R. Njenga, Kariuki Montgomery, Joel Cohen, Adam L. Moyes, Jocelyn Pretorius, Marthi Cohen, Cheryl Venter, Marietjie Chittaganpitch, Malinee Thamthitiwat, Somsak Sawatwong, Pongpun Baggett, Henry C. Luber, George Gerber, Susan I. TI Respiratory Syncytial Virus Circulation in Seven Countries With Global Disease Detection Regional Centers SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE respiratory tract infections; respiratory syncytial virus infections; climate; seasons; humans ID INFECTIONS; SEASONALITY; DYNAMICS; CLIMATE; TROPICS AB Background. Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children globally, with the highest burden in low-and middle-income countries where the association between RSV activity and climate remains unclear. Methods. Monthly laboratory-confirmed RSV cases and associations with climate data were assessed for respiratory surveillance sites in tropical and subtropical areas (Bangladesh, China, Egypt, Guatemala, Kenya, South Africa, and Thailand) during 2004-2012. Average monthly minimum and maximum temperatures, relative humidity, and precipitation were calculated using daily local weather data from the US National Climatic Data Center. Results. RSV circulated with 1-2 epidemic periods each year in site areas. RSV seasonal timing and duration were generally consistent within country from year to year. Associations between RSV and weather varied across years and geographic locations. RSV usually peaked in climates with high annual precipitation (Bangladesh, Guatemala, and Thailand) during wet months, whereas RSV peaked during cooler months in moderately hot (China) and arid (Egypt) regions. In South Africa, RSV peaked in autumn, whereas no associations with seasonal weather trends were observed in Kenya. Conclusions. Further understanding of RSV seasonality in developing countries and various climate regions will be important to better understand the epidemiology of RSV and for timing the use of future RSV vaccines and immunoprophylaxis in low- and middle-income countries. C1 [Haynes, Amber K.; Iwane, Marika K.; Montgomery, Joel] Johns Hopkins Univ, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Baltimore, MD USA. [Manangan, Arie P.; Cohen, Adam L.; Luber, George] Johns Hopkins Univ, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Baltimore, MD USA. [Sturm-Ramirez, Katharine; Montgomery, Joel] Johns Hopkins Univ, Natl Ctr Immunizat & Resp Dis, Influenza Div, Baltimore, MD USA. [Sturm-Ramirez, Katharine; Homaira, Nusrat; Brooks, W. Abdullah; Luby, Stephen] Johns Hopkins Univ, Int Ctr Diarrhoeal Dis Res Bangladesh, Ctr Communicable Dis, Baltimore, MD USA. [Brooks, W. Abdullah] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Klena, John D.] Global Dis Detect Ctr, Beijing, Peoples R China. [Zhang, Yuzhi] Hubei Prov Ctr Dis Control, Div HIV AIDS, Wuhan, Hubei, Peoples R China. [Yu, Hongie; Dueger, Erica] Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. [Mansour, Adel Mahmoud] Naval Med Res Unit 3, Bacterial & Parasit Dis Res Program, Div Bacterial Dis, Cairo, Egypt. [Azazzy, Nahed] Minist Hlth & Populat, Int Emerging Infect Program, Cairo, Egypt. [McCracken, John P.; Bryan, Joe P.; Lopez, Maria R.] Univ Valle Guatemala, Ctr Hlth Studies, Guatemala City, Guatemala. [Bigogo, Godfrey; Njenga, Kariuki] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Nairobi, Kenya. Ctr Dis Control & Prevent, Hlth Off 1, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Program, Johannesburg, South Africa. [Moyes, Jocelyn; Pretorius, Marthi; Cohen, Cheryl; Venter, Marietjie] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa. [Venter, Marietjie] Univ Pretoria, Dept Med Virol, ZA-0001 Pretoria, South Africa. [Chittaganpitch, Malinee] MOPH, Natl Inst Hlth, Nonthaburi, Thailand. RP Haynes, AK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS A-34, Atlanta, GA 30333 USA. EM ahaynes1@cdc.gov RI Venter, Marietjie/P-9604-2016; OI Venter, Marietjie/0000-0003-2696-824X; Luby, Stephen/0000-0001-5385-899X FU Centers for Disease Control and Prevention; Center for Global Health; Division of Global Health Protection; National Center for Immunization and Respiratory Diseases, Influenza Division FX This work was supported by the Centers for Disease Control and Prevention, Center for Global Health, Division of Global Health Protection and the National Center for Immunization and Respiratory Diseases, Influenza Division. NR 32 TC 30 Z9 31 U1 2 U2 16 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S246 EP S254 DI 10.1093/infdis/jit515 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900012 PM 24265484 ER PT J AU Haynes, LM AF Haynes, Lia M. TI Progress and Challenges in RSV Prophylaxis and Vaccine Development SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RESPIRATORY SYNCYTIAL VIRUS; YOUNG-CHILDREN; MONOCLONAL-ANTIBODY; EPITHELIAL-CELLS; G-PROTEIN; INFECTION; INFANTS; FUSION; CANDIDATE; IMMUNOGENICITY C1 [Haynes, Lia M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. RP Haynes, LM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,A-34, Atlanta, GA 30333 USA. EM loh5@cdc.gov NR 54 TC 14 Z9 14 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S177 EP S183 DI 10.1093/infdis/jit512 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900004 PM 24265476 ER PT J AU Huo, XX Fang, B Liu, LL Yu, HJ Chen, H Zheng, JD Zhang, YZ Xu, Z Klena, JD Varma, JK Peng, ZB Xing, XS Xuhua, G Zhan, FX AF Huo, Xixiang Fang, Bin Liu, Linlin Yu, Hongjie Chen, Hui Zheng, Jiandong Zhang, Yuzhi Xu, Zhen Klena, John D. Varma, Jay K. Peng, Zhibin Xing, Xuesen Xuhua, Guan Zhan, Faxian TI Clinical and Epidemiologic Characteristics of Respiratory Syncytial Virus Infection Among Children Aged < 5 Years, Jingzhou City, China, 2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE RSV; seasonal distribution; Hubei ID TRACT INFECTIONS; DISEASE AB Severe acute respiratory illness (SARI) surveillance began in Jingzhou City, China, in 2010. A subset of 511 children aged <5 years enrolled in the SARI study during 2011 were tested for influenza and noninfluenza respiratory viral infection by real-time reverse-transcription polymerase chain reaction. Respiratory syncytial virus (RSV) was most commonly detected. Children aged 12-23 and 24-60 months were equally likely to test positive for RSV. Although cases of RSV infection could be detected throughout the year, the greatest numbers were detected from autumn to early winter. C1 [Huo, Xixiang; Fang, Bin; Liu, Linlin; Chen, Hui; Xing, Xuesen; Xuhua, Guan; Zhan, Faxian] Hubei Prov Dis Prevent & Control Ctr, Wuhan, Peoples R China. [Yu, Hongjie; Zheng, Jiandong; Xu, Zhen; Peng, Zhibin] Ctr Dis Control & Prevent, Beijing, Peoples R China. [Zhang, Yuzhi; Klena, John D.; Varma, Jay K.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Klena, JD (reprint author), Ctr Dis Control & Prevent, Emerging Infect Program, China Off, Sect 7300 Box 060, DPO, AP 96521 USA. EM irc4@cn.cdc.gov FU Division of Global Disease Detection and Emergency Response; Center for Global Health; Centers for Disease Control and Prevention FX This work was supported by the Division of Global Disease Detection and Emergency Response, Center for Global Health, Centers for Disease Control and Prevention. NR 15 TC 1 Z9 3 U1 1 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S184 EP S188 DI 10.1093/infdis/jit518 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900005 PM 24265477 ER PT J AU Iwane, MK Farnon, EC Gerber, SI AF Iwane, Marika K. Farnon, Eileen C. Gerber, Susan I. TI Importance of Global Surveillance for Respiratory Syncytial Virus SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material DE respiratory syncytial virus; respiratory infections; international ID INFECTION; ADULTS C1 [Iwane, Marika K.; Gerber, Susan I.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. [Farnon, Eileen C.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA 30333 USA. RP Iwane, MK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,NE,MS A-34, Atlanta, GA 30333 USA. EM miwane@cdc.gov NR 5 TC 2 Z9 3 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S165 EP S166 DI 10.1093/infdis/jit484 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900001 PM 24265473 ER PT J AU McCracken, JP Prill, MM Arvelo, W Lindblade, KA Lopez, MR Estevez, A Muller, ML Munoz, F Bernart, C Cortez, M Moir, JC Ortiz, J Paredes, A Iwane, MK AF McCracken, John P. Prill, Mila M. Arvelo, Wences Lindblade, Kim A. Lopez, Maria R. Estevez, Alejandra Muller, Maria L. Munoz, Fredy Bernart, Christopher Cortez, Margarita Moir, Juan C. Ortiz, Jose Paredes, Antonio Iwane, Marika K. TI Respiratory Syncytial Virus Infection in Guatemala, 2007-2012 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE acute respiratory illness; epidemiology; respiratory syncytial virus; severity; surveillance ID HIGH-RISK ADULTS; YOUNG-CHILDREN; INFLUENZA-VIRUS; OLDER-ADULTS; PNEUMONIA; BURDEN; BRONCHIOLITIS; POPULATION; DISEASE; HOSPITALIZATIONS AB Background. Respiratory syncytial virus (RSV) is a major cause of acute respiratory illness (ARI). Little is known about RSV disease among older children and adults in Central America. Methods. Prospective surveillance for ARI among hospital patients and clinic patients was conducted in Guatemala during 2007-2012. Nasopharyngeal and oropharyngeal swab specimens were tested for RSV, using real-time reverse-transcription polymerase chain reaction. Results. Of 6287 hospitalizations and 2565 clinic visits for ARI, 24% and 12%, respectively, yielded RSV-positive test results. The incidence of RSV-positive hospitalization for ARI was 5.8 cases/10 000 persons per year and was highest among infants aged <6 months (208 cases/10 000 persons per year); among adults, the greatest incidence was observed among those aged >= 65 years (2.9 cases/10 000 persons per year). The incidence of RSV-positive clinic visitation for ARI was 32 cases/10 000 persons per year and was highest among infants aged 6-23 months (186 cases/10 000 persons per year). Among RSV-positive hospital patients with ARI, underlying cardiovascular disease was associated with death, moribund discharge, intensive care unit admission, or mechanical ventilation (odds ratio, 4.1; 95% confidence interval, 1.9-8.8). The case-fatality proportion among RSV-positive hospital patients with ARI was higher for those aged >= 5 years than for those aged <5 years (13% vs 3%; P < .001). Conclusions. The incidences of RSV-associated hospitalization and clinic visitation for ARI were highest among young children, but a substantial burden of ARI due to RSV was observed among older children and adults. C1 [McCracken, John P.; Lopez, Maria R.; Estevez, Alejandra; Muller, Maria L.; Munoz, Fredy; Bernart, Christopher] Univ Valle Guatemala, Ctr Hlth Studies, Guatemala City, Guatemala. [Cortez, Margarita; Moir, Juan C.; Paredes, Antonio] Minist Publ Hlth & Social Welf, Guatemala City, Guatemala. [Ortiz, Jose] Guatemalan Social Secur Inst, Guatemala City, Guatemala. [Prill, Mila M.; Iwane, Marika K.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. [Arvelo, Wences; Lindblade, Kim A.] Ctr Dis Control & Prevent, Div Global Dis Detect & Emergency Response, Atlanta, GA USA. RP McCracken, JP (reprint author), Univ Valle Guatemala, Ctr Hlth Studies, 18 Ave 11-95,Zona 15,VH 3, Guatemala City, Guatemala. EM jmccracken@ces.uvg.edu.gt FU Centers for Disease Control's Global Disease Detection and Emerging Infections; Universidad del Valle de Guatemala [1U01GH000028-03] FX This work was supported by the Centers for Disease Control's Global Disease Detection and Emerging Infections appropriations through a cooperative agreement with the Universidad del Valle de Guatemala (1U01GH000028-03). NR 33 TC 5 Z9 5 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S197 EP S206 DI 10.1093/infdis/jit517 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900007 PM 24265479 ER PT J AU Moyes, J Cohen, C Pretorius, M Groome, M von Gottberg, A Wolter, N Walaza, S Haffejee, S Chhagan, M Naby, F Cohen, AL Tempia, S Kahn, K Dawood, H Venter, M Madhi, SA AF Moyes, Jocelyn Cohen, Cheryl Pretorius, Marthi Groome, Michelle von Gottberg, Anne Wolter, Nicole Walaza, Sibongile Haffejee, Sumayya Chhagan, Meera Naby, Fathima Cohen, Adam L. Tempia, Stefano Kahn, Kathleen Dawood, Halima Venter, Marietjie Madhi, Shabir A. CA South African Severe Acute Resp Il TI Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection Hospitalizations Among HIV-Infected and HIV-Uninfected South African Children, 2010-2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SERIOUS BACTERIAL-INFECTIONS; INFANTS; BURDEN; RISK AB Background. There are limited data on respiratory syncytial virus (RSV) infection among children in settings with a high prevalence of human immunodeficiency virus (HIV). We studied the epidemiology of RSV-associated acute lower respiratory tract infection (ALRTI) hospitalizations among HIV-infected and HIV-uninfected children in South Africa. Methods. Children aged <5 years admitted to sentinel surveillance hospitals with physician-diagnosed neonatal sepsis or ALRTI were enrolled. Nasopharyngeal aspirates were tested by multiplex real-time polymerase chain reaction assays for RSV and other viruses. Associations between possible risk factors and severe outcomes for RSV infection among HIV-infected and uninfected children were examined. The relative risk of hospitalization in HIV-infected and HIV-uninfected children was calculated in 1 site with population denominators. Results. Of 4489 participants, 4293 (96%) were tested for RSV, of whom 1157 (27%) tested positive. With adjustment for age, HIV-infected children had a 3-5-fold increased risk of hospitalization with RSV-associated ALRTI (2010 relative risk, 5.6; [95% confidence interval (CI), 4.5-6.4]; 2011 relative risk, 3.1 [ 95% CI, 2.6-3.6]). On multivariable analysis, HIV-infected children with RSV-associated ALRTI had higher odds of death (adjusted odds ratio. 31.1; 95% CI, 5.4-179.8) and hospitalization for >5 days (adjusted odds ratio, 4.0; 95% CI, 1.5-10.6) than HIV-uninfected children. Conclusion. HIV-infected children have a higher risk of hospitalization with RSV-associated ALRTI and a poorer outcome than HIV-uninfected children. These children should be targeted for interventions aimed at preventing severe RSV disease. C1 [Moyes, Jocelyn; Cohen, Cheryl; Pretorius, Marthi; von Gottberg, Anne; Wolter, Nicole; Walaza, Sibongile; Tempia, Stefano; Venter, Marietjie; Madhi, Shabir A.] Univ Witwatersrand, Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. [Moyes, Jocelyn; Cohen, Cheryl] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Groome, Michelle; Madhi, Shabir A.] Univ Witwatersrand, Natl Res Fdn Vaccine Preventable Dis, Med Res Council, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Groome, Michelle; Madhi, Shabir A.] Univ Witwatersrand, Natl Res Fdn Vaccine Preventable Dis, Dept Sci & Technol, Johannesburg, South Africa. [Haffejee, Sumayya; Chhagan, Meera; Naby, Fathima; Dawood, Halima] Pietermaritzburg Hosp Complex, Pretoria, South Africa. [Haffejee, Sumayya; Chhagan, Meera; Naby, Fathima; Dawood, Halima] Univ KwaZulu Natal, Pretoria, South Africa. [Cohen, Adam L.; Tempia, Stefano] Ctr Dis Control & Prevent, Influenza Program, Pretoria, South Africa. [Cohen, Adam L.; Tempia, Stefano] Ctr Dis Control & Prevent, Influenza Program, Atlanta, GA USA. [Kahn, Kathleen] Umea Univ, S-90187 Umea, Sweden. [Kahn, Kathleen] INDEPTH network, Accra, Ghana. RP Moyes, J (reprint author), Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM jocelynm@nicd.ac.za RI Venter, Marietjie/P-9604-2016; OI Venter, Marietjie/0000-0003-2696-824X; Pretorius, Marthi/0000-0003-2163-6158 FU Centers for Disease Control and Prevention [5U51IP000155, 1U51IP000528] FX The Severe Acute Respiratory Illness surveillance program has been funded through 2 grants from the Centers for Disease Control and Prevention, namely, South African Preparedness for Rapid Detection of Highly Pathogenic Avian Influenza (grant 5U51IP000155) and Sustaining Surveillance Networks and Response to Seasonal Influenza (grant 1U51IP000528). NR 25 TC 21 Z9 21 U1 1 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S217 EP S226 DI 10.1093/infdis/jit479 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900009 PM 24265481 ER PT J AU Naorat, S Chittaganpitch, M Thamthitiwat, S Henchaichon, S Sawatwong, P Srisaengchai, P Lu, Y Chuananon, S Amornintapichet, T Chantra, S Erdman, DD Maloney, SA Akarasewi, P Baggett, HC AF Naorat, Sathapana Chittaganpitch, Malinee Thamthitiwat, Somsak Henchaichon, Sununta Sawatwong, Pongpun Srisaengchai, Prasong Lu, Ying Chuananon, Somchai Amornintapichet, Tussanee Chantra, Somrak Erdman, Dean D. Maloney, Susan A. Akarasewi, Passakorn Baggett, Henry C. TI Hospitalizations for Acute Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Thailand, 2008-2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE respiratory syncytial virus; acute lower respiratory infection; Thailand ID RURAL THAILAND; PNEUMONIA; SURVEILLANCE AB Background. Few population-based estimates of the incidence of respiratory syncytial virus (RSV) infection in low-or middle-income countries are available. We describe the incidence and epidemiology of hospitalizations for RSV-associated acute lower respiratory tract infection (ALRI) detected by active population-based surveillance in 2 rural Thailand provinces during 2008-2011. Methods. Patients hospitalized with ALRI were systematically sampled. Consenting patients provided nasopharyngeal swab specimens for RSV testing by real-time reverse-transcription polymerase chain reaction. Results. Of 13 982 enrolled patients hospitalized with ALRI, 1137 (8.1%) were RSV positive. After adjustment for sampling and nonenrollment, the incidence of RSV-associated ALRI hospitalization was 85 cases per 100 000 persons/year. The highest rates occurred among children aged <5 years (981 cases per 100 000 persons/year) and <1 year (1543 cases per 100 000 persons/year). Rates were low among older children and young adults but high among persons aged >65 years (130 cases per 100 000 persons/year). Eight (0.7%) RSV-infected study patients died during hospitalization. Annual RSV hospitalizations peaked during July-October with almost no documented RSV hospitalizations during January-June. Conclusions. Our findings demonstrate the substantial contribution of RSV to global ALRI burden, especially in children aged <5 years and the elderly, and underscore the urgent need for effective prevention measures. C1 [Naorat, Sathapana; Thamthitiwat, Somsak; Henchaichon, Sununta; Sawatwong, Pongpun; Srisaengchai, Prasong; Lu, Ying; Maloney, Susan A.; Baggett, Henry C.] Thailand Minist Publ Hlth MOPH, US Ctr Dis Control & Prevent Collaborat, Global Dis Detect Reg Ctr, Int Emerging Infect Program, Muang, Nothanburi, Thailand. [Chittaganpitch, Malinee] MOPH, Natl Inst Hlth, Nonthaburi, Thailand. [Akarasewi, Passakorn] MOPH, Bur Epidemiol, Nonthaburi, Thailand. [Erdman, Dean D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Baggett, Henry C.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Atlanta, GA USA. RP Baggett, HC (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, Int Emerging Infect Program, DDC7 Bldg,3rd Fl,Soi 4,Tivanon Rd, Muang 11000, Nonthaburi, Thailand. EM kipb@th.cdc.gov FU Global Disease Detection Program of the US Centers for Disease Control and Prevention FX This work was supported by the Global Disease Detection Program of the US Centers for Disease Control and Prevention. NR 24 TC 7 Z9 7 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S238 EP S245 DI 10.1093/infdis/jit456 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900011 PM 24265483 ER PT J AU Rowlinson, E Dueger, E Taylor, T Mansour, A Van Beneden, C Abukela, M Zhang, XY Refaey, S Bastawy, H Kandeel, A AF Rowlinson, Emily Dueger, Erica Taylor, Thomas Mansour, Adel Van Beneden, Chris Abukela, Mohamed Zhang, Xingyou Refaey, Samir Bastawy, Hesham Kandeel, Amr TI Incidence and Clinical Features of Respiratory Syncytial Virus Infections in a Population-Based Surveillance Site in the Nile Delta Region SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE respiratory syncytial virus; incidence; population-based surveillance ID YOUNG-CHILDREN; HOSPITALIZATIONS; BRONCHIOLITIS; BURDEN; RSV AB Background. Most reports about respiratory syncytial virus (RSV) in developing countries rely on sentinel surveillance, from which population incidence is difficult to infer. We used the proportion of RSV infections from population-based surveillance with data from a healthcare utilization survey to produce estimates of RSV incidence in Damanhour district, Egypt. Methods. We conducted population-based surveillance in 3 hospitals (2009-2012) and 3 outpatient clinics (2011-2012) in Damanhour district. Nasopharyngeal and oropharyngeal specimens from hospitalized patients with acute respiratory illness and outpatients with influenza-like illness were tested by real-time reverse transcriptase polymerase chain reaction for RSV. We also conducted a healthcare utilization survey in 2011-2012 to determine the proportion of individuals who sought care for respiratory illness. Results. Among 5342 hospitalized patients and 771 outpatients, 12% and 5% tested positive for RSV, respectively. The incidence of RSV-associated hospitalization and outpatient visits was estimated at 24 and 608 (per 100 000 person-years), respectively. Children aged <1 year experienced the highest incidence of RSV-associated hospitalizations (1745/100 000 person-years). Conclusions. This study demonstrates the utility of combining a healthcare utilization survey and population-based surveillance data to estimate disease incidence. Estimating incidence and outcomes of RSV disease is critical to establish the burden of RSV in Egypt. C1 [Rowlinson, Emily; Dueger, Erica] US Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. [Dueger, Erica] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA USA. [Taylor, Thomas; Van Beneden, Chris] Ctr Dis Control & Prevent, Resp Dis Branch, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Mansour, Adel] Naval Med Res Unit 3, Bacterial & Parasit Dis Res Program, Div Bacterial Dis, Cairo, Egypt. [Abukela, Mohamed] Minist Hlth & Populat, Int Emerging Infect Program, Cairo, Egypt. [Zhang, Xingyou] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA USA. [Refaey, Samir; Bastawy, Hesham; Kandeel, Amr] Minist Hlth & Populat, Cairo, Egypt. RP Rowlinson, E (reprint author), US Naval Med Res Unit 3, Global Dis Detect & Response Program, 1209 Payne Ave, Austin, TX 78757 USA. EM emily.rowlinson@gmail.com FU CDC; Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance Program FX This work was supported by the CDC and the Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance Program. NR 21 TC 8 Z9 8 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 SU 3 BP S189 EP S196 DI 10.1093/infdis/jit457 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RV UT WOS:000327544900006 PM 24265478 ER PT J AU Smith, BD Jewett, A Burt, RD Zibbell, JE Yartel, AK DiNenno, E AF Smith, Bryce D. Jewett, Amy Burt, Richard D. Zibbell, Jon E. Yartel, Anthony K. DiNenno, Elizabeth TI "To Share or Not to Share?" Serosorting by Hepatitis C Status in the Sharing of Drug Injection Equipment Among NHBS-IDU2 Participants SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE hepatitis C virus; serosorting; injection drug use; sharing injection equipment ID VIRUS-INFECTION; HIV-INFECTION; RISK BEHAVIOR; UNITED-STATES; USERS; PREVALENCE; SURVEILLANCE; POPULATION; MEN AB Background. Persons who inject drugs (PWID) are at high risk for acquiring hepatitis C virus (HCV) infection. The Centers for Disease Control and Prevention estimates there are 17 000 new infections per year, mainly among PWID. This study examines injection equipment serosorting-considering HCV serostatus when deciding whether and with whom to share injection equipment. Objective. To examine whether injection equipment serosorting is occurring among PWID in selected cities. Methods. Using data from the National HIV Behavioral Surveillance System-Injection Drug Users (NHBS-IDU2, 2009), we developed multivariate logistic regression models to examine the extent to which participants' self-reported HCV status is associated with their injection equipment serosorting behavior and knowledge of last injecting partner's HCV status. Results. Participants who knew their HCV status were more likely to know the HCV status of their last injecting partner, compared to those who did not know their status (HCV+: adjusted odds ratio [aOR] 4.1, 95% confidence interval [CI], 3.4-4.9; HCV-: aOR 2.5, 95% CI, 2.0-3.0). Participants who reported being HCV+, relative to those of unknown HCV status, were 5 times more likely to share injection equipment with a partner of HCV-positive status (aOR 4.8, 95% CI, 3.9-6.0). Conclusions. Our analysis suggests PWID are more likely to share injection equipment with persons of concordant HCV status. C1 [Smith, Bryce D.; Zibbell, Jon E.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Jewett, Amy] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Burt, Richard D.] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Yartel, Anthony K.] Ctr Dis Control & Prevent Fdn, Atlanta, GA USA. [DiNenno, Elizabeth] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Smith, BD (reprint author), 1600 Clifton Rd,MS G-37, Atlanta, GA 30333 USA. EM bsmith6@cdc.gov OI Yartel, Anthony/0000-0001-6586-9362 FU Division of Viral Hepatitis at the Centers for Disease Control and Prevention; Division of HIV/AIDS Prevention at the Centers for Disease Control and Prevention FX Funding for this study was provided by Divisions of Viral Hepatitis and HIV/AIDS Prevention at the Centers for Disease Control and Prevention. NR 37 TC 7 Z9 7 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 IS 12 BP 1934 EP 1942 DI 10.1093/infdis/jit520 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RS UT WOS:000327544600003 PM 24136794 ER PT J AU Barskey, AE Juieng, P Whitaker, BL Erdman, DD Oberste, MS Chern, SWW Schmid, DS Radford, KW McNall, RJ Rota, PA Hickman, CJ Bellini, WJ Wallace, GS AF Barskey, Albert E. Juieng, Phalasy Whitaker, Brett L. Erdman, Dean D. Oberste, M. Steven Chern, Shur-Wern Wang Schmid, D. Scott Radford, Kay W. McNall, Rebecca J. Rota, Paul A. Hickman, Carole J. Bellini, William J. Wallace, Gregory S. TI Viruses Detected Among Sporadic Cases of Parotitis, United States, 2009-2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE mumps; parotitis; diagnostics ID REAL-TIME PCR; MUMPS OUTBREAK; VACCINE EFFECTIVENESS; UNIVERSITY-STUDENTS; ENZYME-IMMUNOASSAY; PARA-INFLUENZA; INFECTIONS; CHILDREN; RUBELLA; MEASLES AB Background. Sporadic cases of parotitis are generally assumed to be mumps, which often requires a resource-intensive public health response. This project surveyed the frequency of viruses detected among such cases. Methods. During 2009-2011, 8 jurisdictions throughout the United States investigated sporadic cases of parotitis. Epidemiologic information, serum, and buccal and oropharyngeal swabs were collected. Polymerase chain reaction methods were used to detect a panel of viruses. Anti-mumps virus immunoglobulin M (IgM) antibodies were detected using a variety of methods. Results. Of 101 specimens, 38 were positive for a single virus: Epstein-Barr virus (23), human herpesvirus (HHV)-6B (10), human parainfluenza virus (HPIV)-2 (3), HPIV-3 (1), and human bocavirus (1). Mumps virus, enteroviruses (including human parechovirus), HHV-6A, HPIV-1, and adenoviruses were not detected. Early specimen collection did not improve viral detection rate. Mumps IgM was detected in 17% of available specimens. Patients in whom a virus was detected were younger, but no difference was seen by sex or vaccination profile. No seasonal patterns were identified. Conclusions. Considering the timing of specimen collection, serology results, patient vaccination status, and time of year may be helpful in assessing the likelihood that a sporadic case of parotitis without laboratory confirmation is mumps. C1 [Barskey, Albert E.; Whitaker, Brett L.; Erdman, Dean D.; Oberste, M. Steven; Chern, Shur-Wern Wang; Schmid, D. Scott; Radford, Kay W.; McNall, Rebecca J.; Rota, Paul A.; Hickman, Carole J.; Bellini, William J.; Wallace, Gregory S.] Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. [Juieng, Phalasy] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Atlanta, GA 30333 USA. RP Barskey, AE (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS E-47, Atlanta, GA 30333 USA. EM abarskey@cdc.gov FU public health surveillance by the CDC FX This work was supported as public health surveillance by the CDC. NR 47 TC 3 Z9 4 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2013 VL 208 IS 12 BP 1979 EP 1986 DI 10.1093/infdis/jit408 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 259RS UT WOS:000327544600008 PM 23935203 ER PT J AU Ursem, C Fleming, ST Sabatino, S Wu, XC Wilson, JF Lipscomb, J Cress, R Anderson, R Kimmick, G AF Ursem, C. Fleming, S. T. Sabatino, S. Wu, X-C Wilson, J. F. Lipscomb, J. Cress, R. Anderson, R. Kimmick, G. TI Does socioeconomic status (SES) influence receipt of guideline concordant care in older women with breast cancer: Findings from a Centers for Disease Control and Prevention national program of cancer registries (NPCR) patterns of care study SO CANCER RESEARCH LA English DT Meeting Abstract C1 Duke Univ, Med Ctr, Durham, NC USA. Univ Kentucky, Coll Publ Hlth, Lexington, KY USA. Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. Rollins Sch Publ Hlth, Atlanta, GA USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Med Coll Wisconsin, Milwaukee, WI 53226 USA. UC Davis Sch Med, Sacramento, CA USA. Penn State Coll Med, Hershey, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2013 VL 73 SU 24 MA P1-09-05 DI 10.1158/0008-5472.SABCS13-P1-09-05 PG 2 WC Oncology SC Oncology GA V40RY UT WOS:000209496900218 ER PT J AU Ogilvie, GS Smith, LW van Niekerk, DJ Khurshed, F Krajden, M Saraiya, M Goel, V Rimer, BK Greene, SB Hobbs, S Coldman, AJ Franco, EL AF Ogilvie, Gina S. Smith, Laurie W. van Niekerk, Dirk J. Khurshed, Fareeza Krajden, Mel Saraiya, Mona Goel, Vivek Rimer, Barbara K. Greene, Sandra B. Hobbs, Suzanne Coldman, Andrew J. Franco, Eduardo L. TI Women's intentions to receive cervical cancer screening with primary human papillomavirus testing SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE HPV; cervical cancer screening; intention; theory of planned behavior ID RANDOMIZED CONTROLLED-TRIAL; LIQUID-BASED CYTOLOGY; INTRAEPITHELIAL NEOPLASIA; CONVENTIONAL CYTOLOGY; PLANNED BEHAVIOR; FOLLOW-UP; HPV; KNOWLEDGE; ATTITUDES; IMPACT AB We explored the potential impact of human papillomavirus (HPV) testing on women's intentions to be screened for cervical cancer in a cohort of Canadian women. Participants aged 25-65 years from an ongoing trial were sent a questionnaire to assess women's intentions to be screened for cervical cancer with HPV testing instead of Pap smears and to be screened every 4 years or after 25 years of age. We created scales for attitudes about HPV testing, perceived behavioral control, and direct and indirect subjective norms. Demographic data and scales that were significantly different (p < 0.1) between women who intended to be screened with HPV and those who did not intend were included in a stepwise logistic regression model. Of the 2,016 invitations emailed, 1,538 were received, and 981 completed surveys for a response rate of 63% (981/1,538). Eighty-four percent of women (826/981) responded that they intended to attend for HPV-based cervical cancer screening, which decreased to 54.2% when the screening interval was extended, and decreased further to 51.4% when screening start was delayed to age of 25. Predictors of intentions to undergo screening were attitudes (odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.15, 1.30), indirect subjective norms (OR: 1.02; 95% CI: 1.01, 1.03) and perceived behavioral control (OR: 1.16; 95% CI: 1.10; 1.22). Intentions to be screened for cervical cancer with HPV testing decreased substantially when the screening interval was extended and screening started at age of 25. Use of primary HPV testing may optimize the screening paradigm, but programs should ensure robust planning and education to mitigate any negative impact on screening attendance rates. C1 [Ogilvie, Gina S.; Krajden, Mel] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 4R4, Canada. [Ogilvie, Gina S.; Krajden, Mel] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 4R4, Canada. [Ogilvie, Gina S.; Krajden, Mel] British Columbia Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada. [Smith, Laurie W.; van Niekerk, Dirk J.; Khurshed, Fareeza; Coldman, Andrew J.] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada. [Saraiya, Mona] Ctr Dis Control & Prevent, Atlanta, GA USA. [Goel, Vivek] Publ Hlth Ontario, Toronto, ON, Canada. [Rimer, Barbara K.; Greene, Sandra B.; Hobbs, Suzanne] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Franco, Eduardo L.] McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada. RP Ogilvie, GS (reprint author), Univ British Columbia, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada. EM gina.ogilvie@bccdc.ca OI Goel, Vivek/0000-0002-1389-2007; Franco, Eduardo/0000-0002-4409-8084 FU Canadian Foundation for Women's Health FX Grant sponsor: The Canadian Foundation for Women's Health NR 45 TC 4 Z9 5 U1 1 U2 41 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7136 EI 1097-0215 J9 INT J CANCER JI Int. J. Cancer PD DEC 15 PY 2013 VL 133 IS 12 BP 2934 EP 2943 DI 10.1002/ijc.28324 PG 10 WC Oncology SC Oncology GA 233JW UT WOS:000325565600018 PM 23754203 ER PT J AU McAfee, T Davis, KC Alexander, RL Pechacek, TF Bunnell, R AF McAfee, Tim Davis, Kevin C. Alexander, Robert L., Jr. Pechacek, Terry F. Bunnell, Rebecca TI Effect of the first federally funded US antismoking national media campaign SO LANCET LA English DT Article ID SMOKING-CESSATION; UNITED-STATES; COST-EFFECTIVENESS; TOBACCO CAMPAIGN; QUIT ATTEMPTS; INTERNET; SMOKERS; PREVALENCE; ABSTINENCE; ACCURACY AB Background Every year, smoking kills more than 5 million people globally, including 440 000 people in the USA, where the long-term decline in smoking prevalence has slowed. The US Centers for Disease Control and Prevention (CDC) delivered a national, 3-month antismoking campaign called Tips From Former Smokers (Tips) that started in March, 2012, in which hard-hitting, emotionally evocative television advertising was featured, depicting smoking-related suffering in real people. We aimed to assess the effects of the Tips campaign. Methods We undertook baseline and follow-up surveys of nationally representative cohorts of adult smokers and nonsmokers. The national effect of the Tips campaign was estimated by applying rates of change in the cohort before and after the campaign to US census data. Findings 3051 smokers and 2220 non-smokers completed baseline and follow-up assessments. 2395 (78%) smokers and 1632 (74%) non-smokers recalled seeing at least one Tips advertisement on television during the 3-month campaign. Quit attempts among smokers rose from 31.1% (95% CI 30.3-31.9) at baseline to 34.8% (34.0-35.7) at follow-up, a 12% relative increase. The prevalence of abstinence at follow-up among smokers who made a quit attempt was 13.4% (95% CI 9.7-17.2). Nationally, an estimated 1.64 million additional smokers made a quit attempt, and 220 000 (95% CI 159 000-282 000) remained abstinent at follow-up. Recommendations by non-smokers to quit grew from 2.6% at baseline to 5.1% at follow-up, and the prevalence of people talking with friends and family about the dangers of smoking rose from 31.9% (95% CI 31.3-32.5) to 35.2% (34.6-35.9), resulting in an estimated 4.7 million additional non-smokers recommending cessation services and more than 6 million talking about the dangers of smoking. Interpretation The high-exposure Tips media campaign was effective at increasing population-level quit attempts. The growth in smokers who quit and became sustained quitters could have added from a third to almost half a million quality-adjusted life-years to the US population. Expanded implementation of similar campaigns globally could accelerate progress on the WHO Framework Convention on Tobacco Control and reduce smoking prevalence globally. C1 [McAfee, Tim; Alexander, Robert L., Jr.; Pechacek, Terry F.; Bunnell, Rebecca] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Davis, Kevin C.] RTI Int, Res Triangle Pk, NC USA. RP McAfee, T (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. EM mtt4@cdc.gov FU CDC; US Department of Health and Human Services FX Funding CDC, US Department of Health and Human Services. NR 40 TC 72 Z9 72 U1 1 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD DEC 14 PY 2013 VL 382 IS 9909 BP 2003 EP 2011 DI 10.1016/S0140-6736(13)61686-4 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 269EI UT WOS:000328223700027 PM 24029166 ER PT J AU Ray, G Schulz, T Daniels, W Daly, ER Andrew, TA Brown, CM Cummings, P Nelson, R Cartter, ML Backenson, PB White, JL Kurpiel, PM Rockwell, R Rotans, AS Hertzog, C Squires, LS Linden, JV Prial, M House, J Pontones, P Batten, B Blau, D DeLeon-Carnes, M Muehlenbachs, A Ritter, J Sanders, J Zaki, SR Mead, P Hinckley, A Nelson, C Perea, A Schriefer, M Molins, C Forrester, JD AF Ray, Gregory Schulz, Thadeus Daniels, Wayne Daly, Elizabeth R. Andrew, Thomas A. Brown, Catherine M. Cummings, Peter Nelson, Randall Cartter, Matthew L. Backenson, P. Bryon White, Jennifer L. Kurpiel, Philip M. Rockwell, Russell Rotans, Andrew S. Hertzog, Christen Squires, Linda S. Linden, Jeanne V. Prial, Margaret House, Jennifer Pontones, Pam Batten, Brigid Blau, Dianna DeLeon-Carnes, Marlene Muehlenbachs, Atis Ritter, Jana Sanders, Jeanine Zaki, Sherif R. Mead, Paul Hinckley, Alison Nelson, Christina Perea, Anna Schriefer, Martin Molins, Claudia Forrester, Joseph D. TI Three Sudden Cardiac Deaths Associated with Lyme Carditis - United States, November 2012-July 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID DISEASE; BABESIOSIS C1 [Ray, Gregory; Schulz, Thadeus; Daniels, Wayne] Cryolife Inc, Kennesaw, GA USA. [Brown, Catherine M.] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA. [Backenson, P. Bryon; White, Jennifer L.; Kurpiel, Philip M.] New York State Dept Hlth, Albany, NY 12237 USA. [Linden, Jeanne V.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12237 USA. [Prial, Margaret] Off Med Examiner, Orange Cty, NY USA. [House, Jennifer; Pontones, Pam] Indiana State Dept Hlth, Indianapolis, IN 46202 USA. [Forrester, Joseph D.] CDC, Atlanta, GA 30333 USA. RP Forrester, JD (reprint author), CDC, Atlanta, GA 30333 USA. EM jforrester@cdc.gov NR 10 TC 24 Z9 24 U1 1 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 993 EP 996 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300001 ER PT J AU Bresee, J Reed, C Kim, IK Finelli, L Fry, A Chaves, SS Burns, E Gargiullo, P Jernigan, D Cox, N Singleton, J Zhai, YS O'Halloran, A Kahn, K Lu, PJ Santibanez, TA AF Bresee, Joseph Reed, Carrie Kim, Inkyu Kevin Finelli, Lyn Fry, Alicia Chaves, Sandra S. Burns, Erin Gargiullo, Paul Jernigan, Daniel Cox, Nancy Singleton, James Zhai, Yusheng O'Halloran, Alissa Kahn, Katherine Lu, Peng-Jun Santibanez, Tammy A. TI Estimated Influenza Illnesses and Hospitalizations Averted by Influenza Vaccination - United States, 2012-13 Influenza Season SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Bresee, Joseph; Reed, Carrie; Kim, Inkyu Kevin; Finelli, Lyn; Fry, Alicia; Chaves, Sandra S.; Burns, Erin; Gargiullo, Paul; Jernigan, Daniel; Cox, Nancy] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Singleton, James; Zhai, Yusheng; O'Halloran, Alissa; Kahn, Katherine; Lu, Peng-Jun; Santibanez, Tammy A.] CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Bresee, J (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM jbresee@cdc.gov NR 9 TC 33 Z9 33 U1 1 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 997 EP 1000 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300002 ER PT J AU Ahluwalia, IB Ding, HL Harrison, L Austin, T D'Angelo, D Hastings, P Ruffo, N O'Neil, ME Singleton, JA Bridges, CB AF Ahluwalia, Indu B. Ding, Helen Harrison, Leslie Austin, Toyia D'Angelo, Denise Hastings, Phil Ruffo, Nan O'Neil, Mary Elizabeth Singleton, James A. Bridges, Carolyn B. TI Seasonal Influenza Vaccination Coverage Among Women Who Delivered a Live-Born Infant-21 States and New York City, 2009-10 and 2010-11 Influenza Seasons SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PREGNANT-WOMEN; UNITED-STATES C1 [Ahluwalia, Indu B.; Ding, Helen; Harrison, Leslie; Austin, Toyia; D'Angelo, Denise; Hastings, Phil; Ruffo, Nan; O'Neil, Mary Elizabeth] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Singleton, James A.; Bridges, Carolyn B.] CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Ahluwalia, IB (reprint author), CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM iaa2@cdc.gov NR 10 TC 4 Z9 4 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 1001 EP 1004 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300003 ER PT J AU Cardemil, C Ng, T Pabst, L AF Cardemil, Cristina Ng, Terence Pabst, Laura TI Progress in Immunization Information Systems - United States, 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Cardemil, Cristina; Ng, Terence; Pabst, Laura] CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Cardemil, C (reprint author), CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM ccardemil@cdc.gov NR 10 TC 16 Z9 16 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 1005 EP 1008 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300004 ER PT J AU Etsano, A Shuaib, F Mkanda, P Banda, R Korir, C Corkum, M Ndiaye, S Ashenafi, S Mahoney, F Vertefeuille, JF Burns, CC AF Etsano, Andrew Shuaib, Faisal Mkanda, Pascal Banda, Richard Korir, Charles Corkum, Melissa Ndiaye, Serigne Ashenafi, Samrawit Mahoney, Frank Vertefeuille, John F. Burns, Cara C. TI Progress Toward Poliomyelitis Eradication - Nigeria, January 2012-September 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Ndiaye, Serigne; Ashenafi, Samrawit; Mahoney, Frank; Vertefeuille, John F.] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Burns, Cara C.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Ndiaye, S (reprint author), CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. EM sndiaye@cdc.gov NR 8 TC 15 Z9 15 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 1009 EP 1013 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300005 ER PT J AU Turner, RE Heetderks, AJ Khan, AD Chorba, TL Jereb, JA AF Turner, Rebekah E. Heetderks, Andrew J. Khan, Awal D. Chorba, Terence L. Jereb, John A. TI Extent and Effects of Recurrent Shortages of Purified-Protein Derivative Tuberculin Skin Test Antigen Solutions - United States, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Turner, Rebekah E.; Heetderks, Andrew J.; Khan, Awal D.; Chorba, Terence L.; Jereb, John A.] CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Jereb, JA (reprint author), CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM jjereb@cdc.gov NR 5 TC 4 Z9 4 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 1014 EP 1015 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300006 ER PT J AU Ghosh, T Herlihy, R Van Dyke, M Kuhn, S Sherry, B Halliday, M Spelke, B Bayleyegn, T Wolkin, A Lewis, LS Fechter-Leggett, E Olayinka, O AF Ghosh, Tista Herlihy, Rachel Van Dyke, Mike Kuhn, Stephanie Sherry, Burrer Halliday, Melissa Spelke, Bridget Bayleyegn, Tesfaye Wolkin, Amy Lewis, Lauren S. Fechter-Leggett, Ethan Olayinka, Olaniyi TI Severe Illness Associated with Reported Use of Synthetic Marijuana - Colorado, August-September 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Olayinka, Olaniyi] CDC, Atlanta, GA 30333 USA. RP Olayinka, O (reprint author), CDC, Atlanta, GA 30333 USA. EM oolayinka@cdc.gov OI Spelke, Bridget/0000-0002-5950-8197 NR 4 TC 15 Z9 16 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 13 PY 2013 VL 62 IS 49 BP 1016 EP 1017 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WZ UT WOS:000328568300007 ER PT J AU Brady, OJ Johansson, MA Guerra, CA Bhatt, S Golding, N Pigott, DM Delatte, H Grech, MG Leisnham, PT Maciel-de-Freitas, R Styer, LM Smith, DL Scott, TW Gething, PW Hay, SI AF Brady, Oliver J. Johansson, Michael A. Guerra, Carlos A. Bhatt, Samir Golding, Nick Pigott, David M. Delatte, Helene Grech, Marta G. Leisnham, Paul T. Maciel-de-Freitas, Rafael Styer, Linda M. Smith, David L. Scott, Thomas W. Gething, Peter W. Hay, Simon I. TI Modelling adult Aedes aegypti and Aedes albopictus survival at different temperatures in laboratory and field settings SO PARASITES & VECTORS LA English DT Article DE Aedes; Survival; Temperature; Mortality; Longevity; Modelling; Mark-release-recapture; Dengue; Transmission; Generalised additive models ID DENGUE VIRUS TRANSMISSION; BLOOD PLUS SUGAR; RIO-DE-JANEIRO; DIPTERA-CULICIDAE; RELEASE-RECAPTURE; PUERTO-RICO; CONTAINER PRODUCTIVITY; LIFE TABLE; MORTALITY; MOSQUITOS AB Background: The survival of adult female Aedes mosquitoes is a critical component of their ability to transmit pathogens such as dengue viruses. One of the principal determinants of Aedes survival is temperature, which has been associated with seasonal changes in Aedes populations and limits their geographical distribution. The effects of temperature and other sources of mortality have been studied in the field, often via mark-release-recapture experiments, and under controlled conditions in the laboratory. Survival results differ and reconciling predictions between the two settings has been hindered by variable measurements from different experimental protocols, lack of precision in measuring survival of free-ranging mosquitoes, and uncertainty about the role of age-dependent mortality in the field. Methods: Here we apply generalised additive models to data from 351 published adult Ae. aegypti and Ae. albopictus survival experiments in the laboratory to create survival models for each species across their range of viable temperatures. These models are then adjusted to estimate survival at different temperatures in the field using data from 59 Ae. aegypti and Ae. albopictus field survivorship experiments. The uncertainty at each stage of the modelling process is propagated through to provide confidence intervals around our predictions. Results: Our results indicate that adult Ae. albopictus has higher survival than Ae. aegypti in the laboratory and field, however, Ae. aegypti can tolerate a wider range of temperatures. A full breakdown of survival by age and temperature is given for both species. The differences between laboratory and field models also give insight into the relative contributions to mortality from temperature, other environmental factors, and senescence and over what ranges these factors can be important. Conclusions: Our results support the importance of producing site-specific mosquito survival estimates. By including fluctuating temperature regimes, our models provide insight into seasonal patterns of Ae. aegypti and Ae. albopictus population dynamics that may be relevant to seasonal changes in dengue virus transmission. Our models can be integrated with Aedes and dengue modelling efforts to guide and evaluate vector control, better map the distribution of disease and produce early warning systems for dengue epidemics. C1 [Brady, Oliver J.; Guerra, Carlos A.; Bhatt, Samir; Golding, Nick; Pigott, David M.; Gething, Peter W.; Hay, Simon I.] Univ Oxford, Dept Zool, Spatial Ecol & Epidemiol Grp, Tinbergen Bldg,South Parks Rd, Oxford, England. [Johansson, Michael A.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR USA. [Delatte, Helene] CIRAD, UMR PVBMT, St Piarre 97410, Reunion. [Grech, Marta G.] Univ Nacl Patagonia San Juan Bosco, FCN Sede, Lab Invest Ecol & Sistemat Anim, Esquel, Chubut, Argentina. [Leisnham, Paul T.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. [Maciel-de-Freitas, Rafael] Fiocruz MS, Inst Oswaldo Cruz, Lab Transmissores Hematozoarios, BR-21045900 Rio De Janeiro, RJ, Brazil. [Styer, Linda M.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA. [Smith, David L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Smith, David L.; Scott, Thomas W.; Hay, Simon I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Brady, OJ (reprint author), Univ Oxford, Dept Zool, Spatial Ecol & Epidemiol Grp, Tinbergen Bldg,South Parks Rd, Oxford, England. EM oliver.brady@zoo.ox.ac.uk RI Hay, Simon/F-8967-2015; OI Hay, Simon/0000-0002-0611-7272; Pigott, David/0000-0002-6731-4034; Golding, Nick/0000-0001-8916-5570; Gething, Peter/0000-0001-6759-5449; Brady, Oliver/0000-0002-3235-2129 FU BBSRC studentship; Department of Zoology at the University of Oxford; Medical Research Council (UK) Career Development Fellow [K00669X]; Bill and Melinda Gates Foundation [OPP1068048]; Bill AMP; Melinda Gates Foundation [OPP1053338]; Wellcome Trust [095066]; EU [21803]; RAPIDD program of the Science AMP; Technology Directorate; Department of Homeland Security; Fogarty International Center, National Institutes of Health FX O.J.B. is funded by a BBSRC studentship. DMP is funded by a Sir Richard Southwood Graduate Scholarship from the Department of Zoology at the University of Oxford. P.W.G is a Medical Research Council (UK) Career Development Fellow (#K00669X) and receives support from the Bill and Melinda Gates Foundation (#OPP1068048) which also supports S.B. N.G. is funded by a grant from the Bill & Melinda Gates Foundation (OPP1053338). S. I. H. is funded by a Senior Research Fellowship from the Wellcome Trust (095066). This study was partially funded by EU grant 21803 IDAMS (http://www.idams.eu). The contents of this publication are the sole responsibility of the authors and don't necessarily reflect the views of the European Commission. S.I.H. C.A.G. and T.W.S. also acknowledge funding support from the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health. NR 79 TC 56 Z9 56 U1 5 U2 58 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 12 PY 2013 VL 6 AR 351 DI 10.1186/1756-3305-6-351 PG 12 WC Parasitology SC Parasitology GA 277RW UT WOS:000328838000002 PM 24330720 ER PT J AU Wiringa, AE Shutt, KA Marsh, JW Cohn, AC Messonnier, NE Zansky, SM Petit, S Farley, MM Gershman, K Lynfield, R Reingold, A Schaffner, W Thompson, J Brown, ST Lee, BY Harrison, LH AF Wiringa, Ann E. Shutt, Kathleen A. Marsh, Jane W. Cohn, Amanda C. Messonnier, Nancy E. Zansky, Shelley M. Petit, Susan Farley, Monica M. Gershman, Ken Lynfield, Ruth Reingold, Arthur Schaffner, William Thompson, Jamie Brown, Shawn T. Lee, Bruce Y. Harrison, Lee H. TI Geotemporal Analysis of Neisseria meningitidis Clones in the United States: 2000-2005 SO PLOS ONE LA English DT Article ID INVASIVE MENINGOCOCCAL DISEASE; OUTBREAK DETECTION; SURVEILLANCE; INFECTION; RISK AB Background: The detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in the United States are believed to be sporadic. Methods: Meningococcal isolates from 9 Active Bacterial Core surveillance sites throughout the United States from 2000 through 2005 were classified according to serogroup, multilocus sequence typing, and outer membrane protein (porA, porB, and fetA) genotyping. Clones were defined as isolates that were indistinguishable according to this characterization. Case data were aggregated to the census tract level and all non-singleton clones were assessed for non-random spatial and temporal clustering using retrospective space-time analyses with a discrete Poisson probability model. Results: Among 1,062 geocoded cases with available isolates, 438 unique clones were identified, 78 of which had >= 2 isolates. 702 cases were attributable to non-singleton clones, accounting for 66.0% of all geocoded cases. 32 statistically significant clusters comprised of 107 cases (10.1% of all geocoded cases) were identified. Clusters had the following attributes: included 2 to 11 cases; 1 day to 33 months duration; radius of 0 to 61.7 km; and attack rate of 0.7 to 57.8 cases per 100,000 population. Serogroups represented among the clusters were: B (n = 12 clusters, 45 cases), C (n = 11 clusters, 27 cases), and Y (n = 9 clusters, 35 cases); 20 clusters (62.5%) were caused by serogroups represented in meningococcal vaccines that are commercially available in the United States. Conclusions: Around 10% of meningococcal disease cases in the U.S. could be assigned to a geotemporal cluster. Molecular characterization of isolates, combined with geotemporal analysis, is a useful tool for understanding the spread of virulent meningococcal clones and patterns of transmission in populations. C1 [Wiringa, Ann E.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Shutt, Kathleen A.; Marsh, Jane W.; Harrison, Lee H.] Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Pittsburgh, PA 15260 USA. [Shutt, Kathleen A.; Marsh, Jane W.; Harrison, Lee H.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Cohn, Amanda C.; Messonnier, Nancy E.] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Atlanta, GA USA. [Zansky, Shelley M.] New York State Dept Hlth, Albany, NY USA. [Petit, Susan] Connecticut Dept Publ Hlth, Hartford, CT USA. [Farley, Monica M.] Emory Univ, Atlanta, GA 30322 USA. [Farley, Monica M.] VA Med Ctr, Atlanta, GA USA. [Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Reingold, Arthur] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Thompson, Jamie] Oregon Publ Hlth Div, Portland, OR USA. [Brown, Shawn T.] Carnegie Mellon Univ, Pittsburgh Supercomp Ctr, Pittsburgh, PA 15213 USA. [Lee, Bruce Y.] Univ Pittsburgh, Sch Med, Publ Hlth Computat & Operat Res PHICOR, Pittsburgh, PA USA. [Lee, Bruce Y.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. RP Harrison, LH (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Pittsburgh, PA 15260 USA. EM lharriso@edc.pitt.edu OI Shutt, Kathleen/0000-0003-3376-6152 FU US Centers for Disease Control and Prevention [DHM 99-006042] FX This study was supported by the US Centers for Disease Control and Prevention grant DHM 99-006042. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. CDC coauthors participated in various aspects of the study and manuscript reparation. NR 32 TC 5 Z9 5 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 12 PY 2013 VL 8 IS 12 AR e82048 DI 10.1371/journal.pone.0082048 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 276EU UT WOS:000328731800035 PM 24349182 ER PT J AU Aminov, Z Haase, RF Pavuk, M Carpenter, DO AF Aminov, Zafar Haase, Richard F. Pavuk, Marian Carpenter, David O. CA Anniston Environm Hlth Res Consort TI Analysis of the effects of exposure to polychlorinated biphenyls and chlorinated pesticides on serum lipid levels in residents of Anniston, Alabama SO ENVIRONMENTAL HEALTH LA English DT Article DE Cholesterol; Triglycerides; Persistent organic pollutants; LDL cholesterol; HDL cholesterol; Hexachlorobenzene; DDT; PCBs ID PERSISTENT ORGANIC POLLUTANTS; HEPATIC GENE-EXPRESSION; CARDIOVASCULAR-DISEASE; RAT-LIVER; LIPOPROTEIN CHOLESTEROL; PCBS; METABOLISM; PROTEIN; HEALTH; ADJUSTMENT AB Background: Anniston, Alabama, is the site of a former Monsanto plant where polychlorinated biphenyls (PCBs) were manufactured from 1929 until 1971. Residents of Anniston are known to have elevated levels of PCBs. The objective of the study was to test the hypothesis that levels of the various lipid components (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) are differentially associated with concentrations of total PCBs and total pesticides, and further that different congeners, congener groups and different pesticides do not have identical associations in serum samples obtained from Anniston residents in a cross-sectional study. Methods: Fasting serum samples were obtained from 575 residents of Anniston who were not on any lipid-lowering medication and were analyzed for 35 PCB congeners, nine chlorinated pesticides, total cholesterol, LDL and HDL cholesterol and triglyceride concentrations. Associations between toxicant concentrations and lipid levels were determined using multiple linear regression analysis. Results: We observed that elevated serum concentrations of lipids were associated with elevated serum concentrations of SPCBs and summed pesticides in analyses adjusted for age, race, gender, BMI, alcohol consumption, smoking and exercising status. The strongest associations were seen for PCB congeners with three, four, or at least eight substituted chlorines. Mono-ortho substituted congeners 74 and 156, di-ortho congeners 172 and 194, and tri- and tetra-ortho congeners 199, 196-203, 206 and 209 each were significantly associated with total lipids, total cholesterol and triglycerides. Serum concentrations of HCB and chlordane also had strong associations with lipid components. Conclusions: Increased concentrations of PCBs and organochlorine pesticides are associated with elevations in total serum lipids, total cholesterol and triglycerides, but the patterns are different for different groups of PCBs and different pesticides. These observations show selective effects of different organochlorines on serum concentrations of different groups of lipids. This elevation in concentrations of serum lipids may be the basis for the increased incidence of cardiovascular disease found in persons with elevated exposures to PCBs and chlorinated pesticides. C1 [Aminov, Zafar; Haase, Richard F.; Carpenter, David O.] Univ Albany, Inst Hlth & Environm, Rensselaer, NY 12144 USA. [Pavuk, Marian] Agcy Tox Subst & Dis Registry, Atlanta, GA USA. RP Carpenter, DO (reprint author), Univ Albany, Inst Hlth & Environm, 5 Univ Pl, Rensselaer, NY 12144 USA. EM dcarpenter@albany.edu FU Agency for Toxic Substances and Disease Registry [5U50TS473215]; Passport Foundation FX The data collection was supported by a grant from the Agency for Toxic Substances and Disease Registry to Jacksonville State University, # 5U50TS473215. We thank Wayman Turner and Andreas Sjodin at the National Center for Environmental Health's Division of Laboratory Sciences, Center for Disease Control and Prevention, Atlanta, GA, for their expert analytical work on this study. The Anniston Environmental Health Research Consortium Steering Committee members include Shirley Baker, community representative; Scott Bartell, UC Irvine; James Olson, University at Buffalo; Russell Foushee, Alan Percy, University of Alabama at Birmingham; David O. Carpenter, University at Albany; Jane Cash; Martha Lavender, Christie Shelton, Jacksonville State University; Howard Frumkin, University of Washington; Marian Pavuk ATSCR/CDC; Paula Rosenbaum, Allen Silverstone, Ruth Weinstock, Upstate Medical University; and Kirsten Moysich, Roswell Park Cancer Institute. ZA was supported by a grant from the Passport Foundation to the Institute for Health and the Environment of the University at Albany. The contents of this publication are solely the responsibility of the authors and do not necessarily represent ATSDR's official views. NR 50 TC 13 Z9 16 U1 0 U2 20 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD DEC 11 PY 2013 VL 12 AR 108 DI 10.1186/1476-069X-12-108 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 297VZ UT WOS:000330284500001 PM 24325314 ER PT J AU Kawwass, JF Monsour, M Crawford, S Kissin, DM Session, DR Kulkarni, AD Jamieson, DJ AF Kawwass, Jennifer F. Monsour, Michael Crawford, Sara Kissin, Dmitry M. Session, Donna R. Kulkarni, Aniket D. Jamieson, Denise J. CA Natl ART Surveillance Syst NASS Gr TI Trends and Outcomes for Donor Oocyte Cycles in the United States, 2000-2010 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ASSISTED REPRODUCTIVE TECHNOLOGY; SINGLE-EMBRYO-TRANSFER; PERINATAL OUTCOMES; MATERNAL AGE; PREGNANCY; WOMEN; DONATION; RISKS AB IMPORTANCE The prevalence of oocyte donation for in vitro fertilization (IVF) has increased in the United States, but little information is available regarding maternal or infant outcomes to improve counseling and clinical decision making. OBJECTIVES To quantify trends in donor oocyte cycles in the United States and to determine predictors of a good perinatal outcome among IVF cycles using fresh (noncryopreserved) embryos derived from donor oocytes. DESIGN, SETTING, AND PARTICIPANTS Analysis of data from the Centers for Disease Control and Prevention's National ART Surveillance System, to which fertility centers are mandated to report and which includes data on more than 95% of all IVF cycles performed in the United States. Data from 2000 to 2010 described trends. Data from 2010 determined predictors. MAIN OUTCOMES AND MEASURES Good perinatal outcome, defined as a singleton live-born infant delivered at 37 weeks or later and weighing 2500 g or more. RESULTS From 2000 to 2010, data from 443 clinics (93% of all US fertility centers) were included. The annual number of donor oocyte cycles significantly increased, from 10 801 to 18 306. Among all donor oocyte cycles, an increasing trend was observed from 2000 to 2010 in the proportion of cycles using frozen (vs fresh) embryos (26.7%[95% CI, 25.8%-27.5%] to 40.3%[95% CI, 39.6%-41.1%]) and elective single-embryo transfers (vs transfer of multiple embryos) (0.8%[95% CI, 0.7%-1.0%] to 14.5%[95% CI, 14.0%-15.1%]). Good perinatal outcomes increased from 18.5%(95% CI, 17.7%-19.3%) to 24.4%(95% CI, 23.8%-25.1%) (P < .001 for all listed trends). Mean donor and recipient ages remained stable at 28 (SD, 2.8) years and 41 (SD, 5.3) years, respectively. In 2010, 396 clinics contributed data. For donor oocyte cycles using fresh embryos (n = 9865), 27.5%(95% CI, 26.6%-28.4%) resulted in good perinatal outcome. Transfer of an embryo at day 5 (adjusted odds ratio [OR], 1.17 [95% CI, 1.04-1.32]) and elective single-embryo transfers (adjusted OR, 2.32 [95% CI, 1.92-2.80]) were positively associated with good perinatal outcome; tubal (adjusted OR, 0.72 [95% CI, 0.60-0.86]) or uterine (adjusted OR, 0.74 [95% CI, 0.58-0.94]) factor infertility and non-Hispanic black recipient race/ethnicity (adjusted OR, 0.48 [95% CI, 0.35-0.67]) were associated with decreased odds of good outcome. Recipient age was not associated with likelihood of good perinatal outcome. CONCLUSIONS AND RELEVANCE In the United States from 2000 to 2010, there was an increase in number of donor oocyte cycles, accompanied by an increase in good outcomes. Further studies are needed to understand the mechanisms underlying the factors associated with less successful outcomes. C1 [Kawwass, Jennifer F.; Kissin, Dmitry M.; Session, Donna R.; Jamieson, Denise J.] Emory Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Atlanta, GA 30308 USA. [Kawwass, Jennifer F.; Monsour, Michael; Crawford, Sara; Kissin, Dmitry M.; Kulkarni, Aniket D.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Kawwass, JF (reprint author), Emory Univ, Sch Med, Dept Gynecol & Obstet, 550 Peachtree St,Ste 1800, Atlanta, GA 30308 USA. EM jennifer.kawwass@emory.edu FU Intramural CDC HHS [CC999999] NR 23 TC 29 Z9 29 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 11 PY 2013 VL 310 IS 22 BP 2426 EP 2434 DI 10.1001/jama.2013.280924 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 266NN UT WOS:000328030900023 PM 24135860 ER PT J AU Zhang, XY Morrison-Carpenter, T Holt, JB Callahan, DB AF Zhang, Xingyou Morrison-Carpenter, Teresa Holt, James B. Callahan, David B. TI Trends in adult current asthma prevalence and contributing risk factors in the United States by state: 2000-2009 SO BMC PUBLIC HEALTH LA English DT Article DE Current asthma; Smoking; Obesity; Trend; The United States ID OUTDOOR AIR-POLLUTION; BODY-MASS INDEX; SELF-REPORTED ASTHMA; ONSET ASTHMA; RESPIRATORY SYMPTOMS; BRONCHIAL HYPERRESPONSIVENESS; PROSPECTIVE COHORT; CHILDHOOD ASTHMA; INCIDENT ASTHMA; SMOKE EXPOSURE AB Background: Current asthma prevalence among adults in the United States has reached historically high levels. Although national-level estimates indicate that asthma prevalence among adults increased by 33% from 2000 to 2009, state-specific temporal trends of current asthma prevalence and their contributing risk factors have not been explored. Methods: We used 2000-2009 Behavioral Risk Factor Surveillance System data from all 50 states and the District of Columbia (D.C.) to estimate state-specific current asthma prevalence by 2-year periods (2000-2001, 2002-2003, 2004-2005, 2006-2007, 2008-2009). We fitted a series of four logistic-regression models for each state to evaluate whether there was a statistically significant linear change in the current asthma prevalence over time, accounting for sociodemographic factors, smoking status, and weight status (using body mass index as the indicator). Results: During 2000-2009, current asthma prevalence increased in all 50 states and D.C., with significant increases in 46/50 (92%) states and D.C. After accounting for weight status in the model series with sociodemographic factors, and smoking status, 10 states (AR, AZ, IA, IL, KS, ME, MT, UT, WV, and WY) that had previously shown a significant increase did not show a significant increase in current asthma prevalence. Conclusions: There was a significant increasing trend in state-specific current asthma prevalence among adults from 2000 to 2009 in most states in the United States. Obesity prevalence appears to contribute to increased current asthma prevalence in some states. C1 [Zhang, Xingyou; Holt, James B.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Morrison-Carpenter, Teresa; Callahan, David B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. RP Zhang, XY (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, 4770 Buford Highway,Mailstop F78, Atlanta, GA 30341 USA. EM gyx8@cdc.gov NR 67 TC 14 Z9 14 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 10 PY 2013 VL 13 AR 1156 DI 10.1186/1471-2458-13-1156 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 284IC UT WOS:000329308500004 PM 24325173 ER PT J AU Masanja, IM Selemani, M Khatib, RA Amuri, B Kuepfer, I Kajungu, D de Savigny, D Kachur, SP Skarbinski, J AF Masanja, Irene M. Selemani, Majige Khatib, Rashid A. Amuri, Baraka Kuepfer, Irene Kajungu, Dan de Savigny, Don Kachur, S. Patrick Skarbinski, Jacek TI Correct dosing of artemether-lumefantrine for management of uncomplicated malaria in rural Tanzania: do facility and patient characteristics matter? SO MALARIA JOURNAL LA English DT Article DE Artemether lumefantrine dosing; Uncomplicated malaria; Tanzania ID RAPID DIAGNOSTIC-TESTS; TREATMENT POLICY; HEALTH FACILITIES; QUALITY AB Background: Use of artemisinin-based combination therapy (ACT), such as artemether-lumefantrine (AL), requires a strict dosing schedule that follows the drugs' pharmacokinetic properties. The quality of malaria case management was assessed in two areas in rural Tanzania, to ascertain patient characteristics and facility-specific factors that influence correct dosing of AL for management of uncomplicated malaria. Methods: Exit interviews were conducted with patients attending health facilities for initial illness consultation. Information about health workers' training and supervision visits was collected. Health facilities were inventoried for capacity and availability of medical products related to care of malaria patients. The outcome was correct dosing of AL based on age and weight. Logistic regression was used to assess health facility factors and patient characteristics associated with correct dosing of AL by age and weight. Results: A total of 1,531 patients were interviewed, but 60 pregnant women were excluded from the analysis. Only 503 (34.2%) patients who received AL were assessed for correct dosing. Most patients who received AL (85.3%) were seen in public health facilities, 75.7% in a dispensary and 91.1% in a facility that had AL in stock on the survey day. Overall, 92.1% (463) of AL prescriptions were correct by age or weight; but 85.7% of patients received correct dosing by weight alone and 78.5% received correct dosing by age alone. In multivariate analysis, patients in the middle dosing bands in terms of age or weight, had statistically significant lower odds of correct AL dosing (p < 0.05) compared to those in the lowest age or weight group. Other factors such as health worker supervision and training on ACT did not improve the odds of correct AL dosing. Conclusion: Although malaria treatment guidelines indicate AL dosing can be prescribed based on age or weight of the patient, findings from this study show that patients within the middle age and weight dosing bands were least likely to receive a correct dose by either measure. Clinicians should be made aware of AL dosing errors for patients aged three to 12 years and advised to use weight-based prescriptions whenever possible. C1 [Masanja, Irene M.; Selemani, Majige; Khatib, Rashid A.; Amuri, Baraka] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [Masanja, Irene M.; Kuepfer, Irene; de Savigny, Don] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland. [Masanja, Irene M.; de Savigny, Don] Univ Basel, CH-4003 Basel, Switzerland. [Masanja, Irene M.; Selemani, Majige; Khatib, Rashid A.; Amuri, Baraka; Kuepfer, Irene; Kajungu, Dan; de Savigny, Don; Kachur, S. Patrick; Skarbinski, Jacek] INDEPTH Network Effectiveness & Safety Studies A, Dar Es Salaam, Tanzania. [Kachur, S. Patrick; Skarbinski, Jacek] US Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, Atlanta, GA USA. RP Masanja, IM (reprint author), Ifakara Hlth Inst, POB 78373, Dar Es Salaam, Tanzania. EM imasanja@ihi.or.tz RI AMURI, Mbaraka/C-5386-2011 OI AMURI, Mbaraka/0000-0002-8583-9555 FU Ifakara Health Institute administration department; Ifakara Health Institute procurement department; Ifakara Health Institute finance department FX The authors are grateful to all health providers and patients who participated in the surveys. Sincere appreciation also goes to all field workers who spent long hours in the field for interview and chasing blood smears results to return them to respective facilities before moving on to the next one. In addition, we thank the study microscopist Mr. Bakari Kissa and field supervisor Mr. Ismail Mninge for their commendable commitment to implement quality study protocols. Lastly, we are grateful to the Ifakara Health Institute administration, procurement and finance departments for the support they provided throughout the study period. NR 14 TC 4 Z9 4 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 10 PY 2013 VL 12 AR 446 DI 10.1186/1475-2875-12-446 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 281OJ UT WOS:000329110600002 PM 24325267 ER PT J AU Halsey, NA Griffioen, M Dreskin, SC Dekker, CL Wood, R Sharma, D Jones, JF LaRussa, PS Garner, J Berger, M Proveaux, T Vellozzi, C Broder, K Setse, R Pahud, B Hrncir, D Choi, H Sparks, R Williams, SE Engler, RJ Gidudu, J Baxter, R Klein, N Edwards, K Cano, M Kelso, JM AF Halsey, Neal A. Griffioen, Mari Dreskin, Stephen C. Dekker, Cornelia L. Wood, Robert Sharma, Devindra Jones, James F. LaRussa, Philip S. Garner, Jenny Berger, Melvin Proveaux, Tina Vellozzi, Claudia Broder, Karen Setse, Rosanna Pahud, Barbara Hrncir, David Choi, Howard Sparks, Robert Williams, Sarah Elizabeth Engler, Renata J. Gidudu, Jane Baxter, Roger Klein, Nicola Edwards, Kathryn Cano, Maria Kelso, John M. CA Hypersensitivity Working Grp Clin TI Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: Reports to VAERS SO VACCINE LA English DT Article DE Immunization; Influenza vaccine; Hypersensitivity; Anaphylaxis; Urticaria; Allergic reactions; H1N1 influenza vaccine ID DUCK RUBELLA VACCINE; ADVERSE EVENTS; ANAPHYLAXIS; SAFETY; AGE; EMERGENCY; PROJECT; NETWORK AB Background: Hypersensitivity disorders following vaccinations are a cause for concern. Objective: To determine the type and rate by age, gender, and vaccine received for reported hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines. Design: A systematic review of reports to the Vaccine Adverse Event Reporting System (VAERS) following monovalent 2009 pandemic influenza A (H1N1) vaccines. Setting/patients: US Civilian reports following vaccine received from October 1, 2009 through May 31, 2010. Measurements: Age, gender, vaccines received, diagnoses, clinical signs, and treatment were reviewed by nurses and physicians with expertise in vaccine adverse events. A panel of experts, including seven allergists reviewed complex illnesses and those with conflicting evidence for classification of the event. Results: Of 1984 reports, 1286 were consistent with immediate hypersensitivity disorders and 698 were attributed to anxiety reactions, syncope, or other illnesses. The female-to-male ratio was >4:1 for persons 20-to-59 years of age, but approximately equal for children under 10. One hundred eleven reports met Brighton Collaboration criteria for anaphylaxis; only one-half received epinephrine for initial therapy. The overall rate of reported hypersensitivity reactions was 10.7 per million vaccine doses distributed, with a 2-fold higher rate for live vaccine. Limitations: Underreporting, especially of mild events, would result in an underestimate of the true rate of immediate hypersensitivity reactions. Selective reporting of events in adult females could have resulted in higher rates than reported for males. Conclusions: Adult females may be at higher risk of hypersensitivity reactions after influenza vaccination than men. Although the risk of hypersensitivity reactions following 2009 pandemic influenza A (H1N1) vaccines was low, all clinics administering vaccines should be familiar with treatment guidelines for these adverse events, including the use of intramuscular epinephrine early in the course of serious hypersensitivity reactions. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Halsey, Neal A.; Griffioen, Mari; Garner, Jenny; Proveaux, Tina; Setse, Rosanna; Choi, Howard] Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, Baltimore, MD 21205 USA. [Dreskin, Stephen C.] Univ Colorado, Dept Med, Denver, CO USA. [Dekker, Cornelia L.] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA. [Wood, Robert] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Allergy & Immunol, Baltimore, MD 21205 USA. [Sharma, Devindra; Vellozzi, Claudia; Broder, Karen; Gidudu, Jane; Cano, Maria] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. [Jones, James F.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Atlanta, GA USA. [LaRussa, Philip S.] Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA. [Berger, Melvin] CSL Behring, King Of Prussia, PA USA. [Pahud, Barbara] Univ Missouri, Childrens Mercy Hosp & Clin, Kansas City, MO 64110 USA. [Hrncir, David; Engler, Renata J.] Walter Reed Natl Mil Med Ctr, US Army Publ Hlth Command, Mil Vaccine Agcy, Vaccine Healthcare Ctr Network, Bethesda, MD USA. [Sparks, Robert; Williams, Sarah Elizabeth; Edwards, Kathryn] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Baxter, Roger; Klein, Nicola] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Kelso, John M.] Scripps Clin, Div Allergy Asthma & Immunol, San Diego, CA USA. RP Halsey, NA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, 615 N Wolfe St,Room W5041, Baltimore, MD 21205 USA. EM nhalsey@jhsph.edu RI Garner, Joseph/C-8422-2009 FU Clinical Immunization Safety Assessment Network; Centers for Disease Control and Prevention (CDC) [200-2002-00732] FX We thank Elaine Miller and Oidda Museru for their assistance in obtaining reports from the Vaccine Adverse Event Reporting System. This study was supported by the Clinical Immunization Safety Assessment Network and Vaccine Safety Datalink through a subcontract with America's Health Insurance Plans under contract 200-2002-00732 from the Centers for Disease Control and Prevention (CDC). NR 32 TC 9 Z9 9 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 9 PY 2013 VL 31 IS 51 BP 6107 EP 6112 DI 10.1016/j.vaccine.2013.09.066 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 280EB UT WOS:000329010400012 PM 24120547 ER PT J AU Schulte, PA Geraci, CL Murashov, V Kuempel, ED Zumwalde, RD Castranova, V Hoover, MD Hodson, L Martinez, KF AF Schulte, P. A. Geraci, C. L. Murashov, V. Kuempel, E. D. Zumwalde, R. D. Castranova, V. Hoover, M. D. Hodson, L. Martinez, K. F. TI Occupational safety and health criteria for responsible development of nanotechnology SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Editorial Material DE Risk assessment; Ethics; Risk management; Regulation; Toxicology; Environmental and health effects ID EXPOSURE CONTROL LIMITS; RISK-MANAGEMENT; ENGINEERED NANOMATERIALS; PULMONARY RESPONSES; CARBON NANOTUBE; AIR-POLLUTION; MEASUREMENT STRATEGIES; EPIDEMIOLOGIC-RESEARCH; MEDICAL-SURVEILLANCE; INHALATION EXPOSURE AB Organizations around the world have called for the responsible development of nanotechnology. The goals of this approach are to emphasize the importance of considering and controlling the potential adverse impacts of nanotechnology in order to develop its capabilities and benefits. A primary area of concern is the potential adverse impact on workers, since they are the first people in society who are exposed to the potential hazards of nanotechnology. Occupational safety and health criteria for defining what constitutes responsible development of nanotechnology are needed. This article presents five criterion actions that should be practiced by decision-makers at the business and societal levels-if nanotechnology is to be developed responsibly. These include (1) anticipate, identify, and track potentially hazardous nanomaterials in the workplace; (2) assess workers' exposures to nanomaterials; (3) assess and communicate hazards and risks to workers; (4) manage occupational safety and health risks; and (5) foster the safe development of nanotechnology and realization of its societal and commercial benefits. All these criteria are necessary for responsible development to occur. Since it is early in the commercialization of nanotechnology, there are still many unknowns and concerns about nanomaterials. Therefore, it is prudent to treat them as potentially hazardous until sufficient toxicology, and exposure data are gathered for nanomaterial-specific hazard and risk assessments. In this emergent period, it is necessary to be clear about the extent of uncertainty and the need for prudent actions. C1 [Schulte, P. A.; Geraci, C. L.; Murashov, V.; Kuempel, E. D.; Zumwalde, R. D.; Castranova, V.; Hoover, M. D.; Hodson, L.; Martinez, K. F.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Martinez, K. F.] Hassett Willis & Co, Washington, DC USA. RP Schulte, PA (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS C-14, Cincinnati, OH 45226 USA. EM pschulte@cdc.gov NR 160 TC 17 Z9 17 U1 2 U2 50 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 EI 1572-896X J9 J NANOPART RES JI J. Nanopart. Res. PD DEC 7 PY 2013 VL 16 IS 1 AR UNSP 2153 DI 10.1007/s11051-013-2153-9 PG 17 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 269DU UT WOS:000328222100001 ER PT J AU King, ME Lu, PJ O'Halloran, A Ding, H Lozier, MJ AF King, Michael E. Lu, Peng-jun O'Halloran, Alissa Ding, Helen Lozier, Matthew J. TI Vaccination Coverage Among Persons with Asthma - United States, 2010-2011 Influenza Season SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material ID ADULTS C1 [Lozier, Matthew J.] CDC, EIS, Atlanta, GA 30333 USA. RP Lozier, MJ (reprint author), CDC, EIS, Atlanta, GA 30333 USA. EM mlozier@cdc.gov NR 10 TC 8 Z9 9 U1 0 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 6 PY 2013 VL 62 IS 48 BP 973 EP 978 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WT UT WOS:000328567700001 ER PT J AU Rounds, J Schlegel, J Lane, T Higa, J Kissler, B Culpepper, W Williams, I Hausman, L AF Rounds, Joshua Schlegel, Julie Lane, Tom Higa, Jeffrey Kissler, Bonnie Culpepper, Wright Williams, Ian Hausman, Leslie TI Multistate Outbreak of Salmonella Chester Infections Associated with Frozen Meals-18 States, 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Rounds, Joshua] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Schlegel, Julie] S Carolina Dept Hlth & Environm Control, Columbia, SC 29201 USA. [Kissler, Bonnie] USDA, Food Safety & Inspect Svc, Washington, DC USA. [Culpepper, Wright; Williams, Ian; Hausman, Leslie] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Hausman, L (reprint author), CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM lhausman@cdc.gov NR 9 TC 4 Z9 5 U1 0 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 6 PY 2013 VL 62 IS 48 BP 979 EP 982 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WT UT WOS:000328567700002 ER PT J AU Dabbagh, AJ Dumolard, L Gacic-Dobo, M Grant, GB Reef, SE AF Dabbagh, Alya J. Dumolard, Laure Gacic-Dobo, Marta Grant, Gavin B. Reef, Susan E. TI Rubella and Congenital Rubella Syndrome Control and Elimination - Global Progress, 2000-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Dabbagh, Alya J.; Dumolard, Laure; Gacic-Dobo, Marta] WHO, Dept Immunizat Vaccines & Biol, CH-1211 Geneva, Switzerland. [Grant, Gavin B.; Reef, Susan E.] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Grant, GB (reprint author), CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. EM gbgrant@cdc.gov NR 7 TC 16 Z9 18 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 6 PY 2013 VL 62 IS 48 BP 983 EP 986 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WT UT WOS:000328567700003 ER PT J AU Quest, C Klos, R Davis, JP Canon, AJ AF Quest, Carol Klos, Rachel Davis, Jeffrey P. Canon, Abbey J. TI Escherichia coli O157: H7 Outbreak Associated with Seasonal Consumption of Raw Ground Beef - Wisconsin, December 2012-January 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Canon, Abbey J.] CDC, EIS, Atlanta, GA 30333 USA. RP Canon, AJ (reprint author), CDC, EIS, Atlanta, GA 30333 USA. EM acanon@cdc.gov NR 4 TC 3 Z9 3 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 6 PY 2013 VL 62 IS 48 BP 987 EP 987 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 273WT UT WOS:000328567700004 ER PT J AU Sunderam, S Kissin, DM Crawford, S Anderson, JE Folger, SG Jamieson, DJ Barfield, WD AF Sunderam, Saswati Kissin, Dmitry M. Crawford, Sara Anderson, John E. Folger, Suzanne G. Jamieson, Denise J. Barfield, Wanda D. TI Assisted Reproductive Technology Surveillance - United States, 2010 SO MMWR SURVEILLANCE SUMMARIES LA English DT Article ID IN-VITRO FERTILIZATION; INSURANCE MANDATES; EMBRYO-TRANSFER; BIRTH-DEFECTS; INFERTILITY TREATMENTS; OVULATION STIMULATION; MULTIPLE GESTATION; PRETERM BIRTH; RISK; PREGNANCIES AB Problem/Condition: Since the first U. S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advanced technologies to overcome infertility and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which both eggs and sperm are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Women who undergo ART procedures are more likely to deliver multiple-birth infants than those who conceive naturally because more than one embryo might be transferred during a procedure. Multiple births pose substantial risks to both mothers and infants, including pregnancy complications, preterm delivery, and low birthweight infants. This report provides state-specific information on U. S. ART procedures performed in 2010 and compares infant outcomes that occurred in 2010 (resulting from procedures performed in 2009 and 2010) with outcomes for all infants born in the United States in 2010. Reporting Period Covered: 2010. Description of System: In 1996, CDC began collecting data on all ART procedures performed in fertility clinics in the United States and U. S. territories, as mandated by the Fertility Clinic Success Rate and Certification Act of 1992 (FCSRCA) (Public Law 102-493). Data are collected through the National ART Surveillance System (NASS), a web-based data collecting system developed by CDC. Results: In 2010, a total of 147,260 ART procedures performed in 443 U. S. fertility clinics were reported to CDC. These procedures resulted in 47,090 live-birth deliveries and 61,564 infants. The largest numbers of ART procedures were performed among residents of six states: California (18,524), New York (excluding New York City) (14,212), Illinois (10,110), Massachusetts (9,854), New Jersey (8,783), and Texas (8,754). These six states also had the highest number of live-birth deliveries as a result of ART procedures and together accounted for 48.0% of all ART procedures performed, 45.0% of all infants born from ART, and 45.0% of all multiple live-birth deliveries but only 34.0% of all infants born in the United States and U. S. territories. Nationally, the average number of ART procedures performed per 1 million women of reproductive age (15-44 years), which is a proxy indicator of ART use, was 2,331. In 13 states (California, Connecticut, Delaware, Hawaii, Illinois, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Virginia), this proxy measure was higher than the national rate, and in four states (Connecticut, Massachusetts, New Jersey, and New York) and the District of Columbia, it exceeded twice the national rate. Nationally, among cycles in which at least one embryo was transferred, the average number of embryos transferred increased with increasing age (2.0 among women aged <35 years, 2.4 among women aged 35-40 years, and 3.0 among women aged >40 years). Elective single-embryo transfer (eSET) rates decreased with increasing age (10.0% among women aged <35 years, 3.8% among women aged 35-40 years, and 0.6% among women aged >40 years). ESET rates also varied substantially between states (range: 0 to 45.0% among women aged <35 years). The number of ART births as a percentage of total infants born in the state or territory is considered as another measure of ART use. Overall, ART contributed to 1.5% of U. S. births (range: 0.1% in Guam to 4.8% in Massachusetts) with the highest rates (>3.5% of all infants born) observed in four states (Connecticut, Massachusetts, New Jersey, and New York), and the District of Columbia. The proportion of ART births was <= 2.5% in the remaining states and territories. Infants conceived with ART comprised 20.0% of all multiple-birth infants (range: 0 in Guam to 40.5% in Massachusetts), 19.0% of all twin infants (range: 0 in Guam to 40.0% in Massachusetts), and 33.0% of triplet or higher order infants (range: 0 in several states to 60.0% in Arizona). Among infants conceived with ART, 46.0% were born in multiple deliveries (range: 0 in Guam to 55.4% in Utah), compared with only 3.0% of infants among all births in the general population (range: 1.3% in Guam to 4.7% in Connecticut). A substantial proportion (43.4%) of ART-conceived infants were twin infants, and a smaller proportion (3.0%) were triplets and higher order infants. Nationally, infants conceived with ART comprised 5.6% of all low birthweight (<2,500 grams) infants (range: 0 in Guam to 16.0% in Massachusetts) and 5.6% of all very low birthweight (<1,500 grams) infants (range: 0 in Guam to 15.8% in Massachusetts). Overall, among ART-conceived infants, 31.6% were low birthweight (range: 22.6% in New Hampshire to 48.2% in Puerto Rico), compared with 8.0% among all infants (range: 5.7% in Alaska to 12.6% in Puerto Rico); 5.6% of ART infants were very low birthweight (range: 1.9% in Maine to 14.3% in Montana), compared with 1.4% among all infants (range: 0.9% in Alaska to 2.3% in the District of Columbia). Finally, ART-conceived infants comprised 4.4% of all infants born preterm (<37 weeks; range: 0 in Guam to 13.3% in Massachusetts) and 4.9% of all infants born very preterm (<32 weeks; range: 0 in Guam to 16.2% in Massachusetts). Overall, among infants conceived with ART, 36.6% were born preterm (range: 23.6% in New Hampshire to 56.8% in Wyoming), compared with 12.0% among all infants born in the general population (range: 8.4% in Vermont to 17.9% in Guam); 6.6% of ART infants were born very preterm (range: 0 in Maine to 14.5% in Puerto Rico), compared with 2.0% among all infants born in the general population (range: 1.3% in Alaska to 3.0% in the District of Columbia). Interpretation: The percentage of infants conceived with ART varied considerably by state and territory (range: 0.1% to 4.8%). In most states, multiples from ART comprised a substantial proportion of all twin, triplet, and higher-order infants born in the state, and the rates of low birthweight and preterm infants were disproportionately higher among ART infants than in the birth population overall. Even among women aged <35 years, for whom single embryo transfers should be considered (particularly in patients with a favorable prognosis) according to American Society of Reproductive Medicine (ASRM) guidelines, on average, two embryos were transferred per cycle in ART procedures, influencing the overall multiple infant rates in the United States. ART use per population unit was distributed disproportionately in the United States, with only 13 states showing ART use above the national rate, which might suggest barriers to ART services in the remaining states. Of the four states (Illinois, Massachusetts, New Jersey, and Rhode Island) with comprehensive statewide-mandated health insurance coverage for ART procedures (e. g., coverage for at least four cycles of IVF), three states (Illinois, Massachusetts, and New Jersey) also had rates of ART use >1.5 times the national level. This type of mandated insurance has been associated with greater use of ART and might account for the differences observed in other states. Public Health Actions: Reducing the number of embryos transferred per ART procedure among all age groups and promotion of eSET procedures, when clinically appropriate, is needed to reduce multiple births, including twin births, and related adverse consequences of ART. Improved patient education and counseling on the risks of twins might be useful in reducing twin births because twins account for the majority of multiples. Although ART contributes to increasing rates of multiple births, it does not explain all of the increases, and therefore the possible role of non-ART fertility treatments warrants further study. C1 [Sunderam, Saswati; Kissin, Dmitry M.; Crawford, Sara; Anderson, John E.; Folger, Suzanne G.; Jamieson, Denise J.; Barfield, Wanda D.] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Sunderam, S (reprint author), CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM zga0@cdc.gov NR 48 TC 41 Z9 49 U1 0 U2 11 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 1545-8636 J9 MMWR SURVEILL SUMM JI MMWR Surv. Summ. PD DEC 6 PY 2013 VL 62 IS 9 BP 1 EP 24 PG 24 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 263OB UT WOS:000327816800001 PM 24304902 ER PT J AU Rimmelzwaan, GF Katz, JM AF Rimmelzwaan, Guus F. Katz, Jacqueline M. TI Immune responses to infection with H5N1 influenza virus SO VIRUS RESEARCH LA English DT Article DE Influenza A H5N1 virus; Infection; Immune response ID CROSS-PROTECTIVE IMMUNITY; TO-PERSON TRANSMISSION; AVIAN-INFLUENZA; A H5N1; MONOCLONAL-ANTIBODY; SEROLOGIC ASSAYS; CELL RESPONSES; HONG-KONG; NEUTRALIZING ANTIBODIES; RECEPTOR SPECIFICITY AB Influenza A H5N1 viruses remain a substantial threat to global public health. In particular, the expanding genetic diversity of H5N1 viruses and the associated risk for human adaptation underscore the importance of better understanding host immune responses that may protect against disease or infection. Although much emphasis has been placed on investigating early virus-host interactions and the induction of innate immune responses, little is known of the consequent adaptive immune response to H5N1 virus infection. In this review, we describe the H5N1 virus-specific and cross-reactive antibody and T cell responses in humans and animal models. Data from limited studies suggest that although initially robust, there is substantial waning of the serum antibody responses in survivors of H5N1 virus infection. Characterization of monoclonal antibodies generated from memory B cells of survivors of H5N1 virus infection has provided an understanding of the fine specificity of the human antibody response to H5N1 virus infection and identified strategies for immunotherapy. Human T cell responses induced by infection with seasonal influenza viruses are directed to relatively conserved internal proteins and cross-react with the H5N1 subtype. A role for T cell-based heterosubtypic immunity against H5N1 viruses is suggested in animal studies. Further studies on adaptive immune responses to H5N1 virus infection in both humans and animals are needed to inform the design of optimal immunological treatment and prevention modalities. Published by Elsevier B.V. C1 [Rimmelzwaan, Guus F.] Erasmus MC, Virosci Lab, Rotterdam, Netherlands. [Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Katz, JM (reprint author), Influenza Div, MS G-16,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM JKatz@cdc.gov NR 103 TC 3 Z9 3 U1 1 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 EI 1872-7492 J9 VIRUS RES JI Virus Res. PD DEC 5 PY 2013 VL 178 IS 1 BP 44 EP 52 DI 10.1016/j.virusres.2013.05.011 PG 9 WC Virology SC Virology GA 273GA UT WOS:000328522100007 PM 23735534 ER PT J AU Belser, JA Tumpey, TM AF Belser, Jessica A. Tumpey, Terrence M. TI H5N1 pathogenesis studies in mammalian models SO VIRUS RESEARCH LA English DT Article DE Influenza; H5N1; Pathogenesis; Mice; Mammalian; Ferret; Avian influenza ID INFLUENZA-A-VIRUS; SINGLE-AMINO-ACID; RESPIRATORY-DISTRESS-SYNDROME; INNATE IMMUNE-RESPONSES; CENTRAL-NERVOUS-SYSTEM; GENE PROTECTS MICE; VIRAL NS1 PROTEIN; ACUTE LUNG INJURY; HONG-KONG; MOUSE MODEL AB H5N1 influenza viruses are capable of causing severe disease and death in humans, and represent a potential pandemic subtype should they acquire a transmissible phenotype. Due to the expanding host and geographic range of this virus subtype, there is an urgent need to better understand the contribution of both virus and host responses following H5N1 virus infection to prevent and control human disease. The use of mammalian models, notably the mouse and ferret, has enabled the detailed study of both complex virus-host interactions as well as the contribution of individual viral proteins and point mutations which influence virulence. In this review, we describe the behavior of H5N1 viruses which exhibit high and low virulence in numerous mammalian species, and highlight the contribution of inoculation route to virus pathogenicity. The involvement of host responses as studied in both inbred and outbred mammalian models is discussed. The roles of individual viral gene products and molecular determinants which modulate the severity of H5N1 disease in vivo are presented. This research contributes not only to our understanding of influenza virus pathogenesis, but also identifies novel preventative and therapeutic targets to mitigate the disease burden caused by avian influenza viruses. Published by Elsevier B.V. C1 [Belser, Jessica A.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. RP Tumpey, TM (reprint author), Influenza Div, MS G-16,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM tft9@cdc.gov NR 223 TC 11 Z9 11 U1 2 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 EI 1872-7492 J9 VIRUS RES JI Virus Res. PD DEC 5 PY 2013 VL 178 IS 1 BP 168 EP 185 DI 10.1016/j.virusres.2013.02.003 PG 18 WC Virology SC Virology GA 273GA UT WOS:000328522100017 PM 23458998 ER PT J AU Kulkarni, AD Jamieson, DJ Jones, HW Kissin, DM Gallo, MF Macaluso, M Adashi, EY AF Kulkarni, Aniket D. Jamieson, Denise J. Jones, Howard W., Jr. Kissin, Dmitry M. Gallo, Maria F. Macaluso, Maurizio Adashi, Eli Y. TI Fertility Treatments and Multiple Births in the United States SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ASSISTED-REPRODUCTIVE-TECHNOLOGY; SINGLE-EMBRYO TRANSFER; OVULATION STIMULATION; INSURANCE-COVERAGE; AMERICAN-SOCIETY; PREGNANCIES; INFERTILITY; OUTCOMES; RATES; NUMBER AB BackgroundThe advent of fertility treatments has led to an increase in the rate of multiple births in the United States. However, the trends in and magnitude of the contribution of fertility treatments to the increase are uncertain. MethodsWe derived the rates of multiple births after natural conception from data on distributions of all births from 1962 through 1966 (before fertility treatments were available). Publicly available data on births from 1971 through 2011 were used to determine national multiple birth rates, and data on in vitro fertilization (IVF) from 1997 through 2011 were used to estimate the annual proportion of multiple births that were attributable to IVF and to non-IVF fertility treatments, after adjustment for maternal age. Trends in multiple births were examined starting from 1998, the year when clinical practice guidelines for IVF were developed with an aim toward reducing the incidence of multiple births. ResultsWe estimated that by 2011, a total of 36% of twin births and 77% of triplet and higher-order births resulted from conception assisted by fertility treatments. The observed incidence of twin births increased by a factor of 1.9 from 1971 to 2009. The incidence of triplet and higher-order births increased by a factor of 6.7 from 1971 to 1998 and decreased by 29% from 1998 to 2011. This decrease coincided with a 70% reduction in the transfer of three or more embryos during IVF (P<0.001) and a 33% decrease in the proportion of triplet and higher-order births attributable to IVF (P<0.001). ConclusionsOver the past four decades, the increased use of fertility treatments in the United States has been associated with a substantial rise in the rate of multiple births. The rate of triplet and higher-order births has declined over the past decade in the context of a reduction in the transfer of three or more embryos during IVF. (Funded by the Centers for Disease Control and Prevention.) C1 [Kulkarni, Aniket D.; Jamieson, Denise J.; Kissin, Dmitry M.; Gallo, Maria F.] Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Jones, Howard W., Jr.] Johns Hopkins Sch Med, Baltimore, MD USA. [Jones, Howard W., Jr.] Eastern Virginia Med Sch, Norfolk, VA 23501 USA. [Macaluso, Maurizio] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA. [Adashi, Eli Y.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. RP Kulkarni, AD (reprint author), Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mailstop F-74, Atlanta, GA 30341 USA. EM eof0@cdc.gov RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 FU Centers for Disease Control and Prevention FX Funded by the Centers for Disease Control and Prevention. NR 41 TC 68 Z9 72 U1 1 U2 12 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 5 PY 2013 VL 369 IS 23 BP 2218 EP 2225 DI 10.1056/NEJMoa1301467 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 263II UT WOS:000327801100008 PM 24304051 ER PT J AU McCarthy, NL Gee, J Lin, ND Thyagarajan, V Pan, Y Su, S Turnbull, B Chan, KA Weintraub, E AF McCarthy, Natalie L. Gee, Julianne Lin, Nancy D. Thyagarajan, Veena Pan, Yi Su, Sue Turnbull, Bruce Chan, K. Arnold Weintraub, Eric TI Evaluating the safety of influenza vaccine using a claims-based health system SO VACCINE LA English DT Article DE Vaccine safety; Claims; Influenza; H1N1 ID GUILLAIN-BARRE-SYNDROME; EVENT REPORTING SYSTEM; DATALINK PROJECT; ADVERSE EVENTS; CHILDREN; SURVEILLANCE; RECEIPT; SIGNAL; H1N1; RISK AB Introduction: As part of the Centers for Disease Control and Prevention's monitoring and evaluation activities for influenza vaccines, we examined relationships between influenza vaccination and selected outcomes in the 2009-2010 and 2010-2011 influenza seasons in a claims-based data environment. Methods: We included patients with claims for trivalent influenza vaccine (TIV) and/or 2009 pandemic influenza A H1N1 vaccine (H1N1) during the 2009-2010 and 2010-2011 influenza seasons. Patients were followed for several pre-specified outcomes identified in claims. Seizures and Guillain-Barre Syndrome were selected a priori for medical record confirmation. We estimated incidence rate ratios (IRR) using a self-controlled risk interval (SCRI) or a historical comparison design. Outcomes with elevated IRRs, not selected a priori for medical record review, were further investigated with review of claims histories surrounding the outcome date to determine whether the potential event could be ruled-out or attributed to other causes based on the pattern of medical care. Results: In the 2009-2010 season, no significant increased risks for outcomes following H1 N1 vaccination were observed. Following TIV administration, the IRR for peripheral nervous system disorders and neuropathy was slightly elevated (1.07,95% Cl: 1.01-1.13). The IRR for anaphylaxis following TIV was 28.55 (95% Cl: 3.57-228.44). After further investigation of claims histories, the majority of potential anaphylaxis cases had additional claims around the time of the event indicating alternate explanatory factors or diagnoses. In the 2010-2011 season following TIV administration, a non-significant elevated IRR for anaphylaxis was observed with no other significant outcome findings. Conclusion: After claims history review, we ultimately found no increased outcome risk following administration of 998,881 TIV and 538,257 H1N1 vaccine doses in the 2009-2010 season, and 1,158,932 TIV doses in the 2010-2011 season. Published by Elsevier Ltd. C1 [McCarthy, Natalie L.; Gee, Julianne; Pan, Yi; Weintraub, Eric] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Lin, Nancy D.; Turnbull, Bruce] Optum Epidemiol, Waltham, MA 02451 USA. [Thyagarajan, Veena; Su, Sue] Optum Epidemiol, Ann Arbor, MI 48108 USA. [Chan, K. Arnold] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan. [Chan, K. Arnold] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan. RP McCarthy, NL (reprint author), CDC, 1600 Clifton Rd,MS-D26, Atlanta, GA 30333 USA. EM nmccarthy@cdc.gov; dzg2@cdc.gov; nancy.lin@optum.com; veena.thyagarajan@optum.com; jnu5@cdc.gov; yingsue@yahoo.com; bruce.turnbull@optum.com; k.a.chan@post.harvard.edu; eiw8@cdc.gov OI Chan, Kinwei/0000-0001-8161-1986 FU America's Health Insurance Plans; Centers for Disease Control and Prevention [200-2002-00732] FX This study was supported by a contract with America's Health Insurance Plans, funded by the Centers for Disease Control and Prevention (contract number: 200-2002-00732). Ms. Thyagarajan, Mr. Turnbull and Dr. Lin are employees of Optum. Dr. Chan and Ms. Su were employees of Optum at the time this study was conducted. Ms. Gee, Ms. McCarthy, and Mr. Weintraub are employees of the Centers for Disease Control and Prevention. NR 16 TC 5 Z9 5 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 5 PY 2013 VL 31 IS 50 BP 5975 EP 5982 DI 10.1016/j.vaccine.2013.10.031 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 268PA UT WOS:000328181800009 PM 24148577 ER PT J AU Thyagarajan, V Su, S Gee, J Duffy, J McCarthy, NL Chan, KA Weintraub, ES Lin, ND AF Thyagarajan, Veena Su, Sue Gee, Julianne Duffy, Jonathan McCarthy, Natalie L. Chan, K. Arnold Weintraub, Eric S. Lin, Nancy D. TI Identification of seizures among adults and children following influenza vaccination using health insurance claims data SO VACCINE LA English DT Article DE Vaccine safety; Seizure; ICD-9 diagnosis codes; Positive predictive value; Large electronic healthcare database ID FEBRILE SEIZURES; SAFETY SURVEILLANCE; RISK; PROJECT; MEASLES; MUMPS; IMMUNIZATION; CONVULSION; PERTUSSIS; EPILEPSY AB Introduction: Post-licensure surveillance of adverse events following vaccination or prescription drug use often relies on electronic healthcare data to efficiently detect and evaluate safety signals. The accuracy of seizure-related diagnosis codes in identifying true incident seizure events in vaccine safety studies is influenced by factors such as clinical setting of diagnosis and age. To date, most studies of post-vaccination seizure have focused on pediatric populations. More information is needed on how well seizure can be identified in adults and children using algorithms that rely on electronic healthcare data. Methods: This validation study was part of a larger safety study of influenza vaccination during the 2009-2010 and 2010-2011 influenza seasons. Children and adults receiving influenza vaccination were drawn from an administrative claims database of a large United States healthcare insurer. Potential seizure events were identified using an algorithm of ICD-9 diagnosis codes associated with an emergency department (ED) visit or hospitalization within pre-specified risk windows following influenza vaccination. Seizure events were confirmed through medical record review. The positive predictive value (PPV) of the algorithm was calculated within each diagnostic setting and stratified by age group, ICD-9 code group, and sex. Results: Review confirmed 113 out of 176 potential seizure events. The PPVs were higher in the ED setting (93.9%) than in the inpatient setting (38.3%). The PPVs by age varied within the ED setting (98.2% in <7 years, 76.9% in 7-24 years, 92.3% in >= 25 years) and within the inpatient setting (64.7% in <7 years, 33.3% in 7-24 years, 32.3% in >= 25 years). Conclusions: Our algorithm for identification of seizure events using claims data had a high level of accuracy in the emergency department setting in young children and older adults and a lower, but acceptable, level of accuracy in older children and young adults. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Thyagarajan, Veena; Su, Sue] Optum Epidemiol, Ann Arbor, MI 48108 USA. [Gee, Julianne; Duffy, Jonathan; McCarthy, Natalie L.; Weintraub, Eric S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Chan, K. Arnold] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan. [Chan, K. Arnold] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan. [Lin, Nancy D.] Optum Epidemiol, Waltham, MA 02451 USA. RP Thyagarajan, V (reprint author), Optum Epidemiol, 315 E Eisenhower Pkwy Suite 305, Ann Arbor, MI 48108 USA. EM veena.thyagarajan@optum.com; dzg2@cdc.gov; jduffy@cdc.gov; gvz7@cdc.gov; k.a.chan@post.harvard.edu; eiw8@cdc.gov; nancy.lin@optum.com OI Chan, Kinwei/0000-0001-8161-1986 FU Centers for Disease Control and Prevention [200-2002-00732] FX This study was conducted by Optum Epidemiology and sponsored through a subcontract with America's Health Insurance Plans (AHIP) under contract number 200-2002-00732 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 25 TC 0 Z9 0 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 5 PY 2013 VL 31 IS 50 BP 5997 EP 6002 DI 10.1016/j.vaccine.2013.10.026 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 268PA UT WOS:000328181800012 PM 24148576 ER PT J AU Cho, BH Stoecker, C Link-Gelles, R Moore, MR AF Cho, Bo-Hyun Stoecker, Charles Link-Gelles, Ruth Moore, Matthew R. TI Cost-effectiveness of administering 13-valent pneumococcal conjugate vaccine in addition to 23-valent pneumococcal polysaccharide vaccine to adults with immunocompromising conditions SO VACCINE LA English DT Article DE PCV13; Incremental cost-effectiveness; lmmunocompromised adults ID HIV-INFECTED ADULTS; UNITED-STATES; DIALYSIS PATIENTS; DISEASE; IMPACT; TRIAL; PNEUMONIA; OLDER; TRANSPLANTATION; IMMUNIZATION AB Background: In June, 2012 a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) was added to the recommendation for immunocompromised adults who were previously recommended to receive only 23-valent pneumococcal polysaccharide vaccine (PPSV23). PCV13 may be more effective, though it covers fewer disease-causing strains. Objective: We examined the incremental cost-effectiveness of adding one dose of PCV13 to the pre-2012 recommendation of PPSV23 for adults with 4 immunocompromising conditions who are at increased risk of pneumococcal disease: HIV/AIDS, hematologic cancer, solid organ transplants, and end stage renal disease. Methods: We used a probabilistic model following a single cohort of 302,397 immunocompromised adults. We used vaccination coverage and disease incidence data specific to each immunocompromising condition. Assumptions about PPSV23 and PCV13 vaccine effectiveness were based on two randomized controlled trials and several observational studies conducted among HIV-infected adults. Because no such studies have been conducted among other immunocompromised populations, we made further assumptions about the relative vaccine effectiveness in those groups. Cost-effectiveness ratios were determined for each condition and for all 4 groups in total. Results: Our model indicated that adding one dose of PCV13 to adults in the United States with 4 immunocompromising conditions would cost $16 million (in 2009$) but provide off-setting savings of $21 million per cohort from the societal perspective. These savings come largely from decreased medical costs among adults with end stage renal disease. This dose of PCV13 would prevent 57 cases of invasive pneumococcal disease, 619 cases of hospitalized all-cause pneumonia, avert 93 deaths, and save 1360 quality adjusted life years per cohort. Conclusion: The addition of one dose of PCVI3 to the previously recommended PPSV23 doses for adults with selected immunocompromised conditions potentially reduces both disease and costs. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Cho, Bo-Hyun; Link-Gelles, Ruth; Moore, Matthew R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Stoecker, Charles] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Global Hlth Syst & Dev, New Orleans, LA 70112 USA. RP Stoecker, C (reprint author), Tulane Univ, Sch Publ Hlth & Trop Med, Dept Global Hlth Syst & Dev, 1440 Canal St,Suite 1923, New Orleans, LA 70112 USA. EM cfstoecker@tulane.edu NR 47 TC 12 Z9 13 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 5 PY 2013 VL 31 IS 50 BP 6011 EP 6021 DI 10.1016/j.vaccine.2013.10.024 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 268PA UT WOS:000328181800014 PM 24148572 ER PT J AU Ruckart, PZ Bove, FJ Maslia, M AF Ruckart, Perri Zeitz Bove, Frank J. Maslia, Morris TI Evaluation of exposure to contaminated drinking water and specific birth defects and childhood cancers at Marine Corps Base Camp Lejeune, North Carolina: a case-control study SO ENVIRONMENTAL HEALTH LA English DT Article DE Neural tube defects; Childhood cancers; Environmental epidemiology; Trichloroethylene; Water ID MATERNAL OCCUPATIONAL-EXPOSURE; NEURAL-TUBE DEFECTS; CONGENITAL-MALFORMATIONS; CHLORINATED SOLVENTS; ORGANIC-SOLVENTS; ORAL CLEFTS; RISK; LEUKEMIA; PREGNANCY; TETRACHLOROETHYLENE AB Background: Drinking water supplies at Marine Corps Base Camp Lejeune were contaminated with trichloroethylene, tetrachloroethylene, benzene, vinyl chloride and trans-1,2-dichloroethylene during 1968 through 1985. Methods: We conducted a case control study to determine if children born during 1968-1985 to mothers with residential exposure to contaminated drinking water at Camp Lejeune during pregnancy were more likely to have childhood hematopoietic cancers, neural tube defects (NTDs), or oral clefts. For cancers, exposures during the first year of life were also evaluated. Cases and controls were identified through a survey of parents residing on base during pregnancy and confirmed by medical records. Controls were randomly sampled from surveyed participants who had a live birth without a major birth defect or childhood cancer. Groundwater contaminant fate and transport and distribution system models provided estimates of monthly levels of drinking water contaminants at mothers' residences. Magnitude of odds ratios (ORs) was used to assess associations. Confidence intervals (CIs) were used to indicate precision of ORs. We evaluated parental characteristics and pregnancy history to assess potential confounding. Results: Confounding was negligible so unadjusted results were presented. For NTDs and average 1st trimester exposures, ORs for any benzene exposure and for trichloroethylene above 5 parts per billion were 4.1 (95% CI: 1.4-12.0) and 2.4 (95% CI: 0.6-9.6), respectively. For trichloroethylene, a monotonic exposure response relationship was observed. For childhood cancers and average 1st trimester exposures, ORs for any tetrachloroethylene exposure and any vinyl chloride exposure were 1.6 (95% CI: 0.5-4.8), and 1.6 (95% CI: 0.5-4.7), respectively. The study found no evidence suggesting any other associations between outcomes and exposures. Conclusion: Although CIs were wide, ORs suggested associations between drinking water contaminants and NTDs. ORs suggested weaker associations with childhood hematopoietic cancers. C1 [Ruckart, Perri Zeitz; Bove, Frank J.] Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA 30341 USA. [Maslia, Morris] Agcy Tox Subst & Dis Registry, Div Community Hlth Invest, Atlanta, GA 30341 USA. RP Ruckart, PZ (reprint author), Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, 4770 Buford Highway,MS F-58, Atlanta, GA 30341 USA. EM pruckart@cdc.gov NR 38 TC 13 Z9 16 U1 2 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD DEC 4 PY 2013 VL 12 AR 104 DI 10.1186/1476-069X-12-104 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 297VT UT WOS:000330283900001 PM 24304547 ER PT J AU Nyendak, MR Park, B Null, MD Baseke, J Swarbrick, G Mayanja-Kizza, H Nsereko, M Johnson, DF Gitta, P Okwera, A Goldberg, S Bozeman, L Johnson, JL Boom, WH Lewinsohn, DA Lewinsohn, DM AF Nyendak, Melissa R. Park, Byung Null, Megan D. Baseke, Joy Swarbrick, Gwendolyn Mayanja-Kizza, Harriet Nsereko, Mary Johnson, Denise F. Gitta, Phineas Okwera, Alphonse Goldberg, Stefan Bozeman, Lorna Johnson, John L. Boom, W. Henry Lewinsohn, Deborah A. Lewinsohn, David M. CA TB Res Unit TB Trials Consortium TI Mycobacterium tuberculosis Specific CD8(+) T Cells Rapidly Decline with Antituberculosis Treatment SO PLOS ONE LA English DT Article ID INTERFERON-GAMMA RESPONSES; PULMONARY TUBERCULOSIS; IFN-GAMMA; ANTIGEN; INFECTION; MALNUTRITION; INDIVIDUALS; BIOMARKERS; SIGNATURE; REVERSION AB Rationale: Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium tuberculosis (Mtb) specific CD8(+) T cells, by virtue of detecting intracellular infection, could be a surrogate marker of response to therapy and would decrease during effective antituberculosis treatment. Objectives: We sought to determine the relationship of Mtb specific CD4(+) T cells and CD8(+) T cells with duration of antituberculosis treatment. Materials and Methods: We performed a prospective cohort study, enrolling between June 2008 and August 2010, of HIV-uninfected Ugandan adults (n = 50) with acid-fast bacillus smear-positive, culture confirmed pulmonary TB at the onset of antituberculosis treatment and the Mtb specific CD4(+) and CD8(+) T cell responses to ESAT-6 and CFP-10 were measured by IFN-gamma ELISPOT at enrollment, week 8 and 24. Results: There was a significant difference in the Mtb specific CD8(+) T response, but not the CD4(+) T cell response, over 24 weeks of antituberculosis treatment (p<0.0001), with an early difference observed at 8 weeks of therapy (p = 0.023). At 24 weeks, the estimated Mtb specific CD8(+) T cell response decreased by 58%. In contrast, there was no significant difference in the Mtb specific CD4(+) T cell during the treatment. The Mtb specific CD4(+) T cell response, but not the CD8(+) response, was negatively impacted by the body mass index. Conclusions: Our data provide evidence that the Mtb specific CD8(+) T cell response declines with antituberculosis treatment and could be a surrogate marker of response to therapy. Additional research is needed to determine if the Mtb specific CD8(+) T cell response can detect early treatment failure, relapse, or to predict disease progression. C1 [Nyendak, Melissa R.; Lewinsohn, David M.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. [Park, Byung] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA. [Null, Megan D.; Lewinsohn, Deborah A.] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97201 USA. [Baseke, Joy; Mayanja-Kizza, Harriet; Nsereko, Mary; Gitta, Phineas; Okwera, Alphonse; Johnson, John L.; Boom, W. Henry] Uganda Case Western Reserve Univ, Res Collaborat, Kampala, Uganda. [Swarbrick, Gwendolyn; Lewinsohn, David M.] Portland VA Med Ctr, Dept Med, Portland, OR USA. [Mayanja-Kizza, Harriet] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda. [Johnson, Denise F.; Johnson, John L.; Boom, W. Henry] Case Western Reserve Univ, TB Res Unit, Cleveland, OH 44106 USA. [Goldberg, Stefan; Bozeman, Lorna] Ctr Dis Control & Prevent, TB Trials Consortium, Natl Ctr HIV AIDS Viral Hepatitis & TB Prevent, Div TB Eliminat, Atlanta, GA USA. RP Nyendak, MR (reprint author), Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. EM nyendakm@ohsu.edu; lewinsod@ohsu.edu RI Lewinsohn, David/I-4936-2013 OI Mayanja-Kizza, Harriet/0000-0002-9297-6208; Lewinsohn, David/0000-0001-9906-9494 FU NIH [HHSN266200400081C, HHSN272200900053C]; National Center for Research Resources [KL2RR024141]; VA Merit Review Grant; Portland VA Medical Center; Tuberculosis Research Unit at Case Western Reserve University; United States National Institute of Allergy and Infectious Diseases, National Institutes of Health and Human Services [HHSN266200700022C/NO1-AI-70022]; US Government Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC) [200-2009-32598] FX This work was supported in part by the following agency and institutes: NIH grants HHSN266200400081C and HHSN272200900053C, The National Center for Research Resources KL2RR024141, VA Merit Review Grant and the Portland VA Medical Center. This work was also supported by the Tuberculosis Research Unit at Case Western Reserve University, established with funds from the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health and Human Services, under contract number HHSN266200700022C/NO1-AI-70022 and the Tuberculosis Trials Consortium sponsored by the US Government Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), contract number 200-2009-32598. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC or the Agency for Toxic Substances and Disease Registry. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 15 Z9 15 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 4 PY 2013 VL 8 IS 12 AR e81564 DI 10.1371/journal.pone.0081564 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 265KD UT WOS:000327949300095 PM 24324704 ER PT J AU Hales, CM Harpaz, R Joesoef, MR Bialek, SR AF Hales, Craig M. Harpaz, Rafael Joesoef, M. Riduan Bialek, Stephanie R. TI Examination of Links Between Herpes Zoster Incidence and Childhood Varicella Vaccination SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID UNITED-STATES; RISK-FACTORS; ADMINISTRATIVE DATABASE; COMPLICATION RATES; VIRUS-INFECTIONS; OLDER-ADULTS; EPIDEMIOLOGY; SHINGLES; CHICKENPOX; EXPOSURE AB Background: Introduction of a universal varicella vaccine program for U.S. children in 1996 sparked concern that less-frequent exposure to varicella would decrease external boosting of immunity to varicella zoster virus and thereby increase incidence of herpes zoster (HZ). Objective: To determine whether the varicella vaccination program has influenced trends in HZ incidence in the U.S. population older than 65 years. Design: Retrospective study of Medicare claims. Setting: Medicare, 1992 through 2010. Participants: 2 848 765 beneficiaries older than 65 years. Measurements: Annual HZ incidence from 1992 through 2010; rate ratios (RRs) for HZ incidence by age, sex, and race or ethnicity; and state-level varicella vaccination coverage. Results: 281 317 incident cases of HZ occurred. Age- and sex-standardized HZ incidence increased 39% from 10.0 per 1000 person-years in 1992 to 13.9 per 1000 person-years in 2010 with no evidence of a statistically significant change in the rate of in-crease after introduction of the varicella vaccination program. Before introduction of this program, HZ incidence was higher in women (RR, 1.21 [95% CI, 1.19 to 1.24]) than men and was lower in black persons (RR, 0.51 [CI, 0.48 to 0.53]) and Hispanic persons (RR, 0.76 [CI, 0.72 to 0.81]) than white persons. In a model adjusted for sex, age, and calendar year from 1997 to 2010, HZ incidence did not vary by state varicella vaccination coverage (RR, 0.9998 [CI, 0.9993 to 1.0003]). Limitation: Uncertain level and consistency of health-seeking behavior and access and uncertain accuracy of disease coding. Conclusion: Age- specific HZ incidence increased in the U.S. population older than 65 years even before implementation of the childhood varicella vaccination program. Introduction and widespread use of the vaccine did not seem to affect this increase. This information is reassuring for countries considering universal varicella vaccination. C1 [Hales, Craig M.; Harpaz, Rafael; Joesoef, M. Riduan; Bialek, Stephanie R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Hales, CM (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mail Stop A-34, Atlanta, GA 30333 USA. EM chales@cdc.gov NR 49 TC 34 Z9 36 U1 6 U2 13 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 3 PY 2013 VL 159 IS 11 BP 739 EP + DI 10.7326/0003-4819-159-11-201312030-00006 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA 276EN UT WOS:000328731000003 PM 24297190 ER PT J AU Khabbaz, RF AF Khabbaz, Rima F. TI Still Learning From SARS SO ANNALS OF INTERNAL MEDICINE LA English DT Editorial Material ID ACUTE RESPIRATORY SYNDROME; CORONAVIRUS; INFECTION; OUTBREAK C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Khabbaz, RF (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop D12, Atlanta, GA 30333 USA. EM rfk1@cdc.gov NR 10 TC 3 Z9 3 U1 0 U2 3 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 3 PY 2013 VL 159 IS 11 BP 780 EP + DI 10.7326/0003-4819-159-11-201312030-00011 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 276EN UT WOS:000328731000008 PM 24297195 ER PT J AU Carignan, CC Heiger-Bernays, W McClean, MD Roberts, SC Stapleton, HM Sjodin, A Webster, TF AF Carignan, Courtney C. Heiger-Bernays, Wendy McClean, Michael D. Roberts, Simon C. Stapleton, Heather M. Sjoedin, Andreas Webster, Thomas F. TI Flame Retardant Exposure among Collegiate United States Gymnasts SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; IN-HOUSE DUST; POLYCHLORINATED-BIPHENYLS; SERUM CONCENTRATIONS; BREAST-MILK; PBDES; ASSOCIATIONS; ENVIRONMENT; POPULATION; PREGNANCY AB Gymnastics training facilities contain large volumes of polyurethane foam, a material that often contains additive flame retardants such as PentaBDE. While investigations of human exposure to flame retardants have focused on the general population, potentially higher than background exposures may occur in gymnasts and certain occupational groups. Our objectives were to compare PentaBDE body burden among gymnasts to the general United States population and characterize flame retardants levels in gym equipment, air, and dust. We recruited 11 collegiate female gymnasts (ages 18-22) from one gym in the eastern United States. The geometric mean (GM) concentration of BDE-153 in gymnast sera (32.5 ng/g lipid) was 4-6.5 times higher than in the general United States population groups. Median concentrations of PentaBDE, TBB, and TBPH in paired handwipe samples were 2-3 times higher after practice compared to before, indicating the gymnasts contacted these flame retardants during practice. GM concentrations of PentaBDE, TBB, and TBPH were 1-3 orders of magnitude higher in gym air and dust than in residences. Our findings suggest that these collegiate gymnasts experienced higher exposures to PentaBDE flame retardants compared to the general United States population and that gymnasts may also have increased exposure to other additive flame retardants used in polyurethane foam such as TBB and TBPH. C1 [Carignan, Courtney C.; Heiger-Bernays, Wendy; McClean, Michael D.; Webster, Thomas F.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Roberts, Simon C.; Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Sjoedin, Andreas] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. RP Carignan, CC (reprint author), Dartmouth Coll, 78 Coll St HB6044, Hanover, NH 03755 USA. EM courtney.c.carignan@dartmouth.edu RI Sjodin, Andreas/F-2464-2010; McClean, Michael/J-2934-2015 FU National Institute of Environmental Health Sciences (NIEHS) [T32ES014562, R01ES015829, R01ES016099] FX We thank the study participants, gyms, and coaches, as well as Scott Harris and Kelly Hartnett. We thank Jennifer Ames, Ashley Miller, and Brittany Weldon for their assistance with the sampling effort and thank Adam Carignan for the TOC artwork. This research was supported in part by grants T32ES014562 (CC), R01ES015829, and R01ES016099 (HS) from the National Institute of Environmental Health Sciences (NIEHS). The content is solely the responsibility of the authors and does not necessarily represent the official position of the Centers for Disease Control and Prevention or the NIEHS. NR 38 TC 23 Z9 24 U1 2 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 3 PY 2013 VL 47 IS 23 BP 13848 EP 13856 DI 10.1021/es40378681 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 266CH UT WOS:000327999400079 PM 24195753 ER PT J AU Kuzmina, NA Lemey, P Kuzmin, IV Mayes, BC Ellison, JA Orciari, LA Hightower, D Taylor, ST Rupprecht, CE AF Kuzmina, Natalia A. Lemey, Philippe Kuzmin, Ivan V. Mayes, Bonny C. Ellison, James A. Orciari, Lillian A. Hightower, Dillon Taylor, Steven T. Rupprecht, Charles E. TI The Phylogeography and Spatiotemporal Spread of South-Central Skunk Rabies Virus SO PLOS ONE LA English DT Article ID MOLECULAR EPIDEMIOLOGY; STRIPED SKUNKS; POPULATION-DYNAMICS; NORTH-AMERICA; SELECTION; EPIZOOTIOLOGY; MUTATIONS; EVOLUTION; EXPANSION; INFERENCE AB The south-central skunk rabies virus (SCSK) is the most broadly distributed terrestrial viral lineage in North America. Skunk rabies has not been efficiently targeted by oral vaccination campaigns and represents a natural system of pathogen invasion, yielding insights to rabies emergence. In the present study we reconstructed spatiotemporal spread of SCSK in the whole territory of its circulation using a combination of Bayesian methods. The analysis based on 241 glycoprotein gene sequences demonstrated that SCSK is much more divergent phylogenetically than was appreciated previously. According to our analyses the SCSK originated in the territory of Texas similar to 170 years ago, and spread geographically during the following decades. The wavefront velocity in the northward direction was significantly greater than in the eastward and westward directions. Rivers (except the Mississippi River and Rio Grande River) did not constitute significant barriers for epizootic spread, in contrast to deserts and mountains. The mean dispersal rate of skunk rabies was lower than that of the raccoon and fox rabies. Viral lineages circulate in their areas with limited evidence of geographic spread during decades. However, spatiotemporal reconstruction shows that after a long period of stability the dispersal rate and wavefront velocity of SCSK are increasing. Our results indicate that there is a need to develop control measures for SCSK, and suggest how such measure can be implemented most efficiently. Our approach can be extrapolated to other rabies reservoirs and used as a tool for investigation of epizootic patterns and planning interventions towards disease elimination. C1 [Kuzmina, Natalia A.; Kuzmin, Ivan V.; Ellison, James A.; Orciari, Lillian A.; Hightower, Dillon; Taylor, Steven T.; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Rabies Program, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Lemey, Philippe] Katholieke Univ Leuven, Dept Microbiol & Immunol, Louvain, Belgium. [Mayes, Bonny C.] Texas Dept State Hlth Serv, Zoonosis Control Branch, Austin, TX USA. [Rupprecht, Charles E.] Ross Univ, Sch Vet Med, Dept Epidemiol & Publ Hlth, Basseterre, St Kitts, W Ind Assoc St. RP Kuzmina, NA (reprint author), Ctr Dis Control & Prevent, Rabies Program, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM natakuzmina@yandex.ru FU European Union [278433-PREDEMICS]; ERC [260864] FX PL acknowledges funding from the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement no. 278433-PREDEMICS and ERC Grant agreement no. 260864. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 5 Z9 5 U1 1 U2 23 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 3 PY 2013 VL 8 IS 12 AR e82348 DI 10.1371/journal.pone.0082348 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 265JR UT WOS:000327947800094 PM 24312657 ER PT J AU McCarthy, NL Irving, S Donahue, JG Weintraub, E Gee, J Belongia, E Baggs, J AF McCarthy, Natalie L. Irving, Stephanie Donahue, James G. Weintraub, Eric Gee, Julianne Belongia, Edward Baggs, James TI Vaccination coverage levels among children enrolled in the Vaccine Safety Datalink SO VACCINE LA English DT Article DE Vaccine; Vaccine coverage; Vaccine Safety Datalink ID AGED 19-35 MONTHS; UNITED-STATES; PARENTAL REFUSAL; HEALTH-INSURANCE; TIMELINESS; EXEMPTIONS; MORBIDITY; MORTALITY; INFECTION; SHORTAGES AB Introduction: The Vaccine Safety Datalink (VSD) is a collaborative project whose infrastructure provides comprehensive medical and immunization histories for more than 9 million adults and children annually, a predominantly insured population. This study provides the coverage rates of recommended vaccines among children 19-35 months in the VSD from 2005 through 2010. We examine the consistency in vaccine coverage levels, detect possible trends, and evaluate any effect of vaccine shortages on coverage in the VSD. Methods: We included data from all 10 VSD sites, and examined each year independently. Coverage rates were defined as the percentage of children in the VSD aged 19, 24, or 35 months in a given study year who had received the specified Advisory Committee on Immunization Practices (ACIP) recommended vaccine(s). Results: We assessed coverage on 658,154 children. The overall coverage rate for children receiving all of the specified ACIP recommended vaccines was 73%, 80%, and 78% at ages 19, 24, and 35 months respectively. The range of coverage across all ages and years was 95-97% for polio vaccine, 91-97%, for MMR vaccine, 94-97% for HepB vaccine, 81-95% for DTaP vaccine, 90-95% for varicella vaccine, 66-91% for PCV, and 93-98% for Hib vaccine. Coverage rates of 4 or more doses of PCV were relatively low in 2005 possibly due to a vaccine shortage, and increased sharply in 2007. Hib vaccine coverage was relatively stable among all ages until 2009 when rates declined among children aged 19 and 24 months also during a vaccine shortage. Conclusions: Vaccine coverage in the VSD is high, but there is a decline from 2005 to 2010. The results of this study provide benchmark data for future studies, and describe how vaccine supply shortages and resulting changes in ACIP recommendations may have affected vaccine coverage rates in the VSD. Published by Elsevier Ltd. C1 [McCarthy, Natalie L.; Weintraub, Eric; Gee, Julianne; Baggs, James] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Irving, Stephanie; Donahue, James G.; Belongia, Edward] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA. RP McCarthy, NL (reprint author), CDC, 1600 Clifton Rd,MS D26, Atlanta, GA 30333 USA. EM gvz7@cdc.gov OI Irving, Stephanie/0000-0001-7437-6797; Baggs, James/0000-0003-0757-4683 FU Vaccine Safety Datalink contract; America's Health Insurance Plans; Centers for Disease Control and Prevention FX This study was supported by the Vaccine Safety Datalink contract with America's Health Insurance Plans, funded by the Centers for Disease Control and Prevention. Thanks to the following VSD collaborators for data management and editorial assistance: Roger Baxter, Robert A. Bednarczyk, Matthew F. Daley, Lisa Jackson, Nicola Klein, Grace Lee, Marlene Lugg, Cynthia Nakasato, Saad B. Omer, Mark M. Schmidt, and VinuthaVijayadeva. NR 40 TC 4 Z9 4 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 2 PY 2013 VL 31 IS 49 BP 5822 EP 5826 DI 10.1016/j.vaccine.2013.10.011 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 274GW UT WOS:000328595800006 PM 24135576 ER PT J AU Mendeloff, J D'Alessandro, M Liu, HS Steiner, E Kopsic, J Burns, R AF Mendeloff, John D'Alessandro, Maryann Liu, Hangsheng Steiner, Elizabeth Kopsic, Jessica Burns, Rachel TI Using OSHA inspection data to analyze respirator protection program compliance SO MONTHLY LABOR REVIEW LA English DT Article AB Several million American workers wear respirators on a regular basis, and the Occupational Safety and Health Administration (OSHA) requires that nonagricultural firms have a respiratory protection program. This article uses the OSHA inspection data base to examine all inspections in manufacturing in 47 states from 1999 through 2006; the examination starts with 1999 because an expanded OSHA respiratory program standard became effective in late 1998. The article identifies all inspections and all establishments at which respiratory protection (RP) violations were cited, and it compares the prevalence of violations by industry with the prevalence reported in a recent Bureau of Labor Statistics survey of respirator use. Multivariate analyses are used to identify the roles of industry, establishment size, union status, and employee participation in the inspection on noncompliance at the inspection level and for repeated inspections at the same establishment. The authors find that the pattern of noncompliance across industries mostly mirrors the survey findings about the prevalence of requirements for respirator use, although the chemical industry has fewer violations than expected. The probability of citing an RP violation is similar across establishment size categories, except for a large drop for establishments with over 200 workers. The presence of a worker accompanying the inspector increases the probability that a respiratory program violation will be cited; the presence of a union slightly decreases it. C1 [Mendeloff, John] Univ Pittsburgh, Pittsburgh, PA 15260 USA. [Mendeloff, John] RAND Corp, Ctr Hlth & Safety Workpl, Santa Monica, CA 90406 USA. [D'Alessandro, Maryann] Ctr Dis Control & Prevent, Natl Personal Protect Technol Lab, Atlanta, GA 30333 USA. [Liu, Hangsheng; Steiner, Elizabeth; Burns, Rachel] RAND Corp, Santa Monica, CA 90406 USA. [Kopsic, Jessica] MDRC, New York, NY USA. RP Mendeloff, J (reprint author), Univ Pittsburgh, Pittsburgh, PA 15260 USA. EM jmendel@rand.org; mdalessandro@cdc.gov; Hangsheng_Liu@rand.org; Elizabeth_Steiner@rand.org; Jessica.kopsic@gmail.com; Rachel_Burns@rand.org FU National Personal Protective Technology Laboratory of the National Institute of Occupational Safety and Health; RAND Corporation Center for Health and Safety in the Workplace FX This study was supported by the National Personal Protective Technology Laboratory of the National Institute of Occupational Safety and Health through a contract with the RAND Corporation Center for Health and Safety in the Workplace. Douglas Landsittel of NPPTL provided many helpful comments. NR 15 TC 0 Z9 1 U1 0 U2 0 PU LEGAL BOOKS DEPOT PI LOS ANGELES PA PO BOX 27789, LOS ANGELES, CA 90027 USA SN 0098-1818 J9 MON LABOR REV JI Mon. Labor Rev. PD DEC 2 PY 2013 BP 1 EP 27 PG 27 WC Industrial Relations & Labor SC Business & Economics GA V40EH UT WOS:000209461400001 ER PT J AU Humphrey, CP O'Driscoll, MA Deal, NE Lindbo, DL Thieme, SC Zarate-Bermudez, MA AF Humphrey, C. P., Jr. O'Driscoll, M. A. Deal, N. E. Lindbo, D. L. Thieme, S. C. Zarate-Bermudez, M. A. TI Onsite Wastewater System Nitrogen Contributions to Groundwater in Coastal North Carolina SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID SAND AQUIFER; ESTUARY; NITRATE AB The objective of the study described in this article was to evaluate the nitrogen contributions from two onsite wastewater systems (sites 1 and 2) to groundwater and adjacent surface waters in coastal Beaufort County, North Carolina. Groundwater levels and water quality parameters including total nitrogen, nitrogen species, temperature, and pH were monitored from October 2009 to May 2010. Nitrogen was also tested in groundwater from deeper irrigation or drinking water wells from the two sites and six additional neighboring residences. Mean total nitrogen concentrations in groundwater beneath onsite wastewater systems 1 and 2 were 34.3 +/- 16.7 mg/L and 12.2 +/- 2.9 mg/L, respectively, and significantly higher than background groundwater concentrations (<1 mg/L). Groundwater in the deeper wells appeared not to be influenced by the onsite systems. Groundwater nitrogen concentrations typically decreased with distance down-gradient from the systems, but were still elevated relative to background conditions more than 15 m from the systems and near the estuary. This was a pioneering effort to better understand the link of onsite systems, the fate of nitrogen in the environment, and public health. C1 [Humphrey, C. P., Jr.] E Carolina Univ, Environm Hlth Sci Program, Greenville, NC 27858 USA. [O'Driscoll, M. A.; Thieme, S. C.] E Carolina Univ, Dept Geol Sci, Greenville, NC 27858 USA. [Deal, N. E.] North Carolina Dept Hlth & Human Serv, Raleigh, NC USA. [Lindbo, D. L.] N Carolina State Univ, Dept Soil Sci & Cooperat Extens, Raleigh, NC 27695 USA. [Zarate-Bermudez, M. A.] Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Atlanta, GA 30341 USA. RP Zarate-Bermudez, MA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-58, Atlanta, GA 30341 USA. EM mcz4@cdc.gov FU Intramural CDC HHS [CC999999] NR 22 TC 7 Z9 7 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD DEC PY 2013 VL 76 IS 5 BP 16 EP 22 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NP UT WOS:000341540200003 PM 24437045 ER PT J AU Coleman, EW Delea, KC AF Coleman, Erik W. Delea, Kristin C. TI The Use of Public Health Informatics to Improve Environmental Health Practice SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article AB NEHA strives to provide up-to-date and relevant information on environmental health and to build partnerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Control and Prevention (CDC) in every issue of the Journal. In this column, EHSB and guest authors from across CDC will highlight a variety of concerns, opportunities, challenges, and successes that we all share in enviromental public health. EHSB's objective is to strengthen the role of state, local, tribal, and national environmental health programs and professionals to anticipate, identify, and respond to adverse environmental exposures and the consequences of these exposures for human health. The conclusions in this article are those of the author(s) and do not necessarily represent the views of CDC. Erik W. Coleman is a public health informatics fellow at EHSB. Kristin C. Delea is an epidemiologist at EHSB. C1 [Coleman, Erik W.] Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Environm Hlth Serv Branch, Atlanta, GA 30341 USA. RP Coleman, EW (reprint author), Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Environm Hlth Serv Branch, 4770 Buford Highway NE,Mailstop F58, Atlanta, GA 30341 USA. EM ecoleman@cdc.gov FU Intramural CDC HHS [CC999999] NR 6 TC 1 Z9 1 U1 1 U2 8 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD DEC PY 2013 VL 76 IS 5 BP 44 EP 45 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NP UT WOS:000341540200007 PM 24437050 ER PT J AU Johnson, CH Skinner, BL Dietz, SM Blaney, D Engel, RM Lathrop, GW Hoffmaster, AR Gee, JE Elrod, MG Powell, N Walke, H AF Johnson, Crystal H. Skinner, Brianna L. Dietz, Sharon M. Blaney, David Engel, Robyn M. Lathrop, George W. Hoffmaster, Alex R. Gee, Jay E. Elrod, Mindy G. Powell, Nathaniel Walke, Henry TI Natural Infection of Burkholderia pseudomallei in an Imported Pigtail Macaque (Macaca nemestrina) and Management of the Exposed Colony SO COMPARATIVE MEDICINE LA English DT Article ID PSEUDOMONAS-PSEUDOMALLEI; INDIRECT HEMAGGLUTINATION; NEUROLOGICAL MELIOIDOSIS; MONKEY; OSTEOMYELITIS; DIAGNOSIS; GLANDERS; THAILAND; PRIMATES; ANIMALS AB Identification of the select agent Burkholderia pseudomallei in macaques imported into the United States is rare. A purpose-bred, 4.5-y-old pigtail macaque (Macaca nemestrina) imported from Southeast Asia was received from a commercial vendor at our facility in March 2012. After the initial acclimation period of 5 to 7 d, physical examination of the macaque revealed a subcutaneous abscess that surrounded the right stifle joint. The wound was treated and resolved over 3 mo. In August 2012, 2 mo after the stifle joint wound resolved, the macaque exhibited neurologic clinical signs. Postmortem microbiologic analysis revealed that the macaque was infected with B. pseudomallei. This case report describes the clinical evaluation of a B. pseudomallei-infected macaque, management and care of the potentially exposed colony of animals, and protocols established for the animal care staff that worked with the infected macaque and potentially exposed colony. This article also provides relevant information on addressing matters related to regulatory issues and risk management of potentially exposed animals and animal care staff. C1 [Johnson, Crystal H.; Skinner, Brianna L.; Lathrop, George W.; Powell, Nathaniel] Ctr Dis Control & Prevent CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Anim Resources Branch, Atlanta, GA USA. [Dietz, Sharon M.; Engel, Robyn M.] Ctr Dis Control & Prevent CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Anim Resources Branch,Lab Anim Med Residency Prog, Atlanta, GA USA. [Blaney, David; Hoffmaster, Alex R.; Gee, Jay E.; Elrod, Mindy G.; Walke, Henry] Ctr Dis Control & Prevent CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Bacterial Special Pathogens Branch, Atlanta, GA USA. RP Johnson, CH (reprint author), Icahn Sch Med Mt Sinai, Ctr Comparat Med & Surg, New York, NY 10029 USA. EM crystal.johnson@mssm.edu FU Laboratory Animal Medicine Residency Program at CDC FX We thank the managers and technicians in the Animal Resources Branch at CDC for their efforts in supporting the care of the animals housed at our facility. Special acknowledgments are also extended to Dr Jana Ritter and Dr Clifton Drew (Infectious Disease Pathology Branch, CDC) for providing necropsy and histopathology information and David Lonsway (Division of Healthcare Quality Promotion, CDC) for performing antimicrobial susceptibility testing. We also thank Ms Joanne Jones (Responsible Official, CDC); the Division of HIV-AIDS Prevention, Laboratory Branch (CDC); and the numerous people who assisted in the review of this article. Clinical care of the animals discussed in this case report was supported in part by the Laboratory Animal Medicine Residency Program at CDC. NR 43 TC 4 Z9 4 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD DEC PY 2013 VL 63 IS 6 BP 528 EP 535 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AN7VW UT WOS:000340810100010 PM 24326230 ER PT J AU Kolwaite, AR Hlady, WG Simon, MC Cadwell, BL Daley, WR Fleischauer, AT May, Z Thoroughman, D AF Kolwaite, Amy R. Hlady, W. Gary Simon, Matthew C. Cadwell, Betsy L. Daley, W. Randolph Fleischauer, Aaron T. May, Zora Thoroughman, Doug TI Assessing Functional Needs Sheltering in Pike County, Kentucky: Using a Community Assessment for Public Health Emergency Response SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE needs assessment; disaster planning; emergency preparedness ID SAMPLING METHOD AB Objective: During 2009-2011, Pike County, Kentucky, experienced a series of severe weather events that resulted in property damage, insufficient potable water, and need for temporary shelters. A Community Assessment for Public Health Emergency Response (CASPER) survey was implemented for future planning. CASPER assesses household health status, preparedness level, and anticipated demand for shelters. Methods: We used a 2-stage cluster sampling design to randomly select 210 representative households for in-person interviews. We estimated the proportion of households with children aged 2 years or younger; adults aged 65 years or older; and residents with chronic health conditions, visual impairments, physical limitations, and supplemental oxygen requirements. Results: Of all households surveyed, 8% included children aged 2 years or younger, and 27% included adults aged 65 years or older. The most common chronic health conditions were heart disease (51%), diabetes (28%), lung disease (23%), and asthma (21%). Visual impairments were reported in 29% of households, physical limitations in 24%, and supplemental oxygen use in 12%. Conclusions: Pike County residents should be encouraged to maintain an adequate supply of medications and copies of their prescriptions. Emergency response plans should include transportation for persons with physical limitations; and shelter plans should include sufficient medically trained staff and adequate supplies of infant formula, pharmaceuticals, and supplemental oxygen. (Disaster Med Public Health Preparedness. 2013; 7: 597-602) C1 [Kolwaite, Amy R.; Daley, W. Randolph] Epidem Intelligence Serv, Atlanta, GA USA. [Cadwell, Betsy L.; Fleischauer, Aaron T.; Thoroughman, Doug] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hlady, W. Gary] US Hlth Resources & Serv Adm, Bur Clinician Recruitment & Serv, San Francisco, CA USA. [Simon, Matthew C.] Univ N Carolina, Ctr Publ Hlth Preparedness, North Carolina Inst Publ Hlth, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Kolwaite, Amy R.; Thoroughman, Doug] Kentucky Dept Publ Hlth, Frankfort, KY 40621 USA. [May, Zora] Pike Cty Hlth Dept, Pikeville, KY USA. [Fleischauer, Aaron T.] North Carolina Div Publ Hlth, Raleigh, NC USA. RP Kolwaite, AR (reprint author), Kentucky Dept Publ Hlth, 275 E Main St HS 2GW-C, Frankfort, KY 40621 USA. EM izj9@cdc.gov NR 20 TC 1 Z9 1 U1 3 U2 7 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1935-7893 EI 1938-744X J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD DEC PY 2013 VL 7 IS 6 BP 597 EP 602 DI 10.1017/dmp.2013.110 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AL3XD UT WOS:000339064000011 PM 24444133 ER PT J AU Blanck, HM Collins, J AF Blanck, Heidi M. Collins, Janet TI CDC's Winnable Battles: Improved Nutrition, Physical Activity, and Decreased Obesity SO CHILDHOOD OBESITY LA English DT Editorial Material ID UNITED-STATES; CHILDREN; TRENDS C1 [Blanck, Heidi M.; Collins, Janet] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Blanck, HM (reprint author), Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS F-77, Atlanta, GA 30341 USA. EM hcb3@cdc.gov NR 18 TC 2 Z9 2 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-2168 EI 2153-2176 J9 CHILD OBES JI Child Obes. PD DEC PY 2013 VL 9 IS 6 BP 469 EP 471 DI 10.1089/chi.2013.9506 PG 3 WC Pediatrics SC Pediatrics GA AI5GA UT WOS:000336892200001 PM 24236850 ER PT J AU Raffo, V Bliss, T Shotten, M Sleet, D Blanchard, C AF Raffo, Veronica Bliss, Tony Shotten, Marc Sleet, David Blanchard, Claire TI Case study: The Argentina Road Safety Project: lessons learned for the decade of action for road safety, 2011-2020 SO GLOBAL HEALTH PROMOTION LA English DT Article DE Argentina; guidelines; injury; management; road safety; World Bank projects AB This case study of the Argentina Road Safety Project demonstrates how the application of World Bank road safety project guidelines focused on institution building can accelerate knowledge transfer, scale up investment and improve the focus on results. The case study highlights road safety as a development priority and outlines World Bank initiatives addressing the implementation of the World Report on Road Traffic Injury's recommendations and the subsequent launch of the Decade of Action for Road Safety, from 2011-2020. The case study emphasizes the vital role played by the lead agency in ensuring sustainable road safety improvements and promoting the shift to a Safe System' approach, which necessitated the strengthening of all elements of the road safety management system. It summarizes road safety performance and institutional initiatives in Argentina leading up to the preparation and implementation of the project. We describe the project's development objectives, financing arrangements, specific components and investment staging. Finally, we discuss its innovative features and lessons learned, and present a set of supplementary guidelines, both to assist multilateral development banks and their clients with future road safety initiatives, and to encourage better linkages between the health and transportation sectors supporting them. C1 [Raffo, Veronica; Shotten, Marc] World Bank, Washington, DC 20433 USA. [Bliss, Tony] Monash Univ, Monash Injury Res Inst, Clayton, Vic 3800, Australia. [Sleet, David] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blanchard, Claire] Int Union Hlth Promot & Educ, St Denis, France. RP Raffo, V (reprint author), World Bank, 1818 H St NW, Washington, DC 20433 USA. EM vraffo@worldbank.org NR 24 TC 3 Z9 3 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1757-9759 EI 1757-9767 J9 GLOB HEALTH PROMOT JI Glob. Health Promot. PD DEC PY 2013 VL 20 SU 4 BP 20 EP 36 DI 10.1177/1757975913502690 PG 17 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AE7KO UT WOS:000334176900003 PM 24722740 ER PT J AU Roehler, DR Naumann, RB Mutatina, B Nakitto, M Mwanje, B Brondum, L Blanchard, C Baldwin, GT Dellinger, AM AF Roehler, Douglas R. Naumann, Rebecca B. Mutatina, Boniface Nakitto, Mable Mwanje, Barbara Brondum, Lotte Blanchard, Claire Baldwin, Grant T. Dellinger, Ann M. TI Using baseline and formative evaluation data to inform the Uganda Helmet Vaccine Initiative SO GLOBAL HEALTH PROMOTION LA English DT Article DE health behavior; health promotion; injury prevention; motorcycle ID SAFETY; FATALITIES; VIETNAM AB Motorcycles are an important form of transportation in Uganda, and are involved in more road traffic injuries than any other vehicle. The majority of motorcycles in Uganda are used as motorcycle taxis, better known locally as boda bodas. Research shows that a motorcycle helmet is effective at reducing a rider's risk of death and head injury. As part of the Uganda Helmet Vaccine Initiative (UHVI), researchers collected baseline and formative evaluation data on boda boda operators' helmet attitudes, beliefs, and behaviors to inform UHVI activities. Researchers collected data on motorcycle helmet-related attitudes and beliefs through focus group discussions and structured roadside interviews, and researchers conducted roadside observations to collect data on helmet-wearing behaviors. Of the 12,189 motorcycle operators and passengers observed during roadside observations, 30.8% of drivers and <1% of passengers were wearing helmets. The most commonly reported helmet-wearing barriers from the focus group discussions and structured roadside interviews were: (1) Helmet is uncomfortable', (2) Helmet is too hot', (3) Helmet is too expensive', and (4) Helmet is of low quality'. Researchers incorporated findings from the formative research into the UHVI campaign to increase motorcycle helmet use. Radio messages addressing helmet comfort and cost were widely aired throughout Kampala, Uganda. In addition, campaign staff held nine boda boda operator workshops, covering approximately 900 operators, in which the facilitator addressed barriers and facilitators to helmet use. Each workshop participant received a high-quality tropical motorcycle helmet. UHVI will continue to use a data-driven approach to future campaign activities. C1 [Roehler, Douglas R.; Naumann, Rebecca B.; Baldwin, Grant T.; Dellinger, Ann M.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Atlanta, GA USA. [Roehler, Douglas R.] McNeal Profess Serv, Kennesaw, GA USA. [Mutatina, Boniface; Nakitto, Mable] Injury Control Ctr Uganda, Kampala, Uganda. [Mwanje, Barbara] Global Helmet Vaccine Initiat, Kampala, Uganda. [Brondum, Lotte] Asia Injury Prevent Fdn, Hanoi, Vietnam. [Blanchard, Claire] Int Union Hlth Promot & Educ, St Denis, France. [Roehler, Douglas R.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Naumann, Rebecca B.] Univ N Carolina, Gillings Sch Publ Hlth, Chapel Hill, NC USA. RP Roehler, DR (reprint author), Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. EM droehler@umich.edu NR 27 TC 3 Z9 3 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1757-9759 EI 1757-9767 J9 GLOB HEALTH PROMOT JI Glob. Health Promot. PD DEC PY 2013 VL 20 SU 4 BP 37 EP 44 DI 10.1177/1757975913509657 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AE7KO UT WOS:000334176900004 PM 24722741 ER PT J AU Barboza, CF Monteiro, SMDR Barradas, SC Sarmiento, OL Rios, P Ramirez, A Mahecha, MP Pratt, M AF Finck Barboza, Carolyn Monteiro, Sarojini M. D. R. Barradas, Susana C. Sarmiento, Olga L. Rios, Paola Ramirez, Andrea Mahecha, Maria P. Pratt, Michael TI Physical activity, nutrition and behavior change in Latin America: a systematic review SO GLOBAL HEALTH PROMOTION LA English DT Article DE health behavior; health promotion; physical activity; nutrition ID PROTECTION MOTIVATION THEORY; EVIDENCE-BASED INTERVENTIONS; TRANSTHEORETICAL MODEL; HEALTH-PROMOTION; SELF-EFFICACY; NONCOMMUNICABLE DISEASES; PLANNED BEHAVIOR; PRIMARY-CARE; LIFE-STYLE; LOW-INCOME AB Physical activity (PA) and nutrition are key health behaviors underlying the design and implementation of prevention strategies for non-communicable diseases (NCDs) in Latin America. Nevertheless, research still reports low prevalence of PA and fruit and vegetable consumption throughout the region. This paper aims at reviewing the ways in which models of behavior change theory have been applied in study development and implementation regarding nutrition and PA in Latin America. In August 2011 we conducted a systematic literature review of the behavior change studies that targeted such NCDs risk factors published until then. Out of 4279 surveyed abstracts, only 29 corresponded to articles that met our inclusion criteria. Twenty-six articles reported the application of behavior change theory, with the trans-theoretical model (n = 12) being the most frequently used. Other theories and models included the socio-ecological model (n = 4), cognitive theory (n = 3), social cognitive theory (n = 2) and theories related to health education and counseling (n = 5). Based on this review, we recommend that the application of behavior change theory be explicitly reported in Latin American peer-reviewed articles, and that outcome evaluations include behavior change constructs so as to better assess their contribution to the effectiveness of nutrition and PA interventions in the region. Furthermore, we state the need for a better understanding of the behavior change mechanisms that may be specific to the Latin American context. C1 [Finck Barboza, Carolyn; Barradas, Susana C.] Univ Los Andes, Dept Psychol, Bogota, Colombia. [Monteiro, Sarojini M. D. R.] Curtin Univ, Sch Publ Hlth, Perth, WA 6845, Australia. [Sarmiento, Olga L.; Rios, Paola; Ramirez, Andrea; Mahecha, Maria P.; Pratt, Michael] Univ Los Andes, Sch Med, Bogota, Colombia. [Pratt, Michael] Ctr Dis Control & Prevent CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Barboza, CF (reprint author), Univ Los Andes, Dept Psychol, Cra 1 18A-12, Bogota, Colombia. EM cfinck@uniandes.edu.co OI Sarmiento, Olga/0000-0002-9190-3568 NR 91 TC 6 Z9 6 U1 8 U2 19 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1757-9759 EI 1757-9767 J9 GLOB HEALTH PROMOT JI Glob. Health Promot. PD DEC PY 2013 VL 20 SU 4 BP 65 EP 81 DI 10.1177/1757975913502240 PG 17 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AE7KO UT WOS:000334176900007 ER PT J AU McQueen, D Pratt, M Blanchard, C AF McQueen, David Pratt, Michael Blanchard, Claire TI Commentary on a meeting entitled 'Building global capacity for non-communicable diseases (NCD) prevention: Defining direction and roles' SO GLOBAL HEALTH PROMOTION LA English DT Editorial Material DE chronic disease; effectiveness; non-communicable disease; capacity building AB This Commentary summarizes the key points that arose during a three-day meeting held in Atlanta in July 2012 on Building Global Capacity for NCD Prevention. A wide spectrum of participants representing many sectors of global health, including ministries of health from several low and middle-income countries (LMICs), governmental institutions, non-governmental organizations, national disease associations, academia, and global and regional institutions participated. Presentations and group discussions led to agreement on a number of actions that should be taken to increase capacity for coping with NCDs in LMICs. Key areas of discussion were on the role of research, workforce development, resources, and governance. While there was considerable agreement on what should be done, the workshop participants had difficulty in prioritizing these activities. This led to an agreement by the gathered participants that a follow-up Delphi study be conducted to help with prioritization. C1 [McQueen, David] CDC, Atlanta, GA 30333 USA. [Pratt, Michael] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Blanchard, Claire] Int Union Hlth Promot & Educ, St Denis, France. RP McQueen, D (reprint author), 2418 Midvale Ct, Tucker, GA 30084 USA. EM davidmcqueen07@gmail.com NR 5 TC 3 Z9 3 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1757-9759 EI 1757-9767 J9 GLOB HEALTH PROMOT JI Glob. Health Promot. PD DEC PY 2013 VL 20 SU 4 BP 93 EP 96 DI 10.1177/1757975913509656 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AE7KO UT WOS:000334176900010 PM 24722747 ER PT J AU Kirkcaldy, RD Kidd, S Weinstock, HS Papp, JR Bolan, GA AF Kirkcaldy, Robert D. Kidd, Sarah Weinstock, Hillard S. Papp, John R. Bolan, Gail A. TI Trends in antimicrobial resistance in Neisseria gonorrhoeae in the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006-June 2012 SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article DE Antimicrobial Resistance; Neisseria Gonorrhoea; Surveillance ID SEXUALLY-TRANSMITTED-DISEASES; PUBLIC-HEALTH LABORATORIES; TREATMENT-GUIDELINES; RISK-FACTORS; NO LONGER; INFECTIONS; SUSCEPTIBILITY; CEPHALOSPORIN; UPDATE AB Background Neisseria gonorrhoeae has progressively developed resistance to sulfonamides, penicillin, tetracycline and fluoroquinolones, and gonococcal susceptibility to cephalosporins has been declining worldwide. Methods We described trends in gonococcal antimicrobial susceptibility in the USA from January 2006 through June 2012. Susceptibility data for cefixime, ceftriaxone, azithromycin, penicillin, tetracycline and ciprofloxacin were obtained from the Gonococcal Isolate Surveillance Project (GISP), a sentinel surveillance system that monitors antimicrobial susceptibility in urethral gonococcal isolates collected from symptomatic men at 25-30 sexually transmitted disease clinics throughout the USA. Results The percentage of isolates with elevated cefixime minimum inhibitory concentrations (MICs) (>= 0.25 mu g/mL) increased from 0.1% in 2006 to 1.4% in 2010-2011 and was 1.1% in the first 6 months of 2012. The percentage with elevated ceftriaxone MICs (>= 0.125 mu g/mL) increased from 0.1% in 2006 to 0.3%-0.4% during 2009 through the first 6 months of 2012. There were no temporal trends in the prevalence of elevated azithromycin MICs (>= 2 mu g/mL) (0.2%-0.5%). The prevalence of resistance remained high for penicillin (11.2%-13.2%), tetracycline (16.7%-22.8%) and ciprofloxacin (9.6%-14.8%). Conclusions The proportion of gonococcal isolates with elevated cephalosporin MICs increased from 2006 to 2010, but plateaued during 2011 and the first 6 months of 2012. Resistance to previously recommended antimicrobials has persisted. As the number of antimicrobials available for gonorrhoea treatment dwindles, surveillance systems such as GISP will be critical to detect emerging resistance trends and guide treatment decisions. C1 [Kirkcaldy, Robert D.; Kidd, Sarah; Weinstock, Hillard S.; Papp, John R.; Bolan, Gail A.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Kirkcaldy, RD (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM rkirkcaldy@cdc.gov FU Centers for Disease Control and Prevention FX Centers for Disease Control and Prevention. NR 33 TC 27 Z9 28 U1 0 U2 5 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 EI 1472-3263 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD DEC PY 2013 VL 89 IS 4 SU 4 BP 5 EP 10 DI 10.1136/sextrans-2013-051162 PG 6 WC Infectious Diseases SC Infectious Diseases GA AE3VS UT WOS:000333907100003 PM 24243881 ER PT J AU Islam, A Mikolon, A Mikoleit, M Ahmed, D Khan, SU Sharker, MAY Hossain, MJ Islam, A Epstein, JH Zeidner, N Luby, SP AF Islam, Ausraful Mikolon, Andrea Mikoleit, Matthew Ahmed, Dilruba Khan, Salah Udddin Sharker, M. A. Yushuf Hossain, M. Jahangir Islam, Ariful Epstein, Jonathan H. Zeidner, Nord Luby, Stephen P. TI Isolation of Salmonella Virchow from a Fruit Bat (Pteropus giganteus) SO ECOHEALTH LA English DT Article DE fruit bats; Pteropus giganteus; Salmonella Typhi; Salmonella Virchow; Bangladesh ID TYPHOID-FEVER; BANGLADESH; DHAKA AB Detection of zoonotic pathogens carried by bats is important both for understanding disease ecology and for developing preventive measures. Pteropus fruit bats have been identified as potential carriers of Salmonella enterica serotype Typhi. A cross-sectional study was conducted to determine the prevalence of Salmonella Typhi and other Salmonella serotypes in Pteropus giganteus fruit bats in Bangladesh. Rectal swabs were collected from 302 bats and cultured for Salmonella species. The bats were trapped in three districts (Faridpur, Rajbari, and Cox's Bazar). Salmonella Typhi was not found but one juvenile female bat from Faridpur district was positive for Salmonella Virchow. Close associations between frugivorous bats, humans, and livestock in rural Bangladesh make it likely that the bat was infected by consuming contaminated water. C1 [Islam, Ausraful; Mikolon, Andrea; Ahmed, Dilruba; Khan, Salah Udddin; Sharker, M. A. Yushuf; Hossain, M. Jahangir; Zeidner, Nord; Luby, Stephen P.] ICDDR B, Dhaka 1212, Bangladesh. [Mikoleit, Matthew] Ctr Dis Control & Prevent CDC, Enter Dis Lab Branch, Atlanta, GA USA. [Islam, Ariful; Epstein, Jonathan H.] EcoHealth Alliance, New York, NY 10001 USA. [Epstein, Jonathan H.] Univ Kingston, Sch Life Sci, Kingston Upon Thames KT1 2EE, Surrey, England. RP Islam, A (reprint author), ICDDR B, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka 1212, Bangladesh. EM islam_ausraf@icddrb.org OI Luby, Stephen/0000-0001-5385-899X FU National Institute of Health (NIH) through EchoHealth Alliance [07-015-0712-52200] FX This research study was funded by the National Institute of Health (NIH) through EchoHealth Alliance, Grant Number 07-015-0712-52200. ICDDR,B acknowledges with gratitude the commitment of NIH to its research efforts. ICDDR,B is grateful to CDC for their laboratory support for the study. NR 22 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-9202 EI 1612-9210 J9 ECOHEALTH JI EcoHealth PD DEC PY 2013 VL 10 IS 4 BP 348 EP 351 DI 10.1007/s10393-013-0866-y PG 4 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AC2VT UT WOS:000332375100005 PM 24136382 ER PT J AU Parra, DC Hoehner, CM Hallal, PC Reis, RS Simoes, EJ Malta, DC Pratt, M Brownson, RC AF Parra, Diana C. Hoehner, Christine M. Hallal, Pedro C. Reis, Rodrigo S. Simoes, Eduardo J. Malta, Deborah C. Pratt, Michael Brownson, Ross C. TI Scaling up of physical activity interventions in Brazil: how partnerships and research evidence contributed to policy action SO GLOBAL HEALTH PROMOTION LA English DT Article DE physical activity; policy; practice; program planning; management; collaboration; partnership; communicable disease ID LATIN-AMERICA; CHALLENGES; PROMOTION; PROGRAM; WORLD AB The global health burden due to physical inactivity is enormous and growing. There is a need to consider new ways of generating evidence and to identify the role of government in promoting physical activity at the population level. In this paper, we summarize key findings from a large-scale cross-national collaboration to understand physical activity promotion in Brazil. We describe the main aspects of the partnership of Project GUIA (Guide for Useful Interventions for Activity in Brazil and Latin America) that sustained the collaborative effort for eight years and describe how the evidence gathered from the collaboration triggered political action in Brazil to scale up a physical activity intervention at the national level. Project GUIA is a cross-national multidisciplinary research partnership designed to understand and evaluate current efforts for physical activity promotion at the community level in Latin America. This example of scaling up is unprecedented for promoting health in the region and is an example that must be followed and evaluated. C1 [Parra, Diana C.] Washington Univ, Prevent Res Ctr, St Louis, MO 63130 USA. [Hoehner, Christine M.; Brownson, Ross C.] Washington Univ, Div Publ Hlth Sci, St Louis, MO USA. [Hoehner, Christine M.; Brownson, Ross C.] Alvin J Siteman Canc Ctr, Sch Med St Louis, St Louis, MO USA. [Hallal, Pedro C.] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil. [Reis, Rodrigo S.] Pontificia Univ Catolica Parana, Dept Phys Educ, Curitiba, Parana, Brazil. [Reis, Rodrigo S.] Univ Fed Parana, Dept Phys Educ, BR-80060000 Curitiba, Parana, Brazil. [Simoes, Eduardo J.] Univ Missouri, Sch Med, Dept Hlth Management & Informat, Columbia, MO USA. [Malta, Deborah C.] Minist Hlth Brazil, Div Situat Anal & Prevent Nontransmissible Dis, Brasilia, DF, Brazil. [Pratt, Michael] Ctr Dis Control & Prevent, Off Global Hlth, Atlanta, GA USA. RP Parra, DC (reprint author), Washington Univ, Prevent Res Ctr, 8150 Whitburn Dr 2 W, St Louis, MO 63130 USA. EM dianacpp79@yahoo.com RI Hallal, Pedro/A-3249-2011; Parra, Diana/B-7761-2015; Reis, Rodrigo/F-7447-2012; Malta, Deborah/H-7880-2012 OI Hallal, Pedro/0000-0003-1470-6461; Parra, Diana/0000-0002-9797-6231; Reis, Rodrigo/0000-0002-9872-9865; Malta, Deborah/0000-0002-8214-5734 FU NCCDPHP CDC HHS [U48 DP001903]; NIDDK NIH HHS [P30 DK092950]; Wellcome Trust [095582] NR 43 TC 10 Z9 11 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1757-9759 EI 1757-9767 J9 GLOB HEALTH PROMOT JI Glob. Health Promot. PD DEC PY 2013 VL 20 IS 4 BP 5 EP 12 DI 10.1177/1757975913502368 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AA6GV UT WOS:000331197700002 PM 24323944 ER PT J AU Bachani, AM Branching, C Ear, C Roehler, DR Parker, EM Tum, S Ballesteros, MF Hyder, AA AF Bachani, Abdulgafoor M. Branching, Casey Ear, Chariya Roehler, Douglas R. Parker, Erin M. Tum, Sotheary Ballesteros, Michael F. Hyder, Adnan A. TI Trends in prevalence, knowledge, attitudes, and practices of helmet use in Cambodia: results from a two year study SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Motorcycle; Head injuries; Cambodia; Road safety; Asia ID HEAD-INJURIES; MOTORCYCLISTS; COUNTRIES; RIDERS; MODEL; LAWS AB Introduction: Road traffic injuries (RTIs) are a major cause of both morbidity and mortality globally. Relative to countries with similar economic patterns both within and outside of South-East Asia, Cambodia's road traffic fatality rate is high, with motorcyclists accounting for more than half of all fatalities as a result of head injuries. Despite the initiation of national motorcycle helmet legislation for Cambodian drivers in 2009, helmet use among both drivers and passengers remains low. Methods: This study adopted a two-pronged approach to assess the current status of and knowledge, attitudes, and practices (KAPs) towards helmet use among drivers and passengers in five provinces in Cambodia. The objective was to better understand helmet use over a two year period since the introduction of the 2009 legislation. Researchers conducted both (1) direct observation of daytime and nighttime helmet use (January 2011-January 2013) and (2) roadside KAP interviews with motorcyclists (November 2010-November 2012). Results: The observed helmet rate across all study sites was 33% during nighttime and 48% during daytime, with proportions up to ten times higher among drivers compared with passengers. Self-reported helmet use was higher than observed use. Within the past 30 days, 60% of respondents reported that they "always" wore a helmet when they were drivers while only 24% reported they "always" wore a helmet as a passenger. Reported barriers for use among drivers included: "driving route", "forgetfulness", and "inconvenience/discomfort." Conclusion: Despite awareness of the protective value of helmets, motorcycle helmet use rates remain low in Cambodia. Many misconceptions remain in Cambodia regarding helmet use, including that they are unnecessary for short distance or at low speeds. These serve as an important barrier to helmet use, which, if dispelled and coupled with visible and regular enforcement, may significantly reduce the number of motorcycle-related injuries and fatalities. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Bachani, Abdulgafoor M.; Branching, Casey; Hyder, Adnan A.] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Int Injury Res Unit, Baltimore, MD USA. [Ear, Chariya; Tum, Sotheary] Handicap Int Belgium, Phnom Penh, Cambodia. [Roehler, Douglas R.; Parker, Erin M.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Ballesteros, Michael F.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USA. RP Bachani, AM (reprint author), 615 N Wolfe St,Suite E-8132, Baltimore, MD 21205 USA. EM abachani@jhsph.edu FU Bloomberg Philanthropies FX This work was conducted as part of the Global Road Safety Programmes, funded by Bloomberg Philanthropies. Additional support for some of the data collection provided by the Centers for Disease Control and Prevention and the Asia Injury Prevention Foundation. NR 25 TC 6 Z9 7 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 EI 1879-0267 J9 INJURY JI Injury-Int. J. Care Inj. PD DEC PY 2013 VL 44 SU 4 BP S31 EP S37 PG 7 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA AA9II UT WOS:000331406600007 PM 24377776 ER PT J AU Schilling, K Person, B Faith, SH Otieno, R Quick, R AF Schilling, Katharine Person, Bobbie Faith, Sitnah H. Otieno, Ronald Quick, Robert TI The Challenge of Promoting Interventions to Prevent Disease in Impoverished Populations in Rural Western Kenya SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID WATER; COMMUNITY; DIARRHEA; ENOUGH AB Poverty is a critical social determinant of health. A particular approach toward mitigating inequitable access to health services in Kenya has been through a community-based distribution program implemented by the Safe Water and AIDS Project (SWAP) that has achieved modest uptake of public health interventions. To explore reasons for modest uptake, we asked program participants about child health problems, daily tasks, household expenditures, and services needed by their communities. Respondents identified child health problems consistent with health data and reported daily tasks, expenses, and needed services that were more related to basic needs of life other than health. These findings highlight the challenges of implementing potentially self-sustaining preventive interventions at scale in poor populations in the developing world. C1 [Schilling, Katharine; Quick, Robert] US Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Waterborne Dis Prevent Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Person, Bobbie] US Ctr Dis Control & Prevent, Off Director, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Faith, Sitnah H.; Otieno, Ronald] Safe Water & AIDS Project, Kisumu, Kenya. RP Schilling, K (reprint author), Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, 1600 Clifton Rd NE,MS C09, Atlanta, GA 30329 USA. EM kschilling@cdc.gov RI Mashamba-Thompson, Tivani /B-6087-2014 FU Centers for Disease Control and Prevention (CDC); United States Agency for International Development FX Financial support for this study was provided by the Centers for Disease Control and Prevention (CDC) and the United States Agency for International Development. NR 20 TC 2 Z9 2 U1 0 U2 6 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2013 VL 103 IS 12 BP 2131 EP 2135 DI 10.2105/AJPH.2013.301459 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AA4CV UT WOS:000331043200020 PM 24188638 ER PT J AU Sutton, MY Lanier, YA Willis, LA Castellanos, T Dominguez, K Fitzpatrick, L Miller, KS AF Sutton, Madeline Y. Lanier, Yzette A. Willis, Leigh A. Castellanos, Ted Dominguez, Ken Fitzpatrick, Lisa Miller, Kim S. TI Strengthening the Network of Mentored, Underrepresented Minority Scientists and Leaders to Reduce HIV-Related Health Disparities SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID PROGRAM; INVESTIGATORS; COMMUNITIES; PREVENTION; BARRIERS; BLACK; CARE; HIV/AIDS; MODEL; GAPS AB Objectives. We reviewed data for the Minority HIV/AIDS Research Initiative (MARI), which was established in 2003 to support underrepresented minority scientists performing HIV prevention research in highly affected communities. Methods. MARI was established at the Centers for Disease Prevention and Control as a program of competitively awarded, mentored grants for early career researchers conducting HIV prevention research in highly affected racial/ethnic and sexual minority communities. We have described progress from 2003 to 2013. Results. To date, MARI has mentored 27 scientist leaders using low-cost strategies to enhance the development of effective HIV prevention interventions. These scientists have (1) developed research programs in disproportionately affected communities of color, (2) produced first-authored peer-reviewed scientific and programmatic products (including articles and community-level interventions), and (3) obtained larger, subsequent funding awards for research and programmatic work related to HIV prevention and health disparities work. Conclusions. The MARI program demonstrates how to effectively engage minority scientists to conduct HIV prevention research and reduce racial/ethnic investigator disparities and serves as a model for programs to reduce disparities in other public health areas in which communities of color are disproportionately affected. C1 [Sutton, Madeline Y.; Lanier, Yzette A.; Willis, Leigh A.; Castellanos, Ted; Dominguez, Ken; Fitzpatrick, Lisa; Miller, Kim S.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Sutton, MY (reprint author), DHAP NCHHSTP CDC, 1600 Clifton Rd NE,MS E-45, Atlanta, GA 30333 USA. EM zxa3@cdc.gov FU Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention [PS07-003, PS11-003] FX The Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention funded the Minority HIV/AIDS Research Initiative (cooperative agreements PS07-003 and PS11-003). NR 41 TC 9 Z9 9 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2013 VL 103 IS 12 BP 2207 EP 2214 DI 10.2105/AJPH.2013.301345 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AA4CV UT WOS:000331043200034 PM 24134360 ER PT J AU Samoff, E DiBiase, L Fangman, MT Fleischauer, AT Waller, AE MacDonald, PDM AF Samoff, Erika DiBiase, Lauren Fangman, Mary T. Fleischauer, Aaron T. Waller, Anna E. MacDonald, Pia D. M. TI We Can Have It All: Improved Surveillance Outcomes and Decreased Personnel Costs Associated With Electronic Reportable Disease Surveillance, North Carolina, 2010 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID STATE HEALTH DEPARTMENTS; UNITED-STATES; EPIDEMIOLOGY CAPACITY; LOCAL HEALTH; SYSTEMS AB Objectives. We assessed the timeliness, accuracy, and cost of a new electronic disease surveillance system at the local health department level. We describe practices associated with lower cost and better surveillance timeliness and accuracy. Methods. Interviews conducted May through August 2010 with local health department (LHD) staff at a simple random sample of 30 of 100 North Carolina counties provided information on surveillance practices and costs; we used surveillance system data to calculate timeliness and accuracy. We identified LHDs with best timeliness and accuracy and used these categories to compare surveillance practices and costs. Results. Local health departments in the top tertiles for surveillance timeliness and accuracy had a lower cost per case reported than LHDs with lower timeliness and accuracy ($71 and $124 per case reported, respectively; P = .03). Best surveillance practices fell into 2 domains: efficient use of the electronic surveillance system and use of surveillance data for local evaluation and program management. Conclusions. Timely and accurate surveillance can be achieved in the setting of restricted funding experienced by many LHDs. Adopting best surveillance practices may improve both efficiency and public health outcomes. C1 [Samoff, Erika; DiBiase, Lauren; Fangman, Mary T.; MacDonald, Pia D. M.] Univ N Carolina, Inst Publ Hlth, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Fleischauer, Aaron T.] Ctr Dis Control & Prevent, Raleigh, NC USA. [Fleischauer, Aaron T.] North Carolina Div Publ Hlth, Raleigh, NC USA. [Waller, Anna E.] Univ N Carolina, Dept Emergency Med, Carolina Ctr Hlth Informat, Chapel Hill, NC USA. RP Samoff, E (reprint author), Durham Cty Dept Publ Hlth, 414 E Main St, Durham, NC 27701 USA. EM esamoff@dconc.gov FU Centers for Disease Control and Prevention (CDC) [1PO1 TP 000296] FX This research was supported by the Centers for Disease Control and Prevention (CDC; grant 1PO1 TP 000296). NR 20 TC 0 Z9 0 U1 1 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2013 VL 103 IS 12 BP 2292 EP 2297 DI 10.2105/AJPH.2013.301353 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AA4CV UT WOS:000331043200045 PM 24134385 ER PT J AU Dhara, VR Schramm, PJ Luber, G AF Dhara, V. Ramana Schramm, Paul J. Luber, George TI Climate change & infectious diseases in India: Implications for health care providers SO INDIAN JOURNAL OF MEDICAL RESEARCH LA English DT Review DE Climate change; human health; India; vector-borne disease; water-borne disease ID FLOODS; BANGLADESH; IMPACTS; MALARIA; LEPTOSPIROSIS; ADAPTATION; OUTBREAK AB Climate change has the potential to influence the earth's biological systems, however, its effects on human health are not well defined. Developing nations with limited resources are expected to face a host of health effects due to climate change, including vector-borne and water-borne diseases such as malaria, cholera, and dengue. This article reviews common and prevalent infectious diseases in India, their links to climate change, and how health care providers might discuss preventive health care strategies with their patients. C1 [Dhara, V. Ramana] Ctr Dis Control & Prevent, Environm Safety & Hlth Compliance Off, Atlanta, GA 30341 USA. [Schramm, Paul J.; Luber, George] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Climate & Hlth Program, Atlanta, GA 30341 USA. RP Schramm, PJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy,Bldg 106, Atlanta, GA 30341 USA. EM PSchramm@cdc.gov NR 39 TC 5 Z9 7 U1 4 U2 15 PU INDIAN COUNCIL MEDICAL RES PI NEW DELHI PA PO BOX 4911 ANSARI NAGAR, NEW DELHI 110029, INDIA SN 0971-5916 J9 INDIAN J MED RES JI Indian J. Med. Res. PD DEC PY 2013 VL 138 BP 847 EP 852 PG 6 WC Immunology; Medicine, General & Internal; Medicine, Research & Experimental SC Immunology; General & Internal Medicine; Research & Experimental Medicine GA AA1TV UT WOS:000330879500008 PM 24521625 ER PT J AU Purakayastha, DR Gupta, V Broor, S Sullender, W Fowler, K Widdowson, MA Lal, RB Krishnan, A AF Purakayastha, Debjani Ram Gupta, Vivek Broor, Shobha Sullender, Wayne Fowler, Karen Widdowson, Marc-Alain Lal, Renu B. Krishnan, Anand TI Clinical differences between influenza A (H1N1) pdm09 & influenza B infections identified through active community surveillance in north India SO INDIAN JOURNAL OF MEDICAL RESEARCH LA English DT Article DE Diagnosis; influenza A; influenza B; H1N1 subtype; respiratory tract infections; signs and symptoms ID SEASONAL INFLUENZA; DESIGN AB Background & objectives: Most studies on the clinical presentation with influenza viruses have been conducted in outpatient or inpatient medical facilities with only a few studies in community settings. Clinical differences between influenza A (H1N1) pdm 09 and influenza B virus infections have importance for community-based public health surveillance. An active community surveillance at the time of emergence of pandemic influenza provided us with an opportunity to compare the clinical features among patients infected with influenza A (H1N1) pdm09 virus and those with influenza B virus co-circulating in an active community-based weekly surveillance in three villages in Faridabad, Haryana, north India. Methods: Active surveillance for febrile acute respiratory infection (FARI) was carried out in a rural community (n=16,182) in the context of an inactivated trivalent influenza vaccine trial (among children <11 yr). Individuals with FARI were assessed clinically by nurses and respiratory samples collected and tested for influenza viruses by real time RT-PCR from November 2009 to August 2010. Clinical symptoms of patients with influenza A (H1N1) pdm 09 and influenza B infection were compared. Results: Of the 4796 samples tested, 822 (17%) were positive for influenza virus. Of these, 443 (54%) were influenza A (H1N1) pdm09, 373 (45%) were influenza B and six were other subtypes/mixed infections. The mean age was lower for patients with influenza B (16.4 yr) than influenza A (H1N1) pdm09 infection (18.7 yr; P=0.04). Among children aged 5-18 yr, chills/rigours (OR 4.0; CI 2.2, 7.4), sore throat (OR 6.8; CI 2.3, 27.3) and headache (OR2.0; CI 1.3, 3.3) were more common in influenza A (H1N1) pdm09 infection than in influenza B cases. Chills/rigours (OR 2.4; CI 1.4, 4.0) and headache (OR 1.7; CI 1.0, 2.7) were associated with influenza A (H1N1) pdm09 infection in those >18 yr. No significant differences were seen in children <5 yr. Conclusion: Our findings show that the differences in the clinical presentation of influenza A(H1N1) pdm09 and influenza B infections are not likely to be of clinical or public health significance. C1 [Purakayastha, Debjani Ram; Broor, Shobha; Krishnan, Anand] All India Inst Med Sci, Ctr Community Med, Dept Microbiol, New Delhi 110029, India. [Gupta, Vivek] InCLEN Trust Int, New Delhi, India. [Sullender, Wayne; Fowler, Karen] Univ Alabama Birmingham, Dept Paediat, Birmingham, AL USA. [Widdowson, Marc-Alain; Lal, Renu B.] US Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Krishnan, A (reprint author), All India Inst Med Sci, Ctr Community Med, New Delhi 110029, India. EM anand.drk@gmail.com OI Krishnan, Anand/0000-0002-9173-7811 FU Centers for Disease Control and Prevention, Atlanta, USA [U01IP000177] FX Authors thank the residents of the study villages, the field and laboratory staff for their commitment, and the CDC Influenza Division personnel for their constructive comments during the pre-submission peer-review process. Anthony Mounts and Joshua Mott participated in initial planning for this study. The study was supported by cooperative agreements U01IP000177 from the Centers for Disease Control and Prevention, Atlanta, USA. NR 31 TC 2 Z9 2 U1 0 U2 4 PU INDIAN COUNCIL MEDICAL RES PI NEW DELHI PA PO BOX 4911 ANSARI NAGAR, NEW DELHI 110029, INDIA SN 0971-5916 J9 INDIAN J MED RES JI Indian J. Med. Res. PD DEC PY 2013 VL 138 BP 962 EP 968 PG 7 WC Immunology; Medicine, General & Internal; Medicine, Research & Experimental SC Immunology; General & Internal Medicine; Research & Experimental Medicine GA AA1TV UT WOS:000330879500026 PM 24521643 ER PT J AU Khan, UH Mir, MA Ahmad, F Mir, MH Bali, NK Lal, RB Broor, SS Koul, PA AF Khan, Umar H. Mir, Muneer A. Ahmad, Feroze Mir, M. Hussain Bali, Nargis K. Lal, Renu B. Broor, Shobha S. Koul, Parvaiz A. TI An outbreak of influenza B in an isolated nomadic community in Jammu & Kashmir, India SO INDIAN JOURNAL OF MEDICAL RESEARCH LA English DT Article DE Epidemiology; influenza B; nomads; outbreak AB Background & objectives: Community outbreaks of disease amongst nomadic populations generally remain undocumented. Following a reported increase in acute respiratory tract infections (ARI) in May 2011 in a nomadic population of Sangerwini in Jammu & Kashmir, India, we examined the patients with ARI symptoms and their nasal swabs were tested for influenza virus. Methods: Patients with ARI (n=526) were screened from May 14 to 23, 2011 and nasopharyngeal swabs collected from 84 with Influenza like illness (ILI) for bacterial cultures and influenza virus testing. Samples were tested for influenza A and influenza B by real time (RT)-PCR. Results: Twelve (14.3%) of the 84 patients tested positive for influenza B, compared to only one (0.9%) of 108 patients with ILI in a parallel survey performed in Srinagar during the same period, suggesting a localized outbreak in the isolated nomadic community. All presented with respiratory symptoms of less than seven days. Familial clustering was seen in 40 per cent (25% of influenza B positives). Average daytime temperatures ranged from 15-16 degrees C compared to 22 degrees C in Srinagar. Four patients developed pneumonia whereas others ran a mild course with a total recovery with oseltamivir and symptomatic therapy. Interpretation & conclusion: Our report of confirmed influenza B in this underprivileged nomadic population argues for routine surveillance with efforts to improve vaccination and infection control practices. C1 [Khan, Umar H.; Ahmad, Feroze; Mir, M. Hussain; Koul, Parvaiz A.] Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar 190011, Jammu & Kashmir, India. [Mir, Muneer A.; Bali, Nargis K.] Sherikashmir Inst Med Sci, Dept Clin Microbiol, Srinagar 190011, Jammu & Kashmir, India. [Broor, Shobha S.] All India Inst Med Sci, Dept Virol, New Delhi, India. [Lal, Renu B.] Ctr Dis Control & Prevent CDC, Influenza Div, Atlanta, GA USA. RP Koul, PA (reprint author), Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar 190011, Jammu & Kashmir, India. EM parvaizk@gmail.com FU Centre for Disease Control and Prevention, Influenza Division, Atlanta, GA, USA FX The study was funded by the Centre for Disease Control and Prevention, Influenza Division, Atlanta, GA, USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU INDIAN COUNCIL MEDICAL RES PI NEW DELHI PA PO BOX 4911 ANSARI NAGAR, NEW DELHI 110029, INDIA SN 0971-5916 J9 INDIAN J MED RES JI Indian J. Med. Res. PD DEC PY 2013 VL 138 BP 1012 EP 1015 PG 4 WC Immunology; Medicine, General & Internal; Medicine, Research & Experimental SC Immunology; General & Internal Medicine; Research & Experimental Medicine GA AA1TV UT WOS:000330879500032 PM 24521649 ER PT J AU Caillouet, KA Robertson, CW Wheeler, DC Komar, N Bulluck, LP AF Caillouet, Kevin A. Robertson, Charles W. Wheeler, David C. Komar, Nicholas Bulluck, Lesley P. TI Vector Contact Rates on Eastern Bluebird Nestlings Do Not Indicate West Nile Virus Transmission in Henrico County, Virginia, USA SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE host-seeking rate; nestling; nest mosquito trap; arbovirus; West Nile virus ID EXPERIMENTAL-INFECTION; FEEDING-BEHAVIOR; BIRDS; AMPLIFICATION; COLORADO; DOMESTICUS; ANTIBODIES; MOSQUITOS; GEORGIA; FLORIDA AB Sensitive indicators of spatial and temporal variation in vector-host contact rates are critical to understanding the transmission and eventual prevention of arboviruses such as West Nile virus (WNV). Monitoring vector contact rates on particularly susceptible and perhaps more exposed avian nestlings may provide an advanced indication of local WNV amplification. To test this hypothesis we monitored WNV infection and vector contact rates among nestlings occupying nest boxes (primarily Eastern bluebirds; Sialia sialis, Turdidae) across Henrico County, Virginia, USA, from May to August 2012. Observed host-seeking rates were temporally variable and associated with absolute vector and host abundances. Despite substantial effort to monitor WNV among nestlings and mosquitoes, we did not detect the presence of WNV in these populations. Generally low vector-nestling host contact rates combined with the negative WNV infection data suggest that monitoring transmission parameters among nestling Eastern bluebirds in Henrico County, Virginia, USA may not be a sensitive indicator of WNV activity. C1 [Caillouet, Kevin A.] St Tammany Parish Mosquito Abatement Dist, Slidell, LA 70460 USA. [Caillouet, Kevin A.; Robertson, Charles W.; Bulluck, Lesley P.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Wheeler, David C.] Virginia Commonwealth Univ, Dept Biostat, Richmond, VA 23219 USA. [Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP Caillouet, KA (reprint author), St Tammany Parish Mosquito Abatement Dist, 62512 Airport Rd Bldg 23, Slidell, LA 70460 USA. EM caillouet@stpmad.org; robertsoncw@vcu.edu; dcwheeler@vcu.edu; nkomar@cdc.gov; lpbulluck@vcu.edu FU AD Williams' Fund of the Virginia Commonwealth University (VCU); VCU CTSA from the National Center for Research Resources [UL1RR031990] FX The authors thank Randy Buchanan, Lane Carr, Jennifer Welch and the seasonal staff at the Henrico County Standing Water Initiative for the use of their mosquito surveillance network data. Thanks to Nick Panella for his assistance with preparing specimens for testing. Thanks also to James Cox for helping with nest box construction. Eric Krause assisted with nest box monitoring. We are grateful to the public and private land owners of Henrico County who granted us site access. Bird banding was conducted under USGS Banding Permit #22751 and Virginia Department of Game and Inland Fisheries permit #041077. Bird handling was approved by the Virginia Commonwealth University Animal Care and Use Committee (IACUC Protocol #AM10230). Project support funds were provided by the AD Williams' Fund of the Virginia Commonwealth University (VCU) and the VCU CTSA (UL1RR031990 from the National Center for Research Resources). NR 35 TC 1 Z9 1 U1 0 U2 6 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD DEC PY 2013 VL 10 IS 12 BP 6366 EP 6379 DI 10.3390/ijerph10126366 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 296XV UT WOS:000330219600010 PM 24287858 ER PT J AU Holmes, B Steigerwalt, AG Nicholson, AC AF Holmes, B. Steigerwalt, A. G. Nicholson, A. C. TI DNA-DNA hybridization study of strains of Chryseobacterium, Elizabethkingia and Empedobacter and of other usually indole-producing non-fermenters of CDC groups Ilc, Ile, Ilh and Ili, mostly from human clinical sources, and proposals of Chryseobacterium bernardetii sp nov., Chryseobacterium carnis sp nov., Chryseobacterium lactis sp nov., Chryseobacterium nakagawai sp nov and Chryseobacterium taklimakanense comb. nov. SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID FLAVOBACTERIUM-MENINGOSEPTICUM; GENUS CHRYSEOBACTERIUM; SEJONGIA-MARINA; CLASSIFICATION; HETEROGENEITY; HAIFENSE; BREVE AB The taxonomic classification of 182 phenotypically similar isolates was evaluated using DNA-DNA hybridization and 16S rRNA gene sequence analysis. These bacterial isolates were mainly derived from clinical sources; all were Gram-negative non-fermenters and most were indole-producing. Phenotypically, they resembled species from the genera Chryseobacterium, Elizabethkingia or Empedobacter or belonged to CDC groups Ilc, Ile, Ilh and Ili. Based on these analyses, four novel species are described: Chryseobacterium bernardetii sp. nov. (type strain NCTC 13530(T)=CCUG 60564(T)=CDC G229(T)), Chryseobacterium carnis sp. nov. (type strain NCTC 13525(T)=CCUG 60559(T)=CDC G81(T)), Chryseobacterium lactis sp. nov. (type strain NCTC 11390(T)=CCUG 60566(T)=CDC KC1864(T)) and Chryseobacterium nakagawai sp. nov. (type strain NCTC 13529(T)=CCUG 60563(T)=CDC G41(T)). The new combination Chryseobacterium taklimakanense comb. nov. (type strain NCTC 13490(T)=X-65(T)=CCTCC AB 208154(T)=NRRL B-51322(T)) is also proposed to accommodate the reclassified Planobacterium taklimakanense. C1 [Holmes, B.] Natl Collect Type Cultures, Hlth Protect Agcy, London NW9 5EQ, England. [Steigerwalt, A. G.; Nicholson, A. C.] Ctr Dis Control & Prevent, Special Bacteriol Reference Lab, Atlanta, GA 30333 USA. RP Nicholson, AC (reprint author), Ctr Dis Control & Prevent, Special Bacteriol Reference Lab, Atlanta, GA 30333 USA. EM agn0@cdc.gov FU Intramural CDC HHS [CC999999] NR 25 TC 12 Z9 12 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 EI 1466-5034 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD DEC PY 2013 VL 63 BP 4639 EP 4662 DI 10.1099/ijs.0.054353-0 PN 12 PG 24 WC Microbiology SC Microbiology GA AA2KB UT WOS:000330922400042 PM 23934253 ER PT J AU Branson, BM Ginocchio, CC AF Branson, Bernard M. Ginocchio, Christine C. TI Introduction to 2013 Journal of Clinical Virology Supplement on HIV Testing Algorithms SO JOURNAL OF CLINICAL VIROLOGY LA English DT Editorial Material C1 [Branson, Bernard M.] Ctr Dis Control & Prevent, Diagnost Lab, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Ginocchio, Christine C.] North Shore LIJ Labs, Lake Success, NY USA. [Ginocchio, Christine C.] Hofstra North Shore Sch Med, Hempstead, NY USA. RP Branson, BM (reprint author), Ctr Dis Control & Prevent, Diagnost Lab, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM BBranson@cdc.gov NR 0 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E1 EP E1 DI 10.1016/j.jcv.2013.10.026 PG 1 WC Virology SC Virology GA 302AJ UT WOS:000330573300001 PM 24342467 ER PT J AU Hutchinson, AB Ethridge, SF Wesolowski, LG Shrestha, RK Pentella, M Bennett, B Farnham, PG Sullivan, T Patel, P Branson, BM AF Hutchinson, Angela B. Ethridge, Steven F. Wesolowski, Laura G. Shrestha, Ram K. Pentella, Michael Bennett, Berry Farnham, Paul G. Sullivan, Timothy Patel, Pragna Branson, Bernard M. TI Costs and outcomes of laboratory diagnostic algorithms for the detection of HIV SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE HIV testing algorithms; Costs; Cost-effectiveness ID EMERGENCY-DEPARTMENT; UNITED-STATES; INFECTION; PERFORMANCE; TESTS; SEROCONVERSION; IMMUNOASSAY; ANTIBODY; DONORS; ASSAY AB Background: An alternative HIV testing algorithm, designed to improve the detection of acute and early infections and differentiate between HIV-1 and HIV-2 antibodies, has been developed by the Centers for Disease Control and Prevention and the Association of Public Health Laboratories. While it promises greater sensitivity, it also raises concerns about costs. Objective: We sought to compare the most commonly used algorithm which was developed in 1989, a third-generation (3G) immunoassay (IA) and Western blot confirmatory test, to a newer algorithm. The new algorithm includes either a 3G or a fourth-generation (4G) initial IA, followed by confirmatory testing with a HIV-1 /HIV-2 differentiation IA and, if needed, a nucleic acid amplification test (NAT). Study design: We conducted an analysis of HIV testing costs from the perspective of the laboratory, and classified costs according to IA testing volume. We developed a decision analytic model, populated with cost data from 17 laboratories and published assay performance data, to compare the cost-effectiveness of the testing algorithms for a cohort of 30,000 specimens with a 1% HIV prevalence and 0.1% acute HIV infection prevalence. Results: Costs were lower in high-volume laboratories regardless of testing algorithm. For specimens confirmed positive for HIV antibody, the alternative algorithm (IA, Multispot) was less costly than the current algorithm (IA, WB); however, there was wide variation in reported testing costs. For our cohort, the alternative algorithm initiated with a 3G IA and 4G IA identified 15 and 25 more HIV infections, respectively, than the 1989 algorithm. In medium-volume laboratories, the 1989 algorithm was more costly and less effective than the alternative algorithm with a 3G IA; in high-volume laboratories, the alternative algorithm with 3G IA costs $162 more per infection detected. The alternative algorithm with 4G instead of 3G incurred an additional cost of $14,400 and $4865 in medium- and high-volume labs, respectively. Discussion: HIV testing costs varied with IA testing volumes. The additional cost of 4G over 3G IA might be justified by the additional cases of HIV detected and transmissions averted due to earlier detection. Conclusion: The alternative HIV testing algorithm compares favorably to the 1989 algorithm in terms of cost and effectiveness. Published by Elsevier BY. C1 [Hutchinson, Angela B.; Ethridge, Steven F.; Wesolowski, Laura G.; Shrestha, Ram K.; Farnham, Paul G.; Patel, Pragna; Branson, Bernard M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Pentella, Michael] Univ Iowa, State Hyg Lab, Iowa City, IA USA. [Bennett, Berry] Florida Bur Publ Hlth Labs, Jacksonville, FL USA. [Sullivan, Timothy] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. RP Hutchinson, AB (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM ash2@cdc.gov OI Sullivan, Timothy/0000-0003-3144-9188 NR 34 TC 8 Z9 8 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E2 EP E7 DI 10.1016/j.jcv.2013.10.005 PG 6 WC Virology SC Virology GA 302AJ UT WOS:000330573300002 PM 24342475 ER PT J AU Linley, L Ethridge, SF Oraka, E Owen, SM Wesolowski, LG Wroblewski, K Landgraf, KM Parker, MM Brinson, M Branson, BM AF Linley, Laurie Ethridge, Steven F. Oraka, Emeka Owen, S. Michele Wesolowski, Laura G. Wroblewski, Kelly Landgraf, Kenneth M. Parker, Monica M. Brinson, Myra Branson, Bernard M. TI Evaluation of supplemental testing with the Multispot HIV-1/HIV-2 Rapid Test and APTIMA HIV-1 RNA Qualitative Assay to resolve specimens with indeterminate or negative HIV-1 Western blots SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE HIV testing; Algorithm; Western blot; HIV-1/HIV-2 Rapid Test; HIV-1 NAT; Acute HIV infection ID NUCLEIC-ACID; INFECTION; DIAGNOSIS; TRANSMISSION; IMMUNOASSAY; RATES; BLOOD AB Background: The use of Western blot (WB) as a supplemental test after reactive sensitive initial assays can lead to inconclusive or misclassified HIV test results, delaying diagnosis. Objective: To determine the proportion of specimens reactive by immunoassay (IA) but indeterminate or negative by WB that could be resolved by alternative supplemental tests recommended under a new HIV diagnostic testing algorithm. Study design: Remnant HIV diagnostic specimens that were reactive on 3rd generation HIV-1/2 IA and either negative or indeterminate by HIV-1 WB from 11 health departments were tested with the Bio-Rad Multispot HIV-1/HIV-2 Rapid Test (Multispot) and the Gen-Probe APTIMA HIV-1 RNA Qualitative Assay (APTIMA). Results: According to the new testing algorithm, 512 (89.8%) specimens were HIV-negative, 55 (9.6%) were HIV-1 positive (including 19 [3.3%] that were acute HIV-1 and 9 [1.6%] that were positive for HIV-1 by Multispot but APTIMA-negative), 2 (0.4%) were HIV-2 positive, and 1 (0.2%) was HIV-positive, type undifferentiated. 47(21.4%) of the 220 WB-indeterminate and 8(2.3%) of the 350 WB-negative specimens were HIV-1 positive. Conclusion: Applying the new HIV diagnostic algorithm retrospectively to WB-negative and indeterminate specimens, the HIV infection status could be established for nearly all of the specimens. IA-reactive HIV-infected persons with WB-negative results had been previously misclassified as uninfected, and HIV diagnosis was delayed for those with WB-indeterminate specimens. These findings underscore the limitations of the WB to confirm HIV infection after reactive results from contemporary 3rd or 4th generation IAs that can detect HIV antibodies several weeks sooner than the WB. Published by Elsevier B.V. C1 [Linley, Laurie; Ethridge, Steven F.; Owen, S. Michele; Wesolowski, Laura G.; Branson, Bernard M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Oraka, Emeka] ICF Int, Fairfax, VA USA. [Wroblewski, Kelly; Landgraf, Kenneth M.] Assoc Publ Hlth Labs, Silver Spring, MD USA. [Parker, Monica M.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12237 USA. RP Linley, L (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E-47, Atlanta, GA 30333 USA. EM LLinley@cdc.gov OI Landgraf, Kenneth/0000-0001-5462-0561 FU Centers for Disease Control and Prevention [U60/CD303019] FX This publication was supported in part by Cooperative Agreement Number #U60/CD303019 from the Centers for Disease Control and Prevention. NR 25 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E108 EP E112 DI 10.1016/j.jcv.2013.09.021 PG 5 WC Virology SC Virology GA 302AJ UT WOS:000330573300022 PM 24342469 ER PT J AU Masciotra, S Luo, W Youngpairoj, AS Kennedy, MS Wells, S Ambrose, K Sprinkle, P Owen, SM AF Masciotra, Silvina Luo, Wei Youngpairoj, Ae S. Kennedy, M. Susan Wells, Susan Ambrose, Krystin Sprinkle, Patrick Owen, S. Michele TI Performance of the Alere Determine (TM) HIV-1/2 Ag/Ab Combo Rapid Test with specimens from HIV-1 seroconverters from the US and HIV-2 infected individuals from Ivory Coast SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Diagnostic; HIV-1/2; Rapid test; 4th generation ID DIAGNOSIS; ASSAY AB Background: FDA-approved HIV Antigen/Antibody combo (4th generation) immunoassays (IAs) can identify HIV-1 infections before the Western blot (WB) becomes positive. In the US, increased detection of acute HIV infections has been facilitated by using 4th generation IAs, but there is no FDA-approved 4th generation rapid test (RT). The Alere Determine (TM) HIV-112 Ag/Ab Combo (Determine Combo) RT detects and distinguishes HIV p24 Antigen (Ag) from Antibody (Ab) to HIV-1 + HIV-2 and thus has the potential to improve diagnosis of acute HIV infection. Objective: To evaluate the ability of Determine Combo RT to detect acute/early HIV-1 infections and HIV-2 antibody in well-characterized plasma specimens. Study design: In HIV-1 seroconverters from the US, Determine Combo reactivity was evaluated by performing the 50% cumulative frequency analysis and by comparing with 3rd and 4th generation IAs' reactivity. HIV-2 plasma specimens from Ivory Coast were tested with Determine Combo. Results: The 50% cumulative frequency analysis in 17 seroconverters placed Determine Combo (Ag+/Ab-, Ag+Ab+, Ag-/Ab+) and Ab-component reactivity at 15.5 and 7 days before WB positivity, respectively. In 26 seroconverters, Determine Combo was reactive in 99.0% and 92.5% of 3rd and 4th generation IAs-reactive specimens, respectively. All HIV-2 plasma specimens were Ab-reactive/Ag-non-reactive by Determine Combo. Conclusions: Based on previous results with the same seroconversion panels, combined Ag/Ab reactivity of the Determine Combo appears between FDA-approved 4th and 3rd generation laboratory IAs. These data indicate that this RT could detect HIV-1 infection earlier than other RTs and it performs well in HIV-2 specimens. Published by Elsevier B.V. C1 [Masciotra, Silvina; Luo, Wei; Youngpairoj, Ae S.; Kennedy, M. Susan; Wells, Susan; Ambrose, Krystin; Sprinkle, Patrick; Owen, S. Michele] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Masciotra, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE Mailstop A-25, Atlanta, GA 30333 USA. EM svm6@cdc.gov FU Centers for Disease Control intramural FX Centers for Disease Control intramural fundings. NR 23 TC 17 Z9 17 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E54 EP E58 DI 10.1016/j.jcv.2013.07.002 PG 5 WC Virology SC Virology GA 302AJ UT WOS:000330573300012 PM 23911678 ER PT J AU Masciotra, S Smith, AJ Youngpairoj, AS Sprinkle, P Miles, I Sionean, C Paz-Bailey, G Johnson, JA Owen, SM AF Masciotra, Silvina Smith, Amanda J. Youngpairoj, Ae S. Sprinkle, Patrick Miles, Isa Sionean, Catlainn Paz-Bailey, Gabriela Johnson, Jeffrey A. Owen, S. Michele TI Evaluation of the CDC proposed laboratory HIV testing algorithm among men who have sex with men (MSM) from five US metropolitan statistical areas using specimens collected in 2011 SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE HIV-1; Diagnostics; Algorithms; Laboratory ID HIV-1/HIV-2 RAPID TEST; NUCLEIC-ACID; SEROCONVERSION PANELS; WESTERN-BLOT; P24 ANTIGEN; INFECTION; IMMUNOASSAY; ANTIBODY; RISK; PREVENTION AB Background: Until recently most testing algorithms in the United States (US) utilized Western blot (WB) as the supplemental test. CDC has proposed an algorithm for HIV diagnosis which includes an initial screen with a Combo Antigen/Antibody 4th generation-immunoassay (IA), followed by an HIV-112 discriminatory IA of initially reactive-IA specimens. Discordant results in the proposed algorithm are resolved by nucleic acid-amplification testing (NAAT). Objectives: Evaluate the results obtained with the CDC proposed laboratory-based algorithm using specimens from men who have sex with men (MSM) obtained in five metropolitan statistical areas (MSAs). Study design: Specimens from 992 MSM from five MSAs participating in the CDC's National HIV Behavioral Surveillance System in 2011 were tested at local facilities and CDC. The five MSAs utilized algorithms of various screening assays and specimen types, and WB as the supplemental test. At the CDC, serum/plasma specimens were screened with 4th generation-IA and the Multispot HIV-1/HIV-2 discriminatory assay was used as the supplemental test. NAAT was used to resolve discordant results and to further identify acute HIV infections from all screened-non-reactive missed by the proposed algorithm. Performance of the proposed algorithm was compared to site-specific WB-based algorithms. Results: The proposed algorithm detected 254 infections. The WB-based algorithms detected 19 fewer infections; 4 by oral fluid (OF) rapid testing and 15 by WB supplemental testing (12 OF and 3 blood). One acute infection was identified by NAAT from all screened-non-reactive specimens. Conclusions: The proposed algorithm identified more infections than the WB-based algorithms in a highrisk MSM population. OF testing was associated with most of the discordant results between algorithms. HIV testing with the proposed algorithm can increase diagnosis of infected individuals, including early infections. Published by Elsevier B.V. C1 [Masciotra, Silvina; Smith, Amanda J.; Youngpairoj, Ae S.; Sprinkle, Patrick; Miles, Isa; Sionean, Catlainn; Paz-Bailey, Gabriela; Johnson, Jeffrey A.; Owen, S. Michele] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Masciotra, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE Mailstop A-25, Atlanta, GA 30333 USA. EM svm6@cdc.gov FU Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Division of HIV/AIDS Prevention [PS11-001] FX This work was supported by the Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Division of HIV/AIDS Prevention Funding Opportunity Announcement Number PS11-001: National HIV Behavioral Surveillance. NR 36 TC 9 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E8 EP E12 DI 10.1016/j.jcv.2013.09.002 PG 5 WC Virology SC Virology GA 302AJ UT WOS:000330573300003 PM 24342483 ER PT J AU Pandori, MW Westheimer, E Gay, C Moss, N Fu, J Hightow-Weidman, LB Craw, J Hall, L Giancotti, FR Mak, ML Madayag, C Tsoi, B Louie, B Patel, P Owen, SM Peters, PJ AF Pandori, Mark W. Westheimer, Emily Gay, Cindy Moss, Nicholas Fu, Jie Hightow-Weidman, Lisa B. Craw, Jason Hall, Laura Giancotti, Francesca R. Mak, Mae Ling Madayag, Carmela Tsoi, Benjamin Louie, Brian Patel, Pragna Owen, S. Michele Peters, Philip J. TI The Multispot rapid HIV-1/HIV-2 differentiation assay is comparable with the Western blot and an immunofluorescence assay at confirming HIV infection in a prospective study in three regions of the United States SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE HIV; HIV serodiagnosis; Algorithms ID DIAGNOSIS; ALGORITHM; TESTS; TRANSMISSION AB Background: A new HIV diagnostic algorithm has been proposed which replaces the use of the HIV-1 Western blot and HIV-1 immunofluorescence assays (IFA) as the supplemental test with an HIV-1/HIV-2 antibody differentiation assay. Objectives: To compare an FDA-approved HIV-1/HIV-2 antibody differentiation test (Multispot) as a confirmatory test with the HIV-1 Western blot and IFA. Study design: Participants were screened with an HIV-1/HIV-2 combination Antigen/Antibody (Ag/Ab) screening assay. Specimens with repeatedly reactive results were tested with Multispot and either Western blot or IFA. Specimens with discordant screening and confirmatory results were resolved with HIV-1 RNA testing. Results: Individuals (37,876) were screened for HIV infection and 654 (1.7%) had a repeatedly reactive Ag/Ab assay result. On Multispot, 554 (84.7%) were HIV-1 reactive, 0 (0%) were HIV-2 reactive, 1(0.2%) was reactive for both HIV-1 and HIV-2 (undifferentiated), 9 (1.4%) were HIV-1 indeterminate, and 90 (13.8%) were non-reactive. HIV-1 RNA was detected in 47190 Multispot non-reactive (52.2%) specimens. Among specimens confirmed to have HIV infection (true positives), Multispot and Western blot detected HIV-1 antibody in a similar proportion of cases (93.7% vs. 94.4% respectively) while Multispot and IFA also detected HIV-1 antibody in a similar proportion of cases (84.5% vs. 83.4% respectively). Conclusions: In this study, Multispot confirmed HIV infections at a similar proportion to Western blot and IFA. Multispot, Western blot, and IFA, however, did not confirm all of the reactive Ag/Ab assay results and underscores the importance of HIV NAT testing to resolve discordant screening and confirmatory results. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved. C1 [Pandori, Mark W.; Mak, Mae Ling; Madayag, Carmela; Louie, Brian] San Francisco Dept Publ Hlth, San Francisco, CA 94122 USA. [Westheimer, Emily; Fu, Jie; Giancotti, Francesca R.; Tsoi, Benjamin] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Gay, Cindy; Hightow-Weidman, Lisa B.] Univ N Carolina, Chapel Hill, NC USA. [Moss, Nicholas] Alameda Cty Dept Publ Hlth, Oakland, CA USA. [Craw, Jason; Hall, Laura] ICF Int, Atlanta, GA USA. [Patel, Pragna; Owen, S. Michele; Peters, Philip J.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RP Pandori, MW (reprint author), San Francisco Dept Publ Hlth, 101 Grove St,Room 419, San Francisco, CA 94122 USA. EM Mark_Pandori@sfdph.org FU CDC STOP project FX CDC STOP project. NR 16 TC 11 Z9 11 U1 3 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E92 EP E96 DI 10.1016/j.jcv.2013.10.006 PG 5 WC Virology SC Virology GA 302AJ UT WOS:000330573300019 PM 24342485 ER PT J AU Stekler, JD O'Neal, JD Lane, A Swanson, F Maenza, J Stevens, CE Coombs, RW Dragavon, JA Swenson, PD Golden, MR Branson, BM AF Stekler, Joanne D. O'Neal, Joshua D. Lane, Aric Swanson, Fred Maenza, Janine Stevens, Claire E. Coombs, Robert W. Dragavon, Joan A. Swenson, Paul D. Golden, Matthew R. Branson, Bernard M. TI Relative accuracy of serum, whole blood, and oral fluid HIV tests among Seattle men who have sex with men SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE HIV testing; Rapid HIV test; Oral fluids ID ANTIBODY TESTS; INFECTION; SEROCONVERSION; TRANSMISSION; METAANALYSIS; SENSITIVITY; SPECIMENS; DIAGNOSIS; ASSAYS; PANELS AB Background: Point-of-care (POC) rapid HIV tests have sensitivity during the "window period" comparable only to earliest generation EIAs. To date, it is unclear whether any POC test performs significantly better than others. Objective: Compare abilities of POC tests to detect early infection in real time. Study design: Men who have sex with men (MSM) were recruited into a prospective, cross-sectional study at two HIV testing sites and a research clinic. Procedures compared four POC tests: one performed on oral fluids and three on fingerstick whole blood specimens. Specimens from participants with negative POC results were tested by EIA and pooled nucleic acid amplification testing (NAAT). McNemar's exact tests compared numbers of HIV-infected participants detected. Results: Between February 2010 and May 2013, 104 men tested HIV-positive during 2479 visits. Eighty-two participants had concordant reactive POC results, 3 participants had concordant non-reactive POC tests but reactive EIAs, and 8 participants had acute infection. Of 12 participants with discordant POC results, OraQuick ADVANCE Rapid HIV-1/2 Antibody Test performed on oral fluids identified fewer infections than OraQuick performed on fingerstick (p=005), Uni-Gold Recombigen HIV test (p=.01), and determine HIV-1/2 Ag/Ab combo (p=005). Conclusions: These data confirm that oral fluid POC testing detects fewer infections than other methods and is best reserved for circumstances precluding fingerstick or venipuncture. Regardless of specimen type, POC tests failed to identify many HIV-infected MSM in Seattle. In populations with high HIV incidence, the currently approved POC antibody tests are inadequate unless supplemented with p24 antigen tests or NAAT. (C) 2013 Elsevier B.V. All rights reserved. C1 [Stekler, Joanne D.; O'Neal, Joshua D.; Maenza, Janine; Stevens, Claire E.; Coombs, Robert W.; Golden, Matthew R.] Univ Washington, Dept Med, Seattle, WA USA. [Stekler, Joanne D.; Golden, Matthew R.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Coombs, Robert W.; Dragavon, Joan A.] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [Stekler, Joanne D.; Lane, Aric; Swenson, Paul D.; Golden, Matthew R.] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Swanson, Fred] Gay City Hlth Project, Seattle, WA USA. [Branson, Bernard M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Stekler, JD (reprint author), Univ Washington, Harborview Med Ctr, Box 359931,325 9th Ave, Seattle, WA 98104 USA. EM jstekler@uw.edu OI Lane, Aric/0000-0003-1842-0647 FU NIH [R01 MH-86360, U01 AI-38858, UM1 AI-068618, P30 AI-27757] FX NIH R01 MH-86360, U01 AI-38858, UM1 AI-068618, and P30 AI-27757. NR 30 TC 15 Z9 15 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2013 VL 58 SU 1 BP E119 EP E122 DI 10.1016/j.jcv.2013.09.018 PG 4 WC Virology SC Virology GA 302AJ UT WOS:000330573300024 PM 24342471 ER PT J AU Emerson, JA Walden, HS Peters, RK Farina, LL Fredholm, DV Qvarnstrom, Y Xayavong, M Bishop, H Slapcinsky, J McIntosh, A Wellehan, JFX AF Emerson, Jessica A. Walden, Heather Stockdale Peters, Rosanne K. Farina, Lisa L. Fredholm, Daniel V. Qvarnstrom, Yvonne Xayavong, Maniphet Bishop, Henry Slapcinsky, John McIntosh, Antoinette Wellehan, James F. X., Jr. TI Eosinophilic meningoencephalomyelitis in an orangutan (Pongo pygmaeus) caused by Angiostrongylus cantonensis SO VETERINARY QUARTERLY LA English DT Article DE orangutan; Pongo pygmaeus; primate; Angiostrongylus cantonensis; Zachrysia provisoria; meningitis; eosinophilia; rat; real-time PCR ID MENINGITIS; HAWAII; RATS C1 [Emerson, Jessica A.; Peters, Rosanne K.; Fredholm, Daniel V.; Wellehan, James F. X., Jr.] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32608 USA. [Walden, Heather Stockdale; Farina, Lisa L.; McIntosh, Antoinette] Univ Florida, Coll Vet Med, Gainesville, FL 32608 USA. [Qvarnstrom, Yvonne; Xayavong, Maniphet; Bishop, Henry] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Slapcinsky, John] Univ Florida, Florida Museum Nat Hist, Gainesville, FL 32611 USA. RP Emerson, JA (reprint author), Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, 2015 SW 16th Ave, Gainesville, FL 32608 USA. EM emersonj@ufl.edu OI Wellehan, Jim/0000-0001-5692-6134 NR 22 TC 5 Z9 5 U1 0 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0165-2176 EI 1875-5941 J9 VET QUART JI Vet. Q. PD DEC 1 PY 2013 VL 33 IS 4 BP 191 EP 194 DI 10.1080/01652176.2013.880005 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA AA2OC UT WOS:000330932900003 PM 24512524 ER PT J AU Asfaw, A Rosa, R Mao, R AF Asfaw, Abay Rosa, Roger Mao, Rebecca TI Do Zero-Cost Workers' Compensation Medical Claims Really Have Zero Costs? The Impact of Workplace Injury on Group Health Insurance Utilization and Costs SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID BACK-PAIN CLAIMS; OCCUPATIONAL INJURY; NARRATIVE ANALYSIS; BENEFITS; DISABILITY; DISORDERS; ILLNESS; LENGTH; STATES AB Objective: Previous research suggests that non-workers' compensation (WC) insurance systems, such as group health insurance (GHI), Medicare, or Medicaid, at least partially cover work-related injury and illness costs. This study further examined GHI utilization and costs. Methods: Using two-part model, we compared those outcomes immediately after injuries for which accepted WC medical claims made zero or positive medical payments. Results: Controlling for pre-injury GHI utilization and costs and other covariates, our results indicated that post-injury GHI utilization and costs increased regardless of whether a WC medical claim was zero or positive. The increases were highest for zero-cost WC medical claims. Conclusion: Our national estimates showed that zero-cost WC medical claims alone could cost the GHI $212 million per year. C1 [Asfaw, Abay; Rosa, Roger; Mao, Rebecca] NIOSH, Off Director, Ctr Dis Control & Prevent, Washington, DC 20201 USA. RP Asfaw, A (reprint author), NIOSH, Off Director, Ctr Dis Control & Prevent, 395 E St SW, Washington, DC 20201 USA. EM hqp0@cdc.gov FU Intramural CDC HHS [CC999999] NR 26 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 2013 VL 55 IS 12 BP 1394 EP 1400 DI 10.1097/JOM.0000000000000030 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 300FK UT WOS:000330449600005 PM 24316724 ER PT J AU White, GE Mazurek, JM Moorman, JE AF White, Gretchen E. Mazurek, Jacek M. Moorman, Jeanne E. TI Asthma in Health Care Workers 2008 and 2010 Behavioral Risk Factor Surveillance System Asthma Call-Back Survey SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID OCCUPATIONAL RISK-FACTORS; NATIONAL-HEALTH; ONSET ASTHMA; PROFESSIONALS; POPULATION; PREVALENCE; INDUSTRY AB Objective: To estimate the prevalence of current asthma and the proportion of asthma that is work-related among health care and non-health care workers. Methods: We used 2008 and 2010 Behavioral Risk Factor Surveillance System High Risk/Health Care Worker Module and Asthma Call-Back Survey data collected in 35 states and the District of Columbia to estimate prevalence ratios (PRs). Results: Significantly more health care workers/volunteers than non-health care workers/volunteers with current asthma had asthma attacks (PR = 1.23; 95% confidence interval = 1.03 to 1.46) and asthma symptoms within the past year (PR = 1.07; 95% confidence interval = 1.00 to 1.14). There was no significant difference in the proportion of health care and non-health care workers/volunteers diagnosed with current asthma or work-related asthma. Conclusions: The results of this study are consistent with previous research showing that health care workers with asthma have higher proportions of asthma attacks than non-health care workers. C1 [White, Gretchen E.; Mazurek, Jacek M.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV USA. [Moorman, Jeanne E.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP White, GE (reprint author), 1095 Willowdale Rd,MS HG 900, Morgantown, WV 26505 USA. EM ipb8@cdc.gov FU Intramural CDC HHS [CC999999] NR 19 TC 1 Z9 1 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 2013 VL 55 IS 12 BP 1463 EP 1468 DI 10.1097/JOM.0000000000000006 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 300FK UT WOS:000330449600015 PM 24270301 ER PT J AU Moro, PL Museru, OI Broder, K Cragan, J Zheteyeva, Y Tepper, N Revzina, N Lewis, P Arana, J Barash, F Kissin, D Vellozzi, C AF Moro, Pedro L. Museru, Oidda I. Broder, Karen Cragan, Janet Zheteyeva, Yenlik Tepper, Naomi Revzina, Natalia Lewis, Paige Arana, Jorge Barash, Faith Kissin, Dmitry Vellozzi, Claudia TI Safety of Influenza A (H1N1) 2009 Live Attenuated Monovalent Vaccine in Pregnant Women SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID IMMUNIZATION PRACTICES ACIP; ADVISORY-COMMITTEE; UNITED-STATES; FETAL-DEATH; RECOMMENDATIONS; PREVENTION; COHORT; RISK AB OBJECTIVE: To characterize maternal and infant outcomes for pregnant women who received live H1N1 influenza vaccine and had no reported adverse events. METHODS: We identified Vaccine Adverse Event Reporting System reports, which described receipt of live H1N1 vaccine during pregnancy without an indication of an adverse event at the time of the report during October 2009 to June 2010. We reviewed the initial reports and obtained pregnancy outcome and infant data through 6 months of age from medical records. We reviewed the numbers and characteristics of pregnancy complications and infant outcomes including major birth defects and medically important infant conditions. Rates of spontaneous abortion, preterm birth, and major birth defects and their 95% confidence intervals were calculated. RESULTS: The Vaccine Adverse Event Reporting System received 113 reports stating receipt of live H1N1 vaccine during pregnancy with no adverse events reported. We obtained follow-up maternal records on 95 of the 113 (84%) live H1N1 reports (40.2% were vaccinated in the first trimester) and found: 87 live births (two twin pregnancies) and no maternal deaths occurred. Number and rates of pregnancy-specific adverse events included: 10 (10.5%, 5.8-18.3) spontaneous abortions; four (4.7%, 1.8-11.4) preterm deliveries at 35-36 weeks of gestation; three (3.4%, 1.2-9.7) infants had one or more major birth defects noted at birth: one cleft palate, one cleft lip, and one microtia (underdeveloped or absent external ear). Seven neonates and infants were hospitalized for medically important conditions. One infant death occurred in a 2.5-month-old boy as a result of pertussis. CONCLUSION: Rates of spontaneous abortion, preterm birth, and major birth defects in pregnant women who received live H1N1 vaccine were similar to or lower than published background rates. No concerning patterns of medical conditions in infants were identified. C1 Ctr Dis Control & Prevent, Immunizat Safety Off,Natl Ctr Birth Defects & Dev, Div Healthcare Qual Promot,Div Birth Defects & De, Natl Ctr Emerging & Zoonot Infect Dis,Birth Defec, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. Emory Sch Med, Dept Pediat, Atlanta, GA USA. US FDA, Off Biostat & Epidemiol, Ctr Biol Evaluat & Res, Silver Spring, MD USA. RP Moro, PL (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, 1600 Clifton Rd,MS D26, Atlanta, GA 30333 USA. EM pmoro@cdc.gov FU Centers for Disease Control and Prevention; U.S. Food and Drug Administration FX Funded by the Centers for Disease Control and Prevention and the U.S. Food and Drug Administration. NR 30 TC 18 Z9 18 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD DEC PY 2013 VL 122 IS 6 BP 1271 EP 1278 DI 10.1097/AOG.0000000000000010 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 300FV UT WOS:000330450700018 PM 24201689 ER PT J AU Mhyre, JM Shilkrut, A Kuklina, EV Callaghan, WM Creanga, AA Kaminsky, S Bateman, BT AF Mhyre, Jill M. Shilkrut, Alexander Kuklina, Elena V. Callaghan, William M. Creanga, Andreea A. Kaminsky, Sari Bateman, Brian T. TI Massive Blood Transfusion During Hospitalization for Delivery in New York State, 1998-2007 SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID POSTPARTUM HEMORRHAGE; OBSTETRIC HEMORRHAGE; MATERNAL MORTALITY; PLACENTA-ACCRETA; MORBIDITY; CARE; TRENDS; RISK AB OBJECTIVE: To define the frequency, risk factors, and outcomes of massive transfusion in obstetrics. METHODS: The State Inpatient Dataset for New York (1998-2007) was used to identify all delivery hospitalizations for hospitals that reported at least one delivery-related transfusion per year. Multivariable logistic regression analysis was performed to examine the relationship between maternal age, race, and relevant clinical variables and the risk of massive blood transfusion defined as 10 or more units of blood recorded. RESULTS: Massive blood transfusion complicated 6 of every 10,000 deliveries with cases observed even in the smallest facilities. Risk factors with the strongest independent associations with massive blood transfusion included abnormal placentation (1.6/10,000 deliveries, adjusted odds ratio [OR] 18.5, 95% confidence interval [CI] 14.7-23.3), placental abruption (1.0/10,000, adjusted OR 14.6, 95% CI 11.2-19.0), severe preeclampsia (0.8/10,000, adjusted OR 10.4, 95% CI 7.7-14.2), and intrauterine fetal demise (0.7/10,000, adjusted OR 5.5, 95% CI 3.9-7.8). The most common etiologies of massive blood transfusion were abnormal placentation (26.6% of cases), uterine atony (21.2%), placental abruption (16.7%), and postpartum hemorrhage associated with coagulopathy (15.0%). A disproportionate number of women who received a massive blood transfusion experienced severe morbidity including renal failure, acute respiratory distress syndrome, sepsis, and in-hospital death. CONCLUSION: Massive blood transfusion was infrequent, regardless of facility size. In the presence of known risk for receipt of massive blood transfusion, women should be informed of this possibility, should deliver in a well-resourced facility if possible, and should receive appropriate blood product preparation and venous access in advance of delivery. C1 Univ Michigan Hlth Syst, Dept Anesthesiol, Ann Arbor, MI USA. New York Med Coll, Dept Obstet & Gynecol, Valhalla, NY 10595 USA. Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. Harvard Univ, Brigham & Womens Hosp, Sch Med,Dept Med,Div Pharmacoepidemiol & Pharmaco, Dept Anesthesiol Crit Care & Pain Med,Massachuset, Boston, MA 02115 USA. RP Mhyre, JM (reprint author), Univ Arkansas Med Sci, Dept Anesthesiol, 4301 West Markham St,Slot 515, Little Rock, AR 72205 USA. EM jmmhyre@uams.edu FU Intramural CDC HHS [CC999999] NR 26 TC 21 Z9 22 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD DEC PY 2013 VL 122 IS 6 BP 1288 EP 1294 DI 10.1097/AOG.0000000000000021 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 300FV UT WOS:000330450700020 PM 24201690 ER PT J AU Meza, F Chen, LL Hudson, N AF Meza, Francisco Chen, Lilia Hudson, Naomi TI Investigation of Respiratory and Dermal Symptoms Associated With Metal Working Fluids at an Aircraft Engine Manufacturing Facility SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE metalworking fluid; MWF; thoracic particulates; asthma; dermatitis; endotoxin; mycobacteria; microbial contamination; fungi; aircraft engine manufacturing ID HYPERSENSITIVITY PNEUMONITIS; ASTHMA; EXPOSURE; PREVENTION; PREVALENCE; DISEASE AB BackgroundEach year, 1.2 million metalworkers are exposed to metalworking fluids (MWFs), which can cause dermal and respiratory disease. The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation of MWF exposures at an aircraft engine manufacturing facility. The objectives were to determine employee exposures to endotoxin and MWFs in the air, characterize symptoms experienced by employees working with MWFs, compare them to symptoms of employees unexposed to MWFs, and make recommendations for reducing exposures based on results. MethodsFour hundred seven workers were categorized as MWF exposed or MWF unexposed and completed questionnaires. Estimated prevalence ratios (PR) of dermatitis, asthma, and work-related asthma (WRA) symptoms were calculated. Airborne concentrations of MWF and endotoxin were measured, and work practices observed. ResultsMWF exposed workers had a significantly higher prevalence of dermatitis on wrists/forearms (PR 2.59; 95% CI 1.22, 5.46), asthma symptoms (PR 1.49; 95% CI 1.05, 2.13), and WRA symptoms (PR 2.10; 95% CI 1.22, 3.30) than unexposed workers. Airborne concentrations of MWF were below the NIOSH recommended exposure limit (REL) for MWF aerosols (thoracic particulate mass). ConclusionsDespite MWF exposures below the NIOSH REL, exposed workers had a higher prevalence of asthma, WRA, and dermatitis symptoms than unexposed workers. Recommendations to reduce exposure included configuring mist collectors to automatically turn on when the machine is in use, and enforcing enclosure use. Am. J. Ind. Med. 56:1394-1401, 2013. (c) 2013 Wiley Periodicals, Inc. C1 [Meza, Francisco; Chen, Lilia; Hudson, Naomi] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Chen, LL (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,Mailstop R-10, Cincinnati, OH 45226 USA. EM fto3@cdc.gov FU National Institute for Occupational Safety and Health FX Contract grant sponsor: National Institute for Occupational Safety and Health. NR 25 TC 3 Z9 3 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD DEC PY 2013 VL 56 IS 12 BP 1394 EP 1401 DI 10.1002/ajim.22253 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 294IZ UT WOS:000330040200003 PM 24122918 ER PT J AU Sinclair, RC Cunningham, TR Schulte, PA AF Sinclair, Raymond C. Cunningham, Thomas R. Schulte, Paul A. TI A Model for Occupational Safety and Health Intervention Diffusion to Small Businesses SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE small business; occupational safety; occupational health; intervention model ID SMALL ENTERPRISES; SIZE; MANAGEMENT; INDUSTRY; ILLNESS; RISK AB BackgroundSmaller businesses differ from their larger counterparts in having higher rates of occupational injuries and illnesses and fewer resources for preventing those losses. Intervention models developed outside the United States have addressed the resource deficiency issue by incorporating intermediary organizations such as trade associations. MethodsThis paper extends previous models by using exchange theory and by borrowing from the diffusion of innovations model. It emphasizes that occupational safety and health (OSH) organizations must understand as much about intermediary organizations as they do about small businesses. OSH organizations (initiators) must understand how to position interventions and information to intermediaries as added value to their relationships with small businesses. Examples from experiences in two midwestern states are used to illustrate relationships and types of analyses implied by the extended model. ResultsThe study found that intermediary organizations were highly attuned to providing smaller businesses with what they want, including OSH services. The study also found that there are opinion leader organizations and individual champions within intermediaries who are key to decisions and actions about OSH programming. ConclusionsThe model places more responsibility on both initiators and intermediaries to develop and market interventions that will be valued in the competitive small business environment where the resources required to adopt each new business activity could always be used in other ways. The model is a candidate for empirical validation, and it offers some encouragement that the issue of sustainable OSH assistance to small businesses might be addressed. Am. J. Ind. Med. 56:1442-1451, 2013. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. C1 [Sinclair, Raymond C.; Cunningham, Thomas R.; Schulte, Paul A.] NIOSH, Ctr Dis Control & Prevent, Educ & Informat Div, Cincinnati, OH 45226 USA. RP Sinclair, RC (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM rsinclair@cdc.gov FU Intramural CDC HHS [CC999999] NR 39 TC 6 Z9 6 U1 2 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD DEC PY 2013 VL 56 IS 12 BP 1442 EP 1451 DI 10.1002/ajim.22263 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 294IZ UT WOS:000330040200008 PM 24115112 ER PT J AU Hunter, AS AF Hunter, Alicia S. TI Weight of the Nation - Moving Forward, Reversing the Trend SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Hunter, AS (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 5 EP 7 DI 10.1111/jlme.12103 PG 3 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800001 PM 24446992 ER PT J AU Reynolds, MA Cotwright, CJ Polhamus, B Gertel-Rosenberg, A Chang, D AF Reynolds, Meredith A. Cotwright, Caree Jackson Polhamus, Barbara Gertel-Rosenberg, Allison Chang, Debbie TI Obesity Prevention in the Early Care and Education Setting: Successful Initiatives across a Spectrum of Opportunities SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID TRACKING; CHILDREN AB With an estimated 12.1% of children aged 2-5 years already obese, prevention efforts must target our youngest children. One of the best places to reach young children for such efforts is the early care and education setting (ECE). More than 11 million U.S. children spend an average of 30 hours per week in ECE facilities. Increased attention at the national, state, and community level on the ECE setting for early obesity prevention efforts has sparked a range of innovative efforts. To assist these efforts, CDC developed a technical assistance and training framework - the Spectrum of Opportunities for Obesity Prevention in the ECE setting - which also served as the organizing framework for the Weight of the Nation ECE track. Participants highlighted their efforts at national, state, and local levels pursuing opportunities on the Spectrum, the standards and best practices that had been the emphasis of their efforts, and common steps for developing, implementing, and evaluating initiatives. Strong leadership and collaboration among a broad group of stakeholders; systematic assessment of needs, opportunities and resources; funding sources; and training and professional development were reported to be integral for successful implementation of standards and best practices, and sustainability. C1 [Reynolds, Meredith A.] Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Cotwright, Caree Jackson] Univ Georgia, Coll Family & Consumer Sci, Athens, GA 30602 USA. [Polhamus, Barbara] Ctr Dis Control & Prevent, Program Dev & Evaluat Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Gertel-Rosenberg, Allison] Nemours, Natl Prevent & Practice, Newark, DE USA. [Chang, Debbie] Nemours, Policy & Prevent, Washington, DC USA. RP Reynolds, MA (reprint author), Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. FU Child Care and Development Fund; Temporary Assistance for Needy Families, Head Start, Social Service Block Grants; CACFP; Maternal and Child Health Block Grants FX States, through their general funds, typically invest in ECE over and above the allocations they receive from several federal government programs (e.g., Child Care and Development Fund, Temporary Assistance for Needy Families, Head Start, Social Service Block Grants, CACFP, and Maternal and Child Health Block Grants). As of FY 2011, states were appropriating $18.5 billion of state funds to ECE for services such as child care, pre-K, home visiting, and other early learning strategies. 33 In many states, the department of education and local school districts provide funds to support preschool and afterschool child care providers and expand Head Start programs. In some states, the legislature has authorized state funds to develop QRIS for ECE. NR 30 TC 3 Z9 3 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 8 EP 18 DI 10.1111/jlme.12104 PG 11 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800002 PM 24446993 ER PT J AU Foltz, JL Belay, B Blackburn, GL AF Foltz, Jennifer L. Belay, Brook Blackburn, George L. TI Improving the Weight of the Nation by Engaging the Medical Setting in Obesity Prevention and Control SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID HEALTH AB This manuscript highlights examples of strategies that have made strides in improving the quality of health care environments, systems-level improvements to support self-management, and collaborations between primary care and public health to support effective approaches to prevent obesity among children and adults in the U.S. C1 [Foltz, Jennifer L.; Belay, Brook] Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Foltz, Jennifer L.] US Public Hlth Serv Commissioned Corp, Atlanta, GA USA. [Blackburn, George L.] Harvard Univ, Sch Med, Dept Surg, Beth Israel Deaconess Med Ctr,Ctr Study Nutr Med, Boston, MA 02115 USA. RP Foltz, JL (reprint author), Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 15 TC 1 Z9 1 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 19 EP 26 DI 10.1111/jlme.12105 PG 8 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800003 PM 24446994 ER PT J AU Nihiser, A Merlo, C Lee, S AF Nihiser, Allison Merlo, Caitlin Lee, Sarah TI Preventing Obesity through Schools SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID ADOLESCENTS; EDUCATION; HEALTH AB This paper describes highlights from the Weight of the Nation 2012 Schools Track. Included is a summary of 16 presentations. Presenters shared key actions for obesity prevention through schools. The information provided at the Weight of the Nation can help school health practitioners access tools, apply evidence-based strategies, and model real-world examples to successfully start obesity prevention initiatives in their jurisdiction. C1 [Nihiser, Allison; Merlo, Caitlin; Lee, Sarah] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA 30333 USA. RP Nihiser, A (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 31 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 27 EP 34 DI 10.1111/jlme.12106 PG 8 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800004 PM 24446995 ER PT J AU Sommers, JK Heiser, C AF Sommers, Janice K. Heiser, Claire TI The Role of Community, State, Territorial, and Tribal Public Health in Obesity Prevention SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article AB This article explores how governmental public health authorities can contribute to public health efforts to address obesity by monitoring the prevalence of obesity and associated risk factors, investigating the contributing factors, informing the public, and working with the citizens in their jurisdiction to develop solutions that fit the needs and sensibilities of the people. C1 [Sommers, Janice K.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA. [Heiser, Claire] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Sommers, JK (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 35 EP 39 DI 10.1111/jlme.12107 PG 5 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800005 PM 24446996 ER PT J AU Lankford, T Lang, J Bowden, B Baun, W AF Lankford, Tina Lang, Jason Bowden, Brian Baun, William TI Workplace Health: Engaging Business Leaders to Combat Obesity SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID COSTS; TIME AB This article explores how employers can be part of the solution to obesity by offering workplace wellness programs and facilitating opportunities for physical activity, access to healthier foods and beverages, and incentives for disease management and prevention to help prevent weight gain among their employees. C1 [Bowden, Brian] Ctr Dis Control & Prevent, Off Associate Director Policy, Atlanta, GA USA. [Baun, William] Houston Wellness Assoc, Board Int Assoc Worksite Hlth Promot, Houston, TX USA. NR 16 TC 1 Z9 1 U1 3 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 40 EP 45 DI 10.1111/jlme.12108 PG 6 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800006 PM 24446997 ER PT J AU Trowbridge, MJ Schmid, TL AF Trowbridge, Matthew J. Schmid, Thomas L. TI Built Environment and Physical Activity Promotion: Place-Based Obesity Prevention Strategies SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID HEALTH; TRAVEL AB This paper seeks to encourage continued innovation in translating built environment and transportation-focused physical activity research into practice. Successful strategies, policies, and tools from across the U.S. and globally that demonstrate potential for wider-scale implementation are highlighted. The importance of building practice and translational research partnerships with groups and organizations outside traditional public health spheres, such as those who work in real estate and land-use development, is also discussed. C1 [Trowbridge, Matthew J.] Univ Virginia, Dept Emergency Med, Sch Med, Charlottesville, VA 22903 USA. [Schmid, Thomas L.] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Trowbridge, MJ (reprint author), Univ Virginia, Dept Emergency Med, Sch Med, Charlottesville, VA 22903 USA. NR 38 TC 4 Z9 4 U1 2 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD DEC PY 2013 VL 41 SU 2 SI SI BP 46 EP 51 DI 10.1111/jlme.12109 PG 6 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA 292SO UT WOS:000329922800007 PM 24446998 ER PT J AU Phiri, S Zadrozny, S Weiss, HA Martinson, F Nyirenda, N Chen, CY Miller, WC Cohen, MS Mayaud, P Hoffman, IF AF Phiri, Sam Zadrozny, Sabrina Weiss, Helen A. Martinson, Francis Nyirenda, Naomi Chen, Cheng-Yen Miller, William C. Cohen, Myron S. Mayaud, Philippe Hoffman, Irving F. TI Etiology of Genital Ulcer Disease and Association With HIV Infection in Malawi SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SIMPLEX-VIRUS TYPE-2; SEXUALLY-TRANSMITTED-DISEASES; HERPES; MANAGEMENT; TRANSMISSION; ACQUISITION; URETHRITIS; ACYCLOVIR; IMPACT; TRIAL AB Background: The World Health Organization recommends the use of syndromic management for patients presenting with genital ulcer disease (GUD) in developing countries. However, effective treatment guidelines depend on a current country-specific GUD etiological profile, which may change over time. Methods: From 2004 to 2006, we conducted a cross-sectional analysis of baseline data from patients presenting with GUD at a reference STI clinic in Lilongwe, Malawi. Participants were enrolled in a randomized clinical trial of acyclovir added to syndromic management and followed up for up to 28 days. Serologies for HIV (using parallel rapid tests), herpes simplex virus type 2 (HSV-2; using Focus HerpeSelect IgG2 ELISA [Focus Technologies, Cypress Hill, CA]), and syphilis (rapid plasma reagin confirmed by Treponema pallidum hemagglutination) were determined, with plasma HIV-1 RNA and CD4 count in HIV-positive patients. Genital ulcer disease etiology was determined by real-time multiplex polymerase chain reaction from lesional swabs. Results: A total of 422 patients with GUD (313 men; 74%) were enrolled. Overall seroprevalence of HIV-1, HSV-2, and syphilis were 61%, 72%, and 5%, respectively. Ulcer etiology was available for 398 patients and showed the following: HSV-2, 67%; Haemophilus ducreyi, 15%; T. pallidum, 6%; lymphogranuloma venereum, 6%; mixed infections, 14%, and no etiology, 20%. Most HSV-2 ulcers were recurrent (75%). Among all patients with HSV-2, HIV prevalence was high (67%) and HIV seroprevalence was higher among patients with recurrent HSV-2 compared with patients with first-episode HSV-2 (78% vs. 39%, P G 0.001). Conclusions: Herpes simplex virus type 2 ulcers are highly prevalent in this symptomatic population and strongly associated with HIV. Unlike most locations in sub-Saharan Africa, H. ducreyi remains prevalent in this population and requires periodic monitoring and an appropriate treatment regimen. C1 [Phiri, Sam] Kamuzu Cent Hosp, Lighthouse Ctr, Lilongwe, Malawi. [Phiri, Sam; Zadrozny, Sabrina; Miller, William C.; Cohen, Myron S.; Hoffman, Irving F.] Univ N Carolina, Chapel Hill, NC USA. [Weiss, Helen A.; Martinson, Francis; Nyirenda, Naomi] London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, London WC1, England. [Chen, Cheng-Yen] Univ North Carolina Project, Lilongwe, Malawi. [Chen, Cheng-Yen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mayaud, Philippe] London Sch Hyg & Trop Med, Clin Res Unit, London WC1, England. RP Phiri, S (reprint author), Kamuzu Cent Hosp, Lighthouse Ctr, POB 106, Lilongwe, Malawi. EM samphiri@lighthouse.org.mw RI Miller, William/H-4800-2014 OI Miller, William/0000-0002-1934-7827 FU UK Department for International Development through the Malawi National AIDS Commission; UNC at Chapel Hill, NC FX The study was funded by the UK Department for International Development through the Malawi National AIDS Commission and by grants from the UNC at Chapel Hill, NC. The views expressed are those of the authors and cannot be taken to reflect the official opinions of the Department for International Development or of the US CDC. NR 27 TC 9 Z9 9 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD DEC PY 2013 VL 40 IS 12 BP 923 EP 928 DI 10.1097/OLQ.0000000000000051 PG 6 WC Infectious Diseases SC Infectious Diseases GA 297GB UT WOS:000330242600005 PM 24220352 ER PT J AU Burgio, MR Ioannidis, JPA Kaminski, BM DeRycke, E Rogers, S Khoury, MJ Seminara, D AF Burgio, Michael R. Ioannidis, John P. A. Kaminski, Brett M. DeRycke, Eric Rogers, Scott Khoury, Muin J. Seminara, Daniela TI Collaborative Cancer Epidemiology in the 21st Century: The Model of Cancer Consortia SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Review ID GENOME-WIDE ASSOCIATION; BRCA2 MUTATION CARRIERS; BRAIN-TUMOR CONSORTIUM; PROSTATE-CANCER; BREAST-CANCER; GENETIC EPIDEMIOLOGY; FAMILY REGISTRY; INTERNATIONAL CONSORTIUM; COLON-CANCER; RISK AB During the last two decades, epidemiology has undergone a rapid evolution toward collaborative research. The proliferation of multi-institutional, interdisciplinary consortia has acquired particular prominence in cancer research. Herein, we describe the characteristics of a network of 49 established cancer epidemiology consortia (CEC) currently supported by the Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI). This collection represents the largest disease-based research network for collaborative cancer research established in population sciences. We describe the funding trends, geographic distribution, and areas of research focus. The CEC have been partially supported by 201 grants and yielded 3,876 publications between 1995 and 2011. We describe this output in terms of interdisciplinary collaboration and translational evolution. We discuss challenges and future opportunities in the establishment and conduct of large-scale team science within the framework of CEC, review future prospects for this approach to large-scale, interdisciplinary cancer research, and describe a model for the evolution of an integrated Network of Cancer Consortia optimally suited to address and support 21st-century epidemiology. (C)2013 AACR. C1 [Burgio, Michael R.; Kaminski, Brett M.; DeRycke, Eric; Rogers, Scott; Khoury, Muin J.; Seminara, Daniela] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Atlanta, GA USA. [Burgio, Michael R.] Sci Consulting Grp Inc, Gaithersburg, MD USA. [Ioannidis, John P. A.] Stanford Univ, Dept Med, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA. [Ioannidis, John P. A.] Stanford Univ, Sch Med, Dept Publ Hlth & Policy, Stanford, CA 94305 USA. [Ioannidis, John P. A.] Stanford Univ, Dept Stat, Sch Humanities & Sci, Stanford, CA 94305 USA. RP Burgio, MR (reprint author), NCI, NIH, Div Canc Control & Populat Sci, Epidemiol & Genom Res Program, 9609 Med Ctr Dr,Rm 4E320,MSC 9763, Rockville, MD 20850 USA. EM burgiom@mail.nih.gov FU Intramural CDC HHS [CC999999]; Intramural NIH HHS [Z99 CA999999] NR 64 TC 5 Z9 5 U1 0 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD DEC PY 2013 VL 22 IS 12 BP 2148 EP 2160 DI 10.1158/1055-9965.EPI-13-0591 PG 13 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 293ML UT WOS:000329975700002 PM 24045926 ER PT J AU Linton, YM Pecor, JE Porter, CH Mitchell, LB Garzon-Moreno, A Foley, DH Pecor, DB Wilkerson, RC AF Linton, Yvonne-Marie Pecor, James E. Porter, Charles H. Mitchell, Luke Brett Garzon-Moreno, Andres Foley, Desmond H. Pecor, David Brooks Wilkerson, Richard C. TI Mosquitoes of eastern Amazonian Ecuador: biodiversity, bionomics and barcodes SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Ecuador; Amazon; Culicidae; DNA barcodes; species list; habitat ID ALLIED TAXA DIPTERA; LIFE STAGES; NEOTYPE DESIGNATION; MORPHOLOGICAL DATA; AEDINI DIPTERA; SOUTH-AMERICA; CULICIDAE; ANOPHELES; CLASSIFICATION; PHYLOGENY AB Two snapshot surveys to establish the diversity and ecological preferences of mosquitoes (Diptera: Culicidae) in the terra firme primary rain forest surrounding the Tiputini Biodiversity Station in the UNESCO Yasun Biosphere Reserve of eastern Amazonian Ecuador were carried out in November 1998 and May 1999. The mosquito fauna of this region is poorly known; the focus of this study was to obtain high quality link-reared specimens that could be used to unequivocally confirm species level diversity through integrated systematic study of all life stages and DNA sequences. A total of 2,284 specimens were preserved; 1,671 specimens were link-reared with associated immature exuviae, all but 108 of which are slide mounted. This study identified 68 unique taxa belonging to 17 genera and 27 subgenera. Of these, 12 are new to science and 37 comprise new country records. DNA barcodes [ 658-bp of the mtDNA cytochrome c oxidase (COI) I gene] are presented for 58 individuals representing 20 species and nine genera. DNA barcoding proved useful in uncovering and confirming new species and we advocate an integrated systematics approach to biodiversity studies in future. Associated bionomics of all species collected are discussed. An updated systematic checklist of the mosquitoes of Ecuador (n = 179) is presented for the first time in 60 years. C1 [Linton, Yvonne-Marie; Pecor, James E.; Foley, Desmond H.; Pecor, David Brooks; Wilkerson, Richard C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Linton, Yvonne-Marie; Pecor, James E.; Mitchell, Luke Brett; Garzon-Moreno, Andres; Foley, Desmond H.; Pecor, David Brooks] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Porter, Charles H.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Wilkerson, Richard C.] Smithsonian Inst, Dept Entomol, Washington, DC 20560 USA. RP Linton, YM (reprint author), Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. EM linton.yvonne3@gmail.com OI Foley, Desmond/0000-0001-7525-4601 FU WRAIR; Smithsonian Institution; National Research Council Senior Associateship Award FX WRAIR and the Smithsonian Institution, National Research Council Senior Associateship Award (to YML), fieldwork supported by University of South Carolina (to RCW) NR 60 TC 11 Z9 11 U1 2 U2 13 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 EI 1678-8060 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD DEC PY 2013 VL 108 SU 1 BP 100 EP U132 DI 10.1590/0074-0276130440 PG 29 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 294ID UT WOS:000330037800014 PM 24473809 ER PT J AU Bailey, RL Gahche, JJ Thomas, PR Dwyer, JT AF Bailey, Regan L. Gahche, Jaime J. Thomas, Paul R. Dwyer, Johanna T. TI Why US children use dietary supplements SO PEDIATRIC RESEARCH LA English DT Article ID UNITED-STATES; NATIONAL-HEALTH; ADULTS; ADOLESCENTS; SAMPLE AB BACKGROUND: Dietary supplements are used by one-third of children. We examined motivations for supplement use in children, the types of products used by motivations, and the role of physicians and health care practitioners in guiding choices about supplements. METHODS: We examined motivations for dietary supplement use reported for children (from birth to 19 y of age; n = 8,245) using the National Health and Nutrition Examination Survey 2007-2010. RESULTS: Dietary supplements were used by 31% of children; many different reasons were given as follows: to "improve overall health" (41%), to "maintain health" (37%), for "supplementing the diet" (23%), to "prevent health problems" (20%), and to "boost immunity" (14%). Most children (similar to 90%) who use dietary supplements use a multivitamin-mineral or multivitamin product. Supplement users tend to be non-Hispanic white, have higher family incomes, report more physical activity, and have health insurance. Only a small group of supplements used by children (15%) were based on the recommendation of a physician or other health care provider. CONCLUSION: Most supplements used by children are not under the recommendation of a health care provider. The most common reasons for use of supplements in children are for health promotion, yet little scientific data support this notion in nutrient-replete children. C1 [Bailey, Regan L.; Thomas, Paul R.; Dwyer, Johanna T.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Gahche, Jaime J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Dwyer, Johanna T.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Dwyer, Johanna T.] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Dwyer, Johanna T.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA. RP Bailey, RL (reprint author), NIH, Off Dietary Supplements, Bldg 10, Bethesda, MD 20892 USA. EM baileyr@mail.nih.gov OI Dwyer, Johanna/0000-0002-0783-1769 FU Office of Dietary Supplements at the National Institutes of Health FX This work was supported in part by resources from the Office of Dietary Supplements at the National Institutes of Health. NR 14 TC 8 Z9 8 U1 3 U2 9 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0031-3998 EI 1530-0447 J9 PEDIATR RES JI Pediatr. Res. PD DEC PY 2013 VL 74 IS 6 BP 737 EP 741 DI 10.1038/pr.2013.160 PG 5 WC Pediatrics SC Pediatrics GA 287RN UT WOS:000329560000016 PM 24002333 ER PT J AU Wang, DX Krilich, J Pellett, S Baudys, J Tepp, WH Barr, JR Johnson, EA Kalb, SR AF Wang, Dongxia Krilich, Joan Pellett, Sabine Baudys, Jakub Tepp, William H. Barr, John R. Johnson, Eric A. Kalb, Suzanne R. TI Comparison of the catalytic properties of the botulinum neurotoxin subtypes A1 and A5 SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article DE Botulinum neurotoxin; Mass spectrometry ID CLOSTRIDIUM-BOTULINUM; SEROTYPE-A; SUBSTRATE RECOGNITION; NEUROTRANSMITTER RELEASE; SNARE MOTIF; ENDOPEP-MS; SNAP-25; CLEAVAGE; PROTEOLYSIS; SEQUENCE AB Clostridium botulinum neurotoxins (BoNTs) cause the life-threatening disease botulism through the inhibition of neurotransmitter release by cleaving essential SNARE proteins. There are seven serologically distinctive types of BoNTs and many subtypes within a serotype have been identified. BoNT/A5 is a recently discovered subtype of type A botulinum neurotoxin which possesses a very high degree of sequence similarity and identity to the well-studied Al subtype. In the present study, we examined the endopeptidase activity of these two BoNT/A subtypes and our results revealed significant differences in substrate binding and cleavage efficiency between subtype AS and Al. Distinctive hydrolysis efficiency was observed between the two toxins during cleavage of the native substrate SNAP-25 versus a shortened peptide mimic. N-terminal truncation studies demonstrated that a key region of the SNAP-25, including the amino acid residues at 151 through 154 located in the remote binding region of the substrate, contributed to the differential catalytic properties between Al and A5. Elevated binding affinity of the peptide substrate resulted from including these important residues and enhanced BoNT/ A5's hydrolysis efficiency. In addition, mutations of these amino add residues affect the proteolytic performance of the two toxins in different ways. This study provides a better understanding of the biological activity of these toxins, their performance characteristics in the Endopep-MS assay to detect BoNT in clinical samples and foods, and is useful for the development of peptide substrates. (C) 2013 The Authors. All rights reserved. C1 [Wang, Dongxia; Krilich, Joan; Baudys, Jakub; Barr, John R.; Kalb, Suzanne R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Pellett, Sabine; Tepp, William H.; Johnson, Eric A.] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA. RP Kalb, SR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. EM SKalb@cdc.gov FU Intramural CDC HHS [CC999999] NR 36 TC 9 Z9 9 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 EI 0006-3002 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD DEC PY 2013 VL 1834 IS 12 BP 2722 EP 2728 DI 10.1016/j.bbapap2013.09.007 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 285TQ UT WOS:000329418300030 PM 24096023 ER PT J AU Jefferds, ME Irizarry, L Timmer, A Tripp, K AF Jefferds, Maria Elena Irizarry, Laura Timmer, Arnold Tripp, Katie TI UNICEF-CDC global assessment of home fortification interventions 2011: Current status, new directions, and implications for policy and programmatic guidance SO FOOD AND NUTRITION BULLETIN LA English DT Article DE Complementary food supplement; home fortification; intervention; lipid-based nutrient supplement; micronutrient powders; program guidance ID FORMATIVE RESEARCH; SUSTAINABILITY; SPRINKLES; ANEMIA AB Background. Micronutrient powders (MNP) reduce anemia and improve iron status in children aged 6 to 23 months. Little is known about home fortification interventions in low-income and middle-income countries. Objective. To describe highlights of the Global Assessment of Home Fortification Interventions 2011, new directions, and needed policy and programmatic guidance. Methods. A cross-sectional survey of home fortification interventions was conducted. Staff at UNICEF and regional focal points at Home Fortification Technical Advisory Group partner agencies sent questionnaires to representatives in 152 low-income and middle-income countries. Included interventions met the following criteria: they were for prevention and used MNP, lipid-based nutrient supplements (LNS), or complementary food supplements (CFS); one recommended mode of use was mixing into food; they were implemented or planning to start within 12 months; and research interventions were directly linked to programs. Results. This study identified 63 implemented interventions (36 countries) and 28 planned interventions (21 countries), including 34 implemented interventions (22 countries) and 25 planned interventions (20 countries) that used MNR These interventions were expected to reach 17.2 million people in 2011, including 14.1 million participants in MNP interventions. Among implemented interventions, 16% distributed nationally. Most interventions used integrated approaches targeting young children. Recently, there was increasing expansion of interventions in Africa. The main challenges identified were monitoring and evaluation, adherence, product funding, and procurement. Conclusions. Home fortification interventions, especially those that use MNP, are increasing and scaling up rapidly in regions with widespread problems of micronutrient deficiencies and stunting. Home fortification interventions contribute to global initiatives to reduce undernutrition. C1 [Jefferds, Maria Elena; Tripp, Katie] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Irizarry, Laura; Timmer, Arnold] UNICEF, New York, NY USA. RP Jefferds, ME (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy MS-F-77, Atlanta, GA 30341 USA. EM mjefferds@cdc.gov FU Intramural CDC HHS [CC999999] NR 20 TC 9 Z9 9 U1 0 U2 6 PU INT NUTRITION FOUNDATION PI BOSTON PA 150 HARRISON AVE, BOSTON, MA 02111 USA SN 0379-5721 EI 1564-8265 J9 FOOD NUTR BULL JI Food Nutr. Bull. PD DEC PY 2013 VL 34 IS 4 BP 434 EP 443 PG 10 WC Food Science & Technology; Nutrition & Dietetics SC Food Science & Technology; Nutrition & Dietetics GA 287QA UT WOS:000329556100009 PM 24605694 ER PT J AU Rowhani-Rahbar, A Fireman, B Lewis, E Nordin, J Naleway, A Jacobsen, SJ Jackson, LA Tse, A Belongia, EA Hambidge, SJ Weintraub, E Baxter, R Klein, NP AF Rowhani-Rahbar, Ali Fireman, Bruce Lewis, Edwin Nordin, James Naleway, Allison Jacobsen, Steven J. Jackson, Lisa A. Tse, Alison Belongia, Edward A. Hambidge, Simon J. Weintraub, Eric Baxter, Roger Klein, Nicola P. TI Effect of Age on the Risk of Fever and Seizures Following Immunization With Measles-Containing Vaccines in Children SO JAMA PEDIATRICS LA English DT Article ID SAFETY DATALINK PROJECT; FEBRILE SEIZURES; VARICELLA VACCINE; ADVERSE EVENTS; COMBINATION MEASLES; ACTIVE SURVEILLANCE; RUBELLA VACCINE; MUMPS; IMMUNOGENICITY; PERTUSSIS AB IMPORTANCE The first dose of live attenuated measles-containing vaccines is associated with an increased risk of febrile seizures 7 to 10 days following immunization among 12-to 23-month-old children. The combination measles, mumps, rubella, and varicella vaccine is associated with a 2-fold increased risk of febrile seizures 7 to 10 days following immunization compared with the separately administered measles, mumps, and rubella and varicella vaccines. It is unknown whether the magnitude of these increased risks depends on age at immunization. OBJECTIVE To examine the potential modifying effect of age on the risk of fever and seizures following immunization with measles-containing vaccines. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study at 8 Vaccine Safety Datalink sites of a total of 840 348 children 12 to 23 months of age who had received a measles-containing vaccine from 2001 through 2011. EXPOSURES Any measles-containing vaccines and measles-containing vaccines by type. MAIN OUTCOMES AND MEASURES Fever and seizure events occurring during a 42-day postimmunization observation period. RESULTS In the analysis of any measles-containing vaccines, the increased risk of seizures during the 7-to 10-day risk interval, using the remainder of the observation period as the control interval, was significantly greater among older children (relative risk, 6.5; 95% CI, 5.3-8.1; attributable risk, 9.5 excess cases per 10 000 doses; 95% CI, 7.6-11.5) than among younger children (relative risk, 3.4; 95% CI, 3.0-3.9; attributable risk = 4.0 excess cases per 10 000 doses; 95% CI, 3.4-4.6). The relative risk of postimmunization fever was significantly greater among older children than among younger children; however, its attributable risk was not. In the analysis of vaccine type, measles, mumps, rubella, and varicella vaccine was associated with a 1.4-fold increase in the risk of fever and 2-fold increase in the risk of seizures compared with measles, mumps, and rubella vaccine administered with or without varicella vaccine in both younger and older children. CONCLUSIONS AND RELEVANCE Measles-containing vaccines are associated with a lower increased risk of seizures when administered at 12 to 15 months of age. Findings of this study that focused on safety outcomes highlight the importance of timely immunization of children with the first dose of measles-containing vaccines. C1 [Rowhani-Rahbar, Ali; Fireman, Bruce; Lewis, Edwin; Baxter, Roger; Klein, Nicola P.] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Nordin, James] HealthPartners Inst Educ & Res, Minneapolis, MN USA. [Naleway, Allison] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Jacobsen, Steven J.] Kaiser Permanente Dept Res & Evaluat, Pasadena, CA USA. [Jackson, Lisa A.] Grp Hlth Res Inst, Seattle, WA USA. [Tse, Alison] Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA. [Belongia, Edward A.] Marshfield Clin Res Fdn, Marshfield, WI USA. [Hambidge, Simon J.] Kaiser Permanente Inst Hlth Res, Denver, CO USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. RP Rowhani-Rahbar, A (reprint author), Univ Washington, Dept Epidemiol, POB 357236, Seattle, WA 98195 USA. EM rowhani@uw.edu OI Naleway, Allison/0000-0001-5747-4643; Jacobsen, Steven/0000-0002-8174-8533 FU CDC-sponsored VSD through America's Health Insurance Plans [200-2002-00732] FX This study was supported by the CDC-sponsored VSD through a subcontract (200-2002-00732) with America's Health Insurance Plans. NR 28 TC 24 Z9 25 U1 2 U2 8 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD DEC PY 2013 VL 167 IS 12 BP 1111 EP 1117 DI 10.1001/jamapediatrics.2013.2745 PG 7 WC Pediatrics SC Pediatrics GA 291QY UT WOS:000329845300009 PM 24126936 ER PT J AU Anderson, WL Wiener, JM Khatutsky, G Armour, BS AF Anderson, Wayne L. Wiener, Joshua M. Khatutsky, Galina Armour, Brian S. TI Obesity and people with disabilities: The implications for health care expenditures SO OBESITY LA English DT Article ID BODY-MASS INDEX; RISK-FACTORS; US ADULTS; OVERWEIGHT; PREVALENCE; MORTALITY; TRENDS; UNDERWEIGHT AB Objective This study estimates additional average health care expenditures for overweight and obesity for adults with disabilities vs. without. Design and Methods Descriptive and multivariate methods were used to estimate additional health expenditures by service type, age group, and payer using 2004-2007 Medical Expenditure Panel Survey data. Results In 2007, 37% of community-dwelling Americans with disabilities were obese vs. 27% of the total population. People with disabilities had almost three times ($2,459) the additional average obesity cost of people without disabilities ($889). Prescription drug expenditures for obese people with disabilities were three times as high and outpatient expenditures were 74% higher. People with disabilities in the 45- to 64-year age group had the highest obesity expenditures. Medicare had the highest additional average obesity expenditures among payers. Among people with prescription drug expenditures, obese people with disabilities had nine times the prevalence of diabetes as normal weight people with disabilities. Overweight people with and without disabilities had lower expenditures than normal-weight people with and without disabilities. Conclusions Obesity results in substantial additional health care expenditures for people with disabilities. These additional expenditures pose a serious current and future problem, given the potential for higher obesity prevalence in the coming decade. C1 [Anderson, Wayne L.; Wiener, Joshua M.; Khatutsky, Galina] RTI Int, Aging Disabil & Long Term Care Program, Res Triangle Pk, NC USA. [Armour, Brian S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Anderson, WL (reprint author), RTI Int, Aging Disabil & Long Term Care Program, Res Triangle Pk, NC USA. EM wlanderson@rti.org FU Centers for Disease Control and Prevention (CDC) [200-2007-22644, 05] FX This study was supported by the Centers for Disease Control and Prevention (CDC) [Contract #200-2007-22644, Task #05]. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 39 TC 6 Z9 6 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD DEC PY 2013 VL 21 IS 12 BP E798 EP E804 DI 10.1002/oby.20531 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 288LT UT WOS:000329614200036 PM 23804319 ER PT J AU Mirabelli, MC Beavers, SF Chatterjee, AB Moorman, JE AF Mirabelli, Maria C. Beavers, Suzanne F. Chatterjee, Arjun B. Moorman, Jeanne E. TI Age at asthma onset and subsequent asthma outcomes among adults with active asthma SO RESPIRATORY MEDICINE LA English DT Article DE Asthma; Epidemiology; Prevalence; Respiratory health; Surveillance ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; LUNG-FUNCTION; ATHEROSCLEROSIS-RISK; UNITED-STATES; HEALTH; MORTALITY; SURVEILLANCE; COMMUNITIES; CHILDHOOD AB Introduction: Little is known about the extent to which the age at which asthma first began influences respiratory health later in life. We conducted these analyses to examine the relationship between age at asthma onset and subsequent asthma-related outcomes. Methods: We used data from 12,216 adults with asthma who participated in the 2010 Behavioral Risk Factor Surveillance System Asthma Call-back Survey to describe the distribution of age at asthma onset. Linear regression was used to estimate associations of age at asthma onset with asthma-related outcomes, including symptoms in the past 30 days and asthma-related emergency visits. Results: Asthma onset before age 16 was reported by an estimated 42% of adults with active asthma, including 14% with onset at 5-9 years of age who reported experiencing any asthma symptoms on 21% of days in the past month. Compared to this group, the percentage of days in the past month with any asthma symptoms was 14.8% higher (95% confidence interval (Cl): 5.4, 24.1) among those whose asthma onset occurred at <1 year. When age at onset occurred at 10 years or older there was little change in the prevalence of asthma-related emergency visits across age at onset categories. Conclusion: Age at asthma onset may affect subsequent asthma-related outcomes. Published by Elsevier Ltd. C1 [Mirabelli, Maria C.; Beavers, Suzanne F.; Moorman, Jeanne E.] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Chatterjee, Arjun B.] Wake Forest Sch Med, Dept Internal Med, Sect Pulm Crit Care Allergy & Immunol Dis, Winston Salem, NC 27157 USA. RP Mirabelli, MC (reprint author), Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, 4770 Buford Highway NE,Mailstop F-60, Atlanta, GA 30341 USA. EM zif7@cdc.gov OI Mirabelli, Maria/0000-0002-3540-0085 FU National Asthma Control Program in the Air Pollution and Respiratory Health Branch of the National Center for Environmental Health FX The Asthma Call-back Survey is funded by the National Asthma Control Program in the Air Pollution and Respiratory Health Branch of the National Center for Environmental Health. The Asthma Call-back Survey is jointly administered with the Office of Surveillance, Epidemiology and Laboratory Services, Division of Behavioral Surveillance; data collection is managed by BRFSS coordinators in each of the participating states, the District of Columbia, and Puerto Rico. NR 32 TC 6 Z9 6 U1 0 U2 3 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 EI 1532-3064 J9 RESP MED JI Respir. Med. PD DEC PY 2013 VL 107 IS 12 BP 1829 EP 1836 DI 10.1016/j.rmed.2013.09.022 PG 8 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 287RA UT WOS:000329558700003 PM 24139624 ER PT J AU Yanamala, N Kagan, VE Shvedova, AA AF Yanamala, Naveena Kagan, Valerian E. Shvedova, Anna A. TI Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells SO ADVANCED DRUG DELIVERY REVIEWS LA English DT Review DE Molecular interactions; Computational predictions; Nano-bio interactions; Inhibition of nano-mechanisms; Oxidative damage; Comparable sizes of nanoparticles ID WALLED CARBON NANOTUBES; HIV-1 PR INHIBITORS; GLUTATHIONE-S-TRANSFERASE; METALLOFULLERENOL GD-AT-C-82(OH)(22); DYNAMICS SIMULATION; ELECTRON TOMOGRAPHY; PROTEIN MACHINES; C-60 FULLERENES; LIPID-BILAYER; KCSA CHANNEL AB Over the past two decades, nanotechnology has emerged as a key player in various disciplines of science and technology. Some of the most exciting applications are in the field of biomedicine - for theranostics (for combined diagnostic and therapeutic purposes) as well as for exploration of biological systems. A detailed understanding of the molecular interactions between nanoparticles and biological nano-machinery - macromolecules, membranes, and intracellular organelles - is crucial for obtaining adequate information on mechanisms of action of nanomaterials as well as a perspective on the long term effects of these materials and their possible toxicological outcomes. This review focuses on the use of structure-based computational molecular modeling as a tool to understand and to predict the interactions between nanomaterials and nano-biosystems. We review major approaches and provide examples of computational analysis of the structural principles behind such interactions. A rationale on how nanopartides of different sizes, shape, structure and chemical properties can affect the organization and functions of nano-machinery of cells is also presented. Published by Elsevier B.V. C1 [Yanamala, Naveena; Shvedova, Anna A.] NIOSH, Pathol & Physiol Res Branch, CDC, Morgantown, WV 26505 USA. [Kagan, Valerian E.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA USA. [Shvedova, Anna A.] WVU, Dept Physiol & Pharmacol, Morgantown, WV USA. RP Shvedova, AA (reprint author), NIOSH, Pathol & Physiol Res Branch, CDC, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM ats1@cdc.gov RI Arumugam, Thirumagal/C-3408-2014 FU NIH [HL70755, U19AI068021]; NORA [3927ZKCY/3927ZJQP]; NTRC [32927ZJHF/3927ZKNL]; NIOSH [OH008282, 2927ZKCY] FX This work was supported by NIH (HL70755 and U19AI068021), NORA (3927ZKCY/3927ZJQP), NTRC (32927ZJHF/3927ZKNL), and NIOSH (OH008282 and 2927ZKCY) grants. NR 92 TC 17 Z9 18 U1 4 U2 91 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-409X EI 1872-8294 J9 ADV DRUG DELIVER REV JI Adv. Drug Deliv. Rev. PD DEC PY 2013 VL 65 IS 15 BP 2070 EP 2077 DI 10.1016/j.addr.2013.05.005 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 286OQ UT WOS:000329479000013 PM 23726945 ER PT J AU Espinel-Ingroff, A Arendrup, MC Pfaller, MA Bonfietti, LX Bustamante, B Canton, E Chryssanthou, E Cuenca-Estrella, M Dannaoui, E Fothergill, A Fuller, J Gaustad, P Gonzalez, GM Guarro, J Lass-Florl, C Lockhart, SR Meis, JF Moore, CB Ostrosky-Zeichner, L Pelaez, T Pukinskas, SRBS St-Germain, G Szeszs, MW Turnidge, J AF Espinel-Ingroff, A. Arendrup, M. C. Pfaller, M. A. Bonfietti, L. X. Bustamante, B. Canton, E. Chryssanthou, E. Cuenca-Estrella, M. Dannaoui, E. Fothergill, A. Fuller, J. Gaustad, P. Gonzalez, G. M. Guarro, J. Lass-Floerl, C. Lockhart, S. R. Meis, J. F. Moore, C. B. Ostrosky-Zeichner, L. Pelaez, T. Pukinskas, S. R. B. S. St-Germain, G. Szeszs, M. W. Turnidge, J. TI Interlaboratory Variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST Methods: Should the Clinical Laboratory Be Testing This Agent? SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID EPIDEMIOLOGIC CUTOFF VALUES; TECHNICAL NOTE; SUSCEPTIBILITY; DISTRIBUTIONS; INFECTION; SECONDARY; FUNGEMIA AB Although Clinical and Laboratory Standards Institute (CLSI) clinical breakpoints (CBPs) are available for interpreting echinocandin MICs for Candida spp., epidemiologic cutoff values (ECVs) based on collective MIC data from multiple laboratories have not been defined. While collating CLSI caspofungin MICs for 145 to 11,550 Candida isolates from 17 laboratories (Brazil, Canada, Europe, Mexico, Peru, and the United States), we observed an extraordinary amount of modal variability (wide ranges) among laboratories as well as truncated and bimodal MIC distributions. The species-specific modes across different laboratories ranged from 0.016 to 0.5 mu g/ml for C. albicans and C. tropicalis, 0.031 to 0.5 mu g/ml for C. glabrata, and 0.063 to 1 mu g/ml for C. krusei. Variability was also similar among MIC distributions for C. dubliniensis and C. lusitaniae. The exceptions were C. parapsilosis and C. guilliermondii MIC distributions, where most modes were within one 2-fold dilution of each other. These findings were consistent with available data from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) (403 to 2,556 MICs) for C. albicans, C. glabrata, C. krusei, and C. tropicalis. Although many factors (caspofungin powder source, stock solution solvent, powder storage time length and temperature, and MIC determination testing parameters) were examined as a potential cause of such unprecedented variability, a single specific cause was not identified. Therefore, it seems highly likely that the use of the CLSI species-specific caspofungin CBPs could lead to reporting an excessive number of wild-type (WT) isolates (e.g., C. glabrata and C. krusei) as either non-WT or resistant isolates. Until this problem is resolved, routine testing or reporting of CLSI caspofungin MICs for Candida is not recommended; micafungin or anidulafungin data could be used instead. C1 [Espinel-Ingroff, A.] Virginia Commonwealth Univ, Med Ctr, Richmond, VA 23284 USA. [Arendrup, M. C.] Statens Serum Inst, Dept Microbiol Surveillance & Res, Unit Mycol, DK-2300 Copenhagen, Denmark. [Pfaller, M. A.] JMI Labs, Iowa City, IA USA. [Pfaller, M. A.] Univ Iowa, Iowa City, IA USA. [Bonfietti, L. X.] Adolfo Lutz Inst, Aracatuba City, Brazil. [Bustamante, B.] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander von Humboldt, Lima, Peru. [Canton, E.] Hosp Univ La Fe, Ctr Invest, Unidad Microbiol Expt, Valencia, Spain. [Chryssanthou, E.] Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden. [Cuenca-Estrella, M.] Inst Salud Carlos III, Dept Mycol, Ctr Nacl Microbiol, Madrid, Spain. [Dannaoui, E.] Inst Pasteur, Ctr Natl Reference Mycoses & Antifong, Unite Mycol Mol, Paris, France. [Fothergill, A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Fuller, J.] Univ Alberta, Edmonton, AB, Canada. [Gaustad, P.] Aker Univ Hosp, Inst Med Microbiol, Rikshosp, Oslo, Norway. [Gonzalez, G. M.] Univ Autonoma Nuevo Leon, Monterrey, Nuevo Leon, Mexico. [Guarro, J.] URV, IISPV, Fac Med, Reus, Spain. [Lass-Floerl, C.] Med Univ Innsbruck, Div Hyg & Med Microbiol, A-6020 Innsbruck, Austria. [Lockhart, S. R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Meis, J. F.] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands. [Meis, J. F.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Moore, C. B.] Univ S Manchester Hosp, Mycol Reference Ctr, Educ & Res Ctr, Manchester M20 8LR, Lancs, England. [Ostrosky-Zeichner, L.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Pelaez, T.] Univ Complutense, Fac Med, Hosp Gen Univ Gregorio Maranon, E-28040 Madrid, Spain. [Pukinskas, S. R. B. S.] Adolfo Lutz Inst, Fungal Taxon Labs, Sao Paulo, Brazil. [St-Germain, G.] Inst Natl Sante Publ Quebec, Lab Sante Publ Quebec, Quebec City, PQ, Canada. [Szeszs, M. W.] Adolfo Lutz Inst, Dept Mycol, Sao Paulo, Brazil. [Turnidge, J.] Univ Adelaide, Adelaide, SA, Australia. RP Espinel-Ingroff, A (reprint author), Virginia Commonwealth Univ, Med Ctr, Richmond, VA 23284 USA. EM avingrof@vcu.edu OI Guarro, Josep/0000-0002-7839-7568 NR 22 TC 71 Z9 72 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2013 VL 57 IS 12 BP 5836 EP 5842 DI 10.1128/AAC.01519-13 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 279KW UT WOS:000328959900007 PM 24018263 ER PT J AU Ndao, M Nath-Chowdhury, M Sajid, M Marcus, V Mashiyama, ST Sakanari, J Chow, E Mackey, Z Land, KM Jacobson, MP Kalyanaraman, C McKerrow, JH Arrowood, MJ Caffrey, CR AF Ndao, Momar Nath-Chowdhury, Milli Sajid, Mohammed Marcus, Victoria Mashiyama, Susan T. Sakanari, Judy Chow, Eric Mackey, Zachary Land, Kirkwood M. Jacobson, Matthew P. Kalyanaraman, Chakrapani McKerrow, James H. Arrowood, Michael J. Caffrey, Conor R. TI A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID RANDOMIZED-CONTROLLED-TRIAL; PLASMODIUM-FALCIPARUM; PARASITIC DISEASES; TOXOPLASMA-GONDII; TRYPANOSOMA-CRUZI; ZAMBIAN CHILDREN; VINYL SULFONES; CELL INVASION; KNOCKOUT MICE; NITAZOXANIDE AB Cryptosporidiosis, caused by the protozoan parasite Cryptosporidium parvum, can stunt infant growth and can be lethal in immunocompromised individuals. The most widely used drugs for treating cryptosporidiosis are nitazoxanide and paromomycin, although both exhibit limited efficacy. To investigate an alternative approach to therapy, we demonstrate that the clan CA cysteine protease inhibitor N-methyl piperazine-Phe-homoPhe-vinylsulfone phenyl (K11777) inhibits C. parvum growth in mammalian cell lines in a concentration-dependent manner. Further, using the C57BL/6 gamma interferon receptor knockout (IFN-gamma R-KO) mouse model, which is highly susceptible to C. parvum, oral or intraperitoneal treatment with K11777 for 10 days rescued mice from otherwise lethal infections. Histologic examination of untreated mice showed intestinal inflammation, villous blunting, and abundant intracellular parasite stages. In contrast, K11777-treated mice (210 mg/kg of body weight/day) showed only minimal inflammation and no epithelial changes. Three putative protease targets (termed cryptopains 1 to 3, or CpaCATL-1, -2, and -3) were identified in the C. parvum genome, but only two are transcribed in infected mammals. A homology model predicted that K11777 would bind to cryptopain 1. Recombinant enzymatically active cryptopain 1 was successfully targeted by K11777 in a competition assay with a labeled active-site-directed probe. K11777 exhibited no toxicity in vitro and in vivo, and surviving animals remained free of parasites 3 weeks after treatment. The discovery that a cysteine protease inhibitor provides potent anticryptosporidial activity in an animal model of infection encourages the investigation and development of this biocide class as a new, and urgently needed, chemotherapy for cryptosporidiosis. C1 [Ndao, Momar; Nath-Chowdhury, Milli] McGill Univ, Res Inst, Natl Reference Ctr Parasitol, Ctr Hlth, Montreal, PQ, Canada. [Sajid, Mohammed; Sakanari, Judy; Chow, Eric; Mackey, Zachary; Land, Kirkwood M.; McKerrow, James H.; Caffrey, Conor R.] Univ Calif San Francisco, Ctr Discovery & Innovat Parasit Dis, San Francisco, CA 94143 USA. [Sajid, Mohammed; Sakanari, Judy; Chow, Eric; Mackey, Zachary; Land, Kirkwood M.; McKerrow, James H.; Caffrey, Conor R.] Univ Calif San Francisco, Dept Pathol, Calif Inst Quantitat Biosci, San Francisco, CA 94140 USA. [Sajid, Mohammed] Leiden Univ, Med Ctr, Leiden, Netherlands. [Marcus, Victoria] McGill Univ, Montreal Gen Hosp, Ctr Hlth, Dept Pathol, Montreal, PQ H3G 1A4, Canada. [Land, Kirkwood M.] Univ Pacific, Dept Biol Sci, Stockton, CA 95211 USA. [Jacobson, Matthew P.; Kalyanaraman, Chakrapani] Univ Calif San Francisco, Dept Pharmaceut Sci, San Francisco, CA 94143 USA. [Mashiyama, Susan T.; Jacobson, Matthew P.; Kalyanaraman, Chakrapani] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA. [Arrowood, Michael J.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. RP Ndao, M (reprint author), McGill Univ, Res Inst, Natl Reference Ctr Parasitol, Ctr Hlth, Montreal, PQ, Canada. EM momar.ndao@mcgill.ca OI Jacobson, Matthew/0000-0001-6262-655X FU Sandler Foundation; Foundation of the Montreal General Hospital; Research Institute of the McGill University Health Centre; PhRMA Foundation FX The study was supported by the Sandler Foundation, the Foundation of the Montreal General Hospital, and the Research Institute of the McGill University Health Centre. Additional support was provided by the PhRMA Foundation (a Postdoctoral Fellowship in Informatics to S. T. M.). NR 74 TC 11 Z9 11 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2013 VL 57 IS 12 BP 6063 EP 6073 DI 10.1128/AAC.00734-13 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 279KW UT WOS:000328959900031 PM 24060869 ER PT J AU Tamura, D Nguyen, HT Sleeman, K Levine, M Mishin, VP Yang, H Guo, Z Okomo-Adhiambo, M Xu, XY Stevens, J Gubareva, LV AF Tamura, Daisuke Nguyen, Ha T. Sleeman, Katrina Levine, Marnie Mishin, Vasiliy P. Yang, Hua Guo, Zhu Okomo-Adhiambo, Margaret Xu, Xiyan Stevens, James Gubareva, Larisa V. TI Cell Culture-Selected Substitutions in Influenza A(H3N2) Neuraminidase Affect Drug Susceptibility Assessment SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID RECEPTOR-BINDING VARIANTS; CANINE KIDNEY-CELLS; SIALIC-ACID; MDCK CELLS; A VIRUSES; LINE VERO; B VIRUSES; RESISTANCE; REPLICATION; INHIBITORS AB Assessment of drug susceptibility has become an integral part of influenza virus surveillance. In this study, we describe the drug resistance profile of influenza A(H3N2) virus, A/Mississippi/05/2011, collected from a patient treated with oseltamivir and detected via surveillance. An MDCK cell-grown isolate of this virus exhibited highly reduced inhibition by the neuraminidase (NA) inhibitors (NAIs) oseltamivir (8,005-fold), zanamivir (813-fold), peramivir (116-fold), and laninamivir (257-fold) in the NA inhibition assay. Sequence analysis of its NA gene revealed a known oseltamivir-resistance marker, the glutamic acid-to-valine substitution at position 119 (E119V), and an additional change, threonine to isoleucine at position 148 (T148I). Unlike E119V, T148I was not detected in the clinical sample but acquired during viral propagation in MDCK cells. Using recombinant proteins, T148I by itself was shown to cause only a 6-fold increase in the zanamivir 50% inhibitory concentration (IC50) and had no effect on inhibition by other drugs. The T148I substitution reduced NA activity by 50%, most likely by affecting the positioning of the 150 loop at the NA catalytic site. Using pyrosequencing, changes at T148 were detected in 35 (23%) of 150 MDCK cell-grown A(H3N2) viruses tested, which was lower than the frequency of changes at D151 (85%), an NA residue previously implicated in cell selection. We demonstrate that culturing of the A(H3N2) viruses (n = 11) at a low multiplicity of infection delayed the emergence of the NA variants with changes at position 148 and/or 151, especially when conducted in MDCK-SIAT1 cells. Our findings highlight the current challenges in monitoring susceptibility of influenza A(H3N2) viruses to the NAI class of antiviral drugs. C1 [Tamura, Daisuke; Nguyen, Ha T.; Sleeman, Katrina; Levine, Marnie; Mishin, Vasiliy P.; Yang, Hua; Guo, Zhu; Okomo-Adhiambo, Margaret; Xu, Xiyan; Stevens, James; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Virus Surveillance & Diag Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Tamura, Daisuke] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Nguyen, Ha T.; Levine, Marnie] Battelle Mem Inst, Atlanta, GA USA. RP Gubareva, LV (reprint author), Ctr Dis Control & Prevent, Virus Surveillance & Diag Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM lqg3@cdc.gov FU Centers for Disease Control and Prevention; Oak Ridge Institute for Science and Education (ORISE) (Oak Ridge, TN); Business of Innovation (Battelle, Atlanta, GA) FX This work was supported by the Centers for Disease Control and Prevention. Financial support for D. T. for this study was provided by the Oak Ridge Institute for Science and Education (ORISE) (Oak Ridge, TN). H.T.N. and M. L. received financial support for this work from the Business of Innovation (Battelle, Atlanta, GA). NR 35 TC 13 Z9 13 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2013 VL 57 IS 12 BP 6141 EP 6146 DI 10.1128/AAC.01364-13 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 279KW UT WOS:000328959900040 PM 24080660 ER PT J AU Mucker, EM Goff, AJ Shamblin, JD Grosenbach, DW Damon, IK Mehal, JM Holman, RC Carroll, D Gallardo, N Olson, VA Clemmons, CJ Hudson, P Hruby, DE AF Mucker, Eric M. Goff, Arthur J. Shamblin, Joshua D. Grosenbach, Douglas W. Damon, Inger K. Mehal, Jason M. Holman, Robert C. Carroll, Darin Gallardo, Nadia Olson, Victoria A. Clemmons, Cody J. Hudson, Paul Hruby, Dennis E. TI Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox) SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID EXTRACELLULAR ENVELOPED VIRUS; ANTIPOXVIRUS COMPOUND ST-246; VACCINIA VIRUS; HUMAN VOLUNTEERS; VACCINATION; MODEL; MICE; DISSEMINATION; CHALLENGE; RESPONSES AB Naturally occurring smallpox has been eradicated but remains a considerable threat as a biowarfare/bioterrorist weapon (F. Fleck, Bull. World Health Organ. 81: 917-918, 2003). While effective, the smallpox vaccine is currently not recommended for routine use in the general public due to safety concerns (http://www.bt.cdc.gov/agent/smallpox/vaccination). Safe and effective countermeasures, particularly those effective after exposure to smallpox, are needed. Currently, SIGA Technologies is developing the small-molecule oral drug, tecovirimat (previously known as ST-246), as a postexposure therapeutic treatment of orthopoxvirus disease, including smallpox. Tecovirimat has been shown to be efficacious in preventing lethal orthopoxviral disease in numerous animal models (G. Yang, D. C. Pevear, M. H. Davies, M. S. Collett, T. Bailey, et al., J. Virol. 79: 13139-13149, 2005; D. C. Quenelle, R. M. Buller, S. Parker, K. A. Keith, D. E. Hruby, et al., Antimicrob. Agents Chemother., 51: 689-695, 2007; E. Sbrana, R. Jordan, D. E. Hruby, R. I. Mateo, S. Y. Xiao, et al., Am. J. Trop. Med. Hyg. 76: 768 -773, 2007). Furthermore, in clinical trials thus far, the drug appears to be safe, with a good pharmacokinetic profile. In this study, the efficacy of tecovirimat was evaluated in both a prelesional and postlesional setting in nonhuman primates challenged intravenously with 1 x 10(8) PFU of Variola virus (VARV; the causative agent of smallpox), a model for smallpox disease in humans. Following challenge, 50% of placebo-treated controls succumbed to infection, while all tecovirimat-treated animals survived regardless of whether treatment was started at 2 or 4 days postinfection. In addition, tecovirimat treatment resulted in dramatic reductions in dermal lesion counts, oropharyngeal virus shedding, and viral DNA circulating in the blood. Although clinical disease was evident in tecovirimat- treated animals, it was generally very mild and appeared to resolve earlier than in placebo-treated controls that survived infection. Tecovirimat appears to be an effective smallpox therapeutic in nonhuman primates, suggesting that it is reasonably likely to provide therapeutic benefit in smallpox-infected humans. C1 [Mucker, Eric M.; Goff, Arthur J.; Shamblin, Joshua D.] USAMRIID, Frederick, MD USA. [Grosenbach, Douglas W.; Hruby, Dennis E.] SIGA Technol Inc, Corvallis, OR USA. [Damon, Inger K.; Carroll, Darin; Gallardo, Nadia; Olson, Victoria A.; Clemmons, Cody J.; Hudson, Paul] Ctr Dis Control & Prevent CDC, Poxvirus & Rabies Branch, Atlanta, GA USA. [Mehal, Jason M.; Holman, Robert C.] CDC, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. RP Hruby, DE (reprint author), SIGA Technol Inc, Corvallis, OR USA. EM dhruby@siga.com FU Defense Threat Reduction Agency (DTRA) FX The work described herein was supported by the Defense Threat Reduction Agency (DTRA). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 34 TC 8 Z9 9 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2013 VL 57 IS 12 BP 6246 EP 6253 DI 10.1128/AAC.00977-13 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 279KW UT WOS:000328959900053 PM 24100494 ER PT J AU Yu, SF Nakata, A Gu, GZ Swanson, NG Zhou, WH He, LH Wang, S AF Yu Shan Fa Nakata, Akinori Gu Gui Zhen Swanson, Naomi G. Zhou Wen Hui He Li Hua Wang Sheng TI Co-effect of Demand-control-support Model and Effort-reward Imbalance Model on Depression Risk Estimation in Humans: Findings from Henan Province of China SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES LA English DT Article DE Depression; Work-related stress; Demand-control-support; Effort-reward imbalance ID PSYCHOSOCIAL WORK-ENVIRONMENT; JOB-STRESS MODELS; COLLAR WORKERS; MENTAL-HEALTH; SOCIAL-CLASS; SYMPTOMS; COMPLEMENTARY; EMPLOYEES; STRAIN; ASSOCIATION AB Objective To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively. Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire (Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale (CES-D). Results DC (demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support (SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone. ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively. Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans. C1 [Yu Shan Fa; Gu Gui Zhen; Zhou Wen Hui] Henan Prov Inst Occupat Hlth, Zhengzhou 450052, Henan, Peoples R China. [Nakata, Akinori; Swanson, Naomi G.] NIOSH, Cincinnati, OH 45226 USA. [He Li Hua; Wang Sheng] Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China. RP Yu, SF (reprint author), Henan Prov Inst Occupat Hlth, Zhengzhou 450052, Henan, Peoples R China. EM chinas-tress@sina.com FU Henan Provincial Health Science and Technology Key Projects [201001009]; National Science and Technology Infrastructure Program, China [2006BA I06B 08] FX This research was funded by Henan Provincial Health Science and Technology Key Projects (201001009) and National Science and Technology Infrastructure Program (2006BA I06B 08), China. NR 39 TC 4 Z9 9 U1 0 U2 16 PU CHINESE CENTER DISEASE CONTROL & PREVENTION PI BEIJING PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA SN 0895-3988 J9 BIOMED ENVIRON SCI JI Biomed. Environ. Sci. PD DEC PY 2013 VL 26 IS 12 BP 962 EP 971 DI 10.3967/bes2013.031 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 286PB UT WOS:000329480100004 PM 24393505 ER PT J AU Meites, E AF Meites, Elissa TI Trichomoniasis The "Neglected" Sexually Transmitted Disease SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Article DE Trichomonas vaginalis; Vaginitis; Urethritis; Nucleic acid amplification tests; Nitroimidazoles; Sexually transmitted disease ID HUMAN-IMMUNODEFICIENCY-VIRUS; RANDOMIZED CONTROLLED-TRIAL; VAGINALIS INFECTION; UNITED-STATES; CHLAMYDIA-TRACHOMATIS; AMPLIFICATION ASSAY; PROSTATE-CANCER; WET PREPARATION; CLINICAL-TRIAL; AFRICAN WOMEN AB Trichomonas vaginalis is the most prevalent nonviral sexually transmitted infection, affecting an estimated 3.7 million people in the United States. Although trichomoniasis is common, it has been considered a "neglected" sexually transmitted disease, due to limited knowledge of its sequelae and associated costs. This article reviews current epidemiology, pathophysiology, diagnostic methods, clinical management recommendations and special considerations, research on associated conditions and costs, prevention strategies, and controversies regarding trichomoniasis. C1 Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP Meites, E (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd Northeast,MS E-02, Atlanta, GA 30333 USA. EM emeites@cdc.gov OI Meites, Elissa/0000-0002-0077-2591 FU Intramural CDC HHS [CC999999] NR 53 TC 8 Z9 8 U1 0 U2 12 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 EI 1557-9824 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD DEC PY 2013 VL 27 IS 4 BP 755 EP + DI 10.1016/j.idc.2013.06.003 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 281FW UT WOS:000329086400005 PM 24275268 ER PT J AU Dunne, EF Park, IU AF Dunne, Eileen F. Park, Ina U. TI HPV and HPV-Associated Diseases SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Article DE HPV; Anogenital warts; Genital warts; HPV-associated diseases; Cervical cancer; HPV vaccines ID HUMAN-PAPILLOMAVIRUS INFECTION; GENITAL HUMAN-PAPILLOMAVIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; AGE-SPECIFIC PREVALENCE; UNITED-STATES; YOUNG-WOMEN; NATURAL-HISTORY; HETEROSEXUAL COUPLES; ANAL CANCER; VACCINATION COVERAGE AB Human papillomavirus (HPV) is the most common sexually transmitted infection. HPV is associated with a significant burden of disease and cancer, including anogenital warts and recurrent respiratory papillomatosis, and anogenital and oropharyngeal cancers. Effective prevention is available, including primary prevention of cancers and anogenital warts through HPV vaccination, and secondary prevention of cervical cancer through screening and treatment of precancer. This article focuses on HPV infection and the clinical consequences of infection, with attention to cervical and anogenital squamous intraepithelial neoplasia and anogenital warts. C1 [Dunne, Eileen F.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30030 USA. [Park, Ina U.] Univ Calif San Francisco, Sch Med, Dept Family & Community Med, San Francisco, CA 94110 USA. [Park, Ina U.] Calif STD HIV Prevent Training Ctr, Oakland, CA 94612 USA. RP Dunne, EF (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30030 USA. EM Dde9@cdc.gov NR 62 TC 19 Z9 20 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 EI 1557-9824 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD DEC PY 2013 VL 27 IS 4 BP 765 EP + DI 10.1016/j.idc.2013.09.001 PG 15 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 281FW UT WOS:000329086400006 PM 24275269 ER PT J AU Miko, A Delannoy, S Fach, P Strockbine, NA Lindstedt, BA Mariani-Kurkdjian, P Reetz, J Beutin, L AF Miko, Angelika Delannoy, Sabine Fach, Patrick Strockbine, Nancy A. Lindstedt, Bjorn Arne Mariani-Kurkdjian, Patricia Reetz, Jochen Beutin, Lothar TI Genotypes and virulence characteristics of Shiga toxin-producing Escherichia coli 0104 strains from different origins and sources SO INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article DE E. coli 0104; Shiga-toxins; Enteroaggregative E. coli; Virulence; Genotyping; PFGE; Real time PCR; Cell-adhesion ID HEMOLYTIC-UREMIC SYNDROME; ANTIGEN GENE-CLUSTER; REAL-TIME PCR; O104/H4 STRAINS; OUTBREAK STRAIN; STEC STRAINS; GERMANY; SEQUENCE; PATHOGENICITY; EXPRESSION AB Sixty-two Escherichia colt strains carrying the wzx(O104)-gene from different sources, origins and time periods were analyzed for their serotypes, virulence genes and compared for genomic similarity by pulsed-field gel-electrophoresis (PFGE). The 0104 antigen was present in 55 strains and the structurally and genetically related capsular antigen K9 in five strains. The presence of 49 genes associated with enteropathogenic E. coli (EPEC), enteroaggregative E. colt (EAEC) and enterohemorrhagic E. colt (EHEC) was investigated. Fifty-four strains of serotypes 0104:H2 (n = 1), 0104:H4 (n =37), 0104:H7 (n =5) and 0104:H21 (n = 11) produced Shiga-toxins (Stx). Among STEC 0104, a close association between serotype, virulence gene profile and genomic similarity was found. EAEC virulence genes were only present in STEC 0104:H4 strains. EHEC-0157 plasmid-encoded genes were only found in STEC 0104:H2, 0104:H7 and 0104:H21 strains. None of the 62 0104 or 1(9 strains carried an eae-gene involved in the attaching and effacing phenotype. The 38 0104:H4 strains formed a single PFGE-cluster (>83.7% similarity). Thirty-one of these strains were from the European 0104:H4 outbreak in 2011. The outbreak strains and older 0104:H4 strains from Germany (2001), Georgia and France (2009) clustered together at >86.2% similarity. 0104:H4 strains isolated between 2001 and 2009 differed for some plasmid-encoded virulence genes compared to the outbreak strains from 2011. STEC 0104:H21 and STEC 0104:H7 strains isolated in the U.S. and in Europe showed characteristic differences in their Stx-types, virulence gene and PFGE profiles indicating that these have evolved separately. E. colt 1(9 strains were not associated with virulence and were-heterogeneous for their serotypes and PFGE profiles. (C) 2013 Elsevier GmbH. All rights reserved. C1 [Miko, Angelika; Reetz, Jochen; Beutin, Lothar] Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany. [Delannoy, Sabine; Fach, Patrick] Anses French Agcy Food Environm & Occupat Hlth &, Food Safety Lab, Maisons Alfort, France. [Strockbine, Nancy A.] Ctr Dis Control & Prevent, Escherichia & Shigella Reference Unit, Atlanta, GA USA. [Lindstedt, Bjorn Arne] Norwegian Inst Publ Hlth, Dept Foodborne Infect, Oslo, Norway. [Mariani-Kurkdjian, Patricia] Hop Robert Debre, AP HP, Ctr Natl Reference Escherichia Coli & Shigella, Microbiol Serv,Lab Associe, F-75019 Paris, France. RP Beutin, L (reprint author), BfR Fed Inst Risk Assessment, Natl Reference Lab Escherichia Coli, Diedersdorfer Weg 1, D-12277 Berlin, Germany. EM lothar.beutin@bfr.bund.de FU food inspection labs in Germany FX The authors are grateful to Denis Pierard, Brussels, Belgium, Sabine Schlager, Graz, Austria, Alex Gill, Ottawa, Canada, Wolfgang Witte, Wernigerode, Germany, Sascha Al-Dahouk, Berlin, Germany, Stefan Zimmermann, Berlin, Germany, Dietrich Made, Magdeburg, Germany, Detlef Horn, Krefeld, Germany; Hella Monse, Krefeld, Germany, Andrea Moss, Oldenburg, Germany and Estelle Loukiades, Lyon, France, for providing E. coli 0104 strains for the study. We thank Karin Pries, Katja Steege, Ylanna Burgos, Sabine Haby, Nadine Albrecht and Maria Margarida Vargas for excellent technical assistance and the colleagues from the BfR outbreak investigation team as well as from the food inspection labs in Germany for their active support. NR 66 TC 13 Z9 14 U1 2 U2 14 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1438-4221 EI 1618-0607 J9 INT J MED MICROBIOL JI Int. J. Med. Microbiol. PD DEC PY 2013 VL 303 IS 8 BP 410 EP 421 DI 10.1016/j.ijmm.2013.05.006 PG 12 WC Microbiology; Virology SC Microbiology; Virology GA 277HQ UT WOS:000328810000002 PM 23777812 ER PT J AU Bhat, G Naumann, RB AF Bhat, Geeta Naumann, Rebecca B. TI Travel-related behaviors, opinions, and concerns of US adult drivers by race/ethnicity, 2010 SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE Travel behaviors; Transportation; Race; Ethnicity ID DRIVING CESSATION; OLDER-ADULTS AB Introduction: The U.S. population is shifting to become both older and more racially and ethnically diverse. Our current understanding of U.S. drivers' travel-related needs and concerns by race/ethnicity is limited. Methods: Data from the 2010 HealthStyles survey, an annual, cross-sectional, national mail-panel survey of persons ages 18 years or older living in the United States, were used to calculate weighted percentages of travel-related behaviors, opinions, and concerns by race/ethnicity. Logistic regression was used to explore associations between race/ethnicity and specific travel-related concerns, while adjusting for other demographic characteristics. Results: Adequate transportation alternatives to driving were reported by a greater percentage of persons in certain minority groups compared to whites (Hispanic: 34.7%; white: 23.4%). Concern for the availability of alternatives to driving in the future was greater among minority groups (black: 57.7%; Hispanic: 473%; other: 50.9%) compared to whites (37.5%). Additionally, among persons with a household income of $25,000 +, minorities were generally more likely than whites to report concern about having alternative transportation options to driving, whereas concern was consistently high among all racial/ethnic groups for those earning less than $25,000 annually. In each racial/ethnic group, more than 10% of persons reported not knowing how they would get around if they could no longer drive. Conclusions: Important variations by race/ethnicity in both travel behaviors and concerns for adequate alternatives to driving were found, revealing the need for further research to better understand reasons for these differences and to identify ways to meet the transportation needs of the changing U.S. population demographics. Impact on Industry: Further research on adequate alternatives to driving and transportation needs is needed. (C) 2013 National Safety Council and Elsevier Ltd. All rights reserved. C1 [Bhat, Geeta; Naumann, Rebecca B.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30096 USA. RP Bhat, G (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,MS F-62, Atlanta, GA 30341 USA. EM GBhat@cdc.gov NR 16 TC 2 Z9 2 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 EI 1879-1247 J9 J SAFETY RES JI J. Saf. Res. PD DEC PY 2013 VL 47 BP 93 EP 97 DI 10.1016/j.jsr.2013.09.001 PG 5 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 285UV UT WOS:000329421400012 PM 24237875 ER PT J AU Pan, LP May, AL Wethington, H Dalenius, K Grummer-Strawn, LM AF Pan, Liping May, Ashleigh L. Wethington, Holly Dalenius, Karen Grummer-Strawn, Laurence M. TI Incidence of Obesity Among Young US Children Living in Low-Income Families, 2008-2011 SO PEDIATRICS LA English DT Article DE childhood obesity; incidence; preschool age; infancy; population-based studies; public health ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; CHILDHOOD OBESITY; UNITED-STATES; ADOLESCENT OVERWEIGHT; PREVALENCE; TRENDS AB OBJECTIVE: To examine the incidence and reverse of obesity among young low-income children and variations across population subgroups. METHODS: We included 1.2 million participants in federally funded child health and nutrition programs who were 0 to 23 months old in 2008 and were followed up 24 to 35 months later in 2010-2011. Weight and height were measured. Obesity at baseline was defined as gender-specific weight-for-length >= 95th percentile on the 2000 Centers for Disease Control and Prevention growth charts. Obesity at follow-up was defined as gender-specific BMI-for-age >= 95th percentile. We used a multivariable log-binomial model to estimate relative risk of obesity adjusting for gender, baseline age, race/ethnicity, duration of follow-up, and baseline weight-for-length percentile. RESULTS: The incidence of obesity was 11.0% after the follow-up period. The incidence was significantly higher among boys versus girls and higher among children aged 0 to 11 months at baseline versus those older. Compared with non-Hispanic whites, the risk of obesity was 35% higher among Hispanics and 49% higher among American Indians (AIs)/Alaska Natives (ANs), but 8% lower among non-Hispanic African Americans. Among children who were obese at baseline, 36.5% remained obese and 63.5% were nonobese at follow-up. The proportion of reversing of obesity was significantly lower among Hispanics and AIs/ANs than that among other racial/ethnic groups. CONCLUSIONS: The high incidence underscores the importance of early-life obesity prevention in multiple settings for low-income children and their families. The variations within population subgroups suggest that culturally appropriate intervention efforts should be focused on Hispanics and AIs/ANs. C1 [Pan, Liping; May, Ashleigh L.; Wethington, Holly; Dalenius, Karen; Grummer-Strawn, Laurence M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. RP Pan, LP (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Highway,Mail Stop F-77, Atlanta, GA 30341 USA. EM Lpan@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 23 Z9 23 U1 3 U2 19 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD DEC PY 2013 VL 132 IS 6 BP 1006 EP 1013 DI 10.1542/peds.2013-2145 PG 8 WC Pediatrics SC Pediatrics GA 282IG UT WOS:000329163900040 PM 24276843 ER PT J AU Hampton, LM Nguyen, DB Edwards, JR Budnitz, DS AF Hampton, Lee M. Nguyen, Duc B. Edwards, Jonathan R. Budnitz, Daniel S. TI Cough and Cold Medication Adverse Events After Market Withdrawal and Labeling Revision SO PEDIATRICS LA English DT Article DE adverse events; drug safety; poisoning; medication errors; drug packaging; nasal decongestants; expectorants; antitussive agents; product withdrawals; nonprescription drugs ID EMERGENCY-DEPARTMENT VISITS; OVER-THE-COUNTER; YOUNG-CHILDREN; POISON CENTERS; SURVEILLANCE; INGESTIONS AB BACKGROUND: In October 2007, manufacturers voluntarily withdrew over-the-counter (OTC) infant cough and cold medications (CCMs) from the US market. A year later, manufacturers announced OTC CCM labeling would be revised to warn against OTC CCM use by children aged <4 years. We determined whether emergency department (ED) visits for CCM adverse drug events (ADEs) declined after these interventions. METHODS: We used National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance data from 2004 to 2011 to estimate the number of ED visits for CCM ADEs before and after each intervention. RESULTS: Among children aged <2 years, ED visits for CCM ADEs decreased from 4.1% of all ADE ED visits before the market withdrawal to 2.4% of all ADE visits afterward (difference in proportion: -1.7%, 95% confidence interval [CI]: -2.7% to -0.6%). Among children aged 2 to 3 years, ED visits for CCM ADEs decreased from 9.5% of all ADE ED visits before the labeling revision announcement to 6.5% of all ADE visits afterward (difference in proportion: -3.0%, 95% CI: -5.4% to -0.6%). Unsupervised ingestions accounted for 64.3% (95% CI: 51.1% to 77.5%) of CCM ADE ED visits involving children aged <2 years after the withdrawal and 88.8% (95% CI: 83.8% to 93.8%) of visits involving children aged 2 to 3 years after the labeling revision announcement. CONCLUSIONS: After a voluntary market withdrawal and labeling revision, ED visits for CCM ADEs declined among children aged,2 years and 2 to 3 years relative to ADE ED visits for all drugs. Interventions addressing unsupervised ingestions are needed to reduce CCM ADEs. C1 [Hampton, Lee M.; Nguyen, Duc B.; Edwards, Jonathan R.; Budnitz, Daniel S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30329 USA. [Nguyen, Duc B.] Ctr Dis Control & Prevent, Sci Educ & Profess Dev Program Off, Epidem Intelligence Serv, Atlanta, GA 30329 USA. RP Hampton, LM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-24, Atlanta, GA 30329 USA. EM lhampton@cdc.gov FU Emory AIDS International Training and Research Program [NIH/FIC D43 TW01042] FX We thank Joel Friedman, Thomas Schroeder, Herman Burney, and the USConsumer Products Safety Commission analysts along with Ray Colucci and the National Electronic Injury Surveillance System coders for diligent data collection, Kelly Weidenbach and Katie Rose for data review and Maribeth Lovegrove for analytic assistance and insightful comments on the manuscript. Dr Nguyen would like to acknowledge previous training support from the Emory AIDS International Training and Research Program (grant NIH/FIC D43 TW01042). NR 32 TC 12 Z9 12 U1 0 U2 3 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD DEC PY 2013 VL 132 IS 6 BP 1047 EP 1054 DI 10.1542/peds.2013-2236 PG 8 WC Pediatrics SC Pediatrics GA 282IG UT WOS:000329163900045 PM 24218462 ER PT J AU Holt, MK Matjasko, JL Espelage, D Reid, G Koenig, B AF Holt, Melissa K. Matjasko, Jennifer L. Espelage, Dorothy Reid, Gerald Koenig, Brian TI Sexual Risk Taking and Bullying Among Adolescents SO PEDIATRICS LA English DT Article DE bullying; sexual behavior; sexual orientation ID HIGH-SCHOOL-STUDENTS; SUBSTANCE USE; BEHAVIOR; HEALTH; VICTIMIZATION; AGGRESSION; CHILDHOOD; ASSOCIATIONS; MALTREATMENT; ORIENTATION AB BACKGROUND: Psychological and educational correlates of bullying have been explored extensively. However, little information is available about the link between bullying and sexual risk-taking behaviors among adolescents, though for some youth it may be that sexual risk taking emerges in response to bullying involvement. Associations for both heterosexual youth and those who identify as gay, lesbian, bisexual, transgender, or questioning (GLBTQ) should be considered, as should the influence of victimization exposures in other domains. Accordingly, associations among bullying, other victimization forms, and sexual risk-taking behaviors were examined among adolescents with particular consideration to sexual orientation. METHODS: A sample of 8687 high school students completed the Dane County Youth Survey, a countywide survey administered high school students from 24 schools. Participants were asked questions about their bullying involvement and sexual risk-taking behaviors (ie, engaging in casual sex and having sex while under the influence of alcohol or drugs). RESULTS: Results indicated that bullies and bully-victims were more likely to engage in casual sex and sex under the influence. In multivariate analyses, these findings held even after controlling for demographic characteristics and victimization exposures in other domains, but primarily for heterosexual youth. CONCLUSIONS: Bullies and bully-victims engaged in more sexual risk-taking behaviors, although patterns of association varied by sexual orientation. Bullying prevention programs and programs aimed at reducing unhealthy sexual practices should consider a broader stress and coping perspective and address the possible link between the stress of bullying involvement and maladaptive coping responses. C1 [Holt, Melissa K.; Reid, Gerald] Boston Univ, Sch Educ, Boston, MA 02215 USA. [Matjasko, Jennifer L.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA. [Espelage, Dorothy] Univ Illinois, Coll Educ, Champaign, IL USA. [Koenig, Brian] K 12 Associates, Madison, WI USA. RP Holt, MK (reprint author), Boston Univ, Sch Educ, 2 Silber Way, Boston, MA 02215 USA. EM holtm@bu.edu FU Dane County Youth Commission; Dane County Department of Human Services; United Way of Dane County; Public Health Department of Madison and Dane County; Dane County School Districts; American Educational Research Association Meeting FX Funding for this project was supported by Dane County Youth Commission, the Dane County Department of Human Services, the United Way of Dane County, the Public Health Department of Madison and Dane County, and the participating Dane County School Districts. Dr Holt and Mr Reid received travel funding through the School of Education at Boston University to present findings from this study at the 2012 American Educational Research Association Meeting. NR 31 TC 3 Z9 4 U1 1 U2 12 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD DEC PY 2013 VL 132 IS 6 BP E1481 EP E1487 DI 10.1542/peds.2013-0401 PG 7 WC Pediatrics SC Pediatrics GA 282IG UT WOS:000329163900003 PM 24218467 ER PT J AU Johnson, MG Bradley, KK Mendus, S Burnsed, L Clinton, R Tiwari, T AF Johnson, Matthew G. Bradley, Kristy K. Mendus, Susan Burnsed, Laurence Clinton, Rachel Tiwari, Tejpratap TI Vaccine-Preventable Disease Among Homeschooled Children: Two Cases of Tetanus in Oklahoma SO PEDIATRICS LA English DT Article DE Oklahoma; prevention and control; schools; tetanus; vaccines ID UNITED-STATES AB Homeschooled children represent an increasing proportion of school-aged children in the United States. Immunization rates among homeschooled children are largely unknown because they are usually not subject to state-based school-entry vaccination requirements. Geographic foci of underimmunized children can increase the risk for outbreaks of vaccine-preventable diseases. In 2012, 2 cases of tetanus were reported in Oklahoma; both cases involved homeschooled children without documentation of diphtheria-tetanus-acellular pertussis vaccination. We describe the characteristics of both patients and outline innovative outreach measures with the potential to increase vaccination access and coverage among homeschooled children. C1 [Johnson, Matthew G.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Tiwari, Tejpratap] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bradley, Kristy K.] Oklahoma Dept Hlth, Off State Epidemiologist, Oklahoma City, OK 73117 USA. [Mendus, Susan] Oklahoma Dept Hlth, Immunizat Serv, Oklahoma City, OK 73117 USA. [Burnsed, Laurence; Clinton, Rachel] Oklahoma Dept Hlth, Acute Dis Serv, Oklahoma City, OK 73117 USA. RP Johnson, MG (reprint author), Oklahoma Dept Hlth, Acute Dis Serv, 1000 NE 10th St, Oklahoma City, OK 73117 USA. EM vil0@cdc.gov NR 10 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD DEC PY 2013 VL 132 IS 6 BP E1686 EP E1689 DI 10.1542/peds.2013-1636 PG 4 WC Pediatrics SC Pediatrics GA 282IG UT WOS:000329163900030 PM 24218463 ER PT J AU Louie, JK Yang, S Samuel, MC Uyeki, TM Schechter, R AF Louie, Janice K. Yang, Samuel Samuel, Michael C. Uyeki, Timothy M. Schechter, Robert TI Neuraminidase Inhibitors for Critically Ill Children With Influenza SO PEDIATRICS LA English DT Article DE influenza; neuraminidase inhibitor; antiviral; critically ill; mortality; children; pediatric; pediatric ICU ID OSELTAMIVIR TREATMENT; ANTIVIRAL TREATMENT; HOSPITALIZED-PATIENTS; SEASONAL INFLUENZA; RISK-FACTORS; INFECTION; OUTCOMES; A(H1N1); CALIFORNIA; IMPACT AB OBJECTIVE: Timely treatment with neuraminidase inhibitor (NAI) drugs appears to improve survival in adults hospitalized with influenza. We analyzed California surveillance data to determine whether NAI treatment improves survival in critically ill children with influenza. METHODS: We analyzed data abstracted from medical records to characterize the outcomes of patients aged 0 to 17 years hospitalized in ICUs with laboratory-confirmed influenza from April 3, 2009, through September 30, 2012. RESULTS: Seven hundred eighty-four influenza cases aged <18 years hospitalized in ICUs had information on treatment. Ninety percent (532 of 591) of cases during the 2009 H1N1 pandemic (April 3, 2009-August 31, 2010) received NAI treatment compared with 63% (121 of 193) of cases in the postpandemic period (September 1, 2010-September 30, 2012; P < .0001). Of 653 cases NAI-treated, 38 (6%) died compared with 11 (8%) of 131 untreated cases (odds ratio = 0.67, 95% confidence interval: 0.34-1.36). In a multivariate model that included receipt of mechanical ventilation and other factors associated with disease severity, the estimated risk of death was reduced in NAI-treated cases (odds ratio 0.36, 95% confidence interval: 0.16-0.83). Treatment within 48 hours of illness onset was significantly associated with survival (P = .04). Cases with NAI treatment initiated earlier in illness were less likely to die. CONCLUSIONS: Prompt treatment with NAIs may improve survival of children critically ill with influenza. Recent decreased frequency of NAI treatment of influenza may be placing untreated critically ill children at an increased risk of death. C1 [Louie, Janice K.; Yang, Samuel; Samuel, Michael C.; Schechter, Robert] Calif Dept Publ Hlth, Richmond, CA 94804 USA. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Louie, JK (reprint author), Calif Dept Publ Hlth, 850 Marina Bay Pkwy, Richmond, CA 94804 USA. EM Janice.louie@cdph.ca.gov FU California Department of Public Health FX All phases of this study were supported by the California Department of Public Health. No external funding was secured for this study. NR 30 TC 19 Z9 20 U1 0 U2 6 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD DEC PY 2013 VL 132 IS 6 BP E1539 EP E1545 DI 10.1542/peds.2013-2149 PG 7 WC Pediatrics SC Pediatrics GA 282IG UT WOS:000329163900010 PM 24276847 ER PT J AU Biggs, HM Hertz, JT Munishi, OM Galloway, RL Marks, F Saganda, W Maro, VP Crump, JA AF Biggs, Holly M. Hertz, Julian T. Munishi, O. Michael Galloway, Renee L. Marks, Florian Saganda, Wilbrod Maro, Venance P. Crump, John A. TI Estimating Leptospirosis Incidence Using Hospital-Based Surveillance and a Population-Based Health Care Utilization Survey in Tanzania SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID NORTHERN TANZANIA; INVASIVE BACTERIAL; FUNGAL-INFECTIONS; TYPHOID-FEVER; SALMONELLA; SEYCHELLES; CHILDREN; ILLNESS; BURDEN AB Background The incidence of leptospirosis, a neglected zoonotic disease, is uncertain in Tanzania and much of sub-Saharan Africa, resulting in scarce data on which to prioritize resources for public health interventions and disease control. In this study, we estimate the incidence of leptospirosis in two districts in the Kilimanjaro Region of Tanzania. Methodology/Principal Findings We conducted a population-based household health care utilization survey in two districts in the Kilimanjaro Region of Tanzania and identified leptospirosis cases at two hospital-based fever sentinel surveillance sites in the Kilimanjaro Region. We used multipliers derived from the health care utilization survey and case numbers from hospital-based surveillance to calculate the incidence of leptospirosis. A total of 810 households were enrolled in the health care utilization survey and multipliers were derived based on responses to questions about health care seeking in the event of febrile illness. Of patients enrolled in fever surveillance over a 1 year period and residing in the 2 districts, 42 (7.14%) of 588 met the case definition for confirmed or probable leptospirosis. After applying multipliers to account for hospital selection, test sensitivity, and study enrollment, we estimated the overall incidence of leptospirosis ranges from 75-102 cases per 100,000 persons annually. Conclusions/Significance We calculated a high incidence of leptospirosis in two districts in the Kilimanjaro Region of Tanzania, where leptospirosis incidence was previously unknown. Multiplier methods, such as used in this study, may be a feasible method of improving availability of incidence estimates for neglected diseases, such as leptospirosis, in resource constrained settings. Author Summary Leptospirosis is a zoonotic infection that occurs worldwide and is caused by a spirochete, Leptospira spp. The incidence of leptospirosis is unknown in most of sub-Saharan Africa, including Tanzania. Incidence estimates are important in prioritizing resources for disease prevention and control. In this study, we calculated leptospirosis incidence in 2 districts in the Kilimanjaro Region of Tanzania using a multiplier method. We used responses from a population-based survey that asked where participants and their household members would seek health care in the event of fever along with the number of leptospirosis cases found at 2 hospitals under surveillance to calculate estimated incidence. We calculated a high incidence of leptospirosis in the study area that was previously unrecognized. This has important implications for prioritizing further research and consideration of public health control measures for leptospirosis in Tanzania. C1 [Biggs, Holly M.; Hertz, Julian T.; Crump, John A.] Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA. [Munishi, O. Michael; Maro, Venance P.; Crump, John A.] Kilimanjaro Christian Med Ctr, Moshi, Tanzania. [Galloway, Renee L.] Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Atlanta, GA USA. [Marks, Florian] Int Vaccine Inst, Seoul, South Korea. [Saganda, Wilbrod] Mawenzi Reg Hosp, Moshi, Tanzania. [Maro, Venance P.; Crump, John A.] Kilimanjaro Christian Med Univ Coll, Moshi, Tanzania. [Crump, John A.] Duke Univ, Duke Global Hlth Inst, Durham, NC USA. RP Biggs, HM (reprint author), Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA. EM john.crump@duke.edu FU International Studies on AIDS Associated Co-infections (ISAAC) award, a United States National Institutes of Health (NIH) [U01 AI062563]; Typhoid Fever Surveillance in sub-Saharan Africa Program (TSAP) grant [OPPGH5231]; US National Institutes of Health grant as part of the joint NIH-NSF Ecology of Infectious Disease program [R01TW009237]; UK Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; NIH [2P30 AI064518]; NIH Fogarty International Center AIDS International Training and Research Program [D43 PA-03-018]; Duke Clinical Trials Unit and Clinical Research Sites [U01 AI069484]; [NIAID-AI007392] FX This research was supported by an International Studies on AIDS Associated Co-infections (ISAAC) award, a United States National Institutes of Health (NIH) funded program (U01 AI062563). This work was funded in part by the Typhoid Fever Surveillance in sub-Saharan Africa Program (TSAP) grant OPPGH5231 and US National Institutes of Health grant R01TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program and the UK Economic and Social Research Council and Biotechnology and Biological Sciences Research Council. This publication was made possible with help from the Duke University Center for AIDS Research (CFAR), an NIH funded program (2P30 AI064518). Authors received support from the NIH Fogarty International Center AIDS International Training and Research Program D43 PA-03-018 (VPM, JAC), NIAID-AI007392 (HMB), and the Duke Clinical Trials Unit and Clinical Research Sites U01 AI069484 (JAC, VPM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 8 Z9 8 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2013 VL 7 IS 12 AR e2589 DI 10.1371/journal.pntd.0002589 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 282JU UT WOS:000329168100006 PM 24340122 ER PT J AU Chu, BK Deming, M Biritwum, NK Bougma, WR Dorkenoo, AM El-Setouhy, M Fischer, PU Gass, K de Pena, M Mercado-Hernandez, L Kyelem, D Lammie, PJ Flueckiger, RM Mwingira, UJ Noordin, R Owusu, IO Ottesen, EA Pavluck, A Pilotte, N Rao, RU Samarasekera, D Schmaedick, MA Settinayake, S Simonsen, PE Supali, T Taleo, F Torres, M Weil, GJ Won, KY AF Chu, Brian K. Deming, Michael Biritwum, Nana-Kwadwo Bougma, Windtare R. Dorkenoo, Ameyo M. El-Setouhy, Maged Fischer, Peter U. Gass, Katherine de Pena, Manuel Gonzalez Mercado-Hernandez, Leda Kyelem, Dominique Lammie, Patrick J. Flueckiger, Rebecca M. Mwingira, Upendo J. Noordin, Rahmah Owusu, Irene Offei Ottesen, Eric A. Pavluck, Alexandre Pilotte, Nils Rao, Ramakrishna U. Samarasekera, Dilhani Schmaedick, Mark A. Settinayake, Sunil Simonsen, Paul E. Supali, Taniawati Taleo, Fasihah Torres, Melissa Weil, Gary J. Won, Kimberly Y. TI Transmission Assessment Surveys (TAS) to Define Endpoints for Lymphatic Filariasis Mass Drug Administration: A Multicenter Evaluation SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID WUCHERERIA-BANCROFTI; GLOBAL PROGRAM; ELIMINATION; SURVEILLANCE; VECTOR; TOOLS; HAITI AB Background Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention. Guidelines advanced by WHO call for a transmission assessment survey (TAS) to determine if MDA can be stopped within an LF evaluation unit (EU) after at least five effective rounds of annual treatment. To test the value and practicality of these guidelines, a multicenter operational research trial was undertaken in 11 countries covering various geographic and epidemiological settings. Methodology The TAS was conducted twice in each EU with TAS-1 and TAS-2 approximately 24 months apart. Lot quality assurance sampling (LQAS) formed the basis of the TAS survey design but specific EU characteristics defined the survey site (school or community), eligible population (6-7 year olds or 1(st)-2(nd) graders), survey type (systematic or cluster-sampling), target sample size, and critical cutoff (a statistically powered threshold below which transmission is expected to be no longer sustainable). The primary diagnostic tools were the immunochromatographic (ICT) test for W. bancrofti EUs and the BmR1 test (Brugia Rapid or PanLF) for Brugia spp. EUs. Principal Findings/Conclusions In 10 of 11 EUs, the number of TAS-1 positive cases was below the critical cutoff, indicating that MDA could be stopped. The same results were found in the follow-up TAS-2, therefore, confirming the previous decision outcome. Sample sizes were highly sex and age-representative and closely matched the target value after factoring in estimates of non-participation. The TAS was determined to be a practical and effective evaluation tool for stopping MDA although its validity for longer-term post-MDA surveillance requires further investigation. Author Summary Lymphatic filariasis (LF) is targeted for global elimination through a strategy of repeated annual mass drug administration (MDA) to entire at-risk populations. A transmission assessment survey (TAS) is designed to evaluate whether transmission of LF is presumed to have reached a level low enough that it cannot be sustained in the absence of drug intervention and, therefore, MDA can be stopped. This multicenter operational research trial examines the value and practicality of the TAS guidelines through its implementation in 11 countries of diverse geographical and epidemiologic profiles. The field experiences support the TAS survey design methodology with particular respect to school and cluster-based sampling strategies. We found that sample sizes were age and sex representative and met the target values after factoring in estimates of non-participation rates. In 10 of 11 countries, the TAS found the number of positive cases in the evaluation unit to be no more than the statistically powered critical threshold. These results were corroborated in a follow-up TAS approximately 24 months later. We conclude the TAS is a valuable and effective tool for stopping MDA but its utility for longer-term post-MDA surveillance needs further empirical evidence and may be best supported with complementary tools and methods. C1 [Chu, Brian K.; Gass, Katherine; Kyelem, Dominique; Flueckiger, Rebecca M.; Ottesen, Eric A.; Pavluck, Alexandre] Neglected Trop Dis Support Ctr, Task Force Global Hlth, Decatur, GA USA. [Deming, Michael; Lammie, Patrick J.; Won, Kimberly Y.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Biritwum, Nana-Kwadwo] Ghana Hlth Serv, Dept Publ Hlth, Accra, Ghana. [Bougma, Windtare R.] Minist Sante, Programme Natl Eliminat Filariose Lymphat, Ouagadougou, Burkina Faso. [Dorkenoo, Ameyo M.] Minist Sante, Programme Natl Eliminat Filariose Lymphat, Lome, Togo. [El-Setouhy, Maged] Ain Shams Univ, Dept Community Environm & Occupat Med, Cairo, Egypt. [Fischer, Peter U.; Weil, Gary J.] Washington Univ Sch Med, Div Infect Dis, St Louis, MO USA. [de Pena, Manuel Gonzalez] Ctr Natl Control Enfermedades Trop, Santo Domingo, Dominican Rep. [Mercado-Hernandez, Leda] Natl Ctr Dis Prevent & Control, Infect Dis Off, Manila, Philippines. [Mwingira, Upendo J.] Natl Inst Med Res, Neglected Trop Dis Control Programme, Dar Es Salaam, Tanzania. [Noordin, Rahmah] Univ Sains Malaysia, Inst Res Mol Med, George Town, Malaysia. [Owusu, Irene Offei] Noguchi Mem Inst Med Res, Dept Epidemiol, Legon, Ghana. [Pilotte, Nils; Torres, Melissa] Smith Coll, Dept Biol Sci, Northampton, MA 01063 USA. [Rao, Ramakrishna U.] Washington Univ Sch Med, Dept Internal Med, St Louis, MO USA. [Samarasekera, Dilhani; Settinayake, Sunil] Minist Hlth, Colombo, Sri Lanka. [Schmaedick, Mark A.] Amer Samoa Community Coll, Div Community & Nat Resources, Pago Pago, AS USA. [Simonsen, Paul E.] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. [Supali, Taniawati] Univ Indonesia, Dept Parasitol, Jakarta, Indonesia. [Taleo, Fasihah] Publ Hlth Directorate, Neglected Trop Dis Unit, Port Vila, Vanuatu. RP Chu, BK (reprint author), Task Force Global Hlth, Neglected Trop Dis Support Ctr, Decatur, GA USA. EM bchu@taskforce.org RI Noordin, Rahmah/A-8277-2011 OI Noordin, Rahmah/0000-0001-7583-0752 FU Bill and Melinda Gates Foundation [OPP43922] FX Funding for this study was provided by the Bill and Melinda Gates Foundation, Grant #OPP43922. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 26 TC 21 Z9 22 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2013 VL 7 IS 12 AR e2584 DI 10.1371/journal.pntd.0002584 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 282JU UT WOS:000329168100010 PM 24340120 ER PT J AU Hester, J Chan, ER Menard, D Mercereau-Puijalon, O Barnwell, J Zimmerman, PA Serre, D AF Hester, James Chan, Ernest R. Menard, Didier Mercereau-Puijalon, Odile Barnwell, John Zimmerman, Peter A. Serre, David TI De Novo Assembly of a Field Isolate Genome Reveals Novel Plasmodium vivax Erythrocyte Invasion Genes SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HUMAN MALARIA PARASITE; DUFFY ANTIGEN; PROTEIN; FALCIPARUM; RECEPTOR; REGION; SUPERFAMILY; POPULATION; DOMAIN; POLYMORPHISMS AB Recent sequencing of Plasmodium vivax field isolates and monkey-adapted strains enabled characterization of SNPs throughout the genome. These analyses relied on mapping short reads onto the P. vivax reference genome that was generated using DNA from the monkey-adapted strain Salvador I. Any genomic locus deleted in this strain would be lacking in the reference genome sequence and missed in previous analyses. Here, we report de novo assembly of a P. vivax field isolate genome. Out of 2,857 assembled contigs, we identify 362 contigs, each containing more than 5 kb of contiguous DNA sequences absent from the reference genome sequence. These novel P. vivax DNA sequences account for 3.8 million nucleotides and contain 792 predicted genes. Most of these contigs contain members of multigene families and likely originate from telomeric regions. Interestingly, we identify two contigs containing predicted protein coding genes similar to known Plasmodium red blood cell invasion proteins. One gene encodes the reticulocyte-binding protein gene orthologous to P. cynomolgi RBP2e and P. knowlesi NBPXb. The second gene harbors all the hallmarks of a Plasmodium erythrocyte-binding protein, including conserved Duffy-binding like and C-terminus cysteine-rich domains. Phylogenetic analysis shows that this novel gene clusters separately from all known Plasmodium Duffy-binding protein genes. Additional analyses showing that this gene is present in most P. vivax genomes and transcribed in blood-stage parasites suggest that P. vivax red blood cell invasion mechanisms may be more complex than currently understood. The strategy employed here complements previous genomic analyses and takes full advantage of next-generation sequencing data to provide a comprehensive characterization of genetic variations in this important malaria parasite. Further analyses of the novel protein coding genes discovered through de novo assembly have the potential to identify genes that influence key aspects of P. vivax biology, including alternative mechanisms of human erythrocyte invasion. Author SummaryPlasmodium vivax is responsible for most malaria cases outside Africa, but is poorly understood, as the parasite is difficult to study in vitro. Genome sequencing studies offer a novel and exciting opportunity to better understand this parasite but, so far, have directly mapped reads onto the reference genome sequence generated from a single P. vivax strain. Here, we use sequence data generated from a field isolate to reconstruct long DNA sequences without relying on the reference genome. Our analyses reveal many P. vivax DNA sequences that are absent from the reference genome and contain 792 predicted genes. One of these novel genes encodes a predicted protein similar to known Plasmodium proteins involved in red blood cell invasion. This new gene is present in all P. vivax strains sequenced so far, except for the strain used to generate the reference genome, and is transcribed in blood-stage parasites. Overall, our analyses show that the catalogue of P. vivax genes was incomplete and that potentially important genes have been missed. We notably identified one putative invasion gene that seems functional and could dramatically change our understanding of the mechanisms determining red blood cell invasion by this important malaria parasite. C1 [Hester, James; Chan, Ernest R.; Serre, David] Cleveland Clin, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44106 USA. [Menard, Didier] Inst Pasteur Cambodge, Unite Epidemiol Mol, Phnom Penh, Cambodia. [Mercereau-Puijalon, Odile] Inst Pasteur, Unite Immunol Mol Parasites, Paris, France. [Barnwell, John] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Zimmerman, Peter A.] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. RP Hester, J (reprint author), Cleveland Clin, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44106 USA. EM paz@case.edu; serred@ccf.org OI Hester, James/0000-0002-2739-7082; Zimmerman, Peter/0000-0002-5349-4513 FU Cleveland CTSC Pilot award; NIAID award [R01 AI103228, R21 AI093922]; French Ministry of Foreign Affairs FX This work was funded by a Cleveland CTSC Pilot award and a NIAID award (R01 AI103228) to DS and a NIAID award (R21 AI093922) to PAZ. DM was supported by the French Ministry of Foreign Affairs during this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 25 Z9 25 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2013 VL 7 IS 12 AR e2569 DI 10.1371/journal.pntd.0002569 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 282JU UT WOS:000329168100036 PM 24340114 ER PT J AU Ford, ES AF Ford, Earl S. TI Food Security and Cardiovascular Disease Risk Among Adults in the United States: Findings From the National Health and Nutrition Examination Survey, 2003-2008 SO PREVENTING CHRONIC DISEASE LA English DT Article ID INSECURITY; OBESITY; ADOLESCENTS; STRATEGIES; SMOKING; HUNGER AB Introduction Little is known about the relationship between food security status and predicted 10-year cardiovascular disease risk. The objective of this study was to examine the associations between food security status and cardiovascular disease risk factors and predicted 10-year risk in a national sample of US adults. Methods A cross-sectional analysis using data from 10,455 adults aged 20 years or older from the National Health and Nutrition Examination Survey 2003-2008 was conducted. Four levels of food security status were defined by using 10 questions. Results Among all participants, 83.9% had full food security, 6.7% had marginal food security, 5.8% had low food security, and 3.6% had very low food security. After adjustment, mean hemoglobin A1c was 0.15% greater and mean concentration of C-reactive protein was 0.8 mg/L greater among participants with very low food security than among those with full food security. The adjusted mean concentration of cotinine among participants with very low food security was almost double that of participants with full food security (112.8 vs 62.0 ng/mL, P < .001). No significant associations between food security status and systolic blood pressure or concentrations of total cholesterol, high-density lipoprotein cholesterol, or non-high-density lipoprotein cholesterol were observed. Participants aged 30 to 59 years with very low food security were more likely to have a predicted 10-year cardiovascular disease risk greater than 20% than fully food secure participants (adjusted prevalence ratio, 2.38; 95% CI, 1.31-4.31). Conclusion Adults aged 30 to 59 years with very low food security showed evidence of increased predicted 10-year cardiovascular disease risk. C1 Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, 4770 Buford Hwy,MS F78, Atlanta, GA 30341 USA. EM cford@cdc.gov NR 30 TC 6 Z9 6 U1 2 U2 20 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD DEC PY 2013 VL 10 AR UNSP 130244 DI 10.5888/pcd10.130244 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 285ME UT WOS:000329397300001 ER PT J AU Richter, PA Bishop, EE Wang, JT Kaufmann, R AF Richter, Patricia A. Bishop, Ellen E. Wang, Jiantong Kaufmann, Rachel TI Trends in Tobacco Smoke Exposure and Blood Lead Levels Among Youths and Adults in the United States: The National Health and Nutrition Examination Survey, 1999-2008 SO PREVENTING CHRONIC DISEASE LA English DT Article ID US CHILDREN; POPULATION AB Introduction Tobacco smoke is a source of exposure to thousands of toxic chemicals including lead, a chemical of longstanding public health concern. We assessed trends in blood lead levels in youths and adults with cotinine-verified tobacco smoke exposure by using 10 years of data from the National Health and Nutrition Examination Survey. Methods Geometric mean levels of blood lead are presented for increasing levels of tobacco smoke exposure. Regression models for lead included age, race/ethnicity, poverty, survey year, sex, age of home, birth country, and, for adults, alcohol consumption. Lead levels were evaluated for smokers and nonsmokers on the basis of age of residence and occupation. Results Positive trend tests indicate that a linear relationship exists between smoke exposure and blood lead levels in youths and adults and that secondhand smoke exposure contributes to blood lead levels above the level caused by smoking. Conclusion Youths with secondhand smoke exposure had blood lead levels suggestive of the potential for adverse cognitive outcomes. Despite remediation efforts in housing and the environment and declining smoking rates and secondhand smoke exposure in the United States, tobacco smoke continues to be a substantial source of exposure to lead in vulnerable populations and the population in general. C1 [Richter, Patricia A.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Bishop, Ellen E.; Wang, Jiantong] RTI Int, Atlanta, GA USA. [Kaufmann, Rachel] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Richter, PA (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. EM patricia.richter@fda.hhs.gov FU Centers for Disease Control and Prevention (CDC) FX All research was supported by internal funds of the Centers for Disease Control and Prevention (CDC). The information and views expressed are those of the authors and do not necessarily represent the views of the US Food and Drug Administration (FDA) or of the US government. Dr Richter was employed by CDC when this study was designed and conducted. She is now employed by the FDA. NR 27 TC 8 Z9 8 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD DEC PY 2013 VL 10 AR UNSP 130056 DI 10.5888/pcd10.130056 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 285ME UT WOS:000329397300012 ER PT J AU Spencer, LM Schooley, MW Anderson, LA Kochtitzky, CS DeGroff, AS Devlin, HM Mercer, SL AF Spencer, Lorine M. Schooley, Michael W. Anderson, Lynda A. Kochtitzky, Chris S. DeGroff, Amy S. Devlin, Heather M. Mercer, Shawna L. TI Seeking Best Practices: A Conceptual Framework for Planning and Improving Evidence-Based Practices SO PREVENTING CHRONIC DISEASE LA English DT Article ID PUBLIC-HEALTH; PREVENTION; STRATEGIES; OBESITY AB How can we encourage ongoing development, refinement, and evaluation of practices to identify and build an evidence base for best practices? On the basis of a review of the literature and expert input, we worked iteratively to create a framework with 2 interrelated components. The first public health impact consists of 5 elements: effectiveness, reach, feasibility, sustainability, and transferability. The second quality of evidence consists of 4 levels, ranging from weak to rigorous. At the intersection of public health impact and quality of evidence, a continuum of evidence-based practice emerges, representing the ongoing development of knowledge across 4 stages: emerging, promising, leading, and best. This conceptual framework brings together important aspects of impact and quality to provide a common lexicon and criteria for assessing and strengthening public health practice. We hope this work will invite and advance dialogue among public health practitioners and decision makers to build and strengthen a diverse evidence base for public health programs and strategies. C1 [Spencer, Lorine M.] Ctr Dis Control & Prevent, Appl Syst Res & Evaluat Branch, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA 30341 USA. [Schooley, Michael W.; Kochtitzky, Chris S.; DeGroff, Amy S.; Devlin, Heather M.; Mercer, Shawna L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Anderson, Lynda A.] Emory Univ, Atlanta, GA 30322 USA. RP Spencer, LM (reprint author), Ctr Dis Control & Prevent, Appl Syst Res & Evaluat Branch, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, 4770 Buford Hwy NE,Mailstop E70, Atlanta, GA 30341 USA. EM akx4@cdc.gov NR 24 TC 8 Z9 8 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD DEC PY 2013 VL 10 AR UNSP 130186 DI 10.5888/pcd10.130186 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 285ME UT WOS:000329397300006 ER PT J AU Lessa, FC AF Lessa, Fernanda C. TI Community-associated Clostridium difficile infection: How real is it? SO ANAEROBE LA English DT Article; Proceedings Paper CT 11th Biennial Congress of the Anaerobe-Society-of-the-Americas CY JUN 27-JUL 01, 2012 CL San Francisco, CA SP Anaerobe Soc Amer DE Community-associated; Clostridium difficile infection; Surveillance ID RISK; METAANALYSIS; HOSPITALS; OUTBREAK; DISEASE; COUNTY; MEAT AB Community-associated Clostridium difficile infection (CA-CDI) represents 32% of all CDI cases based on U.S. population-based data. The current epidemic strain, NAP1, is the most prevalent strain causing these infections. Although complications, recurrence and death are uncommon, one-fourth of the CA-CDI patients are hospitalized within 7 days after the diagnosis. Published by Elsevier Ltd. C1 Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Lessa, FC (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,MS A-24, Atlanta, GA 30333 USA. EM flessa@cdc.gov NR 23 TC 19 Z9 19 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1075-9964 EI 1095-8274 J9 ANAEROBE JI Anaerobe PD DEC PY 2013 VL 24 BP 121 EP 123 DI 10.1016/j.anaerobe.2013.01.006 PG 3 WC Microbiology SC Microbiology GA 278TJ UT WOS:000328912400025 PM 23403280 ER PT J AU Schier, JG Hunt, DR Perala, A McMartin, KE Bartels, MJ Lewis, LS McGeehin, MA Flanders, WD AF Schier, J. G. Hunt, D. R. Perala, A. McMartin, K. E. Bartels, M. J. Lewis, L. S. McGeehin, M. A. Flanders, W. D. TI Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning SO CLINICAL TOXICOLOGY LA English DT Article DE Kidney; CNS/psychological; Metabolic; diethylene glycol; diglycolic acid; hydroxyethoxyacetic acid ID NEPHROTOXIC METABOLITE; DIGLYCOLIC ACID; IDENTIFICATION; TOXICITY; RATS; 1,4-DIOXANE; ETHYLENE AB Context. Diethylene glycol (DEG) mass poisoning is a persistent public health problem. Unfortunately, there are no human biological data on DEG and its suspected metabolites in poisoning. If present and associated with poisoning, the evidence for use of traditional therapies such as fomepizole and/or hemodialysis would be much stronger. Objective. To characterize DEG and its metabolites in stored serum, urine, and cerebrospinal fluid (CSF) specimens obtained from human DEG poisoning victims enrolled in a 2006 case-control study. Methods. In the 2006 study, biological samples from persons enrolled in a case-control study (42 cases with new-onset, unexplained AKI and 140 age-, sex-, and admission date-matched controls without AKI) were collected and shipped to the Centers for Disease Control and Prevention (CDC) in Atlanta for various analyses and were then frozen in storage. For this study, when sufficient volume of the original specimen remained, the following analytes were quantitatively measured in serum, urine, and CSF: DEG, 2-hydroxyethoxyacetic acid (HEAA), diglycolic acid, ethylene glycol, glycolic acid, and oxalic acid. Analytes were measured using low resolution GC/MS, descriptive statistics calculated and case results compared with controls when appropriate. Specimens were de-identified so previously collected demographic, exposure, and health data were not available. The Wilcoxon Rank Sum test (with exact p-values) and bivariable exact logistic regression were used in SAS v9.2 for data analysis. Results. The following samples were analyzed: serum, 20 case, and 20 controls; urine, 11 case and 22 controls; and CSF, 11 samples from 10 cases and no controls. Diglycolic acid was detected in all case serum samples (median, 40.7 mcg/mL; range, 22.6-75.2) and no controls, and in all case urine samples (median, 28.7 mcg/mL; range, 14-118.4) and only five (23%) controls (median, 999; exact p < 0.0001); and 3) urinary glycolic acid (OR = 0.057; 95% C I = 0.001-0.55). Two CSF sample results were excluded and two from the same case were averaged, yielding eight samples from eight cases. Diglycolic acid was detected in seven (88%) of case CSF samples (median, 2.03 mcg/mL; range, < LLQ, 7.47). Discussion. Significantly elevated HEAA (serum) and diglycolic acid (serum and urine) concentrations were identified among cases, which is consistent with animal data. Low urinary glycolic acid concentrations in cases may have been due to concurrent AKI. Although serum glycolic concentrations among cases may have initially increased, further metabolism to oxalic acid may have occurred thereby explaining the similar glycolic acid concentrations in cases and controls. The increased serum oxalic acid concentration results in cases versus controls are consistent with this hypothesis. Conclusion. Diglycolic acid is associated with human DEG poisoning and may be a biomarker for poisoning. These findings add to animal data suggesting a possible role for traditional antidotal therapies. The detection of HEAA and diglycolic acid in the CSF of cases suggests a possible association with signs and symptoms of DEG-associated neurotoxicity. Further work characterizing the pathophysiology of DEG-associated neurotoxicity and the role of traditional toxic alcohol therapies such as fomepizole and hemodialysis is needed. C1 [Schier, J. G.; Hunt, D. R.; Lewis, L. S.; McGeehin, M. A.; Flanders, W. D.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. [Schier, J. G.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA USA. [Perala, A.; Bartels, M. J.] Dow Chem Co USA, Atlanta, GA USA. [McMartin, K. E.] LSU Hlth Sci Ctr Shreveport, Shreveport, LA USA. RP Schier, JG (reprint author), CDC, NCEH, EHHE, HSB, MS F-60,4770 Buford Hwy, Chamblee, GA 30341 USA. EM jschier@cdc.gov FU Orphan Medical; Centers for Disease Control and Prevention FX Dr. McMartin has received royalty payments for Antizol (R) (original fomepizole brand) from Orphan Medical and its descendants because of a licensing agreement with Mericon Investment Group.; Support for the laboratory analysis portion done by Dow Chemical Company of this study came from the Centers for Disease Control and Prevention. NR 22 TC 11 Z9 11 U1 0 U2 19 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 EI 1556-9519 J9 CLIN TOXICOL JI Clin. Toxicol. PD DEC PY 2013 VL 51 IS 10 BP 923 EP 929 DI 10.3109/15563650.2013.850504 PG 7 WC Toxicology SC Toxicology GA 280TD UT WOS:000329052800003 PM 24266434 ER PT J AU Calfee, MW Rose, LJ Morse, S Mattorano, D Clayton, M Touati, A Griffin-Gatchalian, N Slone, C McSweeney, N AF Calfee, M. Worth Rose, Laura J. Morse, Stephen Mattorano, Dino Clayton, Matt Touati, Abderrahmane Griffin-Gatchalian, Nicole Slone, Christina McSweeney, Neal TI Comparative evaluation of vacuum-based surface sampling methods for collection of Bacillus spores SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Surface sampling; Anthrax; Bacillus anthracis; Bioterrorism agent; Vacuum sampling ID ANTHRACIS SPORES; NONPOROUS SURFACES; DECONTAMINATION; RECOVERY; STERNE; ISSUES; SCALE; GAPS AB In this study, four commonly-used sampling devices (vacuum socks, 37 mm 0.8 mu m mixed cellulose ester (MCE) filter cassettes, 37 mm 0.3 mu m polytetrafluoroethylene (PTFE) filter cassettes, and 3M (TM) forensic filters) were comparatively evaluated for their ability to recover surface-associated spores. Aerosolized spores (similar to 10(5) CPU cm(-2)) of a Bacillus anthracis surrogate were allowed to settle onto three material types (concrete, carpet, and upholstery). Ten replicate samples were collected using each vacuum method, from each material type. Stainless steel surfaces, inoculated simultaneously with test materials, were sampled with pre-moistened wipes. Wipe recoveries were utilized to normalize vacuum-based recoveries across trials. Recovery (CFU cm(-2)) and relative recovery (vacuum recovery/wipe recovery) were determined for each method and material type. Recoveries and relative recoveries ranged from 3.8 x 10(3) to 7.4 x 10(4) CFU cm(-2) and 0.035 to 1242, respectively. ANOVA results indicated that the 37 mm MCE method exhibited higher relative recoveries than the other methods when used for sampling concrete or upholstery. While the vacuum sock resulted in the highest relative recoveries on carpet, no statistically significant difference was detected. The results of this study may be used to guide selection of sampling approaches following biological contamination incidents. Published by Elsevier B.V. C1 [Calfee, M. Worth] US EPA, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Rose, Laura J.; Morse, Stephen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mattorano, Dino] US EPA, Off Emergency Management, Cincinnati, OH 45268 USA. [Clayton, Matt; Touati, Abderrahmane; Griffin-Gatchalian, Nicole; McSweeney, Neal] ARCADIS Geraghty & Miller Inc, Durham, NC USA. [Slone, Christina] Kultech Inc, Cary, NC USA. RP Calfee, MW (reprint author), US EPA, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM calfee.worth@epa.gov OI Calfee, Michael/0000-0001-6544-329X FU CDC [RW-75-92345701]; US EPA [RW-75-92345701] FX The U.S. Environmental Protection Agency through its Office of Research and Development directed the research described herein under EP-C-09-027 with ARCADIS, Inc. This study was funded through an interagency agreement between the CDC and the US EPA (RW-75-92345701). The authors gratefully acknowledge the critical reviews by Sanjiv Shah (EPA) and Matthew Arduino (CDC). This manuscript has been subject to an administrative review but the findings and conclusions in this article are of the authors, and do not necessarily reflect the views of the EPA or CDC. No official endorsement should be inferred. The US EPA and CDC do not endorse the purchase or sale of any commercial products or services. NR 31 TC 4 Z9 4 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD DEC PY 2013 VL 95 IS 3 SI SI BP 389 EP 396 DI 10.1016/j.mimet.2013.10.015 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 280BK UT WOS:000329003500016 PM 24184017 ER PT J AU Barrera, R Mackay, AJ Amador, M AF Barrera, Roberto Mackay, Andrew J. Amador, Manuel TI AN IMPROVED TRAP TO CAPTURE ADULT CONTAINER-INHABITING MOSQUITOES SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; Aedes mediovittatus; dengue; vector surveillance; BG-Sentinel traps ID AEDES-AEGYPTI DIPTERA; YELLOW-FEVER MOSQUITOS; BG-SENTINEL TRAP; FAY-PRINCE TRAPS; PUERTO-RICO; CARBON-DIOXIDE; MEDIOVITTATUS DIPTERA; FRENCH-POLYNESIA; DENGUE VIRUSES; AMERICAN-SAMOA AB Although dengue viruses are thought to be transmitted by Aedes aegypti in Puerto Rico, Aedes mediovittatus, the Caribbean tree hole mosquito, is also a potential vector. This species is native to the Greater Antilles and has been shown to be a competent vector of dengue viruses in the laboratory. Consequently, it has been suggested that Ae. mediovittatus could be acting as a secondary vector or virus reservoir. This study was part of an ongoing investigation into this, and it aimed to determine whether BG-Sentinel traps (BGS traps) could be used to collect adults of this mosquito and could be modified to increase the number of captures of this species in the field. We conducted experiments to test the relative attractiveness of BGS traps to Ae. mediovittatus and Ae. aegypti and explored the effects of chemical lures (BG-Lure, CO2, octenol) and optical properties (color, size) on the capture rates of BGS traps in a large, outdoor cage in San Juan city, Puerto Rico. We also conducted field tests to compare modified BGS traps with the original traps in a rural community in Patillas municipality, Puerto Rico. Results obtained from the large, outdoor cage experiments indicated that trap captures of both mosquito species could be significantly enhanced by using black instead of white BGS traps combined with BG-Lure. Field experiments revealed that the modified traps captured a significantly greater number of Ae. aegypti, Ae. mediovittatus, and Culex quinquefasciatus, with greater sensitivity for the latter 2 species, and also captured a larger number of mosquito species and a smaller ratio of Ae. aegypti to Ae. mediovittatus, with greater than expected species co-occurrences. C1 [Barrera, Roberto; Mackay, Andrew J.; Amador, Manuel] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. RP Barrera, R (reprint author), Ctr Dis Control & Prevent, Dengue Branch, Calle Canada, San Juan, PR 00920 USA. RI Mashamba-Thompson, Tivani /B-6087-2014 FU Intramural CDC HHS [CC999999] NR 47 TC 7 Z9 7 U1 2 U2 14 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2013 VL 29 IS 4 BP 358 EP 368 DI 10.2987/13-6343.1 PG 11 WC Entomology SC Entomology GA 278OK UT WOS:000328899400006 PM 24551969 ER PT J AU Kothera, L Nelms, BM Reisen, WK Savage, HM AF Kothera, Linda Nelms, Brittany M. Reisen, William K. Savage, Harry M. TI Population Genetic and Admixture Analyses of Culex pipiens Complex (Diptera: Culicidae) Populations in California, United States SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID WEST-NILE-VIRUS; NEW-YORK-CITY; BELOW-GROUND POPULATIONS; NORTH-AMERICA; MICROSATELLITE LOCI; VECTOR COMPETENCE; FEEDING PATTERNS; MOSQUITOS; PROGRAM; QUINQUEFASCIATUS AB Microsatellite markers were used to genetically characterize 19 Culex pipiens complex populations from California. Two populations showed characteristics of earlier genetic bottlenecks. The overall F-ST value and a neighbor-joining tree suggested moderate amounts of genetic differentiation. Analyses using Structure indicated K = 4 genetic clusters: Cx. pipiens form pipiens L., Cx. quinquefasciatus Say, Cx. pipiens form molestus Forskal, and a group of genetically similar individuals of hybrid origin. A Discriminant Analysis of Principal Components indicated that the latter group is a mixture of the other three taxa, with form pipiens and form molestus contributing somewhat more ancestry than Cx. quinquefasciatus. Characterization of 56 morphologically autogenous individuals classified most as Cx. pipiens form molestus, and none as Cx. pipiens form pipiens or Cx. quinquefasciatus. Comparison of California microsatellite data with those of Cx. pipiens pallens Coquillett from Japan indicated the latter does not contribute significantly to genotypes in California. C1 [Kothera, Linda; Savage, Harry M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Nelms, Brittany M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA. RP Kothera, L (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM lkothera@cdc.gov; bnelms@wesphotos.com; wkreisen@ucdavis.edu; hms1@cdc.gov FU Sacramento-Yolo MVCD; National Institutes of Allergy and Infectious Diseases, National Institutes of Health (NIH) [RO1 AI55607]; NIH fellowship from the Training Program in Biology of Disease Vectors [T32-AI074550]; Research and Policy for Infectious Disease Dynamics Program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, NIH; Centers for Disease Control and Prevention in Fort Collins, Colorado FX This study was supported in part by a research grant from the Sacramento-Yolo MVCD and grant RO1 AI55607 from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health (NIH). Brittany M. Nelms was supported in part by an NIH fellowship from the Training Program in Biology of Disease Vectors, grant number T32-AI074550. William K. Reisen was supported by the Research and Policy for Infectious Disease Dynamics Program of the Science and Technology Directorate, Department of Homeland Security and the Fogarty International Center, NIH. Linda Kothera and Harry M. Savage are supported by the Centers for Disease Control and Prevention in Fort Collins, Colorado. NR 56 TC 8 Z9 8 U1 0 U2 10 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1154 EP 1167 DI 10.4269/ajtmh.13-0040 PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100017 PM 23958909 ER PT J AU Nelms, BM Kothera, L Thiemann, T Macedo, PA Savage, HM Reisen, WK AF Nelms, Brittany M. Kothera, Linda Thiemann, Tara Macedo, Paula A. Savage, Harry M. Reisen, William K. TI Phenotypic Variation among Culex pipiens Complex (Diptera: Culicidae) Populations from the Sacramento Valley, California: Horizontal and Vertical Transmission of West Nile Virus, Diapause Potential, Autogeny, and Host Selection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NORTHEASTERN UNITED-STATES; MOLESTUS FORSKAL DIPTERA; NEW-YORK-CITY; VECTOR COMPETENCE; QUINQUEFASCIATUS DIPTERA; NATURAL-POPULATIONS; SOUTHERN CALIFORNIA; OVARIAN DEVELOPMENT; FEEDING PATTERNS; TARSALIS DIPTERA AB The vector competence and bionomics of Culex pipiens form pipiens L. and Cx. pipiens f. molestus Forskal were evaluated for populations from the Sacramento Valley. Both f. pipiens and f. molestus females became infected, produced disseminated infections, and were able to transmit West Nile virus. Form molestus females also transmitted West Nile virus vertically to egg rafts and F, progeny, whereas f. pipiens females only transmitted to egg rafts. Culex pipiens complex from urban Sacramento blood-fed on seven different avian species and two mammalian species. Structure analysis of blood-fed mosquitoes identified K = 4 genetic clusters: f. molestus, f. pipiens, a group of genetically similar hybrids (Cluster X), and admixed individuals. When females were exposed as larvae to midwinter conditions in bioenvironmental chambers, 85% (N = 79) of aboveground Cx. pipiens complex females and 100% (N = 34) of underground f. molestus females did not enter reproductive diapause. C1 [Nelms, Brittany M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA. [Kothera, Linda; Savage, Harry M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Thiemann, Tara] Univ Pacific, Dept Biol Sci, Stockton, CA 95211 USA. [Macedo, Paula A.] SacramentoYolo Mosquito & Vector Control Dist, Elk Grove, CA USA. RP Reisen, WK (reprint author), Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA. EM bmmills@ucdavis.edu; lkothera@cdc.gov; tthiemann@pacific.edu; pmacedo@sac-yolomvcd.com; hmsl@cdc.gov; wkreisen@ucdavis.edu FU NIH Research grant from the National Institute of Allergy and Infectious Diseases, NIH [RO1 AI 55607]; Sacramento-Yolo MVCD; NIH fellowship from the Training Program in Biology of Disease Vectors [T32AI074550]; Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health FX This research was supported by NIH Research grant RO1 AI 55607 from the National Institute of Allergy and Infectious Diseases, NIH, funds provided by the Sacramento-Yolo MVCD and an NIH fellowship from the Training Program in Biology of Disease Vectors, grant no. T32AI074550. W. K. Reisen acknowledges support from the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate, Department of Homeland Security and Fogarty International Center, National Institutes of Health. NR 85 TC 7 Z9 8 U1 0 U2 19 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1168 EP 1178 DI 10.4269/ajtmh.13-0219 PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100018 PM 24043690 ER PT J AU Edupuganti, S Mulligan, MJ Eidex, RB Cetron, M Marfin, AA AF Edupuganti, Srilatha Mulligan, Mark J. Eidex, Rachel B. Cetron, Martin Marfin, Anthony A. TI 17D Yellow Fever Virus Vaccine Response SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Letter ID ANTIBODIES; TRIAL C1 [Edupuganti, Srilatha; Mulligan, Mark J.] Emory Univ, Sch Med, Atlanta, GA 30332 USA. [Eidex, Rachel B.; Cetron, Martin; Marfin, Anthony A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Edupuganti, S (reprint author), Emory Univ, Sch Med, Atlanta, GA 30332 USA. EM mark.mulligan@emory.edu NR 12 TC 1 Z9 1 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1226 EP 1227 DI 10.4269/ajtmh.13-0443b PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100030 PM 24306032 ER PT J AU Hodge, DR Prentice, KW Ramage, JG Prezioso, S Gauthier, C Swanson, T Hastings, R Basavanna, U Datta, S Sharma, SK Garber, EAE Staab, A Pettit, D Drumgoole, R Swaney, E Estacio, PL Elder, IA Kovacs, G Morse, BS Kellogg, RB Stanker, L Morse, SA Pillai, SP AF Hodge, David R. Prentice, Kristin Willner Ramage, Jason G. Prezioso, Samantha Gauthier, Cheryl Swanson, Tanya Hastings, Rebecca Basavanna, Uma Datta, Shomik Sharma, Shashi K. Garber, Eric A. E. Staab, Andrea Pettit, Denise Drumgoole, Rahsaan Swaney, Erin Estacio, Peter L. Elder, Ian A. Kovacs, Gerald Morse, Brenda S. Kellogg, Richard B. Stanker, Larry Morse, Stephen A. Pillai, Segaran P. TI COMPREHENSIVE LABORATORY EVALUATION OF A HIGHLY SPECIFIC LATERAL FLOW ASSAY FOR THE PRESUMPTIVE IDENTIFICATION OF RICIN IN SUSPICIOUS WHITE POWDERS AND ENVIRONMENTAL SAMPLES SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID RIBOSOME-INACTIVATING PROTEINS; COMMUNIS AGGLUTININ; CASTOR BEANS; TOXINS; GENE; SEQUENCE; AGENTS; CHAIN; ELECTROCHEMILUMINESCENCE; CYTOTOXICITY AB Ricin, a heterodimeric toxin that is present in the seeds of the Ricinus communis plant, is the biothreat agent most frequently encountered by law enforcement agencies in the United States. Even in untrained hands, the easily obtainable seeds can yield a highly toxic product that has been used in various types of threats, including white-powder letters. Although the vast majority of these threats are hoaxes, an impediment to accurate hazard assessments by first responders is the unreliability of rapid detection assays for ricin, such as lateral flow assays (LFAs). One of the complicating factors associated with LFAs is the incorporation of antibodies of poor specificity that cross-react with near-neighbors or with plant lectins that are capable of nonspecifically cross-linking the capture and detector antibodies. Because of the compelling and critical need to promote the interests of public safety and public health, the Department of Homeland Security conducted a comprehensive laboratory evaluation study of a commercial LFA for the rapid detection of ricin. This study was conducted using comprehensive inclusivity and exclusivity panels of ricin and near-neighbor plant materials, along with panels of lectins and white-powders, to determine the specificity, sensitivity, limits of detection, dynamic range, and repeatability of the assay for the specific intended use of evaluating suspicious white powders and environmental samples in the field. C1 [Hodge, David R.; Prentice, Kristin Willner] Booz Allen & Hamilton Inc, Mclean, VA 22102 USA. [Ramage, Jason G.; Pillai, Segaran P.] US Dept Homeland Secur, Sci & Technol Directorate, Chem & Biol Def Div, Washington, DC USA. [Prezioso, Samantha] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Gauthier, Cheryl; Swanson, Tanya; Hastings, Rebecca] Massachusetts Dept Publ Hlth, Bioterrorism Response Lab, State Lab Inst, Jamaica Plain, MA USA. [Basavanna, Uma] USAMRIID, Ft Detrick, MD USA. [Datta, Shomik; Sharma, Shashi K.; Garber, Eric A. E.] Food & Drug Adm, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, College Pk, MD USA. [Pettit, Denise] NC Dept Hlth & Human Serv, North Carolina State Lab Publ Hlth, Raleigh, NC USA. [Drumgoole, Rahsaan; Swaney, Erin] Texas Dept State Hlth Serv, Emergency Preparedness Branch, Austin, TX USA. [Estacio, Peter L.] Lawrence Livermore Natl Lab, Environm Hlth & Qual Assurance, Livermore, CA USA. [Elder, Ian A.] US Dept Homeland Secur, Washington, DC USA. [Morse, Brenda S.; Kellogg, Richard B.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Preparedness & Emerging Infect, Lab Preparedness & Response Branch, Atlanta, GA 30333 USA. [Stanker, Larry] USDA ARS, Foodborne Toxin Detect & Prevent Res Unit, Albany, CA USA. [Morse, Stephen A.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Hodge, DR (reprint author), Dept Homeland Secur, S&T BOD STOP 0201,245 Murray Lane, Washington, DC 20528 USA. EM David.Hodge@hq.dhs.gov NR 52 TC 13 Z9 13 U1 1 U2 12 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 EI 1557-850X J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC 1 PY 2013 VL 11 IS 4 BP 237 EP 250 DI 10.1089/bsp.2013.0053 PG 14 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 276KT UT WOS:000328749900003 PM 24320219 ER PT J AU Sobelson, RK Young, AC Marcus, LJ Dorn, BC Neslund, VS McNulty, EJ AF Sobelson, Robyn K. Young, Andrea C. Marcus, Leonard J. Dorn, Barry C. Neslund, Verla S. McNulty, Eric J. TI THE META-LEADERSHIP SUMMIT FOR PREPAREDNESS INITIATIVE: AN INNOVATIVE MODEL TO ADVANCE PUBLIC HEALTH PREPAREDNESS AND RESPONSE SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID EMERGENCY MANAGEMENT; TOOL AB This article reports on the design, evaluation framework, and results from the Meta-Leadership Summit for Preparedness Initiative. The Meta-Leadership Summit for Preparedness was a 5-year initiative based on the premise that national preparedness and emergency response is not solely the responsibility of government. From 2006 to 2011, 36 Meta-Leadership Summits were delivered in communities across the country. Summits were customized, 10-hour leadership development, networking, and community action planning events. They included participation from targeted federal, state, local, nonprofit/philanthropic, and private sector leaders who are directly involved in decision making during a major community or state-wide emergency. A total of 4,971 government, nonprofit, and business leaders attended Meta-Leadership Summits; distribution of attendees by sector was balanced. Ninety-three percent of respondents reported the summit was a valuable use of time, 91% reported the overall quality as good or outstanding, and 91% would recommend the summit to their colleagues. In addition, approximately 6 months after attending a summit, 80% of respondents reported that they had used meta-leadership concepts or principles. Of these, 93% reported that using meta-leadership concepts or principles had made a positive difference for them and their organizations. The Meta-Leadership Summit for Preparedness Initiative was a value-added opportunity for communities, providing the venue for learning the concepts and practice of meta-leadership, multisector collaboration, and resource sharing with the intent of substantively improving preparedness, response, and recovery efforts. C1 [Sobelson, Robyn K.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA 30329 USA. [Young, Andrea C.] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Atlanta, GA 30329 USA. [Marcus, Leonard J.] Harvard Univ, Sch Publ Hlth, Natl Preparedness Leadership Initiat, Cambridge, MA 02138 USA. [McNulty, Eric J.] Harvard Univ, Sch Publ Hlth, NPLI, Res Program, Cambridge, MA 02138 USA. [McNulty, Eric J.] Harvard Univ, Sch Publ Hlth, NPLI, Profess Program, Cambridge, MA 02138 USA. [Dorn, Barry C.] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA. [Neslund, Verla S.] CDC Fdn, Atlanta, GA USA. RP Sobelson, RK (reprint author), Ctr Dis Control & Prevent, Learning Off, Off Publ Hlth Preparedness & Response, 1600 Clifton Rd,NE,MS D-44, Atlanta, GA 30329 USA. EM rsobelson@cdc.gov NR 24 TC 1 Z9 1 U1 0 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 EI 1557-850X J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC 1 PY 2013 VL 11 IS 4 BP 251 EP 261 DI 10.1089/bsp.2013.0056 PG 11 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 276KT UT WOS:000328749900004 PM 24251597 ER PT J AU Posid, JM Bruce, SM Guarnizo, JT O'Connor, RC Papagiotas, SS Taylor, ML AF Posid, Joseph M. Bruce, Sherrie M. Guarnizo, Julie T. O'Connor, Ralph C., Jr. Papagiotas, Stephen S. Taylor, Melissa L. TI PUBLIC HEALTH EMERGENCIES AND RESPONSES: WHAT ARE THEY, HOW LONG DO THEY LAST, AND HOW MANY STAFF DOES YOUR AGENCY NEED? SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID FUTURE; SARS AB Responding to outbreaks is one of the most routine yet most important functions of a public health agency. However, some outbreaks are bigger, more visible, or more complex than others, prompting discussion about when an outbreak becomes a public health emergency. When a public health emergency is identified, resources (eg, funding, staff, space) may need to be redirected from core public health programs to contribute to the public health emergency response. The need to sustain critical public health functions while preparing for public health emergency responses raises a series of operational and resource management questions, including when a public health emergency begins and ends, why additional resources are needed, how long an organization should expect staff to be redirected, and how many staff (or what proportion of the agency's staff) an organization should anticipate will be needed to conduct a public health emergency response. This article addresses these questions from a national perspective by reviewing events for which the Centers for Disease Control and Prevention redirected staff from core public health functions to respond to a series of public health emergencies. We defined public health emergency in both operational and public health terms and found that on average each emergency response lasted approximately 4 months and used approximately 9.5% of our workforce. We also provide reasons why public health agencies should consider the impact of redirecting resources when preparing for public health emergencies. C1 [Posid, Joseph M.; Bruce, Sherrie M.; Guarnizo, Julie T.; Papagiotas, Stephen S.; Taylor, Melissa L.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Preparedness & Emerging Infect, Atlanta, GA 30333 USA. [O'Connor, Ralph C., Jr.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Div Emergency Operat, Atlanta, GA 30333 USA. RP Posid, JM (reprint author), Ctr Dis Control & Prevent, NCEZID DPEI, 1600 Clifton Rd,MS C-18, Atlanta, GA 30333 USA. EM jmp2@cdc.gov NR 14 TC 0 Z9 0 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 EI 1557-850X J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC 1 PY 2013 VL 11 IS 4 BP 271 EP 279 DI 10.1089/bsp.2013.0044 PG 9 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 276KT UT WOS:000328749900006 PM 24219494 ER PT J AU Allen, JA Longenecker, HB Perrine, CG Scanlon, KS AF Allen, Jessica A. Longenecker, Holly B. Perrine, Cria G. Scanlon, Kelley S. TI Baby-Friendly Hospital Practices and Birth Costs SO BIRTH-ISSUES IN PERINATAL CARE LA English DT Article DE breastfeeding; maternity care practices; birth costs ID UNITED-STATES AB Background: Hospital practices supportive of breastfeeding can improve breastfeeding rates. There are limited data available on how improved hospital practices are associated with hospital costs. We describe the association between the number of breastfeeding supportive practices a hospital has in place and the cost of an uncomplicated birth. Methods: Data from hospitals in 20 states that participated in the 2007 Maternity Practices in Infant Nutrition and Care (mPINC) survey and Healthcare Cost and Utilization Project's (HCUP) State Inpatient Databases (SID) were merged to calculate the average median hospital cost of uncomplicated vaginal and cesarean section births by number of ideal practices from the Ten Steps to Successful Breastfeeding. Linear regression analyses were conducted to estimate change in birth cost for each additional ideal practice in place. Results: Sixty-one percent of hospitals had ideal practice on 3-5 of the 10 steps, whereas 29 percent of hospitals had ideal practice on 6-8. Adjusted analyses of uncomplicated births revealed a higher but nonsignificant increase in any of the birth categories (all births, $19; vaginal, $15; cesarean section, $39) with each additional breastfeeding supportive maternity care practice in place. Conclusions: Our results revealed that the number of breastfeeding supportive practices a hospital has in place is not significantly associated with higher birth costs. Concern for higher birth costs should not be a barrier for improving maternity care practices that support women who choose to breastfeed. (BIRTH 40: 4 December 2013) C1 [Allen, Jessica A.; Perrine, Cria G.; Scanlon, Kelley S.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. [Longenecker, Holly B.] Northrop Grumman Corp, Atlanta, GA USA. RP Allen, JA (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F-77, Atlanta, GA 30341 USA. FU Intramural CDC HHS [CC999999]; NIDDK NIH HHS [T32 DK007734] NR 26 TC 1 Z9 1 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7659 EI 1523-536X J9 BIRTH-ISS PERINAT C JI Birth-Issue Perinat. Care PD DEC PY 2013 VL 40 IS 4 BP 221 EP 226 DI 10.1111/birt.12062 PG 6 WC Nursing; Obstetrics & Gynecology; Pediatrics SC Nursing; Obstetrics & Gynecology; Pediatrics GA 274CK UT WOS:000328582500004 PM 24344702 ER PT J AU Rainey, JJ Sugerman, D Brennan, M Cadet, JR Ernsly, J Lacapere, F Danovaro-Holliday, MC Mubalama, JC Nandy, R AF Rainey, Jeanette J. Sugerman, David Brennan, Muireann Cadet, Jean Ronald Ernsly, Jackson Lacapere, Francois Danovaro-Holliday, M. Carolina Mubalama, Jean-Claude Nandy, Robin TI Rapid monitoring in vaccination campaigns during emergencies: the post-earthquake campaign in Haiti SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID AMERICA AB Problem The earthquake that struck Haiti in January 2010 caused 1.5 million people to be displaced to temporary camps. The Haitian Ministry of Public Health and Population and global immunization partners developed a plan to deliver vaccines to those residing in these camps. A strategy was needed to determine whether the immunization targets set for the campaign were achieved. Approach Following the vaccination campaign, staff from the Ministry of Public Health and Population interviewed convenience samples of households in specific predetermined locations in each of the camps-regarding receipt of the emergency vaccinations. A camp was targeted for "mop-up vaccination" i.e. repeat mass vaccination if more than 25% of the children aged 9 months to 7 years in the sample were found not to have received the emergency vaccinations. Local setting Rapid monitoring was implemented in camps located in the Port-au-Prince metropolitan area. Camps that housed more than 5000 people were monitored first. Relevant changes By the end of March 2010, 72 (23%) of the 310 vaccinated camps had been monitored. Although 32 (44%) of the monitored camps were targeted for mop-up vaccination, only six of them had received such repeat mass vaccination when checked several weeks after monitoring. Lessons learnt Rapid, monitoring was only marginally beneficial in achieving immunization targets in the temporary camps in Port-au-Prince. More research is needed to evaluate the utility of conventional rapid monitoring, as well as other strategies, during post-disaster vaccination campaigns that involve mobile populations, particularly when there is little capacity to conduct repeat mass vaccination. C1 [Rainey, Jeanette J.; Sugerman, David] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. [Brennan, Muireann] Ctr Dis Control & Prevent, Int Emergency & Refugee Hlth Branch, Atlanta, GA 30333 USA. [Cadet, Jean Ronald] Minist Publ Hlth & Populat, Expanded Programme Immunizat, Port Au Prince, Haiti. [Ernsly, Jackson; Mubalama, Jean-Claude] United Nations Childrens Fund, Hlth Sect, Port Au Prince, Haiti. [Lacapere, Francois] Pan Amer Hlth Org, Expanded Programme Immunizat, Port Au Prince, Haiti. [Danovaro-Holliday, M. Carolina] Pan Amer Hlth Org, Comprehens Family Immunizat, Washington, DC USA. [Nandy, Robin] United Nations Childrens Fund, Hlth Sect, New York, NY USA. RP Rainey, JJ (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, 1600 Clifton Rd,MS E-05, Atlanta, GA 30333 USA. EM jkr7@cdc.gov NR 10 TC 0 Z9 0 U1 0 U2 7 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 EI 1564-0604 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD DEC PY 2013 VL 91 IS 12 BP 957 EP 962 DI 10.2471/BLT.12.117044 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 275XT UT WOS:000328713400016 PM 24347735 ER PT J AU Bass, J Tack, DM McCollum, AM Kabamba, J Pakuta, E Malekani, J Nguete, B Monroe, BP Doty, JB Karhemere, S Damon, IK Balilo, M Okitolonda, E Shongo, RL Reynolds, MG AF Bass, Jennifer Tack, Danielle M. McCollum, Andrea M. Kabamba, Joelle Pakuta, Elisabeth Malekani, Jean Nguete, Beatrice Monroe, Benjamin P. Doty, Jeffrey B. Karhemere, Stomy Damon, Inger K. Balilo, Marcel Okitolonda, Emile Shongo, Robert L. Reynolds, Mary G. TI Enhancing health care worker ability to detect and care for patients with monkeypox in the Democratic Republic of the Congo SO INTERNATIONAL HEALTH LA English DT Article DE Monkeypox; PCR; Surveillance; Training evaluation; Zoonosis ID VIRUS; TRANSMISSION; SMALLPOX; SURVEILLANCE; OUTBREAK; FEATURES AB Monkeypox (MPX) is an endemic disease of public health importance in the Democratic Republic of the Congo (DRC). In 2010, the DRC Ministry of Health joined with external partners to improve MPX surveillance in the Tshuapa Health District of DRC. A pivotal component of the program is training of health zone personnel in surveillance methods and patient care. In this report we evaluate outcomes of the training program. Health care worker knowledge of key concepts in the MPX training curriculum was assessed using an anonymous self-administered survey. Additionally, evaluators collected feedback about the capacity of participants to perform the surveillance tasks. Training impacts were determined by assessing various surveillance performance metrics. Correct trainee responses to questions about MPX symptoms and patient care increased significantly upon completion of training events. During the 12 months after the initial training, the proportion of suspected cases investigated increased significantly (from 6.7 to 37.3), as compared to the 5 months prior. However, the proportion of reported cases that were ultimately confirmed remained unchanged, 20.1 (5/24) vs 23.3 (60/257). We have demonstrated that the MPX curriculum developed for this initiative was effective in transferring knowledge and was associated with improved detection of human MPX cases. C1 [Bass, Jennifer; McCollum, Andrea M.; Monroe, Benjamin P.; Doty, Jeffrey B.; Damon, Inger K.; Reynolds, Mary G.] US Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. [Tack, Danielle M.] US Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Kabamba, Joelle] US Ctr Dis Control & Prevent, Country Operat Branch, Kinshasa, Zaire. [Pakuta, Elisabeth; Karhemere, Stomy] Minist Hlth, Natl Inst Biomed Res, Kinshasa, Zaire. [Malekani, Jean] Univ Kinshasa, Dept Biol Sci, Kinshasa, Zaire. [Okitolonda, Emile] Univ Kinshasa, Ctr HIV AIDS Strateg Informat, Kinshasa, Zaire. [Balilo, Marcel; Shongo, Robert L.] Minist Hlth, Hemorrhag Fever & Monkeypox Program, Kinshasa, Zaire. RP Reynolds, MG (reprint author), US Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. EM nzr6@cdc.gov FU US Centers for Disease Control and Prevention FX This work was funded by the US Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the funding agency. NR 23 TC 1 Z9 1 U1 1 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1876-3413 EI 1876-3405 J9 INT HEALTH JI Int. Health PD DEC PY 2013 VL 5 IS 4 BP 237 EP 243 DI 10.1093/inthealth/iht029 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 271BH UT WOS:000328364800001 PM 24246742 ER EF