FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Preston, RJ
AF Preston, R. Julian
TI INTEGRATING BASIC RADIOBIOLOGICAL SCIENCE AND EPIDEMIOLOGICAL STUDIES:
WHY AND HOW
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; biological
indicators; epidemiology; risk analysis
ID DOSE-RESPONSE; IONIZING-RADIATION; RISK-ASSESSMENT; KEY EVENTS;
INCIDENCE CURVES; HEALTH-RISKS; CANCER-RISKS; EXPOSURE; MODE; CHILDHOOD
AB There is quite an extensive set of epidemiology studies conducted for a range of different radiation exposure scenarios and in some cases at doses that can be considered to be in the low dose range (< 100 mGy). In addition, there is an extensive literature on the effects of radiation at animal and cellular levels, as well as expanding knowledge of the underlying mechanisms of disease formation (both cancer and non-cancer). A significant concern is that these two areas of study have been linked rarely to support each other-to enhance low dose/low dose-rate extrapolation and reduction of uncertainty in risk estimates. Research should provide specific types of data to support the epidemiology and thereby enhance the radiation risk assessment process. Such an approach is one that can be adapted from that used for chemical exposures. It is based on the concept of adverse outcome pathways for the formation of adverse health outcomes. The adverse outcome pathway conceptual framework is considered to be a logical sequence of events (so-called key events) or processes within biological systems that can be used to understand adverse effects and refine the current risk assessment practice. This approach, which has only been used currently for chemicals, shifts the risk assessment focus from traditional apical endpoints (e.g., cancer and cardiovascular disease) to the development of a mechanistic understanding of effects at a molecular and cellular level. The need is to further the knowledge of the key events in radiation-induced diseases and to provide information on the dose and dose-rate response for these. It is proposed that the key-event approach be used in conjunction with enhanced radiation epidemiology data to reduce overall uncertainty in low dose/low dose-rate cancer and non-cancer risk estimates.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Preston, RJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM preston.julian@epa.gov
NR 42
TC 8
Z9 8
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 125
EP 130
DI 10.1097/HP.0000000000000224
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100007
PM 25551492
ER
PT J
AU Simon, SL
Braby, LA
Chang, PY
Goodhead, DT
Hora, S
Kocher, DC
Mabuchi, K
Puskin, JS
Richardson, D
Rosenstein, M
Tucker, J
Vano, E
AF Simon, Steven L.
Braby, Leslie A.
Chang, Polly Y.
Goodhead, Dudley T.
Hora, Stephen
Kocher, David C.
Mabuchi, Kiyohiko
Puskin, Jerome S.
Richardson, David
Rosenstein, Marvin
Tucker, James
Vano, Eliseo
TI BIOLOGICAL EFFECTIVENESS OF PHOTONS AND ELECTRONS AS A FUNCTION OF
ENERGY
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; cancer;
radiation risk; relative biological effectiveness
C1 [Simon, Steven L.; Mabuchi, Kiyohiko] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Braby, Leslie A.] Texas A&M Univ, Dept Nucl Engn, College Stn, TX 77843 USA.
[Chang, Polly Y.] SRI Int, Menlo Pk, CA 94025 USA.
[Goodhead, Dudley T.] MRC, Harwell OX11 0RD, Berks, England.
[Hora, Stephen] Univ So Calif, Ctr Risk & Econ Anal Terrorism Events, Los Angeles, CA 90089 USA.
[Kocher, David C.] Oak Ridge Ctr Risk Anal, Oak Ridge, TN 37830 USA.
[Puskin, Jerome S.] US EPA, Washington, DC 20460 USA.
[Richardson, David] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
[Tucker, James] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA.
[Vano, Eliseo] Univ Complutense, Dept Radiol, Sch Med, E-28040 Madrid, Spain.
RP Simon, SL (reprint author), NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
EM ssimon@mail.nih.gov
NR 3
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 143
EP 144
DI 10.1097/HP.0000000000000256
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100009
PM 25551494
ER
PT J
AU Boyd, MA
AF Boyd, Michael A.
TI US RADIATION PROTECTION: ROLE OF NATIONAL AND INTERNATIONAL
RECOMMENDATIONS AND OPPORTUNITIES FOR COLLABORATION (HARMONY, NOT
DISSONANCE)
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; International
Commission on Radiological Protection; radiation protection; safety
standards
AB For much of the 20th century, U.S. radiation protection policies were similar to those elsewhere in the world, in large part because the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) were closely aligned. In the 1970s, several U.S. regulations were released at about the same time as the 1977 recommendations from ICRP. The regulatory development process in the United States can be lengthy with ample opportunities for public involvement. While such deliberation is essential and beneficial, the rulemaking process does not lend itself to making frequent technical updates to rules. For this reason, many of the current radiation protection regulations in the United States are out of step with current recommendations of the ICRP and NCRP. The U.S. Nuclear Regulatory Commission and the U.S. Environmental Protection Agency are considering updates to important radiation protection regulations. These regulatory development actions could present the United States with an opportunity for incorporating the latest science into the U.S. system of radiation protection and provide for consideration of the latest recommendations of ICRP and NCRP. In particular, a revision of the recommendations in NCRP Report No. 116 (Limitation of Exposure to Ionizing Radiation) could provide U.S. agencies with useful advice to be considered in these rulemakings.
C1 US EPA, Washington, DC 20460 USA.
RP Boyd, MA (reprint author), US EPA, Ariel Rios Bldg,Mail Code 6608J,1200 Penn Ave NW, Washington, DC 20460 USA.
EM boyd.mike@epa.gov
NR 22
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 278
EP 282
DI 10.1097/HP.0000000000000236
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100024
PM 25551510
ER
PT J
AU Cyphert, JM
Carlin, DJ
Nyska, A
Schladweiler, MC
Ledbetter, AD
Shannahan, JH
Kodavanti, UP
Gavett, SH
AF Cyphert, Jaime M.
Carlin, Danielle J.
Nyska, Abraham
Schladweiler, Mette C.
Ledbetter, Allen D.
Shannahan, Jonathan H.
Kodavanti, Urmila P.
Gavett, Stephen H.
TI Comparative Long-Term Toxicity of Libby Amphibole and Amosite Asbestos
in Rats After Single or Multiple Intratracheal Exposures
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID FISCHER-344 RATS; MALIGNANT MESOTHELIOMA; MONTANA; VERMICULITE; DISEASE;
LUNG; FERROACTINOLITE; CARCINOGENICITY; INSTILLATION; INHALATION
AB In former mine workers of Libby, MT, exposure to amphibole-containing vermiculite was linked to increased rates of asbestosis, lung cancer, and mesothelioma. Although many studies showed adverse effects following exposure to Libby amphibole (LA; a mixture of winchite, richterite, and tremolite), little is known regarding the relative toxicity of LA compared to regulated asbestos, or regarding the risks associated with acute high-dose exposures relative to repeated low-dose exposures. In this study, pulmonary function, inflammation, and pathology were assessed after single or multiple intratracheal (IT) exposures of LA or a well-characterized amosite (AM) control fiber with equivalent fiber characteristics. Male F344 rats were exposed to an equivalent total mass dose (0.15, 0.5, 1.5, or 5 mg/rat) of LA or AM administered either as a single IT instillation, or as multiple IT instillations given every other week over a 13-wk period, and necropsied up to 20 mo after the initial IT. When comparing the two fiber types, in both studies LA resulted in greater acute neutrophilic inflammation and cellular toxicity than equal doses of AM, but long-term histopathological changes were approximately equivalent between fibers, suggesting that LA is at least as toxic as AM. In addition, although no dose-response relationship was discerned, mesothelioma or lung carcinomas were found after exposure to low and high dose levels of LA or AM in both studies. Conversely, when comparing studies, an equal mass dose given over multiple exposures instead of a single bolus resulted in greater chronic pathological changes in lung at lower doses, despite the initially weaker acute inflammatory response. Overall, these results suggest that there is a possibility of greater long-term pathological changes with repeated lower LA dose exposures, which more accurately simulates chronic environmental exposures.
C1 [Cyphert, Jaime M.] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC USA.
[Cyphert, Jaime M.; Carlin, Danielle J.; Nyska, Abraham] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Timrat, Israel.
[Schladweiler, Mette C.; Ledbetter, Allen D.; Kodavanti, Urmila P.; Gavett, Stephen H.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Shannahan, Jonathan H.] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO USA.
RP Gavett, SH (reprint author), US EPA, DABT, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Gavett.stephen@epa.gov
FU U.S. EPA/University of North Carolina Toxicology Research Program
Training Agreement [CR 933237, 83515201-0]
FX This work was supported by a U.S. EPA/University of North Carolina
Toxicology Research Program Training Agreement (CR 933237 and
83515201-0). The authors thank Judy Richards for assistance with
biochemical analysis, and Drs. David Berry, Ian Gilmour, Maureen Gwinn,
Gary Hatch, and Ronald Hines for manuscript review.
NR 35
TC 7
Z9 7
U1 2
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD FEB 1
PY 2015
VL 78
IS 3
BP 151
EP 165
DI 10.1080/15287394.2014.947455
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AW5YC
UT WOS:000346345800001
PM 25506632
ER
PT J
AU Hu, L
Montzka, SA
Miller, JB
Andrews, AE
Lehman, SJ
Miller, BR
Thoning, K
Sweeney, C
Chen, HL
Godwin, DS
Masarie, K
Bruhwiler, L
Fischer, ML
Biraud, SC
Torn, MS
Mountain, M
Nehrkorn, T
Eluszkiewicz, J
Miller, S
Draxler, RR
Stein, AF
Hall, BD
Elkins, JW
Tans, PP
AF Hu, Lei
Montzka, Stephen A.
Miller, John B.
Andrews, Aryln E.
Lehman, Scott J.
Miller, Benjamin R.
Thoning, Kirk
Sweeney, Colm
Chen, Huilin
Godwin, David S.
Masarie, Kenneth
Bruhwiler, Lori
Fischer, Marc L.
Biraud, Sebastien C.
Torn, Margaret S.
Mountain, Marikate
Nehrkorn, Thomas
Eluszkiewicz, Janusz
Miller, Scot
Draxler, Roland R.
Stein, Ariel F.
Hall, Bradley D.
Elkins, James W.
Tans, Pieter P.
TI US emissions of HFC-134a derived for 2008-2012 from an extensive
flask-air sampling network
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
DE HFC-134a; emissions; inverse modeling; atmosphere based; US
ID ATMOSPHERIC OBSERVATIONS; EUROPEAN EMISSIONS; TRANSPORT MODELS; GLOBAL
EMISSIONS; INVERSION METHOD; UNITED-STATES; STILT MODEL; PART 1; CO2;
PERSPECTIVE
AB U.S. national and regional emissions of HFC-134a are derived for 2008-2012 based on atmospheric observations from ground and aircraft sites across the U.S. and a newly developed regional inverse model. Synthetic data experiments were first conducted to optimize the model assimilation design and to assess model-data mismatch errors and prior flux error covariances computed using a maximum likelihood estimation technique. The synthetic data experiments also tested the sensitivity of derived national and regional emissions to a range of assumed prior emissions, with the goal of designing a system that was minimally reliant on the prior. We then explored the influence of additional sources of error in inversions with actual observations, such as those associated with background mole fractions and transport uncertainties. Estimated emissions of HFC-134a range from 52 to 61 Gg yr(-1) for the contiguous U.S. during 2008-2012 for inversions using air transport from Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model driven by the 12km resolution meteorogical data from North American Mesoscale Forecast System (NAM12) and all tested combinations of prior emissions and background mole fractions. Estimated emissions for 2008-2010 were 20% lower when specifying alternative transport from Stochastic Time-Inverted Lagrangian Transport (STILT) model driven by the Weather Research and Forecasting (WRF) meteorology. Our estimates (for HYSPLIT-NAM12) are consistent with annual emissions reported by U.S. Environmental Protection Agency for the full study interval. The results suggest a 10-20% drop in U.S. national HFC-134a emission in 2009 coincident with a reduction in transportation-related fossil fuel CO2 emissions, perhaps related to the economic recession. All inversions show seasonal variation in national HFC-134a emissions in all years, with summer emissions greater than winter emissions by 20-50%.
C1 [Hu, Lei; Miller, John B.; Miller, Benjamin R.; Sweeney, Colm] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[Hu, Lei; Montzka, Stephen A.; Miller, John B.; Andrews, Aryln E.; Miller, Benjamin R.; Thoning, Kirk; Sweeney, Colm; Masarie, Kenneth; Bruhwiler, Lori; Hall, Bradley D.; Elkins, James W.; Tans, Pieter P.] NOAA, Global Monitoring Div, Earth Syst Res Lab, Boulder, CO USA.
[Lehman, Scott J.] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA.
[Chen, Huilin] Univ Groningen, Ctr Isotope Res, Groningen, Netherlands.
[Godwin, David S.] US EPA, Alternat & Emiss Reduct Branch, Stratospher Protect Div, Off Atmospher Programs,Off Air & Radiat, Washington, DC 20460 USA.
[Fischer, Marc L.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA.
[Biraud, Sebastien C.; Torn, Margaret S.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA.
[Mountain, Marikate; Nehrkorn, Thomas; Eluszkiewicz, Janusz] Atmospher & Environm Res, Lexington, MA USA.
[Miller, Scot] Harvard Univ, Dept Earth & Planetary Sci, Cambridge, MA 02138 USA.
[Draxler, Roland R.; Stein, Ariel F.] NOAA, Air Resources Lab, College Pk, MD USA.
RP Hu, L (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
EM lei.hu@colorado.edu; stephen.a.montzka@noaa.gov
RI Torn, Margaret/D-2305-2015; Andrews, Arlyn/K-3427-2012; Chen,
Huilin/J-9479-2012; Stein, Ariel F/L-9724-2014; Biraud,
Sebastien/M-5267-2013
OI Chen, Huilin/0000-0002-1573-6673; Stein, Ariel F/0000-0002-9560-9198;
Montzka, Stephen/0000-0002-9396-0400; Nehrkorn,
Thomas/0000-0003-0637-3468; Biraud, Sebastien/0000-0001-7697-933X
FU NOAA Climate Program Office's Atmospheric Chemistry, Carbon Cycle, and
Climate (AC4) program - North American Carbon Program; California Energy
Commission; California Air Resources Board [DE-AC02-05CH11231]; U.S.
Department of Energy, Office of Science, Atmospheric Radiation
Measurement Program [DE-AC02-05CH11231]; U.S. Department of Energy,
Office of Science, Office of Biological and Environmental Research
[DE-AC02-05CH11231]; NOAA's Climate Program Office under the
CarbonTracker-Lagrange project
FX This work was performed while one of us (LH) was a National Research
Council postdoctoral fellow and was funded in part by NOAA Climate
Program Office's Atmospheric Chemistry, Carbon Cycle, and Climate (AC4)
program in support of the North American Carbon Program. Flask sampling
at the WGC and STR towers were partially supported by a California
Energy Commission and the California Air Resources Board grants to LBNL
under contract DE-AC02-05CH11231, while aircraft sampling above the SGP
site was supported by the U.S. Department of Energy, Office of Science,
Atmospheric Radiation Measurement Program and Office of Biological and
Environmental Research, both underx U.S. Department of Energy contract
DE-AC02-05CH11231. WRF-STILT runs were supported by NOAA's Climate
Program Office under the CarbonTracker-Lagrange project. This inversion
analysis was conducted using the high performance computing system in
the NOAA Environmental Security Computing Center, located in Fairmont,
West Virginia, USA. We thank A. Jacobson and S. Basu for useful
discussions related to inversion problems. We thank C. Siso, D. Mondeel,
P. M. Lang, J. Higgs, M. Crotwell, S. Wolter, D. Neff, J. Kofler, and
others involved with flask analysis and the large team of collaborators
associated with operation, maintenance, and logistics of NOAA's
Cooperative U.S.- and global-scale Greenhouse Gas Reference flask
sampling networks. Measured atmospheric mole fractions of HFC-134a and
calculated footprints used in this analysis can be downloaded at
NOAA/ESRL/GMD website
(http://www.esrl.noaa.gov/gmd/hats/gases/HFC134a.html).
NR 68
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U1 2
U2 16
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JAN 27
PY 2015
VL 120
IS 2
BP 801
EP 825
DI 10.1002/2014JD022617
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CC1QQ
UT WOS:000350117100026
ER
PT J
AU Willson, SA
AF Willson, Stuart A.
TI Investigation of the Persistence of Nerve Agent Degradation Analytes on
Surfaces through Wipe Sampling and Detection with Ultrahigh Performance
Liquid Chromatography-Tandem Mass Spectrometry
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID CHEMICAL WARFARE AGENTS; HYDROLYSIS PRODUCTS; PESTICIDES; MATRICES;
SARIN; FATE; VX
AB The persistence of chemical warfare nerve agent degradation analytes on surfaces is important, from indicating the presence of nerve agent on a surface to guiding environmental restoration of a site after a release. Persistence was investigated for several chemical warfare nerve agent degradation analytes on indoor surfaces and presents an approach for wipe sampling of surfaces, followed by wipe extraction and liquid chromatographytandem mass spectrometry detection. Commercially available wipe materials were investigated to determine optimal wipe recoveries. Tested surfaces included porous/permeable (vinyl tile, painted drywall, and wood) and largely nonporous/impermeable (laminate, galvanized steel, and glass) surfaces. Wipe extracts were analyzed by ultrahigh performance liquid chromatographytandem mass spectrometry (UPLCMS/MS). UPLC provides a separation of targeted degradation analytes in addition to being nearly four times faster than high-performance liquid chromatography, allowing for greater throughput after a large-scale contamination incident and subsequent remediation events. Percent recoveries from nonporous/impermeable surfaces were 60103% for isopropyl methylphosphonate (IMPA), GB degradate; 6191% for ethyl methylphosphonate (EMPA), VX degradate; and 6098% for pinacolyl methylphosphonate (PMPA), GD degradate. Recovery efficiencies for methyl phosphonate (MPA), nerve agent degradate, and ethylhydrogen dimethylphosphonate (EHDMAP), GA degradate, were lower, perhaps due to matrix effects. Diisopropyl methylphosphonate, GB impurity, was not recovered from surfaces. The resulting detection limits for wipe extracts were 0.065 ng/cm(2) for IMPA, 0.079 ng/cm(2) for MPA, 0.040 ng/cm(2) for EMPA, 0.078 ng/cm(2) for EHDMAP, and 0.013 ng/cm(2) for PMPA. The data indicate that laboratories may hold wipe samples for up to 30 days prior to analysis. Target analytes were observed to persist on surfaces for at least 6 weeks.
C1 US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Willson, SA (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
EM Willison.stuart@epa.gov
FU U.S. Environmental Protection Agency (EPA) through Office of Research
and Development under EPA IA [DW-75-922440001-0]; National Institute for
Occupational Safety and Health (NIOSH) through Centers for Disease
Control and Prevention
FX The U.S. Environmental Protection Agency (EPA) through its Office of
Research and Development funded and managed the research described
herein under EPA IA no. DW-75-922440001-0 with the National Institute
for Occupational Safety and Health (NIOSH) through its Centers for
Disease Control and Prevention. It has been reviewed by the Agency but
does not necessarily reflect the Agency's views. No official endorsement
should be inferred. EPA does not endorse the purchase or sale of any
commercial products or services.
NR 35
TC 3
Z9 3
U1 3
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD JAN 20
PY 2015
VL 87
IS 2
BP 1034
EP 1041
DI 10.1021/ac503777z
PG 8
WC Chemistry, Analytical
SC Chemistry
GA AZ6LX
UT WOS:000348332300030
PM 25495198
ER
PT J
AU Sekine, R
Brunetti, G
Donner, E
Khaksar, M
Vasilev, K
Jamting, AK
Scheckel, KG
Kappen, P
Zhang, H
Lombi, E
AF Sekine, R.
Brunetti, G.
Donner, E.
Khaksar, M.
Vasilev, K.
Jaemting, A. K.
Scheckel, K. G.
Kappen, P.
Zhang, H.
Lombi, E.
TI Speciation and Lability of Ag-, AgCl-, and Ag2S-Nanoparticles in Soil
Determined by X-ray Absorption Spectroscopy and Diffusive Gradients in
Thin Films
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SILVER SULFIDE NANOPARTICLES; WASTE-WATER; SEWAGE-SLUDGE; ENVIRONMENTAL
TRANSFORMATIONS; ENGINEERED NANOMATERIALS; IN-SITU; TOXICITY; FATE;
BEHAVIOR; LIGANDS
AB Long-term speciation and lability of silver (Ag-), silver chloride (AgCl-), and silver sulfide nanoparticles (Ag2S-NPs) in soil were studied by X-ray absorption spectroscopy (XAS), and newly developed nano Diffusive Gradients in Thin Films (DGT) devices. These nano-DGT devices were designed specifically to avoid confounding effects when measuring element lability in the presence of nanoparticles. The aging profile and stabilities of the three nanoparticles and AgNO3 (ionic Ag) in soil were examined at three different soil pH values over a period of up to 7 months. Transformation of ionic Ag, Ag-NP and AgCl-NPs were dependent on pH. AgCl formation and persistence was observed under acidic conditions, whereas sulfur-bound forms of Ag dominated in neutral to alkaline soils. Ag2S-NPs were found to be very stable under all conditions tested and remained sulfur bound after 7 months of incubation. Ag lability was characteristically low in soils containing Ag2S-NPs. Other forms of Ag were linked to higher DGT-determined lability, and this varied as a function of aging and related speciation changes as determined by XAS. These results clearly indicate that Ag2S-NPs, which are the most environmentally relevant form of Ag that enter soils, are chemically stable and have profoundly low Ag lability over extended periods. This may minimize the long-term risks of Ag toxicity in the soil environment.
C1 [Sekine, R.; Brunetti, G.; Donner, E.; Lombi, E.] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes Campus, SA 5095, Australia.
[Khaksar, M.; Vasilev, K.] Univ S Australia, Mawson Inst, Mawson Lakes Campus, SA 5095, Australia.
[Jaemting, A. K.] Natl Measurement Inst, Lindfield, NSW 2070, Australia.
[Scheckel, K. G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
[Kappen, P.] Australian Synchrotron, Clayton, Vic 3168, Australia.
[Zhang, H.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England.
RP Sekine, R (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg 10, Mawson Lakes Campus, SA 5095, Australia.
EM Ryo.Sekine@unisa.edu.au
RI Sekine, Ryo/F-3721-2013; ID, MRCAT/G-7586-2011; Zhang, Hao/E-5375-2010;
Donner, Erica/A-4809-2012; Lombi, Enzo/F-3860-2013
OI Scheckel, Kirk/0000-0001-9326-9241; Sekine, Ryo/0000-0001-9980-0603;
Donner, Erica/0000-0001-6465-2233; Lombi, Enzo/0000-0003-3384-0375
FU Australian Research Council Future Fellowship [FT100100337, FT100100292,
FT130101003]; Australian Research Council [DP120101115]; DOE Office of
Science by Argonne National Laboratory [DE-AC02-06CH11357]; EPA;
Australian Synchrotron
FX E.L., K.V., and E.D. are recipients of Australian Research Council
Future Fellowship FT100100337, FT100100292, and FT130101003,
respectively. The funding support from the Australian Research Council
Discovery Project DP120101115 is gratefully acknowledged. We thank Dr
Hamid M. Pouran for his assistance with the Nano-DGT devices. The
Australian Synchrotron is acknowledged for the beamtime on the X-ray
Absorption Spectroscopy Beamline (AS132 XAS6663a and XAS6663b),
associated travel funding, and Dr. Bernt Johannessen and Dr. Chris
Glover for assistance during the beamtime. The software tool "Sakura"
was developed at the Australian Synchrotron in partnership with the
National eResearch Collaborative Tools and Resources (NeCTAR) project.
MRCAT operations are supported by the Department of Energy and the MRCAT
member-institutions. This research used resources of the Advanced Photon
Source, a U.S. Department of Energy (DOE) Office of Science User
Facility operated for the DOE Office of Science by Argonne National
Laboratory under Contract No. DE-AC02-06CH11357. Although EPA
contributed to this article, the research presented was not performed by
or funded by EPA and was not subject to EPA's quality system
requirements. Consequently, the views, interpretations, and conclusions
expressed in this article are solely those of the authors and do not
necessarily reflect or represent EPA's views or policies.
NR 50
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Z9 17
U1 15
U2 101
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 20
PY 2015
VL 49
IS 2
BP 897
EP 905
DI 10.1021/es504229h
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AZ6LY
UT WOS:000348332400026
PM 25436975
ER
PT J
AU Washington, JW
Jenkins, TM
Rankin, K
Naile, JE
AF Washington, John W.
Jenkins, Thomas M.
Rankin, Keegan
Naile, Jonathan E.
TI Decades-Scale Degradation of Commercial, Side-Chain, Fluorotelomer-Based
Polymers in Soils and Water
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SLUDGE-APPLIED SOILS; DEGRADABILITY; PERSISTENCE; ALCOHOLS; ALABAMA;
DECATUR; USA
AB Fluorotelomer-based polymers (FTPs) are the primary product of the fluorotelomer industry. Here we report on a 376-day study of the degradability of two commercial acrylate-linked FTPs in four saturated soils and in water. Using an exhaustive serial extraction, we report GC/MS and LC/MS/MS results for 50 species including fluorotelomer alcohols and acids, and perfluorocarboxylates. Modeling of seven sampling rounds, each consisting of >= 5 replicate microcosm treatments, for one commercial FTP in one soil yielded half-life estimates of 65-112 years and, when the other commercial FTP and soils were evaluated, the estimated half-lives ranged from 33 to 112 years. Experimental controls, consisting of commercial FTP in water, degraded roughly at the same rate as in soil. A follow-up experiment, with commercial FTP in pH 10 water, degraded roughly 10-fold faster than the circum-neutral control suggesting that commercial FTPs can undergo OH-mediated hydrolysis. 8:2Fluorotelomer alcohol generated from FTP degradation in soil was more stable than without FTP present suggesting a clathrate guest-host association with the FTP. To our knowledge, these are the only degradability-test results for commercial FTPs that have been generated using exhaustive extraction procedures. They unambiguously show that commercial FTPs, the primary product of the fluorotelomer industry, are a source of fluorotelomer and perfluorinated compounds to the environment.
C1 [Washington, John W.; Naile, Jonathan E.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Jenkins, Thomas M.] Senior Environm Employment Program, Athens, GA 30605 USA.
[Rankin, Keegan] Univ Toronto, Dept Chem, Toronto, ON 141119, Canada.
RP Washington, JW (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
EM Washington.john@epa.gov
FU USEPA Office of Research Development; Office of Pollution Prevention
Toxics
FX This research was funded by the USEPA Office of Research & Development
and Office of Pollution Prevention & Toxics. We thank Greg Fritz, Jack
Jones, Laurence Libelo, David Lynch and Eric Weber, all of the EPA, and
the editor and manuscript reviewers for insightful comments. We thank
Chrys Wesdemiotis (University of Akron) for the opportunity to analyze
samples by MALDI-TOF. Views expressed in this paper do not necessarily
represent the views or policies of the USEPA. Mention of trade names or
products does not convey EPA approval, endorsement or recommendation.
The authors declare no competing financial interest.
NR 28
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U1 6
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 20
PY 2015
VL 49
IS 2
BP 915
EP 923
DI 10.1021/es504347u
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AZ6LY
UT WOS:000348332400028
PM 25426868
ER
PT J
AU Watkins, AM
Wood, CR
Lin, MT
Abbott, BD
AF Watkins, Andrew M.
Wood, Carmen R.
Lin, Mimi T.
Abbott, Barbara D.
TI The effects of perfluorinated chemicals on adipocyte differentiation in
vitro
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE PFOA; PFNA; PFHxS; PFOS; PPAR; Adipocyte
ID ACTIVATED-RECEPTOR-ALPHA; PERFLUOROOCTANOIC ACID; PERFLUOROALKYL ACIDS;
PPAR-ALPHA; DEVELOPMENTAL TOXICITY; NUCLEAR RECEPTORS; FATTY-ACIDS;
MOUSE; ADIPOGENESIS; ENDOCRINE
AB The 3T3-L1 preadipocyte culture system has been used to examine numerous compounds that influence adipocyte differentiation or function. The perfluoroalkyl acids (PFAAs), used as surfactants in a variety of industrial applications, are of concern as environmental contaminants that are detected worldwide in human serum and animal tissues. This study was designed to evaluate the potential for PFAAs to affect adipocyte differentiation and lipid accumulation using mouse 3T3-L1 cells. Cells were treated with perfluorooctanoic acid (PFOA) (5-1001.1,M), perfluorononanoic acid (PFNA) (5-10012M), perfluorooctane sulfonate (PFOS) (50-300 iM), perfluorohexane sulfonate (PFHxS) (40-250 IiM), the peroxisome proliferator activated receptor (PPAR) PPARa agonist Wyeth-14,643 (WY-14,643), and the PPARy agonist rosiglitazone. The PPARy agonist was included as a positive control as this pathway is critical to adipocyte differentiation. The PPARa agonist was included as the PFAA compounds are known activators of this pathway. Cells were assessed morphometrically and biochemically for number, size, and lipid content. RNA was extracted for qPCR analysis of 13 genes selected for their importance in adipocyte differentiation and lipid metabolism. There was a significant concentration-related increase in cell number and decreased cell size after exposure to PFOA, PFHxS, PFOS, and PFNA. All four PFAA treatments produced a concentrationrelated decrease in the calculated average area occupied by lipid per cell. However, total triglyceride levels per well increased with a concentration-related trend for all compounds, likely due to the increased cell number. Expression of mRNA for the selected genes was affected by all exposures and the specific impacts depended on the particular compound and concentration. Acox1 and Gapdh were upregulated by all six compounds. The strongest overall effect was a nearly 10-fold induction of Scdl by PFHxS. The sulfonated PFAAs-produced numerous, strong-changes in gene expression similar to the effects after treatment with the PPARy agonist rosiglitazone. By comparison, the effects on gene expression were muted for the carboxylated PFAAs and for the PPARa agonist WY-14,643. In summary, all perfluorinated compounds increased cell number, decreased cell size, increased total triglyceride, and altered expression of genes associated with adipocyte differentiation and lipid metabolism. Published by Elsevier Ireland Ltd.
C1 [Watkins, Andrew M.; Wood, Carmen R.; Lin, Mimi T.; Abbott, Barbara D.] US EPA, Dev Toxicol Branch, Natl Hlth & Environm Effects Res Lab, Toxic Assessment Div,Off Res & Dev, Res Triangle Pk, NC 27709 USA.
RP Watkins, AM (reprint author), US EPA, NHEERL TAD DTB, MD-B105-04, Res Triangle Pk, NC 27709 USA.
EM watkins.andrew@epa.gov
NR 41
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U1 9
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2015
VL 400
IS C
BP 90
EP 101
DI 10.1016/j.mce.2014.10.020
PG 12
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA CA3SJ
UT WOS:000348826100010
PM 25448844
ER
PT J
AU Moser, VC
Stewart, N
Freeborn, DL
Crooks, J
MacMillan, DK
Hedge, JM
Wood, CE
McMahen, RL
Strynar, MJ
Herr, DW
AF Moser, Virginia C.
Stewart, Nicholas
Freeborn, Danielle L.
Crooks, James
MacMillan, Denise K.
Hedge, Joan M.
Wood, Charles E.
McMahen, Rebecca L.
Strynar, Mark J.
Herr, David W.
TI Assessment of serum biomarkers in rats after exposure to pesticides of
different chemical classes
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Biomarkers; Cytokines; Metabolomics; Hormones; Pesticides
ID DISCRIMINANT-ANALYSIS; SELECTIVE TOXICITY; VARIABLE SELECTION; FIPRONIL
SULFONE; INSECTICIDES; RECEPTORS; CYTOKINES; SYSTEM; BIOSYNTHESIS;
METABOLISM
AB There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and targeted metabolite profiles after exposure to pesticides (permethrin, deltamethrin, imidacloprid, carbaryl, triadimefon, fipronil) with different neurotoxic actions. Adult male Long Evans rats were evaluated after single exposure to vehicle or one of two doses of each pesticide at the time of peak effect. The doses were selected to produce similar magnitude of behavioral effects across chemicals. Serum or plasma was analyzed using commercial cytokine/protein panels and targeted metabolomics. Additional studies of fipronil used lower doses (lacking behavioral effects), singly or for 14 days, and included additional markers of exposure and biological activity. Biomarker profiles varied in the number of altered analytes and patterns of change across pesticide classes, and discriminant analysis could separate treatment groups from control. Low doses of fipronil produced greater effects when given for 14 days compared to a single dose. Changes in thyroid hormones and relative amounts of fipronil and its sulfone metabolite also differed between the dosing regimens. Most cytokine changes reflected alterations in inflammatory responses, hormone levels, and products of phospholipid, fatty acid, and amino acid metabolism. These findings demonstrate distinct blood-based analyte profiles across pesticide classes, dose levels, and exposure duration. These results show promise for detailed analyses of these biomarkers and their linkages to biological pathways. Published by Elsevier Inc.
C1 [Moser, Virginia C.; Stewart, Nicholas; Freeborn, Danielle L.; Herr, David W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxidty Assessment Div,Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA.
[Crooks, James; MacMillan, Denise K.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Analyt Chem Res Core,Res Cores Unit, Res Triangle Pk, NC 27711 USA.
[Hedge, Joan M.; Wood, Charles E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[McMahen, Rebecca L.; Strynar, Mark J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA.
RP Moser, VC (reprint author), US EPA, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM Moser.ginger@epa.gov
FU Office of Research and Development, U.S. Environmental Protection Agency
FX The authors gratefully acknowledge the assistance of Ms Judy Richards
for liver enzyme assays, and Drs Steve Edwards and Brian Chorley for
their review of this manuscript. This research was funded by the
intramural research program of the Office of Research and Development,
U.S. Environmental Protection Agency.
NR 53
TC 9
Z9 11
U1 4
U2 34
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2015
VL 282
IS 2
BP 161
EP 174
DI 10.1016/j.taap.2014.11.016
PG 14
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CA8UC
UT WOS:000349195400005
PM 25497286
ER
PT J
AU Freeborn, DL
McDaniel, KL
Moser, VC
Herr, DW
AF Freeborn, Danielle L.
McDaniel, Katherine L.
Moser, Virginia C.
Herr, David W.
TI Use of electroencephalography (EEG) to assess CNS changes produced by
pesticides with different modes of action: Effects of permethrin,
deltamethrin, fipronil, imidacloprid, carbaryl, and triadimefon
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE EEG; Pesticides; Rats
ID ACETYLCHOLINESTERASE INHIBITOR CHLORPYRIFOS; SENSORY EVOKED-POTENTIALS;
POWER SPECTRA; PYRETHROID INSECTICIDES; TRIAZOLE FUNGICIDE;
PSYCHOPHYSIOLOGICAL RESEARCH; INDUCED CHOREOATHETOSIS; CHOLINESTERASE
ACTIVITY; ALZHEIMERS-DISEASE; SELECTIVE TOXICITY
AB The electroencephalogram (EEG) is an apical measure, capable of detecting changes in brain neuronal activity produced by internal or external stimuli. We assessed whether pesticides with different modes of action produced different changes in the EEG of adult male Long-Evans rats. The EEG was recorded using two montages (visual cortex referenced to the cerebellum and to the frontal cortex) in unrestrained rats at the time of peak behavioral effects. Pesticides included: permethrin and deltamethrin (Type land Type II pyrethroids; 2 h), fipronil (single and repeated doses; phenylpyrazole; 6 h), imidacloprid (neonicotinoid; 2 h), carbaryl (carbamate; 0.5 h), and triadimefon (triazole; 1 h), using dosages that produced approximately an ED30 or an ED50-ED80 change in motor activity. Permethrin (43, 100 mg/kg) increased amplitudes or areas (delta, alpha, or gamma bands) in the EEG. Deltamethrin (2.5, 5.5 mg/kg) reduced the amplitudes or areas of the delta, theta, alpha, beta, and gamma bands, but the changes were not dose-related. A single treatment with fipronil (25, 50 mg/kg, but not 5, 10 mg/kg) decreased gamma band area. Additional changes in the delta, theta, and gamma bands were observed when fipronil (5, 10 mg/kg) was administered for 14 days. Imidacloprid (50, 100 mg/kg) did not alter the EEG. Carbaryl (10, 50 mg/kg) decreased theta area, and decreased delta and increased beta frequency. Triadimefon (75, 150 mg/kg) produced minimal changes in the EEG. The results show that the EEG is affected differently by approximately equipotent doses of pesticides with different modes of action. Published by Elsevier Inc.
C1 [Freeborn, Danielle L.; McDaniel, Katherine L.; Moser, Virginia C.; Herr, David W.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Neurotoxicol Branch,Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
RP Herr, DW (reprint author), US EPA, NHEERL TAD NB, 109 TW Alexander Dr,MD 8105-05, Res Triangle Pk, NC 27711 USA.
EM Freebom.danielle@epa.gov; McDaniel.kathy@epa.gov; Moser.ginger@epa.gov;
Herr.david@epa.gov
FU United States Environmental Protection Agency
FX We thank Drs. Tim Shafer and William Boyes for their helpful comments on
an earlier version of this manuscript. Appreciation is also expressed to
Mr. Charles Hamm for the computer assistance and Dr. Laura Degn with the
technical assistance with experimental procedures. All work was
internally funded by the United States Environmental Protection Agency.
NR 95
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Z9 2
U1 6
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2015
VL 282
IS 2
BP 184
EP 194
DI 10.1016/j.taap.2014.11.011
PG 11
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CA8UC
UT WOS:000349195400007
PM 25481984
ER
PT J
AU Vanderhoof, MK
Williams, CA
AF Vanderhoof, Melanie K.
Williams, Christopher A.
TI Persistence of MODIS evapotranspiration impacts from mountain pine
beetle outbreaks in lodgepole pine forests, south-central Rocky
Mountains
SO AGRICULTURAL AND FOREST METEOROLOGY
LA English
DT Article
DE Evapotranspiration; Water cycle; Bark beetles; Mountain pine beetles;
Disturbance; MODIS
ID SUB-ALPINE FOREST; ENERGY-EXCHANGE; WATER YIELD; STAND AGE; LEAF-AREA;
VEGETATION; ALGORITHM; COLORADO; CARBON; SCALE
AB The current extent and high severity (percent tree mortality) of mountain pine beetle outbreaks across western North America has been attributed to regional climate change, specifically warmer summer and winter temperatures and drier summers. This study paired multiple mountain pine beetle outbreak location datasets, both current and historical, with Moderate Resolution Imaging Spectroradiometer (MODIS) and Global Modeling and Assimilation Office (GMAO) Modern Era Retrospective-Analysis for Research and Applications (MERRA) products in order to quantify the full seasonal evapotranspiration impact of outbreak events for decades after outbreak (0 to 60 years). Following mountain pine beetle outbreaks in lodgepole pine (Pinus contorta) stands in the Colorado Rockies we observed an 18.7 +/- 1.4% (p < 0.01) reduction in the rate of summer evapotranspiration at 14 to 20 years since outbreak. We also observed a 21.6 +/- 2.2% (p < 0.01) increase in the rate of summer evapotranspiration, relative to non-attacked stands, in intermediate-aged stands 30 to 40 years since outbreak. Changes to growing season evapotranspiration correlated positively with changes in stand density, stand leaf area index (LAI) and the fraction of absorbed photosynthetically active radiation (fPAR), while high incoming solar radiation during the summer months acted to amplify changes to evapotranspiration even given relatively minor changes to summer WAR and LAI due to the rapid regeneration of understory vegetation. Lodgepole pine mortality from mountain pine beetle outbreaks showed lasting effects on stand-scale evapotranspiration which could have important implications for regional water resources. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Vanderhoof, Melanie K.; Williams, Christopher A.] Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA.
RP Vanderhoof, MK (reprint author), US EPA, ORISE, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave,NW 8623-P, Washington, DC 20460 USA.
EM vanderhoof.melanie@epa.gov
FU NASA Headquarters under the NASA Earth and Space Science Fellowship
Program [12-Earth12R-59, 13-Earth13R-8]; Science of Terra and Aqua
program [NASA ROSES09, NNX11AG53G]; National Science Foundation
[1262691]
FX This work was supported by NASA Headquarters under the NASA Earth and
Space Science Fellowship Program (Grant no. 12-Earth12R-59 and
13-Earth13R-8). Additional financial support was received from the NASA
ROSES09 Science of Terra and Aqua program (Grant no. NNX11AG53G) as well
as the National Science Foundation (Grant no. 1262691). We thank Rocky
Mountain National Park for their field support and Marcus Pasay for his
assistance with field work. We also thank Dominik Kulakowski and Dan
Jarvis for providing the dendroecological plot data, Brian Howell and
Justin Backsen of the USFS Region 2, for their assistance with the
historical ADS surveys, and the anonymous reviewers for the valuable
comments.
NR 79
TC 4
Z9 4
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1923
EI 1873-2240
J9 AGR FOREST METEOROL
JI Agric. For. Meteorol.
PD JAN 15
PY 2015
VL 200
BP 78
EP 91
DI 10.1016/j.agrformet.2014.09.015
PG 14
WC Agronomy; Forestry; Meteorology & Atmospheric Sciences
SC Agriculture; Forestry; Meteorology & Atmospheric Sciences
GA AY4ZB
UT WOS:000347582300008
ER
PT J
AU Simon, H
Reff, A
Wells, B
Xing, J
Frank, N
AF Simon, Heather
Reff, Adam
Wells, Benjamin
Xing, Jia
Frank, Neil
TI Ozone Trends Across the United States over a Period of Decreasing NOx
and VOC Emissions
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID GROUND-LEVEL OZONE; AIR
AB In this work, we evaluate ambient ozone trends at urban, suburban, and rural monitoring sites across the United States over a period of decreasing NOx and VOC emissions (1998-2013). We find that decreasing ozone trends generally occur in the summer, in less urbanized areas, and at the upper end of the ozone distribution. Conversely, increasing ozone trends generally occur in the winter, in more urbanized areas, and at the lower end of the ozone distribution. The 95(th) percentile ozone concentrations decreased at urban, suburban, and rural monitors by 1-2 ppb/yr in the summer and 0.5-1 ppb/yr in the winter. In the summer, there are both increasing and decreasing trends in fifth percentile ozone concentrations of less than 0.5 ppb/yr at urban and suburban monitors, while fifth percentile ozone concentrations at rural monitors decreased by up to 1 ppb/yr. In the winter, fifth percentile ozone concentrations generally increased by 0.1-1 ppb/yr. These results demonstrate the large scale success of U.S. control strategies targeted at decreasing peak ozone concentrations. In addition, they indicate that as anthropogenic NOx emissions have decreased, the ozone distribution has been compressed, leading to less spatial and temporal variability.
C1 [Simon, Heather; Reff, Adam; Wells, Benjamin; Frank, Neil] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Xing, Jia] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Simon, H (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM Simon.Heather@epa.gov
RI xing, jia/O-1784-2014; simon, heather/E-4392-2011
OI simon, heather/0000-0001-7254-3360
FU U.S. Department of Energy [DE-SC000378]; U.S. EPA [25 RW-89-9233260 1]
FX The authors would like to thank the following people from U.S. EPA for
their helpful feedback on this manuscript: James Hemby, Tyler Fox, Liz
Naess, Norm Possiel, Pat Dolwick, Bryan Hubbell, Scott Mathias, Mike
Koerber, Chet Wayland, Jan Cortelyou-Lee, and Chuen-Meei Gan. Although
this work has been reviewed and approved for publication by the U.S.
Environmental Protection Agency (EPA), it does not reflect the views and
policies of the agency. J.X. held a National Research Council Associate
award at U.S. EPA supported in part by an interagency agreement between
the U.S. Department of Energy project (IA no. DE-SC000378) and the U.S.
EPA (IA no. 25 RW-89-9233260 1).
NR 33
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Z9 33
U1 10
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 6
PY 2015
VL 49
IS 1
BP 186
EP 195
DI 10.1021/es504514z
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AY5BW
UT WOS:000347589300021
PM 25517137
ER
PT J
AU Mazur, CS
Marchitti, SA
Zastre, J
AF Mazur, Christopher S.
Marchitti, Satori A.
Zastre, Jason
TI P-glycoprotein inhibition by the agricultural pesticide propiconazole
and its hydroxylated metabolites: Implications for pesticide-drug
interactions
SO TOXICOLOGY LETTERS
LA English
DT Article
DE P-gp; MDR1; Conazoles; Propiconazole; Chemosensitization; ABC
transporters
ID NONSTEROIDAL AROMATASE INHIBITORS; ORAL BIOAVAILABILITY; IN-VITRO;
CLINICAL IMPORTANCE; CACO-2 CELLS; TRANSPORTERS; ERYTHROMYCIN; EFFLUX;
KETOCONAZOLE; ANTIFUNGALS
AB The human efflux transporter P-glycoprotein (P-gp, MDR1) functions as an important cellular defense system against a variety of xenobiotics; however, little information exists on whether environmental chemicals interact with P-gp. Conazoles provide a unique challenge to exposure assessment because of their use as both pesticides and drugs. Propiconazole is an agricultural pesticide undergoing evaluation by the U. S. Environmental Protection Agency's Endocrine Disruptor Screening Program. In this study, the P-gp interaction of propiconazole and its hydroxylated metabolites were evaluated using MDR1expressing membrane vesicles and NIH-3T3/MDR1 cells. Membrane vesicle assays demonstrated propiconazole (IC50,122.9 mu M) and its metabolites (IC(50)s, 350.8 mu M, 366.4 mu M, and 456.3 mu M) inhibited P-gp efflux of a probe substrate, with propiconazole demonstrating the strongest interaction. P-gp mediated transport of propiconazole in MDR1-expressed vesicles was not detected indicating propiconazole interacts with P-gp as an inhibitor rather than a substrate. In NIH-3T3/MDR1 cells, propiconazole (1 and 10 mu M) led to decreased cellular resistance (chemosensitization) to paclitaxel, a chemotherapeutic drug and known MDR1 substrate. Collectively, these results have pharmacokinetic and risk assessment implications as P-gp interaction may influence pesticide toxicity and the potential for pesticide-drug interactions. Published by Elsevier Ireland Ltd.
C1 [Mazur, Christopher S.; Marchitti, Satori A.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Zastre, Jason] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA.
RP Mazur, CS (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM mazur.chris@epa.gov; marchitti.satori@epa.gov; jzastre@uga.edu
NR 36
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Z9 3
U1 3
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD JAN 5
PY 2015
VL 232
IS 1
BP 37
EP 45
DI 10.1016/j.toxlet.2014.09.020
PG 9
WC Toxicology
SC Toxicology
GA AW3GT
UT WOS:000346175100005
PM 25268938
ER
PT J
AU Vance, L
Eason, T
Cabezas, H
AF Vance, Leisha
Eason, Tarsha
Cabezas, Heriberto
TI An information theory-based approach to assessing the sustainability and
stability of an island system
SO INTERNATIONAL JOURNAL OF SUSTAINABLE DEVELOPMENT AND WORLD ECOLOGY
LA English
DT Article
DE Fisher information; Puerto Rico; regional system; sustainability;
dynamic order; indicator
ID SAN-LUIS BASIN; REGIONAL SUSTAINABILITY; FISHER INFORMATION; REGIME
SHIFTS; PUERTO-RICO; CRITICAL TRANSITIONS; ECOLOGICAL-SYSTEMS; COLORADO;
COMMUNICATION; FRAMEWORK
AB It is well documented that a sustainable system is based on environmental stewardship, economic viability, and social equity. What is often overlooked is the need for continuity such that desirable system behavior is maintained with mechanisms in place that facilitate the ability of core system functions to endure or adapt (in the face of perturbations), and ensure that future generations are able to meet their needs. Assessing regional systems poses unique challenges in that they are interlinked with larger- and smaller-scale dynamics that may dramatically affect trends in key system variables. From 1970-2009, Puerto Rico experienced a 140% increase in urban population which may have amplified impacts related to resource demands, waste production, and natural habitats. Because such changes can have strong implications for sustainability, the dynamics of Puerto Rico provide a great opportunity to explore methods for assessing the sustainability of a complex geographic region. In this work, we employ Fisher information, an information theory-based approach, to evaluate changes in system dynamics and examine the effect of regionalization impacts on trends in variables characterizing social, environmental, and economic aspects of the system. Results indicate dramatic change from 1981-1999, after which the system dynamics remained steady until 2005. While there was no indication that a regime shift occurred, system trends corresponded with variations in non-yield economic variables. To determine whether Fisher information provides warning signals of critical change, consecutive declines in the index were explored and demonstrated as a possible leading indicator of impending regime shifts.
C1 [Vance, Leisha; Eason, Tarsha; Cabezas, Heriberto] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Cabezas, H (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Cabezas.Heriberto@epa.gov
FU U.S. EPA
FX U.S. EPA.
NR 53
TC 2
Z9 2
U1 1
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1350-4509
EI 1745-2627
J9 INT J SUST DEV WORLD
JI Int. J. Sustain. Dev. World Ecol.
PD JAN 2
PY 2015
VL 22
IS 1
BP 64
EP 75
DI 10.1080/13504509.2014.978832
PG 12
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Ecology
SC Science & Technology - Other Topics; Environmental Sciences & Ecology
GA CA8GM
UT WOS:000349155800007
ER
PT J
AU Kariisa, M
Foraker, R
Pennell, M
Buckley, T
Diaz, P
Criner, GJ
Wilkins, JR
AF Kariisa, Mbabazi
Foraker, Randi
Pennell, Michael
Buckley, Timothy
Diaz, Philip
Criner, Gerard J.
Wilkins, J. R., III
TI Short- and Long-Term Effects of Ambient Ozone and Fine Particulate
Matter on the Respiratory Health of Chronic Obstructive Pulmonary
Disease Subjects
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE spirometry; COPD; air pollution; lung function
ID EMPHYSEMA TREATMENT TRIAL; VOLUME REDUCTION SURGERY; AIR-POLLUTION;
NATIONAL EMPHYSEMA; EXPOSURE; QUESTIONNAIRE; PATHOGENESIS
AB To date, no study has evaluated the short- and long-term effects air pollution exposure on emphysematous subjects who have undergone lung volume reduction surgery (LVRS). Data from the National Emphysema Treatment Trial study (1998-2003) included 1,218 subjects, aged 39 to 84. Daily values of ambient fine particulate matter (aerodynamic diameter < 2.5 mu m; PM2.5) and ozone were obtained. Mixed-effects models tested the association between short- and long-term pollutant concentrations and changes in pulmonary function. Cumulative air pollution exposure was strongly associated with worsened respiratory function and symptoms. Mean PM2.5 was associated with poorer lung function. Lagged exposures were poorly associated with respiratory health outcomes. There were detrimental respiratory and pulmonary effects observed in response to even low levels of ambient air pollutants among study participants. These results are indicative that exposures even below those of air quality standards may still pose significant risks to severe chronic obstructive pulmonary disease (COPD) subjects.
C1 [Kariisa, Mbabazi; Foraker, Randi; Wilkins, J. R., III] Ohio State Univ, Coll Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA.
[Pennell, Michael] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA.
[Buckley, Timothy] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Diaz, Philip] Ohio State Univ, Wexner Med Ctr, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
[Criner, Gerard J.] Temple Univ, Sch Med, Ctr Inflammat Translat & Clin Lung Res, Dept Med,Sect Pulm & Crit Care Med, Philadelphia, PA 19122 USA.
RP Kariisa, M (reprint author), Ohio Dept Hlth, Violence & Injury Prevent Program, Bur Hlth Ohio, 246 North High St, Columbus, OH 43215 USA.
EM mbabazi.kariisa@odh.ohio.gov
NR 23
TC 5
Z9 5
U1 4
U2 43
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1933-8244
EI 2154-4700
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PD JAN 2
PY 2015
VL 70
IS 1
BP 56
EP 62
DI 10.1080/19338244.2014.932753
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AW3OP
UT WOS:000346196600008
PM 25136856
ER
PT J
AU Bostian, M
Sinha, A
Whittaker, G
Barnhart, B
AF Bostian, Moriah
Sinha, Ankur
Whittaker, Gerald
Barnhart, Bradley
GP IEEE
TI Incorporating Data Envelopment Analysis Solution Methods into Bilevel
Multi-Objective Optimization
SO 2015 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC)
SE IEEE Congress on Evolutionary Computation
LA English
DT Proceedings Paper
CT IEEE Congress on Evolutionary Computation (CEC)
CY MAY 25-28, 2015
CL Sendai, JAPAN
SP IEEE
DE Bilevel multi-objective optimization; Data envelopment analysis; Bilevel
evolutionary algorithm; Nitrogen pollution
ID EVOLUTIONARY ALGORITHMS; EFFICIENCY ANALYSIS; GENETIC ALGORITHM;
DECISION-MAKING; MANAGEMENT; SERVICES; MODELS; DEA
AB This study illustrates the use of Data Envelopment Analysis (DEA) solution methods in bilevel optimization problems. Here, we show that DEA and bilevel optimization can also be used together as part of an integrated solution framework. We work with a policy-oriented problem in which the regulator's multi-objective optimization problem at the upper level is constrained by the profit-maximizing decisions of individual firms at the lower level. Each firm's response to the policy is a prori unknown to the regulator, and depends on the underlying production technology. Rather than assuming a common production relationship across firms, DEA allows us to model each firm's response to the policy without imposing a functional form on the production technology. We use DEA to estimate the technology facing each producer, based on observed practices of other producers. Doing so endogenizes the cost of responding to prospective policies at the lower level, providing a more realistic solution set at the upper level. Our application addresses the design of a policy to reduce fertilizer runoff from agriculture, an important problem in environmental economics. We employ a multi-objective bilevel evolutionary algorithm to solve for the approximate optimal frontier.
C1 [Bostian, Moriah] Lewis & Clark Coll, Dept Econ, Portland, OR 97219 USA.
[Sinha, Ankur] Indian Inst Management, Prod & Quantitat Methods, Ahmadabad 380015, Gujarat, India.
[Whittaker, Gerald] USDA ARS, Corvallis, OR 97331 USA.
[Barnhart, Bradley] US EPA, Corvallis, OR 97331 USA.
RP Bostian, M (reprint author), Lewis & Clark Coll, Dept Econ, Portland, OR 97219 USA.
EM mbbostian@lclark.edu; asinha@iimahd.ernet.in; whittakg@onid.orst.edu;
bradleybarnhart@gmail.com
NR 38
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-7492-4
J9 IEEE C EVOL COMPUTAT
PY 2015
BP 1667
EP 1674
PG 8
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BF1YE
UT WOS:000380444801092
ER
PT B
AU Jerrett, M
Reid, CE
McKone, TE
Koutrakis, P
AF Jerrett, Michael
Reid, Colleen E.
McKone, Thomas E.
Koutrakis, Petros
BE Kanaroglou, P
Delmelle, E
Paez, A
TI Participatory and Ubiquitous Sensing for Exposure Assessment in Spatial
Epidemiology
SO SPATIAL ANALYSIS IN HEALTH GEOGRAPHY
SE Geographies of Health
LA English
DT Article; Book Chapter
ID FINE PARTICULATE MATTER; AIR-POLLUTION EXPOSURE; LONG-TERM EXPOSURE;
AEROSOL OPTICAL DEPTH; LAND-USE REGRESSION; PHYSICAL-ACTIVITY;
INFORMATION-SYSTEM; COMMUNITY DESIGN; PARTICLE MONITOR; SATELLITE
C1 [Jerrett, Michael] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA.
[Jerrett, Michael; McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Reid, Colleen E.] Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci, Berkeley, CA 94720 USA.
[Reid, Colleen E.] US EPA, Global Change Res Program, Washington, DC 20460 USA.
[McKone, Thomas E.] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
[McKone, Thomas E.] US EPA, Sci Advisory Board, Washington, DC 20460 USA.
[McKone, Thomas E.] World Hlth Org, Geneva, Switzerland.
[McKone, Thomas E.] Soc Risk Anal, Mclean, VA USA.
[McKone, Thomas E.] Int Soc Exposure Sci, Herndon, VA USA.
[Koutrakis, Petros] EPA Harvard Univ, Clean Air Res Ctr, Cambridge, MA USA.
[Koutrakis, Petros] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA.
RP Jerrett, M (reprint author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA.
NR 91
TC 0
Z9 0
U1 0
U2 0
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-47-241620-9; 978-1-47-241619-3
J9 GEOGR HEALTH
PY 2015
BP 219
EP 239
PG 21
WC Geography; Public, Environmental & Occupational Health
SC Geography; Public, Environmental & Occupational Health
GA BG0RI
UT WOS:000386481100013
ER
PT B
AU Andrew, JT
AF Andrew, John T.
BA Lassiter, A
BF Lassiter, A
TI Adapting California's Water Sector to a Changing Climate
SO SUSTAINABLE WATER: CHALLENGES AND SOLUTIONS FROM CALIFORNIA
LA English
DT Article; Book Chapter
C1 [Andrew, John T.] Calif Dept Water Resources, Climate Change Act, Sacramento, CA 95814 USA.
[Andrew, John T.] Stege Sanit Dist, El Cerrito, CA USA.
[Andrew, John T.] CALFED Bay Delta Program, Sacramento, CA USA.
[Andrew, John T.] Calif Dept Hlth Serv, Sacramento, CA 95814 USA.
[Andrew, John T.] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
[Andrew, John T.] US Environm Protect Agcy, Washington, DC USA.
RP Andrew, JT (reprint author), Calif Dept Water Resources, Climate Change Act, Sacramento, CA 95814 USA.
NR 26
TC 0
Z9 0
U1 0
U2 0
PU UNIV CALIFORNIA PRESS
PI OAKLAND
PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA
BN 978-0-520-28535-4; 978-0-520-96087-9; 978-0-520-28536-1
PY 2015
BP 10
EP 31
PG 22
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Studies; Water
Resources
SC Science & Technology - Other Topics; Environmental Sciences & Ecology;
Water Resources
GA BG0JU
UT WOS:000386291200002
ER
PT S
AU Steeger, T
Baris, R
Moriarty, T
Hart, C
Hou, W
AF Steeger, Thomas
Baris, Reuben
Moriarty, Thomas
Hart, Connie
Hou, Wayne
BE Oomen, PA
Pistorius, J
TI Assessing risks of pesticides to bees: putting the science into context
to inform regulatory decision making
SO HAZARDS OF PESTICIDES TO BEES: 12TH INTERNATIONAL SYMPOSIUM OF THE
ICP-PR BEE PROTECTION GROUP
SE Julius-Kuhn-Archiv
LA English
DT Proceedings Paper
CT 12th International Symposium of the ICP-PR Bee Protection Group -
Hazards of Pesticides to Bees
CY SEP 15-17, 2014
CL Ghent Univ, Fac Bioscience Engn, Ghent, BELGIUM
SP Int Commiss Plant Protect Relat
HO Ghent Univ, Fac Bioscience Engn
ID DECLINES; EUROPE
C1 [Steeger, Thomas; Baris, Reuben; Moriarty, Thomas] US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
[Hart, Connie; Hou, Wayne] Hlth Canada, Pest Management Regulatory Agcy, Environm Assessment Directorate, Ottawa, ON, Canada.
RP Steeger, T (reprint author), US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
NR 20
TC 0
Z9 0
U1 2
U2 2
PU JULIUS KUHN-INST
PI BERLIN
PA BUNDESFORSCHUNGSINSTITUT FUR KULTURPFLANZEN, KONIGN-LUISE-STRABE 19,
BERLIN, D-14195, GERMANY
SN 1868-9892
BN 978-3-95547-022-7
J9 JULIUS-KUHN-ARCH
JI Julius-Kuhn-Arch.
PY 2015
VL 450
BP 8
EP 16
PG 9
WC Entomology; Toxicology
SC Entomology; Toxicology
GA BF4YW
UT WOS:000381782400001
ER
PT S
AU Bakker, F
Christl, H
Coulson, M
Dinter, A
Giffard, H
Hanewald, N
Lewis, G
Miles, M
Pistorius, J
van Praagh, J
Randall, M
Vergnet, C
Hart, C
Sandrock, C
Steeger, T
AF Bakker, Frank
Christl, Heino
Coulson, Mike
Dinter, Axel
Giffard, Herve
Hanewald, Nicole
Lewis, Gavin
Miles, Mark
Pistorius, Jens
van Praagh, Job
Randall, Marit
Vergnet, Christine
Hart, Connie
Sandrock, Christoph
Steeger, Thomas
BE Oomen, PA
Pistorius, J
TI Semi-field and field testing on the honey bee working group
SO HAZARDS OF PESTICIDES TO BEES: 12TH INTERNATIONAL SYMPOSIUM OF THE
ICP-PR BEE PROTECTION GROUP
SE Julius-Kuhn-Archiv
LA English
DT Proceedings Paper
CT 12th International Symposium of the ICP-PR Bee Protection Group -
Hazards of Pesticides to Bees
CY SEP 15-17, 2014
CL Ghent Univ, Fac Bioscience Engn, Ghent, BELGIUM
SP Int Commiss Plant Protect Relat
HO Ghent Univ, Fac Bioscience Engn
C1 [Bakker, Frank] Eurofins, Amsterdam, Netherlands.
[Christl, Heino] Tier, Leichlingen, Germany.
[Coulson, Mike] Syngenta, Basel, Switzerland.
[Dinter, Axel] DuPont Co Inc, Wilmington, DE USA.
[Giffard, Herve] Testapi, Gennes, France.
[Hanewald, Nicole] BASF, Ludwigshafen, Germany.
[Lewis, Gavin] JSC, Harrogate, N Yorkshire, England.
[Miles, Mark] BCS, New Orleans, LA USA.
[Pistorius, Jens] JKI, Quedlinburg, Germany.
[van Praagh, Job] ICPPR, Guelph, ON, Canada.
[Randall, Marit] Norwegian FSA, Oslo, Norway.
[Vergnet, Christine] ANSES, Maisons Alfort, France.
[Hart, Connie] Hlth Canada, Ottawa, ON, Canada.
[Sandrock, Christoph] IES, Witterswil, Switzerland.
[Steeger, Thomas] US EPA, Washington, DC 20460 USA.
RP Bakker, F (reprint author), Eurofins, Amsterdam, Netherlands.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU JULIUS KUHN-INST
PI BERLIN
PA BUNDESFORSCHUNGSINSTITUT FUR KULTURPFLANZEN, KONIGN-LUISE-STRABE 19,
BERLIN, D-14195, GERMANY
SN 1868-9892
BN 978-3-95547-022-7
J9 JULIUS-KUHN-ARCH
JI Julius-Kuhn-Arch.
PY 2015
VL 450
BP 152
EP 153
PG 2
WC Entomology; Toxicology
SC Entomology; Toxicology
GA BF4YW
UT WOS:000381782400025
ER
PT S
AU Humayun, M
Divan, R
Stan, L
Rosenmann, D
Gosztola, D
Gundel, L
Solomon, PA
Paprotny, I
AF Humayun, Md
Divan, R.
Stan, L.
Rosenmann, D.
Gosztola, D.
Gundel, L.
Solomon, P. A.
Paprotny, I.
GP IEEE
TI Functionalized Multi-Walled Carbon Nanotube based Sensors for
Distributed Methane Leak Detection
SO 2015 IEEE SENSORS
SE IEEE Sensors
LA English
DT Proceedings Paper
CT 2015 IEEE SENSORS
CY NOV 01-04, 2015
CL Busan, SOUTH KOREA
SP IEEE, Sensors Council, Korean Sensors Soc
AB This paper presents a highly sensitive, energy efficient and low-cost distributed methane (CH4) sensor system (DMSS) for continuous monitoring, detection and localization of CH4 leaks in natural gas infrastructure such as transmission and distribution pipelines, wells, and production pads. The CH4 sensing element, a key component of the DMSS, consists of a metal oxide functionalized multi-walled carbon nanotube (MWCNT) mesh which, in comparison to existing literature, shows stronger relative resistance change while interacting with lower ppm concentreation of CH4. For the DMSS a Gaussian plume triangulation algorithm has been developed, which, given a geometric model of the surrounding environment, can precisely detect and localize a CH4 leak as well as estimate its mass flow rate.
C1 [Humayun, Md; Paprotny, I.] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
[Divan, R.; Stan, L.; Rosenmann, D.; Gosztola, D.] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA.
[Gundel, L.] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Solomon, P. A.] US EPA, Las Vegas, NV 89199 USA.
RP Humayun, M (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
EM paprotny@uic.edu
NR 7
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1930-0395
BN 978-1-4799-8203-5
J9 IEEE SENSOR
PY 2015
BP 177
EP 180
PG 4
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA BF1WO
UT WOS:000380440800046
ER
PT S
AU Mahdavipour, O
Mueller-Sim, T
Fahimi, D
Croshere, S
Pillatsch, P
Merukh, J
Baruffa, VZ
Sabino, J
Tran, K
Alanis, G
Solomon, P
Wright, P
White, RM
Gundel, L
Paprotny, I
AF Mahdavipour, Omid
Mueller-Sim, Timothy
Fahimi, Dorsa
Croshere, Skot
Pillatsch, Pit
Merukh, Jusuf
Baruffa, Valentino Zegna
Sabino, John
Tran, Koji
Alanis, Giovanni
Solomon, Paul
Wright, Paul
White, Richard M.
Gundel, Lara
Paprotny, Igor
GP IEEE
TI Wireless Sensors for Automated Control of Total Incombustible Content
(TIC) of Dust Deposited in Underground Coal Mines
SO 2015 IEEE SENSORS
SE IEEE Sensors
LA English
DT Proceedings Paper
CT 2015 IEEE SENSORS
CY NOV 01-04, 2015
CL Busan, SOUTH KOREA
SP IEEE, Sensors Council, Korean Sensors Soc
DE Float Dust; Wireless Sensor Networks; Total Incombustible Content
AB This paper presents ongoing research towards a low-cost/low-power wirelessly enabled distributed sensing system that can be placed throughout underground coal mines to potentially measure the total incombustible content (TIC) of the deposited dust. Underground coal mining operations produce finely divided coal dust, called float dust, which deposits throughout the mine. This combustible material can be feedstock for coal dust explosions. In the U.S., Mine Safety and Health Administration (MSHA) standard 23789 dictates that a TIC of 80% or above has to be maintained in coal mine return airways. However, current best practices for collection TIC measurements involve manual sampling and laboratory procedures. In this work, we describe work towards developing a new wireless sensor network (WSN) consisting of low-cost/low-power sensor modules that use a variety of optical and microfabricated sensors to continuously monitor the TIC of the accumulated dust. The information is then transmitted off-board through a reliable ad-hoc wireless network. Called Sensors for Automated Control of Coal Dust (SACCD), this system can potentially, for example, be used to automate the control of rock-dusting equipment to maintain TIC at acceptable levels.
C1 [Mahdavipour, Omid; Mueller-Sim, Timothy; Fahimi, Dorsa; Baruffa, Valentino Zegna; Sabino, John; Tran, Koji; Alanis, Giovanni; Paprotny, Igor] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
[Croshere, Skot; Pillatsch, Pit; Merukh, Jusuf; Wright, Paul; White, Richard M.] Univ Calif, Berkeley, CA USA.
[Solomon, Paul] US EPA, Las Vegas, NV 89193 USA.
[Gundel, Lara] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
RP Mahdavipour, O (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
EM paprotny@uic.edu
NR 6
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1930-0395
BN 978-1-4799-8203-5
J9 IEEE SENSOR
PY 2015
BP 703
EP 706
PG 4
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA BF1WO
UT WOS:000380440800187
ER
PT J
AU Bolt, MD
AF Bolt, M. D.
BE Yang, C
Clarke, K
Yuan, M
Yu, M
Li, M
Guan, W
Sun, M
Huang, B
TI Visualizing Water Quality Sampling-Events in Florida
SO ISPRS International Workshop on Spatiotemporal Computing
LA English
DT Proceedings Paper
CT ISPRS International Workshop on Spatiotemporal Computing
CY JUL 13-15, 2015
CL Fairfax, VA
DE Water Quality; Visualization; Florida; R; GIS; Spatiotemporal;
Communication
AB Water quality sampling in Florida is acknowledged to be spatially and temporally variable. The rotational monitoring program that was created to capture data within the state's thousands of miles of coastline and streams, and millions of acres of lakes, reservoirs, and ponds may be partly responsible for inducing the variability as an artifact. Florida's new dissolved-oxygen-standard methodology will require more data to calculate a percent saturation. This additional data requirement's impact can be seen when the new methodology is applied retrospectively to the historical collection. To understand how, where, and when the methodological change could alter the environmental quality narrative of state waters requires addressing induced bias from prior sampling events and behaviors. Here stream and coastal water quality data is explored through several modalities to maximize understanding and communication of the spatiotemporal relationships. Previous methodology and expected-retrospective calculations outside the regulatory framework are found to be significantly different, but dependent on the spatiotemporal perspective. Data visualization is leveraged to demonstrate these differences, their potential impacts on environmental narratives, and to direct further review and analysis.
C1 [Bolt, M. D.] US EPA, Oak Ridge Inst Sci & Educ, Sam Nunn Atlanta Fed Ctr, 61 Forsyth St SW, Atlanta, GA 30303 USA.
RP Bolt, MD (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Sam Nunn Atlanta Fed Ctr, 61 Forsyth St SW, Atlanta, GA 30303 USA.
EM bolt.matthew@epa.gov
NR 8
TC 0
Z9 0
U1 0
U2 0
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLE 1E, GOTTINGEN, 37081, GERMANY
PY 2015
BP 73
EP 78
DI 10.5194/isprsannals-II-4-W2-73-2015
PG 6
WC Computer Science, Interdisciplinary Applications; Geography, Physical;
Remote Sensing; Imaging Science & Photographic Technology
SC Computer Science; Physical Geography; Remote Sensing; Imaging Science &
Photographic Technology
GA BF3IZ
UT WOS:000380547600031
ER
PT J
AU Arunachalam, S
Brantley, H
Barzyk, TM
Hagler, G
Isakov, V
Kimbrough, ES
Naess, B
Rice, N
Snyder, MG
Talgo, K
Venkatram, A
AF Arunachalam, Saravanan
Brantley, Halley
Barzyk, Timothy M.
Hagler, Gayle
Isakov, Vlad
Kimbrough, Evelyn S.
Naess, Brian
Rice, Nathan
Snyder, Michelle G.
Talgo, Kevin
Venkatram, Akula
TI Assessment of port-related air quality impacts: geographic analysis of
population
SO INTERNATIONAL JOURNAL OF ENVIRONMENT AND POLLUTION
LA English
DT Article
DE port; emissions; air quality; dispersion; GIS; cargo; freight; trucks;
near source; near port; population exposure
ID HEALTH
AB Increased global trade has led to greater transportation by rail, road and ships to move cargo. Based upon multiple near-road and near-source monitoring studies, the busy roadways and large emission sources at ports may impact local air quality within several hundred metres of the ports. Health effects have been associated with near-road exposures and proximity to large emission sources, so characterising emission sources is important for understanding potential health effects. To address this need, we have developed a new community-scale tool called C-PORT to model emissions related to all port-area activities and predict concentrations of multiple criteria and hazardous air pollutants at fine spatial scales in the near-source environment. We present a geographical information system analysis of areas surrounding five US ports (Ports of New York and New Jersey, Virginia, Savannah, Miami, and Houston) to determine potential sources of concern related to freight transport and demographics of the near-source population that could be affected.
C1 [Arunachalam, Saravanan; Naess, Brian; Snyder, Michelle G.; Talgo, Kevin] Univ North Carolina Chapel Hill, Inst Environm, Campus Box 1105 27599-1105,100 Europa Dr, Chapel Hill, NC 27517 USA.
[Brantley, Halley; Kimbrough, Evelyn S.] US EPA, Air Pollut Prevent & Characterizat Div, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Barzyk, Timothy M.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Hagler, Gayle] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Isakov, Vlad] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Rice, Nathan] Univ North Carolina Chapel Hill, Informat Technol Serv Res Comp, Chapel Hill, NC 27599 USA.
[Venkatram, Akula] Univ Calif Riverside, Bourns Coll Engn, Riverside, CA 92521 USA.
RP Arunachalam, S (reprint author), Univ North Carolina Chapel Hill, Inst Environm, Campus Box 1105 27599-1105,100 Europa Dr, Chapel Hill, NC 27517 USA.
EM sarav@email.unc.edu; brantley.halley@epa.gov; Barzyk.Timothy@epa.gov;
Hagler.Gayle@epa.gov; Isakov.Vlad@epa.gov; Kimbrough.Sue@epa.gov;
naess@unc.edu; Nathan_rice@unc.edu; mgs3584@email.unc.edu;
talgo@email.unc.edu; venky@engr.ucr.edu
OI Kimbrough, Evelyn Sue/0000-0002-7246-0255
NR 27
TC 0
Z9 0
U1 1
U2 4
PU INDERSCIENCE ENTERPRISES LTD
PI GENEVA
PA WORLD TRADE CENTER BLDG, 29 ROUTE DE PRE-BOIS, CASE POSTALE 856, CH-1215
GENEVA, SWITZERLAND
SN 0957-4352
EI 1741-5101
J9 INT J ENVIRON POLLUT
JI Int. J. Environ. Pollut.
PY 2015
VL 58
IS 4
SI SI
BP 231
EP 250
DI 10.1504/IJEP.2015.077455
PN 3
PG 20
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DQ5AL
UT WOS:000379216700002
ER
PT B
AU Shadbegian, RJ
Wolverton, A
AF Shadbegian, Ronald J.
Wolverton, Ann
BE Konisky, DM
TI Evaluating Environmental Justice: Analytic Lessons from the Academic
Literature and in Practice
SO FAILED PROMISES: EVALUATING THE FEDERAL GOVERNMENT'S RESPONSE TO
ENVIRONMENTAL JUSTICE
SE American and Comparative Environmental Policy
LA English
DT Article; Book Chapter
ID SOUTHERN CALIFORNIA; TOXIC RELEASES; AIR TOXICS; EQUITY; RISK;
DEMOGRAPHICS; INEQUITIES; ENFORCEMENT; PERFORMANCE; DISPARITIES
C1 [Shadbegian, Ronald J.] US EPA, NCEE, Washington, DC 20460 USA.
RP Shadbegian, RJ (reprint author), US EPA, NCEE, Washington, DC 20460 USA.
EM Shadbegian.ron@epa.gov; Wolverton.ann@epa.gov
NR 59
TC 1
Z9 1
U1 1
U2 1
PU MIT PRESS
PI CAMBRIDGE
PA FIVE CAMBRIDGE CENTER, CAMBRIDGE, MA 02142 USA
BN 978-0-262-52735-4; 978-0-262-02883-7
J9 AM COMP ENVIRON POLI
PY 2015
BP 117
EP 142
D2 10.7551/mitpress/9780262028837.001.0001
PG 26
WC Environmental Studies; Political Science; Social Sciences,
Interdisciplinary
SC Environmental Sciences & Ecology; Government & Law; Social Sciences -
Other Topics
GA BE8GM
UT WOS:000376451800007
ER
PT J
AU Ghio, A
Soukup, J
Dailey, L
Kesic, MJ
Cohen, MD
AF Ghio, A.
Soukup, J.
Dailey, L.
Kesic, M. J.
Cohen, M. D.
TI Iron Diminishes The In Vitro Biological Effect Of Vanadium
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Ghio, A.; Soukup, J.; Dailey, L.] US EPA, Chapel Hill, NC USA.
[Kesic, M. J.] Univ N Carolina, Chapel Hill, NC USA.
[Cohen, M. D.] NYU, Tuxedo Pk, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A3214
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582803489
ER
PT J
AU Kim, CS
Kehrl, H
Hazucha, M
Rappold, A
Devlin, RB
Diaz-Sanchez, D
AF Kim, C. S.
Kehrl, H.
Hazucha, M.
Rappold, A.
Devlin, R. B.
Diaz-Sanchez, D.
TI Variability Of Pulmonary Function Response To 6.6 Hour Exposure To Low
Concentration Ozone During Moderate Exercise
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Kim, C. S.; Kehrl, H.; Rappold, A.; Devlin, R. B.; Diaz-Sanchez, D.] US EPA, Res Triangle Pk, NC USA.
[Hazucha, M.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A5242
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582807062
ER
PT J
AU Soukup, JM
Dailey, L
Kesic, MJ
Tong, H
Ghio, A
AF Soukup, J. M.
Dailey, L.
Kesic, M. J.
Tong, H.
Ghio, A.
TI Wood Smoke Particles Sequester Mitochondrial Iron To Impact A Biological
Effect
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Soukup, J. M.; Dailey, L.; Tong, H.; Ghio, A.] US EPA, Chapel Hill, NC USA.
[Kesic, M. J.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A4034
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582805093
ER
PT J
AU Yu, Y
Hotten, D
Birukova, A
Volker, E
Ghio, AJ
Noble, PW
Kraft, M
Hollingsworth, JW
Gunn, MD
Tighe, RM
AF Yu, Y.
Hotten, D.
Birukova, A.
Volker, E.
Ghio, A. J.
Noble, P. W.
Kraft, M.
Hollingsworth, J. W.
Gunn, M. D.
Tighe, R. M.
TI Flow Cytometry Of Human Bronchoalveolar Lavage Fluid And Lung Tissue
Identifies Interstitial Macrophages
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Yu, Y.; Hotten, D.; Birukova, A.; Volker, E.; Kraft, M.; Gunn, M. D.; Tighe, R. M.] Duke Univ, Med Ctr, Durham, NC USA.
[Ghio, A. J.] US EPA, Chapel Hill, NC USA.
[Noble, P. W.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Hollingsworth, J. W.] Ohio State Univ, Columbus, OH 43210 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A1301
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582800300
ER
PT S
AU Briskin, JS
Yohannes, L
AF Briskin, J. S.
Yohannes, L.
BE Drogos, DL
TI Overview of US EPA's Study of the Potential Impacts of Hydraulic
Fracturing for Oil and Gas on Drinking Water Resources
SO HYDRAULIC FRACTURING: ENVIRONMENTAL ISSUES
SE ACS Symposium Series
LA English
DT Article; Book Chapter
ID ENVIRONMENTAL-SAMPLES
C1 [Briskin, J. S.; Yohannes, L.] US EPA, Off Sci Policy, Off Res & Dev, 1200 Penn Ave NW,Mail Code 8104R, Washington, DC 20460 USA.
RP Briskin, JS (reprint author), US EPA, Off Sci Policy, Off Res & Dev, 1200 Penn Ave NW,Mail Code 8104R, Washington, DC 20460 USA.
EM Briskin.jeanne@epa.gov
NR 19
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3122-1
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1216
BP 197
EP 203
D2 10.1021/bk-2015-1216
PG 7
WC Engineering, Petroleum; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA BE5KI
UT WOS:000372944300009
ER
PT B
AU Xi, W
Ottinger, RL
Robinson, NA
Butzel, AK
Wieder, ME
Parker, JL
Rucinski, TL
Valova, RR
Wang, PP
AF Xi, Wang
Ottinger, Richard L.
Robinson, Nicholas A.
Butzel, Albert K.
Wieder, Marla E.
Parker, John Louis
Rucinski, Taryn L.
Valova, Radina R.
Wang Pianpian
BE Martin, P
Kennedy, A
TI Assessing environmental governance of the Hudson River Valley:
application of an IPPEP model
SO IMPLEMENTING ENVIRONMENTAL LAW
SE IUCN Academy of Environmental Law Series
LA English
DT Article; Book Chapter
C1 [Xi, Wang] Shanghai Jiao Tong Univ, Nat Resources Law Inst, Shanghai 200030, Peoples R China.
[Ottinger, Richard L.] IUCN World Commiss Environm Law, Energy & Climate Comm, London, England.
[Robinson, Nicholas A.] Pace Univ, Environm, New York, NY USA.
[Robinson, Nicholas A.] Pace Univ, Environm Law, New York, NY USA.
[Robinson, Nicholas A.] IUCN, New York, NY USA.
[Butzel, Albert K.] Albert K Butzel Law Off, New York, NY USA.
[Wieder, Marla E.] US EPA, Washington, DC USA.
[Parker, John Louis] NY Dept Environm Conservat, Washington, DC USA.
[Rucinski, Taryn L.] Pace Univ, Sch Law, Law, New York, NY USA.
RP Xi, W (reprint author), Shanghai Jiao Tong Univ, Nat Resources Law Inst, Shanghai 200030, Peoples R China.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU EDWARD ELGAR PUBLISHING LTD
PI CHELTENHAM
PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND
BN 978-1-78347-931-3; 978-1-78347-929-0
J9 IUCN ACAD ENVIR LAW
PY 2015
BP 50
EP 68
D2 10.4337/9781783479313
PG 19
WC Environmental Studies; Law
SC Environmental Sciences & Ecology; Government & Law
GA BE5DZ
UT WOS:000372628400003
ER
PT J
AU Ridley, CE
Mallory-Smith, C
AF Ridley, Caroline E.
Mallory-Smith, Carol
BE Quinn, LD
Matlaga, DP
Barney, JN
TI Gene Flow and Invasiveness in Bioenergy Systems
SO BIOENERGY AND BIOLOGICAL INVASIONS: ECOLOGICAL, AGRONOMIC, AND POLICY
PERSPECTIVES ON MINIMIZING RISK
SE CABI Invasives Series
LA English
DT Article; Book Chapter
ID JATROPHA-CURCAS L.; CANOLA BRASSICA-NAPUS; CALIFORNIA WILD RADISH;
PANICUM-VIRGATUM L.; GM OILSEED RAPE; CAMELINA-SATIVA; WIND-POLLINATION;
TRANSGENIC CROPS; RISK-ASSESSMENT; WESTERN CANADA
AB Gene flow between crops and their wild or weedy relatives can result in the establishment of hybrid populations outside of cultivation. Here, we examine the potential for gene flow between several emerging bioenergy feedstocks and their compatible relatives, and the factors that affect the magnitude and frequency of gene exchange. We also explore the potential that gene flow could lead to the escape of transgenes or invasion by resulting populations. A limited amount of information suggests that the potential for gene flow and invasion are low for jatropha (Jatropha curcas L.) and relatively greater for switchgrass (Panicum virgatum L.) where these crops are currently being cultivated. Camelina (Camelina sativa (L.) Crantz.) likely falls somewhere in between these two species. Canola (Brassica napus L. and Brassica rapa L.), a widely-grown crop already being used as a source of bioenergy, is a well-studied system in which weedy populations with crop ancestry have been found and transgenes have been detected outside of cultivation. From this case study, we suggest that both a Best Management Plan should be developed to limit gene flow between emerging bioenergy feedstocks and wild or weedy relatives, and a Mitigation Plan should be in place to address unintended release of transgenes and appearance of potentially invasive populations.
C1 [Ridley, Caroline E.] US EPA, 1200 Penn Ave NW,William Jefferson Clinton Bldg, Washington, DC 20460 USA.
[Mallory-Smith, Carol] Oregon State Univ, Dept Crop & Soil Sci, Corvallis, OR 97331 USA.
RP Ridley, CE (reprint author), US EPA, 1200 Penn Ave NW,William Jefferson Clinton Bldg, Washington, DC 20460 USA.
EM ridley.caroline@epa.gov; carol.mallory-smith@oregonstate.edu
NR 74
TC 0
Z9 0
U1 2
U2 9
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-78064-330-4
J9 CABI INVASIVE SER
PY 2015
VL 5
BP 52
EP 66
D2 10.1079/9781780643304.0000
PG 15
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA BE6SD
UT WOS:000374698700004
ER
PT J
AU Tirado, MC
Amadeo, A
Chena, K
Mascarenas, A
AF Tirado, M. C.
Amadeo, A.
Chena, K.
Mascarenas, A.
TI Climate smart nutrition: Co-benefits of nutrition-sensitive climate
mitigation and adaptation
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Meeting Abstract
C1 [Tirado, M. C.; Amadeo, A.; Chena, K.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
[Tirado, M. C.] Int Union Nutr Sci Task Force Climate & Nutr, Washington, DC USA.
[Mascarenas, A.] US EPA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2015
VL 67
SU 1
BP 19
EP 20
PG 2
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DK5VM
UT WOS:000374988800030
ER
PT S
AU Hollingsworth, JW
Nadadur, SS
AF Hollingsworth, John W.
Nadadur, Srikanth S.
BE Nadadur, SS
Hollingsworth, JW
TI Air Pollution and Health Effects Preface
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Editorial Material; Book Chapter
ID AMERICAN-HEART-ASSOCIATION; CARDIOVASCULAR-DISEASE; STATEMENT
C1 [Hollingsworth, John W.] Ohio State Univ, Dept Internal Med, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
[Nadadur, Srikanth S.] Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA.
RP Hollingsworth, JW (reprint author), Ohio State Univ, Dept Internal Med, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
NR 5
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP V
EP VII
D2 10.1007/978-1-4471-6669-6
PG 3
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200001
ER
PT S
AU Mudipalli, A
AF Mudipalli, Anuradha
BE Nadadur, SS
Hollingsworth, JW
TI Airborne Carcinogens: Mechanisms of Cancer
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
ID POLYCYCLIC AROMATIC-HYDROCARBONS; ENVIRONMENTAL TOBACCO-SMOKE;
UNSCHEDULED DNA-SYNTHESIS; BENZENE-EXPOSED WORKERS; EXPERIMENTAL
MULTIPOTENTIAL CARCINOGEN; ALCOHOL-DEHYDROGENASE 3; STRAND BREAK REPAIR;
PROTEIN CROSS-LINKS; LUNG-CANCER; OCCUPATIONAL-EXPOSURE
C1 [Mudipalli, Anuradha] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Mudipalli, A (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Mudipalli.anu@epa.gov
NR 216
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 151
EP 184
DI 10.1007/978-1-4471-6669-6_6
D2 10.1007/978-1-4471-6669-6
PG 34
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200007
ER
PT S
AU Sacks, JD
Fann, N
Owens, EO
Costa, DL
AF Sacks, Jason D.
Fann, Neal
Owens, Elizabeth Oesterling
Costa, Daniel L.
BE Nadadur, SS
Hollingsworth, JW
TI Using Science to Shape Policy
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
ID PARTICULATE AIR-POLLUTION; UNITED-STATES; CHEMICAL-COMPOSITION; LIFE
EXPECTANCY; GLOBAL BURDEN; HEALTH BURDEN; MATTER; MORTALITY; OZONE;
ASSOCIATION
C1 [Sacks, Jason D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
[Owens, Elizabeth Oesterling] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Cincinnati, OH 45268 USA.
[Fann, Neal] US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, Res Triangle Pk, NC 27711 USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Sacks, JD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM sacks.jason@epa.gov; fann.neal@epa.gov; owens.beth@epa.gov;
costa.dan@epa.gov
NR 47
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 403
EP 436
DI 10.1007/978-1-4471-6669-6_15
D2 10.1007/978-1-4471-6669-6
PG 34
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200016
ER
PT S
AU Dewan, N
Majestic, BJ
Ketterer, ME
Miller-Schulze, JP
Shafer, MM
Schauer, JJ
Solomon, PA
Artamonova, M
Chen, BB
Imashev, SA
Carmichael, GR
AF Dewan, Nitika
Majestic, Brian J.
Ketterer, Michael E.
Miller-Schulze, Justin P.
Shafer, Martin M.
Schauer, James J.
Solomon, Paul A.
Artamonova, Maria
Chen, Boris B.
Imashev, Sanjar A.
Carmichael, Gregory R.
BE Evans, KR
RobertsKirchhoff, ES
Benvenuto, MA
Lanigan, KC
RihanaAbdallah, A
TI Tracing Dust Sources Using Stable Lead and Strontium Isotopes in Central
Asia
SO TRACE MATERIALS IN AIR, SOIL, AND WATER
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Trace Materials in Air, Soil, and Water at the 249th
American-Chemical-Society National Meeting
CY MAR 22-26, 2015
CL Denver, CO
SP Amer Chem Soc, Div Environm Chem Inc
ID AIRBORNE PARTICULATE MATTER; DEPOSITION; AEROSOLS; TRACERS; PB;
PARTICLES; EVOLUTION; POLLUTION; METALS; FRANCE
AB From 1960 to 2014, the Aral Sea's surface area has receded about 90% in size from 68,000 km(2) to 8,444 km(2). Consequently, newly exposed sediments are resuspended by the wind and are now a source of atmospheric particulate matter in Central Asia, which may have an impact on human health and climate. In this study, strontium (Sr) and lead (Pb) stable isotopic ratios, along with other elemental compositions, are used to determine if the Aral Sea sediments are an important source of air pollution to Central Asia. Ambient particulate matter with aerodynamic diameter < 10 mu m (PM10) samples were collected every other day and included dust and non-dust events at the Bishkek and LIDAR (in Teploklyuchenka) in Kyrgyzstan. Soil samples also were collected in the vicinity of the air sampling sites, resuspended, and sized as PM10 for chemical analysis. The average Sr-87/Sr-86 ratio for the Aral Sea sediments was 0.70992 (range, 0.70951 - 0.71064), which is less radiogenic than the surface soils in Kyrgyzstan showing an average ratio of 0.71579 (range, 0.71448 - 0.71739). In contrast, the airborne PM10 collected in Kyrgyzstan had an average 87Sr/86Sr ratio of 0.71177 (range, 0.70946 - 0.71335), which is between the two ratios, indicating a possible mixture of sources. However, no differences in Sr ratios were observed between dust and non-dust events, which implies that the impact of Aral Sea sediments on the sampling sites is minimal. The element enrichment factors and stable Pb isotope ratios are employed to further understand the source of PM10 to. Airborne PM10 are characterized by enrichments in elements like As, Cd, Cu, Mo, Pb, and Zn at both sampling sites. The mean (K/Pb) ratio for aerosols is similar to 45 and for soils is similar to 800, which suggest that the aerosols contain a significant fraction of anthropogenic source of airborne Pb in Kyrgyzstan. Pb-208/Pb-206 ratios are higher for aerosols compared to the Kyrgyzstan soils and Aral Sea sediments also suggesting that Pb is most likely present due to anthropogenic sources.
C1 [Dewan, Nitika; Majestic, Brian J.] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA.
[Ketterer, Michael E.] Metropolitan State Univ Denver, Dept Chem, Denver, CO 80204 USA.
[Miller-Schulze, Justin P.] Calif State Univ Sacramento, Dept Chem, Sacramento, CA 95819 USA.
[Shafer, Martin M.; Schauer, James J.] Wisconsin State Lab Hyg, Madison, WI 53718 USA.
[Shafer, Martin M.; Schauer, James J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA.
[Solomon, Paul A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA.
[Artamonova, Maria] Russian Acad Sci, Inst Atmospher Phys, Moscow 109017, Russia.
[Chen, Boris B.; Imashev, Sanjar A.] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan.
[Carmichael, Gregory R.] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA.
RP Majestic, BJ (reprint author), Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA.
EM brian.majestic@du.edu
RI Imashev, Sanjar/I-7667-2016
OI Imashev, Sanjar/0000-0003-3293-3764
NR 36
TC 0
Z9 0
U1 3
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3110-8
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1210
BP 79
EP 98
PG 20
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BE3SA
UT WOS:000371198800004
ER
PT S
AU Wheeler, WJ
AF Wheeler, William J.
BE Johnston, RJ
Rolfe, J
Rosenberger, RS
Brouwer, R
TI Benefit Transfer for Water Quality Regulatory Rulemaking in the United
States
SO BENEFIT TRANSFER OF ENVIRONMENTAL AND RESOURCE VALUES: A GUIDE FOR
RESEARCHERS AND PRACTITIONERS
SE Economics of Non-Market Goods and Resources
LA English
DT Article; Book Chapter
DE Water quality valuation; Regulatory impact analysis; Benefit transfer
ID WILLINGNESS-TO-PAY; IMPROVEMENTS; METAANALYSIS; VALUATION
AB This chapter describes the use of benefit transfer in Regulatory Impact Analyses for surface water quality regulations at the U.S. Environmental Protection Agency (EPA). It begins by explaining the regulatory framework at the EPA and existing guidance on the use of benefit transfer. It then describes how benefit transfer has been applied in practice for water quality RIAs and how that practice has changed over time: from the use of unit value transfers to more sophisticated function and meta-analytic transfers. The chapter concludes with observations about the practical application of benefit transfer methods at the EPA and how this practice diverges from the academic literature.
C1 [Wheeler, William J.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Wheeler, WJ (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
EM Wheeler.william@epa.gov
NR 59
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1571-487X
BN 978-94-017-9930-0; 978-94-017-9929-4
J9 ECON NON-MARK GOOD
PY 2015
VL 14
BP 101
EP 115
DI 10.1007/978-94-017-9930-0_6
D2 10.1007/978-94-017-9930-0
PG 15
WC Economics; Environmental Studies
SC Business & Economics; Environmental Sciences & Ecology
GA BE1PO
UT WOS:000368358100007
ER
PT S
AU Luo, PP
Apip
He, B
Takara, K
Duan, WL
Hu, MC
Nover, D
AF Luo, Pingping
Apip
He, Bin
Takara, Kaoru
Duan, Weili
Hu, Maochuan
Nover, Daniel
BE Li, J
Yang, X
TI Modelling Shallow Landslide Risk Using GIS and a Distributed
Hydro-geotechnical Model
SO MONITORING AND MODELING OF GLOBAL CHANGES: A GEOMATICS PERSPECTIVE
SE Springer Remote Sensing Photogrammetry
LA English
DT Article; Book Chapter
DE GIS; Distributed hydro-geotechnical model; Shallow landslide risk;
Probability; Kyushu Island
ID PHYSICALLY-BASED MODEL; HAZARD; SCALE
AB GIS and distributed hydrological models are important tools for shallow landslide prediction, particularly as such disasters are exacerbated by global change driven changes in precipitation regimes. The main objective of this chapter is to outline a detailed methodology for shallow landslide risk assessment using GIS and a hydrological model. We have developed a method to assess shallow landslide risk using GIS tools and a distributed hydrological model and further used this method to analyze the probability of shallow landslides in a case study. The physically based distributed landslide model was developed by integrating a grid-based distributed kinematic wave rainfall-runoff model combined with an infinite slope stability module. Application of the model to assess shallow landslide risk using rainfall data for Kyushu Island shows that the model can successfully predict the effect of rainfall distribution and intensity on the driving variables that trigger shallow landslides. The modeling system has broad applicability for shallow landslide prediction and warning.
C1 [Luo, Pingping] United Nations Univ, Inst Adv Study Sustainabil UNU IAS, Shibuya Ku, Tokyo, Japan.
[Luo, Pingping; Takara, Kaoru] Kyoto Univ, DPRI, Uji, Kyoto, Japan.
[Apip] Indonesian Inst Sci LIPI, Limnol Res Ctr, Cibinong, Indonesia.
[He, Bin; Duan, Weili] Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing, Jiangsu, Peoples R China.
[Hu, Maochuan] Kyoto Univ, Grad Sch Engn, Dept Civil & Earth Resources Engn, Nishikyo Ku, Kyoto 6158530, Japan.
[Nover, Daniel] US EPA, Global Change Res Program, Washington, DC 20460 USA.
RP Luo, PP (reprint author), United Nations Univ, Inst Adv Study Sustainabil UNU IAS, Shibuya Ku, Tokyo, Japan.
EM luoping198121@gmail.com; apip@limnologi.lipi.go.id; hebin@niglas.ac.cn;
takara.kaoru.7v@kyoto-u.ac.jp; wlduan@nislas.ac.cn; hu-maochuan@163.com;
dmnover@gmail.com
NR 23
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 2198-0721
BN 978-94-017-9813-6; 978-94-017-9812-9
J9 SPRING REMOTE SENS P
PY 2015
BP 221
EP 240
DI 10.1007/978-94-017-9813-6_11
D2 10.1007/978-94-017-9813-6
PG 20
WC Environmental Sciences; Remote Sensing
SC Environmental Sciences & Ecology; Remote Sensing
GA BE0OH
UT WOS:000366486500012
ER
PT B
AU Cascio, WE
AF Cascio, Wayne E.
BE Wang, H
Patterson, C
Pratico, D
Jain, MK
Yang, X
Sibinga, NES
Feinberg, MW
TI LIFE STYLE
SO ATHEROSCLEROSIS: RISKS, MECHANISMS, AND THERAPIES
LA English
DT Article; Book Chapter
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; MATTER
AIR-POLLUTION; HEINZ NIXDORF RECALL; CARDIOVASCULAR-DISEASE;
ALCOHOL-CONSUMPTION; SUBCLINICAL ATHEROSCLEROSIS; ENDOTHELIAL FUNCTION;
PHYSICAL-ACTIVITY; TOBACCO-SMOKE
C1 [Cascio, Wayne E.] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
[Cascio, Wayne E.] Univ N Carolina, Dept Med, Div Cardiol, Chapel Hill, NC USA.
RP Cascio, WE (reprint author), US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
NR 67
TC 0
Z9 0
U1 1
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-82853-3; 978-1-118-28591-6
PY 2015
BP 93
EP 103
D2 10.1002/9781118828533
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA BE2JJ
UT WOS:000369411200010
ER
PT S
AU Perkins, E
Garcia-Reyero, N
Edwards, S
Wittwehr, C
Villeneuve, D
Lyons, D
Ankley, G
AF Perkins, Edward
Garcia-Reyero, Natalia
Edwards, Stephen
Wittwehr, Clemens
Villeneuve, Daniel
Lyons, David
Ankley, Gerald
BE Hoeng, J
Peitsch, MC
TI The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity
Testing in the Twenty-First Century
SO COMPUTATIONAL SYSTEMS TOXICOLOGY
SE Methods in Pharmacology and Toxicology
LA English
DT Article; Book Chapter
DE Predictive toxicology; Ecotoxicology; Key events; Computational biology;
Network science; Risk assessment
ID MINNOW PIMEPHALES-PROMELAS; HUMAN RELEVANCE FRAMEWORK; FOLLICULAR CELL
TUMORS; EARLY FISH DEVELOPMENT; RISK-ASSESSMENT; FATHEAD MINNOW; CANCER
MODE; NETWORK INFERENCE; THYROID-HORMONE; IPCS FRAMEWORK
AB The need to rapidly characterize the risk of large numbers of chemicals has moved the traditional toxicological paradigm from animal testing to a pathway-based approach using in vitro assay systems and modeling where possible. Adverse Outcome Pathways (AOPs) provide a conceptual framework that can be used to link in vitro assay results to whole animal effects in a pathway context. AOPs are defined and examples are provided to demonstrate key characteristics of AOPs. To support development and application of AOPs, a knowledge base has been developed containing a Wiki site designed to permit documentation of AOPs in a crowd-sourced manner. Both empirical and computational methods are demonstrated to play a significant role in AOP development. The combination of computational approaches, including different modeling efforts, together with apical end points within the pathway-based framework will allow for a better understanding of the linkage of events from a molecular initiating event to a potential adverse outcome, therefore defi ning key events, AOPs, and even networks of AOPS. While these approaches are indeed very promising, the ability to understand and defi ne key events and key event relationships will remain one of the more complex and challenging efforts within AOP development. In order to make AOPs useful for risk assessment these challenges need to be understood and overcome. An interdisciplinary approach including apical and molecular measurements, computational, and modeling efforts is currently being one of the most promising approaches to ensure AOPs become the useful framework they were designed to be.
C1 [Perkins, Edward] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Edwards, Stephen; Lyons, David] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Wittwehr, Clemens] Commiss European Communities, Joint Res Ctr, Syst Toxicol Unit, I-21020 Ispra, Italy.
[Villeneuve, Daniel; Ankley, Gerald] US EPA, Midcontinent Ecol Div, Duluth, MN USA.
RP Perkins, E (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RI Lyons, David/G-3459-2011
OI Lyons, David/0000-0002-2966-5634
NR 84
TC 0
Z9 0
U1 4
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1557-2153
BN 978-1-4939-2778-4; 978-1-4939-2777-7
J9 METHOD PHARMACOL TOX
JI Methods Pharmacol. Toxicol.
PY 2015
BP 1
EP 26
DI 10.1007/978-1-4939-2778-4_1
D2 10.1007/978-1-4939-2778-4
PG 26
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE1QP
UT WOS:000368400200002
ER
PT S
AU Fowle, JR
AF Fowle, John Jack R., III
BE Levy, IJ
Middlecamp, CH
TI Harnessing Advances in Biology and Computing To Advance Chemistry: A
Regulatory Toxicology Perspective
SO TEACHING AND LEARNING ABOUT SUSTAINABILITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Sustain-Mix: Sustainabily across the Society / 248th
American-Chemical-Society Meeting and Exposition
CY AUG 10-14, 2014
CL Amer Chem Soc, Div Chem Educ, San Francisco, CA
SP Amer Chem Soc, Div Chem Educ
HO Amer Chem Soc, Div Chem Educ
ID RISK-ASSESSMENT
AB Continuing advances in high speed computing and in the understanding of the biological basis of life have enabled a systems approach to assess chemical toxicity. They provide a promise to more efficiently evaluate risk potential after chemical exposure to humans and the environment, and they also provide a promise to design sustainable chemicals and chemical products. Building on the National Research Council's 2007 report "Toxicity Testing in the 21st Century: A Vision and a Strategy" this chapter presents an overview of the multidisciplinary approaches being developed to integrate science across enabling technologies to develop a mechanistic understanding of toxicology and to use this emerging understanding to predict adverse outcomes. National and international efforts to develop a new paradigm for risk assessment will be mentioned in the context of safe food and drugs, sustainable "green" chemistry, human health and environmental protection.
C1 [Fowle, John Jack R., III] Sci Inform LLC, Pittsboro, NC 27312 USA.
[Fowle, John Jack R., III] US EPA, Washington, DC USA.
RP Fowle, JR (reprint author), Sci Inform LLC, 155 Terrells Mtn, Pittsboro, NC 27312 USA.
EM jackfowle@aol.com
NR 27
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3104-7
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1205
BP 37
EP 58
PG 22
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA BE1OS
UT WOS:000368305400004
ER
PT J
AU Moriasi, DN
Zeckoski, RW
Arnold, JG
Baffaut, CB
Malone, RW
Daggupati, P
Guzman, JA
Saraswat, D
Yuan, Y
Wilson, BW
Shirmohammadi, A
Douglas-Mankin, KR
AF Moriasi, D. N.
Zeckoski, R. W.
Arnold, J. G.
Baffaut, C. B.
Malone, R. W.
Daggupati, P.
Guzman, J. A.
Saraswat, D.
Yuan, Y.
Wilson, B. W.
Shirmohammadi, A.
Douglas-Mankin, K. R.
TI HYDROLOGIC AND WATER QUALITY MODELS: KEY CALIBRATION AND VALIDATION
TOPICS
SO TRANSACTIONS OF THE ASABE
LA English
DT Article
DE ASABE; Calibration; Guidelines; Hydrologic models; Recommendations;
Synthesis; Validation
ID GOODNESS-OF-FIT; UNCERTAINTY; PERFORMANCE; SOIL; METHODOLOGY;
GUIDELINES; SCIENCE
AB As a continuation of efforts to provide a common background and platform for development of calibration and validation (C/V) guidelines for hydrologic and water quality (H/WQ) modeling, ASABE members worked to determine critical topics related to model C/V, perform a synthesis of a previously published special collection of articles and other relevant literature, and provide topic-specific recommendations based on the synthesis as well as personal modeling expertise. This article introduces a special collection of nine research articles covering key topics related to calibration and validation of H/WQ models. The topics include: terminology, hydrologic processes and model representation, spatial and temporal scales, model parameterization, C/V strategies, sensitivity, uncertainty, performance measures and criteria, and documentation and reporting. The main objective of this introductory article is to introduce and summarize key aspects of these topics, including recommendations. Individually, the articles provide model practitioners with detailed topic-specific recommendations related to model calibration, validation, and use. Collectively, the articles present recommendations to enhance H/WQ modeling.
C1 [Moriasi, D. N.] USDA ARS, Grazinglands Res Lab, 7207 W Cheyenne St, El Reno, OK 73036 USA.
[Zeckoski, R. W.] Zeckoski Engn, Charlotte, NC USA.
[Arnold, J. G.] USDA ARS, Grassland Soil & Water Res Lab, Temple, TX USA.
[Baffaut, C. B.] USDA ARS, Cropping Syst & Water Qual Res Unit, Columbia, MO USA.
[Malone, R. W.] USDA ARS, Natl Lab Agr & Environm, Ames, IA USA.
[Daggupati, P.] Texas A&M Univ, Texas Agrilife Res, College Stn, TX USA.
[Guzman, J. A.] Waterborne Environm Inc, Champaign, IL USA.
[Saraswat, D.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA.
[Yuan, Y.] US EPA, Off Res & Dev, NERL ESD Landscape Ecol Branch, Las Vegas, NV USA.
[Wilson, B. W.] Univ Minnesota, Dep Biosyst & Agr Engn, St Paul, MN 55455 USA.
[Shirmohammadi, A.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA.
[Shirmohammadi, A.] Univ Maryland, Maryland Agr Expt Stn, College Pk, MD 20742 USA.
[Douglas-Mankin, K. R.] US Fish & Wildlife Serv, Everglades Program Team, ARM Loxahatchee Natl Wildlife Refuge, Boynton Beach, FL USA.
RP Moriasi, DN (reprint author), USDA ARS, Grazinglands Res Lab, 7207 W Cheyenne St, El Reno, OK 73036 USA.
EM daniel.moriasi@ars.usda.gov
RI Daggupati, Prasad/D-8886-2017
OI Daggupati, Prasad/0000-0002-7044-3435
NR 61
TC 1
Z9 1
U1 6
U2 12
PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS
PI ST JOSEPH
PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA
SN 2151-0032
EI 2151-0040
J9 T ASABE
JI Trans. ASABE
PY 2015
VL 58
IS 6
BP 1609
EP 1618
PG 10
WC Agricultural Engineering
SC Agriculture
GA DB2MC
UT WOS:000368341900016
ER
PT J
AU Yuan, Y
Khare, Y
Wang, X
Parajuli, PB
Kisekka, I
Finsterle, S
AF Yuan, Y.
Khare, Y.
Wang, X.
Parajuli, P. B.
Kisekka, I.
Finsterle, S.
TI HYDROLOGIC AND WATER QUALITY MODELS: SENSITIVITY
SO TRANSACTIONS OF THE ASABE
LA English
DT Article
DE Hydrologic and water quality modeling; One-at-a-time; Parameters;
Sensitivity analysis; Sensitivity measures; Sensitivity methods
ID MIKE-SHE MODEL; SOIL HYDRAULIC-PROPERTIES; GLOBAL SENSITIVITY; SWAT
MODEL; UNCERTAINTY ANALYSES; SIMULATION-MODELS; PARAMETER SENSITIVITY;
DRAINMOD PREDICTIONS; GLUE METHODOLOGY; INPUT VARIABLES
AB This article is part of a collection of articles that provides a comprehensive description of hydrologic and water quality (H/WQ) model calibration and validation concepts and processes. Sensitivity analysis (SA), which is often used to quantify the strength of relationships between model inputs and outputs, is an essential evaluation of any kind of modeling. SA is crucial in H/WQ models due to various aspects involved in H/WQ modeling processes, such as empiricism, spatiotemporal scales, and complexity, that require an assessment of parameters' influence on the model's prediction. This study synthesized SA applications for 25 H/WQ models in the special collection on model use, calibration, and validation published in 2012 and provides guidance on their future applications. Commonly used SA methods are summarized along with tools to implement them. While SA was not employed for all 25 models in the special collection, a wide range of SA methods (from partial derivatives to variance-based global methods) and sensitivity measures (from scatter plots to variance decomposition measures) were used in the literature. Some model parameters were found to be important in most sensitivity applications performed for the models; however, their relative importance varied from study to study, underscoring the necessity of SA for every new model application. Nevertheless, summarizing important model parameters can still serve as a starting point for model users. Since most studies concentrated on model parameters alone; future SA applications in H/WQ modeling should also consider other inputs (climate data, boundary conditions, etc.) and non-parametric aspects, such as features and processes considered in the model.
C1 [Yuan, Y.] US EPA, Off Res & Dev, NERL ESD Landscape Ecol Branch, Las Vegas, NV 89193 USA.
[Khare, Y.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA.
[Wang, X.] Blackland Res & Extens Ctr, Temple, TX USA.
[Parajuli, P. B.] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA.
[Kisekka, I.] Kansas State Univ, Southwest Area Extens, Garden City, KS USA.
[Finsterle, S.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA.
RP Yuan, Y (reprint author), POB 93478,944 East Harmon Ave, Las Vegas, NV 89119 USA.
EM yuan.yongping@epa.gov
RI Finsterle, Stefan/A-8360-2009
OI Finsterle, Stefan/0000-0002-4446-9906
NR 161
TC 8
Z9 8
U1 2
U2 7
PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS
PI ST JOSEPH
PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA
SN 2151-0032
EI 2151-0040
J9 T ASABE
JI Trans. ASABE
PY 2015
VL 58
IS 6
BP 1721
EP 1744
PG 24
WC Agricultural Engineering
SC Agriculture
GA DB2MC
UT WOS:000368341900022
ER
PT J
AU Ghio, AJ
Pavlisko, EN
Roggli, VL
AF Ghio, Andrew J.
Pavlisko, Elizabeth N.
Roggli, Victor L.
TI Iron and Iron-Related Proteins in Asbestosis
SO JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
LA English
DT Article
DE asbestos; asbestosis; iron; divalent metal transporter 1; ferritin;
metal transport protein 1
ID EPITHELIAL-CELLS; LUNG-TISSUE; PATHOGENESIS; TRANSPORTER; EXPRESSION;
GENERATION; INCREASES; CLONING; UPDATE; FE3+
AB We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FPN1). Slides from six individuals having pneumonectomy for lung cancer were employed as controls. Lung tissue from those patients with asbestosis demonstrated stainable iron, whereas control lung tissue did not. Staining for this metal was observed predominantly in airway and alveolar macrophages. Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls. This increased expression of iron-transport and iron-storage proteins was evident in both airway and alveolar epithelial cells. Asbestos bodies were abundant in lung tissue from patients diagnosed to have had asbestosis. While staining for iron, ferruginous bodies did not demonstrate uptake of antibodies for ferritin. DMT1. and FPN1. We conclude that iron homeostasis is altered in lung disease among those diagnosed to have asbestosis with an accumulation of the metal and a modified expression of iron-related proteins being evident.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27711 USA.
Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
RP Ghio, AJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Human Studies Facil, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27711 USA.
EM ghio.andy@epa.gov
FU US Environmental Protection Agency
FX This investigation was funded by the US Environmental Protection Agency.
This report has been reviewed by the National Health and Environmental
Effects Research Laboratory, US Environmental Protection Agency and
approved for publication. Approval does not signify that the contents
necessarily reflect the views and policies of the agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 28
TC 0
Z9 0
U1 1
U2 2
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 0731-8898
EI 2162-6537
J9 J ENVIRON PATHOL TOX
JI J. Environ. Pathol. Toxicol. Oncol.
PY 2015
VL 34
IS 4
BP 277
EP 285
DI 10.1615/JEnvironPatholToxicolOncol.2015013397
PG 9
WC Toxicology
SC Toxicology
GA DB3BM
UT WOS:000368384600001
PM 26756421
ER
PT J
AU Cabezas, H
Heckl, I
Bertok, B
Friedler, F
AF Cabezas, Heriberto
Heckl, Istvan
Bertok, Botond
Friedler, Ferenc
TI Use the P-graph Framework to Design Supply Chains for Sustainability
SO CHEMICAL ENGINEERING PROGRESS
LA English
DT Editorial Material
ID UNCERTAINTY
C1 [Cabezas, Heriberto] US EPA, Washington, DC 20004 USA.
[Cabezas, Heriberto; Heckl, Istvan; Bertok, Botond; Friedler, Ferenc] Univ Pannonia, Pannonia, Hungary.
RP Cabezas, H (reprint author), US EPA, Washington, DC 20004 USA.
NR 14
TC 4
Z9 4
U1 0
U2 0
PU AMER INST CHEMICAL ENGINEERS
PI NEW YORK
PA 3 PARK AVE, NEW YORK, NY 10016-5901 USA
SN 0360-7275
EI 1945-0710
J9 CHEM ENG PROG
JI Chem. Eng. Prog.
PD JAN
PY 2015
VL 111
IS 1
BP 41
EP 47
PG 7
WC Engineering, Chemical
SC Engineering
GA DA5TI
UT WOS:000367865100016
ER
PT J
AU Yu, F
Luo, G
Pryor, SC
Pillai, PR
Lee, SH
Ortega, J
Schwab, JJ
Hallar, AG
Leaitch, WR
Aneja, VP
Smith, JN
Walker, JT
Hogrefe, O
Demerjian, KL
AF Yu, F.
Luo, G.
Pryor, S. C.
Pillai, P. R.
Lee, S. H.
Ortega, J.
Schwab, J. J.
Hallar, A. G.
Leaitch, W. R.
Aneja, V. P.
Smith, J. N.
Walker, J. T.
Hogrefe, O.
Demerjian, K. L.
TI Spring and summer contrast in new particle formation over nine forest
areas in North America
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; SIZE-DISTRIBUTION; ATMOSPHERIC PARTICLES;
OXIDATION-PRODUCTS; NUCLEATION; MODEL; GROWTH; RATES; ACID; UNCERTAINTY
AB Recent laboratory chamber studies indicate a significant role for highly oxidized low-volatility organics in new particle formation (NPF), but the actual role of these highly oxidized low-volatility organics in atmospheric NPF remains uncertain. Here, particle size distributions (PSDs) measured in nine forest areas in North America are used to characterize the occurrence and intensity of NPF and to evaluate model simulations using an empirical formulation in which formation rate is a function of the concentrations of sulfuric acid and low-volatility organics from alpha-pinene oxidation (Nucl-Org), and using an ion-mediated nucleation mechanism (excluding organics) (Nucl-IMN). On average, NPF occurred on similar to 70% of days during March for the four forest sites with springtime PSD measurements, while NPF occurred on only similar to 10% of days in July for all nine forest sites. Both Nucl-Org and Nucl-IMN schemes capture the observed high frequency of NPF in spring, but the Nucl-Org scheme significantly overpredicts while the Nucl-IMN scheme slightly underpredicts NPF and particle number concentrations in summer. Statistical analyses of observed and simulated ultrafine particle number concentrations and frequency of NPF events indicate that the scheme without organics agrees better overall with observations. The two schemes predict quite different nucleation rates (including their spatial patterns), concentrations of cloud condensation nuclei, and aerosol first indirect radiative forcing in North America, highlighting the need to reduce NPF uncertainties in regional and global earth system models.
C1 [Yu, F.; Luo, G.; Schwab, J. J.; Hogrefe, O.; Demerjian, K. L.] SUNY Albany, Atmospher Sci Res Ctr, Albany, NY 12203 USA.
[Luo, G.] Cornell Univ, Dept Earth & Atmospher Sci, Ithaca, NY 14853 USA.
[Pryor, S. C.; Aneja, V. P.; Walker, J. T.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Lee, S. H.] Kent State Univ, Coll Publ Hlth, Kent, OH 44242 USA.
[Ortega, J.; Smith, J. N.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Hallar, A. G.] Desert Res Inst, Storm Peak Lab, Steamboat Springs, CO 80488 USA.
[Leaitch, W. R.] Environm Canada, Sci & Technol Branch, Toronto, ON, Canada.
[Smith, J. N.] Univ Eastern Finland, Dept Appl Phys, Kuopio 70211, Finland.
[Walker, J. T.] US EPA, Off Res & Dev, Durham, NC 27711 USA.
RP Yu, F (reprint author), SUNY Albany, Atmospher Sci Res Ctr, 251 Fuller Rd, Albany, NY 12203 USA.
EM fyu@albany.edu
RI Yu, Fangqun/F-3708-2011; Hallar, Anna Gannet/I-9104-2012; Smith,
James/C-5614-2008;
OI Yu, Fangqun/0000-0003-0874-4883; Hallar, Anna
Gannet/0000-0001-9972-0056; Smith, James/0000-0003-4677-8224; Pryor,
S.C./0000-0003-4847-3440
FU NASA [NNX13AK20G, NNX11AQ72G]; US National Science Foundation (NSF); NSF
[1517365]; US Department of Energy [DE-SC0011664]; NASA's Atmospheric
Chemistry Modeling and Analysis Program
FX This study was supported by NASA under grants NNX13AK20G and NNX11AQ72G,
and the US National Science Foundation (NSF). S. C. Pryor acknowledges
financial support from NSF (no. 1517365). J. J. Schwab acknowledges
funding from the US Department of Energy, contract DE-SC0011664. The
National Center for Atmospheric Research is supported by the US National
Science Foundation. The Steamboat Ski Resort provided logistical support
and in-kind donations to Storm Peak Laboratory. The Desert Research
Institute, which owns and operates Storm Peak Laboratory, is a permittee
of the Medicine-Bow Routt National Forests and is an equal opportunity
service provider and employer. Ian McCubbin provided technical
assistance with the maintenance and data quality control for the aerosol
instruments at SPL, and we are grateful. The GEOS-Chem model is managed
by the Atmospheric Chemistry Modeling Group at Harvard University with
support from NASA's Atmospheric Chemistry Modeling and Analysis Program.
NR 44
TC 3
Z9 3
U1 3
U2 11
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 24
BP 13993
EP 14003
DI 10.5194/acp-15-13993-2015
PG 11
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CZ8YE
UT WOS:000367384200009
ER
PT J
AU Shephard, MW
McLinden, CA
Cady-Pereira, KE
Luo, M
Moussa, SG
Leithead, A
Liggio, J
Staebler, RM
Akingunola, A
Makar, P
Lehr, P
Zhang, J
Henze, DK
Millet, DB
Bash, JO
Zhu, L
Wells, KC
Capps, SL
Chaliyakunnel, S
Gordon, M
Hayden, K
Brook, JR
Wolde, M
Li, SM
AF Shephard, M. W.
McLinden, C. A.
Cady-Pereira, K. E.
Luo, M.
Moussa, S. G.
Leithead, A.
Liggio, J.
Staebler, R. M.
Akingunola, A.
Makar, P.
Lehr, P.
Zhang, J.
Henze, D. K.
Millet, D. B.
Bash, J. O.
Zhu, L.
Wells, K. C.
Capps, S. L.
Chaliyakunnel, S.
Gordon, M.
Hayden, K.
Brook, J. R.
Wolde, M.
Li, S. -M.
TI Tropospheric Emission Spectrometer (TES) satellite observations of
ammonia, methanol, formic acid, and carbon monoxide over the Canadian
oil sands: validation and model evaluation
SO ATMOSPHERIC MEASUREMENT TECHNIQUES
LA English
DT Article
ID REGIONAL AIR-QUALITY; IONIZATION MASS-SPECTROMETER; BIOMASS BURNING
PLUMES; ACETIC-ACIDS; ATMOSPHERIC METHANOL; ORGANIC-COMPOUNDS; GLOBAL
DISTRIBUTIONS; RETRIEVAL ALGORITHM; BIOGENIC EMISSIONS; DAILY MORTALITY
AB The wealth of air quality information provided by satellite infrared observations of ammonia (NH3), carbon monoxide (CO), formic acid (HCOOH), and methanol (CH3OH) is currently being explored and used for a number of applications, especially at regional or global scales. These applications include air quality monitoring, trend analysis, emissions, and model evaluation. This study provides one of the first direct validations of Tropospheric Emission Spectrometer (TES) satellite-retrieved profiles of NH3, CH3OH, and HCOOH through comparisons with coincident aircraft profiles. The comparisons are performed over the Canadian oil sands region during the intensive field campaign (August-September, 2013) in support of the Joint Canada-Alberta Implementation Plan for Oil Sands Monitoring (JOSM). The satellite/aircraft comparisons over this region during this period produced errors of (i) +0.08 +/- 0.25 ppbv for NH3, (ii) +7.5 +/- 23 ppbv for CO, (iii) +0.19 +/- 0.46 ppbv for HCOOH, and (iv) 1.1 +/- 0.39 ppbv for CH3OH. These values mostly agree with previously estimated retrieval errors; however, the relatively large negative bias in CH3OH and the significantly greater positive bias for larger HCOOH and CO values observed during this study warrant further investigation. Satellite and aircraft ammonia observations during the field campaign are also used in an initial effort to perform preliminary evaluations of Environment Canada's Global Environmental Multi-scale-Modelling Air quality and CHemistry (GEM-MACH) air quality modelling system at high resolution (2.5 +/- 2.5 km(2). These initial results indicate a model underprediction of similar to 0.6 ppbv (similar to 60 %) for NH3, during the field campaign period. The TES/model CO comparison differences are similar to+20 ppbv (similar to +20 %), but given that under these conditions the TES/aircraft comparisons also show a small positive TES CO bias indicates that the overall model underprediction of CO is closer to similar to 10% at 681 hPa (similar to 3 km) during this period.
C1 [Shephard, M. W.; McLinden, C. A.; Moussa, S. G.; Leithead, A.; Liggio, J.; Staebler, R. M.; Akingunola, A.; Makar, P.; Lehr, P.; Zhang, J.; Gordon, M.; Hayden, K.; Brook, J. R.; Li, S. -M.] Environm Canada, Toronto, ON, Canada.
[Cady-Pereira, K. E.] AER, Lexington, MA USA.
[Luo, M.] CALTECH, Jet Prop Lab, Pasadena, CA USA.
[Henze, D. K.; Capps, S. L.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
[Millet, D. B.; Wells, K. C.; Chaliyakunnel, S.] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA.
[Bash, J. O.; Capps, S. L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Zhu, L.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA.
[Gordon, M.] York Univ, Dept Earth & Space Sci Engn, Toronto, ON M3J 2R7, Canada.
[Wolde, M.] Natl Res Council NRC Canada, Ottawa, ON, Canada.
RP Shephard, MW (reprint author), Environm Canada, Toronto, ON, Canada.
EM mark.shephard@ec.gc.ca
RI Millet, Dylan/G-5832-2012; Capps, Shannon/E-5602-2017
OI Capps, Shannon/0000-0002-6872-6604
FU NSF [1148951]; Joint Canada-Alberta Implementation Plan for Oil Sands
Monitoring; Clean Air Regulatory Agenda (CARA); NASA ACMAP [NNX10AG63G]
FX We would like to thank Susan S. Kulawik for helping provide us with the
original updated TES version 6 lite files and Craig Stroud for his
helpful discussions and support with the back-trajectory analysis. We
would like to acknowledge other members of the aircraft team for their
contributions to the airborne measurements used to validate the
satellite observations, in particular Andrew Budden, Stewart Cober,
Andrea Darlington, Andrew Elford, Anthony Liu, Peter Liu, Aaron McCay,
Robert McLaren, Bill McMurty, Richard L. Mittermeier, Julie Narayan,
Jason O'Brien, Andrew Sheppard, Ka Sung, Danny Wang, Mohammad Wasey, and
the National Research Council Flight Research Laboratory team. We would
also like thank the other members of the oil sands modelling working
group for their insights on the initial GEM-MACH ammonia simulations
over the oil sands region, in particular Michael Moran. Work at the
University of Minnesota was supported by NSF (grant no. 1148951).
Although this work was reviewed by EPA and approved for publication, it
may not necessarily reflect official agency policy. This study was
supported in part by the Joint Canada-Alberta Implementation Plan for
Oil Sands Monitoring, the Clean Air Regulatory Agenda (CARA), and NASA
ACMAP (grant no. NNX10AG63G).
NR 113
TC 4
Z9 4
U1 8
U2 15
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1867-1381
EI 1867-8548
J9 ATMOS MEAS TECH
JI Atmos. Meas. Tech.
PY 2015
VL 8
IS 12
BP 5189
EP 5211
DI 10.5194/amt-8-5189-2015
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CZ8YI
UT WOS:000367384600011
ER
PT J
AU Baig, RBN
Nadagouda, MN
Varma, RS
AF Baig, R. B. Nasir
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI Cyclic Sulfamidate Enabled Syntheses of Amino Acids, Peptides,
Carbohydrates, and Natural Products
SO ALDRICHIMICA ACTA
LA English
DT Article
DE regiospecific; stereospecific; ring-opening; unnatural amino acid;
chiral building block; natural product; cyclic sulfamidate
ID C-H AMINATION; CATALYZED INTRAMOLECULAR AMIDATION; ASYMMETRIC TRANSFER
HYDROGENATION; ALPHA-PHOSPHONO LACTAMS; STEREOSELECTIVE-SYNTHESIS;
ENANTIOSELECTIVE SYNTHESIS; SULFAMATE ESTERS; BURGESS REAGENT;
NUCLEOPHILIC DISPLACEMENTS; EFFICIENT SYNTHESIS
AB This article reviews the emergence of cyclic sulfamidates as versatile intermediates for the synthesis of unnatural amino acids, chalcogen peptides, modified sugars, drugs and drug candidates, and important natural products.
C1 [Baig, R. B. Nasir; Nadagouda, Mallikarjuna N.; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Baig, RBN (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory
FX R. B. Nasir Baig was supported by the Postgraduate Research Program at
the National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 93
TC 0
Z9 0
U1 3
U2 5
PU ALDRICH CHEMICAL CO INC
PI MILWAUKEE
PA 1001 WEST SAINT PAUL AVE, MILWAUKEE, WI 53233 USA
SN 0002-5100
J9 ALDRICHIM ACTA
JI Aldrichimica Acta
PY 2015
VL 48
IS 3
BP 71
EP 80
PG 10
WC Chemistry, Organic
SC Chemistry
GA CZ2VL
UT WOS:000366962600002
ER
PT J
AU Lalley, J
Han, C
Mohan, GR
Dionysiou, DD
Speth, TF
Garland, J
Nadagouda, MN
AF Lalley, Jacob
Han, Changseok
Mohan, Gayathri Ram
Dionysiou, Dionysios D.
Speth, Thomas F.
Garland, Jay
Nadagouda, Mallikarjuna N.
TI Phosphate removal using modified Bayoxide (R) E33 adsorption media
SO ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
LA English
DT Article
ID GLOBAL PHOSPHORUS FLOWS; AQUEOUS-SOLUTION; RED MUD; IRON-OXIDES;
WASTE-WATER; STEEL SLAG; FLY-ASH; GOETHITE; ADSORBENT; SURFACE
AB The adsorption of phosphate onto modified Bayoxide (R) E33 (E33) and underlying mechanisms were comparatively investigated by batch kinetics, sorption isotherms, rapid small-scale column tests, and material characterization. Synthesis of modified E33 was conducted by the addition of manganese and silver nanoparticles on the surface of the goethite (alpha-FeOOH)-based E33. Upon successful adsorbent synthesis, the materials were characterized using SEM, TEM, XRD, EDX, HR-TEM, and BET surface area analysis. The adsorption kinetics is described by a fast initial adsorption stage followed by a slow adsorption stage, complying with pseudo second-order kinetics and Elovich kinetics. Sorption isotherms revealed that the equilibrium capacity of one of the modified adsorbents (E33/AgII) exceeded that of unmodified E33 likely due to its increased BET surface area. Column experiments confirmed the results for adsorption kinetics and equilibrium of phosphate sorption onto E33 and modified E33. This suggests that media modification has the potential to improve phosphate removal properties.
C1 [Lalley, Jacob; Han, Changseok; Speth, Thomas F.; Nadagouda, Mallikarjuna N.] US EPA, ORD, NRMRL, WSWRD,WQMB, Cincinnati, OH 45268 USA.
[Lalley, Jacob; Dionysiou, Dionysios D.] Univ Cincinnati, DBCEE, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[Han, Changseok; Mohan, Gayathri Ram] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
[Garland, Jay] US EPA, ORD, NERL, MCEARD, Cincinnati, OH 45268 USA.
RP Nadagouda, MN (reprint author), US EPA, ORD, NRMRL, WSWRD,WQMB, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA.
EM Nadagouda.mallikarjuna@epa.gov
NR 64
TC 6
Z9 6
U1 3
U2 6
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2053-1400
EI 2053-1419
J9 ENVIRON SCI-WAT RES
JI Environ. Sci.-Wat. Res. Technol.
PY 2015
VL 1
IS 1
BP 96
EP 107
DI 10.1039/c4ew00020j
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA CZ1UA
UT WOS:000366889800013
ER
PT J
AU Zhu, L
Henze, D
Bash, J
Jeong, GR
Cady-Pereira, K
Shephard, M
Luo, M
Paulot, F
Capps, S
AF Zhu, L.
Henze, D.
Bash, J.
Jeong, G. -R.
Cady-Pereira, K.
Shephard, M.
Luo, M.
Paulot, F.
Capps, S.
TI Global evaluation of ammonia bidirectional exchange and livestock
diurnal variation schemes
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID BIOSPHERE-ATMOSPHERE EXCHANGE; AIR-QUALITY MODEL; UNITED-STATES;
SATELLITE-OBSERVATIONS; DATA ASSIMILATION; HIGH-RESOLUTION; GEOS-CHEM;
TROPOSPHERIC CHEMISTRY; NITROGEN DEPOSITION; PARTICULATE MATTER
AB Bidirectional air-surface exchange of ammonia (NH3) has been neglected in many air quality models. In this study, we implement the bidirectional exchange of NH3 in the GEOS-Chem global chemical transport model. We also introduce an updated diurnal variability scheme for NH3 livestock emissions and evaluate the recently developed MASAGE_NH3 bottom-up inventory. While updated diurnal variability improves comparison of modeled-to-hourly in situ measurements in the southeastern USA, NH3 concentrations decrease throughout the globe, up to 17 ppb in India and southeastern China, with corresponding decreases in aerosol nitrate by up to 7 mu g m(-3). The ammonium (NH4+) soil pool in the bidirectional exchange model largely extends the NH3 lifetime in the atmosphere. Including bidirectional exchange generally increases NH3 gross emissions (7.1 %) and surface concentrations (up to 3.9 ppb) throughout the globe in July, except in India and southeastern China. In April and October, it decreases NH3 gross emissions in the Northern Hemisphere (e.g., 43.6 % in April in China) and increases NH3 gross emissions in the Southern Hemisphere. Bidirectional exchange does not largely impact NH4+ wet deposition overall. While bidirectional exchange is fundamentally a better representation of NH3 emissions from fertilizers, emissions from primary sources are still underestimated and thus significant model biases remain when compared to in situ measurements in the USA. The adjoint of bidirectional exchange has also been developed for the GEOS-Chem model and is used to investigate the sensitivity of NH3 concentrations with respect to soil pH and fertilizer application rate. This study thus lays the groundwork for future inverse modeling studies to more directly constrain these physical processes rather than tuning bulk unidirectional NH3 emissions.
C1 [Zhu, L.; Henze, D.; Jeong, G. -R.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
[Bash, J.; Jeong, G. -R.; Capps, S.] US EPA, Res Triangle Pk, NC USA.
[Cady-Pereira, K.] Atmospher & Environm Res Inc, Lexington, MA USA.
[Shephard, M.] Environm Canada, Toronto, ON, Canada.
[Luo, M.] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA.
[Paulot, F.] Princeton Univ, Program Atmospher & Ocean Sci, Princeton, NJ 08544 USA.
[Paulot, F.] NOAA, Geophys Fluid Dynam Lab, Princeton, NJ USA.
RP Henze, D (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
EM daven.henze@colorado.edu
RI Chem, GEOS/C-5595-2014; Capps, Shannon/E-5602-2017
OI Capps, Shannon/0000-0002-6872-6604
FU NASA [NNX09AN77G, NNX10AG63G]; EPA STAR award [RD834559]
FX This work is supported by NASA grants NNX09AN77G and NNX10AG63G and EPA
STAR award RD834559. While this manuscript has been reviewed by the
Environmental Protection Agency and approved for publication, it may not
reflect official agency views or policies.
NR 68
TC 12
Z9 12
U1 3
U2 24
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 22
BP 12823
EP 12843
DI 10.5194/acp-15-12823-2015
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CX8TM
UT WOS:000365977100008
ER
PT J
AU Gantt, B
Kelly, JT
Bash, JO
AF Gantt, B.
Kelly, J. T.
Bash, J. O.
TI Updating sea spray aerosol emissions in the Community Multiscale Air
Quality (CMAQ) model version 5.0.2
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID PRIMARY MARINE AEROSOL; BOUNDARY-LAYER; SALT AEROSOL;
CHEMICAL-COMPOSITION; RELATIVE-HUMIDITY; WATER TEMPERATURE; SIZE
DISTRIBUTION; UNITED-STATES; NITRIC-ACID; PARTICLES
AB Sea spray aerosols (SSAs) impact the particle mass concentration and gas-particle partitioning in coastal environments, with implications for human and ecosystem health. Model evaluations of SSA emissions have mainly focused on the global scale, but regional-scale evaluations are also important due to the localized impact of SSAs on atmospheric chemistry near the coast. In this study, SSA emissions in the Community Multiscale Air Quality (CMAQ) model were updated to enhance the fine-mode size distribution, include sea surface temperature (SST) dependency, and reduce surf-enhanced emissions. Predictions from the updated CMAQ model and those of the previous release version, CMAQv5.0.2, were evaluated using several coastal and national observational data sets in the continental US. The updated emissions generally reduced model underestimates of sodium, chloride, and nitrate surface concentrations for coastal sites in the Bay Regional Atmospheric Chemistry Experiment (BRACE) near Tampa, Florida. Including SST dependency to the SSA emission parameterization led to increased sodium concentrations in the southeastern US and decreased concentrations along parts of the Pacific coast and northeastern US. The influence of sodium on the gas-particle partitioning of nitrate resulted in higher nitrate particle concentrations in many coastal urban areas due to increased condensation of nitric acid in the updated simulations, potentially affecting the predicted nitrogen deposition in sensitive ecosystems. Application of the updated SSA emissions to the California Research at the Nexus of Air Quality and Climate Change (CalNex) study period resulted in a modest improvement in the predicted surface concentration of sodium and nitrate at several central and southern California coastal sites. This update of SSA emissions enabled a more realistic simulation of the atmospheric chemistry in coastal environments where marine air mixes with urban pollution.
C1 [Gantt, B.; Bash, J. O.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Gantt, B.; Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Bash, JO (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM bash.jesse@epa.gov
RI Kelly, James/F-8135-2010
OI Kelly, James/0000-0001-6574-5714
FU United States Environmental Protection Agency (EPA) through Office of
Research and Development; Office of Research and Development, US EPA
FX We would like to acknowledge use of Rodney Weber's continuous
PM2.5 composition measurements from the Pasadena ground site
and monitor data from the IMPROVE and CSN networks. We also thank
Christopher Nolte for help in the analysis of the BRACE data set/aerosol
size distributions, Kirk Baker for help in the development of the CalNex
platform, and the two anonymous reviewers for their constructive
comments. The United States Environmental Protection Agency (EPA)
through its Office of Research and Development funded and managed the
research described here. This paper has been subjected to the Agency's
administrative review and approved for publication. B. Gantt is
supported by an appointment to the Research Participation Program at the
Office of Research and Development, US EPA, administered by ORISE.
NR 65
TC 5
Z9 5
U1 1
U2 10
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 11
BP 3733
EP 3746
DI 10.5194/gmd-8-3733-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CX8UQ
UT WOS:000365980100013
ER
PT J
AU Mearns, AJ
Reish, DJ
Oshida, PS
Ginn, T
Rempel-Hester, MA
Arthur, C
Rutherford, N
Pryor, R
AF Mearns, Alan J.
Reish, Donald J.
Oshida, Philip S.
Ginn, Thomas
Rempel-Hester, Mary Ann
Arthur, Courtney
Rutherford, Nicolle
Pryor, Rachel
TI Effects of Pollution on Marine Organisms
SO WATER ENVIRONMENT RESEARCH
LA English
DT Article
DE Tissue residues; toxicity; bioaccumulation; biomagnification;
biomarkers; sediment quality; ecological risk assessment; endocrine
disrupters; nano particles; POPs; PCBs; PAHs; PBDEs; radionuclides;
pharmaceuticals; personal care products; trace metals; pesticides;
biomarkers; marine biocides; oil spills; dispersants; sewage; debris;
dredging; eutrophication; human disturbance; Arctic; Antarctic
ID DEEP-WATER-HORIZON; GULF-OF-MEXICO; POLYCYCLIC AROMATIC-HYDROCARBONS;
MEDAKA ORYZIAS-MELASTIGMA; COPEPOD TIGRIOPUS-JAPONICUS; POLYCHAETE
HEDISTE-DIVERSICOLOR; ENDOCRINE-DISRUPTING CHEMICALS; CLAM
VENERUPIS-PHILIPPINARUM; LOGGERHEAD SEA-TURTLES; MUSSEL PERNA-VIRIDIS
AB This review covers selected 2014 articles on the biological effects of pollutants and human physical disturbances on marine and estuarine plants, animals, ecosystems and habitats. The review, based largely on journal articles, covers field and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, dredging and disposal, etc. Special emphasis is placed on effects of oil spills and marine debris due in part to the 2010 Deepwater Horizon oil blowout in the Gulf of Mexico and the 2011 Japanese tsunami. Several topical areas reviewed in the past (ballast water and ocean acidification) were dropped this year. The focus of this review is on effects, not pollutant fate and transport. There is considerable overlap across subject areas (e.g. some bioaccumulation papers may be cited in other topical categories). Please use keyword searching of the text to locate related but distributed papers. Use this review only as a guide and please consult the original papers before citing them.
C1 [Mearns, Alan J.; Rutherford, Nicolle; Pryor, Rachel] NOAA, Emergency Response Div, Seattle, WA 98115 USA.
[Reish, Donald J.] Calif State Univ Long Beach, Dept Biol Sci, Long Beach, CA USA.
[Oshida, Philip S.] US EPA, Arlington, VA USA.
[Ginn, Thomas] Exponent Inc, Sedona, AZ USA.
[Rempel-Hester, Mary Ann] Aquat Toxicol Support, Bremerton, WA USA.
[Arthur, Courtney] Ind Econ Inc, Cambridge, MA USA.
RP Mearns, AJ (reprint author), NOAA, Emergency Response Div, 7600 Sand Point Way NE, Seattle, WA 98115 USA.
EM alan.mearns@noaa.gov
NR 406
TC 2
Z9 2
U1 44
U2 173
PU WATER ENVIRONMENT FEDERATION
PI ALEXANDRIA
PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA
SN 1061-4303
EI 1554-7531
J9 WATER ENVIRON RES
JI Water Environ. Res.
PY 2015
VL 87
IS 10
BP 1718
EP 1816
DI 10.2175/106143015X14338845156380
PG 99
WC Engineering, Environmental; Environmental Sciences; Limnology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater
Biology; Water Resources
GA CY5TB
UT WOS:000366469200032
PM 26420104
ER
PT B
AU Pardo, LH
Robin-Abbott, MJ
Fenn, ME
Goodale, CL
Geiser, LH
Driscoll, CT
Allen, EB
Baron, JS
Bobbink, R
Bowman, WD
Clark, CM
Bowman, WD
Emmett, B
Gilliam, FS
Greaver, TL
Hall, SJ
Lilleskov, EA
Liu, LL
Lynch, JA
Nadelhoffer, KJ
Perakis, SJ
Stoddard, JL
Weathers, KC
Dennis, RL
AF Pardo, Linda H.
Robin-Abbott, Molly J.
Fenn, Mark E.
Goodale, Christine L.
Geiser, Linda H.
Driscoll, Charles T.
Allen, Edith B.
Baron, Jill S.
Bobbink, Roland
Bowman, William D.
Clark, Christopher M.
Bowman, William D.
Emmett, Bridget
Gilliam, Frank S.
Greaver, Tara L.
Hall, Sharon J.
Lilleskov, Erik A.
Liu, Lingli
Lynch, Jason A.
Nadelhoffer, Knute J.
Perakis, Steven J.
Stoddard, John L.
Weathers, Kathleen C.
Dennis, Robin L.
BE DeVries, W
Hettelingh, JP
Posch, M
TI Effects and Empirical Critical Loads of Nitrogen for Ecoregions of the
United States
SO CRITICAL LOADS AND DYNAMIC RISK ASSESSMENTS: NITROGEN, ACIDITY AND
METALS IN TERRESTRIAL AND AQUATIC ECOSYSTEMS
SE Environmental Pollution Series
LA English
DT Article; Book Chapter
ID SAN-BERNARDINO MOUNTAINS; COLORADO FRONT RANGE; TEMPERATE FOREST
ECOSYSTEMS; SOUTHERN-CALIFORNIA; DEPOSITION GRADIENT; ALPINE LAKES;
HERBACEOUS LAYER; RESOURCE REQUIREMENTS; POPULATION-DYNAMICS; MONTANE
ECOSYSTEMS
C1 [Pardo, Linda H.; Robin-Abbott, Molly J.] US Forest Serv, USDA, Burlington, VT USA.
[Fenn, Mark E.] US Forest Serv, USDA, Riverside, CA USA.
[Goodale, Christine L.] Cornell Univ, Ithaca, NY USA.
[Geiser, Linda H.] US Forest Serv, USDA, Corvallis, OR USA.
[Driscoll, Charles T.] Syracuse Univ, Syracuse, NY USA.
[Allen, Edith B.] Univ Calif Riverside, Riverside, CA 92521 USA.
[Baron, Jill S.] US Geol Survey, Ft Collins, CO USA.
[Bobbink, Roland] B WARE Res Ctr, Nijmegen, Netherlands.
[Bowman, William D.] Univ Colorado, Boulder, CO 80309 USA.
[Clark, Christopher M.; Lynch, Jason A.] US EPA, Washington, DC 20460 USA.
[Emmett, Bridget] Environm Ctr Wales, Ctr Ecol & Hydrol, Bangor, Gwynedd, Wales.
[Gilliam, Frank S.] Marshall Univ, Huntington, WV USA.
[Greaver, Tara L.; Liu, Lingli; Dennis, Robin L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Hall, Sharon J.] Arizona State Univ, Tempe, AZ USA.
[Lilleskov, Erik A.] US Forest Serv, USDA, Houghton, MI USA.
[Nadelhoffer, Knute J.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Perakis, Steven J.] US Geol Survey, Corvallis, OR USA.
[Stoddard, John L.] US EPA, Corvallis, OR USA.
[Weathers, Kathleen C.] Cary Inst Ecosyst Studies, Millbrook, NY USA.
RP Pardo, LH (reprint author), US Forest Serv, USDA, Burlington, VT USA.
EM lpardo@fs.fed.us
NR 149
TC 1
Z9 1
U1 6
U2 10
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
BN 978-94-017-9508-1; 978-94-017-9507-4
J9 ENVIRON POLLUT SER
JI Environ. Pollut. Ser.
PY 2015
VL 25
BP 129
EP 169
DI 10.1007/978-94-017-9508-1_5
D2 10.1007/978-94-017-9508-1
PG 41
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BE0AL
UT WOS:000365670800006
ER
PT J
AU Gan, CM
Pleim, J
Mathur, R
Hogrefe, C
Long, CN
Xing, J
Wong, D
Gilliam, R
Wei, C
AF Gan, C. -M.
Pleim, J.
Mathur, R.
Hogrefe, C.
Long, C. N.
Xing, J.
Wong, D.
Gilliam, R.
Wei, C.
TI Assessment of long-term WRF-CMAQ simulations for understanding direct
aerosol effects on radiation "brightening" in the United States
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID NORTH-AMERICA; PART II; MODEL; TRENDS; SYSTEM; PERSPECTIVE; TERRAIN;
SEARCH; DUST
AB Long-term simulations with the coupled WRF-CMAQ (Weather Research and Forecasting-Community Multi-scale Air Quality) model have been conducted to systematically investigate the changes in anthropogenic emissions of SO2 and NOx over the past 16 years (1995-2010) across the United States (US), their impacts on anthropogenic aerosol loading over North America, and subsequent impacts on regional radiation budgets. In particular, this study attempts to determine the consequences of the changes in tropospheric aerosol burden arising from substantial reductions in emissions of SO2 and NOx associated with control measures under the Clean Air Act (CAA) especially on trends in solar radiation. Extensive analyses conducted by Gan et al. (2014a) utilizing observations (e.g., SURFRAD, CASTNET, IMPROVE, and ARM) over the past 16 years (1995-2010) indicate a shortwave (SW) radiation (both all-sky and clear-sky) "brightening" in the US. The relationship of the radiation brightening trend with decreases in the aerosol burden is less apparent in the western US. One of the main reasons for this is that the emission controls under the CAA were aimed primarily at reducing pollutants in areas violating national air quality standards, most of which were located in the eastern US, while the relatively less populated areas in the western US were less polluted at the beginning of this study period. Comparisons of model results with observations of aerosol optical depth (AOD), aerosol concentration, and radiation demonstrate that the coupled WRF-CMAQ model is capable of replicating the trends well even though it tends to underestimate the AOD. In particular, the sulfate concentration predictions were well matched with the observations. The discrepancies found in the clear-sky diffuse SW radiation are likely due to several factors such as the potential increase of ice particles associated with increasing air traffic, the definition of "clear-sky" in the radiation retrieval methodology, and aerosol semi-direct and/or indirect effects which cannot be readily isolated from the observed data.
C1 [Gan, C. -M.; Pleim, J.; Mathur, R.; Hogrefe, C.; Xing, J.; Wong, D.; Gilliam, R.] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Long, C. N.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Long, C. N.] NOAA, Boulder, CO USA.
[Wei, C.] Max Planck Inst Chem, D-55128 Mainz, Germany.
RP Gan, CM (reprint author), US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
EM chuenmeei@gmail.com
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU US EPA; US Department of Energy [IA DE-SC0003782]; US Environmental
Protection Agency [IA RW-89-9233260]; Climate Change Research Division
of the US Department of Energy; Cooperative Institute for Research in
Environmental Sciences (CIRES)
FX This research was performed while Chuen-Meei Gan held a National
Research Council Research Associateship Award at the US EPA. The
research presented in this study was supported through an interagency
agreement between the US Department of Energy (funding IA DE-SC0003782)
and the US Environmental Protection Agency (funding IA RW-89-9233260).
It has been subject to the US EPA's administrative review and approved
for publication. The authors also would like thank John Augustine from
NOAA-SURFRAD for his support and assistance in obtaining the SURFRAD
data, as well as the NOAA Earth System Research Laboratory (ESRL) Global
Monitoring Division (GMD) for their diligent efforts in operating and
maintaining the SURFRAD sites. C. N. Long acknowledges the support of
the Climate Change Research Division of the US Department of Energy as
part of the Atmospheric Radiation Measurement (ARM) and Atmospheric
System Research (ASR) programs, and the support of the Cooperative
Institute for Research in Environmental Sciences (CIRES). The authors
would like thank James Kelly from the US EPA for his comments.
NR 38
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U1 1
U2 3
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 21
BP 12193
EP 12209
DI 10.5194/acp-15-12193-2015
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CW9OV
UT WOS:000365329000005
ER
PT J
AU Gonzalez-Abraham, R
Chung, SH
Avise, J
Lamb, B
Salathe, EP
Nolte, CG
Loughlin, D
Guenther, A
Wiedinmyer, C
Duhl, T
Zhang, Y
Streets, DG
AF Gonzalez-Abraham, R.
Chung, S. H.
Avise, J.
Lamb, B.
Salathe, E. P., Jr.
Nolte, C. G.
Loughlin, D.
Guenther, A.
Wiedinmyer, C.
Duhl, T.
Zhang, Y.
Streets, D. G.
TI The effects of global change upon United States air quality
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID REGIONAL CLIMATE-CHANGE; CMAQ MODELING SYSTEM; FINE PARTICULATE MATTER;
TROPOSPHERIC OZONE; SURFACE OZONE; NORTH-AMERICA; SIMULATING CHANGES;
ISOPRENE EMISSION; PACIFIC-NORTHWEST; EASTERN US
AB To understand more fully the effects of global changes on ambient concentrations of ozone and particulate matter with aerodynamic diameter smaller than 2.5 mu m (PM2.5) in the United States (US), we conducted a comprehensive modeling effort to evaluate explicitly the effects of changes in climate, biogenic emissions, land use and global/regional anthropogenic emissions on ozone and PM2.5 concentrations and composition. Results from the ECHAM5 global climate model driven with the A1B emission scenario from the Intergovernmental Panel on Climate Change (IPCC) were downscaled using the Weather Research and Forecasting (WRF) model to provide regional meteorological fields. We developed air quality simulations using the Community Multiscale Air Quality Model (CMAQ) chemical transport model for two nested domains with 220 and 36 km horizontal grid cell resolution for a semi-hemispheric domain and a continental United States (US) domain, respectively. The semi-hemispheric domain was used to evaluate the impact of projected global emissions changes on US air quality. WRF meteorological fields were used to calculate current (2000s) and future (2050s) biogenic emissions using the Model of Emissions of Gases and Aerosols from Nature (MEGAN). For the semi-hemispheric domain CMAQ simulations, present-day global emissions inventories were used and projected to the 2050s based on the IPCC A1B scenario. Regional anthropogenic emissions were obtained from the US Environmental Protection Agency National Emission Inventory 2002 (EPA NEI2002) and projected to the future using the MARKet ALlocation (MARKAL) energy system model assuming a business as usual scenario that extends current decade emission regulations through 2050. Our results suggest that daily maximum 8 h average ozone (DM8O) concentrations will increase in a range between 2 to 12 parts per billion (ppb) across most of the continental US. The highest increase occurs in the South, Central and Midwest regions of the US due to increases in temperature, enhanced biogenic emissions and changes in land use. The model predicts an average increase of 1-6 ppb in DM8O due to projected increase in global emissions of ozone precursors. The effects of these factors are only partially offset by reductions in DM8O associated with decreasing US anthropogenic emissions. lIncreases in PM2.5 levels between 4 and 10 mu g m(-3) in the Northeast, Southeast, Midwest and South regions are mostly a result of increase in primary anthropogenic particulate matter (PM), enhanced biogenic emissions and land use changes. Changes in boundary conditions shift the composition but do not alter overall simulated PM2.5 mass concentrations.
C1 [Gonzalez-Abraham, R.; Chung, S. H.; Avise, J.; Lamb, B.] Washington State Univ, Pullman, WA 99164 USA.
[Avise, J.] Calif Air Resources Board, Sacramento, CA USA.
[Salathe, E. P., Jr.] Univ Washington Bothell, Bothell, WA USA.
[Nolte, C. G.; Loughlin, D.] US EPA, Res Triangle Pk, NC 27711 USA.
[Guenther, A.; Wiedinmyer, C.; Duhl, T.; Zhang, Y.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Streets, D. G.] Argonne Natl Lab, Argonne, IL 60439 USA.
RP Gonzalez-Abraham, R (reprint author), Portland State Univ, Portland, OR 97207 USA.
EM arodrigo@pdx.edu
RI Nolte, Christopher/H-4345-2012
OI Nolte, Christopher/0000-0001-5224-9965
FU US Environmental Protection Agency Science To Achieve Results grants [RD
83336901-0, 838309621-0]
FX This work was supported by the US Environmental Protection Agency
Science To Achieve Results grants RD 83336901-0 and 838309621-0. This
paper has been cleared by the EPA's administrative review process and
approved for publication. The views expressed in this paper are those of
the authors and do not necessarily reflect the views or policies of the
US Environmental Protection Agency.
NR 99
TC 4
Z9 4
U1 5
U2 19
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 21
BP 12645
EP 12665
DI 10.5194/acp-15-12645-2015
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CW9OV
UT WOS:000365329000028
ER
PT S
AU Postigo, C
Jeong, CH
Richardson, SD
Wagner, ED
Plewa, MJ
Simmons, JE
Barcelo, D
AF Postigo, Cristina
Jeong, Clara H.
Richardson, Susan D.
Wagner, Elizabeth D.
Plewa, Michael J.
Simmons, Jane Ellen
Barcelo, Damia
BE Karanfil, T
Mitch, B
Westerhoff, P
Xie, Y
TI Analysis, Occurrence, and Toxicity of Haloacetaldehydes in Drinking
Waters: Iodoacetaldehyde as an Emerging Disinfection By-Product
SO RECENT ADVANCES IN DISINFECTION BY-PRODUCTS
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Occurrence, Formation, Health Effects and Control of
Disinfection By-Products in Drinking Water / 248th ACS National Meeting
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc, Div Environm Chem, Water Res Fdn
DE disinfection by-products; genotoxicity; cytotoxicity; occurrence;
drinking waters; halogenated aldehydes; chloral hydrate; mammalian cells
ID NATURAL ORGANIC-MATTER; HAMSTER OVARY CELLS; SWIMMING POOL WATER;
CHLORINE DIOXIDE; HALOGENATED ACETALDEHYDES; ASPERGILLUS-NIDULANS;
TREATED WATER; COMET ASSAY; CHLORAMINATION; REMOVAL
AB Chlorinated and brominated haloacetaldehydes (HALs) are considered the 3rd largest class of disinfection by-products (DBPs) by weight. The iodinated HAL, iodoacetaldehyde, has been recently reported as an emerging DBP in finished drinking waters. Overall, iodinated DBPs, e.g., iodoacetic acids, iodoacetamides, and iodonitriles, are among the most genotoxic of all DBPs identified. In this context, this chapter reviews the analytical methods available to date to determine HALs in water, and the concentrations at which they are present in finished drinking waters. Since systematic toxicological effects have been only investigated for selected chloro- and bromo- HALs, a comparative study of the genotoxicity and cytotoxicity of this DBP class to mammalian cells is also presented.
C1 [Postigo, Cristina; Barcelo, Damia] IDAEA CSIC, Inst Environm Assessment & WaterRes, Dept Environm Chem, Barcelona 08034, Spain.
[Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA.
[Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Safe Global Water Inst, Ctr Adv Mat Purificat Water Syst, Urbana, IL 61801 USA.
[Richardson, Susan D.] Univ S Carolina, JM Palms Ctr GSR, Dept Chem & Biochem, Columbia, SC 29208 USA.
[Simmons, Jane Ellen] US EPA, NHEERL, Res Triangle Pk, NC 27709 USA.
[Barcelo, Damia] Univ Girona, Catalan Inst Water Res ICRA, Girona 17003, Spain.
RP Postigo, C (reprint author), IDAEA CSIC, Inst Environm Assessment & WaterRes, Dept Environm Chem, Carrer Jordi Girona 18-26, Barcelona 08034, Spain.
EM cprqam@cid.csic.es
RI Postigo, Cristina/H-7876-2015
OI Postigo, Cristina/0000-0002-7344-7044
NR 68
TC 0
Z9 0
U1 9
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3076-7
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1190
BP 25
EP 43
PG 19
WC Engineering, Environmental; Environmental Sciences; Toxicology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Toxicology; Water
Resources
GA BD9TH
UT WOS:000365248800002
ER
PT J
AU Schreinemachers, DM
Ghio, AJ
Sobus, JR
Williams, MA
AF Schreinemachers, Dina M.
Ghio, Andrew J.
Sobus, Jon R.
Williams, Marc A.
TI Perchlorate Exposure is Associated with Oxidative Stress and Indicators
of Serum Iron Homeostasis Among NHANES 2005-2008 Subjects
SO BIOMARKER INSIGHTS
LA English
DT Article
DE perchlorate; epidemiology; biomarkers; iron homeostasis
ID THYROID-HORMONE LEVELS; URIC-ACID; DEFICIENCY; METABOLISM; FERRITIN;
HEALTH; HYPOTHYROIDISM; TECHNOLOGIES; INFLAMMATION; REMOVAL
AB Perchlorate (ClO4?), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 20052008 National Health and Nutrition Examination Surveys, investigated associations between urinary perchlorate and biomarkers of iron homeostasis, lipids, blood cell counts, and glucose metabolism. Healthy males (n = 3705), non-pregnant females (n = 2967), and pregnant females (n = 356), aged 1259 years, were included in the linear regression models, which showed significant positive (+) and negative (-) associations for both males and non-pregnant females with serum uric acid (-), serum iron (-), RBC count (-), blood urea nitrogen (+), and lymphocyte count (+). Other significant associations were observed for either males or non-pregnant females. Among pregnant females, perchlorate was significantly associated with blood urea nitrogen (+) and serum iron (-). These associations may be indicators of perchlorate's potential effect on several biological systems, which when considered in total, may implicate perturbation of iron homeostasis.
C1 [Schreinemachers, Dina M.; Ghio, Andrew J.; Williams, Marc A.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, ORD, Durham, NC 27709 USA.
[Sobus, Jon R.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, ORD, Durham, NC USA.
RP Schreinemachers, DM (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, ORD, Durham, NC 27709 USA.
EM schreinemachers.dina@epa.gov
NR 45
TC 4
Z9 4
U1 0
U2 1
PU LIBERTAS ACAD
PI AUCKLAND
PA PO BOX 300-874, ALBANY 0752, AUCKLAND, 00000, NEW ZEALAND
SN 1177-2719
J9 BIOMARK INSIGHTS
JI Biomark. Insights
PY 2015
VL 10
BP 9
EP 19
DI 10.4137/BMI.320089
PG 11
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CW6LW
UT WOS:000365110000001
PM 25673971
ER
PT J
AU Sharma, VK
Filip, J
Zboril, R
Varma, RS
AF Sharma, Virender K.
Filip, Jan
Zboril, Radek
Varma, Rajender S.
TI Natural inorganic nanoparticles - formation, fate, and toxicity in the
environment
SO CHEMICAL SOCIETY REVIEWS
LA English
DT Review
ID DISSOLVED ORGANIC-MATTER; SILVER NANOPARTICLES; ANTIBACTERIAL ACTIVITY;
GOLD NANOPARTICLES; ENGINEERED NANOPARTICLES; SURFACE-CHARGE; STABILITY;
REDUCTION; TRANSFORMATION; SYSTEMS
AB The synthesis, stability, and toxicity of engineered metal nanoparticles (ENPs) have been extensively studied during the past two decades. In contrast, research on the formation, fate, and ecological effects of naturally-occurring nanoparticles (NNPs) has become a focus of attention only recently. The natural existence of metal nanoparticles and their oxides/sulfides in waters, wastewaters, ore deposits, mining regions, and hydrothermal vents, as exemplified by the formation of nanoparticles containing silver and gold (AgNPs and AuNPs), Fe, Mn, pyrite (FeS2), Ag2S, CuS, CdS, and ZnS, is dictated largely by environmental conditions (temperature, pH, oxic/anoxic, light, and concentration and characteristics of natural organic matter (NOM)). Examples include the formation of nanoparticles containing pyrite, Cu and Zn-containing pyrite, and iron in hydrothermal vent black smoker emissions. Metal sulfide nanoparticles can be formed directly from their precursor ions or indirectly by sulfide ion-assisted transformation of the corresponding metal oxides under anaerobic conditions. This tutorial focuses on the formation mechanisms, fate, and toxicity of natural metal nanoparticles. Natural waters containing Ag(I) and Au(III) ions in the presence of NOM generate AgNPs and AuNPs under thermal, non-thermal, and photochemical conditions. These processes are significantly accelerated by existing redox species of iron (Fe(II)/Fe(III)). NOM, metal-NOM complexes, and reactive oxygen species (ROS) such as O-2(center dot-), (OH)-O-center dot, and H2O2 are largely responsible for the natural occurrence of nanoparticles. AgNPs and AuNPs emanating from Ag(I)/Au(III)-NOM reactions are stable for several months, thus indicating their potential to be transported over long distances from their point of origin. However, endogenous cations present in natural waters can destabilize the nanoparticles, with divalent cations (e.g., Ca2+, Mg2+) being more influential than their monovalent equivalents (e.g., Na+, K+). The toxicity of NNPs may differ from that of ENPs because of differences in the coatings on the nanoparticle surfaces. An example of this phenomenon is presented and is briefly discussed.
C1 [Sharma, Virender K.] Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA.
[Filip, Jan; Zboril, Radek; Varma, Rajender S.] Palacky Univ, Reg Ctr Adv Technol & Mat, Dept Expt Phys, Olomouc 77146, Czech Republic.
[Filip, Jan; Zboril, Radek; Varma, Rajender S.] Palacky Univ, Dept Phys Chem, Fac Sci, Olomouc 77146, Czech Republic.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sharma, VK (reprint author), Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA.
EM vsharma@sph.tamhsc.edu; Varma.Rajender@epa.gov
RI Zboril, Radek/F-5153-2015;
OI Sharma, Virender/0000-0002-5980-8675; Zboril, Radek/0000-0002-3147-2196
FU Ministry of Education, Youth and Sports of the Czech Republic [LO1305];
Technology Agency of the Czech Republic "Competence Centers''
[TE01020218]
FX V.K. Sharma, J. Filip, and R. Zboril acknowledge the support by the
Ministry of Education, Youth and Sports of the Czech Republic (project
LO1305) and Technology Agency of the Czech Republic "Competence
Centers'' (project No. TE01020218). We thank Dr. Leslie Cizmas and Dr.
John Leazer for their comments to improve the article.
NR 53
TC 20
Z9 20
U1 42
U2 191
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 0306-0012
EI 1460-4744
J9 CHEM SOC REV
JI Chem. Soc. Rev.
PY 2015
VL 44
IS 23
BP 8410
EP 8423
DI 10.1039/c5cs00236b
PG 14
WC Chemistry, Multidisciplinary
SC Chemistry
GA CW2WI
UT WOS:000364853400003
PM 26435358
ER
PT J
AU Nolte, CG
Appel, KW
Kelly, JT
Bhave, PV
Fahey, KM
Collett, JL
Zhang, L
Young, JO
AF Nolte, C. G.
Appel, K. W.
Kelly, J. T.
Bhave, P. V.
Fahey, K. M.
Collett, J. L., Jr.
Zhang, L.
Young, J. O.
TI Evaluation of the Community Multiscale Air Quality (CMAQ) model v5.0
against size-resolved measurements of inorganic particle composition
across sites in North America
SO Geoscientific Model Development
LA English
DT Article
ID ATMOSPHERIC BOUNDARY-LAYER; FINE PARTICULATE MATTER; NONLOCAL
CLOSURE-MODEL; UNITED-STATES; SEA-SALT; PERFORMANCE EVALUATION; RURAL
LOCATIONS; AEROSOL; IMPACT; SYSTEM
AB This work evaluates particle size-composition distributions simulated by the Community Multiscale Air Quality (CMAQ) model using micro-orifice uniform deposit impactor (MOUDI) measurements at 18 sites across North America. Size-resolved measurements of particulate SO42-, NO3-, NH4+, Na+, Cl-, Mg2+, Ca2+, and K+ are compared to CMAQ model output for discrete sampling periods between 2002 and 2005. The observation sites were predominantly in remote areas (e.g., National Parks) in the USA and Canada, and measurements were typically made for a period of roughly 1 month. For SO42- and NH4+, model performance was consistent across the USA and Canadian sites, with the model slightly overestimating the peak particle diameter and underestimating the peak particle concentration compared to the observations. Na+ and Mg2+ size distributions were generally well represented at coastal sites, indicating reasonable simulation of emissions from sea spray. CMAQ is able to simulate the displacement of Cl- in aged sea spray aerosol, though the extent of Cl- depletion relative to Na+ is often underpredicted. The model performance for NO3- exhibited much more site-to-site variability than that of SO42- and NH4+, with the model ranging from an underestimation to overestimation of both the peak diameter and peak particle concentration across the sites. Computing PM2.5 from the modeled size distribution parameters rather than by summing the masses in the Aitken and accumulation modes resulted in differences in daily averages of up to 1 mu gm(-3) (10 %), while the difference in seasonal and annual model performance compared to observations from the Interagency Monitoring of Protected Visual Environments (IMPROVE), Chemical Speciation Network (CSN), and Air Quality System (AQS) networks was very small. Two updates to the CMAQ aerosol model - changes to the assumed size and mode width of emitted particles and the implementation of gravitational settling - resulted in small improvements in modeled size distributions.
C1 [Nolte, C. G.; Appel, K. W.; Fahey, K. M.; Young, J. O.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA.
[Bhave, P. V.] Int Ctr Integrated Mt Dev, Khumaltar, Lalitpur, Nepal.
[Collett, J. L., Jr.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA.
[Zhang, L.] Environm Canada, Sci & Technol Branch, Air Qual Res Div, Toronto, ON, Canada.
RP Nolte, CG (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
EM nolte.chris@epa.gov
RI Nolte, Christopher/H-4345-2012; Kelly, James/F-8135-2010; Collett,
Jeffrey/F-2862-2010
OI Nolte, Christopher/0000-0001-5224-9965; Kelly,
James/0000-0001-6574-5714; Collett, Jeffrey/0000-0001-9180-508X
FU United States Environmental Protection Agency through its Office of
Research and Development
FX We thank Taehyoung Lee (Colorado State University), Noreen Poor
(University of South Florida), and Charles Stanier (University of Iowa)
for providing MOUDI measurements that helped make this analysis
possible. Brett Gantt and Rohit Mathur (US EPA) provided constructive
comments in reviewing this manuscript. We thank Heather Simon and George
Pouliot (US EPA) for their assistance with PM profiles in the SPECIATE
database. The United States Environmental Protection Agency through its
Office of Research and Development supported the research described
here. It has been subjected to Agency review and approved for
publication. The views and interpretations in this publication are those
of the authors and are not necessarily attributable to their
organizations.
NR 57
TC 7
Z9 7
U1 2
U2 16
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 9
BP 2877
EP 2892
DI 10.5194/gmd-8-2877-2015
PG 16
WC Geosciences, Multidisciplinary
SC Geology
GA CV5QJ
UT WOS:000364325700010
ER
PT S
AU Lau, C
AF Lau, Christopher
BE DeWitt, JC
TI Perfluorinated Compounds: An Overview
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Perfluoroalkyl acids; Toxicology; Health effects; Epidemiology; Overview
ID PERFLUOROOCTANE SULFONATE PFOS; PERFLUOROALKYL ACIDS PFAAS; GLOBAL
EMISSION INVENTORIES; ACTIVATED RECEPTOR-ALPHA; 2 GERMAN CITIES;
TEMPORAL TRENDS; HUMAN EXPOSURE; FRESH-WATER; POLYFLUOROALKYL
SUBSTANCES; PHOSPHONIC-ACIDS
AB This chapter provides an overarching introduction to the subject matter of this volume: toxicology and health effects of perfluorinated compounds (PFCs). It highlights briefly the unique chemical and physical properties of these chemicals, their production history and commercial uses, and their environmental and health concerns. The distribution profiles of these persistent contaminants in environmental media, wildlife and humans, as well as potential pathways of human exposure are characterized. General toxicological features of these chemicals include major species and sex differences in pharmacokinetic disposition among congeners with different carbon-chain lengths and functional groups, and differential potencies based on their primary mechanism of action, i.e., activation of the nuclear receptor PPARoc. Current understanding of adverse effects associated with PFC exposure based on laboratory animal models include hepatotoxicity, tumor induction, developmental toxicity, immunotoxicity, neurotoxicity and endocrine disruption. Associations and probable links between exposure to some PFCs and adverse health outcomes in humans have been suggested by recent epidemiological reports. Ecological and human health risk assessments of these chemicals are still in their infancy. Each of these sub-topics will be expanded into full discussion in subsequent chapters. Importantly, a new generation of fluorinated chemicals has already emerged in commerce, with little information regarding their environmental fate and distribution as well as potential health effects. Materials presented in this volume should provide a scientific basis to inform the design of safe replacement products for the current crop of perfluorinated chemicals that promises to be less persistent and prevalent in the environment.
C1 US EPA, Dev Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
RP Lau, C (reprint author), US EPA, Dev Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Mail Drop B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lau.christopher@epa.gov
NR 175
TC 5
Z9 5
U1 4
U2 15
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 1
EP 21
DI 10.1007/978-3-319-15518-0_1
D2 10.1007/978-3-319-15518-0
PG 21
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700002
ER
PT S
AU Abbott, BD
AF Abbott, Barbara D.
BE DeWitt, JC
TI Developmental Toxicity
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Developmental toxicity; Teratology; Peroxisome proliferator activated
receptor (PPAR); Postnatal toxicity
ID PROLIFERATOR-ACTIVATED RECEPTORS; AMMONIUM PERFLUOROOCTANOATE APFO;
RESTRICTED GESTATIONAL EXPOSURES; ORGANIC ANION TRANSPORTERS;
MAMMARY-GLAND DEVELOPMENT; SPRAGUE-DAWLEY RATS; ALPHA PPAR-ALPHA;
PERFLUOROALKYL ACIDS; CROSS-FOSTER; PERFLUORINATED COMPOUNDS
AB This chapter provides an overview of the developmental toxicity resulting from exposure to perfluorinated alkyl acids (PFAAs). The majority of studies of PFAA-induced developmental toxicity have examined effects of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA) and there is only limited information available for other members of this family of chemicals. In this chapter, there are separate overviews of the developmental toxicity of PFOS and PFOA, along with a summary of studies available for perfluorobutyrate (PFBA), perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). In general, among the PFAAs that do produce developmental toxicity in one or more laboratory species, prenatal PFAA exposure in teratology studies typically does not result in major malformations and significant findings are often limited to the higher exposure levels. The postnatal effects in rats or mice exposed to PFAAs are typically increased mortality in the first hours or week after birth, effects on weight which may persist beyond weaning, delayed eye opening, abnormal mammary gland development, and liver hypertrophy. The role of peroxisome proliferator activated receptor-alpha (PPARoc) in mediating developmental effects is discussed, including insights from genetically modified mice, PPARoc knockout mice, and mice expressing the human PPARoc gene. Pharmacokinetic issues are relevant to selecting an appropriate animal model for developmental studies and regarding the influence of rapid clearance on manifestation of developmental toxicity. Whether or not a particular PFAA will cause developmental toxicity depends on levels and timing of fetal exposure and is influenced by species and gender specific pharmacokinetic characteristics that impact exposure of the conceptus throughout gestation and during the lactational period. Factors influencing the pharmacokinetics and developmental outcomes include chemical characteristics of a particular PFAA (carbon chain length, functional moiety carboxylate or sulfonate), species specific characteristics (sex and species specific expression of particular transporters in the kidney that influence clearance), timing and level of exposure to the developing fetus, and ability of the PFAA to activate PPARoc (human, mouse, and rat PPAR alpha differ in responses to PFAA, carboxylates are more effective than sulfonates, and longer carbon chain PFAA are more potent than short chain PFAA). The expression and activation of PPAR alpha is necessary for mediating developmental effects of PFOA and PFNA, but the early postnatal deaths caused by exposure to PFOS were not dependent on expression of PPAR alpha.
C1 US EPA, Tox Assessment Div B10504, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Abbott, BD (reprint author), US EPA, Tox Assessment Div B10504, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Abbott.barbara@epa.gov
NR 56
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 203
EP 218
DI 10.1007/978-3-319-15518-0_8
D2 10.1007/978-3-319-15518-0
PG 16
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700009
ER
PT S
AU Wambaugh, J
AF Wambaugh, John
BE DeWitt, JC
TI Dosimetric Anchoring of Toxicological Studies
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Pharmacokinetics; Dosimetric anchor; Mathematical models; Extrapolation;
Dose regimen; Biological variability
ID AMMONIUM PERFLUOROOCTANOATE APFO; ORGANIC ANION TRANSPORTERS;
THYROID-HORMONE STATUS; POTASSIUM PERFLUOROOCTANESULFONATE; COMPARATIVE
PHARMACOKINETICS; CYNOMOLGUS MONKEYS; 2-GENERATION REPRODUCTION;
DEVELOPMENTAL TOXICITY; LACTATIONAL EXPOSURE; PERFLUOROALKYL ACIDS
AB Comparing the onset of effects between different toxicological studies is often confounded by pharmacokinetics (PK). Differences between studies can be biological in origin (e.g. species, gender) as well as due to dose regimen (e.g. spacing, magnitude, duration, and route of administration). However, if the pharmacodynamic mechanism underlying the observed toxicological effect is conserved, and some measure of the tissue concentration (i.e., dos imetry) at the site of effect can be determined, then it is expected that this dosimetric anchor should also be conserved across studies. Careful consideration of the PK is required, and mathematical models for PK can address this need. It is relatively easy to extrapolate model predictions if there is a reasonable expectation of linear behavior and conserved PK between test conditions and those to be predicted. For perfluorinated compounds (PFCs), however, we expect PK extrapolation to be much more difficult. Aspects of the distribution, metabolism, and elimination of PFCs have unusual and non-linear features that must be considered. The PK of PFCs is especially unusual in that the half-lives of the longer chain PFCs vary by many orders of magnitude across species, dose regimen, and in some cases, across gender. The empirical saturable renal resorption hypothesis of the Andersen et al. (Toxicol 227(16978759):156-164, 2006) model provides the simplest available non-linear PK model that describes PFCs PK. However, despite the plausible biological mechanism, this model is still empirical, requiring that species-specific parameters are estimated using species-specific PK data. With this model, diverse toxicological studies of PFCs can be shown to be roughly consistent with respect to the internal, dosimetric anchors induced by their various study designs.
C1 US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Wambaugh, J (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Mail Drop B205-01 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Wambaugh.john@epa.gov
OI Wambaugh, John/0000-0002-4024-534X
NR 93
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 337
EP 361
DI 10.1007/978-3-319-15518-0_14
D2 10.1007/978-3-319-15518-0
PG 25
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700015
ER
PT J
AU Wang, C
Cyterski, M
Feng, YJ
Gao, P
Sun, QF
AF Wang, Ce
Cyterski, Mike
Feng, Yujie
Gao, Peng
Sun, Qingfang
TI Spatiotemporal characteristics of organic contaminant concentrations and
ecological risk assessment in the Songhua River, China
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; STATISTICAL TECHNIQUES; AQUATIC
ORGANISMS; TRANSPORT MODEL; WATER; POLLUTION; FATE; SEDIMENTS; RESIDUES;
QUANTIFY
AB To control source pollution and improve water quality, an understanding of the spatiotemporal characteristics of organic contaminant concentrations in affected receiving waters is necessary. The Songhua River in northeast China is the country's third-largest domestic river and loadings of organic contaminants along an industrialized section have made it the focal point of a national pollution reduction plan. In addition to water quality issues, management of the Songhua River basin must also address local economic development, aquatic ecosystem sustainability and political relationships with Russia. In three periods spanning 2006 to 2010, eight polycyclic aromatic hydrocarbons (PAHs) and eight phenols were measured in surface waters at ten monitoring sites along the river. A generalized linear model (GLM) was used to characterize water quality at different sites and time periods. Chemical concentrations of the organic compounds showed significant sinusoidal seasonal patterns and the concentrations declined significantly from 2006 to 2010, possibly due to management practices designed to control water pollution. A critical body residue analysis showed that water concentrations measured during the winter of 2007 across all monitoring sites, but especially at S1-Shaokou and S2-Songhuajiangcun, presented a high risk for fish species. The spatiotemporal characteristics of water quality and estimated ecological risks shown here add to the body of knowledge to develop policies on industrial output and pollution management strategies for the Songhua River basin.
C1 [Wang, Ce] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China.
[Cyterski, Mike] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, New York, NY USA.
[Feng, Yujie; Gao, Peng; Sun, Qingfang] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Peoples R China.
RP Wang, C (reprint author), Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China.
EM wangce@nju.edu.cn; cyterski.mike@epa.gov
RI Wang, Ce/B-2500-2012
OI Wang, Ce/0000-0001-6244-1205
FU Major Science and Technology Program for Water Pollution Control and
Treatment [2012ZX07506-004-004]; Fundamental Research Funds for the
Central Universities [20620140481]; National Scientific Fund for
Distinguished Young Scholars [51125033]; Funds for Creative Research
Group of China [51121062]
FX This research was supported by the Major Science and Technology Program
for Water Pollution Control and Treatment (2012ZX07506-004-004),
Fundamental Research Funds for the Central Universities (20620140481),
National Scientific Fund for Distinguished Young Scholars (51125033) and
Funds for Creative Research Group of China (51121062). We thank Tao
Hong, USEPA, for analytical assistance, Fran Rauschenberg, USEPA, for
insightful editorial suggestions, and Yang Tao, Geomatics Center of
Jiangsu Province of China, for GIS processing.
NR 33
TC 1
Z9 1
U1 3
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 11
BP 1967
EP 1975
DI 10.1039/c5em00375j
PG 9
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CV3GK
UT WOS:000364146800011
PM 26442573
ER
PT J
AU He, YT
Su, CM
AF He, Yongtian Thomas
Su, Chunming
BE Shiomi, N
TI Use of Additives in Bioremediation of Contaminated Groundwater and Soil
SO ADVANCES IN BIOREMEDIATION OF WASTEWATER AND POLLUTED SOIL
LA English
DT Article; Book Chapter
DE Organic contaminants; carbon substrates; additives; bioremediation
implementation; potential issues
ID VINYL-CHLORIDE; SUBSURFACE REMEDIATION; TETRACHLOROETHENE;
BIOAUGMENTATION; DETOXIFICATION; DECHLORINATION; HYDROCARBONS;
SURFACTANTS; TOXICITY; KINETICS
AB This chapter reviews the application of additives used in bioremediation of chlorinated solvents and fuels for groundwater and soil remediation. Soluble carbon substrates are applicable to most site conditions except aquifers with very high or very low groundwater flow. Slow-release and solid substrates are intended to be long-lasting in supplying carbon for microbial growth thereby minimizing operation and maintenance requirements. Microbes as special additives can be used to enhance bioremediation (bioaugmentation) where such microbes are lacking. Oxygen gas can be added to increase aerobic biodegradation, and nutrients addition may be needed to stimulate and maintain sufficient microbial population. pH modifiers to control acidity for optimal microbial growth and degradation can also be added. Delivery of additives to the subsurface can he accomplished through permanent injection wells, direct-push methods, or permeable reactive barriers (biowall). Potential issues with additive use include biofouling, stalling, short circuiting, displacement, reduced hydraulic conductivity, and secondary water quality deterioration. Methods and techniques to deal with these issues are provided and future research needs are identified.
C1 [He, Yongtian Thomas] W Virginia Univ, West Virginia Water Res Inst, Morgantown, WV 26506 USA.
[Su, Chunming] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
RP Su, CM (reprint author), US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
EM Su.Chunming@epa.gov
NR 42
TC 0
Z9 0
U1 3
U2 6
PU INTECH EUROPE
PI RIJEKA
PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA
BN 978-953-51-2165-7
PY 2015
BP 145
EP 164
DI 10.5772/60915
D2 10.5772/59328
PG 20
WC Biotechnology & Applied Microbiology; Engineering, Environmental; Water
Resources
SC Biotechnology & Applied Microbiology; Engineering; Water Resources
GA BD7XR
UT WOS:000363679000008
ER
PT J
AU Verma, S
Baig, RBN
Han, C
Nadagouda, MN
Varma, RS
AF Verma, Sanny
Baig, R. B. Nasir
Han, Changseok
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI Magnetic graphitic carbon nitride: its application in the C-H activation
of amines
SO CHEMICAL COMMUNICATIONS
LA English
DT Article
ID CATALYZED OXIDATIVE CYANATION; TERTIARY-AMINES; SODIUM-CYANIDE;
SUSTAINABLE APPLICATIONS; HYDROGEN-PEROXIDE; BOND ACTIVATION; GREEN
CHEMISTRY; 3-AROYLINDOLES; FUTURE
AB Magnetic graphitic carbon nitride, Fe@g-C3N4, has been synthesized by adorning a graphitic carbon nitride (g-C3N4) support with iron oxide via non-covalent interaction. The magnetically recyclable catalyst showed excellent reactivity for the expeditious C-H activation and cyanation of amines.
C1 [Verma, Sanny; Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Han, Changseok; Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
FU U.S. Department of Energy; U.S. Environmental Protection Agency
FX SV and RBNB were supported by the Postgraduate Research Program at the
National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 34
TC 20
Z9 20
U1 12
U2 48
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1359-7345
EI 1364-548X
J9 CHEM COMMUN
JI Chem. Commun.
PY 2015
VL 51
IS 85
BP 15554
EP 15557
DI 10.1039/c5cc05895c
PG 4
WC Chemistry, Multidisciplinary
SC Chemistry
GA CT9WS
UT WOS:000363167900018
PM 26352198
ER
PT J
AU Gawande, MB
Goswami, A
Asefa, T
Guo, HZ
Biradar, AV
Peng, DL
Zboril, R
Varma, RS
AF Gawande, Manoj B.
Goswami, Anandarup
Asefa, Tewodros
Guo, Huizhang
Biradar, Ankush V.
Peng, Dong-Liang
Zboril, Radek
Varma, Rajender S.
TI Core-shell nanoparticles: synthesis and applications in catalysis and
electrocatalysis
SO CHEMICAL SOCIETY REVIEWS
LA English
DT Review
ID OXYGEN REDUCTION REACTION; CROSS-COUPLING REACTIONS; LITHIUM-ION
BATTERIES; ONE-POT SYNTHESIS; CORE/SHELL HIERARCHICAL NANOSTRUCTURES;
ASYMMETRIC TRANSFER HYDROGENATION; ENHANCED PHOTOCATALYTIC ACTIVITY;
STRUCTURED MESOPOROUS SILICA; SURFACE ELECTRONIC-STRUCTURE; METAL-FREE
ELECTROCATALYSTS
AB Core-shell nanoparticles (CSNs) are a class of nanostructured materials that have recently received increased attention owing to their interesting properties and broad range of applications in catalysis, biology, materials chemistry and sensors. By rationally tuning the cores as well as the shells of such materials, a range of core-shell nanoparticles can be produced with tailorable properties that can play important roles in various catalytic processes and offer sustainable solutions to current energy problems. Various synthetic methods for preparing different classes of CSNs, including the Stober method, solvothermal method, one-pot synthetic method involving surfactants, etc., are briefly mentioned here. The roles of various classes of CSNs are exemplified for both catalytic and electrocatalytic applications, including oxidation, reduction, coupling reactions, etc.
C1 [Gawande, Manoj B.; Goswami, Anandarup; Zboril, Radek] Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA.
[Guo, Huizhang; Peng, Dong-Liang] Xiamen Univ, Coll Mat, Dept Mat Sci & Engn, Xiamen 361005, Peoples R China.
[Biradar, Ankush V.] CSIR Natl Chem Lab, Catalysis Div, Pune 411008, Maharashtra, India.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Gawande, MB (reprint author), Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, Slechtitelu 11, Olomouc 78371, Czech Republic.
EM manoj.gawande@upol.cz; radek.zboril@upol.cz;
Varma.Rajender@epamail.epa.gov
RI Peng, DL/G-4096-2010; Zboril, Radek/F-5153-2015;
OI Zboril, Radek/0000-0002-3147-2196
FU Operational Program Education for Competitiveness - European Social Fund
of the Ministry of Education, Youth and Sports of the Czech Republic
[CZ.1.07/2.3.00/30.0041]; National Science Foundation in the USA
[1508611, 1134289]; [LO1305]
FX The authors gratefully acknowledge support from the project LO1305 and
the Operational Program Education for Competitiveness - European Social
Fund (project CZ.1.07/2.3.00/30.0041) of the Ministry of Education,
Youth and Sports of the Czech Republic. TA gratefully acknowledges
financial support from the National Science Foundation in the USA (Grant
Nos. 1508611 and 1134289) for his group's work on core-shell
nanocatalysis.
NR 460
TC 72
Z9 72
U1 88
U2 293
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 0306-0012
EI 1460-4744
J9 CHEM SOC REV
JI Chem. Soc. Rev.
PY 2015
VL 44
IS 21
BP 7540
EP 7590
DI 10.1039/c5cs00343a
PG 51
WC Chemistry, Multidisciplinary
SC Chemistry
GA CT9QX
UT WOS:000363152800005
PM 26288197
ER
PT B
AU Dutrow, E
AF Dutrow, Elizabeth
BE Rossiter, AP
Jones, BP
TI PROTECTING THE ENVIRONMENT AND INFLUENCING ENERGY PERFORMANCE WITHIN
PROCESS INDUSTRIES
SO ENERGY MANAGEMENT AND EFFICIENCY FOR THE PROCESS INDUSTRIES
LA English
DT Article; Book Chapter
C1 US EPA, ENERGY STAR Ind Sect Partnerships, Washington, DC 20460 USA.
RP Dutrow, E (reprint author), US EPA, ENERGY STAR Ind Sect Partnerships, Washington, DC 20460 USA.
NR 11
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-119-03322-6; 978-1-118-83825-9
PY 2015
BP 81
EP 92
D2 10.1002/9781119033226
PG 12
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA BD5OS
UT WOS:000361678300009
ER
PT J
AU Trisciuzzi, D
Alberga, D
Mansouri, K
Judson, R
Cellamare, S
Catto, M
Carotti, A
Benfenati, E
Novellino, E
Mangiatordi, GF
Nicolotti, O
AF Trisciuzzi, Daniela
Alberga, Domenico
Mansouri, Kamel
Judson, Richard
Cellamare, Saverio
Catto, Marco
Carotti, Angelo
Benfenati, Emilio
Novellino, Ettore
Mangiatordi, Giuseppe Felice
Nicolotti, Orazio
TI Docking-based classification models for exploratory toxicology studies
on high-quality estrogenic experimental data
SO FUTURE MEDICINAL CHEMISTRY
LA English
DT Article
ID ENDOCRINE-DISRUPTING CHEMICALS; LIGAND-BINDING DOMAIN; RECEPTOR-ALPHA;
COMPUTATIONAL TOXICOLOGY; DRUG DISCOVERY; BREAST-CANCER; QSAR; BETA;
TOOLS; RISK
AB Background: The ethical and practical limitation of animal testing has recently promoted computational methods for the fast screening of huge collections of chemicals. Results: The authors derived 24 reliable docking-based classification models able to predict the estrogenic potential of a large collection of chemicals provided by the US Environmental Protection Agency. Model performances were challenged by considering AUC, EF1% (EFmax = 7.1), -LR (at sensitivity = 0.75); +LR (at sensitivity = 0.25) and 37 reference compounds comprised within the training set. Moreover, external predictions were made successfully on ten representative known estrogenic chemicals and on a set consisting of >32,000 chemicals. Conclusion: The authors demonstrate that structure-based methods, widely applied to drug discovery programs, can be fairly adapted to exploratory toxicology studies.
C1 [Trisciuzzi, Daniela; Cellamare, Saverio; Catto, Marco; Carotti, Angelo; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio] Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70126 Bari, Italy.
[Alberga, Domenico] Univ Bari Aldo Moro, Dipartimento Interateneo Fis M Merlin, Ist Nazl Fis Nucl, I-70126 Bari, Italy.
[Mansouri, Kamel; Judson, Richard] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Benfenati, Emilio] IRCCS, Ist Ric Farmacol Mario Negri, I-20156 Milan, Italy.
[Novellino, Ettore] Univ Naples Federico II, Dipartimento Farm, I-80138 Naples, Italy.
RP Mangiatordi, GF (reprint author), Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70126 Bari, Italy.
EM giuseppe.mangiatordi@uniba.it; orazio.nicolotti@uniba.it
OI CATTO, Marco/0000-0002-8411-304X; Cellamare,
Saverio/0000-0003-3765-7842; Mansouri, Kamel/0000-0002-6426-8036
FU FIRB (Futuro in Ricerca) [RBFR12SJA8_003]; IDEA [GRBA11E-B3G]; LIFE+
project EDESIA
FX O Nicolotti and GF Mangiatordi wish to acknowledge FIRB (Futuro in
Ricerca 2012, RBFR12SJA8_003) and IDEA 2011 (GRBA11E-B3G). E Benfenati
would like to thank LIFE+ project EDESIA for funding. The authors have
no other relevant affiliations or financial involvement with any
organization or entity with a financial interest in or financial
conflict with the subject matter or materials discussed in the
manuscript apart from those disclosed.
NR 53
TC 3
Z9 3
U1 0
U2 3
PU FUTURE SCI LTD
PI LONDON
PA UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND
SN 1756-8919
EI 1756-8927
J9 FUTURE MED CHEM
JI Future Med. Chem.
PY 2015
VL 7
IS 14
BP 1921
EP 1936
DI 10.4155/fmc.15.103
PG 16
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CU1BB
UT WOS:000363252900011
PM 26440057
ER
PT B
AU Wilkin, RT
Lee, TR
McNeil, MS
Su, CM
Adair, C
AF Wilkin, Richard T.
Lee, Tony R.
McNeil, Mary Sue
Su, Chunming
Adair, Cherri
BE Naidu, R
Birke, V
TI Fourteen-Year Assessment of a Permeable Reactive Barrier for Treatment
of Hexavalent Chromium and Trichloroethylene
SO PERMEABLE REACTIVE BARRIER: SUSTAINABLE GROUNDWATER REMEDIATION
SE Advances in Trace Elements in the Environment
LA English
DT Article; Book Chapter
ID PERFORMANCE; IRON
C1 [Wilkin, Richard T.; McNeil, Mary Sue; Su, Chunming; Adair, Cherri] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
[Lee, Tony R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK USA.
RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-2448-1; 978-1-4822-2447-4
J9 ADV TRACE ELEM ENVIR
PY 2015
BP 99
EP 107
PG 9
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BD7FH
UT WOS:000362980800007
ER
PT B
AU Ludwig, RD
Wilkin, RT
Acree, SD
Ross, RR
Lee, TR
AF Ludwig, Ralph D.
Wilkin, Richard T.
Acree, Steven D.
Ross, Randall R.
Lee, Tony R.
BE Naidu, R
Birke, V
TI Organic-Based Permeable Reactive Barriers for the Treatment of Heavy
Metals, Arsenic, and Acidity
SO PERMEABLE REACTIVE BARRIER: SUSTAINABLE GROUNDWATER REMEDIATION
SE Advances in Trace Elements in the Environment
LA English
DT Article; Book Chapter
ID SLUG TEST
C1 [Ludwig, Ralph D.; Acree, Steven D.; Ross, Randall R.; Lee, Tony R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
[Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ada, OK USA.
RP Ludwig, RD (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
NR 8
TC 0
Z9 0
U1 1
U2 1
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-2448-1; 978-1-4822-2447-4
J9 ADV TRACE ELEM ENVIR
PY 2015
BP 135
EP 149
PG 15
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BD7FH
UT WOS:000362980800009
ER
PT J
AU Janssens-Maenhout, G
Crippa, M
Guizzardi, D
Dentener, F
Muntean, M
Pouliot, G
Keating, T
Zhang, Q
Kurokawa, J
Wankmuller, R
van der Gon, HD
Kuenen, JJP
Klimont, Z
Frost, G
Darras, S
Koffi, B
Li, M
AF Janssens-Maenhout, G.
Crippa, M.
Guizzardi, D.
Dentener, F.
Muntean, M.
Pouliot, G.
Keating, T.
Zhang, Q.
Kurokawa, J.
Wankmueller, R.
van der Gon, H. Denier
Kuenen, J. J. P.
Klimont, Z.
Frost, G.
Darras, S.
Koffi, B.
Li, M.
TI HTAP_v2.2: a mosaic of regional and global emission grid maps for 2008
and 2010 to study hemispheric transport of air pollution
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID TRENDS; METHODOLOGY; DIOXIDE; GASES; ASIA
AB The mandate of the Task Force Hemispheric Transport of Air Pollution (TF HTAP) under the Convention on Long-Range Transboundary Air Pollution (CLRTAP) is to improve the scientific understanding of the intercontinental air pollution transport, to quantify impacts on human health, vegetation and climate, to identify emission mitigation options across the regions of the Northern Hemisphere, and to guide future policies on these aspects.
The harmonization and improvement of regional emission inventories is imperative to obtain consolidated estimates on the formation of global-scale air pollution. An emissions data set has been constructed using regional emission grid maps (annual and monthly) for SO2, NOx, CO, NMVOC, NH3, PM10, PM2.5, BC and OC for the years 2008 and 2010, with the purpose of providing consistent information to global and regional scale modelling efforts.
This compilation of different regional gridded inventories - including that of the Environmental Protection Agency (EPA) for USA, the EPA and Environment Canada (for Canada), the European Monitoring and Evaluation Programme (EMEP) and Netherlands Organisation for Applied Scientific Research (TNO) for Europe, and the Model Intercomparison Study for Asia (MICS-Asia III) for China, India and other Asian countries - was gap-filled with the emission grid maps of the Emissions Database for Global Atmospheric Research (EDGARv4.3) for the rest of the world (mainly South America, Africa, Russia and Oceania). Emissions from seven main categories of human activities (power, industry, residential, agriculture, ground transport, aviation and shipping) were estimated and spatially distributed on a common grid of 0.1 degrees x 0.1 degrees longitude-latitude, to yield monthly, global, sector-specific grid maps for each substance and year.
The HTAP_v2.2 air pollutant grid maps are considered to combine latest available regional information within a complete global data set. The disaggregation by sectors, high spatial and temporal resolution and detailed information on the data sources and references used will provide the user the required transparency. Because HTAP_v2.2 contains primarily official and/or widely used regional emission grid maps, it can be recommended as a global baseline emission inventory, which is regionally accepted as a reference and from which different scenarios assessing emission reduction policies at a global scale could start.
An analysis of country-specific implied emission factors shows a large difference between industrialised countries and developing countries for acidifying gaseous air pollutant emissions (SO2 and NOx) from the energy and industry sectors. This is not observed for the particulate matter emissions (PM10, PM2.5), which show large differences between countries in the residential sector instead. The per capita emissions of all world countries, classified from low to high income, reveal an increase in level and in variation for gaseous acidifying pollutants, but not for aerosols. For aerosols, an opposite trend is apparent with higher per capita emissions of particulate matter for low income countries.
C1 [Janssens-Maenhout, G.; Crippa, M.; Guizzardi, D.; Dentener, F.; Muntean, M.; Koffi, B.] European Commiss, Joint Res Ctr, Inst Environm & Sustainabil, I-21027 Ispra, VA, Italy.
[Pouliot, G.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Keating, T.] US EPA, Off Air & Radiat, Washington, DC 20460 USA.
[Zhang, Q.; Li, M.] Tsinghua Univ, Ctr Earth Syst Sci, Minist Educ, Key Lab Earth Syst Modelling, Beijing 100084, Peoples R China.
[Kurokawa, J.] Asia Ctr Air Pollut Res, Nishi Ku, Niigata, Niigata 9502144, Japan.
[Wankmueller, R.] Fed Environm Agcy, EMEP, Ctr Emiss Inventory & Project, A-1090 Vienna, Austria.
[van der Gon, H. Denier; Kuenen, J. J. P.] TNO, Dept Climate Air & Sustainabil, NL-3584 CB Utrecht, Netherlands.
[Klimont, Z.] Int Inst Appl Syst Anal, A-2361 Laxenburg, Austria.
[Frost, G.] NOAA, Earth Syst Res Lab, Boulder, CO USA.
[Frost, G.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Darras, S.] Observ Midi Pyrenees, CNRS, SEDOO, F-31400 Toulouse, France.
[Li, M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Janssens-Maenhout, G.] Univ Ghent, B-9000 Ghent, Belgium.
RP Janssens-Maenhout, G (reprint author), European Commiss, Joint Res Ctr, Inst Environm & Sustainabil, Via Fermi 2749, I-21027 Ispra, VA, Italy.
EM greet.maenhout@jrc.ec.europa.eu
RI Klimont, Zbigniew/P-7641-2015; Zhang, Qiang/D-9034-2012; Frost,
Gregory/I-1958-2013; Manager, CSD Publications/B-2789-2015
OI Klimont, Zbigniew/0000-0003-2630-198X;
FU EC-DG Environment [AA 070402/2007/47597/ MAR/C5, 33075]
FX This research was partially funded by EC-DG Environment under AA
070402/2007/47597/ MAR/C5 and 33075. S. Galmarini (JRC) and A. Zuber (DG
Environment) are thanked for the continuing support to the HTAP project.
The authors would also like to thank all HTAP-modelers providing first
feedback. Colleagues of the ECCAD project, C. Granier, A. Mieville, of
the TNO-MACC project and of EMEP-MSCW are gratefully acknowledged for
help provided during the preparation of this work.
NR 65
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PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 19
BP 11411
EP 11432
DI 10.5194/acp-15-11411-2015
PG 22
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CT7CN
UT WOS:000362971000030
ER
PT J
AU Reichle, LJ
Cook, R
Yanca, CA
Sonntag, DB
AF Reichle, Lawrence J.
Cook, Rich
Yanca, Catherine A.
Sonntag, Darrell B.
TI Development of organic gas exhaust speciation profiles for nonroad
spark-ignition and compression-ignition engines and equipment
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID EMISSIONS; BLENDS
AB The composition of exhaust emissions from nonroad engines and equipment varies based on a number of parameters, including engine type, emission control technology, fuel composition, and operating conditions. Speciated emissions data which characterize the chemical composition of these emissions are needed to develop chemical speciation profiles used for air quality modeling and to develop air toxics inventories. In this paper, we present results of an extensive review and analysis of available exhaust speciation data for total organic gases (TOG) for spark ignition (SI) engines running on gasoline/ethanol blends now in widespread use, and compression ignition (CI) engines running on diesel fuel. We identified two data sets best suited for development of exhaust speciation profiles. Neither of these data sets have previously been published. We analyzed the resulting speciation profiles for differences in SI engine exhaust composition between 2-stroke and 4-stroke engines using E0 (0% ethanol) and E10 (10% ethanol) blends, and differences in CI engine exhaust composition among engines meeting different emission standards. Exhaust speciation profiles were also analyzed to compare differences in maximum incremental reactivity (MIR) values; this is a useful indicator for evaluating how organic gases may affect ozone formation for air quality modeling. Our analyses found significant differences in speciated emissions from 2-stroke and 4-stroke SI engines, and between engines running on E0 and E10 fuels. We found significant differences in profiles from pre-Tier 1 CI engines, engines meeting Tier 1 standards, and engines meeting Tier 2 standards. Although data for nonroad CI engines meeting tier 4 standards with control devices such as particulate filters and selective catalyst reduction (SCR) devices were not available, data from highway CI engines suggest these technologies will substantially change profiles for nonroad CI engines as well (EPA, 2014c).Implications: The nonroad engine data sets analyzed in this study will substantially improve exhaust speciation profiles used to characterize organic gas emissions from nonroad engines. Since nonroad engines are major contributors to ambient air pollution, these profiles can considerably improve U.S. emission inventories for gaseous air toxics emitted from nonroad engines. The speciation profiles developed in this paper can be used to develop more accurate emission inputs to chemical transport models, leading to more accurate air quality modeling.
C1 [Cook, Rich; Yanca, Catherine A.; Sonntag, Darrell B.] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA.
RP Cook, R (reprint author), US EPA, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA.
EM cook.rich@epa.gov
FU EPA; Department of Energy
FX This work was supported in part by an appointment to the ORISE
participant research program support by an interagency agreement between
EPA and the Department of Energy. This paper may not necessarily reflect
the views of EPA and no official endorsement should be inferred.
NR 26
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Z9 0
U1 3
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 10
BP 1185
EP 1193
DI 10.1080/10962247.2015.1020118
PG 9
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CT3QK
UT WOS:000362721600003
PM 26452015
ER
PT J
AU Lu, Z
Streets, DG
de Foy, B
Lamsal, LN
Duncan, BN
Xing, J
AF Lu, Z.
Streets, D. G.
de Foy, B.
Lamsal, L. N.
Duncan, B. N.
Xing, J.
TI Emissions of nitrogen oxides from US urban areas: estimation from Ozone
Monitoring Instrument retrievals for 2005-2014
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID GOME-SATELLITE-OBSERVATIONS; OMI TROPOSPHERIC NO2; POWER-PLANT PLUMES;
UNITED-STATES; AIR-QUALITY; SPACE; LIFETIMES; TRENDS; SO2; COLUMNS
AB Satellite remote sensing of tropospheric nitrogen dioxide (NO2) can provide valuable information for estimating surface nitrogen oxides (NOx) emissions. Using an exponentially modified Gaussian (EMG) method and taking into account the effect of wind on observed NO2 distributions, we estimate 3-year moving-average emissions of summertime NOx from 35 US (United States) urban areas directly from NO2 retrievals of the Ozone Monitoring Instrument (OMI) during 2005-2014. Following conclusions of previous studies that the EMG method provides robust and accurate emission estimates under strong-wind conditions, we derive top-down NOx emissions from each urban area by applying the EMG method to OMI data with wind speeds greater than 3-5 m s(-1). Meanwhile, we find that OMI NO2 observations under weak-wind conditions (i.e., < 3 m s(-1)) are qualitatively better correlated to the surface NOx source strength in comparison to all-wind OMI maps; therefore, we use them to calculate the satellite-observed NO2 burdens of urban areas and compare with NOx emission estimates. The EMG results show that OMI-derived NOx emissions are highly correlated (R > 0.93) with weak-wind OMI NO2 burdens as well as with bottom-up NOx emission estimates over 35 urban areas, implying a linear response of the OMI observations to surface emissions under weak-wind conditions. The simultaneous EMG-obtained effective NO2 lifetimes (similar to 3.5 +/- 1.3 h), however, are biased low in comparison to the summertime NO2 chemical lifetimes. In general, isolated urban areas with NOx emission intensities greater than similar to 2 Mg h(-1) produce statistically significant weak-wind signals in 3-year average OMI data. From 2005 to 2014, we estimate that total OMI-derived NOx emissions over all selected US urban areas decreased by 49 %, consistent with reductions of 43, 47, 49, and 44 % in the total bottom-up NOx emissions, the sum of weak-wind OMI NO2 columns, the total weak-wind OMI NO2 burdens, and the averaged NO2 concentrations, respectively, reflecting the success of NOx control programs for both mobile sources and power plants. The decrease rates of these NOx-related quantities are found to be faster (i.e., -6.8 to -9.3 % yr(-1)) before 2010 and slower (i.e., -3.4 to -4.9 % yr(-1)) after 2010. For individual urban areas, we calculate the R values of pair-wise trends among the OMI-derived and bottom-up NOx emissions, the weak-wind OMI NO2 burdens, and ground-based NO2 measurements, and high correlations are found for all urban areas (median R= 0.8), particularly large ones (R up to 0.97). The results of the current work indicate that using the EMG method and considering the wind effect, the OMI data allow for the estimation of NOx emissions from urban areas and the direct constraint of emission trends with reasonable accuracy.
C1 [Lu, Z.; Streets, D. G.] Argonne Natl Lab, Div Energy Syst, Argonne, IL 60439 USA.
[de Foy, B.] St Louis Univ, Dept Earth & Atmospher Sci, St Louis, MO 63108 USA.
[Lamsal, L. N.] Univ Space Res Assoc, Goddard Earth Sci Technol & Res, Columbia, MD 21046 USA.
[Lamsal, L. N.; Duncan, B. N.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Xing, J.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Lu, Z (reprint author), Argonne Natl Lab, Div Energy Syst, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM zlu@anl.gov
RI de Foy, Benjamin/A-9902-2010; Duncan, Bryan/A-5962-2011
OI de Foy, Benjamin/0000-0003-4150-9922;
FU National Aeronautics and Space Administration (NASA) as a part of the
Air Quality Applied Sciences Team (AQAST) program; Argonne National
Laboratory is operated by UChicago Argonne, LLC [DE-AC02-06CH11357]
FX This work was sponsored by the National Aeronautics and Space
Administration (NASA) as a part of the Air Quality Applied Sciences Team
(AQAST) program, for which we are grateful to the NASA project officer
John Haynes and the AQAST team leader Daniel Jacob. We acknowledge the
free use of tropospheric NO2 column data from the OMI sensor
available at www.temis.nl. The Argonne National Laboratory is operated
by UChicago Argonne, LLC, under contract no. DE-AC02-06CH11357 with the
US Department of Energy.
NR 61
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Z9 14
U1 5
U2 31
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 18
BP 10367
EP 10383
DI 10.5194/acp-15-10367-2015
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CT0AZ
UT WOS:000362457400009
ER
PT J
AU Teichman, KY
Persily, AK
Emmerich, SJ
AF Teichman, Kevin Y.
Persily, Andrew K.
Emmerich, Steven J.
TI Indoor air quality in high-performing building case studies: Got data?
SO SCIENCE AND TECHNOLOGY FOR THE BUILT ENVIRONMENT
LA English
DT Article
ID ENVIRONMENTS
AB This article is a review of how indoor air quality has been addressed in case studies of high-performing buildings, specifically the case studies described in ASHRAE's High Performing Buildings magazine. Nearly all of the reported case studies address energy performance, both in the design and operation of the building. In contrast, while most case studies mention indoor air quality design considerations, they generally do not address indoor air quality in a comprehensive manner, nor do they present the impacts of indoor air quality-related and other design considerations on indoor concentrations or on the health, comfort, and productivity of building occupants. Based upon this analysis, as well as existing standards and guidelines, a discussion is provided about what indoor air quality information should be collected during the early stages of a building's operation to demonstrate its indoor air quality performance. This information includes (a) documentation of key indoor air quality-related design features and their implementation during building construction, commissioning, and initial operation; (b) collection of indoor air quality performance data, including measured pollutant concentrations and ventilation rates; and (c) assessment of occupant satisfaction using occupant surveys. To facilitate comparisons of indoor air quality performance among buildings, suggestions are provided on how to collect and report this information in a consistent manner.
C1 [Teichman, Kevin Y.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Persily, Andrew K.; Emmerich, Steven J.] NIST, Gaithersburg, MD 20899 USA.
RP Teichman, KY (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave,NW 8101R, Washington, DC 20460 USA.
EM teichman.kevin@epa.gov
NR 28
TC 1
Z9 1
U1 2
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2374-4731
EI 2374-474X
J9 SCI TECHNOL BUILT EN
JI Sci. Technol. Built Environ.
PY 2015
VL 21
IS 1
SI SI
BP 91
EP 98
DI 10.1080/10789669.2014.976509
PG 8
WC Thermodynamics; Construction & Building Technology; Engineering,
Mechanical
SC Thermodynamics; Construction & Building Technology; Engineering
GA CS4SW
UT WOS:000362067200010
ER
PT J
AU Xing, J
Mathur, R
Pleim, J
Hogrefe, C
Gan, CM
Wong, DC
Wei, C
AF Xing, J.
Mathur, R.
Pleim, J.
Hogrefe, C.
Gan, C. -M.
Wong, D. C.
Wei, C.
TI Can a coupled meteorology-chemistry model reproduce the historical trend
in aerosol direct radiative effects over the Northern Hemisphere?
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID ENERGY SYSTEM CERES; OPTICAL DEPTH; AIR-POLLUTION; IMAGING
SPECTRORADIOMETER; SATELLITE-OBSERVATIONS; ATMOSPHERE RADIATION;
SOLAR-RADIATION; ORGANIC AEROSOL; SOUTHEAST-ASIA; EARTHS SURFACE
AB The ability of a coupled meteorology-chemistry model, i.e., Weather Research and Forecast and Community Multiscale Air Quality (WRF-CMAQ), to reproduce the historical trend in aerosol optical depth (AOD) and clear-sky shortwave radiation (SWR) over the Northern Hemisphere has been evaluated through a comparison of 21-year simulated results with observation-derived records from 1990 to 2010. Six satellite-retrieved AOD products including AVHRR, TOMS, SeaWiFS, MISR, MODIS-Terra and MODIS-Aqua as well as long-term historical records from 11 AERONET sites were used for the comparison of AOD trends. Clear-sky SWR products derived by CERES at both the top of atmosphere (TOA) and surface as well as surface SWR data derived from seven SURFRAD sites were used for the comparison of trends in SWR. The model successfully captured increasing AOD trends along with the corresponding increased TOA SWR (upwelling) and decreased surface SWR (downwelling) in both eastern China and the northern Pacific. The model also captured declining AOD trends along with the corresponding decreased TOA SWR (upwelling) and increased surface SWR (downwelling) in the eastern US, Europe and the northern Atlantic for the period of 2000-2010. However, the model underestimated the AOD over regions with substantial natural dust aerosol contributions, such as the Sahara Desert, Arabian Desert, central Atlantic and northern Indian Ocean. Estimates of the aerosol direct radiative effect (DRE) at TOA are comparable with those derived by measurements. Compared to global climate models (GCMs), the model exhibits better estimates of surface-aerosol direct radiative efficiency (E-tau). However, surface-DRE tends to be underestimated due to the underestimated AOD in land and dust regions. Further investigation of TOA-E-tau estimations as well as the dust module used for estimates of windblown-dust emissions is needed.
C1 [Xing, J.; Mathur, R.; Pleim, J.; Hogrefe, C.; Gan, C. -M.; Wong, D. C.; Wei, C.] US EPA, Durham, NC 27711 USA.
[Wei, C.] Max Planck Inst Chem, Multiphase Chem Dept, D-55128 Mainz, Germany.
RP Xing, J (reprint author), US EPA, Res Triangle Pk, Durham, NC 27711 USA.
EM xing.jia@epa.gov
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU Department of Energy project (IA) [DE-SC000378]; EPA (IA) [RW-89-9233260
1]; National Research Council Research Associateship Award at the US EPA
FX This work was supported in part by an inter-agency agreement between the
Department of Energy project (IA number is DE-SC000378) and the EPA (IA
number is RW-89-9233260 1). This research was performed while Jia Xing
and Chuen-Meei Gan held a National Research Council Research
Associateship Award at the US EPA. The authors gratefully acknowledge
the availability of AVHRR, TOMS, SeaWiFS, MISR, MODIS-Terra and
MODIS-Aqua, CERES, AERONET, and SURFRAD data.
NR 77
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U1 3
U2 11
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 17
BP 9997
EP 10018
DI 10.5194/acp-15-9997-2015
PG 22
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CR7YH
UT WOS:000361567600016
ER
PT B
AU El-Masri, H
McLanahan, E
Martin, S
AF El-Masri, Hisham
McLanahan, Eva
Martin, Sheppard
BE AbouDonia, MB
TI Principles of Toxicokinetics and Predictive Toxicokinetics Modeling
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID DERMAL ABSORPTION; PHARMACOKINETIC MODEL; PBPK MODEL;
PERCUTANEOUS-ABSORPTION; BREATH CONCENTRATIONS; INHALATION EXPOSURE;
HUMANS; RATS; CHLOROFORM; OCTAMETHYLCYCLOTETRASILOXANE
C1 [El-Masri, Hisham] US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[McLanahan, Eva] US PHS, Div Community Hlth Invest, Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
[Martin, Sheppard] Procter & Gamble Co, Cent Prod Safety, Cincinnati, OH USA.
RP El-Masri, H (reprint author), US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
NR 28
TC 0
Z9 0
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 85
EP 99
PG 15
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100006
ER
PT B
AU Louis, G
Stoker, T
AF Louis, Gwendolyn
Stoker, Tammy
BE AbouDonia, MB
TI Endocrine Disruptors
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID ARYL-HYDROCARBON RECEPTOR; BROMINATED FLAME RETARDANTS; BREAST-CANCER
CELLS; CONSTITUTIVE ANDROSTANE RECEPTOR; ADRENOCORTICAL CARCINOMA-CELLS;
SPRAGUE-DAWLEY RATS; EXPOSED IN-UTERO; GENE-EXPRESSION; FEMALE RAT;
REPRODUCTIVE DEVELOPMENT
C1 [Louis, Gwendolyn; Stoker, Tammy] US EPA, Endocrine Toxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27709 USA.
RP Louis, G (reprint author), US EPA, Endocrine Toxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27709 USA.
NR 134
TC 1
Z9 1
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 289
EP 308
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100015
ER
PT B
AU Luebke, RW
AF Luebke, Robert W.
BE AbouDonia, MB
TI Immune System Toxicity and Immunotoxicity Hazard Identification
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID FOOD ALLERGY; INFLUENZA INFECTION; AUTOIMMUNE-DISEASES;
ANTIBODY-RESPONSE; CHRONIC STRESS; SEX-HORMONES; EXPOSED MICE; LEAD;
SUSCEPTIBILITY; INFLAMMATION
C1 US EPA, Cardiovasc & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
RP Luebke, RW (reprint author), US EPA, Cardiovasc & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
NR 51
TC 0
Z9 0
U1 1
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 323
EP 339
PG 17
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100017
ER
PT B
AU Klinefelter, GR
AF Klinefelter, Gary R.
BE AbouDonia, MB
TI Male Reproductive Toxicology: Environmental Exposures versus
Reproductive Competence
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID ENDOCRINE DISRUPTION; SPERM; RAT; FERTILITY; TESTIS; ANTIANDROGENS;
PHTHALATE; ANIMALS; SEMEN; SP22
C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Durham, NC 27708 USA.
RP Klinefelter, GR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Durham, NC 27708 USA.
NR 35
TC 0
Z9 0
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 472
EP 491
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100022
ER
PT B
AU Goldman, JM
Cooper, RL
AF Goldman, Jerome M.
Cooper, Ralph L.
BE AbouDonia, MB
TI Female Reproductive Toxicology
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID LUTEINIZING-HORMONE SURGE; MENSTRUAL-CYCLE CHARACTERISTICS;
SPRAGUE-DAWLEY RATS; SEXUAL-DIFFERENTIATION; ESTROUS-CYCLE; MAMMALIAN
OVA; BISPHENOL-A; IN-UTERO; HYPOTHALAMIC CATECHOLAMINES;
POLYCHLORINATED-BIPHENYLS
C1 [Goldman, Jerome M.; Cooper, Ralph L.] US EPA, Endocrine Toxicol Branch, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27708 USA.
RP Goldman, JM (reprint author), US EPA, Endocrine Toxicol Branch, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27708 USA.
NR 142
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 493
EP 517
PG 25
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100023
ER
PT B
AU Farraj, AK
Hazari, MS
Costa, DL
AF Farraj, Aimen K.
Hazari, Mehdi S.
Costa, Daniel L.
BE AbouDonia, MB
TI Pulmonary Toxicology
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID GENETIC SUSCEPTIBILITY; TRIMELLITIC ANHYDRIDE; AIR-POLLUTION; TOXICITY;
LUNG; MECHANISMS; EXPOSURE; ASBESTOS; ASTHMA; PNEUMOCONIOSIS
C1 [Farraj, Aimen K.; Hazari, Mehdi S.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Durham, NC 27708 USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Farraj, AK (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Durham, NC 27708 USA.
NR 73
TC 0
Z9 0
U1 1
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 519
EP 538
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100024
ER
PT J
AU Spassova, MA
Miller, DJ
Nikolov, AS
AF Spassova, Maria A.
Miller, David J.
Nikolov, Alexander S.
TI Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging
and DNA Repair Processes in Shaping the Dose-Response Curve of
KBrO3-Induced DNA Damage
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CONTINUOUS END-POINTS; POTASSIUM BROMATE; OXIDATIVE STRESS;
RISK-ASSESSMENT; CELL-PROLIFERATION; GENETIC TOXICOLOGY; IWGT REPORT;
CARCINOGENICITY; MUTAGENICITY; KIDNEYS
AB We have developed a kinetic model to investigate how DNA repair processes and scavengers of reactive oxygen species (ROS) can affect the dose-response shape of prooxidant induced DNA damage. We used as an example chemical KBrO3 which is activated by glutathione and forms reactive intermediates that directly interact with DNA to form 8-hydroxy-2-deoxyguanosine DNA adducts (8-OH-dG). The single strand breaks (SSB) that can result from failed base excision repair of these adducts were considered as an effect downstream from 8-OH-dG. We previously demonstrated that, in the presence of effective base excision repair, 8-OH-dG can exhibit threshold-like dose-response dependence, while the downstream SSB can still exhibit a linear dose-response. Here we demonstrate that this result holds for a variety of conditions, including low levels of GSH, the presence of additional SSB repair mechanisms, or a scavenger. It has been shown that melatonin, a terminal scavenger, inhibits KBrO3-caused oxidative damage. Our modeling revealed that sustained exposure to KBrO3 can lead to fast scavenger exhaustion, in which case the dose-response shapes for both endpoints are not substantially affected. The results are important to consider when forming conclusions on a chemical's toxicity dose dependence based on the dose-response of early genotoxic events.
C1 [Spassova, Maria A.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Miller, David J.] NCI, Div Canc Biol, NIH, Rockville, MD 20892 USA.
[Nikolov, Alexander S.] Langley High Sch, Mclean, VA 22101 USA.
RP Spassova, MA (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
EM spassova.maria@epa.gov
NR 36
TC 3
Z9 3
U1 0
U2 2
PU HINDAWI PUBLISHING CORP
PI NEW YORK
PA 315 MADISON AVE 3RD FLR, STE 3070, NEW YORK, NY 10017 USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
AR 764375
DI 10.1155/2015/764375
PG 12
WC Cell Biology
SC Cell Biology
GA CR9HB
UT WOS:000361664000001
ER
PT J
AU Williams, WC
Lehmann, JR
Boykin, E
Selgrade, MK
Lehmann, DM
AF Williams, W. C.
Lehmann, J. R.
Boykin, E.
Selgrade, M. K.
Lehmann, D. M.
TI Lung function changes in mice sensitized to ammonium hexachloroplatinate
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Ammonium hexachloroplatinate; occupational asthma; platinum; pulmonary
hyperresponsiveness; respiratory hypersensitivity; whole-body
plethysmography
ID TRIMELLITIC ANHYDRIDE POWDER; PLATINUM REFINERY WORKERS; ONLY INHALATION
EXPOSURE; TOLUENE DIISOCYANATE TDI; ALLERGIC AIRWAYS DISEASE; GROUP
METAL-SALTS; DERMAL SENSITIZATION; OCCUPATIONAL ASTHMA;
ANTIBODY-PRODUCTION; COMPLEX SALTS
AB Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary responses to platinum, we developed a mouse model of platinum hypersensitivity. Mice were sensitized through application of ammonium hexachloroplatinate (AHCP) to the shaved back on days 0, 5 and 19, and to each ear on days 10, 11 and 12. On days 24 and 29, mice were challenged by oropharyngeal aspiration with AHCP in saline. Before and immediately after challenge, pulmonary responses were assessed using whole body plethysmography (WBP). A dose-dependent increase in immediate responses was observed in AHCP-sensitized and challenged mice. On days 26 and 31, changes in ventilatory responses to methacholine (Mch) aerosol were assessed by WBP; dose-dependent increases in Mch responsiveness occurred in sensitized mice. Lymph node cell counts indicate a proliferative response in lymph nodes draining the sites of application. Bronchoalveolar lavage fluid harvested from sensitized mice contained an average of 5% eosinophils compared to less than 0.5% in non-sensitized mice (p<0.05); significant increases in total serum immunoglobulin E were observed for all sensitized mice. Although a second airway challenge on day 29 affected some results, only one airway challenge was needed to observe changes in lung function.
C1 [Williams, W. C.; Lehmann, J. R.; Boykin, E.; Lehmann, D. M.] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Lab NHEERL, Res Triangle Pk, NC 27711 USA.
[Selgrade, M. K.] ICF Int, Fairfax, VA USA.
RP Lehmann, DM (reprint author), US EPA, EPHD Cardiopulm & Immunotoxicol Branch, NHEERL, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lehmann.david@epa.gov
NR 87
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PY 2015
VL 27
IS 10
BP 468
EP 480
DI 10.3109/08958378.2015.1070219
PG 13
WC Toxicology
SC Toxicology
GA CR4TN
UT WOS:000361332100003
PM 26309092
ER
PT J
AU Budisulistiorini, SH
Li, X
Bairai, ST
Renfro, J
Liu, Y
Liu, YJ
McKinney, KA
Martin, ST
McNeill, VF
Pye, HOT
Nenes, A
Neff, ME
Stone, EA
Mueller, S
Knote, C
Shaw, SL
Zhang, Z
Gold, A
Surratt, JD
AF Budisulistiorini, S. H.
Li, X.
Bairai, S. T.
Renfro, J.
Liu, Y.
Liu, Y. J.
McKinney, K. A.
Martin, S. T.
McNeill, V. F.
Pye, H. O. T.
Nenes, A.
Neff, M. E.
Stone, E. A.
Mueller, S.
Knote, C.
Shaw, S. L.
Zhang, Z.
Gold, A.
Surratt, J. D.
TI Examining the effects of anthropogenic emissions on isoprene-derived
secondary organic aerosol formation during the 2013 Southern Oxidant and
Aerosol Study (SOAS) at the Look Rock, Tennessee ground site
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID POSITIVE MATRIX FACTORIZATION; IONIZATION MASS-SPECTROMETRY; CHEMICAL
SPECIATION MONITOR; SOUTHEASTERN UNITED-STATES; FINE-PARTICLE WATER;
REACTIVE UPTAKE; ATMOSPHERIC AEROSOLS; AMBIENT AEROSOL; ORGANOSULFATE
FORMATION; 2-METHYLGLYCERIC ACID
AB A suite of offline and real-time gas-and particlephase measurements was deployed at Look Rock, Tennessee (TN), during the 2013 Southern Oxidant and Aerosol Study (SOAS) to examine the effects of anthropogenic emissions on isoprene-derived secondary organic aerosol (SOA) formation. High-and low-time-resolution PM2.5 samples were collected for analysis of known tracer compounds in isoprene-derived SOA by gas chromatography/electron ionizationmass spectrometry (GC/EI-MS) and ultra performance liquid chromatography/diode array detection-electrospray ionization-high-resolution quadrupole time-of-flight mass spectrometry (UPLC/DAD-ESI-HR-QTOFMS). Source apportionment of the organic aerosol (OA) was determined by positive matrix factorization (PMF) analysis of mass spectro-metric data acquired on an Aerodyne Aerosol Chemical Speciation Monitor (ACSM). Campaign average mass concentrations of the sum of quantified isoprene-derived SOA tracers contributed to similar to 9% (up to 28 %) of the total OA mass, with isoprene-epoxydiol (IEPOX) chemistry accounting for similar to 97% of the quantified tracers. PMF analysis resolved a factor with a profile similar to the IEPOX-OA factor resolved in an Atlanta study and was therefore designated IEPOX-OA. This factor was strongly correlated (r(2) > 0.7) with 2-methyltetrols, C5-alkene triols, IEPOX-derived organosulfates, and dimers of organosulfates, confirming the role of IEPOX chemistry as the source. On average, IEPOX-derived SOA tracer mass was similar to 26% (up to 49 %) of the IEPOX-OA factor mass, which accounted for 32% of the total OA. A low-volatility oxygenated organic aerosol (LV-OOA) and an oxidized factor with a profile similar to 91Fac observed in areas where emissions are biogenic-dominated were also resolved by PMF analysis, whereas no primary organic aerosol (POA) sources could be resolved. These findings were consistent with low levels of primary pollutants, such as nitric oxide (NO similar to 0.03 ppb), carbon monoxide (CO similar to 116 ppb), and black carbon (BC similar to 0.2 mu g m(-3)). Particle-phase sulfate is fairly correlated (r(2) similar to 0.3) with both methacrylic acid epoxide (MAE)/hydroxymethyl-methyl-ff lactone (HMML)-(henceforth called methacrolein (MACR)derived SOA tracers) and IEPOX-derived SOA tracers, and more strongly correlated (r(2) similar to 0.6) with the IEPOX-OA factor, in sum suggesting an important role of sulfate in isoprene SOA formation. Moderate correlation between the MACR-derived SOA tracer 2-methylglyceric acid with sum of reactive and reservoir nitrogen oxides (NOy; r(2) = 0.38) and nitrate (r(2) = 0.45) indicates the potential influence of anthropogenic emissions through long-range transport. Despite the lack of a clear association of IEPOX-OA with locally estimated aerosol acidity and liquid water content (LWC), box model calculations of IEPOX uptake using the simpleGAMMA model, accounting for the role of acidity and aerosol water, predicted the abundance of the IEPOX-derived SOA tracers 2-methyltetrols and the corresponding sulfates with good accuracy (r(2) similar to 0.5 and similar to 0.7, respectively). The modeling and data combined suggest an anthropogenic influence on isoprene-derived SOA formation through acid-catalyzed heterogeneous chemistry of IEPOX in the southeastern US. However, it appears that this process was not limited by aerosol acidity or LWC at Look Rock during SOAS.
Future studies should further explore the extent to which acidity and LWC as well as aerosol viscosity and morphology becomes a limiting factor of IEPOX-derived SOA, and their modulation by anthropogenic emissions.
C1 [Budisulistiorini, S. H.; Li, X.; Zhang, Z.; Gold, A.; Surratt, J. D.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
[Bairai, S. T.; Mueller, S.] Tennessee Valley Author, Muscle Shoals, AL 35660 USA.
[Renfro, J.] Natl Pk Serv, Gatlinburg, TN USA.
[Liu, Y.; Liu, Y. J.; McKinney, K. A.; Martin, S. T.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[McNeill, V. F.] Columbia Univ, Dept Chem Engn, New York, NY USA.
[Budisulistiorini, S. H.; Pye, H. O. T.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Nenes, A.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Nenes, A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Nenes, A.] Hellas, Fdn Res & Technol, ICE HT, Patras, Greece.
[Neff, M. E.; Stone, E. A.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA.
[Knote, C.] Univ Munich, Dept Expt Meteorol, Munich, Germany.
[Shaw, S. L.] Elect Power Res Inst, Palo Alto, CA USA.
RP Surratt, JD (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
EM surratt@unc.edu
RI Martin, Scot/G-1094-2015; Knote, Christoph/A-9809-2010; Surratt,
Jason/D-3611-2009; Pye, Havala/F-5392-2012
OI Martin, Scot/0000-0002-8996-7554; Knote, Christoph/0000-0001-9105-9179;
Surratt, Jason/0000-0002-6833-1450; Pye, Havala/0000-0002-2014-2140
FU US Environmental Protection Agency (EPA) [835404]; Electric Power
Research Institute (EPRI); National Oceanic and Atmospheric
Administration (NOAA) Climate Program Office [NA13OAR4310064]; Fulbright
Presidential Fellowship; UNC Graduate School Off-Campus Dissertation
Research Fellowship; US EPA Science to Achieve Results (STAR) program
[835401]
FX This work was funded by the US Environmental Protection Agency (EPA)
through grant number 835404. The contents of this publication are solely
the responsibility of the authors and do not necessarily represent the
official views of the US EPA. Further, the US EPA does not endorse the
purchase of any commercial products or services mentioned in the
publication. The US EPA through its Office of Research and Development
collaborated in the research described here. It has been subjected to
Agency review and approved for publication, but may not necessarily
reflect official Agency policy. The author would also like to thank the
Electric Power Research Institute (EPRI) for their support. This study
was supported in part by the National Oceanic and Atmospheric
Administration (NOAA) Climate Program Office's AC4 program, award #
NA13OAR4310064. We thank Bill Hicks of the Tennessee Valley Authority
(TVA) for his assistance in collecting the collocated monitoring data at
the LRK site. S. H. Budisulistiorini was supported by a Fulbright
Presidential Fellowship (2010-2013) for attending the University of
North Carolina at Chapel Hill and the UNC Graduate School Off-Campus
Dissertation Research Fellowship, as well as partial appointment to the
Internship/Research Participation Program at the Office of Research and
Development, US EPA, administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the US Department
of Energy and EPA. M. Neff and E. A. Stone were supported by US EPA
Science to Achieve Results (STAR) program grant number 835401. The
authors thank Lynn Russell, Timothy Bertram and Christopher Cappa as
well as their respective groups for their collaboration during the SOAS
campaign at LRK. The authors thank Louisa Emmons for her assistance with
forecasts made available during the SOAS campaign. The authors thank
John Offenberg for providing access to a Sunset Laboratory OC/EC
analysis instrument. The authors also thank Tianqu Cui for his
assistance in helping deploy instrumentation from the UNC group, and
Wendy Marth and Theran Riedel for their assistance in helping calibrate
the acetate CIMS. We would like to thank Annmarie Carlton, Joost deGouw,
Jose Jimenez, and Allen Goldstein for helping to organize the SOAS
campaign and coordinating communication between ground sites.
NR 86
TC 32
Z9 32
U1 23
U2 82
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 15
BP 8871
EP 8888
DI 10.5194/acp-15-8871-2015
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CP5UI
UT WOS:000359949700019
ER
PT J
AU Yahya, K
Wang, K
Zhang, Y
Kleindienst, TE
AF Yahya, K.
Wang, K.
Zhang, Y.
Kleindienst, T. E.
TI Application of WRF/Chem over North America under the AQMEII Phase 2-Part
2: Evaluation of 2010 application and responses of air quality and
meteorology-chemistry interactions to changes in emissions and
meteorology from 2006 to 2010
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; EXTREME HEAT EVENTS; UNITED-STATES;
CLIMATE-CHANGE; REGIONAL CLIMATE; US; IMPACTS; OZONE; PARAMETERIZATION;
MODELS
AB The Weather Research and Forecasting model with Chemistry (WRF/Chem) simulation with the 2005 Carbon Bond (CB05) gas-phase mechanism coupled to the Modal for Aerosol Dynamics for Europe (MADE) and the volatility basis set approach for secondary organic aerosol (SOA) are conducted over a domain in North America for 2006 and 2010 as part of the Air Quality Model Evaluation International Initiative (AQMEII) Phase 2 project. Following the Part 1 paper that focuses on the evaluation of the 2006 simulations, this Part 2 paper focuses on a comparison of model performance in 2006 and 2010 as well as analysis of the responses of air quality and meteorology-chemistry interactions to changes in emissions and meteorology from 2006 to 2010. In general, emissions for gaseous and aerosol species decrease from 2006 to 2010, leading to a reduction in gaseous and aerosol concentrations and associated changes in radiation and cloud variables due to various feedback mechanisms. WRF/Chem is able to reproduce most observations and the observed variation trends from 2006 to 2010, despite its slightly worse performance than WRF that is likely due to inaccurate chemistry feedbacks resulting from less accurate emissions and chemical boundary conditions (BCONs) in 2010. Compared to 2006, the performance for most meteorological variables in 2010 gives lower normalized mean biases but higher normalized mean errors and lower correlation coefficients. The model also shows poorer performance for most chemical variables in 2010. This could be attributed to underestimations in emissions of some species, such as primary organic aerosol in some areas of the US in 2010, and inaccurate chemical BCONs and meteorological predictions. The inclusion of chemical feedbacks in WRF/Chem reduces biases in meteorological predictions in 2010; however, it increases errors and weakens correlations comparing to WRF simulations. Sensitivity simulations show that the net changes in meteorological variables from 2006 to 2010 are mostly influenced by changes in meteorology and those of ozone and fine particulate matter are influenced to a large extent by emissions and/or chemical BCONs and to a lesser extent by changes in meteorology. Using a different set of emissions and/or chemical BCONs helps improve the performance of individual variables, although it does not improve the degree of agreement with observed interannual trends. These results indicate a need to further improve the accuracy and consistency of emissions and chemical BCONs, the representations of SOA and chemistry-meteorology feedbacks in the online-coupled models.
C1 [Yahya, K.; Wang, K.; Zhang, Y.] NCSU, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Kleindienst, T. E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Zhang, Y (reprint author), NCSU, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
EM yzhang9@ncsu.edu
RI Wang, Kai/D-4262-2013
OI Wang, Kai/0000-0002-2375-5989
FU National Science Foundation [ACI-1053575]; National Science Foundation
and Information Systems Laboratory at NCSU; National Science Foundation
and Stampede; National Science Foundation EaSM program at NCSU
[AGS-1049200]
FX This study is funded by the National Science Foundation EaSM program
(AGS-1049200) at NCSU. The following agencies have prepared the data
sets used in this study: the U.S. EPA (North American emissions
processing), Environment Canada, Mexican Secretariat of the Environment
and Natural Resources (Secretaria del Medio Ambiente y Recursos
Naturales, SE-MARNAT) and National Institute of Ecology (Instituto
Nacional de Ecologia - INE) (North American national emissions
inventories), the European Centre for Medium Range Weather Forecasting
Global and Regional Earth-system (Atmosphere) Monitoring using Satellite
and in situ data (ECMWF/GEMS) project and Meteo France/Centre national
de recherches meteorologiques (CNRM-GAME) for the Monitoring Atmospheric
Composition and Climate (MACC) ICONs/BCONs. Meteorological ICONs/BCONs
are provided by the National Center for Environmental Protection.
Ambient North American concentration measurements are provided by
several US networks (AQS, CASTNET, IMPROVE, SEARCH, and STN). North
American precipitation-chemistry measurements are provided by several US
networks (CASTNET, and NADP). GPCC precipitation data are provided by
the National Oceanic and Atmospheric Administration's Earth System
Research Laboratory in the Physical Sciences Division (NOAA/OAR/ESRL
PSD), Boulder, Colorado, USA, from their web site at
http://www.esrl.noaa.gov/psd/. The 2006 and 2010 SOA/OC data at RTP, NC,
Bakersfield and Pasadena, CA, were provided by John Offenberg, U.S. EPA.
Cloud variables were provided by MODIS. We thank Georg Grell, NOAA,
Christian Hogrefe, US EPA, Paul Makar, Environment Canada, Christoph
Knote, NCAR, and Patrick Campbell, NCSU, for helpful discussions on
inputs and outputs of AQMEII model intercomparison. We would also like
to acknowledge high-performance computing support from Yellowstone
(ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information
Systems Laboratory, sponsored by the National Science Foundation and
Information Systems Laboratory, sponsored by the National Science
Foundation and Stampede, provided as an Extreme Science and Engineering
Discovery Environment (XSEDE) digital service by the Texas Advanced
Computing Center (TACC) (http://www.tacc.utexas.edu), which is supported
by National Science Foundation grant number ACI-1053575.
NR 51
TC 5
Z9 6
U1 1
U2 12
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 7
BP 2095
EP 2117
DI 10.5194/gmd-8-2095-2015
PG 23
WC Geosciences, Multidisciplinary
SC Geology
GA CO1LQ
UT WOS:000358917100011
ER
PT J
AU Sproles, EA
Leibowitz, SG
Reager, JT
Wigington, PJ
Famiglietti, JS
Patil, SD
AF Sproles, E. A.
Leibowitz, S. G.
Reager, J. T.
Wigington, P. J., Jr.
Famiglietti, J. S.
Patil, S. D.
TI GRACE storage-runoff hystereses reveal the dynamics of regional
watersheds
SO HYDROLOGY AND EARTH SYSTEM SCIENCES
LA English
DT Article
ID WESTERN UNITED-STATES; DATA ASSIMILATION SYSTEM; CLIMATE-CHANGE;
GROUNDWATER DEPLETION; OREGON CASCADES; SOIL-MOISTURE; RIVER-BASIN;
MOUNTAIN HYDROLOGY; SNOWPACK; MODEL
AB We characterize how regional watersheds function as simple, dynamic systems through a series of hysteresis loops using measurements from NASA's Gravity Recovery and Climate Experiment (GRACE) satellites. These loops illustrate the temporal relationship between runoff and terrestrial water storage in three regional-scale watersheds (> 150 000 km(2)) of the Columbia River Basin, USA and Canada. The shape and size of the hysteresis loops are controlled by the climate, topography, and geology of the watershed. The direction of the hystereses for the GRACE signals moves in opposite directions from the isolated groundwater hystereses. The subsurface water (soil moisture and groundwater) hystereses more closely resemble the storage-runoff relationship of a soil matrix. While the physical processes underlying these hystereses are inherently complex, the vertical integration of terrestrial water in the GRACE signal encapsulates the processes that govern the non-linear function of regional-scale watersheds. We use this process-based understanding to test how GRACE data can be applied prognostically to predict seasonal runoff (mean Nash-Sutcliffe Efficiency of 0.91) and monthly runoff during the low flow/high demand month of August (mean Nash-Sutcliffe Efficiency of 0.77) in all three watersheds. The global nature of GRACE data allows this same methodology to be applied in other regional-scale studies, and could be particularly useful in regions with minimal data and in trans-boundary watersheds.
C1 [Sproles, E. A.] US EPA, Natl Hlth & Environm Effects Res Lab, Oak Ridge Inst Sci & Technol, Corvallis, OR 97333 USA.
[Sproles, E. A.] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA.
[Leibowitz, S. G.; Wigington, P. J., Jr.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Reager, J. T.; Famiglietti, J. S.] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA.
[Patil, S. D.] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor LL57 2UW, Gwynedd, Wales.
[Sproles, E. A.] Univ La Serena, Ctr Estudios Avanzados Zonas Aridas, La Serena 1305, Chile.
RP Sproles, EA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Oak Ridge Inst Sci & Technol, 200 SW 35th St, Corvallis, OR 97333 USA.
EM eric.sproles@gmail.com
RI Patil, Sopan/E-8497-2011;
OI Patil, Sopan/0000-0002-8575-5220; Sproles, Eric/0000-0003-1245-1653
FU NASA MEaSUREs Program; US Environmental Protection Agency
FX The authors would like to thank Matthew Rodell and Felix Landerer for
their expertise in understanding GRACE data during the initial stages of
the research. GRACE terrestrial data were processed by Sean Swenson,
supported by the NASA MEaSUREs Program, and are available at
http://grace.jpl.nasa.gov. The GLDAS and NLDAS data used in this study
were acquired as part of the mission of NASA's Earth Science Division
and archived and distributed by the Goddard Earth Sciences Data and
Information Services Center. We would like to thank the reviewers of the
manuscript that have helped improve its overall quality. Additionally,
Tim Kerr provided objective feedback and comments on the research
findings. The information in this document has been funded entirely by
the US Environmental Protection Agency, in part by an appointment to the
Internship/Research Participation Program at the Office of Research and
Development, U.S. Environmental Protection Agency, administered by the
Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and EPA. This manuscript
has been subjected to Agency review and has been approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 75
TC 3
Z9 3
U1 3
U2 16
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1027-5606
EI 1607-7938
J9 HYDROL EARTH SYST SC
JI Hydrol. Earth Syst. Sci.
PY 2015
VL 19
IS 7
BP 3253
EP 3272
DI 10.5194/hess-19-3253-2015
PG 20
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA CO1MA
UT WOS:000358918200016
ER
PT S
AU Harper, S
Wohlleben, W
Doa, M
Nowack, B
Clancy, S
Canady, R
Maynard, A
AF Harper, Stacey
Wohlleben, Wendel
Doa, Maria
Nowack, Bernd
Clancy, Shaun
Canady, Richard
Maynard, Andrew
GP IOP
TI Measuring Nanomaterial Release from Carbon Nanotube Composites: Review
of the State of the Science
SO 4TH INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS
(NANOSAFE2014)
SE Journal of Physics Conference Series
LA English
DT Proceedings Paper
CT 4th International Conference on Safe Production and Use of Nanomaterials
(Nanosafe)
CY NOV 18-20, 2014
CL Grenoble, FRANCE
ID EPOXY-BASED NANOCOMPOSITE; NANOPARTICLE RELEASE; POLYMER COMPOSITES;
POTENTIAL RELEASE; LIFE-CYCLE; ENGINEERED NANOMATERIALS; AIRBORNE
PARTICLES; EXPOSURE; ENVIRONMENT; SCENARIOS
AB Hazard studies of "as-produced" nanomaterials are increasingly available, yet a critical gap exists in exposure science that may impede safe development of nanomaterials. The gap is that we do not understand what is actually released because nanomaterials can change when released in ways that are not understood. We also generally do not have methods capable of quantitatively measuring what is released to support dose assessment. This review presents a case study of multi-walled carbon nanotubes (MWCNTs) for the measurement challenge to bridge this gap. As the use and value of MWCNTs increases, methods to measure what is released in ways relevant to risk evaluation are critically needed if products containing these materials are to be economically, environmentally, and socially sustainable. This review draws on the input of over 50 experts engaged in a program of workshops and technical report writing to address the release of MWCNTs from nanocomposite materials across their life cycle. The expert analyses reveals that new and sophisticated methods are required to measure and assess MWCNT exposures for realistic exposure scenarios. Furthermore, method requirements vary with the materials and conditions of release across life cycle stages of products. While review shows that the likelihood of significant release of MWCNTs appears to be low for many stages of composite life cycle, measurement methods are needed so that exposures from MWCNT-composites are understood and managed. In addition, there is an immediate need to refocus attention from study of "as-produced" nanomaterials to coordinated research on actual release scenarios.
C1 [Harper, Stacey] Oregon State Univ, Environm & Mol Toxicol, Chem Biol & Environm Engn, Corvallis, OR 97331 USA.
[Wohlleben, Wendel] BASF SE, Mat Phys, D-67056 Ludwigshafen, Germany.
[Doa, Maria] US EPA, Washington, DC 20460 USA.
[Nowack, Bernd] EMPA, Swiss Fed Labs Mat Sci & Technol, Technol & Soc Lab, CH-9014 St Gallen, Switzerland.
[Clancy, Shaun] Evonik Corp, Parsippany, NJ 07054 USA.
[Canady, Richard] ILSI Res Fdn, Ctr Risk Sci Innovat & Applicat, Washington, DC 20005 USA.
[Maynard, Andrew] Univ Michigan, Risk Sci Ctr, Ann Arbor, MI 48109 USA.
RP Harper, S (reprint author), Oregon State Univ, Environm & Mol Toxicol, Chem Biol & Environm Engn, Corvallis, OR 97331 USA.
EM rcanady@ilsi.org
RI Nowack, Bernd/B-6425-2008
OI Nowack, Bernd/0000-0002-5676-112X
NR 90
TC 4
Z9 4
U1 2
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 1742-6588
J9 J PHYS CONF SER
PY 2015
VL 617
AR 012026
DI 10.1088/1742-6596/617/1/012026
PG 19
WC Nanoscience & Nanotechnology; Physics, Multidisciplinary
SC Science & Technology - Other Topics; Physics
GA BD1HU
UT WOS:000358033300026
ER
PT J
AU Fu, X
Wang, SX
Ran, LM
Pleim, JE
Cooter, E
Bash, JO
Benson, V
Hao, JM
AF Fu, X.
Wang, S. X.
Ran, L. M.
Pleim, J. E.
Cooter, E.
Bash, J. O.
Benson, V.
Hao, J. M.
TI Estimating NH3 emissions from agricultural fertilizer application in
China using the bi-directional CMAQ model coupled to an agro-ecosystem
model
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID YANGTZE-RIVER DELTA; AIR-QUALITY MODELS; AMMONIA EMISSIONS; ATMOSPHERE
EXCHANGE; NITROGEN DEPOSITION; PARTICULATE MATTER; INORGANIC AEROSOLS;
MANAGEMENT-SYSTEMS; HAZE POLLUTION; IMPACT
AB Atmospheric ammonia (NH3) plays an important role in atmospheric aerosol chemistry. China is one of the largest NH3 emitting countries with the majority of NH3 emissions coming from agricultural practices, such as fertilizer application and livestock production. The current NH3 emission estimates in China are mainly based on pre-defined emission factors that lack temporal or spatial details, which are needed to accurately predict NH3 emissions. This study provides the first online estimate of NH3 emissions from agricultural fertilizer application in China, using an agricultural fertilizer modeling system which couples a regional air quality model (the Community Multi-scale Air Quality model, or CMAQ) and an agro-ecosystem model (the Environmental Policy Integrated Climate model, or EPIC). This method improves the spatial and temporal resolution of NH3 emissions from this sector.
We combined the cropland area data of 14 crops from 2710 counties with the Moderate Resolution Imaging Spectroradiometer (MODIS) land use data to determine the crop distribution. The fertilizer application rates and methods for different crops were collected at provincial or agricultural region levels. The EPIC outputs of daily fertilizer application and soil characteristics were input into the CMAQ model and the hourly NH3 emissions were calculated online with CMAQ running. The estimated agricultural fertilizer NH3 emissions in this study were approximately 3 Tg in 2011. The regions with the highest modeled emission rates are located in the North China Plain. Seasonally, peak ammonia emissions occur from April to July. Compared with previous researches, this study considers an increased number of influencing factors, such as meteorological fields, soil and fertilizer application, and provides improved NH3 emissions with higher spatial and temporal resolution.
C1 [Fu, X.; Wang, S. X.; Hao, J. M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Fu, X.; Wang, S. X.] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Ran, L. M.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA.
[Pleim, J. E.; Cooter, E.; Bash, J. O.] US EPA, Res Triangle Pk, NC 27711 USA.
[Benson, V.] Benson Consulting, Columbia, MO USA.
[Hao, J. M.] Tsinghua Univ, Collaborat Innovat Ctr Reg Environm Qual, Beijing 100084, Peoples R China.
RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI wang, shuxiao/H-5990-2011; Pleim, Jonathan Pleim/C-1331-2017
OI wang, shuxiao/0000-0001-9727-1963; Pleim, Jonathan
Pleim/0000-0001-6190-6082
FU National Natural Science Foundation of China [21221004]; MEP's special
funds for Research on Public Welfare [201309009, 201409002]; Strategic
Priority Research Program of the Chinese Academy of Sciences
[XBD05020300]
FX This work was sponsored by the National Natural Science Foundation of
China (21221004), MEP's special funds for Research on Public Welfare
(201309009, 201409002), and the Strategic Priority Research Program of
the Chinese Academy of Sciences (XBD05020300). This work was completed
on the "Explorer 100" cluster system of Tsinghua National Laboratory for
Information Science and Technology. The authors also appreciate the help
of Jimmy R. Williams at Texas A&M University, Youlu Bai from the Chinese
Academy of Agriculture Sciences, and Margaret Ledyard-Marks in UNC
Institute for the Environment. Although this work was reviewed by EPA
and approved for publication, it may not necessarily reflect official
agency policy. Mention of commercial products does not constitute
endorsement by the agency.
NR 53
TC 9
Z9 9
U1 13
U2 41
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 12
BP 6637
EP 6649
DI 10.5194/acp-15-6637-2015
PG 13
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CL6ZC
UT WOS:000357117500006
ER
PT J
AU Arcaya, MC
Arcaya, AL
Subramanian, SV
AF Arcaya, Mariana C.
Arcaya, Alyssa L.
Subramanian, S. V.
TI Inequalities in health: definitions, concepts, and theories
SO GLOBAL HEALTH ACTION
LA English
DT Review
DE health disparities; inequality; inequity; theory
ID SOCIAL INEQUALITIES; LIFE EXPECTANCY; SOCIOECONOMIC INEQUALITIES; INCOME
INEQUALITY; MEDICAL GEOGRAPHY; EPIDEMIOLOGY; DETERMINANTS; DISPARITIES;
EQUITY; EXPLANATION
AB Individuals from different backgrounds, social groups, and countries enjoy different levels of health. This article defines and distinguishes between unavoidable health inequalities and unjust and preventable health inequities. We describe the dimensions along which health inequalities are commonly examined, including across the global population, between countries or states, and within geographies, by socially relevant groupings such as race/ethnicity, gender, education, caste, income, occupation, and more. Different theories attempt to explain group-level differences in health, including psychosocial, material deprivation, health behavior, environmental, and selection explanations. Concepts of relative versus absolute; dose-response versus threshold; composition versus context; place versus space; the life course perspective on health; causal pathways to health; conditional health effects; and group-level versus individual differences are vital in understanding health inequalities. We close by reflecting on what conditions make health inequalities unjust, and to consider the merits of policies that prioritize the elimination of health disparities versus those that focus on raising the overall standard of health in a population.
C1 [Arcaya, Mariana C.; Subramanian, S. V.] Boston Univ, Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02215 USA.
[Arcaya, Alyssa L.] US EPA, New York, NY USA.
RP Subramanian, SV (reprint author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 677 Huntington Ave, Boston, MA 02115 USA.
EM svsubram@hsph.harvard.edu
NR 69
TC 6
Z9 6
U1 4
U2 23
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 1654-9880
J9 GLOBAL HEALTH ACTION
JI Glob. Health Action
PY 2015
VL 8
AR 27106
DI 10.3402/gha.v8.27106
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CL4RL
UT WOS:000356941000001
PM 28156715
ER
PT J
AU Hildenbrand, ZL
Osorio, A
Carlton, DD
Fontenot, BE
Walton, JL
Hunt, LR
Oka, H
Hopkins, D
Bjorndal, B
Schug, KA
AF Hildenbrand, Zacariah L.
Osorio, Alexandra
Carlton, Doug D., Jr.
Fontenot, Brian E.
Walton, Jayme L.
Hunt, Laura R.
Oka, Hyppolite
Hopkins, Dan
Bjorndal, Bryan
Schug, Kevin A.
TI Rapid Analysis of Eukaryotic Bioluminescence to Assess Potential
Groundwater Contamination Events
SO JOURNAL OF CHEMISTRY
LA English
DT Article
ID DRINKING-WATER WELLS; GAS EXTRACTION
AB Here we present data using a bioluminescent dinoflagellate, Pyrocystis lunula, in a toxicological bioassay to rapidly assess potential instances of groundwater contamination associated with natural gas extraction. P. lunula bioluminescence can be quantified using spectrophotometry as a measurement of organismal viability, with normal bioluminescent output declining with increasing concentration(s) of aqueous toxicants. Glutaraldehyde and hydrochloric acid (HCl), components used in hydraulic fracturing and shale acidization, triggered significant toxicological responses in as little as 4 h. Conversely, P. lunula was not affected by the presence of arsenic, selenium, barium, and strontium, naturally occurring heavy metal ions potentially associated with unconventional drilling activities. If exogenous compounds, such as glutaraldehyde and HCl, are thought to have been introduced into groundwater, quantification of P. lunula bioluminescence after exposure to water samples can serve as a cost-effective detection and risk assessment tool to rapidly assess the impact of putative contamination events attributed to unconventional drilling activity.
C1 [Hildenbrand, Zacariah L.; Carlton, Doug D., Jr.; Fontenot, Brian E.; Hunt, Laura R.; Oka, Hyppolite; Schug, Kevin A.] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA.
[Hildenbrand, Zacariah L.; Carlton, Doug D., Jr.; Fontenot, Brian E.; Hunt, Laura R.; Oka, Hyppolite; Schug, Kevin A.] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA.
[Hildenbrand, Zacariah L.] Inform Environm LLC, Dallas, TX 75206 USA.
[Osorio, Alexandra; Bjorndal, Bryan] Assure Controls Inc, Vista, CA 92081 USA.
[Fontenot, Brian E.; Hunt, Laura R.] US EPA, Water Qual Protect Div, Dallas, TX 75202 USA.
[Walton, Jayme L.] SWCA Environm Consultants, Arlington, TX 76006 USA.
[Hopkins, Dan] Geotech Environm Equipment Inc, Carrollton, TX 75006 USA.
RP Schug, KA (reprint author), Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA.
EM kschug@uta.edu
NR 13
TC 0
Z9 0
U1 4
U2 10
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 2090-9063
EI 2090-9071
J9 J CHEM-NY
JI J. Chem.
PY 2015
AR 957608
DI 10.1155/2015/957608
PG 6
WC Chemistry, Multidisciplinary
SC Chemistry
GA CL2JV
UT WOS:000356770600001
ER
PT J
AU McAlary, T
Groenevelt, H
Disher, S
Arnold, J
Seethapathy, S
Sacco, P
Crump, D
Schumacher, B
Hayes, H
Johnson, P
Gorecki, T
AF McAlary, Todd
Groenevelt, Hester
Disher, Stephen
Arnold, Jason
Seethapathy, Suresh
Sacco, Paolo
Crump, Derrick
Schumacher, Brian
Hayes, Heidi
Johnson, Paul
Gorecki, Tadeusz
TI Passive sampling for volatile organic compounds in indoor air-controlled
laboratory comparison of four sampler types (vol 17, pg 896, 2015)
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Correction
C1 [McAlary, Todd; Groenevelt, Hester] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Eurofins Air Tox Inc, Folsom, CA USA.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Air Tox Ltd, Folsom, CA USA.
[Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy.
[Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England.
[Schumacher, Brian] US EPA, Las Vegas, NV 89193 USA.
[Johnson, Paul] Arizona State Univ, Tempe, AZ USA.
RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane 2, Guelph, ON N1G 5G3, Canada.
EM tmcalary@geosyntec.com
NR 1
TC 0
Z9 0
U1 1
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 6
BP 1190
EP 1190
DI 10.1039/c5em90021b
PG 1
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CK2QW
UT WOS:000356057300019
PM 25994121
ER
PT J
AU Collier, SA
Wade, TJ
Sams, EA
Hlavsa, MC
Dufour, AP
Beach, MJ
AF Collier, Sarah A.
Wade, Timothy J.
Sams, Elizabeth A.
Hlavsa, Michele C.
Dufour, Alfred P.
Beach, Michael J.
TI Swimming in the USA: beachgoer characteristics and health outcomes at US
marine and freshwater beaches
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE gastrointestinal illness; health outcomes; healthcare utilization;
natural waters; recreational water; swimming
ID RAPIDLY MEASURED INDICATORS; UNITED-STATES; RECREATIONAL WATER; DISEASE
OUTBREAKS; OTITIS-EXTERNA; ILLNESS; QUALITY; RISK; SURVEILLANCE;
PATHOGENS
AB Swimming in lakes and oceans is popular, but little is known about the demographic characteristics, behaviors, and health risks of beachgoers on a national level. Data from a prospective cohort study of beachgoers at multiple marine and freshwater beaches in the USA were used to describe beachgoer characteristics and health outcomes for swimmers and non-swimmers. This analysis included 54,250 participants. Most (73.2%) entered the water; of those, 65.1% put their head under water, 41.3% got water in their mouth and 18.5% swallowed water. Overall, 16.3% of beachgoers reported any new health problem. Among swimmers, 6.6% reported gastrointestinal (GI) illness compared with 5.5% of non-swimmers (unadjusted chi(2) p < 0.001); 6.0% of swimmers and 4.9% of non-swimmers reported respiratory illness (p < 0.001); 1.8% of swimmers and 1.0% of non-swimmers reported ear problems (p < 0.001); and 3.9% of swimmers and 2.4% of non-swimmers experienced a rash (p < 0.001). Overall, swimmers reported a higher unadjusted incidence of GI illness and earaches than nonswimmers. Current surveillance systems might not detect individual cases and outbreaks of illness associated with swimming in natural water. Better knowledge of beachgoer characteristics, activities, and health risks associated with swimming in natural water can improve disease surveillance and prioritize limited resources.
C1 [Collier, Sarah A.; Hlavsa, Michele C.; Beach, Michael J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Wade, Timothy J.; Sams, Elizabeth A.] US EPA, Off Res & Dev, Chapel Hill, NC USA.
[Dufour, Alfred P.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Collier, SA (reprint author), Ctr Dis Control & Prevent, Mailstop C-09,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM SCollier@cdc.gov
FU Intramural CDC HHS [CC999999]
NR 30
TC 3
Z9 3
U1 1
U2 8
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 2
BP 531
EP 543
DI 10.2166/wh.2014.095
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CK2ET
UT WOS:000356024100022
PM 26042984
ER
PT J
AU Ferreira, WR
Ligeiro, R
Macedo, DR
Hughes, RM
Kaufmann, PR
Oliveira, LG
Callisto, M
AF Ferreira, Wander R.
Ligeiro, Raphael
Macedo, Diego R.
Hughes, Robert M.
Kaufmann, Philip R.
Oliveira, Leandro G.
Callisto, Marcos
TI Is the diet of a typical shredder related to the physical habitat of
headwater streams in the Brazilian Cerrado?
SO ANNALES DE LIMNOLOGIE-INTERNATIONAL JOURNAL OF LIMNOLOGY
LA English
DT Article
DE Gut contents; aquatic macroinvertebrates; trophic guilds; tropical
streams; stream habitat conservation
ID PHYLLOICUS SP TRICHOPTERA; LEAF-LITTER; ORGANIC-MATTER; BENTHIC
MACROINVERTEBRATES; HIERARCHICAL FRAMEWORK; ENVIRONMENTAL-FACTORS;
FEEDING PLASTICITY; AUSTRALIAN STREAMS; PARTICULATE MATTER; MULTIMETRIC
INDEX
AB Macroinvertebrates are important for processing leaf detritus in temperate streams, but studies about their role in tropical streams often present conflicting results. Via digestive tract analyses, we assessed the diets of Phylloicus sp. larvae (Trichoptera: Calamoceratidae), collected from streams of two southeastern Brazil river basins (Araguari, Sao Francisco). We classified gut contents as coarse particulate organic matter (CPOM), fine particulate organic matter (FPOM), algae, animal tissue, vascular plant tissue and mineral material. We hypothesized that the diets of Phylloicus larvae would be related to the physical habitat of the streams (e.g., riparian vegetation, organic matter availability and morphological characteristics), larval size and river basin. Although FPOM content predominated in both basins, we found greater CPOM content in Phylloicus larvae of Upper Sao Francisco sites, and this food item was related to greater riparian vegetation canopy density. The FPOM content was greater in larvae of Upper Araguari sites, and this food item was correlated with greater instream brush cover. Algae, animal tissue, vascular plant tissue and mineral material were very rare in the digestive tracts, and therefore could not be explained. These results indicate the importance of riparian vegetation structure in modulating feeding habitats of macroinvertebrates. We conclude that the Phylloicus larvae had more flexibility in what they eat than we might expect based on their traditional classification as shredders. Therefore, trusting in published classifications, ignoring regional or local differences, may be inaccurate. Instead, regional studies of feeding habits are needed for accurate classifications of invertebrate taxa into trophic guilds.
C1 [Ferreira, Wander R.; Ligeiro, Raphael; Macedo, Diego R.; Callisto, Marcos] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Lab Ecol Bentos, BR-31270901 Belo Horizonte, MG, Brazil.
[Macedo, Diego R.] Inst Brasileiro Geog & Estat, BR-30310150 Belo Horizonte, MG, Brazil.
[Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97331 USA.
[Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Kaufmann, Philip R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Oliveira, Leandro G.] Univ Fed Goias, Inst Ciencias Biol, Dept Ecol, BR-74001970 Goiania, Go, Brazil.
RP Ferreira, WR (reprint author), Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Lab Ecol Bentos, Av Antonio Carlos 6627,CP 486, BR-31270901 Belo Horizonte, MG, Brazil.
EM ferreirawr@gmail.com
RI Ligeiro, Raphael/K-7791-2015; Callisto, Marcos/O-4930-2015; Macedo,
Diego/G-2506-2015
OI Ligeiro, Raphael/0000-0001-9717-5461; Callisto,
Marcos/0000-0003-2341-4700; Macedo, Diego/0000-0002-1178-4969
FU CNPq [471385/2011-5, 302960/2011-2]; FAPEMIG [PPM-00077/13]
FX We are grateful to the Peixe-Vivo Program of Companhia Energetica de
Minas Gerais, Pesquisa & Desenvolvimento/Agencia Nacional de Energia
Eletrica/Companhia Energetica de Minas Gerais-P&D ANEEL/CEMIG (GT-487),
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Conselho
Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao de
Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), and
Fulbright-Brasil for financial support; Carlos Bernardo Mascarenhas
Alves for logistical support; colleagues from the Federal University of
Minas Gerais Benthic Ecology Laboratory, Federal Center of Technological
Education of Minas Gerais, Federal University of Lavras, and Pontifical
Catholic University of Minas Gerais for help with field collections; and
researchers at the U.S. EPA Western Ecology Division, Corvallis, Oregon
for discussions during an October 2011 workshop. MC received CNPq
research grant and research fellowship nos. 471385/2011-5 and
302960/2011-2 and FAPEMIG research grant PPM-00077/13. Tony Olsen, Marc
Weber, and Phil Larsen of the Corvallis US Environmental Protection
Agency Laboratory (Oregon, USA) kindly assisted in developing spatial
sampling designs and selecting wadeable stream sample sites. The
manuscript was improved via reviews by William Gerth of Oregon State
University, and four anonymous referees. This manuscript was subjected
to review by the US EPA National Health and Environmental Effects
Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 63
TC 1
Z9 2
U1 1
U2 7
PU EDP SCIENCES S A
PI LES ULIS CEDEX A
PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A,
FRANCE
SN 0003-4088
EI 2100-000X
J9 ANN LIMNOL-INT J LIM
JI Ann. Limnol.-Int. J. Limnol.
PY 2015
VL 51
IS 2
BP 115
EP 124
DI 10.1051/limn/2015004
PG 10
WC Limnology
SC Marine & Freshwater Biology
GA CJ5VX
UT WOS:000355561500003
ER
PT J
AU Hayes, PL
Carlton, AG
Baker, KR
Ahmadov, R
Washenfelder, RA
Alvarez, S
Rappengluck, B
Gilman, JB
Kuster, WC
de Gouw, JA
Zotter, P
Prevot, ASH
Szidat, S
Kleindienst, TE
Offenberg, JH
Ma, PK
Jimenez, JL
AF Hayes, P. L.
Carlton, A. G.
Baker, K. R.
Ahmadov, R.
Washenfelder, R. A.
Alvarez, S.
Rappenglueck, B.
Gilman, J. B.
Kuster, W. C.
de Gouw, J. A.
Zotter, P.
Prevot, A. S. H.
Szidat, S.
Kleindienst, T. E.
Offenberg, J. H.
Ma, P. K.
Jimenez, J. L.
TI Modeling the formation and aging of secondary organic aerosols in Los
Angeles during CalNex 2010
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID VOLATILITY BASIS-SET; AIR-POLLUTION SOURCES; MASS-SPECTROMETRY;
MEXICO-CITY; SOURCE APPORTIONMENT; TRACER COMPOUNDS; ELEMENTAL RATIO;
UNITED-STATES; AQUEOUS-PHASE; SOA FORMATION
AB Four different literature parameterizations for the formation and evolution of urban secondary organic aerosol (SOA) frequently used in 3-D models are evaluated using a 0-D box model representing the Los Angeles metropolitan region during the California Research at the Nexus of Air Quality and Climate Change (CalNex) 2010 campaign. We constrain the model predictions with measurements from several platforms and compare predictions with particle-and gas-phase observations from the CalNex Pasadena ground site. That site provides a unique opportunity to study aerosol formation close to anthropogenic emission sources with limited recirculation. The model SOA that formed only from the oxidation of VOCs (V-SOA) is insufficient to explain the observed SOA concentrations, even when using SOA parameterizations with multi-generation oxidation that produce much higher yields than have been observed in chamber experiments, or when increasing yields to their upper limit estimates accounting for recently reported losses of vapors to chamber walls. The Community Multiscale Air Quality (WRF-CMAQ) model (version 5.0.1) provides excellent predictions of secondary inorganic particle species but underestimates the observed SOA mass by a factor of 25 when an older VOC-only parameterization is used, which is consistent with many previous model-measurement comparisons for pre-2007 anthropogenic SOA modules in urban areas.
Including SOA from primary semi-volatile and intermediate-volatility organic compounds (P-S/IVOCs) following the parameterizations of Robinson et al. (2007), Grieshop et al. (2009), or Pye and Seinfeld (2010) improves model-measurement agreement for mass concentration. The results from the three parameterizations show large differences (e.g., a factor of 3 in SOA mass) and are not well constrained, underscoring the current uncertainties in this area. Our results strongly suggest that other precursors besides VOCs, such as P-S/IVOCs, are needed to explain the observed SOA concentrations in Pasadena. All the recent parameterizations overpredict urban SOA formation at long photochemical ages (approximate to 3 days) compared to observations from multiple sites, which can lead to problems in regional and especially global modeling. However, reducing IVOC emissions by one-half in the model to better match recent IVOC measurements improves SOA predictions at these long photochemical ages.
Among the explicitly modeled VOCs, the precursor compounds that contribute the greatest SOA mass are methylbenzenes. Measured polycyclic aromatic hydrocarbons (naphthalenes) contribute 0.7% of the modeled SOA mass. The amounts of SOA mass from diesel vehicles, gasoline vehicles, and cooking emissions are estimated to be 16-27, 35-61, and 19-35 %, respectively, depending on the parameterization used, which is consistent with the observed fossil fraction of urban SOA, 71(+/- 3) %. The relative contribution of each source is uncertain by almost a factor of 2 depending on the parameterization used. In-basin biogenic VOCs are predicted to contribute only a few percent to SOA. A regional SOA background of approximately 2.1 mu g m(-3) is also present due to the long-distance transport of highly aged OA, likely with a substantial contribution from regional biogenic SOA. The percentage of SOA from diesel vehicle emissions is the same, within the estimated uncertainty, as reported in previous work that analyzed the weekly cycles in OA concentrations (Bahreini et al., 2012; Hayes et al., 2013). However, the modeling work presented here suggests a strong anthropogenic source of modern carbon in SOA, due to cooking emissions, which was not accounted for in those previous studies and which is higher on weekends.
Lastly, this work adapts a simple two-parameter model to predict SOA concentration and O/C from urban emissions. This model successfully predicts SOA concentration, and the optimal parameter combination is very similar to that found for Mexico City. This approach provides a computationally inexpensive method for predicting urban SOA in global and climate models. We estimate pollution SOA to account for 26 Tg yr(-1) of SOA globally, or 17% of global SOA, one-third of which is likely to be non-fossil.
C1 [Hayes, P. L.; Ahmadov, R.; Washenfelder, R. A.; Gilman, J. B.; de Gouw, J. A.; Jimenez, J. L.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Hayes, P. L.; Jimenez, J. L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Hayes, P. L.; Ma, P. K.] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Baker, K. R.; Kleindienst, T. E.; Offenberg, J. H.] US EPA, Res Triangle Pk, NC 27711 USA.
[Ahmadov, R.; Washenfelder, R. A.; Gilman, J. B.; Kuster, W. C.; de Gouw, J. A.] NOAA, Earth Syst Res Lab, Boulder, CO USA.
[Alvarez, S.; Rappenglueck, B.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX 77004 USA.
[Zotter, P.; Prevot, A. S. H.] Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
[Szidat, S.] Univ Bern, Dept Chem & Biochem, Bern, Switzerland.
[Szidat, S.] Univ Bern, Oeschger Ctr Climate Change Res, Bern, Switzerland.
RP Hayes, PL (reprint author), Univ Colorado, CIRES, Boulder, CO 80309 USA.
EM patrick.hayes@umontreal.ca; jose.jimenez@colorado.edu
RI Prevot, Andre/C-6677-2008; Ahmadov, Ravan/F-2036-2011; Carlton,
Annmarie/A-7867-2011; Washenfelder, Rebecca/E-7169-2010; Jimenez,
Jose/A-5294-2008; Szidat, Sonke/D-6706-2011; Offenberg,
John/C-3787-2009; Gilman, Jessica/E-7751-2010; Kuster,
William/E-7421-2010; Manager, CSD Publications/B-2789-2015; de Gouw,
Joost/A-9675-2008
OI Prevot, Andre/0000-0002-9243-8194; Ahmadov, Ravan/0000-0002-6996-7071;
Carlton, Annmarie/0000-0002-8574-1507; Washenfelder,
Rebecca/0000-0002-8106-3702; Jimenez, Jose/0000-0001-6203-1847; Szidat,
Sonke/0000-0002-1824-6207; Offenberg, John/0000-0002-0213-4024; Gilman,
Jessica/0000-0002-7899-9948; Kuster, William/0000-0002-8788-8588; de
Gouw, Joost/0000-0002-0385-1826
FU US DOE (BER, ASR program) [DE-SC0006035, DE-SC0006711, DE-SC0011105];
NSF [AGS-1243354, AGS-1360834]; NOAA [NA13OAR4310063]; CIRES Visiting
Fellows Program; NSERC; Universite de Montreal; US Weather Research
Program within the NOAA/OAR Office of Weather and Air Quality; [CARB
08-319]; [CARB 11-305]
FX This work was partially supported by CARB 08-319 and CARB 11-305; US DOE
(BER, ASR program) DE-SC0006035, DE-SC0006711, and DE-SC0011105; NSF
AGS-1243354 and AGS-1360834; and NOAA NA13OAR4310063. P. L. Hayes is
also grateful for a fellowship from the CIRES Visiting Fellows Program,
and P. L. Hayes and P. K. Ma acknowledge support from a NSERC Discovery
Grant and the Universite de Montreal. The authors thank Chris J.
Hennigan (UMBC) and Allen L. Robinson (CMU) for providing the
naphthalene and methylnaphthalene data. We also thank John S. Holloway
(NOAA) for providing CO data, Roya Bahreini (University of
California-Riverside) and Ann M. Middlebrook (NOAA) for providing OA
data from the NOAA P3, and Stuart A. McKeen (NOAA) for helpful
discussions. R. Ahmadov is supported by the US Weather Research Program
within the NOAA/OAR Office of Weather and Air Quality. The US
Environmental Protection Agency through its Office of Research and
Development collaborated in the research described here. The manuscript
was subjected to external peer review and has been cleared for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 109
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Z9 19
U1 16
U2 89
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 10
BP 5773
EP 5801
DI 10.5194/acp-15-5773-2015
PG 29
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BM
UT WOS:000355289200028
ER
PT J
AU Guo, H
Xu, L
Bougiatioti, A
Cerully, KM
Capps, SL
Hite, JR
Carlton, AG
Lee, SH
Bergin, MH
Ng, NL
Nenes, A
Weber, RJ
AF Guo, H.
Xu, L.
Bougiatioti, A.
Cerully, K. M.
Capps, S. L.
Hite, J. R., Jr.
Carlton, A. G.
Lee, S. -H.
Bergin, M. H.
Ng, N. L.
Nenes, A.
Weber, R. J.
TI Fine-particle water and pH in the southeastern United States
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; LIQUID PHASE-SEPARATION;
THERMODYNAMIC-EQUILIBRIUM MODEL; ATMOSPHERIC PARTICLES; HYGROSCOPIC
GROWTH; RELATIVE-HUMIDITY; ALPHA-PINENE; INORGANIC AEROSOLS;
MASS-SPECTROMETER; AMMONIUM-SULFATE
AB Particle water and pH are predicted using meteorological observations (relative humidity (RH), temperature (T)), gas/particle composition, and thermodynamic modeling (ISORROPIA-II). A comprehensive uncertainty analysis is included, and the model is validated. We investigate mass concentrations of particle water and related particle pH for ambient fine-mode aerosols sampled in a relatively remote Alabama forest during the Southern Oxidant and Aerosol Study (SOAS) in summer and at various sites in the southeastern US during different seasons, as part of the Southeastern Center for Air Pollution and Epidemiology (SCAPE) study. Particle water and pH are closely linked; pH is a measure of the particle H+ aqueous concentration and depends on both the presence of ions and amount of particle liquid water. Levels of particle water, in turn, are determined through water uptake by both the ionic species and organic compounds. Thermodynamic calculations based on measured ion concentrations can predict both pH and liquid water but may be biased since contributions of organic species to liquid water are not considered. In this study, contributions of both the inorganic and organic fractions to aerosol liquid water were considered, and predictions were in good agreement with measured liquid water based on differences in ambient and dry light scattering coefficients (prediction vs. measurement: slope = 0.91, intercept = 0.5 mu gm(-3), R-2 = 0.75). ISORROPIA-II predictions were confirmed by good agreement between predicted and measured ammonia concentrations (slope = 1.07, intercept = -0.12 mu gm(-3), R-2 = 0.76). Based on this study, organic species on average contributed 35% to the total water, with a substantially higher contribution (50 %) at night. However, not including contributions of organic water had a minor effect on pH (changes pH by 0.15 to 0.23 units), suggesting that predicted pH without consideration of organic water could be sufficient for the purposes of aqueous secondary organic aerosol (SOA) chemistry. The mean pH predicted in the Alabama forest (SOAS) was 0.94 +/- 0.59 (median 0.93). pH diurnal trends followed liquid water and were driven mainly by variability in RH; during SOAS nighttime pH was near 1.5, while daytime pH was near 0.5. pH ranged from 0.5 to 2 in summer and 1 to 3 in the winter at other sites. The systematically low pH levels in the southeast may have important ramifications, such as significantly influencing acid-catalyzed reactions, gas-aerosol partitioning, and mobilization of redox metals and minerals. Particle ion balances or molar ratios, often used to infer pH, do not consider the dissociation state of individual ions or particle liquid water levels and do not correlate with particle pH.
C1 [Guo, H.; Hite, J. R., Jr.; Bergin, M. H.; Ng, N. L.; Nenes, A.; Weber, R. J.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Xu, L.; Bougiatioti, A.; Cerully, K. M.; Ng, N. L.; Nenes, A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Bergin, M. H.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Capps, S. L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Lee, S. -H.] Kent State Univ, Coll Publ Hlth, Kent, OH 44242 USA.
[Nenes, A.] Fdn Res & Technol, Hellas, Greece.
[Bougiatioti, A.] Natl Tech Univ Athens, Athens, Greece.
RP Weber, RJ (reprint author), Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
EM athanasios.nenes@gatech.edu; rodney.weber@eas.gatech.edu
RI Carlton, Annmarie/A-7867-2011; Capps, Shannon/E-5602-2017
OI Carlton, Annmarie/0000-0002-8574-1507; Capps,
Shannon/0000-0002-6872-6604
FU NSF as part of the SOAS campaign [1242258]; US EPA STAR [R835410]; NOAA
CPO [NA10OAR4310102]; EPA through US EPA [R834799]; Research
Participation Program at the Office of Research and Development, US EPA;
Georgia Power Faculty Scholar Chair; Georgia Institute of Technology;
NSF [AGS-1241498]; Operational Program "Education and Lifelong Learning"
(Action's Beneficiary: General Secretariat for Research and Technology);
European Social Fund (ESF); Greek state
FX This work was supported by the NSF under grant number 1242258 as part of
the SOAS campaign. GIT SOAS researchers were also supported by a US EPA
STAR grant R835410 and NOAA CPO Award NA10OAR4310102. Measurements at
other sites in the southeast were part of the EPA-supported SCAPE Clean
Air Center, made possible through US EPA grant R834799. The content of
this publication are solely the responsibility of the grantee and do not
necessarily represent the official views of the US EPA. Further, the US
EPA does not endorse the purchase of any commercial products or services
mentioned in the publication. S. L. Capps was supported by an
appointment to the Research Participation Program at the Office of
Research and Development, US EPA, administered by ORISE. A. Nenes
acknowledges support from a Georgia Power Faculty Scholar Chair and a
Cullen-Peck Faculty Fellowship from the Georgia Institute of Technology.
We would also like to thank Richard Moore from NASA Langley for valuable
suggestions and discussions. S.-H. Lee acknowledges funding support from
NSF (AGS-1241498). A. Bougiatioti acknowledges support within the
framework of the Action Supporting Postdoctoral Researchers of the
Operational Program "Education and Lifelong Learning" (Action's
Beneficiary: General Secretariat for Research and Technology) and is
co-financed by the European Social Fund (ESF) and the Greek state. We
wish to thank the Southeastern Aerosol Research and Characterization
(SEARCH) personnel for their many contributions supporting the field
deployments.
NR 82
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Z9 41
U1 25
U2 86
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 9
BP 5211
EP 5228
DI 10.5194/acp-15-5211-2015
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BL
UT WOS:000355289100015
ER
PT J
AU Baker, KR
Carlton, AG
Kleindienst, TE
Offenberg, JH
Beaver, MR
Gentner, DR
Goldstein, AH
Hayes, PL
Jimenez, JL
Gilman, JB
de Gouw, JA
Woody, MC
Pye, HOT
Kelly, JT
Lewandowski, M
Jaoui, M
Stevens, PS
Brune, WH
Lin, YH
Rubitschun, CL
Surratt, JD
AF Baker, K. R.
Carlton, A. G.
Kleindienst, T. E.
Offenberg, J. H.
Beaver, M. R.
Gentner, D. R.
Goldstein, A. H.
Hayes, P. L.
Jimenez, J. L.
Gilman, J. B.
de Gouw, J. A.
Woody, M. C.
Pye, H. O. T.
Kelly, J. T.
Lewandowski, M.
Jaoui, M.
Stevens, P. S.
Brune, W. H.
Lin, Y. -H.
Rubitschun, C. L.
Surratt, J. D.
TI Gas and aerosol carbon in California: comparison of measurements and
model predictions in Pasadena and Bakersfield
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; SAN-JOAQUIN VALLEY; LOS-ANGELES BASIN;
AIR-QUALITY; UNITED-STATES; SOA FORMATION; AGRICULTURAL CROPS;
OXALIC-ACID; 2010 CALNEX; EMISSIONS
AB Co-located measurements of fine particulate matter (PM2.5 /organic carbon (OC), elemental carbon, radiocarbon (C-14), speciated volatile organic compounds (VOCs), and OH radicals during the CalNex field campaign provide a unique opportunity to evaluate the Community Multi-scale Air Quality (CMAQ) model's representation of organic species from VOCs to particles. Episode average daily 23 h average C-14 analysis indicates PM2.5 carbon at Pasadena and Bakersfield during the CalNex field campaign was evenly split between contemporary and fossil origins. CMAQ predicts a higher contemporary carbon fraction than indicated by the C-14 analysis at both locations. The model underestimates measured PM2.5 organic carbon at both sites with very little (7% in Pasadena) of the modeled mass represented by secondary production, which contrasts with the ambient-based SOC / OC fraction of 63% at Pasadena.
Measurements and predictions of gas-phase anthropogenic species, such as toluene and xylenes, are generally within a factor of 2, but the corresponding SOC tracer (2,3-dihydroxy-4-oxo-pentanoic acid) is systematically underpredicted by more than a factor of 2. Monoterpene VOCs and SOCs are underestimated at both sites. Isoprene is underestimated at Pasadena and overpredicted at Bakersfield and isoprene SOC mass is underestimated at both sites. Systematic model underestimates in SOC mass coupled with reasonable skill (typically within a factor of 2) in predicting hydroxyl radical and VOC gas-phase precursors suggest error( s) in the parameterization of semivolatile gases to form SOC. Yield values (alpha) applied to semivolatile partitioning species were increased by a factor of 4 in CMAQ for a sensitivity simulation, taking into account recent findings of underestimated yields in chamber experiments due to gas wall losses. This sensitivity resulted in improved model performance for PM2.5 organic carbon at both field study locations and at routine monitor network sites in California. Modeled percent secondary contribution (22% at Pasadena) becomes closer to ambient-based estimates but still contains a higher primary fraction than observed.
C1 [Baker, K. R.; Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Kleindienst, T. E.; Offenberg, J. H.; Beaver, M. R.; Woody, M. C.; Pye, H. O. T.; Lewandowski, M.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Gentner, D. R.] Yale Univ, Dept Chem & Environm Engn, New Haven, CT USA.
[Goldstein, A. H.] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA.
[Hayes, P. L.] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada.
[Jimenez, J. L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Jimenez, J. L.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Gilman, J. B.; de Gouw, J. A.] Natl Ocean & Atmospher Adm, Chem Sci Div, Earth Syst Res Lab, Boulder, CO USA.
[Jaoui, M.] Alion Sci & Technol Inc, Res Triangle Pk, NC USA.
[Stevens, P. S.] Indiana Univ, Sch Publ & Environm Affairs, Ctr Res Environm Sci, Bloomington, IN USA.
[Stevens, P. S.] Indiana Univ, Dept Chem, Bloomington, IN USA.
[Brune, W. H.] Penn State Univ, Dept Meteorol, University Pk, PA 16802 USA.
[Lin, Y. -H.; Rubitschun, C. L.; Surratt, J. D.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
RP Baker, KR (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM baker.kirk@epa.gov
RI Kelly, James/F-8135-2010; Carlton, Annmarie/A-7867-2011; de Gouw,
Joost/A-9675-2008; Jimenez, Jose/A-5294-2008; Surratt,
Jason/D-3611-2009; Offenberg, John/C-3787-2009; Lin,
Ying-Hsuan/J-4023-2014; Gilman, Jessica/E-7751-2010; Pye,
Havala/F-5392-2012; Manager, CSD Publications/B-2789-2015
OI Kelly, James/0000-0001-6574-5714; Carlton, Annmarie/0000-0002-8574-1507;
de Gouw, Joost/0000-0002-0385-1826; Jimenez, Jose/0000-0001-6203-1847;
Surratt, Jason/0000-0002-6833-1450; Offenberg, John/0000-0002-0213-4024;
Lin, Ying-Hsuan/0000-0001-8904-1287; Gilman,
Jessica/0000-0002-7899-9948; Pye, Havala/0000-0002-2014-2140;
FU EPA, through its Office of Research and Development [EP-D-10-070]; EPA's
STAR program [RD83504101]; CARB [11-305]
FX The authors would like to acknowledge measurements taken by Scott
Scheller and the contribution from Chris Misenis, Allan Beidler, Chris
Allen, James Beidler, Heather Simon, and Rich Mason. EPA, through its
Office of Research and Development, funded and collaborated in the
research described here under contract EP-D-10-070 to Alion Science and
Technology. This work is supported in part through EPA's STAR program,
grant number RD83504101. P. L. Hayes and J. L. Jimenez were supported by
CARB 11-305.
NR 77
TC 9
Z9 9
U1 6
U2 51
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 9
BP 5243
EP 5258
DI 10.5194/acp-15-5243-2015
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BL
UT WOS:000355289100017
ER
PT J
AU DeVito, SC
Keenan, C
Lazarus, D
AF DeVito, Stephen C.
Keenan, Cheryl
Lazarus, Dana
TI Can pollutant release and transfer registers (PRTRs) be used to assess
implementation and effectiveness of green chemistry practices? A case
study involving the Toxics Release Inventory (TRI) and pharmaceutical
manufacturers
SO GREEN CHEMISTRY
LA English
DT Article
AB Pharmaceutical firms have reported that implementation of green chemistry practices in their manufacturing processes have significantly reduced the quantities of toxic chemicals they use, release to the environment, or otherwise manage as waste. Using the United States Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI) database and literature publications, we conducted research to assess this claim. Our analyses show that over the 2002 through 2011 timeframe the quantities of toxic chemicals reported annually by pharmaceutical manufacturing facilities to EPA's TRI Program as released to the environment or otherwise managed as waste have declined steadily and by more than 60%. The large reductions in the reported quantities are sector-wide, and it appears that factors such as outsourcing, production levels, regulations, shifts to other waste management practices, or TRI reporting characteristics by the larger pharmaceutical firms are not driving the decline. Our analyses, combined with the extensive evidence in the literature of green chemistry advances within the pharma sector, lead us to conclude that implementation of green chemistry practices is a major contributing factor to the large reductions we report herein. We believe the TRI, an easy-to-use pollution prevention tool used extensively for tracking environmental performance, is uniquely well-suited for assessing the progress made by different industry sectors or specific facilities therein in implementing green chemistry practices and the effectiveness that such practices have in preventing pollution: uses of the TRI that hitherto have not been reported. Moreover, our findings indicate that other pollutant release and transfer registers (PRTRs) may have the potential to be used for these purposes as well.
C1 [DeVito, Stephen C.] US EPA, Tox Release Inventory Program, Washington, DC 20460 USA.
[Keenan, Cheryl; Lazarus, Dana] Abt Associates Inc, Cambridge, MA 02138 USA.
RP DeVito, SC (reprint author), US EPA, Tox Release Inventory Program, Mail Code 2844 T, Washington, DC 20460 USA.
EM devito.steve@epa.gov
NR 34
TC 2
Z9 2
U1 3
U2 7
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 5
BP 2679
EP 2692
DI 10.1039/c5gc00056d
PG 14
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CI0EQ
UT WOS:000354409500006
ER
PT J
AU Cinelli, M
Coles, SR
Nadagouda, MN
Blaszczynski, J
Slowinski, R
Varma, RS
Kirwan, K
AF Cinelli, Marco
Coles, Stuart R.
Nadagouda, Mallikarjuna N.
Blaszczynski, Jerzy
Slowinski, Roman
Varma, Rajender S.
Kirwan, Kerry
TI A green chemistry-based classification model for the synthesis of silver
nanoparticles
SO GREEN CHEMISTRY
LA English
DT Article
ID LIFE-CYCLE ASSESSMENT; CRITERIA DECISION-ANALYSIS; ROUGH SET APPROACH;
MICROWAVE-ASSISTED SYNTHESIS; EX ANTE ASSESSMENT; METAL NANOPARTICLES;
ANTIBACTERIAL ACTIVITY; MULTICRITERIA CLASSIFICATION;
SONOELECTROCHEMICAL METHODS; CROPPING SYSTEMS
AB The assessment of the implementation of green chemistry principles in the syntheses of nanomaterials is a complex decision-making problem that necessitates the integration of several evaluation criteria. Multiple Criteria Decision Aiding (MCDA) provides support for such a challenge. One of its methods - Dominance-based Rough Set Approach (DRSA) - was used in this research to develop a model for the green chemistry-based classification of silver nanoparticle synthesis protocols into preference-ordered performance classes. DRSA allowed integration of knowledge from both peer-reviewed literature and experts (decision makers, DMs) in the field, resulting in a model composed of decision rules that are logical statements in the form: "if conditions, then decision". The approach provides the basis for the design of rules for the greener synthesis of silver nanoparticles. Decision rules are supported by synthesis protocols that enforce the principles of green chemistry to various extents, resulting in robust recommendations for the development and assessment of silver nanoparticle synthesis that perform at one of five pre-determined levels. The DRSA-based approach is transparent and structured and can be easily updated. New perspectives and criteria could be added into the model if relevant data were available and domain-specific experts could collaborate through the MCDA procedure.
C1 [Cinelli, Marco; Coles, Stuart R.; Kirwan, Kerry] Univ Warwick, Int Mfg Ctr, WMG, Coventry CV4 7AL, W Midlands, England.
[Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, NRMRL,ORD, Cincinnati, OH 45268 USA.
[Blaszczynski, Jerzy; Slowinski, Roman] Poznan Univ Tech, Inst Comp Sci, PL-60965 Poznan, Poland.
[Slowinski, Roman] Polish Acad Sci, Syst Res Inst, PL-01447 Warsaw, Poland.
[Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Cinelli, M (reprint author), Univ Warwick, Int Mfg Ctr, WMG, Univ Rd, Coventry CV4 7AL, W Midlands, England.
EM m.cinelli@warwick.ac.uk; Varma.rajender@epa.gov;
kerry.kirwan@warwick.ac.uk
RI Slowinski, Roman/A-5751-2013; Blaszczynski, Jerzy/M-1601-2014;
OI Slowinski, Roman/0000-0002-5200-7795; Cinelli, Marco/0000-0001-5822-3627
FU UK Engineering and Physical Sciences Research Council; WMG Department of
the University of Warwick (UK); "CL4W", Cleaning Land for Wealth
[EP/K026216/1]
FX The authors greatly acknowledge the funding from the UK Engineering and
Physical Sciences Research Council, WMG Department of the University of
Warwick (UK) and the "CL4W", Cleaning Land for Wealth, project (grant
number EP/K026216/1). The authors would like to thank Dr David E. Meyer,
Dr Michael Gonzalez and Dr Gerardo Ruiz-Mercado from U.S. EPA for the
thorough and constructive feedback provided during the paper
development.
NR 121
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U2 24
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 5
BP 2825
EP 2839
DI 10.1039/c4gc02088j
PG 15
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CI0EQ
UT WOS:000354409500027
ER
PT J
AU Chern, EC
King, D
Haugland, R
Pfaller, S
AF Chern, Eunice C.
King, Dawn
Haugland, Richard
Pfaller, Stacy
TI Evaluation of quantitative polymerase chain reaction assays targeting
Mycobacterium avium, M. intracellulare, and M. avium subspecies
paratuberculosis in drinking water biofilms
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE biofilm; M. avium; M. avium subsp paratuberculosis; M. intracellulare;
qPCR
ID REAL-TIME PCR; NONTUBERCULOUS MYCOBACTERIA; ENVIRONMENTAL MYCOBACTERIA;
DISTRIBUTION-SYSTEMS; POTABLE WATER; COMPLEX; INFECTION; SAMPLES;
QUANTIFICATION; IDENTIFICATION
AB Mycobacterium avium (MA), Mycobacterium intracellulare (MI), and Mycobacterium avium subsp. paratuberculosis (MAP) are difficult to culture due to their slow growing nature. A quantitative polymerase chain reaction (qPCR) method for the rapid detection of MA, MI, and MAP can be used to provide data supporting drinking water biofilms as potential sources of human exposure. The aim of this study was to characterize two qPCR assays targeting partial 16S rRNA gene sequences of MA and MI and use these assays, along with two previously reported MAP qPCR assays (IS900 and Target 251), to investigate Mycobacterium occurrence in kitchen faucet biofilms. MA and MI qPCR assays demonstrated 100% specificity and sensitivity when evaluated against 18 non-MA complex, 76 MA, and 17 MI isolates. Both assays detected approximately 1,000 cells from a diluted cell stock inoculated on a sampling swab 100% of the time. DNA analysis by qPCR indicated that 35.3, 56.9 and 11.8% of the 51 kitchen faucet biofilm samples collected contained MA, MI, and MAP, respectively. This study introduces novel qPCR assays designed to specifically detect MA and MI in biofilm. Results support the use of qPCR as an alternative to culture for detection and enumeration of MA, MI, and MAP in microbiologically complex samples.
C1 [Chern, Eunice C.; King, Dawn; Haugland, Richard; Pfaller, Stacy] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Pfaller, S (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM pfaller.stacy@epa.gov
FU US EPA, ORD
FX The authors wish to thank all individuals that provided samples for this
study. The views expressed in this article are those of the authors and
do not necessarily represent the views or policies of the US
Environmental Protection Agency. Mention of trade names, products or
services does not convey official EPA approval, endorsement, or
recommendation. This project was supported in part by an appointment to
the Research Participation Program for the US EPA, ORD, administered by
the Oak Ridge Institute for Science and Education through an interagency
agreement between the US DOE and the EPA.
NR 37
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U1 6
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 1
BP 131
EP 139
DI 10.2166/wh.2014.060
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CJ0QY
UT WOS:000355183800013
PM 25719473
ER
PT J
AU Gomez-Alvarez, V
Humrighouse, BW
Revetta, RP
Domingo, JWS
AF Gomez-Alvarez, Vicente
Humrighouse, Ben W.
Revetta, Randy P.
Domingo, Jorge W. Santo
TI Bacterial composition in a metropolitan drinking water distribution
system utilizing different source waters
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE bacterial diversity; drinking water bacteria; 16S rRNA gene sequencing
ID COMMUNITY STRUCTURE; BIOFILMS; MYCOBACTERIA; ECOLOGY; CHLORINATION;
DIVERSITY; PROTOZOA; RNA
AB We investigated the bacterial composition of water samples from two service areas within a drinking water distribution system (DWDS), each associated with a different primary source of water (groundwater, GW; surface water, SW) and different treatment process. Community analysis based on 16S rRNA gene clone libraries indicated that Actinobacteria (Mycobacterium spp.) and alpha-Proteobacteria represented nearly 43 and 38% of the total sequences, respectively. Sequences closely related to Legionella, Pseudomonas, and Vibrio spp. were also identified. In spite of the high number of sequences (71%) shared in both areas, multivariable analysis revealed significant differences between the GW and SW areas. While the dominant phylotypes where not significantly contributing in the ordination of samples, the populations associated with the core of phylotypes (1-10% in each sample) significantly contributed to the differences between both service areas. Diversity indices indicate that the microbial community inhabiting the SW area is more diverse and contains more distantly related species coexisting with local assemblages as compared with the GW area. The bacterial community structure of SW and GW service areas were dissimilar, suggesting that their respective source water and/or water quality parameters shaped by the treatment processes may contribute to the differences in community structure observed.
C1 [Gomez-Alvarez, Vicente; Revetta, Randy P.; Domingo, Jorge W. Santo] US EPA, Cincinnati, OH 45268 USA.
[Humrighouse, Ben W.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH USA.
[Humrighouse, Ben W.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Domingo, JWS (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM santodomingo.jorge@epa.gov
FU US Environmental Protection Agency
FX This work was funded by a Traineeship Award from the US Environmental
Protection Agency to BWH. Special thanks to Jeff Swertfeger from the
Greater Cincinnati Water Work (GCWW) for helping in the logistics of the
water collection, to the Greater Cincinnati Water Work personnel for
helping in the water collection and Margaret Kupferle and Daniel Oerther
for revising initial drafts of this manuscript. The opinions expressed
in this paper are those of the authors, and do not necessarily reflect
the official positions and policies of the US Environmental Protection
Agency. Any mention of product or trade names does not constitute
recommendation for use by the US Environmental Protection Agency.
NR 37
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 1
BP 140
EP 151
DI 10.2166/wh.2014.057
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CJ0QY
UT WOS:000355183800014
PM 25719474
ER
PT J
AU Rahman, L
Shah, A
Lunsford, SK
Han, C
Nadagouda, MN
Sahle-Demessie, E
Qureshi, R
Khan, MS
Kraatz, HB
Dionysiou, DD
AF Rahman, Latif-ur
Shah, Afzal
Lunsford, Suzanne Kay
Han, Changseok
Nadagouda, Mallikarjuna N.
Sahle-Demessie, Endalkachew
Qureshi, Rumana
Khan, Muhammad Saleem
Kraatz, Heinz-Bernhard
Dionysiou, Dionysios. D.
TI Monitoring of 2-butanone using a Ag-Cu bimetallic alloy nanoscale
electrochemical sensor
SO RSC ADVANCES
LA English
DT Article
ID AU-AG; DNA HYBRIDIZATION; NANOPARTICLES; OXIDATION
AB Spherical shaped silver-copper alloy nanoparticles of 10-15 nm size were synthesized by an aqueous polymer solution method. The synthesized nanoscale Ag-Cu alloy was characterized by UV-Visible spectroscopy, X-ray diffraction spectroscopy, transmission electron microscopy (TEM), high resolution TEM, and energy dispersive spectroscopy. The XRD pattern showed high crystallinity and phase formation of the nanoparticles. The bimetallic alloy nanoparticles were coated over a well-polished glassy carbon electrode and the designed sensor was applied for the detection of a highly carcinogenic carbonyl compound, 2-butanone. Electrochemical studies revealed that PEI used as a capping agent also enhances the sensing of the modified electrode for the recognition of 2-butanone. The sensor developed from Ag-Cu (1 : 1) alloy nanoparticles showed the best sensing properties for the detection of 2-butanone as evidenced by electrochemical impedance spectroscopy and a 0.1 mu M detection limit.
C1 [Rahman, Latif-ur; Shah, Afzal; Qureshi, Rumana] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
[Rahman, Latif-ur; Han, Changseok; Dionysiou, Dionysios. D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[Kraatz, Heinz-Bernhard] Univ Toronto, Dept Phys & Environm Sci, Toronto, ON M1C 1A4, Canada.
[Lunsford, Suzanne Kay] Wright State Univ, Dept Chem, Dayton, OH 45435 USA.
[Han, Changseok; Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Water Qual Management Branch, Cincinnati, OH 45268 USA.
[Sahle-Demessie, Endalkachew] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
[Khan, Muhammad Saleem] Univ Peshawar, Natl Ctr Excellence Phys Chem, Khyber Pakhtunkhwa, Pakistan.
RP Shah, A (reprint author), Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
EM afzal.shah@utoronto.ca; dionysios.d.dionysiou@uc.edu
RI Shah, Afzal/J-2242-2015;
OI Kraatz, Bernie/0000-0002-7149-0110
FU Chemistry Department of Quaid-i-Azam University, Islamabad, Pakistan;
Department of Physical and Environmental Sciences, University of
Toronto, Canada; Department of Biomedical, Chemical and Environmental
Engineering (DBCEE), University of Cincinnati, Cincinnati, Ohio, USA;
Higher Education Commission of Pakistan
FX This work was jointly supported by the Chemistry Department of
Quaid-i-Azam University, Islamabad, Pakistan, Department of Physical and
Environmental Sciences, University of Toronto, Canada and Department of
Biomedical, Chemical and Environmental Engineering (DBCEE), University
of Cincinnati, Cincinnati, Ohio, USA. The financial support of Higher
Education Commission of Pakistan is also acknowledged.
NR 32
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U2 17
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 55
BP 44427
EP 44434
DI 10.1039/c5ra03633j
PG 8
WC Chemistry, Multidisciplinary
SC Chemistry
GA CI7SM
UT WOS:000354964900063
ER
PT S
AU Brown-Peterson, NJ
Brewton, RA
Griffitt, RJ
Fulford, RS
AF Brown-Peterson, Nancy J.
Brewton, Rachel A.
Griffitt, Robert J.
Fulford, Richard S.
BE Alford, JB
Peterson, MS
Green, CC
TI Impacts of the Deepwater Horizon Oil Spill on the Reproductive Biology
of Spotted Seatrout (Cynoscion nebulosus)
SO IMPACTS OF OIL SPILL DISASTERS ON MARINE HABITATS AND FISHERIES IN NORTH
AMERICA
SE CRC Marine Biology Series
LA English
DT Article; Book Chapter
ID GULF-OF-MEXICO; LOUISIANA SALT MARSHES; FISH; ESTUARIES; GROWTH
C1 [Brown-Peterson, Nancy J.; Griffitt, Robert J.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA.
[Brewton, Rachel A.] Texas A&M Univ Corpus Christi, Harte Res Inst Gulf Mexico Studies, Corpus Christi, TX USA.
[Fulford, Richard S.] US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL USA.
RP Brown-Peterson, NJ (reprint author), Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA.
NR 27
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U1 2
U2 7
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
SN 2154-7769
BN 978-1-4665-5721-5; 978-1-4665-5720-8
J9 CRC MAR BIOL SER
JI CRC Mar. Biol. Ser.
PY 2015
BP 237
EP 252
PG 16
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA BC7CH
UT WOS:000354736900013
ER
PT S
AU Fulford, RS
Griffit, RJ
Brown-Peterson, NJ
Perry, H
Sanchez-Rubio, G
AF Fulford, Richard S.
Griffit, Robert J.
Brown-Peterson, Nancy J.
Perry, Harriet
Sanchez-Rubio, Guillermo
BE Alford, JB
Peterson, MS
Green, CC
TI Impacts of the Deepwater Horizon Oil Spill on Blue Crab, Callinectes
sapidus, Larval Settlement in Mississippi
SO IMPACTS OF OIL SPILL DISASTERS ON MARINE HABITATS AND FISHERIES IN NORTH
AMERICA
SE CRC Marine Biology Series
LA English
DT Article; Book Chapter
ID PRINCE-WILLIAM-SOUND; GULF-OF-MEXICO; CHESAPEAKE BAY; ALASKA; ABUNDANCE;
USA; VARIABILITY; RECRUITMENT; ENVIRONMENT; DISPERSION
C1 [Fulford, Richard S.] US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL 32561 USA.
[Griffit, Robert J.; Brown-Peterson, Nancy J.; Perry, Harriet] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA.
[Sanchez-Rubio, Guillermo] Ctr Fisheries Res & Dev, Gulf Coast Res Lab, Ocean Springs, MS USA.
RP Fulford, RS (reprint author), US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL 32561 USA.
NR 35
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U1 1
U2 7
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
SN 2154-7769
BN 978-1-4665-5721-5; 978-1-4665-5720-8
J9 CRC MAR BIOL SER
JI CRC Mar. Biol. Ser.
PY 2015
BP 253
EP 267
PG 15
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA BC7CH
UT WOS:000354736900014
ER
PT J
AU Duckworth, K
Spencer, M
Bates, C
Miller, ME
Almquist, C
Grimaila, M
Magnuson, M
Willison, S
Phillips, R
Racz, L
AF Duckworth, Kelsey
Spencer, Michael
Bates, Christopher
Miller, Michael E.
Almquist, Catherine
Grimaila, Michael
Magnuson, Matthew
Willison, Stuart
Phillips, Rebecca
Racz, LeeAnn
TI Advanced oxidation degradation kinetics as a function of ultraviolet LED
duty cycle
SO WATER SCIENCE AND TECHNOLOGY
LA English
DT Article
DE hydrogen peroxide; light emitting diode; methylene blue; ultraviolet
ID LIGHT EMITTING DIODES; AQUEOUS-SOLUTION; UV; EFFICIENCY; ILLUMINATION;
PHENOL
AB Ultraviolet (UV) light emitting diodes (LEDs) may be a viable option as a UV light source for advanced oxidation processes (AOPs) utilizing photocatalysts or oxidizing agents such as hydrogen peroxide. The effect of UV-LED duty cycle, expressed as the percentage of time the LED is powered, was investigated in an AOP with hydrogen peroxide, using methylene blue (MB) to assess contaminant degradation. The UV-LED AOP degraded the MB at all duty cycles. However, adsorption of MB onto the LED emitting surface caused a linear decline in reactor performance over time. With regard to the effect of duty cycle, the observed rate constant of MB degradation, after being adjusted to account for the duty cycle, was greater for 5 and 10% duty cycles than higher duty cycles, providing a value approximately 160% higher at 5% duty cycle than continuous operation. This increase in adjusted rate constant at low duty cycles, as well as contaminant fouling of the LED surface, may impact design and operational considerations for pulsed UV-LED AOP systems.
C1 [Duckworth, Kelsey; Spencer, Michael; Bates, Christopher; Miller, Michael E.; Grimaila, Michael; Racz, LeeAnn] Air Force Inst Technol, Dept Syst Engn & Management, Wright Patterson AFB, OH 45433 USA.
[Almquist, Catherine] Miami Univ, Chem Paper & Biomed Engn Dept, Oxford, OH 45056 USA.
[Magnuson, Matthew; Willison, Stuart] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
[Phillips, Rebecca] US EPA, Oak Ridge Inst Sci & Educ, Cincinnati, OH 45268 USA.
RP Miller, ME (reprint author), Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA.
EM michael.miller@afit.edu
FU US Environmental Protection Agency through Office of Research and
Development [92370201]; appointment to the Internship/Research
Participation Program at the National Homeland Security Research Center,
Water Infrastructure Protection Division, US Environmental Protection
Agency
FX The US Environmental Protection Agency through its Office of Research
and Development partially funded and collaborated in the research
described here under Interagency Agreement 92370201. It has been
subjected to the Agency's review and approved for publication. Approval
does not signify that the contents necessarily reflect the views of the
Agency. Mention of trade names, products, or services does not convey
official EPA approval, endorsement, or recommendation. This project was
supported in part by an appointment to the Internship/Research
Participation Program at the National Homeland Security Research Center,
Water Infrastructure Protection Division, US Environmental Protection
Agency, administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy and EPA. The authors would like to acknowledge the support of
Sarah Fyda, Nate Godby and Robert Scott for collecting a portion of the
experimental data.
NR 19
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0273-1223
EI 1996-9732
J9 WATER SCI TECHNOL
JI Water Sci. Technol.
PY 2015
VL 71
IS 9
BP 1375
EP 1381
DI 10.2166/wst.2015.108
PG 7
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA CI4NF
UT WOS:000354726000014
PM 25945855
ER
PT J
AU McAlary, T
Groenevelt, H
Disher, S
Arnold, J
Seethapathy, S
Sacco, P
Crump, D
Schumacher, B
Hayes, H
Johnson, P
Gorecki, T
AF McAlary, Todd
Groenevelt, Hester
Disher, Stephen
Arnold, Jason
Seethapathy, Suresh
Sacco, Paolo
Crump, Derrick
Schumacher, Brian
Hayes, Heidi
Johnson, Paul
Gorecki, Tadeusz
TI Passive sampling for volatile organic compounds in indoor air-controlled
laboratory comparison of four sampler types
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID DIFFUSIVE SAMPLER; THERMAL-DESORPTION; VAPOR INTRUSION;
ENVIRONMENTAL-ANALYSIS; AMBIENT AIR; NEW-YORK; EXPOSURE; SOLVENT;
DEVICE; VOCS
AB This article describes laboratory testing of four passive diffusive samplers for assessing indoor air concentrations of volatile organic compounds (VOCs), including SKC Ultra II, Radiello (R), Waterloo Membrane Sampler (WMS) and Automated Thermal Desorption (ATD) tubes with two different sorbents (Tenax TA and Carbopack B). The testing included 10 VOCs (including chlorinated ethenes, ethanes, and methanes, aromatic and aliphatic hydrocarbons), spanning a range of properties and including some compounds expected to pose challenges (naphthalene, methyl ethyl ketone). Tests were conducted at different temperatures (17 to 30 degrees C), relative humidities (30 to 90% RH), face velocities (0.014 to 0.41 ms(-1)), concentrations (1 to 100 parts per billion by volume [ppb(v)]) and sampling durations (1 to 7 days). The results show that all of the passive samplers provided data that met the success criteria (relative percent difference [RPD] <= 45% of active sample concentrations and coefficient of variation [COV] <= 30%) in the majority of cases, but some compounds were problematic for some samplers. The passive sampler uptake rates depend to varying degrees on the sampler, sorbent, target compounds and environmental conditions, so field calibration is advantageous for the highest levels of data quality.
C1 [McAlary, Todd; Groenevelt, Hester] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Eurofins Air Tox Inc, Air Tox Ltd, Folsom, CA USA.
[McAlary, Todd; Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy.
[Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England.
[Schumacher, Brian] US EPA, Las Vegas, NV 89193 USA.
[Johnson, Paul] Arizona State Univ, Tempe, AZ USA.
RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane,2, Guelph, ON N1G 5G3, Canada.
EM tmcalary@geosyntec.com
OI Gorecki, Tadeusz/0000-0001-7727-7516
FU Environmental Security Technology Certification Program (ESTCP)
FX Funding was provided by the Environmental Security Technology
Certification Program (ESTCP). Dr Samuel Brock of the Air Force Civil
Engineering Center (AFCEC) was the Department of Defense (DoD) Liaison
and Andrea Leeson of ESTCP was the Contracting Officer's Representative.
The experimental design was developed with the assistance of Brian
Schumacher and John Nocerino of EPA Research Labs in Las Vegas. We also
gratefully acknowledge Catarina Boaretto of the Fondazione Salitore
Maugeri for GC/MS analysis of the Radiello samplers. The study team
included individuals with interests in the various passive samplers (as
described in the ESI dagger), but the study design, results and
interpretation were reviewed by all coauthors and mutually considered to
provide a fair and unbiased comparison.
NR 78
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U2 28
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 5
BP 896
EP 905
DI 10.1039/c4em00560k
PG 10
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CI0FM
UT WOS:000354412100001
PM 25861049
ER
PT J
AU Schenck, K
Rosenblum, L
Ramakrishnan, B
Carson, J
Macke, D
Nietch, C
AF Schenck, Kathleen
Rosenblum, Laura
Ramakrishnan, Balaji
Carson, John, Jr.
Macke, Dana
Nietch, Christopher
TI Correlation of trace contaminants to wastewater management practices in
small watersheds
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID SURFACE WATERS; ANTIBIOTIC SULFAMETHOXAZOLE; SWEETENER SUCRALOSE;
ORGANIC-COMPOUNDS; SEWAGE-TREATMENT; TREATMENT-PLANT; DRINKING-WATER;
SEPTIC SYSTEM; PHARMACEUTICALS; FATE
AB Ten low-order streams draining headwater catchments within the East Fork Little Miami Watershed were evaluated throughout one year for the presence of six steroidal hormones, the antibiotic sulfamethoxazole, the antimicrobials triclosan and triclocarban, and the artificial sweetener sucralose. The wastewater management practices in the catchments included septic systems, sanitary sewers, a combination of both, and a parkland with no treatment systems. The concentrations and detection frequencies of sucralose showed a significant positive correlation with the septic density in each catchment. A similar relationship was found for sulfamethoxazole. Both sucralose and sulfamethoxazole are hydrophilic and unlikely to be removed effectively by sorption during septic treatment. The concentrations and detection frequencies of the antimicrobials were also positively correlated with septic density. The presence of the antimicrobials in the streams indicates that although they are hydrophobic, removal during septic treatment was incomplete. The target analytes that correlated with septic density were also detected in stream samples collected below a wastewater treatment plant located within the same watershed. The steroidal hormone estrone was the most frequently detected analyte at all sites. However, the estrone concentrations and detection frequencies did not correlate with the septic density due to multiple non-point sources.
C1 [Schenck, Kathleen; Macke, Dana; Nietch, Christopher] US EPA, Cincinnati, OH 45268 USA.
[Rosenblum, Laura; Ramakrishnan, Balaji] CB&I Fed Serv, Cincinnati, OH 45268 USA.
[Carson, John, Jr.] CB&I Fed Serv LLC, Findlay, OH 45840 USA.
RP Schenck, K (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM schenck.kathleen@epa.gov
FU U.S. Environmental Protection Agency
FX We thank the Clermont County Office of Environmental Quality for access
to geographic information system septic and sewer data. The U.S.
Environmental Protection Agency, through its Office of Research and
Development, funded and managed the research described herein. It has
been subjected to the Agency's peer and administrative review and has
been approved for external publication. Any opinions expressed in this
paper are those of the author(s) and do not necessarily reflect the
official positions and policies of the U.S. EPA. Any mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 51
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U1 5
U2 20
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 5
BP 956
EP 964
DI 10.1039/c4em00583j
PG 9
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CI0FM
UT WOS:000354412100008
PM 25881834
ER
PT J
AU Martins, I
Sanches, B
Kaufmann, PR
Hughes, RM
Santos, GB
Molozzi, J
Callisto, M
AF Martins, Isabela
Sanches, Barbara
Kaufmann, Philip Robert
Hughes, Robert M.
Santos, Gilmar Bastos
Molozzi, Joseline
Callisto, Marcos
TI Ecological assessment of a southeastern Brazil reservoir
SO BIOTA NEOTROPICA
LA English
DT Article
DE reservoirs; water quality; bioindicators; physical habitat;
environmental quality
ID BENTHIC MACROINVERTEBRATES; COMMUNITY STRUCTURE; PHYSICAL HABITAT; FISH
ASSEMBLAGES; MINAS-GERAIS; RIVER-BASIN; DIVERSITY; PATTERNS; STREAM;
LAKES
AB Reservoirs are artificial ecosystems with multiple functions having direct and indirect benefits to humans; however, they also cause ecological changes and influence the composition and structure of aquatic biota. Our objectives were to: (1) assess the environmental condition of Nova Ponte Reservoir, Minas Gerais state, southeastern Brazil; and (2) determine how the aquatic biota respond to disturbances. A total of 40 sites in the littoral zone of the reservoir were sampled to characterize physical and chemical habitat, land use, and benthic macroinvertebrate and fish assemblages. The predominant type of land cover near the reservoir was natural vegetation. A total of 29 fish species and 39 macroinvertebrate taxa were collected, including eight alien species. Most sites had intermediate levels of human disturbance, however, high levels of degradation were associated with high proportions of alien species. Disturbances at multiple scales may alter natural patterns and processes, leading to environmental changes and damaging biological communities. Our results reinforce the importance of assessing reservoir ecological conditions at several scales. The study of land use, littoral zone physical habitat characteristics, water quality, and assemblage structure set the ground for proposing actions to rehabilitate and conserve aquatic ecosystems.
C1 [Martins, Isabela; Callisto, Marcos] Univ Fed Minas Gerais, Dept Biol Geral, Belo Horizonte, MG, Brazil.
[Sanches, Barbara; Santos, Gilmar Bastos] Pontificia Univ Catolica Minas Gerais, Programa Posgrad Zool Vertebrados, Belo Horizonte, MG, Brazil.
[Kaufmann, Philip Robert] US EPA, Western Ecol Div, Corvallis, OR USA.
[Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97331 USA.
[Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Molozzi, Joseline] Univ Estadual Paraiba, Dept Biol Geral, Campina Grande, PB, Brazil.
RP Callisto, M (reprint author), Univ Fed Minas Gerais, Dept Biol Geral, Belo Horizonte, MG, Brazil.
EM mcallisto13@gmail.com
RI Molozzi, Joseline/M-3951-2014; Callisto, Marcos/O-4930-2015
OI Callisto, Marcos/0000-0003-2341-4700
FU P&DANEEL (Projeto de Pesquisa e Desenvolvimento da Agencia Nacional de
Energia Eletrica) [GT-487]; CEMIG(Companhia Energetica de Minas Gerais)
- Programa Peixe Vivo; CAPES (Coordenacao de Aperfeicoamento de Pessoal
de Nivel Superior); CNPq (Conselho Nacional de Desenvolvimento
Cientifico e Tecnologico); FAPEMIG (Fundacao de Amparo a Pesquisa do
estado de Minas Gerais); PROGRAD/UFMG (Pro-Reitoria de Graduacao da
Universidade Federal de Minas Gerais); CNPq [302960/2011-2]; Minas
Gerais researcher grant FAPEMIG [PPM-00077/13]
FX The authors acknowledge P&DANEEL (GT-487) (Projeto de Pesquisa e
Desenvolvimento da Agencia Nacional de Energia Eletrica) and
CEMIG(Companhia Energetica de Minas Gerais) - Programa Peixe Vivo for
funding the project, CAPES (Coordenacao de Aperfeicoamento de Pessoal de
Nivel Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico), FAPEMIG (Fundacao de Amparo a Pesquisa do estado de Minas
Gerais) and PROGRAD/UFMG (Pro-Reitoria de Graduacao da Universidade
Federal de Minas Gerais) for financial support. Special thanks to
colleagues from the Laboratorio de Ecologia de Bentos - UFMG. MC was
awarded research productivity grant CNPq No. 302960/2011-2) and Minas
Gerais researcher grant FAPEMIG PPM-00077/13. Reviews by Bianca Terra
and 2 anonymous referees improved the manuscript. This manuscript was
subjected to review by the National Health and Environmental Effects
Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency.
NR 78
TC 0
Z9 0
U1 2
U2 36
PU REVISTA BIOTA NEOTROPICA
PI CAMPINAS
PA AV. DR. ROMEU TORTIMA, 388 - BARAO GERALDO, CEP 13084-520, CAMPINAS, SP,
BRAZIL
SN 1676-0603
J9 BIOTA NEOTROP
JI Biota Neotrop.
PY 2015
VL 15
IS 1
DI 10.1590/1676-06032015006114
PG 10
WC Biodiversity Conservation
SC Biodiversity & Conservation
GA CH5EQ
UT WOS:000354058300007
ER
PT J
AU Wong, DC
Yang, CE
Fu, JS
Wong, K
Gao, Y
AF Wong, D. C.
Yang, C. E.
Fu, J. S.
Wong, K.
Gao, Y.
TI An approach to enhance pnetCDF performance in environmental modeling
applications
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SYSTEM; EMISSION; OZONE
AB Data intensive simulations are often limited by their I/O (input/output) performance, and "novel" techniques need to be developed in order to overcome this limitation. The software package pnetCDF (parallel network Common Data Form), which works with parallel file systems, was developed to address this issue by providing parallel I/O capability. This study examines the performance of an application-level data aggregation approach which performs data aggregation along either row or column dimension of MPI (Message Passing Interface) processes on a spatially decomposed domain, and then applies the pnetCDF parallel I/O paradigm. The test was done with three different domain sizes which represent small, moderately large, and large data domains, using a small-scale Community Multiscale Air Quality model (CMAQ) mock-up code. The examination includes comparing I/O performance with traditional serial I/O technique, straight application of pnetCDF, and the data aggregation along row and column dimension before applying pnetCDF. After the comparison, "optimal" I/O configurations of this application-level data aggregation approach were quantified. Data aggregation along the row dimension (pnetCDFcr) works better than along the column dimension (pnetCDFcc) although it may perform slightly worse than the straight pnetCDF method with a small number of processors. When the number of processors becomes larger, pnetCDFcr outperforms pnetCDF significantly. If the number of processors keeps increasing, pnetCDF reaches a point where the performance is even worse than the serial I/O technique. This new technique has also been tested for a real application where it performs two times better than the straight pnetCDF paradigm.
C1 [Wong, D. C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Yang, C. E.; Fu, J. S.; Wong, K.; Gao, Y.] Univ Tennessee, Knoxville, TN USA.
RP Wong, DC (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM wong.david-c@epa.gov
OI Yang, Cheng-En/0000-0002-4069-4997
FU Office of Science of the US Department of Energy as part of the Regional
and Global Climate Modeling Program; DOE [DE-AC05-76RL01830]; National
Institute for Computational Sciences (NICS) [TG-ATM110009, UT-TENN0006]
FX Yang Gao was partly supported by the Office of Science of the US
Department of Energy as part of the Regional and Global Climate Modeling
Program. The Pacific Northwest National Laboratory is operated for DOE
by the Battelle Memorial Institute (DE-AC05-76RL01830). The Kraken is a
supercomputing facility through National Science Foundation TeraGrid
resources provided by the National Institute for Computational Sciences
(NICS) under grant numbers TG-ATM110009 and UT-TENN0006.
NR 17
TC 0
Z9 0
U1 0
U2 2
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 4
BP 1033
EP 1046
DI 10.5194/gmd-8-1033-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CH2FT
UT WOS:000353841800005
ER
PT J
AU Mallard, MS
Nolte, CG
Spero, TL
Bullock, OR
Alapaty, K
Herwehe, JA
Gula, J
Bowden, JH
AF Mallard, M. S.
Nolte, C. G.
Spero, T. L.
Bullock, O. R.
Alapaty, K.
Herwehe, J. A.
Gula, J.
Bowden, J. H.
TI Technical challenges and solutions in representing lakes when using WRF
in downscaling applications
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID REGIONAL CLIMATE MODEL; LAURENTIAN GREAT-LAKES; EFFECT SNOWFALL; ICE
COVER; SALT-LAKE; SIMULATION; SENSITIVITY; SYSTEM; IMPLEMENTATION;
PRECIPITATION
AB The Weather Research and Forecasting (WRF) model is commonly used to make high-resolution future projections of regional climate by downscaling global climate model (GCM) outputs. Because the GCM fields are typically at a much coarser spatial resolution than the target regional downscaled fields, lakes are often poorly resolved in the driving global fields, if they are resolved at all. In such an application, using WRF's default interpolation methods can result in unrealistic lake temperatures and ice cover at inland water points. Prior studies have shown that lake temperatures and ice cover impact the simulation of other surface variables, such as air temperatures and precipitation, two fields that are often used in regional climate applications to understand the impacts of climate change on human health and the environment. Here, alternative methods for setting lake surface variables in WRF for downscaling simulations are presented and contrasted.
C1 [Mallard, M. S.; Nolte, C. G.; Spero, T. L.; Bullock, O. R.; Alapaty, K.; Herwehe, J. A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Gula, J.] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA.
[Mallard, M. S.; Bowden, J. H.] Univ N Carolina, Inst Environm, Chapel Hill, NC 27514 USA.
RP Mallard, MS (reprint author), Univ N Carolina, Inst Environm, Chapel Hill, NC 27514 USA.
EM mmallard@email.unc.edu
RI Nolte, Christopher/H-4345-2012; Gula, Jonathan/J-9925-2012;
OI Nolte, Christopher/0000-0001-5224-9965; Gula,
Jonathan/0000-0002-0876-9557; Spero, Tanya/0000-0002-1600-0422
FU National Science Foundation
FX The lead author was supported by an appointment to the Research
Participation Program at the US Environmental Protection Agency (EPA)
Office of Research and Development, administered by the Oak Ridge
Institute for Science and Education (ORISE). The WRF model is made
available by NCAR, funded by the National Science Foundation. Great
Lakes ice cover data were obtained from GLERL
(http://www.glerl.noaa.gov/data/pgs/glice/glice.html). This research has
been subjected to the US EPA's administrative review and approved for
publication. The views expressed and the contents are solely the
responsibility of the authors and do not necessarily represent the
official views of the US EPA.
NR 55
TC 4
Z9 4
U1 0
U2 7
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 4
BP 1085
EP 1096
DI 10.5194/gmd-8-1085-2015
PG 12
WC Geosciences, Multidisciplinary
SC Geology
GA CH2FT
UT WOS:000353841800008
ER
PT J
AU Mage, DT
AF Mage, David T.
TI Comment on Schwartz, J.; Dockery, DW; Neas, ML 1996. Is daily mortality
associated specifically with fine particles?; J. Air Waste Manage.
Assoc. 46: 927-939
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Letter
ID PARTICULATE MATTER; HUMAN EXPOSURE; POLLUTION
C1 [Mage, David T.] World Hlth Org, San Francisco, CA USA.
[Mage, David T.] US EPA, San Francisco, CA USA.
NR 18
TC 0
Z9 0
U1 1
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 511
EP 513
DI 10.1080/10962247.2015.1029812
PG 3
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100001
PM 25947308
ER
PT J
AU Jones, RR
Hogrefe, C
Fitzgerald, EF
Hwang, SA
Ozkaynak, H
Garcia, VC
Lin, S
AF Jones, Rena R.
Hogrefe, Christian
Fitzgerald, Edward F.
Hwang, Syni-An
Oezkaynak, Haluk
Garcia, Valerie C.
Lin, Shao
TI Respiratory hospitalizations in association with fine PM and its
components in New York State
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID EMERGENCY-DEPARTMENT VISITS; PARTICULATE AIR-POLLUTION; SHORT-TERM
ASSOCIATIONS; CASE-CROSSOVER; CARDIORESPIRATORY DISEASES; ADMISSIONS;
PM2.5; PARTICLES; ASTHMA; MODEL
AB Despite observed geographic and temporal variation in particulate matter (PM)-related health morbidities, only a small number of epidemiologic studies have evaluated the relation between PM2.5 chemical constituents and respiratory disease. Most assessments are limited by inadequate spatial and temporal resolution of ambient PM measurements and/or by their approaches to examine the role of specific PM components on health outcomes. In a case-crossover analysis using daily average ambient PM2.5 total mass and species estimates derived from the Community Multiscale Air Quality (CMAQ) model and available observations, we examined the association between the chemical components of PM (including elemental and organic carbon, sulfate, nitrate, ammonium, and other remaining) and respiratory hospitalizations in New York State. We evaluated relationships between levels (low, medium, high) of PM constituent mass fractions, and assessed modification of the PM2.5-hospitalization association via models stratified by mass fractions of both primary and secondary PM components. In our results, average daily PM2.5 concentrations in New York State were generally lower than the 24-hr average National Ambient Air Quality Standard (NAAQS). Year-round analyses showed statistically significant positive associations between respiratory hospitalizations and PM2.5 total mass, sulfate, nitrate, and ammonium concentrations at multiple exposure lags (0.5-2.0% per interquartile range [IQR] increase). Primarily in the summer months, the greatest associations with respiratory hospitalizations were observed per IQR increase in the secondary species sulfate and ammonium concentrations at lags of 1-4 days (1.0-2.0%). Although there were subtle differences in associations observed between mass fraction tertiles, there was no strong evidence to support modification of the PM2.5-respiratory disease association by a particular constituent. We conclude that ambient concentrations of PM2.5 and secondary aerosols including sulfate, ammonium, and nitrate were positively associated with respiratory hospitalizations, although patterns varied by season. Exposure to specific fine PM constituents is a plausible risk factor for respiratory hospitalization in New York State.Implications: The association between ambient concentrations of PM2.5 components has been evaluated in only a small number of epidemiologic studies with refined spatial and temporal scale data. In New York State, fine PM and several of its constituents, including sulfate, ammonium, and nitrate, were positively associated with respiratory hospitalizations. Results suggest that PM species relationships and their influence on respiratory endpoints are complex and season dependent. Additional work is needed to better understand the relative toxicity of PM species, and to further explore the role of co-pollutant relationships and exposure prediction error on observed PM-respiratory disease associations.
C1 [Jones, Rena R.; Hwang, Syni-An; Lin, Shao] New York State Dept Hlth, Ctr Environm Hlth, Albany, NY USA.
[Jones, Rena R.; Fitzgerald, Edward F.; Hwang, Syni-An; Lin, Shao] SUNY Albany, Sch Publ Hlth, Rensselaer, NY USA.
[Hogrefe, Christian; Oezkaynak, Haluk; Garcia, Valerie C.] US EPA, Raleigh, NC USA.
RP Jones, RR (reprint author), NCI, Occupat & Environm Epidemiol Branch, 6906 Med Ctr Dr Room 6E124, Rockville, MD 20850 USA.
EM rena.jones@nih.gov
OI Lin, Shao/0000-0002-5535-7504
NR 36
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Z9 6
U1 1
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 559
EP 569
DI 10.1080/10962247.2014.1001500
PG 11
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100007
PM 25947314
ER
PT J
AU Fann, N
Nolte, CG
Dolwick, P
Spero, TL
Brown, AC
Phillips, S
Anenberg, S
AF Fann, Neal
Nolte, Christopher G.
Dolwick, Patrick
Spero, Tanya L.
Brown, Amanda Curry
Phillips, Sharon
Anenberg, Susan
TI The geographic distribution and economic value of climate change-related
ozone health impacts in the United States in 2030
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID CMAQ MODELING SYSTEM; AIR-POLLUTION; AMBIENT OZONE; MORTALITY RISKS; US
CITIES; TEMPERATURE; METAANALYSIS; ASSOCIATION; COMMUNITIES; METEOROLOGY
AB In this United States-focused analysis we use outputs from two general circulation models (GCMs) driven by different greenhouse gas forcing scenarios as inputs to regional climate and chemical transport models to investigate potential changes in near-term U.S. air quality due to climate change. We conduct multiyear simulations to account for interannual variability and characterize the near-term influence of a changing climate on tropospheric ozone-related health impacts near the year 2030, which is a policy-relevant time frame that is subject to fewer uncertainties than other approaches employed in the literature. We adopt a 2030 emissions inventory that accounts for fully implementing anthropogenic emissions controls required by federal, state, and/or local policies, which is projected to strongly influence future ozone levels. We quantify a comprehensive suite of ozone-related mortality and morbidity impacts including emergency department visits, hospital admissions, acute respiratory symptoms, and lost school days, and estimate the economic value of these impacts. Both GCMs project average daily maximum temperature to increase by 1-4 degrees C and 1-5 ppb increases in daily 8-hr maximum ozone at 2030, though each climate scenario produces ozone levels that vary greatly over space and time. We estimate tens to thousands of additional ozone-related premature deaths and illnesses per year for these two scenarios and calculate an economic burden of these health outcomes of hundreds of millions to tens of billions of U.S. dollars (2010$).Implications:Near-term changes to the climate have the potential to greatly affect ground-level ozone. Using a 2030 emission inventory with regional climate fields downscaled from two general circulation models, we project mean temperature increases of 1 to 4 degrees C and climate-driven mean daily 8-hr maximum ozone increases of 1-5 ppb, though each climate scenario produces ozone levels that vary significantly over space and time. These increased ozone levels are estimated to result in tens to thousands of ozone-related premature deaths and illnesses per year and an economic burden of hundreds of millions to tens of billions of U.S. dollars (2010$).
C1 [Fann, Neal; Dolwick, Patrick; Brown, Amanda Curry; Phillips, Sharon] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Nolte, Christopher G.; Spero, Tanya L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Anenberg, Susan] US Chem Safety & Hazard Invest Board, Washington, DC USA.
RP Fann, N (reprint author), US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM fann.neal@epa.gov
RI Nolte, Christopher/H-4345-2012
OI Nolte, Christopher/0000-0001-5224-9965
NR 49
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Z9 12
U1 2
U2 26
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 570
EP 580
DI 10.1080/10962247.2014.996270
PG 11
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100008
PM 25947315
ER
PT J
AU Sorg, TJ
Wang, LL
Chen, ASC
AF Sorg, Thomas J.
Wang, Lili
Chen, Abraham S. C.
TI The costs of small drinking water systems removing arsenic from
groundwater
SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
LA English
DT Article
DE arsenic; drinking water; technology demonstration; treatment cost
AB The US Environmental Protection Agency (EPA) conducted an Arsenic Demonstration Program whereby the Agency purchased, installed, and evaluated the performance and cost of 50 small water arsenic removal treatment systems in the USA. A major goal of the program was to collect high-quality cost data (capital and operational and maintenance (O&M)) from the long-term operation (1-4 years) of these systems. The technologies consisted of adsorptive media (AM), iron removal (IR), coagulation/filtration (C/F), ion exchange (IX), reverse osmosis, and point-of-use devices, which reduced the arsenic to less than the EPA maximum contaminant level of 10 mu g/L. This paper presents the capital and O&M cost of 48 treatment systems ranging in size from 10 to 770 gal/min (gpm) (382,915 L/min). The capital cost of the systems ranged from $477 to $6,171 per gpm ($126-$1,632 per L/min) of design flow and the O&M cost from $0.07 to $22.88 per 1,000 gal ($0.02-$6.05 per 1,000 L) of treated water. AM had a lower capital, but a higher O&M cost than IR, C/F, and IX. The media replacement cost for the AM systems averaged 80% of the O&M cost and was the main cause of the higher O&M cost of the AM systems.
C1 [Sorg, Thomas J.] US EPA, Cincinnati, OH 45268 USA.
[Wang, Lili] US EPA, Washington, DC 20460 USA.
[Chen, Abraham S. C.] ALSA Tech LLC, Powell, OH 43065 USA.
RP Sorg, TJ (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM sorg.thomas@epa.gov
FU US Environmental Protection Agency, through its Office of Research and
Development
FX The authors wish to thank the Battelle project team for coordinating the
performance evaluation studies, data handling, and analyses efforts. The
authors also acknowledge the system operators for their data collection
efforts. The US Environmental Protection Agency, through its Office of
Research and Development, funded, managed, and collaborated in the
research described herein. This paper has been subjected to the Agency's
administrative review and has been approved for external publication.
Any opinions expressed in this paper are those of the author(s) and do
not necessarily reflect the views of the Agency, therefore, no official
endorsement should be inferred. Any mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
NR 10
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Z9 2
U1 2
U2 12
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0003-7214
EI 1365-2087
J9 J WATER SUPPLY RES T
JI J. Water Supply Res Technol.-Aqua
PY 2015
VL 64
IS 3
BP 219
EP 234
DI 10.2166/aqua.2014.044
PG 16
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA CH8JD
UT WOS:000354281700001
ER
PT J
AU Das, KP
Grey, BE
Rosen, MB
Wood, CR
Tatum-Gibbs, KR
Zehr, RD
Strynar, MJ
Lindstrom, AB
Lau, C
AF Das, Kaberi P.
Grey, Brian E.
Rosen, Mitchell B.
Wood, Carmen R.
Tatum-Gibbs, Katoria R.
Zehr, R. Daniel
Strynar, Mark J.
Lindstrom, Andrew B.
Lau, Christopher
TI Developmental toxicity of perfluorononanoic acid in mice
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Perfluorononanoic acid; CD-1 mice; Developmental toxicity; Gene
expression
ID ACTIVATED RECEPTOR-ALPHA; PERFLUOROOCTANE SULFONATE PFOS; ATTENTION
DEFICIT/HYPERACTIVITY DISORDER; EXPOSED MOUSE FETUSES; HUMAN SEMEN
QUALITY; IN-UTERO EXPOSURE; PERFLUORINATED CHEMICALS; PERFLUOROALKYL
ACIDS; PPAR-ALPHA; POLYFLUOROALKYL CHEMICALS
AB Perfluorononanoic acid (PFNA) is a ubiquitous and persistent environmental contaminant. Although its levels in the environment and in humans are lower than those of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA), a steady trend of increases in the general population in recent years has drawn considerable interest and concern. Previous studies with PFOS and PFOA have indicated developmental toxicity in laboratory rodent models. The current study extends the evaluation of these adverse outcomes to PFNA in mice. PFNA was given to timed-pregnant CD-I mice by oral gavage daily on gestational day 1-17 at 1, 3, 5 or 10 mg/kg; controls received water vehicle. Dams given 10 mg/kg PFNA could not carry their pregnancy successfully and effects of this dose group were not followed. Similar to PFOS and PFOA, PFNA at 5 mg/kg or lower doses produced hepatomegaly in the pregnant dams, but did not affect the number of implantations, fetal viability, or fetal weight. Mouse pups were born alive and postnatal survival in the I and 3 mg/kg PFNA groups was not different from that in controls. In contrast, although most of the pups were also born alive in the 5 mg/kg PFNA group, 80% of these neonates died in the first 10 days of life. The pattern of PFNA-induced neonatal death differed somewhat from those elicited by PFOS or PFOA. A majority of the PFNA-exposed pups survived a few days longer after birth than those exposed to PFOS or PFOA, which typically died within the first 2 days of postnatal life. Surviving neonates exposed to PFNA exhibited dose-dependent delays in eye opening and onset of puberty. In addition, increased liver weight seen in PFNA-exposed offspring persisted into adulthood and was likely related to the persistence of the chemical in the tissue. Evaluation of gene expression in fetal and neonatal livers revealed robust activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) target genes by PFNA that resembled the responses of PFOA. Our results indicate that developmental toxicity of PFNA in mice is comparable to that of PFOS and PFOA, and that these adverse effects are likely common to perfluoroalkyl acids that persist in the body. Published by Elsevier Inc.
C1 [Das, Kaberi P.; Grey, Brian E.; Wood, Carmen R.; Tatum-Gibbs, Katoria R.; Lau, Christopher] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
[Rosen, Mitchell B.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Zehr, R. Daniel] US EPA, Res Core Unit, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Strynar, Mark J.; Lindstrom, Andrew B.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lau, C (reprint author), US EPA, Mail Drop 8105-04, Res Triangle Pk, NC 27711 USA.
EM lau.christopher@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 85
TC 6
Z9 6
U1 2
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JAN
PY 2015
VL 51
BP 133
EP 144
DI 10.1016/j.reprotox.2014.12.012
PG 12
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA CH6NH
UT WOS:000354152800016
PM 25543169
ER
PT J
AU Bouhifd, M
Andersen, ME
Baghdikian, C
Boekelheide, K
Crofton, KM
Fornace, AJ
Kleensang, A
Li, HH
Livi, C
Maertens, A
McMullen, PD
Rosenberg, M
Thomas, R
Vantangoli, M
Yager, JD
Zhao, L
Hartung, T
AF Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace, Albert J., Jr.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
McMullen, Patrick D.
Rosenberg, Michael
Thomas, Russell
Vantangoli, Marguerite
Yager, James D.
Zhao, Liang
Hartung, Thomas
TI The Human Toxome Project
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE regulatory toxicology; safety sciences; transcriptomics; metabolomics;
alternative methods
ID EVIDENCE-BASED TOXICOLOGY; GREEN FLUORESCENT PROTEIN;
ESTROGEN-RECEPTOR-ALPHA; CELL-CULTURE PRACTICE; BREAST-CANCER CELLS;
RISK-ASSESSMENT; BISPHENOL-A; 21(ST) CENTURY; REGULATORY USE; DNA-DAMAGE
AB The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.
C1 [Bouhifd, Mounir; Kleensang, Andre; Maertens, Alexandra; Zhao, Liang; Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA.
[Andersen, Melvin E.; McMullen, Patrick D.] Hamner Inst, Res Triangle Pk, NC USA.
[Baghdikian, Christina; Crofton, Kevin M.; Thomas, Russell] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Boekelheide, Kim; Vantangoli, Marguerite] Brown Univ, Pathol & Lab Med, Providence, RI 02912 USA.
[Fornace, Albert J., Jr.; Li, Henghong] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
[Livi, Carolina; Rosenberg, Michael] Agilent Inc, Santa Clara, CA USA.
[Yager, James D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Hartung, Thomas] Univ Konstanz, Ctr Alternat Anim Testing Europe, Constance, Germany.
RP Hartung, T (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, 615 N Wolfe St,W7032, Baltimore, MD 21205 USA.
EM thartung@jhsph.edu
RI Crofton, Kevin/J-4798-2015; Zhao, Liang/I-4777-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Zhao, Liang/0000-0002-2126-6778;
Fornace, Albert/0000-0001-9695-085X; Thomas,
Russell/0000-0002-2340-0301; Kleensang, Andre/0000-0002-4564-7399
FU NIH Transformation Research Grant, "Mapping the Human Toxome by Systems
Toxicsology" [RO1 ES 020750]; Food and Drug Administration Grant
"DNTox-21c Identification of Pathways of Developmental Neurotoxicity for
High Throughput Testing by Metabolomies" [U01 FD 004230]
FX The employment affiliations of the authors of this paper are as shown on
the cover page. Ten of the authors are affiliated with universities that
have traditional roles of teaching, research and service. Two of the
authors are associated with the U.S. Environmental Protection Agency.
Two of the authors are associated with a non-profit institution, The
Hamner Institute, which has an interest in advancing the science of
toxicology and risk assessment. And two of the authors are employees of
Agilent Technologies, Inc., a for-profit company that provides advanced
bio-analytical equipment and measurement services to a wide range of
clients. The individual authors were compensated by their respective
employers. In some cases, funding was provided by an NIH Transformation
Research Grant, "Mapping the Human Toxome by Systems Toxicsology" (RO1
ES 020750) to Johns Hopkins Bloomberg School of Public Health (PI Thomas
Hartung) and Food and Drug Administration Grant "DNTox-21c
Identification of Pathways of Developmental Neurotoxicity for High
Throughput Testing by Metabolomies" (U01 FD 004230) to Johns Hopkins
Bloomberg School of Public Health (PI Thomas Hartung). The analyses,
interpretations and conclusions presented in this paper are the
professional work product of the authors and may not necessarily
represent the views of their employers.
NR 102
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Z9 20
U1 3
U2 13
PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
PI HEILDEBERG
PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY
SN 1868-596X
EI 1868-8551
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2015
VL 32
IS 2
BP 112
EP 124
DI 10.14573/altex.1502091
PG 13
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CG9UZ
UT WOS:000353666900004
PM 25742299
ER
PT J
AU Sangani, RG
Ghio, AJ
Parker, JE
AF Sangani, Rahul G.
Ghio, Andrew J.
Parker, John E.
TI Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis
SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
LA English
DT Letter
C1 [Sangani, Rahul G.; Parker, John E.] W Virginia Univ, Dept Pulm & Crit Care Med, Morgantown, WV 26505 USA.
[Ghio, Andrew J.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Sangani, RG (reprint author), W Virginia Univ, Dept Pulm & Crit Care Med, Robert C Byrd Hlth Sci Ctr, 1 Med Ctr Dr, Morgantown, WV 26505 USA.
EM rgsangani@hsc.wvu.edu
NR 6
TC 0
Z9 1
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2005
J9 INT J CHRONIC OBSTR
JI Int. J. Chronic Obstr. Pulm. Dis.
PY 2015
VL 10
BP 869
EP 870
DI 10.2147/COPD.S83564
PG 2
WC Respiratory System
SC Respiratory System
GA CH2XD
UT WOS:000353887500001
PM 25999705
ER
PT J
AU Harper, M
Butler, C
Berry, D
Wroble, J
AF Harper, Martin
Butler, Corey
Berry, David
Wroble, Julie
TI Where Occupation and Environment Overlap: US Forest Service Worker
Exposure to Libby Amphibole Fibers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
ID MONTANA
AB The National Institute for Occupational Safety and Health (NIOSH) conducted an evaluation of exposures to asbestiform amphibole, known as Libby Amphibole (LA), to personnel from the US Department of Agriculture-Forest Service (USFS) working in the Kootenai National Forest near a former vermiculite mine close to Libby, Montana. LA is associated with vermiculite that was obtained from this mine; mining and processing over many years have resulted in the spread of LA into the surrounding Kootenai Forest where it has been found in tree bark, soil, and forest floor litter. As a result of this and other contamination, Libby and surrounding areas have been designated a "Superfund" site by the US Environmental Protection Agency (EPA). This article describes the application of EPA methods for assessing cancer risks to NIOSH sampling results. Phase-contrast microscopy for airborne asbestos fiber evaluation was found to be less useful than transmission electron microscopy in the presence of interfering organic (plant) fibers. NIOSH Method 7402 was extended by examination of larger areas of the filter, but fiber counts remained low. There are differences between counting rules in NIOSH 7402 and the ISO method used by EPA but these are minor in the context of the uncertainty in concentration estimates from the low counts. Estimates for cancer risk are generally compatible with those previously estimated by the EPA. However, there are limitations to extrapolating these findings of low risk throughout the entire area and to tasks that were not evaluated.
C1 [Harper, Martin] NIOSH, Hlth Effects Lab Div, Exposure Assessment Branch, Morgantown, WV 26505 USA.
[Butler, Corey] NIOSH, Western States Off, Denver, CO USA.
[Berry, David] US EPA, Denver, CO USA.
[Wroble, Julie] US EPA, Seattle, WA USA.
RP Harper, M (reprint author), NIOSH, Hlth Effects Lab Div, Exposure Assessment Branch, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM zzg7@cdc.gov
FU Intramural CDC HHS [CC999999]
NR 14
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U1 1
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1545-9624
EI 1545-9632
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PY 2015
VL 12
IS 5
BP D47
EP D53
DI 10.1080/15459624.2014.989362
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA CG8UP
UT WOS:000353590000001
PM 25715191
ER
PT J
AU Lewandowski, M
Jaoui, M
Offenberg, JH
Krug, JD
Kleindienst, TE
AF Lewandowski, M.
Jaoui, M.
Offenberg, J. H.
Krug, J. D.
Kleindienst, T. E.
TI Atmospheric oxidation of isoprene and 1,3-butadiene: influence of
aerosol acidity and relative humidity on secondary organic aerosol
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID ENVIRONMENTAL TOBACCO-SMOKE; HIGH-NOX CONDITIONS; OCCUPATIONAL
EXPOSURES; BUTADIENE; PHOTOOXIDATION; MODEL; EMISSIONS; EPOXIDE; CARBON;
ORGANOSULFATES
AB The effects of acidic seed aerosols on the formation of secondary organic aerosol (SOA) have been examined in a number of previous studies, several of which have observed strong linear correlations between the aerosol acidity (measured as nmol H+ m(-3) air sample volume) and the percent change in secondary organic carbon (SOC). The measurements have used several precursor compounds representative of different classes of biogenic hydrocarbons including isoprene, monoterpenes, and sesquiterpenes. To date, isoprene has displayed the most pronounced increase in SOC, although few measurements have been conducted with anthropogenic hydrocarbons. In the present study, we examine several aspects of the effect of aerosol acidity on the secondary organic carbon formation from the photooxidation of 1,3-butadiene, and extend the previous analysis of isoprene. The photooxidation products measured in the absence and presence of acidic sulfate aerosols were generated either through photochemical oxidation of SO2 or by nebulizing mixtures of ammonium sulfate and sulfuric acid into a 14.5 m(3) smog chamber system. The results showed that, like isoprene and beta-caryophyllene, 1,3-butadiene SOC yields linearly correlate with increasing acidic sulfate aerosol. The observed acid sensitivity of 0.11% SOC increase per nmol m(-3) increase in H+ was approximately a factor of 3 less than that measured for isoprene. The results also showed that the aerosol yield decreased with increasing humidity for both isoprene and 1,3-butadiene, although to different degrees. Increasing the absolute humidity from 2 to 12 gm(-3) reduced the 1,3-butadiene yield by 45% and the isoprene yield by 85 %.
C1 [Lewandowski, M.; Offenberg, J. H.; Krug, J. D.; Kleindienst, T. E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Jaoui, M.] Alion Sci & Technol Inc, Res Triangle Pk, NC 27709 USA.
RP Lewandowski, M (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM lewandowski.michael@epa.gov
RI Offenberg, John/C-3787-2009
OI Offenberg, John/0000-0002-0213-4024
FU US Environmental Protection Agency through Office of Research and
Development [EP-D-10-070]
FX The US Environmental Protection Agency through its Office of Research
and Development funded and collaborated in the research described here
under contract EP-D-10-070 to Alion Science and Technology. It has been
subject to agency review and approved for publication. Mention of trade
names or commercial products does not constitute an endorsement or
recommendation for use.
NR 39
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U1 8
U2 51
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 7
BP 3773
EP 3783
DI 10.5194/acp-15-3773-2015
PG 11
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CG0LF
UT WOS:000352957400009
ER
PT J
AU Yu, L
Fennel, K
Laurent, A
Murrell, MC
Lehrter, JC
AF Yu, L.
Fennel, K.
Laurent, A.
Murrell, M. C.
Lehrter, J. C.
TI Numerical analysis of the primary processes controlling oxygen dynamics
on the Louisiana shelf
SO BIOGEOSCIENCES
LA English
DT Article
ID GULF-OF-MEXICO; MISSISSIPPI RIVER PLUME; EUTROPHIC COASTAL ECOSYSTEM;
CONTINENTAL-SHELF; CHESAPEAKE BAY; SKILL ASSESSMENT; SUMMER HYPOXIA;
WATER COLUMN; MODEL; VARIABILITY
AB The Louisiana shelf, in the northern Gulf of Mexico, receives large amounts of freshwater and nutrients from the Mississippi-Atchafalaya river system. These river inputs contribute to widespread bottom-water hypoxia every summer. In this study, we use a physical-biogeochemical model that explicitly simulates oxygen sources and sinks on the Louisiana shelf to identify the key mechanisms controlling hypoxia development. First, we validate the model simulation against observed dissolved oxygen concentrations, primary production, water column respiration, and sediment oxygen consumption. In the model simulation, heterotrophy is prevalent in shelf waters throughout the year, except near the mouths of the Mississippi and Atchafalaya rivers, where primary production exceeds respiratory oxygen consumption during June and July. During this time, efflux of oxygen to the atmosphere, driven by photosynthesis and surface warming, becomes a significant oxygen sink. A substantial fraction of primary production occurs below the pycnocline in summer. We investigate whether this primary production below the pycnocline is mitigating the development of hypoxic conditions with the help of a sensitivity experiment where we disable biological processes in the water column (i.e., primary production and water column respiration). With this experiment we show that below-pycnocline primary production reduces the spatial extent of hypoxic bottom waters only slightly. Our results suggest that the combination of physical processes (advection and vertical diffusion) and sediment oxygen consumption largely determine the spatial extent and dynamics of hypoxia on the Louisiana shelf.
C1 [Yu, L.; Fennel, K.; Laurent, A.] Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada.
[Murrell, M. C.; Lehrter, J. C.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Yu, L (reprint author), Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada.
EM liuqian.yu@dal.ca
RI Fennel, Katja/A-7470-2009;
OI Fennel, Katja/0000-0003-3170-2331; Laurent, Arnaud/0000-0002-8545-9309
FU NOAA CSCOR grants [NA06N0S4780198]; US IOOS Coastal Ocean Modeling
Testbed
FX This work was supported through NOAA CSCOR grants NA06N0S4780198 and the
US IOOS Coastal Ocean Modeling Testbed. NOAA NGOMEX publication no. 202.
NR 58
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U1 1
U2 13
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1726-4170
EI 1726-4189
J9 BIOGEOSCIENCES
JI Biogeosciences
PY 2015
VL 12
IS 7
BP 2063
EP 2076
DI 10.5194/bg-12-2063-2015
PG 14
WC Ecology; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA CG0LP
UT WOS:000352958400001
ER
PT J
AU Druschke, CG
Hychka, KC
AF Druschke, Caroline Gottschalk
Hychka, Kristen C.
TI Manager perspectives on communication and public engagement in
ecological restoration project success
SO ECOLOGY AND SOCIETY
LA English
DT Article
DE adaptive comanagement; adaptive management; communication; discourse
analysis; natural resource management; public engagement; public
participation; restoration; river; stakeholder engagement; water
ID RIVER RESTORATION; PARTICIPATION; SCIENTISTS; SYSTEMS; TIME
AB We look to a particular social-ecological system, the restoration community in Rhode Island, USA and the rivers, wetlands, marshes, and estuaries they work to protect, to draw connections between communication, community involvement, and ecological restoration project success. Offering real-world examples drawn from interviews with 27 local, state, federal, and nonprofit restoration managers, we synthesize the mechanisms that managers found effective to argue that the communication employed by resource managers in each phase of the restoration process, in prioritization, implementation, and monitoring, and for garnering broad-based support, shapes the quality of public engagement in natural resources management, which, in turn, can impact the stakeholder, learning, and ecological success of restoration projects. Despite the possible trade-offs and conflicts between social and ecological outcomes, we suggest that managers need to consider their desired social-ecological outcomes and work from the outset to deliberately design mechanisms for communication and public engagement that weave community stakeholders into all phases of restoration projects in sustained and consequential ways.
C1 [Druschke, Caroline Gottschalk] Univ Rhode Isl, Kingston, RI 02881 USA.
[Hychka, Kristen C.] US EPA, Atlantic Ecol Div, Washington, DC USA.
RP Druschke, CG (reprint author), Univ Rhode Isl, Kingston, RI 02881 USA.
NR 36
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U1 11
U2 36
PU RESILIENCE ALLIANCE
PI WOLFVILLE
PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA
SN 1708-3087
J9 ECOL SOC
JI Ecol. Soc.
PY 2015
VL 20
IS 1
AR 58
DI 10.5751/ES-07451-200158
PG 9
WC Ecology; Environmental Studies
SC Environmental Sciences & Ecology
GA CG4XW
UT WOS:000353293900067
ER
PT J
AU Schaeffer, BA
Conmy, RN
Duffy, AE
Aukamp, J
Yates, DF
Craven, G
AF Schaeffer, Blake A.
Conmy, Robyn N.
Duffy, Allyn E.
Aukamp, Jessica
Yates, Diane F.
Craven, George
TI Northern Gulf of Mexico estuarine coloured dissolved organic matter
derived from MODIS data
SO INTERNATIONAL JOURNAL OF REMOTE SENSING
LA English
DT Article
ID WATER-QUALITY INDICATORS; OCEAN COLOR; COASTAL WATERS;
OPTICAL-PROPERTIES; CLYDE SEA; TAMPA-BAY; VARIABILITY; SEAWIFS; FLORIDA;
CARBON
AB Coloured dissolved organic matter (CDOM) is relevant for water quality management and may become an important measure to complement future water quality assessment programmes. An approach to derive CDOM using the Moderate Resolution Imaging Spectroradiometer (MODIS) was developed that may be more accessible to water quality managers by selecting an off-the-shelf software and algorithm with standard atmospheric correction. This study focused on demonstrating the transferability of a remote-sensing reflectance (R-rs) band ratio algorithm, R-rs(667)/R-rs(488), previously developed to derive CDOM absorption (a(g(lambda))) at multiple MODIS wavebands in open ocean and coastal waters to the United States northern Gulf of Mexico estuaries. In situ calibration regressions at 412, 443, 469, and 488 nm had coefficients of determination (R-2) of 0.76, 0.71, 0.69, and 0.57, respectively. Waveband calibrations at 531, 547, and 555 nm were below R-2 = 0.50, and therefore were not considered further. MODIS R-rs, from the standard atmospheric correction, followed nearly identical spectral shapes to the in situ HyperSAS R-rs, but were on average 0.002 + 0.0004 sr(-1) less. A satellite to in situ validation match-up window of <= 1 hour was selected with an R-2 = 0.82 and root mean square error (RMSE = 1.79) at 412 nm. An in situ water quality mooring demonstrated that the overall response and range of MODIS a(g(412)) were similar, with relative mean error from -32% to 42%. The advantage to managers was synoptic coverage across multiple estuaries and the ability to provide estimates of derived water quality parameters between the water quality assessment programme sample collection periods, which could offer more holistic assessment.
C1 [Schaeffer, Blake A.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Conmy, Robyn N.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Duffy, Allyn E.; Aukamp, Jessica; Yates, Diane F.; Craven, George] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Breeze, FL USA.
RP Schaeffer, BA (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM schaeffer.blake@epa.gov
FU US Environmental Protection Agency; NASA [NNH08ZDA001N-DECISIONS]
FX The information in this document has been funded in part by the US
Environmental Protection Agency and NASA Grant # NNH08ZDA001N-DECISIONS.
NR 53
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U1 2
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0143-1161
EI 1366-5901
J9 INT J REMOTE SENS
JI Int. J. Remote Sens.
PY 2015
VL 36
IS 8
BP 2219
EP 2237
DI 10.1080/01431161.2015.1035408
PG 19
WC Remote Sensing; Imaging Science & Photographic Technology
SC Remote Sensing; Imaging Science & Photographic Technology
GA CG8RG
UT WOS:000353577600013
ER
PT J
AU Oczkowski, A
Thornber, CS
Markham, EE
Rossi, R
Ziegler, A
Rinehart, S
AF Oczkowski, Autumn
Thornber, Carol S.
Markham, Erin E.
Rossi, Ryann
Ziegler, Amanda
Rinehart, Shelby
TI Testing sample stability using four storage methods and the macroalgae
Ulva and Gracilaria
SO LIMNOLOGY AND OCEANOGRAPHY-METHODS
LA English
DT Article
ID ANTHROPOGENIC NITROGEN
AB Concern over the relative importance of different sample preparation and storage techniques frequently used in stable isotope analysis of particulate nitrogen (delta N-15) and carbon (delta C-13) prompted an experiment to determine how important such factors were to measured values in marine organisms. We stored the marine macroalgae Ulva and Gracilaria in four different ways and analyzed replicates every three months over the course of a year to assess treatment effects on stability. Treatments consisted of algae dried at 65 degrees C, ground to a powder, and stored in a desiccator until analysis; algae left in a drying oven or in a freezer and processed (dried and ground) just prior to analysis, as well as some dried, ground samples kept out in the lab and reanalyzed quarterly for 12 months. Concurrently, to assess the ecological range in isotope values over the course of a year, samples were freshly collected from the same location and analyzed along with the other treatments at each time step. Neither storage technique nor time had an impact on either delta N-15 or delta C-13 values or the %N and %C of the algae tissues. There were clear and consistent differences between species and some large seasonal differences in the freshly collected samples. The interspecies differences and seasonal ranges of values underscore the stability associated with method and duration of sample storage.
C1 [Oczkowski, Autumn; Markham, Erin E.; Rossi, Ryann] US EPA, Grad Sch Oceanog, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Thornber, Carol S.; Ziegler, Amanda; Rinehart, Shelby] Univ Rhode Isl, Dept Biol Sci, Kingston, RI 02881 USA.
RP Oczkowski, A (reprint author), US EPA, Grad Sch Oceanog, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM Oczkowski.Autumn@epa.gov
FU University of Rhode Island; National Science Foundation EPSCoR
Cooperative Agreement [EPS-1004057]; State of Rhode Island; U.S.
Environmental Protection Agency
FX Thank you to R. McKinney for assistance with sample analysis, and to J.
Carey, R. Johnson, and M. Pelletier for providing useful edits of this
manuscript. Partial funding was provided by the University of Rhode
Island through an undergraduate research grant to A. Ziegler. This
material is based, in part, upon work supported in part by the National
Science Foundation EPSCoR Cooperative Agreement #EPS-1004057 and the
State of Rhode Island. This is ORD Tracking Number ORD-008193 of the
Atlantic Ecology Division, National Health and Environmental Effects
Research Laboratory, Office of Research and Development, U.S.
Environmental Protection Agency. Although the research described in this
article has been funded in part by the U.S. Environmental Protection
Agency, it has not been subjected to Agency review. Therefore, it does
not necessarily reflect the views of the Agency.
NR 10
TC 0
Z9 0
U1 3
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1541-5856
J9 LIMNOL OCEANOGR-METH
JI Limnol. Oceanogr. Meth.
PD JAN
PY 2015
VL 13
IS 1
BP 9
EP 14
DI 10.1002/lom3.10002
PG 6
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA CG8KH
UT WOS:000353555800002
ER
PT J
AU Trebitz, AS
Hoffman, JC
AF Trebitz, Anett S.
Hoffman, Joel C.
TI Coastal Wetland Support of Great Lakes Fisheries: Progress from Concept
to Quantification
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID FRESH-WATER ECOSYSTEMS; ESSENTIAL FISH HABITAT; YELLOW PERCH; LARVAL
FISHES; ENVIRONMENTAL INDICATORS; SAMPLING DESIGN; LARGEMOUTH BASS;
FORAGE FISH; LAND-USE; MICHIGAN
AB Fishery support is recognized as a valuable ecosystem service provided by aquatic systems, but it is harder to quantify than to describe conceptually. In this paper, we combine data on fish inhabiting Great Lakes coastal wetlands (GLCWs) with information on commercial and recreational harvest and the piscivore forage base to develop quantitative understanding of the multiple species involved in direct and indirect fishery support of this complex fishery. We then examine patterns of species co-occurrence and life history and relationships to GLCW conditions in order to identify fishery support metrics useful in aggregating species patterns and evaluating management outcomes. Our criteria for wetland prevalence (>= 10% occurrence) and fishery importance (>= 1% of recreational or commercial harvest in one or more of the Great Lakes or having a major forage fish role) yielded 21 wetland-using, fishery-relevant species representing multiple taxonomic groups and life history attributes. Wetland-using species are estimated to make up half the biomass and 60% of the dollar value of the fish landed commercially and similar to 80% of the fish numbers harvested recreationally. All of the GLCWs studied supported species of interest to recreational and commercial fishers but with widely varying composition. A few key habitat characteristics (e.g., vegetation structure) are broadly predictive of the types of sport and panfish present, with more degraded GLCWs generally supporting abundant but lower-value taxa (rough-fish species) and less degraded GLCWs supporting fewer but higher-value taxa (sport and panfish species). No single taxonomic or functional metric seems adequate to capture the diversity of fishery-relevant species supported by GLCWs; fishery support needs to be understood and managed in a multimetric context.
C1 [Trebitz, Anett S.; Hoffman, Joel C.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Trebitz, AS (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM trebitz.anett@epa.gov
NR 123
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U1 5
U2 29
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0002-8487
EI 1548-8659
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PY 2015
VL 144
IS 2
BP 352
EP 372
DI 10.1080/00028487.2014.982257
PG 21
WC Fisheries
SC Fisheries
GA CF7HE
UT WOS:000352726200013
ER
PT J
AU Heenan, J
Slater, LD
Ntarlagiannis, D
Atekwana, EA
Fathepure, BZ
Dalvi, S
Ross, C
Werkema, DD
Atekwana, EA
AF Heenan, Jeffrey
Slater, Lee D.
Ntarlagiannis, Dimitrios
Atekwana, Estella A.
Fathepure, Babu Z.
Dalvi, Sonal
Ross, Cameron
Werkema, Dale D.
Atekwana, Eliot A.
TI Electrical resistivity imaging for long-term autonomous monitoring of
hydrocarbon degradation: Lessons from the Deepwater Horizon oil spill
SO GEOPHYSICS
LA English
DT Article
ID ATTENUATION ANALYSIS; PHENOL HYDROXYLASE; DC RESISTIVITY; TOMOGRAPHY;
SEDIMENTS; BACTERIA; BIODEGRADATION; SIGNATURES; INVERSION; TRANSPORT
AB Conceptual models for the geophysical responses associated with hydrocarbon degradation suggest that the long-term evolution of an oil plume will result in a more conductive anomaly than the initial contamination. In response to the Deepwater Horizon (DH) oil spill into the Gulf of Mexico in 2010, an autonomous resistivity monitoring system was deployed on Grand Terre, Louisiana, in an attempt to monitor natural degradation processes in hydrocarbon-impacted beach sediments of this island. A 48-electrode surface array with a 0.5-m spacing was installed to obtain twice-daily images of the resistivity structure of the shallow subsurface impacted by oil. Over the course of approximately 18 months, we observed a progressive decrease in the resistivity of the DH spill-impacted region. Detailed analysis of pixel/point resistivity variation within the imaged area showed that long-term decreases in resistivity were largely associated with the DH-impacted sediments. A microbial diversity survey revealed the presence of hydrocarbon-degrading organisms throughout the test site. However, hydrocarbon degradation activity was much higher in the DH-impacted locations compared to nonimpacted locations, suggesting the presence of active hydrocarbon degraders, supporting biodegradation processes. The results of this long-term monitoring experiment suggested that resistivity might be used to noninvasively monitor the long-term degradation of crude oil spills.
C1 [Heenan, Jeffrey; Slater, Lee D.; Ntarlagiannis, Dimitrios] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA.
[Atekwana, Estella A.; Ross, Cameron; Atekwana, Eliot A.] Oklahoma State Univ, Boone Pickens Sch Geol, Stillwater, OK 74078 USA.
[Fathepure, Babu Z.; Dalvi, Sonal] Oklahoma State Univ, Microbiol & Mol Genet, Stillwater, OK 74078 USA.
[Werkema, Dale D.] US EPA, Las Vegas, NV 89193 USA.
RP Heenan, J (reprint author), Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA.
EM jheenan@pegasus.rutgers.edu; lslater@rutgers.edu; dimntar@rutgers.edu;
estella.atekwana@okstate.edu; babu.fathepure@okstate.edu;
sonal.dalvi@okstate.edu; camersr@ostatemail.okstate.edu;
werkema.d@epamail.epa.gov; eliot.atekwana@okstate.edu
OI atekwana, eliot/0000-0002-4934-650X
FU United States Environmental Protection Agency National Exposure Research
Laboratory, Office of Research and Development Student Services
[RFQ-RT-11-00103]; National Science Foundation [OCE-1049301]; American
Chemical Society, Petroleum Research Fund [49823-ND8]; Chevron Energy
Corporation
FX This work was supported by the United States Environmental Protection
Agency National Exposure Research Laboratory, Office of Research and
Development Student Services Contract RFQ-RT-11-00103 to J. Heenan,
National Science Foundation RAPID Award, OCE-1049301, American Chemical
Society, Petroleum Research Fund, grant no. 49823-ND8, and the Chevron
Energy Corporation.
NR 43
TC 3
Z9 3
U1 2
U2 7
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
EI 1942-2156
J9 GEOPHYSICS
JI Geophysics
PD JAN-FEB
PY 2015
VL 80
IS 1
BP B1
EP B11
DI 10.1190/GEO2013-0468.1
PG 11
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CE8PN
UT WOS:000352105900005
ER
PT J
AU Gantt, B
Johnson, MS
Crippa, M
Prevot, ASH
Meskhidze, N
AF Gantt, B.
Johnson, M. S.
Crippa, M.
Prevot, A. S. H.
Meskhidze, N.
TI Implementing marine organic aerosols into the GEOS-Chem model
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SEA-SPRAY AEROSOL; SOURCE APPORTIONMENT; GLOBAL DISTRIBUTION; MATTER
ENRICHMENT; DRY DEPOSITION; ARCTIC-OCEAN; EMISSIONS; ISOPRENE;
PARAMETERIZATION; PARTICLES
AB Marine-sourced organic aerosols (MOAs) have been shown to play an important role in tropospheric chemistry by impacting surface mass, cloud condensation nuclei, and ice nuclei concentrations over remote marine and coastal regions. In this work, an online marine primary organic aerosol emission parameterization, designed to be used for both global and regional models, was implemented into the GEOS-Chem (Global Earth Observing System Chemistry) model. The implemented emission scheme improved the large underprediction of organic aerosol concentrations in clean marine regions (normalized mean bias decreases from -79% when using the default settings to -12% when marine organic aerosols are added). Model predictions were also in good agreement (correlation coefficient of 0.62 and normalized mean bias of -36%) with hourly surface concentrations of MOAs observed during the summertime at an inland site near Paris, France. Our study shows that MOAs have weaker coastal-to-inland concentration gradients than sea-salt aerosols, leading to several inland European cities having > 10% of their surface submicron organic aerosol mass concentration with a marine source. The addition of MOA tracers to GEOS-Chem enabled us to identify the regions with large contributions of freshly emitted or aged aerosol having distinct physicochemical properties, potentially indicating optimal locations for future field studies.
C1 [Gantt, B.; Meskhidze, N.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Johnson, M. S.] NASA, Ames Res Ctr, Div Earth Sci, Moffett Field, CA 94035 USA.
[Crippa, M.; Prevot, A. S. H.] Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
RP Gantt, B (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM bdgantt@gmail.com
RI Prevot, Andre/C-6677-2008; Chem, GEOS/C-5595-2014
OI Prevot, Andre/0000-0002-9243-8194;
FU Office of Science (BER), US Department of Energy [DEFG02-08ER64508];
National Science Foundation [ATM-0826117]; National Aeronautics & Space
Administration (NASA) [NNX11AG72G]; European Community [212520]; Office
of Research and Development, US EPA
FX This research was supported by the Office of Science (BER), US
Department of Energy grant no. DEFG02-08ER64508, National Science
Foundation grant no. ATM-0826117, and National Aeronautics & Space
Administration (NASA) through grant no. NNX11AG72G. The measurements in
Paris were conducted in the MEGAPOLI project, mainly financially
supported by the European Community's Framework Program FP/2007-2011
under grant agreement no. 212520. The authors would like to thank Daniel
Jacob and the Harvard University Atmospheric Chemistry Modeling Group
for providing the base GEOS-Chem model used during our research.
Resources supporting this work were provided by the NASA High-End
Computing (HEC) Program through the NASA Advanced Supercomputing (NAS)
Division at NASA Ames Research Center. B. Gantt is supported by an
appointment to the Research Participation Program at the Office of
Research and Development, US EPA, administered by ORISE.
NR 62
TC 0
Z9 0
U1 6
U2 26
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 3
BP 619
EP 629
DI 10.5194/gmd-8-619-2015
PG 11
WC Geosciences, Multidisciplinary
SC Geology
GA CE9JM
UT WOS:000352160200010
ER
PT J
AU Duan, WL
He, B
Takara, K
Luo, PP
Nover, D
Hu, MC
AF Duan, W. L.
He, B.
Takara, K.
Luo, P. P.
Nover, D.
Hu, M. C.
TI Modeling suspended sediment sources and transport in the Ishikari River
basin, Japan, using SPARROW
SO HYDROLOGY AND EARTH SYSTEM SCIENCES
LA English
DT Article
ID SPATIALLY REFERENCED REGRESSION; GULF-OF-MEXICO; LAND-USE;
WATER-QUALITY; SOIL-EROSION; NITROGEN DELIVERY; PHOSPHORUS; IMPACT;
CHANNEL; RUNOFF
AB It is important to understand the mechanisms that control the fate and transport of suspended sediment (SS) in rivers, because high suspended sediment loads have significant impacts on riverine hydroecology. In this study, the SPARROW (SPAtially Referenced Regression on Watershed Attributes) watershed model was applied to estimate the sources and transport of SS in surface waters of the Ishikari River basin (14 330 km(2)), the largest watershed in Hokkaido, Japan. The final developed SPARROW model has four source variables (developing lands, forest lands, agricultural lands, and stream channels), three landscape delivery variables (slope, soil permeability, and precipitation), two in-stream loss coefficients, including small streams (streams with drainage area < 200 km(2)) and large streams, and reservoir attenuation. The model was calibrated using measurements of SS from 31 monitoring sites of mixed spatial data on topography, soils and stream hydrography. Calibration results explain approximately 96% (R-2) of the spatial variability in the natural logarithm mean annual SS flux (kg yr(-1)) and display relatively small prediction errors at the 31 monitoring stations. Results show that developing land is associated with the largest sediment yield at around 1006 kg km(-2) yr(-1), followed by agricultural land (234 kg km(-2) yr(-1)). Estimation of incremental yields shows that 35% comes from agricultural lands, 23% from forested lands, 23% from developing lands, and 19% from stream channels. The results of this study improve our understanding of sediment production and transportation in the Ishikari River basin in general, which will benefit both the scientific and management communities in safeguarding water resources.
C1 [Duan, W. L.; He, B.] Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing 210008, Jiangsu, Peoples R China.
[Duan, W. L.; Takara, K.; Hu, M. C.] Kyoto Univ, Disaster Prevent Res Inst, Kyoto, Japan.
[Luo, P. P.] Zhejiang Univ, Coll Civil Engn & Architecture, Inst Hydraul Struct Engn & Water Environm, Hangzhou 310003, Zhejiang, Peoples R China.
[Luo, P. P.] United Nations Univ, Inst Adv Study Sustainabil, Shibuya Ku, Tokyo, Japan.
[Nover, D.] US EPA, Global Change Res Grp, Washington, DC 20010 USA.
RP Duan, WL (reprint author), Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing 210008, Jiangsu, Peoples R China.
EM duan.scut.cn@gmail.com; hebin@niglas.ac.cn; luoping198121@gmail.com
FU National Natural Science Foundation of China [41471460]; "One Hundred
Talents Program" of Chinese Academy of Sciences; Kyoto University
Sustainability/Survivability Science for a Resilient Society Adaptable
to Extreme Weather Conditions Global COE program; Global Center for
Education and Research on Human Security Engineering for Asian
Megacities; Postdoctoral fellowship of Japan Society for the Promotion
of Science [P12055]; JSPS KAKENHI [24.02055]; JSPS (KAKENHI Wakate B)
[90569724]; China Scholarship Council (CSC)
FX This study is sponsored by National Natural Science Foundation of China
(No. 41471460) and "One Hundred Talents Program" of Chinese Academy of
Sciences, the Kyoto University Sustainability/Survivability Science for
a Resilient Society Adaptable to Extreme Weather Conditions Global COE
program and the Global Center for Education and Research on Human
Security Engineering for Asian Megacities, the Postdoctoral fellowship
of Japan Society for the Promotion of Science (P12055), JSPS KAKENHI
grant number 24.02055 and the JSPS Grant-in-Aid for Young Scientists (B)
(KAKENHI Wakate B, 90569724). We also wish to acknowledge Anne B. Hoos
and John W. Brakebill of the US Geological Survey for their help with
the use of the SPARROW model. The first author would like to thank the
China Scholarship Council (CSC) for his PhD scholarships.
NR 45
TC 4
Z9 4
U1 4
U2 19
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1027-5606
EI 1607-7938
J9 HYDROL EARTH SYST SC
JI Hydrol. Earth Syst. Sci.
PY 2015
VL 19
IS 3
BP 1293
EP 1306
DI 10.5194/hess-19-1293-2015
PG 14
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA CE9JQ
UT WOS:000352160600012
ER
PT J
AU Holeck, KT
Rudstam, LG
Watkins, JM
Luckey, FJ
Lantry, JR
Lantry, BF
Trometer, ES
Koops, MA
Johnson, TB
AF Holeck, K. T.
Rudstam, L. G.
Watkins, J. M.
Luckey, F. J.
Lantry, J. R.
Lantry, B. F.
Trometer, E. S.
Koops, M. A.
Johnson, T. B.
TI Lake Ontario water quality during the 2003 and 2008 intensive field
years and comparison with long-term trends
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE oligotrophication; phosphorus; silica; chlorophyll a; Secchi disc
transparency; trophic state
ID LAURENTIAN GREAT-LAKES; TOTAL PHOSPHORUS; CHLOROPHYLL-A; TROPHIC STATE;
FOOD-WEB; PHYTOPLANKTON; ZOOPLANKTON; NEARSHORE; EUTROPHICATION;
ENRICHMENT
AB Phosphorus loading declined between the 1970s and the 1990s, leading to oligotrophication of the offshore waters of Lake Ontario during that time period. Using lake-wide data from the intensive field years of 2003 and 2008 and from available long-term data sets on several trophic state indicators (total phosphorus [TP], soluble reactive silica [SRSi], chlorophyll a and Secchi disc transparency [SDT]), we tested the hypothesis that oligotrophication of the offshore waters of Lake Ontario has continued in the 2000s. Significant differences between 2003 and 2008 include higher spring (April) TP, SRSi, and SDT in 2008, lower summer (July-August) SDT in 2008, higher summer chlorophyll a in 2008, and lower fall (September) TP, SRSi, and chlorophyll a in 2008. The decline in SRSi from spring to summer was greater in 2008 than in 2003. Change point and regression analyses on the long-term data revealed no trend in spring TP since 1996, in summer chlorophyll a since 1994, in spring SDT since 1998, in spring SRSi or SRSi decline from spring to summer since 1999, or in summer SDT since 2001. Neither the comparison of the 2003 and 2008 surveys nor the analysis of the long-term data supported our hypothesis of continued oligotrophication of the offshore of Lake Ontario in the 2000s.
C1 [Holeck, K. T.; Rudstam, L. G.; Watkins, J. M.] Cornell Univ, Dept Nat Resources, Cornell Biol Field Stn, Bridgeport, NY 13030 USA.
[Luckey, F. J.] US EPA, New York, NY 10007 USA.
[Lantry, J. R.] New York State Dept Environm Conservat, Lake Ontario Fisheries Res Unit, Cape Vincent Fisheries Res Stn, Cape Vincent, NY 13618 USA.
[Lantry, B. F.] US Geol Survey, Great Lakes Sci Ctr, Lake Ontario Biol Stn, Oswego, NY 13126 USA.
[Trometer, E. S.] US Fish & Wildlife Serv, Lower Great Lakes Off, Basom, NY 14013 USA.
[Koops, M. A.] Fisheries & Oceans Canada, Great Lakes Lab Fisheries & Aquat Sci, Burlington, ON L7R 4A6, Canada.
[Johnson, T. B.] Ontario Minist Nat Resources, Glenora Fisheries Stn, Picton, ON K0K 2T0, Canada.
RP Holeck, KT (reprint author), Cornell Univ, Dept Nat Resources, Cornell Biol Field Stn, 900 Shackelton Pt Rd, Bridgeport, NY 13030 USA.
EM kth1@cornell.edu
RI Koops, Marten/A-4534-2010
OI Koops, Marten/0000-0002-3676-7946
FU EPA [97220700-0]; International Joint Commission
FX This work was funded by EPA Grant 97220700-0 to Cornell University as
part of the Great Lakes Restoration Initiative and a grant from the
International Joint Commission. Further support is provided by the
agencies collaborating in the lower trophic level assessments of Lake
Ontario (EPA GNLPO and Region 2, NYSDEC, USGS, USFWS, DFO, EC, OMNR).
NR 44
TC 7
Z9 7
U1 7
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1463-4988
EI 1539-4077
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2015
VL 18
IS 1
BP 7
EP 17
DI 10.1080/14634988.2015.1000787
PG 11
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CE3AI
UT WOS:000351695400003
ER
PT J
AU Rudstam, LG
Holeck, KT
Bowen, KL
Watkins, JM
Weidel, BC
Luckey, FJ
AF Rudstam, L. G.
Holeck, K. T.
Bowen, K. L.
Watkins, J. M.
Weidel, B. C.
Luckey, F. J.
TI Lake Ontario zooplankton in 2003 and 2008: Community changes and
vertical redistribution
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE calanoids; cyclopoids; bosminids; daphniids; Bythotrephes
ID LAURENTIAN GREAT-LAKES; LOWER FOOD-WEB; CLADOCERAN
BYTHOTREPHES-LONGIMANUS; ALEWIFE ALOSA-PSEUDOHARENGUS; WATER
SURVEILLANCE PROGRAM; SMELT OSMERUS-MORDAX; CERCOPAGIS-PENGOI; RAINBOW
SMELT; PREDATORY CLADOCERAN; CRUSTACEAN ZOOPLANKTON
AB Lake-wide zooplankton surveys are critical for documenting and understanding food web responses to ecosystem change. Surveys in 2003 and 2008 during the binational intensive field year in Lake Ontario found that offshore epilimnetic crustacean zooplankton declined by a factor of 12 (density) and factor of 5 (biomass) in the summer with smaller declines in the fall. These declines coincided with an increase in abundance of Bythotrephes and are likely the result of direct predation by, or behavioral responses to this invasive invertebrate predator. Whole water column zooplankton density also declined from 2003 to 2008 in the summer and fall (factor of 4), but biomass only declined in the fall (factor of 2). The decline in biomass was less than the decline in density because the average size of individual zooplankton increased. This was due to changes in the zooplankton community composition from a cyclopoid/bosminid dominated community in 2003 to a calanoid dominated community in 2008. The increase in calanoid copepods was primarily due to the larger species Limnocalanus macrurus and Leptodiaptomus sicilis. These cold water species were found in and below the thermocline associated with a deep chlorophyll layer. In 2008, most of the zooplankton biomass resided in or below the thermocline during the day. Increased importance of copepods in deeper, colder water may favor Cisco and Rainbow Smelt over Alewife because these species are better adapted to cold temperatures than Alewife.
C1 [Rudstam, L. G.; Holeck, K. T.; Watkins, J. M.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA.
[Rudstam, L. G.; Holeck, K. T.; Watkins, J. M.] Cornell Univ, Cornell Biol Field Stn, Ithaca, NY USA.
[Bowen, K. L.] Dept Fisheries & Oceans Canada, Burlington, ON, Canada.
[Weidel, B. C.] USGS Great Lakes Lab, Lake Ontario Biol Stn, Oswego, NY USA.
[Luckey, F. J.] US EPA, New York, NY USA.
RP Rudstam, LG (reprint author), Cornell Univ, Dept Nat Resources, Fernow Hall, Ithaca, NY 14853 USA.
EM lgr1@cornell.edu
FU EPA [97220700-0]; International Joint Commission
FX This work was funded by EPA Grant 97220700-0 to Cornell University as
part of the Great Lakes Restoration Initiative with supplemental funding
from the International Joint Commission. Further support was provided by
the agencies collaborating in the lower trophic level assessments of
Lake Ontario (EPA GNLPO and Region 2, NYSDEC, USGS, USFWS, DFO, EC,
OMNR). The opinions presented herein are those of the authors and do not
necessarily represent the position of EPA or USGS. This is contribution
number 1863 of the USGS Great Lakes Science Center.
NR 84
TC 6
Z9 6
U1 6
U2 34
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1463-4988
EI 1539-4077
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2015
VL 18
IS 1
BP 43
EP 62
DI 10.1080/14634988.2014.965121
PG 20
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CE3AI
UT WOS:000351695400006
ER
PT J
AU Xing, J
Mathur, R
Pleim, J
Hogrefe, C
Gan, CM
Wong, DC
Wei, C
Gilliam, R
Pouliot, G
AF Xing, J.
Mathur, R.
Pleim, J.
Hogrefe, C.
Gan, C-M.
Wong, D. C.
Wei, C.
Gilliam, R.
Pouliot, G.
TI Observations and modeling of air quality trends over 1990-2010 across
the Northern Hemisphere: China, the United States and Europe
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID MESOSCALE METEOROLOGICAL MODEL; BLACK CARBON CONCENTRATIONS; ATMOSPHERIC
BOUNDARY-LAYER; LINE OZONE CONCENTRATIONS; FINE PARTICULATE MATTER;
NONLOCAL CLOSURE-MODEL; LAND-SURFACE MODEL; LONG-TERM CHANGES; PART I;
PERFORMANCE EVALUATION
AB Trends in air quality across the Northern Hemisphere over a 21-year period (1990-2010) were simulated using the Community Multiscale Air Quality (CMAQ) multiscale chemical transport model driven by meteorology from Weather Research and Forecasting (WRF) simulations and internally consistent historical emission inventories obtained from EDGAR. Thorough comparison with several ground observation networks mostly over Europe and North America was conducted to evaluate the model performance as well as the ability of CMAQ to reproduce the observed trends in air quality over the past 2 decades in three regions: eastern China, the continental United States and Europe.
The model successfully reproduced the observed decreasing trends in SO2, NO2, 8 h O-3 maxima, SO42- and elemental carbon (EC) in the US and Europe. However, the model fails to reproduce the decreasing trends in NO3- in the US, potentially pointing to uncertainties of NH3 emissions. The model failed to capture the 6-year trends of SO2 and NO2 in CN-API (China - Air Pollution Index) from 2005 to 2010, but reproduced the observed pattern of O-3 trends shown in three World Data Centre for Greenhouse Gases (WDCGG) sites over eastern Asia. Due to the coarse spatial resolution employed in these calculations, predicted SO2 and NO2 concentrations are underestimated relative to all urban networks, i.e., US-AQS (US - ir Quality System; normalized mean bias (NMB) D 38% and 48 %), EU-AIRBASE (European Air quality data Base; NMB D 18 and 54 %) and CN-API (NMB D 36 and 68 %). Conversely, at the rural network EU-EMEP (European Monitoring and Evaluation Programme), SO2 is overestimated (NMB from 4 to 150 %) while NO2 is simulated well (NMB within +/- 15 %) in all seasons. Correlations between simulated and observed O-3 wintertime daily 8 h maxima (DM8) are poor compared to other seasons for all networks. Better correlation between simulated and observed SO42- was found compared to that for SO2. Underestimation of summer SO42- in the US may be associated with the uncertainty in precipitation and associated wet scavenging representation in the model. The model exhibits worse performance for NO3- predictions, particularly in summer, due to high uncertainties in the gas/particle partitioning of NO3- as well as seasonal variations of NH3 emissions. There are high correlations (R > 0.5) between observed and simulated EC, although the model underestimates the EC concentration by 65% due to the coarse grid resolution as well as uncertainties in the PM speciation profile associated with EC emissions.
The almost linear response seen in the trajectory of modeled O-3 changes in eastern China over the past 2 decades suggests that control strategies that focus on combined control of NOx and volatile organic compound (VOC) emissions with a ratio of 0.46 may provide the most effective means for O-3 reductions for the region devoid of nonlinear response potentially associated with NOx or VOC limitation resulting from alternate strategies. The response of O-3 is more sensitive to changes in NOx emissions in the eastern US because the relative abundance of biogenic VOC emissions tends to reduce the effectiveness of VOC controls. Increasing NH3 levels offset the relative effectiveness of NOx controls in reducing the relative fraction of aerosol NO3- formed from declining NOx emissions in the eastern US, while the control effectiveness was assured by the simultaneous control of NH3 emission in Europe.
C1 [Xing, J.; Mathur, R.; Pleim, J.; Hogrefe, C.; Gan, C-M.; Wong, D. C.; Wei, C.; Gilliam, R.; Pouliot, G.] US EPA, Durham, NC 27711 USA.
[Wei, C.] Max Planck Inst Chem, Multiphase Chem Dept, D-55128 Mainz, Germany.
RP Xing, J (reprint author), US EPA, Durham, NC 27711 USA.
EM xing.jia@epa.gov
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU US Department of Energy [DE-SC000378]; US EPA [RW-89-9233260 1];
National Research Council
FX Although this work has been reviewed and approved for publication by the
US Environmental Protection Agency (EPA), it does not reflect the views
and policies of the agency. This work was supported in part by an
inter-agency agreement between the US Department of Energy project (IA
no. DE-SC000378) and the US EPA (IA no. RW-89-9233260 1). This research
was performed while Jia Xing held a National Research Council Research
Associateship Award at the US EPA. The authors gratefully acknowledge
the free availability and use of data sets associated with the EDGAR,
SMOKE, GEIA, CASTNET, IMPROVE, AQS, EMEP, AIRBASE, WDCGG and China API
initiatives.
NR 80
TC 28
Z9 28
U1 20
U2 104
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 5
BP 2723
EP 2747
DI 10.5194/acp-15-2723-2015
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CD6KL
UT WOS:000351197900003
ER
PT J
AU Mukerjee, S
Smith, L
Brantley, H
Stallings, C
Neas, L
Kimbrough, S
Williams, R
AF Mukerjee, Shaibal
Smith, Luther
Brantley, Halley
Stallings, Casson
Neas, Lucas
Kimbrough, Sue
Williams, Ronald
TI Comparison of modeled traffic exposure zones using on-road air pollution
measurements
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Air pollution; geographic information system (GIS); mobile monitor;
traffic
ID NEAR-ROAD; RESIDENTIAL PROXIMITY; ULTRAFINE PARTICLES; MAJOR HIGHWAY;
QUALITY; ASTHMA; OUTCOMES; IMPACTS; TRENDS
AB Modeled traffic data were used to develop traffic exposure zones (TEZs) such as traffic delay, high volume, and transit routes in the Research Triangle area of North Carolina (USA). On-road air pollution measurements of nitrogen dioxide (NO2), carbon monoxide (CO), carbon dioxide (CO2), black carbon (BC), coarse (PM2.5-10), fine (PM2.5) particulate matter and ultrafine particles (UFPs) were made on routes that encountered these TEZs. Results indicated overall greater traffic pollutant levels in high volume and delay road sections than bus routes or areas of higher signal light density. The combination of delineating roadways into TEZs with highly time resolved on-road measurements demonstrated how pollutant levels can vary within roadways.
C1 [Mukerjee, Shaibal; Williams, Ronald] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Smith, Luther; Stallings, Casson] Alion Sci & Technol, Durham, NC USA.
[Brantley, Halley; Kimbrough, Sue] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Brantley, Halley] Student Serv Contractor, Res Triangle Pk, NC USA.
[Neas, Lucas] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Mukerjee, S (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM mukerjee.shaibal@epa.gov
OI Kimbrough, Evelyn Sue/0000-0002-7246-0255
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-D-10-070]
FX We thank the Institute for Transportation Research and Education at
North Carolina State University for providing modeled traffic counts and
Parikh Deshmukh of ARCADIS for field measurements. We also thank Gayle
Hagler, Carry Croghan, Jason Weinstein, and Eben Thoma of EPA/ORD for
analysis and reviewing the paper. The U.S. Environmental Protection
Agency through its Office of Research and Development funded and managed
the research described here under contract EP-D-10-070 to Alion. The
paper has been subjected to Agency review and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use.
NR 24
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PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD JAN
PY 2015
VL 6
IS 1
BP 82
EP 87
DI 10.5094/APR.2015.010
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE1AJ
UT WOS:000351543300010
ER
PT J
AU Jahne, MA
Rogers, SW
Ramler, IP
Holder, E
Hayes, G
AF Jahne, Michael A.
Rogers, Shane W.
Ramler, Ivan P.
Holder, Edith
Hayes, Gina
TI Hierarchal clustering yields insight into multidrug-resistant bacteria
isolated from a cattle feedlot wastewater treatment system
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Antibiotic resistance; Hierarchal clustering; Animal feeding operations;
Fecal indicator bacteria; Wastewater; Vancomycin
ID ANIMAL FEEDING OPERATIONS; GRAM-POSITIVE BACTERIA; ANTIMICROBIAL
RESISTANCE; ESCHERICHIA-COLI; VANCOMYCIN RESISTANCE;
ANTIBIOTIC-RESISTANCE; ENTEROCOCCUS-FAECALIS; SURFACE-WATER; HUMAN
HEALTH; GENE
AB Forty-two percent of Escherichia coli and 58 % of Enterococcus spp. isolated from cattle feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22 % of E. coli and 37 % of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant E. coli isolates that included cephalosporins (ceftiofur, cefoxitin, and ceftriaxone), aminoglycosides (gentamycin, kanamycin, and amikacin), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among vancomycin, linezolid, and daptomycin was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. Vancomycin resistance (n=49) only occurred when isolates were resistant to linezolid, daptomycin, and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested (tylosin, erythromycin, lincomycin, and quinipristin/dalfopristin). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and oxazolidinones may result in resistance to vancomycin as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health.
C1 [Jahne, Michael A.] Clarkson Univ, Inst Sustainable Environm, Potsdam, NY 13699 USA.
[Rogers, Shane W.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45212 USA.
[Ramler, Ivan P.] St Lawrence Univ, Dept Math Comp Sci & Stat, Canton, NY 13617 USA.
[Holder, Edith] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
[Hayes, Gina] Miami Univ, Inst Environm & Sustainabil, Oxford, OH 45056 USA.
RP Rogers, SW (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45212 USA.
EM srogers@clarkson.edu
FU National Research Initiative of the USDA Cooperative State Research,
Education, and Extension Service [2007-35102-18614]; U.S. Environmental
Protection Agency through its Office of Research and Development;
National Science Foundation [0959713]
FX This project was supported by the National Research Initiative of the
USDA Cooperative State Research, Education, and Extension Service, grant
number 2007-35102-18614. The U.S. Environmental Protection Agency,
through its Office of Research and Development, also funded and
collaborated in the research described herein. Any opinions expressed in
this paper are those of the authors and do not necessarily reflect the
official positions and policies of the USEPA. Any mention of trade names
or commercial products does not constitute endorsement or recommendation
for use. This material is based, in part, upon work supported by the
National Science Foundation under Grant No. 0959713. The authors thank
Dr. Robert Burns of Iowa State University for installation, calibration,
and maintenance of the sampling equipment and collection and shipment of
manure and water samples. The authors also thank the landowner who
graciously allowed access and collection of samples at the study site.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JAN
PY 2015
VL 187
IS 1
AR 4168
DI 10.1007/s10661-014-4168-9
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE0XU
UT WOS:000351535000001
PM 25504186
ER
PT J
AU Davis, AY
Ottmar, R
Liu, YQ
Goodrick, S
Achtemeier, G
Gullett, B
Aurell, J
Stevens, W
Greenwald, R
Hu, YT
Russell, A
Hiers, JK
Odman, MT
AF Davis, Aika Y.
Ottmar, Roger
Liu, Yongqiang
Goodrick, Scott
Achtemeier, Gary
Gullett, Brian
Aurell, Johanna
Stevens, William
Greenwald, Roby
Hu, Yongtao
Russell, Armistead
Hiers, J. Kevin
Odman, M. Talat
TI Fire emission uncertainties and their effect on smoke dispersion
predictions: a case study at Eglin Air Force Base, Florida, USA
SO INTERNATIONAL JOURNAL OF WILDLAND FIRE
LA English
DT Article
ID BIOMASS BURNING EMISSIONS; UNITED-STATES; PRESCRIBED BURNS; PLUME-RISE;
CARBON; URBAN; MODEL; SIMULATION; ATMOSPHERE; PARTICLES
AB Prescribed burning is practiced to benefit ecosystems but the resulting emissions can adversely affect air quality. A better understanding of the uncertainties in emission estimates and how these uncertainties affect smoke predictions is critical for model-based decision making. This study examined uncertainties associated with estimating fire emissions and how they affected smoke concentrations downwind from a prescribed burn that was conducted at Eglin Air Force Base in Florida, US. Estimated variables used in the modelled emission calculation were compared with field measurements. Fuel loadings, fuel consumption and emission factors were simulated using Photo Series, Consume, and previously published values. A plume dispersion model was used to study the effect of uncertainty in emissions on ground concentration prediction. The fire emission models predicted fuel loading, fuel consumption and emission factor within 15% of measurements. Approximately 18% uncertainty in field measurements of PM2.5 emissions and 36% uncertainty attributed to variability in emission estimating models resulted respectively in 20% and 42% ground level PM2.5 concentration uncertainties in dispersion modelling using Daysmoke. Uncertainty in input emissions influences the concentrations predicted by the smoke dispersion model to the same degree as does the model's inherent uncertainty due to turbulence.
C1 [Davis, Aika Y.; Hu, Yongtao; Russell, Armistead; Odman, M. Talat] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Ottmar, Roger] US Forest Serv, USDA, Pacific NW Res Stn, Pacific Wildland Fire Sci Lab, Seattle, WA 98103 USA.
[Liu, Yongqiang; Goodrick, Scott; Achtemeier, Gary] US Forest Serv, USDA, Southern Res Stn, Forestry Sci Lab, Athens, GA 30602 USA.
[Gullett, Brian; Aurell, Johanna] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Stevens, William] Kentucky Christian Univ, Grayson, KY 41143 USA.
[Greenwald, Roby] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Hiers, J. Kevin] Univ South, Environm Stewardship & Sustainabil, Sewanee, TN 37383 USA.
RP Odman, MT (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, 790 Atlantic Dr, Atlanta, GA 30332 USA.
EM talat.odman@ce.gatech.edu
RI Hu, Yongtao/H-7543-2016
OI Hu, Yongtao/0000-0002-5161-0592
FU Joint Fire Science Program [JFSP 081604, JFSP 081606]; Strategic
Environmental Research and Development Program [SERDP RC-1647]; NASA Air
Quality Applied Science Team [NNX11AI55G]; US EPA Science to Achieve
Results Program [RD83521701]
FX This study was made possible with support from the Joint Fire Science
Program (JFSP 081604 and JFSP 081606), the Strategic Environmental
Research and Development Program (SERDP RC-1647) and NASA Air Quality
Applied Science Team (NNX11AI55G). This publication was made possible
also by the US EPA Science to Achieve Results Program (RD83521701). Its
contents are solely the responsibility of the grantee and do not
necessarily represent the official views of the US EPA. Further, US EPA
does not endorse the purchase of any commercial products or services
mentioned in the publication. Special thanks are due to those who
participated in Rx-CADRE at Eglin AFB and helped gathering burn
information and data, especially Brett Williams from Jackson Guard,
Eglin AFB Fire Management, and Boris Galvis and Fernando Garcia-Menendez
from Georgia Institute of Technology. We also acknowledge David Combs
and Ken Forbus from USDA Forest Service for conduction ceilometer
measurements, as well as Chris Pressley, Bill Mitchell and Bill Squier
of EPA and Rob Gribble of ISSI Inc. for conducting aerostat
measurements.
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PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
3168, AUSTRALIA
SN 1049-8001
EI 1448-5516
J9 INT J WILDLAND FIRE
JI Int. J. Wildland Fire
PY 2015
VL 24
IS 2
BP 276
EP 285
DI 10.1071/WF13071
PG 10
WC Forestry
SC Forestry
GA CD9TX
UT WOS:000351442500014
ER
PT J
AU Moore, C
AF Moore, Chris
TI Welfare Estimates of Avoided Ocean Acidification in the US Mollusk
Market
SO JOURNAL OF AGRICULTURAL AND RESOURCE ECONOMICS
LA English
DT Article
DE compensating surplus; equivalent surplus; inverse demand system; ocean
acidification
ID INVERSE DEMAND SYSTEMS; DISTANCE FUNCTION; FISH; CO2
AB Ocean acidification has the potential to adversely affect a number of valuable marine ecosystem services by making it more difficult, and eventually impossible, for many marine organisms to form shells and skeletons. Reef-forming corals, commercially valuable shellfish, and primary producers that form the base of the marine food web are among the affected organisms. Despite the range and magnitude of likely impacts, very few economic analyses of ocean acidification's consequences have been conducted. This paper adds to the emerging body of literature by taking a distance function approach to estimating the benefits of avoided ocean acidification in the U.S. mollusk market. A nonlinear inverse almost ideal demand system estimates the utility parameters needed to calculate the exact consumer welfare measures compensating and equivalent surplus for two hypothetical policies that would reduce global greenhouse gas emissions relative to a business-as-usual scenario.
C1 US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Moore, C (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
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PU WESTERN AGRICULTURAL ECONOMICS ASSOC
PI LOGAN
PA C/O DEEVON BAILEY, UTAH STATE UNIV, ECONOMICS DEPT, 3535 OLD MAIN HILL,
LOGAN, UT 84322-3530 USA
SN 1068-5502
J9 J AGR RESOUR ECON
JI J. Agric. Resour. Econ.
PD JAN
PY 2015
VL 40
IS 1
BP 50
EP 62
PG 13
WC Agricultural Economics & Policy; Economics
SC Agriculture; Business & Economics
GA CE0EP
UT WOS:000351477600005
ER
PT J
AU Milovancev, M
Hauck, M
Keller, C
Stranahan, LW
Mansoor, A
Malarkey, DE
AF Milovancev, M.
Hauck, M.
Keller, C.
Stranahan, L. W.
Mansoor, A.
Malarkey, D. E.
TI Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of
Human Non-rhabdomyosarcoma Soft Tissue Sarcomas
SO JOURNAL OF COMPARATIVE PATHOLOGY
LA English
DT Article
DE comparative pathology; dog; man; soft tissue sarcoma
ID DRUG DEVELOPMENT; DOGS; TUMORS; TARGETS; BIOLOGY
AB Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other's interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Milovancev, M.] Oregon State Univ, Dept Clin Sci, Corvallis, OR 97331 USA.
[Hauck, M.; Stranahan, L. W.] N Carolina State Univ, Dept Clin Sci, Raleigh, NC 27695 USA.
[Keller, C.] Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, Pediat Canc Biol Program, Portland, OR 97201 USA.
[Mansoor, A.] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA.
[Malarkey, D. E.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA.
[Keller, C.] Childrens Canc Therapy Dev Inst, Ft Collins, CO 80524 USA.
RP Milovancev, M (reprint author), Oregon State Univ, Dept Clin Sci, Corvallis, OR 97331 USA.
EM milan.milovancev@oregonstate.edu
OI Milovancev, Milan/0000-0002-0556-4409
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9975
EI 1532-3129
J9 J COMP PATHOL
JI J. Comp. Pathol.
PD JAN
PY 2015
VL 152
IS 1
BP 22
EP 27
DI 10.1016/j.jcpa.2014.09.005
PG 6
WC Pathology; Veterinary Sciences
SC Pathology; Veterinary Sciences
GA CD2OX
UT WOS:000350920000004
PM 25435513
ER
PT J
AU Selvakumar, A
Matthews, JC
Condit, W
Sterling, R
AF Selvakumar, Ariamalar
Matthews, John C.
Condit, Wendy
Sterling, Ray
TI Innovative research program on the renewal of aging water infrastructure
systems
SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
LA English
DT Article
DE decision support; pipe rehabilitation; quality assurance/quality
control; trenchless technology; wastewater pipe; water pipe
ID REHABILITATION; SEWER; MAINS
AB The needs associated with the aging water infrastructure are immense and have been estimated at more than $1 trillion over the next 20 years for water and wastewater utilities. To meet this growing need, utilities require the use of innovative technologies and procedures for managing their systems. To help meet their needs, the U.S. Environmental Protection Agency initiated a research program to assist utilities in the renewal of water distribution and wastewater collection systems and this paper summarizes that program. This paper addresses the state-of-the-art review of current and emerging renewal technologies available for water distribution and wastewater collection systems. This paper also discusses the results of other program components which are intended to aid in the use of the renewal methods. This included: a cured-in-place pipe retrospective study of liners in use for more than 25 years; a field demonstration program of innovative water rehabilitation methods; a review of quality assurance and quality control measures for trenchless technologies; and current decision-making models and methodologies available to support rehabilitation versus replacement decisions.
C1 [Selvakumar, Ariamalar] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Urban Watershe, Edison, NJ 08837 USA.
[Matthews, John C.] Battelle Mem Inst, Baton Rouge, LA 70808 USA.
[Condit, Wendy] Battelle Mem Inst, Columbus, OH 43201 USA.
[Sterling, Ray] Louisiana Tech Univ, Ruston, LA 71272 USA.
RP Selvakumar, A (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Urban Watershe, 2890 Woodbridge Ave,MS-104, Edison, NJ 08837 USA.
EM selvakumar.ariamalar@epa.gov
OI Sterling, Raymond/0000-0003-0587-9459
FU U.S. EPA, through its Office of Research and Development
FX The U.S. EPA, through its Office of Research and Development, funded and
managed, or partially funded and collaborated in, the research described
herein. It has been subjected to the Agency's peer and administrative
review and has been approved for external publication. Any opinions
expressed in this paper are those of the authors and do not necessarily
reflect the views of the Agency, therefore, no official endorsement
should be inferred. Any mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0003-7214
EI 1365-2087
J9 J WATER SUPPLY RES T
JI J. Water Supply Res Technol.-Aqua
PY 2015
VL 64
IS 2
BP 117
EP 129
DI 10.2166/aqua.2014.103
PG 13
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA CC3XA
UT WOS:000350283300001
ER
PT J
AU Puchalski, MA
Rogers, CM
Baumgardner, R
Mishoe, KP
Price, G
Smith, MJ
Watkins, N
Lehmann, CM
AF Puchalski, Melissa A.
Rogers, Christopher M.
Baumgardner, Ralph
Mishoe, Kevin P.
Price, Garry
Smith, Michael J.
Watkins, Nealson
Lehmann, Christopher M.
TI A statistical comparison of active and passive ammonia measurements
collected at Clean Air Status and Trends Network (CASTNET) sites
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID UNITED-STATES; ATMOSPHERIC AMMONIA; AMBIENT AMMONIA; DRY DEPOSITION;
SULFUR-DIOXIDE; NITROGEN; MODEL; NH3; VEGETATION; EMISSIONS
AB Atmospheric concentrations of ammonia (NH3) are not well characterized in the United States due to the sparse number of monitors, the relatively short lifetime of NH3 in the atmosphere, and the difficulty in measuring non-point source emissions such as fertilized agricultural land. In this study, we compare measured weekly concentrations of NH3 collected by two denuder systems with a bi-weekly passive NH3 sampler used by the National Atmospheric Deposition Program's (NADP) Ammonia Monitoring Network (AMoN). The purpose of the study was to verify the passive samplers used by AMoN and characterize any uncertainties introduced when using a bi-weekly versus weekly sampling time period. The study was conducted for 1 year at five remote Clean Air Status and Trends Network (CASTNET) sites. Measured ambient NH3 concentrations ranged from 0.03 mu g NH3 m(-3) to 4.64 mu g NH3 m(-3) in upstate New York and northwest Texas, respectively, while dry deposition estimates ranged from 0.003 kg N ha(-1) wk(-1) to 0.47 kg N ha(-1) wk(-1). Results showed that the bi-weekly passive samplers performed well compared to annular denuder systems (ADS) deployed at each of the five CASTNET sites, while the MetOne Super SASS Mini-Parallel Plate Denuder System (MPPD) was biased low when compared to the ADS. The mean relative percent difference (MRPD) between the ADS and MPPD and the ADS and AMoN sampler was -38% and -9%, respectively. Precision of the ADS and MPPD was 5% and 13%, respectively, while the precision of the passive samplers was 5%. The results of this study demonstrate that the NH3 concentrations measured by AMoN are comparable to the ADS and may be used to supplement the high-time resolution measurements to gain information on spatial gradients of NH3, long-term trends and seasonal variations in NH3 concentrations.
C1 [Puchalski, Melissa A.] US EPA, Off Air Programs, Washington, DC 20460 USA.
[Rogers, Christopher M.; Mishoe, Kevin P.; Price, Garry; Smith, Michael J.] AMEC Environm & Infrastruct Inc, Newberry, FL 32669 USA.
[Baumgardner, Ralph] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Watkins, Nealson] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27709 USA.
[Lehmann, Christopher M.] Illinois State Water Survey, Cent Analyt Lab, Natl Atmospher Deposit Program, Champaign, IL 61820 USA.
RP Puchalski, MA (reprint author), US EPA, Off Air Programs, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM Puchalski.Melissa@epa.gov
FU U.S. Environmental Protection Agency through Office of Air Programs
[EP-W-09-028]; U.S. Environmental Protection Agency through Office of
Air Quality Planning and Standards [EP-W-09-028]; U.S. Environmental
Protection Agency through Office of Research and Development under EPA
[EP-W-09-028]
FX This work was funded by the U.S. Environmental Protection Agency through
its Office of Air Programs, Office of Air Quality Planning and
Standards, and Office of Research and Development under EPA contract
EP-W-09-028. This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 44
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U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 2
BP 358
EP 369
DI 10.1039/c4em00531g
PG 12
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CB5WM
UT WOS:000349698500011
PM 25574663
ER
PT J
AU Kulkarni, S
Sobhani, N
Miller-Schulze, JP
Shafer, MM
Schauer, JJ
Solomon, PA
Saide, PE
Spak, SN
Cheng, YF
van der Gon, HACD
Lu, Z
Streets, DG
Janssens-Maenhout, G
Wiedinmyer, C
Lantz, J
Artamonova, M
Chen, B
Imashev, S
Sverdlik, L
Deminter, JT
Adhikary, B
D'Allura, A
Wei, C
Carmichael, GR
AF Kulkarni, S.
Sobhani, N.
Miller-Schulze, J. P.
Shafer, M. M.
Schauer, J. J.
Solomon, P. A.
Saide, P. E.
Spak, S. N.
Cheng, Y. F.
van der Gon, H. A. C. Denier
Lu, Z.
Streets, D. G.
Janssens-Maenhout, G.
Wiedinmyer, C.
Lantz, J.
Artamonova, M.
Chen, B.
Imashev, S.
Sverdlik, L.
Deminter, J. T.
Adhikary, B.
D'Allura, A.
Wei, C.
Carmichael, G. R.
TI Source sector and region contributions to BC and PM2.5 in Central Asia
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID TERM CLIMATE-CHANGE; AIR-QUALITY; CARBONACEOUS AEROSOL; HUMAN HEALTH;
PLUME RISE; EMISSIONS; MODEL; DISTRIBUTIONS; TRANSPORT; INCLUSION
AB Particulate matter (PM) mass concentrations, seasonal cycles, source sector, and source region contributions in Central Asia (CA) are analyzed for the period April 2008-July 2009 using the Sulfur Transport and dEposition Model (STEM) chemical transport model and modeled meteorology from the Weather Research and Forecasting (WRF) model. Predicted aerosol optical depth (AOD) values (annual mean value similar to 0.2) in CA vary seasonally, with lowest values in the winter. Surface PM2.5 concentrations (annual mean value similar to 10 mu g m(3)) also exhibit a seasonal cycle, with peak values and largest variability in the spring/summer, and lowest values and variability in the winter (hourly values from 2 to 90 mu g m(3)). Surface concentrations of black carbon (BC) (mean value similar to 0.1 mu g m(-3)) show peak values in the winter. The simulated values are compared to surface measurements of AOD as well as PM2.5, PM10, BC, and organic carbon (OC) mass concentrations at two regional sites in Kyrgyzstan (Lidar Station Teplokluchenka (LST) and Bishkek). The predicted values of AOD and PM mass concentrations and their seasonal cycles are fairly well captured. The carbonaceous aerosols are underpredicted in winter, and analysis suggests that the winter heating emissions are underestimated in the current inventory.
Dust, from sources within and outside CA, is a significant component of the PM mass and drives the seasonal cycles of PM and AOD. On an annual basis, the power and industrial sectors are found to be the most important contributors to the anthropogenic portion of PM2.5. Residential combustion and transportation are shown to be the most important sectors for BC. Biomass burning within and outside the region also contributes to elevated PM and BC concentrations. The analysis of the transport pathways and the variations in particulate matter mass and composition in CA demonstrates that this region is strategically located to characterize regional and intercontinental transport of pollutants. Aerosols at these sites are shown to reflect dust, biomass burning, and anthropogenic sources from Europe; South, East, and Central Asia; and Russia depending on the time period.
Simulations for a reference 2030 emission scenario based on pollution abatement measures already committed to in current legislation show that PM2.5 and BC concentrations in the region increase, with BC growing more than PM2.5 on a relative basis. This suggests that both the health impacts and the climate warming associated with these particles may increase over the next decades unless additional control measures are taken. The importance of observations in CA to help characterize the changes that are rapidly taking place in the region are discussed.
C1 [Kulkarni, S.; Sobhani, N.; Saide, P. E.; Spak, S. N.; Cheng, Y. F.; Adhikary, B.; Wei, C.; Carmichael, G. R.] Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
[Sobhani, N.; Carmichael, G. R.] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA.
[Miller-Schulze, J. P.; Shafer, M. M.; Schauer, J. J.; Deminter, J. T.] Wisconsin State Lab Hyg, Madison, WI 53718 USA.
[Miller-Schulze, J. P.; Shafer, M. M.; Schauer, J. J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA.
[Solomon, P. A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA.
[Spak, S. N.; Lu, Z.] Univ Iowa, Publ Policy Ctr, Iowa City, IA 52242 USA.
[van der Gon, H. A. C. Denier] TNO, NL-3584 CB Utrecht, Netherlands.
[Streets, D. G.] Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA.
[Janssens-Maenhout, G.] European Commiss, Joint Res Ctr, IES, I-21027 Ispra, Italy.
[Wiedinmyer, C.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Lantz, J.] US EPA, Off Radiat & Indoor Air, Las Vegas, NV 89193 USA.
[Artamonova, M.] Russian Acad Sci, Inst Atmospher Phys, Moscow 109017, Russia.
[Chen, B.; Imashev, S.; Sverdlik, L.] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan.
[D'Allura, A.] ARIANET, I-20128 Milan, Italy.
RP Sobhani, N (reprint author), Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
EM negin-sobhani@uiowa.edu; gcarmich@engineering.uiowa.edu
RI Spak, Scott/B-7331-2008; wei, chao/E-4379-2011; Imashev,
Sanjar/I-7667-2016; Cheng, Yafang/F-9362-2010
OI Spak, Scott/0000-0002-8545-1411; Imashev, Sanjar/0000-0003-3293-3764;
Cheng, Yafang/0000-0003-4912-9879
FU US Environmental Protection Agency through its Office of Research and
Development; International Science & Technology Center (ISTC) [3715];
EPA [RD-83503701-0]; NASA [NNX08AH56G]; NSF [1049140]; NCRR
[UL1RR024979]; Fulbright-CONICYT [15093810]
FX The US Environmental Protection Agency through its Office of Research
and Development funded this study and collaborated in the research
described here as a component of the International Science & Technology
Center (ISTC) project no. 3715 (Transcontinental Transport of Air
Pollution from Central Asia to the US). The University of Iowa
activities were also supported in part by the following grants: EPA
(RD-83503701-0), NASA (NNX08AH56G), NSF (1049140), NCRR (UL1RR024979),
and Fulbright-CONICYT (15093810). The contents of this study are solely
the responsibility of the authors and do not necessarily represent the
official views of the funding institutions. This manuscript has been
subjected to US EPA review and approved for publication. We thank all
the PIs and their staff for establishing and maintaining the AERONET
sites that have been used in this study. We would also like to
acknowledge the Network Center for EANET and the EMEP Chemical
Coordinating Centre for the PM10 measurements used in this
study.
NR 39
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Z9 4
U1 3
U2 39
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 4
BP 1683
EP 1705
DI 10.5194/acp-15-1683-2015
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CB7IP
UT WOS:000349800500008
ER
PT J
AU Almand-Hunter, BB
Walker, JT
Masson, NP
Hafford, L
Hannigan, MP
AF Almand-Hunter, B. B.
Walker, J. T.
Masson, N. P.
Hafford, L.
Hannigan, M. P.
TI Development and validation of inexpensive, automated, dynamic flux
chambers
SO ATMOSPHERIC MEASUREMENT TECHNIQUES
LA English
DT Article
ID GASEOUS DRY DEPOSITION; NITRIC-OXIDE EMISSION; NITROGEN-DIOXIDE NO2;
AIR-QUALITY MODELS; GAS-EXCHANGE; MANAGEMENT STRATEGIES; REACTIVE
NITROGEN; OZONE FLUX; SURFACE; SOIL
AB We developed and validated an automated, inexpensive, and continuous multiple-species gas-flux monitoring system that can provide data for a variety of relevant atmospheric pollutants, including O-3, CO2, and NOx. Validation consisted of conducting concurrent gas-phase dry-deposition experiments, using both dynamic flux chambers and an eddy-covariance system, in a grassy clearing in the Duke Forest (Chapel Hill, NC). Experiments were carried out in June and September under a variety of meteorological conditions. Ozone-deposition measurements from the two methods matched very well (4-10% difference in mean flux rate) when the leaf-area index (LAI) inside the chambers was representative of the average LAI in the field. The dynamic flux chambers can be considered an accurate measurement system under these conditions.
C1 [Almand-Hunter, B. B.; Masson, N. P.; Hafford, L.; Hannigan, M. P.] Univ Colorado, Dept Mech Engn, Boulder, CO 80303 USA.
[Walker, J. T.] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Almand-Hunter, BB (reprint author), Univ Colorado, Dept Mech Engn, 427 UCB, Boulder, CO 80303 USA.
EM berkeley.almand@colorado.edu
FU Electric Power Research Institute (EPRI)
FX We are grateful for the opportunity to do this work, which was funded by
the Electric Power Research Institute (EPRI). We would like to thank
Corey Miller for his help building the flux chambers. We would like to
thank Peter Hamlington, Nick Clements, Bill Mitchell, and Andrew
Turnipseed for helpful discussions. This project would not have been
possible without equipment borrowed from Christine Wiedinmyer and John
Ortega, at the National Center for Atmospheric Research, as well as
Joanna Gordon and Ashley Collier. Ricardo Piedrahita and Nick Masson's
sensor work is the basis for the inexpensive sensor portion of this
project.
NR 55
TC 3
Z9 3
U1 4
U2 12
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1867-1381
EI 1867-8548
J9 ATMOS MEAS TECH
JI Atmos. Meas. Tech.
PY 2015
VL 8
IS 1
BP 267
EP 280
DI 10.5194/amt-8-267-2015
PG 14
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CA5WD
UT WOS:000348977600018
ER
PT J
AU Perez, CM
Hazari, MS
Farraj, AK
AF Perez, Christina M.
Hazari, Mehdi S.
Farraj, Aimen K.
TI Role of Autonomic Reflex Arcs in Cardiovascular Responses to Air
Pollution Exposure
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE C fibers; RARs; SARs; Baroreceptors; Carotid body; Air pollution
ID HEART-RATE-VARIABILITY; SPONTANEOUSLY HYPERTENSIVE-RATS; RESPIRATORY
SINUS ARRHYTHMIA; RAPIDLY ADAPTING RECEPTORS; INFANT-DEATH-SYNDROME;
BAROREFLEX SENSITIVITY; PARTICULATE MATTER; BLOOD-PRESSURE;
CAROTID-BODY; MYOCARDIAL-INFARCTION
AB The body responds to environmental stressors by triggering autonomic reflexes in the pulmonary receptors, baroreceptors, and chemoreceptors to maintain homeostasis. Numerous studies have shown that exposure to various gases and airborne particles can alter the functional outcome of these reflexes, particularly with respect to the cardiovascular system. Modulation of autonomic neural input to the heart and vasculature following direct activation of sensory nerves in the respiratory system, elicitation of oxidative stress and inflammation, or through other mechanisms is one of the primary ways that exposure to air pollution affects normal cardiovascular function. Any homeostatic process that utilizes the autonomic nervous system to regulate organ function might be affected. Thus, air pollution and other inhaled environmental irritants have the potential to alter both local airway function and baro- and chemoreflex responses, which modulate autonomic control of blood pressure and detect concentrations of key gases in the body. While each of these reflex pathways causes distinct responses, the systems are heavily integrated and communicate through overlapping regions of the brainstem to cause global effects. This short review summarizes the function of major pulmonary sensory receptors, baroreceptors, and carotid body chemoreceptors and discusses the impacts of air pollution exposure on these systems.
C1 [Perez, Christina M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Hazari, Mehdi S.; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
RP Perez, CM (reprint author), Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
EM clamb@email.unc.edu
FU NIEHS NIH HHS [T32 ES007126]
NR 104
TC 6
Z9 6
U1 1
U2 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD JAN
PY 2015
VL 15
IS 1
BP 69
EP 78
DI 10.1007/s12012-014-9272-0
PG 10
WC Cardiac & Cardiovascular Systems; Toxicology
SC Cardiovascular System & Cardiology; Toxicology
GA CB1UA
UT WOS:000349412300008
PM 25123706
ER
PT J
AU Baig, RBN
Vaddula, BR
Nadagouda, MN
Varma, RS
AF Baig, R. B. Nasir
Vaddula, Buchi Reddy
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI The copper-nicotinamide complex: sustainable applications in coupling
and cycloaddition reactions
SO GREEN CHEMISTRY
LA English
DT Article
ID RECYCLABLE HETEROGENEOUS CATALYST; ARYL HALIDES; SUPPORTED COPPER;
NICKEL-CATALYST; BOND FORMATION; C-N; POTENT; CHEMISTRY; PALLADIUM;
CHITOSAN
AB The crystalline copper(II)-nicotinamide complex, synthesized via simple mixing of copper chloride and nicotinamide solution at room temperature, catalyzes the C-S, C-N bond forming and cycloaddition reactions under a variety of sustainable reaction conditions.
C1 [Baig, R. B. Nasir; Vaddula, Buchi Reddy; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Nadagouda, Mallikarjuna N.] US EPA, WQMB, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Baig, RBN (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM nadagouda.mallikarjuna@epa.gov; Varma.Rajender@epa.gov
FU appointment to the Research Participation Program for the U.S.
Environmental Protection Agency, Office of Research and Development
FX R. B. Nasir Baig and B. R. Vaddula were supported in part by an
appointment to the Research Participation Program for the U.S.
Environmental Protection Agency, Office of Research and Development,
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and the EPA.
NR 37
TC 4
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U1 2
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 2
BP 1243
EP 1248
DI 10.1039/c4gc02047b
PG 6
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CB0KQ
UT WOS:000349315200067
ER
PT J
AU Wood, JP
Clayton, MJ
McArthur, T
Serre, SD
Mickelsen, L
Touati, A
AF Wood, Joseph P.
Clayton, Mathew J.
McArthur, Timothy
Serre, Shannon D.
Mickelsen, Leroy
Touati, Abderrahmane
TI Capture of methyl bromide emissions with activated carbon following the
fumigation of a small building contaminated with a Bacillus anthracis
spore simulant
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID ADSORPTION
AB A wide-area Bacillus anthracis spore contamination incident will present immense challenges related to decontamination capacity. For this reason, fumigation with methyl bromide (MeBr) has been proposed as a potential remediation option. Although a few bench-scale laboratory studies have been conducted to evaluate activated carbon for the capture of MeBr, these studies were conducted at conditions replicating commodity fumigation using relatively low MeBr concentrations, temperatures, and/or relative humidity (RH) levels. The more rigorous MeBr fumigation requirements to fully inactivate B. anthracis spores are much more of a challenge for an activated carbon system (ACS) to capture MeBr, and warrant their own investigation. Further, while the aforementioned studies have shown activated carbon to be a possible option for the capture of MeBr in gas streams, these tests were conducted at laboratory bench scale, and thus lack operational perspective and data. Thus, we present for the first time the results of a full-scale study to evaluate an ACS employed for the capture of MeBr at conditions that would be used for decontaminating a building structure contaminated with B. anthracis spores. Airflow rate, temperature, RH, and MeBr levels were measured within the ACS during its operation. Despite the relatively high humidity, temperature, and MeBr levels, the MeBr capture efficiency of the ACS was demonstrated to be more than 99%. The concentration of MeBr exhausted from the structure was reduced from 41,000 to 136 ppmv in 3.5 hr, corresponding to an overall atmospheric emission rate of less than 2 kg. The practical adsorption rate of the ACS was determined to be 4.83 kg MeBr/100 kg carbon. The information and data presented here will facilitate future use of this technology when fumigating with MeBr.
C1 [Wood, Joseph P.; Serre, Shannon D.; Mickelsen, Leroy] US EPA, Res Triangle Pk, NC 27711 USA.
[Clayton, Mathew J.; McArthur, Timothy; Touati, Abderrahmane] ARCADIS US Inc, Durham, NC USA.
RP Wood, JP (reprint author), US EPA, 109 TW Alexander Dr,MC E343-06, Res Triangle Pk, NC 27711 USA.
EM wood.joe@epa.gov
OI Wood, Joseph/0000-0001-6316-9418
FU U.S. Environmental Protection Agency, through its Office of Research and
Development's National Homeland Security Research Center [EP-C-09-027];
ARCADIS US, Inc.
FX The U.S. Environmental Protection Agency, through its Office of Research
and Development's National Homeland Security Research Center, funded and
directed this work through contract EP-C-09-027 with ARCADIS US, Inc.
NR 14
TC 2
Z9 2
U1 2
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 2
BP 145
EP 153
DI 10.1080/10962247.2014.980017
PG 9
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CA2KP
UT WOS:000348737800004
PM 25947050
ER
PT J
AU Gocht, T
Berggren, E
Ahr, HJ
Cotgreave, I
Cronin, MTD
Daston, G
Hardy, B
Heinzle, E
Hescheler, J
Knight, DJ
Mahony, C
Peschanski, M
Schwarz, M
Thomas, RS
Verfaillie, C
White, A
Whelan, M
AF Gocht, Tilman
Berggren, Elisabet
Ahr, Hans Juergen
Cotgreave, Ian
Cronin, Mark T. D.
Daston, George
Hardy, Barry
Heinzle, Elmar
Hescheler, Juergen
Knight, Derek J.
Mahony, Catherine
Peschanski, Marc
Schwarz, Michael
Thomas, Russell S.
Verfaillie, Catherine
White, Andrew
Whelan, Maurice
TI The SEURAT-1 Approach towards Animal Free Human Safety Assessment
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE alternatives to animal testing; integrated testing strategy;
mode-of-action theory; proof-of-concept case studies; safety assessment
ID INTEGRATED TESTING STRATEGIES; ALTERNATIVE NONANIMAL METHODS; ADVERSE
OUTCOME PATHWAYS; STRESS-RESPONSE PATHWAYS; RISK-ASSESSMENT;
READ-ACROSS; IN-VITRO; TOXICITY; TOXICOLOGY; FRAMEWORK
AB SEURAT-1 is a European public-private research consortium that is working towards animal-free testing of chemical compounds and the highest level of consumer protection. A research strategy was formulated based on the guiding principle to adopt a toxicological mode-of-action framework to describe how any substance may adversely affect human health. The proof of the initiative will be in demonstrating the applicability of the concepts on which SEURAT-1 is built on three levels: (i) Theoretical prototypes for adverse outcome pathways are formulated based on knowledge already available in the scientific literature on investigating the toxicological modes-of-action leading to adverse outcomes (addressing mainly liver toxicity); (ii) adverse outcome pathway descriptions are used as a guide for the formulation of case studies to further elucidate the theoretical model and to develop integrated testing strategies for the prediction of certain toxicological effects (i.e., those related to the adverse outcome pathway descriptions); (iii) further case studies target the application of knowledge gained within SEURAT-1 in the context of safety assessment. The ultimate goal would be to perform ab initio predictions based on a complete understanding of toxicological mechanisms. In the near-term, it is more realistic that data from innovative testing methods will support read-across arguments. Both scenarios are addressed with case studies for improved safety assessment. A conceptual framework for a rational integrated assessment strategy emerged from designing the case studies and is discussed in the context of international developments focusing on alternative approaches for evaluating chemicals using the new 21st century tools for toxicity testing.
C1 [Gocht, Tilman; Schwarz, Michael] Univ Tubingen, Univ Hosp, Inst Expt & Clin Pharmacol & Toxicol, D-72074 Tubingen, Germany.
[Berggren, Elisabet; Whelan, Maurice] IHCP, JRC, European Commiss, Ispra, Italy.
[Berggren, Elisabet; Whelan, Maurice] EU Reference Lab Alternat Anim Testing EURL ECVAM, Ispra, Italy.
[Ahr, Hans Juergen] Bayer AG, Dept Mol & Genet Toxicol, Wuppertal, Germany.
[Cotgreave, Ian] Swedish Toxicol Sci, Res Ctr Swetox, Sodertalje, Sweden.
[Cotgreave, Ian] Karolinska Inst, Inst Environm Med, Solna, Sweden.
[Cronin, Mark T. D.] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England.
[Daston, George] Procter & Gamble, Product Safety & Regulatory Affairs, Cincinnati, OH USA.
[Hardy, Barry] Douglas Connect, Zeiningen, Switzerland.
[Heinzle, Elmar] Univ Saarland, Saarbrucken, Germany.
[Hescheler, Juergen] Univ Hosp Cologne, Inst Neurophysiol, Cologne, Germany.
[Knight, Derek J.] European Chem Agcy, Helsinki, Finland.
[Mahony, Catherine] Procter & Gamble, Cent Product Safety Dept, London, England.
[Peschanski, Marc] I STEM AFM, INSERM UEVE 861, Evry, France.
[Thomas, Russell S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Verfaillie, Catherine] Katholieke Univ Leuven, Interdept Stem Cell Inst, Leuven, Belgium.
[White, Andrew] Unilever, Safety & Environm Assurance Ctr, Bedford, England.
RP Gocht, T (reprint author), Univ Tubingen, Univ Hosp, Inst Expt & Clin Pharmacol & Toxicol, Wilhelmstr 56, D-72074 Tubingen, Germany.
EM tilman.gocht@uni-tuebingen.de
OI Thomas, Russell/0000-0002-2340-0301; Gocht, Tilma/0000-0002-2491-2050
FU European Community's Seventh Framework Programme (FP7) (project acronym
"COACH") [267044]; Cosmetics Europe; Open Access Publishing Fund of
Tubingen University
FX This research work has received funding from the European Community's
Seventh Framework Programme (FP7/2007-2013) under grant agreement no
267044 (project acronym "COACH"), and has received financing from
Cosmetics Europe. We acknowledge support by the Open Access Publishing
Fund of Tubingen University.
NR 57
TC 8
Z9 8
U1 2
U2 12
PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
PI HEILDEBERG
PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY
SN 1868-596X
EI 1868-8551
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2015
VL 32
IS 1
BP 9
EP 24
PG 16
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CA5QM
UT WOS:000348962900003
PM 25372315
ER
PT J
AU Leet, JK
Sassman, S
Amberg, JJ
Olmstead, AW
Lee, LS
Ankley, GT
Sepulveda, MS
AF Leet, Jessica K.
Sassman, Stephen
Amberg, Jon J.
Olmstead, Allen W.
Lee, Linda S.
Ankley, Gerald T.
Sepulveda, Maria S.
TI Environmental hormones and their impacts on sex differentiation in
fathead minnows
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Estrogens; Androgens; Atrazine; Animal feeding operations; Pimephales
promelas
ID ANIMAL FEEDING OPERATIONS; EARLY-LIFE-STAGES; PIMEPHALES-PROMELAS;
REPRODUCTIVE ENDOCRINOLOGY; RELEVANT CONCENTRATIONS; ESTROGENIC
CHEMICALS; STEROIDAL ESTROGENS; GENE-EXPRESSION; RAINBOW-TROUT; FISH
AB Runoff from lands fertilized with animal manure from concentrated animal feeding operations (CAFOs) is a source of hormones to surface water. In this study we tested the hypothesis that larval fathead minnows exposed to sex steroids singly or in a "typical" CAFO mixture during sex differentiation would respond with changes in the expression of a set of target genes, leading to gonadal abnormalities later in life. In the first experiment, a static daily-renewal system was used to expose larvae during the period of 10-20 days post-hatch (dph) to either 5 ng/L 17 beta-trenbolone (17 beta-TRB) or 5 ng/L 17 alpha-ethinylestradiol (EE2). In a second experiment, fish were exposed from 0 to 45 dph in a flow-through system to a CAFO mixture composed of steroids and degradates (2-16 ng/L), atrazine and degradates (15-250 ng/L), and nitrate (3-11 mg/L). In the single hormone experiment, expression of genes involved in steroidogenesis (cyp19a, cyp17, and star) was decreased in females. In contrast, no differences in gene expression were observed in fish exposed to the CAFO mixture. However, the majority (84%) of treated males had testes containing an ovarian cavity, indicative of feminization, compared to 0% in the control males. Overall, our results show that: (1) changes in gene expression after single hormone exposures are sex-specific, with females more responsive than males; and (2) phenotypic alterations in testicular development can be elicited by a simulated "CAFO" mixture when fathead minnows are exposed during the first 45 days of development. More research is needed to further discern the complex response of fish to steroid mixtures, especially those associated with runoff from land-applied CAFO waste. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Leet, Jessica K.; Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA.
[Sassman, Stephen; Lee, Linda S.] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
[Amberg, Jon J.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA.
[Olmstead, Allen W.] Bayer Crop Sci, Environm Toxicol & Risk Assessment, Res Triangle Pk, NC 27709 USA.
[Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Sepulveda, MS (reprint author), 195 Marsteller St, W Lafayette, IN 47907 USA.
EM jleet@mailbox.sc.edu; sassman@purdue.edu; Islee@purdue.edu;
jamberg@usgs.gov; allen.olmstead@bayer.com; ankley.gerald@epa.gov;
mssepulv@purdue.edu
RI Sepulveda, Maria/P-3598-2014
FU USEPA STAR [RD833417]; assistantship from the Department of Forestry and
Natural Resources, Purdue University
FX Funding was provided by USEPA STAR (RD833417). The lead author (JKL) was
supported by an assistantship from the Department of Forestry and
Natural Resources, Purdue University. We thank Bob Rode for his help in
various aspects of these studies.
NR 34
TC 7
Z9 7
U1 10
U2 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN
PY 2015
VL 158
BP 98
EP 107
DI 10.1016/j.aquatox.2014.10.022
PG 10
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA CA4PZ
UT WOS:000348888400011
PM 25671225
ER
PT J
AU Aluru, N
Karchner, SI
Franks, DG
Nacci, D
Champlin, D
Hahn, ME
AF Aluru, Neelakanteswar
Karchner, Sibel I.
Franks, Diana G.
Nacci, Diane
Champlin, Denise
Hahn, Mark E.
TI Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in
Atlantic killifish (Fundulus heteroclitus)
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Non-model organisms; Gene knock-outs; Mummichog; Adaptation; Zinc finger
nucleases; CRISPR-Cas9
ID ZINC-FINGER NUCLEASES; TAL EFFECTOR NUCLEASES; XENOPUS-TROPICALIS;
IN-VIVO; ENVIRONMENTAL CONTAMINANTS; CIONA-INTESTINALIS; EFFICIENT;
GENOME; DISRUPTION; ZEBRAFISH
AB Understanding molecular mechanisms of toxicity is facilitated by experimental manipulations, such as disruption of function by gene targeting, that are especially challenging in non-standard model species with limited genomic resources. While loss-of-function approaches have included gene knock-down using morpholino-modified oligonucleotides and random mutagenesis using mutagens or retroviruses, more recent approaches include targeted mutagenesis using zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology. These latter methods provide more accessible opportunities to explore gene function in non-traditional model species. To facilitate evaluation of toxic mechanisms for important categories of aryl hydrocarbon pollutants, whose actions are known to be receptor mediated, we used ZFN and CRISPR-Cas9 approaches to generate aryl hydrocarbon receptor 2a (AHR2a) and AHR2b gene mutations in Atlantic killifish (Fundulus heteroclitus) embryos. This killifish is a particularly valuable non-traditional model, with multiple paralogs of AHR whose functions are not well characterized. In addition, some populations of this species have evolved resistance to toxicants such as halogenated aromatic hydrocarbons. AHR-null killifish will be valuable for characterizing the role of the individual AHR paralogs in evolved resistance, as well as in normal development. We first used five-finger ZFNs targeting exons 1 and 3 of AHR2a. Subsequently, CRISPR-Cas9 guide RNAs were designed to target regions in exon 2 and 3 of AHR2a and AHR2b. We successfully induced frameshift mutations in AHR2a exon 3 with ZFN and CRISPR-Cas9 guide RNAs, with mutation frequencies of 10% and 16%, respectively. In AHR2b, mutations were induced using CRISPR-Cas9 guide RNAs targeting sites in both exon 2 (17%) and exon 3 (63%). We screened AHR2b exon 2 CRISPR-Cas9-injected embryos for off-target effects in AHR paralogs. No mutations were observed in closely related AHR genes (AHR1a, AHR1b,AHR2a, AHRR) in the CRISPR-Cas9-injected embryos. Overall, our results demonstrate that targeted genome-editing methods are efficient in inducing mutations at specific loci in embryos of a non-traditional model species, without detectable off-target effects in paralogous genes. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Aluru, Neelakanteswar; Karchner, Sibel I.; Franks, Diana G.; Hahn, Mark E.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA.
[Aluru, Neelakanteswar; Karchner, Sibel I.; Franks, Diana G.; Hahn, Mark E.] Boston Univ, Sch Publ Hlth, Superfund Res Program, Boston, MA USA.
[Nacci, Diane; Champlin, Denise] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA.
RP Aluru, N (reprint author), Woods Hole Oceanog Inst, Dept Biol, Redfield Bldg,MS 32,45 Water St, Woods Hole, MA 02543 USA.
EM nalurn@whoi.edu
OI Hahn, Mark/0000-0003-4358-2082
FU National Institute of Environmental Health Sciences (NIEHS) (Superfund
Research Program at Boston University) [P42ES007381]; Andrew W. Mellon
Foundation Award for Innovative Research; National Science Foundation
[DEB-1120512, DEB-1265282, DEB-1120013, DEB-1120263, DEB-1120333,
DEB-1120398]
FX This work was supported by National Institute of Environmental Health
Sciences (NIEHS) grant P42ES007381 (Superfund Research Program at Boston
University) and by an Andrew W. Mellon Foundation Award for Innovative
Research to MEH. Design of guide RNAs and primers was aided by reference
to a preliminary draft of the F. heteroclitus genome sequence, which was
supported by funding from the National Science Foundation (collaborative
research grants DEB-1120512, DEB-1265282, DEB-1120013, DEB-1120263,
DEB-1120333, DEB-1120398). We also acknowledge the help provided by Ms.
Kathryn Crawford in fish collection and embryo rearing.
NR 93
TC 7
Z9 7
U1 1
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN
PY 2015
VL 158
BP 192
EP 201
DI 10.1016/j.aquatox.2014.11.016
PG 10
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA CA4PZ
UT WOS:000348888400021
PM 25481785
ER
PT J
AU Kwok, RHF
Baker, KR
Napelenok, SL
Tonnesen, GS
AF Kwok, R. H. F.
Baker, K. R.
Napelenok, S. L.
Tonnesen, G. S.
TI Photochemical grid model implementation and application of VOC, NOx, and
O-3 source apportionment
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID VOLATILE ORGANIC-COMPOUNDS; RADICAL PROPAGATION EFFICIENCY; SURFACE
OZONE CONCENTRATIONS; AIR-QUALITY MODELS; UNITED-STATES; SOURCE
IDENTIFICATION; EMISSION INVENTORY; NITROGEN-OXIDES; NORTH-AMERICA;
SENSITIVITY
AB For the purposes of developing optimal emissions control strategies, efficient approaches are needed to identify the major sources or groups of sources that contribute to elevated ozone (O-3) concentrations. Source-based apportionment techniques implemented in photochemical grid models track sources through the physical and chemical processes important to the formation and transport of air pollutants. Photochemical model source apportionment has been used to track source impacts of specific sources, groups of sources (sectors), sources in specific geographic areas, and stratospheric and lateral boundary inflow on O-3. The implementation and application of a source apportionment technique for O-3 and its precursors, nitrogen oxides (NOx) and volatile organic compounds (VOCs), for the Community Multiscale Air Quality (CMAQ) model are described here. The Integrated Source Apportionment Method (ISAM) O-3 approach is a hybrid of source apportionment and source sensitivity in that O-3 production is attributed to precursor sources based on O-3 formation regime (e.g., for a NOx-sensitive regime, O-3 is apportioned to participating NOx emissions). This implementation is illustrated by tracking multiple emissions source sectors and lateral boundary inflow. NOx, VOC, and O-3 attribution to tracked sectors in the application are consistent with spatial and temporal patterns of precursor emissions. The O-3 ISAM implementation is further evaluated through comparisons of apportioned ambient concentrations and deposition amounts with those derived from brute force zero-out scenarios, with correlation coefficients ranging between 0.58 and 0.99 depending on specific combination of target species and tracked precursor emissions. Low correlation coefficients occur for chemical regimes that have strong nonlinearity in O-3 sensitivity, which demonstrates different functionalities between source apportionment and zero-out approaches, where appropriate use depends on whether source attribution or source sensitivity is desired.
C1 [Kwok, R. H. F.; Baker, K. R.; Napelenok, S. L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Tonnesen, G. S.] US EPA, Denver, CO 80202 USA.
RP Napelenok, SL (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM napelenok.sergey@epa.gov
NR 67
TC 10
Z9 10
U1 9
U2 53
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 1
BP 99
EP 114
DI 10.5194/gmd-8-99-2015
PG 16
WC Geosciences, Multidisciplinary
SC Geology
GA CA5WK
UT WOS:000348978400007
ER
PT J
AU Zhao, B
Wang, SX
Xing, J
Fu, K
Fu, JS
Jang, C
Zhu, Y
Dong, XY
Gao, Y
Wu, WJ
Wang, JD
Hao, JM
AF Zhao, B.
Wang, S. X.
Xing, J.
Fu, K.
Fu, J. S.
Jang, C.
Zhu, Y.
Dong, X. Y.
Gao, Y.
Wu, W. J.
Wang, J. D.
Hao, J. M.
TI Assessing the nonlinear response of fine particles to precursor
emissions: development and application of an extended response surface
modeling technique v1.0
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID ADJOINT SENSITIVITY-ANALYSIS; YANGTZE-RIVER DELTA; AIR-QUALITY MODELS;
PHOTOCHEMICAL MODELS; INORGANIC AEROSOLS; CONTROL STRATEGIES; OZONE
CONTROL; HIGH-ORDER; CHINA; POLLUTION
AB An innovative extended response surface modeling technique (ERSM v1.0) is developed to characterize the nonlinear response of fine particles (PM2.5) to large and simultaneous changes of multiple precursor emissions from multiple regions and sectors. The ERSM technique is developed based on the conventional response surface modeling (RSM) technique; it first quantifies the relationship between PM2.5 concentrations and the emissions of gaseous precursors from each single region using the conventional RSM technique, and then assesses the effects of inter-regional transport of PM2.5 and its gaseous precursors on PM2.5 concentrations in the target region. We apply this novel technique with a widely used regional chemical transport model (CTM) over the Yangtze River delta (YRD) region of China, and evaluate the response of PM2.5 and its inorganic components to the emissions of 36 pollutant-region-sector combinations. The predicted PM2.5 concentrations agree well with independent CTM simulations; the correlation coefficients are larger than 0.98 and 0.99, and the mean normalized errors (MNEs) are less than 1 and 2% for January and August, respectively. It is also demonstrated that the ERSM technique could reproduce fairly well the response of PM2.5 to continuous changes of precursor emission levels between zero and 150 %. Employing this new technique, we identify the major sources contributing to PM2.5 and its inorganic components in the YRD region. The nonlinearity in the response of PM2.5 to emission changes is characterized and the underlying chemical processes are illustrated.
C1 [Zhao, B.; Wang, S. X.; Fu, K.; Wu, W. J.; Wang, J. D.; Hao, J. M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Wang, S. X.; Hao, J. M.] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Xing, J.; Jang, C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Fu, J. S.; Dong, X. Y.; Gao, Y.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Zhu, Y.] S China Univ Technol, Sch Environm Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China.
[Gao, Y.] Pacific NW Natl Lab, Atmospher Sci & Global Change Div, Richland, WA 99352 USA.
RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI xing, jia/O-1784-2014; wang, shuxiao/H-5990-2011
OI wang, shuxiao/0000-0001-9727-1963
FU National Natural Science Foundation of China [21221004]; Strategic
Priority Research Program of the Chinese Academy of Sciences
[XBD05020300]; MEP's Special Funds for Research on Public Welfares
[201409002, 201309009]; Collaborative Innovation Center for Regional
Environmental Quality of Tsinghua University
FX This work was sponsored by National Natural Science Foundation of China
(21221004), Strategic Priority Research Program of the Chinese Academy
of Sciences (XBD05020300), and MEP's Special Funds for Research on
Public Welfares (201409002, 201309009). The authors also appreciate the
support from Collaborative Innovation Center for Regional Environmental
Quality of Tsinghua University. Our work was completed on the Explorer
100 cluster system of Tsinghua National Laboratory for Information
Science and Technology.
NR 38
TC 8
Z9 8
U1 2
U2 28
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 1
BP 115
EP 128
DI 10.5194/gmd-8-115-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CA5WK
UT WOS:000348978400008
ER
PT J
AU Fischer, BM
Voynow, JA
Ghio, AJ
AF Fischer, Bernard M.
Voynow, Judith A.
Ghio, Andrew J.
TI COPD: balancing oxidants and antioxidants
SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
LA English
DT Review
DE cigarette smoking; mucins; gene regulation; Chinese herbs; acupuncture;
dietary antioxidants
ID OBSTRUCTIVE PULMONARY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; NUTRITION
EXAMINATION SURVEY; INCREASED OXIDATIVE STRESS; EXHALED BREATH
CONDENSATE; SMALL-AIRWAY OBSTRUCTION; GENOME-WIDE ASSOCIATION; GOBLET
CELL METAPLASIA; RETINOL EFFICACY TRIAL; 3RD NATIONAL-HEALTH
AB Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental exposures, primarily cigarette smoking. Since only a small subset of smokers develop COPD, it is believed that host factors interact with the environment to increase the propensity to develop disease. The major pathogenic factors causing disease include infection and inflammation, protease and antiprotease imbalance, and oxidative stress overwhelming antioxidant defenses. In this review, we will discuss the major environmental and host sources for oxidative stress; discuss how oxidative stress regulates chronic bronchitis; review the latest information on genetic predisposition to COPD, specifically focusing on oxidant/antioxidant imbalance; and review future antioxidant therapeutic options for COPD. The complexity of COPD will necessitate a multi-target therapeutic approach. It is likely that antioxidant supplementation and dietary antioxidants will have a place in these future combination therapies.
C1 [Fischer, Bernard M.] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA.
[Voynow, Judith A.] Virginia Commonwealth Univ, Childrens Hosp Richmond, Dept Pediat, Richmond, VA USA.
[Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Fischer, BM (reprint author), Duke Univ, Med Ctr, Dept Pediat, Box 103201, Durham, NC 27710 USA.
EM bernie.fischer@duke.edu
NR 169
TC 6
Z9 6
U1 2
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2005
J9 INT J CHRONIC OBSTR
JI Int. J. Chronic Obstr. Pulm. Dis.
PY 2015
VL 10
DI 10.2147/COPD.S42414
PG 16
WC Respiratory System
SC Respiratory System
GA CA2JN
UT WOS:000348734800001
ER
PT J
AU Zhu, Y
Lao, YW
Jang, C
Lin, CJ
Xing, J
Wang, SX
Fu, JS
Deng, S
Xie, JP
Long, SC
AF Zhu, Yun
Lao, Yanwen
Jang, Carey
Lin, Chen-Jen
Xing, Jia
Wang, Shuxiao
Fu, Joshua S.
Deng, Shuang
Xie, Junping
Long, Shicheng
TI Development and case study of a science-based software platform to
support policy making on air quality
SO JOURNAL OF ENVIRONMENTAL SCIENCES
LA English
DT Article
DE Air quality; Policy making; Response surface modeling; Emission control
scenarios; Data visualization
ID CHINA; SYSTEM; MODEL; IMPACT
AB This article describes the development and implementations of a novel software platform that supports real-time, science-based policy making on air quality through a user-friendly interface. The software, RSM-VAT, uses a response surface modeling (RSM) methodology and serves as a visualization and analysis tool (VAT) for three-dimensional air quality data obtained by atmospheric models. The software features a number of powerful and intuitive data visualization functions for illustrating the complex nonlinear relationship between emission reductions and air quality benefits. The case study of contiguous U.S. demonstrates that the enhanced RSM-VAT is capable of reproducing the air quality model results with Normalized Mean Bias <2% and assisting in air quality policy making in near real time. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
C1 [Zhu, Yun; Lin, Chen-Jen] S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China.
[Zhu, Yun; Xing, Jia; Wang, Shuxiao] Tsinghua Univ, Sch Environm, State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Lao, Yanwen; Xie, Junping; Long, Shicheng] S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangzhou 510006, Guangdong, Peoples R China.
[Jang, Carey] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Lin, Chen-Jen] Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA.
[Fu, Joshua S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Deng, Shuang] Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China.
RP Zhu, Y (reprint author), S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China.
EM zhuyun@scut.edu.cn
RI xing, jia/O-1784-2014; wang, shuxiao/H-5990-2011; Lin,
Che-Jen/K-1808-2013
OI wang, shuxiao/0000-0001-9727-1963; Lin, Che-Jen/0000-0001-5990-3093
FU U.S. Environmental Protection Agency [GS-10F-0205T]; Guangdong
Provincial Key Laboratory of Atmospheric Environment and Pollution
Control [h2xjD612004III]; State Environmental Protection Key Laboratory
of Sources and Control of Air Pollution Complex [SCAPC201308]; project
of Atmospheric Haze Collaboration Control Technology Design from Chinese
Academy of Sciences [XDB05030400]
FX Financial and data support for this work is provided by the U.S.
Environmental Protection Agency (No. GS-10F-0205T). This work is also
partly supported by the funding of Guangdong Provincial Key Laboratory
of Atmospheric Environment and Pollution Control (No. h2xjD612004III),
the funding of State Environmental Protection Key Laboratory of Sources
and Control of Air Pollution Complex (No. SCAPC201308), and the project
of Atmospheric Haze Collaboration Control Technology Design (No.
XDB05030400) from Chinese Academy of Sciences.
NR 21
TC 3
Z9 4
U1 3
U2 11
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1001-0742
EI 1878-7320
J9 J ENVIRON SCI-CHINA
JI J. Environ. Sci.
PD JAN 1
PY 2015
VL 27
BP 97
EP 107
DI 10.1016/j.jes.2014.08.016
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CA3SC
UT WOS:000348825400012
PM 25597667
ER
PT J
AU Tatum-Gibbs, KR
Mckee, JM
Higuchi, M
Bushnell, PJ
AF Tatum-Gibbs, K. R.
Mckee, J. M.
Higuchi, M.
Bushnell, P. J.
TI Effects of toluene, acrolein and vinyl chloride on motor activity of
Drosophila melanogaster
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Toxicity screening; Volatile organic compounds; Fruit fly; Sex
difference; Narcosis
ID VOLATILE ORGANIC-COMPOUNDS; GENOME-WIDE ASSOCIATION; GENETIC REFERENCE
PANEL; ODOR-GUIDED BEHAVIOR; LOCOMOTOR-ACTIVITY; NATURAL VARIATION;
OLFACTORY BEHAVIOR; ARCHITECTURE; COMMUNICATION; INHALATION
AB The data generated by current high-throughput assays for chemical toxicity require information to link effects at molecular targets to adverse outcomes in whole animals. In addition, more efficient methods for testing volatile chemicals are needed. Here we begin to address these issues by determining the utility of measuring behavioral responses of Drosophila melanogaster to airborne volatile organic compounds (VOCs) as a potential model system for discovering adverse outcome pathways and as a method to test for toxicity. In these experiments, we measured motor activity in male and female flies to determine concentration-effect functions for three VOCs that differ in their mode of action: toluene, a narcotic; acrolein, an irritant; and vinyl chloride, a hepatocarcinogen. These experiments were conducted in Flyland, an outbred population of flies derived from 40 lines of the Drosophila Genetics Reference Panel (DGRP) (Mackay et al., 2012), in preparation for subsequent experiments with individual lines of the DGRP. Systematic, concentration-related changes in activity were observed with toluene, but not with acrolein; high concentrations of vinyl chloride reduced activity by a small amount. Despite higher activity levels in males than in females under control conditions, the sexes were equally sensitive to toluene. Transient increases in activity at the onset and offset of exposure to toluene and vinyl chloride suggested that the flies detected changes in air quality at concentrations that did not persistently suppress activity. The effects and potency of toluene are consistent with those observed in rodents. The lack of clear concentration-related changes in response to acrolein and vinyl chloride shows limitations of this method is for screening toxicity attributed to VOCs. This abstract does not reflect U.S. EPA policy. Published by Elsevier Inc.
C1 [Tatum-Gibbs, K. R.] Oak Ridge Inst Sci Educ, Oak Ridge, TN USA.
[Mckee, J. M.; Higuchi, M.; Bushnell, P. J.] US EPA, Natl Hlth & Environm Effects Res Lab, RTP, Res Triangle Pk, NC 27711 USA.
RP Bushnell, PJ (reprint author), US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM Bushnell.philip@epa.gov
NR 49
TC 1
Z9 2
U1 1
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JAN-FEB
PY 2015
VL 47
BP 114
EP 124
DI 10.1016/j.ntt.2014.11.008
PG 11
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA CA5NL
UT WOS:000348955000013
PM 25445728
ER
PT J
AU Morgan, M
Jones, P
Sobus, J
AF Morgan, Marsha
Jones, Paul
Sobus, Jon
TI Short-Term Variability and Predictors of Urinary Pentachlorophenol
Levels in Ohio Preschool Children
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE biomarkers; urine; children; determinants; phenol; home; daycare center
ID PERSISTENT ORGANIC POLLUTANTS; INDOOR AIR; DAY-CARE; AGGREGATE
EXPOSURES; PESTICIDES; DUST; ENVIRONMENT; POPULATION; RESIDUES; DIAZINON
AB Pentachlorophenol (PCP) is a persistent and ubiquitous environmental contaminant. No published data exist on the temporal variability or important predictors of urinary PCP concentrations in young children. In this further analysis of study data, we have examined the associations between selected sociodemographic or lifestyle factors and urinary PCP concentrations in 115 preschool children over a 48-h period and assessed the 48-hour variability of urinary PCP levels in a subset of 15 children. Monitoring was performed at 115 homes and 16 daycares in Ohio (USA) in 2001. Questionnaires/diaries and spot urine samples were collected from each child. The median urinary PCP level was 0.8 ng/mL (range < 0.2-23.8 ng/mL). The intraclass correlation coefficient for urinary PCP was 0.42, which indicates fairly low reliability for a single sample over a 48-h period. In a multiple regression model, age of home and ln(creatinine levels) were significant predictors and sampling season, time spent outside, and pet ownership were marginally significant predictors of ln(urinary PCP levels), collectively explaining 29% of the variability of PCP in urine. To adequately assess short-term exposures of children to PCP, several spot urine measurements are likely needed as well as information regarding residence age, seasonality, time spent outdoors, and pet ownership.
C1 [Morgan, Marsha; Jones, Paul; Sobus, Jon] US EPA, Res Triangle Pk, NC 27711 USA.
RP Morgan, M (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM morgan.marsha@epa.gov; jones.paul-a@epa.gov; sobus.jon@epa.gov
FU United States Environmental Protection Agency through Office of Research
and Development [68-D-99-011]
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here
under Contract #68-D-99-011 to Battelle. It has been subjected to Agency
review and approved for publication.
NR 36
TC 1
Z9 1
U1 1
U2 10
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2015
VL 12
IS 1
BP 800
EP 815
DI 10.3390/ijerph120100800
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AZ7MP
UT WOS:000348403300047
PM 25594782
ER
PT J
AU Sickles, JE
Shadwick, DS
AF Sickles, J. E., II
Shadwick, D. S.
TI Air quality and atmospheric deposition in the eastern US: 20 years of
change
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID DRY DEPOSITION; UNITED-STATES; TRENDS-NETWORK; PARTICULATE SULFATE;
NITROGEN DEPOSITION; MULTILAYER MODEL; AEROSOL NITRATE; SULFUR;
EMISSIONS; FORESTS
AB Data collected in the eastern US between 1990 and 2009 at 34 paired dry and wet monitoring sites are examined. A goal is to evaluate the air quality impacts occurring between 1990 and 2009 that are associated with concurrent legislatively mandated changes in emissions. Four 5-year periods, 1990-1994 (P1), 1995-1999 (P2), 2000-2004 (P3), and 2005-2009 (P4) are considered, with a primary focus on P1-to-P4 changes. Results suggest that legislatively mandated air pollution mitigation strategies have been successful in improving air quality and reducing atmospheric deposition in the eastern US.
Respective P1-to-P4 reductions of estimated sulfur dioxide (SO2) and nitrogen oxides (NOx) emissions in the eastern US are 50 and 42 %. Corresponding behavior of the following metrics associated with these emissions reductions is examined: monitored atmospheric concentrations of SO2, aerosol sulfate (SO4), and oxidized sulfur (S); dry, wet, and total deposition of S; monitored atmospheric concentrations of nitric acid (HNO3), aerosol nitrate (NO3), and their sum, oxidized nitrogen (OxN); dry, wet, and total deposition of OxN; monitored atmospheric concentration of aerosol ammonium (NH4); dry, wet, and total deposition of NH4; summed monitored atmospheric concentration of oxidized and reduced nitrogen (N); dry, wet, and total deposition of N; wet deposition of hydrogen ion (H+); monitored atmospheric concentration of ozone (O-3); dry deposition of O-3; and the summed monitored atmospheric concentration of aerosol NO3, SO4, and NH4 (Clean Air Status and Trends Network particulate matter - CASTNET PM). Other metrics (e.g., ratios of dry to total deposition) are also considered.
Selected period-to-period changes of air quality and deposition metrics at site, regional, and seasonal scales are discussed. As an example, despite P1-to-P3 reductions in estimated emissions of both SO2 and NOx, aerosol NO3 concentration increased in the east, with widespread wintertime numerical increases in both aerosol NO3 concentration and CASTNET PM. However, a reversal of this behavior is associated with continuing P3-to-P4 reductions of SO2 and NOx emissions. Thus, additional P3-to-P4 reductions of these emissions, especially NOx, appear to have made progress in altering the chemical regime of the wintertime eastern US atmosphere so that future emissions reductions and their resulting reductions in aerosol concentrations may no longer be accompanied by sub-linear changes (or actual increases) in CASTNET PM.
C1 [Sickles, J. E., II] US EPA, Landscape Characterizat Branch, Div Environm Sci, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Shadwick, D. S.] Comp Sci Corp, Durham, NC 27713 USA.
RP Sickles, JE (reprint author), US EPA, Landscape Characterizat Branch, Div Environm Sci, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM sickles.joseph@epa.gov
FU US EPA through its Office of Research and Development [GS-35F-4381G,
BPA0775, 1521, TDD 2-5]
FX The US EPA, through its Office of Research and Development, funded and
partially performed the research described here under contract
GS-35F-4381G, BPA0775, Task Order 1521, TDD 2-5, to CSC Corporation.
This manuscript has been subjected to Agency review and approved for
publication.
NR 41
TC 7
Z9 9
U1 5
U2 61
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 1
BP 173
EP 197
DI 10.5194/acp-15-173-2015
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AZ0TQ
UT WOS:000347958200011
ER
PT J
AU Bal-Price, A
Crofton, KM
Sachana, M
Shafer, TJ
Behl, M
Forsby, A
Hargreaves, A
Landesmann, B
Lein, PJ
Louisse, J
Monnet-Tschudi, F
Paini, A
Rolaki, A
Schrattenholz, A
Sunol, C
van Thriel, C
Whelan, M
Fritsche, E
AF Bal-Price, Anna
Crofton, Kevin M.
Sachana, Magdalini
Shafer, Timothy J.
Behl, Mamta
Forsby, Anna
Hargreaves, Alan
Landesmann, Brigitte
Lein, Pamela J.
Louisse, Jochem
Monnet-Tschudi, Florianne
Paini, Alicia
Rolaki, Alexandra
Schrattenholz, Andre
Sunol, Cristina
van Thriel, Christoph
Whelan, Maurice
Fritsche, Ellen
TI Putative adverse outcome pathways relevant to neurotoxicity
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Review
DE adverse outcome pathway; in vitro testing; key events; molecular
initiating event; pathways of neurotoxicity; predictive toxicology
ID POSTOPERATIVE COGNITIVE DYSFUNCTION; ESTROGEN-RECEPTOR BINDING;
DEVELOPMENTAL NEUROTOXICITY; RISK-ASSESSMENT; NERVOUS-SYSTEM;
ALTERNATIVE METHODS; MAGNETIC-RESONANCE; MATURE HIPPOCAMPUS; PROGENITOR
CELLS; ANIMAL-MODELS
AB The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological target(s), followed by a sequential series of KEs, which are cellular, anatomical, and/or functional changes in biological processes, that ultimately result in an AO manifest in individual organisms and populations. It has been developed as a tool for a knowledge-based safety assessment that relies on understanding mechanisms of toxicity, rather than simply observing its adverse outcome. A large number of cellular and molecular processes are known to be crucial to proper development and function of the central (CNS) and peripheral nervous systems (PNS). However, there are relatively few examples of well-documented pathways that include causally linked MIEs and KEs that result in adverse outcomes in the CNS or PNS. As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) organized a workshop (March 2013, Ispra, Italy) to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes. Although the AOPs outlined during the workshop are not fully described, they could serve as a basis for further, more detailed AOP development and evaluation that could be useful to support human health risk assessment in a variety of ways.
C1 [Bal-Price, Anna; Sachana, Magdalini; Landesmann, Brigitte; Louisse, Jochem; Paini, Alicia; Rolaki, Alexandra; Whelan, Maurice] European Commiss Joint Res Ctr, Inst Hlth & Consumer Protect, Ispra, Italy.
[Crofton, Kevin M.; Shafer, Timothy J.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA.
[Behl, Mamta] Natl Inst Environm Hlth Sci, Div Natl Toxicol Program, Res Triangle Pk, NC USA.
[Forsby, Anna] Stockholm Univ, Arrhenius Labs NaturalSci, Dept Neurochem, S-10691 Stockholm, Sweden.
[Forsby, Anna] Swedish Toxicol Sci Res Ctr, Swetox, Sodertalje, Sweden.
[Hargreaves, Alan] Nottingham Trent Univ, Nottingham, England.
[Lein, Pamela J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
[Monnet-Tschudi, Florianne] Univ Lausanne, Dept Physiol, Lausanne, Switzerland.
[Monnet-Tschudi, Florianne] Univ Lausanne, SCAHT, Lausanne, Switzerland.
[Schrattenholz, Andre] ProteoSys AG, Mainz, Germany.
[Sunol, Cristina] CIBERESP, IDIBAPS, IIBB CSIC, Inst Invest Biomed Barcelona, Barcelona, Spain.
[van Thriel, Christoph] IfADo Leibniz Res Ctr Working Environm & Human Fa, Dortmund, Germany.
[Fritsche, Ellen] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.
RP Bal-Price, A (reprint author), Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, Syst Toxicol Unit,EURL ECVAM, TP 580,Via Fermi 1, I-21026 Ispra, VA, Italy.
EM anna.price@jrc.ec.europa
RI Crofton, Kevin/J-4798-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Forsby, Anna/0000-0001-6298-201X;
Cristina, Sunol/0000-0001-9367-8483; Hargreaves,
Alan/0000-0001-9754-5477
FU European Commission
FX The employment affiliation of the authors is shown on the cover page.
The authors have sole responsibility for the writing and content of this
paper. The contributing authors were participants of the workshop
organized by the EURL ECVAM. The external workshop participants were
invited on the basis of a survey performed by EURL ECVAM neurotoxicity
experts of the latest literature to identify those with specific
expertise in the relevant research fields. The workshop organization was
financially supported by the European Commission, including the cost of
travelling and per diem of all invited external experts. The strategy
for preparing the report, the literature selected for review, the
conclusions drawn and the recommendations made are exclusively the
collective scientific output of the workshop participants and do not
necessarily represent the views of the participants' employers.
NR 66
TC 13
Z9 13
U1 5
U2 34
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1040-8444
EI 1547-6898
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD JAN
PY 2015
VL 45
IS 1
BP 83
EP 91
DI 10.3109/10408444.2014.981331
PG 9
WC Toxicology
SC Toxicology
GA AZ4NN
UT WOS:000348199100005
PM 25605028
ER
PT J
AU Nixon, SW
Oczkowski, AJ
Pilson, MEQ
Fields, L
Oviatt, CA
Hunt, CW
AF Nixon, Scott W.
Oczkowski, Autumn J.
Pilson, Michael E. Q.
Fields, Lindsey
Oviatt, Candace A.
Hunt, Christopher W.
TI On the Response of pH to Inorganic Nutrient Enrichment in Well-Mixed
Coastal Marine Waters
SO ESTUARIES AND COASTS
LA English
DT Article
DE Coastal acidification; pH; Nutrient enrichment; Eutrophication;
Mesocosms; Narragansett Bay
ID ORGANIC-CARBON BALANCE; OCEAN ACIDIFICATION; NARRAGANSETT BAY; ECOSYSTEM
METABOLISM; EUTROPHICATION; PHYTOPLANKTON; CO2; SALINITY; GROWTH;
ESTUARINE
AB Recent concerns about declining pH in the surface ocean in response to anthropogenic increases of carbon dioxide (CO2) in the atmosphere have raised the question of how this declining baseline of oceanic pH might interact with the much larger diel and seasonal variations of pH in coastal marine ecosystems. Nutrient enrichment, which can amplify both production and respiration, has the potential to reduce or exacerbate the impacts of ocean acidification in coastal waters. Here, we present results from a multi-year experiment in which replicate phytoplankton-based mesocosms with a 5-m deep well-mixed water column (salinity = 27-31) and intact benthic community were exposed to a gradient in daily inorganic nitrogen (N), phosphorous (P), and silica (Si) addition. We show that the response of water column pH to nutrient enrichment was the greatest during the autotrophic winter-spring period, and there was no significant decline in pH across treatments during the heterotrophic summer-fall period. We believe that the differences in response lie in the seasonal cycles of production and respiration, where spring production peaks are large and discrete, and respiration is more temperature-driven but occurs diffusely throughout the year. The observed basification associated with enhanced nutrient inputs may have consequences for phytoplankton community structure, some species of submersed aquatic vegetation, cycling of Si, and perhaps other ecological processes.
C1 [Nixon, Scott W.; Pilson, Michael E. Q.; Fields, Lindsey; Oviatt, Candace A.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
[Oczkowski, Autumn J.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Hunt, Christopher W.] Univ New Hampshire, Ocean Proc Anal Lab, Durham, NH 03824 USA.
RP Oczkowski, AJ (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM oczkowski.autumn@epa.gov
OI Hunt, Christopher/0000-0001-8061-4560
FU Environmental Protection Agency Centers Program [807795-02, 810265-01];
NSF [12010, OCE851447]; US Environmental Protection Agency
FX The observations described in this manuscript were discovered by S.
Nixon. He began writing the text of the manuscript and, after his
untimely death, his coauthors completed the manuscript and published it
posthumously in his honor. We would like to thank the scientists and
technicians who worked on the MERL mesocosm experiments, and upon whose
careful measurements, this manuscript is based. We are grateful to Alana
Hanson for some statistical support. The MERL nutrient addition
experiment was supported by the Environmental Protection Agency Centers
Program, Cooperative Agreements 807795-02 and 810265-01. Support for
this work was also partially provided by the NSF Awards 12010 and
OCE851447. This is ORD tracking number ORD-003895 of the Atlantic
Ecology Division, National Health and Environmental Effects Research
Laboratory, Office of Research and Development, US Environmental
Protection Agency. Although the research described in this article has
been funded in part by the US Environmental Protection Agency, it has
not been subjected to Agency review. Therefore, it does not necessarily
reflect the views of the Agency.
NR 63
TC 3
Z9 3
U1 3
U2 40
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
IS 1
BP 232
EP 241
DI 10.1007/s12237-014-9805-6
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AY6MM
UT WOS:000347680300019
ER
PT J
AU Russell, M
Greening, H
AF Russell, Marc
Greening, Holly
TI Estimating Benefits in a Recovering Estuary: Tampa Bay, Florida
SO ESTUARIES AND COASTS
LA English
DT Article
DE Ecosystem goods; Tampa Bay; Estuarine valuation; Habitat restoration;
Water quality
ID MANGROVE SEDIMENTS; INORGANIC NITROGEN; ECOSYSTEM SERVICES;
WATER-QUALITY; DENITRIFICATION; SEAGRASS; EUTROPHICATION; FLUXES;
CARBON; REDUCTIONS
AB Restoration and preservation of riparian forests and coastal marshes provides nutrient removal and other biochemical and physical functions which may preclude, reduce, or delay the need for additional water treatment, while also protecting human health. We examined the ecosystem goods and related potential cost savings for the Tampa Bay community from seagrass expansion (more than 3,100 ha since 1990), coastal marsh, and mangrove restoration/recovery (more than 600 ha since 1990), and habitat that has been maintained or preserved. Habitats in and around Tampa Bay provide nutrient reductions equivalent to just over US$22 million per year in avoided wastewater treatment plant costs. Future accrual of value associated with maintaining the ecosystem good of usable clean water could rapidly increase to as high as similar to US$ 3 billion per year, when one takes into account the additional costs of water treatment and storm water diversion infrastructure that is likely as the region's population continues to grow. There is additional value accrual close to a quarter million dollars per year based on avoided social costs to the global community due to greenhouse gases sequestered by bay habitats. Most human beneficiaries associated with the maintenance of usable clean water in Tampa Bay are part of the surrounding regional community. The large current and future cost savings for the community surrounding Tampa Bay and additional benefits for the global community speak to the value of maintaining a healthy bay through past and continued restoration and preservation efforts.
C1 [Russell, Marc] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32563 USA.
[Greening, Holly] Tampa Bay Estuary Program, Petersburg, FL 33701 USA.
RP Russell, M (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32563 USA.
EM Russell.Marc@epamail.epa.gov
NR 52
TC 1
Z9 1
U1 9
U2 69
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S9
EP S18
DI 10.1007/s12237-013-9662-8
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700002
ER
PT J
AU Teisl, MF
McCoy, S
Marrinan, S
Noblet, CL
Johnson, T
Wibberly, M
Roper, R
Klein, S
AF Teisl, Mario F.
McCoy, Shannon
Marrinan, Sarah
Noblet, Caroline L.
Johnson, Teresa
Wibberly, Megan
Roper, Robert
Klein, Sharon
TI Will Offshore Energy Face "Fair Winds and Following Seas"?:
Understanding the Factors Influencing Offshore Wind Acceptance
SO ESTUARIES AND COASTS
LA English
DT Article
DE Offshore wind power; Public acceptance
ID PUBLIC ACCEPTANCE; POWER PROJECTS; ATTITUDES; TURBINES; FARMS
AB Most offshore energy studies have focused on measuring or explaining people's perceptions of, and reactions to, specific installations. However, there are two different types of acceptance: one surrounds the siting of projects while the other surrounds a more general acceptance of offshore energy. Understanding what drives this second type of acceptance is important as governments have implemented new financial incentives and policies to support renewable energy development; however, citizens and government officials may be increasingly opposed to some of these support mechanisms. Our paper fills a void in the literature by using regression approaches to better understand how people's evaluations of the benefits and costs of offshore wind impact their level of general acceptance for offshore wind, while controlling for other factors (e.g., demographics). This analysis should help policy makers, and individuals attempting to educate the general public about renewable energy, to better understand the important factors influencing people's support or opposition to offshore wind energy initiatives.
C1 [Teisl, Mario F.; Noblet, Caroline L.; Klein, Sharon] Univ Maine, Sch Econ, Orono, ME 04469 USA.
[McCoy, Shannon] Univ Maine, Dept Psychol, Orono, ME 04469 USA.
[Marrinan, Sarah] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
[Johnson, Teresa] Univ Maine, Sch Marine Sci, Orono, ME 04469 USA.
[Wibberly, Megan] Isl Inst, Rockland, ME 04841 USA.
[Roper, Robert] Univ Maine Augusta, Business Adm, Augusta, ME 04330 USA.
RP Teisl, MF (reprint author), Univ Maine, Sch Econ, Orono, ME 04469 USA.
EM teisl@maine.edu
OI teisl, mario/0000-0002-2021-9208
FU Maine Sustainability Solutions Initiative; National Science Foundation
[EPS-0904155]; Maine Agriculture and Forest Experiment Station
FX Funding was provided by the Maine Sustainability Solutions Initiative,
the National Science Foundation Grant EPS-0904155 to Maine EPSCoR at the
University of Maine, and the Maine Agriculture and Forest Experiment
Station.
NR 41
TC 2
Z9 2
U1 2
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S279
EP S286
DI 10.1007/s12237-014-9777-6
PG 8
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700023
ER
PT J
AU Yoskowitz, D
Russell, M
AF Yoskowitz, David
Russell, Marc
TI Human Dimensions of Our Estuaries and Coasts
SO ESTUARIES AND COASTS
LA English
DT Editorial Material
ID ECOLOGICAL RESILIENCE
C1 [Yoskowitz, David] Texas A&M Univ Corpus Christi, Harte Res Inst, Corpus Christi, TX 78412 USA.
[Russell, Marc] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Yoskowitz, D (reprint author), Texas A&M Univ Corpus Christi, Harte Res Inst, 6300 Ocean Dr, Corpus Christi, TX 78412 USA.
EM david.yoskowitz@tamucc.edu
NR 20
TC 3
Z9 3
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S1
EP S8
DI 10.1007/s12237-014-9926-y
PG 8
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700001
ER
PT J
AU Briskin, J
AF Briskin, Jeanne
TI Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking
Water Resources
SO GROUNDWATER
LA English
DT Editorial Material
C1 US EPA, Off Water, Engn & Anal Div, Washington, DC 20460 USA.
RP Briskin, J (reprint author), US EPA, Off Water, Engn & Anal Div, 1200 Penn Ave,NW, Washington, DC 20460 USA.
EM Briskin.Jeanne@epa.gov
NR 0
TC 1
Z9 1
U1 1
U2 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0017-467X
EI 1745-6584
J9 GROUNDWATER
JI Groundwater
PD JAN-FEB
PY 2015
VL 53
IS 1
BP 19
EP 21
PG 3
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA AZ1EA
UT WOS:000347981800006
PM 25713827
ER
PT J
AU Brown, JS
AF Brown, James S.
TI Nitrogen dioxide exposure and airway responsiveness in individuals with
asthma
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Air pollution; airway responsiveness; asthma; nitrogen dioxide
ID EMERGENCY-DEPARTMENT VISITS; SHORT-TERM EXPOSURE; INHALED ALLERGEN;
BRONCHIAL RESPONSIVENESS; AMBIENT LEVEL; PROVOKED BRONCHOCONSTRICTION;
PULMONARY-FUNCTION; DEEP INSPIRATION; CASE-CROSSOVER; METHACHOLINE
AB Controlled human exposure studies evaluating the effect of inhaled nitrogen dioxide (NO2) on the inherent responsiveness of the airways to challenge by broncho-constricting agents have had mixed results. In general, existing meta-analyses show statistically significant effects of NO2 on the airway responsiveness of individuals with asthma. However, no meta-analysis has provided a comprehensive assessment of the clinical relevance of changes in airway responsiveness, the potential for methodological biases in the original papers, and the distribution of responses. This paper provides analyses showing that a statistically significant fraction (i.e. 70% of individuals with asthma exposed to NO2 at rest) experience increases in airway responsiveness following 30-min exposures to NO2 in the range of 200 to 300 ppb and following 60-min exposures to 100 ppb. The distribution of changes in airway responsiveness is log-normally distributed with a median change of 0.75 (provocative dose following NO2 divided by provocative dose following filtered air exposure) and geometric standard deviation of 1.88. About a quarter of the exposed individuals experience a clinically relevant reduction in their provocative dose due to NO2 relative to air exposure. The fraction experiencing an increase in responsiveness was statistically significant and robust to exclusion of individual studies. Results showed minimal change in airway responsiveness for individuals exposed to NO2 during exercise.
C1 US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Brown, JS (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, B243-01, Res Triangle Pk, NC 27711 USA.
EM Brown.James@epa.gov
NR 66
TC 2
Z9 2
U1 3
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN
PY 2015
VL 27
IS 1
BP 1
EP 14
DI 10.3109/08958378.2014.979960
PG 14
WC Toxicology
SC Toxicology
GA AZ3QN
UT WOS:000348141900001
PM 25431034
ER
PT J
AU Perez, CM
Hazari, MS
Ledbetter, AD
Haykal-Coates, N
Carll, AP
Cascio, WE
Winsett, DW
Costa, DL
Farraj, AK
AF Perez, Christina M.
Hazari, Mehdi S.
Ledbetter, Allen D.
Haykal-Coates, Najwa
Carll, Alex P.
Cascio, Wayne E.
Winsett, Darrell W.
Costa, Daniel L.
Farraj, Aimen K.
TI Acrolein inhalation alters arterial blood gases and triggers carotid
body-mediated cardiovascular responses in hypertensive rats
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Acrolein; blood pressure; carotid body; pO(2); spontaneously
hypertensive rat
ID OBSTRUCTIVE PULMONARY-DISEASE; HEART-RATE-VARIABILITY;
INFANT-DEATH-SYNDROME; AIR-POLLUTION; OXYGEN-SATURATION; EXPOSURE;
SMOKE; HYPOXIA; STRESS; BODIES
AB Context: Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen and carbon dioxide levels, and elicits downstream changes in autonomic control and cardiac function.
Objective: We hypothesized that exposure to acrolein, an unsaturated aldehyde and mucosal irritant found in cigarette smoke and diesel exhaust, would activate the carotid body chemoreceptor response and lead to secondary cardiovascular responses in rats.
Materials and methods: Spontaneously hypertensive (SH) rats were exposed once for 3 h to 3 ppm acrolein gas or filtered air in whole body plethysmograph chambers. To determine if the carotid body mediated acrolein-induced cardiovascular responses, rats were pretreated with an inhibitor of cystathionine gamma-lyase (CSE), an enzyme essential for carotid body signal transduction.
Results: Acrolein exposure induced several cardiovascular effects. Systolic, diastolic and mean arterial blood pressure increased during exposure, while cardiac contractility decreased 1 day after exposure. The cardiovascular effects were associated with decreases in pO(2), breathing frequency and expiratory time, and increases in sympathetic tone during exposure followed by parasympathetic dominance after exposure. The CSE inhibitor prevented the cardiovascular effects of acrolein exposure.
Discussion and conclusion: Pretreatment with the CSE inhibitor prevented the cardiovascular effects of acrolein, suggesting that the cardiovascular responses with acrolein may be mediated by carotid body-triggered changes in autonomic tone. (This abstract does not reflect EPA policy.)
C1 [Perez, Christina M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Hazari, Mehdi S.; Ledbetter, Allen D.; Cascio, Wayne E.; Winsett, Darrell W.; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Haykal-Coates, Najwa] US EPA, Biostatt & Bioinformat Res Core Unit, NHEERL, Res Triangle Pk, NC 27711 USA.
[Carll, Alex P.] Univ N Carolina, Chapel Hill, NC USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Perez, CM (reprint author), US EPA, Environm Publ Hlth Div, B143-01, Res Triangle Pk, NC 27711 USA.
EM clamb@email.unc.edu
OI Carll, Alex/0000-0003-1832-3070
FU EPA/UNC Toxicology Training Agreement [CR-83515201-0]
FX This work was supported by the EPA/UNC Toxicology Training Agreement
[CR-83515201-0 to C.M.P. and A.P.C.]. The funding sources had no
involvement in this work, and all authors report no declaration of
interest.
NR 37
TC 3
Z9 3
U1 0
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN
PY 2015
VL 27
IS 1
BP 54
EP 63
DI 10.3109/08958378.2014.984881
PG 10
WC Toxicology
SC Toxicology
GA AZ3QN
UT WOS:000348141900004
PM 25600140
ER
PT J
AU Ge, Y
Bruno, M
Wallace, K
Leavitt, S
Andrews, D
Spassova, MA
Xi, MY
Roy, A
Haykal-Coates, N
Lefew, W
Swank, A
Winnik, WM
Chen, C
Woodard, J
Farraj, A
Teichman, KY
Ross, JA
AF Ge, Yue
Bruno, Maribel
Wallace, Kathleen
Leavitt, Sharon
Andrews, Debora
Spassova, Maria A.
Xi, Mingyu
Roy, Anindya
Haykal-Coates, Najwa
Lefew, William
Swank, Adam
Winnik, Witold M.
Chen, Chao
Woodard, Jonne
Farraj, Aimen
Teichman, Kevin Y.
Ross, Jeffrey A.
TI Systematic Proteomic Approach to Characterize the Impacts of Chemical
Interactions on Protein and Cytotoxicity Responses to Metal Mixture
Exposures
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE chemical interactions; dose response; mixture toxicity; chemical
mixtures; risk assessment; proteomics; cytotoxicity; metals; systems
biology
ID TOXICITY; CELLS; NICKEL
AB Chemical interactions have posed a big challenge in toxicity characterization and human health risk assessment of environmental mixtures. To characterize the impacts of chemical interactions on protein and cytotoxicity responses to environmental mixtures, we established a systems biology approach integrating proteomics, bioinformatics, statistics, and computational toxicology to measure expression or phosphorylation levels of 21 critical toxicity pathway regulators and 445 downstream proteins in human BEAS-2B cells treated with 4 concentrations of nickel, 2 concentrations each of cadmium and chromium, as well as 12 defined binary and 8 defined ternary mixtures of these metals in vitro. Multivariate statistical analysis and mathematical modeling of the metal-mediated proteomic response patterns showed a high correlation between changes in protein expression or phosphorylation and cellular toxic responses to both individual metals and metal mixtures. Of the identified correlated proteins, only a small set of proteins including HIF-1 alpha is likely to be responsible for selective cytotoxic responses to different metals and metals mixtures. Furthermore, support vector machine learning was utilized to computationally predict protein responses to uncharacterized metal mixtures using experimentally generated protein response profiles corresponding to known metal mixtures. This study provides a novel proteomic approach for characterization and prediction of toxicities of metal and other chemical mixtures.
C1 [Ge, Yue; Bruno, Maribel; Wallace, Kathleen; Leavitt, Sharon; Andrews, Debora; Haykal-Coates, Najwa; Lefew, William; Swank, Adam; Winnik, Witold M.; Woodard, Jonne; Farraj, Aimen; Ross, Jeffrey A.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
[Spassova, Maria A.; Chen, Chao] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Teichman, Kevin Y.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Xi, Mingyu; Roy, Anindya] Univ Maryland, Dept Stat, College Pk, MD 20742 USA.
RP Ge, Y (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM ge.yue@epa.gov
OI Ross, Jeffrey/0000-0002-7002-4548
FU Pathfinder Innovation Project (PIP) from Office of Research and
Development ORD), U.S. Environmental Protection Agency
FX This research was supported by the Pathfinder Innovation Project (PIP)
from Office of Research and Development ORD), U.S. Environmental
Protection Agency. We acknowledge all of the support provided by Peter
Preuss and the innovation team, ORD. We also thank Drs. Andrew
Kligerman, Julian Preston, and Mehdi Hazari for their very helpful
comments on this manuscript and Alan Tennant for his assistance on the
apoptosis imaging. The information in this document has been funded
wholly by the U.S. Environmental Protection Agency. It has been
subjected to review by the National Health and Environmental Effects
Research Laboratory and approved for publication. Approval does not
signify that the contents reflect the views of the Agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 20
TC 4
Z9 4
U1 0
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JAN
PY 2015
VL 14
IS 1
BP 183
EP 192
PG 10
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA AY3UA
UT WOS:000347506600016
PM 25285964
ER
PT J
AU Kapoor, V
Pitkanen, T
Ryu, H
Elk, M
Wendell, D
Domingo, JWS
AF Kapoor, Vikram
Pitkaenen, Tarja
Ryu, Hodon
Elk, Michael
Wendell, David
Domingo, Jorge W. Santo
TI Distribution of Human-Specific Bacteroidales and Fecal Indicator
Bacteria in an Urban Watershed Impacted by Sewage Pollution, Determined
Using RNA-and DNA-Based Quantitative PCR Assays
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID 16S RIBOSOMAL-RNA; MICROBIAL SOURCE TRACKING; ESCHERICHIA-COLI;
CONTAMINATION; IDENTIFICATION; POPULATIONS; COMMUNITY; QPCR;
ENVIRONMENTS; ENTEROCOCCUS
AB The identification of fecal pollution sources is commonly carried out using DNA-based methods. However, there is evidence that DNA can be associated with dead cells or present as "naked DNA" in the environment. Furthermore, it has been shown that rRNA-targeted reverse transcription-quantitative PCR (RT-qPCR) assays can be more sensitive than rRNA gene-based qPCR assays since metabolically active cells usually contain higher numbers of ribosomes than quiescent cells. To this end, we compared the detection frequency of host-specific markers and fecal bacteria using RNA-based RT-qPCR and DNA-based qPCR methods for water samples collected in sites impacted by combined sewer overflows. As a group, fecal bacteria were more frequently detected in most sites using RNA-based methods. Specifically, 8, 87, and 85% of the samples positive for general enterococci, Enterococcus faecalis, and Enterococcus faecium markers, respectively, were detected using RT-qPCR, but not with the qPCR assay counterpart. On average, two human-specific Bacteroidales markers were not detected when using DNA in 12% of the samples, while they were positive for all samples when using RNA (cDNA) as the template. Moreover, signal intensity was up to three orders of magnitude higher in RT-qPCR assays than in qPCR assays. The human-specific Bacteroidales markers exhibited moderate correlation with conventional fecal indicators using RT-qPCR results, suggesting the persistence of nonhuman sources of fecal pollution or the presence of false-positive signals. In general, the results from this study suggest that RNA-based assays can increase the detection sensitivity of fecal bacteria in urban watersheds impacted with human fecal sources.
C1 [Kapoor, Vikram; Ryu, Hodon; Elk, Michael] Pegasus Tech Serv Inc, Cincinnati, OH USA.
[Kapoor, Vikram; Wendell, David] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH USA.
[Pitkaenen, Tarja] Natl Inst Hlth & Welf, Water & Hlth Unit, Kuopio, Finland.
[Pitkaenen, Tarja; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Domingo, JWS (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM wendeldw@uc.edu; santodomingo.jorge@epa.gov
RI Pitkanen, Tarja/D-1657-2014
OI Pitkanen, Tarja/0000-0002-7591-9148
FU University Research Council fellowship at University of Cincinnati; Osk.
Huttunen Foundation; National Research Council; Metropolitan Sewer
District of Greater Cincinnati (Cincinnati, OH); U.S. Environmental
Protection Agency, through its Office of Research and Development;
Finnish Cultural Foundation; University of Eastern Finland
FX V.K. was funded by a University Research Council fellowship at
University of Cincinnati. T.P. was supported by research grants from the
Osk. Huttunen Foundation, the Finnish Cultural Foundation, and the
University of Eastern Finland. H.R. was the recipient of a National
Research Council fellowship. This research was in part funded by
Metropolitan Sewer District of Greater Cincinnati (Cincinnati, OH). The
U.S. Environmental Protection Agency, through its Office of Research and
Development, provided funds and collaborated in the research described
here.
NR 57
TC 8
Z9 8
U1 2
U2 25
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JAN
PY 2015
VL 81
IS 1
BP 91
EP 99
DI 10.1128/AEM.02446-14
PG 9
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AY1TZ
UT WOS:000347376200011
PM 25326295
ER
PT J
AU Chu, DA
Ferrare, R
Szykman, J
Lewis, J
Scarino, A
Hains, J
Burton, S
Chen, G
Tsai, T
Hostetler, C
Hair, J
Holben, B
Crawford, J
AF Chu, D. Allen
Ferrare, Richard
Szykman, James
Lewis, Jasper
Scarino, Amy
Hains, Jennifer
Burton, Sharon
Chen, Gao
Tsai, Tzuchin
Hostetler, Chris
Hair, Johnathan
Holben, Brent
Crawford, James
TI Regional characteristics of the relationship between columnar AOD and
surface PM2.5: Application of lidar aerosol extinction profiles over
Baltimore-Washington Corridor during DISCOVER-AQ
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE DISCOVER-AQ; Baltimore-Washington Corridor; HSRL; MPLNET; DRAGON;
AERONET; MODIS; ADD; Aerosol mixing layer; Haze layer height; PM2.5
ID BOUNDARY-LAYER DEPTH; OPTICAL DEPTH; AIR-QUALITY; PARTICULATE; MODIS;
POLLUTION; URBAN; LAND; VALIDATION; THICKNESS
AB The first field campaign of DISCOVER-AQ (Deriving Information on Surface conditions from COlumn and VERtically resolved observations relevant to Air Quality) took place in July 2011 over Baltimore-Washington Corridor (BWC). A suite of airborne remote sensing and in-situ sensors was deployed along with ground networks for mapping vertical and horizontal distribution of aerosols. Previous researches were based on a single lidar station because of the lack of regional coverage. This study uses the unique airborne HSRL (High Spectral Resolution Lidar) data to baseline PM2.5 (particulate matter of aerodynamic diameter less than 2.5 mu m) estimates and applies to regional air quality with satellite AOD (Aerosol Optical Depth) retrievals over BWC (similar to 6500 km(2)). The linear approximation takes into account aerosols aloft above AML (Aerosol Mixing Layer) by normalizing AOD with haze layer height (i.e., AOD/HLH). The estimated PM2.5 mass concentrations by HSRL AOD/FILH are shown within 2 RMSE (Root Mean Square Error similar to 9.6 mu g/m(3)) with correlation similar to 0.88 with the observed over BWC. Similar statistics are shown when applying HLH data from a single location over the distance of 100 km. In other words, a single lidar is feasible to cover the range of 100 km with expected uncertainties. The employment of MPLNET-AERONET (MicroPulse Lidar NETwork - AErosol RObotic NETwork) measurements at NASA GSFC produces similar statistics of PM2.5 estimates as those derived by HSRL. The synergy of active and passive remote sensing aerosol measurements provides the foundation for satellite application of air quality on a daily basis. For the optimal range of 10 km, the MODIS-estimated PM2.5 values are found satisfactory at 27 (out of 36) sunphotometer locations with mean RMSE of 1.6-3.3 mu g/m(3) relative to PM2.5 estimated by sunphotometers. The remaining 6 of 8 marginal sites are found in the coastal zone, for which associated large RMSE values similar to 4.5-7.8 mu g/m(3) are most likely due to overestimated AOD because of water-contaminated pixels. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chu, D. Allen; Lewis, Jasper] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
[Chu, D. Allen; Lewis, Jasper; Holben, Brent] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Ferrare, Richard; Szykman, James; Scarino, Amy; Burton, Sharon; Chen, Gao; Hostetler, Chris; Hair, Johnathan; Crawford, James] NASA, Langley Res Ctr, Sci Directorate, Hampton, VA 23665 USA.
[Szykman, James] US EPA, Res Triangle Pk, NC 27711 USA.
[Hains, Jennifer] Maryland Dept Environm, Baltimore, MD 21224 USA.
[Tsai, Tzuchin] Univ Maryland, College Pk, MD 20742 USA.
[Tsai, Tzuchin] Natl Taiwan Univ, Taipei 10764, Taiwan.
RP Chu, DA (reprint author), NASA, Goddard Space Flight Ctr, JCET UMBC, Greenbelt, MD 20771 USA.
EM allen.chu@nasa.gov
RI Xiongfei, Zhao/G-7690-2015
FU NASA DISCOVER-AQ [NNX10AR41G]; NASA Air Now [NNX11A176G]
FX We would like to thank HSRL and LARGE teams for acquiring and processing
measurements during DISCOVER-AQ field campaign in July 2011 as well as
AERONET/DRAGON and MPLNET teams for processing sunphotometer and
micro-pulse lidar data. Thanks especially go to Maryland Department of
Environment for providing hourly PM2.5 and meteorological
measurements. We would also like to thank MODIS aerosol team and MODAP
for processing MODIS AOD retrievals. The development of the methodology
and the analysis of multiple-sensor data products are performed under
the NASA grants DISCOVER-AQ (NNX10AR41G) and Air Now (NNX11A176G). The
views, opinions, and findings contained in this article are those of the
authors and should not be construed as official U.S. Environmental
Protection Agency, National Aeronautics and Space Administration, or
U.S. Government position, policy, or decision
NR 39
TC 10
Z9 10
U1 6
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JAN
PY 2015
VL 101
BP 338
EP 349
DI 10.1016/j.atmosenv.2014.11.034
PG 12
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AZ1SB
UT WOS:000348017000034
ER
PT J
AU Zhao, HB
Peddada, SD
Cui, XP
AF Zhao, Haibing
Peddada, Shyamal D.
Cui, Xinping
TI Mixed directional false discovery rate control in multiple pairwise
comparisons using weighted p-values
SO BIOMETRICAL JOURNAL
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Multiple Comparison Procedures (MCP2013)
CY JUL 08-11, 2013
CL Univ Southampton, Southampton, UNITED KINGDOM
HO Univ Southampton
DE Benjamini Hochberg procedure; Microarray; Mixed directional false
discovery rate; Multiple pairwise comparison; Weighted p-value
ID LIVER-CANCER; ACETAMINOPHEN; PROPORTION; LANDSCAPE; TUMORS; NULL
AB In many applications, researchers are interested in making q pairwise comparisons among k test groups on the basis of m outcome variables. Often, m is very large. For example, such situations arise in gene expression microarray studies involving several experimental groups. Researchers are often not only interested in identifying differentially expressed genes between a given pair of experimental groups, but are also interested in making directional inferences such as whether a gene is up-or downregulated in one treatment group relative to another. In such situations, in addition to the usual errors such as false positive (Type I error) and false negative (Type II error), one may commit directional error (Type III error). For example, in a dose response microarray study, a gene may be declared to be upregulated in the high dose group compared to the low dose group when it is not. In this paper, we introduce a mixed directional false discovery rate (mdFDR) controlling procedure using weighted p-values to select positives in different directions. The weights are defined as the inverse of two times the proportion of either positive or negative discoveries. The proposed procedure has been proved mathematically to control the mdFDR at level a and to have a larger power (which is defined as the expected proportion of nontrue null hypotheses) than the GSP10 procedure proposed by Guo et al. (2010). Simulation studies and real data analysis are also conducted to show the outperformance of the proposed procedure than the GSP10 procedure.
C1 [Zhao, Haibing] Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai 200433, Peoples R China.
[Peddada, Shyamal D.] Natl Inst Environm Hlth Sci, Biostat Branch, Res Triangle Pk, NC 27709 USA.
[Cui, Xinping] Univ Calif Riverside, Dept Stat, Ctr Plant Cell Biol, Riverside, CA 92521 USA.
RP Cui, XP (reprint author), Univ Calif Riverside, Dept Stat, Ctr Plant Cell Biol, Riverside, CA 92521 USA.
EM xinping.cui@ucr.edu
FU National Natural Science Foundation of China (NSFC) [11101255];
University of California AES-CE RSAP grant [A01869]; NIH, National
Institute of Environmental Health Sciences [Z01 ES101744-04]
FX The research of H.Z. was supported by a grant from the National Natural
Science Foundation of China (NSFC) [No. 11101255]. The research of XC
was supported, in part, by University of California AES-CE RSAP grant
[A01869]. The research of SDP was supported, in part, by the Intramural
Research Program of the NIH, National Institute of Environmental Health
Sciences [Z01 ES101744-04].
NR 30
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0323-3847
EI 1521-4036
J9 BIOMETRICAL J
JI Biom. J.
PD JAN
PY 2015
VL 57
IS 1
SI SI
BP 144
EP 158
DI 10.1002/bimj.201300242
PG 15
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA AY4GO
UT WOS:000347536500011
PM 25410394
ER
PT J
AU Shumchenia, EJ
Pelletier, MC
Cicchetti, G
Davies, S
Pesch, CE
Deacutis, CF
Pryor, M
AF Shumchenia, Emily J.
Pelletier, Marguerite C.
Cicchetti, Giancarlo
Davies, Susan
Pesch, Carol E.
Deacutis, Christopher F.
Pryor, Margherita
TI A Biological Condition Gradient Model for Historical Assessment of
Estuarine Habitat Structure
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Biological condition gradient; Biological assessment; Biological
indicators; Habitat; Resource-based management; Stressors
ID BASE-LINE SYNDROME; NARRAGANSETT BAY; RHODE-ISLAND; MARINE ECOSYSTEMS;
COASTAL; MANAGEMENT; FRAMEWORK; IMPACTS; TEMPERATURE; NUTRIENTS
AB Coastal ecosystems are affected by ever-increasing natural and human pressures. Because the physical, chemical, and biological characteristics unique to estuarine ecosystems control the ways that biological resources respond to ecosystem stressors, we present a flexible and adaptable biological assessment method for estuaries. The biological condition gradient (BCG) is a scientific framework of biological response to increasing anthropogenic stress that is comprehensive and ecosystem based and evaluates environmental conditions and the status of ecosystem services in order to identify, communicate, and prioritize management action. Using existing data, we constructed the first estuarine BCG framework that examines changes in habitat structure through time. Working in a New England (U.S.) estuary with a long history of human influence, we developed an approach to define a reference level, which we described as a "minimally disturbed" range of conditions for the ecosystem, anchored by observations before 1850 AD. Like many estuaries in the U.S., the relative importance of environmental stressors changed over time, but even qualitative descriptions of the biological indicators' status provided useful information for defining condition levels. This BCG demonstrated that stressors rarely acted alone and that declines in one biological indicator influenced the declines of others. By documenting the biological responses to cumulative stressors, the BCG inherently suggests an ecosystem-based approach to management. Additionally, the BCG process initiates thinking over long time scales and can be used to inspire scientists, managers, and the public toward environmental action.
C1 [Shumchenia, Emily J.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett Bay, RI 02882 USA.
[Pelletier, Marguerite C.; Cicchetti, Giancarlo; Pesch, Carol E.] US EPA, Atlantic Ecol Div, Off Res & Dev, Narragansett Bay, RI 02882 USA.
[Davies, Susan] Maine Dept Environm Protect, Augusta, ME 04333 USA.
[Deacutis, Christopher F.] Rhode Isl Dept Environm Management, Div Fish & Wildlife, Jamestown, RI 02835 USA.
[Pryor, Margherita] US EPA, Off Water, Boston, MA 02109 USA.
RP Shumchenia, EJ (reprint author), E&C Enviroscape LLC, Ashaway, RI 02804 USA.
EM emily.shumchenia@gmail.com
FU U.S. EPA Office of Water and Region 1; U.S. EPA
FX This work was funded by the U.S. EPA Office of Water and Region 1.
Although this research was funded by the U.S. EPA, the views expressed
here do not necessarily represent those of the Agency. The authors wish
to thank the participants of both BCG workshops held in Narragansett, RI
and the numerous groups and individuals who have contributed data
regarding the ecology of Narragansett Bay. The ideas and efforts of
these individuals created a foundation for the estuarine BCG framework
and case study. We would also like to thank P. Bradley, R. McKinney, S.
Ayvasian, John Paul, and two anonymous reviewers for thoughtful review
of this manuscript. This is EPA contribution # ORD-003233.
NR 66
TC 1
Z9 1
U1 3
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD JAN
PY 2015
VL 55
IS 1
BP 143
EP 158
DI 10.1007/s00267-014-0401-0
PG 16
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY7BG
UT WOS:000347715600012
PM 25387456
ER
PT J
AU Rhodes, ER
Boczek, LA
Ware, MW
McKay, M
Hoelle, JM
Schoen, M
Villegas, EN
AF Rhodes, Eric R.
Boczek, Laura A.
Ware, Michael W.
McKay, Mary
Hoelle, Jill M.
Schoen, Mary
Villegas, Eric N.
TI Determining Pathogen and Indicator Levels in Class B Municipal Organic
Residuals Used for Land Application
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID MICROBIAL RISK-ASSESSMENT; CRYPTOSPORIDIUM-PARVUM OOCYSTS; WASTE-WATER
TREATMENT; DRINKING-WATER; SEWAGE-SLUDGE; IMMUNOMAGNETIC SEPARATION;
TREATMENT PLANTS; BIOSOLIDS; GIARDIA; CYSTS
AB Biosolids are nutrient-rich organic residuals that are currently used to amend soils for food production. Treatment requirements to inactivate pathogens for production of Class A biosolids are energy intensive. One less energy intensive alternative is to treat biosolids to Class B standards, but it could result in higher pathogen loads. Quantitative microbial risk assessments models have been developed on land application of Class B biosolids but contain many uncertainties because of limited data on specific pathogen densities and the use of fecal indicator organisms as accurate surrogates of pathogen loads. To address this gap, a 12-mo study of the levels and relationships between Cryptosporidium, Giardia, and human adenovirus (HAdV) with fecal coliform, somatic, and F-RNA coliphage levels in Class B biosolids from nine wastewater treatment plants throughout the United States was conducted. Results revealed that fecal coliform, somatic, and F-RNA coliphage densities were consistent throughout the year. More important, results revealed that HAdV ((x) over bar = 2.5 x 10(3) genome copies dry g(-1)) and Giardia ((x) over bar = 4.14 x 103 cysts dry g(-1)) were in all biosolids samples regardless of treatment processes, location, or season. Cryptosporidium oocysts were also detected (38% positive; range: 0-1.9 x 103 oocysts dry g(-1)), albeit sporadically. Positive correlations among three fecal indicator organisms and HAdV, but not protozoa, were also observed. Overall, this study reveals that high concentrations of enteric pathogens (e.g., Cryptosporidium, Giardia, and HAdV) are present in biosolids throughout the United States. Microbial densities found can further assist management and policymakers in establishing more accurate risk assessment models associated with land application of Class B biosolids.
C1 [Rhodes, Eric R.; Ware, Michael W.; McKay, Mary; Schoen, Mary; Villegas, Eric N.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Boczek, Laura A.; Hoelle, Jill M.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Villegas, EN (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM villegas.eric@epa.gov
RI Villegas, Eric/A-7373-2015
OI Villegas, Eric/0000-0002-8059-8588
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX We would like to thank all the POTWs that participated in the study and
Chandler Stevens for technical assistance. We also acknowledge Ron
Hermann and Carolyn Acheson for their scientific discussions. We would
like to thank Asja Korajkic and Mark Meckes for critical review of the
manuscript. The U.S. Environmental Protection Agency through its Office
of Research and Development funded and managed the research described
here. It has been subjected to the Agency's administrative review and
approved for publication. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. Author
contributions: ERR, LAB, MS, and ENV conceived and designed the
experiments; ERR, LAB, MWW, MM, JMH, ENV performed the experiments
and/or collected field samples; ERR, LAB, MWW, MS, and ENV, analyzed the
data; ERR, LAB, MWW, MS, and ENV wrote the paper.
NR 36
TC 3
Z9 3
U1 2
U2 18
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD JAN-FEB
PY 2015
VL 44
IS 1
BP 265
EP 274
DI 10.2134/jeq2014.04.0142
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY8YH
UT WOS:000347836100029
PM 25602342
ER
PT J
AU Rosenbaum, PF
Crawford, JA
Hunt, A
Vesper, SJ
Abraham, JL
AF Rosenbaum, P. F.
Crawford, J. A.
Hunt, A.
Vesper, S. J.
Abraham, J. L.
TI Environmental Relative Moldiness Index and Associations with Home
Characteristics and Infant Wheeze
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
DE ERMI; infants; mold; wheeze
ID QUANTITATIVE PCR ANALYSIS; ASTHMATIC-CHILDREN; 1ST YEAR; COHORT; FUNGI;
MOLD; PREDICTOR; SYRACUSE; EXPOSURE; RISK
AB Possible relationships between mold contamination, as described by the Environmental Relative Moldiness Index (ERMI), home characteristics, and the development of wheeze in the first year of life were evaluated among a cohort of urban infants (n = 103) in Syracuse, New York. Pregnant women with a history of asthma were recruited in 2001-2002 for the "Assessment of Urban Dwellings for Indoor Toxics" (AUDIT) study. When the infants were approximately 3 months of age, a home inspection was carried out and indoor environmental samples collected, including vacuumed house dust. ERMI levels in the Syracuse cohort homes were higher than the U.S. average, with an overall mean of 11.4. ERMI levels were significantly higher in homes with visible water problems (p = 0.023) and visiblemold (p = 0.023). ERMI levels in apartments were significantly lower than the values measured in houses (p = 0.0003). While infants experiencing wheeze (38%) tended to live in homes with higher ERMI values than those without wheeze (ERMI values of 12.3 and 10.9, respectively), the differences did not reach statistical significance. A subset analysis limited to infants with living room samples who remained in the same home during the study (n = 25) was suggestive of an association between higher ERMI values and wheeze (p = 0.10). In summary, the ERMI is a standardized metric which allows for comparison of moldiness levels in homes across studies and regions in the United States. ERMI levels in Syracuse homes were skewed to the high end of the national scale. Higher ERMI levels were indicators of water problems, mold, and type of housing.
C1 [Rosenbaum, P. F.] SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, Syracuse, NY 13210 USA.
[Crawford, J. A.] SUNY Coll Environm Sci & Forestry, Grad Program Environm Sci, Syracuse, NY 13210 USA.
[Hunt, A.] Univ Texas Arlington, Dept Earth & Environm Sci, Arlington, TX 76019 USA.
[Vesper, S. J.] US EPA, Cincinnati, OH 45268 USA.
[Abraham, J. L.] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA.
RP Rosenbaum, PF (reprint author), SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, 750 East Adams St, Syracuse, NY 13210 USA.
EM rosenbap@upstate.edu
FU Environmental Protection Agency [GR828605-01-0]; NYSTAR; Department of
Pathology, SUNY Upstate Medical University, Syracuse, New York
FX Funding for the original AUDIT study was from the Environmental
Protection Agency, Grant # GR828605-01-0. Other sources of funding were
NYSTAR and the Department of Pathology, SUNY Upstate Medical University,
Syracuse, New York.
NR 29
TC 2
Z9 2
U1 1
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1545-9624
EI 1545-9632
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PD JAN
PY 2015
VL 12
IS 1
BP 29
EP 36
DI 10.1080/15459624.2014.933958
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AZ1ZJ
UT WOS:000348033600004
PM 25068535
ER
PT J
AU Wahman, DG
Speitel, GE
AF Wahman, David G.
Speitel, Gerald E., Jr.
TI Hydroxylamine addition impact to Nitrosomonas europaea activity in the
presence of monochloramine
SO WATER RESEARCH
LA English
DT Article
DE Hydroxylamine; Monochloramine; Drinking water; Nitrification;
Nitrosornonas europaea
ID MONOAZIDE QUANTITATIVE PCR; LIVE/DEAD BACLIGHT METHODS; DRINKING-WATER
CONDITIONS; DISINFECTION KINETICS; CHLORAMINE; NITRIFICATION;
INACTIVATION; OXIDATION
AB In drinking water, monochloramine may promote ammonia-oxidizing bacteria (AOB) growth because of concurrent ammonia presence. AOB use (i) ammonia monooxygenase for biological ammonia oxidation to hydroxylamine and (ii) hydroxylamine oxidoreductase for biological hydroxylamine oxidation to nitrite. In addition, monochloramine and hydroxylamine abiotically react, providing AOB a potential benefit by removing the disinfectant (monochloramine) and releasing growth substrate (ammonia). Alternatively and because biological hydroxylamine oxidation supplies the electrons (reductant) required for biological ammonia oxidation, the monochloramine/hydroxylamine abiotic reaction represents a possible inactivation mechanism by consuming hydroxylamine and inhibiting reductant generation. To investigate the abiotic monochloramine and hydroxylamine reaction's impact on AOB activity, the current study used batch experiments with Nitrosomonas europaea (AOB pure culture), ammonia, monochloramine, and hydroxylamine addition. To decipher whether hydroxylamine addition benefitted N. europaea activity by (i) removing monochloramine and releasing free ammonia or (ii) providing an additional effect (possibly the aforementioned reductant source), a previously developed cometabolism model was coupled with an abiotic monochloramine and hydroxylamine model for data interpretation. N. europaea maintained ammonia oxidizing activity when hydroxylamine was added before complete ammonia oxidation cessation. The impact could not be accounted for by monochloramine removal and free ammonia release alone and was concentration dependent for both monochloramine and hydroxylamine. In addition, a preferential negative impact occurred for ammonia versus hydroxylamine oxidation. These results suggest an additional benefit of exogenous hydroxylamine addition beyond monochloramine removal and free ammonia release, possibly providing reductant generation. Published by Elsevier Ltd.
C1 [Wahman, David G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Speitel, Gerald E., Jr.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA.
RP Wahman, DG (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM wahman.david@epa.gov
NR 31
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U1 2
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD JAN 1
PY 2015
VL 68
BP 719
EP 730
DI 10.1016/j.watres.2014.10.054
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AY7RO
UT WOS:000347756900065
PM 25462776
ER
PT J
AU King, KE
Clarke, PJ
AF King, Katherine E.
Clarke, Philippa J.
TI A Disadvantaged Advantage in Walkability: Findings From Socioeconomic
and Geographical Analysis of National Built Environment Data in the
United States
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE built environment; census tracts; health disparities; sociodemographic
factors; urban form; walkability
ID PHYSICAL-ACTIVITY; AIR-POLLUTION; LAND-USE; PUBLIC-HEALTH; NEIGHBORHOOD
CHARACTERISTICS; URBAN FORM; DISPARITIES; POPULATIONS; INTERVENTIONS;
AVAILABILITY
AB Urban form-the structure of the built environment-can influence physical activity, yet little is known about how walkable design differs according to neighborhood sociodemographic composition. We studied how walkable urban form varies by neighborhood sociodemographic composition, region, and urbanicity across the United States. Using linear regression models and 2000-2001 US Census data, we investigated the relationship between 5 neighborhood census characteristics (income, education, racial/ethnic composition, age distribution, and sex) and 5 walkability indicators in almost 65,000 census tracts in 48 states and the District of Columbia. Data on the built environment were obtained from the RAND Corporation's (Santa Monica, California) Center for Population Health and Health Disparities (median block length, street segment, and node density) and the US Geological Survey's National Land Cover Database (proportion open space and proportion highly developed). Disadvantaged neighborhoods and those with more educated residents were more walkable (i.e., shorter block length, greater street node density, more developed land use, and higher density of street segments). However, tracts with a higher proportion of children and older adults were less walkable (fewer street nodes and lower density of street segments), after adjustment for region and level of urbanicity. Research and policy on the walkability-health link should give nuanced attention to the gap between persons living in walkable areas and those for whom walkability has the most to offer.
C1 [King, Katherine E.] US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
RP King, KE (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM kk183@duke.edu
FU Research Participation Program of the Environmental Protection Agency
(Office of Research and Development); Eunice Kennedy Shriver National
Institute of Child Health and Human Development [R24 HD041028]
FX This work was supported in part by an appointment to the Research
Participation Program of the Environmental Protection Agency (Office of
Research and Development), administered by the Oak Ridge Institute for
Science and Education (Oak Ridge, Tennessee) through an interagency
agreement between the US Department of Energy and the Environmental
Protection Agency.; We appreciate the use of the services and facilities
of the Population Studies Center at the University of Michigan (Ann
Arbor, Michigan), which is supported by Center Grant R24 HD041028 from
the Eunice Kennedy Shriver National Institute of Child Health and Human
Development.
NR 89
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U1 8
U2 39
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2015
VL 181
IS 1
BP 17
EP 25
DI 10.1093/aje/kwu310
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY2JF
UT WOS:000347414700002
PM 25414159
ER
PT J
AU King, KE
AF King, Katherine E.
TI Dr. King Responds to "History of Place, Life Course, and Health
Inequalities"
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Editorial Material
C1 US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
RP King, KE (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM kk183@duke.edu
NR 2
TC 1
Z9 1
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2015
VL 181
IS 1
BP 30
EP 31
DI 10.1093/aje/kwu315
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY2JF
UT WOS:000347414700004
PM 25414160
ER
PT J
AU Buse, HY
Lu, JR
Ashbolt, NJ
AF Buse, Helen Y.
Lu, Jingrang
Ashbolt, Nicholas J.
TI Exposure to Synthetic Gray Water Inhibits Amoeba Encystation and Alters
Expression of Legionella pneumophila Virulence Genes
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID FREE-LIVING AMEBAS; ON-SITE TREATMENT; ACANTHAMOEBA-CASTELLANII;
GREYWATER REUSE; HARTMANNELLA-VERMIFORMIS; RESISTING BACTERIA; DOMESTIC
GREYWATER; MICROBIAL QUALITY; ESCHERICHIA-COLI; SECRETION SYSTEM
AB Water conservation efforts have focused on gray water (GW) usage, especially for applications that do not require potable water quality. However, there is a need to better understand environmental pathogens and their free-living amoeba (FLA) hosts within GW, given their growth potential in stored gray water. Using synthetic gray water (sGW) we examined three strains of the waterbased pathogen Legionella pneumophila and its FLA hosts Acanthamoeba polyphaga, A. castellanii, and Vermamoeba vermiformis. Exposure to sGW for 72 h resulted in significant inhibition (P < 0.0001) of amoebal encystation versus control-treated cells, with the following percentages of cysts in sGW versus controls: A. polyphaga (0.6 versus 6%), A. castellanii (2 versus 62%), and V. vermiformis (1 versus 92%), suggesting sGW induced maintenance of the actively feeding trophozoite form. During sGW exposure, L. pneumophila culturability decreased as early as 5 h (1.3 to 2.9 log(10) CFU, P < 0.001) compared to controls (Delta 0 to 0.1 log(10) CFU) with flow cytometric analysis revealing immediate changes in membrane permeability. Furthermore, reverse transcription-quantitative PCR was performed on total RNA isolated from L. pneumophila cells at 0 to 48 h after sGW incubation, and genes associated with virulence (gacA, lirR, csrA, pla, and sidF), the type IV secretion system (lvrB and lvrE), and metabolism (ccmF and lolA) were all shown to be differentially expressed. These results suggest that conditions within GW may promote interactions between water-based pathogens and FLA hosts, through amoebal encystment inhibition and alteration of bacterial gene expression, thus warranting further exploration into FLA and L. pneumophila behavior in GW systems.
C1 [Buse, Helen Y.] Dynamac Corp, Cincinnati, OH USA.
[Lu, Jingrang; Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Buse, HY (reprint author), Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
EM buse.helen@epa.gov
NR 62
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U1 4
U2 18
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JAN
PY 2015
VL 81
IS 2
BP 630
EP 639
DI 10.1128/AEM.03394-14
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AY1UL
UT WOS:000347377500019
PM 25381242
ER
PT J
AU Attene-Ramos, MS
Huang, RL
Michael, S
Witt, KL
Richard, A
Tice, RR
Simeonov, A
Austin, CP
Xia, MH
AF Attene-Ramos, Matias S.
Huang, Ruili
Michael, Sam
Witt, Kristine L.
Richard, Ann
Tice, Raymond R.
Simeonov, Anton
Austin, Christopher P.
Xia, Menghang
TI Profiling of the Tox21 Chemical Collection for Mitochondrial Function to
Identify Compounds that Acutely Decrease Mitochondrial Membrane
Potential
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID CYTOCHROME-C RELEASE; OXIDATIVE-PHOSPHORYLATION; ENVIRONMENTAL
CHEMICALS; LEUKEMIA-CELLS; DYSFUNCTION; MECHANISM; TOXICITY; APOPTOSIS;
BRYOSTATIN-1; CYTOTOXICITY
AB BACKGROUND: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases.
OBJECTIVES: We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (similar to 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells.
RESULTS: Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cyto-toxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay <= 3; p < 0.05]. More than 11% of the structural clusters that constitute the Tox21 library (76 of 651 clusters) were significantly enriched for compounds that decreased the MMP.
CONCLUSIONS: Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity.
C1 [Attene-Ramos, Matias S.; Huang, Ruili; Michael, Sam; Simeonov, Anton; Austin, Christopher P.; Xia, Menghang] NIH, Natl Ctr Advancing Translat Sci, US Dept HHS, Bethesda, MD 20892 USA.
[Witt, Kristine L.; Tice, Raymond R.] NIEHS, Div Natl Toxicol Program, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Richard, Ann] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Xia, MH (reprint author), NIH, Natl Ctr Advancing Translat Sci, 9800 Med Ctr Dr, Bethesda, MD 20892 USA.
EM mxia@mail.nih.gov
FU National Institute of Environmental Health Sciences (NIEHS)/Division of
the National Toxicology Program [IAG Y2-ES-7020-01]
FX This work was supported through interagency agreement IAG Y2-ES-7020-01
from the National Institute of Environmental Health Sciences
(NIEHS)/Division of the National Toxicology Program to the National
Center for Advancing Translational Sciences, NIH.
NR 45
TC 13
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U1 5
U2 21
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2015
VL 123
IS 1
BP 49
EP 56
DI 10.1289/ehp.1408642
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YF
UT WOS:000347385000013
PM 25302578
ER
PT J
AU Zhang, XS
Izaurralde, RC
Manowitz, DH
Sahajpal, R
West, TO
Thomson, AM
Xu, M
Zhao, K
LeDuc, SD
Williams, JR
AF Zhang, Xuesong
Izaurralde, Roberto C.
Manowitz, David H.
Sahajpal, Ritvik
West, Tristram O.
Thomson, Allison M.
Xu, Min
Zhao, Kaiguang
LeDuc, Stephen D.
Williams, Jimmy R.
TI Regional scale cropland carbon budgets: Evaluating a geospatial
agricultural modeling system using inventory data
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Agriculture; Carbon; Climate change; EPIC; Geospatial modeling; Parallel
computing
ID CLIMATE-CHANGE IMPACTS; ORGANIC-CARBON; INTEGRATED ASSESSMENT; SOIL
CARBON; LONG-TERM; CONTERMINOUS USA; UNITED-STATES; RIVER-BASIN;
LAND-USE; DYNAMICS
AB Accurate quantification and clear understanding of regional scale cropland carbon (C) cycling is critical for designing effective policies and management practices that can contribute toward stabilizing atmospheric CO2 concentrations. However, extrapolating site-scale observations to regional scales represents a major challenge confronting the agricultural modeling community. This study introduces a novel geospatial agricultural modeling system (GAMS) exploring the integration of the mechanistic Environmental Policy Integrated Climate model, spatially-resolved data, surveyed management data, and supercomputing functions for cropland C budgets estimates. This modeling system creates spatially-explicit modeling units at a spatial resolution consistent with remotely-sensed crop identification and assigns cropping systems to each of them by geo-referencing surveyed crop management information at the county or state level. A parallel computing algorithm was also developed to facilitate the computationally intensive model runs and output post-processing and visualization. We evaluated GAMS against National Agricultural Statistics Service (NASS) reported crop yields and inventory estimated county-scale cropland C budgets averaged over 2000-2008. We observed good overall agreement, with spatial correlation of 0.89, 0.90, 0.41, and 0.87, for crop yields, Net Primary Production (NPP), Soil Organic C (SOC) change, and Net Ecosystem Exchange (NEE), respectively. However, we also detected notable differences in the magnitude of NPP and NEE, as well as in the spatial pattern of SOC change. By performing crop-specific annual comparisons, we discuss possible explanations for the discrepancies between GAMS and the inventory method, such as data requirements, representation of agroecosystem processes, completeness and accuracy of crop management data, and accuracy of crop area representation. Based on these analyses, we further discuss strategies to improve GAMS by updating input data and by designing more efficient parallel computing capability to quantitatively assess errors associated with the simulation of C budget components. The modularized design of the GAMS makes it flexible to be updated and adapted for different agricultural models so long as they require similar input data, and to be linked with socio-economic models to understand the effectiveness and implications of diverse C management practices and policies. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Zhang, Xuesong; Manowitz, David H.; West, Tristram O.; Thomson, Allison M.] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA.
[Zhang, Xuesong; Manowitz, David H.; West, Tristram O.; Thomson, Allison M.] Univ Maryland, College Pk, MD 20740 USA.
[Izaurralde, Roberto C.; Sahajpal, Ritvik] Univ Maryland, Dept Geog Sci, College Pk, MD 20740 USA.
[Xu, Min] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
[Zhao, Kaiguang] Ohio State Univ, Sch Environm & Nat Resources, Ohio Agr Res & Dev Ctr, Wooster, OH 44691 USA.
[LeDuc, Stephen D.] US EPA, Natl Ctr Environm Assessment, Arlington, VA 22202 USA.
[Izaurralde, Roberto C.; Williams, Jimmy R.] Texas A&M AgriLife Res & Extens Ctr, Temple, TX 76502 USA.
RP Zhang, XS (reprint author), Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA.
EM xuesong.zhang@pnnl.gov
RI zhang, xuesong/B-7907-2009; Zhao, Kaiguang/D-1172-2010;
OI Xu, Min/0000-0003-3443-0300
FU DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science)
[DE-FC02-07ER64494, KP1601050, DOE EERE OBP 20469-19145]; NASA, North
American Carbon Program [NNH12AU03I]; New Investigator Program (NIP)
[NNH13ZDA001N]
FX We sincerely appreciate the valuable comments provided by the three
anonymous reviewers, which have greatly improved the quality of this
manuscript. This work was partially funded by the DOE Great Lakes
Bioenergy Research Center (DOE BER Office of Science DE-FC02-07ER64494,
DOE BER Office of Science KP1601050, DOE EERE OBP 20469-19145), and NASA
as part of the North American Carbon Program (NNH12AU03I) and the New
Investigator Program (NIP) (NNH13ZDA001N). The views expressed here are
those of the authors and do not necessarily represent the views or
policies of the U.S. Environmental Protection Agency.
NR 78
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U1 2
U2 38
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD JAN
PY 2015
VL 63
BP 199
EP 216
DI 10.1016/j.envsoft.2014.10.005
PG 18
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA AY1OT
UT WOS:000347362900016
ER
PT J
AU Sengupta, D
Mukherjee, R
Sikdar, SK
AF Sengupta, Debalina
Mukherjee, Rajib
Sikdar, Subhas K.
TI Environmental Sustainability of Countries Using the UN MDG Indicators by
Multivariate Statistical Methods
SO ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
LA English
DT Article
DE Aggregate Index Method; Euclidean Distance Method; Partial Least Squares
Variable Importance in Projection; United Nations Millennium Development
Goals; sustainability; sustainability indicators
AB The objective of the article is to show that indicator aggregation coupled with the use of a multivariate statistical analysis applied to the environmental sustainability indicator data of the UN Millennium Goals (MDG) can allow important inferences to be made. Goal 7 of the UN MDG aims to assess environmental sustainability by ten indicators, the dominant among them being emissions of carbon dioxide equivalent. The data is available over a period of 20 years. We used an aggregate index method to combine the various indicator values into a single index, and studied the trends of countries over the years. We have also compared among two arbitrarily chosen groups of OECD and non-OECD countries, and shown how these countries have performed among themselves and as a combined group over the time period. Using the multivariate statistical method of Partial Least Squares Variable Importance in Projection (PLS-VIP), we showed how to find the key indicators from the larger set and their relative importance over the years. Important results from our research include ranking of countries according to their overall environmental performance in a particular group. The PLS-VIP method showed that certain indicators have shifted in their importance in influencing their overall environmental performance, while others have remained relatively insignificant over the 20-year period. 2014 American Institute of Chemical Engineers Environ Prog, 2014 (c) 2014 American Institute of Chemical Engineers Environ Prog, 34: 198-206, 2015
C1 [Sengupta, Debalina; Mukherjee, Rajib; Sikdar, Subhas K.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sikdar, SK (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM sikdar.subhas@epa.gov
FU EPA Office of Research and Development; Office of Research and
Development, National Risk Management Research Laboratory, U.S.
Environmental Protection Agency
FX The work presented here was funded by the EPA Office of Research and
Development. This project was supported in part by an appointment to the
Research Participation Program at the Office of Research and
Development, National Risk Management Research Laboratory, U.S.
Environmental Protection Agency, administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and EPA. The supplementary information
provided with this paper contains an excel spreadsheet where a reader
can access the data used to generate the figures in this paper. The
Matlab (R) code used to generate the data is available upon request from
the authors.
NR 16
TC 6
Z9 6
U1 1
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1944-7442
EI 1944-7450
J9 ENVIRON PROG SUSTAIN
JI Environ. Prog. Sustain. Energy
PD JAN
PY 2015
VL 34
IS 1
BP 198
EP 206
DI 10.1002/ep.11963
PG 9
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Engineering, Chemical; Engineering, Industrial; Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA AY1CP
UT WOS:000347331300025
ER
PT J
AU Lockey, JE
Redlich, CA
Streicher, R
Pfahles-Hutchens, A
Hakkinen, PJ
Ellison, GL
Harber, P
Utell, M
Holland, J
Comai, A
White, M
AF Lockey, James E.
Redlich, Carrie A.
Streicher, Robert
Pfahles-Hutchens, Andrea
Hakkinen, Pertti (Bert) J.
Ellison, Gary L.
Harber, Philip
Utell, Mark
Holland, John
Comai, Andrew
White, Marc
TI Isocyanates and Human Health Multistakeholder Information Needs and
Research Priorities
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID METHYLENE DIPHENYL DIISOCYANATE; COLLISION REPAIR INDUSTRY; OCCUPATIONAL
ASTHMA; TOLUENE DIISOCYANATE; EXPOSURE LIMITS; SKIN EXPOSURE;
POLYURETHANE; SURVEILLANCE
AB Objectives: To outline the knowledge gaps and research priorities identified by a broad base of stakeholders involved in the planning and participation of an international conference and research agenda workshop on isocyanates and human health held in Potomac, Maryland, in April 2013. Methods: A multimodal iterative approach was used for data collection including preconference surveys, review of a 2001 consensus conference on isocyanates, oral and poster presentations, focused break-out sessions, panel discussions, and postconference research agenda workshop. Results: Participants included representatives of consumer and worker health, health professionals, regulatory agencies, academic and industry scientists, labor, and trade associations. Conclusions: Recommendations were summarized regarding knowledge gaps and research priorities in the following areas: worker and consumer exposures; toxicology, animal models, and biomarkers; human cancer risk; environmental exposure and monitoring; and respiratory epidemiology and disease, and occupational health surveillance.
C1 [Lockey, James E.] Univ Cincinnati, Div Occupat & Environm Med, Dept Environm Hlth, Pulm Div,Dept Internal Med,Coll Med, Cincinnati, OH 45267 USA.
[Redlich, Carrie A.] Yale Univ, Sch Med, Yale Occupat & Environm Med, New Haven, CT USA.
[Streicher, Robert] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Pfahles-Hutchens, Andrea] US EPA, Risk Assessment Div, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
[Hakkinen, Pertti (Bert) J.] NIH, Off Clin Toxicol, Specialized Informat Serv, Natl Lib Med, Bethesda, MD 20892 USA.
[Ellison, Gary L.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Harber, Philip] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA.
[Utell, Mark] Univ Rochester, Med Ctr, Rochester, NY 14627 USA.
[Holland, John] Holland Associates, Palo Alto, CA USA.
[Comai, Andrew] UAW Hlth & Safety, Int Union, Detroit, MI USA.
[White, Marc] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 1M9, Canada.
[White, Marc] Canadian Inst Relief Pain & Disabil, Vancouver, BC, Canada.
RP Lockey, JE (reprint author), Univ Cincinnati, Coll Med, Div Occupat & Environm Med, Dept Environm Hlth, 3223 Eden Ave, Cincinnati, OH 45267 USA.
EM lockeyje@ucmail.uc.edu
RI White, Marc/N-8404-2015; Hakkinen, Pertti/G-4803-2016;
OI Hakkinen, Pertti/0000-0002-8295-9738; White, Marc/0000-0001-7623-1268
FU National Institutes of Health, National Cancer Institute; Canadian
Institutes for Health Research-Institute of Cancer Research; University
of Cincinnati College of Medicine
FX National Institutes of Health, National Cancer Institute; Canadian
Institutes for Health Research-Institute of Cancer Research; and
University of Cincinnati College of Medicine.
NR 30
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U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2015
VL 57
IS 1
BP 44
EP 51
DI 10.1097/JOM.0000000000000278
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY3IP
UT WOS:000347477900010
PM 25563538
ER
PT J
AU Daston, G
Knight, DJ
Schwarz, M
Gocht, T
Thomas, RS
Mahony, C
Whelan, M
AF Daston, George
Knight, Derek J.
Schwarz, Michael
Gocht, Tilman
Thomas, Russell S.
Mahony, Catherine
Whelan, Maurice
TI SEURAT: Safety Evaluation Ultimately Replacing Animal
Testing-Recommendations for future research in the field of predictive
toxicology
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Critical biological targets; Adverse outcome pathways; Safety
assessment; Read-across; Ab initio prediction
ID HEALTH-RISK ASSESSMENT; TOXCAST PROGRAM; FRAMEWORK; CHEMICALS; UPDATE;
READ
AB The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained in SEURAT-1 and appreciating international advancement in both basic and regulatory science, we reflect here on how SEURAT should evolve and propose that further research and development should be directed along two complementary and interconnecting work streams. The first work stream would focus on developing new 'paradigm' approaches for regulatory science. The goal here is the identification of 'critical biological targets' relevant for toxicity and to test their suitability to be used as anchors for predicting toxicity. The second work stream would focus on integration and application of new approach methods for hazard (and risk) assessment within the current regulatory 'paradigm', aiming for acceptance of animal-free testing strategies by regulatory authorities (i.e. translating scientific achievements into regulation). Components for both work streams are discussed and may provide a structure for a future research programme in the field of predictive toxicology.
C1 [Daston, George] Procter & Gamble Co, Cent Prod Safety Dept, Mason, OH 45040 USA.
[Knight, Derek J.] European Chem Agcy, Helsinki 00121, Finland.
[Schwarz, Michael; Gocht, Tilman] Univ Tubingen, Dept Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-72074 Tubingen, Germany.
[Thomas, Russell S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Mahony, Catherine] Procter & Gamble Tech Ctr Ltd, Egham TW20 9NW, Surrey, England.
[Whelan, Maurice] Commiss European Communities, Joint Res Ctr, IHCP, I-21027 Ispra, VA, Italy.
RP Schwarz, M (reprint author), Univ Tubingen, Dept Toxicol, Inst Expt & Clin Pharmacol & Toxicol, Wilhelmstr 56, D-72074 Tubingen, Germany.
EM Michael.schwarz@uni-tuebingen.de
OI Gocht, Tilma/0000-0002-2491-2050
FU European Community [267044]; Cosmetics Europe
FX This work has received funding from the European Community's Seventh
Framework Programme (FP7/2007-2013) under grant agreement no 267044
(project acronym 'COACH') and has received financing from Cosmetics
Europe.
NR 22
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PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD JAN
PY 2015
VL 89
IS 1
BP 15
EP 23
DI 10.1007/s00204-014-1421-5
PG 9
WC Toxicology
SC Toxicology
GA AY0KZ
UT WOS:000347286700003
PM 25433540
ER
PT J
AU Lorber, M
Eaglesham, GE
Hobson, P
Toms, LML
Mueller, JF
Thompson, JS
AF Lorber, M.
Eaglesham, G. E.
Hobson, P.
Toms, L. -M. L.
Mueller, J. F.
Thompson, J. S.
TI The effect of ongoing blood loss on human serum concentrations of
perfluorinated acids
SO CHEMOSPHERE
LA English
DT Article
DE PFOS; PFOA; Menstruation; Elimination; Blood loss; PK model
ID PERFLUOROOCTANE SULFONATE; WOMEN; POPULATION; AMERICANS; EXPOSURE
AB Perfluorinated alkyl acids (PFAAs) have been detected in serum at low concentrations in background populations. Higher concentrations haven been observed in adult males compared to females, with a possible explanation that menstruation offers females an additional elimination route. In this study, we examined the significance of blood loss as an elimination route of PFAAs. Pooled serum samples were collected from individuals undergoing a medical procedure involving ongoing blood withdrawal called venesection, Concentrations from male venesection patients were approximately 40% lower than males in the general population for perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). A simple pharmacokinetic model was used to test the hypothesis that blood loss could explain why adult males have higher concentrations of PFAAs than females, and why males undergoing venesections had lower concentrations compared to males in the general population. The model application generally supported these hypotheses showing that venesection might reduce blood serum concentrations by 37% (PFOA) and 53% (PFOS) compared to the observed difference of 44% and 37%. Menstruation was modeled to show a 22% reduction in PFOA serum concentrations compared to a 24% difference in concentrations between males and females in the background population. Uncertainties in the modeling and the data are identified and discussed. Published by Elsevier Ltd.
C1 [Lorber, M.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Eaglesham, G. E.] Queensland Hlth & Forens Sci Serv, Special Serv Organ Grp, Coopers Plains, Qld 4108, Australia.
[Hobson, P.] Sullivan Niccolaides Pathol, Indooroopilly, Qld 4068, Australia.
[Toms, L. -M. L.] Queensland Univ Technol, Sch Clin Sci, Brisbane, Qld 4001, Australia.
[Toms, L. -M. L.] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
[Mueller, J. F.; Thompson, J. S.] Univ Queensland, Natl Res Ctr Environm Toxicol Entox, Coopers Plains, Qld 4108, Australia.
RP Lorber, M (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave, Washington, DC 20460 USA.
EM lorber.matthew@epa.gov
RI Mueller, Jochen/C-6241-2008; Toms, Leisa-Maree/C-9530-2009;
OI Toms, Leisa-Maree/0000-0002-1444-1638; Mueller,
Jochen/0000-0002-0000-1973
FU Australian Research Council (ARC) Future Fellowship [FF120100546]; ARC
Discovery Early Career Researcher Award [DE120100161]; Queensland Health
FX J.F. Mueller is funded by Australian Research Council (ARC) Future
Fellowship (FF120100546). L.-M.L. Toms is funded by an ARC Discovery
Early Career Researcher Award (DE120100161). The National Research
Centre for Environmental Toxicology is co-funded by Queensland Health.
The authors are grateful for the statistical support provided by John
Fox of the United States Environmental Protection Agency.
NR 23
TC 9
Z9 9
U1 3
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2015
VL 118
BP 170
EP 177
DI 10.1016/j.chemosphere.2014.07.093
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AX5GC
UT WOS:000346953700024
PM 25180653
ER
PT J
AU Tumburu, L
Andersen, CP
Rygiewicz, PT
Reichman, JR
AF Tumburu, Laxminath
Andersen, Christian P.
Rygiewicz, Paul T.
Reichman, Jay R.
TI PHENOTYPIC AND GENOMIC RESPONSES TO TITANIUM DIOXIDE AND CERIUM OXIDE
NANOPARTICLES IN ARABIDOPSIS GERMINANTS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Arabidopsis thaliana germinants; Transcriptional responses; Development;
Nano-ceria; Nano-titania
ID THALIANA GENE-EXPRESSION; ENGINEERED NANOPARTICLES; CEO2 NANOPARTICLES;
SEED-GERMINATION; DNA-DAMAGE; PLANTS; TOXICITY; STRESS; TIO2; ZNO
AB The effects of exposure to nanoparticles of titanium dioxide (nano-titanium) and cerium oxide (nano-cerium) on gene expression and growth in Arabidopsis thaliana germinants were studied by using microarrays and quantitative real-time polymerase chain reaction (qPCR), and by evaluating germinant phenotypic plasticity. Exposure to 12 d of either nano-titania or nano-ceria altered the regulation of 204 and 142 genes, respectively. Genes induced by the nanoparticles mainly include ontology groups annotated as stimuli responsive, including both abiotic (oxidative stress, salt stress, water transport) and biotic (respiratory burst as a defense against pathogens) stimuli. Further analysis of the differentially expressed genes indicates that both nanoparticles affected a range of metabolic processes (deoxyribonucleic acid [DNA] metabolism, hormone metabolism, tetrapyrrole synthesis, and photosynthesis). Individual exposures to the nanoparticles increased percentages of seeds with emergent radicles, early development of hypocotyls and cotyledons, and those with fully grown leaves. Although there were distinct differences between the nanoparticles in their affect on molecular mechanisms attributable to enhancing germinant growth, both particles altered similar suites of genes related to various pathways and processes related to enhanced growth. Environ Toxicol Chem 2015;34:70-83. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
C1 [Tumburu, Laxminath] Western Ecol Div, Natl Res Council, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR USA.
[Andersen, Christian P.; Rygiewicz, Paul T.; Reichman, Jay R.] Western Ecol Div, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR USA.
RP Tumburu, L (reprint author), Western Ecol Div, Natl Res Council, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR 97333 USA.
EM lax.tumburu@nih.gov
FU US Environmental Protection Agency, Western Ecology Division Laboratory
FX We thank J. Betts for preparing the nanoparticle suspensions and
determining suspension characteristics and L. Pokhrel for helping us
obtain the TEM images and physical diameters of the ENPs. We also thank
the Genomic Research Core, National Health and Environmental Effects
Research Laboratory (NHEERL), US Environmental Protection Agency, for
processing the microarrays. The present study was performed while L.
Tumburu held a National Research Council Research Associateship Award at
the US Environmental Protection Agency, Western Ecology Division
Laboratory.
NR 48
TC 7
Z9 7
U1 5
U2 50
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2015
VL 34
IS 1
BP 70
EP 83
DI 10.1002/etc.2756
PG 14
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AX2QT
UT WOS:000346789800010
PM 25242526
ER
PT J
AU Johnson, BR
Weaver, PC
Nietch, CT
Lazorchak, JM
Struewing, KA
Funk, DH
AF Johnson, Brent R.
Weaver, Paul C.
Nietch, Christopher T.
Lazorchak, James M.
Struewing, Katherine A.
Funk, David H.
TI ELEVATED MAJOR ION CONCENTRATIONS INHIBIT LARVAL MAYFLY GROWTH AND
DEVELOPMENT
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Centroptilum; Conductivity; Neocloeon; Total dissolved solids; Toxicity
ID FRESH-WATER INVERTEBRATES; CENTROPTILUM-TRIANGULIFER; COAL-MINE;
TOXICITY; STREAM; EPHEMEROPTERA; BIOASSAYS; RESPONSES; SALINITY;
EXPOSURE
AB Anthropogenic disturbances, including those from developing energy resources, can alter stream chemistry significantly by elevating total dissolved solids. Field studies have indicated that mayflies (Order Ephemeroptera) are particularly sensitive to high total dissolved solids. In the present study, the authors measured 20-d growth and survivorship of larval Neocloeon triangulifer exposed to a gradient of brine salt (mixed NaCl and CaCl2) concentrations. Daily growth rates were reduced significantly in all salt concentrations above the control (363 mu Scm(-1)) and larvae in treatments with specific conductance >812 mu Scm(-1) were in comparatively earlier developmental stages (instars) at the end of the experiment. Survivorship declined significantly when specific conductance was >1513 mu Scm(-1) and the calculated 20-d 50% lethal concentration was 2866 mu Scm(-1). The present study's results provide strong experimental evidence that elevated ion concentrations similar to those observed in developing energy resources, such as oil and gas drilling or coal mining, can adversely affect sensitive aquatic insect species. Environ Toxicol Chem 2015;34:167-172. (c) 2014 SETAC
C1 [Johnson, Brent R.; Lazorchak, James M.] Natl Exposure Res Lab, United States Environm Protect Agcy, Cincinnati, OH USA.
[Weaver, Paul C.; Struewing, Katherine A.] McConnell Grp, Cincinnati, OH USA.
[Nietch, Christopher T.] Natl Risk Management Lab, United States Environm Protect Agcy, Cincinnati, OH USA.
[Funk, David H.] Stroud Water Res Ctr, Avondale, PA USA.
RP Johnson, BR (reprint author), Natl Exposure Res Lab, United States Environm Protect Agcy, Cincinnati, OH 45268 USA.
EM johnson.brent@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
NR 38
TC 6
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U1 8
U2 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2015
VL 34
IS 1
BP 167
EP 172
DI 10.1002/etc.2777
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AX2QT
UT WOS:000346789800021
PM 25307284
ER
PT J
AU Sanchez-Huerta, K
Pacheco-Rosado, J
Gilbert, ME
AF Sanchez-Huerta, K.
Pacheco-Rosado, J.
Gilbert, M. E.
TI Adult Onset-Hypothyroidism: Alterations in Hippocampal Field Potentials
in the Dentate Gyrus are Largely Associated with Anaesthesia-Induced
Hypothermia
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE thyroid; propylthiouracil; adult onset hypothryoidism; hippocampus;
synaptic transmission; hypothermia
ID LONG-TERM POTENTIATION; IMPAIRS SYNAPTIC-TRANSMISSION; THYROID-HORMONE
INSUFFICIENCY; BRAIN TEMPERATURE; RAT HIPPOCAMPUS; PROPYLTHIOURACIL;
PLASTICITY; PATHWAY; LTP; CA1
AB Thyroid hormone (TH) is essential for a number of physiological processes and is particularly critical during nervous system development. The hippocampus is strongly implicated in cognition and is sensitive to developmental hypothyroidism. The impact of TH insufficiency in the foetus and neonate on hippocampal synaptic function has been fairly well characterised. Although adult onset hypothyroidism has also been associated with impairments in cognitive function, studies of hippocampal synaptic function with late onset hypothyroidism have yielded inconsistent results. In the present study, we report hypothyroidism induced by the synthesis inhibitor propylthiouracil (10p.p.m., 0.001%, minimum of 4weeks), resulted in marginal alterations in excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude in the dentate gyrus measured in vivo. No effects were seen in tests of short-term plasticity, and a minor enhancement of long-term potentiation of the EPSP slope was observed. The most robust synaptic alteration evident in hypothyroid animals was an increase in synaptic response latency, which was paralleled by a failure to maintain normal body temperature under anaesthesia, despite warming on a heating pad. Latency shifts could be reversed in hypothyroid animals by increasing the external heat source and, conversely, synaptic delays could be induced in control animals by removing the heat source, with a consequent drop in body and brain temperature. Thermoregulation is TH- dependent, and anaesthesia necessary for surgical procedures posed a thermoregulatory challenge that was differentially met in control and hypothyroid animals. Minor increases in field potential EPSP slope, decreases in PS amplitudes and increased latencies are consistent with previous reports of hypothermia in naive control rats. We conclude that failures in thyroid-dependent temperature regulation rather than direct action of TH in synaptic physiology are responsible for the observed effects. These findings stand in contrast to the synaptic impairments observed in adult offspring following developmental TH insufficiency, and emphasise the need to control for the potential unintended consequences of hypothermia in the interpretation of hypothyroid-induced changes in physiological systems, most notably synaptic transmission.
C1 [Sanchez-Huerta, K.; Pacheco-Rosado, J.] IPN, Dept Fisiol Mauricio Russek, Escuela Nacl Ciencias Biol, Mexico City 07738, DF, Mexico.
[Gilbert, M. E.] US EPA, Tox Assessment Div, Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA.
[Sanchez-Huerta, K.; Pacheco-Rosado, J.] Natl Inst Pediat, Lab Neurochem, Mexico City, DF, Mexico.
RP Gilbert, ME (reprint author), US EPA, Tox Assessment Div MD B105 05, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM gilbert.mary@epa.gov
NR 42
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U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD JAN
PY 2015
VL 27
IS 1
BP 8
EP 19
DI 10.1111/jne.12229
PG 12
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AX1XC
UT WOS:000346735900002
PM 25327136
ER
PT J
AU Ogg, C
AF Ogg, Clayton
TI Compliance programs' feasibility for reducing worldwide loss of forests
and other ecosystems
SO JOURNAL OF SOIL AND WATER CONSERVATION
LA English
DT Editorial Material
C1 [Ogg, Clayton] USDA, Washington, DC USA.
[Ogg, Clayton] US EPA, Washington, DC USA.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU SOIL WATER CONSERVATION SOC
PI ANKENY
PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA
SN 0022-4561
EI 1941-3300
J9 J SOIL WATER CONSERV
JI J. Soil Water Conserv.
PD JAN-FEB
PY 2015
VL 70
IS 1
BP 19A
EP 22A
DI 10.2489/jswc.70.1.19A
PG 4
WC Ecology; Soil Science; Water Resources
SC Environmental Sciences & Ecology; Agriculture; Water Resources
GA AX8UI
UT WOS:000347183400003
ER
PT J
AU Korner-Nievergelt, F
Behr, O
Brinkmann, R
Etterson, MA
Huso, MMP
Dalthorp, D
Korner-Nievergelt, P
Roth, T
Niermann, I
AF Korner-Nievergelt, Fraenzi
Behr, Oliver
Brinkmann, Robert
Etterson, Matthew A.
Huso, Manuela M. P.
Dalthorp, Dan
Korner-Nievergelt, Pius
Roth, Tobias
Niermann, Ivo
TI Mortality estimation from carcass searches using the R-package carcass -
a tutorial
SO WILDLIFE BIOLOGY
LA English
DT Article
ID WIND FARMS; BAT FATALITY; BIRD; MODELS; PERSISTENCE; HYPOTHESES;
SURVIVAL; AREAS
AB This article is a tutorial for the R-package carcass. It starts with a short overview of common methods used to estimate mortality based on carcass searches. Then, it guides step by step through a simple example. First, the proportion of animals that fall into the search area is estimated. Second, carcass persistence time is estimated based on experimental data. Third, searcher efficiency is estimated. Fourth, these three estimated parameters are combined to obtain the probability that an animal killed is found by an observer. Finally, this probability is used together with the observed number of carcasses found to obtain an estimate for the total number of killed animals together with a credible interval.
C1 [Korner-Nievergelt, Fraenzi; Korner-Nievergelt, Pius] Oikostat GmbH, CH-6218 Ettiswil, Switzerland.
[Korner-Nievergelt, Fraenzi; Korner-Nievergelt, Pius] Swiss Ornithol Inst, Sempach, Switzerland.
[Behr, Oliver] Univ Erlangen Nurnberg, Chair Sensor Technol, DE-91054 Erlangen, Germany.
[Brinkmann, Robert] FrInaT, Freiburg Inst Appl Anim Ecol, DE-79106 Freiburg, Germany.
[Etterson, Matthew A.] US EPA, Duluth, MN 55804 USA.
[Huso, Manuela M. P.; Dalthorp, Dan] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, Corvallis, OR 97331 USA.
[Roth, Tobias] Hintermann & Weber AG, CH-4153 Reinach, Switzerland.
[Niermann, Ivo] Leibniz Univ Hannover, Inst Environm Planning, DE-30419 Hannover, Germany.
RP Korner-Nievergelt, F (reprint author), Oikostat GmbH, Ausserdorf 43, CH-6218 Ettiswil, Switzerland.
EM fraenzi.korner@oikostat.ch
NR 34
TC 6
Z9 6
U1 5
U2 20
PU WILDLIFE BIOLOGY
PI RONDE
PA C/O JAN BERTELSEN, GRENAAVEJ 14, KALO, DK-8410 RONDE, DENMARK
SN 0909-6396
EI 1903-220X
J9 WILDLIFE BIOL
JI Wildlife Biol.
PD JAN
PY 2015
VL 21
IS 1
BP 30
EP 43
DI 10.2981/wlb.00094
PG 14
WC Ecology; Zoology
SC Environmental Sciences & Ecology; Zoology
GA AY2DK
UT WOS:000347398500004
ER
PT J
AU Wu, XM
Bennett, DH
Calafat, AM
Kato, K
Strynar, M
Andersen, E
Moran, RE
Tancredi, DJ
Tulve, NS
Hertz-Picciotto, I
AF Wu, Xiangmei (May)
Bennett, Deborah H.
Calafat, Antonia M.
Kato, Kayoko
Strynar, Mark
Andersen, Erik
Moran, Rebecca E.
Tancredi, Daniel J.
Tulve, Nicolle S.
Hertz-Picciotto, Irva
TI Serum concentrations of perfluorinated compounds (PFC) among selected
populations of children and Adults in California
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Perfluorinated compounds; Serum; Children; Within-family correlation;
Temporal variation
ID NATIONAL BIRTH COHORT; IN-HOUSE DUST; PERFLUOROOCTANE SULFONATE;
POLYFLUOROALKYL COMPOUNDS; POLYFLUORINATED COMPOUNDS; PERFLUOROALKYL
ACIDS; DIETARY EXPOSURE; INDOOR AIR; HALF-LIFE; CHEMICALS
AB Perfluorinated compounds (PFCs) have been widely used in industrial applications and consumer products. Their persistent nature and potential health impacts are of concern. Given the high cost of collecting serum samples, this study is to understand whether we can quantify PFC serum concentrations using factors extracted from questionnaire responses and indirect measurements, and whether a single serum measurement can be used to classify an individual's exposure over a one-year period. The study population included three demographic groups: young children (2-8 years old) (N=67), parents of young children (< 55 years old) (N=90), and older adults ( > 55 years old) (N=59). PFC serum concentrations, house dust concentrations, and questionnaires were collected. The geometric mean of perfluorooctane sulfonic acid (PFOS) was highest for the older adults. In contrast, the geometric mean of perfluorooctanoic acid (PFOA) was highest for children. Serum concentrations of the parent and the child from the same family were moderately correlated (Spearman correlation (r)=0.26-0.79, p <0.05), indicating common sources within a family. For adults, age, having occupational exposure or having used fire extinguisher, frequencies of consuming butter/margarine, pork, canned meat entres, tuna and white fish, freshwater fish, and whether they ate microwave popcorn were significantly positively associated with serum concentrations of individual PFCs. For children, residential dust concentrations, frequency of wearing waterproof clothes, frequency of having canned fish, hotdogs, chicken nuggets, French fries, and chips, and whether they ate microwave popcorn were significant positive predictors of individual PFC serum concentrations. In addition, the serum concentrations collected in a subset of young children (N=20) and the parents (N=42) one year later were strongly correlated (r=0.68-0.98, p <0.001) with the levels measured at the first visits, but showed a decreasing trend. Children had moderate correlation (r=0.43) between serum and dust concentrations. of PFOS, indicating indoor sources contribute to exposure. In conclusion, besides food intake, occupational exposure, consumer product use, and exposure to residential dust contribute to PFC exposure. The downward temporal trend of serum concentrations reflects the reduction of PFCs use in recent years while the year-to-year correlation indicates that a single serum measurement could be an estimate of exposure relative to the population for a one-year period in epidemiology studies. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Wu, Xiangmei (May); Bennett, Deborah H.; Moran, Rebecca E.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Calafat, Antonia M.; Kato, Kayoko] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Strynar, Mark; Andersen, Erik] US EPA, Human Exposure & Atmospher Sci Div, Methods Dev & Applicat Branch, Durham, NC 27711 USA.
[Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA.
[Tulve, Nicolle S.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
RP Wu, XM (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, One Shields Ave,MS1C, Davis, CA 95616 USA.
EM xmwu@phs.ucdavis.edu; dhbennett@ucdavis.edu; aic7@cdc.gov; ktk2@cdc.gov;
Strynar.Mark@epa.gov; andersen.erik@epa.gov; rmoran@ucdavis.edu;
djtancredi@ucdavis.edu; Tulve.Nicolle@epa.gov; ihp@ucdavis.edu
RI Tancredi, Daniel/O-3381-2013
OI Tancredi, Daniel/0000-0002-3884-7907
FU U.S. Environmental Protection Agency (US EPA) [RD-83154001]; Autism
Speaks
FX This research was funded by a Science to Achieve Results (STAR) grant
#RD-83154001 from the U.S. Environmental Protection Agency (US EPA).
Environmental sample analysis was conducted by the U.S. EPA's Office of
Research and Development's National Exposure Research Laboratory, and
blood sample analysis was conducted by the Centers for Disease Control
and Prevention Laboratory (CDC). Data analysis was conducted with
funding from Autism Speaks.
NR 64
TC 16
Z9 16
U1 4
U2 56
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2015
VL 136
BP 264
EP 273
DI 10.1016/j.envres.2014.09.026
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2DY
UT WOS:000346755000033
PM 25460645
ER
PT J
AU Yeh, HC
Lin, YS
Kuo, CC
Weidemann, D
Weaver, V
Fadrowski, J
Neu, A
Navas-Acien, A
AF Yeh, Hung-Chieh
Lin, Yu-Sheng
Kuo, Chin-Chi
Weidemann, Darcy
Weaver, Virginia
Fadrowski, Jeffrey
Neu, Alicia
Navas-Acien, Ana
TI Urine osmolality in the US population: Implications for environmental
biomonitoring
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Urine osmolality; Urine creatinine; Biomonitoring; Urine adequacy; Urine
dilution
ID PROTEIN-OSMOLALITY; ALBUMIN EXCRETION; CREATININE; CHILDREN; DISEASE;
VALIDITY; GUIDE; RATIO
AB Background: For many environmental chemicals, concentrations in spot urine samples are considered valid surrogates of exposure and internal dose. To correct for urine dilution, spot urine concentrations are commonly adjusted for urinary creatinine. There are, however, several concerns about the use of urine creatinine. While urine osmolality is an attractive alternative; its characteristics and determinants in the general population remain unknown. Our objective was to describe the determinants of urine osmolality and to contrast the difference between osmolality and creatinine in urine.
Methods: From the National Health and Nutrition Examination Survey (NHANES) (2009-2010), 10,769 participants aged 16 years or older with measured urine osmolality and creatinine were used in the analysis. Very dilute and very concentrated urine was defined as urine creatinine lower than 0.3 g/l and higher than 3 g/l, respectively. Linear and logistic regression analyses were performed to investigate the associations of interest.
Results: Urine osmolality and creatinine were highly correlated (Pearson correlation coefficient=0.75) and their respective median values were 648 mOsm/kg and 1.07 g/l. The prevalence of very dilute and very concentrated urine samples was 8.1% and 3.1%, respectively. Factors associated in the same direction with both urine osmolality and urine creatinine included age, sex, race, body mass index (BMI), hypertension, water intake, and blood osmolality. The magnitude of associations expressed as percent change was significantly stronger with creatinine than osmolality. Compared to urine creatinine, urine osmolality did not vary by diabetes status but was affected by daily total protein intake. Participants with chronic kidney disease (CKD) had significantly higher urine creatinine concentrations but lower urine osmolality. Both very dilute and concentrated urine were associated with a diverse array of socio-demographic, medical conditions, and dietary factors. For instance, females were approximately 3.3 times more likely to have urine over-dilution than male [the adjusted odds ratios (95% CI)=3.27 (2.10-5.10)].
Conclusion: Although the determinants of urine osmolality were generally similar to those of urine creatinine, the relative influence of socio-demographic and medical conditions was less on urine osmolality than on urine creatinine. Protocols for spot urine sample collection could recommend avoiding excessive and insufficient water intake before urine sampling to improve urine adequacy. The feasibility of adopting urine osmolality adjustment and water intake recommendations before providing spot urine samples for environmental biomonitoring merits further investigation. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, China Med Univ Hosp, Kidney Inst, Taichung, Taiwan.
[Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Nephrol, Taichung, Taiwan.
[Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, Coll Med, Taichung, Taiwan.
[Lin, Yu-Sheng] Univ N Texas, Hlth Sci Ctr, Dept Environm & Occupat Hlth, Ft Worth, TX USA.
[Kuo, Chin-Chi; Weidemann, Darcy; Fadrowski, Jeffrey; Navas-Acien, Ana] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Kuo, Chin-Chi; Weaver, Virginia; Navas-Acien, Ana] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA.
[Kuo, Chin-Chi; Weaver, Virginia; Navas-Acien, Ana] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
[Weidemann, Darcy; Fadrowski, Jeffrey; Neu, Alicia] Johns Hopkins Med Inst, Dept Pediat, Div Nephrol, Baltimore, MD 21205 USA.
RP Kuo, CC (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
FU NIDDK NIH HHS [P30 DK079637]
NR 31
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U1 1
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2015
VL 136
BP 482
EP 490
DI 10.1016/j.envres.2014.09.009
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2DY
UT WOS:000346755000058
PM 25460670
ER
PT J
AU Bateson, TF
Kopylev, L
AF Bateson, Thomas F.
Kopylev, Leonid
TI Influence of exposure assessment and parameterization on exposure
response. Aspects of epidemiologic cohort analysis using the Libby
Amphibole asbestos worker cohort
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE asbestos; exposure assessment; exposure modeling; Libby MT; lung cancer;
vermiculite
ID GUIDE RISK-ASSESSMENT; VERMICULITE MINERS; LUNG-CANCER; OCCUPATIONAL
EXPOSURES; TREMOLITE ACTINOLITE; MATHEMATICAL MODEL; POTENCY FACTORS;
FIBER BURDEN; MORTALITY; QUALITY
AB Recent meta-analyses of occupational epidemiology studies identified two important exposure data quality factors in predicting summary effect measures for asbestos-associated lung cancer mortality risk: sufficiency of job history data and percent coverage of work history by measured exposures. The objective was to evaluate different exposure parameterizations suggested in the asbestos literature using the Libby, MT asbestos worker cohort and to evaluate influences of exposure measurement error caused by historically estimated exposure data on lung cancer risks. Focusing on workers hired after 1959, when job histories were well-known and occupational exposures were predominantly based on measured exposures (85% coverage), we found that cumulative exposure alone, and with allowance of exponential decay, fit lung cancer mortality data similarly. Residence-time-weighted metrics did not fit well. Compared with previous analyses based on the whole cohort of Libby workers hired after 1935, when job histories were less well-known and exposures less frequently measured (47% coverage), our analyses based on higher quality exposure data yielded an effect size as much as 3.6 times higher. Future occupational cohort studies should continue to refine retrospective exposure assessment methods, consider multiple exposure metrics, and explore new methods of maintaining statistical power while minimizing exposure measurement error.
C1 [Bateson, Thomas F.; Kopylev, Leonid] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Bateson, TF (reprint author), US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW,Mailcode 8623P, Washington, DC 20460 USA.
EM bateson.thomas@epa.gov
FU National Center for Environmental Assessment, US Environmental
Protection Agency
FX We are grateful to Patricia Sullivan of the National Institute for
Occupational Safety and Health, Danielle DeVoney of the US EPA's Office
of Solid Waste and Emergency Response and anonymous reviewers. No direct
funding for this work was received from any source; general support for
this work was provided by the National Center for Environmental
Assessment, US Environmental Protection Agency.
NR 34
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U1 1
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2015
VL 25
IS 1
BP 12
EP 17
DI 10.1038/jes.2014.3
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AW7GB
UT WOS:000346431500003
PM 24496219
ER
PT J
AU Davis, MJ
Janke, R
AF Davis, Michael J.
Janke, Robert
TI Influence of Network Model Detail on Estimated Health Effects of
Drinking Water Contamination Events
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT
LA English
DT Article
DE Water distribution systems; Simulation; Water quality; Drinking water;
Public health
ID DISTRIBUTION-SYSTEMS
AB Network model detail can influence the accuracy of results from analyses of water distribution systems. Previous work has shown the limitations of skeletonized network models when considering water quality and hydraulic effects. Loss of model detail is potentially less important for aggregated effects such as the systemwide health effects associated with a contamination event, but has received limited attention. The influence of model detail on such effects is examined here by comparing results obtained for contamination events using three large network models and several skeletonized versions of the models. Loss of model detail decreases the accuracy of estimated aggregated adverse effects related to contamination events. It has the potential to have a large negative influence on the results of consequence assessments and the design of contamination warning systems. However, the adverse influence on analysis results can be minimized by restricting attention to high percentile effects (i.e.,95th percentile or higher).
C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne, IL 60439 USA.
[Janke, Robert] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM mike_davis@anl.gov; janke.robert@epa.gov
FU U.S. Environmental Protection Agency's (EPA's) Office of Research and
Development; EPA under U.S. Department of Energy [DE-AC02-06CH11357]
FX The U.S. Environmental Protection Agency's (EPA's) Office of Research
and Development funded, managed, and participated in the research
described here under an interagency agreement. The views expressed in
this paper are those of the authors and do not necessarily reflect the
views or policies of EPA. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. Work at
Argonne National Laboratory was sponsored by the EPA under an
interagency agreement through U.S. Department of Energy Contract
DE-AC02-06CH11357.
NR 23
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U1 0
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
EI 1943-5452
J9 J WATER RES PLAN MAN
JI J. Water Resour. Plan. Manage.-ASCE
PD JAN
PY 2015
VL 141
IS 1
AR UNSP 04014044
DI 10.1061/(ASCE)WR.1943-5452.0000436
PG 9
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA AW5WX
UT WOS:000346342800003
ER
PT J
AU Weber, MA
Ringold, PL
AF Weber, Matthew A.
Ringold, Paul L.
TI Priority river metrics for residents of an urbanized arid watershed
SO LANDSCAPE AND URBAN PLANNING
LA English
DT Article
DE Qualitative research; Focus groups; Depth interviews; Final ecosystem
services; Urban ecosystem services; River monitoring
ID SENSITIVE TOPICS; DECISION-MAKERS; DESERT CITY; RESTORATION;
PERCEPTIONS; INDICATORS; CORRIDORS; QUALITY; VALUES
AB In river and stream assessment and management, a persistent question is isolating appropriate indicators of resource condition. We employ qualitative research techniques to identify features of rivers and streams important to the general public in an urbanized arid watershed of the southwestern US, based on interview and focus group data. After detailed analysis of transcriptions, findings were member-checked with new study participants and further revised. Theme frequencies are reported to provide an indication of participants' informational priorities. Recurrent ecological themes were Water, Vegetation, and Fish and Wildlife; recurrent human themes were Garbage and Graffiti, Odor, Infrastructure, Other People, and Noise. Themes are further described along with illustrative quotes from participants. We interpret participant input into actionable metrics which could serve to track resource condition. Results are compared to previous research and current monitoring practice. The findings are particularly relevant for scientists and managers interested in the perspectives on rivers and streams held by residents of urbanized watersheds in arid landscapes. Published by Elsevier B.V.
C1 [Weber, Matthew A.; Ringold, Paul L.] US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97333 USA.
RP Weber, MA (reprint author), US EPA, Off Res & Dev, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM weber.matthew@epa.gov; ringold.paul@epa.gov
NR 50
TC 2
Z9 2
U1 5
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-2046
EI 1872-6062
J9 LANDSCAPE URBAN PLAN
JI Landsc. Urban Plan.
PD JAN
PY 2015
VL 133
BP 37
EP 52
DI 10.1016/j.landurbplan.2014.09.006
PG 16
WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban
Studies
SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban
Studies
GA AW8WQ
UT WOS:000346540600004
ER
PT J
AU Henderson, J
Rodgers, C
Jones, R
Smith, J
Strzepek, K
Martinich, J
AF Henderson, James
Rodgers, Charles
Jones, Russell
Smith, Joel
Strzepek, Kenneth
Martinich, Jeremy
TI Economic impacts of climate change on water resources in the coterminous
United States
SO MITIGATION AND ADAPTATION STRATEGIES FOR GLOBAL CHANGE
LA English
DT Article
DE Climate change; Impacts; Economic analysis; Mitigation policy; Water
demand; Water resources; Adaptation
ID CALIFORNIA; MANAGEMENT; RESPONSES; DROUGHT; MODEL
AB A national-scale simulation-optimization model was created to generate estimates of economic impacts associated with changes in water supply and demand as influenced by climate change. Water balances were modeled for the 99 assessment sub-regions, and are presented for 18 water resource regions in the United States. Benefit functions are developed for irrigated agriculture, municipal and domestic water use, commercial and industrial water use, and hydroelectric power generation. Environmental flows below minimal levels required for environmental needs are assessed a penalty. As a demonstration of concept for the model, future climate is projected using a climate model ensemble for two greenhouse gas (GHG) emissions scenarios: a business-as-usual (BAU) scenario in which no new GHG controls are implemented, and an exemplary mitigation policy (POL) scenario in which future GHG emissions are mitigated. Damages are projected to grow less during the 21st century under the POL scenario than the BAU scenario. The largest impacts from climate change are projected to be on non-consumptive uses (e.g., environmental flows and hydropower) and relatively lower-valued consumptive uses (e.g., agriculture), as water is reallocated during reduced water availability conditions to supply domestic, commercial, and industrial uses with higher marginal values. Lower GHG concentrations associated with a mitigation policy will result in a smaller rise in temperature and thus less extensive damage to some water resource uses. However, hydropower, environmental flow penalty, and agriculture were shown to be sensitive to the change in runoff as well.
C1 [Henderson, James; Jones, Russell; Smith, Joel] Stratus Consulting Inc, Boulder, CO 80306 USA.
[Rodgers, Charles] Asian Dev Bank, Mandaluyong City, Philippines.
[Strzepek, Kenneth] MIT, Cambridge, MA 02139 USA.
[Martinich, Jeremy] US EPA, Climate Change Div, Washington, DC 20460 USA.
RP Henderson, J (reprint author), Stratus Consulting Inc, POB 4059, Boulder, CO 80306 USA.
EM jhenderson@stratusconsulting.com
FU U.S. Environmental Protection Agency's (EPA's) Office of Atmospheric
Programs [EP-W-07-072]
FX We gratefully acknowledge the financial support of the U.S.
Environmental Protection Agency's (EPA's) Office of Atmospheric Programs
(Contract #EP-W-07-072).
NR 43
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Z9 3
U1 2
U2 54
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-2386
EI 1573-1596
J9 MITIG ADAPT STRAT GL
JI Mitig. Adapt. Strateg. Glob. Chang.
PD JAN
PY 2015
VL 20
IS 1
BP 135
EP 157
DI 10.1007/s11027-013-9483-x
PG 23
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AW6WK
UT WOS:000346406000007
ER
PT J
AU Erickson, DJ
Sulzberger, B
Zepp, RG
Austin, AT
AF Erickson, David J., III
Sulzberger, Barbara
Zepp, Richard G.
Austin, Amy T.
TI Effects of stratospheric ozone depletion, solar UV radiation, and
climate change on biogeochemical cycling: interactions and feedbacks
SO PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
LA English
DT Review
ID DISSOLVED ORGANIC-MATTER; PLANT LITTER DECOMPOSITION; CARBON-DIOXIDE
UPTAKE; ARCTIC SEA-ICE; MARINE-PHYTOPLANKTON; OCEAN ACIDIFICATION;
GREENHOUSE GASES; ATMOSPHERIC CO2; TIPPING POINTS; SURFACE WATERS
AB Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment include: (i) enhanced UV-induced mineralisation of above ground litter due to aridification; (ii) enhanced UV-induced mineralisation of photoreactive dissolved organic matter (DOM) in aquatic ecosystems due to changes in continental runoff and ice melting; (iii) reduced efficiency of the biological pump due to UV-induced bleaching of coloured dissolved organic matter (CDOM) in stratified aquatic ecosystems, where CDOM protects phytoplankton from the damaging solar UV-B radiation. Mineralisation of organic matter results in the production and release of CO2, whereas the biological pump is the main biological process for CO2 removal by aquatic ecosystems. This paper also assesses the interactive effects of solar UV radiation and climate change on the biogeochemical cycling of aerosols and trace gases other than CO2, as well as of chemical and biological contaminants. Interacting effects of solar UV radiation and climate change on biogeochemical cycles are particularly pronounced at terrestrial-aquatic interfaces.
C1 [Erickson, David J., III] Oak Ridge Natl Lab, Comp Earth Sci Grp, Div Math & Comp Sci, Oak Ridge, TN 37831 USA.
[Sulzberger, Barbara] Eawag Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland.
[Zepp, Richard G.] US EPA, Athens, GA 30605 USA.
[Austin, Amy T.] Univ Buenos Aires, Inst Invest Fisiol & Ecol Vinculadas Agr IFEVA, Buenos Aires, DF, Argentina.
[Austin, Amy T.] Univ Buenos Aires, CONICET, Buenos Aires, DF, Argentina.
RP Erickson, DJ (reprint author), Oak Ridge Natl Lab, Comp Earth Sci Grp, Div Math & Comp Sci, POB 2008,MS 6016, Oak Ridge, TN 37831 USA.
EM d.j.erickson@tds.net
OI Austin, Amy/0000-0002-7468-5861
FU U.S. Global Change Research Program; Oak Ridge National Laboratory;
Office of Science of the U.S. Department of Energy [DE-AC05-00OR22725];
Eawag: Swiss Federal Institute of Aquatic Science and Technology;
National Exposure Research Laboratory, Ecosystems Research Division,
U.S. Environmental Protection Agency; National Agency of Science and
Technology of Argentina (ANPCyT)
FX D. E. was supported by the U.S. Global Change Research Program and by
the Oak Ridge National Laboratory, which is supported by the Office of
Science of the U.S. Department of Energy under Contract Number
DE-AC05-00OR22725. B. S. was supported by Eawag: Swiss Federal Institute
of Aquatic Science and Technology. R. Z. was supported by the National
Exposure Research Laboratory, Ecosystems Research Division, U.S.
Environmental Protection Agency, and A. A. was supported by grants from
the National Agency of Science and Technology of Argentina (ANPCyT).
NR 251
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U1 12
U2 93
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1474-905X
EI 1474-9092
J9 PHOTOCH PHOTOBIO SCI
JI Photochem. Photobiol. Sci.
PY 2015
VL 14
IS 1
BP 127
EP 148
DI 10.1039/c4pp90036g
PG 22
WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Physical
SC Biochemistry & Molecular Biology; Biophysics; Chemistry
GA AW9HC
UT WOS:000346567000008
PM 25380348
ER
PT J
AU Ghimire, SR
Johnston, JM
AF Ghimire, Santosh R.
Johnston, John M.
BE Karvazy, K
Webster, VL
TI Traditional Knowledge of Rainwater Harvesting Compared to Five Modern
Case Studies
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
ID CLIMATE-CHANGE; WATER; SYSTEM; NEPAL
AB The water-energy-food nexus is receiving increased attention worldwide due to climate change and rising population. According to a projection of the United Nations, the global population is expected to increase by a factor of 1.3 by 2050- from 7.2 billion to 9.6-billion with corresponding demands for energy and food. Climate in the future is predicted to be warmer, with more frequent and intense rainfall as well as decreased rainfall reliability for agriculture in water-stressed regions. Rainwater harvesting (RWH) has been used to meet water demands for millennia. The historical context of RWH is still meaningful today and provides a more informed use of RWH as a climate change adaptation strategy. Our objective is to trace the development of RWH by comparing long-term use of hitis (water-spouts) in Nepal to five modern case studies from the U.S. in NY, FL, TX, IL, and CA.
C1 [Ghimire, Santosh R.] US EPA, ORISE, Off Res & Dev Ecosyst Res Div, Postdoctoral Res Participant, 960 Coll Stn Rd, Athens, GA 30605 USA.
[Johnston, John M.] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30605 USA.
RP Ghimire, SR (reprint author), US EPA, ORISE, Off Res & Dev Ecosyst Res Div, Postdoctoral Res Participant, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM Ghimire.Santosh@epa.gov; Johnston.JohnM@epa.gov
NR 51
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Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 182
EP 193
PG 12
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300017
ER
PT J
AU Shilling, F
Khan, A
Juricich, R
Fong, V
Hodge, D
AF Shilling, Fraser
Khan, Abdul
Juricich, Rich
Fong, Vance
Hodge, Don
BE Karvazy, K
Webster, VL
TI Water Sustainability Indicators for California Water Management
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB The Department of Water Resources (DWR) recognizes the importance of long-term sustainability of the state's water systems. As part of the California Water Plan Update 2013, DWR collaboratively developed an analytical framework to quantify water resources sustainability indicators for California. The California Water Sustainability Indicators Framework brings together water sustainability indicators that will inform us about water system conditions and their relationships to ecosystems, social systems, and economic systems. The framework is a comprehensive system for measuring and reporting water sustainability at watershed, regional, and state scales, relative to quantified sustainability targets. An online tool was developed to contain an encyclopedia of over 1,800 sustainability indicators, as well as the results of the use of a select set of indicators at watershed, regional, and state scales as part of Water Plan Update 2013. The Framework is intended to support reporting of indicators to a wide array of water and environmental stakeholders, the public, and decision makers to build knowledge and to enhance adaptive decision making and policy change.
C1 [Shilling, Fraser] Univ Calif Davis, Environm Sci & Policy, Davis, CA 95616 USA.
[Khan, Abdul; Juricich, Rich] CA Dept Water Resources, Sacramento, CA 94236 USA.
[Fong, Vance] US EPA, Environm Indicator Program, San Francisco, CA 94105 USA.
[Hodge, Don] US EPA Reg, Agr Program, San Francisco, CA 94105 USA.
RP Shilling, F (reprint author), Univ Calif Davis, Environm Sci & Policy, Davis, CA 95616 USA.
EM fmshilling@ucdavis.edu; abdul.khan@water.ca.gov;
rich.juricich@water.ca.gov; Fong.Vance@EPA.Gov; hodge.don@epa.gov
NR 4
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 2341
EP 2349
PG 9
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300230
ER
PT J
AU Sherman, LS
Blum, JD
Dvonch, JT
Gratz, LE
Landis, MS
AF Sherman, Laura S.
Blum, Joel D.
Dvonch, J. Timothy
Gratz, Lynne E.
Landis, Matthew S.
TI The use of Pb, Sr, and Hg isotopes in Great Lakes precipitation as a
tool for pollution source attribution
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Heavy metals; Stable isotopes; Source attribution; Multivariate
statistical receptor modeling; Wet deposition
ID MERCURY WET DEPOSITION; FIRED POWER-PLANTS; MASS-INDEPENDENT
FRACTIONATION; NORTHEASTERN UNITED-STATES; ATMOSPHERIC HEAVY-METALS;
CHICAGO/GARY URBAN AREA; MONTANE FOREST SOILS; STRONTIUM ISOTOPES; LEAD
ISOTOPES; WEATHERING RATES
AB The anthropogenic emission and subsequent deposition of heavy metals including mercury (Hg) and lead (Pb) present human health and environmental concerns. Although it is known that local and regional sources of these metals contribute to deposition in the Great Lakes region, it is difficult to trace emissions from point sources to ithpacted sites. Recent studies suggest that metal isotope ratios may be useful for distinguishing between and tracing source emissions. We measured Pb, strontium (Sr), and Hg isotope ratios in daily precipitation samples that were collected at seven sites across the Great Lakes region between 2003 and 2007. Lead isotope ratios ((207)pb/(206)pb = 0.8062 to 0.8554) suggest that Pb deposition was influenced by coal combustion and processing of Mississippi Valley-Type Pb ore deposits. Regional differences in Sr isotope ratios (Sr-87/Sr-86 = 0.70859 to 0.71155) are likely related to coal fly ash and soil dust. Mercury isotope ratios (delta Hg-202 = -1.13 to 0.13%.) also varied among the sites, likely due to regional differences in coal isotopic composition, and fractionation occurring within industrial facilities and in the atmosphere. These data represent the first combined characterization of Pb, Sr, and Hg isotope ratios in precipitation collected across the Great Lakes region. We demonstrate the utility of multiple metal isotope ratios in parallel with traditional trace element multivariate statistical modeling to enable more complete pollution source attribution. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sherman, Laura S.; Blum, Joel D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA.
[Dvonch, J. Timothy] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
[Gratz, Lynne E.] Univ Washington, Bothell, WA 98011 USA.
[Landis, Matthew S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
RP Sherman, LS (reprint author), Univ Michigan, Dept Earth & Environm Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA.
EM lsaylors@umich.edu
RI Landis, Matthew/P-5149-2014; Dvonch, Joseph/K-3632-2013
OI Landis, Matthew/0000-0002-8742-496X;
FU University of Michigan Water Center of the Graham Sustainability
Institute; University of Michigan [EPD05005]; Fred A. and Barbara M. Erb
Family Foundation; EPA through its Office of Research and Development
[R-82971601]
FX This work was supported in part by the University of Michigan Water
Center of the Graham Sustainability Institute, which receives funds from
the Fred A. and Barbara M. Erb Family Foundation and the University of
Michigan. The EPA through its Office of Research and Development
partially funded and participated in this research through cooperative
agreement R-82971601 and contract EPD05005 with the University of
Michigan. The views expressed in this manuscript are those of the
authors and do not necessarily reflect the views or policies of the EPA.
It has been subjected to Agency review and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use. The authors are grateful to Jamie
Gleason, Marcus Johnson, and Ted Huston for analytical assistance as
well as Jim Barres, Frank Marsik, Emily White, Ali Kamal, Naima Hall,
and Bian Liu for their dedicated efforts in data collection and
interpretation. We also thank four anonymous reviewers for comments that
improved this manuscript. Finally, this research would not have been
possible without the oversight, vision, and commitment of the late Jerry
Keeler.
NR 130
TC 15
Z9 19
U1 11
U2 124
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD JAN 1
PY 2015
VL 502
BP 362
EP 374
DI 10.1016/j.scitotenv.2014.09.034
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU6RZ
UT WOS:000345730800039
PM 25265397
ER
PT J
AU Jauss, V
Johnson, M
Krull, E
Daub, M
Lehmann, J
AF Jauss, Verena
Johnson, Mark
Krull, Evelyn
Daub, Markus
Lehmann, Johannes
TI Pyrogenic carbon controls across a soil catena in the Pacific Northwest
SO CATENA
LA English
DT Article
DE Climate change; Fire; Pyrogenic carbon; Soil development; Soil organic
matter
ID SCOTS PINE FORESTS; BLACK CARBON; ORGANIC-CARBON; FIRE REGIMES; CLIMATE;
VEGETATION; OXIDATION; MOBILITY; CHARCOAL
AB Since turnover times of pyrogenic carbon (PyC) are substantially slower than those of other organic carbon input to soil, it is considered an important constituent of the global C cycle acting as a C sink. In the Pacific Northwest vegetation fires regularly produce PyC, but its accumulation in soils is poorly quantified. Using mid-infrared spectroscopy (MIR) and partial least-squares (PLS) analysis in conjunction with ultraviolet photo-oxidation followed by nuclear magnetic resonance spectroscopy (UV-NMR) techniques, PyC contents were quantified for samples from soil profiles along a vegetation gradient. Sample locations included different forest types as well as sites under agricultural use. While PyC was most prevalent in the first 0.2 m with 7-24% of total soil organic C (SOC), it could be found in the subsoil of all locations. However, PyC concentrations did not change consistently with soil depth. Stock sizes were lowest at the Turkey Farm (0.71 kg m(-2); 10% of SOC) and Organic Growers Farm (1.14 kg m(-2); 8% of SOC) sites, presumably due to the pervasive combustion of grass and cereals. Among the forested sites, lower stocks were observed at sites with higher mean annual temperature (MAT) and lower mean annual precipitation (MAP) such as Metolius (1.71 kg m(-2); 15% of SOC) and Juniper (1.89 kg m(-2); 26% of SOC). In contrast, the highest PyC stocks were found under cooler and moister conditions at Cascade Head dominated by Douglas Fir (Pseudotsuga menziesii (Mirb.)) (5.66 kg m(-2); 16% of SOC) and Soapgrass Mountain (4.80 kg m(-2); 15% of SOC). PyC was only moderately related to non-PyC SOC, which comprises plant residues, their decomposition products and soil biota (r(2) = 0.61 and 0.44 for SOC with and without PyC, respectively), suggesting largely independent processes influencing production and disappearance. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jauss, Verena; Lehmann, Johannes] Cornell Univ, Dept Crop & Soil Sci, Ithaca, NY 14853 USA.
[Johnson, Mark] Environm Protect Agcy, Western Ecol Div, Corvallis, OR 97333 USA.
[Krull, Evelyn] CSIRO Land & Water, Glen Osmond, SA 5064, Australia.
[Daub, Markus] Univ Stuttgart, Inst Anal Dynam & Modelling, D-70569 Stuttgart, Germany.
[Lehmann, Johannes] Cornell Univ, Atkinson Ctr Sustainable Future, Ithaca, NY 14853 USA.
RP Lehmann, J (reprint author), Cornell Univ, 909 Bradfield Hall, Ithaca, NY 14853 USA.
EM CL273@cornell.edu
FU NASA-USDA [2008-35615-18961]; Department of Crop and Soil Sciences at
Cornell University
FX Funding through NASA-USDA award No. 2008-35615-18961 and the Department
of Crop and Soil Sciences at Cornell University is gratefully
acknowledged. For help with fieldwork we would like to thank Sarah Hash
(Department of Crop and Soil Science, Oregon State University). Many
thanks to L.R. Spouncer and Jon Sanderman for help with MIR analyses and
data processing. We thank the anonymous referees for their constructive
comments.
NR 38
TC 5
Z9 5
U1 1
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0341-8162
EI 1872-6887
J9 CATENA
JI Catena
PD JAN
PY 2015
VL 124
BP 53
EP 59
DI 10.1016/j.catena.2014.09.001
PG 7
WC Geosciences, Multidisciplinary; Soil Science; Water Resources
SC Geology; Agriculture; Water Resources
GA AU3WJ
UT WOS:000345541200006
ER
PT J
AU Williams, WC
Copeland, C
Boykin, E
Quell, SJ
Lehmann, DM
AF Williams, W. C.
Copeland, C.
Boykin, E.
Quell, S. J.
Lehmann, D. M.
TI Development and utilization of an ex vivo bromodeoxyuridine local lymph
node assay protocol for assessing potential chemical sensitizers
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Article
DE Local lymph node assay; 5-bromo-2-deoxyuridine (BrdU); skin
sensitization; ex vivo; platinum
ID INTER-LABORATORY VALIDATION; ISOTOPIC END-POINT; ICCVAM EVALUATION;
MAXIMIZATION TEST; PLATINUM; POTENCY; ALLERGENS; PERFORMANCE; BRDU; LLNA
AB The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. Exposure to a dermal sensitizer results in proliferation of local lymph node T cells, which has traditionally been measured by in vivo incorporation of [H-3]methyl thymidine. A more recent non-isotopic variation of the assay utilizes bromodeoxyuridine (BrdU) incorporation in vivo. To further improve the utility of this assay, we developed an ex vivo BrdU labeling procedure eliminating the need for in vivo injections. The results of this assay correctly identified a strong sensitizer (i.e., trimellitic anhydride) as well as weak/moderate sensitizers (i.e., eugenol, cinnamaldehyde and hexylcinnaminic aldehyde). As anticipated, neither non-sensitizers isopropanol and lactic acid nor the false negative chemical nickel II sulfate hexahydrate induced a positive threshold response in the assay. The results of this assay are in close agreement with those of the in vivo LLNA:BrdU-enzyme-linked immunosorbent assay labeling procedure. We also used the ex vivo BrdU LLNA procedure to evaluate ammonium hexachloroplatinate, ammonium tetrachloroplatinate and cis-diamminedichloroplatinum(II) and the assay correctly identified them as sensitizers based on the calculation of EC2 values. We conclude that this ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. We developed an ex vivo BrdU-labeling procedure eliminating the need for in vivo injections. The ex vivo BrdU LLNA accurately predicted the sensitization potential of known sensitizers and non-sensitizers. This ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope.
C1 [Williams, W. C.; Copeland, C.; Boykin, E.; Lehmann, D. M.] US EPA, NHEERL, EPHD, Cardiopulm & Immunotoxicol Branch, Res Triangle Pk, NC 27711 USA.
RP Lehmann, DM (reprint author), US EPA, NHEERL, EPHD, Cardiopulm & Immunotoxicol Branch, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lehmann.david@epa.gov
NR 44
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
EI 1099-1263
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD JAN
PY 2015
VL 35
IS 1
BP 29
EP 40
DI 10.1002/jat.2983
PG 12
WC Toxicology
SC Toxicology
GA AU4GD
UT WOS:000345567300004
PM 24532485
ER
PT J
AU Thai, SF
Wallace, KA
Jones, CP
Ren, HZ
Prasad, RY
Ward, WO
Kohan, MJ
Blackman, CF
AF Thai, Sheau-Fung
Wallace, Kathleen A.
Jones, Carlton P.
Ren, Hongzu
Prasad, Raju Y.
Ward, William O.
Kohan, Michael J.
Blackman, Carl F.
TI Signaling Pathways and MicroRNA Changes in Nano-TiO2 Treated Human Lung
Epithelial (BEAS-2B) Cells
SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
LA English
DT Article
DE Nanomaterial; Nano-Titanium Dioxide; mRNA Expression Profiling;
Signaling Pathways; MicroRNA Profiling; IPA MicroRNA Target Filter
Analysis
ID TITANIUM-DIOXIDE NANOPARTICLES; GROWTH-FACTOR; CANCER CELLS; MIR-17-92
CLUSTER; OXIDATIVE STRESS; THROMBOSPONDIN-1 EXPRESSION;
PROGNOSTIC-SIGNIFICANCE; CLINICAL-SIGNIFICANCE; PROGENITOR CELLS;
DNA-DAMAGE
AB The effect of titanium dioxide nanoparticles (nano-TiO2 Degussa p25) treatment of human lung epithelial cells (BEAS-2B) was examined by analyzing changes in messenger [mRNA] and microRNA [miRNA]. BEAS-2B cells were treated with 0, 3, 10, 30 or 100 mu g/ml nano-TiO2 for 1 day (for mRNA analysis) or 3 days (for miRNA analysis). Differentially expressed mRNA and miRNA were analyzed using Affymetrix microarrays and Affymetrix miRNA microarrays, respectively. Although, the tested doses were not cytotoxic, there were alterations in both mRNA and miRNA expression. The expression of mRNA/miRNA changes were examined in MetaCore (GeneGo) and IPA (Ingenuity Pathway Analysis) to delineate associated canonical/signaling pathways. Canonical/signaling pathways altered by nano-TiO2 treatments included: cell cycle regulation, apoptosis, calcium signaling, translation, NRF2 mediated oxidative response, IGF1 signaling, RAS signaling, PI3K/AKT signaling, cytoskeleton remodeling, cell adhesion, BMP signaling, and inflammatory response. Many of the genes in these pathways are known to be regulated by the miRNAs whose expressions were altered by the nano-TiO2 treatment. The miRNA 17-92 cluster and let-7 miRNA family that are involved in lung cancer formation were altered by nano-TiO2 treatment. The miR-17-92 cluster, an oncogenic microRNA cluster, is induced while the tumor suppressor microRNA, let-7 family, is suppressed. The changes of let-7/KRAS signaling pathway was observed in all the doses treated. The observed changes in miRNA expression introduces an additional mechanistic dimension that supports the significance of the observed mRNA expression changes, and demonstrated that the nano-TiO2 in vitro treatment in human lung cells can cause diverse but coordinated pathway alterations associated with changes in in vivo response to tumorigenes.
C1 [Thai, Sheau-Fung; Wallace, Kathleen A.; Jones, Carlton P.; Ren, Hongzu; Prasad, Raju Y.; Ward, William O.; Kohan, Michael J.; Blackman, Carl F.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Thai, SF (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,MD B105-3, Res Triangle Pk, NC 27711 USA.
OI Blackman, Carl/0000-0003-3267-5224
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 102
TC 3
Z9 3
U1 7
U2 38
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1533-4880
EI 1533-4899
J9 J NANOSCI NANOTECHNO
JI J. Nanosci. Nanotechnol.
PD JAN
PY 2015
VL 15
IS 1
BP 492
EP 503
DI 10.1166/jnn.2015.9202
PG 12
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AT6NA
UT WOS:000345054000089
PM 26328389
ER
PT J
AU Pauer, JJ
DePetro, PA
Anstead, AM
Lehrter, JC
AF Pauer, James J.
DePetro, Phillip A.
Anstead, Amy M.
Lehrter, John C.
TI Application of a one-dimensional model to explore the drivers and
lability of carbon in the northern Gulf of Mexico
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Modeling; Nutrients; Hypoxia; Dissolved organic carbon; Light
limitation; Gulf of Mexico
ID DISSOLVED ORGANIC-MATTER; MISSISSIPPI RIVER PLUME; LOUISIANA
CONTINENTAL-SHELF; PHYTOPLANKTON PRODUCTION; COASTAL WATERS; FOOD-WEB;
HYPOXIA; NITROGEN; GROWTH; REGION
AB A one-dimensional water quality model, Gulf of Mexico Dissolved Oxygen Model (GoMDOM-1D), was developed to simulate phytoplankton, carbon, nitrogen and phosphorus in the northern Gulf of Mexico. The model was calibrated and corroborated against a comprehensive set of field observations and process measurements. Model results fit measured nutrients and phytoplankton concentrations well, but the model was unable to sustain dissolved organic carbon and water-column respiration at measured levels. The decline in modeled dissolved organic carbon (DOC) and respiration supports the notion that autochthonous production of DOC was insufficient to offset the respiratory demand from bacterial processes for the most of the Louisiana continental shelf. Transport of carbon from high production areas close to the Mississippi and Atchafalaya River plumes likely supplied a part of the respiratory demand of the water column. Modeling results showed that DOC in the study area on the Louisiana shelf was very labile with the highest lability during the month of June, and decreased lability in April. Primary production at the study sites was mainly nitrogen limited, although phosphorus limitation was found in the surface layers for the areas most impacted by the Mississippi River plume. The model also provided insights into the interplay between nutrients and light in regulating phytoplankton production, which is important when predicting the location and extent of hypoxia in the Gulf of Mexico. Published by Elsevier B.V.
C1 [Pauer, James J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[DePetro, Phillip A.] ICF Int, Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Lehrter, John C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Pauer, JJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM pauer.james@epa.gov
NR 60
TC 2
Z9 2
U1 2
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
EI 1872-7026
J9 ECOL MODEL
JI Ecol. Model.
PD DEC 24
PY 2014
VL 294
BP 59
EP 70
DI 10.1016/j.ecolmodel.2014.09.007
PG 12
WC Ecology
SC Environmental Sciences & Ecology
GA AU8BG
UT WOS:000345821100007
ER
PT J
AU McConnell, ER
Bell, SM
Cote, I
Wang, RL
Perkins, EJ
Garcia-Reyero, N
Gong, P
Burgoon, LD
AF McConnell, Emma R.
Bell, Shannon M.
Cote, Ila
Wang, Rong-Lin
Perkins, Edward J.
Garcia-Reyero, Natalia
Gong, Ping
Burgoon, Lyle D.
TI Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment
SO PLOS ONE
LA English
DT Review
ID GENE-EXPRESSION; CIGARETTE-SMOKE; DIESEL EXHAUST; TRANSCRIPTOME; TCDD;
MICROARRAY; EXPOSURE; CELLS
AB Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues to adopt new molecular and systems biology technologies. Systematic screening reviews can help risk assessors and assessment teams determine which studies to consider for inclusion in a human health assessment. A tool for systematic reviews should be standardized and transparent in order to consistently determine which studies meet minimum quality criteria prior to performing in-depth analyses of the data. The Systematic Omics Analysis Review (SOAR) tool is focused on assisting risk assessment support teams in performing systematic reviews of transcriptomic studies. SOAR is a spreadsheet tool of 35 objective questions developed by domain experts, focused on transcriptomic microarray studies, and including four main topics: test system, test substance, experimental design, and microarray data. The tool will be used as a guide to identify studies that meet basic published quality criteria, such as those defined by the Minimum Information About a Microarray Experiment standard and the Toxicological Data Reliability Assessment Tool. Seven scientists were recruited to test the tool by using it to independently rate 15 published manuscripts that study chemical exposures with microarrays. Using their feedback, questions were weighted based on importance of the information and a suitability cutoff was set for each of the four topic sections. The final validation resulted in 100% agreement between the users on four separate manuscripts, showing that the SOAR tool may be used to facilitate the standardized and transparent screening of microarray literature for environmental human health risk assessment.
C1 [McConnell, Emma R.; Bell, Shannon M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Cote, Ila] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Arlington, VA USA.
[Wang, Rong-Lin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH USA.
[Perkins, Edward J.] US Army, Corps Engineers, Dept Army, Dept Def, Vicksburg, MS 39180 USA.
[Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem & Biochem, Jackson, MS USA.
[Gong, Ping] SpecPro Inc, Vicksburg, MS USA.
[Burgoon, Lyle D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Burgoon, LD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Burgoon.Lyle@epa.gov
OI Burgoon, Lyle/0000-0003-4977-5352
FU US EPA's Human Health Risk Assessment Program; SpecPro, Inc
FX This work was funded by the US EPA's Human Health Risk Assessment
Program. The funders had no role in study design, or data collection and
analysis. EPA management cleared the manuscript for publication, which
included helpful suggestions that improved the overall quality of the
manuscript, consistent with the US EPA Scientific Integrity Policy.
Co-author Ping Gong is employed by SpecPro, Inc. SpecPro, Inc provided
support in the form of salary for author PG, but did not have any
additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The specific role
of this author is articulated in the 'author contributions' section.
NR 29
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U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 22
PY 2014
VL 9
IS 12
AR UNSP e110379
DI 10.1371/journal.pone.0110379
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA3ZY
UT WOS:000348845100002
PM 25531884
ER
PT J
AU Brantley, HL
Thoma, ED
Squier, WC
Guven, BB
Lyon, D
AF Brantley, Halley L.
Thoma, Eben D.
Squier, William C.
Guven, Birnur B.
Lyon, David
TI Assessment of Methane Emissions from Oil and Gas Production Pads using
Mobile Measurements
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NATURAL-GAS
AB A new mobile methane emissions inspection approach, Other Test Method (OTM) 33A, was used to quantify short-term emission rates from 210 oil and gas production pads during eight two-week field studies in Texas, Colorado, and Wyoming from 2010 to 2013. Emission rates were log-normally distributed with geometric means and 95% confidence intervals (CIs) of 0.33 (0.23, 0.48), 0.14 (0.11, 0.19), and 0.59 (0.47, 0.74) g/s in the Barnett, Denver-Julesburg, and Pinedale basins, respectively. This study focused on sites with emission rates above 0.01 g/s and included short-term (i.e., condensate tank flashing) and maintenance-related emissions. The results fell within the upper ranges of the distributions observed in recent onsite direct measurement studies. Considering data across all basins, a multivariate linear regression was used to assess the relationship of methane emissions to well age, gas production, and hydrocarbon liquids (oil or condensate) production. Methane emissions were positively correlated with gas production, but only approximately 10% of the variation in emission rates was explained by variation in production levels. The weak correlation between emission and production rates may indicate that maintenance-related stochastic variables and design of production and control equipment are factors determining emissions.
C1 [Brantley, Halley L.; Thoma, Eben D.; Squier, William C.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Guven, Birnur B.] Houston Adv Res Ctr, The Woodlands, TX 77381 USA.
[Lyon, David] Environm Def Fund, Austin, TX 78701 USA.
RP Thoma, ED (reprint author), US EPA, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM thoma.eben@epa.gov
FU U.S. EPA ORD's Air, Climate, and Energy (ACE); Regional Applied Research
Effort (RARE) programs; Fiona and Stan Druckenmiller, Heising-Simons
Foundation; Bill and Susan Oberndorf, Betsy and Sam Reeves, Robertson
Foundation; Alfred P. Sloan Foundation; TomKat Charitable Trust; Walton
Family Foundation
FX We thank Shahrooz Amin and Mark Modrak with ARCADIS, Inc., for field and
data analysis support for this project. We would like to thank EPA
colleagues Bill Mitchell, Adam Eisele, Mike Miller, Jason DeWees, Robin
Segall, and Ken Garing and his team for ongoing support in development
of OTM 33. Special thanks to Eric Crosson, Chris Rella, and Tracy Tsai
with Picarro for ongoing collaboration on mobile measurements. Primary
funding for this effort was provided by U.S. EPA ORD's Air, Climate, and
Energy (ACE) and Regional Applied Research Effort (RARE) programs.
Funding for the Environmental Defense Fund's methane research series,
including this work, is provided for by Fiona and Stan Druckenmiller,
Heising-Simons Foundation, Bill and Susan Oberndorf, Betsy and Sam
Reeves, Robertson Foundation, Alfred P. Sloan Foundation, TomKat
Charitable Trust, and the Walton Family Foundation. The views expressed
in this article are those of the authors and do not necessarily
represent the views or policies of the U.S. Environmental Protection
Agency.
NR 23
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U1 3
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 16
PY 2014
VL 48
IS 24
BP 14508
EP 14515
DI 10.1021/es503070q
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AX1CO
UT WOS:000346686100054
PM 25375308
ER
PT J
AU George, IJ
Hays, MD
Snow, R
Faircloth, J
George, BJ
Long, T
Baldauf, RW
AF George, Ingrid J.
Hays, Michael D.
Snow, Richard
Faircloth, James
George, Barbara J.
Long, Thomas
Baldauf, Richard W.
TI Cold Temperature and Biodiesel Fuel Effects on Speciated Emissions of
Volatile Organic Compounds from Diesel Trucks
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID UNREGULATED EMISSIONS; POLLUTANT EMISSIONS; DRIVING CYCLES; HYDROCARBON
EMISSIONS; PASSENGER CAR; BLENDS; VEHICLE; CARBONYL; PARTICULATE;
GASOLINE
AB Speciated volatile organic compounds (VOCs) were measured in diesel exhaust from three heavy-duty trucks equipped with modern aftertreatment technologies. Emissions testing was conducted on a chassis dynamometer at two ambient temperatures (-7 and 22 degrees C) operating on two fuels (ultra low sulfur diesel and 20% soy biodiesel blend) over three driving cycles: cold start, warm start and heavy-duty urban dynamometer driving cycle. VOCs were measured separately for each drive cycle. Carbonyls such as formaldehyde and acetaldehyde dominated VOC emissions, making up similar to 72% of the sum of the speciated VOC emissions (Sigma VOCs) overall. Biodiesel use led to minor reductions in aromatics and variable changes in carbonyls. Cold temperature and cold start conditions caused dramatic enhancements in VOC emissions, mostly carbonyls, compared to the warmer temperature and other drive cycles, respectively. Different 2007+ aftertreatment technologies involving catalyst regeneration led to significant modifications of VOC emissions that were compound-specific and highly dependent on test conditions. A comparison of this work with emission rates from different diesel engines under various test conditions showed that these newer technologies resulted in lower emission rates of aromatic compounds. However, emissions of other toxic partial combustion products such as carbonyls were not reduced in the modern diesel vehicles tested.
C1 [George, Ingrid J.; Hays, Michael D.; Snow, Richard; Faircloth, James; Long, Thomas; Baldauf, Richard W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[George, Barbara J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Hays, MD (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM hays.michael@epa.gov
RI Hays, Michael/E-6801-2013
OI Hays, Michael/0000-0002-4029-8660
NR 46
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U1 3
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 16
PY 2014
VL 48
IS 24
BP 14782
EP 14789
DI 10.1021/es502949a
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AX1CO
UT WOS:000346686100086
PM 25393130
ER
PT J
AU Hubbell, B
Greenbaum, D
AF Hubbell, Bryan
Greenbaum, Daniel
TI Counterpoint: Moving From Potential-Outcomes Thinking to Doing-Changing
Research Planning to Enable Successful Health Outcomes Research
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE accountability; air pollution; health outcomes; regulations
AB The potential-outcomes framework is an appealing new approach that imposes a degree of formal conceptual modeling beyond traditional epidemiologic methods for assessing associations between air pollution and health. However, it introduces a number of additional factors to consider when selecting intervention and especially control conditions that call for forward-thinking research designs. We propose that researchers seeking to implement the potential-outcomes framework consider the use of prospective designs that provide more opportunities to establish well-defined intervention and control populations and determine causal relationships between air quality and health. In implementing these prospective research designs, collaboration between researchers and those who implement the interventions can improve the understanding of how a planned intervention actually occurs, thereby improving the characterization of emissions and air quality responses to the intervention. By looking ahead, epidemiologists can take advantage of upcoming regulatory interventions to design successful health outcomes research programs.
C1 [Hubbell, Bryan] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Greenbaum, Daniel] Hlth Effects Inst, Boston, MA USA.
RP Hubbell, B (reprint author), US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, MD 504-02, Res Triangle Pk, NC 27711 USA.
EM hubbell.bryan@epa.gov
NR 8
TC 1
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U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD DEC 15
PY 2014
VL 180
IS 12
BP 1141
EP 1144
DI 10.1093/aje/kwu266
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AW6ZN
UT WOS:000346414300002
PM 25399413
ER
PT J
AU Goltz, MN
Huang, JQ
AF Goltz, Mark N.
Huang, Junqi
TI Reply to comment on "Validation of two innovative methods to measure
contaminant mass flux in groundwater" by Goltz et al. (2009)
SO JOURNAL OF CONTAMINANT HYDROLOGY
LA English
DT Editorial Material
DE Groundwater flow; Pump test; Modeling
C1 [Goltz, Mark N.] US Air Force, Inst Technol, ENV, Wright Patterson AFB, OH 45433 USA.
[Huang, Junqi] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74821 USA.
RP Goltz, MN (reprint author), US Air Force, Inst Technol, ENV, 2950 Hobson Way,Bldg 640, Wright Patterson AFB, OH 45433 USA.
EM mark.goltz@afit.edu; huang.junqi@epa.gov
NR 3
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-7722
EI 1873-6009
J9 J CONTAM HYDROL
JI J. Contam. Hydrol.
PD DEC 15
PY 2014
VL 171
BP 83
EP 84
DI 10.1016/j.jconhyd.2014.10.014
PG 2
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA AW6RO
UT WOS:000346396400009
PM 25453250
ER
PT J
AU Ziegler, AD
Sidle, RC
Phang, VXH
Wood, SH
Tantasirin, C
AF Ziegler, Alan D.
Sidle, R. C.
Phang, Valerie X. H.
Wood, Spencer H.
Tantasirin, Chatchai
TI Bedload transport in SE Asian streams-Uncertainties and implications for
reservoir management
SO GEOMORPHOLOGY
LA English
DT Review
DE Bedload-to-sediment ratio; Sediment yield; Road impacts; Mass wasting;
Dam building; Agriculture intensification
ID GRAVEL-BED STREAM; HELLEY-SMITH SAMPLERS; HORTON OVERLAND-FLOW; NORTHERN
THAILAND; SEDIMENT TRANSPORT; EXPERIMENTAL REMOVAL; PENINSULAR MALAYSIA;
MOUNTAIN STREAMS; SOUTHEAST-ASIA; LOAD TRANSPORT
AB This paper reviews the current state of knowledge regarding bedload transport in SE Asian streams and presents the results from a case study on bedload transport in a mountain stream in northern Thailand. Together, the review and new data help contextualize the paucity of work done in the region in the face of a rapid increase in development and reservoir building throughout SE Asia. Data from both the reviewed studies and the case study indicate that bedload transport in many SE Asian streams (e.g. catchment areas < 100 km(2)) is often much higher than is commonly assumed for tropical streams (i.e., about 10% of the total sediment load). Estimated annual bedload proportion was 18% of the total annual sediment load in the 74-km(2) Mae Sa Catchment in northern Thailand. Bedload transport rates ranged from 0.001 to 1.1 kg s(-1); and measured total suspended solid (TSS) rates ranged from 0.01 to 39 kg s(-1), equivalent to TSS concentrations of 20 to 14,000 mg I-1 (associated with flows ranging from 0.4 to 30 m(3) s(-1)). Event and annual loads of bedload and TSS were determined from rating curves based on automated measurements of discharge and turbidity (for TSS only). When taking uncertainty into account, the estimated range for the bedload proportion of total sediment load was 9-25% (equivalent to a yield of 81-279 Mg km(-2)y(-1)). The corresponding TSS yield estimate ranged from 649 to 1037 Mg km(-2); and the total sediment load is an estimated 730-1313 Mg km(-2)y(-1). The proportion of bedload was lower than that reported in some other Asia streams, probably due to the occurrence of extended periods with high TSS that dampened the bedload signal, which was sand-dominated during the low-energy events that were sampled. Nevertheless, the bedload rate was generally higher than for most SE Asian locations, likely due to the occurrence of several road-related landslides the previous year. Although we were not able to measure bedload transport for high energy flows (discharges > 4.5 m(3) s(-1)), we believe our upper estimates for bedload variables (25% of the total sediment load; and a yield of 279 Mg Km(-2) y(-1)) provide reasonable upper bounds. Finally, the bulk of bedload transport is episodic in nature, with a higher proportion moved during high energy tropical storms that occur late in the monsoon rainy season, as well as in response to both natural and anthropogenic landscape disturbances. The possibility that bedload proportion could exceed 20-40% for rivers and streams of various sizes reinforces the need for accurate estimates of both bedload and suspended solid loads prior to building dams in the region. Past examples of reservoir closure following rapid infilling possibly stem from underestimating sediment loads, particularly the bedload component, and failing to factor in the very high sediment loads associated with large storm events. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ziegler, Alan D.; Phang, Valerie X. H.] Natl Univ Singapore, Dept Geog, Singapore 117568, Singapore.
[Sidle, R. C.] US EPA, Ecosyst Res Div, Athens, GA USA.
[Wood, Spencer H.] Boise State Univ, Dept Geol Sci, Boise, ID 83725 USA.
[Tantasirin, Chatchai] Kasetsart Univ, Fac Forestry, Dept Conservat, Bangkok, Thailand.
RP Ziegler, AD (reprint author), Natl Univ Singapore, Dept Geog, 1 Arts Link, Singapore 117568, Singapore.
EM geoadz@nus.edu.sg
FU APN [ARCP2006-07NMY, ARCP2007-01CMY]; SARCS [95/01/CW-005]; NASA
[IDS/0365-0079]; NSF [EAR-0000546]
FX This work was supported in part by grants from the following agencies
APN (ARCP2006-07NMY, ARCP2007-01CMY), SARCS (95/01/CW-005), NASA
(IDS/0365-0079), NSF (EAR-0000546). Special thanks is given to our
colleagues Jefferson M Fox, Thomas W. Giambelluca, and Mike A Nullet,
who were instrumental in the establishment of monitoring network at Mae
Sa. We also thank R.J. Wasson for comments on the manuscript. This
document has been reviewed in accordance with the U.S. Environmental
Protection Agency policy and approved for publication. Mention of trade
names or commercial products does not constitute an endorsement or
recommendation for use.
NR 141
TC 6
Z9 6
U1 3
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-555X
EI 1872-695X
J9 GEOMORPHOLOGY
JI Geomorphology
PD DEC 15
PY 2014
VL 227
SI SI
BP 31
EP 48
DI 10.1016/j.geomorph.2014.01.015
PG 18
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA AR5KP
UT WOS:000343624000004
ER
PT J
AU Jagai, JS
Smith, GS
Schmid, JE
Wade, TJ
AF Jagai, Jyotsna S.
Smith, Genee S.
Schmid, Judith E.
Wade, Timothy J.
TI Trends in gastroenteritis-associated mortality in the United States,
1985-2005: variations by ICD-9 and ICD-10 codes
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Gastroenteritis; Mortality; Intestinal infections
ID INCREASING ANTIBIOTIC-RESISTANCE; CLOSTRIDIUM-DIFFICILE; DISEASES;
DEATHS; AGENTS; CARE
AB Background: Trends in gastroenteritis-associated mortality are changing over time with development of antibiotic resistant strains of certain pathogens, improved diagnostic methods, and changing healthcare. In 1999, ICD-10 coding was introduced for mortality records which can also affect trends. We assess trends in gastroenteritis-associated mortality and changes associated with coding.
Methods: Trends in gastroenteritis-associated mortality rates in the United States were examined using the National Center for Health Statistics Multiple Cause-of-Death Mortality databases for 1985-2005. All deaths with the underlying cause or any contributing cause included gastroenteritis were included. Cases were selected based on ICD9 (pre-1999) and ICD10 (1999-2005) codes and all analyses were stratified by ICD usage. Annual trends in age adjusted mortality rates were assessed using linear regression spline analysis. Relative risks and 95% confidence intervals (CIs) were calculated using Poisson regression adjusted for age group, sex, race, and region.
Results: There were a total of 190,674 deaths related to gastroenteritis in the U.S. from 1985-2005 with an average of 9,080 per year. During this time the percent of deaths related to gastroenteritis more than tripled, increasing from 0.25% to 0.80% of all deaths. Though the time periods varied in length, we demonstrate a significant increase in slope from a 0.0054% annual increase during the period 1985-1998, when ICD-9 coding was used, to a 0.0550% annual increase during 1999-2005, when ICD-10 coding was used. For both time periods, the oldest age group (75+ years) demonstrated the highest risk of death due to gastroenteritis. Additionally, males demonstrated higher risk than females and blacks were at higher risk than whites for death due to gastroenteritis.
Conclusions: This analysis demonstrates the public health burden of gastroenteritis-associated mortality in the United States and changes in trends due to change from ICD-9 to ICD-10 coding. The overall rate of gastroenteritis-associated mortality has more than tripled over the 21-year period from 1985 to 2005 and the primary burden of deaths due to gastroenteritis is in the elderly population.
C1 [Jagai, Jyotsna S.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL 60625 USA.
[Smith, Genee S.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Schmid, Judith E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Cores Unit, Res Triangle Pk, NC 27711 USA.
[Jagai, Jyotsna S.; Wade, Timothy J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div,Epidemiol Branch, Res Triangle Pk, NC 27711 USA.
RP Jagai, JS (reprint author), Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL 60625 USA.
EM jjagai2@uic.edu
NR 25
TC 2
Z9 2
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD DEC 10
PY 2014
VL 14
AR 211
DI 10.1186/s12876-014-0211-0
PG 8
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AX2AF
UT WOS:000346744800002
PM 25492520
ER
PT J
AU Baig, RBN
Varma, RS
AF Baig, R. B. Nasir
Varma, Rajender S.
TI Magnetic Silica-Supported Palladium Catalyst: Synthesis of Allyl Aryl
Ethers in Water
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID RECYCLABLE CATALYST; ORGANIC-SYNTHESIS; EFFICIENT; ALCOHOLS;
ETHERIFICATION; NANOPARTICLES; ARYLATION; COMPLEX
AB A simple and benign procedure for the synthesis of aryl allyl ethers has been developed using phenols, allyl acetates, and magnetically recyclable silica-supported palladium catalyst in water; the performance of the reaction in air and easy separation of the catalyst using an external magnet are sustainable attributes of the reaction.
C1 [Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@.epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory
FX R.B.N.B. was supported by the Postgraduate Research Program at the
National Risk Management Research Laboratory, administered by the Oak
Ridge Institute for Science and Education, through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 38
TC 12
Z9 12
U1 3
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD DEC 10
PY 2014
VL 53
IS 49
BP 18625
EP 18629
DI 10.1021/ie501081q
PG 5
WC Engineering, Chemical
SC Engineering
GA AW5NR
UT WOS:000346322200004
ER
PT J
AU Wang, RL
Bencic, DC
Garcia-Reyero, N
Perkins, EJ
Villeneuve, DL
Ankley, GT
Biales, AD
AF Wang, Rong-Lin
Bencic, David C.
Garcia-Reyero, Natalia
Perkins, Edward J.
Villeneuve, Daniel L.
Ankley, Gerald T.
Biales, Adam D.
TI Natural Variation in Fish Transcriptomes: Comparative Analysis of the
Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio)
SO PLOS ONE
LA English
DT Article
ID GENE-EXPRESSION SIGNATURES; NOISE; CONSEQUENCES; MECHANISMS; PLATFORMS;
MOLECULES; EVOLUTION; VARIANCE; PROFILES; PATTERNS
AB Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, better characterization and understanding are needed for natural variation in gene expression among fish individuals from lab cultures. Leveraging the transcriptomics data from a number of our toxicogenomics studies conducted over the years, we conducted a meta-analysis of nearly 600 microarrays generated from the ovary tissue of untreated, reproductively mature fathead minnow and zebrafish samples. As expected, there was considerable batch-to-batch transcriptomic variation; this "batch-effect'' appeared to differentially impact subsets of fish transcriptomes in a nonsystematic way. Temporally more closely spaced batches tended to share a greater transcriptomic similarity among one another. The overall level of within-batch variation was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects. The observed differences in the within-batch variability of gene expression, at the levels of both individual genes and pathways, were probably both technical and biological. This suggests that biological interpretation and prioritization of genes and pathways targeted by experimental conditions should take into account both their intrinsic variability and the size of induced transcriptional changes. There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish. The high degree of conservation offers promising opportunities in not only studying fish molecular responses to environmental stressors by a comparative biology approach, but also effective sharing of a large amount of existing public transcriptomics data for developing toxicogenomics applications.
C1 [Wang, Rong-Lin; Bencic, David C.; Biales, Adam D.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Perkins, Edward J.] US Army Corps Engn, US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Wang, Rong-Lin; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
RP Wang, RL (reprint author), US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
EM wang.rong-lin@epa.gov
FU U.S. EPA; U.S. Army [BAA 11-4838]
FX Funding was provided by U.S. EPA and U.S. Army (grant BAA 11-4838). The
manuscript has been approved for publication by U.S. EPA and U.S. Army
Corps Chief of Engineers. The funders had no role in study design, data
collection and analysis, or preparation of the manuscript.
NR 56
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U1 3
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 10
PY 2014
VL 9
IS 12
AR e114178
DI 10.1371/journal.pone.0114178
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AW9YP
UT WOS:000346611400034
PM 25493933
ER
PT J
AU Tufts, JAM
Meyer, KM
Calfee, MW
Lee, SD
AF Tufts, Jenia A. M.
Meyer, Kathryn M.
Calfee, Michael Worth
Lee, Sang Don
TI Composite Sampling of a Bacillus anthracis Surrogate with Cellulose
Sponge Surface Samplers from a Nonporous Surface
SO PLOS ONE
LA English
DT Article
ID FOODBORNE PATHOGENS; STAINLESS-STEEL; SPORES; SURVIVAL
AB A series of experiments was conducted to explore the utility of composite-based collection of surface samples for the detection of a Bacillus anthracis surrogate using cellulose sponge samplers on a nonporous stainless steel surface. Two composite-based collection approaches were evaluated over a surface area of 3716 cm(2) (four separate 929 cm(2) areas), larger than the 645 cm(2) prescribed by the standard Centers for Disease Control (CDC) and Prevention cellulose sponge sampling protocol for use on nonporous surfaces. The CDC method was also compared to a modified protocol where only one surface of the sponge sampler was used for each of the four areas composited. Differences in collection efficiency compared to positive controls and the potential for contaminant transfer for each protocol were assessed. The impact of the loss of wetting buffer from the sponge sampler onto additional surface areas sampled was evaluated. Statistical tests of the results using ANOVA indicate that the collection of composite samples using the modified sampling protocol is comparable to the collection of composite samples using the standard CDC protocol (p = 0.261). Most of the surface-bound spores are collected on the first sampling pass, suggesting that multiple passes with the sponge sampler over the same surface may be unnecessary. The effect of moisture loss from the sponge sampler on collection efficiency was not significant (p = 0.720) for both methods. Contaminant transfer occurs with both sampling protocols, but the magnitude of transfer is significantly greater when using the standard protocol than when the modified protocol is used (p<0.001). The results of this study suggest that composite surface sampling, by either method presented here, could successfully be used to increase the surface area sampled per sponge sampler, resulting in reduced sampling times in the field and decreased laboratory processing cost and turn-around times.
C1 [Tufts, Jenia A. M.; Meyer, Kathryn M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Tufts, Jenia A. M.; Meyer, Kathryn M.; Calfee, Michael Worth; Lee, Sang Don] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Calfee, MW (reprint author), US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM calfee.worth@epa.gov
FU US EPA through an Interagency Agreement; US Department of Energy's ORISE
program; US EPA; ORISE
FX This work was funded by the US EPA through an Interagency Agreement with
the US Department of Energy's ORISE program. Authors MWC and SDL
received salary funds from the US EPA; JAT and KM received fellowship
stipends through ORISE.
NR 15
TC 3
Z9 3
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 3
PY 2014
VL 9
IS 12
AR e114082
DI 10.1371/journal.pone.0114082
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA7WS
UT WOS:000349128700068
PM 25470365
ER
PT J
AU Wang, HH
Ho, KT
Scheckel, KG
Wu, FC
Cantwell, MG
Katz, DR
Horowitz, DB
Boothman, WS
Burgess, RM
AF Wang, Huanhua
Ho, Kay T.
Scheckel, Kirk G.
Wu, Fengchang
Cantwell, Mark G.
Katz, David R.
Horowitz, Doranne Borsay
Boothman, Warren S.
Burgess, Robert M.
TI Toxicity, Bioaccumulation, and Biotransformation of Silver Nanoparticles
in Marine Organisms
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ACID-VOLATILE SULFIDE; ENVIRONMENTAL TRANSFORMATIONS; ENGINEERED
NANOMATERIALS; NEREIS-DIVERSICOLOR; SEDIMENTS; POLYCHAETE; IMPACT;
BIOAVAILABILITY; FATE; AGGREGATION
AB The toxicity, bioaccumulation, and biotransformation of citrate and polyvinylpyrrolidone (PVP) coated silver nanoparticles (NPs) (AgNP-citrate and AgNP-PVP) in marine organisms via marine sediment exposure was investigated. Results from 7-d sediment toxicity tests indicate that AgNP-citrate and AgNP-PVP did not exhibit toxicity to the amphipod (Ampelisca abdita) and mysid (Americamysis bahia) at <= 75 mg/kg dry wt. A 28-d bioaccumulation study showed that Ag was significantly accumulated in the marine polychaete Nereis virens (N. virens) in the AgNP-citrate, AgNP-PVP and a conventional salt (AgNO3) treatments. Synchrotron X-ray absorption spectroscopy (XAS) results showed the distribution of Ag species in marine sediments amended with AgNP-citrate, AgNP-PVP, and AgNO3 was AgCl (50-65%) > Ag2S (32-42%) > Ag metal (Ag-0) (3-11%). In N virens, AgCl (25-59%) and Ag2S (10-31%) generally decreased and, Ag metal (32-44%) increased, relative to the sediments. The patterns of speciation in the worm were different depending upon the coating of the AgNP and both types of AgNPs were different than the AgNO3 salt. These results show that the AgNP surface capping agents influenced Ag uptake, biotransformation, and/or excretion. To our knowledge, this is the first demonstration of the bioaccumulation and speciation of AgNPs in a marine organism (N. virens).
C1 [Wang, Huanhua; Ho, Kay T.; Cantwell, Mark G.; Katz, David R.; Horowitz, Doranne Borsay; Boothman, Warren S.; Burgess, Robert M.] US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Wang, Huanhua; Wu, Fengchang] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China.
[Scheckel, Kirk G.] US EPA, ORD, NRMRL, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA.
RP Ho, KT (reprint author), US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM ho.kay@epa.gov; wufengchang@vip.skleg.cn
RI ID, MRCAT/G-7586-2011;
OI Scheckel, Kirk/0000-0001-9326-9241
FU U.S. EPA as a National Research Council postdoctoral research associate;
DOE Office of Science by Argonne National Laboratory
[DE-AC02-06CH11357]; US Department of Energy - Basic Energy Sciences;
NSERC; University of Washington; Canadian Light Source; Advanced Photon
Source; U.S. DOE [DE-AC02-06CH11357]
FX H. Wang was supported by the U.S. EPA as a National Research Council
postdoctoral research associate. The authors wish to thank Drs. Todd
Luxton, Walter Berry, and Shibin Li of the USEPA for their insightful
reviews of this manuscript. This research used resources of the Advanced
Photon Source, a U.S. Department of Energy (DOE) Office of Science User
Facility operated for the DOE Office of Science by Argonne National
Laboratory under Contract No. DE-AC02-06CH11357. Sector 20 facilities at
the Advanced Photon Source, and research at these facilities, are
supported by the US Department of Energy - Basic Energy Sciences, a
Major Resources Support grant from NSERC, the University of Washington,
the Canadian Light Source, and the Advanced Photon Source. Use of the
Advanced Photon Source, an Office of Science User Facility operated for
the U.S. Department of Energy Office of Science by Argonne National
Laboratory, was supported by the U.S. DOE under Contract No.
DE-AC02-06CH11357. The authors wish to thank Dr. Dale L. Brewe and Dr.
Robert Gordon for assistance in X-ray absorption spectroscopy and X-ray
fluorescence mapping at beamline 20-ID-B,C of PNC/XSD facilities. This
research has been subject to U.S. EPA peer review; however, it does not
necessarily reflect the views of the Agency. Mention of trade names of
commercial products and companies does not constitute endorsement or
recommendation for use. This is ORD # 007579.
NR 30
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U1 10
U2 94
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 2
PY 2014
VL 48
IS 23
BP 13711
EP 13717
DI 10.1021/es502976y
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AU7TN
UT WOS:000345803800019
PM 25369427
ER
PT J
AU Whitehouse, PJ
Sykes, K
George, DR
AF Whitehouse, Peter J.
Sykes, Kathy
George, Daniel R.
TI Ecological Change and Aging: A Need to Think Deeply and Act Quickly
SO INTERNATIONAL JOURNAL OF AGING & HUMAN DEVELOPMENT
LA English
DT Editorial Material
C1 [Whitehouse, Peter J.] Case Western Reserve Univ, Shaker Hts, OH 44122 USA.
[Sykes, Kathy] US EPA, Washington, DC 20460 USA.
[George, Daniel R.] Penn State Coll Med, Hershey, PA USA.
RP Whitehouse, PJ (reprint author), Case Western Reserve Univ, 2895 Carlton Rd, Shaker Hts, OH 44122 USA.
EM peter.whitehouse@case.edu
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-4150
EI 1541-3535
J9 INT J AGING HUM DEV
JI Int. J. Aging Human Dev.
PD DEC
PY 2014
VL 80
IS 1
SI SI
BP 3
EP 9
DI 10.1177/0091415015591106
PG 7
WC Gerontology; Psychology, Developmental
SC Geriatrics & Gerontology; Psychology
GA CP2QR
UT WOS:000359722600001
PM 26215295
ER
PT J
AU Goh, V
Yap, HM
Gutierrez, RA
Ng, LC
Vesper, SS
AF Goh, V
Yap, H. M.
Gutierrez, R. A.
Ng, L. C.
Vesper, S. S.
TI DNA-Based Analyses of Molds in Singapore Public Buildings Results in a
Proposed Singapore Environmental Relative Moldiness Index
SO TROPICAL BIOMEDICINE
LA English
DT Article
ID ASPERGILLUS
AB Dust samples (n=75) were collected from shopping malls, hotels and libraries in Singapore and then analyzed using Mold Specific Quantitative Polymerase Chain Reaction (MSQPCR) for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI). Most of these molds (23/36) occur at similar rates in Singapore and the United States. A Singapore Environmental Relative Moldiness Index (SERMI) is proposed which might be divided into low (<18), medium (18 to 28) and high (>28) mold burden categories but more samples will help to refine these categories.
C1 [Goh, V; Yap, H. M.; Gutierrez, R. A.; Ng, L. C.] Natl Environm Agcy, Environm Hlth Inst, Singapore 138667, Singapore.
[Vesper, S. S.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Ng, LC (reprint author), Natl Environm Agcy, Environm Hlth Inst, 11 Biopolis Way,06-05-08 Helios Block, Singapore 138667, Singapore.
EM ng_lee_ching@nea.gov.sg
FU Ministry of Environment and Water Resources (MEWR), Environmental
Innovation Funds [EIF 038]
FX This research was supported by the Ministry of Environment and Water
Resources (MEWR), Environmental Innovation Funds (EIF 038). We would
like to thank the shopping malls, libraries and hotels, which have
kindly agreed to participate in this study. The National Environment
Agency of Singapore would also like to express their heartfelt thanks to
Dr Stephen Vesper, Environmental Protection Agency, United States, for
his dedicated collaboration and guidance in the project.
NR 15
TC 1
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U1 2
U2 2
PU MALAYSIAN SOC PARASITOLOGY TROPICAL MEDICINE
PI KUALA LUMPUR
PA C/O INST MEDICAL REEARCH, JALAN PAHANG, KUALA LUMPUR, 50588, MALAYSIA
SN 0127-5720
J9 TROP BIOMED
JI Trop. Biomed.
PD DEC
PY 2014
VL 31
IS 4
BP 663
EP 669
PG 7
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA CB6CJ
UT WOS:000349714200010
PM 25776591
ER
PT J
AU Varma, RS
AF Varma, Rajender S.
TI Greener and Sustainable Chemistry
SO APPLIED SCIENCES-BASEL
LA English
DT Editorial Material
ID ASSISTED ORGANIC-SYNTHESIS; BENIGN REACTION MEDIA; SUPPORTED REAGENTS;
MICROWAVE; NANOPARTICLES; CATALYSTS
C1 US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
NR 25
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U1 3
U2 27
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD DEC
PY 2014
VL 4
IS 4
BP 493
EP 497
DI 10.3390/app4040493
PG 5
WC Chemistry, Multidisciplinary; Materials Science, Multidisciplinary;
Physics, Applied
SC Chemistry; Materials Science; Physics
GA CA3ZP
UT WOS:000348844200002
ER
PT J
AU Villeneuve, DL
Crump, D
Garcia-Reyero, N
Hecker, M
Hutchinson, TH
LaLone, CA
Landesmann, B
Lettieri, T
Munn, S
Nepelska, M
Ottinger, MA
Vergauwen, L
Whelan, M
AF Villeneuve, Daniel L.
Crump, Doug
Garcia-Reyero, Natalia
Hecker, Markus
Hutchinson, Thomas H.
LaLone, Carlie A.
Landesmann, Brigitte
Lettieri, Teresa
Munn, Sharon
Nepelska, Malgorzata
Ottinger, Mary Ann
Vergauwen, Lucia
Whelan, Maurice
TI Adverse Outcome Pathway (AOP) Development I: Strategies and Principles
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE adverse outcome pathway; regulatory toxicology; predictive toxicology;
extrapolation; knowledgebase
ID DISRUPTING CHEMICALS; CONCEPTUAL-FRAMEWORK; RISK-ASSESSMENT; IPCS
FRAMEWORK; MODE; IDENTIFICATION; PRIORITIZATION; RELEVANCE; HUMANS
AB An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regulatory decision-making through greater integration and more meaningful use of mechanistic data. However, for the scientific community to collectively develop a useful AOP knowledgebase that encompasses toxicological contexts of concern to human health and ecological risk assessment, it is critical that AOPs be developed in accordance with a consistent set of core principles. Based on the experiences and scientific discourse among a group of AOP practitioners, we propose a set of five fundamental principles that guide AOP development: (1) AOPs are not chemical specific; (2) AOPs are modular and composed of reusable components-notably key events (KEs) and key event relationships (KERs); (3) an individual AOP, composed of a single sequence of KEs and KERs, is a pragmatic unit of AOP development and evaluation; (4) networks composed of multiple AOPs that share common KEs and KERs are likely to be the functional unit of prediction for most real-world scenarios; and (5) AOPs are living documents that will evolve over time as new knowledge is generated. The goal of the present article was to introduce some strategies for AOP development and detail the rationale behind these 5 key principles. Consideration of these principles addresses many of the current uncertainties regarding the AOP framework and its application and is intended to foster greater consistency in AOP development.
C1 [Villeneuve, Daniel L.; LaLone, Carlie A.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Crump, Doug] Environm Canada, Ecotoxicol & Wildlife Hlth Div, Ottawa, ON K1A 0H3, Canada.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA.
[Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada.
[Hecker, Markus] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada.
[Hutchinson, Thomas H.] Univ Plymouth, Sch Biol Sci, Plymouth PL4 8AA, Devon, England.
[LaLone, Carlie A.] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA.
[Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Whelan, Maurice] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, Italy.
[Ottinger, Mary Ann] Univ Houston, Dept Biol & Biochem, Houston, TX 77004 USA.
[Vergauwen, Lucia] Univ Antwerp, Dept Vet Sci, Zebrafishlab, B-2610 Antwerp, Belgium.
RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM villeneuve.dan@epa.gov
OI Vergauwen, Lucia/0000-0002-6534-7473
NR 25
TC 47
Z9 49
U1 10
U2 74
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 312
EP 320
DI 10.1093/toxsci/kfu199
PG 9
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800001
PM 25466378
ER
PT J
AU Villeneuve, DL
Crump, D
Garcia-Reyero, N
Hecker, M
Hutchinson, TH
LaLone, CA
Landesmann, B
Lettieri, T
Munn, S
Nepelska, M
Ottinger, MA
Vergauwen, L
Whelan, M
AF Villeneuve, Daniel L.
Crump, Doug
Garcia-Reyero, Natalia
Hecker, Markus
Hutchinson, Thomas H.
LaLone, Carlie A.
Landesmann, Brigitte
Lettieri, Teresa
Munn, Sharon
Nepelska, Malgorzata
Ottinger, Mary Ann
Vergauwen, Lucia
Whelan, Maurice
TI Adverse Outcome Pathway Development II: Best Practices
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE adverse outcome pathway; regulatory toxicology; predictive toxicology;
extrapolation; knowledgebase
ID GROWTH PROMOTER 17-BETA-TRENBOLONE; ENDOCRINE DISRUPTION;
RISK-ASSESSMENT; IPCS FRAMEWORK; TOXICITY; CONSERVATION; TARGETS; MODE;
21ST-CENTURY; REACTIVITY
AB Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of "functional equivalence" can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach.
C1 [Villeneuve, Daniel L.; LaLone, Carlie A.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Crump, Doug] Environm Canada, Ecotoxicol & Wildlife Hlth Div, Ottawa, ON K1A 0H3, Canada.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA.
[Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada.
[Hecker, Markus] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada.
[Hutchinson, Thomas H.] Univ Plymouth, Sch Biol Sci, Plymouth PL4 8AA, Devon, England.
[LaLone, Carlie A.] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA.
[Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Whelan, Maurice] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, Italy.
[Ottinger, Mary Ann] Univ Houston, Dept Biol & Biochem, Houston, TX 77004 USA.
[Vergauwen, Lucia] Univ Antwerp, Dept Vet Sci, Zebrafishlab, B-2610 Antwerp, Belgium.
RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, 201 Congdon Blvd, Duluth, MN 55804 USA.
EM villeneuve.dan@epa.gov
OI Vergauwen, Lucia/0000-0002-6534-7473
NR 27
TC 38
Z9 39
U1 6
U2 43
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 321
EP 330
DI 10.1093/toxsci/kfu200
PG 10
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800002
PM 25466379
ER
PT J
AU Snow, SJ
McGee, J
Miller, DB
Bass, V
Schladweiler, MC
Thomas, RF
Krantz, T
King, C
Ledbetter, AD
Richards, J
Weinstein, JP
Conner, T
Willis, R
Linak, WP
Nash, D
Wood, CE
Elmore, SA
Morrison, JP
Johnson, CL
Gilmour, MI
Kodavanti, UP
AF Snow, Samantha J.
McGee, John
Miller, Desinia B.
Bass, Virginia
Schladweiler, Mette C.
Thomas, Ronald F.
Krantz, Todd
King, Charly
Ledbetter, Allen D.
Richards, Judy
Weinstein, Jason P.
Conner, Teri
Willis, Robert
Linak, William P.
Nash, David
Wood, Charles E.
Elmore, Susan A.
Morrison, James P.
Johnson, Crystal L.
Gilmour, Matthew Ian
Kodavanti, Urmila P.
TI Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel
Additive Induce Adverse Pulmonary and Systemic Effects
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE diesel exhaust; cerium oxide; cardiopulmonary; nanoparticle
ID SPRAGUE-DAWLEY RATS; OXIDATIVE STRESS; EXHAUST INHALATION; INTRATRACHEAL
INSTILLATION; PARTICULATE MATTER; PERIPHERAL-BLOOD; IMMUNE-RESPONSES;
EXPOSURE; PARTICLES; CELLS
AB Diesel exhaust (DE) exposure induces adverse cardiopulmonary effects. Cerium oxide nanoparticles added to diesel fuel (DECe) increases fuel burning efficiency but leads to altered emission characteristics and potentially altered health effects. Here, we evaluated whether DECe results in greater adverse pulmonary effects compared with DE. Male Sprague Dawley rats were exposed to filtered air, DE, or DECe for 5 h/day for 2 days. N-acetyl glucosaminidase activity was increased in bronchial alveolar lavage fluid (BALF) of rats exposed to DECe but not DE. There were also marginal but insignificant increases in several other lung injury biomarkers in both exposure groups (DECe>DE for all). To further characterize DECe toxicity, rats in a second study were exposed to filtered air or DECe for 5 h/day for 2 days or 4 weeks. Tissue analysis indicated a concentration-and time-dependent accumulation of lung and liver cerium followed by a delayed clearance. The gas-phase and high concentration of DECe increased lung inflammation at the 2-day time point, indicating that gas-phase components, in addition to particles, contribute to pulmonary toxicity. This effect was reduced at 4 weeks except for a sustained increase in BALF gamma-glutamyl transferase activity. Histopathology and transmission electron microscopy revealed increased alveolar septa thickness due to edema and increased numbers of pigmented macrophages after DECe exposure. Collectively, these findings indicate that DECe induces more adverse pulmonary effects on a mass basis than DE. In addition, lung accumulation of cerium, systemic translocation to the liver, and delayed clearance are added concerns to existing health effects of DECe.
C1 [Snow, Samantha J.; Miller, Desinia B.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Snow, Samantha J.; McGee, John; Schladweiler, Mette C.; Thomas, Ronald F.; Krantz, Todd; King, Charly; Ledbetter, Allen D.; Richards, Judy; Gilmour, Matthew Ian; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Bass, Virginia] Univ N Carolina, Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Weinstein, Jason P.; Conner, Teri; Willis, Robert] US EPA, Environm Characterizat & Apportionment Branch, NERL, Res Triangle Pk, NC 27711 USA.
[Linak, William P.; Nash, David] US EPA, Air Pollut Prevent & Control Div, NRMRL, Res Triangle Pk, NC 27711 USA.
[Nash, David] Arcadis US Inc, Durham, NC 27713 USA.
[Wood, Charles E.] US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Elmore, Susan A.] Natl Inst Environm Hlth Sci, Natl Toxicol Program Div, Res Triangle Pk, NC 27711 USA.
[Morrison, James P.; Johnson, Crystal L.] Pathol Associates Inc, Charles River Labs, Durham, NC 27703 USA.
RP Snow, SJ (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM snow.samantha@epa.gov
OI Bass, Virginia/0000-0001-6219-2448; Snow, Samantha/0000-0003-1812-8582
FU U.S. Environmental Protection Agency/University of North Carolina
Toxicology [CR835152010]; U.S. Environmental Protection Agency Senior
Environmental Employment Program; Division of the National Toxicology
Program of the National Institutes of Health
FX This work was supported by the U.S. Environmental Protection
Agency/University of North Carolina Toxicology Training Agreement
CR835152010 to S.J.S.; U.S. Environmental Protection Agency Senior
Environmental Employment Program to R.F.T.; and the Division of the
National Toxicology Program of the National Institutes of Health.
NR 66
TC 7
Z9 8
U1 2
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 403
EP 417
DI 10.1093/toxsci/kfu187
PG 15
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800010
PM 25239632
ER
PT J
AU Dishaw, LV
Hunter, DL
Padnos, B
Padilla, S
Stapleton, HM
AF Dishaw, Laura V.
Hunter, Deborah L.
Padnos, Beth
Padilla, Stephanie
Stapleton, Heather M.
TI Developmental Exposure to Organophosphate Flame Retardants Elicits Overt
Toxicity and Alters Behavior in Early Life Stage Zebrafish (Danio rerio)
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE flame retardant; organophosphate; TDCPP; zebrafish; development;
neurotoxicity
ID LARVAL ZEBRAFISH; HORMONE-LEVELS; HOUSE-DUST; IN-VIVO; TDCPP;
CHLORPYRIFOS; NEUROTOXICITY; METABOLITES; PHOSPHATE;
ACETYLCHOLINESTERASE
AB Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs are structurally similar to organophosphate pesticides and may adversely affect the developing nervous system. This study evaluated the overt toxicity, uptake, and neurobehavioral effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCPP), and tris (2,3-dibromopropyl) phosphate (TDBPP) in early life stage zebrafish. Chlorpyrifos was used as a positive control. For overt toxicity and neurobehavioral assessments, zebrafish were exposed from 0 to 5 days postfertilization (dpf). Hatching, death, or malformations were evaluated daily. Teratogenic effects were scored by visual examination on 6 dpf. To evaluate uptake and metabolism, zebrafish were exposed to 1 mu M of each organophosphate (OP) flame retardant and collected on 1 and 5 dpf to monitor accumulation. Larval swimming activity was measured in 6 dpf larvae to evaluate neurobehavioral effects of exposures below the acute toxicity threshold. TDBPP elicited the greatest toxicity at >1 mu M. TDCPP and chlorpyrifos were overtly toxic at concentrations >= 10 mu M, TCEP, and TCPP were not overtly toxic at the doses tested. Tissue concentrations increased with increasing hydrophobicity of the parent chemical after 24h exposures. TDCPP and TDBPP and their respective metabolites were detected in embryos on 5 dpf. For all chemicals tested, developmental exposures that were not overtly toxic significantly altered larval swimming activity. These data indicate that OPFRs adversely affect development of early life stage zebrafish.
C1 [Dishaw, Laura V.; Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
[Hunter, Deborah L.; Padnos, Beth; Padilla, Stephanie] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Stapleton, HM (reprint author), Duke Univ, Nicholas Sch Environm, Box 90328,LSRC A220, Durham, NC 27708 USA.
EM heather.stapleton@duke.edu
FU National Institute of Environmental Health Sciences [R01 ES016099]; US
Environmental Protection Agency STAR Fellowship [FP 91728801]
FX This study was supported by the National Institute of Environmental
Health Sciences [R01 ES016099] and the US Environmental Protection
Agency STAR Fellowship [FP 91728801].
NR 43
TC 24
Z9 25
U1 17
U2 127
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 445
EP 454
DI 10.1093/toxsci/kfu194
PG 10
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800014
PM 25239634
ER
PT J
AU Wu, WD
Muller, R
Berhane, K
Fruin, S
Liu, FF
Jaspers, I
Diaz-Sanchez, D
Peden, DB
McConnell, R
AF Wu, Weidong
Muller, Robin
Berhane, Kiros
Fruin, Scott
Liu, Feifei
Jaspers, Ilona
Diaz-Sanchez, David
Peden, David B.
McConnell, Rob
TI Inflammatory Response of Monocytes to Ambient Particles Varies by
Highway Proximity
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE traffic-related air pollution; oxidative stress; inflammation; exposure
assessment; epidemiology
ID AIRBORNE PARTICULATE MATTER; OXIDATIVE STRESS; AIR-POLLUTION;
CHEMICAL-COMPOSITION; HOSPITAL ADMISSIONS; EPITHELIAL-CELLS; DAILY
MORTALITY; DIFFERENT SITES; LUNG INJURY; UTAH VALLEY
AB Epidemiological studies have demonstrated associations of chronic respiratory disease with near-roadway pollutant exposure, effects that were independent of those of regional air pollutants. However, there has been limited study of the potential mechanisms for near roadway effects. Therefore, we examined the in vitro effect of respirable particulate matter (PM) collected adjacent to a major Los Angeles freeway and at an urban background location. PM was collected on filters during two consecutive 15-day periods. Oxidative stress and inflammatory response (intracellular reactive oxygen species [ROS], IL-1 beta, IL-6, IL-8, and TNF-alpha) to PM aqueous extract was assessed in THP-1 cells, a model for evaluating monocyte/macrophage lineage cell responses. The near-roadway PM induced statistically significantly higher levels of IL-6, IL-8, and TNF-alpha (P < 0.01) and a near significant increase in IL-1 beta (P = 0.06) but did not induce ROS activity (P = 0.17). The contrast between urban background and near-roadway PM-induced inflammatory cytokines was similar in magnitude to that corresponding to temporal differences between the two collection periods. PM-induced proinflammatory protein expression was attenuated by antioxidant pretreatment, and PM stimulation enhanced the activity of protein kinases, including extracellular signal-regulated kinase and c-Jun N-terminal kinase. Pretreatment of THP-1 cells with kinase inhibitors reduced PM-induced proinflammatory mediator expression. The proinflammatory response was also reduced by pretreatment with polymyxin B, suggesting a role for endotoxin. However, the patterns of PM-induced protein kinase response and the attenuation of inflammatory responses by antioxidant or polymyxin B pretreatment did not vary between near-roadway and urban background locations. We conclude that near-roadway PM produced greater inflammatory response than urban background PM, a finding consistent with emerging epidemiologic findings, but these differences were not explained by PM endotoxin content or by MAPK pathways. Nevertheless, THP-1 cells may be a model for the development of biologically relevant metrics of long-term spatial variation in exposure for study of chronic disease.
C1 [Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan Province, Peoples R China.
[Wu, Weidong; Muller, Robin; Jaspers, Ilona; Peden, David B.] Univ N Carolina, Sch Med, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Berhane, Kiros; Fruin, Scott; Liu, Feifei; McConnell, Rob] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
[Diaz-Sanchez, David] US EPA, Off Res & Dev, Washington, DC 20460 USA.
RP McConnell, R (reprint author), Univ So Calif, Keck Sch Med, 2001 N Soto St, Los Angeles, CA 90089 USA.
EM rmcconne@usc.edu
FU National Institutes of Health [P30ES007048, P01ES011627, P01ES022845,
R01 ES016535, T32 ES007126, K25ES019224, U19AI077437]; Environmental
Protection Agency [CR 83346301, RD83544101, R831845]; Hastings
Foundation
FX This work was supported by National Institutes of Health grants
P30ES007048, P01ES011627, P01ES022845, R01 ES016535, T32 ES007126,
K25ES019224, and U19AI077437; by Environmental Protection Agency grants
CR 83346301, RD83544101, and R831845; and by the Hastings Foundation.
NR 43
TC 8
Z9 8
U1 1
U2 13
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD DEC
PY 2014
VL 51
IS 6
BP 802
EP 809
DI 10.1165/rcmb.2013-0265OC
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KS
UT WOS:000347419700009
PM 24895888
ER
PT J
AU Martinu, T
Gowdy, KM
Nugent, JL
Sun, J
Kinnier, CV
Nelson, ME
Lyes, MA
Kelly, FL
Foster, WM
Gunn, MD
Palmer, SM
AF Martinu, Tereza
Gowdy, Kymberly M.
Nugent, Julia L.
Sun, Jesse
Kinnier, Christine V.
Nelson, Margaret E.
Lyes, Matthew A.
Kelly, Francine L.
Foster, W. Michael
Gunn, Michael D.
Palmer, Scott M.
TI Role of C-C Motif Ligand 2 and C-C Motif Receptor 2 in Murine Pulmonary
Graft-versus-Host Disease after Lipopolysaccharide Inhalations
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE graft-versus-host disease; lipopolysaccharide; dendritic cells; C-C
motif ligand 2; C-C motif receptor 2
ID CHEMOATTRACTANT PROTEIN-1 MCP-1; IDIOPATHIC PNEUMONIA SYNDROME;
STEM-CELL TRANSPLANTATION; INNATE IMMUNE ACTIVATION; DENDRITIC CELLS;
LUNG INJURY; AIRWAY HYPERRESPONSIVENESS; INHALED LIPOPOLYSACCHARIDE;
CHEMOKINE RECEPTOR-2; CCR2(-/-) MICE
AB Environmental exposures are a potential trigger of chronic pulmonary graft-versus-host disease (pGVHD) after successful recovery from hematopoietic cell transplant (HCT). We hypothesized that inhalations of LPS, a prototypic environmental stimulus, trigger pGVHD via increased pulmonary recruitment of donor-derived antigen-presenting cells (APCs) through the C-C motif ligand 2 (CCL2)-C-C motif receptor 2 (CCR2) chemokine axis. B10.BR(H2(k)) and C57BL/6(H2(b)) mice underwent allogeneic (Allo) or syngeneic (Syn) HCT with wild-type (WT) C57BL/6, CCL2(-/-), or CCR2(-/-) donors. After 4 weeks, recipient mice received daily inhaled LPS for 5 days and were killed at multiple time points. Allo mice exposed to repeated inhaled LPS developed prominent lymphocytic bronchiolitis, similar to human pGVHD. The increase in pulmonary T cells in Allo mice after LPS exposures was accompanied by increased CCL2, CCR2, and Type-1 T-helper cytokines as well as by monocytes and monocytederived dendritic cells (moDCs) compared with Syn and nontransplanted controls. Using CCL2(-/-) donors leads to a significant decrease in lungDCs but to only mildly reduced CD4 T cells. Using CCR2(-/-) donors significantly reduces lung DCs and moDCs but does not change T cells. CCL2 or CCR2 deficiency does not alter pGVHD pathology but increases airway hyperreactivity and IL-5 or IL-13 cytokines. Our results show that hematopoietic donor- derived CCL2 and CCR2 regulate recruitment of APCs to the Allo lung after LPS exposure. Although they do not alter pathologic pGVHD, their absence is associated with increased airway hyperreactivity and IL-5 and IL-13 cytokines. These results suggest that the APC changes that result from CCL2-CCR2 blockade may have unexpected effects on T cell differentiation and physiologic outcomes in HCT.
C1 [Martinu, Tereza; Nelson, Margaret E.; Lyes, Matthew A.; Kelly, Francine L.; Foster, W. Michael; Gunn, Michael D.; Palmer, Scott M.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Palmer, Scott M.] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA.
[Gowdy, Kymberly M.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Nugent, Julia L.; Sun, Jesse] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
[Kinnier, Christine V.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
RP Martinu, T (reprint author), Duke Univ, Med Ctr, DUMC Box 3221, Durham, NC 27710 USA.
EM tereza.martinu@duke.edu
FU National Institutes of Health [S10RR019145]
FX The authors thank Mr. Robert F. Beasley for help with lung DC isolation.
Flow cytometric sorting was performed in the Duke Human Vaccine
Institute Research Flow Cytometry Shared Resource Facility (Durham, NC)
supported by National Institutes of Health grant S10RR019145.
NR 36
TC 1
Z9 1
U1 0
U2 3
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD DEC
PY 2014
VL 51
IS 6
BP 810
EP 821
DI 10.1165/rcmb.2013-0451OC
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KS
UT WOS:000347419700010
PM 24921973
ER
PT J
AU Filer, D
Patisaul, HB
Schug, T
Reif, D
Thayer, K
AF Filer, Dayne
Patisaul, Heather B.
Schug, Thaddeus
Reif, David
Thayer, Kristina
TI Test driving ToxCast: endocrine profiling for 1858 chemicals included in
phase II
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID PROTECTION
AB Identifying chemicals, beyond those already implicated, to test for potential endocrine disruption is a challenge and high throughput approaches have emerged as a potential tool for this type of screening. This review focused the Environmental Protection Agency's (EPA) ToxCast (TM) high throughput in vitro screening (HTS) program. Utility for identifying compounds was assessed and reviewed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through the ToxPi (TM) prioritization scheme for endocrine disruption. The analysis included metabolic and neuroendocrine targets. This investigative approach simultaneously assessed the utility of ToxCast, and helped identify novel chemicals which may have endocrine activity. Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
C1 [Filer, Dayne] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Patisaul, Heather B.] N Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA.
[Schug, Thaddeus] NIEHS, Div Extramural Res, NIH, Dept Hlth & Human Serv, Morrisville, NC 27560 USA.
[Reif, David] N Carolina State Univ, Bioinformat Res Ctr, Dept Biol Sci, Raleigh, NC 27695 USA.
[Thayer, Kristina] NIEHS, Off Hlth Assessment & Translat, Div Natl Toxicol Program, NIH,Dept Hlth & Human Serv, Morrisville, NC 27560 USA.
RP Thayer, K (reprint author), NIEHS, Off Hlth Assessment & Translat, Div Natl Toxicol Program, NIH,Dept Hlth & Human Serv, 530 Davis Dr,Room 2150 Mail Drop K2-04, Morrisville, NC 27560 USA.
EM thayer@niehs.nih.gov
OI Reif, David/0000-0001-7815-6767
FU Intramural NIH HHS [ZIA ES103226-01]
NR 16
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Z9 13
U1 2
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2014
VL 19
BP 145
EP 152
DI 10.1016/j.coph.2014.09.021
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AY3UO
UT WOS:000347508000023
PM 25460227
ER
PT J
AU Zhang, Q
Bhattacharya, S
Conolly, RB
Clewell, HJ
Kaminski, NE
Andersen, ME
AF Zhang, Qiang
Bhattacharya, Sudin
Conolly, Rory B.
Clewell, Harvey J., III
Kaminski, Norbert E.
Andersen, Melvin E.
TI Molecular Signaling Network Motifs Provide a Mechanistic Basis for
Cellular Threshold Responses
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID ENVIRONMENTAL CONTAMINANT 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN;
TRANSCRIPTION FACTOR NFAT1; ROBUST PERFECT ADAPTATION; INTEGRAL
FEEDBACK-CONTROL; LOW-DOSE EXTRAPOLATION; HEAT-SHOCK FACTOR;
RISK-ASSESSMENT; GENE-EXPRESSION; CHEMICAL CARCINOGENESIS; BIOCHEMICAL
SYSTEMS
AB Background: Increasingly, there is a move toward using in vitro toxicity testing to assess human health risk due to chemical exposure. As with in vivo toxicity testing, an important question for in vitro results is whether there are thresholds for adverse cellular responses. Empirical evaluations may show consistency with thresholds, but the main evidence has to come from mechanistic considerations.
Objectives: Cellular response behaviors depend on the molecular pathway and circuitry in the cell and the manner in which chemicals perturb these circuits. Understanding circuit structures that are inherently capable of resisting small perturbations and producing threshold responses is an important step towards mechanistically interpreting in vitro testing data.
Methods: Here we have examined dose-response characteristics for several biochemical network motifs. These network motifs are basic building blocks of molecular circuits underpinning a variety of cellular functions, including adaptation, homeostasis, proliferation, differentiation, and apoptosis. For each motif, we present biological examples and models to illustrate how thresholds arise from specific network structures.
Discussion and Conclusion: Integral feedback, feedforward, and transcritical bifurcation motifs can generate thresholds. Other motifs (e. g., proportional feedback and ultrasensitivity) produce responses where the slope in the low-dose region is small and stays close to the baseline. Feedforward control may lead to nonmonotonic or hormetic responses. We conclude that network motifs provide a basis for understanding thresholds for cellular responses. Computational pathway modeling of these motifs and their combinations occurring in molecular signaling networks will be a key element in new risk assessment approaches based on in vitro cellular assays.
C1 [Zhang, Qiang; Bhattacharya, Sudin; Clewell, Harvey J., III; Andersen, Melvin E.] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC 27709 USA.
[Conolly, Rory B.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Durham, NC USA.
[Kaminski, Norbert E.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
[Kaminski, Norbert E.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
RP Zhang, Q (reprint author), Hamner Inst Hlth Sci, Ctr Dose Response Modeling, Inst Chem Safety Sci, 6 Davis Dr, Res Triangle Pk, NC 27709 USA.
EM qzhang@thehamner.org
FU National Institute of Environmental Health Sciences (NIEHS) [P42ES04911]
FX The National Institute of Environmental Health Sciences (NIEHS)
Superfund Research Program at Michigan State University (P42ES04911)
provided support for the Computational Core at The Hamner Institutes to
model research results from the program itself and also to generate
better mechanistic understanding of the behavior of basic network motifs
involved in generating and maintaining biological functions in cellular
systems. [Short courses of computational systems biology pathway
modeling have been developed by the Computational Core; course
materials, including lectures, modeling tutorials, and computational
models are available online (http://www. thehamner.
org/about-the-hamner/education-training/ dose-response-modeling).] Key
sponsors of computational systems biology pathway modeling of the Hamner
programs over the past decade include the ExxonMobil Foundation, Dow
Chemical Foundation, Unilever, Dow Corning Chemical Corporation, and the
American Chemistry Council Long-Range Research Initiative.
NR 104
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Z9 18
U1 3
U2 28
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2014
VL 122
IS 12
BP 1261
EP 1270
DI 10.1289/ehp.1408244
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YC
UT WOS:000347384600011
PM 25117432
ER
PT J
AU Quiros-Alcala, L
Mehta, S
Eskenazi, B
AF Quiros-Alcala, Lesliam
Mehta, Suril
Eskenazi, Brenda
TI Pyrethroid Pesticide Exposure and Parental Report of Learning Disability
and Attention Deficit/Hyperactivity Disorder in US Children: NHANES
1999-2002
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID URINARY METABOLITES; PERMETHRIN EXPOSURE; INSECTICIDES; RATS;
DELTAMETHRIN; MICE; NEUROTOXICITY; CYPERMETHRIN; ASSOCIATION; POPULATION
AB BACKGROUND: Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited.
OBJECTIVE: We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) and attention deficit/hyperactivity disorder (ADHD) in children 6-15 years of age.
METHODS: Using logistic regression, we estimated associations of urinary metabolites of pyrethroid insecticides with parent-reported LD, ADHD, and both LD and ADHD in 1,659-1,680 children participating in the National Health and Nutrition Examination Survey (1999-2002).
RESULTS: The prevalence rates of parent-reported LD, ADHD, and both LD and ADHD were 12.7%, 10.0%, and 5.4%, respectively. Metabolite detection frequencies for 3-PBA [3-phenoxybenzoic acid], cis-DCCA [cis-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid], and trans-DCCA [trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid] were 77.1%, 35.6%, and 33.9%, respectively. The geometric mean 3-PBA concentration was 0.32 mu g/L (median = 0.31 mu g/L; interquartile rage = 0.10-0.89 mu g/L). cis- and trans-DCCA 75th-percentile concentrations were 0.21 mu g/L and 0.68 mu g/L, respectively. Log(10)-transformed 3-PBA concentrations were associated with adjusted odds ratios (ORs) of 1.18 (95% CI: 0.92, 1.51) for parent-reported LD, 1.16 (95% CI: 0.85, 1.58) for ADHD, and 1.45 (95% CI: 0.92, 2.27) for both LD and ADHD. Adjusted ORs remained nonsignificant and decreased after controlling for creatinine and other environmental chemicals previously linked to altered neurodevelopment. Similarly, no significant associations were observed for cis-and trans-DCCA.
CONCLUSIONS: Postnatal pyrethroid exposure was not associated with parental report of LD and/or ADHD. Given the widespread and increasing use of pyrethroids, future research should evaluate exposures at current levels, particularly during critical windows of brain development.
C1 [Quiros-Alcala, Lesliam; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94706 USA.
[Mehta, Suril] US EPA, Offc Childrens Hlth Protect, Washington, DC 20460 USA.
RP Quiros-Alcala, L (reprint author), Univ Calif Berkeley, Sch Publ Hlth, CERCH, 1995 Univ Ave,Suite 265, Berkeley, CA 94706 USA.
EM lquiros@berkeley.edu
RI Quiros-Alcala, Lesliam /Q-4928-2016
OI Quiros-Alcala, Lesliam /0000-0002-6600-7227
FU Science Innovation Fund from the Passport Foundation; National Institute
of Environmental Health Sciences [PO1ES009605]; U.S. EPA [RD83451301]
FX The National Health and Nutrition Examination Survey was conducted by
the National Center for Health Statistics, and the data analysis for
this research was funded by a Science Innovation Fund from the Passport
Foundation. Additional funding was received from the National Institute
of Environmental Health Sciences (PO1ES009605) and the U.S. EPA
(RD83451301).
NR 51
TC 12
Z9 12
U1 7
U2 25
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2014
VL 122
IS 12
BP 1336
EP 1342
DI 10.1289/ehp.1308031
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YC
UT WOS:000347384600023
PM 25192380
ER
PT J
AU Rossmann, R
Pfeiffer, EL
Filkins, JC
AF Rossmann, Ronald
Pfeiffer, Erika L.
Filkins, John C.
TI Lake Michigan sediment lead storage and history of loads
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Lake Michigan; Lead; Loads; Storage
ID GREEN BAY; MERCURY; DEPOSITION; RECORD; FLUXES; POLLUTION; METALS;
CORES; CADMIUM; POLLUTANTS
AB Dated sediment box cores collected in 1994-1996 from 52 locations in Lake Michigan were analyzed to assess storage, trends, and loading history of lead. The results of this study provide information of historic lead loads to the lake for a time period (pre-1960) for which no reliable lead measurements exist. The information can be utilized by those wishing to model lead and to access lead loading trends. Anthropogenic lead storage in the lake's sediments totaled 143,000 t as of 1994. Storage of acid-extractable total (anthropogenic + background) lead totaled 171,000 t between 1850 and 1994. The date of 1850 is the time at which lead loads increased above background loads (219 t/y) to the lake. Anthropogenic loads peaked between 1959 and 1962 at 2440 t/y and were 1170 t/y between 1994 and 1995, illustrating that at the time of collection in 1994, loads were decreasing from previous highs. The load in 1994 to 1995 was equivalent to the load during the time frame of 1922 to 1925. Largest lead loads were to southeastern Lake Michigan in a region downwind of Chicago, illustrating the impact of large populated areas utilizing coal and gasoline on lead loads to the lake. Loading trends were impacted by coal and gasoline consumption, increased industrial activity during World War II, the Clean Air Act of 1970, and the phase-out of leaded gasoline. (C) 2014 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved.
C1 [Rossmann, Ronald] Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Pfeiffer, Erika L.] Z Tech Corp, ICF Co, Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Filkins, John C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Large Lakes, Midcontinent Ecol Div,Large Lakes & Rivers Foreca, Grosse Ile, MI 48138 USA.
RP Rossmann, R (reprint author), Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM ronaldrossmann@hotmail.com
NR 63
TC 0
Z9 0
U1 1
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD DEC
PY 2014
VL 40
IS 4
BP 851
EP 858
DI 10.1016/j.jglr.2014.08.008
PG 8
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AY0FX
UT WOS:000347274000004
ER
PT J
AU Chorley, B
Ward, W
Simmons, SO
Vallanat, B
Veronesi, B
AF Chorley, Brian
Ward, William
Simmons, Steven O.
Vallanat, Beena
Veronesi, Bellina
TI The cellular and genomic response of rat dopaminergic neurons (N27) to
coated nanosilver
SO NEUROTOXICOLOGY
LA English
DT Article
DE Nanotoxicity; Nanosilver; "Capping"; Surface coating;
Polyvinylpyrrolidone
ID SILVER NANOPARTICLES; PARKINSONS-DISEASE; OXIDATIVE STRESS; IN-VITRO;
PROTEOLYTIC ACTIVATION; BRAIN MICROGLIA; CULTURE MODEL; PARTICLE-SIZE;
BV2 MICROGLIA; NANO-SILVER
AB This study examined if nanosilver (nanoAg) of different sizes and coatings were differentially toxic to oxidative stress-sensitive neurons. N27 rat dopaminergic neurons were exposed (0.5-5 ppm) to a set of nanoAg of different sizes (10 nm, 75 nm) and coatings (PVP, citrate) and their physicochemical, cellular and genomic response measured. Both coatings retained their manufactured sizes in culture media, however, the zeta potentials of both sizes of PVP-coated nanoAg were significantly less electronegative than those of their citrate-coated counterparts. Markers of oxidative stress, measured at 0.5-5 ppm exposure concentrations, indicated that caspase 3/7 activity and glutathione levels were significantly increased by both sizes of PVP-coated nanoAg and by the 75 nm citrate-coated nanoAg. Both sizes of PVP-coated nanoAg also increased intra-neuronal nitrite levels and activated ARE/NRF2, a reporter gene for the oxidative stress-protection pathway. Global gene expression on N27 neurons, exposed to 0.5 ppm for 8 h, indicated a dominant effect by PVP-coated nanoAg over citrate. The 75 nm PVP-coated material altered 196 genes that were loosely associated with mitochondrial dysfunction. In contrast, the 10 nm PVP-coated nanoAg altered 82 genes that were strongly associated with NRF2 oxidative stress pathways. Less that 20% of the affected genes were shared by both sizes of PVP-coated nanoAg. These cellular and genomic findings suggest that PVP-coated nanoAg is more bioactive than citrate-coated nanoAg.. Although both sizes of PVP-coated nanoAg altered the genomic expression of N27 neurons along oxidative stress pathways, exposure to the 75 nm nanoAg favored pathways associated with mitochondrial dysfunction, whereas the 10 nm PVP-coated nanoAg affected NRF2 neuronal protective pathways. Published by Elsevier Inc.
C1 [Chorley, Brian; Simmons, Steven O.; Veronesi, Bellina] Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Ward, William; Vallanat, Beena] US EPA, Res Genom Core, Res Triangle Pk, NC 27711 USA.
RP Veronesi, B (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, B105-06, Res Triangle Pk, NC 27711 USA.
EM veronesi.bellina@epa.gov
OI Simmons, Steven/0000-0001-9079-1069
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the view of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 86
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Z9 1
U1 4
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD DEC
PY 2014
VL 45
BP 12
EP 21
DI 10.1016/j.neuro.2014.08.010
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA AX5GQ
UT WOS:000346955100002
PM 25194297
ER
PT J
AU Lantz, SR
Mack, CM
Wallace, K
Key, EF
Shafer, TJ
Casida, JE
AF Lantz, Stephen R.
Mack, Cina M.
Wallace, Kathleen
Key, Ellen F.
Shafer, Timothy J.
Casida, John E.
TI Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal
network activity in vitro
SO NEUROTOXICOLOGY
LA English
DT Article
DE Glufosinate; Neurotoxicity; N-Methyl-D-aspartate receptor;
N-Acetylglufosinate
ID GAMMA-SUBSTITUTED PHOSPHINOTHRICINS; COLI GLUTAMINE-SYNTHETASE;
HERBICIDE-RESISTANT CROPS; AMINO-ACID TRANSPORTERS; H-3 CGP-39653
BINDING; RAT-BRAIN; ESCHERICHIA-COLI; MEDIATED EXCITOTOXICITY;
MICROELECTRODE ARRAYS; SEVERE NEUROTOXICITY
AB Glufosinate (GLF) at high levels in mammals causes convulsions and amnesia through a mechanism that is not completely understood. The structural similarity of GLF to glutamate (GLU) implicates the glutamatergic system as a target for GLF neurotoxicity. The current work examined in vitro GLF interaction with N-methyl-D-aspartate subtype GLU receptors (NMDARs) and GLT-1 transporters via [H-3]CGP 39653 binding experiments and [H-3]GLU uptake assays, respectively. GLF effects on neuronal network activity were assessed using microelectrode array (MEA) recordings in primary cultures of cortical neurons. GLF and its primary metabolite N-acetylglufosinate (NAcGLF) bind to the NMDAR; the IC50 value for GLF was 668 mu M and for NAcGLF was about 100 mu M. Concentrations of GLF greater than 1000 mu M were needed to decrease,GLU uptake through GLT-1. In MEA recordings from networks of rat primary cortical neurons, the concentration-responses for NMDA, GLF and NAcGLF on network mean firing rates (MFR) were biphasic, increasing at lower concentrations and decreasing below control levels at higher concentrations. Increases in MFR occurred between 3-10 mu M NMDA (290% control, maximum), 100-300 mu M NAcGLF (190% control, maximum) and 10-1000 mu M GLF (340% control, maximum). The NMDAR antagonist MK801 attenuated both NMDA and GLF increases in MFR. The GLF concentration required to alter GLU transport through GLT-1 is not likely to be attained in vivo, and therefore not relevant to the neurotoxic mode of action. However, toxicokinetic data from reports of intentional human poisonings indicate that GLF concentrations in the CNS after acute exposure could reach levels high enough to lead to effects mediated via NMDARs. Furthermore, the newly characterized action of NAcGLF at the NMDAR suggests that both the parent compound and metabolite could contribute to neurotoxicity via this pathway. Published by Elsevier Inc.
C1 [Lantz, Stephen R.; Key, Ellen F.; Casida, John E.] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Environm Chem & Toxicol Lab, Berkeley, CA 94720 USA.
[Mack, Cina M.; Wallace, Kathleen; Shafer, Timothy J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lantz, SR (reprint author), US Fish & Wildlife Serv, Marquette Biol Stn, 3090 Wright St, Marquette, MI 49855 USA.
EM stephen_lantz@fws.gov
OI Shafer, Timothy/0000-0002-8069-9987
FU STAR Fellowship Assistance - U.S. Environmental Protection Agency (EPA)
[FP917139]; UC Berkeley Sponsored Project for Undergraduate Research
(SPUR) Grant
FX S.R.L. was funded by STAR Fellowship Assistance Agreement number
FP917139 awarded by the U.S. Environmental Protection Agency (EPA).
E.F.K. was funded by a UC Berkeley Sponsored Project for Undergraduate
Research (SPUR) Grant. This document has been reviewed by the U.S. EPA's
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
The findings and conclusions in this article are those of the authors
and do not necessarily represent the views of the U.S. Fish and Wildlife
Service.
NR 71
TC 6
Z9 6
U1 4
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD DEC
PY 2014
VL 45
BP 38
EP 47
DI 10.1016/j.neuro.2014.09.003
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA AX5GQ
UT WOS:000346955100005
PM 25268653
ER
PT J
AU Reich, BJ
Chang, HH
Foley, KM
AF Reich, Brian J.
Chang, Howard H.
Foley, Kristen M.
TI A Spectral Method for Spatial Downscaling
SO BIOMETRICS
LA English
DT Article
DE Computer model output; Data fusion; Kriging; Multiscale analysis
ID AIR-POLLUTION; NUMERICAL-MODELS; OUTPUT; OZONE; SENSITIVITY; COMPONENT
AB Complex computer models play a crucial role in air quality research. These models are used to evaluate potential regulatory impacts of emission control strategies and to estimate air quality in areas without monitoring data. For both of these purposes, it is important to calibrate model output with monitoring data to adjust for model biases and improve spatial prediction. In this article, we propose a new spectral method to study and exploit complex relationships between model output and monitoring data. Spectral methods allow us to estimate the relationship between model output and monitoring data separately at different spatial scales, and to use model output for prediction only at the appropriate scales. The proposed method is computationally efficient and can be implemented using standard software. We apply the method to compare Community Multiscale Air Quality (CMAQ) model output with ozone measurements in the United States in July 2005. We find that CMAQ captures large-scale spatial trends, but has low correlation with the monitoring data at small spatial scales.
C1 [Reich, Brian J.] N Carolina State Univ, Raleigh, NC 27695 USA.
[Chang, Howard H.] Emory Univ, Atlanta, GA 30322 USA.
[Foley, Kristen M.] US EPA, Washington, DC 20460 USA.
RP Reich, BJ (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA.
EM bjreich@ncsu.edu
FU USEPA [R835228, R834799]; NSF [1107046]; NIH [R01ES014843, R01ES019897,
R21ES022795-01A1]; United States Environmental Protection Agency through
its Office of Research and Development
FX The authors thank James Hodges (University of Minnesota) and Joseph
Guinness (North Carolina State University) for fruitful discussions
about this work. This study was partially supported by USEPA grants
R835228 and R834799, NSF grant 1107046, and NIH grants R01ES014843,
R01ES019897, and R21ES022795-01A1. Its contents are solely the
responsibility of the grantee and do not necessarily represent the
official views of the USEPA. Further, USEPA does not endorse the
purchase of any commercial products or services mentioned in the
publication. The United States Environmental Protection Agency through
its Office of Research and Development partially funded and collaborated
in the research described here. It has been subjected to Agency review
and approved for publication.
NR 44
TC 3
Z9 3
U1 1
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0006-341X
EI 1541-0420
J9 BIOMETRICS
JI Biometrics
PD DEC
PY 2014
VL 70
IS 4
BP 932
EP 942
DI 10.1111/biom.12196
PG 11
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology; Mathematics
GA AX3GF
UT WOS:000346827500017
PM 24965037
ER
PT J
AU Daston, GP
Beyer, BK
Carney, EW
Chapin, RE
Friedman, JM
Piersma, AH
Rogers, JM
Scialli, AR
AF Daston, George P.
Beyer, Bruce K.
Carney, Edward W.
Chapin, Robert E.
Friedman, Jan M.
Piersma, Aldert H.
Rogers, John M.
Scialli, Anthony R.
TI Exposure-Based Validation List for Developmental Toxicity Screening
Assays
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE in vitro methods; validation; developmental toxicity
ID TRANS-RETINOIC ACID; SPRAGUE-DAWLEY RATS; ETHYLENE-GLYCOL; PREGNANT
RATS; NONLINEAR PHARMACOKINETICS; PRENATAL TOXICITY; EMBRYOTOXICITY;
ARTESUNATE; SACCHARIN; KINETICS
AB Validation of alternative assays requires comparison of the responses to toxicants in the alternative assay with in vivo responses. Chemicals have been classified as positive or negative in vivo, despite the fact that developmental toxicity is conditional on magnitude of exposure. We developed a list of positive and negative developmental exposures, with exposure defined by toxicokinetic data, specifically maternal plasma C-max. We selected a series of 20 chemicals that caused developmental toxicity and for which there were appropriate toxicokinetic data. Where possible, we used the same chemical for both positive and negative exposures, the positive being the C-max at a dose level that produced significant teratogenicity or embryolethality, the negative being the C-max at a dose level not causing developmental toxicity. It was not possible to find toxicokinetic data at the no-effect level for all positive compounds, and the negative exposure list contains C-max values for some compounds that do not have developmental toxicity up to the highest dose level tested. This exposure-based reference list represents a fundamentally different approach to the evaluation of alternative tests and is proposed as a step toward application of alternative tests in quantitative risk assessment (C) 2014 Wiley Periodicals, Inc.
C1 [Daston, George P.] Procter & Gamble, Cincinnati, OH USA.
[Beyer, Bruce K.] Sanofi US Inc, Dept Disposit Safety & Anim Res Preclin Safety, Bridgewater, NJ USA.
[Carney, Edward W.] Dow Chem Co USA, Midland, MI 48674 USA.
[Chapin, Robert E.] Pfizer Worldwide R&D, Groton, CT USA.
[Friedman, Jan M.] Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Vancouver, BC V5Z 1M9, Canada.
[Piersma, Aldert H.] RIVM, Utrecht, Netherlands.
[Piersma, Aldert H.] Univ Utrecht, IRAS, Utrecht, Netherlands.
[Rogers, John M.] US EPA, Tox Assessment Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
[Scialli, Anthony R.] Reprod Toxicol Ctr, Washington, DC USA.
[Scialli, Anthony R.] George Washington Univ, Sch Med, Washington, DC USA.
RP Scialli, AR (reprint author), Reprod Toxicol Ctr, 2737 Devonshire Pl NW 120, Washington, DC 20008 USA.
EM reprotox@reprotox.org
OI Friedman, Jan/0000-0002-7482-9570
FU HESI DART Technical Committee
FX Grant sponsor: HESI DART Technical Committee.
NR 52
TC 8
Z9 8
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-9733
EI 1542-9741
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD DEC
PY 2014
VL 101
IS 6
BP 423
EP 428
DI 10.1002/bdrb.21132
PG 6
WC Oncology; Genetics & Heredity; Toxicology
SC Oncology; Genetics & Heredity; Toxicology
GA AX1KF
UT WOS:000346705300003
PM 25475026
ER
PT J
AU Snyder, M
Arunachalam, S
Isakov, V
Talgo, K
Naess, B
Valencia, A
Omary, M
Davis, N
Cook, R
Hanna, A
AF Snyder, Michelle
Arunachalam, Saravanan
Isakov, Vlad
Talgo, Kevin
Naess, Brian
Valencia, Alejandro
Omary, Mohammad
Davis, Neil
Cook, Rich
Hanna, Adel
TI Creating Locally-Resolved Mobile-Source Emissions Inputs for Air Quality
Modeling in Support of an Exposure Study in Detroit, Michigan, USA
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE dispersion models; mobile-source emissions; uncertainties in emissions;
R-LINE; human exposure; NEXUS
ID NEAR-ROAD EXPOSURES; DISPERSION MODEL; POLLUTANTS; NEXUS
AB This work describes a methodology for modeling the impact of traffic-generated air pollutants in an urban area. This methodology presented here utilizes road network geometry, traffic volume, temporal allocation factors, fleet mixes, and emission factors to provide critical modeling inputs. These inputs, assembled from a variety of sources, are combined with meteorological inputs to generate link-based emissions for use in dispersion modeling to estimate pollutant concentration levels due to traffic. A case study implementing this methodology for a large health study is presented, including a sensitivity analysis of the modeling results reinforcing the importance of model inputs and identify those having greater relative impact, such as fleet mix. In addition, an example use of local measurements of fleet activity to supplement model inputs is described, and its impacts to the model outputs are discussed. We conclude that with detailed model inputs supported by local traffic measurements and meteorology, it is possible to capture the spatial and temporal patterns needed to accurately estimate exposure from traffic-related pollutants.
C1 [Snyder, Michelle; Arunachalam, Saravanan; Talgo, Kevin; Naess, Brian; Valencia, Alejandro; Omary, Mohammad; Davis, Neil; Hanna, Adel] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA.
[Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Cook, Rich] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA.
RP Snyder, M (reprint author), Univ N Carolina, Inst Environm, 100 Europa Dr,Suite 490, Chapel Hill, NC 27517 USA.
EM michellesnyder@unc.edu; sarav@email.unc.edu; isakov.vlad@epa.gov;
talgo@email.unc.edu; naess@unc.edu; valenal@email.unc.edu;
omary@email.unc.edu; Neda@dtu.dk; cook.rich@epa.gov;
ahanna@email.unc.edu
OI Davis, Neil/0000-0001-5886-247X
FU U.S. Environmental Protection Agency [EP-D-07-102, EP-W-09-023]
FX The authors would like to thank Stuart Batterman and his team at the
University of Michigan for their collaboration and efforts in NEXUS. We
would also like to thank Bok Haeng Baek of the UNC's Institute for the
Environment for assistance with the NEI's temporal profiles, the
Southeast Michigan Council of Government (SEMCOG) for providing the TDM
outputs, and the Michigan DOT for providing the PTR data used in the
sensitivity analyses. The U.S. Environmental Protection Agency, through
its Office of Research and Development, partially funded and
collaborated in the research described here under Contract Nos.
EP-D-07-102 and EP-W-09-023 to the University of North Carolina at
Chapel Hill. This paper has been subjected to Agency review and approved
for publication. Approval does not signify that the contents reflect the
views of the Agency nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 17
TC 3
Z9 3
U1 2
U2 5
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2014
VL 11
IS 12
BP 12739
EP 12766
DI 10.3390/ijerph111212739
PG 28
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2TJ
UT WOS:000346797100043
PM 25501000
ER
PT J
AU Lane, CR
Liu, HX
Autrey, BC
Anenkhonov, OA
Chepinoga, VV
Wu, QS
AF Lane, Charles R.
Liu, Hongxing
Autrey, Bradley C.
Anenkhonov, Oleg A.
Chepinoga, Victor V.
Wu, Qiusheng
TI Improved Wetland Classification Using Eight-Band High Resolution
Satellite Imagery and a Hybrid Approach
SO REMOTE SENSING
LA English
DT Article
DE Selenga River delta; Lake Baikal; coastal band; NIR2 band; NDVI;
grey-level co-occurrence matrix; image texture; Worldview-2
ID THEMATIC MAPPER IMAGERY; SUBPIXEL CLASSIFICATION; MAPPING WETLANDS;
UNITED-STATES; ETM+ IMAGERY; TM IMAGERY; WORLDVIEW-2; VEGETATION; TREES;
AREA
AB Although remote sensing technology has long been used in wetland inventory and monitoring, the accuracy and detail level of wetland maps derived with moderate resolution imagery and traditional techniques have been limited and often unsatisfactory. We explored and evaluated the utility of a newly launched high-resolution, eight-band satellite system (Worldview-2; WV2) for identifying and classifying freshwater deltaic wetland vegetation and aquatic habitats in the Selenga River Delta of Lake Baikal, Russia, using a hybrid approach and a novel application of Indicator Species Analysis (ISA). We achieved an overall classification accuracy of 86.5% (Kappa coefficient: 0.85) for 22 classes of aquatic and wetland habitats and found that additional metrics, such as the Normalized Difference Vegetation Index and image texture, were valuable for improving the overall classification accuracy and particularly for discriminating among certain habitat classes. Our analysis demonstrated that including WV2's four spectral bands from parts of the spectrum less commonly used in remote sensing analyses, along with the more traditional bandwidths, contributed to the increase in the overall classification accuracy by similar to 4% overall, but with considerable increases in our ability to discriminate certain communities. The coastal band improved differentiating open water and aquatic (i.e., vegetated) habitats, and the yellow, red-edge, and near-infrared 2 bands improved discrimination among different vegetated aquatic and terrestrial habitats. The use of ISA provided statistical rigor in developing associations between spectral classes and field-based data. Our analyses demonstrated the utility of a hybrid approach and the benefit of additional bands and metrics in providing the first spatially explicit mapping of a large and heterogeneous wetland system.
C1 [Lane, Charles R.; Autrey, Bradley C.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Liu, Hongxing; Wu, Qiusheng] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA.
[Liu, Hongxing; Wu, Qiusheng] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
[Anenkhonov, Oleg A.] Russian Acad Sci, Inst Gen & Expt Biol, Siberian Branch, Ulan Ude 670047, Russia.
[Chepinoga, Victor V.] Irkutsk State Univ, Dept Bot & Genet, Irkutsk 664003, Russia.
[Chepinoga, Victor V.] Russian Acad Sci, Inst Geog, Siberian Branch, Irkutsk 664003, Russia.
RP Lane, CR (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM Lane.Charles@epa.gov; Liu.Hongxing@epa.gov; Autrey.Brad@epa.gov;
Anen@yandex.ru; victor.chepinoga@gmail.com; Wu.Qiusheng@epa.gov
RI Wu, Qiusheng/C-7976-2016; Anenkhonov, Oleg/J-8690-2016
OI Wu, Qiusheng/0000-0001-5437-4073; Anenkhonov, Oleg/0000-0001-8633-7154
FU U.S. Environmental Protection Agency Office of Research and Development
[EP-D-06-096]; U.S. Department of State, Biochemical Redirect Program;
International Science and Technology Center, Moscow, Russia
FX The U.S. Environmental Protection Agency Office of Research and
Development partially funded and collaborated in the research described
here under contract number EP-D-06-096 to Dynamac Corporation. The
research conducted herein was also partially funded by the U.S.
Department of State, Biochemical Redirect Program with support from the
International Science and Technology Center, Moscow, Russia. We
appreciate the technical review and feedback provided by John Lin, U.S.
EPA, and the programmatic support of Doug Steele, U.S. EPA. This paper
has been reviewed in accordance with the U.S. Environmental Protection
Agency's peer and administrative review policies and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. Statements in this
publication reflect the authors' professional views and opinions and
should not be construed to represent any determination or policy of the
U.S. Environmental Protection Agency.
NR 68
TC 9
Z9 10
U1 7
U2 42
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-4292
J9 REMOTE SENS-BASEL
JI Remote Sens.
PD DEC
PY 2014
VL 6
IS 12
BP 12187
EP 12216
DI 10.3390/rs61212187
PG 30
WC Remote Sensing
SC Remote Sensing
GA AX2ST
UT WOS:000346795300024
ER
PT J
AU Eudy, AM
Vines, AI
Dooley, MA
Cooper, GS
Parks, CG
AF Eudy, A. M.
Vines, A. I.
Dooley, M. A.
Cooper, G. S.
Parks, C. G.
TI Elevated C-reactive protein and self-reported disease activity in
systemic lupus erythematosus
SO LUPUS
LA English
DT Article
DE Systemic lupus erythematosus; C-reactive protein; flares; socioeconomic
factors
ID ERYTHROCYTE SEDIMENTATION-RATE; SOUTHEASTERN UNITED-STATES;
RHEUMATOID-ARTHRITIS; ACTIVITY QUESTIONNAIRE; SOCIOECONOMIC-STATUS;
REVISED CRITERIA; HEALTH; DAMAGE; VALIDATION; AMERICAN
AB C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased disease activity in rheumatoid arthritis. However, the association in systemic lupus erythematosus (SLE) remains unclear. We examined the association of CRP with self-reported disease activity in the Carolina Lupus Study and described differences by sociodemographic characteristics. The study included baseline and three-year follow-up data on 107 African-American and 69 Caucasian SLE patients enrolled at a median 13 months since diagnosis. Models estimated prevalence differences in the association of baseline CRP with self-reported flares, adjusting for age, sex, race and education. Active disease or flare was reported by 59% at baseline and 58% at follow-up. Higher CRP (> 10 mu g/ml vs. <3 mu g/ml) was associated with a 17% (95% confidence interval (CI): -20, 53%) higher prevalence of flare at baseline and a 26% (95% CI: -9, 62%) higher prevalence of flare at follow-up. These CRP-flare associations were notably stronger in patients with lower education at baseline and in African-Americans at follow-up. These findings suggest that CRP may be a useful marker in studies of SLE health disparities.
C1 [Eudy, A. M.; Vines, A. I.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
[Dooley, M. A.] Univ N Carolina, Chapel Hill, NC 27599 USA.
[Cooper, G. S.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Parks, C. G.] NIEHS, Epidemiol Branch, NIH, DHHS, Durham, NC USA.
RP Eudy, AM (reprint author), Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Campus Box 7435, Chapel Hill, NC 27599 USA.
EM aeudy@email.unc.edu
OI Eudy, Amanda/0000-0002-3107-5545; Parks, Christine/0000-0002-5734-3456
FU Intramural Research Program of the NIEHS; National Center for Minority
Health and Health Disparities of the NIH
FX This work was supported by the Intramural Research Program of the NIEHS
and the National Center for Minority Health and Health Disparities of
the NIH.
NR 36
TC 3
Z9 3
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0961-2033
EI 1477-0962
J9 LUPUS
JI Lupus
PD DEC
PY 2014
VL 23
IS 14
BP 1460
EP 1467
DI 10.1177/0961203314543915
PG 8
WC Rheumatology
SC Rheumatology
GA AW3HK
UT WOS:000346177000003
PM 25057037
ER
PT J
AU Schaa, KL
Anderson, G
Alt-White, AC
Kasper, CE
Boyd, AM
AF Schaa, Kendra L.
Anderson, Gwen
Alt-White, Anna C.
Kasper, Christine E.
Boyd, Andrea M.
TI Genomics education for Veterans Affairs nurses
SO GENETICS IN MEDICINE
LA English
DT Letter
C1 [Anderson, Gwen; Alt-White, Anna C.; Kasper, Christine E.] Off Nursing Serv, Dept Vet Affairs, Washington, DC USA.
[Boyd, Andrea M.] Wm Jennings Bryan Dorn VA Med Ctr, Dept Vet Affairs, Columbia, SC USA.
RP Schaa, KL (reprint author), US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20460 USA.
EM Kendra.schaa@va.gov
OI Schaa, Kendra/0000-0002-4460-5357; Anderson, Gwen/0000-0003-2046-3152
NR 3
TC 1
Z9 1
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1098-3600
EI 1530-0366
J9 GENET MED
JI Genet. Med.
PD DEC
PY 2014
VL 16
IS 12
BP 984
EP 985
DI 10.1038/gim.2014.142
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA AW1HN
UT WOS:000346040900019
PM 25469615
ER
PT J
AU Baker, KR
Hawkins, A
Kelly, JT
AF Baker, Kirk R.
Hawkins, Andy
Kelly, James T.
TI Photochemical grid model performance with varying horizontal grid
resolution and sub-grid plume treatment for the Martins Creek nearfield
SO2 study
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE CAMx; Dispersion; Air quality modeling; Grid resolution; Sub-grid plume;
Martins Creek
ID MESOSCALE METEOROLOGICAL MODEL; ATMOSPHERIC BOUNDARY-LAYER; NONLOCAL
CLOSURE-MODEL; LAND-SURFACE MODEL; PART II; DISPERSION MODEL;
POWER-PLANT; SCALE; TRANSPORT; SCHEME
AB Near source modeling is needed to assess primary and secondary pollutant impacts from single sources and single source complexes. Source receptor relationships need to be resolved from tens of meters to tens of kilometers. Dispersion models are typically applied for near-source primary pollutant impacts but lack complex photochemistry. Photochemical models provide a realistic chemical environment but are typically applied using grid cell sizes that may be larger than the distance between sources and receptors. It is important to understand the impacts of grid resolution and sub-grid plume treatments on photochemical modeling of near-source primary pollution gradients. Here, the CAMx photochemical grid model is applied using multiple grid resolutions and sub-grid plume treatment for SO2 and compared with a receptor mesonet largely impacted by nearby sources approximately 3-17 km away in a complex terrain environment. Measurements are compared with model estimates of SO2 at 4- and 1-km resolution, both with and without sub-grid plume treatment and inclusion of finer two-way grid nests. Annual average estimated SO2 mixing ratios are highest nearest the sources and decrease as distance from the sources increase. In general, CAMx estimates of SO2 do not compare well with the near-source observations when paired in space and time. Given the proximity of these sources and receptors, accuracy in wind vector estimation is critical for applications that pair pollutant predictions and observations in time and space. In typical permit applications, predictions and observations are not paired in time and space and the entire distributions of each are directly compared. Using this approach, model estimates using 1-km grid resolution best match the distribution of observations and are most comparable to similar studies that used dispersion and Lagrangian modeling systems. Model-estimated SO2 increases as grid cell size decreases from 4 km to 250 m. However, it is notable that the 1-km model estimates using 1-km meteorological model input are higher than the 1-km model simulation that used interpolated 4-km meteorology. The inclusion of sub-grid plume treatment did not improve model skill in predicting SO2 in time and space and generally acts to keep emitted mass aloft. Published by Elsevier Ltd.
C1 [Baker, Kirk R.; Kelly, James T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Hawkins, Andy] US EPA, Lenexa, KS 66219 USA.
RP Baker, KR (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM baker.kirk@epa.gov
RI Kelly, James/F-8135-2010
OI Kelly, James/0000-0001-6574-5714
NR 36
TC 2
Z9 3
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 99
BP 148
EP 158
DI 10.1016/j.atmosenv.2014.09.064
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU7TS
UT WOS:000345804400017
ER
PT J
AU Jing, P
Lu, ZF
Xing, J
Streets, DG
Tan, Q
O'Brien, T
Kamberos, J
AF Jing, Ping
Lu, Zifeng
Xing, Jia
Streets, David G.
Tan, Qian
O'Brien, Timothy
Kamberos, Joseph
TI Response of the summertime ground-level ozone trend in the Chicago area
to emission controls and temperature changes, 2005-2013
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Ozone trend; Temperature dependence of ozone; NOx and VOC emission
control; Chicago
ID UNITED-STATES; MONITORING INSTRUMENT; NOX EMISSIONS; URBAN AREAS;
POWER-PLANTS; MEXICO-CITY; METEOROLOGY; RETRIEVALS; STRATEGIES;
INDUSTRIAL
AB Despite strenuous efforts to reduce the emissions of ozone precursors such as nitrogen oxides (NOx), concentrations of ground-level ozone (O-3) still often exceed the National Ambient Air Quality Standard in U.S. cities in summertime, including Chicago. Furthermore, studies have projected a future increase in O-3 formation due to global climate change. This study examines the response of summertime O-3 to emission controls and temperature change in the Chicago area from 2005 to 2013 by employing observations of O-3, O-3 precursors, and meteorological variables. We find that meteorology explains about 53% of the O-3 variance in Chicago. O-3 mixing ratios over Chicago are found to show no clear decline over the 2005-2013 period. The summertime ground-level O-3 trend consists of a decrease of 0.08 ppb/year between 2005 and 2009 and an increase of 1.49 ppb/year between 2009 and 2013. Emissions of NOx and concentrations of NO2 have been decreasing steadily from 2005 to 2013 in the Chicago area. Concentrations of volatile organic compounds (VOCs) in Chicago, however, have more than doubled since 2009, even though emission inventories suggest that VOC emissions have decreased. We believe that O-3 production in Chicago became more sensitive to VOCs starting in 2008/2009 and may have switched from being NOx-limited to VOC-limited. The warmer climate since 2008 has also contributed to the increasing ozone trend in the Chicago area. Increased attention should be paid to improving the quantification of VOC sources, enhancing the monitoring of reactive VOC concentrations, and designing VOC mitigation measures. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jing, Ping; Kamberos, Joseph] Loyola Univ, Inst Environm Sustainabil, Chicago, IL 60660 USA.
[Lu, Zifeng; Streets, David G.] Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA.
[Xing, Jia] US EPA, Res Triangle Pk, NC 27711 USA.
[Tan, Qian] NASA, Goddard Earth Sci Technol & Res GESTAR Studies &, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[O'Brien, Timothy] Loyola Univ, Dept Math & Stat, Chicago, IL 60660 USA.
RP Jing, P (reprint author), Loyola Univ, Inst Environm Sustainabil, Chicago, IL 60660 USA.
EM pjing@luc.edu
RI xing, jia/O-1784-2014
FU Loyola University Chicago Summer Research Stipends
FX This work was funded by the Loyola University Chicago Summer Research
Stipends. We thank Gao Chen from NASA's Langley Research Center for
helpful comments.
NR 37
TC 5
Z9 5
U1 7
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 99
BP 630
EP 640
DI 10.1016/j.atmosenv.2014.10.035
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU7TS
UT WOS:000345804400066
ER
PT J
AU Wall, EH
Hewitt, SC
Case, LK
Lin, CY
Korach, KS
Teuscher, C
AF Wall, Emma H.
Hewitt, Sylvia C.
Case, Laure K.
Lin, Chin-Yo
Korach, Kenneth S.
Teuscher, Cory
TI The role of genetics in estrogen responses: a critical piece of an
intricate puzzle
SO FASEB JOURNAL
LA English
DT Review
DE genotype; reproductive tissue
ID MAMMARY-GLAND DEVELOPMENT; ESTRADIOL-REGULATED RESPONSES; QUANTITATIVE
TRAIT LOCI; BREAST-CANCER CELLS; X ACI INTERCROSS; RECEPTOR-ALPHA;
FEMALE MICE; IN-VIVO; OPPOSITE-SEX; BISPHENOL-A
AB The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth. They are mainly known for their roles in reproductive tissues-specifically, 17 beta-estradiol (E-2), the primary estrogen, which is secreted by the ovaries and induces cellular proliferation and growth of the uterus and mammary glands. In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues. The responsiveness of various tissues to estrogen is genetically controlled, with marked quantitative variation observed across multiple species, including humans. This variation presents both researchers and clinicians with a veritable physiological puzzle, the pieces of which-many of them unknown-are complex and difficult to fit together. Although genetics is known to play a major role in determining sensitivity to estrogens, there are other factors, including parent of origin and the maternal environment, that are intimately linked to heritable phenotypes but do not represent genotype, per se. The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.
C1 [Wall, Emma H.; Case, Laure K.; Teuscher, Cory] Univ Vermont, Dept Med & Pathol, Burlington, VT 05405 USA.
[Hewitt, Sylvia C.; Korach, Kenneth S.] US Natl Inst Hlth, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Lin, Chin-Yo] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA.
RP Teuscher, C (reprint author), Univ Vermont, C331 Given Med Bldg, Burlington, VT 05405 USA.
EM c.teuscher@uvm.edu
OI Korach, Kenneth/0000-0002-7765-418X
FU Intramural Research Program of the U.S. National Institutes of Health,
National Institute of Environmental Health Sciences grant [Z01ES70065]
FX This research was supported, in part, by the Intramural Research Program
of the U.S. National Institutes of Health, National Institute of
Environmental Health Sciences grant Z01ES70065.
NR 137
TC 4
Z9 4
U1 0
U2 7
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC
PY 2014
VL 28
IS 12
BP 5042
EP 5054
DI 10.1096/fj.14-260307
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA AU9EN
UT WOS:000345894500003
PM 25212221
ER
PT J
AU Harrison, MD
Miller, AJ
Groffman, PM
Mayer, PM
Kaushal, SS
AF Harrison, Melanie D.
Miller, Andrew J.
Groffman, Peter M.
Mayer, Paul M.
Kaushal, Sujay S.
TI HYDROLOGIC CONTROLS ON NITROGEN AND PHOSPHOROUS DYNAMICS IN RELICT OXBOW
WETLANDS ADJACENT TO AN URBAN RESTORED STREAM
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE denitrification; hydrology; nitrogen; phosphorus; stream restoration;
wetlands; urban
ID UPPER KLAMATH LAKE; NUTRIENT RETENTION; CONSTRUCTED WETLANDS; CHESAPEAKE
BAY; RESTORATION WETLAND; SUBSURFACE DRAINAGE; RIVERINE WETLANDS;
MISSISSIPPI RIVER; DEGRADED URBAN; DENITRIFICATION
AB Although wetlands are known to be sinks for nitrogen (N) and phosphorus (P), their function in urban watersheds remains unclear. We analyzed water and nitrate (NO3-) and phosphate (PO43-) dynamics during precipitation events in two oxbow wetlands that were created during geomorphic stream restoration in Baltimore County, Maryland that varied in the nature and extent of connectivity to the adjacent stream. Oxbow 1 (Ox1) received 1.6-4.2% and Oxbow 2 (Ox2) received 4.2-7.4% of cumulative streamflow during storm events from subsurface seepage (Ox1) and surface flow (Ox2). The retention time of incoming stormwater ranged from 0.2 to 6.7days in Ox1 and 1.8 to 4.3days in Ox2. Retention rates in the wetlands ranged from 0.25 to 2.74gN/m(2)/day in Ox1 and 0.29 to 1.94gN/m(2)/day in Ox2. Percent retention of the NO3--N load that entered the wetlands during the storm events ranged from 64 to 87% and 23 to 26%, in Ox1 and Ox2, respectively. During all four storm events, Ox1 and Ox2 were a small net source of dissolved PO43- to the adjacent stream (i.e., more P exited than entered the wetland), releasing P at a rate of 0.23-20.83mgP/m(2)/day and 3.43-24.84mgP/m(2)/day, respectively. N and P removal efficiency of the oxbows were regulated by hydrologic connectivity, hydraulic loading, and retention time. Incidental oxbow wetlands have potential to receive urban stream and storm flow and to be significant N sinks, but they may be sources of P in urban watersheds.
C1 [Harrison, Melanie D.] Univ Maryland Baltimore Cty, Dept Marine Estuarine & Environm Sci, Baltimore, MD 21250 USA.
[Miller, Andrew J.] Univ Maryland Baltimore Cty, Dept Geog & Environm Syst, Baltimore, MD 21250 USA.
[Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12454 USA.
[Mayer, Paul M.] US EPA, Ecol Effects Branch, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Kaushal, Sujay S.] Univ Maryland, Dept Geol, College Pk, MD 20740 USA.
[Kaushal, Sujay S.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
RP Harrison, MD (reprint author), NOAA, Southwest Reg Protected Resources Div, 777 Sonoma Ave, Santa Rosa, CA 95404 USA.
EM melanie.harrison@noaa.gov
OI Mayer, Paul/0000-0002-8550-1386
FU U.S. Environmental Protection Agency [CR829676]; U.S. National Science
Foundation (NSF) Long-Term Ecological Research program [DEB-0423476];
NSF Integrative Graduate Education and Research Traineeship Program
[0549469]; Maryland Sea Grant [SA7528085-U]; NSF Division of Biological
Infrastructure [DBI 06-40300]; NOAA Educational Partnership Graduate
Science Program (GSP)
FX This research was supported by grants from the U.S. Environmental
Protection Agency (CR829676), the U.S. National Science Foundation (NSF)
Long-Term Ecological Research program (DEB-0423476), the NSF Integrative
Graduate Education and Research Traineeship Program (0549469), Maryland
Sea Grant (SA7528085-U), the NSF Division of Biological Infrastructure
(DBI 06-40300), and the NOAA Educational Partnership Graduate Science
Program (GSP). We thank Dan Dillon, Dave Lewis, Lisa Martel, Daniel
Jones, Gwendolyn Sivirichi, Melissa Grese, Tamara Newcomer, Emma Noonan,
Yvette Williams, and Charlene Gavette for assistance with field and
laboratory work, and Christopher Swan for thoughtful comments and review
of the manuscript. This manuscript has been subjected to USEPA review,
but does not necessarily reflect the views of any of the funding
agencies, and no official endorsement should be inferred.
NR 79
TC 6
Z9 6
U1 10
U2 55
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1365
EP 1382
DI 10.1111/jawr.12193
PG 18
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900001
ER
PT J
AU Greathouse, EA
Compton, JE
Van Sickle, J
AF Greathouse, Effie A.
Compton, Jana E.
Van Sickle, John
TI LINKING LANDSCAPE CHARACTERISTICS AND HIGH STREAM NITROGEN IN THE OREGON
COAST RANGE: RED ALDER COMPLICATES USE OF NUTRIENT CRITERIA
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE Pacific Northwest; biogeochemistry; nutrients; rivers; streams; forests;
environmental regulations
ID CONTERMINOUS UNITED-STATES; WATER-QUALITY; PACIFIC-NORTHWEST; LAND-USE;
FORESTED WATERSHEDS; DIATOM ASSEMBLAGES; TILLAMOOK BAY; YAQUINA BAY;
DATA SETS; INDICATORS
AB Red alder (Alnus rubra), a nitrogen(N)-fixing deciduous broadleaf tree, can strongly influence N concentrations in western Oregon and Washington. We compiled a database of stream N and GIS-derived landscape characteristics in order to examine geographic variation in N across the Oregon Coast Range. Basal area of alder, expressed as a percent of watershed area, accounted for 37% and 38% of the variation in summer nitrate and total N (TN) concentrations, respectively. Relationships between alder and nitrate were strongest in winter when streamflow and landscape connections are highest. Distance to the coast and latitude, potential surrogates for sea salt inputs, and watershed area were also related to nitrate concentrations in an all-subsets regression analysis, which accounted for 46% of the variation in summer nitrate concentrations. The model with the lowest Akaike's Information Criterion did not include developed or agricultural land cover, probably because few watersheds in our database had substantial levels of these land cover classes. Our results provide evidence, at a regional scale, that background sources and processes cause many Coast Range streams to exceed proposed nutrient criteria, and that the prevalence of a single tree species (N-fixing red alder) exerts a dominant control over stream N concentrations across this region.
C1 [Greathouse, Effie A.; Compton, Jana E.; Van Sickle, John] US EPA, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Greathouse, EA (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, 321 Richardson Hall, Corvallis, OR 97331 USA.
EM effieg@gmail.com
FU U.S. Environmental Protection Agency (USEPA)
FX Thanks to Patti Haggerty and Tad Larsen for essential assistance with
GIS analyses. Many individuals generously shared data and provided
assistance in understanding databases and dataset coding, including:
Alan Herlihy, Robbins Church, Kathy Motter, Rachael Gruen (USEPA data);
Sigrid Schwind, Allen Hamel, Richard Myzak, Steve Mrazik, Leslie
Merrick, Aaron Borisenko, Raeann Haynes, Chris Redman (OR DEQ data);
Linda Ashkenas, Sherri Johnson, Kirsten Gallo (Trask Watershed study and
USFS data); Diana Walker, Paul Measeles, Janet Ohmann (GIS layers). This
work was funded by the U.S. Environmental Protection Agency (USEPA) and
approved for publication after USEPA review. Approval does not signify
that the contents reflect the views of the agency, and the mention of
trade names or commercial products does not imply endorsement.
NR 84
TC 0
Z9 0
U1 2
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1383
EP 1400
DI 10.1111/jawr.12194
PG 18
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900002
ER
PT J
AU Jiang, Y
Frankenberger, JR
Sui, YH
Bowling, LC
AF Jiang, Yan
Frankenberger, Jane R.
Sui, Yinghui
Bowling, Laura C.
TI ESTIMATION OF NONPOINT SOURCE NITRATE CONCENTRATIONS IN INDIANA RIVERS
BASED ON AGRICULTURAL DRAINAGE IN THE WATERSHED
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE agricultural nitrate; nonpoint source; tile drainage; regression model
ID GULF-OF-MEXICO; MISSISSIPPI RIVER; UNITED-STATES; SAMPLING FREQUENCY;
SUBSURFACE DRAINS; NITROGEN LOADS; NUTRIENT LOADS; HYPOXIA; BASIN;
UNCERTAINTIES
AB Subsurface tile-drained agricultural fields are known to be important contributors to nitrate in surface water in the Midwest, but the effect of these fields on nitrate at the watershed scale is difficult to quantify. Data for 25 watersheds monitored by the Indiana Department of Environmental Management and located near a U.S. Geological Survey stream gage were used to investigate the relationship between flow-weighted mean concentration (FWMC) of nitrate-N and the subsurface tile-drained area (DA) of the watershed. The tile DA was estimated from soil drainage class, land use, and slope. Nitrate loads from point sources were estimated based on reported flows of major permitted facilities with mean nitrate-N concentrations from published sources. Linear regression models exhibited a statistically significant relationship between annual/monthly nonpoint source (NPS) nitrate-N and DA percentage. The annual model explained 71% of the variation in FWMC of nitrate-N. The annual and monthly models were tested in 10 additional watersheds, most with absolute errors within 1mg/l in the predicted FWMC. These models can be used to estimate NPS nitrate for unmonitored watersheds in similar areas, especially for drained agricultural areas where model performance was strongest, and to predict the nitrate reduction when various tile drainage management techniques are employed.
C1 [Jiang, Yan] US EPA, Las Vegas, NV 89118 USA.
[Frankenberger, Jane R.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47904 USA.
[Sui, Yinghui] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47904 USA.
[Bowling, Laura C.] Purdue Univ, Dept Agron, W Lafayette, IN 47904 USA.
RP Jiang, Y (reprint author), US EPA, 944 Harmon Ave, Las Vegas, NV 89118 USA.
EM enaj1125@gmail.com
RI Bowling, Laura/B-6963-2013
OI Bowling, Laura/0000-0002-1439-3154
NR 55
TC 3
Z9 3
U1 1
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1501
EP 1514
DI 10.1111/jawr.12216
PG 14
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900011
ER
PT J
AU Jessup, BK
Kaufmann, PR
John, F
Guevara, LS
Joseph, S
AF Jessup, Benjamin K.
Kaufmann, Philip R.
John, Forrest
Guevara, Lynette S.
Joseph, Seva
TI BEDDED SEDIMENT CONDITIONS AND MACROINVERTEBRATE RESPONSES IN NEW MEXICO
STREAMS: A FIRST STEP IN ESTABLISHING SEDIMENT CRITERIA
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE environmental impacts; Relative Bed Stability; channel morphology;
sediment; invertebrates
ID WATER-QUALITY CRITERIA; MOUNTAIN STREAMS; FINE SEDIMENT; UNITED-STATES;
BIOTIC INDEX; THRESHOLDS; REGRESSION; STABILITY; ROUGHNESS
AB Excess fine sediments in streambeds are among the most pervasive causes of degradation in streams of the United States. Simple criteria for acceptable streambed fines are elusive because streambed fines and biotic tolerances vary widely in the absence of human disturbances. In response to the need for sediment benchmarks that are protective of minimum aquatic life uses under the Clean Water Act, we undertook a case study using surveys of sediment, physical habitat, and macroinvertebrates from New Mexico streams. Our approach uses weight of evidence to develop suggested benchmarks for protective levels of surficial bedded sediments <0.06mm (silt and finer) and <2.0mm (sand and finer). We grouped streams into three ecoregions that were expected to produce similar naturally occurring streambed textures and patterns of response to human disturbances. Within ecoregions, we employed stressor response models to estimate fine sediment percentages and bed stability that are tolerated by resident macroinvertebrates. We then compared individual stream sediment data with distributions among least-disturbed reference sites to determine deviation from natural conditions, accounting for natural variability across ecoregion, gradient, and drainage area. This approach for developing benchmark values could be applied more widely to provide a solid basis for developing bedded sediment criteria and other protective management strategies in other regions.
C1 [Jessup, Benjamin K.] Tetra Tech Inc, Ctr Ecol Sci, Montpelier, VT 05602 USA.
[Kaufmann, Philip R.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab ORD, Corvallis, OR 97333 USA.
[John, Forrest] US EPA, Dallas, TX 75202 USA.
[Guevara, Lynette S.; Joseph, Seva] Surface Water Qual Bur, New Mexico Environm Dept, Santa Fe, NM 87505 USA.
RP Jessup, BK (reprint author), Tetra Tech Inc, Ctr Ecol Sci, 73 Main St,Suite 38, Montpelier, VT 05602 USA.
EM benjamin.jessup@tetratech.com
FU U.S. Environmental Protection Agency [EP-C-08-004]
FX Funding for this project was provided by the U.S. Environmental
Protection Agency through contract EP-C-08-004 to Tetra Tech, Inc. Field
survey data were provided by the U.S. Environmental Protection Agency
Wadeable Streams Assessment and Western Environmental Monitoring and
Assessment Programs. James Hogan of the New Mexico Environment
Department provided insightful suggestions and interpretations
throughout the analyses. Angel Kosfisher of EPA Region 6 conducted GIS
analyses. Erik Leppo of Tetra Tech helped in data management and
analysis. Revisions suggested by Bob Ozretich, John Faustini, Lil
Herger, and Larry Willis improved the manuscript, as did the comments
provided by the associate editor and two anonymous reviewers. This paper
was subjected to peer and administrative review at the National Health
and Environmental Effects Research Laboratory's Western Ecology Division
and approved for publication. Approval does not signify that the
contents reflect the views of the USEPA, nor does mention of trade names
or commercial products constitute endorsement or recommendation for use.
NR 45
TC 1
Z9 1
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1558
EP 1574
DI 10.1111/jawr.12224
PG 17
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900015
ER
PT J
AU Tollefsen, KE
Scholz, S
Cronin, MT
Edwards, SW
de Knecht, J
Crofton, K
Garcia-Reyero, N
Hartung, T
Worth, A
Patlewicz, G
AF Tollefsen, Knut Erik
Scholz, Stefan
Cronin, Mark T.
Edwards, Stephen W.
de Knecht, Joop
Crofton, Kevin
Garcia-Reyero, Natalia
Hartung, Thomas
Worth, Andrew
Patlewicz, Grace
TI Applying Adverse Outcome Pathways (AOPs) to support Integrated
Approaches to Testing and Assessment (IATA)
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Adverse Outcome Pathway (AOP); Integrated Approaches to Testing and
Assessment (IATA); (Q)SAR; Read-across; High throughput screening (HTS);
High content screening (HCS); Cross species extrapolation
ID SCREENING CONTACT ALLERGENS; ALKYLATED NON-PHENOLICS; IN-VITRO;
RISK-ASSESSMENT; CELL-LINE; SKIN SENSITIZATION; ACETYLCHOLINESTERASE
INHIBITION; DISRUPTING CHEMICALS; CONCEPTUAL-FRAMEWORK; PEPTIDE
REACTIVITY
AB Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled "Advancing AOPs for Integrated Toxicology and Regulatory Applications" with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Tollefsen, Knut Erik] Norwegian Inst Water Res NIVA, N-0349 Oslo, Norway.
[Scholz, Stefan] UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, D-04318 Leipzig, Germany.
[Cronin, Mark T.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England.
[Edwards, Stephen W.; Crofton, Kevin] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[de Knecht, Joop] Org Econ Cooperat & Dev, Environm Directorate, Environm Hlth & Safety Div, F-75775 Paris 16, France.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Hartung, Thomas] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA.
[Worth, Andrew] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, Syst Toxicol Unit, Ispra, Varese, Italy.
[Patlewicz, Grace] DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19711 USA.
RP Patlewicz, G (reprint author), DuPont Haskell Global Ctr, Newark, DE 19711 USA.
EM knut.erik.tollefsen@niva.no; stefan.scholz@ufz.de;
M.T.Cronin@ljmu.ac.uk; Edwards.Stephen@epa.gov; Joop.DEKNECHT@oecd.org;
Crofton.Kevin@epa.gov; natalia@icnanotox.org; thartung@jhsph.edu;
Andrew.WORTH@ec.europa.eu; patlewig@hotmail.com
RI Scholz, Stefan/B-7776-2014; Crofton, Kevin/J-4798-2015;
OI Scholz, Stefan/0000-0002-6990-4716; Crofton, Kevin/0000-0003-1749-9971;
Patlewicz, Grace/0000-0003-3863-9689
FU American Chemistry Council (ACC); BioDetection Systems; European Centre
for Ecotoxicology and Toxicology of Chemicals (ECETOC); Environment
Canada; European Commission Directorate General Joint Research Centre;
Human Toxicology Project Consortium; International Life Sciences
Institute - Health and Environmental Science Institute; Research Council
of Norway [221455]; Society for Environmental Toxicology and Chemistry
(SETAC); US Army Engineer Research and Development Center; U.S.
Environmental Protection Agency
FX The content of this paper is the result of an international expert
workshop on Advancing Adverse Outcome Pathways (AOP5) for Integrated
Toxicology and Regulatory Applications. Support for the workshop was
provided by the American Chemistry Council (ACC), BioDetection Systems,
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC),
Environment Canada, European Commission Directorate General Joint
Research Centre, Human Toxicology Project Consortium, International Life
Sciences Institute - Health and Environmental Science Institute, The
Research Council of Norway (Grant No. 221455), Society for Environmental
Toxicology and Chemistry (SETAC), US Army Engineer Research and
Development Center, and the U.S. Environmental Protection Agency. The
authors acknowledge the workshop organizing committee, and all workshop
participants for both plenary and informal discussions that influenced
the content presented here. The views expressed are those of the
authors, and do not necessarily represent the views of the organizations
the authors are affiliated with or the sponsors. Mention of trade names
does not imply endorsement by any of the author organizations or
sponsors.; The participation of Tatiana Netzeva and Alberto Martin
Aparicio from the European Chemicals Agency (ECHA) in the discussions of
the workshop is also acknowledged. The views expressed at the workshop
represented the personal opinion of the experts as individual scientists
and regulatory professionals and do not constitute an official position
of ECHA.; The opinions expressed and arguments employed herein are those
of the authors and do not necessarily reflect the official views of the
OECD or the governments of its member countries.; The information in
this document has been funded wholly (or in part) by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory (NHEERL)
and approved for publication. Approval does not signify that the
contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 113
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Z9 52
U1 11
U2 49
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD DEC
PY 2014
VL 70
IS 3
BP 629
EP 640
DI 10.1016/j.yrtph.2014.09.009
PG 12
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA AU7ZO
UT WOS:000345816900007
PM 25261300
ER
PT J
AU Crump, KS
Bussard, DA
Chen, C
Jinot, J
AF Crump, Kenny S.
Bussard, D. A.
Chen, C.
Jinot, J.
TI The "bottom-up" approach does not necessarily bound low-dose risk
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Letter
C1 [Bussard, D. A.; Chen, C.; Jinot, J.] US EPA, Washington, DC 20460 USA.
RP Crump, KS (reprint author), 2220 S Vienna St, Ruston, LA 71270 USA.
EM KennyCrump@email.com; Bussard.David@epa.gov; chaochen25@comcast.net;
Jinot.Jennifer@epa.gov
NR 2
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD DEC
PY 2014
VL 70
IS 3
BP 735
EP 736
DI 10.1016/j.yrtph.2014.10.008
PG 2
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA AU7ZO
UT WOS:000345816900020
PM 25455229
ER
PT J
AU Foley, KM
Napelenok, SL
Jang, C
Phillips, S
Hubbell, BJ
Fulcher, CM
AF Foley, Kristen M.
Napelenok, Sergey L.
Jang, Carey
Phillips, Sharon
Hubbell, Bryan J.
Fulcher, Charles M.
TI Two reduced form air quality modeling techniques for rapidly calculating
pollutant mitigation potential across many sources, locations and
precursor emission types
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE CMAQ-DDM; Response surface model; Emission controls; PM2.5; Ozone
ID SENSITIVITY-ANALYSIS; NONLINEAR RESPONSE; OZONE; EXPOSURE; SYSTEM;
IMPACT; CHINA
AB Due to the computational cost of running regional-scale numerical air quality models, reduced form models (RFM) have been proposed as computationally efficient simulation tools for characterizing the pollutant response to many different types of emission reductions. The U.S. Environmental Protection Agency has developed two types of reduced form models based upon simulations of the Community Multiscale Air Quality (CMAQ) modeling system. One is based on statistical response surface modeling (RSM) techniques using a multidimensional kriging approach to approximate the nonlinear chemical and physical processes. The second approach is based on using sensitivity coefficients estimated with the Decoupled Direct Method in 3 dimensions (CMAQ-DDM-3D) in a Taylor series approximation for the nonlinear response of the pollutant concentrations to changes in emissions from specific sectors and locations. Both types of reduced form models are used to estimate the changes in O-3 and PM2.5 across space associated with emission reductions of NOx and SO2 from power plants and other sectors in the eastern United States. This study provides a direct comparison of the RSM- and DDM-3D-based tools in terms of: computational cost, model performance against brute force runs, and model response to changes in emission inputs. For O-3, the DDM-3D RFM had slightly better performance on average for low to moderate emission cuts compared to the kriging-based RSM, but over-predicted O-3 disbenefits from cuts to mobile source NOx in very urban areas. The RSM approach required more up-front computational cost and produced some spurious O-3 increases in response to reductions in power plant emissions. However the RSM provided more accurate predictions for PM2.5 and for predictions of very large emission cuts (e.g. -60 to -90%). This comparison indicates that there are some important differences in the output of the two approaches that should be taken under consideration when interpreting results for a given application. Published by Elsevier Ltd.
C1 [Foley, Kristen M.; Napelenok, Sergey L.; Jang, Carey; Phillips, Sharon; Hubbell, Bryan J.; Fulcher, Charles M.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Foley, KM (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM foley.kristen@epa.gov
OI Hubbell, Bryan/0000-0002-7963-3438
NR 17
TC 3
Z9 4
U1 3
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 283
EP 289
DI 10.1016/j.atmosenv.2014.08.046
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000030
ER
PT J
AU Nallathamby, PD
Lewandowski, M
Jaoui, M
Offenberg, JH
Kleindienst, TE
Rubitschun, C
Surratt, JD
Usenko, S
Sheesley, RJ
AF Nallathamby, Punith Dev
Lewandowski, Michael
Jaoui, Mohammed
Offenberg, John H.
Kleindienst, Tadeusz E.
Rubitschun, Caitlin
Surratt, Jason D.
Usenko, Sascha
Sheesley, Rebecca J.
TI Qualitative and quantitative assessment of unresolved complex mixture in
PM2.5 of Bakersfield, CA
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Southern California; Semi-volatile organic carbon; Traffic emissions;
PM2.5
ID SECONDARY ORGANIC AEROSOL; RESOLUTION GAS-CHROMATOGRAPHY; AIR-POLLUTION
SOURCES; N-ALKANES; UNITED-STATES; OIL-SPILL; EMISSIONS; HYDROCARBONS;
CALIFORNIA; SEDIMENTS
AB The 2010 CalNex (California Nexus) field experiment offered an opportunity for detailed characterization of atmospheric particulate carbon composition and sources in Bakersfield, CA. In the current study, the authors describe and employ a new protocol for reporting unresolved complex mixture (UCM) in over 30 daily samples. The Bakersfield, CA site has significant contribution from UCM, 2.9 +/- 2.2% of the daily OC, which makes it an ideal first application. The new protocol reports two UCM peaks for Bakersfield with unique mean vapor pressure, retention time, mass spectra and daily ambient concentration trends. The first UCM peak, UCM-A, was comprised of semi-volatile compounds including alkanes, alkenes, and allcynes, with a mean vapor pressure of 2E-04 Tort and medium to heavy-duty diesel exhaust as a likely source. The second UCM peak, UCM-B, was comprised of linear, branched, and cyclic alkanes, with a mean vapor pressure of 1E-08 Torr. UCM-B had strong similarities to UCM in the NIST Standard Reference Material 1649b (urban dust) and to previously reported, detailed UCM for a representative Bakersfield sample, with possible sources including: motor vehicle exhaust, agricultural activities, and construction activities. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Nallathamby, Punith Dev; Usenko, Sascha; Sheesley, Rebecca J.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA.
[Lewandowski, Michael; Offenberg, John H.; Kleindienst, Tadeusz E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Jaoui, Mohammed] Alion Sci & Technol, Res Triangle Pk, NC USA.
[Rubitschun, Caitlin; Surratt, Jason D.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC USA.
RP Sheesley, RJ (reprint author), Baylor Univ, Dept Environm Sci, OBP 97266, Waco, TX 76798 USA.
EM rebecca_sheesley@baylor.edu
RI Surratt, Jason/D-3611-2009; Offenberg, John/C-3787-2009; Sheesley,
Rebecca/I-6655-2015; Guenat, Heather/H-6528-2014; Usenko,
Sascha/N-8730-2015;
OI Surratt, Jason/0000-0002-6833-1450; Offenberg, John/0000-0002-0213-4024;
Sheesley, Rebecca/0000-0002-8187-0571
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-D-10-070]; Baylor University; University Research
Committee; C. Gus Glasscock, Jr. Endowed Fund for Excellence in
Environmental Sciences
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and collaborated in the research described here
under Contract EP-D-10-070 to Alion Science and Technology. The
manuscript has been subjected to external peer review and has been
cleared for publication. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. This study
was supported in part by Baylor University funds including the
University Research Committee and the C. Gus Glasscock, Jr. Endowed Fund
for Excellence in Environmental Sciences.
NR 36
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U1 2
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 368
EP 375
DI 10.1016/j.atmosenv.2014.09.006
PG 8
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000039
ER
PT J
AU Napelenok, SL
Vedantham, R
Bhave, PV
Pouliot, GA
Kwok, RHF
AF Napelenok, Sergey L.
Vedantham, Ram
Bhave, Prakash V.
Pouliot, George A.
Kwok, Roger H. F.
TI Source-receptor reconciliation of fine-particulate emissions from
residential wood combustion in the southeastern United States
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Particulate matter; Residential wood combustion; Carbon; Air quality
model; Source apportionment
ID CMAQ MODELING SYSTEM; PARTICLE EMISSIONS; AIR-QUALITY; PM2.5;
COMPONENTS; HEALTH; IMPACT; CARBON; SMOKE; MODIS
AB An extensive collection of speciated PM2.5 measurements including organic tracers permitted a detailed examination of the emissions from residential wood combustion (RWC) in the southeastern United States over an entire year (2007). The Community Multiscale Air Quality model-based Integrated Source Apportionment Method (CMAQ-ISAM) was used in combination with the U.S. National Emissions Inventory (NEI) to compute source contributions from ten categories of biomass combustion, including RWC. A novel application of the receptor-based statistical model, Unmix, was used to subdivide the observed concentrations of levoglucosan, a unique tracer of biomass combustion. Using the CMAQ-ISAM and Unmix models together, we find that the emission-based RWC contribution to ambient carbonaceous PM2.5 predicted by the model is approximately a factor of two lower than indicated by observations. Recommendations for improving the temporal allocation of the emissions are proposed and tested to show a potential improvement in model RWC predictions, quantified by approximately 15% less bias. Further improvements in the sector predictions could be achieved with a survey-based analysis of detailed RWC emission patterns. Published by Elsevier Ltd.
C1 [Napelenok, Sergey L.; Vedantham, Ram; Bhave, Prakash V.; Pouliot, George A.; Kwok, Roger H. F.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Napelenok, SL (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM napelenok.sergey@epa.gov
NR 23
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 454
EP 460
DI 10.1016/j.atmosenv.2014.09.021
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000049
ER
PT J
AU Christensen, K
Sobus, J
Phillips, M
Blessinger, T
Lorber, M
Tan, YM
AF Christensen, Krista
Sobus, Jon
Phillips, Martin
Blessinger, Todd
Lorber, Matthew
Tan, Yu-Mei
TI Changes in epidemiologic associations with different exposure metrics: A
case study of phthalate exposure associations with body mass index and
waist circumference
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Exposure metric; Phthalates; BMI; WC; Bias
ID HUMAN HEALTH-RISKS; DI(2-ETHYLHEXYL)PHTHALATE DEHP; BISPHENOL-A;
ENVIRONMENTAL CONTAMINANTS; URINARY CONCENTRATIONS; LIPID ADJUSTMENT;
METABOLITES; SAMPLES; VARIABILITY; CHILDREN
AB The use of human biomonitoring data to characterize exposure to environmental contaminants in epidemiology studies has expanded greatly in recent years. Substantial variability in effect measures may arise when using different exposure metrics for a given contaminant, and it is often not clear which metric is the best surrogate for the 'causal' or 'true' exposure. Here we evaluated variability and potential bias in epidemiologic associations resulting from the use of different phthalate exposure metrics in the 2009-2010 National Health and Nutrition Examination Survey (NHANES). We examined associations between urinary phthalate metabolites and the outcomes of body mass index (BMI) and waist circumference (WC). We examined each of the following NHANES-derived exposure metrics for metabolites of individual phthalates: molar excretion rate (nmol/min), molar amount (nmol), molar concentration (nmol/mL, with and without additional model adjustment for creatinine), creatinine corrected molar concentration (nmol/g creatinine), and reconstructed daily phthalate intake (nmol/kg/day). In order to investigate potential biasing effect of each metric, we first assumed that daily intake of the parent phthalate is the causal exposure. We then constructed a simulated population based on the 2009-2010 NHANES, and randomly assigned each individual a di-2-ethylhexyl phthalate (DEHP) intake dose based on a published distribution, but independent of any other factor. Accordingly, all associations between these randomly assigned intake doses and individuals' BMI and WC should be null. Next, demographic data in the NHANES were incorporated into a pharmacokinetic model to predict urinary molar excretions of five DEHP metabolites based on the randomly assigned DEHP intake. The predicted molar excretions were then used to calculate the same exposure metrics listed above. Three exposure metrics (randomly generated intake, excretion rate, urine concentration) showed no significant associations with BMI, which supports the null hypothesis stated above. In contrast, metrics adjusted for creatinine showed a significant negative correlation, and reconstructed daily intake showed a significant positive correlation, indicating the introduction of bias away from the true (i.e., null) association. Interestingly, trends in the simulation analysis were similar to those seen in the observed NHANES data. Our findings show that, at least in this example case, the choice of exposure metric can introduce significant bias of varying magnitude and direction into the calculation of epidemiologic associations. Published by Elsevier Ltd.
C1 [Christensen, Krista; Blessinger, Todd; Lorber, Matthew] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Sobus, Jon; Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Phillips, Martin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Duluth, MN USA.
RP Christensen, K (reprint author), Bur Environm & Occupat Hlth, Wisconsin Div Publ Hlth, 1 W Wilson St,Rm 150, Madison, WI 53701 USA.
OI Phillips, Martin/0000-0002-6282-529X
NR 42
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 66
EP 76
DI 10.1016/j.envint.2014.07.010
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700008
PM 25090576
ER
PT J
AU Jhun, I
Fann, N
Zanobetti, A
Hubbell, B
AF Jhun, Iny
Fann, Neal
Zanobetti, Antonella
Hubbell, Bryan
TI Effect modification of ozone-related mortality risks by temperature in
97 US cities
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Ozone; Temperature; Mortality; Effect modification; Air conditioning
ID AIR-POLLUTION; NATIONAL MORBIDITY; PARTICULATE MATTER; TIME-SERIES;
NMMAPS DATA; COMMUNITIES; METAANALYSIS; POLLUTANTS; EXPOSURE; MODIFY
AB Many time-series studies have characterized the relationship between short-term ozone exposure and adverse health outcomes, controlling for temperature as a confounder. Temperature may also modify ozone effects, though this has been largely under-investigated. In this study, we explored whether temperature modifies the effect of short-term ozone exposure on mortality. We used the database developed for the National Morbidity and Mortality Air Pollution Study to estimate ozone mortality risks in 97 US cities in May through September, 1987-2000. We treated temperature as a confounder as well as an effect modifier by estimating risks at low, moderate, and high temperature categories. When temperature was treated as a confounder, a 10-ppb increase in daily 24-h ozone was associated with a 0.47% (95% CI: 0.19%-0.76%) increase in mortality. When we assessed effect modification by temperature, the interaction between ozone and temperature was not statistically significant However, there was a U-shaped pattern in mortality risk, which was greater at the low (<25th percentile) and high (>75th percentile) temperature levels than moderate temperature levels. At the high temperature category, a 10% increase in AC prevalence mitigated mortality risk associated with 10-ppb of ozone exposure by -0.18% (95% CI: -0.35%, -0.02%). Furthermore, ozone mortality risk in the high temperature category increased as we restricted our analyses to hotter days. On days where temperatures exceeded the 75th, 90th, and 95th percentile temperatures, a 10-ppb increase in ozone was associated with a 0.65% (95% CI: 0.20%-1.09%), 0.83% (95% CI: 0.17%-1.48%), and 135% (95% CI: 0.44%-2.27%) increase in mortality, respectively. These results suggested that high temperatures may exacerbate physiological responses to short-term ozone exposure. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jhun, Iny; Zanobetti, Antonella] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Fann, Neal; Hubbell, Bryan] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Jhun, I (reprint author), 401 Pk Dr,Landmark 4 West,Rm 412 J, Boston, MA 02215 USA.
EM iny@mail.harvard.edu
OI Fann, Neal/0000-0002-6724-8575; Hubbell, Bryan/0000-0002-7963-3438
FU EPA's National Network for Environmental Management Studies fellowship;
Harvard School of Public Health scholarship
FX This work was made possible by the EPA's National Network for
Environmental Management Studies fellowship and the Harvard School of
Public Health scholarship. We thank the journal reviewers for their
suggestions on the AC prevalence analyses.
NR 29
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 128
EP 134
DI 10.1016/j.envint.2014.07.009
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700015
PM 25113626
ER
PT J
AU LaKind, JS
Sobus, JR
Goodman, M
Barr, DB
Furst, P
Albertini, RJ
Arbuckle, TE
Schoeters, G
Tan, YM
Teeguarden, J
Tornero-Velez, R
Weisel, CP
AF LaKind, Judy S.
Sobus, Jon R.
Goodman, Michael
Barr, Dana Boyd
Fuerst, Peter
Albertini, Richard J.
Arbuckle, Tye E.
Schoeters, Greet
Tan, Yu-Mei
Teeguarden, Justin
Tornero-Velez, Rogelio
Weisel, Clifford P.
TI A proposal for assessing study quality: Biomonitoring, Environmental
Epidemiology, and Short-lived Chemicals (BEES-C) instrument
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE BEES-C; Biomonitoring; Ubiquitous chemicals; Short physiologic
half-life; Evaluation instrument; Environmental epidemiology
ID NUTRITION EXAMINATION SURVEY; 24-H URINE SAMPLES; BISPHENOL-A;
NONDIFFERENTIAL MISCLASSIFICATION; TEMPORAL VARIABILITY; UNITED-STATES;
MOLECULAR EPIDEMIOLOGY; PYRETHROID METABOLITES; HYPOTHESIS GENERATION;
PHTHALATE METABOLITES
AB The quality of exposure assessment is a major determinant of the overall quality of any environmental epidemiology study. The use of biomonitoring as a tool for assessing exposure to ubiquitous chemicals with short physiologic half-lives began relatively recently. These chemicals present several challenges, including their presence in analytical laboratories and sampling equipment, difficulty in establishing temporal order in cross-sectional studies, short- and long-term variability in exposures and biomarker concentrations, and a paucity of information on the number of measurements required for proper exposure classification. To date, the scientific community has not developed a set of systematic guidelines for designing, implementing and interpreting studies of short-lived chemicals that use biomonitoring as,the exposure metric or for evaluating the quality of this type of research for WOE assessments or for peer review of grants or publications. We describe key issues that affect epidemiology studies using biomonitoring data on short-lived chemicals and propose a systematic instrument - the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument - for evaluating the quality of research proposals and studies that incorporate biomonitoring data on short-lived chemicals. Quality criteria for three areas considered fundamental to the evaluation of epidemiology studies that include biological measurements of short-lived chemicals are described: 1) biomarker selection and measurement, 2) study design and execution, and 3) general epidemiological study design considerations. We recognize that the development of an evaluative tool such as BEES-C is neither simple nor non-controversial. We hope and anticipate that the instrument will initiate further discussion/debate on this topic. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [LaKind, Judy S.] LaKind Associates LLC, Catonsville, MD 21228 USA.
[LaKind, Judy S.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, College Pk, MD USA.
[LaKind, Judy S.] Penn State Univ, Dept Pediat, Coll Med, Milton S Hershey Med Ctr, University Pk, PA 16802 USA.
[Sobus, Jon R.; Tan, Yu-Mei; Tornero-Velez, Rogelio] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA.
[Goodman, Michael] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
[Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA 30322 USA.
[Fuerst, Peter] Munsterland Emscher Lippe CVUA MEL, Chem & Vet Analyt Inst, D-48151 Munster, Germany.
[Albertini, Richard J.] Univ Vermont, Coll Med, Underhill Ctr, VT 05490 USA.
[Arbuckle, Tye E.] Hlth Canada, Populat Studies Div, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0K9, Canada.
[Schoeters, Greet] VITO, Environm Risk & Hlth Unit, B-2400 Mol, Belgium.
[Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium.
[Teeguarden, Justin] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Weisel, Clifford P.] UMDNJ, Environm & Occupat Hlth Sci Inst, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
RP LaKind, JS (reprint author), LaKind Associates LLC, 106 Oakdale Ave, Catonsville, MD 21228 USA.
EM lakindassoc@gmail.com; Sobus.Jon@epa.gov; mgoodm2@emory.edu;
dbbarr@emory.edu; Peter.Fuerst@cvua-mel.de; Ralbert315@aol.com;
Tye.Arbuckle@hc-sc.gc.ca; greet.schoeters@vito.be; Tan.Cecilia@epa.gov;
jt@pnnl.gov; Tornero-Velez.Rogelio@epa.gov; weisel@eohsi.rutgers.edu
OI Teeguarden, Justin/0000-0003-3817-4391
FU Polycarbonate/BPA Global Group of the American Chemistry Council (ACC)
FX The Workshop was sponsored by Polycarbonate/BPA Global Group of the
American Chemistry Council (ACC). ACC was not involved in the design,
management, or development of the Workshop or in the preparation or
approval of the manuscript Workshop participants or their affiliated
organizations received an honorarium (except JSL, ES, GS, JS, JT, Y-MT,
RT-V, TA) and travel support (except TA, Y-MT, DB, ES). JSL received
support for Workshop development and facilitation; JSL consults to
governmental and private sectors. MG regularly serves as a consultant
for the government and for the private sector. No other competing
interests are declared.
NR 122
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U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 195
EP 207
DI 10.1016/j.envint.2014.07.011
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700023
PM 25137624
ER
PT J
AU Xue, JP
Zartarian, V
Tornero-Velez, R
Tulve, NS
AF Xue, Jianping
Zartarian, Valerie
Tornero-Velez, Rogelio
Tulve, Nicolle S.
TI EPA's SHEDS-multimedia model: Children's cumulative pyrethroid exposure
estimates and evaluation against NHANES biomarker data
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE SHEDS-Multimedia; Pyrethroids; Cumulative; Exposure; Dose; Model
ID PRESCHOOL-CHILDREN; DERMAL ABSORPTION; INSECTICIDES; PERMETHRIN;
CYPERMETHRIN; METABOLITES; POPULATION; PESTICIDES; PLAYSETS; DIETARY
AB The U.S. EPA's SHEDS-Multimedia model was applied to enhance the understanding of children's exposures and doses to multiple pyrethroid pesticides, including major contributing chemicals and pathways. This paper presents combined dietary and residential exposure estimates and cumulative doses for seven commonly used pyrethroids, and comparisons of model evaluation results with NHANES biomarker data for 3-PBA and DCCA metabolites. Model input distributions were fit to publicly available pesticide usage survey data, NHANES, and other studies, then SHEDS-Multimedia was applied to estimate total pyrethroid exposures and doses for 35 year olds for one year variability simulations. For dose estimations we used a pharmacokinetic model and two approaches for simulating dermal absorption. SHEDS-Multimedia predictions compared well to NHANES biomarker data: ratios of 3-PBA observed data to SHEDS-Multimedia modeled results were 0.88, 0.51, 0.54 and 1.02 for mean, median, 95th, and 99th percentiles, respectively; for DCCA, the ratios were 0.82, 0.53, 0.56, and 0.94. Modeled time-averaged cumulative absorbed dose of the seven pyrethroids was 3.1 nmol/day (versus 8.4 nmol/day for adults) in the general population (residential pyrethroid use and non-use homes) and 6.7 nmol/day (versus 10.5 nmol/day for adults) in the simulated residential pyrethroid use population. For the general population, contributions to modeled cumulative dose by chemical were permethrin (60%), cypermethrin (22%), and cyfluthrin (16%); for residential use homes, contributions were cypermethrin (49%), permethrin (29%), and cyfiuthrin (17%). The primary exposure route for 3-5 year olds in the simulated residential use population was non-dietary ingestion exposure; whereas for the simulated general population, dietary exposure was the primary exposure route. Below the 95th percentile, the major exposure pathway was dietary for the general population; non-dietary ingestion was the major pathway starting below the 70th percentile for the residential use population. The new dermal absorption methodology considering surface loading had some impact, but did not change the order of key pathways. Published by Elsevier Ltd.
C1 [Xue, Jianping; Zartarian, Valerie; Tornero-Velez, Rogelio; Tulve, Nicolle S.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
RP Xue, JP (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM xue.jianping@epa.gov
FU United States Environmental Protection Agency, through its Office of
Research and Development
FX The United States Environmental Protection Agency, through its Office of
Research and Development, funded and managed the research described
here. It has been subjected to agency administrative review and approved
for publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 30
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U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 304
EP 311
DI 10.1016/j.envint.2014.08.008
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700035
PM 25192887
ER
PT J
AU Meyer, KM
Tufts, JA
Calfee, MW
Oudejans, L
AF Meyer, K. M.
Tufts, J. A.
Calfee, M. W.
Oudejans, L.
TI Efficacy of sporicidal wipes for inactivation of a Bacillus anthracis
surrogate
SO JOURNAL OF APPLIED MICROBIOLOGY
LA English
DT Article
DE anthrax; Bacillus anthracis; Bacillus atrophaeus; biological agent;
decontamination; sporicidal wipe
ID CLOSTRIDIUM-DIFFICILE SPORES; MICROBICIDAL ACTIVITIES; ENVIRONMENTAL
SURFACES; DISINFECTION METHODS; LABORATORY-SCALE; DECONTAMINATION;
CONTAMINATION
AB AimsTo evaluate five commercially available sporicidal wipes and two disinfecting wipes for their ability to inactivate Bacillus atrophaeus spores deposited onto various material surfaces.
Methods and ResultsDecontamination efficacy of the wipes was initially tested on glass Petri dishes (150mm diameter). Following exposure for a specified time of contact, survival of the spores was assessed by quantification of the remaining viable spores, both on the coupon surface and on the towelette itself, with efficacy quantified in terms of mean log reduction. Based on these data, five wipes were down-selected for evaluation on a larger scale, using 36x36cm coupons of five different material types.
ConclusionsResults suggest that sodium hypochlorite-based sporicidal wipes were most effective, having completely inactivated the Bacillus spores on the glass Petri dish and several materials. Additionally, results demonstrate that the manufacturer-prescribed contact times for Clostridium difficile achieved a 6 log(10) reduction of B.atrophaeus spores. Moreover, commercially available disinfecting wipes were not able to kill Bacillus spores as evaluated.
Significance and Impact of the StudyThese data show the potential of sporicidal wipes for decontamination of small, contained areas of biological contamination and may help on-scene coordinators develop remediation plans following a biological terrorism event.
C1 [Meyer, K. M.; Tufts, J. A.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Calfee, M. W.; Oudejans, L.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
RP Oudejans, L (reprint author), US EPA, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM oudejans.lukas@epa.gov
OI Calfee, Michael/0000-0001-6544-329X
FU U.S. Department of Energy; EPA
FX This research was supported in part by an appointment to the Research
Participation Program for the U.S. Environmental Protection Agency,
Office of Research and Development, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and EPA. The authors gratefully
acknowledge the critical reviews by Shannon Serre (EPA's Office of
Research and Development on detail with EPA's Office of Emergency
Management) and Frank Schaefer (EPA's Office of Research and
Development). This manuscript has been subject to an administrative
review; the views expressed here are those of the authors and do not
reflect the view or policies of the Agency. No official endorsement
should be inferred, as the EPA does not endorse the purchase or sale of
any commercial products or services.
NR 40
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U1 1
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1364-5072
EI 1365-2672
J9 J APPL MICROBIOL
JI J. Appl. Microbiol.
PD DEC
PY 2014
VL 117
IS 6
BP 1634
EP 1644
DI 10.1111/jam.12648
PG 11
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AU3JZ
UT WOS:000345510300010
PM 25220421
ER
PT J
AU Omernik, JM
Griffith, GE
AF Omernik, James M.
Griffith, Glenn E.
TI Ecoregions of the Conterminous United States: Evolution of a
Hierarchical Spatial Framework
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Ecoregions; Spatial frameworks; Ecosystem management; Regionalization;
United States; North America
ID LAND-COVER CHANGE; WATER-QUALITY MANAGEMENT; ECOLOGICAL REGIONS;
ECOSYSTEM MANAGEMENT; GREAT-PLAINS; USA; ECOREGIONALIZATION;
CLASSIFICATION; PERSPECTIVES; DELINEATION
AB A map of ecological regions of the conterminous United States, first published in 1987, has been greatly refined and expanded into a hierarchical spatial framework in response to user needs, particularly by state resource management agencies. In collaboration with scientists and resource managers from numerous agencies and institutions in the United States, Mexico, and Canada, the framework has been expanded to cover North America, and the original ecoregions (now termed Level III) have been refined, subdivided, and aggregated to identify coarser as well as more detailed spatial units. The most generalized units (Level I) define 10 ecoregions in the conterminous U.S., while the finest-scale units (Level IV) identify 967 ecoregions. In this paper, we explain the logic underpinning the approach, discuss the evolution of the regional mapping process, and provide examples of how the ecoregions were distinguished at each hierarchical level. The variety of applications of the ecoregion framework illustrates its utility in resource assessment and management.
C1 [Omernik, James M.; Griffith, Glenn E.] US EPA, US Geol Survey, Corvallis, OR 97333 USA.
RP Griffith, GE (reprint author), US EPA, US Geol Survey, 200 SW 35th St, Corvallis, OR 97333 USA.
EM omernik.james@epa.gov; ggriffith@usgs.gov
NR 112
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U1 6
U2 52
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD DEC
PY 2014
VL 54
IS 6
BP 1249
EP 1266
DI 10.1007/s00267-014-0364-1
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT7EN
UT WOS:000345099900002
PM 25223620
ER
PT J
AU Clark, BW
Bone, AJ
Di Giulio, RT
AF Clark, Bryan W.
Bone, A. J.
Di Giulio, R. T.
TI Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus
heteroclitus is strongly inherited despite reduced recalcitrance of the
AHR pathway
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Fundulus heteroclitus; Aryl hydrocarbon pathway; Polycyclic aromatic
hydrocarbons; Pollution adaptation; Cardiac teratogenesis
ID POLYCYCLIC AROMATIC-HYDROCARBONS; CREOSOTE-CONTAMINATED SITE;
DEVELOPMENTAL TOXICITY; ATLANTIC KILLIFISH; ELIZABETH RIVER; ALTERED
EXPRESSION; RECEPTOR AGONISTS; SUPERFUND SITE; IN-VITRO; FISH
AB Atlantic killifish (Fundulus heteroclitus) inhabiting the Atlantic Wood Superfund site on the Elizabeth River (Portsmouth, VA, USA) are exposed to a complex mixture of polycyclic aromatic hydrocarbons (PAHs) from former creosote operations, but are resistant to the acute toxicity and cardiac teratogenesis caused by PAHs. The resistance is associated with a dramatic recalcitrance to induction of cytochrome P450 (CYP1) metabolism enzymes following exposure to aryl hydrocarbon receptor (AHR) agonists, along with an elevated antioxidant response and increased expression of several other xenobiotic metabolism and excretion enzymes. However, the heritability of the resistance in the absence of chemical stressors has been inconsistently demonstrated. Understanding the heritability of this resistance will help clarify the nature of population-level responses to chronic exposure to PAH mixtures and aid in identifying the important mechanistic components of resistance to aryl hydrocarbons. We compared the response of Atlantic Wood F1 and F2 embryos to benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), 3,3',4,4',5-pentachlorobiphenyl (PCB-126), and a mixture of BkF and fluoranthene (Fl) to that of F1 embryos of reference site killifish. Resistance to cardiac teratogenesis and induction of CYP mRNA expression and CYP activity was determined. We found that both Atlantic Wood F1 and F2 embryos were highly resistance to cardiac teratogenesis. However, the resistance by Atlantic Wood F2 embryos to induction of CYP mRNA expression and enzyme activity was intermediate between that of Atlantic Wood F1 embryos and reference embryos. These results suggest that resistance to cardiac teratogenesis in Atlantic Wood fish is conferred by multiple factors, not all of which appear to be fully genetically heritable.
C1 [Clark, Bryan W.; Bone, A. J.; Di Giulio, R. T.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
RP Clark, BW (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM bwclark8@gmail.com
OI Bone, Audrey/0000-0002-8853-0553
FU National Institute of Environmental Health [P42ES10356]; Duke University
Integrated Toxicology Program [T32ES007031]
FX We thank Dr. Cole Matson, Dr. Lauren Wills, Dr. Dawoon Jung, Dr. Lindsey
Garner, and Daniel Brown for their assistance with fish collection and
exposure. This work was supported by the National Institute of
Environmental Health supported Superfund Research Program (P42ES10356)
and Duke University Integrated Toxicology Program (T32ES007031).
NR 46
TC 7
Z9 7
U1 2
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD DEC
PY 2014
VL 21
IS 24
BP 13898
EP 13908
DI 10.1007/s11356-013-2446-7
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU0LN
UT WOS:000345314500018
PM 24374617
ER
PT J
AU Yuan, LL
Pollard, AI
AF Yuan, Lester L.
Pollard, Amina I.
TI Classifying lakes to improve precision of nutrient-chlorophyll
relationships
SO FRESHWATER SCIENCE
LA English
DT Article
DE stressor-response; nutrients; chlorophyll; classification
ID CONTERMINOUS UNITED-STATES; MODEL SEARCH; FRESH-WATER; PHOSPHORUS;
EUTROPHICATION; CLASSIFICATION; ECOSYSTEMS; NITROGEN; TREES; TEMPERATURE
AB Accurate and precise estimates of relationships between stressors and environmental responses can inform management decisions most usefully when models can be easily interpreted. Here, we describe an approach for classifying lakes and reservoirs that can improve estimates of the relationships between total P (TP) and chlorophyll a (chl a) concentration, while preserving a model that can be readily interpreted by environmental managers and stakeholders. We selected classification variables statistically with a classification and regression tree in which relationships between TP and chl a were the terminal nodes of the tree. We developed a set of classification trees from bootstrapped replicates of the calibration data to explore a broader range of possible trees. We chose a final tree based on its predictive performance with a validation data set. The total N:TP mass ratio was the classification variable selected most frequently from a broad array of biological, chemical, and physical candidate classification variables. Relationships between TP and chl a in the resulting lake classes provided predictions that were substantially more accurate than predictions computed using nutrient ecoregions based on aggregations of Omernik Level III ecoregions, but predictions from a random forest model that averaged an ensemble of trees were even more accurate. Thus, the classification approach presented here sacrifices a small amount of predictive accuracy to retain a tree structure that is readily interpretable.
C1 [Yuan, Lester L.; Pollard, Amina I.] US EPA, Off Water, Washington, DC 20460 USA.
RP Yuan, LL (reprint author), US EPA, Off Water, 1200 Penn Ave,Mail Code 4304T, Washington, DC 20460 USA.
EM yuan.lester@epa.gov; pollard.amina@epa.gov
NR 54
TC 4
Z9 4
U1 4
U2 37
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 2161-9549
EI 2161-9565
J9 FRESHW SCI
JI Freshw. Sci.
PD DEC
PY 2014
VL 33
IS 4
BP 1184
EP 1194
DI 10.1086/678465
PG 11
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AT4PH
UT WOS:000344922000016
ER
PT J
AU Mackie, JA
Wostenberg, D
Doan, M
Craig, SF
Darling, JA
AF Mackie, Joshua A.
Wostenberg, Darren
Doan, Michael
Craig, Sean F.
Darling, John A.
TI High-throughput Illumina sequencing and microsatellite design in
Watersipora (Bryozoa), a complex of invasive species
SO CONSERVATION GENETICS RESOURCES
LA English
DT Article
DE De novo sequencing; Non-indigenous species; Marine fouling organism
AB The bryozoan genus Watersipora includes rapidly invading species that are becoming common globally. We used paired-end Illumina sequencing to identify thousands of potentially amplifiable microsatellite loci, enabling researchers to track patterns of the invasive spread, and to facilitate ecological and evolutionary question setting. We describe variability of nine loci within recently introduced populations of two Watersipora species in California.
C1 [Mackie, Joshua A.; Wostenberg, Darren] San Jose State Univ, San Jose, CA 95192 USA.
[Doan, Michael] ThermoFisher Sci, San Francisco, CA USA.
[Craig, Sean F.] Humboldt State Univ, Arcata, CA 95521 USA.
[Darling, John A.] US EPA, Durham, NC USA.
RP Mackie, JA (reprint author), San Jose State Univ, San Jose, CA 95192 USA.
EM joshuamackie@gmail.com
FU National Science Foundation [DBI-0959894]
FX Leslee Parr (SJSU), Frank Cipriano (San Francisco State University
Genomics/Transcriptomics Analysis Core), Robert Macey (Profile
Genomics), Dustin DeMeo (Profile Genomics, SJSU), Maria Bangal (SJSU),
Cerise Chen (California Academy of Sciences), Reggie Blackwell (HSU),
Jonathan Geller (Moss Landing Marine Laboratory), Steve Lonhart (South
West Fisheries Science Center, NOAA), Alexander Poole (University of
Colorado School of Medicine), Louise McKenzie (University of NSW), and
the Data Intensive Academic Grid (DIAG) support staff (University of
Maryland Institute for Genome Sciences) provided assistance or
resources. Computation was conducted on the National Science Foundation
funded MRI-R2 project #DBI-0959894. Though this study has been subjected
to US EPA administrative review and approved for publication, its
content does not necessarily reflect official Agency policy.
NR 5
TC 1
Z9 1
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1877-7252
EI 1877-7260
J9 CONSERV GENET RESOUR
JI Conserv. Genet. Resour.
PD DEC
PY 2014
VL 6
IS 4
BP 1053
EP 1055
DI 10.1007/s12686-014-0286-5
PG 3
WC Biodiversity Conservation; Genetics & Heredity
SC Biodiversity & Conservation; Genetics & Heredity
GA AS8EC
UT WOS:000344481900063
ER
PT J
AU Gabriel, M
Knightes, C
Dennis, R
Cooter, E
AF Gabriel, Mark
Knightes, Chris
Dennis, Robin
Cooter, Ellen
TI Potential Impact of Clean Air Act Regulations on Nitrogen Fate and
Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ
and SWAT
SO ENVIRONMENTAL MODELING & ASSESSMENT
LA English
DT Article
DE SWAT model; CMAQ model; Clean Air Act; Nitrogen; Watershed
ID NEW-YORK-STATE; NORTHEASTERN USA; UNITED-STATES; EASTERN USA;
FRESH-WATER; PHASE-I; DEPOSITION; ECOSYSTEMS; AMENDMENTS; EMISSIONS
AB There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impacts of CAAA NOx emissions on the fate and transport of nitrogen for two watersheds in the Neuse River Basin. We applied the Soil and Water Assessment Tool (SWAT) using simulated deposition rates from the Community Multiscale Air Quality (CMAQ) model. Two scenarios were investigated: one that considered CAAA emission controls in CMAQ simulation (with) and a second that did not (without). By 2020, results showed a 70 % drop in nitrogen discharge for the Little River watershed and a 50 % drop for the Nahunta watershed from 1990 levels under the with-CAAA scenario. Denitrification and plant nitrogen uptake played important roles in nitrogen discharge from each watershed. Nitrogen watershed response time to a change in atmospheric nitrogen deposition was 4 years for Nahunta and 2 years for Little River. We attribute these differences in nitrogen response time to contrasts in agricultural land use and diversity of crop types. Soybean, hay, and corn land covers had comparatively longer response times to changes in atmospheric deposition. The studied watersheds demonstrate relatively large nitrogen retention: >= 80 % of all delivered nitrogen.
C1 [Gabriel, Mark; Knightes, Chris] US EPA, Natl Exposure Res Lab NERL, Off Res & Dev ORD, Ecosystem Res Div ERD, Athens, GA 30605 USA.
[Dennis, Robin; Cooter, Ellen] US EPA, ORD, NERL, Atmospher Modeling & Anal Div AMAD, Res Triangle Pk, NC 27711 USA.
RP Gabriel, M (reprint author), US EPA, Natl Exposure Res Lab NERL, Off Res & Dev ORD, Ecosystem Res Div ERD, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM marklive02@yahoo.com
NR 39
TC 1
Z9 2
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1420-2026
EI 1573-2967
J9 ENVIRON MODEL ASSESS
JI Environ. Model. Assess.
PD DEC
PY 2014
VL 19
IS 6
BP 451
EP 465
DI 10.1007/s10666-014-9410-x
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT0CI
UT WOS:000344604200001
ER
PT J
AU Pearson, TRH
Brown, S
Sohngen, B
Henman, J
Ohrel, S
AF Pearson, Timothy R. H.
Brown, Sandra
Sohngen, Brent
Henman, Jennifer
Ohrel, Sara
TI Transaction costs for carbon sequestration projects in the tropical
forest sector
SO MITIGATION AND ADAPTATION STRATEGIES FOR GLOBAL CHANGE
LA English
DT Article
DE Climate change; Carbon projects; Forest carbon; Mitigation; Transaction
costs
AB There is general consensus that carbon (C) sequestration projects in forests are a relatively low cost option for mitigating climate change, but most studies on the subject have assumed that transaction costs are negligible. The objectives of the study were to examine transaction costs for forest C sequestration projects and to determine the significance of the costs based on economic analyses. Here we examine four case studies of active C sequestration projects being implemented in tropical countries and developed for the C market. The results from the case studies were then used with a dynamic forest and land use economic model to investigate how transaction costs affect the efficiency and cost of forest C projects globally. In the case studies transaction costs ranged from 0.38 to 27 million US dollars ($0.09 to $7.71/t CO2) or 0.3 to 270 % of anticipated income depending principally on the price of C and project size. The three largest cost categories were insurance (under the voluntary market; 41-89 % of total costs), monitoring (3-42 %) and regulatory approval (8-50 %). The global analysis indicated that most existing estimates of marginal costs of C sequestration are underestimated by up to 30 % because transaction costs were not included.
C1 [Pearson, Timothy R. H.; Brown, Sandra] Winrock Int Livestock Res & Training Ctr, Arlington, VA 22202 USA.
[Sohngen, Brent] Ohio State Univ, Columbus, OH USA.
[Henman, Jennifer] Climate Adapt Ltd, London, England.
[Ohrel, Sara] US EPA, Washington, DC 20460 USA.
RP Pearson, TRH (reprint author), Winrock Int Livestock Res & Training Ctr, 2121 Crystal Dr,Suite 500, Arlington, VA 22202 USA.
EM tpearson@winrock.org
FU U.S. Environmental Protection Agency
FX This paper was prepared with funding from the U.S. Environmental
Protection Agency. The opinions expressed in the report, however, are
the authors' and do not reflect, necessarily, the views of the EPA. We
express our great thanks to U.S. EPA Work Assignment Managers and to
Heidi Ries of Stratus Consulting, Inc. We also acknowledge the
assistance and generous provision of data from the anonymous case study
projects.
NR 15
TC 3
Z9 5
U1 1
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-2386
EI 1573-1596
J9 MITIG ADAPT STRAT GL
JI Mitig. Adapt. Strateg. Glob. Chang.
PD DEC
PY 2014
VL 19
IS 8
BP 1209
EP 1222
DI 10.1007/s11027-013-9469-8
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT2YQ
UT WOS:000344801000006
ER
PT J
AU Soller, JA
Schoen, ME
Varghese, A
Ichida, AM
Boehm, AB
Eftim, S
Ashbolt, NJ
Ravenscroft, JE
AF Soller, Jeffrey A.
Schoen, Mary E.
Varghese, Arun
Ichida, Audrey M.
Boehm, Alexandria B.
Eftim, Sorina
Ashbolt, Nicholas J.
Ravenscroft, John E.
TI Human health risk implications of multiple sources of faecal indicator
bacteria in a recreational waterbody
SO WATER RESEARCH
LA English
DT Article
DE Recreational water; Quantitative microbial risk assessment; Microbial
source apportionment; Faecal contamination
ID 16S RIBOSOMAL-RNA; RAPIDLY MEASURED INDICATORS; DOSE-RESPONSE;
GASTROINTESTINAL ILLNESS; CAMPYLOBACTER-JEJUNI; UNITED-STATES; MARINE
WATER; QUALITY; EXPOSURE; MARKERS
AB We simulate the influence of multiple sources of enterococci (ENT) as faecal indicator bacteria (FIB) in recreational water bodies on potential human health risk by considering waters impacted by human and animal sources, human and non-pathogenic sources, and animal and non-pathogenic sources. We illustrate that risks vary with the proportion of culturable ENT in water bodies derived from these sources and estimate corresponding ENT densities that yield the same level of health protection that the recreational water quality criteria in the United States seeks (benchmark risk). The benchmark risk is based on epidemiological studies conducted in water bodies predominantly impacted by human faecal sources. The key result is that the risks from mixed sources are driven predominantly by the proportion of the contamination source with the greatest ability to cause human infection (potency), not necessarily the greatest source(s) of FIB. Predicted risks from exposures to mixtures comprised of approximately 30% ENT from human sources were up to 50% lower than the risks expected from purely human sources when contamination is recent and ENT levels are at the current water quality criteria levels (35 CPU 100 mL(-1)). For human/non-pathogenic, human/gull, human/pig, and human/chicken faecal mixtures with relatively low human contribution, the predicted culturable enterococci densities that correspond to the benchmark risk are substantially greater than the current water quality criteria values. These findings are important because they highlight the potential applicability of site specific water quality criteria for waters that are predominantly un-impacted by human sources. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Soller, Jeffrey A.; Schoen, Mary E.] Soller Environm LLC, Berkeley, CA 94703 USA.
[Varghese, Arun; Ichida, Audrey M.; Eftim, Sorina] ICF Int LLC, Fairfax, VA 22031 USA.
[Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[Ashbolt, Nicholas J.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Ravenscroft, John E.] US EPA, Off Water, Off Sci & Technol, Washington, DC 20460 USA.
RP Soller, JA (reprint author), Soller Environm LLC, 3022 King St, Berkeley, CA 94703 USA.
EM jsoller@sollerenvironmental.com
OI Ravenscroft, John/0000-0002-8834-7310
FU U.S. EPA Office of Water, Office of Science and Technology
FX The research described in this article was funded by the U.S. EPA Office
of Water, Office of Science and Technology. This work has been subject
to formal Agency review, but does not necessarily reflect the views of
the Agency, and no official endorsement should be inferred. We are
grateful to Tim Bartrand for conducting the literature review for animal
sources, Martha Embrey, Elizabeth Doyle, and Betsy Behl for providing
invaluable review and technical edit of our draft manuscript, and Orin
Shanks for insightful comments.
NR 70
TC 18
Z9 18
U1 7
U2 43
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD DEC 1
PY 2014
VL 66
BP 254
EP 264
DI 10.1016/j.watres.2014.08.026
PG 11
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AT3GI
UT WOS:000344823500024
PM 25222329
ER
PT J
AU Procter, AC
Ellis, JC
Fay, PA
Polley, HW
Jackson, RB
AF Procter, Andrew C.
Ellis, J. Christopher
Fay, Philip A.
Polley, H. Wayne
Jackson, Robert B.
TI Fungal Community Responses to Past and Future Atmospheric CO2 Differ by
Soil Type
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ARBUSCULAR MYCORRHIZAL FUNGI; CARBON-DIOXIDE; FOREST SOILS; ELEVATED
CO2; GRASSLAND PRODUCTIVITY; TALLGRASS PRAIRIE; DIVERSITY; PLANT;
NITROGEN; ECOSYSTEM
AB Soils sequester and release substantial atmospheric carbon, but the contribution of fungal communities to soil carbon balance under rising CO2 is not well understood. Soil properties likely mediate these fungal responses but are rarely explored in CO2 experiments. We studied soil fungal communities in a grassland ecosystem exposed to a preindustrial-to-future CO2 gradient ( 250 to 500 ppm) in a black clay soil and a sandy loam soil. Sanger sequencing and pyrosequencing of the rRNA gene cluster revealed that fungal community composition and its response to CO2 differed significantly between soils. Fungal species richness and relative abundance of Chytridiomycota ( chytrids) increased linearly with CO2 in the black clay ( P < 0.04, R-2 > 0.7), whereas the relative abundance of Glomeromycota ( arbuscular mycorrhizal fungi) increased linearly with elevated CO2 in the sandy loam ( P = 0.02, R-2 = 0.63). Across both soils, decomposition rate was positively correlated with chytrid relative abundance ( r = 0.57) and, in the black clay soil, fungal species richness. Decomposition rate was more strongly correlated with microbial biomass ( r = 0.88) than with fungal variables. Increased labile carbon availability with elevated CO2 may explain the greater fungal species richness and Chytridiomycota abundance in the black clay soil, whereas increased phosphorus limitation may explain the increase in Glomeromycota at elevated O-2 in the sandy loam. Our results demonstrate that soil type plays a key role in soil fungal responses to rising atmospheric CO2.
C1 [Procter, Andrew C.; Ellis, J. Christopher; Jackson, Robert B.] Duke Univ, Dept Biol, Durham, NC USA.
[Fay, Philip A.; Polley, H. Wayne] ARS, Grassland Soil & Water Res Lab, USDA, Temple, TX USA.
[Jackson, Robert B.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
[Jackson, Robert B.] Stanford Univ, Sch Earth Sci, Stanford, CA 94305 USA.
RP Procter, AC (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM acprocter@gmail.com
OI Fay, Philip/0000-0002-8291-6316
FU U. S. Department of Energy (Program in Ecosystem Research) [ER64242]; U.
S. Department of Agriculture; Sigma Xi; National Science Foundation
FX This project was supported by funding from the U. S. Department of
Energy (Program in Ecosystem Research no. ER64242), the U. S. Department
of Agriculture, Sigma Xi, and the National Science Foundation.
NR 71
TC 8
Z9 8
U1 3
U2 50
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD DEC
PY 2014
VL 80
IS 23
BP 7364
EP 7377
DI 10.1128/AEM.02083-14
PG 14
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AS3FW
UT WOS:000344163700027
PM 25239904
ER
PT J
AU Johansson, E
Reponen, T
Meller, J
Vesper, S
Yadav, J
AF Johansson, Elisabet
Reponen, Tiina
Meller, Jarek
Vesper, Stephen
Yadav, Jagjit
TI Association of Streptomyces community composition determined by
PCR-denaturing gradient gel electrophoresis with indoor mold status
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Streptomyces; Denaturing gradient gel electrophoresis; House dust; Mold;
Decision trees
ID DAMAGED BUILDING-MATERIALS; RELATIVE MOLDINESS INDEX;
STACHYBOTRYS-CHARTARUM; QUANTITATIVE PCR; HOUSE-DUST; CALIFORNICUS;
HOMES; EXPOSURE; ASTHMA; AIR
AB Both Streptomyces species and mold species have previously been isolated from moisture-damaged building materials; however, an association between these two groups of microorganisms in indoor environments is not clear. In this study, we used a culture-independent method, PCR-denaturing gradient gel electrophoresis (PCR-DGGE), to investigate the composition of the Streptomyces community in house dust. Twenty-three dust samples each from two sets of homes categorized as high-mold and low-mold based on mold-specific quantitative PCR analysis were used in the study. Taxonomic identification of prominent bands was performed by cloning and sequencing. Associations between DGGE amplicon band intensities and home mold status were assessed using univariate analyses as well as multivariate recursive partitioning (decision trees) to test the predictive value of combinations of bands intensities. In the final classification tree, a combination of two bands was significantly associated with mold status of the home (p = 0.001). The sequence corresponding to one of the bands in the final decision tree matched a group of Streptomyces species that included Streptomyces coelicolor and Streptomyces sampsonii, both of which have been isolated from moisture-damaged buildings previously. The closest match for the majority of sequences corresponding to a second band consisted of a group of Streptomyces species that included Streptomyces hygroscopicus, an important producer of antibiotics and immunosuppressors. Taken together, the study showed that DGGE can be a useful tool for identifying bacterial species that may be more prevalent in mold-damaged buildings.
C1 [Johansson, Elisabet; Reponen, Tiina; Meller, Jarek; Yadav, Jagjit] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
[Vesper, Stephen] US EPA, Cincinnati, OH 45268 USA.
RP Johansson, E (reprint author), Cincinnati Childrens Hosp, Dept Pediat, 3333 Burnet Ave,ML 7037, Cincinnati, OH 45229 USA.
EM Hanna.Johansson@cchmc.org
FU National Institute for Occupational Safety and Health Pilot Research
Project Training Program of the University of Cincinnati Education and
Research Center [T42/OH008432-05]; National Institute of Environmental
Health Sciences [ES10957, ES11170]; US Department of Housing and Urban
Development [OHLHH0162-07]
FX This study was partially supported by National Institute for
Occupational Safety and Health Pilot Research Project Training Program
of the University of Cincinnati Education and Research Center Grant
#T42/OH008432-05. Additional funding came from the National Institute of
Environmental Health Sciences grants ES10957 and ES11170. The home
assessment was supported by the US Department of Housing and Urban
Development grant #OHLHH0162-07. The authors would like to thank Dr
Renuka Na and Dr Suman Pradhan for advice and assistance with the DGGE
method.
NR 35
TC 1
Z9 1
U1 0
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD DEC
PY 2014
VL 186
IS 12
BP 8773
EP 8783
DI 10.1007/s10661-014-4071-4
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AS6BF
UT WOS:000344349200052
PM 25331035
ER
PT J
AU Seifert-Monson, LR
Hill, BH
Kolka, RK
Jicha, TM
Lehto, LL
Elonen, CM
AF Seifert-Monson, L. R.
Hill, B. H.
Kolka, R. K.
Jicha, T. M.
Lehto, L. L.
Elonen, C. M.
TI Effects of sulfate deposition on pore water dissolved organic carbon,
nutrients, and microbial enzyme activities in a northern peatland
SO SOIL BIOLOGY & BIOCHEMISTRY
LA English
DT Article
DE Atmospheric deposition; Dissolved organic carbon; Peatland; Phosphorus;
Microbial enzyme activity
ID RIVERINE BACTERIOPLANKTON; SURFACE WATERS; CLIMATE-CHANGE; SOILS;
EXPORT; EUTROPHICATION; STOICHIOMETRY; DECOMPOSITION; SUBSTANCES;
ECOSYSTEMS
AB Export of dissolved organic carbon from lakes and streams has increased throughout Europe and North America over the past several decades. One possible cause is altered deposition chemistry; specifically, decreasing sulfate inputs leading to changes in ionic strength and dissolved organic carbon solubility. To further investigate the relationship between deposition chemistry and dissolved organic carbon export in peatlands, a field experiment was conducted to compare the pore water chemistry and peat microbial enzyme activity of mesocosms receiving sulfate amendments to mesocosms receiving no additions. To consider how peatlands respond during recovery from increased inputs of sulfate, samples were also analyzed from an area of the same peatland that was previously amended with sulfate. Current additions of sulfate decreased dissolved organic carbon concentration and increased dissolved organic carbon aromaticity. Total dissolved phosphorus decreased in response to current sulfate amendments but was elevated in the area of the peatland recovering from sulfate amendment. The total dissolved phosphorus increase, which was reflected in microbial enzyme activity, may have shifted the system from P limitation to N limitation. This shift could have important consequences for ecosystem processes related to plant and microbial communities. It also suggests that the recovery from previous sulfate amendments may take longer than may be expected. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Seifert-Monson, L. R.] Univ Minnesota, Integrated Biosci Grad Program, Duluth, MN 55812 USA.
[Hill, B. H.; Jicha, T. M.; Lehto, L. L.; Elonen, C. M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55894 USA.
[Kolka, R. K.] US Forest Serv, No Res Stn, Ctr Res Ecosyst Change, Grand Rapids, MN 55744 USA.
RP Seifert-Monson, LR (reprint author), 1411 North Rd, Duluth, MN 55811 USA.
EM seif0073@d.umn.edu
FU University of Minnesota-U.S. Environmental Protection Agency Cooperative
training partnership [CR83492801]
FX The authors would like to thank researchers at the Northern Research
Station of the USDA Forest service, including Deacon Kyllander, Carrie
Dorrance and Dr. Stephen Sebestyen, who provided general assistance,
watershed data, and information on trends of dissolved organic matter
export. Thanks to Dr. John Pastor and Dr. Josef Werne for advice on
study design and previous versions of this manuscript. This research was
funded through the University of Minnesota-U.S. Environmental Protection
Agency Cooperative training partnership (CR83492801).
NR 39
TC 3
Z9 3
U1 4
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0038-0717
J9 SOIL BIOL BIOCHEM
JI Soil Biol. Biochem.
PD DEC
PY 2014
VL 79
BP 91
EP 99
DI 10.1016/j.soilbio.2014.09.007
PG 9
WC Soil Science
SC Agriculture
GA AS7HX
UT WOS:000344428600012
ER
PT J
AU Garcia-Alonso, M
Hendley, P
Bigler, F
Mayeregger, E
Parker, R
Rubinstein, C
Satorre, E
Solari, F
McLean, M
AF Garcia-Alonso, Monica
Hendley, Paul
Bigler, Franz
Mayeregger, Edgar
Parker, Ronald
Rubinstein, Clara
Satorre, Emilio
Solari, Fernando
McLean, Morven A.
TI Transportability of confined field trial data for environmental risk
assessment of genetically engineered plants: a conceptual framework
SO TRANSGENIC RESEARCH
LA English
DT Article
DE Genetically engineered plant; Confined field trial; Regulatory
framework; Transportability; Agro-climatic zone
ID TRANSGENIC CROPS; YIELD; MANAGEMENT; WORLD
AB It is commonly held that confined field trials (CFTs) used to evaluate the potential adverse environmental impacts of a genetically engineered (GE) plant should be conducted in each country where cultivation is intended, even when relevant and potentially sufficient data are already available from studies conducted elsewhere. The acceptance of data generated in CFTs "out of country" can only be realized in practice if the agro-climatic zone where a CFT is conducted is demonstrably representative of the agro-climatic zones in those geographies to which the data will be transported. In an attempt to elaborate this idea, a multi-disciplinary Working Group of scientists collaborated to develop a conceptual framework and associated process that can be used by the regulated and regulatory communities to support transportability of CFT data for environmental risk assessment (ERA). As proposed here, application of the conceptual framework provides a scientifically defensible process for evaluating if existing CFT data from remote sites are relevant and/or sufficient for local ERAs. Additionally, it promotes a strategic approach to identifying CFT site locations so that field data will be transportable from one regulatory jurisdiction to another. Application of the framework and process should be particularly beneficial to public sector product developers and small enterprises that develop innovative GE events but cannot afford to replicate redundant CFTs, and to regulatory authorities seeking to improve the deployment of limited institutional resources.
C1 [Garcia-Alonso, Monica] Estel Consult Ltd, Binfield RG42 4HG, Berks, England.
[Hendley, Paul] Phasera Ltd, Bracknell RG12 2JJ, Berks, England.
[Bigler, Franz] Agroscope Reckenholz Tanikon, CH-8046 Zurich, Switzerland.
[Mayeregger, Edgar] Minist Agr, Unidad Gest Riesgo, Asuncion, Paraguay.
[Parker, Ronald] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Arlington, VA 22202 USA.
[Rubinstein, Clara] ILSI Argentina, Buenos Aires, DF, Argentina.
[Satorre, Emilio] Univ Buenos Aires, Fac Agron & Vet, Catedra Cerealicultura, IFEVA, Buenos Aires, DF, Argentina.
[Solari, Fernando] Monsanto Argentina SAIC, Estn Expt Fontezuela, Buenos Aires, DF, Argentina.
[McLean, Morven A.] ILSI Res Fdn, Ctr Environm Risk Assessment, Washington, DC 20005 USA.
RP McLean, M (reprint author), ILSI Res Fdn, Ctr Environm Risk Assessment, 1156 Fifteenth St NW,Suite 200, Washington, DC 20005 USA.
EM mmclean@ilsi.org
FU United States Department of Agriculture Emerging Markets Program
FX Funding in support of this project was provided by the United States
Department of Agriculture Emerging Markets Program Grant 2010-2040.
NR 64
TC 6
Z9 6
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-8819
EI 1573-9368
J9 TRANSGENIC RES
JI Transgenic Res.
PD DEC
PY 2014
VL 23
IS 6
BP 1025
EP 1041
DI 10.1007/s11248-014-9785-0
PG 17
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA AS3EH
UT WOS:000344158800011
PM 24733670
ER
PT J
AU Conmy, RN
AF Conmy, Robyn N.
TI Robyn N. Conmy
SO OCEANOGRAPHY
LA English
DT Biographical-Item
C1 [Conmy, Robyn N.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Conmy, RN (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM conmy.robyn@epa.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OCEANOGRAPHY SOC
PI ROCKVILLE
PA P.O. BOX 1931, ROCKVILLE, MD USA
SN 1042-8275
J9 OCEANOGRAPHY
JI Oceanography
PD DEC
PY 2014
VL 27
IS 4
SU S
BP 87
EP 87
PG 1
WC Oceanography
SC Oceanography
GA V44BO
UT WOS:000209724700048
ER
PT J
AU Bradman, A
Castorina, R
Gaspar, F
Nishioka, M
Colon, M
Weathers, W
Egeghy, PP
Maddalena, R
Williams, J
Jenkins, PL
McKone, TE
AF Bradman, Asa
Castorina, Rosemary
Gaspar, Fraser
Nishioka, Marcia
Colon, Maribel
Weathers, Walter
Egeghy, Peter P.
Maddalena, Randy
Williams, Jeffery
Jenkins, Peggy L.
McKone, Thomas E.
TI Flame retardant exposures in California early childhood education
environments
SO CHEMOSPHERE
LA English
DT Article
DE Child care; Children; Exposure; Flame retardant; PBDEs
ID POLYBROMINATED DIPHENYL ETHERS; IN-HOUSE DUST; SERUM CONCENTRATIONS;
HORMONE DISRUPTION; THYROID-HORMONE; PHASE-OUT; PBDES; ASSOCIATIONS;
PRODUCTS; SAMPLES
AB Infants and young children spend as much as 50 h per week in child care and preschool. Although approximately 13 million children, or 65% of all U.S. children, spend some time each day in early childhood education (ECE) facilities, little information is available about environmental exposures in these environments. We measured flame retardants in air and dust collected from 40 California ECE facilities between May 2010 and May 2011. Low levels of six polybrominated diphenyl ether (PBDE) congeners and four non-PBDE flame retardants were present in air, including two constituents of Firemaster 550 and two tris phosphate compounds [tris (2-chloroethyl) phosphate (TCEP) and tris (1,3-dichloroisopropyl) phosphate (TDCIPP)]. Tris phosphate, Firemaster 550 and PBDE compounds were detected in 100% of the dust samples. BDE47, BDE99, and BDE209 comprised the majority of the PBDE mass measured in dust. The median concentrations of TCEP (319 ng g(-1)) and TDCIPP (2265 ng g(-1)) were similar to or higher than any PBDE congener. Levels of TCEP and TDCIPP in dust were significantly higher in facilities with napping equipment made out of foam (Mann Whitney p-values < 0.05). Child BDE99 dose estimates exceeded the RID in one facility for children < 3 years old. In 51% of facilities, TDCIPP dose estimates for children < 6 years old exceeded age-specific "No Significant Risk Levels (NSRLs)" based on California Proposition 65 guidelines for carcinogens. Given the overriding interest in providing safe and healthy environments for young children, additional research is needed to identify strategies to reduce indoor sources of flame retardant chemicals. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bradman, Asa; Castorina, Rosemary; Gaspar, Fraser; McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Ctr Environm Res & Childrens Hlth, Berkeley, CA 94704 USA.
[Nishioka, Marcia] Battelle Mem Inst, Columbus, OH 43201 USA.
[Colon, Maribel; Weathers, Walter; Egeghy, Peter P.] US EPA, Res Triangle Pk, NC 27711 USA.
[Maddalena, Randy; McKone, Thomas E.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Williams, Jeffery; Jenkins, Peggy L.] Calif Air Resources Board, Sacramento, CA USA.
RP Bradman, A (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Ctr Environm Res & Childrens Hlth, 1995 Univ Ave,Suite 265, Berkeley, CA 94704 USA.
EM abradman@berkeley.edu
OI Gaspar, Fraser/0000-0002-0782-5721
FU California Air Resources Board (ARB) [08-305]
FX This research was funded by the California Air Resources Board (ARB
Contract No. 08-305). This work does not necessarily reflect the opinion
or official policy of the ARB. Although this work was reviewed by U.S.
EPA and approved for publication, it does not necessarily reflect the
opinion or official policy of the U.S. EPA. Co-author Walter Weathers
has recently retired from the U.S. EPA.
NR 44
TC 18
Z9 18
U1 4
U2 61
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD DEC
PY 2014
VL 116
SI SI
BP 61
EP 66
DI 10.1016/j.chemosphere.2014.02.072
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5KH
UT WOS:000343623200010
PM 24835158
ER
PT J
AU Davis, EL
AF Davis, Eva L.
TI Discussion of Paper
SO GROUND WATER MONITORING AND REMEDIATION
LA English
DT Editorial Material
C1 US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74821 USA.
RP Davis, EL (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, POB 1198, Ada, OK 74821 USA.
EM Davis.Eva@epa.gov
NR 7
TC 0
Z9 0
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-3629
EI 1745-6592
J9 GROUND WATER MONIT R
JI Ground Water Monit. Remediat.
PD WIN
PY 2014
VL 34
IS 1
BP 27
EP 28
DI 10.1111/gwmr.12043
PG 2
WC Water Resources
SC Water Resources
GA AB2IU
UT WOS:000331617200017
ER
PT J
AU Loperfido, JV
Noe, GB
Jarnagin, ST
Hogan, DM
AF Loperfido, J. V.
Noe, Gregory B.
Jarnagin, S. Taylor
Hogan, Dianna M.
TI Effects of distributed and centralized stormwater best management
practices and land cover on urban stream hydrology at the catchment
scale
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Stormwater best management practices; Low impact development;
Distributed treatment systems; Urban hydrology; Land cover; Chesapeake
Bay
ID LOW IMPACT DEVELOPMENT; WATER MANAGEMENT; INFILTRATION; BASEFLOW;
RUNOFF; PERFORMANCE
AB Urban stormwater runoff remains an important issue that causes local and regional-scale water quantity and quality issues. Stormwater best management practices (BMPs) have been widely used to mitigate runoff issues, traditionally in a centralized manner; however, problems associated with urban hydrology have remained. An emerging trend is implementation of BMPs in a distributed manner (multi-BMP treatment trains located on the landscape and integrated with urban design), but little catchment-scale performance of these systems have been reported to date. Here, stream hydrologic data (March, 2011September, 2012) are evaluated in four catchments located in the Chesapeake Bay watershed: one utilizing distributed stormwater BMPs, two utilizing centralized stormwater BMPs, and a forested catchment serving as a reference. Among urban catchments with similar land cover, geology and BMP design standards (i.e. 100-year event), but contrasting placement of stormwater BMPs, distributed BMPs resulted in: significantly greater estimated baseflow, a higher minimum precipitation threshold for stream response and maximum discharge increases, better maximum discharge control for small precipitation events, and reduced runoff volume during an extreme (1000-year) precipitation event compared to centralized BMPs. For all catchments, greater forest land cover and less impervious cover appeared to be more important drivers than stormwater BMP spatial pattern, and caused lower total, stormflow, and baseflow runoff volume; lower maximum discharge during typical precipitation events; and lower runoff volume during an extreme precipitation event. Analysis of hydrologic field data in this study suggests that both the spatial distribution of stormwater BMPs and land cover are important for management of urban stormwater runoff. In particular, catchment-wide application of distributed BMPs improved stream hydrology compared to centralized BMPs, but not enough to fully replicate forested catchment stream hydrology. Integrated planning of stormwater management, protected riparian buffers and forest land cover with suburban development in the distributed-BMP catchment enabled multi-purpose use of land that provided esthetic value and green-space, community gathering points, and wildlife habitat in addition to hydrologic stormwater treatment. Published by Elsevier B.V.
C1 [Loperfido, J. V.; Hogan, Dianna M.] US Geol Survey, Eastern Geog Sci Ctr, Reston, VA 20192 USA.
[Noe, Gregory B.] US Geol Survey, Natl Res Program, Reston, VA 20192 USA.
[Jarnagin, S. Taylor] US Environm Protect Agcy, ORD NERL ESD, Landscape Ecol Branch, Res Triangle Pk, NC 27711 USA.
RP Loperfido, JV (reprint author), US Geol Survey, Eastern Geog Sci Ctr, 521 Natl Ctr, Reston, VA 20192 USA.
EM jloperfido@usgs.gov; gnoe@usgs.gov; jarnagin.taylor@epa.gov;
dhogan@usgs.gov
OI Noe, Gregory/0000-0002-6661-2646
FU U.S. Geological Survey (USGS); United States Environmental Protection
Agency [DW14921533, DW14921811, DW14922385]; Montgomery County
Department of Environmental Protection; Fairfax County, VA
FX This work was supported by the following U.S. Geological Survey (USGS)
Programs: Mendenhall Research Fellowship Program, Land Change Science,
Chesapeake Priority Ecosystem Studies, and the National Research
Program. The authors appreciate contributions from Keith Van Ness
(Montgomery County Department of Environmental Protection); Annette
Hall, Daniel K. Jones, and Brianna Hammond (USGS Eastern Geographic
Science Center); John Jastram and Ken Hyer (USGS Virginia Water Science
Center); Ed Doheny and Matt Baker (USGS Maryland-DelawareD.C. Water
Science Center); Barry Croke for hydrologic discussions; and reviews
from Bill Selbig, T.A. Endreny, and anonymous reviewers. The United
States Environmental Protection Agency through its Office of Research
and Development collaborated in the research described here. The
manuscript has been subjected to Agency review and approved for
publication. The streamflow data referenced in this document have been
funded in part by the United States Environmental Protection Agency
under assistance agreements DW14921533, DW14921811, and DW14922385 to
the U.S. Geological Survey, Montgomery County Department of
Environmental Protection, and Fairfax County, VA.
NR 45
TC 24
Z9 25
U1 20
U2 92
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
SI SI
BP 2584
EP 2595
DI 10.1016/j.jhydrol.2014.07.007
PN C
PG 12
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5ED
UT WOS:000347595000019
ER
PT J
AU Jiang, Y
Frankenberger, JR
Bowling, LC
Sun, ZN
AF Jiang, Yan
Frankenberger, Jane R.
Bowling, Laura C.
Sun, Zhaonan
TI Quantification of uncertainty in estimated nitrate-N loads in
agricultural watersheds
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Nitrate-N load; Measurement uncertainty; Load calculation uncertainty;
Error propagation
ID ARTIFICIALLY DRAINED CATCHMENTS; LAURENTIAN GREAT-LAKES; RIVER
DISCHARGE; NUTRIENT INPUTS; RATING CURVE; QUALITY DATA; PHOSPHORUS;
NITROGEN; ALGORITHMS; STRATEGIES
AB Estimation of annual nutrient loads is critical for many applications in water quality management; however, measurement errors and infrequent monitoring could raise considerable uncertainty in the load estimations. The objectives of this study were to quantify the overall uncertainty in annual nitrate-N load estimates. Nitrate was selected as the study object because of the high loads common in Midwestern streams, and its important influence on hypoxia in the Gulf of Mexico. A standard error propagation method was used to quantify the uncertainty from both measurement and load calculation processes to evaluate the accumulative effect. The measurement uncertainty was assessed based on standard information; the load calculation uncertainty was evaluated through numerical simulation. The study found that uncertainty in annual nitrate-N load estimates for a 30-day sampling frequency, expressed as coefficient of variation (CV), was 14-34%. This included measurement (flow and concentration) uncertainty of 12% and load calculation uncertainty of 7-32%. These results can be used to evaluate different uncertainty sources, estimate uncertainty for similar watersheds, and design sampling programs balancing cost and accuracy. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jiang, Yan] US EPA, Las Vegas, NV 89119 USA.
[Frankenberger, Jane R.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA.
[Bowling, Laura C.] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
[Sun, Zhaonan] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA.
RP Jiang, Y (reprint author), US EPA, 944 Harmon Ave, Las Vegas, NV 89119 USA.
EM enaj1125@gmail.com
RI Bowling, Laura/B-6963-2013
OI Bowling, Laura/0000-0002-1439-3154
NR 54
TC 5
Z9 5
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 106
EP 116
DI 10.1016/j.jhydrol.2014.06.027
PN A
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500009
ER
PT J
AU Hathaway, JM
Brown, RA
Fu, JS
Hunt, WF
AF Hathaway, J. M.
Brown, R. A.
Fu, J. S.
Hunt, W. F.
TI Bioretention function under climate change scenarios in North Carolina,
USA
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Bioretention; Biofilter; Hydrology; Climate change; Water balance;
DRAINMOD
ID PRECIPITATION EXTREMES; POLLUTANT REMOVAL; IMPACTS; PERFORMANCE;
DRAINAGE; STORMWATER; HYDROLOGY; WATER; MITIGATION; SYSTEMS
AB The effect of climate change on stormwater controls is largely unknown. Evaluating such effects is important for understanding how well resiliency can be built into urban watersheds by implementing these systems. Bioretention areas with varied media depths, in situ soil types, drainage configurations, and surface infiltration capabilities have previously been monitored, modelled, and calibrated using the continuous simulation model, DRAINMOD. In this study, data from downscaled climate projections for 2055 through 2058 were utilized in these models to evaluate changes in system hydrologic function under two climate change scenarios (RCP 4.5 and 8.5). The results were compared to those generated using a "Base" scenario of observed data from 2001 to 2004. The results showed a modest change in the overall water balance of the system. In particular, the frequency and magnitude of overflow from the systems substantially increased under the climate change scenarios. As this represents an increase in the amount of uncontrolled, untreated runoff from the contributing watersheds, it is of particular concern. Further modelling showed that between 9.0 and 31.0 cm of additional storage would be required under the climate change scenarios to restrict annual overflow to that of the base scenario. Bioretention surface storage volume and infiltration rate appeared important in determining a system's ability to cope with increased yearly rainfall and higher rainfall magnitudes. As climate change effects vary based on location, similar studies should be performed in other locations to determine localized effects on stormwater controls. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Hathaway, J. M.; Fu, J. S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Brown, R. A.] US EPA, Edison, NJ USA.
[Hunt, W. F.] N Carolina State Univ, Dept Biol & Agr Engn, Raleigh, NC 27695 USA.
RP Hathaway, JM (reprint author), Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
EM hathaway@utk.edu
NR 33
TC 5
Z9 5
U1 8
U2 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 503
EP 511
DI 10.1016/j.jhydrol.2014.07.037
PN A
PG 9
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500041
ER
PT J
AU Guber, AK
Pachepsky, YA
Yakirevich, AM
Shelton, DR
Whelan, G
Goodrich, DC
Unkrich, CL
AF Guber, A. K.
Pachepsky, Y. A.
Yakirevich, A. M.
Shelton, D. R.
Whelan, G.
Goodrich, D. C.
Unkrich, C. L.
TI Modeling runoff and microbial overland transport with KINEROS2/STWIR
model: Accuracy and uncertainty as affected by source of infiltration
parameters
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Bacteria; Runoff; Uncertainty; Modeling; Infiltration parameters
ID SOIL-WATER RETENTION; ARTIFICIAL NEURAL-NETWORK; VEGETATIVE FILTER
STRIPS; HYDRAULIC CONDUCTIVITY; PEDOTRANSFER FUNCTIONS; COLIFORM
BACTERIA; BROOKS-COREY; BULK-DENSITY; FLOW; SCALE
AB Infiltration is important to modeling the overland transport of microorganisms in environmental waters. In watershed- and hillslope scale-models, infiltration is commonly described by simple equations relating infiltration rate to soil saturated conductivity and by empirical parameters defining changes in infiltration rate with soil water content. For the microbial transport model KINEROS2/STWIR used in this study, infiltration in unsaturated soil is accounted for by a net capillary drive parameter, G, in the Parlange equation. Scarce experimental data and multiple approaches for estimating parameter G introduce uncertainty, reducing reliability of overland water flow and microbial transport models. Our objectives were to evaluate reliability and robustness of three methods to estimate parameter G and associated accuracy and uncertainty in predicting runoff and fecal coliform (FC) transport. These methods include (i) KINEROS2 fitting to the experimental cumulative runoff data; (ii) estimating solely on soil texture; and (iii) estimating by individual pedotransfer functions (PTFs) and an ensemble of PTFs from basic soil properties. Results show that the most accurate prediction was obtained when the G parameter was fitted to the cumulative runoff. The KINEROS2-recommended parameter slightly overestimated the calibrated value of parameter G and yielded less accurate predictions of runoff, FC concentrations and total FC. The PTFs-estimated parameters systematically deviated from calibrated G values that caused high uncertainty in the KINEROS2/STWIR predictions. Averaging PTF estimates considerably improved model accuracy, reducing the uncertainty of runoff and FC concentration predictions. Overall, ensemble-based PTF estimation of the capillary drive can be efficient for simulations of runoff and bacteria overland transport when a single effective value is used across the study area. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Guber, A. K.] Michigan State Univ, Dept Plant Soil & Microbial Sci, E Lansing, MI 48824 USA.
[Pachepsky, Y. A.; Shelton, D. R.] USDA ARS, Environm Microbial & Food Safety Lab, Beltsville, MD 20705 USA.
[Yakirevich, A. M.] Ben Gurion Univ Negev, Zuckerberg Inst Water Res, J Blaustein Inst Desert Res, IL-84990 Sede Boqer, Israel.
[Whelan, G.] US EPA, Athens, GA 30605 USA.
[Goodrich, D. C.; Unkrich, C. L.] USDA ARS, Southwest Watershed Res Ctr, Tucson, AZ 85719 USA.
RP Guber, AK (reprint author), Michigan State Univ, Dept Plant Soil & Microbial Sci, 1066 Bogue St,Room 584D, E Lansing, MI 48824 USA.
EM Akguber@msu.edu; yakov.pachepsky@ars.usda.gov; alexy@bgu.ac.il;
whelan.gene@epa.gov; dave.goodrich@ars.usda.gov
OI Pachepsky, Yakov/0000-0003-0232-6090
NR 72
TC 4
Z9 5
U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 644
EP 655
DI 10.1016/j.jhydrol.2014.08.005
PN A
PG 12
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500053
ER
PT J
AU Wang, DJ
Su, CM
Zhang, W
Hao, XZ
Cang, L
Wang, YJ
Zhou, DM
AF Wang, Dengjun
Su, Chunming
Zhang, Wei
Hao, Xiuzhen
Cang, Long
Wang, Yujun
Zhou, Dongmei
TI Laboratory assessment of the mobility of water-dispersed engineered
nanoparticles in a red soil (Ultisol)
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Engineered nanoparticle; Red soil; Ultisol; Transport; Modeling; Porous
media
ID HETEROGENEOUS POROUS-MEDIA; LABELED HYDROXYAPATITE NANOPARTICLES;
STABILIZED SILVER NANOPARTICLES; WALLED CARBON NANOTUBES; COLLOID
TRANSPORT; NATURAL SOILS; FULLERENE NANOPARTICLES; FACILITATED
TRANSPORT; PREFERENTIAL FLOW; SURFACE-CHARGE
AB Soils are major sinks of engineered nanoparticles (ENPs) as results of land applications of sewage sludge, accidental spills, or deliberate applications of ENPs (e.g., nano-pesticides). In this study, the transport behaviors of four widely used ENPs (i.e., titanium dioxide [TiO2], buckminsterfullerene [C-60], single-walled carbon nanotube [SWNT], and elemental silver [Ag-0]) were investigated in water-saturated columns packed with either a quartz sand, a red soil (Ultisol), or sand/soil mixtures with soil mass fraction (lambda) from 0% to 100% at slightly acidic solution pH (4.0-5.0). The mobility of tested ENPs decreased significantly with increasing lambda, which was attributed to increased surface area and/or retention sites imparted by iron oxides, clay minerals, and organic matter in the red soil. Breakthrough curves of all ENPs exhibited blocking effects (decreasing deposition rate over time) and were well-described using an unfavorable and favorable, two-site kinetic attachment model accounting for random sequential adsorption on the favorable site. Modeled maximum retention capacity and first-order attachment rate coefficient on the favorable site both increased linearly with increasing lambda, suggesting that transport parameters of ENPs in natural soils may be accurately extrapolated from transport parameters in the sand/soil mixtures. In addition, the mobility of three negatively charged ENPs (C-60, SWNT, and Ag-0 NPs) was reversely correlated with their average hydrodynamic diameters, highlighting that the average hydrodynamic diameter of negatively charged ENPs is the dominant physicochemical characteristics controlling their mobility in the Ultisol. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wang, Dengjun; Hao, Xiuzhen; Cang, Long; Wang, Yujun; Zhou, Dongmei] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Peoples R China.
[Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, Ada, OK 74820 USA.
[Zhang, Wei] Michigan State Univ, Dept Plant Soil & Microbial Sci, Environm Sci & Policy Program, E Lansing, MI 48824 USA.
[Wang, Dengjun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
RP Zhou, DM (reprint author), Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Peoples R China.
EM dmzhou@issas.ac.cn
RI Wang, Yujun/C-6962-2013; Cang, Long/D-1155-2015;
OI Wang, Yujun/0000-0002-0921-0122; Zhang, Wei/0000-0002-2937-1732
FU National Basic Research and Development Program of China [2013CB934303];
National Natural Science Foundation of China [41125007]; USDA National
Institute of Food and Agriculture Hatch Program [MICL02248]
FX This research was supported by National Basic Research and Development
Program of China (2013CB934303), National Natural Science Foundation of
China (41125007), and USDA National Institute of Food and Agriculture
Hatch Program (MICL02248). This paper does not necessarily reflect the
views of USEPA, USDA and other funding agencies, and no official
endorsement should be inferred. The authors thank Dr. Xinhua Peng at our
Institute for assistance with measurements of the BET specific surface
area and pore size of the red soil. Comments and suggestions from two
anonymous reviewers and Editors (Dr. Laurent Charlet and Dr. Eddy
Yongping Zeng) helped us improve an earlier version of this paper.
NR 78
TC 9
Z9 10
U1 9
U2 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 1677
EP 1687
DI 10.1016/j.jhydrol.2014.09.053
PN B
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AX6FH
UT WOS:000347018100036
ER
PT J
AU Ziegler, AD
Benner, SG
Tantasirin, C
Wood, SH
Sutherland, RA
Sidle, RC
Jachowski, N
Nullet, MA
Xi, LX
Snidvongs, A
Giambelluca, TW
Fox, JM
AF Ziegler, Alan D.
Benner, Shawn G.
Tantasirin, Chatchai
Wood, Spencer H.
Sutherland, Ross A.
Sidle, Roy C.
Jachowski, Nicholas
Nullet, Mike A.
Xi, Lu Xi
Snidvongs, Anond
Giambelluca, Thomas W.
Fox, Jefferson M.
TI Turbidity-based sediment monitoring in northern Thailand: Hysteresis,
variability, and uncertainty
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Soil erosion in the tropics; Stream sediment dynamics; Catchment
management; Southeast Asia; Landslides
ID MAINLAND SOUTHEAST-ASIA; TOTAL SUSPENDED-SOLIDS; HORTON OVERLAND-FLOW;
RIVER-BASIN; LAND-USE; UPLAND CATCHMENTS; WATER MANAGEMENT; MOUNTAIN
ROADS; RATING CURVES; SOURCE AREAS
AB Annual total suspended solid (TSS) loads in the Mae Sa Catchment in northern Thailand, determined with an automated, turbidity-based monitoring approach, were approximately 62,000, 33,000, and 14,000 Mg during the three years of observation. These loads were equivalent to basin yields of 839 (603-1170), 445 (217-462), and 192 (108-222) Mg km(-2) for the 74.16-km(2) catchment during 2006, 2007, and 2008, respectively. The yearly uncertainty ranges indicate our loads may be underestimated by 38-43% or overestimated by 28-33%. In determining the annual loads, discharge (Q) and turbidity (T) values were compared against 333 hand-sampled total suspended solid concentrations (TSS) measured during 18 runoff events and other flow conditions across the three-year period. Annual rainfall varied from 1632 to 1934 mm; and catchment runoff coefficients (annual runoff/annual rainfall) ranged from 0.25 to 0.41. Measured TSS ranged from 8 to 15,900 mg l(-1); the low value was associated with dry-season base flow; the latter, a wet-season storm. Storm size and location played an important role in producing clockwise, anticlockwise, and complex hysteresis in the Q-TSS relationship. Turbidity alone was a good estimator for turbidity ranges of roughly 10-2800 NTU (or concentrations approximately 25-4000 mg l(-1)). However, owing to hysteresis and high sediment concentrations that surpass the detection limits of the turbidity sensor during many annual storms, TSS was estimated best using a complex multiple regression equation based on high/low ranges of turbidity and Q as independent variables. Turbidity was not a good predictor of TSS fractions >2000 mu m. Hysteresis in the monthly Q-TSS relationship was generally clockwise over the course of the monsoon season, but infrequent large dry-season storms disrupted the pattern in some years. The large decrease in annual loads during the study was believed to be related to depletion of fine sediment delivered to the stream by several landslides occurring the year prior to the study. The study indicated the importance of monitoring Q and turbidity at fine resolutions (e.g., sub-hourly) to capture the TSS dynamics and to make accurate load estimations in this flashy headwater stream where hysteresis in the Q-TSS signature varied at several time scales. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ziegler, Alan D.; Jachowski, Nicholas; Xi, Lu Xi] Natl Univ Singapore, Dept Geog, Singapore 117568, Singapore.
[Benner, Shawn G.; Wood, Spencer H.] Boise State Univ, Dept Geosci, Boise, ID 83725 USA.
[Tantasirin, Chatchai] Kasetsart Univ, Dept Conservat, Bangkok, Thailand.
[Sutherland, Ross A.; Nullet, Mike A.; Giambelluca, Thomas W.] Univ Hawaii Manoa, Dept Geog, Honolulu, HI 96822 USA.
[Sidle, Roy C.] US EPA, Athens, GA USA.
[Snidvongs, Anond] START Thailand, Bangkok, Thailand.
[Snidvongs, Anond] Chulalongkorn Univ, Bangkok, Thailand.
[Giambelluca, Thomas W.] Nagoya Univ, Hydrospher Atmospher Res Ctr, Nagoya, Aichi 4648601, Japan.
[Fox, Jefferson M.] East West Ctr, Honolulu, HI USA.
RP Ziegler, AD (reprint author), Natl Univ Singapore, Dept Geog, 1 Arts Link Kent Ridge,AS02-04021, Singapore 117568, Singapore.
EM geoadz@nus.edu.sg
RI Benner, Shawn/A-2557-2012;
OI Benner, Shawn/0000-0003-4024-5777; Giambelluca,
Thomas/0000-0002-6798-3780
FU SARCS [95/01/CW-005]; APN [ARCP2006-06NMY, ARCP2007-01CMY]; NASA
[NNG04GH59G]; NUS [R-109-000-092-133, R-109-000-134-112]
FX This project was supported by SARCS grant 95/01/CW-005; APN grants
ARCP2006-06NMY, ARCP2007-01CMY & ARCP2007-01CMY; NASA grant NNG04GH59G,
and NUS grants R-109-000-092-133 and R-109-000-134-112. A special thanks
is given to Ms. Wimonmat Nuipakdee (Department of National Park,
Wildlife and Plants Conservation, Thailand) for providing access to the
research site. This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use.
NR 106
TC 8
Z9 8
U1 5
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 2020
EP 2039
DI 10.1016/j.jhydrol.2014.09.010
PN B
PG 20
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AX6FH
UT WOS:000347018100065
ER
PT J
AU Hand, JL
Schichtel, BA
Malm, WC
Pitchford, M
Frank, NH
AF Hand, J. L.
Schichtel, B. A.
Malm, W. C.
Pitchford, M.
Frank, N. H.
TI Spatial and seasonal patterns in urban influence on regional
concentrations of speciated aerosols across the United States
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID FINE PARTICULATE MATTER; LONG-TERM NETWORKS; NEW-YORK-CITY;
ORGANIC-CARBON; CHEMICAL-COMPOSITION; AIR-QUALITY; SAMPLING ARTIFACTS;
TRENDS NETWORK; PM2.5 EPISODES; PART 1
AB Monthly, seasonal, and annual mean estimates of urban influence on regional concentrations of major aerosol species were computed using speciated aerosol data from the rural IMPROVE network (Interagency Monitoring of Protected Visual Environments) and the United States Environmental Protection Agency's urban Chemical Speciation Network for the 2008 through 2011 period. Aggregated for sites across the continental United States, the annual mean and one standard error in urban excess (defined as the ratio of urban to nearby rural concentrations) was highest for elemental carbon (3.3 +/- 0.2), followed by ammonium nitrate (2.5 +/- 0.2), particulate organic matter (1.78 +/- 0.08), and ammonium sulfate (1.23 +/- 0.03). The seasonal variability in urban excess was significant for carbonaceous aerosols and ammonium nitrate in the West, in contrast to the low seasonal variability in the urban influence of ammonium sulfate. Generally for all species, higher excess values in the West were associated with localized urban sources while in the East excess was more regional in extent. In addition, higher excess values in the western United States in winter were likely influenced not only by differences in sources but also by combined meteorological and topographic effects. This work has implications for understanding the spatial heterogeneity of major aerosol species near the interface of urban and rural regions and therefore for designing appropriate air quality management strategies. In addition, the spatial patterns in speciated mass concentrations provide constraints for regional and global models.
C1 [Hand, J. L.; Malm, W. C.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
[Schichtel, B. A.] Natl Pk Serv, Air Resources Div, Lakewood, CO USA.
[Pitchford, M.] Univ Nevada, Desert Res Inst, Div Atmospher Sci, Reno, NV 89506 USA.
[Frank, N. H.] US EPA, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA.
RP Hand, JL (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
EM jlhand@colostate.edu
FU U.S. Environmental Protection Agency; National Park Service
[H2370094000]
FX IMPROVE and CSN data are available for download
(http://vista.cira.colostate.edu/improve and
http://views.cira.colostate.edu/fed, respectively). Derived results are
available from the authors. IMPROVE is a collaborative association of
state, tribal, and federal agencies, and international partners. The
U.S. Environmental Protection Agency is the primary funding source, with
contracting and research support from the National Park Service. The Air
Quality Group at the University of California, Davis, is the central
analytical laboratory, with ion analysis provided by Research Triangle
Institute and carbon analysis provided by Desert Research Institute.
This work was funded by the National Park Service under contract
H2370094000. The assumptions, findings, conclusions, judgments, and
views presented herein are those of the authors and should not be
interpreted as necessarily representing the National Park Service
policies.
NR 67
TC 4
Z9 4
U1 5
U2 26
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD NOV 27
PY 2014
VL 119
IS 22
BP 12832
EP 12849
DI 10.1002/2014JD022328
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AW5YA
UT WOS:000346345600024
ER
PT J
AU Kim, YH
Boykin, E
Stevens, T
Lavrich, K
Gilmour, MI
AF Kim, Yong Ho
Boykin, Elizabeth
Stevens, Tina
Lavrich, Katelyn
Gilmour, M. Ian
TI Comparative lung toxicity of engineered nanomaterials utilizing in
vitro, ex vivo and in vivo approaches
SO JOURNAL OF NANOBIOTECHNOLOGY
LA English
DT Article
DE Engineered nanomaterials; Lung toxicity; Alternative toxicity testing
ID CERIUM OXIDE NANOPARTICLES; TITANIUM-DIOXIDE; INTRATRACHEAL
INSTILLATION; PULMONARY INFLAMMATION; HAZARD IDENTIFICATION; PARTICULATE
MATTER; OXIDATIVE STRESS; ZINC-OXIDE; DOSIMETRY; EXPOSURE
AB Background: Although engineered nanomaterials (ENM) are currently regulated either in the context of a new chemical, or as a new use of an existing chemical, hazard assessment is still to a large extent reliant on information from historical toxicity studies of the parent compound, and may not take into account special properties related to the small size and high surface area of ENM. While it is important to properly screen and predict the potential toxicity of ENM, there is also concern that current toxicity tests will require even heavier use of experimental animals, and reliable alternatives should be developed and validated. Here we assessed the comparative respiratory toxicity of ENM in three different methods which employed in vivo, in vitro and ex vivo toxicity testing approaches.
Methods: Toxicity of five ENM (SiO2 (10), CeO2 (23), CeO2 (88), TiO2 (10), and TiO2 (200); parentheses indicate average ENM diameter in nm) were tested in this study. CD-1 mice were exposed to the ENM by oropharyngeal aspiration at a dose of 100 mu g. Mouse lung tissue slices and alveolar macrophages were also exposed to the ENM at concentrations of 22-132 and 3.1-100 mu g/mL, respectively. Biomarkers of lung injury and inflammation were assessed at 4 and/or 24 hr post-exposure.
Results: Small-sized ENM (SiO2 (10), CeO2 (23), but not TiO2 (10)) significantly elicited pro-inflammatory responses in mice (in vivo), suggesting that the observed toxicity in the lungs was dependent on size and chemical composition. Similarly, SiO2 (10) and/or CeO2 (23) were also more toxic in the lung tissue slices (ex vivo) and alveolar macrophages (in vitro) compared to other ENM. A similar pattern of inflammatory response (e. g., interleukin-6) was observed in both ex vivo and in vitro when a dose metric based on cell surface area (mu g/cm(2)), but not culture medium volume (mu g/mL) was employed.
Conclusion: Exposure to ENM induced acute lung inflammatory effects in a size- and chemical composition-dependent manner. The cell culture and lung slice techniques provided similar profiles of effect and help bridge the gap in our understanding of in vivo, ex vivo, and in vitro toxicity outcomes.
C1 [Kim, Yong Ho; Lavrich, Katelyn] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Boykin, Elizabeth; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Stevens, Tina] US EPA, Res Triangle Pk Div, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM gilmour.ian@epa.gov
FU EPA-UNC Toxicology Training Agreement [CR-83515201-0]; Curriculum in
Toxicology, University of North Carolina at Chapel Hill
FX We thank Debora Andrews, Judy Richards, and Richard Jaskot for technical
assistance in toxicologic analyses and Drs. Kevin Dreher and James Samet
for their review of this manuscript. The project was supported by grant
from the EPA-UNC Toxicology Training Agreement (CR-83515201-0), with the
Curriculum in Toxicology, University of North Carolina at Chapel Hill.
This paper has been reviewed by the National Health and Environmental
Effects Research Laboratory, U.S. Environmental Protection Agency, and
approved for publication. Approval does not signify that contents
necessarily reflect the views and polices of Agency, nor does the
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 48
TC 5
Z9 5
U1 1
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-3155
J9 J NANOBIOTECHNOL
JI J. Nanobiotechnol.
PD NOV 26
PY 2014
VL 12
AR 47
DI 10.1186/s12951-014-0047-3
PG 12
WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
SC Biotechnology & Applied Microbiology; Science & Technology - Other
Topics
GA AW7HK
UT WOS:000346435100001
PM 25424549
ER
PT J
AU Arnold, KE
Brown, AR
Ankley, GT
Sumpter, JP
AF Arnold, Kathryn E.
Brown, A. Ross
Ankley, Gerald T.
Sumpter, John P.
TI Medicating the environment: assessing risks of pharmaceuticals to
wildlife and ecosystems
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Editorial Material
DE pharmaceuticals; ecotoxicology; sewage; population ecology;
contaminants; environmental risk assessment
ID PERSONAL CARE PRODUCTS; RELEVANT CONCENTRATIONS; PIMEPHALES-PROMELAS;
FATHEAD MINNOWS; GYPS VULTURES; FISH; EXPOSURE; ANTIDEPRESSANTS;
DICLOFENAC; FLUOXETINE
AB Global pharmaceutical consumption is rising with the growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in a wide range of ecosystems and organisms. Environmental concentrations are often low, but pharmaceuticals typically are designed to have biological effects at low doses, acting on physiological systems that can be evolutionarily conserved across taxa. This Theme Issue introduces the latest research investigating the risks of environmentally relevant concentrations of pharmaceuticals to vertebrate wildlife. We take a holistic, global view of environmental exposure to pharmaceuticals encompassing terrestrial, freshwater and marine ecosystems in high- and low-income countries. Based on both field and laboratory data, the evidence for and relevance of changes to physiology and behaviour, in addition to mortality and reproductive effects, are examined in terms of the population- and community-level consequences of pharmaceutical exposure on wildlife. Studies on uptake, trophic transfer and indirect effects of pharmaceuticals acting via food webs are presented. Given the logistical and ethical complexities of research in this area, several papers focus on techniques for prioritizing which compounds are most likely to harm wildlife and how modelling approaches can make predictions about the bioavailability, metabolism and toxicity of pharmaceuticals in non-target species. This Theme Issue aims to help clarify the uncertainties, highlight opportunities and inform ongoing scientific and policy debates on the impacts of pharmaceuticals in the environment.
C1 [Arnold, Kathryn E.] Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
[Brown, A. Ross] AstraZeneca Safety, Hlth & Environm, Brixham Environm Lab, Brixham, Devon, England.
[Brown, A. Ross] Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England.
[Ankley, Gerald T.] US EPA, Duluth, MN 55804 USA.
[Sumpter, John P.] Brunel Univ, Inst Environm, Uxbridge UB8 3PH, Middx, England.
RP Arnold, KE (reprint author), Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
EM kathryn.arnold@york.ac.uk
RI PRAZERES, KELLY/O-7715-2015; Arnold, Kathryn/F-8683-2016
OI Arnold, Kathryn/0000-0002-6485-6065
NR 92
TC 32
Z9 32
U1 23
U2 182
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD NOV 19
PY 2014
VL 369
IS 1656
AR 20130569
DI 10.1098/rstb.2013.0569
PG 11
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AQ8VK
UT WOS:000343114500001
ER
PT J
AU LaLone, CA
Berninger, JP
Villeneuve, DL
Ankley, GT
AF LaLone, Carlie A.
Berninger, Jason P.
Villeneuve, Daniel L.
Ankley, Gerald T.
TI Leveraging existing data for prioritization of the ecological risks of
human and veterinary pharmaceuticals to aquatic organisms
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Review
DE pharmacokinetics; SeqAPASS; adverse outcome pathway; read-across;
molecular target conservation
ID MINNOW PIMEPHALES-PROMELAS; MEDAKA ORYZIAS-LATIPES; DOPAMINE-RECEPTOR
ANTAGONIST; TERM REPRODUCTION ASSAY; MALE FATHEAD MINNOWS; EARLY-LIFE
STAGES; JAPANESE MEDAKA; OREOCHROMIS-NILOTICUS; CURRENT PERSPECTIVES;
GENE-EXPRESSION
AB Medicinal innovation has led to the discovery and use of thousands of human and veterinary drugs. With this comes the potential for unintended effects on non-target organisms exposed to pharmaceuticals inevitably entering the environment. The impracticality of generating whole-organism chronic toxicity data representative of all species in the environment has necessitated prioritization of drugs for focused empirical testing as well as field monitoring. Current prioritization strategies typically emphasize likelihood for exposure (i.e. predicted/measured environmental concentrations), while incorporating only rather limited consideration of potential effects of the drug to non-target organisms. However, substantial mammalian pharmacokinetic and mechanism/mode of action (MOA) data are produced during drug development to understand drug target specificity and efficacy for intended consumers. An integrated prioritization strategy for assessing risks of human and veterinary drugs would leverage available pharmacokinetic and toxicokinetic data for evaluation of the potential for adverse effects to non-target organisms. In this reiview, we demonstrate the utility of read-across approaches to leverage mammalian absorption, distribution, metabolism and elimination data; analyse cross-species molecular target conservation and translate therapeutic MOA to an adverse outcome pathway(s) relevant to aquatic organisms as a means to inform prioritization of drugs for focused toxicity testing and environmental monitoring.
C1 [LaLone, Carlie A.] Univ Minnesota, Coll Food Agr & Nat Resource Sci, Water Resources Ctr, St Paul, MN 55108 USA.
[LaLone, Carlie A.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Berninger, Jason P.] CNR, Duluth, MN 55804 USA.
RP LaLone, CA (reprint author), Univ Minnesota, Coll Food Agr & Nat Resource Sci, Water Resources Ctr, 1985 Buford Ave, St Paul, MN 55108 USA.
EM lalone.carlie@epa.gov
RI Berninger, Jason/O-2401-2016
OI Berninger, Jason/0000-0003-3045-7899
NR 92
TC 11
Z9 11
U1 4
U2 38
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD NOV 19
PY 2014
VL 369
IS 1656
AR 20140022
DI 10.1098/rstb.2014.0022
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AQ8VK
UT WOS:000343114500017
ER
PT J
AU Phillips, MB
Yoon, MY
Young, B
Tan, YM
AF Phillips, Martin B.
Yoon, Miyoung
Young, Bruce
Tan, Yu-Mei
TI Analysis of biomarker utility using a PBPK/PD model for carbaryl
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE carbaryl; PBPK; biomarkers; biomarkers of exposure; biomarkers of
effect; computational toxicology
ID EXPOSURE ASSESSMENT; BIOMONITORING DATA; SUPPORT EXPOSURE; SENSITIVITY;
PESTICIDES; HUMANS
AB There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker concentrations and exposure/effects. In the current study, a combined exposure and physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model of carbaryl was used to demonstrate the use of computational modeling for providing insight into the selection of biomarkers for different purposes. The Cumulative and Aggregate Risk Evaluation System (CARES) was used to generate exposure profiles, including magnitude and timing, for use as inputs to the PBPK/PD model. The PBPK/PD model was then used to predict blood concentrations of carbaryl and urine concentrations of its principal metabolite, 1-naphthol (1-N), as biomarkers of exposure. The PBPK/PD model also predicted acetylcholinesterase (AChE) inhibition in red blood cells (RBC) as a biomarker of effect. The correlations of these simulated biomarker concentrations with intake doses or brain AChE inhibition (as a surrogate of effects) were analyzed using a linear regression model. Results showed that 1-N in urine is a better biomarker of exposure than carbaryl in blood, and that 1-N in urine is correlated with the dose averaged over the last 2 days of the simulation. They also showed that RBC AChE inhibition is an appropriate biomarker of effect. This computational approach can be applied to a wide variety of chemicals to facilitate quantitative analysis of biomarker utility.
C1 [Phillips, Martin B.] US EPA, Natl Exposure Res Lab, Duluth, MN USA.
[Yoon, Miyoung] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC USA.
[Young, Bruce] Bayer CropSci, Res Triangle Pk, NC USA.
[Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Tan, YM (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr,Mail Code E205-01, Res Triangle Pk, NC 27711 USA.
EM tan.cecilia@epa.gov
OI Phillips, Martin/0000-0002-6282-529X; Yoon, Miyoung/0000-0002-3653-3488
FU Oak Ridge Institute for Science and Education (ORISE)
FX Dr. Martin Phillips was funded by a post-doctoral fellowship through the
Oak Ridge Institute for Science and Education (ORISE).
NR 28
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Z9 2
U1 1
U2 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 18
PY 2014
VL 5
AR 246
DI 10.3389/fphar.2014.00246
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AX8IJ
UT WOS:000347153000001
PM 25477820
ER
PT J
AU Landis, MS
Ryan, JV
ter Schure, AFH
Laudal, D
AF Landis, Matthew S.
Ryan, Jeffrey V.
ter Schure, Arnout F. H.
Laudal, Dennis
TI Behavior of Mercury Emissions from a Commercial Coal-Fired Power Plant:
The Relationship between Stack Speciation and Near-Field Plume
Measurements
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID REACTIVE GASEOUS MERCURY; PHOTOLYTIC REDUCTION; ATMOSPHERIC MERCURY; WET
DEPOSITION; EASTERN OHIO; AMBIENT AIR; HG(II); OXIDATION; AEROSOLS
AB The reduction of divalent gaseous mercury (Hg-II) to elemental gaseous mercury (Hg-0) in a commercial coal-fired power plant (CFPP) exhaust plume was investigated by simultaneous measurement in-stack and in-plume as part of a collaborative study among the U.S. EPA, EPRI, EERC, and Southern Company. In-stack continuous emission monitoring data were used to establish the CFPP's real-time mercury speciation and plume dilution tracer species (SO2, NOX) emission rates, and an airship was utilized as an airborne sampling platform to maintain static position with respect to the exhaust plume centerline for semicontinuous measurement of target species. Varying levels of Hg-II concentration (2.39-3.90 mu g m(-3)) and percent abundance (similar to 87-99%) in flue gas and in-plume reduction were observed. The existence and magnitude of Hg-II reduction to Hg-0 (0-55%) observed varied with respect to the types and relative amounts of coals combusted, suggesting that exhaust plume reduction occurring downwind of the CFPP is influenced by coal chemical composition and characteristics.
C1 [Landis, Matthew S.; Ryan, Jeffrey V.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[ter Schure, Arnout F. H.] Elect Power Res Inst, Palo Alto, CA 94304 USA.
[Laudal, Dennis] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA.
RP Landis, MS (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
EM landis.matthew@epa.gov
RI Landis, Matthew/P-5149-2014
OI Landis, Matthew/0000-0002-8742-496X
FU United States Environmental Protection Agency through Office of Research
and Development through Advanced Monitoring Initiative
FX The United States Environmental Protection Agency through its Office of
Research and Development funded this research partially through an
Advanced Monitoring Initiative Grant. It has been subjected to Agency
review and approved for publication. Mention of trade names or
commercial products do not constitute an endorsement or recommendation
for use. We thank John Jansen and Justin Walters (Southern Company), and
Dwain Waters (Gulf Power) in particular for access to the Crist Plant
and collaboration with the project; Airship Management Services (AMS)
and Integrated Systems Solutions Incorporated (ISSI) for airship
operations and logistical support; Ed Brown (EPA) for Hg measurement
support; Mike Wheeler (Alion) and Chris Winterrowd (ARCADIS) for
instrument calibration support; and Jane Caffery (University of West
Florida) for providing laboratory space and hosting our Sodar system. We
also thank Eric Edgerton from Atmospheric Research and Analysis, and
Leonard Levin from EPRI for their contributions to this project.
NR 32
TC 12
Z9 13
U1 6
U2 48
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 18
PY 2014
VL 48
IS 22
BP 13540
EP 13548
DI 10.1021/es500783t
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AT9RC
UT WOS:000345262900062
PM 25325168
ER
PT J
AU Cui, YX
Palii, SS
Innes, CL
Paules, RS
AF Cui, Yuxia
Palii, Stela S.
Innes, Cynthia L.
Paules, Richard S.
TI Depletion of ATR selectively sensitizes ATM-deficient human mammary
epithelial cells to ionizing radiation and DNA-damaging agents
SO CELL CYCLE
LA English
DT Article
DE ATM and Rad3-related (ATR); DNA damage response; G(2); M checkpoint;
ionizing radiation; synthetic lethality
ID EARLY EMBRYONIC LETHALITY; CANCER-CELLS; TARGETING ATR;
ATAXIA-TELANGIECTASIA; INDUCED AUTOPHAGY; G(2) CHECKPOINT; TUMOR-CELLS;
INHIBITION; APOPTOSIS; RESISTANCE
AB DNA damage response (DDR) to double strand breaks is coordinated by 3 phosphatidylinositol 3-kinase-related kinase (PIKK) family members: the ataxia-telangiectasia mutated kinase (ATM), the ATM and Rad3-related (ATR) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). ATM and ATR are central players in activating cell cycle checkpoints and function as an active barrier against genome instability and tumorigenesis in replicating cells. Loss of ATM function is frequently reported in various types of tumors, thus placing more reliance on ATR for checkpoint arrest and cell survival following DNA damage. To investigate the role of ATR in the G(2)/M checkpoint regulation in response to ionizing radiation (IR), particularly when ATM is deficient, cell lines deficient of ATM, ATR, or both were generated using a doxycycline-inducible lentiviral system. Our data suggests that while depletion of ATR or ATM alone in wild-type human mammary epithelial cell cultures (HME-CCs) has little effect on radiosensitivity or IR-induced G2/M checkpoint arrest, depletion of ATR in ATM-deficient cells causes synthetic lethality following IR, which correlates with severe G(2)/M checkpoint attenuation. ATR depletion also inhibits IR-induced autophagy, regardless of the ATM status, and enhances IR-induced apoptosis particularly when ATM is deficient. Collectively, our results clearly demonstrate that ATR function is required for the IR-induced G(2)/M checkpoint activation and subsequent survival of cells with ATM deficiency. The synthetic lethal interaction between ATM and ATR in response to IR supports ATR as a therapeutic target for improved anti-cancer regimens, especially in tumors with a dysfunctional ATM pathway.
C1 [Cui, Yuxia; Palii, Stela S.; Innes, Cynthia L.; Paules, Richard S.] Natl Inst Hlth Res, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Paules, RS (reprint author), Natl Inst Hlth Res, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
EM paules@niehs.nih.gov
FU NIH, National Institute of Environmental Health Sciences [Z01ES021157]
FX This research was supported by the Intramural Research Program of the
NIH, National Institute of Environmental Health Sciences (Z01ES021157).
NR 43
TC 2
Z9 2
U1 0
U2 3
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD NOV 15
PY 2014
VL 13
IS 22
BP 3541
EP 3550
DI 10.4161/15384101.2014.960729
PG 10
WC Cell Biology
SC Cell Biology
GA AZ6KM
UT WOS:000348328800013
PM 25483091
ER
PT J
AU Cantrell, SA
Molina, M
Lodge, DJ
Rivera-Figueroa, FJ
Ortiz-Hernandez, ML
Marchetti, AA
Cyterski, MJ
Perez-Jimenez, JR
AF Cantrell, Sharon A.
Molina, Marirosa
Lodge, D. Jean
Rivera-Figueroa, Francisco J.
Ortiz-Hernandez, Maria L.
Marchetti, Albany A.
Cyterski, Mike J.
Perez-Jimenez, Jose R.
TI Effects of a simulated hurricane disturbance on forest floor microbial
communities
SO FOREST ECOLOGY AND MANAGEMENT
LA English
DT Article
DE Soil and leaf litter microbial communities; Canopy opening; Debris
addition; Green leaves; Senesced leaves; Spatiotemporal variations
ID PUERTO-RICO; TROPICAL FORESTS; CLIMATE-CHANGE; WET FOREST; SOIL;
DIVERSITY; BIOMASS; DECOMPOSITION; STABILITY; RESPONSES
AB Forest floor microbial communities play a critical role in the processes of decomposition and nutrient cycling. The impact of cultivation, contamination, fire, and land management on soil microbial communities have been studied but there are few studies of microbial responses to the effects of tropical storms. The Canopy Trimming Experiment was executed in the Luquillo Experimental Forest of Puerto Rico to decouple two prominent effects of a hurricane-canopy opening and debris deposition on the forest floor-on forest biota and processes. We studied the independent and interactive hurricane effects of canopy openness and debris deposition on the relative abundance and diversity of microorganisms in soil and leaf litter using ester link fatty acids methyl esters (EL-FAME) analysis, and terminal restriction fragment length polymorphism (TRFLP) profile. Non-metric multi-dimensional scaling analysis of soil FAME showed soil microbial community composition was significantly different between pre- and post-hurricane periods including in the unmanipulated plots and among blocks, but there was no significant separation among treatments. This shows that there are strong spatiotemporal dynamics in the structure of soil microbial communities which masked hurricane effects (canopy opening and deposition of green debris). The degree of difference among treatments decreased with time in soil which suggests that our study may have started too late after the manipulations and therefore missed the effects of canopy opening and debris addition. This reflects the resilience of the soil microbial communities. The richness of soil bacterial TRF's however, showed a significant positive response to added debris. Neither fungal nor bacterial NMDS clusters for leaf microbial communities showed significant grouping by treatment, time or litter cohorts. Significant differences were observed through time for fungal diversity in green leaves and for both bacterial and fungal diversity in senesced leaves. Senesced leaves microbial succession apparently stopped when both the canopy and debris were removed, and there was a suggestive trimming by time interaction which reflects the susceptibility of the leaf litter microbial community. Our findings contribute to the understanding of how microbial community structures can be affected by hurricane disturbances and forestry management practices that remove canopy and debris from the forest floor, and shows the need to analyze the microbial community immediately after the disturbance. Short-term changes in microbial communities due to forest disturbances can have significant implications for litter decomposition, soil organic matter accumulation, nutrient cycling, and food web dynamics in tropical forests. All of these factors should be taken into consideration when selecting the appropriate forest management practice. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Cantrell, Sharon A.; Rivera-Figueroa, Francisco J.; Ortiz-Hernandez, Maria L.; Perez-Jimenez, Jose R.] Univ Turabo, Dept Biol, Gurabo, PR 00778 USA.
[Molina, Marirosa; Cyterski, Mike J.] US EPA, ORD, Athens, GA 30605 USA.
[Lodge, D. Jean] USDA, Ctr Forest Mycol Res, Forest Serv, No Res Stn, Luquillo, PR 00773 USA.
[Marchetti, Albany A.] Univ Estadual Norte Fluminense, Campos Dos Goytacazes, Brazil.
RP Cantrell, SA (reprint author), Univ Turabo, Sch Sci & Technol, Dept Biol, POB 3030, Gurabo, PR 00778 USA.
EM scantrel@suagm.edu; molina.marirosa@epa.gov; djlodge@caribe.net;
frivera@suagm.edu; albanymarchetti@yahoo.com.br; ut_jperezjm@suagm.edu
FU U.S. National Science Foundation [DEB-0218039, DEB-0620910]; University
of Puerto Rico; International Institute of Tropical Forestry, USDA
Forest Service
FX This research was funded by grants DEB-0218039 and DEB-0620910 from the
U.S. National Science Foundation to the Institute for Tropical Ecosystem
Studies, University of Puerto Rico, and the International Institute of
Tropical Forestry, USDA Forest Service, as part of the Luquillo
Long-Term Ecological Research Program. We also thank A. Shiels and
anonymous reviewers for the pre-review and suggestions. Our sincere
gratitude goes to Dr. Michael Willig and Dr. Steve Presely for the help
with the statistical analysis using the program R. This paper has been
reviewed in accordance with the USEPA and USDA-Forest Service's peer and
administrative review policies and approved for publication. Mention of
trade-names or commercial products does not constitute endorsement or
recommendation for use by USEPA or USDA. This paper was prepared by US
Government employees and is thus in the public domain and not subject to
copyright.
NR 53
TC 6
Z9 6
U1 3
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1127
EI 1872-7042
J9 FOREST ECOL MANAG
JI For. Ecol. Manage.
PD NOV 15
PY 2014
VL 332
BP 22
EP 31
DI 10.1016/j.foreco.2014.07.010
PG 10
WC Forestry
SC Forestry
GA AY5EK
UT WOS:000347595700003
ER
PT J
AU Stahl, LL
Snyder, BD
Olsen, AR
Kincaid, TM
Wathen, JB
McCarty, HB
AF Stahl, Leanne L.
Snyder, Blame D.
Olsen, Anthony R.
Kincaid, Thomas M.
Wathen, John B.
McCarty, Harry B.
TI Perfluorinated compounds in fish from US urban rivers and the Great
Lakes
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Fish tissue; Perfluorinated compounds; Urban rivers; Great Lakes;
Probabilistic survey
ID PERFLUOROALKYL CONTAMINANTS; POLYFLUOROALKYL SUBSTANCES; PERFLUOROOCTANE
SULFONATE; ORGANIC-COMPOUNDS; HUMAN BLOOD; SERUM; ACIDS; TROUT; CHAIN;
PFOA
AB Perfluorinated compounds (PFCs) have recently received scientific and regulatory attention due to their broad environmental distribution, persistence, bioaccumulative potential, and toxicity. Studies suggest that fish consumption may be a source of human exposure to perfluorooctane sulfonate (PFOS) or long-chain perfluorocarboxylic acids. Most PFC fish tissue literature focuses on marine fish and waters outside of the United States (U.S.). To broaden assessments in U.S. fish, a characterization of PFCs in freshwater fish was initiated on a national scale using an unequal probability design during the U.S. Environmental Protection Agency's (EPA's) 2008-2009 National Rivers and Streams Assessment (NRSA) and the Great Lakes Human Health Fish Tissue Study component of the 2010 EPA National Coastal Condition Assessment (NCCA/GL). Fish were collected from randomly selected locations-164 urban river sites and 157 nearshore Great Lake sites. The probability design allowed extrapolation to the sampled population of 17,059 km in urban rivers and a nearshore area of 11,091 km(2) in the Great Lakes. Fillets were analyzed for 13 PFCs using high-performance liquid chromatography tandem mass spectrometry. Results showed that PFOS dominated in frequency of occurrence, followed by three other longer-chain PFCs (perfluorodecanoic acid, perfluoroundecanoic acid, and perfluorododecanoic acid). Maximum PFOS concentrations were 127 and 80 ng/g in urban river samples and Great Lakes samples, respectively. The range of NRSA PFOS detections was similar to literature accounts from targeted riverine fish sampling. NCCA/GL PFOS levels were lower than those reported by other Great Lakes researchers, but generally higher than values in targeted inland lake studies. The probability design allowed development of cumulative distribution functions (CDFs) to quantify PFOS concentrations versus the sampled population, and the application of fish consumption advisory guidance to the CDFs resulted in an estimation of the proportion of urban rivers and the Great Lakes that exceed human health protection thresholds. (C) 2014 Published by Elsevier B.V.
C1 [Stahl, Leanne L.; Wathen, John B.] US EPA, OW Off Sci & Technol, Washington, DC 20460 USA.
[Snyder, Blame D.] Tetra Tech Inc, Ctr Ecol Sci, Owings Mills, MD 21117 USA.
[Olsen, Anthony R.; Kincaid, Thomas M.] ORD Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[McCarty, Harry B.] CSC, Alexandria, VA 22310 USA.
RP Stahl, LL (reprint author), US EPA, OW Off Sci & Technol, 1200 Penn Ave,NW MC 4305, Washington, DC 20460 USA.
EM stahl.leanne@epa.gov; blaine.snyder@tetratech.com; olsen.tony@epa.gov;
kincaid.tom@epa.gov; wathen.john@epa.gov; hmccarty@csc.com
FU U.S. Environmental Protection Agency; EPA [EP-C-04-030, EP-C-06-085,
EP-C-09-019, EP-C-10-060]
FX This study was funded by the U.S. Environmental Protection Agency, and
technical support was provided under EPA Contracts EP-C-04-030,
EP-C-06-085, EP-C-09-019, and EP-C-10-060. The manuscript has been
subjected to review and approved for publication by U.S. EPA's Office of
Research and Development and EPA's Office of Water. Approval does not
signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 65
TC 8
Z9 9
U1 8
U2 88
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 15
PY 2014
VL 499
BP 185
EP 195
DI 10.1016/j.scitotenv.2014.07.126
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GN
UT WOS:000343613200020
PM 25190044
ER
PT J
AU Wallis, LK
Diamond, SA
Ma, HB
Hoff, DJ
Al-Abed, SR
Li, SB
AF Wallis, Lindsay K.
Diamond, Stephen A.
Ma, Hongbo
Hoff, Dale J.
Al-Abed, Souhail R.
Li, Shibin
TI Chronic TiO2 nanoparticle exposure to a benthic organism, Hyalella
azteca: impact of solar UV radiation and material surface coatings on
toxicity
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Nano-TiO2; Chronic toxicity; Phototoxicity; Hyalella azteca; Growth
ID TITANIUM-DIOXIDE NANOPARTICLES; DAPHNIA-MAGNA; PHOTOTOXICITY;
ENVIRONMENT; SUNSCREENS; NANOMATERIALS; IRRADIATION; NANO-TIO2;
AMPHIPOD; WATER
AB There is limited information on the chronic effects of nanomaterials to benthic organisms, as well as environmental mitigating factors that might influence this toxicity. The present study aimed to fill these data gaps by examining various growth endpoints (weight gain, instantaneous growth rate, and total protein content) for up to a 21 d sediment exposure of TiO2 nanoparticles (nano-TiO2) to a representative benthic species, Hyalella azteca. An uncoated standard, P25, and an Al(OH)(3) coated nano-TiO2 used in commercial products were added to sediment at 20 mg/L or 100 mg/L Under test conditions, UV exposure alone was shown to be a greater cause of toxicity than even these high levels of nano-TiO2 exposure, indicating that different hazards need to be addressed in toxicity testing scenarios. In addition, this study showed the effectiveness of a surface coating on the decreased photoactivity of the material, as the addition of an Al(OH)(3) coating showed a dramatic decrease in reactive oxygen species (ROS) production. However, this reduced photoactivity was found to be partially restored when the coating had been degraded, leading to the need for future toxicity tests which examine the implications of weathering events on particle surface coatings. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wallis, Lindsay K.; Hoff, Dale J.; Li, Shibin] US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
[Diamond, Stephen A.] Nanosafe Inc, Blacksburg, VA USA.
[Ma, Hongbo] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53211 USA.
[Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Li, SB (reprint author), 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM lishibinepa@gmail.com
NR 41
TC 6
Z9 6
U1 6
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 15
PY 2014
VL 499
BP 356
EP 362
DI 10.1016/j.scitotenv.2014.08.068
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GN
UT WOS:000343613200037
PM 25203828
ER
PT J
AU Yu, SC
Alapaty, K
Mathur, R
Pleim, J
Zhang, YH
Nolte, C
Eder, B
Foley, K
Nagashima, T
AF Yu, Shaocai
Alapaty, Kiran
Mathur, Rohit
Pleim, Jonathan
Zhang, Yuanhang
Nolte, Chris
Eder, Brian
Foley, Kristen
Nagashima, Tatsuya
TI Attribution of the United States "warming hole'': Aerosol indirect
effect and precipitable water vapor
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CLIMATE RESPONSE; ANTHROPOGENIC AEROSOLS; MODEL; 20TH-CENTURY;
TEMPERATURE; SYSTEM; CMIP5; SIMULATIONS; VARIABILITY; RADIATION
AB Aerosols can influence the climate indirectly by acting as cloud condensation nuclei and/or ice nuclei, thereby modifying cloud optical properties. In contrast to the widespread global warming, the central and south central United States display a noteworthy overall cooling trend during the 20th century, with an especially striking cooling trend in summertime daily maximum temperature (T-max) (termed the U.S. "warming hole''). Here we used observations of temperature, shortwave cloud forcing (SWCF), longwave cloud forcing (LWCF), aerosol optical depth and precipitable water vapor as well as global coupled climate models to explore the attribution of the "warming hole''. We find that the observed cooling trend in summer T-max can be attributed mainly to SWCF due to aerosols with offset from the greenhouse effect of precipitable water vapor. A global coupled climate model reveals that the observed "warming hole'' can be produced only when the aerosol fields are simulated with a reasonable degree of accuracy as this is necessary for accurate simulation of SWCF over the region. These results provide compelling evidence of the role of the aerosol indirect effect in cooling regional climate on the Earth. Our results reaffirm that LWCF can warm both winter T-max and T-min.
C1 [Yu, Shaocai] Zhejiang Univ, Coll Environm & Resource Sci, Res Ctr Air Pollut & Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
[Alapaty, Kiran; Mathur, Rohit; Pleim, Jonathan; Nolte, Chris; Eder, Brian; Foley, Kristen] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Zhang, Yuanhang] Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China.
[Nagashima, Tatsuya] Natl Inst Environm Studies, Tsukuba, Ibaraki 3058506, Japan.
RP Yu, SC (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Res Ctr Air Pollut & Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
EM shaocaiyu@zju.edu.cn
RI Zhang, Yuanhang/F-7038-2011; Nolte, Christopher/H-4345-2012; yu,
shaocai/G-7806-2011; yu, shaocai/F-1394-2014; Pleim, Jonathan
Pleim/C-1331-2017
OI Nolte, Christopher/0000-0001-5224-9965; Pleim, Jonathan
Pleim/0000-0001-6190-6082
FU United States Environmental Protection Agency through Office of Research
and Development; Zhejiang 1,000 Talent Plan; Research Center for Air
Pollution and Health in Zhejiang University
FX We thank Prof. Susan Solomon for insightful discussions that led to a
substantial strengthening of the manuscript, Prof. Daniel Rosenfeld and
Dr. Christian Hogrefe for helpful comments. We thank the CERES, GHCNM,
MODIS and WCRP CMIP5 groups for producing the data used in this paper.
The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to Agency's administrative review and approved for
publication. Analyses and visualizations used in this study were
produced with the Giovanni online data system, developed and maintained
by the NASA GES DISC. We also acknowledge the MODIS mission scientists
and associated NASA personnel for the production of the data used in
this research effort. The part of this work is supported by the
"Zhejiang 1,000 Talent Plan'' and Research Center for Air Pollution and
Health in Zhejiang University.
NR 41
TC 18
Z9 18
U1 4
U2 36
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 6
PY 2014
VL 4
AR 6929
DI 10.1038/srep06929
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS5MP
UT WOS:000344315200001
PM 25373416
ER
PT J
AU Ihlaseh-Catalano, SM
Bailey, KA
Cardoso, APF
Ren, HZ
Fry, RC
de Camargo, JLV
Wolf, DC
AF Ihlaseh-Catalano, Shadia M.
Bailey, Kathryn A.
Cardoso, Ana Paula F.
Ren, Hongzu
Fry, Rebecca C.
de Camargo, Joao Lauro V.
Wolf, Douglas C.
TI Dose and temporal effects on gene expression profiles of urothelial
cells from rats exposed to diuron
SO TOXICOLOGY
LA English
DT Article
DE Diuron; Rat urinary bladder; Carcinogenesis; Gene expression profiling;
Microarray analysis; Cell adhesion
ID URINARY-BLADDER CARCINOGENESIS; MALE WISTAR RATS; MODE; RESPONSES;
TOXICITY; CANCER; BETA
AB Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a substituted urea herbicide that at high dietary levels (2500 ppm) induces rat urinary bladder hyperplasia after 20 weeks of exposure and neoplasia after 2 years. The effects on the urothelium after short-term exposure have not been described. The present 7-day study evaluated the dose-dependency of urothelial alterations in the urinary bladder using light microscopy, scanning electron microscopy, and genome-wide transcriptional profiling. Male Wistar rats were fed 0,125, 500, 2500 ppm diuron for 7 days. The urinary bladder and isolated urothelial cells of these animals were processed for microscopic examination and gene expression profiling, respectively. No significant treatment-related morphologic effects were observed. The number of differentially expressed genes (DEGs) in the exposed groups increased with diuron levels. Diuron-altered genes involved in cell-to-cell interactions and tissue organization were identified in all treatment groups. After 7 days of diuron exposure, transcriptional responses were observed in the urothelium in the absence of clear morphologic changes. These morphological findings are different from those observed in a previous study in which 20 weeks of diuron exposure was associated with simple hyperplasia secondary to the persistent cytotoxicity and necrosis associated with continuous cellular regeneration. Comparison of the gene expression profiles of rats exposed to the 2500 ppm carcinogenic diuron dose for 7 days versus 20 weeks revealed few similarities between these two time points at the gene or pathway level. Taken together, these data provide insight into the dose- and temporal-dependent morphological and transcriptional changes associated with diuron exposure that may lead to the development of tumors in the rat urinary bladder. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Ihlaseh-Catalano, Shadia M.; Cardoso, Ana Paula F.; de Camargo, Joao Lauro V.] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618000 Botucatu, SP, Brazil.
[Bailey, Kathryn A.; Fry, Rebecca C.] UNC Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27559 USA.
[Ren, Hongzu; Wolf, Douglas C.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP de Camargo, JLV (reprint author), UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618000 Botucatu, SP, Brazil.
EM shadia.catalano@basf.com; katie.bailey@syngenta.com;
anaferragut@fmb.unesp.br; ren.hongzu@epa.gov; rfry@unc.edu;
decam@fmb.unesp.br; USA.Doug.Wolf@syngenta.com
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
[06/60506-1, 08/55644-1, 09/02754-7]; Center for the Evaluation of the
Environmental Impact on Human Health (TOXICAM, Botucatu Medical School,
Univ. Estadual Paulista); U.S. Environmental Protection Agency (U.S.
EPA); National Institute of Environmental Health Sciences (NIEHS) [T32
ES7018]
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
de Sao Paulo (FAPESP Grants No. 06/60506-1, 08/55644-1 and 09/02754-7),
Center for the Evaluation of the Environmental Impact on Human Health
(TOXICAM, Botucatu Medical School, Univ. Estadual Paulista), U.S.
Environmental Protection Agency (U.S. EPA), and the National Institute
of Environmental Health Sciences (NIEHS, T32 ES7018).
NR 26
TC 1
Z9 2
U1 3
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD NOV 5
PY 2014
VL 325
BP 21
EP 30
DI 10.1016/j.tox.2014.08.005
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA AR7UO
UT WOS:000343785400003
PM 25152437
ER
PT J
AU Shalamzari, MS
Kahnt, A
Vermeylen, R
Kleindienst, TE
Lewandowski, M
Cuyckens, F
Maenhaut, W
Claeys, M
AF Shalamzari, Mohammad Safi
Kahnt, Ariane
Vermeylen, Reinhilde
Kleindienst, Tadeusz E.
Lewandowski, Michael
Cuyckens, Filip
Maenhaut, Willy
Claeys, Magda
TI Characterization of Polar Organosulfates in Secondary Organic Aerosol
from the Green Leaf Volatile 3-Z-Hexenal
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ATMOSPHERIC AEROSOLS; MASS-SPECTROMETRY; ISOPRENE; PHOTOOXIDATION;
PHOTOLYSIS; KINETICS; DEFENSE
AB Evidence is provided That the green leaf volatiles 3-Z- hexenal serves as a precursor for biogenic secondary organic aersol through the formation of polar organosulfates (Os) with molecular weight (MW) 226. The MW 226 C-6-OSs were Chemically elucidated, along with structurally similar MW 212 C-5-OSs, whose biogenic precursor is likely related to 3-Z-hexenal but still remains unknown. The MW: 226 and 212 OSs have a substantial abundance in ambient fine aerosol from K-puszta, Hungary, which is comparable to that of the isoprene-related MW 216 OSs, known to be formed: through sulfation of C-5-epoxydiols, second-generation gas-phase photooxidation products of isoprene. Using detailed interpretation of negative-ion electrospray ionization mass spectral data, the MW 226, compounds are assigned to isomeric sulfate esters of 3,4-dihydroxyhex-5-enoic acid with the sulfate group located or C-4 position. Two MW 212 compounds present in: ambient fine aerosol are attributed to isomeric sulfate :esters of 2,3-dihydroxypent-4-enoic acid, of which two are sulfated at C-3 and one is sulfated at C-2. The formation of the MW 226 :OSs is tentatively explained through photooxidation of 3-Z-hexenal in, the gas phase, resulting in alkoxy radical, followed by a rearrangement and subsequent sulfation of the epoxy group in the particle phase.
C1 [Shalamzari, Mohammad Safi; Kahnt, Ariane; Vermeylen, Reinhilde; Maenhaut, Willy; Claeys, Magda] Univ Antwerp, Dept Pharmaceut Sci, BE-2610 Antwerp, Belgium.
[Shalamzari, Mohammad Safi; Maenhaut, Willy] Univ Ghent, Dept Analyt Chem, BE-9000 Ghent, Belgium.
[Kleindienst, Tadeusz E.; Lewandowski, Michael] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Cuyckens, Filip] Janssen Res & Dev, Drug Metab & Pharmacokinet, BE-2340 Beerse, Belgium.
RP Claeys, M (reprint author), Univ Antwerp, Dept Pharmaceut Sci, BE-2610 Antwerp, Belgium.
EM magda.claeys@uantwerpen.be
RI Maenhaut, Willy/M-3091-2013;
OI Maenhaut, Willy/0000-0002-4715-4627; Cuyckens, Filip/0000-0003-4956-1418
NR 35
TC 13
Z9 13
U1 6
U2 44
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12671
EP 12678
DI 10.1021/es503226b
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100024
PM 25271849
ER
PT J
AU Isaacs, KK
Glen, WG
Egeghy, P
Goldsmith, MR
Smith, L
Vallero, D
Brooks, R
Grulke, CM
Ozkaynak, H
AF Isaacs, Kristin K.
Glen, W. Graham
Egeghy, Peter
Goldsmith, Michael-Rock
Smith, Luther
Vallero, Daniel
Brooks, Raina
Grulke, Christopher M.
Oezkaynak, Haluk
TI SHEDS-HT: An Integrated Probabilistic Exposure Model for Prioritizing
Exposures to Chemicals with Near-Field and Dietary Sources
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CHILDRENS RESIDENTIAL EXPOSURE; SEMIVOLATILE ORGANIC-COMPOUNDS; PERSONAL
CARE PRODUCTS; COSMETIC PRODUCTS; CONSUMER PRODUCTS; RISK-ASSESSMENT;
INDOOR ENVIRONMENT; CHLORPYRIFOS; PESTICIDES; CALIFORNIA
AB United States Environmental Protection Agency (USEPA) researchers are developing a strategy for high-throughput (HT) exposure-based prioritization of chemicals under the ExpoCast program. These novel modeling approaches for evaluating chemicals based on their potential for biologically relevant human exposures will inform toxicity testing and prioritization for chemical risk assessment. Based on probabilistic methods and algorithms developed for The Stochastic Human Exposure and Dose Simulation Model for Multimedia, Multipathway Chemicals (SHEDS-MM), a new mechanistic modeling approach has been developed to accommodate high-throughput (HT) assessment of exposure potential. In this SHEDS-HT model, the residential and dietary modules of SHEDS-MM have been operationally modified to reduce the user burden, input data demands and run times of the higher-tier model, while maintaining critical features and inputs that influence exposure. The model has been implemented in R; the modeling framework links chemicals to consumer product categories or food groups (and thus exposure scenarios) to predict HT exposures and intake doess. Initially, SHEDS-HT has been applied to 2507 organic chemicals associated with consumer products and agricultural pesticides. These evaluations employ data from recent USEPA efforts to characterize usage (prevalence, frequency and magnitude), chemical composition, and exposure scenarios for a wide range of consumer products. In modeling indirect exposures from near-field sources SHEDS-HT employs a fugacity-based module to estimate concentrations in indoor environmental media. The concentration estimates, along with relevant exposure factors and human activity data, are then used by the model to rapidly generate probablistic population distributions of near-field indirect exposures via dermal. nondietary ingestion, and inhalation pathways. Pathway-specific estimates of near-field direct exposures from consumer products are also modeled. Population dietary exposures for a variety of chemicals found in foods are combined with the corresponding chemical-specific near-field exposure predictions to produce aggregate population exposure estimates. The estimated intake dose rates (mg/kg/day) for the 2507 chemical case-study spanned 13 orders of magnitude. SHEDS-HT successfully reproduced the pathway-specific exposure results of the higher-tier SHEDS-MM for a case-study pesticide and produced median intake doses significantly correlated (p<0.0001, R-2 = 0.39) with medians inferred using biomonitoring data for 39 chemicals from the National Health and Nutrition Examination Survey (NHANES). Based on the favorable performance of SHEDS-HT with respect to these initial evaluations, we believe this new tool will be useful for HT prediction of chemical exposure potential.
C1 [Isaacs, Kristin K.; Egeghy, Peter; Vallero, Daniel; Oezkaynak, Haluk] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
[Glen, W. Graham; Smith, Luther] Alion Sci & Technol, Durham, NC 27713 USA.
[Goldsmith, Michael-Rock] Chem Comp Grp, Montreal, PQ H3A 2R7, Canada.
[Brooks, Raina] US EPA, Res Triangle Pk, NC 27709 USA.
[Grulke, Christopher M.] Lockheed Martin, Res Triangle Pk, NC 27709 USA.
RP Isaacs, KK (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM isaacs.kristin@epa.gov
NR 66
TC 22
Z9 23
U1 3
U2 43
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12750
EP 12759
DI 10.1021/es502513w
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100033
PM 25222184
ER
PT J
AU Wambaugh, JF
Wang, A
Dionisio, KL
Frame, A
Egeghy, P
Judson, R
Setzer, RW
AF Wambaugh, John F.
Wang, Anran
Dionisio, Kathie L.
Frame, Alicia
Egeghy, Peter
Judson, Richard
Setzer, R. Woodrow
TI High Throughput Heuristics for Prioritizing Human Exposure to
Environmental Chemicals
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RISK-ASSESSMENT; MODELS
AB The risk posed to human health by any of the thousands of untested anthropogenic chemicals in our environment is a function of both the hazard presented by the chemical and the extent of exposure. However, many chemicals lack estimates of exposure intake, limiting the understanding of health risks. We aim to develop a rapid heuristic method to determine potential human exposure to chemicals for application to the thousands of chemicals with little or not exposure data. We used Bayesian methodology to infer ranges of exposure consistent with biomarkers identified in urine samples from the U.S. population by the National Health and Nutrition Examination Survey (NHANES). We performed linear regression on inferred exposure for demographic subsets of NHANES demarked by age, gender, and weight using chemical descriptors and use information from multiple databases and structure-based calculators. Five descriptors are capable of explaining roughly 50% of the variability in geometric means across 106 NHANES chemicals for all the demographic groups, including children aged 6-11. We use these descriptors to estimate human exposure to 7968 chemicals, the majority of which have no other quantitative exposure prediction. For thousands of chemicals with no other information, this approach allows forecasting of average exposure intake of environmental chemicals.
C1 [Wambaugh, John F.; Wang, Anran; Frame, Alicia; Judson, Richard; Setzer, R. Woodrow] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Dionisio, Kathie L.; Egeghy, Peter] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Wang, Anran] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
[Wang, Anran; Frame, Alicia] Oak Ridge Inst Sci & Educ Grantee, Oak Ridge, TN 37831 USA.
RP Wambaugh, JF (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Wambaugh.john@epa.gov
OI Judson, Richard/0000-0002-2348-9633; Wambaugh, John/0000-0002-4024-534X
NR 25
TC 21
Z9 22
U1 5
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12760
EP 12767
DI 10.1021/es503583j
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100034
PM 25343693
ER
PT J
AU Erdakos, GB
Bhave, PV
Pouliot, GA
Simon, H
Mathur, R
AF Erdakos, Garnet B.
Bhave, Prakash V.
Pouliot, George A.
Simon, Heather
Mathur, Rohit
TI Predicting the Effects of Nanoscale Cerium Additives in Diesel Fuel on
Regional-Scale Air Quality
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RISK-ASSESSMENT; EMISSIONS; PARTICULATE; PARTICLES; OXIDATION; EXPOSURE;
ENGINES
AB Diesel vehicles are a major source of air pollutant emissions. Fuel additives containing nanoparticulate cerium (nCe) are currently being used in some diesel vehicles to improve fuel efficiency. These fuel additives also reduce fine particulate matter (PM2.5) emissions and alter the emissions of carbon monoxide (CO), nitrogen oxides (NOx), and hydrocarbon (HC) species, including several hazardous air pollutants (HAPs). To predict their net effect on regional air quality, we review the emissions literature and develop a multipollutant inventory for a hypothetical scenario in which nCe additives are used in all on-road and nonroad diesel vehicles. We apply the Community Multiscale Air Quality (CMAQ) model to a domain covering the eastern U.S. for a summer and a whiter period. Model calculations suggest modest decreases of average PM2.5 concentrations and relatively larger decreases in particulate elemental carbon. The nCe additives also have an effect on 8 h maximum ozone in summer. Variable effects on HAPs are predicted. The total U.S. emissions of fine-particulate cerium are estimated to increase 25-fold and result in elevated levels of airborne cerium (up to 22 ng/m(3)), which might adversely impact human health and the environment.
C1 [Erdakos, Garnet B.; Bhave, Prakash V.; Pouliot, George A.; Mathur, Rohit] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Simon, Heather] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Erdakos, GB (reprint author), Sonoma Technol Inc, 1455 N McDowell Blvd,Suite D, Petaluma, CA 94954 USA.
EM gerdakos@sonomatech.com
RI simon, heather/E-4392-2011
OI simon, heather/0000-0001-7254-3360
NR 39
TC 3
Z9 3
U1 1
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12775
EP 12782
DI 10.1021/es504050g
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100036
PM 25271762
ER
PT J
AU Holman, E
Gray, G
AF Holman, Elizabeth
Gray, George
TI Setting Pesticide Reference Doses: A Retrospective Analysis Examining
Key Data and Choices
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE risk assessment; reference dose; science policy; pesticides
ID SAFETY ASSESSMENT; TOXICITY; RISK; CHEMICALS; HAZARD; US
AB Toxicity tests are widely used to set acceptable levels of chemical exposure. Different organizations have identified a base set of tests specifying a mix of endpoints, durations, and species to be tested. A specific test and endpoint is chosen as the basis for calculation of human health risk values like reference doses (RfDs). This study empirically evaluates the data and choices made in setting acute and chronic RfDs for 352 conventional pesticides. The results suggest that for Acute, Acute-Female Specific, and Chronic RfDs one test is used far more than others. Ninety-six percent of the 116 Acute Female-Specific RfDs relied on a developmental toxicity test and 78% of Chronic RfDs used the chronic bioassay. Tests in rats were used far more often than other species in all RfD calculations. For all types of RfDs a total uncertainty factor of 100 was most common although values as low as 1 and as high as 3000 were seen. These results provide insights not only into the science policy frameworks used, but also into ways toxicity testing and risk assessment may be streamlined and made more efficient.
C1 [Holman, Elizabeth] US EPA, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
[Holman, Elizabeth; Gray, George] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Environm & Occupat Hlth, Ctr Risk Sci & Publ Hlth, Washington, DC USA.
RP Holman, E (reprint author), US EPA, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Ariel Rios Bldg,1200 Penn Ave NW,Mail Code 7509P, Washington, DC 20460 USA.
EM Holman.Elizabeth@epamail.epa.gov
NR 36
TC 0
Z9 0
U1 0
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1080-7039
EI 1549-7860
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PD NOV 2
PY 2014
VL 20
IS 6
BP 1550
EP 1564
DI 10.1080/10807039.2013.879017
PG 15
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AE8QO
UT WOS:000334266600009
ER
PT J
AU Gladwell, W
Yost, O
Nelson, S
McCaw, Z
Gilmour, I
Ciencewicki, J
Kleeberger, S
AF Gladwell, Wesley, II
Yost, Oriana
Nelson, Spencer
McCaw, Zachary
Gilmour, Ian
Ciencewicki, Jonathan
Kleeberger, Steven
TI Differential Susceptibility to Diesel Exhaust Extract in Human
Lymphoblastoid Cell Lines
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Gladwell, Wesley, II; Yost, Oriana; Nelson, Spencer; McCaw, Zachary; Ciencewicki, Jonathan; Kleeberger, Steven] NIEHS, Res Triangle Pk, NC USA.
[Gilmour, Ian] US EPA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 125
BP S61
EP S61
DI 10.1016/j.freeradbiomed.2014.10.368
PG 1
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800145
ER
PT J
AU Verhein, KC
Nichols, JL
Panduri, V
Gladwell, W
Marzec, J
McCaw, Z
Reeves, N
Malphurs, J
Solomon, G
Wiltshire, T
Burkholder, A
Fargo, D
Bell, D
Van Houten, B
Kleeberger, SR
AF Verhein, Kirsten C.
Nichols, Jennifer L.
Panduri, Vijayalakshmi
Gladwell, Wesley
Marzec, Jacqui
McCaw, Zachary
Reeves, Nicole
Malphurs, Jason
Solomon, Greg
Wiltshire, Tim
Burkholder, Adam
Fargo, David
Bell, Douglas
Van Houten, Bennett
Kleeberger, Steven R.
TI Genetic Determinants of Oxidant-Induced Nuclear and Mitochondrial DNA
Lesions in a Neonatal Inbred Mouse Model of Acute Lung Injury
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Verhein, Kirsten C.; Panduri, Vijayalakshmi; Gladwell, Wesley; Marzec, Jacqui; McCaw, Zachary; Reeves, Nicole; Malphurs, Jason; Solomon, Greg; Burkholder, Adam; Fargo, David; Bell, Douglas; Kleeberger, Steven R.] NIEHS, Res Triangle Pk, NC USA.
[Nichols, Jennifer L.] US EPA, Washington, DC USA.
[Wiltshire, Tim] Univ North Carolina Chapel Hill, Chapel Hill, NC USA.
[Van Houten, Bennett] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 409
BP S167
EP S168
DI 10.1016/j.freeradbiomed.2014.10.058
PG 2
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800428
ER
PT J
AU Wages, PA
Silbajoris, R
Bromberg, PA
Simmons, SO
Samet, JM
AF Wages, Phillip A.
Silbajoris, Robert
Bromberg, Philip A.
Simmons, Steven O.
Samet, James M.
TI Exploring the Role of H2O2 in Zinc-Induced Cellular Oxidative Effects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Wages, Phillip A.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Silbajoris, Robert; Samet, James M.] US EPA, EPHD, NHEERL, Washington, DC USA.
[Bromberg, Philip A.] Univ N Carolina, CEMALB, Chapel Hill, NC USA.
[Simmons, Steven O.] US EPA, ISTD, NHEERL, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 377
BP S153
EP S153
DI 10.1016/j.freeradbiomed.2014.10.573
PG 1
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800396
ER
PT J
AU Doa, M
Lewis, P
Canavan, S
Gonzalez, Y
AF Doa, M.
Lewis, P.
Canavan, S.
Gonzalez, Y.
TI ChemView: Making data on chemicals publicly available
SO PHYTOPATHOLOGY
LA English
DT Meeting Abstract
CT APS-CPS Joint Meeting
CY AUG 09-13, 2014
CL Minneapolis, MN
SP APS, CPS
C1 [Doa, M.; Lewis, P.; Canavan, S.; Gonzalez, Y.] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PHYTOPATHOLOGICAL SOC
PI ST PAUL
PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA
SN 0031-949X
EI 1943-7684
J9 PHYTOPATHOLOGY
JI Phytopathology
PD NOV
PY 2014
VL 104
IS 11
SU 3
BP 33
EP 33
PG 1
WC Plant Sciences
SC Plant Sciences
GA AW5GG
UT WOS:000346303300188
ER
PT J
AU Browne, P
AF Browne, P.
TI EPA's Endocrine Disruptor Screening Program: Background and evaluation
of Tier 1 results from chemical case studies
SO PHYTOPATHOLOGY
LA English
DT Meeting Abstract
CT APS-CPS Joint Meeting
CY AUG 09-13, 2014
CL Minneapolis, MN
SP APS, CPS
C1 [Browne, P.] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYTOPATHOLOGICAL SOC
PI ST PAUL
PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA
SN 0031-949X
EI 1943-7684
J9 PHYTOPATHOLOGY
JI Phytopathology
PD NOV
PY 2014
VL 104
IS 11
SU 3
BP 144
EP 144
PG 1
WC Plant Sciences
SC Plant Sciences
GA AW5GG
UT WOS:000346303301026
ER
PT J
AU Alexis, NE
Carlsten, C
AF Alexis, Neil E.
Carlsten, Chris
TI Interplay of air pollution and asthma immunopathogenesis: A focused
review of diesel exhaust and ozone
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Review
DE Diesel exhaust particles (DEP); Ozone; Innate immune response; Allergic
inflammation; Asthma
ID OBSTRUCTIVE PULMONARY-DISEASE; ANTIOXIDANT N-ACETYLCYSTEINE; DENDRITIC
CELL MATURATION; IN-VIVO; INFLAMMATORY RESPONSE; NEUTROPHIL RESPONSE;
CYTOKINE PRODUCTION; PARTICULATE MATTER; ALLERGIC-ASTHMA; IGE PRODUCTION
AB Controlled human exposure experiments with diesel exhaust particles (DEPs) and ozone serve to illustrate the important role pollutants play in modulating both allergic mechanisms and immune responses to affect the immunopathogenesis of airway diseases such as asthma. For DEP, evidence is stronger for the exacerbation of existing asthma rather than for the development of new disease. To the extent that this enhancement occurs, the augmentation of Th2-type immunity seems to be a common element. For ozone, neutrophilic inflammation, altered immune cell phenotype and function and oxidative stress are all marked responses that likely contribute to underlying immune-inflammatory features of asthma. Evidence is also emerging that unique gene signatures and epigenetic control of immune and inflammatory-based genes are playing important roles in the magnitude of the impact ozone is having on respiratory health. Indeed, the interplay between air pollutants such as DEP and ozone and asthma immunopathogenesis is an ongoing concern in terms of understanding how exposure to these agents can lead to worsening of disease. To this end, asthmatics may be pre-disposed to the deleterious effects of pollutants like ozone, having constitutively modified host defense functions and gene signatures. Although this review has utilized DEP and ozone as example pollutants, more research is needed to better understand the interplay between air pollution in general and asthma immumopathogenesis. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Alexis, Neil E.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Dept Pediat, Chapel Hill, NC 27599 USA.
[Carlsten, Chris] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada.
[Carlsten, Chris] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada.
RP Alexis, NE (reprint author), Univ N Carolina, US EPA, Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM Neil_Alexis@med.unc.edu
NR 62
TC 10
Z9 10
U1 1
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD NOV
PY 2014
VL 23
IS 1
BP 347
EP 355
DI 10.1016/j.intimp.2014.08.009
PG 9
WC Immunology; Pharmacology & Pharmacy
SC Immunology; Pharmacology & Pharmacy
GA AX6FZ
UT WOS:000347019800045
PM 25194677
ER
PT J
AU Mitsch, WJ
Nedrich, SM
Harter, SK
Anderson, C
Nahlik, AM
Bernal, B
AF Mitsch, William J.
Nedrich, Sara M.
Harter, Sarah K.
Anderson, Christopher
Nahlik, Amanda M.
Bernal, Blanca
TI Sedimentation in created freshwater riverine wetlands: 15 years of
succession and contrast of methods
SO ECOLOGICAL ENGINEERING
LA English
DT Article
DE Freshwater marsh; Olentangy River Wetland Research Park; Sedimentation;
Erosion; Bioturbation; Horizon markers
ID SMALL CONSTRUCTED WETLANDS; RAPIDLY SUBSIDING WETLAND; FORESTED WETLAND;
SALT MARSHES; NUTRIENT ACCUMULATION; RIPARIAN WETLANDS; SOIL PARTICLES;
CANAL IMPACTS; UNITED-STATES; SELF-DESIGN
AB This study summarizes five separate sedimentation studies spanning 15 years (years 3-17 following wetland creation in 1994) of two 1 ha experimental flow-through wetlands. Included are methods and analyses of the most recent (2009-2010) comparative study that attempted to quantify both erosion and bioturbation processes. Depending on techniques used, two distinct types of sedimentation rates were estimated-gross and net sedimentation. Gross sedimentation in 2004-2005 (years 11 and 12) using sediment trap bottles was 45 kg m(-2) for 4 months during and after spring flood pulsing conditions in 2004 and 39 kg m(-2) for the same 4 months during and after steady flow conditions in 2005. Annual sediment accretion using feldspar and other horizon markers was 31.7 +/- 4.4 kg m(-2) yr(-1) (4.2 +/- 0.6 cm yr(-1)) in 1996 (year 3 after wetland creation) and 34.4 +/- 4.5 kg m(-2) yr(-1) (5.5 +/- 0.8 cm yr(-1)) in 2009 (year 16 after wetland creation). Net sedimentation using soil cores to estimate accumulation of sediments over antecedent soil horizon layers was 4.7 +/- 0.3 kg m(-2) yr(-1) (0.9 +/- 0.07 cm yr(-1)) in 2004 (year 11) and 6.0 +/- 0.4 kg m(-2) yr(-1) (0.9 +/- 0.06 cm yr(-1)) in 2009 (year 16). Net sedimentation, using estimates of sedimentation and erosion with the sediment erosion table (SET) method in 2009-2010 (years 16-17) was 3.9 +/- 6.1-9.0 kg m(-2) yr(-1) (1.3 +/- 0.8-1.4 cm yr(-1)). Bioturbation by macrofauna significantly decreased sedimentation rates during the 2009 (year 16) study. Spatial patterns, consistent among horizon marker and net sedimentation studies, showed that deep, open-water areas had higher rates of sedimentation than shallow areas with emergent vegetation, and that sedimentation rates were higher when closer to the inflow than at the outflow of these flow-through wetlands. Net sedimentation of these created riverine wetlands ranged from 1.2 cm/yr to 1.4 cm/yr, suggesting that these wetlands will accumulate about 30 cm of sediments in a little more than two decades. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Mitsch, William J.] Florida Gulf Coast Univ, Naples, FL 34112 USA.
[Nedrich, Sara M.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA.
[Harter, Sarah K.] Ohio EPA Southeast Dist Off, Logan, OH 43138 USA.
[Anderson, Christopher] Auburn Univ, Sch Forestry & Wildlife Sci, Auburn, AL 36849 USA.
[Nahlik, Amanda M.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
[Bernal, Blanca] Smithsonian Environm Res Ctr, Biogeochem Lab, Edgewater, MD 21037 USA.
RP Mitsch, WJ (reprint author), Florida Gulf Coast Univ, Everglades Wetland Res Pk, Naples, FL 34112 USA.
EM wmitsch@fgcu.edu
OI Mitsch, William/0000-0001-8348-3172
FU Society of Wetland Scientists; OARCD graduate research enhancement;
Payne; SEEDS grants; USDA NRI CSREES [2002-35102-13518]; USEPA from
Cincinnati OH [EM83329801-0]; Gulf of Mexico Program [MX95413108-0];
National Science Foundation [CBET-1033451, CBET-0829026]; Sigma Xi (Ohio
State Chapter)
FX Thanks to the many wetlanders who helped the authors in the four
separate studies summarized here; you are too numerous to mention but
your contributions to wetland science remain important. This research
was supported by several sources including Society of Wetland Scientists
student support, OARCD graduate research enhancement, Payne, and SEEDS
grants, USDA NRI CSREES Grant no. 2002-35102-13518, USEPA
Agreements-EM83329801-0 from Cincinnati OH and MX95413108-0 from Gulf of
Mexico Program, the National Science Foundation (CBET-1033451 and
CBET-0829026), and a Sigma Xi (Ohio State Chapter) Grant-In-Aid of
Research award. Thanks to Anne Mischo for an illustration on a short
time frame.
NR 55
TC 3
Z9 3
U1 4
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
EI 1872-6992
J9 ECOL ENG
JI Ecol. Eng.
PD NOV
PY 2014
VL 72
BP 25
EP 34
DI 10.1016/j.ecoleng.2014.09.116
PG 10
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA AW6NY
UT WOS:000346387300003
ER
PT J
AU Stauffer, BA
Goes, JI
Mckee, KT
Gomes, HD
Stabeno, PJ
AF Stauffer, Beth A.
Goes, Joaquim I.
Mckee, Kali T.
Gomes, Helga do Rosario
Stabeno, Phyllis J.
TI Comparison of spring-time phytoplankton community composition in two
cold years from the western Gulf of Alaska into the southeastern Bering
Sea
SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY
LA English
DT Article
DE Community composition; Phytoplankton; Climatic changes; Food webs;
Marine ecology
ID NORTH PACIFIC; FOOD WEBS; ECOSYSTEM; SHELF; VARIABILITY; ZOOPLANKTON;
TEMPERATURE; PHAEOCYSTIS; CLIMATE; ICE
AB The Bering Sea is a highly productive ecosystem providing the main oceanographic connection between the North Pacific and Arctic oceans. The atmospheric connection with the Arctic Ocean leads to seasonal sea ice formation in the Bering Sea, the areal extent and timing of retreat of which have important implications for primary productivity and phytoplankton community composition in this region. Hydrographic data from cruises and satellite sea ice and sea surface temperature data in spring 2011 and 2012 suggest classification of these years as relatively warmer and colder years, respectively. Locations in the western Gulf of Alaska (Pavlof Bay), at the north end of an eastern pass through the Aleutian Islands (Unimak Pass), and on the continental shelf of the Bering Sea (M2) were visited in both years. Stratification was apparent on the shelf in 2012, while the water column was comparatively well-mixed at other locations in both years. Phytoplankton biomass was highest in 2011 overall and specifically on the shelf in both years, while minimal biomass was measured within the well-mixed Unimak Pass in 2012. Surface phytoplankton size distributions included substantial contributions of picoplankton (< 3 mu m) in 2011 (21-35%), while micro-(20-200 mu m) and nanoplankton (3-20 mu m) comprised 79% and 95% of biomass in Pavlof Bay and at M2, respectively, in 2012. Analyses of similarity revealed spatial variability in the phytoplankton assemblages within each year (2011: R=0.588, p < 0.004; 2012: R=0.646, p < 0.004). Additionally, between-year variability had a strong and significant effect on differences between assemblages across all locations (R=0.579, p < 0.0003), likely masking differences between sites when years were grouped (R=0.134, p < 0.079). These differences were likely driven by the dominance (up to 75% in Unimak Pass) of the colonial prymnesiophyte Phaeocystis sp. at all sites in 2011, resulting in reduced community diversity, compared to more widespread abundance of large diatoms of the genera Thalassiosira, Thalassiothrix, and Chaetoceros in 2012. The current study shows that within-regime differences in phytoplankton community composition between years can be almost as great as that between locations with vastly different oceanographic settings. High between-and multi-year variability may combine with a potential overall decline in sea ice in the Bering Sea to produce significant changes in the productive base of the food web with potential cascading effects on higher, economically and ecologically important trophic levels. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Stauffer, Beth A.; Goes, Joaquim I.; Mckee, Kali T.; Gomes, Helga do Rosario] Columbia Univ, Dept Biol & Paleo Environm, Lamont Doherty Earth Observ, Palisades, NY 10964 USA.
[Stabeno, Phyllis J.] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA.
RP Stauffer, BA (reprint author), US EPA, 1200 Pennsylvania Ave, Washington, DC 20460 USA.
EM stauffer@ldeo.columbia.edu
FU National Aeronautics and Space Administration [NNX10AP10G, NNX11AP28G];
National Oceanic and Atmospheric Administration; Eco-FOCI project
FX This is BEST-BSIERP publication number 130. This work was supported by
the National Aeronautics and Space Administration (Grants # NNX10AP10G
and NNX11AP28G), and space aboard the R/V Oscar Dyson was generously
provided by the National Oceanic and Atmospheric Administration in
concert with the Eco-FOCI project. The authors thank K. Keebler for
field assistance, J.M. Rose
NR 54
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U1 1
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0967-0645
EI 1879-0100
J9 DEEP-SEA RES PT II
JI Deep-Sea Res. Part II-Top. Stud. Oceanogr.
PD NOV
PY 2014
VL 109
SI SI
BP 57
EP 70
DI 10.1016/j.dsr2.2014.03.007
PG 14
WC Oceanography
SC Oceanography
GA AU7UZ
UT WOS:000345807900006
ER
PT J
AU Milanovich, JR
Hopton, ME
AF Milanovich, Joseph R.
Hopton, Matthew E.
TI Stoichiometry of a semi-aquatic plethodontid salamander: Intraspecific
variation due to location, size and diet
SO INTEGRATIVE ZOOLOGY
LA English
DT Article
DE carbon; Eurycea cirrigera; nitrogen; phosphorus; stream
ID ECOSYSTEM PROCESSES; HEADWATER STREAMS; TROPICAL STREAM;
STABLE-ISOTOPES; MIXING MODELS; NEW-HAMPSHIRE; NUTRIENT; POPULATIONS;
AMPHIBIANS; DYNAMICS
AB Ecological stoichiometry provides a framework to investigate an organism's relationship to nutrient cycles. An organism's stoichiometry is thought to constrain its contribution to nutrient cycles (recycling or storage), and to limit its growth and reproduction. Factors that influence the stoichiometry of a consumer are largely unstudied, but what is known is that consumer stoichiometry is influenced by the elemental requirements of the consumer (e.g. for growth, reproduction and cell maintenance) and the availability of elements. We examined whole-body stoichiometry of larval southern two-lined salamanders (Eurycea cirrigera) and described the influence of location, body size, stoichiometry of diet items, and environmental nutrient supply on whole-body stoichiometry. Mean composition of phosphorous was 2.6%, nitrogen was 11.3%, and carbon was 39.6%, which are similar for other aquatic vertebrate taxa. The most significant predictor of whole-body stoichiometry was the site where the samples were collected, which was significant for each nutrient and nutrient ratio. Body size and stoichiometry of diet items were also predictors of Eurycea cirrigera stoichiometry. Our study suggests that spatial differences in environmental nutrient supply have a stronger influence on consumer whole-body stoichiometry among similar-sized larvae compared to life history traits, such as body size or diet.
C1 [Milanovich, Joseph R.; Hopton, Matthew E.] US EPA, Off Res & Dev, Sustainable Technol Div, Natl Risk Management Res Lab,Sustainable Environm, Cincinnati, OH 45068 USA.
RP Hopton, ME (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div,Clean Proc Branch, 26 W Martin Luther King Dr, Cincinnati, OH 45068 USA.
EM hopton.matthew@epa.gov
OI Hopton, Matt/0000-0001-7962-6820
NR 49
TC 1
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U1 4
U2 22
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1749-4877
EI 1749-4869
J9 INTEGR ZOOL
JI Integr. Zool.
PD NOV
PY 2014
VL 9
IS 5
BP 613
EP 622
DI 10.1111/1749-4877.12114
PG 10
WC Zoology
SC Zoology
GA AU6EG
UT WOS:000345695200007
PM 25236804
ER
PT J
AU Wetmore, BA
Allen, B
Clewell, HJ
Parker, T
Wambaugh, JF
Almond, LM
Sochaski, MA
Thomas, RS
AF Wetmore, Barbara A.
Allen, Brittany
Clewell, Harvey J., III
Parker, Timothy
Wambaugh, John F.
Almond, Lisa M.
Sochaski, Mark A.
Thomas, Russell S.
TI Incorporating Population Variability and Susceptible Subpopulations into
Dosimetry for High-Throughput Toxicity Testing
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE In vitro in vivo extrapolation; population variability; toxicokinetics;
reaction phenotyping; dosimetry; risk assessment
ID STATE PLASMA-CONCENTRATIONS; PHARMACOKINETIC-PHARMACODYNAMIC INTERFACE;
HUMAN LIVER-MICROSOMES; AGE-RELATED-CHANGES; IN-VITRO;
UDP-GLUCURONOSYLTRANSFERASES; RISK-ASSESSMENT; DEVELOPMENTAL EXPRESSION;
ENVIRONMENTAL CHEMICALS; EXTRAPOLATION FACTORS
AB Momentum is growing worldwide to use in vitro high-throughput screening (HTS) to evaluate human health effects of chemicals. However, the integration of dosimetry into HTS assays and incorporation of population variability will be essential before its application in a risk assessment context. Previously, we employed in vitro hepatic metabolic clearance and plasma protein binding data with in vitro in vivo extrapolation (IVIVE) modeling to estimate oral equivalent doses, or daily oral chemical doses required to achieve steady-state blood concentrations (C-ss) equivalent to media concentrations having a defined effect in an in vitro HTS assay. In this study, hepatic clearance rates of selected ToxCast chemicals were measured in vitro for 13 cytochrome P450 and five uridine 5'-diphospho-glucuronysyltransferase isozymes using recombinantly expressed enzymes. The isozyme-specific clearance rates were then incorporated into an IVIVE model that captures known differences in isozyme expression across several life stages and ethnic populations. Comparison of the median C-ss for a healthy population against the median or the upper 95th percentile for more sensitive populations revealed differences of 1.3- to 4.3-fold or 3.1- to 13.1-fold, respectively. Such values may be used to derive chemical-specific human toxicokinetic adjustment factors. The IVIVE model was also used to estimate subpopulation-specific oral equivalent doses that were directly compared with subpopulation-specific exposure estimates. This study successfully combines isozyme and physiologic differences to quantitate subpopulation pharmacokinetic variability. Incorporation of these values with dosimetry and in vitro bioactivities provides a viable approach that could be employed within a high-throughput risk assessment framework.
C1 [Wetmore, Barbara A.; Allen, Brittany; Clewell, Harvey J., III; Parker, Timothy; Sochaski, Mark A.; Thomas, Russell S.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Wambaugh, John F.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Almond, Lisa M.] Simcyp Ltd, Blades Enterprise Ctr, Sheffield S2 4SU, S Yorkshire, England.
RP Wetmore, BA (reprint author), Hamner Inst Hlth Sci, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA.
EM bwetmore@thehamner.org
OI Thomas, Russell/0000-0002-2340-0301; Wambaugh, John/0000-0002-4024-534X
FU American Chemistry Council's Long-Range Research Initiative; Agilent
Thought Leader Award, Agilent Foundation
FX American Chemistry Council's Long-Range Research Initiative; Agilent
Thought Leader Award, Agilent Foundation.
NR 91
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U1 4
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2014
VL 142
IS 1
BP 210
EP 224
DI 10.1093/toxsci/kfu169
PG 15
WC Toxicology
SC Toxicology
GA AU8IT
UT WOS:000345840600019
PM 25145659
ER
PT J
AU Breen, MS
Burke, JM
Batterman, SA
Vette, AF
Godwin, C
Croghan, CW
Schultz, BD
Long, TC
AF Breen, Michael S.
Burke, Janet M.
Batterman, Stuart A.
Vette, Alan F.
Godwin, Christopher
Croghan, Carry W.
Schultz, Bradley D.
Long, Thomas C.
TI Modeling Spatial and Temporal Variability of Residential Air Exchange
Rates for the Near-Road Exposures and Effects of Urban Air Pollutants
Study (NEXUS)
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article; Proceedings Paper
CT Conference on Integrated Science and Knowledge Co-Production for
Ecosystems and Human Well-Being
CY MAY 25-31, 2014
CL Villa Vigoni, ITALY
DE air exchange rate modeling; air pollution; health; exposure
ID CENTRAL NORTH-CAROLINA; INFILTRATION; JACKKNIFE; INDOOR; ASSESSMENTS;
BOOTSTRAP; ERROR; PM2.5; TIME
AB Air pollution health studies often use outdoor concentrations as exposure surrogates. Failure to account for variability of residential infiltration of outdoor pollutants can induce exposure errors and lead to bias and incorrect confidence intervals in health effect estimates. The residential air exchange rate (AER), which is the rate of exchange of indoor air with outdoor air, is an important determinant for house-to-house (spatial) and temporal variations of air pollution infiltration. Our goal was to evaluate and apply mechanistic models to predict AERs for 213 homes in the Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS), a cohort study of traffic-related air pollution exposures and respiratory effects in asthmatic children living near major roads in Detroit, Michigan. We used a previously developed model (LBL), which predicts AER from meteorology and questionnaire data on building characteristics related to air leakage, and an extended version of this model (LBLX) that includes natural ventilation from open windows. As a critical and novel aspect of our AER modeling approach, we performed a cross validation, which included both parameter estimation (i.e., model calibration) and model evaluation, based on daily AER measurements from a subset of 24 study homes on five consecutive days during two seasons. The measured AER varied between 0.09 and 3.48 h(-1) with a median of 0.64 h(-1). For the individual model-predicted and measured AER, the median absolute difference was 29% (0.19 h(-1)) for both the LBL and LBLX models. The LBL and LBLX models predicted 59% and 61% of the variance in the AER, respectively. Daily AER predictions for all 213 homes during the three year study (2010-2012) showed considerable house-to-house variations from building leakage differences, and temporal variations from outdoor temperature and wind speed fluctuations. Using this novel approach, NEXUS will be one of the first epidemiology studies to apply calibrated and home-specific AER models, and to include the spatial and temporal variations of AER for over 200 individual homes across multiple years into an exposure assessment in support of improving risk estimates.
C1 [Breen, Michael S.; Burke, Janet M.; Godwin, Christopher; Croghan, Carry W.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Batterman, Stuart A.; Godwin, Christopher] Univ Michigan, Ann Arbor, MI 48109 USA.
[Vette, Alan F.] US EPA, Immediate Off Assistant Administrator, Res Triangle Pk, NC 27711 USA.
[Long, Thomas C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM breen.michael@epa.gov; burke.janet@epa.gov; stuartb@umich.edu;
vette.alan@epa.gov; ccgodwin@umich.edu; croghan.carry@epa.gov;
schultz_brad@yahoo.com; long.tom@epa.gov
FU U.S. Environmental Protection Agency through Office of Research and
Development [R834117, EP-D-10-070]; NIEHS [5-R01-ES014677-02, R01
ES016769-01]
FX The NEXUS study involves a community-based participatory research
partnership, which was conducted with input from several partners,
including the Community Action Against Asthma (CAAA) Steering Committee.
We thank the CAAA its member organizations including the Arab Community
Center for Economic and Social Services, Community Health and Social
Services Center Inc., Detroit Hispanic Development Corporation,
Detroiters Working for Environmental Justice, Friends of Parkside,
Detroit Department of Health and Wellness Promotion, Latino Family
Services, Southwest Detroit Environmental Vision, Warren/Conner
Development Corporation, the University of Michigan School of Medicine,
the University of Michigan School of Public Health, and an independent
community activist. We also thank Thomas Robins and Toby Lewis, and our
field laboratory and data management staff including Leonard Brakefield,
Sonya Grant, Laprisha Berry Vaughn, Graciela Menz, and Irme Cuadros
(University of Michigan). We also thank Gary Norris for his help with
the study design, and Robert Devlin and Michelle Oakes (U.S.
Environmental Protection Agency) for their reviews and helpful
suggestions. The U.S. Environmental Protection Agency through its Office
of Research and Development partially funded the research under
cooperative agreement R834117 (University of Michigan) and contract
EP-D-10-070 (Alion Science and Technology). Although this manuscript was
reviewed by the U.S. Environmental Protection Agency and approved for
publication, it may not necessarily reflect official Agency policy. The
study was conducted as part of NIEHS grants 5-R01-ES014677-02 and R01
ES016769-01. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 38
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U1 2
U2 21
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2014
VL 11
IS 11
BP 11481
EP 11504
DI 10.3390/ijerph111111481
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AU3RT
UT WOS:000345532000028
PM 25386953
ER
PT J
AU Oakes, MM
Baxter, LK
Duvall, RM
Madden, M
Xie, MJ
Hannigan, MP
Peel, JL
Pachon, JE
Balachandran, S
Russell, A
Long, TC
AF Oakes, Michelle M.
Baxter, Lisa K.
Duvall, Rachelle M.
Madden, Meagan
Xie, Mingjie
Hannigan, Michael P.
Peel, Jennifer L.
Pachon, Jorge E.
Balachandran, Siv
Russell, Armistead
Long, Thomas C.
TI Comparing Multipollutant Emissions-Based Mobile Source Indicators to
Other Single Pollutant and Multipollutant Indicators in Different Urban
Areas
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE multipollutant; air pollution; exposure metrics; source apportionment;
mobile sources; emissions-based indicators
ID POSITIVE MATRIX FACTORIZATION; SEMIVOLATILE ORGANIC-COMPOUNDS;
AIR-QUALITY MANAGEMENT; SOURCE-APPORTIONMENT; TIME-SERIES; PARTICULATE
MATTER; AMBIENT AIR; PM2.5 CHARACTERIZATION; SPECIATION METHODS;
MEASUREMENT ERROR
AB A variety of single pollutant and multipollutant metrics can be used to represent exposure to traffic pollutant mixtures and evaluate their health effects. Integrated mobile source indicators (IMSIs) that combine air quality concentration and emissions data have recently been developed and evaluated using data from Atlanta, Georgia. IMSIs were found to track trends in traffic-related pollutants and have similar or stronger associations with health outcomes. In the current work, we apply IMSIs for gasoline, diesel and total (gasoline + diesel) vehicles to two other cities (Denver, Colorado and Houston, Texas) with different emissions profiles as well as to a different dataset from Atlanta. We compare spatial and temporal variability of IMSIs to single-pollutant indicators (carbon monoxide (CO), nitrogen oxides (NOx) and elemental carbon (EC)) and multipollutant source apportionment factors produced by Positive Matrix Factorization (PMF). Across cities, PMF-derived and IMSI gasoline metrics were most strongly correlated with CO (r = 0.31-0.98), while multipollutant diesel metrics were most strongly correlated with EC (r = 0.80-0.98). NOx correlations with PMF factors varied across cities (r = 0.29-0.67), while correlations with IMSIs were relatively consistent (r = 0.61-0.94). In general, single-pollutant metrics were more correlated with IMSIs (r = 0.58-0.98) than with PMF-derived factors (r = 0.07-0.99). A spatial analysis indicated that IMSIs were more strongly correlated (r > 0.7) between two sites in each city than single pollutant and PMF factors. These findings provide confidence that IMSIs provide a transferable, simple approach to estimate mobile source air pollution in cities with differing topography and source profiles using readily available data.
C1 [Oakes, Michelle M.; Madden, Meagan; Long, Thomas C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Oakes, Michelle M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA.
[Baxter, Lisa K.; Duvall, Rachelle M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA.
[Xie, Mingjie; Hannigan, Michael P.] Univ Colorado, Coll Engn & Appl Sci, Dept Mech Engn, Boulder, CO 80309 USA.
[Xie, Mingjie] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
[Pachon, Jorge E.] La Salle Univ, Program Environm Engn, Bogota, CO USA.
[Balachandran, Siv; Russell, Armistead] Georgia Inst Technol, Dept Civil & Environm Engn, Atlanta, GA 30332 USA.
[Balachandran, Siv] Union Concerned Scientists, Washington, DC 20006 USA.
RP Oakes, MM (reprint author), US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
EM mmoakes17@gmail.com; baxter.lisa@epa.gov; duvall.rachelle@epa.gov;
meagankmadden@gmail.com; mingjie.xie@colorado.edu;
hannigan@colorado.edu; jennifer.peel@colostate.edu;
jpachon@unisalle.edu.co; siv@gatech.edu; ted.russell@ce.gatech.edu;
long.tom@epa.gov
FU Research Participation Program in the National Center for Environmental
Assessment, Office of Research and Development, U.S. Environmental
Protection Agency
FX The authors wish to thank Michael Breen, Steven J. Dutton, Jennifer
Richmond-Bryant, Reeder Sams, and John Vandenberg for their helpful
comments in review of this manuscript. The authors also wish to thank
Alison Eyth and Adam Reff at the U.S. Environmental Protection Agency
for their help retrieving mobile source emissions data. MMO was
supported by an appointment to the Research Participation Program in the
National Center for Environmental Assessment, Office of Research and
Development, U.S. Environmental Protection Agency, administered by the
Oak Ridge Institute for Science and Education (ORISE) through an
interagency agreement between the U.S. Department of Energy and
Environmental Protection Agency. Disclaimer: The views expressed are
those of the authors and do not necessarily reflect the views or
policies of the U.S. Environmental Protection Agency.
NR 38
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U1 3
U2 30
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2014
VL 11
IS 11
BP 11727
EP 11752
DI 10.3390/ijerph111111727
PG 26
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AU3RT
UT WOS:000345532000044
PM 25405595
ER
PT J
AU Brooks, JR
Gibson, JJ
Birks, SJ
Weber, MH
Rodecap, KD
Stoddard, JL
AF Brooks, J. Renee
Gibson, John J.
Birks, S. Jean
Weber, Marc H.
Rodecap, Kent D.
Stoddard, John L.
TI Stable isotope estimates of evaporation : inflow and water residence
time for lakes across the United States as a tool for national lake
water quality assessments
SO LIMNOLOGY AND OCEANOGRAPHY
LA English
DT Article
ID PHYTOPLANKTON FUNCTIONAL-GROUPS; METEORIC PRECIPITATION; SIZE
DISTRIBUTION; NITROGEN REMOVAL; LAND-USE; RESERVOIRS; HYDROGEN; CLIMATE;
BALANCE; CANADA
AB We used water delta H-2 and delta O-18 from ca. 1000 lakes sampled in the 2007 U.S. Environmental Protection Agency's National Lakes Assessment (NLA) to assess two hydrological variables-evaporation as a percentage of inflow (E : I) and water residence time (tau) for summer 2007. Using a population survey design, sampled lakes were distributed across the conterminous U.S., and results were scaled to the inference population (similar to 50,000 U.S. lakes). These hydrologic variables were related to lake nutrients and biological condition to illustrate their usefulness in national water quality monitoring efforts. For 50% of lakes, evaporation was, 25% of inflow, with values ranging up to 113% during the 2007 summer. Residence time was, 0.52 yr for half of the lakes and, 1.12 yr for 75% of lakes. Categorizing lakes by flow regime, 66.1% of lakes were flow-though lakes (60% or more of the water flows through the lake, E : I < 0.4), 33.6% were restricted-basin lakes (40% or more of the lake inflow evaporates, 0.4 < E: I < 1), and < 0.3% were closed basin (all water entering the lake leaves through evaporation, E : I > 1). While climate patterns drove some of the spatial patterns of E : I and tau, variation in lake depth and watershed size (influencing precipitation volume) were also significant drivers. Lake hydrochemistry was strongly correlated to E: I and more weakly related to tau. Lakes in poor biological condition (based on a predictive model of planktonic taxa) were significantly more evaporated than lakes in good biological condition.
C1 [Brooks, J. Renee; Weber, Marc H.; Rodecap, Kent D.; Stoddard, John L.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Gibson, John J.] Alberta Innovates Technol Futures, Victoria, BC, Canada.
[Birks, S. Jean] Alberta Innovates Technol Futures, Calgary, AB, Canada.
RP Brooks, JR (reprint author), US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
EM Brooks.ReneeJ@epa.gov
OI Brooks, Renee/0000-0002-5008-9774; Stoddard, John/0000-0002-2537-6130;
Weber, Marc/0000-0002-9742-4744
FU U.S. EPA
FX This work was supported by the U.S. EPA. This manuscript has been
subjected to the U.S. EPA's peer and administrative review, and it has
been approved for publication as a U.S. EPA document. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 58
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U1 9
U2 44
PU AMER SOC LIMNOLOGY OCEANOGRAPHY
PI WACO
PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710-4446 USA
SN 0024-3590
EI 1939-5590
J9 LIMNOL OCEANOGR
JI Limnol. Oceanogr.
PD NOV
PY 2014
VL 59
IS 6
BP 2150
EP 2165
DI 10.4319/lo.2014.59.6.2150
PG 16
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA AU2QK
UT WOS:000345462700027
ER
PT J
AU McDonald, CP
Lottig, NR
Stoddard, JL
Herlihy, AT
Lehmann, S
Paulsen, SG
Peck, DV
Pollard, AI
Stevenson, RJ
AF McDonald, Cory P.
Lottig, Noah R.
Stoddard, John L.
Herlihy, Alan T.
Lehmann, Sarah
Paulsen, Steven G.
Peck, David V.
Pollard, Amina I.
Stevenson, R. Jan
TI Comment on Bachmann et al. (2013): A nonrepresentative sample cannot
describe the extent of cultural eutrophication of natural lakes in the
United States
SO LIMNOLOGY AND OCEANOGRAPHY
LA English
DT Article
ID FRESH-WATER; ECOSYSTEMS; PHOSPHORUS
C1 [McDonald, Cory P.] Wisconsin Dept Nat Resources, Madison, WI 53707 USA.
[Lottig, Noah R.] Univ Wisconsin, Trout Lake Res Stn, Boulder Jct, WI USA.
[Stoddard, John L.; Paulsen, Steven G.; Peck, David V.] US EPA, Western Ecol Div, Corvallis, OR USA.
[Herlihy, Alan T.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Lehmann, Sarah; Pollard, Amina I.] US EPA, Off Water, Monitoring Branch, Washington, DC 20460 USA.
[Stevenson, R. Jan] Michigan State Univ, E Lansing, MI 48824 USA.
RP McDonald, CP (reprint author), Wisconsin Dept Nat Resources, Madison, WI 53707 USA.
EM Cory.McDonald@wisconsin.gov
OI Stoddard, John/0000-0002-2537-6130; McDonald, Cory/0000-0002-1208-8471
FU Wisconsin Department of Natural Resources and the National Science
Foundation; North Temperate Lakes Long-Term Ecological Research
(Division of Environmental Biology) [DEB-0822700]; MacroSystems Biology
program (Emerging Frontiers) [EF1065818]
FX We thank the U.S. Environmental Protection Agency for making the
National Lakes Assessment data freely available, and Roger Bachmann for
sharing his working dataset. We acknowledge input provided by Lester
Yuan, Steve Carpenter, Tim Kratz, Patricia Soranno, and Emily Stanley on
early versions of this manuscript. We also thank Roger Bachmann and two
anonymous reviewers for their helpful comments. The information in this
document has been funded in part by the U.S. Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory and approved for publication.
This work was also supported by the Wisconsin Department of Natural
Resources and the National Science Foundation, North Temperate Lakes
Long-Term Ecological Research (Division of Environmental Biology,
DEB-0822700) and MacroSystems Biology program (Emerging Frontiers,
EF1065818).
NR 13
TC 2
Z9 2
U1 0
U2 14
PU AMER SOC LIMNOLOGY OCEANOGRAPHY
PI WACO
PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710-4446 USA
SN 0024-3590
EI 1939-5590
J9 LIMNOL OCEANOGR
JI Limnol. Oceanogr.
PD NOV
PY 2014
VL 59
IS 6
BP 2226
EP 2230
DI 10.4319/lo.2014.59.6.2226
PG 5
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA AU2QK
UT WOS:000345462700032
ER
PT J
AU Wu, QS
Lane, C
Liu, HX
AF Wu, Qiusheng
Lane, Charles
Liu, Hongxing
TI An Effective Method for Detecting Potential Woodland Vernal Pools Using
High-Resolution LiDAR Data and Aerial Imagery
SO REMOTE SENSING
LA English
DT Article
DE geographically isolated wetlands; seasonal wetlands; depression
analysis; Massachusetts
ID GEOGRAPHICALLY ISOLATED WETLANDS; SOUTHERN NEW-ENGLAND; WATER INDEX
NDWI; UNITED-STATES; CONSERVATION; LANDSCAPE; CONNECTIVITY; DEPRESSIONS;
DYNAMICS; MODELS
AB Effective conservation of woodland vernal pools-important components of regional amphibian diversity and ecosystem services-depends on locating and mapping these pools accurately. Current methods for identifying potential vernal pools are primarily based on visual interpretation and digitization of aerial photographs, with variable accuracy and low repeatability. In this paper, we present an effective and efficient method for detecting and mapping potential vernal pools using stochastic depression analysis with additional geospatial analysis. Our method was designed to take advantage of high-resolution light detection and ranging (LiDAR) data, which are becoming increasingly available, though not yet frequently employed in vernal pool studies. We successfully detected more than 2000 potential vernal pools in a similar to 150 km(2) study area in eastern Massachusetts. The accuracy assessment in our study indicated that the commission rates ranged from 2.5% to 6.0%, while the proxy omission rate was 8.2%, rates that are much lower than reported errors of previous vernal pool studies conducted in the northeastern United States. One significant advantage of our semi-automated approach for vernal pool identification is that it may reduce inconsistencies and alleviate repeatability concerns associated with manual photointerpretation methods. Another strength of our strategy is that, in addition to detecting the point-based vernal pool locations for the inventory, the boundaries of vernal pools can be extracted as polygon features to characterize their geometric properties, which are not available in the current statewide vernal pool databases in Massachusetts.
C1 [Wu, Qiusheng] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA.
[Lane, Charles] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Wu, Qiusheng; Liu, Hongxing] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
RP Wu, QS (reprint author), US EPA, Dynamac Corp, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Wu.Qiusheng@epa.gov; Lane.Charles@epa.gov; Hongxing.Liu@uc.edu
RI Wu, Qiusheng/C-7976-2016
OI Wu, Qiusheng/0000-0001-5437-4073
NR 59
TC 12
Z9 12
U1 5
U2 24
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-4292
J9 REMOTE SENS-BASEL
JI Remote Sens.
PD NOV
PY 2014
VL 6
IS 11
BP 11444
EP 11467
DI 10.3390/rs61111444
PG 24
WC Remote Sensing
SC Remote Sensing
GA AU3RG
UT WOS:000345530700053
ER
PT J
AU Consoer, DM
Hoffman, AD
Fitzsimmons, PN
Kosian, PA
Nichols, JW
AF Consoer, Daniel M.
Hoffman, Alex D.
Fitzsimmons, Patrick N.
Kosian, Patricia A.
Nichols, John W.
TI Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout
(Oncorhynchus mykiss)
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Perfluoroalkyl acid; Perfluorooctanoate; Rainbow trout; Renal
elimination; Tissue distribution; Membrane transporter
ID ORGANIC ANION TRANSPORTER; CHAIN PERFLUORINATED ACIDS; TANDEM
MASS-SPECTROMETRY; PERFLUOROALKYL ACIDS; RENAL EXCRETION;
P-GLYCOPROTEIN; DEVELOPMENTAL TOXICITY; EFFLUX TRANSPORTERS; TISSUE
DISTRIBUTION; WINTER FLOUNDER
AB Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctanoate (PFOA) by intra-arterial (i.a.) injection and sampled to obtain concentration time-course data for plasma, urine, and expired water. The data were then analyzed by compartmental modeling to estimate rates of renal and branchial clearance. Averaged across all animals, the renal clearance rate (1.35 mL/h/kg) was more than ten times greater than the branchial clearance rate (0.12 mL/h/kg). The average whole-body elimination half-life was 12.6 d, which is somewhat longer than values obtained in previous studies with smaller trout. The tissue distribution of PFOA was assessed by collecting tissues at the end of chambered exposures and in a separate tissue time-course experiment. From the time-course study it appeared that an internal steady-state was established within 24 h of i.a. injection. Consistent with previous studies, the rank order of PFOA concentration in tissues at steady state was: plasma > liver> kidney > muscle. In a second set of chambered experiments, fish were exposed to PFOA in water to determine the rate of branchial uptake. Branchial uptake rates were too low to assess directly by measuring PFOA concentrations in inspired and expired water. Uptake rate constants (mean 0.19 L/d/kg; 0.1% uptake efficiency) were therefore estimated by compartmental modeling using plasma concentration time-course data and model parameters derived from the elimination experiments. It is clear from this effort that elimination of PFOA by trout occurs primarily via the renal route. This finding is consistent with numerous studies of mammals and suggests that trout possess membrane transporters that facilitate the movement of PFOA from plasma to urine. Published by Elsevier B.V.
C1 [Consoer, Daniel M.; Hoffman, Alex D.; Fitzsimmons, Patrick N.; Kosian, Patricia A.; Nichols, John W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Nichols, JW (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM nichols.john@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does the mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 67
TC 5
Z9 6
U1 3
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD NOV
PY 2014
VL 156
BP 65
EP 73
DI 10.1016/j.aquatox.2014.07.022
PG 9
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA AT8NO
UT WOS:000345190000008
PM 25150511
ER
PT J
AU Maloney, SK
Fuller, A
Mitchell, D
Gordon, C
Overton, JM
AF Maloney, Shane K.
Fuller, Andrea
Mitchell, Duncan
Gordon, Christopher
Overton, J. Michael
TI Translating Animal Model Research: Does It Matter That Our Rodents Are
Cold?
SO PHYSIOLOGY
LA English
DT Article
ID DIET-INDUCED THERMOGENESIS; BROWN ADIPOSE-TISSUE; AMBIENT-TEMPERATURE;
LABORATORY MICE; NONSHIVERING THERMOGENESIS; HOUSING TEMPERATURE;
CALORIC RESTRICTION; BODY-TEMPERATURE; TRANSGENIC MICE; OLD RATS
AB Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
C1 [Maloney, Shane K.; Mitchell, Duncan] Univ Western Australia, Sch Anat Physiol & Human Biol, Crawley, WA, Australia.
[Maloney, Shane K.; Fuller, Andrea; Mitchell, Duncan] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, Parktown, South Africa.
[Gordon, Christopher] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
[Overton, J. Michael] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
RP Maloney, SK (reprint author), Univ Western Australia, Sch Anat Physiol & Human Biol, Stirling Highway, Crawley, WA, Australia.
OI Fuller, Andrea/0000-0001-6370-8151
NR 66
TC 19
Z9 20
U1 6
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1548-9213
EI 1548-9221
J9 PHYSIOLOGY
JI Physiology
PD NOV 1
PY 2014
VL 29
IS 6
BP 413
EP 420
DI 10.1152/physiol.00029.2014
PG 8
WC Physiology
SC Physiology
GA AT5QB
UT WOS:000344996000006
PM 25362635
ER
PT J
AU Burns, CJ
Wright, M
Pierson, JB
Bateson, TF
Burstyn, I
Goldstein, DA
Klaunig, JE
Luben, TJ
Mihlan, G
Ritter, L
Schnatter, AR
Symons, JM
Yi, KD
AF Burns, Carol J.
Wright, Michael
Pierson, Jennifer B.
Bateson, Thomas F.
Burstyn, Igor
Goldstein, Daniel A.
Klaunig, James E.
Luben, Thomas J.
Mihlan, Gary
Ritter, Leonard
Schnatter, A. Robert
Symons, J. Morel
Yi, Kun Don
TI Evaluating Uncertainty to Strengthen Epidemiologic Data for Use in Human
Health Risk Assessments
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID MATCHED CASE-CONTROL; MEASUREMENT ERROR; SENSITIVITY-ANALYSIS; EXPOSURE
ASSESSMENT; OCCUPATIONAL ASTHMA; BAYESIAN-ANALYSIS; LUNG-CANCER;
MISCLASSIFICATION; FRAMEWORK; BIAS
AB Background: There is a recognized ned to improve the application of epidemiologic data in human health risk assessment especially for understanding and characterizing risks from environmental and occupational exposures. Although there is uncertainty associated with the results of most epidemiologic studies, techniques exist to characterize uncertainty that can be applied to improve weight-of-evidence evaluations and risk characterization efforts.
Methods: This report derives from a Health and Environmental Sciences Institute (HESI) workshop held in Research Triangle Park, North Carolina, to discuss the utility of using epidemiologic data in risk assessments, including the use of advanced analytic methods to address sources of uncertainty. Epidemiologists, toxicologists, and risk assessors from academia, government, and industry convened to discuss uncertainty, exposure assessment, and application of analytic methods to address these challenges.
Synthesis: Several recommendations emerged to help improve the utility of epidemiologic data in risk assessment. For example, improved characterization of uncertainty is needed to allow risk assessors to quantitatively assess potential sources of bias. Data are needed to facilitate this quantitative analysis, and inter-disciplinary approaches will help ensure that sufficient information is collected for a thorough uncertainty evaluation. Advanced analytic methods and tools such as directed acyclic graphs (DAGs) and Bayesian statistical techniques can provide important insights and support interpretation of epidemiologic data.
Conclusions: The discussions and recommendations from this workshop demonstrate that there are practical steps that the scientific community can adopt to strengthen epidemiologic data for decision making.
C1 [Burns, Carol J.] Dow Chem Co USA, Midland, MI 48674 USA.
[Wright, Michael] US EPA, NCEA, Cincinnati, OH USA.
[Pierson, Jennifer B.] ILSI, HESI, Washington, DC USA.
[Bateson, Thomas F.] US EPA, NCEA, Washington, DC 20460 USA.
[Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19104 USA.
[Goldstein, Daniel A.] Monsanto Co, St Louis, MO USA.
[Klaunig, James E.] Indiana Univ, Sch Publ Hlth, Dept Environm Hlth, Bloomington, IN USA.
[Luben, Thomas J.] US EPA, NCEA, Res Triangle Pk, NC USA.
[Mihlan, Gary] Bayer CropSci, Res Triangle Pk, NC USA.
[Ritter, Leonard] Univ Guelph, Sch Environm Sci, Guelph, ON N1G 2W1, Canada.
[Schnatter, A. Robert] ExxonMobil Biomedical Sci Inc, Annandale, NJ USA.
[Symons, J. Morel] EI Pont Nemours & Co, Newark, DC USA.
[Yi, Kun Don] Syngenta Crop Protect LLC, Greensboro, NC USA.
RP Pierson, JB (reprint author), 1156 15th St NW,2nd Floor, Washington, DC 20005 USA.
EM jpierson@hesiglobal.org
FU ILSI-HESI
FX This work was conducted under the auspices of the ILSI-HESI Subcommittee
on Evaluating Causality in Epidemiologic Studies. HESI is a public,
nonprofit foundation whose mission is to engage scientists from
academia, government, and industry to identify and resolve global health
and environmental issues. HESI receives support primarily from its
industry sponsors. Participating organizations from the HESI
Epidemiology Subcommittee included Bayer CropScience, DLW Consulting
Services LLC, The Dow Chemical Company, Drexel University, E. I. du Pont
de Nemours and Company, ExxonMobil Biomedical Sciences Inc., Harvard
School of Public Health, Indiana University, Monsanto, Procter & Gamble
Co., Shell Oil Company, Syngenta Crop Protection LLC, University of
Aarhus, University of Guelph, University of Leicester, NCEA/U.S. EPA,
and Wake Forest University.
NR 64
TC 4
Z9 5
U1 1
U2 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1160
EP 1165
DI 10.1289/ehp.1308062
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500016
PM 25079138
ER
PT J
AU Vinikoor-Imler, LC
Owens, EO
Nichols, JL
Ross, M
Brown, JS
Sacks, JD
AF Vinikoor-Imler, Lisa C.
Owens, Elizabeth O.
Nichols, Jennifer L.
Ross, Mary
Brown, James S.
Sacks, Jason D.
TI Evaluating Potential Response-Modifying Factors for Associations between
Ozone and Health Outcomes: A Weight-of-Evidence Approach
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID CASE-CROSSOVER ANALYSIS; INDUCED AIRWAY HYPERRESPONSIVENESS; INDUCED
PULMONARY INFLAMMATION; EMERGENCY-DEPARTMENT VISITS; INDUCED LUNG
INFLAMMATION; NITRIC-OXIDE SYNTHASE; TOLL-LIKE RECEPTOR-4; ASTHMATIC
SUBJECTS; MEXICO-CITY; ANTIOXIDANT SUPPLEMENTATION
AB Background: Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O-3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O-3-related health effects.
Objectives: We sought to identify potential response-modifying factors to determine whether specific groups of the population or life stages are at increased or decreased risk of O-3-related health effects using a weight-of-evidence approach.
Methods: Epidemiologic, experimental, and exposure science studies of potential factors that may modify the relationship between O3 and health effects were identified in U. S. Environmental Protection Agency's 2013 Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Scientific evidence from studies that examined factors that may influence risk were integrated across disciplines to evaluate consistency, coherence, and biological plausibility of effects. The factors identified were then classified using a weight-of-evidence approach to conclude whether a specific factor modified the response of a population or life stage, resulting in an increased or decreased risk of O-3-related health effects.
Discussion: We found "adequate" evidence that populations with certain genotypes, preexisting asthma, or reduced intake of certain nutrients, as well as different life stages or outdoor workers, are at increased risk of O-3-related health effects. In addition, we identified other factors (i.e., sex, socioeconomic status, and obesity) for which there was "suggestive" evidence that they may increase the risk of O-3-related health effects.
Conclusions: Using a weight-of-evidence approach, we identified a diverse group of factors that should be considered when characterizing the overall risk of health effects associated with exposures to ambient O-3.
C1 [Vinikoor-Imler, Lisa C.; Owens, Elizabeth O.; Ross, Mary; Brown, James S.; Sacks, Jason D.] US EPA, NCEA, Res Triangle Pk, NC 27711 USA.
[Nichols, Jennifer L.] US EPA, NCEA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Vinikoor-Imler, LC (reprint author), 109 TW Alexander Dr,MD B243-01, Res Triangle Pk, NC 27711 USA.
EM vinikoor-imler.lisa@epa.gov
FU National Center of Environmental Assessment, Office of Research and
Development, U.S. EPA
FX This project was supported in part by the appointment of J.L.N. to the
Research Participation Program at the National Center of Environmental
Assessment, Office of Research and Development, U.S. EPA, administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the U.S. Department of Energy
NR 141
TC 8
Z9 8
U1 2
U2 22
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1166
EP 1176
DI 10.1289/ehp.1307541
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500017
PM 24927060
ER
PT J
AU Dionisio, KL
Baxter, LK
Chang, HH
AF Dionisio, Kathie L.
Baxter, Lisa K.
Chang, Howard H.
TI An Empirical Assessment of Exposure Measurement Error and Effect
Attenuation in Bipollutant Epidemiologic Models
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID EMERGENCY-DEPARTMENT VISITS; AMBIENT AIR-POLLUTION; TIME-SERIES;
PARTICULATE MATTER; NITROGEN-DIOXIDE; ATLANTA; HEALTH; POLLUTANTS;
OZONE; QUALITY
AB BACKGROUND: Using multipollutant models to understand combined health effects of exposure to multiple pollutants is becoming more common. However, complex relationships between pollutants and differing degrees of exposure error across pollutants can make health effect estimates from multipollutant models difficult to interpret.
OBJECTIVES: We aimed to quantify relationships between multiple pollutants and their associated exposure errors across metrics of exposure and to use empirical values to evaluate potential attenuation of coefficients in epidemiologic models.
METHODS: We used three daily exposure metrics (central-site measurements, air quality model estimates, and population exposure model estimates) for 193 ZIP codes in the Atlanta, Georgia, metropolitan area from 1999 through 2002 for PM2.5 and its components (EC and SO4), as well as O-3, CO, and NOx, to construct three types of exposure error: delta(spatial) (comparing air quality model estimates to central-site measurements), delta(population) (comparing population exposure model estimates to air quality model estimates), and delta(total) (comparing population exposure model estimates to central-site measurements). We compared exposure metrics and exposure errors within and across pollutants and derived attenuation factors (ratio of observed to true coefficient for pollutant of interest) for single- and bipollutant model coefficients.
RESULTS: Pollutant concentrations and their exposure errors were moderately to highly correlated (typically, > 0.5), especially for CO, NOx, and EC (i.e., "local" pollutants); correlations differed across exposure metrics and types of exposure error. Spatial variability was evident, with variance of exposure error for local pollutants ranging from 0.25 to 0.83 for delta(spatial) and delta(total). The attenuation of model coefficients in single-and bipollutant epidemiologic models relative to the true value differed across types of exposure error, pollutants, and space.
CONCLUSIONS: Under a classical exposure-error framework, attenuation may be substantial for local pollutants as a result of delta(spatial) and delta(total) with true coefficients reduced by a factor typically < 0.6 (results varied for delta(population) and regional pollutants).
C1 [Dionisio, Kathie L.; Baxter, Lisa K.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
[Chang, Howard H.] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
RP Dionisio, KL (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA.
EM dionisio.kathie@epa.gov
FU U.S. EPA, through its Office of Research and Development, National
Exposure Research Laboratory [CR-83407301-1]; U.S. EPA Clean Air
Research Center grant; Georgia Institute of Technology [R834799];
National Institutes of Health [1R21ES022795-01A1]
FX The U.S. EPA, through its Office of Research and Development, National
Exposure Research Laboratory, funded and collaborated in the research
described here under cooperative agreement CR-83407301-1 to Emory
University, and by a U.S. EPA Clean Air Research Center grant to Emory
University and the Georgia Institute of Technology (R834799). This work
was also funded by grant 1R21ES022795-01A1 from the National Institutes
of Health.
NR 31
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Z9 6
U1 0
U2 15
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1216
EP 1224
DI 10.1289/ehp.1307772
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500023
PM 25003573
ER
PT J
AU Divi, RL
Lindeman, TLE
Shockley, ME
Keshava, C
Weston, A
Poirier, MC
AF Divi, Rao L.
Lindeman, Tracey L. Einem
Shockley, Marie E.
Keshava, Channa
Weston, Ainsley
Poirier, Miriam C.
TI Correlation between CYP1A1 transcript, protein level, enzyme activity
and DNA adduct formation in normal human mammary epithelial cell strains
exposed to benzo[a]pyrene
SO MUTAGENESIS
LA English
DT Article
ID FED COAL-TAR; BREAST-CANCER; DIOL-EPOXIDE; P450 REDUCTASE;
DT-DIAPHORASE; EROD ACTIVITY; RISK; MICE; CYTOCHROME-P450; BIOMARKERS
AB The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N (2) -deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to understand the contribution of different metabolic enzymes to BPdG formation, is typically presented as fold-change observed upon BP exposure, leaving the actual number of RNA transcripts unknown. Here, we have quantified RNA copies/ng cDNA (RNA cpn) for CYP1A1 and CYP1B1, as well as NAD(P)H:quinone oxidoreductase 1 (NQO1), which may reduce formation of BPdG adducts, using primary normal human mammary epithelial cell (NHMEC) strains, and the MCF-7 breast cancer cell line. In unexposed NHMECs, basal RNA cpn values were 58-836 for CYP1A1, 336-5587 for CYP1B1 and 5943-40112 for NQO1. In cells exposed to 4.0 A mu M BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. There were 3.5 (mean, range 0.2-15.8) BPdG adducts/10(8) nucleotides in the NHMECs (n = 16), and 790 in the MCF-7s. In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Western blots of four NHMEC strains, chosen for different levels of BPdG adducts, showed a linear correlation between BPdG and CYP1A1, but not CYP1B1 or NQO1. Ethoxyresorufin-O-deethylase (EROD) activity, which measures CYP1A1 and CYP1B1 together, correlated with BPdG, but NQO1 activity did not. Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. The higher level of BPdG in MCF-7 cells, compared to NHMECs, may have been due to a much increased induction of CYP1A1 and EROD. Overall, BPdG correlation was observed with CYP1A1 protein and CYP1A1/1B1 enzyme activity, but not with CYP1B1 or NQO1 protein, or NQO1 enzyme activity.
C1 [Divi, Rao L.; Lindeman, Tracey L. Einem; Shockley, Marie E.; Poirier, Miriam C.] NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bethesda, MD 20817 USA.
[Keshava, Channa] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Weston, Ainsley] Ctr Dis Control & Prevent, Div Resp Dis Studies, NIOSH, Morgantown, WV 26505 USA.
RP Poirier, MC (reprint author), NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bethesda, MD 20817 USA.
EM poirierm@exchange.nih.gov
FU Intramural NIH HHS
NR 39
TC 4
Z9 4
U1 3
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD NOV
PY 2014
VL 29
IS 6
BP 409
EP 417
DI 10.1093/mutage/geu049
PG 9
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA AT0KI
UT WOS:000344624700003
PM 25245543
ER
PT J
AU Thybaud, V
Van Benthem, J
Delrue, N
Douglas, GR
Lorge, E
Lovell, DP
Moore, MM
Schoeny, R
Singer, T
AF Thybaud, Veronique
Van Benthem, Jan
Delrue, Nathalie
Douglas, George R.
Lorge, Elisabeth
Lovell, David P.
Moore, Martha M.
Schoeny, Rita
Singer, Tim
TI Revision of OECD guidelines for genotoxicity: current status and next
steps
SO MUTAGENESIS
LA English
DT Meeting Abstract
C1 [Thybaud, Veronique] Sanofi, Vitry Sur Seine, France.
[Van Benthem, Jan] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
[Delrue, Nathalie] OECD, Paris, France.
[Douglas, George R.; Singer, Tim] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Lorge, Elisabeth] Servier Grp, Orleans, France.
[Lovell, David P.] Univ London, London WC1E 7HU, England.
[Moore, Martha M.] ENVIRON Int Corp, Little Rock, AR USA.
[Schoeny, Rita] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD NOV
PY 2014
VL 29
IS 6
BP 517
EP 517
PG 1
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA AT0KI
UT WOS:000344624700075
ER
PT J
AU Smucker, NJ
Detenbeck, NE
AF Smucker, Nathan J.
Detenbeck, Naomi E.
TI Meta-Analysis of Lost Ecosystem Attributes in Urban Streams and the
Effectiveness of Out-of-Channel Management Practices
SO RESTORATION ECOLOGY
LA English
DT Article
DE algae; biodiversity; ecosystem function; fish; macroinvertebrates;
restoration; stormwater; watershed condition
ID RIVER RESTORATION SUCCESS; LAND-USE; MACROINVERTEBRATE COMMUNITIES;
URBANIZATION; LANDSCAPE; RESPONSES; CATCHMENT; FISH; BIODIVERSITY;
AUSTRALIA
AB Urban development is a leading cause of stream impairment that reduces biodiversity and negatively affects ecosystem processes and habitat. Out-of-stream restoration practices, such as stormwater ponds, created wetlands, and restored riparian vegetation, are increasingly implemented as management strategies to mitigate impacts. However, uncertainty exists regarding how effectively they improve downstream ecosystems because monitoring is uncommon and results are typically reported on a case-by-case basis. We conducted a meta-analysis of literature and used response ratios to quantify how downstream ecosystems change in response to watershed development and to out-of-stream restoration. Biodiversity in unrestored urban streams was 47% less than that in reference streams, and ecological communities, habitat, and rates of nutrient cycling were negatively affected as well. Mean measures of ecosystem attributes in restored streams were significantly greater than, and 156% of, those in unrestored urban streams. Measures of biodiversity in restored streams were 132% of those in unrestored urban streams, and indices of biotic condition, community structure, and nutrient cycling significantly improved. However, ecosystem attributes and biodiversity at restored sites were significantly less than, and only 60% and 45% of, those in reference streams, respectively. Out-of-stream management practices improved ecological conditions in urban streams but still failed to restore reference stream conditions. Despite statistically significant improvements, assessing restoration success remains difficult due to few comparisons to reference sites or to clearly defined targets. These findings can inform future monitoring, management, and development strategies and highlight the need for preventative actions in a watershed context.
C1 [Smucker, Nathan J.; Detenbeck, Naomi E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Smucker, NJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM smucker.nathan@epa.gov
NR 51
TC 16
Z9 16
U1 4
U2 93
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-2971
EI 1526-100X
J9 RESTOR ECOL
JI Restor. Ecol.
PD NOV
PY 2014
VL 22
IS 6
BP 741
EP 748
DI 10.1111/rec.12134
PG 8
WC Ecology
SC Environmental Sciences & Ecology
GA AS8DL
UT WOS:000344480300006
ER
PT J
AU Ranson, M
Kousky, C
Ruth, M
Jantarasami, L
Crimmins, A
Tarquinio, L
AF Ranson, Matthew
Kousky, Carolyn
Ruth, Matthias
Jantarasami, Lesley
Crimmins, Allison
Tarquinio, Lisa
TI Tropical and extratropical cyclone damages under climate change
SO CLIMATIC CHANGE
LA English
DT Article
ID FUTURE CLIMATE; STORM LOSSES; SIMULATIONS; IMPACTS; COSTS; FUND; GCM; US
AB This paper provides the first quantitative synthesis of the rapidly growing literature on future tropical and extratropical cyclone damages under climate change. We estimate a probability distribution for the predicted impact of changes in global surface air temperatures on future storm damages, using an ensemble of 478 estimates of the temperature-damage relationship from nineteen studies. Our analysis produces three main empirical results. First, we find strong but not conclusive support for the hypothesis that climate change will cause damages from tropical cyclones and wind storms to increase, with most models predicting higher future storm damages due to climate change. Second, there is substantial variation in projected changes in losses across regions. Potential changes in damages are greatest in the North Atlantic basin, where the multi-model average predicts that a 2.5 A degrees C increase in global surface air temperature would cause hurricane damages to increase by 63 %. The ensemble predictions for Western North Pacific tropical cyclones and European wind storms (extratropical cyclones) are +28 % and +23 %, respectively. Finally, our analysis shows that existing models of storm damages under climate change generate a wide range of predictions, ranging from moderate decreases to very large increases in losses.
C1 [Ranson, Matthew; Tarquinio, Lisa] ABT Associates Inc, Cambridge, MA 02138 USA.
[Kousky, Carolyn] Resources Future Inc, Washington, DC 20036 USA.
[Ruth, Matthias] Northeastern Univ, Boston, MA 02115 USA.
[Jantarasami, Lesley; Crimmins, Allison] US EPA, Climate Change Div, Washington, DC 20460 USA.
RP Ranson, M (reprint author), ABT Associates Inc, 55 Wheeler St, Cambridge, MA 02138 USA.
EM matthew_ranson@abtassoc.com
FU U.S. Environmental Protection Agency's Climate Change Division
[EP-BPA-12-H-0024]
FX The authors wish to acknowledge the financial support of the U.S.
Environmental Protection Agency's Climate Change Division (Contract
EP-BPA-12-H-0024). The views expressed in this document are solely those
of the authors, and do not necessarily reflect those of U.S. EPA or Abt
Associates. The authors thank Eberhard Faust, James Palardy, Marcus
Sarofim, and seminar participants at Abt Associates for helpful
suggestions. Any errors are our own responsibility.
NR 35
TC 3
Z9 3
U1 1
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-0009
EI 1573-1480
J9 CLIMATIC CHANGE
JI Clim. Change
PD NOV
PY 2014
VL 127
IS 2
BP 227
EP 241
DI 10.1007/s10584-014-1255-4
PG 15
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AS6QG
UT WOS:000344387000006
ER
PT J
AU Ankley, GT
Jensen, KM
AF Ankley, Gerald T.
Jensen, Kathleen M.
TI A NOVEL FRAMEWORK FOR INTERPRETATION OF DATA FROM THE FISH SHORT-TERM
REPRODUCTION ASSAY (FSTRA) FOR THE DETECTION OF ENDOCRINE-DISRUPTING
CHEMICALS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Endocrine-disrupting chemicals; Fish; Reproduction; Screening;
Regulation
ID MINNOW PIMEPHALES-PROMELAS; FATHEAD MINNOW; ANDROGEN
17-ALPHA-METHYLTESTOSTERONE; ANTIANDROGEN FLUTAMIDE; SYNTHETIC
PROGESTINS; MECHANISTIC BASIS; RECEPTOR AGONIST; LIFE-CYCLE; INHIBITOR;
VITELLOGENIN
AB The fish short-term reproduction assay (FSTRA) is a key component of the US Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP), which uses a weight-of-evidence analysis based on data from several assays to identify the potential for chemicals to act as agonists or antagonists of the estrogen or androgen receptors (ER and AR), or inhibitors of steroidogenic enzymes. The FSTRA considers a variety of mechanistic and apical responses in 21-d exposures with the fathead minnow (Pimephales promelas), including plasma steroid and vitellogenin (VTG; egg yolk protein) concentrations, secondary sex characteristics, gonad size and histopathology, and egg production. Although the FSTRA initially was described several years ago, recent data generation associated with implementation of the EDSP highlighted the need for more formal guidance regarding evaluation of information from the assay. The authors describe a framework for interpretation of FSTRA data relative to perturbation of endocrine pathways of concern to the EDSP. The framework considers end points individually and as suites of physiologically related responses relative to pathway identification. Sometimes changes in single end points can be highly diagnostic (e.g., induction of VTG in males by ER agonists, production of male secondary sex characteristics in females by AR agonists); in other instances, however, multiple, related end points are needed to reliably assess pathway perturbation (e.g., AR antagonism, steroid synthesis inhibition). In addition to describing an interpretive framework, the authors demonstrate its practical utility using publicly available FSTRA data for a wide range of known and hypothesized endocrine-disrupting chemicals. Environ Toxicol Chem 2014;33:2529-2540. Published 2014 Wiley Periodicals Inc., on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
C1 [Ankley, Gerald T.; Jensen, Kathleen M.] US EPA, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA.
RP Ankley, GT (reprint author), US EPA, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA.
EM ankley.gerald@epa.gov
NR 72
TC 10
Z9 10
U1 4
U2 37
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD NOV
PY 2014
VL 33
IS 11
BP 2529
EP 2540
DI 10.1002/etc.2708
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AS3LB
UT WOS:000344178100021
PM 25098918
ER
PT J
AU Sutula, M
Green, L
Cicchetti, G
Detenbeck, N
Fong, P
AF Sutula, Martha
Green, Lauri
Cicchetti, Giancarlo
Detenbeck, Naomi
Fong, Peggy
TI Thresholds of Adverse Effects of Macroalgal Abundance and Sediment
Organic Matter on Benthic Habitat Quality in Estuarine Intertidal Flats
SO ESTUARIES AND COASTS
LA English
DT Article
DE Macroalgae; Eutrophication; Thresholds; Sediment profile imaging;
Benthic habitat quality; Percent organic carbon; Percent nitrogen
ID LONG-TERM CHANGES; ENTEROMORPHA-INTESTINALIS; NUTRIENT ENRICHMENT;
PROFILE CAMERA; TROPHIC STATUS; IN-SITU; MATS; GROWTH; BAY; CONSEQUENCES
AB Confidence in the use of macroalgae as an indicator of estuarine eutrophication is limited by the lack of quantitative data on the thresholds of its adverse effects on benthic habitat quality. In the present study, we utilized sediment profile imagery (SPI) to identify thresholds of adverse effects of macroalgal biomass, sediment organic carbon (% OC) and sediment nitrogen (% N) concentrations on the apparent Redox Potential Discontinuity (aRPD), the depth that marks the boundary between oxic near-surface sediment and the underlying suboxic or anoxic sediment. At 16 sites in eight California estuaries, SPI, macroalgal biomass, sediment percent fines, % OC, and % N were analyzed at 20 locations along an intertidal transect. Classification and Regression Tree (CART) analysis was used to identify step thresholds associated with a transition from "reference" or natural background levels of macroalgae, defined as that range in which no effect on aRPD was detected. Ranges of 3-15 g dw macroalgae m(-2), 0.4-0.7 % OC and 0.05-0.07 % N were identified as transition zones from reference conditions across these estuaries. Piecewise regression analysis was used to identify exhaustion thresholds, defined as a region along the stress-response curve where severe adverse effects occur; levels of 175 g dw macroalgae m(-2), 1.1 % OC and 0.1 % N were identified as thresholds associated with a shallowing of aRPD to near zero depths. As an indicator of ecosystem condition, shallow aRPD has been related to reduced volume and quality for benthic infauna and alteration in community structure. These effects have been linked to reduced availability of forage for fish, birds and other invertebrates, as well as to undesirable changes in biogeochemical cycling.
C1 [Sutula, Martha] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA.
[Green, Lauri; Fong, Peggy] Univ Calif Los Angeles, Dept Evolutionary Biol & Ecol, Los Angeles, CA 90095 USA.
[Cicchetti, Giancarlo; Detenbeck, Naomi] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Sutula, M (reprint author), Southern Calif Coastal Water Res Project, 3535 Harbor Blvd, Costa Mesa, CA 92626 USA.
EM marthas@sccwrp.org
RI Fong, Patrick S.W./O-7315-2014
OI Fong, Patrick S.W./0000-0002-2017-5698
FU California State Water Resources Control Board [07-110-250-1]
FX Funding for this study was provided through a contract with the
California State Water Resources Control Board (07-110-250-1). This
study would not have been possible without the hard work and dedication
of students and staff from UCLA and SCCWRP, in particular, Courtney
Neumann, who performed all of the digital imaging analysis of the SPI
photographs, and Caitlin Fong, Sarah Bittick and Greg Lyon, who led
field work. The authors also wish to express their gratitude to Becky
Schaffner for assistance with map preparation.
NR 62
TC 7
Z9 7
U1 2
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD NOV
PY 2014
VL 37
IS 6
BP 1532
EP 1548
DI 10.1007/s12237-014-9796-3
PG 17
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AR6WY
UT WOS:000343722700016
ER
PT J
AU Moya, J
Phillips, L
AF Moya, Jacqueline
Phillips, Linda
TI A review of soil and dust ingestion studies for children
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Review
ID MOUTH FREQUENCY DATA; SUPERFUND SITE; YOUNG-CHILDREN; TRACER ELEMENTS;
PREGNANT-WOMEN; MASS-BALANCE; LEAD; PICA; EXPOSURE; METAANALYSIS
AB Soil and dust ingestion by children may be important pathways of exposure to environmental contaminants. Contaminated soil and dust may end up on children's hands and objects, because they play close to the ground. These contaminants can be ingested by children, because they have a tendency to place objects, including their fingers, in their mouths. Assessing exposure through this pathway requires information about the amount of soil and dust ingested by children. Estimates of soil and dust ingestion and information on the prevalence of the behavior have been published in the literature, but research in this area is generally limited. Three methodologies have been used to quantify soil and dust ingestion rates. In this paper, these are referred to as the tracer element method, the biokinetic model comparison method, and the activity pattern method. This paper discusses the information available on the prevalence of soil and dust ingestion behavior, summarizes the three methodologies for quantifying soil and dust ingestion, and discusses their limitations. Soil ingestion data derived from studies that use these methodologies are also summarized. Although they are based on different estimation approaches, the central tendency estimates of soil and dust ingestion derived from the three methodologies are generally comparable.
C1 [Moya, Jacqueline; Phillips, Linda] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Phillips, L (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Mailcode 8623P,1200 Penn Ave NW, Washington, DC 20460 USA.
EM phillips.linda@epa.gov
NR 64
TC 6
Z9 6
U1 2
U2 24
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 545
EP 554
DI 10.1038/jes.2014.17
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800001
PM 24691008
ER
PT J
AU Breen, MS
Schultz, BD
Sohn, MD
Long, T
Langstaff, J
Williams, R
Isaacs, K
Meng, QY
Stallings, C
Smith, L
AF Breen, Michael S.
Schultz, Bradley D.
Sohn, Michael D.
Long, Thomas
Langstaff, John
Williams, Ronald
Isaacs, Kristin
Meng, Qing Yu
Stallings, Casson
Smith, Luther
TI A review of air exchange rate models for air pollution exposure
assessments
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Review
DE Air exchange rate models; air pollution; exposure assessment; leakage;
natural ventilation; mechanical ventilation
ID PARTICULATE MATTER; UNITED-STATES; INFILTRATION; OUTDOOR; WIND;
TEMPERATURE; BUILDINGS; INDOOR; VENTILATION; POLLUTANTS
AB A critical aspect of air pollution exposure assessments is estimation of the air exchange rate (AER) for various buildings where people spend their time. The AER, which is the rate of exchange of indoor air with outdoor air, is an important determinant for entry of outdoor air pollutants and for removal of indoor-emitted air pollutants. This paper presents an overview and critical analysis of the scientific literature on empirical and physically based AER models for residential and commercial buildings; the models highlighted here are feasible for exposure assessments as extensive inputs are not required. Models are included for the three types of airflows that can occur across building envelopes: leakage, natural ventilation, and mechanical ventilation. Guidance is provided to select the preferable AER model based on available data, desired temporal resolution, types of airflows, and types of buildings included in the exposure assessment. For exposure assessments with some limited building leakage or AER measurements, strategies are described to reduce AER model uncertainty. This review will facilitate the selection of AER models in support of air pollution exposure assessments.
C1 [Breen, Michael S.; Schultz, Bradley D.; Williams, Ronald; Isaacs, Kristin] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Sohn, Michael D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Dept Energy Anal & Environm Impacts, Berkeley, CA 94720 USA.
[Long, Thomas] US EPA, Natl Ctr Environm Assessments, Res Triangle Pk, NC 27711 USA.
[Langstaff, John] US EPA, Off Air Qual & Planning Stand, Res Triangle Pk, NC 27711 USA.
[Meng, Qing Yu] UMDNJ Sch Publ Hlth, Dept Environm & Occupat Hlth, Piscataway, NJ USA.
[Stallings, Casson; Smith, Luther] Alion Sci & Technol Inc, Res Triangle Pk, NC USA.
RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Exposure Modeling Res Branch,Off Res & Dev, 109 TW Alexander Dr,Mail E205-02, Res Triangle Pk, NC 27711 USA.
EM breen.michael@epa.gov
FU U.S. Department of Energy [DE-AC02-05CH11231]
FX We thank Jennifer Richmond-Bryant and Vito Ilacqua for review comments
and helpful suggestions. Although the manuscript was reviewed by the US
Environmental Protection Agency and approved for publication, it may not
necessarily reflect official Agency policy. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use. Michael Sohn performed this work under Contract No.
DE-AC02-05CH11231 with the U.S. Department of Energy.
NR 61
TC 9
Z9 9
U1 3
U2 33
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 555
EP 563
DI 10.1038/jes.2013.30
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800002
PM 23715084
ER
PT J
AU Xue, J
Liu, SV
Zartarian, VG
Geller, AM
Schultz, BD
AF Xue, Jianping
Liu, Shi V.
Zartarian, Valerie G.
Geller, Andrew M.
Schultz, Bradley D.
TI Analysis of NHANES measured blood PCBs in the general US population and
application of SHEDS model to identify key exposure factors
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE PCBs; NHANES; SHEDS; dietary exposure; exposure modeling; biomonitoring
ID POLYCHLORINATED BIPHENYL LEVELS; PERSISTENT ORGANIC POLLUTANTS;
GREAT-LAKES; SERUM CONCENTRATIONS; NONDIABETIC ADULTS; FISH CONSUMPTION;
TEMPORAL TRENDS; CHILDREN; DISEASE; MICHIGAN
AB Studies have shown that the US population continues to be exposed to polychlorinated biphenyls (PCBs), despite their ban more than three decades ago, but the reasons are not fully understood. The objectives of this paper are to characterize patterns of PCBs in blood by age, gender, and ethnicity, and identify major exposure factors. EPA's Stochastic Human Exposure and Dose Simulation (SHEDS)-dietary exposure model was applied, combining fish tissue PCB levels from a NYC Asian Market survey with National Health and Nutrition Examination Survey (NHANES) dietary consumption data, and then linked with blood biomarkers for the same NHANES study subjects. Results reveal that the mean concentration of total PCBs in blood was higher with increasing age; however, for the same age, gender, and ethnicity, the blood PCB concentrations measured in the later NHANES survey were significantly lower than those in the earlier one. The decrease within an age group between the two survey periods lessened with increasing age. Blood PCBs among different ethnicities ranked differently between the older and the younger age groups within each survey. Non-Hispanic Blacks had significantly higher blood PCBs for the >30 year age group. For the 12 to <= 30 year age group, the "Asian, Pacific Islander, Native American or multiracial" group had the highest values, with patterns fairly consistent with fish consumption and modeled PCB exposure patterns. We conclude that for younger people, patterns correspond to reduced environmental contamination over time, and are strongly associated with fish consumption and dietary exposures. Higher PCB concentrations in blood of the older population may partially reflect past exposures to higher environmental PCB concentrations, particularly before the ban.
C1 [Xue, Jianping; Liu, Shi V.; Zartarian, Valerie G.; Geller, Andrew M.; Schultz, Bradley D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Xue, J (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, NC, 109 TW Alexander Dr,MD E205-02, Res Triangle Pk, NC 27711 USA.
EM Xue.jianping@epa.gov; Liu.Shi@epa.gov
NR 48
TC 7
Z9 7
U1 0
U2 20
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 615
EP 621
DI 10.1038/jes.2013.91
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800010
PM 24424407
ER
PT J
AU Varughese, EA
Bennett-Stamper, CL
Wymer, LJ
Yadav, JS
AF Varughese, Eunice A.
Bennett-Stamper, Christina L.
Wymer, Larry J.
Yadav, Jagjit S.
TI A new in vitro model using small intestinal epithelial cells to enhance
infection of Cryptosporidium parvum
SO JOURNAL OF MICROBIOLOGICAL METHODS
LA English
DT Article
DE Cryptosporidium parvum; FHs 74 Int; In vitro; Excystation; Infection;
Parasite
ID IMMUNOFLUORESCENCE ASSAY; PUBLIC-HEALTH; OOCYSTS; CULTURE; VIABILITY;
EXCYSTATION; BIOLOGY; LINES; INACTIVATION; CULTIVATION
AB To better understand and study the infection of the protozoan parasite Cryptosporidium parvum, a more sensitive in vitro assay is required. In vivo, this parasite infects the epithelial cells of the microvilli layer in the small intestine. While cell infection models using colon, kidney, and stomach cells have been studied to understand the infectivity potential of the oocysts, an ideal in vitro model would be readily-available, human-derived, and originating from the small intestine. In this study, we developed a reproducible, quantitative infection model using a non-carcinoma, human small intestinal epithelial cell type, named FHs 74 Int. Our results show that FHs 74 Int cells are productively infected by viable oocysts, and exhibit higher levels of infection susceptibility compared to other cell types. Moreover, infection rate of the sporozoites on the monolayer was found to be comparable or better than other cell types. We furthermore demonstrate that infection can be improved by 65% when pre-treated oocysts are directly inoculated on cells, compared to inoculation of excysted sporozoites on cells. Identification of a better infection model, which captures the preferred site of infection in humans, will facilitate studies on the host pathogenesis mechanisms of this important parasitic human pathogen. Published by Elsevier B.V.
C1 [Varughese, Eunice A.; Yadav, Jagjit S.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Environm Genet & Mol Toxicol, Cincinnati, OH 45267 USA.
[Varughese, Eunice A.; Wymer, Larry J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Bennett-Stamper, Christina L.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varughese, EA (reprint author), US EPA, AWBERC, 26 W Martin Luther King,MS 587, Cincinnati, OH 45268 USA.
EM varughese.eunice@epa.gov; jagjit.yadav@uc.edu
FU U.S. Environmental Protection Agency, through its Office of Research and
Development
FX The research was supported by the U.S. Environmental Protection Agency,
through its Office of Research and Development. It has been subjected to
the Agency's administrative review and approved for publication.
NR 48
TC 6
Z9 6
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-7012
EI 1872-8359
J9 J MICROBIOL METH
JI J. Microbiol. Methods
PD NOV
PY 2014
VL 106
BP 47
EP 54
DI 10.1016/j.mimet.2014.07.017
PG 8
WC Biochemical Research Methods; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA AR1PX
UT WOS:000343358200008
PM 25072838
ER
PT J
AU Bateson, TF
AF Bateson, Thomas F.
TI Analysing health data from rare occupational cohorts
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Editorial Material
ID SHORT-TERM; MORTALITY EXPERIENCE; WORKERS; EXPOSURE
C1 US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Bateson, TF (reprint author), US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
EM bateson.thomas@epa.gov
NR 12
TC 1
Z9 1
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
EI 1470-7926
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD NOV
PY 2014
VL 71
IS 11
BP 742
EP 743
DI 10.1136/oemed-2014-102298
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AR6CX
UT WOS:000343671800002
PM 25165396
ER
PT J
AU Boethling, R
AF Boethling, Robert
TI Comparison of ready biodegradation estimation methods for fragrance
materials
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Fragrance; Ready biodegradation; Estimation; Biowin (c); QSAR; VEGA (c)
ID AEROBIC BIODEGRADATION; MICROBIAL-DEGRADATION; CHEMICAL STRUCTURE;
ALIPHATIC ACIDS; MODELS; PREDICTION; POLLUTANTS; HAZARD
AB Biodegradability is fundamental to the assessment of environmental exposure and risk from organic chemicals. Predictive models can be used to pursue both regulatory and chemical design (green chemistry) objectives, which are most effectively met when models are easy to use and available free of charge. The objective of this work was to evaluate no-cost estimation programs with respect to prediction of ready biodegradability. Fragrance materials, which are structurally diverse and have significant exposure potential, were used for this purpose. Using a database of 222 fragrance compounds with measured ready biodegradability, 10 models were compared on the basis of overall accuracy, sensitivity, specificity, and Matthews correlation coefficient (MCC), a measure of quality for binary classification. The 10 models were VEGA(C) Non-Interactive Client, START (Toxtree(C)), Biowin(C)1-6, and two models based on inductive machine learning. Applicability domain (AD) was also considered. Overall accuracy was ca. 70% and varied little over all models, but sensitivity, specificity and MCC showed wider variation. Based on MCC, the best models for fragrance compounds were Biowin6, VEGA and Biowin3. VEGA performance was slightly better for the <50% of the compounds it identified as having "high reliability" predictions (AD index >0.8). However, removing compounds with one and only one quaternary carbon yielded similar improvement in predictivity for VEGA, START, and Biowin3/6, with a smaller penalty in reduced coverage. Of the nine compounds for which the eight models (VEGA, START, Biowin1-6) all disagreed with the measured value, measured analog data were available for seven, and all supported the predicted value. VEGA, Biowin3 and Biowin6 are judged suitable for ready biodegradability screening of fragrance compounds. Published by Elsevier B.V.
C1 [Boethling, Robert] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Boethling, R (reprint author), US EPA, 1200 Penn Ave,NW, Washington, DC 20460 USA.
EM Robert_Boethling@abtassoc.com
NR 36
TC 6
Z9 6
U1 1
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 1
PY 2014
VL 497
BP 60
EP 67
DI 10.1016/j.scitotenv.2014.07.090
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GM
UT WOS:000343613100007
PM 25119791
ER
PT J
AU Heaney, CD
Exum, NG
Dufour, AP
Brenner, KP
Haugland, RA
Chern, E
Schwab, KJ
Love, DC
Serre, ML
Noble, R
Wade, TJ
AF Heaney, Christopher D.
Exum, Natalie G.
Dufour, Alfred P.
Brenner, Kristen P.
Haugland, Richard A.
Chern, Eunice
Schwab, Kellogg J.
Love, David C.
Serre, Marc L.
Noble, Rachel
Wade, Timothy J.
TI Water quality, weather and environmental factors associated with fecal
indicator organism density in beach sand at two recreational marine
beaches
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Beach sand; Water quality; Rainfall; Fecal pollution; Enterococci; qPCR
ID NONPOINT-SOURCE POLLUTION; POLYMERASE-CHAIN-REACTION; REAL-TIME PCR;
ESCHERICHIA-COLI; LAKE-MICHIGAN; HUNTINGTON-BEACH; SUBTROPICAL
ENVIRONMENT; TEMPORAL VARIATION; NEARSHORE WATER; COASTAL WATERS
AB Recent studies showing an association between fecal indicator organisms (FIOs) in sand and gastrointestinal (GI) illness among beachgoers with sand contact have important public health implications because of the large numbers of people who recreate at beaches and engage in sand contact activities. Yet, factors that influence fecal pollution in beach sand remain unclear. During the 2007 National Epidemiological and Environmental Assessment of Recreational (NEEAR) Water Study, sand samples were collected at three locations (60 m apart) on weekend days (Sat, Sun) and holidays between June and September at two marine beaches - Fairhope Beach, AL and Goddard Beach, RI - with nearby publicly-owned treatment works (POTWs) outfalls. F+ coliphage, enterococci, Bacteroidales, fecal Bacteroides spp., and Clostridium spp. were measured in sand using culture and qPCR-based calibrator-cell equivalent methods. Water samples were also collected on the same days, times and transects as the 144 sand samples and were assayed using the same FIO measurements. Weather and environmental data were collected at the time of sample collection. Mean FIO concentrations in sand varied over time, but not space. Enterococci CPU and CCE densities in sand were not correlated, although other FIOs in sand were. The strongest correlation between FIO density in sand and water was fecal Bacteroides CCE, followed by enterococci CPU, Clostridium spp. CCE, and Bacteroidales CCE. Overall, the factors associated with FIO concentrations in sand were related to the sand-water interface (i.e., sand-wetting) and included daily average densities of FIOs in water, rainfall, and wave height Targeted monitoring that focuses on daily trends of sand FIO variability, combined with information about specific water quality, weather, and environmental factors may inform beach monitoring and management decisions to reduce microbial burdens in beach sand. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Heaney, Christopher D.; Exum, Natalie G.; Schwab, Kellogg J.; Love, David C.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Heaney, Christopher D.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Wade, Timothy J.] US EPA, Epidemiol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Dufour, Alfred P.; Brenner, Kristen P.; Haugland, Richard A.; Chern, Eunice] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Serre, Marc L.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Noble, Rachel] Univ N Carolina, Inst Marine Sci, Morehead City, NC 28557 USA.
RP Heaney, CD (reprint author), Dept Environm Hlth Sci, 615 N Wolfe St, Baltimore, MD 21205 USA.
EM cheaney@jhsph.edu
OI serre, marc/0000-0003-3145-4024
FU University of North Carolina, Department of Environmental Sciences and
Engineering/U.S. Environmental Protection Agency Cooperative Training in
Environmental Sciences Research EPA [CR83323601]; National Institute of
Environmental Health Sciences at the UNC Department of Biostatistics
[T32 ES007018]; W.K. Kellogg Health Scholar-Community Track at the UNC
Center for Health Promotion and Disease Prevention; National Science
Foundation Integrative Graduate Education and Research Traineeship in
Water, Climate and Health [1069213]; Osprey Foundation of Maryland
[1602030014]
FX The authors thank Mark Sobsey for the use of his laboratory to perform
sand analyses and the provision of E. coli Famp host
bacteria. We thank Elizabeth Hilborn at EPA for reviewing the
manuscript. CDH designed and performed laboratory experiments, took part
in field sampling efforts, performed statistical analyses, and wrote and
edited the manuscript. DCL advised and assisted in coliphage methods
development and edited the manuscript. CDH, TW, ES, AD, KB, RH, LW and
EC designed and implemented the field data collection efforts. KB, RH,
EC and AD designed testing protocols for FIB. TW provided consultation
on statistical modeling. CDH received support through the University of
North Carolina, Department of Environmental Sciences and
Engineering/U.S. Environmental Protection Agency Cooperative Training in
Environmental Sciences Research EPA CR83323601, the National Institute
of Environmental Health Sciences environmental epidemiology training
grant (T32 ES007018) at the UNC Department of Biostatistics, and W.K.
Kellogg Health Scholar-Community Track at the UNC Center for Health
Promotion and Disease Prevention. KS advised and edited the manuscript.
NGE received support through the National Science Foundation Integrative
Graduate Education and Research Traineeship in Water, Climate and Health
(award ID 1069213) and the Osprey Foundation of Maryland (award ID
1602030014).
NR 60
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U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 1
PY 2014
VL 497
BP 440
EP 447
DI 10.1016/j.scitotenv.2014.07.113
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GM
UT WOS:000343613100046
PM 25150738
ER
PT J
AU Wang, DX
Hu, JL
Xu, Y
Lv, D
Xie, XY
Kleeman, M
Xing, J
Zhang, HL
Ying, Q
AF Wang, Dexiang
Hu, Jianlin
Xu, Yong
Lv, Di
Xie, Xiaoyang
Kleeman, Michael
Xing, Jia
Zhang, Hongliang
Ying, Qi
TI Source contributions to primary and secondary inorganic particulate
matter during a severe wintertime PM2.5 pollution episode in Xi'an,
China
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Xi'an; Source apportionment; Particulate matter; WRF/CMAQ; EDGAR
ID PEARL RIVER DELTA; AIR-QUALITY MODEL; ORGANIC AEROSOL FORMATION;
CHEMICAL-TRANSPORT MODEL; SOURCE APPORTIONMENT; SOUTHEAST TEXAS;
WRF/CHEM MODEL; BOUNDARY-LAYER; PM10; CALIFORNIA
AB Average PM2.5 concentrations of similar to 250 mu g m(-3) and peak concentrations of similar to 500 mu g m(-3) were observed in Xi'an, the largest city in Northwest China during an extreme event in January 2013. The source-oriented versions of the Community Multi-scale Air Quality (CMAQ) model with anthropogenic emissions from Emissions Database for Global Atmospheric Research (EDGAR) were used to study the source contributions of six different source categories including energy production, industries, transportation, residential activities, "other" (agriculture, biomass, waste burning, and biogenic sources), and windblown dust to primary and secondary inorganic PM2.5 (nitrate and sulfate) during this episode. The model generally captured the variation and magnitude of PM2.5 concentrations at monitoring sites. The monthly average concentration of the predicted PM2.5 in Xi'an was >200 mu g m(-3), comparing favorably with the measurement of similar to 250 mu g m(-3). Predicted concentrations of elemental carbon (EC), organic aerosol (OA), sulfate, nitrate, and ammonium were 6, 35, 18, 22, and 12 mu g m(-3), respectively. Chemically unresolved PM2.5 components (PM2.5 Other) were similar to 80 mu g m(-3). Industries and residential activities dominated EC, organic carbon (OC) and PM2.5 Other, contributing 85%, 95%, and 83%, respectively. Energy production (mainly coal combustion) was the dominating source for secondary nitrate, contributing 46%. Other local and upwind sources were also important, contributing 43% and 11% of total nitrate, respectively. Primary sulfate was similar to 10 mu g m(-3) in vicinity surrounding point sources. Secondary sulfate from upwind sources was also important with concentrations of similar to 4-5 mu g m(-3). Secondary sulfate formed by SO2 emitted from local sources was dominated by energy production. Based on the contributions of different sources to primary components and secondary nitrate and sulfate, the contributions of different sources to PM2.5 total mass in Xi'an during the extremely polluted months are: energy 5%, industries 58%, transportation 2%, residential activities 16%, dust 4%, and other (including other components, inexplicit sources, and upwind sources) 15%. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Wang, Dexiang; Xu, Yong; Lv, Di; Xie, Xiaoyang] Northwest A&F Univ, Coll Forestry, Yangling 712100, Shaanxi, Peoples R China.
[Hu, Jianlin; Kleeman, Michael; Zhang, Hongliang] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA.
[Xing, Jia] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Zhang, Hongliang] Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA.
[Ying, Qi] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA.
RP Zhang, HL (reprint author), Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA.
EM tamzhang@ucdavis.edu; qying@civil.tamu.edu
RI xing, jia/O-1784-2014; Zhang, Hongliang/C-2499-2012; Hu,
Jianlin/C-2023-2014
OI Hu, Jianlin/0000-0001-7709-439X
FU '948' project from the State Forestry Administration of China
[2013-4-56]
FX This study is supported by the '948' project from the State Forestry
Administration of China (grant #2013-4-56). The authors thank the Texas
A&M Supercomputing Facility (http://sc.tamu.edu) and the Texas Advanced
Computing Center (http://www.tacc.utexas.edu/) for providing computing
resources.
NR 66
TC 13
Z9 14
U1 10
U2 136
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD NOV
PY 2014
VL 97
SI SI
BP 182
EP 194
DI 10.1016/j.atmosenv.2014.08.020
PG 13
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AR1HQ
UT WOS:000343336700022
ER
PT J
AU Schulte, N
Snyder, M
Isakov, V
Heist, D
Venkatram, A
AF Schulte, Nico
Snyder, Michelle
Isakov, Vlad
Heist, David
Venkatram, Akula
TI Effects of solid barriers on dispersion of roadway emissions
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Barrier; Air quality; Dispersion modeling; Roadway; Line source
ID NOISE BARRIERS; AIR-QUALITY; POLLUTION; PARTICLES
AB Several studies have found that exposure to traffic-generated air pollution is associated with several adverse health effects. Field studies, laboratory experiments, and numerical simulations indicate that roadside barriers represent a practical method of mitigating the impact of vehicle emissions because near road concentrations are significantly reduced downwind of a barrier relative to concentrations in the absence of a barrier. These studies also show that the major effects of barriers on concentrations are: 1) the concentration is well mixed over a height roughly proportional to the barrier height, and this effect persists over several barrier heights downwind, 2) the turbulence that spreads the plume vertically is increased downwind of the barrier, 3) the pollutant is lofted above the top of the barrier. This paper ties these effects together using two semi-empirical dispersion models. These models provide good descriptions of concentrations measured in a wind tunnel study and a tracer field study. Their performance is best during neutral and stable conditions. The models overestimate concentrations near the barrier during unstable conditions. We illustrate an application of these models by estimating the effect of barrier height on concentrations during neutral, stable, and unstable conditions. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Schulte, Nico; Venkatram, Akula] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
[Snyder, Michelle; Isakov, Vlad; Heist, David] US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
RP Venkatram, A (reprint author), Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
EM venky@engr.ucr.edu
FU South Coast Air Quality Management District
FX We thank the South Coast Air Quality Management District for funding
this research and the U.S. EPA for providing the wind tunnel and Idaho
Falls data.
NR 17
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U1 3
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD NOV
PY 2014
VL 97
SI SI
BP 286
EP 295
DI 10.1016/j.atmosenv.2014.08.026
PG 10
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AR1HQ
UT WOS:000343336700031
ER
PT J
AU Sinsabaugh, RL
Belnap, J
Findlay, SG
Shah, JJF
Hill, BH
Kuehn, KA
Kuske, CR
Litvak, ME
Martinez, NG
Moorhead, DL
Warnock, DD
AF Sinsabaugh, Robert L.
Belnap, Jayne
Findlay, Stuart G.
Shah, Jennifer J. Follstad
Hill, Brian H.
Kuehn, Kevin A.
Kuske, Cheryl R.
Litvak, Marcy E.
Martinez, Noelle G.
Moorhead, Daryl L.
Warnock, Daniel D.
TI Extracellular enzyme kinetics scale with resource availability
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Ecological stoichiometry; Extracellular enzymes; Enzyme kinetics;
Microbial community; Microbial metabolism
ID SOIL ORGANIC-MATTER; CARBON-MONOXIDE CONSUMPTION; METHANE-OXIDIZING
BACTERIA; ECOENZYMATIC STOICHIOMETRY; RIVERINE BACTERIOPLANKTON;
TEMPERATURE SENSITIVITY; EXOPROTEOLYTIC ACTIVITY; THEORETICAL-MODEL;
TROPHIC GRADIENT; SIZE FRACTIONS
AB Microbial community metabolism relies on external digestion, mediated by extracellular enzymes that break down complex organic matter into molecules small enough for cells to assimilate. We analyzed the kinetics of 40 extracellular enzymes that mediate the degradation and assimilation of carbon, nitrogen and phosphorus by diverse aquatic and terrestrial microbial communities (1160 cases). Regression analyses were conducted by habitat (aquatic and terrestrial), enzyme class (hydrolases and oxidoreductases) and assay methodology (low affinity and high affinity substrates) to relate potential reaction rates to substrate availability. Across enzyme classes and habitats, the scaling relationships between apparent V-max and apparent K-m followed similar power laws with exponents of 0.44 to 0.67. These exponents, called elasticities, were not statistically distinct from a central value of 0.50, which occurs when the K-m of an enzyme equals substrate concentration, a condition optimal for maintenance of steady state. We also conducted an ecosystem scale analysis of ten extracellular hydrolase activities in relation to soil and sediment organic carbon (2,000-5,000 cases/enzyme) that yielded elasticities near 1.0 (0.9 +/- A 0.2, n = 36). At the metabolomic scale, the elasticity of extracellular enzymatic reactions is the proportionality constant that connects the C:N:P stoichiometries of organic matter and ecoenzymatic activities. At the ecosystem scale, the elasticity of extracellular enzymatic reactions shows that organic matter ultimately limits effective enzyme binding sites. Our findings suggest that one mechanism by which microbial communities maintain homeostasis is regulating extracellular enzyme expression to optimize the short-term responsiveness of substrate acquisition. The analyses also show that, like elemental stoichiometry, the fundamental attributes of enzymatic reactions can be extrapolated from biochemical to community and ecosystem scales.
C1 [Sinsabaugh, Robert L.; Litvak, Marcy E.; Martinez, Noelle G.; Warnock, Daniel D.] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
[Belnap, Jayne] US Geol Survey, Southwest Biol Sci Ctr, Moab, UT 84532 USA.
[Findlay, Stuart G.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA.
[Shah, Jennifer J. Follstad] Utah State Univ, Watershed Sci Dept, Logan, UT 84322 USA.
[Hill, Brian H.] US EPA, Natl Hlth & Environm Effects Lab, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA.
[Kuehn, Kevin A.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA.
[Kuske, Cheryl R.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM USA.
[Moorhead, Daryl L.] Univ Toledo, Dept Environm Sci, Toledo, OH 43606 USA.
RP Sinsabaugh, RL (reprint author), Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
EM rlsinsab@unm.edu
FU NSF Ecosystem Sciences program [DEB-0918718]; Sevilleta LTER Program;
NSF [DEB-0315686, DBI-0420965, DBI-0521018]; Michigan Sea Grant College
Program under NOAA [NA76RG0133]; DOE BER Science Focus Area grant; DOE
BER [DE-SC0008088]
FX RLS acknowledges support from the NSF Ecosystem Sciences program
(DEB-0918718) and the Sevilleta LTER Program. KAK acknowledges support
from NSF (DEB-0315686, DBI-0420965, DBI-0521018) and the Michigan Sea
Grant College Program (NA76RG0133) under NOAA. CRK acknowledges support
from a DOE BER Science Focus Area grant. MEL and RLS acknowledge support
from DOE BER Grant number DE-SC0008088. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use.
NR 94
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U1 22
U2 123
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
EI 1573-515X
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD NOV
PY 2014
VL 121
IS 2
BP 287
EP 304
DI 10.1007/s10533-014-0030-y
PG 18
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA AQ9BL
UT WOS:000343135800001
ER
PT J
AU Fisher, WS
Fore, LS
Oliver, LM
Lobue, C
Quarles, R
Campbell, J
Harris, P
Hemmer, B
Vickery, S
Parsons, M
Hutchins, A
Bernier, K
Rodriguez, D
Bradley, P
AF Fisher, William S.
Fore, Leska S.
Oliver, Leah M.
Lobue, Charles
Quarles, Robert
Campbell, Jed
Harris, Peggy
Hemmer, Becky
Vickery, Sherry
Parsons, Mel
Hutchins, Aaron
Bernier, Kent
Rodriguez, Danny
Bradley, Patricia
TI Regional status assessment of stony corals in the US Virgin Islands
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Stony coral condition; Reef assessments; Regulatory protection; Clean
Water Act; Biological criteria; Biocriteria; Probability-based sampling
ID REEF FISH COMMUNITIES; COLONY SURFACE-AREA; CLEAN-WATER-ACT; ECOLOGICAL
INTEGRITY; HABITAT COMPLEXITY; NATURAL-RESOURCES; BASE-LINES;
ATTRIBUTES; MANAGEMENT; IMPACT
AB States may protect coral reefs using biological water quality standards outlined by the Clean Water Act. This requires biological assessments with indicators sensitive to human disturbance and regional, probability-based survey designs. Stony coral condition was characterized on a regional scale for the first time in the nearshore waters of the US Virgin Islands (USVI). Coral composition, abundance, size, and health were assessed at 66 stations in the St. Croix region in fall 2007 and at 63 stations in the St. Thomas and St. John region in winter 2009. Indicators were chosen for their sensitivity to human disturbance. Both surveys were probability-based (random) designs with station locations preselected from areas covered by hardbottom and coral reef substrate. Taxa richness was as high as 21 species but more than half the area of both regions exhibited taxa richness of < 10 species in the 25 m(2) transect area. Coral density was as high as 5 colonies m(-2) but more than half the area of both regions had < 2 colonies m(-2). Both regions showed similar dominant species based on frequency of occurrence and relative abundance. Because of large colony sizes, Montastrea annularis provided more total surface area and live surface area than more abundant species. The surveys establish baseline regional conditions and provide a foundation for long-term regional monitoring envisioned by the USVI Department of Planning and Natural Resources. The probabilistic sampling design assures the data can be used in Clean Water Act reporting.
C1 [Fisher, William S.; Oliver, Leah M.; Quarles, Robert; Campbell, Jed; Harris, Peggy; Hemmer, Becky; Vickery, Sherry] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Fore, Leska S.] Stat Design, Seattle, WA 98107 USA.
[Lobue, Charles] US EPA, New York, NY 10007 USA.
[Parsons, Mel] US EPA, Athens, GA 30605 USA.
[Hutchins, Aaron; Bernier, Kent] USVI Dept Planning & Nat Resources, Frederiksted, VI 00840 USA.
[Rodriguez, Danny] US EPA, Vieques, PR 00765 USA.
[Bradley, Patricia] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Fisher, WS (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM fisher.william@epa.gov
FU Safe and Sustainable Waters Research Program of US EPA Office of
Research and Development [ORD-006591]
FX The EPA Coral Reef Assessment Team is grateful for the vision, support,
and commitment of Kennard Potts (EPA Office of Water) for advancing the
development of coral reef biocriteria. We also recognize the efforts of
many coworkers and divers on the USVI surveys, including Alan Humphrey,
Dan Cooke, Richard Henry, John McBurney, Scott Grossman, Heidi Bell,
Valerie Chan, Alexandra Holocek, Jeanne Brown, and the captain and crew
of EPA's Ocean Survey Vessel BOLD. Dr. Pamela Hallock-Muller (University
of South Florida) provided analyses of Foraminiferal assemblages, and we
appreciate the collaboration of USVI Department of Planning and
Resources, particularly the efforts of Anita Nibbs and Dr. Norrine
Noorhasen. This research was supported through the Safe and Sustainable
Waters Research Program of US EPA Office of Research and Development
(contribution ORD-006591).
NR 67
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U1 3
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD NOV
PY 2014
VL 186
IS 11
BP 7165
EP 7181
DI 10.1007/s10661-014-3918-z
PG 17
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AQ8CU
UT WOS:000343051400014
PM 25052328
ER
PT J
AU Shin, HH
Fann, N
Burnett, RT
Cohen, A
Hubbell, BJ
AF Shin, Hwashin H.
Fann, Neal
Burnett, Richard T.
Cohen, Aaron
Hubbell, Bryan J.
TI Outdoor Fine Particles and Nonfatal Strokes Systematic Review and
Meta-analysis
SO EPIDEMIOLOGY
LA English
DT Article
ID AMBIENT AIR-POLLUTION; LONG-TERM EXPOSURE; EMERGENCY-DEPARTMENT VISITS;
AMERICAN-HEART-ASSOCIATION; PARTICULATE MATTER; HOSPITAL ADMISSIONS;
GLOBAL BURDEN; CARDIOVASCULAR-DISEASE; ISCHEMIC-STROKE; RISK-ASSESSMENT
AB Background: Epidemiologic studies find that long-and short-term exposure to fine particles (PM2.5) is associated with adverse cardiovascular outcomes, including ischemic and hemorrhagic strokes. However, few systematic reviews or meta-analyses have synthesized these results.
Methods: We reviewed epidemiologic studies that estimated the risks of nonfatal strokes attributable to ambient PM2.5. To pool risks among studies we used a random-effects model and 2 Bayesian approaches. The first Bayesian approach assumes a normal prior that allows risks to be zero, positive or negative. The second assumes a gamma prior, where risks can only be positive. This second approach is proposed when the number of studies pooled is small, and there is toxicological or clinical literature to support a causal relation.
Results: We identified 20 studies suitable for quantitative meta-analysis. Evidence for publication bias is limited. The frequentist meta-analysis produced pooled risk ratios of 1.06 (95% confidence interval = 1.00-1.13) and 1.007 (1.003-1.010) for long-and short-term effects, respectively. The Bayesian meta-analysis found a posterior mean risk ratio of 1.08 (95% posterior interval = 0.96-1.26) and 1.008 (1.003-1.013) from a normal prior, and of 1.05 (1.02-1.10) and 1.008 (1.004-1.013) from a gamma prior, for long-and short-term effects, respectively, per 10 mu g/m(3) PM2.5.
Conclusions: Sufficient evidence exists to develop a concentration-response relation for short-and long-term exposures to PM2.5 and stroke incidence. Long-term exposures to PM2.5 result in a higher risk ratio than short-term exposures, regardless of the pooling method. The evidence for short-term PM2.5-related ischemic stroke is especially strong.
C1 [Shin, Hwashin H.; Burnett, Richard T.] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada.
[Shin, Hwashin H.] Queens Univ, Dept Math & Stat, Kingston, ON K7L 3N6, Canada.
[Fann, Neal; Hubbell, Bryan J.] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Cohen, Aaron] Hlth Effects Inst, Boston, MA USA.
RP Fann, N (reprint author), US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, C504-02, Res Triangle Pk, NC 27711 USA.
EM fann.neal@epa.gov
OI Fann, Neal/0000-0002-6724-8575
NR 47
TC 6
Z9 6
U1 4
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD NOV
PY 2014
VL 25
IS 6
BP 835
EP 842
DI 10.1097/EDE.0000000000000162
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AQ8XJ
UT WOS:000343122000008
PM 25188557
ER
PT J
AU Beck, MW
Tomcko, CM
Valley, RD
Staples, DF
AF Beck, Marcus W.
Tomcko, Cynthia M.
Valley, Ray D.
Staples, David F.
TI Analysis of macrophyte indicator variation as a function of sampling,
temporal, and stressor effects
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Climate; Development; Lake monitoring; Macrophytes; Power; Variation
ID BIOTIC INTEGRITY; SUBMERGED MACROPHYTES; MINNESOTA LAKES; EUROPEAN
LAKES; INDEX; PERFORMANCE
AB Biological indicators that signal changes in lake condition are essential tools for guiding resource management decisions. Macrophyte-based indicators have traditionally been selected and evaluated in the context of nutrient-based stressors, although the need to evaluate indicators that are sensitive to climate stressors has been increasingly relevant. Moreover, indicators should ideally exhibit minimal sampling variation and have low natural temporal variation so there is high power to detect changes in the mean value over time. Eight macrophyte indicators were estimated in 23 Minnesota (USA) lakes using four years of repeated surveys to estimate sampling and temporal variation, response to development (phosphorus concentration) and climate stress (annual growing degree days), and power to detect significant change at various annual sampling intervals. Indicators included a macrophyte index of biotic integrity, floristic quality index, maximum depth of growth, total species richness, common species richness, mean richness, and frequency occurrence of rooted species and Chara sp. Overall, regression and smoothed additive models indicated significant relationships of indicators to total lake phosphorus and mean annual growing degree days. The macrophyte index of biotic integrity, floristic quality index, and the frequency rooted species had minimal sampling variation in this study, were responsive to development or climate stress, and had low annual variation (coefficients of variation 0.08, 0.10, and 0.19, respectively) resulting in high to moderate power (>50%) for detecting significant change over a 20 year period. Results from these analyses will facilitate the use of precise and powerful indicators that respond to stressors that are of concern for the management of freshwater glacial lakes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Beck, Marcus W.] Univ Minnesota, Conservat Biol Grad Program, St Paul, MN 55108 USA.
[Tomcko, Cynthia M.] Minnesota Dept Nat Resources, Div Fisheries & Wildlife, Grand Rapids, MN 55744 USA.
[Valley, Ray D.] Minnesota Dept Nat Resources, Div Fisheries & Wildlife, St Paul, MN 55744 USA.
[Staples, David F.] Minnesota Dept Nat Resources, Div Fisheries & Wildlife, Forest Lake, MN 55025 USA.
RP Beck, MW (reprint author), US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM beck.marcus@epa.gov; cindy.tomcko@state.mn.us; ray.valley@navico.com;
david.staples@state.mn.us
NR 33
TC 3
Z9 3
U1 2
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
EI 1872-7034
J9 ECOL INDIC
JI Ecol. Indic.
PD NOV
PY 2014
VL 46
BP 323
EP 335
DI 10.1016/j.ecolind.2014.07.002
PG 13
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AQ2YO
UT WOS:000342656100034
ER
PT J
AU Garrison, AW
Cyterski, M
Roberts, KD
Burdette, D
Williamson, J
Avants, JK
AF Garrison, A. W.
Cyterski, M.
Roberts, K. D.
Burdette, D.
Williamson, J.
Avants, J. K.
TI Occurrences and fate of DDT principal isomers/metabolites, DDA, and o,p
'-DDD enantiomers in fish, sediment and water at a DDT-impacted
superfund site
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE DDT; DDD; DDT/fish/sediment/water; o,p '-DDD EF; DDA
ID ORGANOCHLORINE PESTICIDES; SOUTH CHINA; BIS(CHLOROPHENYL)ACETIC ACID;
GAS-CHROMATOGRAPHY; ESTROGEN-RECEPTOR; RIVER DELTA; RESIDUES; SOILS;
METABOLITES; CONTAMINANTS
AB f In the 1950s and 60s, discharges from a DDT manufacturing plant contaminated a tributary system of the Tennessee River near Huntsville, Alabama, USA. Regulatory action resulted in declaring the area a Superfund site which required remediation and extensive monitoring. Monitoring data collected from 1988, after remediation, through 2011 showed annual decreases approximating first-order decay in concentrations of total DDT and its six principal congeners (p,p'-DDT, o,p'-DDT, p,p'-DDD, o,p'-DDD, p,p'-DDE and o,p'-DDE) in filets from three species of fish. As of 2013, these concentrations met the regulatory requirements of 5 mg/kg or less total DDT for each fish tested. The enantiomer fractions (EF) of chiral o,p'-DDD in smallmouth buffalo and channel catfish were always below 0.5, indicating preferential decay of the (+)-enantiomer of this congener; this EF did not change significantly over 15 years. The often-neglected DDT metabolite p,p'-DDA was found at a concentration of about 20 mu g/l in the ecosystem water. Published by Elsevier Ltd.
C1 [Garrison, A. W.; Cyterski, M.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Roberts, K. D.] Olin Corp, Environm Remediat Grp, Cleveland, TN 37323 USA.
[Burdette, D.; Williamson, J.] US EPA, Sci & Ecosyst Support Div, Athens, GA 30605 USA.
[Avants, J. K.] US EPA, Senior Serv Amer, Athens, GA 30605 USA.
RP Garrison, AW (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM garrison.wayne@epa.gov
NR 44
TC 2
Z9 2
U1 4
U2 54
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD NOV
PY 2014
VL 194
BP 224
EP 234
DI 10.1016/j.envpol.2014.07.025
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AQ1GV
UT WOS:000342530800028
PM 25150505
ER
PT J
AU Magnuson, M
Ernst, H
Griggs, J
Fitz-James, S
Mapp, L
Mullins, M
Nichols, T
Shah, S
Smith, T
Hedrick, E
AF Magnuson, Matthew
Ernst, Hiba
Griggs, John
Fitz-James, Schatzi
Mapp, Latisha
Mullins, Marissa
Nichols, Tonya
Shah, Sanjiv
Smith, Terry
Hedrick, Elizabeth
TI Analysis of environmental contamination resulting from catastrophic
incidents: Part 1. Building and sustaining capacity in laboratory
networks
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Catastrophe; Environmental analysis; Laboratory networks; Laboratory
capacity; Resilience; Sustainability
ID SECURITY; RISK
AB Catastrophic incidents, such as natural disasters, terrorist attacks, and industrial accidents, can occur suddenly and have high impact. However, they often occur at such a low frequency and in unpredictable locations that planning for the management of the consequences of a catastrophe can be difficult. For those catastrophes that result in the release of contaminants, the ability to analyze environmental samples is critical and contributes to the resilience of affected communities. Analyses of environmental samples are needed to make appropriate decisions about the course of action to restore the area affected by the contamination. Environmental samples range from soil, water, and air to vegetation, building materials, and debris. In addition, processes used to decontaminate any of these matrices may also generate wastewater and other materials that require analyses to determine the best course for proper disposal. This paper summarizes activities and programs the United States Environmental Protection Agency (USEPA) has implemented to ensure capability and capacity for the analysis of contaminated environmental samples following catastrophic incidents. USEPA's focus has been on building capability for a wide variety of contaminant classes and on ensuring national laboratory capacity for potential surges in the numbers of samples that could quickly exhaust the resources of local communities. USEPA's efforts have been designed to ensure a strong and resilient laboratory infrastructure in the United States to support communities as they respond to contamination incidents of any magnitude. The efforts include not only addressing technical issues related to the best-available methods for chemical, biological, and radiological contaminants, but also include addressing the challenges of coordination and administration of an efficient and effective response. Laboratory networks designed for responding to large scale contamination incidents can be sustained by applying their resources during incidents of lesser significance, for special projects, and for routine surveillance and monitoring as part of ongoing activities of the environmental laboratory community. Published by Elsevier Ltd.
C1 [Magnuson, Matthew; Ernst, Hiba; Nichols, Tonya; Shah, Sanjiv] US EPA, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA.
[Griggs, John] US EPA, Off Air & Radiat, Nat Analyt Radiat Environm Lab, Washington, DC USA.
[Fitz-James, Schatzi] US EPA, Off Solid Waste & Emergency Response, Off Resource Conservat & Recovery, Mat Recovery & Waste Management Div, Washington, DC USA.
[Mapp, Latisha; Hedrick, Elizabeth] US EPA, Off Water, Water Secur Div, Washington, DC USA.
[Mullins, Marissa; Smith, Terry] US EPA, Off Solid Waste & Emergency Response, Off Emergency Management, CBRN Consequence Management Advisory Team, Washington, DC USA.
RP Magnuson, M (reprint author), US EPA, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA.
FU U.S. Environmental Protection Agency (USEPA), through its Office of
Research and Development
FX The U.S. Environmental Protection Agency (USEPA), through its Office of
Research and Development, performed, managed, funded, and/or
collaborated in the research described herein. This content has been
peer and administratively reviewed and has been approved for
publication. Note that approval does not signify that the contents
necessarily reflect the views of the USEPA. Reference herein to any
specific commercial product, process, or service by trade name,
trademark, manufacturer, or otherwise does not necessarily constitute or
imply its endorsement, recommendation, or favoring by the United States
government. The views and opinions expressed herein do not necessarily
state or reflect those of the United States government and shall not be
used for advertising or product endorsement purposes.
NR 18
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U1 1
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2014
VL 72
SI SI
BP 83
EP 89
DI 10.1016/j.envint.2014.01.015
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OB
UT WOS:000341470300010
PM 24534702
ER
PT J
AU Magnuson, M
Campisano, R
Griggs, J
Fitz-James, S
Hall, K
Mapp, L
Mullins, M
Nichols, T
Shah, S
Silvestri, E
Smith, T
Willison, S
Ernst, H
AF Magnuson, Matthew
Campisano, Romy
Griggs, John
Fitz-James, Schatzi
Hall, Kathy
Mapp, Latisha
Mullins, Marissa
Nichols, Tonya
Shah, Sanjiv
Silvestri, Erin
Smith, Terry
Willison, Stuart
Ernst, Hiba
TI Analysis of environmental contamination resulting from catastrophic
incidents: Part 2. Building laboratory capability by selecting and
developing analytical methodologies
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Analytical methods; Catastrophe; Innovation; Laboratory analysis;
Laboratory capacity; Sustainability
ID DRINKING-WATER; NERVE AGENT; SAMPLES; LIVE; VX
AB Catastrophic incidents can generate a large number of samples of analytically diverse types, including forensic, clinical, environmental, food, and others. Environmental samples include water, wastewater, soil, air, urban building and infrastructure materials, and surface residue. Such samples may arise not only from contamination from the incident but also from the multitude of activities surrounding the response to the incident, including decontamination. This document summarizes a range of activities to help build laboratory capability in preparation for sample analysis following a catastrophic incident, including selection and development of fit-for-purpose analytical methods for chemical, biological, and radiological contaminants. Fit-for-purpose methods are those which have been selected to meet project specific data quality objectives. For example, methods could be fit for screening contamination in the early phases of investigation of contamination incidents because they are rapid and easily implemented, but those same methods may not be fit for the purpose of remediating the environment to acceptable levels when a more sensitive method is required. While the exact data quality objectives defining fitness-for-purpose can vary with each incident, a governing principle of the method selection and development process for environmental remediation and recovery is based on achieving high throughput while maintaining high quality analytical results. This paper illustrates the result of applying this principle, in the form of a compendium of analytical methods for contaminants of interest. The compendium is based on experience with actual incidents, where appropriate and available. This paper also discusses efforts aimed at adaptation of existing methods to increase fitness-for-purpose and development of innovative methods when necessary. The contaminants of interest are primarily those potentially released through catastrophes resulting from malicious activity. However, the same techniques discussed could also have application to catastrophes resulting from other incidents, such as natural disasters or industrial accidents. Further, the high sample throughput enabled by the techniques discussed could be employed for conventional environmental studies and compliance monitoring, potentially decreasing costs and/or increasing the quantity of data available to decision-makers. Published by Elsevier Ltd.
C1 [Magnuson, Matthew; Campisano, Romy; Hall, Kathy; Nichols, Tonya; Shah, Sanjiv; Silvestri, Erin; Willison, Stuart; Ernst, Hiba] US EPA, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA.
[Griggs, John] US EPA, Off Air & Radiat, Natl Analyt Radiat Environm Lab, Washington, DC USA.
[Fitz-James, Schatzi] US EPA, Off Solid Waste & Emergency Response, Off Resource Conservat & Recovery, Mat Recovery & Waste Management Div, Washington, DC USA.
[Mapp, Latisha] US EPA, Off Water, Water Secur Div, Washington, DC USA.
[Mullins, Marissa; Smith, Terry] US EPA, Off Solid Waste & Emergency Response, Off Emergency Management, CBRN Consequence Management Advisory Team, Washington, DC USA.
RP Magnuson, M (reprint author), US EPA, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA.
FU U.S. Environmental Protection Agency (USEPA), through its Office of
Research and Development
FX The U.S. Environmental Protection Agency (USEPA), through its Office of
Research and Development, performed, managed, funded, and/or
collaborated in the research described herein. This content has been
peer and administratively reviewed and has been approved for
publication. Note that approval does not signify that the contents
necessarily reflect the views of the USEPA. Reference herein to any
specific commercial product, process, or service by trade name,
trademark, manufacturer, or otherwise does not necessarily constitute or
imply its endorsement, recommendation, or favoring by the United States
government. The views and opinions expressed herein do not necessarily
state or reflect those of the United States government and shall not be
used for advertising or product endorsement purposes.
NR 29
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Z9 3
U1 0
U2 33
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2014
VL 72
SI SI
BP 90
EP 97
DI 10.1016/j.envint.2014.01.021
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OB
UT WOS:000341470300011
PM 24568927
ER
PT J
AU Szabo, J
Minamyer, S
AF Szabo, Jeff
Minamyer, Scott
TI Decontamination of chemical agents from drinking water infrastructure: A
literature review and summary
SO ENVIRONMENT INTERNATIONAL
LA English
DT Review
DE Chemicals; Drinking water; Infrastructure; Decontamination
ID ORGANOPHOSPHORUS PESTICIDES; DISTRIBUTION-SYSTEM; ACCUMULATION;
DEGRADATION; CHLORINATION; ADSORPTION; ARSENATE; ARSENITE; PATHWAYS;
BIOFILMS
AB This report summarizes the current state of knowledge on the persistence of chemical contamination on drinking water infrastructure (such as pipes) along with information on decontamination should persistence occur. Decontamination options for drinking water infrastructure have been explored for some chemical contaminants, but important data gaps remain. In general, data on chemical persistence on drinking water infrastructure is available for inorganics such as arsenic and mercury, as well as select organics such as petroleum products, pesticides and rodenticides. Data specific to chemical warfare agents and pharmaceuticals was not found and data on toxins is scant Future research suggestions focus on expanding the available chemical persistence data to other common drinking water infrastructure materials. Decontaminating agents that successfully removed persistent contamination from one infrastructure material should be used in further studies. Methods for sampling or extracting chemical agents from water infrastructure surfaces are needed. Published by Elsevier Ltd.
C1 [Szabo, Jeff; Minamyer, Scott] US EPA, Natl Homeland Secur Res Ctr NG 16, Cincinnati, OH 45268 USA.
RP Szabo, J (reprint author), US EPA, Natl Homeland Secur Res Ctr NG 16, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM szabo.jeff@epa.gov
NR 31
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U1 10
U2 110
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2014
VL 72
SI SI
BP 119
EP 123
DI 10.1016/j.envint.2014.01.025
PG 5
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OB
UT WOS:000341470300014
PM 24565672
ER
PT J
AU Szabo, J
Minamyer, S
AF Szabo, Jeff
Minamyer, Scott
TI Decontamination of biological agents from drinking water infrastructure:
A literature review and summary
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Bacteria; Spores; Viruses; Drinking water; Infrastructure;
Decontamination
ID DISTRIBUTION PIPE BIOFILMS; LEGIONELLA-PNEUMOPHILA; DISTRIBUTION-SYSTEM;
ESCHERICHIA-COLI; BACILLUS SPORES; ENHANCED DECONTAMINATION; CHLORINE
INACTIVATION; CORRODED IRON; POROUS-MEDIA; PILOT-SCALE
AB This report summarizes the current state of knowledge on the persistence of biological agents on drinking water infrastructure (suchas pipes) along with information on decontamination should persistence occur. Decontamination options for drinking water infrastructure have been explored for some biological agents, but data gaps remain. Data on bacterial spore persistence on common water infrastructure materials such as iron and cement-mortar lined iron show that spores can be persistent for weeks after contamination. Decontamination data show that common disinfectants such as free chlorine have limited effectiveness. Decontamination results with germinant and alternate disinfectants such as chlorine dioxide are more promising. Persistence and decontamination data were collected on vegetative bacteria, such as coliforms, Legionella and Salmonella. Vegetative bacteria are less persistent than spores and more susceptible to disinfection, but the surfaces and water quality conditions in many studies were only marginally related to drinking water systems. However, results of real-world case studies on accidental contamination of water systems with E. coli and Salmonella contamination show that flushing and chlorination can help return a water system to service. Some viral persistence data were found, but decontamination data were lacking. Future research suggestions focus on expanding the available biological persistence data to other common infrastructure materials. Further exploration of non-traditional drinking water disinfectants is recommended for future studies. (C) Published by Elsevier Ltd.
C1 [Szabo, Jeff; Minamyer, Scott] US EPA, Natl Homeland Secur Res Ctr NG 16, Cincinnati, OH 45268 USA.
RP Szabo, J (reprint author), US EPA, Natl Homeland Secur Res Ctr NG 16, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM szabo.jeff@epa.gov
NR 57
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Z9 6
U1 6
U2 74
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2014
VL 72
SI SI
BP 124
EP 128
DI 10.1016/j.envint.2014.01.031
PG 5
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OB
UT WOS:000341470300015
PM 24548733
ER
PT J
AU Szabo, J
Minamyer, S
AF Szabo, Jeff
Minamyer, Scott
TI Decontamination of radiological agents from drinking water
infrastructure: A literature review and summary
SO ENVIRONMENT INTERNATIONAL
LA English
DT Review
DE Cesium; Strontium; Cobalt; Drinking water; Infrastructure;
Decontamination
ID RAY-ABSORPTION-SPECTROSCOPY; TANK-WASTE LEACHATE; PIPE-SCALE DEPOSITS;
DISTRIBUTION-SYSTEMS; STRONTIUM UPTAKE; FE(III) OXIDE; ADSORPTION;
SORPTION; CESIUM; KAOLINITE
AB This report summarizes the current state of knowledge on the persistence of radiological agents on drinking water infrastructure (such as pipes) along with information on decontamination should persistence occur. Decontamination options for drinking water infrastructure have been explored for some important radiological agents (cesium, strontium and cobalt), but important data gaps remain. Although some targeted experiments have been published on cesium, strontium and cobalt persistence on drinking water infrastructure, most of the data comes from nuclear clean-up sites. Furthermore, the studies focused on drinking water systems use non-radioactive surrogates. Non-radioactive cobalt was shown to be persistent on iron due to oxidation with free chlorine in drinking water and precipitation on the iron surface. Decontamination with acidification was an effective removal method. Strontium persistence on iron was transient in tap water, but adherence to cement-mortar has been demonstrated and should be further explored. Cesium persistence on iron water infrastructure was observed when flow was stagnant, but not with water flow present. Future research suggestions focus on expanding the available cesium, strontium and cobalt persistence data to other common infrastructure materials, specifically cement-mortar. Further exploration chelating agents and low pH treatment is recommended for future decontamination studies. Published by Elsevier Ltd.
C1 [Szabo, Jeff; Minamyer, Scott] US EPA, Natl Homeland Secur Res Ctr NG 16, Cincinnati, OH 45268 USA.
RP Szabo, J (reprint author), US EPA, Natl Homeland Secur Res Ctr NG 16, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM szabo.jeff@epa.gov
NR 38
TC 2
Z9 3
U1 7
U2 62
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2014
VL 72
SI SI
BP 129
EP 132
DI 10.1016/j.envint.2014.01.020
PG 4
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OB
UT WOS:000341470300016
PM 24529629
ER
PT J
AU Molina, M
Hunter, S
Cyterski, M
Peed, LA
Kelty, CA
Sivaganesan, M
Mooney, T
Prieto, L
Shanks, OC
AF Molina, Marirosa
Hunter, Shayla
Cyterski, Mike
Peed, Lindsay A.
Kelty, Catherine A.
Sivaganesan, Mano
Mooney, Thomas
Prieto, Lourdes
Shanks, Orin C.
TI Factors affecting the presence of human-associated and fecal indicator
real-time quantitative PCR genetic markers in urban-impacted
recreational beaches
SO WATER RESEARCH
LA English
DT Article
DE FIB; MST; Virtual Beach; Predictive modeling; Human contamination
ID 16S RIBOSOMAL-RNA; MICROBIAL SOURCE TRACKING; STORMWATER RUNOFF;
ENVIRONMENTAL WATERS; PREDICTIVE MODELS; POLLUTION; BACTEROIDES;
CONTAMINATION; BACTERIA; ASSAYS
AB Urban runoff can carry a variety of pollutants into recreational beaches, often including bacterial pathogens and indicators of fecal contamination. To develop complete recreational criteria and risk assessments, it is necessary to understand conditions under which human contamination could be present at beaches solely impacted by urban runoff. Accurately estimating risk requires understanding sources, concentrations, and transport mechanisms of microbial contaminants in these environments. By applying microbial source tracking methods and empirical modeling, we assessed the presence and level of human contamination at urban runoff impacted recreational beaches. We also identified environmental parameters and pollution sources that can influence the concentration and transport of culturable and molecular fecal indicator bacteria (FIB) in systems impacted solely by urban runoff. Water samples and physico-chemical parameters were collected from shoreline locations from three South Carolina (SC) beaches (five locations per beach) and two Florida (FL) beaches (three locations per beach). Each SC beach was directly impacted by swashes or tidal creeks receiving stormwater runoff from the urbanized area and therefore were designated as swash drain associated (SDA) beaches, while FL beaches were designated as non-swash drain associated (NSDA). Sampling in swash drains (SD; three sites per SD) directly impacting each SC beach was also conducted. Results indicate that although culturable (enterococci) and real-time quantitative polymerase chain reaction (qPCR) (EC235857, Entero1, and GenBac3) FIB concentrations were, on average, higher at SD locations, SDA beaches did not have consistently higher molecular FIB signals compared to NSDA beaches. Both human-associated markers (HF183 and HumM2) were concomitantly found only at SDA beaches. Bacteroidales species-specific qPCR markers (BsteriF1 and BuniF2) identified differences in the Bacteroidales community, depending on beach type. The marker for general Bacteroidales was most abundant at SD locations and exhibited a high correlation with both culturable and other molecular markers. Combining molecular information with predictive modeling allowed us to identify both alongshore movement of currents and SD outflow as significant influences on the concentration of molecular and culturable indicators in the bathing zone. Data also suggests that combining methodologies is a useful and cost effective approach to help understand transport dynamics of fecal contamination and identify potential sources of contamination at marine beaches. Published by Elsevier Ltd.
C1 [Molina, Marirosa; Cyterski, Mike; Prieto, Lourdes] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA USA.
[Hunter, Shayla] SSA Contractor USEPA, ORD, NERL, Athens, GA USA.
[Peed, Lindsay A.; Kelty, Catherine A.; Sivaganesan, Mano; Shanks, Orin C.] US EPA, ORD, Natl Risk Management Res Lab, Cincinnati, OH USA.
[Mooney, Thomas] SSA Contractor USEPA, ORD, NRMRL, Cincinnati, OH USA.
RP Molina, M (reprint author), 960 Coll Stn Rd, Athens, GA 30605 USA.
EM molina.marirosa@epa.gov
NR 46
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD NOV 1
PY 2014
VL 64
BP 196
EP 208
DI 10.1016/j.watres.2014.06.036
PG 13
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AO4YY
UT WOS:000341348500019
PM 25061692
ER
PT J
AU More, TT
Yadav, JSS
Yan, S
Tyagi, RD
Surampalli, RY
AF More, T. T.
Yadav, J. S. S.
Yan, S.
Tyagi, R. D.
Surampalli, R. Y.
TI Extracellular polymeric substances of bacteria and their potential
environmental applications
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Review
DE Bioflocculants; Bacterial polymers; Extracellular polymeric substances;
Wastewater; Sludge; Pollution control
ID WASTE-WATER TREATMENT; SOLUBLE MICROBIAL PRODUCTS; ACTIVATED-SLUDGE
FLOCS; PROTEUS-MIRABILIS TJ-1; BACILLUS-SUBTILIS; BIOFILM FORMATION;
BIOFLOCCULANT PRODUCTION; HEAVY-METALS; SOUTH-AFRICA; PART I
AB Biopolymers are considered a potential alternative to conventional chemical polymers because of their ease of biodegradability, high efficiency, non-toxicity and non-secondary pollution. Recently, extracellular polymeric substances (EPS, biopolymers produced by the microorganisms) have been recognised by many researchers as a potential flocculent for their applications in various water, wastewater and sludge treatment processes. In this context, literature information on EPS is widely dispersed and is very scarce. Thus, this review marginalizes various studies conducted so far about EPS nature-production-recovery, properties, environmental applications and moreover, critically examines future research needs and advanced application prospective of the EPS. One of the most important aspect of chemical composition and structural details of different moieties of EPS in terms of carbohydrates, proteins, extracellular DNA, lipid and surfactants and humic substances are described. These chemical characteristics of EPS in relation to formation and properties of microbial aggregates as well as degradation of EPS in the matrix (biomass, flocs etc) are analyzed. The important engineering properties (based on structural characteristics) such as adsorption, biodegradability, hydrophilicity/hydrophobicity of EPS matrix are also discussed in details. Different aspects of EPS production process such as bacterial strain maintenance; inoculum and factors affecting EPS production were presented. The important factors affecting EPS production include growth phase, carbon and nitrogen sources and their ratio, role of other nutrients (phosphorus, micronutrients/trace elements, and vitamins), impact of pH, temperature, metals, aerobic versus anaerobic conditions and pure and mixed culture. The production of EPS in high concentration with high productivity is essential due to economic reasons. Therefore, the knowledge about all the aspects of EPS production (listed above) is highly essential to formulate a logical and scientific basis for the research and industrial activities. One of the very important issues in the production/application/biodegradation of EPS is how the EPS is extracted from the matrix or a culture broth. Moreover, EPS matrix available in different forms (crude, loosely bound, tightly bound, slime, capsular and purified) can be used as a bioflocculant material. Several chemical and physical methods for the extraction of EPS (crude form or purified form) from different sources have been analyzed and reported. There is ample information available in the literature about various EPS extraction methods. Flocculability, dewaterability and biosorption ability are the very attractive engineering properties of the EPS matrix. Recent information on important aspects of these properties qualitatively as well as quantitatively has been described. Recent information on the mechanism of flocculation mediated by EPS is presented. Potential role of EPS in sludge dewatering and biosorption phenomenon has been discussed in details. Different factors influencing the EPS ability to flocculate and dewaterability of different suspensions have been included. The factors considered for the discussion are cations, different forms of EPS, concentration of EPS, protein and carbohydrate content of EPS, molecular weight of EPS, pH of the suspension, temperature etc. These factors were selected for the study based upon their role in the flocculation and dewatering mechanism as well the most recent available literature findings on these factors.
For example, only recently it has been demonstrated that there is an optimum EPS concentration for sludge flocculation/dewatering. High or low concentration of EPS can lead to destabilization of flocs. Role of EPS in environmental applications such as water treatment, wastewater flocculation and settling, colour removal from wastewater, sludge dewatering, metal removal and recovery, removal of toxic organic compounds, landfill leachate treatment, soil remediation and reclamation has been presented based on the most recent available information. However, data available on environmental application of EPS are very limited. Investigations are required for exploring the potential of field applications of EPS. Finally, the limitations in the knowledge gap are outlined and the research needs as well as future perspectives are highlighted. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [More, T. T.; Yadav, J. S. S.; Yan, S.; Tyagi, R. D.] Univ Quebec, Ctr Eau Terre & Environm, Inst Natl Rech Sci, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP More, TT (reprint author), Univ Quebec, Ctr Eau Terre & Environm, Inst Natl Rech Sci, 490 Couronne, Quebec City, PQ G1K 9A9, Canada.
EM more.tanaji@gmail.com; tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A 4984]
FX The authors are thankful to the Natural Sciences and Engineering
Research Council of Canada (Grant A 4984, Strategic Grant and Canada
Research Chair) for their financial support. The views and opinions
expressed in this article are those of the authors.
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U2 751
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD NOV 1
PY 2014
VL 144
BP 1
EP 25
DI 10.1016/j.jenvman.2014.05.010
PG 25
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AM6YL
UT WOS:000340011800001
PM 24907407
ER
PT J
AU Spero, TL
Otte, MJ
Bowden, JH
Nolte, CG
AF Spero, Tanya L.
Otte, Martin J.
Bowden, Jared H.
Nolte, Christopher G.
TI Improving the representation of clouds, radiation, and precipitation
using spectral nudging in the Weather Research and Forecasting model
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
DE regional climate modeling; spectral nudging; downscaling; WRF
ID REGIONAL CLIMATE MODEL; 4-DIMENSIONAL DATA ASSIMILATION; PART I;
SIMULATIONS; MOISTURE; REANALYSIS; TEMPERATURE; SENSITIVITY; HUMIDITY;
SYSTEM
AB Spectral nudginga scale-selective interior constraint techniqueis commonly used in regional climate models to maintain consistency with large-scale forcing while permitting mesoscale features to develop in the downscaled simulations. Several studies have demonstrated that spectral nudging improves the representation of regional climate in reanalysis-forced simulations compared with not using nudging in the interior of the domain. However, in the Weather Research and Forecasting (WRF) model, spectral nudging tends to produce degraded precipitation simulations when compared to analysis nudgingan interior constraint technique that is scale indiscriminate but also operates on moisture fields which until now could not be altered directly by spectral nudging. Since analysis nudging is less desirable for regional climate modeling because it dampens fine-scale variability, changes are proposed to the spectral nudging methodology to capitalize on differences between the nudging techniques and aim to improve the representation of clouds, radiation, and precipitation without compromising other fields. These changes include adding spectral nudging toward moisture, limiting nudging to below the tropopause, and increasing the nudging time scale for potential temperature, all of which collectively improve the representation of mean and extreme precipitation, 2 m temperature, clouds, and radiation, as demonstrated using a model-simulated 20 year historical period. Such improvements to WRF may increase the fidelity of regional climate data used to assess the potential impacts of climate change on human health and the environment and aid in climate change mitigation and adaptation studies.
C1 [Spero, Tanya L.; Otte, Martin J.; Nolte, Christopher G.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Bowden, Jared H.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA.
RP Spero, TL (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM spero.tanya@epa.gov
RI Nolte, Christopher/H-4345-2012;
OI Nolte, Christopher/0000-0001-5224-9965; Spero, Tanya/0000-0002-1600-0422
FU United States Environmental Protection Agency through its Office of
Research and Development
FX In accordance with the AGU's Data Policy, data and software used in this
paper will be made available upon request from the corresponding author.
The CERES data that were used in this paper are monthly 1 degrees x 1
degrees Terra MODIS Edition 2-D data, available from
https://eosweb.larc.nasa.gov/project/ceres/srbavg_table. The authors
thank James Godowitch, Kiran Alapaty, Rohit Mathur (U.S. EPA), and three
anonymous reviewers for constructive comments that served to strengthen
this paper. The United States Environmental Protection Agency through
its Office of Research and Development funded and managed the research
described here. It has been subjected to the Agency's administrative
review and approved for publication.
NR 45
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PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD OCT 27
PY 2014
VL 119
IS 20
BP 11682
EP 11694
DI 10.1002/2014JD022173
PG 13
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AU0FE
UT WOS:000345298100019
ER
PT J
AU Buskirk, AD
Green, BJ
Lemons, AR
Nayak, AP
Goldsmith, WT
Kashon, ML
Anderson, SE
Hettick, JM
Templeton, SP
Germolec, DR
Beezhold, DH
AF Buskirk, Amanda D.
Green, Brett J.
Lemons, Angela R.
Nayak, Ajay P.
Goldsmith, W. Travis
Kashon, Michael L.
Anderson, Stacey E.
Hettick, Justin M.
Templeton, Steven P.
Germolec, Dori R.
Beezhold, Donald H.
TI A Murine Inhalation Model to Characterize Pulmonary Exposure to Dry
Aspergillus fumigatus Conidia
SO PLOS ONE
LA English
DT Article
ID FUNGAL SPORES; C57BL/6 MICE; RESPONSES; ASTHMA; CELLS; MICROORGANISMS;
SENSITIZATION; GERMINATION; INFECTION; ALLERGENS
AB Most murine models of fungal exposure are based on the delivery of uncharacterized extracts or liquid conidia suspensions using aspiration or intranasal approaches. Studies that model exposure to dry fungal aerosols using whole body inhalation have only recently been described. In this study, we aimed to characterize pulmonary immune responses following repeated inhalation of conidia utilizing an acoustical generator to deliver dry fungal aerosols to mice housed in a nose only exposure chamber. Immunocompetent female BALB/cJ mice were exposed to conidia derived from Aspergillus fumigatus wild-type (WT) or a melanin-deficient (Delta alb1) strain. Conidia were aerosolized and delivered to mice at an estimated deposition dose of 1 x 10(5) twice a week for 4 weeks (8 total). Histopathological and immunological endpoints were assessed 4, 24, 48, and 72 hours after the final exposure. Histopathological analysis showed that conidia derived from both strains induced lung inflammation, especially at 24 and 48 hour time points. Immunological endpoints evaluated in bronchoalveolar lavage fluid (BALF) and the mediastinal lymph nodes showed that exposure to WT conidia led to elevated numbers of macrophages, granulocytes, and lymphocytes. Importantly, CD8(+) IL17(+) (Tc17) cells were significantly higher in BALF and positively correlated with germination of A. fumigatus WT spores. Germination was associated with specific IgG to intracellular proteins while Delta alb1 spores elicited antibodies to cell wall hydrophobin. These data suggest that inhalation exposures may provide a more representative analysis of immune responses following exposures to environmentally and occupationally prevalent fungal contaminants.
C1 [Buskirk, Amanda D.; Green, Brett J.; Lemons, Angela R.; Nayak, Ajay P.; Anderson, Stacey E.; Hettick, Justin M.; Templeton, Steven P.; Beezhold, Donald H.] NIOSH, Allergy & Clin Immunol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
[Goldsmith, W. Travis] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
[Kashon, Michael L.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
[Germolec, Dori R.] Natl Inst Environm Hlth Sci, Natl Toxicol Program Div, Toxicol Branch, Res Triangle Pk, NC USA.
RP Beezhold, DH (reprint author), NIOSH, Allergy & Clin Immunol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
EM zec1@cdc.gov
OI Lemons, Angela/0000-0003-3057-9888
FU intramural National Institute for Occupational Safety and Health
(NIOSH); NIEHS IAA [AES 12007-00100000]
FX This study was supported by intramural National Institute for
Occupational Safety and Health (NIOSH) funding and by an interagency
agreement with NIEHS IAA# AES 12007-00100000. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 23
PY 2014
VL 9
IS 10
AR e109855
DI 10.1371/journal.pone.0109855
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AR5ZY
UT WOS:000343662800019
PM 25340353
ER
PT J
AU Alavanja, MCR
Hofmann, JN
Lynch, CF
Hines, CJ
Barry, KH
Barker, J
Buckman, DW
Thomas, K
Sandler, DP
Hoppin, JA
Koutros, S
Andreotti, G
Lubin, JH
Blair, A
Freeman, LEB
AF Alavanja, Michael C. R.
Hofmann, Jonathan N.
Lynch, Charles F.
Hines, Cynthia J.
Barry, Kathryn H.
Barker, Joseph
Buckman, Dennis W.
Thomas, Kent
Sandler, Dale P.
Hoppin, Jane A.
Koutros, Stella
Andreotti, Gabriella
Lubin, Jay H.
Blair, Aaron
Freeman, Laura E. Beane
TI Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant se in
the Agricultural Health Study
SO PLOS ONE
LA English
DT Article
ID PESTICIDE EXPOSURE; OCCUPATIONAL-EXPOSURE; CANCER-RISK; ADIPOSE-TISSUE;
UNITED-STATES; FARMERS; ORGANOCHLORINES; APPLICATORS; LINDANE; COHORT
AB Farming and pesticide use have previously been linked to non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). We evaluated agricultural use of specific insecticides, fungicides, and fumigants and risk of NHL and NHL-subtypes (including CLL and MM) in a U.S.-based prospective cohort of farmers and commercial pesticide applicators. A total of 523 cases occurred among 54,306 pesticide applicators from enrollment (1993-97) through December 31, 2011 in Iowa, and December 31, 2010 in North Carolina. Information on pesticide use, other agricultural exposures and other factors was obtained from questionnaires at enrollment and at follow-up approximately five years later (1999-2005). Information from questionnaires, monitoring, and the literature were used to create lifetime-days and intensity-weighted lifetime days of pesticide use, taking into account exposure-modifying factors. Poisson and polytomous models were used to calculate relative risks (RR) and 95% confidence intervals (CI) to evaluate associations between 26 pesticides and NHL and five NHL-subtypes, while adjusting for potential confounding factors. For total NHL, statistically significant positive exposure-response trends were seen with lindane and DDT. Terbufos was associated with total NHL in ever/never comparisons only. In subtype analyses, terbufos and DDT were associated with small cell lymphoma/chronic lymphocytic leukemia/marginal cell lymphoma, lindane and diazinon with follicular lymphoma, and permethrin with MM. However, tests of homogeneity did not show significant differences in exposure-response among NHL-subtypes for any pesticide. Because 26 pesticides were evaluated for their association with NHL and its subtypes, some chance finding could have occurred. Our results showed pesticides from different chemical and functional classes were associated with an excess risk of NHL and NHL subtypes, but not all members of any single class of pesticides were associated with an elevated risk of NHL or NHL subtypes. These findings are among the first to suggest links between DDT, lindane, permethrin, diazinon and terbufos with NHL subtypes.
C1 [Alavanja, Michael C. R.; Hofmann, Jonathan N.; Barry, Kathryn H.; Koutros, Stella; Andreotti, Gabriella; Lubin, Jay H.; Blair, Aaron; Freeman, Laura E. Beane] NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
[Lynch, Charles F.] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA.
[Hines, Cynthia J.] NIOSH, Cincinnati, OH 45226 USA.
[Barker, Joseph; Buckman, Dennis W.] IMS Inc, Calverton, MD USA.
[Thomas, Kent] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Sandler, Dale P.; Hoppin, Jane A.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
RP Alavanja, MCR (reprint author), NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
EM alavanjm@mail.nih.gov
RI Beane Freeman, Laura/C-4468-2015
OI Beane Freeman, Laura/0000-0003-1294-4124
FU Intramural Research Program of the NIH, National Cancer Institute,
Division of Cancer Epidemiology and Genetics [Z01CP010119]; National
Institutes of Environmental Health Sciences [Z01ES049030]; IMS, Inc
FX This work was supported by the Intramural Research Program of the NIH,
National Cancer Institute, Division of Cancer Epidemiology and Genetics
(Z01CP010119) and The National Institutes of Environmental Health
Sciences (Z01ES049030). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript. IMS, Inc, provided support in the form of salaries for
authors Joseph Barker and Denis W Buckman, but did not have any
additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The specific
roles of these authors are articulated in the 'author contributions'
section.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 22
PY 2014
VL 9
IS 10
AR e109332
DI 10.1371/journal.pone.0109332
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AR6DY
UT WOS:000343674800010
PM 25337994
ER
PT J
AU Reichman, JR
Vize, PD
AF Reichman, Jay R.
Vize, Peter D.
TI Separate Introns Gained within Short and Long Soluble
Peridinin-Chlorophyll a-Protein Genes during Radiation of Symbiodinium
(Dinophyceae) Clade A and B Lineages
SO PLOS ONE
LA English
DT Article
ID SYMBIOTIC DINOFLAGELLATE SYMBIODINIUM; MAXIMUM-LIKELIHOOD APPROACH;
CORAL-ALGAL SYMBIOSIS; CRYPTIC SPLICE SITES; GENUS SYMBIODINIUM;
GYMNODINIUM MICROADRIATICUM; AMPHIDINIUM-CARTERAE; MARINE-INVERTEBRATES;
BINDING-PROTEIN; DNA-SEQUENCES
AB Here we document introns in two Symbiodinium clades that were most likely gained following divergence of this genus from other peridinin-containing dinoflagellate lineages. Soluble peridinin-chlorophyll a-proteins (sPCP) occur in short and long forms in different species. Duplication and fusion of short sPCP genes produced long sPCP genes. All short and long sPCP genes characterized to date, including those from free living species and Symbiodinium sp. 203 (clade C/type C2) are intronless. However, we observed that long sPCP genes from two Caribbean Symbiodinium clade B isolates each contained two introns. To test the hypothesis that introns were gained during radiation of clade B, we compared sPCP genomic and cDNA sequences from 13 additional distinct Caribbean and Pacific Symbiodinium clade A, B, and F isolates. Long sPCP genes from all clade B/B1 and B/B19 descendants contain orthologs of both introns. Short sPCP genes from S. pilosum (A/A2) and S. muscatinei (B/B4) plus long sPCP genes from S. microadriaticum (A/A1) and S. kawagutii (F/F1) are intronless. Short sPCP genes of S. microadriaticum have a third unique intron. Symbiodinium clade B long sPCP sequences are useful for assessing divergence among B1 and B19 descendants. Phylogenetic analyses of coding sequences from four dinoflagellate orders indicate that introns were gained independently during radiation of Symbiodinium clades A and B. Long sPCP introns were present in the most recent common ancestor of Symbiodinium clade B core types B1 and B19, which apparently diverged sometime during the Miocene. The clade A short sPCP intron was either gained by S. microadriaticum or possibly by the ancestor of Symbiodinium types A/A1, A3, A4 and A5. The timing of short sPCP intron gain in Symbiodinium clade A is less certain. But, all sPCP introns were gained after fusion of ancestral short sPCP genes, which we confirm as occurring once in dinoflagellate evolution.
C1 [Reichman, Jay R.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
[Reichman, Jay R.] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA.
[Vize, Peter D.] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada.
RP Reichman, JR (reprint author), US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
EM reichman.jay@epa.gov
FU National Undersea Research Program Caribbean Marine Research Center -
Project Development Grant [CMRC-97-7106]; Oregon State University
Agricultural Research Foundation-Molecular Evolution of Endosymbiotic
Marine Microalgae Project; Natural Sciences and Engineering Research
Council of Canada - Discovery Award
FX This work was supported by the National Undersea Research Program
Caribbean Marine Research Center - Project Development Grant
CMRC-97-7106 to JRR (http://www.perryinstitute.org/research); and by the
Oregon State University Agricultural Research Foundation-Molecular
Evolution of Endosymbiotic Marine Microalgae Project donation to JRR
(http://agresearchfoundation.oregonstate.edu). This work was also
supported by the Natural Sciences and Engineering Research Council of
Canada - Discovery Award to PDV
(http://www.nserc-crsng.gc.ca/index_eng.asp). The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 98
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U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 17
PY 2014
VL 9
IS 10
AR e110608
DI 10.1371/journal.pone.0110608
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AT8TF
UT WOS:000345204100094
PM 25330037
ER
PT J
AU Wade, TJ
Lin, CJ
Jagai, JS
Hilborn, ED
AF Wade, Timothy J.
Lin, Cynthia J.
Jagai, Jyotsna S.
Hilborn, Elizabeth D.
TI Flooding and Emergency Room Visits for Gastrointestinal Illness in
Massachusetts: A Case-Crossover Study
SO PLOS ONE
LA English
DT Article
ID UNITED-STATES; RISK; EVENTS; DESIGN; HEALTH; STRATEGIES; OUTBREAKS;
EXPOSURE; ENGLAND; DISEASE
AB Introduction: Floods and other severe weather events are anticipated to increase as a result of global climate change. Floods can lead to outbreaks of gastroenteritis and other infectious diseases due to disruption of sewage and water infrastructure and impacts on sanitation and hygiene. Floods have also been indirectly associated with outbreaks through population displacement and crowding.
Methods: We conducted a case-crossover study to investigate the association between flooding and emergency room visits for gastrointestinal illness (ER-GI) in Massachusetts for the years 2003 through 2007. We obtained ER-GI visits from the State of Massachusetts and records of floods from the National Oceanic and Atmospheric Association's Storm Events Database. ER-GI visits were considered exposed if a flood occurred in the town of residence within three hazard periods of the visit: 04 days; 5-9 days; and 10-14 days. A time-stratified bi-directional design was used for control selection, matching on day of the week with two weeks lead or lag time from the ER-GI visit. Fixed effect logistic regression models were used to estimate the risk of ER-GI visits following the flood.
Results and Conclusions: A total of 270,457 ER-GI visits and 129 floods occurred in Massachusetts over the study period. Across all counties, flooding was associated with an increased risk for ER-GI in the 0-4 day period after flooding (Odds Ratio: 1.08; 95% Confidence Interval: 1.03-1.12); but not the 5-9 days (Odds Ratio: 0.995; 95% Confidence Interval: 0.955-1.04) or the 10-14 days after (Odds Ratio: 0.966, 95% Confidence Interval: 0.927-1.01). Similar results were observed for different definitions of ER-GI. The effect differed across counties, suggesting local differences in the risk and impact of flooding. Statewide, across the study period, an estimated 7% of ER-GI visits in the 0-4 days after a flood event were attributable to flooding.
C1 [Wade, Timothy J.; Hilborn, Elizabeth D.] United States Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27514 USA.
[Lin, Cynthia J.] United States Environm Protect Agcy, ORISE, Res Participat Program, Chapel Hill, NC USA.
[Lin, Cynthia J.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Jagai, Jyotsna S.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA.
RP Wade, TJ (reprint author), United States Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27514 USA.
EM wade.tim@epa.gov
FU United States Environmental Protection Agency
FX This work was funded by the United States Environmental Protection
Agency. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 17
PY 2014
VL 9
IS 10
AR e110474
DI 10.1371/journal.pone.0110474
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AT8TF
UT WOS:000345204100079
PM 25329916
ER
PT J
AU Kurhanewicz, N
McIntosh-Kastrinsky, R
Tong, HY
Walsh, L
Farraj, AK
Hazari, MS
AF Kurhanewicz, Nicole
McIntosh-Kastrinsky, Rachel
Tong, Haiyan
Walsh, Leon
Farraj, Aimen K.
Hazari, Mehdi S.
TI Ozone co-exposure modifies cardiac responses to fine and ultrafine
ambient particulate matter in mice: concordance of electrocardiogram and
mechanical responses
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
DE Air pollution; Cardiac function; Ventricular contraction;
Electrocardiogram; Arrhythmia; Particulate matter
ID HEART-RATE-VARIABILITY; DIESEL-EXHAUST INHALATION; AIR-POLLUTION;
HYPERTENSIVE-RATS; HEALTHY-VOLUNTEERS; BLOOD-PRESSURE; EXPOSURE;
PARTICLES; LUNG; PULMONARY
AB Background: Studies have shown a relationship between air pollution and increased risk of cardiovascular morbidity and mortality. Due to the complexity of ambient air pollution composition, recent studies have examined the effects of co-exposure, particularly particulate matter (PM) and gas, to determine whether pollutant interactions alter (e.g. synergistically, antagonistically) the health response. This study examines the independent effects of fine (FCAPs) and ultrafine (UFCAPs) concentrated ambient particles on cardiac function, and determine the impact of ozone (O-3) co-exposure on the response. We hypothesized that UFCAPs would cause greater decrement in mechanical function and electrical dysfunction than FCAPs, and that O-3 co-exposure would enhance the effects of both particle-types.
Methods: Conscious/unrestrained radiotelemetered mice were exposed once whole-body to either 190 mu g/m(3) FCAPs or 140 mu g/m(3) UFCAPs with/without 0.3 ppm O-3; separate groups were exposed to either filtered air (FA) or O-3 alone. Heart rate (HR) and electrocardiogram (ECG) were recorded continuously before, during and after exposure, and cardiac mechanical function was assessed using a Langendorff perfusion preparation 24 hrs post-exposure.
Results: FCAPs alone caused a significant decrease in baseline left ventricular developed pressure (LVDP) and contractility, whereas UFCAPs did not; neither FCAPs nor UFCAPs alone caused any ECG changes. O-3 co-exposure with FCAPs caused a significant decrease in heart rate variability when compared to FA but also blocked the decrement in cardiac function. On the other hand, O-3 co-exposure with UFCAPs significantly increased QRS-interval, QTc and non-conducted P-wave arrhythmias, and decreased LVDP, rate of contractility and relaxation when compared to controls.
Conclusions: These data suggest that particle size and gaseous interactions may play a role in cardiac function decrements one day after exposure. Although FCAPs + O-3 only altered autonomic balance, UFCAPs + O-3 appeared to be more serious by increasing cardiac arrhythmias and causing mechanical decrements. As such, O-3 appears to interact differently with FCAPs and UFCAPs, resulting in varied cardiac changes, which suggests that the cardiovascular effects of particle-gas co-exposures are not simply additive or even generalizable. Additionally, the mode of toxicity underlying this effect may be subtle given none of the exposures described here impaired post-ischemia recovery.
C1 [Kurhanewicz, Nicole] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[McIntosh-Kastrinsky, Rachel] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Tong, Haiyan; Walsh, Leon; Farraj, Aimen K.; Hazari, Mehdi S.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27711 USA.
RP Kurhanewicz, N (reprint author), Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
EM nak@email.unc.edu; ramcinto@email.unc.edu; hazari.mehdi@epa.gov
FU EPA-UNC [CR 83515201]; CEMALB [CR 83346301]; EPA [CR 83346301]
FX EPA-UNC Toxicology Training Agreement (CR 83515201) for NK and CEMALB
cooperative agreement with EPA (CR 83346301 - Health Effects of
Environmental Pollutants in Humans) for RMK.
NR 67
TC 6
Z9 6
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD OCT 16
PY 2014
VL 11
AR 54
DI 10.1186/s12989-014-0054-4
PG 16
WC Toxicology
SC Toxicology
GA AU8UO
UT WOS:000345872000001
PM 25318591
ER
PT J
AU Albert, RJ
McLaughlin, C
Falatko, D
AF Albert, Ryan J.
McLaughlin, Christine
Falatko, Debra
TI Characterization of fish hold effluent discharged from commercial
fishing vessels into harbor waters
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE Fishing vessel; Water quality; Biochemical Oxygen Demand; Vessel
discharges; Incidental discharges; Fish hold
ID LIFE-CYCLE ASSESSMENT; ENVIRONMENTAL IMPACTS; UNITED-KINGDOM;
FRESH-WATER; FISHERIES; MARINE; COPPER; ESTUARINE; COASTAL; CONSERVATION
AB Fish hold effluent and the effluent produced from the cleaning of fish holds may contain organic material resulting from the degradation of seafood and cleaning products (e.g., soaps and detergents). This effluent is often discharged by vessels into near shore waters and, therefore, could have the potential to contribute to water pollution in bays and estuaries. We characterized effluent from commercial fishing vessels with holds containing refrigerated seawater, ice slurry, or chipped ice. Concentrations of trace heavy metals, wet chemistry parameters, and nutrients in effluent were compared to screening benchmarks to determine if there is a reasonable potential for effluent discharge to contribute to nonattainment of water quality standards. Most analytes (67%) exceeded their benchmark concentration and, therefore, may have the potential to pose risk to human health or the environment if discharges are in significant quantities or there are many vessels discharging in the same areas. Published by Elsevier Ltd.
C1 [Albert, Ryan J.; McLaughlin, Christine] US EPA, Off Water, Off Wastewater Management, Permits Div, Washington, DC 20460 USA.
[Falatko, Debra] Eastern Res Grp Inc, Chantilly, VA 20151 USA.
RP Albert, RJ (reprint author), US EPA, Off Water, Off Wastewater Management, Permits Div, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM albert.ryan@epa.gov
FU U.S. Department of Energy; EPA
FX We would like to thank Ron Altman, John Bourbon, Cindy Caporale, Robin
Costas, John Curry, Jim Dorsey, Norman Fritsche, Jamie Hale, Maria
Javier, Deborah Kay, John Lee, Renee Lettieri, Kevin Martin, Kevin Poff,
William Ricket, Dave Russel, Sue Warner, and Larry Zintec in EPA's
Regional laboratories for facilitating and conducting the laboratory
analyses of all samples collected for this study. Mark Briggs and
Kathleen Wu of Eastern Research Group, Inc. and Robin Danesi, Cindi
Godsey, and Marcus Zobrist of EPA assisted in vessel sampling, sampling
logistics, and provided other assistance throughout study
implementation. Tyler Linton, Doug Endicott, and Michelle Moore of the
Great Lakes Environmental Center assisted in data entry and handling and
provided other support during the course of the sampling and study
design. Finally, we would like to thank Bob Bastian and Brian Rappoli
for their feedback on the manuscript. The opinions expressed are the
authors alone and do not necessarily reflect the opinions of the U.S.
Environmental Protection Agency. This project was supported in part by
an appointment to the Internship/Research Participation Program at the
Office of Wastewater Management, U.S. Environmental Protection Agency,
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and EPA.
NR 51
TC 0
Z9 0
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD OCT 15
PY 2014
VL 87
IS 1-2
BP 29
EP 38
DI 10.1016/j.marpolbul.2014.08.015
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AS0ET
UT WOS:000343951800020
PM 25176279
ER
PT J
AU Schlosser, PM
Sasso, AF
AF Schlosser, Paul M.
Sasso, Alan F.
TI A revised model of ex-vivo reduction of hexavalent chromium in human and
rodent gastric juices
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Hexavalent chromium; Reduction; Gastric juice; Mouse; Rat; Human
ID PHARMACOKINETIC MODEL; DRINKING-WATER; ABSORPTION; RATS; TRIVALENT
AB Chronic oral exposure to hexavalent chromium (Cr-VI) in drinking water has been shown to induce tumors in the mouse gastrointestinal (GI) tract and rat oral cavity. The same is not true for trivalent chromium (Cr-III). Thus reduction of Cr-VI to Cr-III in gastric juices is considered a protective mechanism, and it has been suggested that the difference between the rate of reduction among mice, rats, and humans could explain or predict differences in sensitivity to Cr-VI. We evaluated previously published models of gastric reduction and believe that they do not fully describe the data on reduction as a function of Cr-VI concentration, time, and (in humans) pH. The previous models are parsimonious in assuming only a single reducing agent in rodents and describing pH-dependence using a simple function. We present a revised model that assumes three pools of reducing agents in rats and mice with pH-dependence based on known speciation chemistry. While the revised model uses more fitted parameters than the original model, they are adequately identifiable given the available data, and the fit of the revised model to the full range of data is shown to be significantly improved. Hence the revised model should provide better predictions of Cr-VI reduction when integrated into a corresponding PBPK model. Published by Elsevier Inc.
C1 [Schlosser, Paul M.; Sasso, Alan F.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Schlosser, PM (reprint author), US EPA, MD B243-01, Res Triangle Pk, NC 27711 USA.
EM schlosser.paul@epa.gov
NR 13
TC 4
Z9 4
U1 1
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD OCT 15
PY 2014
VL 280
IS 2
BP 352
EP 361
DI 10.1016/j.taap.2014.08.010
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA AS7OI
UT WOS:000344444700017
PM 25151221
ER
PT J
AU Yang, Z
Huang, YC
Kozie, H
de Crom, R
Ruetten, H
Wohlfart, P
Thomsen, RW
Kahlert, JA
Sorensen, HT
Jozefowski, S
Colby, A
Kobzik, L
AF Yang, Z.
Huang, Y-C.
Kozie, H.
de Crom, R.
Ruetten, H.
Wohlfart, P.
Thomsen, R. W.
Kahlert, J. A.
Sorensen, H. T.
Jozefowski, S.
Colby, A.
Kobzik, L.
TI Female Resistance to Pneumonia Identifies Lung Macrophage Nitric Oxide
Synthase-3 as a Therapeutic Target
SO ELIFE
LA English
DT Article
ID COMMUNITY-ACQUIRED PNEUMONIA; ALVEOLAR MACROPHAGE; REACTIVE OXYGEN;
PNEUMOCOCCAL PNEUMONIA; MICROBIAL PATHOGENS; MALE GENDER; MICE;
INFECTION; RECEPTOR; RISK
AB To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation and better survival. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. Inhibitors and genetically altered mice identify a critical role for estrogen-mediated activation of lung macrophage nitric oxide synthase-3 (NOS3). Epidemiologic data show decreased hospitalization for pneumonia in women receiving estrogen or statins (known to activate NOS3). Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance and increased host survival in both primary and secondary (post-influenza) pneumonia. The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza.
C1 [Yang, Z.; Colby, A.; Kobzik, L.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Huang, Y-C.] US EPA, Natl Hlth & Environm Effects Res Lab, Human Studies Div, Chapel Hill, NC USA.
[Kozie, H.] Beth Israel Deaconess Med Ctr, Crit Care & Sleep Med, Div Pulm, Boston, MA 02215 USA.
[de Crom, R.] Erasmus Univ, Med Ctr, Dept Cell Biol & Genet, Rotterdam, Netherlands.
[Ruetten, H.; Wohlfart, P.] Sanofi R&D Diabet Div, Frankfurt, Germany.
[Thomsen, R. W.; Kahlert, J. A.; Sorensen, H. T.] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
[Jozefowski, S.] Jagiellonian Univ, Coll Med, Dept Immunol, Krakow, Poland.
[Kobzik, L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.
RP Kobzik, L (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
EM lkobzik@hsph.harvard.edu
OI Thomsen, Reimar/0000-0001-9135-3474
NR 47
TC 9
Z9 9
U1 0
U2 0
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD OCT 15
PY 2014
VL 3
AR e03711
DI 10.7554/eLife.03711
PG 33
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AR2MR
UT WOS:000343422100002
ER
PT J
AU Campanha, HM
Carvalho, F
Schlosser, PM
AF Campanha, Helen M.
Carvalho, Felix
Schlosser, Paul M.
TI Active and peripheral anionic sites of acetylcholinesterase have
differential modulation effects on cell proliferation, adhesion and
neuritogenesis in the NG108-15 cell line
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Acetylcholinesterase; Peripheral anionic site; Acylation site; Cell
adhesion; Proliferation; Neuritogenesis
ID TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE; CHLORPYRIFOS-OXON; NEURITE
GROWTH; THIOFLAVIN-T; IN-VITRO; CHOLINESTERASE EXPRESSION; ACYLATION
SITE; NEUROTOXICITY; PROTEINS; ACTIVATION
AB The classical enzymatic role of acetylcholinesterase (AChE) is to terminate impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine (ACh). Inactivation of this enzyme's catalytic site is the primary mechanism of acute toxicity of OP insecticides (e.g. parathion, chlorpyrifos). There is now sufficient evidence to suggest that AChE has a neurotrophic function that may be altered by organophosphate (OP) exposure, resulting in defects of neuronal growth and development, though the clarification of the mechanisms involved require further in vitro investigation. In the present study, the mouse neuroblastoma x rat glioma hybrid NG108-15 cell line was used to investigate the differential effects between inhibition of the catalytic site and peripheral anionic site (PAS) of acetylcholinesterase (AChE) on cell adhesion, proliferation and neuritogenesis, in the presence and absence of human red blood cell (hRBC) AChE (ED3.1.1.7). AChE active-site inhibitor paraoxon (PO; 0.1-1.0 mu M), when added to NG108-15 cells grown on AChE-coated plates, had no effect on cell proliferation, but exerted a significant reduction in strongly adherent viable cells accompanied by mostly short process formations, with 18% of cells considered to be neuritogenic, similar to that observed on uncoated plates. In contrast, PO had no significant effect on cell adhesion and proliferation of NG108-15 cells on uncoated plates. The PAS-ligand thioflavin-T (Th-T; 0.5-25 mu M), however, decreased cell adhesion and proliferation, on both uncoated and ACh-E coated plates, with less magnitude on AChE-coated plates. Taken together, these results suggest that strong cell adherence and neuritogenesis are sensitive to PO in this cell culture model, with no impact on proliferation, in the presence of membrane bound AChE-coating, while there is no sensitivity to PO on uncoated plates. On the other hand, binding of Th-T directly to the PAS affects both cell adherence and proliferation, with less magnitude in the presence of membrane-bound AChE. The current study indicates that PO is deleterious in neural development during critical periods of strong cell adhesion and differentiation, interfering with AChE trophic function. Published by Elsevier Ireland Ltd.
C1 [Campanha, Helen M.] Rutgers State Univ, New Jersey Med Sch, Grad Sch Biomed Sci, Newark, NJ 07103 USA.
[Carvalho, Felix] Univ Porto, Fac Pharm, Dept Biol Sci, REQUIMTE,Lab Toxicol, P-4050313 Oporto, Portugal.
[Schlosser, Paul M.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Campanha, HM (reprint author), 16 Hughes Pl, Summit, NJ 07901 USA.
EM hcampanha@ymail.com
RI Carvalho, Felix/D-4914-2013
OI Carvalho, Felix/0000-0003-3858-3494
FU Rutgers; New Jersey Medical School-Graduate School of Biomedical
Sciences; Laboratory of Edward Flynn
FX We thank Kommarkur Hognason, Andrew P. Thomas, William Taggart, and
Kevin O'Driscoll for suggestions and critique. We thank Kommarkur
Hognason for assisting with the neuronal measurements. Financial support
was provided by the Rutgers, New Jersey Medical School-Graduate School
of Biomedical Sciences, Laboratory of Edward Flynn.
NR 43
TC 2
Z9 4
U1 2
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD OCT 15
PY 2014
VL 230
IS 2
BP 122
EP 131
DI 10.1016/j.toxlet.2014.03.012
PG 10
WC Toxicology
SC Toxicology
GA AP2CV
UT WOS:000341881000004
PM 24680925
ER
PT J
AU Corsini, E
Luebke, RW
Germolec, DR
DeWitt, JC
AF Corsini, Emanuela
Luebke, Robert W.
Germolec, Dori R.
DeWitt, Jamie C.
TI Perfluorinated compounds: Emerging POPs with potential immunotoxicity
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Perfluorinated compounds; Immunosuppression; PPAR-alpha receptor;
Cytokine; Vaccination
ID ACTIVATED RECEPTOR-ALPHA; PERFLUOROOCTANOIC ACID PFOA; B P65 SUBUNIT;
PEROXISOME PROLIFERATOR; AMMONIUM PERFLUOROOCTANOATE; HUMORAL IMMUNITY;
POLYFLUOROALKYL COMPOUNDS; PRENATAL EXPOSURE; DIETARY EXPOSURE;
PRODUCTION PLANT
AB Perfluorinated compounds (PFCs) have been recognized as an important class of environmental contaminants commonly detected in blood samples of both wildlife and humans. These compounds have been in use for more than 60 years as surface treatment chemicals, polymerization aids, and surfactants. They possess a strong carbon-fluorine bond, which leads to their environmental persistence. There is evidence from both epidemiology and laboratory studies that PFCs may be immunotoxic, affecting both cell-mediated and humoral immunity. Reported effects of PFCs include decreased spleen and thymus weights and cellularity, reduced specific antibody production, reduced survival after influenza infection, and altered cytokine production. Immunosuppression is a critical effect associated with exposure to PFCs, as it has been reported to reduce antibody responses to vaccination in children. Mounting evidence suggests that immunotoxicity in experimental animals can occur at serum concentrations below, within, or just above the reported range for highly exposed humans and wildlife. Considering bioaccumulation and exposure to multiple PFCs, the risk of immunotoxicity for humans and wildlife cannot be discounted. This review will discuss current and recently published work exploring the immunomodulatory effects of PFCs in experimental animals and humans. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Corsini, Emanuela] Univ Milan, Toxicol Lab, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy.
[Luebke, Robert W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Germolec, Dori R.] NIEHS, Natl Toxicol Program, NIH, Res Triangle Pk, NC USA.
[DeWitt, Jamie C.] E Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, Greenville, NC USA.
RP Corsini, E (reprint author), Univ Milan, Toxicol Lab, DiSFeB, Via Balzaretti 9, I-20133 Milan, Italy.
EM emanuela.corsini@unimi.it
OI DeWitt, Jamie/0000-0002-0440-4059
FU Intramural NIH HHS [Z99 ES999999]
NR 81
TC 22
Z9 25
U1 9
U2 72
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD OCT 15
PY 2014
VL 230
IS 2
BP 263
EP 270
DI 10.1016/j.toxlet.2014.01.038
PG 8
WC Toxicology
SC Toxicology
GA AP2CV
UT WOS:000341881000019
PM 24503008
ER
PT J
AU He, XX
de la Cruz, AA
O'Shea, KE
Dionysiou, DD
AF He, Xuexiang
de la Cruz, Armah A.
O'Shea, Kevin E.
Dionysiou, Dionysios D.
TI Kinetics and mechanisms of cylindrospermopsin destruction by sulfate
radical-based advanced oxidation processes
SO WATER RESEARCH
LA English
DT Article
DE Cylindrospermopsin; UV-254 nm; Persulfate; Advanced oxidation processes
(AOPs); Sulfate radical; Mechanism
ID CYANOBACTERIAL TOXIN CYLINDROSPERMOPSIN; HYDROGEN ABSTRACTION REACTIONS;
ELECTRON-SPIN RESONANCE; PULSE-RADIOLYSIS; AQUEOUS-SOLUTION; RATE
CONSTANTS; ORGANIC-MATTER; MICROCYSTIN-LR; POTASSIUM PEROXODISULFATE;
ACTIVATED PERSULFATE
AB Cylindrospermopsin (CYN) is a potent cyanobacterial toxin frequently found in water bodies worldwide raising concerns over the safety of drinking and recreational waters. A number of technologies have been investigated to remove and/or degrade cyanotoxins with advanced oxidation processes (AOPs) being among the most promising and effective for water detoxification. In this study, the degradation of CYN by sulfate radical-based UV-254 nm-AOPs was evaluated. The LTV/S2O82- (UV/peroxydisulfate) was more efficient than UV/HSO5- (UV/peroxysulfate) and UV/H2O2 (UV/hydrogen peroxide) processes when natural water samples were used as reaction matrices. The observed UV fluence based pseudo-first-order rate constants followed the expected order of radical quantum yields. The presence of 200 mu M natural organic matter (NOM) as carbon slightly inhibited the destruction of CYN; 1.24 mg L-1 NO3- (nitrate) had no significant influence on the removal efficiency and 50 mu g L-1 Fe2+ [iron (2+)] or Cu2+ [copper (2+)] improved the performance of LTV/S2O82-. The addition of tert-butyl alcohol (t-BuOH; hydroxyl radical scavenger) in the reaction yielded byproducts that indicated specific sites in CYN preferentially attacked by sulfate radicals (SRs). The predominant CYN degradation byproduct was P-448 consistent with fragmentation of the C5=C6 bond of the uracil ring. The subsequent formation of P-420 and P-392 through a stepwise loss of carbonyl group(s) further supported the fragmentation pathway at C5=C6. The byproduct P-432 was identified exclusively as mono-hydroxylation of CYN at tricyclic guanidine ring, whereas P-414 was detected as dehydrogenation at the tricyclic ring. The elimination of sulfate group and the opening of tricyclic ring were also observed. The possible degradation pathways of CYN by SR-AOP were presented. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [He, Xuexiang; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[O'Shea, Kevin E.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
[He, Xuexiang; Dionysiou, Dionysios D.] Univ Cyprus, NIREAS Int Water Res Ctr, Nicosia, Cyprus.
RP Dionysiou, DD (reprint author), Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
EM dionysios.d.dionysiou@uc.edu
RI He, Xuexiang/D-7564-2017
FU Cyprus Research Promotion Foundation; Republic of Cyprus; European
Regional Development Fund of the EU [NEA IPODOMI/STRATH/0308/09];
University Research Council of University of Cincinnati; Graduate School
of UC
FX This work was funded by the Cyprus Research Promotion Foundation through
Desmi 2009-2010 which is co-funded by the Republic of Cyprus and the
European Regional Development Fund of the EU under contract number NEA
IPODOMI/STRATH/0308/09. X. H. is grateful for the University Research
Council of University of Cincinnati for a Summer Research Fellowship and
Graduate School of UC for a Dissertation Completion Fellowship. D. D. D.
acknowledges support from the University of Cincinnati through a UNESCO
co-Chair Professor position on "Water Access and Sustainability". We are
thankful to Greater Cincinnati Water Works for providing water samples.
Disclaimer: The views expressed in this manuscript do not reflect the
views and policies of the US Environmental Protection Agency. Mention of
trade names or commercial products does not constitute endorsement.
NR 67
TC 32
Z9 33
U1 23
U2 200
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD OCT 15
PY 2014
VL 63
BP 168
EP 178
DI 10.1016/j.watres.2014.06.004
PG 11
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AO0IB
UT WOS:000340991200017
PM 25000199
ER
PT J
AU Beaulieu, JJ
Smolenski, RL
Nietch, CT
Townsend-Small, A
Elovitz, MS
AF Beaulieu, Jake J.
Smolenski, Rebecca L.
Nietch, Christopher T.
Townsend-Small, Amy
Elovitz, Michael S.
TI High Methane Emissions from a Midlatitude Reservoir Draining an
Agricultural Watershed
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ORGANIC-MATTER; LAKE; CARBON; SEDIMENT; FLUX; OXIDATION; SURFACES;
OXYGEN; RATES; DAMS
AB Reservoirs are a globally significant source of methane (CH4), although most measurements have been made in tropical and boreal systems draining undeveloped watersheds. To assess the magnitude of CH4 emissions from reservoirs in midlatitude agricultural regions, we measured CH4 and carbon dioxide (CO2) emission rates from William H. Harsha Lake (Ohio, U.S.A.), an agricultural impacted reservoir, over a 13 month period. The reservoir was a strong source of CH4 throughout the year, emitting on average 176 +/- 36 mg C m(-2) d(-1), the highest reservoir CH4 emissions profile documented in the United States to date. Contrary to our initial hypothesis, the largest CH4 emissions were during summer stratified conditions, not during fall turnover. The river-reservoir transition zone emitted CH4 at rates an order of magnitude higher than the rest of the reservoir, and total carbon emissions (i.e., CH4 + CO2) were also greater at the transition zone, indicating that the river delta supported greater carbon mineralization rates than elsewhere. Midlatitude agricultural impacted reservoirs may be a larger source of CH4 to the atmosphere than currently recognized, particularly if river deltas are consistent CH4 hot spots. We estimate that CH4 emissions from agricultural reservoirs could be a significant component of anthropogenic CH4 emissions in the U.S.A.
C1 [Beaulieu, Jake J.; Smolenski, Rebecca L.; Nietch, Christopher T.; Elovitz, Michael S.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Smolenski, Rebecca L.; Townsend-Small, Amy] Univ Cincinnati, Dept Geol, Cincinnati, OH 45221 USA.
[Townsend-Small, Amy] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
RP Beaulieu, JJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM beaulieu.jake@epa.gov
FU U.S. Environmental Protection Agency, through its Office of Research and
Development
FX We thank Jade Young and Jim O'Boyle of the U.S. Army Corp of Engineers
for logistical support. We also thank Kit Daniels, Dana Macke, Eric
Kleiner, and Don Brown for field and lab assistance. The U.S.
Environmental Protection Agency, through its Office of Research and
Development funded and managed this research. It has been subjected to
the Agency's administrative review and has been approved for external
publication. Any opinions expressed in this paper are those of the
authors and do not necessarily reflect the views of the Agency,
therefore, no official endorsement should be inferred. Any mention of
trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 41
TC 12
Z9 12
U1 4
U2 54
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 7
PY 2014
VL 48
IS 19
BP 11100
EP 11108
DI 10.1021/es501871g
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AQ7RJ
UT WOS:000343016600013
PM 25158047
ER
PT J
AU Green, HC
White, KM
Kelty, CA
Shanks, OC
AF Green, Hyatt C.
White, Karen M.
Kelty, Cathy A.
Shanks, Orin C.
TI Development of Rapid Canine Fecal Source Identification PCR-Based Assays
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; ESCHERICHIA-COLI; DNA HYBRIDIZATION;
GENETIC-MARKERS; DOGS; BACTEROIDALES; COMMUNITY; HUMANS; QPCR;
METAGENOMES
AB The extent to which dogs contribute to aquatic fecal contamination is unknown despite the potential for zoonotic transfer of harmful human pathogens. We used genome fragment enrichment (GFE) to identify novel nonribosomal microbial genetic markers potentially useful for detecting dog fecal contamination with PCR-based methods in environmental samples. Of the 679 sequences obtained from GFE, we used 84 for the development of PCR assays targeting putative canine-associated genetic markers. Twelve genetic markers were shown to be prevent among dog fecal samples and were rarely found in other animals. Three assays, DG3, DG37, and DG72, performed best in terms of specificity and sensitivity and were used for the development of SYBR Green and TaqMan quantitative PCR (qPCR) assays qPCR analysis of 244 fecal samples collected from a wide geographic range indicated that marker concentrations were below limits of detection in noncanine hosts. As a proof-of-concept, these markers were detected in urban stormwater samples, suggesting a future application of newly developed methods for water quality monitoring.
C1 [Green, Hyatt C.; White, Karen M.; Kelty, Cathy A.; Shanks, Orin C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Shanks, OC (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM shanks.orin@epa.gov
NR 42
TC 4
Z9 5
U1 5
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 7
PY 2014
VL 48
IS 19
BP 11453
EP 11461
DI 10.1021/es502637b
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AQ7RJ
UT WOS:000343016600055
PM 25203917
ER
PT J
AU Juhasz, AL
Smith, E
Nelson, C
Thomas, DJ
Bradham, K
AF Juhasz, Albert L.
Smith, Euan
Nelson, Clay
Thomas, David J.
Bradham, Karen
TI Variability Associated with As in Vivo-in Vitro Correlations When Using
Different Bioaccessibility Methodologies
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CONTAMINATED SOILS; ARSENIC BIOAVAILABILITY; RELATIVE BIOAVAILABILITY;
ORAL BIOAVAILABILITY; DIGESTION MODELS; RISK-ASSESSMENT; LEAD; ASSAY;
VALIDATION; ABSORPTION
AB To evaluate the capabilities of in vitro assays to predict arsenic (As) relative bioavailability (RBA), we examined the relationship between As bioaccessibility, determined using a number of in vitro bioaccessibility (IVBA) methodologies (SBRC, IVG, PBET, DIN and UBM) and As RBA determined in a mouse assay for nine As-contaminated soils and 1 NIST reference material (2710a). Significant differences (P < 0.05) in As IVBA were observed within and between assays indicating that different IVBA methodologies may not produce congruent data, as a result of variability in the extracting medium constituents and/or differences in the pH of gastric and intestinal phases. When results of in vivo determinations of As RBA were compared with As IVBA results, there was no significant difference in slopes of the relationships (P = 0.49-0.88) when SBRC, IVG, PBET, DIN, and UBM gastric and intestinal phase data were used. A significantly (P < 0.05) smaller y-intercept was, however, determined for the in vivo-SBRC gastric phase correlation compared to SBRC, IVG, PBET, and DIN intestinal phase, a factor that may influence prediction of As RBA, especially for soils with low As RBA. When in vivo-in vitro relationships were compared to previously derived correlations from the literature, some differences were observed. These differences may be attributed to factors affecting both in vivo and in vitro data including physiological differences in animal models (e.g., mouse versus swine), which may influence As absorption, differences in the approach used to estimate As RBA, and variability arising from subtle interoperator differences in performance of in vitro assays.
C1 [Juhasz, Albert L.; Smith, Euan] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia.
[Nelson, Clay; Thomas, David J.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Juhasz, AL (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia.
EM Albert.Juhasz@unisa.edu.au
RI Juhasz, Albert/F-6600-2011
OI Juhasz, Albert/0000-0002-1164-4085
FU Centre for Environmental Risk Assessment and Remediation, University of
South Australia; U.S. Environmental Protection Agency, Office of
Research and Development
FX The authors would like to acknowledge the support of the Centre for
Environmental Risk Assessment and Remediation, University of South
Australia, and the U.S. Environmental Protection Agency, Office of
Research and Development for this research. This article was reviewed in
accordance with the policy of the National Exposure Research Laboratory,
U.S. Environmental Protection Agency, and approved for publication.
Approval does not signify that the contents necessarily reflect the view
and policies of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 39
TC 12
Z9 12
U1 5
U2 54
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 7
PY 2014
VL 48
IS 19
BP 11646
EP 11653
DI 10.1021/es502751z
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AQ7RJ
UT WOS:000343016600078
PM 25157927
ER
PT J
AU Spanbauer, TL
Allen, CR
Angeler, DG
Eason, T
Fritz, SC
Garmestani, AS
Nash, KL
Stone, JR
AF Spanbauer, Trisha L.
Allen, Craig R.
Angeler, David G.
Eason, Tarsha
Fritz, Sherilyn C.
Garmestani, Ahjond S.
Nash, Kirsty L.
Stone, Jeffery R.
TI Prolonged Instability Prior to a Regime Shift
SO PLOS ONE
LA English
DT Article
ID EARLY-WARNING SIGNALS; FISHER INFORMATION; ECOLOGICAL-SYSTEMS;
MULTIDECADAL DROUGHT; CRITICAL TRANSITIONS; ROCKY-MOUNTAINS;
CLIMATE-CHANGE; ECOSYSTEM; TIME; RESILIENCE
AB Regime shifts are generally defined as the point of 'abrupt' change in the state of a system. However, a seemingly abrupt transition can be the product of a system reorganization that has been ongoing much longer than is evident in statistical analysis of a single component of the system. Using both univariate and multivariate statistical methods, we tested a long-term high-resolution paleoecological dataset with a known change in species assemblage for a regime shift. Analysis of this dataset with Fisher Information and multivariate time series modeling showed that there was a, 2000 year period of instability prior to the regime shift. This period of instability and the subsequent regime shift coincide with regional climate change, indicating that the system is undergoing extrinsic forcing. Paleoecological records offer a unique opportunity to test tools for the detection of thresholds and stable-states, and thus to examine the long-term stability of ecosystems over periods of multiple millennia.
C1 [Spanbauer, Trisha L.; Fritz, Sherilyn C.] Univ Nebraska, Dept Earth & Atmospher Sci, Lincoln, NE 68588 USA.
[Spanbauer, Trisha L.; Fritz, Sherilyn C.] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA.
[Allen, Craig R.] Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Res Unit, US Geol Survey, Lincoln, NE USA.
[Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, Uppsala, Sweden.
[Eason, Tarsha; Garmestani, Ahjond S.] US Environm Protect Agcy, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH USA.
[Nash, Kirsty L.] James Cook Univ, Australian Res Council Ctr Excellence Coral Reef, Townsville, Qld 4811, Australia.
[Stone, Jeffery R.] Indiana State Univ, Dept Earth & Environm Syst, Terre Haute, IN 47809 USA.
RP Spanbauer, TL (reprint author), Univ Nebraska, Dept Earth & Atmospher Sci, Lincoln, NE 68588 USA.
EM tspanbauer@unl.edu
RI Nash, Kirsty/B-5456-2015
OI Nash, Kirsty/0000-0003-0976-3197
FU U.S. Geological Survey; Nebraska Game and Parks Commission; University
of Nebraska-Lincoln; United States Fish and Wildlife Service; Wildlife
Management Institute; August T. Larsson Foundation of the Swedish
University of Agricultural Sciences; NSF's Integrative Graduate
Education and Research Traineeship (IGERT) program (NSF) [0903469];
Sedimentary Geology & Paleobiology program (NSF) [1251678]
FX The Nebraska Cooperative Fish and Wildlife Research Unit is jointly
supported by a cooperative agreement between the U.S. Geological Survey,
the Nebraska Game and Parks Commission, the University of
Nebraska-Lincoln, the United States Fish and Wildlife Service, and the
Wildlife Management Institute. This work was supported in part by the
August T. Larsson Foundation of the Swedish University of Agricultural
Sciences and the NSF's Integrative Graduate Education and Research
Traineeship (IGERT) program (NSF #0903469) and the Sedimentary Geology &
Paleobiology program (NSF #1251678). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 42
TC 15
Z9 15
U1 1
U2 38
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 3
PY 2014
VL 9
IS 10
AR e108936
DI 10.1371/journal.pone.0108936
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AQ3DZ
UT WOS:000342670800040
PM 25280010
ER
PT J
AU Chorley, BN
Nelson, G
Carswell, G
Mortensen, H
Crooks, J
Ward, W
Wood, C
Jackson, AF
Yauk, C
Recio, L
Hester, S
AF Chorley, Brian Norris
Nelson, Gail
Carswell, Gleta
Mortensen, Holly
Crooks, James
Ward, William
Wood, Charles
Jackson, Anna F.
Yauk, Carole
Recio, Les
Hester, Susan
TI Liver and blood miRNA alterations as putative biomarkers of hepatotoxic
response to short-term furan exposure in mice
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
(AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Chorley, Brian Norris; Nelson, Gail; Carswell, Gleta; Mortensen, Holly; Crooks, James; Ward, William; Wood, Charles; Hester, Susan] US EPA, Durham, NC USA.
[Jackson, Anna F.] Carleton Univ, Ottawa, ON K1S 5B6, Canada.
[Yauk, Carole] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Recio, Les] Integrated Syst Lab Inc, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 5226
DI 10.1158/1538-7445.AM2014-5226
PG 1
WC Oncology
SC Oncology
GA CB8VR
UT WOS:000349910204177
ER
PT J
AU Weinstein, JN
Kim, J
Creighton, CJ
Akbani, R
Hoadley, KA
Kim, WY
Morgan, MB
Hinoue, T
Cherniack, A
Su, X
Mungall, AJ
Ryan, MC
Rosenberg, JE
Bajorin, DF
Czerniak, B
Hansel, D
Reuter, VE
Robinson, BD
Al-Ahmadie, HA
Damrauer, JS
Zhang, W
Liu, Y
Gordenin, D
Stuart, JM
Schultz, N
Robertson, G
Kucherlapati, R
Laird, PW
Mills, GB
Kwiatkowski, DJ
Lerner, SP
AF Weinstein, John N.
Kim, Jaegil
Creighton, Chad J.
Akbani, Rehan
Hoadley, Katherine A.
Kim, William Y.
Morgan, Margaret B.
Hinoue, Toshinori
Cherniack, Andrew
Su, Xiaoping
Mungall, Andrew J.
Ryan, Michael C.
Rosenberg, Jonathan E.
Bajorin, Dean F.
Czerniak, Bogdan
Hansel, Donna
Reuter, Victor E.
Robinson, Brian D.
Al-Ahmadie, Hikmat A.
Damrauer, Jeffrey S.
Zhang, Wei
Liu, Yuexin
Gordenin, Dmitry
Stuart, Joshua M.
Schultz, Nikolaus
Robertson, Gordon
Kucherlapati, Raju
Laird, Peter W.
Mills, Gordon B.
Kwiatkowski, David J.
Lerner, Seth P.
CA TCGAs Bladder Canc Working Grp
TI Comprehensive characterization of urothelial bladder cancer: a TCGA
Project update
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 105th Annual Meeting of the American-Association-for-Cancer-Research
(AACR)
CY APR 05-09, 2014
CL San Diego, CA
SP Amer Assoc Canc Res
C1 [Weinstein, John N.; Akbani, Rehan; Su, Xiaoping] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
[Kim, Jaegil; Cherniack, Andrew] MIT, Broad Inst, Cambridge, MA 02139 USA.
[Kim, Jaegil; Cherniack, Andrew] Harvard Univ, Cambridge, MA 02138 USA.
[Creighton, Chad J.] Baylor Coll Med, Human Genome Sequencing Ctr, Dan L Duncan Canc Ctr, Houston, TX 77030 USA.
[Hoadley, Katherine A.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
[Kim, William Y.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
[Morgan, Margaret B.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
[Hinoue, Toshinori; Laird, Peter W.] Univ So Calif, Epigenome Ctr, Los Angeles, CA USA.
[Mungall, Andrew J.; Robertson, Gordon] Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada.
[Ryan, Michael C.] In Silico Solut, Fairfax, VA USA.
[Rosenberg, Jonathan E.; Bajorin, Dean F.; Reuter, Victor E.; Al-Ahmadie, Hikmat A.; Schultz, Nikolaus] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Czerniak, Bogdan; Zhang, Wei; Liu, Yuexin] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Hansel, Donna] UCSD Dept Pathol, San Diego, CA USA.
[Robinson, Brian D.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA.
[Damrauer, Jeffrey S.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Gordenin, Dmitry] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Stuart, Joshua M.] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA.
[Kucherlapati, Raju] Harvard Univ, Sch Med, Partners HealthCare Ctr Genet & Genom, Boston, MA USA.
[Mills, Gordon B.] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA.
[Kwiatkowski, David J.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Lerner, Seth P.] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD OCT 1
PY 2014
VL 74
IS 19
SU S
MA 987
DI 10.1158/1538-7445.AM2014-987
PG 2
WC Oncology
SC Oncology
GA CB8UN
UT WOS:000349906905454
ER
PT J
AU Newcomer Johnson, TA
Kaushal, SS
Mayer, PM
Grese, MM
AF Newcomer Johnson, Tamara A.
Kaushal, Sujay S.
Mayer, Paul M.
Grese, Melissa M.
TI Effects of stormwater management and stream restoration on watershed
nitrogen retention
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Denitrification; Hydrologic connectivity; Floodplains; Stormwater
management; Stream restoration; Urban watershed continuum approach
ID URBAN LANDSCAPE; LAND-USE; ECOSYSTEM RESTORATION; RIPARIAN ZONES;
DEGRADED URBAN; ORGANIC-CARBON; CHESAPEAKE BAY; DENITRIFICATION;
GROUNDWATER; NUTRIENT
AB Restoring urban infrastructure and managing the nitrogen cycle represent emerging challenges for urban water quality. We investigated whether stormwater control measures (SCMs), a form of green infrastructure, integrated into restored and degraded urban stream networks can influence watershed nitrogen loads. We hypothesized that hydrologically connected floodplains and SCMs are "hot spots" for nitrogen removal through denitrification because they have ample organic carbon, low dissolved oxygen levels, and extended hydrologic residence times. We tested this hypothesis by comparing nitrogen retention metrics in two urban stream networks (one restored and one urban degraded) that each contain SCMs, and a forested reference watershed at the Baltimore Long-Term Ecological Research site. We used an urban watershed continuum approach which included sampling over both space and time with a combination of: (1) longitudinal reach-scale mass balances of nitrogen and carbon conducted over 2 years during baseflow and storms (n = 24 sampling dates x 15 stream reaches = 360) and (2) N-15 push-pull tracer experiments to measure in situ denitrification in SCMs and floodplain features (n = 72). The SCMs consisted of inline wetlands installed below a storm drain outfall at one urban site (restored Spring Branch) and a wetland/wet pond configured in an oxbow design to receive water during high flow events at another highly urbanized site (Gwynns Run). The SCMs significantly decreased total dissolved nitrogen (TDN) concentrations at both sites and significantly increased dissolved organic carbon concentrations at one site. At Spring Branch, TDN retention estimated by mass balance (g/day) was similar to 150 times higher within the stream network than the SCMs. There were no significant differences between mean in situ denitrification rates between SCMs and hydrologically connected floodplains. Longitudinal N budgets along the stream network showed that hydrologically connected floodplains were important sites for watershed nitrogen retention due to groundwater-surface water interactions. Overall, our results indicate that hydrologic variability can influence nitrogen source/sink dynamics along engineered stream networks. Our analysis also suggests that some major predictors for watershed N retention were: (1) streamwater and groundwater flux through stream restoration or stormwater management controls, (2) hydrologic residence times, and (3) surface area of hydrologically connected features.
C1 [Newcomer Johnson, Tamara A.; Kaushal, Sujay S.; Grese, Melissa M.] Univ Maryland, Dept Geol, College Pk, MD 20740 USA.
[Newcomer Johnson, Tamara A.; Kaushal, Sujay S.; Grese, Melissa M.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
[Mayer, Paul M.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Newcomer Johnson, TA (reprint author), NOAA, Natl Sea Grant Off, 1315 East West Highway SSMC 3 11876, Silver Spring, MD 20910 USA.
EM Tammy.Newcomer@NOAA.gov
RI Kaushal, Sujay/G-1062-2013; Newcomer Johnson, Tamara/D-1045-2013;
OI Kaushal, Sujay/0000-0003-0834-9189; Newcomer Johnson,
Tamara/0000-0002-2496-7641; Mayer, Paul/0000-0002-8550-1386
FU MD Sea Grant Awards [SA7528085-U, R/WS-2, NA05OAR4171042]; NSF [DBI
0640300, CBET 1058502]; EPA NNEMS Award [2010-308]; NASA [NASA
NNX11AM28G]; U.S. EPA Office of Research and Development; Baltimore
Ecosystem Study LTER project [NSF DEB-0423476]
FX This research was supported by MD Sea Grant Awards SA7528085-U, R/WS-2
and NA05OAR4171042, NSF Awards DBI 0640300 and CBET 1058502, EPA NNEMS
Award 2010-308, NASA grant NASA NNX11AM28G, the U.S. EPA Office of
Research and Development, and Baltimore Ecosystem Study LTER project
(NSF DEB-0423476). We thank Melanie Harrison, Jeff Campbell, Katie
Delaney-Newcomb, Gwen Sivirichi, Michael Pennino, Dan Dillon, Shuiwang
Duan, Casie Smith, and Rich Foot for assistance in the lab and field.
Steve Stewart, Prakash Mistry, and Bill Stack provided help with
selection of field sites and logistical support. The research has not
been subjected to U.S. Environmental Protection Agency review and
therefore does not necessarily reflect the views of any of the funding
agencies, and no official endorsement should be inferred.
NR 78
TC 3
Z9 3
U1 12
U2 80
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
EI 1573-515X
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD OCT
PY 2014
VL 121
IS 1
BP 81
EP 106
DI 10.1007/s10533-014-9999-5
PG 26
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA AP2NG
UT WOS:000341908600005
ER
PT J
AU Kitchin, KT
Grulke, E
Robinette, BL
Castellon, BT
AF Kitchin, Kirk T.
Grulke, Eric
Robinette, Brian L.
Castellon, Benjamin T.
TI Metabolomic effects in HepG2 cells exposed to four TiO2 and two CeO2
nanomaterials
SO ENVIRONMENTAL SCIENCE-NANO
LA English
DT Article
ID ULTRAFINE TITANIUM-DIOXIDE; CERIUM OXIDE NANOPARTICLES; OXIDATIVE
STRESS; IN-VITRO; PARTICLES; TOXICITY; CYTOTOXICITY; MECHANISMS;
STRATEGIES; SAFETY
AB It is difficult to evaluate nanomaterials potential toxicity and to make science-based societal choices. To better assess potential hepatotoxicity issues, human liver HepG2 cells were exposed to four TiO2 and two CeO2 nanomaterials at 30 ug ml(-1) for three days with dry mean primary particle sizes ranging from 8 to 142 nm. Two nanomaterials were also run at 3 ug ml(-1). A metabolomics study was then performed using three mass spectroscopy dependent platforms (LC and GC). Five of the six nanomaterials strongly reduced glutathione concentration. The two strongest effects were from exposures to a TiO2 (59 nm) and a CeO2 (8 nm), both from NanoAmor. The decreases in the GSH system were observed in (a) GSH precursors (glutamate and cysteine), (b) GSH itself and (c) GSH metabolites (the gamma-glutamyl condensation products with glutamate, glutamine, alanine, valine and also 5-oxoproline and cysteine-GSH). The glutathione decreases were the largest decreases seen among the 265 biochemical metabolites determined and is consistent with nanomaterials acting via an oxidative stress mode of action. CeO2, but not TiO2, increased asymmetric dimethylarginine concentration and thus possible decreases in iNOS activity and NO concentration could result. One CeO2 (8 nm from NanoAmor) increased concentrations of many lipids, particularly fatty acids. Similar statistically significant elevations were seen in several other classes of lipids (lysolipid, monoacylglycerol, diacylglycerol and sphingolipid) but not in all classes of lipids (glycerolipid, carnitine and fatty acid dicarboxylate). None of the other 5 nanomaterials had this lipid effect. Thus, metabolomic analysis of nanomaterial treated HepG2 cells revealed several previously unknown biochemical effects.
C1 [Kitchin, Kirk T.; Robinette, Brian L.; Castellon, Benjamin T.] US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Grulke, Eric] Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA.
RP Kitchin, KT (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, 109 Alexander Dr,Mail Drop B105-03, Res Triangle Pk, NC 27711 USA.
EM kitchin.kirk@epa.gov; eric.grulke@uky.edu; robinette.brian@epa.gov;
ben.castellon@gmail.com
RI Castellon, Benjamin/I-4117-2014
OI Castellon, Benjamin/0000-0001-8883-076X
NR 35
TC 9
Z9 9
U1 8
U2 31
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2051-8153
EI 2051-8161
J9 ENVIRON-SCI NANO
JI Environ.-Sci. Nano
PD OCT
PY 2014
VL 1
IS 5
BP 466
EP 477
DI 10.1039/c4en00096j
PG 12
WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience &
Nanotechnology
SC Chemistry; Environmental Sciences & Ecology; Science & Technology -
Other Topics
GA AZ1BC
UT WOS:000347974400006
ER
PT J
AU Lash, LH
Chiu, WA
Guyton, KZ
Rusyn, I
AF Lash, Lawrence H.
Chiu, Weihsueh A.
Guyton, Kathryn Z.
Rusyn, Ivan
TI Trichloroethylene biotransformation and its role in mutagenicity,
carcinogenicity and target organ toxicity
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Review
DE Cytochrome P450-dependent oxidation; Glutathione conjugation; Kidney;
Liver; Reactive intermediates; Trichloroethylene
ID CONJUGATE BETA-LYASE; GLUTAMINE TRANSAMINASE-K;
GLUTATHIONE-S-TRANSFERASE; PROXIMAL TUBULAR CELLS; FLAVIN-CONTAINING
MONOOXYGENASES; DISINFECTION BY-PRODUCTS; BASAL-LATERAL MEMBRANE;
UNSCHEDULED DNA-SYNTHESIS; RABBIT LIVER-MICROSOMES; HEALTH-RISK
ASSESSMENT
AB Metabolism is critical for the mutagenicity, carcinogenicity, and other adverse health effects of trichloroethylene (TCE). Despite the relatively small size and simple chemical structure of TCE, its metabolism is quite complex, yielding multiple intermediates and end-products. Experimental animal and human data indicate that TCE metabolism occurs through two major pathways: cytochrome P450 (CYP)-dependent oxidation and glutathione (GSH) conjugation catalyzed by GSH S-transferases (GSTs). Herein we review recent data characterizing ICE processing and flux through these pathways. We describe the catalytic enzymes, their regulation and tissue localization, as well as the evidence for transport and inter-organ processing of metabolites. We address the chemical reactivity of TCE metabolites, highlighting data on mutagenicity of these end-products. Identification in urine of key metabolites, particularly trichloroacetate (TCA), dichloroacetate (DCA), trichloroethanol and its glucuronide (TCOH and TCOG), and N-acetyl-S-(1,2-dichloroviny1)-L-cysteine (NAcDCVC), in exposed humans and other species (mostly rats and mice) demonstrates function of the two metabolic pathways in vivo. The CYP pathway primarily yields chemically stable end-products. However, the GST pathway conjugate S-(1,2-dichlorovinyl)glutathione (DCVG) is further processed to multiple highly reactive species that are known to be mutagenic, especially in kidney where in situ metabolism occurs. TCE metabolism is highly variable across sexes, species, tissues and individuals. Genetic polymorphisms in several of the key enzymes metabolizing TCE and its intermediates contribute to variability in metabolic profiles and rates. In all, the evidence characterizing the complex metabolism of TCE can inform predictions of adverse responses including mutagenesis, carcinogenesis, and acute and chronic organ-specific toxicity. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Lash, Lawrence H.] Wayne State Univ, Dept Pharmacol, Sch Med, Detroit, MI 48201 USA.
[Chiu, Weihsueh A.; Guyton, Kathryn Z.] US EPA, Washington, DC 20460 USA.
[Rusyn, Ivan] Univ N Carolina, Chapel Hill, NC 27599 USA.
RP Lash, LH (reprint author), Wayne State Univ, Dept Pharmacol, Sch Med, 540 East Canfield Ave, Detroit, MI 48201 USA.
EM l.h.lash@wayne.edu; Chiu.Weihsueh@epa.gov; guytonk@iarc.fr; iir@unc.edu
RI Rusyn, Ivan/S-2426-2016;
OI Lash, Lawrence/0000-0003-3239-4481
FU NIEHS NIH HHS [P42 ES005948]
NR 191
TC 13
Z9 15
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
EI 1388-2139
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD OCT-DEC
PY 2014
VL 762
BP 22
EP 36
DI 10.1016/j.mrrev.2014.04.003
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA AY4YY
UT WOS:000347582000002
PM 25484616
ER
PT J
AU Kelly, FL
Sun, J
Fischer, BM
Voynow, JA
Kummarapurugu, AB
Zhang, HL
Nugent, JL
Beasley, RF
Martinu, T
Gwinn, WM
Morgan, DL
Palmer, SM
AF Kelly, Francine L.
Sun, Jesse
Fischer, Bernard M.
Voynow, Judith A.
Kummarapurugu, Apparao B.
Zhang, Helen L.
Nugent, Julia L.
Beasley, Robert F.
Martinu, Tereza
Gwinn, William M.
Morgan, Daniel L.
Palmer, Scott M.
TI Diacetyl Induces Amphiregulin Shedding in Pulmonary Epithelial Cells and
in Experimental Bronchiolitis Obliterans
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE amphiregulin; TNF-alpha-converting enzyme; epidermal growth factor
receptor; diacetyl; bronchiolitis obliterans
ID EGFR LIGANDS; FIBROSIS; WORKERS; LUNG; EXPRESSION; NECROSIS; RATS; MICE
AB Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis. The epidermal growth factor receptor ligand, amphiregulin (AREG), has been implicated in other types of epithelial injury and lung fibrosis. We investigated the effects of DA directly on the pulmonary epithelium, and we hypothesized that DA exposure would result in epithelial cell shedding of AREG. Consistent with this hypothesis, we demonstrate that DA increases AREG by the pulmonary epithelial cell line NCI-H292 and by multiple independent primary human airway epithelial donors grown under physiologically relevant conditions at the air-liquid interface. Furthermore, we demonstrate that AREG shedding occurs through a TNF-alpha-converting enzyme (TACE)-dependent mechanism via inhibition of TACE activity in epithelial cells using the small molecule inhibitor, TNF-alpha protease inhibitor-1, as well as TACE-specific small inhibitor RNA. Finally, we demonstrate supportive in vivo results showing increased AREG transcript and protein levels in the lungs of rodents with DA-induced BO. In summary, our novel in vitro and in vivo observations suggest that further study of AREG is warranted in the pathogenesis of DA-induced BO.
C1 [Kelly, Francine L.; Sun, Jesse; Zhang, Helen L.; Nugent, Julia L.; Beasley, Robert F.; Martinu, Tereza; Palmer, Scott M.] Duke Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, Dept Med, Durham, NC 27710 USA.
[Fischer, Bernard M.; Voynow, Judith A.; Kummarapurugu, Apparao B.] Duke Univ, Med Ctr, Div Pediat Pulm & Sleep Med, Dept Med, Durham, NC 27710 USA.
[Gwinn, William M.; Morgan, Daniel L.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Kelly, FL (reprint author), Duke Univ, Med Ctr, Div Pulm & Crit Care Med, 2 Genome Court,DUMC 103002, Durham, NC 27710 USA.
EM fran.kelly@duke.edu
FU Roche Organs Transplant Foundation; National Institutes of Health [R01
ES016836]; Lung Transplant Foundation [R01 ES016836]; Alpha 1 Foundation
FX This work was supported by the Roche Organs Transplant Foundation and
the Lung Transplant Foundation, by National Institutes of Health grant
R01 ES016836 (J.A.V.), and by the Alpha 1 Foundation (B.M.F.).
NR 23
TC 7
Z9 8
U1 1
U2 6
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD OCT
PY 2014
VL 51
IS 4
BP 568
EP 574
DI 10.1165/rcmb.2013-0339OC
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KK
UT WOS:000347418700011
PM 24816162
ER
PT J
AU Lin, YS
Ho, WC
Caffrey, JL
Sonawane, B
AF Lin, Yu-Sheng
Ho, Wen-Chao
Caffrey, James L.
Sonawane, Babasaheb
TI Low serum zinc is associated with elevated risk of cadmium
nephrotoxicity
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Cadmium; Zinc; Albuminuria; Glomerular filtration rate; Kidney; Renal
ID NUTRITION EXAMINATION SURVEY; EXAMINATION SURVEY NHANES; CHRONIC
KIDNEY-DISEASE; 2ND NATIONAL-HEALTH; LOW-LEVEL CADMIUM; OXIDATIVE
STRESS; RENAL TOXICITY; EXPOSURE; PROTECTION; HYPERTENSION
AB Background: Despite animal evidence suggests that zinc modulates cadmium nephrotoxicity, limited human data are available.
Objective: To test the hypothesis that low serum zinc concentrations may increase the risk of cadmium-mediated renal dysfunction in humans.
Methods: Data from 1545 subjects aged 20 or older in the National Health and Nutrition Examination Survey (NHANES), 2011-2012 were analyzed. Renal function was defined as impaired when estimated glomerular filtration rate (eGFR) fell below 60 ml/min/1.73 m(2) and/or the urinary albumin-to-creatinine ratio surpassed 2.5 in men and 3.5 mg/mmol in women.
Results: Within the study cohort, 117 subjects had reduced eGFR and 214 had elevated urinary albumin. After adjusting for potential confounders, subjects with elevated blood cadmium (> 0.53 mu g/L) were more likely to have a reduced eGFR (odds ratio [OR]=2.21, 95% confidence interval [CI]: 1.09-4.50) and a higher urinary albumin (OR=2.04, 95% CI: 1.13-3.69) than their low cadmium (< 0.18 mu g/L) peers. In addition, for any given cadmium exposure, low serum zinc is associated with elevated risk of reduced eGFR (OR=3.38, 95% CI: 1.39-8.28). A similar increase in the odds ratio was observed between declining serum zinc and albuminuria but failed to reach statistical significance. Those with lower serum zinc/blood cadmium ratios were likewise at a greater risk of renal dysfunction (p < 0.01).
Conclusions: This study results suggest that low serum zinc concentrations are associated with an increased risk of cadmium nephrotoxicity. Elevated cadmium exposure is global public health issue and the assessment of zinc nutritional status may be an important covariate in determining its effective renal toxicity. Published by Elsevier Inc.
C1 [Lin, Yu-Sheng; Sonawane, Babasaheb] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Ho, Wen-Chao] China Med Univ, Coll Publ Hlth, Dept Publ Hlth, Taichung, Taiwan.
[Caffrey, James L.] Univ N Texas, Hlth Sci Ctr, Integrat Physiol & Cardiovasc Res Inst, Ft Worth, TX USA.
RP Lin, YS (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
EM Lin.Yu-Sheng@epa.gov
RI HO, WEN CHAO/M-1378-2013
NR 47
TC 5
Z9 5
U1 1
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD OCT
PY 2014
VL 134
SI SI
BP 33
EP 38
DI 10.1016/j.envres.2014.06.013
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX3CB
UT WOS:000346817100006
PM 25042034
ER
PT J
AU Lanzinger, S
Breitner, S
Neas, L
Cascio, W
Diaz-Sanchez, D
Hinderliter, A
Peters, A
Devlin, RB
Schneider, A
AF Lanzinger, Stefanie
Breitner, Susanne
Neas, Lucas
Cascio, Wayne
Diaz-Sanchez, David
Hinderliter, Alan
Peters, Annette
Devlin, Robert B.
Schneider, Alexandra
TI The impact of decreases in air temperature and increases in ozone on
markers of endothelial function in individuals having type-2 diabetes
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Endothelial dysfunction; Temperature; Ozone; Particulate matter;
Interactive effects; Epidemiology
ID FLOW-MEDIATED VASODILATION; CASE-CROSSOVER ANALYSIS; BRACHIAL-ARTERY;
CARDIOVASCULAR-DISEASE; OUTDOOR TEMPERATURE; CARDIAC EVENTS;
BLOOD-PRESSURE; POLLUTION; DYSFUNCTION; ASSOCIATION
AB Several studies have reported an association between air pollution and endothelial dysfunction, especially in individuals having diabetes. However, very few studies have examined the impact of air temperature on endothelial function. The objective of this analysis was to investigate short-term effects of temperature and ozone on endothelial function in individuals having diabetes. Moreover, we investigated interactive effects between air temperature and air pollution on markers of endothelial function. Between November 2004 and December 2005 flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NTGMD) and several blood markers representing endothelial function were measured using brachial artery ultrasound on four consecutive days in 22 individuals with type-2 diabetes mellitus in Chapel Hill, North Carolina (USA). Daily measurements of meteorological parameters, ozone and particulate matter with an aerodynamic diameter <= 2.5 mu m (PM2.5) were obtained from fixed monitoring sites. We used additive mixed-models adjusting for time trend, day of the week, relative humidity and barometric pressure to assess temperature and ozone associations with endothelial function. A 1 degrees C decrease in the 24-h temperature average was associated with a decrease in mean FMD on the same day (-2.2% (95%-confidence interval:[-4.7;0.3%])) and with a delay of one and four days. A temperature decrement also led to an immediate (-1.7[-3.3; -0.04]) decrease in NTGMD. Moreover, we observed an immediate (-14.6%[-263; -2.9%]) and a one day delayed (-13.5% [-27.0; 0.04%]) decrease in FMD in association with a 0.01 ppm increase in the maximum 8-h moving average of ozone. Temperature effects on FMD strengthened when PM2.5 and ozone concentrations were high. The associations were similar during winter and summer. We detected an association between temperature decreases and ozone increases on endothelial dysfunction in individuals having diabetes. We conclude that endothelial dysfunction might be a possible mechanism explaining cardiovascular events in association with environmental stimuli. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Lanzinger, Stefanie; Breitner, Susanne; Peters, Annette; Schneider, Alexandra] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
[Neas, Lucas; Cascio, Wayne; Diaz-Sanchez, David; Devlin, Robert B.] Environm Protect Agcy, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA.
[Hinderliter, Alan] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
RP Lanzinger, S (reprint author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
EM stefanie.lanzinger@helmholtz-muenchen.de
RI Peters, Annette/A-6117-2011; Schneider, Alexandra/B-5347-2014; Breitner,
Susanne/B-5348-2014
OI Breitner, Susanne/0000-0002-0956-6911
FU U.S. Environmental Protection Agency [CR83346301, RD832415]; General
Clinical Research Centers program of the Division of Research Resources,
National Institutes of Health [RR00046]; German Federal Ministry of
Education and Research (BMBF)
FX The study was partly funded through a U.S. Environmental Protection
Agency cooperative agreement CR83346301. The analysis was performed in
cooperation with the Helmholtz Zentrum Munchen - German Research Center
for Environmental Health, Institute of Epidemiology II and partly funded
by the U.S. Environmental Protection Agency through STAR grant RD832415
to the University of Rochester. The study was supported in part by a
grant (RR00046) from the General Clinical Research Centers program of
the Division of Research Resources, National Institutes of Health.
Moreover, this study was supported in part by a grant from the German
Federal Ministry of Education and Research (BMBF) to the German Center
for Diabetes Research (DZD e.V.). The research described in this paper
has been reviewed by the National Health and Environmental Effects
Research Laboratory, U.S. Environmental Protection Agency and approved
for publication. Approval does not signify that the contents necessarily
reflect the views and the policies of the Agency nor does mention of
trade names or commercial products constitute endorsement or
recommendation for use.
NR 33
TC 4
Z9 4
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD OCT
PY 2014
VL 134
SI SI
BP 331
EP 338
DI 10.1016/j.envres.2014.08.003
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX3CB
UT WOS:000346817100045
PM 25199974
ER
PT J
AU Messner, MJ
Berger, P
Nappier, SP
AF Messner, Michael J.
Berger, Philip
Nappier, Sharon P.
TI Fractional Poisson-A Simple Dose-Response Model for Human Norovirus
SO RISK ANALYSIS
LA English
DT Article
DE Beta-Poisson; dose-response; fractional Poisson; immunity; infection;
Norovirus
ID NORWALK VIRUS-INFECTION; UNITED-STATES; GASTROENTERITIS; SUSCEPTIBILITY;
OUTBREAKS; WATER
AB This study utilizes old and new Norovirus (NoV) human challenge data to model the dose-response relationship for human NoV infection. The combined data set is used to update estimates from a previously published beta-Poisson dose-response model that includes parameters for virus aggregation and for a beta-distribution that describes variable susceptibility among hosts. The quality of the beta-Poisson model is examined and a simpler model is proposed. The new model (fractional Poisson) characterizes hosts as either perfectly susceptible or perfectly immune, requiring a single parameter (the fraction of perfectly susceptible hosts) in place of the two-parameter beta-distribution. A second parameter is included to account for virus aggregation in the same fashion as it is added to the beta-Poisson model. Infection probability is simply the product of the probability of nonzero exposure (at least one virus or aggregate is ingested) and the fraction of susceptible hosts. The model is computationally simple and appears to be well suited to the data from the NoV human challenge studies. The model's deviance is similar to that of the beta-Poisson, but with one parameter, rather than two. As a result, the Akaike information criterion favors the fractional Poisson over the beta-Poisson model. At low, environmentally relevant exposure levels (<100), estimation error is small for the fractional Poisson model; however, caution is advised because no subjects were challenged at such a low dose. New low-dose data would be of great value to further clarify the NoV dose-response relationship and to support improved risk assessment for environmentally relevant exposures.
C1 [Messner, Michael J.; Berger, Philip; Nappier, Sharon P.] US EPA, Off Water, Washington, DC 20460 USA.
RP Messner, MJ (reprint author), US EPA, Mailcode 4607M,1200 Penn Ave NW, Washington, DC 20460 USA.
EM Messner.Michael@epa.gov
NR 24
TC 11
Z9 11
U1 1
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4332
EI 1539-6924
J9 RISK ANAL
JI Risk Anal.
PD OCT
PY 2014
VL 34
IS 10
BP 1820
EP 1829
DI 10.1111/risa.12207
PG 10
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA AU0NR
UT WOS:000345320600007
PM 24724739
ER
PT J
AU Phillips, DL
Inger, R
Bearhop, S
Jackson, AL
Moore, JW
Parnell, AC
Semmens, BX
Ward, EJ
AF Phillips, Donald L.
Inger, Richard
Bearhop, Stuart
Jackson, Andrew L.
Moore, Jonathan W.
Parnell, Andrew C.
Semmens, Brice X.
Ward, Eric J.
TI Best practices for use of stable isotope mixing models in food-web
studies
SO CANADIAN JOURNAL OF ZOOLOGY
LA English
DT Review
DE consumers; diet; food chain; isotopic ratios; trophic level
ID INCORPORATING CONCENTRATION-DEPENDENCE; DISCRIMINATION FACTORS
DELTA-N-15; CONSUMER-DIET; PRIOR INFORMATION; SEASONAL-CHANGES; CARBON
ISOTOPES; NITROGEN; ECOLOGY; DELTA-C-13; TURNOVER
AB Stable isotope mixing models are increasingly used to quantify consumer diets, but may be misused and misinterpreted. We address major challenges to their effective application. Mixing models have increased rapidly in sophistication. Current models estimate probability distributions of source contributions, have user-friendly interfaces, and incorporate complexities such as variability in isotope signatures, discrimination factors, hierarchical variance structure, covariates, and concentration dependence. For proper implementation of mixing models, we offer the following suggestions. First, mixing models can only be as good as the study and data. Studies should have clear questions, be informed by knowledge of the system, and have strong sampling designs to effectively characterize isotope variability of consumers and resources on proper spatio-temporal scales. Second, studies should use models appropriate for the question and recognize their assumptions and limitations. Decisions about source grouping or incorporation of concentration dependence can influence results. Third, studies should be careful about interpretation of model outputs. Mixing models generally estimate proportions of assimilated resources with substantial uncertainty distributions. Last, common sense, such as graphing data before analyzing, is essential to maximize usefulness of these tools. We hope these suggestions for effective implementation of stable isotope mixing models will aid continued development and application of this field.
C1 [Phillips, Donald L.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97330 USA.
[Inger, Richard; Bearhop, Stuart] Univ Exeter, Sch Biosci, Environm & Sustainabil Inst, Penryn TR10 9EZ, Cornwall, England.
[Jackson, Andrew L.] Univ Dublin Trinity Coll, Sch Nat Sci, Dept Zool, Dublin 2, Ireland.
[Moore, Jonathan W.] Simon Fraser Univ, Dept Biol Sci, Burnaby, BC V5A 1S6, Canada.
[Parnell, Andrew C.] Univ Coll Dublin, Sch Math Sci Stat, Complex & Adapt Syst Lab, Dublin 4, Ireland.
[Semmens, Brice X.] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
[Ward, Eric J.] NOAA, NW Fisheries Sci Ctr, Natl Marine Fisheries Serv, Seattle, WA 98112 USA.
RP Phillips, DL (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97330 USA.
EM phillips.donald@epa.gov
RI Jackson, Andrew/D-3441-2009; Parnell, Andrew/C-7284-2014; Inger,
Richard/D-3445-2009;
OI Jackson, Andrew/0000-0001-7334-0434; Parnell,
Andrew/0000-0001-7956-7939; Inger, Richard/0000-0003-1660-3706; Bearhop,
Stuart/0000-0002-5864-0129
FU U.S. Environmental Protection Agency (EPA)
FX The information in this review has been funded in part by the U.S.
Environmental Protection Agency (EPA). It has been subjected to the
Agency's peer and administrative review and has been approved for
publication as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use by
the EPA. We thank K. A. Hobson and A. L. Bond for constructive comments
on an earlier draft.
NR 98
TC 83
Z9 84
U1 19
U2 157
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4301
EI 1480-3283
J9 CAN J ZOOL
JI Can. J. Zool.
PD OCT
PY 2014
VL 92
IS 10
BP 823
EP 835
DI 10.1139/cjz-2014-0127
PG 13
WC Zoology
SC Zoology
GA AT6EF
UT WOS:000345031300001
ER
PT J
AU Arunachalam, S
Valencia, A
Akita, Y
Serre, ML
Omary, M
Garcia, V
Isakov, V
AF Arunachalam, Saravanan
Valencia, Alejandro
Akita, Yasuyuki
Serre, Marc L.
Omary, Mohammad
Garcia, Valerie
Isakov, Vlad
TI A Method for Estimating Urban Background Concentrations in Support of
Hybrid Air Pollution Modeling for Environmental Health Studies
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE air quality model; human exposure; background concentration; kriging;
STOK; on-road emissions; traffic; NOx; PM2.5
ID NEAR-ROAD EXPOSURES; POPULATION EXPOSURES; DISPERSION MODEL; POLLUTANTS;
CMAQ; EPIDEMIOLOGY; METRICS; SYSTEM; NEXUS
AB Exposure studies rely on detailed characterization of air quality, either from sparsely located routine ambient monitors or from central monitoring sites that may lack spatial representativeness. Alternatively, some studies use models of various complexities to characterize local-scale air quality, but often with poor representation of background concentrations. A hybrid approach that addresses this drawback combines a regional-scale model to provide background concentrations and a local-scale model to assess impacts of local sources. However, this approach may double-count sources in the study regions. To address these limitations, we carefully define the background concentration as the concentration that would be measured if local sources were not present, and to estimate these background concentrations we developed a novel technique that combines space-time ordinary kriging (STOK) of observations with outputs from a detailed chemistry-transport model with local sources zeroed out. We applied this technique to support an exposure study in Detroit, Michigan, for several pollutants (including NOx and PM2.5), and evaluated the estimated hybrid concentrations (calculated by combining the background estimates that addresses this issue of double counting with local-scale dispersion model estimates) using observations. Our results demonstrate the strength of this approach specifically by eliminating the problem of double-counting reported in previous hybrid modeling approaches leading to improved estimates of background concentrations, and further highlight the relative importance of NOx vs. PM2.5 in their relative contributions to total concentrations. While a key limitation of this approach is the requirement for another detailed model simulation to avoid double-counting, STOK improves the overall characterization of background concentrations at very fine spatial scales.
C1 [Arunachalam, Saravanan; Valencia, Alejandro; Omary, Mohammad] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA.
[Akita, Yasuyuki; Serre, Marc L.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Garcia, Valerie; Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Arunachalam, S (reprint author), Univ N Carolina, Inst Environm, 100 Europa Dr,Suite 490, Chapel Hill, NC 27517 USA.
EM sarav@email.unc.edu; valenal@email.unc.edu; akita@email.unc.edu;
marc_serre@unc.edu; omary@email.unc.edu; Garcia.Val@epa.gov;
Isakov.Vlad@epa.gov
OI serre, marc/0000-0003-3145-4024
FU U.S. Environmental Protection Agency through Office of Research and
Development [EP-D-07-102, EP-W-09-023]
FX We gratefully acknowledge the U.S. EPA's Atmospheric Modeling and
Analysis Division (AMAD) for providing the base case CMAQ simulation
used in this work, and Elizabeth Adams of UNC for her assistance with
the CMAQ simulations performed for this research. We also thank the two
anonymous reviewers for their insightful comments that greatly helped
improve the overall paper. The U.S. Environmental Protection Agency,
through its Office of Research and Development, partially funded and
collaborated in the research described here under Contract Nos.
EP-D-07-102 and EP-W-09-023 to the University of North Carolina at
Chapel Hill. This paper has been subjected to Agency review and approved
for publication. Approval does not signify that the contents reflect the
views of the Agency nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 28
TC 5
Z9 5
U1 2
U2 23
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2014
VL 11
IS 10
BP 10518
EP 10536
DI 10.3390/ijerph111010518
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AS6FA
UT WOS:000344358700035
PM 25321872
ER
PT J
AU Seo, M
Lee, S
Kim, JH
Lee, WH
Hu, G
Elledge, SJ
Suk, K
AF Seo, Minchul
Lee, Shinrye
Kim, Jong-Heon
Lee, Won-Ha
Hu, Guang
Elledge, Stephen J.
Suk, Kyoungho
TI RNAi-based functional selection identifies novel cell migration
determinants dependent on PI3K and AKT pathways
SO NATURE COMMUNICATIONS
LA English
DT Article
ID POTENTIAL THERAPEUTIC TARGET; PUTATIVE TUMOR-SUPPRESSOR; PROTEIN-KINASE
CK2; CANCER CELL; REGULATORY SUBUNIT; CYCLE PROGRESSION; OVARIAN-CANCER;
BREAST-CANCER; HUMAN-DISEASE; KAPPA-B
AB Lentiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying loss-of-function phenotype in mammalian cells. Here, we report the identification of 91 cell migration-regulating genes using unbiased genome-wide functional genetic selection. Individual knockdown or cDNA overexpression of a set of 10 candidates reveals that most of these cell migration determinants are strongly dependent on the PI3K/PTEN/AKT pathway and on their downstream signals, such as FOXO1 and p70S6K1. ALK, one of the cell migration promoting genes, uniquely uses p55 gamma regulatory subunit of PI3K, rather than more common p85 subunit, to trigger the activation of the PI3K-AKT pathway. Our method enables the rapid and cost-effective genome-wide selection of cell migration regulators. Our results emphasize the importance of the PI3K/PTEN/AKT pathway as a point of convergence for multiple regulators of cell migration.
C1 [Seo, Minchul; Lee, Shinrye; Kim, Jong-Heon; Suk, Kyoungho] Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Dept Pharmacol,Brain Sci & Engn Inst, Taegu, South Korea.
[Seo, Minchul] Dongguk Univ, Coll Med, Gyeongju, South Korea.
[Lee, Shinrye] Korea Brain Res Inst, Taegu, South Korea.
[Lee, Won-Ha] Kyungpook Natl Univ, Sch Life Sci & Biotechnol, KNU Creat BioRes Grp, Taegu, South Korea.
[Hu, Guang] Natl Inst Environm Hlth & Sci, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA.
[Elledge, Stephen J.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Genet,Howard Hughes Med Inst,Div Genet, Boston, MA 02115 USA.
RP Suk, K (reprint author), Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Dept Pharmacol,Brain Sci & Engn Inst, Taegu, South Korea.
EM ksuk@knu.ac.kr
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
[2008-0062282, 2012M3A9B6055414]; Korean Health technology R&D Project,
Ministry of Health & Welfare, Republic of Korea [A111345]; DOD Breast
Cancer Innovator Award; SU2C at Howard Hughes Medical Institute
FX This work was supported by the National Research Foundation of Korea
(NRF) grant funded by the Korea government (MSIP) (Nos 2008-0062282 and
2012M3A9B6055414) and by a grant from the Korean Health technology R&D
Project, Ministry of Health & Welfare, Republic of Korea (A111345). This
work was also supported by a DOD Breast Cancer Innovator Award and a
grant from SU2C to S.J.E. at the Howard Hughes Medical Institute. The
authors thank Dr Young-il Park at Young-il Sciences Inc. (Daegu, Korea)
for generously providing Incucyte and Woundmaker (Essen BioScience, Ann
Arbor, MI).
NR 70
TC 5
Z9 6
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2014
VL 5
AR 5217
DI 10.1038/ncomms6217
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS0QO
UT WOS:000343982800006
PM 25347953
ER
PT J
AU Sundstrom, SM
Angeler, DG
Garmestani, AS
Garcia, JH
Allen, CR
AF Sundstrom, Shana M.
Angeler, David G.
Garmestani, Ahjond S.
Garcia, Jorge-H.
Allen, Craig R.
TI Transdisciplinary Application of Cross-Scale Resilience
SO SUSTAINABILITY
LA English
DT Article
DE complex adaptive systems; cross-scale dynamics; discontinuities;
quantitative resilience; multidisciplinary application;
social-ecological systems
ID COMPLEX ADAPTIVE SYSTEMS; CITY SIZE DISTRIBUTIONS; SOCIAL-ECOLOGICAL
SYSTEMS; BODY-MASS DISTRIBUTIONS; FOOD WEBS; REGIME SHIFTS; CRITICAL
TRANSITIONS; FUNCTIONAL RICHNESS; RELATIVE RESILIENCE; ECOSYSTEM
SERVICES
AB The cross-scale resilience model was developed in ecology to explain the emergence of resilience from the distribution of ecological functions within and across scales, and as a tool to assess resilience. We propose that the model and the underlying discontinuity hypothesis are relevant to other complex adaptive systems, and can be used to identify and track changes in system parameters related to resilience. We explain the theory behind the cross-scale resilience model, review the cases where it has been applied to non-ecological systems, and discuss some examples of social-ecological, archaeological/anthropological, and economic systems where a cross-scale resilience analysis could add a quantitative dimension to our current understanding of system dynamics and resilience. We argue that the scaling and diversity parameters suitable for a resilience analysis of ecological systems are appropriate for a broad suite of systems where non-normative quantitative assessments of resilience are desired. Our planet is currently characterized by fast environmental and social change, and the cross-scale resilience model has the potential to quantify resilience across many types of complex adaptive systems.
C1 [Sundstrom, Shana M.] Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Unit, Lincoln, NE 68583 USA.
[Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, SE-75007 Uppsala, Sweden.
[Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Garcia, Jorge-H.] CICERO, Ctr Int Climate & Environm Res, N-0349 Oslo, Norway.
[Allen, Craig R.] Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Unit, US Geol Survey, Lincoln, NE 68583 USA.
RP Sundstrom, SM (reprint author), Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Unit, Lincoln, NE 68583 USA.
EM sundstrom.shana@gmail.com; david.angeler@slu.se;
garmestani.ahjond@epa.gov; j.h.garcia@cicero.oslo.no; allencr@unl.edu
OI Sundstrom, Shana/0000-0003-0823-8008
FU Natural Sciences and Engineering Research Council of Canada; August T.
Larsson foundation (NJ Faculty, Swedish University of Agricultural
Sciences); USGS; Nebraska Game and Parks Commission; University of
Nebraska-Lincoln; US Fish and Wildlife Service; Wildlife Management
Institute
FX Shana M. Sundstrom was supported by an assistantship from the University
of Nebraska-Lincoln School of Natural Resources, and by a Natural
Sciences and Engineering Research Council of Canada doctoral grant. The
views expressed in this paper are those of the authors and do not
represent the views or policies of the U.S. Environmental Protection
Agency. Support from the August T. Larsson foundation (NJ Faculty,
Swedish University of Agricultural Sciences) is acknowledged. The
Nebraska Cooperative Fish and Wildlife Research Unit is jointly
supported by a cooperative agreement between the USGS, the Nebraska Game
and Parks Commission, the University of Nebraska-Lincoln, the US Fish
and Wildlife Service and the Wildlife Management Institute.
NR 147
TC 5
Z9 6
U1 6
U2 43
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2071-1050
J9 SUSTAINABILITY-BASEL
JI Sustainability
PD OCT
PY 2014
VL 6
IS 10
BP 6925
EP 6948
DI 10.3390/su6106925
PG 24
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences;
Environmental Studies
SC Science & Technology - Other Topics; Environmental Sciences & Ecology
GA AS6DU
UT WOS:000344355700023
ER
PT J
AU Jensen, ET
Daniels, JL
Sturmer, T
Robinson, WR
Williams, CJ
Moster, D
Juliusson, PB
Vejrup, K
Magnus, P
Longnecker, MP
AF Jensen, E. T.
Daniels, J. L.
Stuermer, T.
Robinson, W. R.
Williams, C. J.
Moster, D.
Juliusson, P. B.
Vejrup, K.
Magnus, P.
Longnecker, M. P.
TI Maternal hormonal contraceptive use and offspring overweight or obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID GESTATIONAL DIABETES-MELLITUS; BIRTH-WEIGHT; ORAL-CONTRACEPTIVES;
RISK-FACTORS; UNITED-STATES; EXPOSURE; PREGNANCY; METABOLISM; CHILDHOOD;
CHILDREN
AB BACKGROUND/OBJECTIVES: Experiments in animal models have shown a positive association between in utero exposure to pharmacologic sex hormones and offspring obesity. The developmental effects of such hormones on human obesity are unknown.
SUBJECTS/METHODS: Using data from a large, prospective pregnancy cohort study (n = 19 652), with linkage to a national prescription registry, we evaluated the association between use of hormonal contraceptives before and after conception (defined from dispensed prescription data and characterized by last date of use relative to conception, 12 to >4 months before (n = 3392), 4 to >1 months before (n = 2541), 1 to >0 months before (n = 2997) and 0-12 weeks after (n = 567)) in relation to offspring overweight or obesity at age 3 years.
RESULTS: We observed a weak, inverse association between early pregnancy use of a combination oral contraceptive and offspring overweight or obesity at age 3 (adjusted odds ratio (OR): 0.75, 95% confidence interval (CI): 0.53, 1.08) and a positive, but imprecise, association with use of a progestin-only oral contraceptive in early pregnancy (adjusted OR: 1.26, 95% CI: 0.79, 2.02). In general, no association was observed between the use of a hormonal contraceptive before conception and offspring overweight or obesity. A sensitivity analysis comparing combination oral contraceptive users in early pregnancy to other unplanned pregnancies without hormonal contraceptive use further strengthened the inverse association (adjusted OR: 0.70, 95% CI: 0.48, 1.02). Other sensitivity analyses were conducted to evaluate the robustness of the associations observed given varying assumptions.
CONCLUSIONS: Pharmacologic sex hormones in early pregnancy may be inversely or positively associated with offspring overweight or obesity at age 3, depending on the specific formulation used. The present study provides support for the potential for environmental sources of hormonally active agents to exert developmental effects.
C1 [Jensen, E. T.; Williams, C. J.; Longnecker, M. P.] Natl Inst Environm Hlth Sci, Dept Epidemiol, NIH, Res Triangle Pk, NC 27709 USA.
[Jensen, E. T.; Daniels, J. L.; Stuermer, T.; Robinson, W. R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
[Moster, D.] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
[Juliusson, P. B.] Univ Bergen, Dept Clin Sci, Bergen, Norway.
[Vejrup, K.; Magnus, P.] Natl Inst Publ Hlth, Div Epidemiol, Oslo, Norway.
RP Jensen, ET (reprint author), Natl Inst Environm Hlth Sci, Dept Epidemiol, NIH, POB 12233,Mail Drop A3-05, Res Triangle Pk, NC 27709 USA.
EM elizabeth.jensen@nih.gov
RI Jensen, Elizabeth/L-1466-2016;
OI Longnecker, Matthew/0000-0001-6073-5322
FU Intramural Research Program of the National Institutes of Health,
National Institute of Environmental Health Sciences [ES102985];
University of North Carolina institutional training grant award for
reproductive, perinatal, and pediatric epidemiology [T32HD052468];
National Cancer Institute [1K01CA172717- 01]; Carolina Population Center
[R24 HD050924]; Norwegian Ministry of Health [N01-ES-75558]; NIH/NIEHS;
NIH/National Institute of Neurological Disorders and Stroke [1 UO1 NS
047537-01]; Norwegian Research Council/FUGE [151918/S10]
FX We are grateful to all the participating families in Norway who took
part in this ongoing cohort study. This work was supported in part by
the Intramural Research Program of the National Institutes of Health,
National Institute of Environmental Health Sciences (ES102985 to CJW),
the University of North Carolina institutional training grant award for
reproductive, perinatal, and pediatric epidemiology (grant T32HD052468
to ETJ), the National Cancer Institute (1K01CA172717- 01 to WRR), and
the Carolina Population Center (R24 HD050924 to WRR). The Norwegian
Mother and Child Cohort Study is supported by the Norwegian Ministry of
Health, contract N01-ES-75558 with the NIH/NIEHS, NIH/National Institute
of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01) and the
Norwegian Research Council/FUGE (grant 151918/S10).
NR 59
TC 3
Z9 3
U1 1
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2014
VL 38
IS 10
BP 1275
EP 1281
DI 10.1038/ijo.2014.114
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AR6CA
UT WOS:000343669200003
PM 24984751
ER
PT J
AU Wong, K
Bouchard, D
Molina, M
AF Wong, Kelvin
Bouchard, Dermont
Molina, Marirosa
TI Relative transport of human adenovirus and MS2 in porous media
SO COLLOIDS AND SURFACES B-BIOINTERFACES
LA English
DT Article
DE Adenovirus; MS2; Fate and transport; Filtration; Ionic strength;
Deposition
ID SAND COLUMNS; DEPOSITION KINETICS; VIRUS RETENTION; ENTERIC VIRUSES;
ORGANIC-MATTER; SOIL; AGGREGATION; SALMONELLA; BACTERIOPHAGES;
ATTACHMENT
AB Human adenovirus (HAdV) is the most prevalent enteric virus found in the water environment by numerous monitoring studies and MS2 is the most common surrogate used for previous virus transport studies. However, the current knowledge on the transport behavior of HAdV in porous media and the transport relationship between HAdV and MS2 is very limited. In this study, we investigated the influence of ionic strength (IS) on the transport behaviors of HAdV, MS2, and pilus-associated MS2 (p-MS2) in saturated quartz sand columns. Retention of HAdV was higher than MS2 in all three IS (1, 10 and 100 mM NaCl), especially in 10 and 100 mM where virus recoveries in the effluent samples were <= 1% for HAdV, but >= 55% for MS2. Derjaguin and Landau, Verwey and Overbeek (DLVO) theory alone cannot explain why the deposition of HAdV was so much higher. HAdV retention may be strongly enhanced by attaching its long fibers to the sand surface and this deposition mechanism is supported by DLVO energy profiles which show that HAdV can approach the sand surface within reach of its fibers at 10 and 100 mM NaCl. Results of transmission electron microscopy, dynamic light scattering and 0.05 mu m membrane filtration suggest that the majority of MS2 cultured by Escherichia coli Famp were associated with a residue of pill. Although retention of pilus-associated MS2 (p-MS2) in the column was just slightly higher than individual MS2 particles, membrane filtration results indicated potentially important differences between removal of MS2 and p-MS2 by filtration with finer pore sizes. This is the first study reporting (1) increasing differences in the transport of HAdV and MS2 in porous media with an increase in ionic strength; (2) significant influence of pilus-association to MS2 removal by membrane and porous media filtration; and (3) a mechanistic explanation for the deposition differences of HAdV and MS2 using virus morphology information and DLVO theory. Published by Elsevier B.V.
C1 [Wong, Kelvin; Bouchard, Dermont; Molina, Marirosa] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Wong, K (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM wong.kelvin@epa.gov; molina.marirosa@epa.gov
NR 44
TC 4
Z9 4
U1 6
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-7765
EI 1873-4367
J9 COLLOID SURFACE B
JI Colloid Surf. B-Biointerfaces
PD OCT 1
PY 2014
VL 122
BP 778
EP 784
DI 10.1016/j.colsurfb.2014.08.020
PG 7
WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials
SC Biophysics; Chemistry; Materials Science
GA AR5GK
UT WOS:000343612900097
PM 25194593
ER
PT J
AU Keith, DJ
AF Keith, Darryl J.
TI Satellite remote sensing of chlorophyll a in support of nutrient
management in the Neuse and Tar-Pamlico River (North Carolina) estuaries
SO REMOTE SENSING OF ENVIRONMENT
LA English
DT Article
DE MERIS; Chlorophyll a; Nutrient management; Estuaries; Neuse River;
Tar-Pamlico River
ID WATER-QUALITY; SOUND ESTUARY; PHYTOPLANKTON; USA; RESPONSES
AB The North Carolina Environmental Management Commission (EMC) has adopted as a water quality standard that chlorophyll a concentration should not exceed 40 mu g/L in sounds, estuaries and other slow-moving waters. In 1996, nutrient load reductions were placed into North Carolina (NC) law to reduce the extent and duration of algal blooms in the Neuse and Tar River estuaries (Session Law 1995, Section 572). The chlorophyll a criterion was used as the endpoint to manage total nitrogen concentrations, and compliance would be achieved if chl a exceedances occurred in fewer than 10% of the samples collected in a specified area and time (known as the 10/40 criterion).
In 2009, discussions were held between the North Carolina Department of Environmental and Natural Resources (NCDENR) and US Environmental Protection Agency (EPA) concerning the practicality of using satellite-derived chl a concentrations to monitor water quality, enforce water quality-related environmental regulations, and understand the environmental impacts of the watershed land-use practices on coastal waters.
In this study, the MERIS chlorophyll a data product was used to conduct a retrospective analysis of the NC standard for water quality and Total Maximum Daily Load (TMDL) for total nitrogen in the Neuse and Tar-Pamlico River estuaries from 2006 to 2009. From daily MERIS images, compliance and chlorophyll exceedances in the Neuse and Tar-Pamlico River estuaries were assessed at daily and aggregated to annual time scales. Published by Elsevier Inc.
C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Keith, DJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM keith.darryl@epa.gov
FU U.S. Environmental Protection Agency Office of Research and Development
(ORD) Safe and Sustainable Waters Research Program
FX This is EPA publication EPA/600/RS-13/247. The information in this
document has been funded wholly by the U.S. Environmental Protection
Agency Office of Research and Development (ORD) Safe and Sustainable
Waters Research Program. It has been subjected to review by the ORD
National Health and Environmental Effects Research Laboratory and
approved for publication. The MERIS data used for this work were
provided by the European Space Agency. The mention of trade names or
commercial products in this manuscript does not constitute endorsement
or recommendation for use.
NR 39
TC 2
Z9 2
U1 3
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0034-4257
EI 1879-0704
J9 REMOTE SENS ENVIRON
JI Remote Sens. Environ.
PD OCT
PY 2014
VL 153
BP 61
EP 78
DI 10.1016/j.rse.2014.05.019
PG 18
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
Photographic Technology
GA AR5KI
UT WOS:000343623300006
ER
PT J
AU Koustas, E
Lam, J
Sutton, P
Johnson, PI
Atchley, DS
Sen, S
Robinson, K
Axelrad, DA
Woodruff, TJ
AF Koustas, Erica
Lam, Juleen
Sutton, Patrice
Johnson, Paula I.
Atchley, Dylan S.
Sen, Saunak
Robinson, Karen A.
Axelrad, Daniel A.
Woodruff, Tracey J.
TI The Navigation Guide-Evidence-Based Medicine Meets Environmental Health:
Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID AMMONIUM PERFLUOROOCTANOATE APFO; RESTRICTED GESTATIONAL EXPOSURES;
MAMMARY-GLAND DEVELOPMENT; NATIONAL BIRTH COHORT; DEVELOPMENTAL
TOXICITY; SERUM CONCENTRATIONS; POLYFLUOROALKYL COMPOUNDS;
PERFLUORINATED CHEMICALS; PERFLUOROALKYL ACIDS; CARBOXYLIC-ACIDS
AB BACKGROUND: In contrast to current methods of expert-based narrative review, the Navigation Guide is a systematic and transparent method for synthesizing environmental health research from multiple evidence streams. The Navigation Guide was developed to effectively and efficiently translate the available scientific evidence into timely prevention-oriented action.
OBJECTIVES: We applied the Navigation Guide systematic review method to answer the question "Does fetal developmental exposure to perfluoro-octanoic acid (PFOA) or its salts affect fetal growth in animals ?" and to rate the strength of the experimental animal evidence.
METHODS: We conducted a comprehensive search of the literature, applied prespecified criteria to the search results to identify relevant studies, extracted data from studies, obtained additional information from study authors, conducted meta-analyses, and rated the overall quality and strength of the evidence.
RESULTS: Twenty-one studies met the inclusion criteria. From the meta-analysis of eight mouse gavage data sets, we estimated that exposure of pregnant mice to increasing concentrations of PFOA was associated with a change in mean pup birth weight of -0.023 g (95% CI: -0.029, -0.016) per 1-unit increase in dose (milligrams per kilogram body weight per day). The evidence, consisting of 15 mammalian and 6 nonmammalian studies, was rated as "moderate" and "low" quality, respectively.
CONCLUSION: Based on this first application of the Navigation Guide methodology, we found sufficient evidence that fetal developmental exposure to PFOA reduces fetal growth in animals.
C1 [Koustas, Erica; Lam, Juleen] US EPA, Oak Ridge Inst Sci & Educ ORISE Postdoctoral Fell, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA.
[Sutton, Patrice; Johnson, Paula I.; Atchley, Dylan S.; Woodruff, Tracey J.] Univ Calif San Francisco, Program Reprod Hlth & Environm, Oakland, CA USA.
[Sen, Saunak] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Robinson, Karen A.] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA.
[Robinson, Karen A.] Johns Hopkins Sch Med, Dept Epidemiol, Baltimore, MD USA.
[Robinson, Karen A.] Johns Hopkins Sch Med, Baltimore, MD USA.
[Axelrad, Daniel A.] US EPA, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA.
RP Koustas, E (reprint author), US EPA, 1200 Penn Ave NW,1809T, Washington, DC 20460 USA.
EM koustas.erica@epa.gov
FU Internship/Research Participation Program at the National Center for
Environmental Economics, U.S. EPA; New York Community Trust; U.S. EPA
[GAIA-0-6-UCSF 17288]; Clarence Heller Foundation; Passport Foundation;
Forsythia Foundation; Johnson Family Foundation; Heinz Endowments; Fred
Gellert Foundation; Rose Foundation; Kaiser Permanente; Philip R. Lee
Institute for Health Policy Studies; Planned Parenthood Federation of
America; National Institute of Environmental Health Sciences [ES018135,
ESO22841]; U.S. EPA STAR [RD83467801, RD83543301]
FX This research was supported, in part, by appointments of E.K. and J.L.
to the Internship/Research Participation Program at the National Center
for Environmental Economics, U.S. EPA, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and the U.S. EPA. T.J.W. is a
member of the Philip R. Lee Institute for Health Policy Studies.
Financial support for development of the PFOA case study was through
grants from the New York Community Trust and the U.S. EPA through a
contract with Abt Associates (GAIA-0-6-UCSF 17288). For 2009-2013,
support for the development and dissemination of the Navigation Guide
methodology was provided by the Clarence Heller Foundation, the Passport
Foundation, the Forsythia Foundation, the Johnson Family Foundation, the
Heinz Endowments, the Fred Gellert Foundation, the Rose Foundation,
Kaiser Permanente, the New York Community Trust, the Philip R. Lee
Institute for Health Policy Studies, the Planned Parenthood Federation
of America, the National Institute of Environmental Health Sciences
(grants ES018135 and ESO22841), and U.S. EPA STAR grants (RD83467801 and
RD83543301).
NR 87
TC 32
Z9 32
U1 3
U2 32
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2014
VL 122
IS 10
BP 1015
EP 1027
DI 10.1289/ehp.1307177
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AQ9BO
UT WOS:000343136200013
PM 24968374
ER
PT J
AU Johnson, PI
Sutton, P
Atchley, DS
Koustas, E
Lam, J
Sen, S
Robinson, KA
Axelrad, DA
Woodruff, TJ
AF Johnson, Paula I.
Sutton, Patrice
Atchley, Dylan S.
Koustas, Erica
Lam, Juleen
Sen, Saunak
Robinson, Karen A.
Axelrad, Daniel A.
Woodruff, Tracey J.
TI The Navigation Guide-Evidence-Based Medicine Meets Environmental Health:
Systematic Review of Human Evidence for PFOA Effects on Fetal Growth
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID PERFLUOROOCTANOIC ACID EXPOSURE; NATIONAL BIRTH COHORT; PERFLUORINATED
CHEMICALS; PERFLUOROALKYLATED SUBSTANCES; DRINKING-WATER; SERUM-LEVELS;
PREGNANCY; WEIGHT; SULFONATE; RISK
AB BACKGROUND: The Navigation Guide methodology was developed to meet the need for a robust method of systematic and transparent research synthesis in environmental health science. We conducted a case study systematic review to support proof of concept of the method.
OBJECTIVE: We applied the Navigation Guide systematic review methodology to determine whether developmental exposure to perfluorooctanoic acid (PFOA) affects fetal growth in humans.
METHODS: We applied the first 3 steps of the Navigation Guide methodology to human epidemiological data: 1) specify the study question, 2) select the evidence, and 3) rate the quality and strength of the evidence. We developed a protocol, conducted a comprehensive search of the literature, and identified relevant studies using prespecified criteria. We evaluated each study for risk of bias and conducted meta-analyses on a subset of studies. We rated quality and strength of the entire body of human evidence.
RESULTS: We identified 18 human studies that met our inclusion criteria, and 9 of these were combined through meta-analysis. Through meta-analysis, we estimated that a 1-ng/mL increase in serum or plasma PFOA was associated with a -18.9 g (95% CI: -29.8, -7.9) difference in birth weight. We concluded that the risk of bias across studies was low, and we assigned a "moderate" quality rating to the overall body of human evidence.
CONCLUSION: On the basis of this first application of the Navigation Guide systematic review methodology, we concluded that there is "sufficient" human evidence that developmental exposure to PFOA reduces fetal growth.
C1 [Johnson, Paula I.; Sutton, Patrice; Atchley, Dylan S.; Woodruff, Tracey J.] Univ Calif San Francisco, Program Reprod Hlth & Environm, Oakland, CA USA.
[Koustas, Erica; Lam, Juleen] US EPA, Oak Ridge Inst Sci & Educ ORISE Postdoctoral Fell, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA.
[Sen, Saunak] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Med, Baltimore, MD USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Hlth Policy & Management, Baltimore, MD 21218 USA.
[Axelrad, Daniel A.] US EPA, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA.
RP Johnson, PI (reprint author), Calif Dept Publ Hlth, Occupat Hlth Branch, 850 Marina Bay Pkwy,Bldg P, Richmond, CA 94804 USA.
EM paula.johnson@cdph.ca.gov
FU New York Community Trust; U.S. EPA [GAIA-0-6-UCSF 17288];
Internship/Research Participation Program at the National Center for
Environmental Economics, U.S. EPA; Clarence Heller Foundation; Passport
Foundation; Forsythia Foundation; Johnson Family Foundation; Heinz
Endowments; Fred Gellert Foundation; Rose Foundation; Kaiser Permanente;
UCSF Institute for Health Policy Studies; Planned Parenthood Federation
of America; National Institute of Environmental Health Sciences
[ES018135, ESO22841]; U.S. EPA STAR [RD83467801, RD83543301]
FX This research was funded through grants from New York Community Trust
and the U.S. EPA through a contract with Abt Associates (GAIA-0-6-UCSF
17288). E.K. and J.L. were supported in part by appointments to the
Internship/Research Participation Program at the National Center for
Environmental Economics, U.S. EPA, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and the U.S. EPA. For 2009-2013,
support for the development and dissemination of the Navigation Guide
methodology was provided by the Clarence Heller Foundation, the Passport
Foundation, the Forsythia Foundation, the Johnson Family Foundation, the
Heinz Endowments, the Fred Gellert Foundation, the Rose Foundation,
Kaiser Permanente, the New York Community Trust, the UCSF Institute for
Health Policy Studies, Planned Parenthood Federation of America,
National Institute of Environmental Health Sciences (ES018135 and
ESO22841), and U.S. EPA STAR grants (RD83467801 and RD83543301). T.J.W
is a faculty member at the Philip R. Lee Institute for Health Policy
Studies, UCSF.
NR 67
TC 48
Z9 48
U1 4
U2 34
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2014
VL 122
IS 10
BP 1028
EP 1039
DI 10.1289/ehp.1307893
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AQ9BO
UT WOS:000343136200014
PM 24968388
ER
PT J
AU Lam, J
Koustas, E
Sutton, P
Johnson, PI
Atchley, DS
Sen, S
Robinson, K
Axelrad, DA
Woodruff, TJ
AF Lam, Juleen
Koustas, Erica
Sutton, Patrice
Johnson, Paula I.
Atchley, Dylan S.
Sen, Saunak
Robinson, Karen A.
Axelrad, Daniel A.
Woodruff, Tracey J.
TI The Navigation Guide-Evidence-Based Medicine Meets Environmental Health:
Integration of Animal and Human Evidence for PFOA Effects on Fetal
Growth
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID PERFLUOROOCTANOIC ACID PFOA; PERFLUORINATED COMPOUNDS; EPIDEMIOLOGIC
EVIDENCE; DRINKING-WATER; BIRTH-WEIGHT; PERFLUOROALKYLATED SUBSTANCES;
PUBLICATION BIAS; SERUM-LEVELS; EXPOSURE; QUALITY
AB BACKGROUND: The Navigation Guide is a novel systematic review method to synthesize scientific evidence and reach strength of evidence conclusions for environmental health decision making.
OBJECTIVE: Our aim was to integrate scientific findings from human and nonhuman studies to determine the overall strength of evidence for the question "Does developmental exposure to perfluorooctanoic acid (PFOA) affect fetal growth in humans?"
METHODS: We developed and applied prespecified criteria to systematically and transparently a) rate the quality of the scientific evidence as "high," "moderate," or "low"; b) rate the strength of the human and nonhuman evidence separately as "sufficient," "limited," "moderate," or "evidence of lack of toxicity"; and c) integrate the strength of the human and nonhuman evidence ratings into a strength of the evidence conclusion.
RESULTS: We identified 18 epidemiology studies and 21 animal toxicology studies relevant to our study question. We rated both the human and nonhuman mammalian evidence as "moderate" quality and "sufficient" strength. Integration of these evidence ratings produced a final strength of evidence rating in which review authors concluded that PFOA is " known to be toxic" to human reproduction and development based on sufficient evidence of decreased fetal growth in both human and nonhuman mammalian species.
CONCLUSION: We concluded that developmental exposure to PFOA adversely affects human health based on sufficient evidence of decreased fetal growth in both human and nonhuman mammalian species. The results of this case study demonstrate the application of a systematic and transparent methodology, via the Navigation Guide, for reaching strength of evidence conclusions in environmental health.
C1 [Lam, Juleen; Koustas, Erica] US EPA, Oak Ridge Inst Sci & Educ ORISE Postdoctoral Fell, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA.
[Sutton, Patrice; Johnson, Paula I.; Atchley, Dylan S.; Woodruff, Tracey J.] Univ Calif San Francisco, Program Reprod Hlth & Environm, Oakland, CA USA.
[Sen, Saunak] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Hlth Policy & Management, Baltimore, MD 21218 USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Med, Baltimore, MD USA.
[Robinson, Karen A.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA.
[Axelrad, Daniel A.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Lam, J (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 624 N Broadway,Room 412, Baltimore, MD 21205 USA.
EM jlam5@jhu.edu
FU Internship/Research Participation Program at the National Center for
Environmental Economics, U.S. EPA; Environmental Defense Fund
(Washington, DC); U.S. EPA [GAIA-0-6-UCSF 17288]; New York Community
Trust; UCSF Program on Reproductive Health and the Environment by the
Clarence Heller Foundation; Passport Foundation; Forsythia Foundation;
Johnson Family Foundation; Heinz Endowments; Fred Gellert Foundation;
Rose Foundation; Kaiser Permanente; UCSF Institute for Health Policy
Studies; Planned Parenthood Federation of America; National Institute of
Environmental Health Sciences [ES018135, ESO22841]; U.S. EPA STAR
[RD83467801, RD83543301]
FX The research was supported in part by appointments of J.L. and E. K. to
the Internship/Research Participation Program at the National Center for
Environmental Economics, U.S. EPA, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and the U.S. EPA. T.J.W. is a
member of the Philip R. Lee Institute for Health Policy Studies, UCSF.
J.L. was partially funded by the Environmental Defense Fund (Washington,
DC). This research was also funded by the U.S. EPA through a contract
with Abt Associates (GAIA-0-6-UCSF 17288) and grants from the New York
Community Trust. For 2009-2013, financial support for the development
and dissemination of the Navigation Guide methodology on which this case
study was based was provided to the UCSF Program on Reproductive Health
and the Environment by the Clarence Heller Foundation, the Passport
Foundation, the Forsythia Foundation, the Johnson Family Foundation, the
Heinz Endowments, the Fred Gellert Foundation, the Rose Foundation,
Kaiser Permanente, the New York Community Trust, the UCSF Institute for
Health Policy Studies, Planned Parenthood Federation of America, the
National Institute of Environmental Health Sciences (ES018135 and
ESO22841), and U.S. EPA STAR grants (RD83467801 and RD83543301).
NR 84
TC 30
Z9 30
U1 6
U2 42
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2014
VL 122
IS 10
BP 1040
EP 1051
DI 10.1289/ehp.1307923
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AQ9BO
UT WOS:000343136200015
PM 24968389
ER
PT J
AU Markunas, CA
Xu, ZL
Harlid, S
Wade, PA
Lie, RT
Taylor, JA
Wilcox, AJ
AF Markunas, Christina A.
Xu, Zongli
Harlid, Sophia
Wade, Paul A.
Lie, Rolv T.
Taylor, Jack A.
Wilcox, Allen J.
TI Identification of DNA Methylation Changes in Newborns Related to
Maternal Smoking during Pregnancy
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; NICOTINE DEPENDENCE; DEVELOPMENTAL ORIGINS;
PARENTAL SMOKING; EXPRESSION; DISEASE; GALNT2; ACTIVATION; SMOKERS;
FRMD4A
AB BACKGROUND: Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have long-lasting effects is through epigenetic modifications such as DNA methylation.
OBJECTIVES: We conducted an epigenome-wide association study (EWAS) investigating alterations in DNA methylation in infants exposed in utero to maternal tobacco smoke, using the Norway Facial Clefts Study.
METHODS: The Illumina HumanMethylation450 BeadChip was used to assess DNA methylation in whole blood from 889 infants shortly after delivery. Of 889 mothers, 287 reported smoking-twice as many smokers as in any previous EWAS of maternal smoking. CpG sites related to maternal smoking during the first trimester were identified using robust linear regression.
RESULTS: We identified 185 CpGs with altered methylation in infants of smokers at genome-wide significance (q-value < 0.05; mean Delta beta = +/- 2%). These correspond to 110 gene regions, of which 7 have been previously reported and 10 are newly confirmed using publicly available results. Among these 10, the most noteworthy are FRMD4A, ATP9A, GALNT2, and MEG3, implicated in processes related to nicotine dependence, smoking cessation, and placental and embryonic development.
CONCLUSIONS: Our study identified 10 genes with newly established links to maternal smoking. Further, we note differences between smoking-related methylation changes in newborns and adults, suggesting possible distinct effects of direct versus indirect tobacco smoke exposure as well as potential differences due to age. Further work would be needed to determine whether these small changes in DNA methylation are biologically or clinically relevant. The methylation changes identified in newborns may mediate the association between in utero maternal smoking exposure and later health outcomes.
C1 [Markunas, Christina A.; Xu, Zongli; Taylor, Jack A.; Wilcox, Allen J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Harlid, Sophia; Wade, Paul A.; Taylor, Jack A.] Natl Inst Environm Hlth Sci, Lab Mol Carcinogenesis, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Lie, Rolv T.] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
[Lie, Rolv T.] Norwegian Inst Publ Hlth, Med Birth Registry Norway, Bergen, Norway.
RP Wilcox, AJ (reprint author), Natl Inst Environm Hlth Sci, POB 12233,Mail Drop A3-05, Res Triangle Pk, NC 27709 USA.
EM wilcox1@niehs.nih.gov
OI Harlid, Sophia/0000-0001-8540-6891; xu, zongli/0000-0002-9034-8902;
Wilcox, Allen/0000-0002-3376-1311; taylor, jack/0000-0001-5303-6398
FU Intramural Research Program of the National Institutes of Health,
National Institute of Environmental Health Sciences
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences.
NR 47
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Z9 49
U1 4
U2 25
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2014
VL 122
IS 10
BP 1147
EP 1153
DI 10.1289/ehp.1307892
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AQ9BO
UT WOS:000343136200030
PM 24906187
ER
PT J
AU Birnbaum, LS
Tart, KT
AF Birnbaum, Linda S.
Tart, Kimberly Thigpen
TI Protecting Our Children from Climate Change
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Editorial Material
C1 [Birnbaum, Linda S.; Tart, Kimberly Thigpen] Natl Inst Environm Hlth Sci, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
RP Birnbaum, LS (reprint author), Natl Inst Environm Hlth Sci, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
EM birnbaumls@niehs.nih.gov
NR 5
TC 1
Z9 1
U1 0
U2 9
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2014
VL 122
IS 10
BP A260
EP A261
DI 10.1289/ehp.1409165
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AQ9BO
UT WOS:000343136200001
PM 25271472
ER
PT J
AU Collins, SE
Flotemersch, JE
AF Collins, S. E.
Flotemersch, J. E.
TI EVALUATION OF THE SOUNDING ROD METHOD FOR SAMPLING COARSE RIVERBED
SEDIMENTS IN NON-WADEABLE STREAMS AND RIVERS
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE Substrate; sediment; assessment; copper-pole method; pole drag; physical
habitat
ID HABITAT ASSESSMENT; BIODIVERSITY
AB The substrate of fluvial systems is regularly characterized as part of a larger physical habitat assessment. These measures are instrumental in meeting the regulatory responsibilities of bioassessment and monitoring programs, and essential to monitoring restoration and rehabilitation success. We describe and validate a commonly used technique for broadly categorizing, and thus characterizing, the substrate in non-wadeable streams and rivers called the sounding rod method. In brief, a rod, often hollow, is used to probe the substrate of non-wadeable systems to characterize the substrate. We tested the viability of this method on three different systems by comparing estimated particle class and direct particle measurements. Our results indicate that substrates can adequately be defined into six broad classes (fine-particle sediment, sand, gravel, cobble, boulder and bedrock) based on size using the sounding rod. Estimated classes were significantly positively correlated to measured classes (tau = 0.83, p< 0.001), and estimates of size class and direct measurements of size were not from significantly different distributions (chi(2)(0.05,9) = 569.51, p< 0.001). Further, there were significant differences between each category (H= 243.5, 3 d.f., p< 0.001). Although our results affirm that actual substrate class size can be directly inferred from estimated data, it should be noted that soft sediments <200mm were not always detected. This finding should be carefully considered with individual study objective. Overall, the sounding rod method can be learned quickly, and it is a low-cost and time-efficient method for substrate classification. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Collins, S. E.; Flotemersch, J. E.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Collins, S. E.] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH USA.
RP Flotemersch, JE (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM flotemersch.joseph@epa.gov
FU US EPA [EP10D000363]
FX This paper received US EPA review and was approved for publication. US
EPA Student Services Contract agreement EP10D000363 to Sean Collins
partially funded the research described here. We thank Michael Moeykens,
Stephen Matter, Megan Lamkin, Natasha Urban, Matt Westbrook and the
anonymous reviewers for their critical reviews of the manuscript. We
also thank Phil Kaufmann for his insight into this topic.
NR 38
TC 2
Z9 3
U1 2
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD OCT
PY 2014
VL 30
IS 8
BP 1065
EP 1069
DI 10.1002/rra.2697
PG 5
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA AQ7YY
UT WOS:000343038000012
ER
PT J
AU Raimondo, S
Jackson, CR
Krzykwa, J
Hemmer, BL
Awkerman, JA
Barron, MG
AF Raimondo, Sandy
Jackson, Crystal R.
Krzykwa, Julie
Hemmer, Becky L.
Awkerman, Jill A.
Barron, Mace G.
TI Developmental toxicity of Louisiana crude oil-spiked sediment to
zebrafish
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE South Louisiana crude oil; Sediment exposure; Embryo development;
Toxicity; Zebrafish
ID EARLY-LIFE STAGES; GULF-OF-MEXICO; RISK-ASSESSMENT;
EMBRYONIC-DEVELOPMENT; SALT MARSHES; FISH; SPILL; IMPACTS; EXPOSURE
AB Embryonic exposures to the components of petroleum, including polycyclic aromatic hydrocarbons (PAHs), cause a characteristic suite of developmental defects and cardiotoxicity in a variety of fish species. We exposed zebrafish embryos to reference sediment mixed with laboratory weathered South Louisiana crude oil and to sediment collected from an oiled site in Barataria Bay, Louisiana in December 2010. Laboratory oiled sediment exposures caused a reproducible set of developmental malformations in zebrafish embryos including yolk sac and pericardial edema, craniofacial and spinal defects, and tissue degeneration. Dose-response studies with spiked sediment showed that total polycyclic aromatic hydrocarbons (tPAH) concentrations of 27 mg tPAH/kg (dry weight normalized to 1 percent organic carbon [1 percent OC]) caused a significant increase in defects, and concentrations above 78 mg tPAH/kg 1 percent OC caused nearly complete embryo mortality. No toxicity was observed in Barataria sediment with 2 mg tPAH/kg 1 percent OC. Laboratory aging of spiked sediment at 4 degrees C resulted in a nearly 10-fold decrease in sensitivity over a 40-day period. This study demonstrates oiled sediment as an exposure pathway to fish with dose-dependent effects on embryogenesis that are consistent with PAH mechanisms of developmental toxicity. The results have implications for effects on estuarine fish from oiled coastal areas during the Deepwater Horizon spill. Published by Elsevier Inc.
C1 [Raimondo, Sandy; Jackson, Crystal R.; Krzykwa, Julie; Hemmer, Becky L.; Awkerman, Jill A.; Barron, Mace G.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Raimondo, S (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM Raimondo.sandy@epa.gov
NR 31
TC 8
Z9 8
U1 3
U2 83
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD OCT
PY 2014
VL 108
BP 265
EP 272
DI 10.1016/j.ecoenv.2014.07.020
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AQ3XW
UT WOS:000342727800036
PM 25105486
ER
PT J
AU Sierszen, ME
Hrabik, TR
Stockwell, JD
Cotter, AM
Hoffman, JC
Yule, DL
AF Sierszen, Michael E.
Hrabik, Thomas R.
Stockwell, Jason D.
Cotter, Anne M.
Hoffman, Joel C.
Yule, Daniel L.
TI Depth gradients in food-web processes linking habitats in large lakes:
Lake Superior as an exemplar ecosystem
SO FRESHWATER BIOLOGY
LA English
DT Article
DE aquatic habitats; food web; Great Lakes; stable isotopes; trophic
linkages
ID HERRING COREGONUS-ARTEDI; STABLE-ISOTOPE ANALYSES; TROUT
SALVELINUS-NAMAYCUSH; SMELT OSMERUS-MORDAX; DEEP-WATER; FISH COMMUNITY;
CULTURAL EUTROPHICATION; VERTICAL-DISTRIBUTION; POPULATION-DYNAMICS;
AMPHIPOD DIPOREIA
AB In large lakes around the world, depth-based changes in the abundance and distribution of invertebrate and fish species suggest that there may be concomitant changes in patterns of resource allocation. Using Lake Superior of the Laurentian Great Lakes as an example, we explored this idea through stable isotope analyses of 13 major fish taxa. Patterns in carbon and nitrogen isotope ratios revealed use of both littoral and profundal benthos among populations of most taxa analysed regardless of the depth of their habitat, providing evidence of nearshore-offshore trophic linkages in the largest freshwater lake by area in the world. Isotope-mixing model results indicated that the overall importance of benthic food-web pathways to fish was highest in nearshore species, whereas the importance of planktonic pathways increased in offshore species. These characteristics, shared with the Great Lakes of Africa, Russia and Japan, appear to be governed by two key processes: high benthic production in nearshore waters and the prevalence of diel vertical migration (DVM) among offshore invertebrate and fish taxa. DVM facilitates use of pelagic food resources by deep-water biota and represents an important process of trophic linkage among habitats in large lakes. Support of whole-lake food webs through trophic linkages among pelagic, profundal and littoral habitats appears to be integral to the functioning of large lakes. These linkages can be disrupted though ecosystem disturbance such as eutrophication or the effects of invasive species and should be considered in native species restoration efforts.
C1 [Sierszen, Michael E.; Cotter, Anne M.; Hoffman, Joel C.] US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Ecol Effects Res Lab, Duluth, MN 55804 USA.
[Hrabik, Thomas R.] Univ Minnesota, Duluth, MN 55812 USA.
[Stockwell, Jason D.] Univ Vermont, Burlington, VT USA.
[Yule, Daniel L.] US Geol Survey, Lake Super Biol Stn, Ashland, WI USA.
RP Sierszen, ME (reprint author), US EPA, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM sierszen.michael@epa.gov
FU Minnesota Sea Grant [R/F-15]
FX We wish to thank Aisha Beaty, Andrew Just and Corlis West for preparing
fish samples for analysis; the Captain and crew of the R/V Kiyi for
collecting fish samples; and Shawn Sitar for providing humper lake trout
samples and diet information. Sample collection was partially supported
by Minnesota Sea Grant R/F-15 to TRH and JDS. The manuscript was greatly
improved through constructive comments by Robert Hecky, Donald Phillips
and Daniel Schindler. The views expressed in this paper are those of the
authors and do not necessarily reflect the views or policies of the US
Environmental Protection Agency. This is also contribution number 1866
of the USGS Great Lakes Science Center. Any use of trade, product or
firm names is for descriptive purposes only and does not imply
endorsement by the US Government.
NR 89
TC 12
Z9 12
U1 10
U2 77
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0046-5070
EI 1365-2427
J9 FRESHWATER BIOL
JI Freshw. Biol.
PD OCT
PY 2014
VL 59
IS 10
BP 2122
EP 2136
DI 10.1111/fwb.12415
PG 15
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA AQ4IO
UT WOS:000342758300009
ER
PT J
AU Hudson, R
Feng, YT
Varma, RS
Moores, A
AF Hudson, Reuben
Feng, Yuting
Varma, Rajender S.
Moores, Audrey
TI Bare magnetic nanoparticles: sustainable synthesis and applications in
catalytic organic transformations
SO GREEN CHEMISTRY
LA English
DT Review
ID SOLVENT-FREE CONDITIONS; ASYMMETRIC TRANSFER HYDROGENATION; NANOSCALE
IRON PARTICLES; LIGAND-FREE CONDITIONS; EFFICIENT CATALYST;
AMMONIA-BORANE; HETEROGENEOUS CATALYSIS; FERRITE NANOPARTICLES; PYRROLE
HYDROGENATION; FE3O4 NANOPARTICLES
AB Magnetic nanoparticles have become increasingly attractive in the field of catalysis over the last decade as they combine interesting reactivity with an easy, economical and environmentally benign mode of recovery. Early strategies focused on the use of such nanoparticles as a vehicle for supporting other catalytic nanomaterials or molecules to facilitate recovery. More recently, research has shown that bare magnetic nanoparticles may serve the dual rote of a catalyst and a magnetically recoverable entity. At the same time, emerging sustainability concepts emphasize the utility of earth abundant and less toxic resources, especially iron. Herein, we review the recent progress made in the assembly of such systems and their direct application in catalysis. Examples of such bare nanoparticles include iron oxide (Fe2O3 and Fe3O4), metal ferrites (MFe2O4, M = Cu, Co and Ni), Fe(0), Co(0), Ni(0), and multi-component nanoparticles. Features such as reactivity, recoverability and leaching are discussed in a critical fashion.
C1 [Hudson, Reuben; Feng, Yuting; Moores, Audrey] McGill Univ, Dept Chem, Ctr Catalysis & Green Chem, Montreal, PQ H3A 0B8, Canada.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Hudson, R (reprint author), McGill Univ, Dept Chem, Ctr Catalysis & Green Chem, Otto Maass Chem Bldg,801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada.
EM Varma.Rajender@epa.gov; audrey.moores@mcgill.ca
RI Moores, Audrey/C-9997-2011;
OI Moores, Audrey/0000-0003-1259-913X; Hudson, Reuben/0000-0001-9612-681X
FU Natural Science and Engineering Research Council of Canada (NSERC);
Canada Foundation for Innovation (CFI); Canada Research Chairs (CRC);
Fonds de Recherche sur la Nature et les Technologies (FQRNT); Centre for
Green Chemistry and Catalysis (CGCC); Green Chemistry - NSERC
Collaborative Research and Training Experience (CREATE) Program; McGill
University
FX We thank Natural Science and Engineering Research Council of Canada
(NSERC), the Canada Foundation for Innovation (CFI), the Canada Research
Chairs (CRC), the Fonds de Recherche sur la Nature et les Technologies
(FQRNT), the Centre for Green Chemistry and Catalysis (CGCC), the Green
Chemistry - NSERC Collaborative Research and Training Experience
(CREATE) Program, and McGill University for financial support. Vanessa
Chazelle is acknowledged for her artistic contributions and Samuel
Bastien and Nadi Braidy for insightful comments.
NR 153
TC 60
Z9 60
U1 7
U2 168
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PD OCT
PY 2014
VL 16
IS 10
BP 4493
EP 4505
DI 10.1039/c4gc00418c
PG 13
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA AQ5ZA
UT WOS:000342885900003
ER
PT J
AU Powers, C
Hendren, C
Wang, A
Davis, JM
AF Powers, Christina
Hendren, Christine
Wang, Amy
Davis, J. Michael
TI Transparent Stakeholder Engagement in Practice: Lessons Learned from
Applying Comprehensive Environmental Assessment to Research Planning for
Nanomaterials
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Article
ID MULTICRITERIA DECISION-ANALYSIS; LIFE-CYCLE ASSESSMENT; ENGINEERED
NANOMATERIALS; RISK-ASSESSMENT; EXPERT JUDGMENT; HUMAN HEALTH;
NANOTECHNOLOGY; NANOPARTICLES; EXPOSURE; IDENTIFICATION
AB As efforts to develop new applications of engineered nanoscale materials (ENMs) continue to grow, so too has interest in the environmental, health, and safety (EHS) implications of these materials. However, thorough evaluation and interpretation of such implications could require substantial resources (e.g., estimated as >$120 million per year in federal funding 2013-2017). A structured, strategic approach for transparently planning research would support improved linkages between ENM research and risk assessments, and thereby enhance the utility of financial and other resources for EHS studies of ENMs. For this reason, we applied Comprehensive Environmental Assessment (CEA) as an approach to provide transparent input into research planning for 2 types of ENMs: nanoscale titanium dioxide and nanoscale silver. For each of these CEA applications, we employed a collective judgment method known as Nominal Group Technique (NGT) in 2 workshops sponsored by the US Environmental Protection Agency (USEPA). The objective of this paper is to present the outcomes of these CEA applications in the context of how our methodology can inform future efforts to identify collective goals in science (e.g., research priorities) through structured decision support approaches. Outcomes include clear lists of research priorities for each ENM developed through transparently engaging stakeholders having diverse technical and sector perspectives. In addition, we identified several procedural aspects that could be refined, including emphasizing breakout group interactions, identifying broad information priorities before more detailed research questions, and using rating rather than ranking prioritization methods. Beyond the research directions identified for specific ENMs, lessons learned about engaging stakeholders in research planning are expected to inform future research planning efforts for ENMs and other emerging materials across the scientific community. Integr Environ Assess Manag 2014;10:498-510. (c) 2014 SETAC
C1 [Powers, Christina] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Hendren, Christine] Duke Univ, CEINT, Durham, NC USA.
[Wang, Amy] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Davis, J. Michael] US EPA Natl Ctr Environm Assessment, Pittsboro, NC USA.
EM davis.jmichael@mindspring.com
NR 56
TC 1
Z9 1
U1 2
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD OCT
PY 2014
VL 10
IS 4
BP 498
EP 510
DI 10.1002/ieam.1537
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AQ2KZ
UT WOS:000342616200006
PM 24729532
ER
PT J
AU Rudd, MA
Ankley, GT
Boxall, ABA
Brooks, BW
AF Rudd, Murray A.
Ankley, Gerald T.
Boxall, Alistair B. A.
Brooks, Bryan W.
TI International Scientists' Priorities for Research on Pharmaceutical and
Personal Care Products in the Environment
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Article
ID RESEARCH QUESTIONS; ENDOCRINE DISRUPTORS; BIOLOGICAL DIVERSITY;
CONSERVATION POLICY; MANAGEMENT POLICY; HEALTH; PRINCIPLES; MAKERS;
DESIGN; MODELS
AB Pharmaceuticals and personal care products (PPCPs) are widely discharged into the environment via diverse pathways. The effects of PPCPs in the environment have potentially important human and ecosystem health implications, so credible, salient, and legitimate scientific evidence is needed to inform regulatory and policy responses that address potential risks. A recent big questions exercise with participants largely from North America identified 22 important research questions around the risks of PPCP in the environment that would help address the most pressing knowledge gaps over the next decade. To expand that analysis, we developed a survey that was completed by 535 environmental scientists from 57 countries, of whom 49% identified environmental or analytical chemistry as their primary disciplinary background. They ranked the 22 original research questions and submitted 171 additional candidate research questions they felt were also of high priority. Of the original questions, the 3 perceived to be of highest importance related to: 1) the effects of long-term exposure to low concentrations of PPCP mixtures on nontarget organisms, 2) effluent treatment methods that can reduce the effects of PPCPs in the environment while not increasing the toxicity of whole effluents, and 3) the assessment of the environmental risks of metabolites and environmental transformation products of PPCPs. A question regarding the role of cultural perspectives in PPCP risk assessment was ranked as the lowest priority. There were significant differences in research orientation between scientists who completed English and Chinese language versions of the survey. We found that the Chinese respondents were strongly orientated to issues of managing risk profiles, effluent treatment, residue bioavailability, and regional assessment. Among English language respondents, further differences in research orientation were associated with respondents' level of consistency when ranking the survey's 15 comparisons. There was increasing emphasis on the role of various other stressors relative to PPCPs and on risk prioritization as internal decision making consistency increased. Respondents' consistency in their ranking choices was significantly and positively correlated with SETAC membership, authors' number of publications, and longer survey completion times. Our research highlighted international scientists' research priorities and should help inform decisions about the type of hazard and risk-based research needed to best inform decisions regarding PPCPs in the environment. Disciplinary training of a scientist or engineer appears to strongly influence preferences for research priorities to understand PPCPs in the environment. Selection of participants and the depth and breadth of research prioritization efforts thus have potential effects on the outcomes of research prioritization exercises. Further elucidation of how patterns of research priority vary between academic and government scientists and between scientists and other government and stakeholders would be useful in the future and provide information that helps focus scientific effort on socially relevant challenges relating to PPCPs in the environment. It also suggests the potential for future collaborative research between industry, government, and academia on environmental contaminants beyond PPCPs. Integr Environ Assess Manag 2014;10:576-587. (c) 2014 SETAC
Key Points To help fill a gap between the data generated by scientists and information required by society, we surveyed 535 environmental scientists from 57 different countries regarding their research priorities relating to PPCPs in the environment. Each survey respondent ranked 22 research questions, drawn from Boxall et al.'s recent question identification exercise, that could provide scientific evidence needed to inform regulatory and policy responses that address potential risks arising from PPCPs in the environment The single most important research question for respondents, in aggregate, related to the effects of long-term exposure to low concentrations of PPCP mixtures on nontarget organisms, but the aggregate ranking masked significant heterogeneity in research orientation among respondents Our results, which identified research priorities among active scientists, should help inform decisions about the type of research needed to best inform decisions regarding PPCPs in the environment and could assist funding agencies to prioritize resource allocation.
C1 [Rudd, Murray A.; Boxall, Alistair B. A.] Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
[Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN USA.
[Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA.
RP Rudd, MA (reprint author), Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
EM murray.rudd@york.ac.uk
RI Guenat, Heather/H-6528-2014; Brooks, Bryan/B-2612-2010
OI Brooks, Bryan/0000-0002-6277-9852
NR 36
TC 23
Z9 23
U1 12
U2 98
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD OCT
PY 2014
VL 10
IS 4
BP 576
EP 587
DI 10.1002/ieam.1551
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AQ2KZ
UT WOS:000342616200014
PM 24954797
ER
PT J
AU Haugland, RA
Siefring, SD
Varma, M
Dufour, AP
Brenner, KP
Wade, TJ
Sams, E
Cochran, S
Braun, S
Sivaganensan, M
AF Haugland, Richard A.
Siefring, Shawn D.
Varma, Manju
Dufour, Alfred P.
Brenner, Kristen P.
Wade, Timothy J.
Sams, Elizabeth
Cochran, Stacey
Braun, Steve
Sivaganensan, Mano
TI Standardization of enterococci density estimates by EPA qPCR methods and
comparison of beach action value exceedances in river waters with
culture methods
SO JOURNAL OF MICROBIOLOGICAL METHODS
LA English
DT Article
DE Enterococcus; qPCR; Recreational water quality criteria; EPA methods
ID POLYMERASE-CHAIN-REACTION; RAPIDLY MEASURED INDICATORS; QUANTITATIVE
PCR; DEMONSTRATION PROJECT; MARINE BEACHES; QUALITY; QUANTIFICATION;
SAMPLES; BACTERIA; ILLNESS
AB The U.S. EPA has published recommendations for calibrator cell equivalent (CCE) densities of enterococci in recreational waters determined by a qPCR method in its 2012 recreational water quality criteria (RWQC). The CCE quantification unit stems from the calibration model used to estimate enterococci densities in recreational beach waters in the EPA National Epidemiological and Environmental Assessment of Recreational (NEEAR) Water Study and directly informed the derivation of the RWQC recommendations. Recent studies have demonstrated that CCE estimates from the method can vary when using different cultured Enterococcus cell preparations in calibrator samples. These differences have been attributed to differences in the quantities of targeted gene copies (target sequences) that are recovered per nominal calibrator cell by DNA extraction. Standardization of results from the calibration model will require the estimation of target sequence recoveries from the calibrator and water samples. In addition, comparisons of water sample results with the RWQC values will require a knowledge of target sequence recoveries from the NEEAR study calibrator samples. In this study recoveries of target sequences and the mean target sequence/cell ratio for the NEEAR study calibrator samples were retrospectively estimated with a corroborated standard curve. A modification of the calibration model was then used to estimate enterococci target sequence quantities in water samples from eight midwestem U.S. rivers. CCE estimates were obtained by dividing these target sequence quantities by the mean NEEAR study target sequence/cell ratio. This target sequence-based quantification approach resulted in a high degree of agreement in beach action decisions (determinations of whether bacterial fecal indicator densities are above or below RWQC-recommended values) from CCE results of the qPCR method and from culture dependent enumeration of both enterococci and Eschericia coil in the corresponding water samples. Published by Elsevier B.V.
C1 [Haugland, Richard A.; Siefring, Shawn D.; Varma, Manju; Dufour, Alfred P.; Brenner, Kristen P.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Wade, Timothy J.; Sams, Elizabeth] US EPA, Off Res & Dev, Natl Hlth Effects & Environm Effects Res Lab, Chapel Hill, NC USA.
[Cochran, Stacey; Braun, Steve] Ohio River Valley Water Sanit Commiss, Cincinnati, OH USA.
[Sivaganensan, Mano] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Haugland, RA (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
EM haugland.rich@epa.gov
NR 40
TC 6
Z9 6
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-7012
EI 1872-8359
J9 J MICROBIOL METH
JI J. Microbiol. Methods
PD OCT
PY 2014
VL 105
BP 59
EP 66
DI 10.1016/j.mimet.2014.07.007
PG 8
WC Biochemical Research Methods; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA AQ5WO
UT WOS:000342879500010
PM 25038459
ER
PT J
AU Davis, MJ
Janke, R
Phillips, CA
AF Davis, Michael J.
Janke, Robert
Phillips, Cynthia A.
TI Robustness of Designs for Drinking Water Contamination Warning Systems
under Uncertain Conditions
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT
LA English
DT Article
DE Water distribution systems; Optimization; Simulation; Water quality;
Drinking water; Public health
ID SENSOR PLACEMENT; NETWORKS; OPTIMIZATION; STATIONS; SECURITY; LAYOUT;
MODEL
AB Contamination warning systems (CWSs) for drinking water distribution systems (WDSs) are used to reduce the potential adverse effects of intentional or accidental WDS contamination. They are designed on the basis of possible contamination events but often address only a narrow range in event conditions. The influence on their performance of conditions different from those assumed in the design generally is not considered. Using results from simulations done with network models for 11 actual WDSs, it is shown here that CWS performance for high-consequence events can degrade substantially (by an order of magnitude) when conditions such as contaminant toxicity and injection time differ from those used in the design. Generally, increasing the number of sensors does not reduce this sensitivity to changed conditions. The significance of uncertain conditions varies substantially among WDSs. As a consequence of performance changes that occur when conditions change, mean-case designs generally outperform worst-case designs when the objective is to minimize worst-case adverse effects over a range of conditions. The results of this work can be used to implement more robust designs for CWSs, while reducing computational requirements. (C) 2014 American Society of Civil Engineers.
C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne, IL 60439 USA.
[Janke, Robert] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
[Phillips, Cynthia A.] Sandia Natl Labs, Albuquerque, NM 87185 USA.
RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM mike_davis@anl.gov; janke.robert@epa.gov; caphill@sandia.gov
FU U.S. Environmental Protection Agency's (EPA) Office of Research and
Development; EPA under U.S. Department of Energy [DE-AC02-06CH11357]
FX The U.S. Environmental Protection Agency's (EPA) Office of Research and
Development funded, managed, and participated in the research described
here under an interagency agreement. The views expressed in this paper
are those of the authors and do no necessarily reflect the views or
policies of EPA. Work at Argonne National Laboratory was sponsored by
the EPA under interagency agreement through U.S. Department of Energy
Contract DE-AC02-06CH11357. Because the information is confidential, the
authors cannot disclose the identity of the WDSs studied in this paper
or any information that could be used to identify them.
NR 27
TC 2
Z9 2
U1 0
U2 12
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
EI 1943-5452
J9 J WATER RES PLAN MAN
JI J. Water Resour. Plan. Manage.-ASCE
PD OCT
PY 2014
VL 140
IS 10
AR 04014028
DI 10.1061/(ASCE)WR.1943-5452.0000408
PG 11
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA AQ5HP
UT WOS:000342838900005
ER
PT J
AU Beverly, BEJ
Lambright, CS
Furr, JR
Sampson, H
Wilson, VS
McIntyre, BS
Foster, PMD
Travlos, G
Gray, LE
AF Beverly, Brandiese E. J.
Lambright, Christy S.
Furr, Johnathan R.
Sampson, Hunter
Wilson, Vickie S.
McIntyre, Barry S.
Foster, Paul M. D.
Travlos, Gregory
Gray, L. Earl, Jr.
TI Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone
Production and Exhibit Additive Effects on Testicular Testosterone and
Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE simvastatin; phthalates; steroidogenesis; cholesterol; sexual
differentiation
ID N-BUTYL PHTHALATE; COA REDUCTASE INHIBITOR; COENZYME-A REDUCTASE;
IN-UTERO EXPOSURE; SEXUAL-DIFFERENTIATION; REPRODUCTIVE DEVELOPMENT;
DI(N-BUTYL) PHTHALATE; LEYDIG-CELLS; DEVELOPMENTAL TOXICITY;
STEROIDOGENIC ENZYMES
AB Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lowering fetal androgen and Insl3 hormone levels. Simvastatin (SMV) is a cholesterol-lowering drug that directly inhibits HMG-CoA reductase. SMV may also disrupt steroid biosynthesis, but through a different mode of action (MOA) than the PEs. As cholesterol is a precursor of steroid hormone biosynthesis, we hypothesized that in utero exposure to SMV during the critical period of sex differentiation would lower fetal testicular testosterone (T) production without affecting genes involved in cholesterol and androgen synthesis and transport. Secondly, we hypothesized that a mixture of SMV and a PE, which may have different MOAs, would reduce testosterone levels in an additive manner. Pregnant Sprague Dawley rats were dosed orally with SMV, dipentyl phthalate (DPeP), or SMV plus DPeP from gestational days 14-18, and fetuses were evaluated on GD18. On GD18, SMV lowered fetal T production and serum triglycerides, low density lipoprotein, high density lipoprotein, and total cholesterol levels, and downregulated two genes in the fetal testis that were different from those altered by PEs. When SMV and DPeP were administered as a mixture, fetal T production was significantly reduced in an additive manner, thus demonstrating that a mixture of chemicals can induce additive effects on fetal T production even though they display different MOAs.
C1 [Beverly, Brandiese E. J.; Lambright, Christy S.; Furr, Johnathan R.; Sampson, Hunter; Wilson, Vickie S.; Gray, L. Earl, Jr.] US EPA, Reprod Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Beverly, Brandiese E. J.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA.
[McIntyre, Barry S.; Foster, Paul M. D.; Travlos, Gregory] NIEHS, Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA.
RP Gray, LE (reprint author), MD 72,TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM emgray@mindspring.com
OI Wilson, Vickie/0000-0003-1661-8481
FU US Environmental Protection Agency; National Institute of Environmental
Health Sciences at the National Institutes of Health [IA]
[RW-75-92285501]; Oak Ridge Institute for Science and Education
fellowship
FX This work was supported in part by an interagency agreement with the US
Environmental Protection Agency and the National Institute of
Environmental Health Sciences at the National Institutes of Health [IA
no. RW-75-92285501]. B.E.J.B. was funded through an Oak Ridge Institute
for Science and Education fellowship.
NR 44
TC 3
Z9 3
U1 2
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD OCT
PY 2014
VL 141
IS 2
BP 524
EP 537
DI 10.1093/toxsci/kfu149
PG 14
WC Toxicology
SC Toxicology
GA AQ8BD
UT WOS:000343045100022
PM 25055962
ER
PT J
AU Judd, LL
Schettler, PJ
Brown, ES
Wolkowitz, OM
Sternberg, EM
Bender, BG
Bulloch, K
Cidlowski, JA
de Kloet, ER
Fardet, L
Joels, M
Leung, DYM
McEwen, BS
Roozendaal, B
Van Rossum, EFC
Ahn, J
Brown, DW
Plitt, A
Singh, G
AF Judd, Lewis L.
Schettler, Pamela J.
Brown, E. Sherwood
Wolkowitz, Owen M.
Sternberg, Esther M.
Bender, Bruce G.
Bulloch, Karen
Cidlowski, John A.
de Kloet, E. Ronald
Fardet, Laurence
Joels, Marian
Leung, Donald Y. M.
McEwen, Bruce S.
Roozendaal, Benno
Van Rossum, Elisabeth F. C.
Ahn, Junyoung
Brown, David W.
Plitt, Aaron
Singh, Gagandeep
TI Adverse Consequences of Glucocorticoid Medication: Psychological,
Cognitive, and Behavioral Effects
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID RECEIVING CORTICOSTEROID-THERAPY; BDNF MESSENGER-RNA; DECLARATIVE
MEMORY; PSYCHOSOCIAL STRESS; MULTIPLE-SCLEROSIS; INDUCED IMPAIRMENT;
STEROID DEMENTIA; CORTISOL-LEVELS; WORKING-MEMORY; BRAIN ACTIVITY
AB Glucocorticoids are the most commonly prescribed anti-inflammatory/immunosuppressant medications worldwide. This article highlights the risk of clinically significant and sometimes severe psychological, cognitive, and behavioral disturbances that may be associated with glucocorticoid use, as well as ways to prevent and treat these disturbances. An illustrative case vignette is presented describing a patient's experience of cycles of manic-like behavior and depression while on high-dosage prednisone, with long-term cognitive disorganization, vulnerability to stress, and personality changes. Severe neuropsychiatric consequences (including suicide, suicide attempt, psychosis, mania, depression, panic disorder, and delirium, confusion, or disorientation) have been reported to occur in 15.7 per 100 person-years at risk for all glucocorticoid courses, and 22.2 per 100 person-years at risk for first courses. The majority of patients experience less severe but distressing and possibly persistent changes in mood, cognition, memory, or behavior during glucocorticoid treatment or withdrawal. Although prediction of such effects is difficult, risks vary with age, gender, dosage, prior psychiatric history, and several biological markers. Key mechanisms thought to underlie these risk factors are briefly described. Recommendations are given for identifying individual risk factors and for monitoring and managing adverse neuropsychiatric effects of glucocorticoids.
C1 [Judd, Lewis L.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
Univ Arizona, Coll Med, Arizona Ctr Integrat Med, Tucson, AZ USA.
Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO USA.
Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USA.
Rockefeller Univ, Lab Cell Physiol & Immunol, New York, NY 10021 USA.
Natl Inst Environm Hlth Sci, Lab Signal Transduct, Res Triangle Pk, NC USA.
Leiden Univ, Leiden Amsterdam Ctr Drug Res, Leiden, Netherlands.
Univ Paris 06, Hop St Antoine, AP HP, Dept Internal Med, Paris, France.
Univ Med Ctr, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
Natl Jewish Med & Res Ctr, Div Pediat Allergy & Immunol, Denver, CO USA.
Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Anat Sect, Groningen, Netherlands.
Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
RP Judd, LL (reprint author), Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
EM ljudd@ucsd.edu
RI Roozendaal, Benno/B-8403-2013; de Kloet, Edo Ronald/H-3278-2011; Joels,
Marian/P-6415-2016
FU Diana Padelford Binkley Foundation; Sunovion; Forest; Corcept
Pharmaceuticals; Netherlands Organization for Scientific Research;
Netherlands Brain Foundation
FX All but the last four authors are members of the Workgroup on
Neuropsychiatric Sequelae of Glucocorticoid Treatment, which is funded
by the Diana Padelford Binkley Foundation. Dr. Schettler received
payment from the Diana Padelford Binkley Foundation for work related to
the Workgroup and to this study. Dr. Brown has received research grants
from Sunovion and Forest. Dr. de Kloet has served as a scientific
adviser for Corcept Therapeutics and DynaCorts Therapeutics and owns
stock in Corcept Therapeutics. Dr. Joels has received a research grant
from Corcept Pharmaceuticals and research support from the Netherlands
Organization for Scientific Research. Dr. van Rossum is supported by the
Netherlands Brain Foundation. The other authors report no financial
relationships with commercial interests.
NR 79
TC 26
Z9 26
U1 6
U2 26
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD OCT
PY 2014
VL 171
IS 10
BP 1045
EP 1051
DI 10.1176/appi.ajp.2014.13091264
PG 7
WC Psychiatry
SC Psychiatry
GA AQ3SM
UT WOS:000342713800007
PM 25272344
ER
PT J
AU Russom, CL
LaLone, CA
Villeneuve, DL
Ankley, GT
AF Russom, Christine L.
LaLone, Carlie A.
Villeneuve, Daniel L.
Ankley, Gerald T.
TI DEVELOPMENT OF AN ADVERSE OUTCOME PATHWAY FOR ACETYLCHOLINESTERASE
INHIBITION LEADING TO ACUTE MORTALITY
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Review
DE Acetylcholinesterase inhibition; Adverse outcome pathway; Ecotoxicology;
Species sensitivity
ID RECOVERY FOLLOWING ACUTE; ACUTE TOXICITY; ANTICHOLINESTERASE ACTIVITY;
CHOLINESTERASE INHIBITION; CHLORPYRIFOS EXPOSURE; IPCS FRAMEWORK;
FATHEAD MINNOW; DAPHNIA-MAGNA; RAT STRIATUM; ORGANOPHOSPHORUS
AB Adverse outcome pathways (AOPs) are designed to describe linkages of key events within a biological pathway that result in an adverse outcome associated with chemical perturbation of a well-defined molecular initiating event. Risk assessors have traditionally relied on data from apical endpoints (e.g., mortality, growth, reproduction) to derive benchmark values for use in determining the potential adverse impacts of chemicals. One goal in building reliable and well-characterized AOPs is to identify relevant in vitro assays and/or in vivo biomarkers that could be used in screening the potential hazard of substances, thereby reducing costs and increasing the number of chemicals that can be evaluated in a timely fashion. The purpose of this review article is to build an AOP for substances with a molecular initiating event of acetylcholinesterase inhibition leading to acute mortality following guidance developed by the Organisation for Economic Cooperation and Development. In contrast to most other AOPs developed to date, in which coverage is for a relatively limited taxonomic group or life stage, this AOP is applicable to a wide range of species at multiple life stages. Furthermore, while development of most AOPs has relied on data for a few model chemicals, the AOP described in the present review captures information from a large number of studies with a diversity of organophosphate and carbamate insecticides. Environ Toxicol Chem 2014;33:2157-2169. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
C1 [Russom, Christine L.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[LaLone, Carlie A.] Univ Minnesota, Water Resources Ctr, Coll Food Agr & Nat Resource Sci, St Paul, MN 55108 USA.
RP Ankley, GT (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA.
EM ankley.gerald@epa.gov
NR 91
TC 16
Z9 16
U1 6
U2 58
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD OCT
PY 2014
VL 33
IS 10
BP 2157
EP 2169
DI 10.1002/etc.2662
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AQ2LZ
UT WOS:000342619100001
PM 24922588
ER
PT J
AU Pfleeger, T
Blakeley-Smith, M
Lee, EH
King, G
Plocher, M
Olszyk, D
AF Pfleeger, Thomas
Blakeley-Smith, Matthew
Lee, E. Henry
King, George
Plocher, Milton
Olszyk, David
TI EFFECTS OF SINGLE AND MULTIPLE APPLICATIONS OF GLYPHOSATE OR
AMINOPYRALID ON SIMPLE CONSTRUCTED PLANT COMMUNITIES
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Glyphosate; Aminopyralid; Plant communities
ID HERBICIDE SPRAY DRIFT; SULFONYLUREA HERBICIDES; ECOSYSTEM SERVICES;
NONTARGET PLANTS; FIELD; BIODIVERSITY; 2,4-D; VEGETATION; FERTILIZER;
IMPACTS
AB To determine effects of multiple applications of herbicides on small constructed plant communities, Prunella vulgaris L.var. lanceolata Fern, Festuca roemeri (Pavlick) Alexeev, Clarkia amoena (Lehm.) Nels., and Cynosurus echinatus L. were grown together in small field plots. Plants were treated with glyphosate at target concentrations of 0x, 0.01x, 0.1x, and 0.2x a field application rate (FAR) of 1122gha(-1) active ingredient (a.i.) for 3 yr in 1 location, and for 2 yr in a second location. Plants also were treated with aminopyralid at 0x, 0.037x, 0.136x, and 0.5x FAR of 123gha(-1) a.i. for 2 yr in 2 locations. Plants received 1, 2, or 3 applications of each herbicide each year. Species and community responses depended on herbicide concentration and number of applications. With glyphosate, plant volume (modified formula for a cone) tended to decrease for all species (especiallyC. echinatus), and the decreases generally became larger with more applications. Plant communities exposed to the 2 greatest concentrations initially differed from controls but then appeared to recover. With aminopyralid, C. amoena was essentially eliminated from the communities, especially at the 2 greatest FARs, whereas the other 3 species tended to have significant increases in volume, especially at the 2 smallest FARs. With aminopyralid, increasing numbers of applications produced variable results, and the plant community volume never tended to recover. Environ Toxicol Chem 2014;33:2368-2378. Published 2014 Wiley Periodicals Inc., on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.
C1 [Pfleeger, Thomas; Lee, E. Henry; Olszyk, David] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Blakeley-Smith, Matthew] Greenbelt Land Trust, Corvallis, OR USA.
[King, George; Plocher, Milton] Dynamac, Corvallis, OR USA.
RP Olszyk, D (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
EM olszyk.david@epa.gov
FU US Environmental Protection Agency [68-D-01-005, EP-D-06-013,
EP-D-11-027]; SRA, International; [GS-35F-4594G TO 1525]
FX The information in this document has been funded in part by the US
Environmental Protection Agency under contract numbers 68-D-01-005,
EP-D-06-013, and EP-D-11-027 to Dynamac Corporation and contract number
GS-35F-4594G TO 1525 with SRA, International. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory's Western Ecology Division and approved for publication.
Approval does not signify that the contents reflect the views of the
Agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 40
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U1 2
U2 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD OCT
PY 2014
VL 33
IS 10
BP 2368
EP 2378
DI 10.1002/etc.2686
PG 11
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AQ2LZ
UT WOS:000342619100025
PM 25043825
ER
PT J
AU Summers, JK
Smith, LM
AF Summers, J. K.
Smith, L. M.
TI The Role of Social and Intergenerational Equity in Making Changes in
Human Well-Being Sustainable
SO AMBIO
LA English
DT Review
DE Well-being; Sustainability; Social equity; Environmental justice;
Intergenerational equity
ID ENVIRONMENTAL JUSTICE; CLIMATE-CHANGE; INNER-CITY; EQUALITY; ATTENTION;
SERVICES; DISASTER; WELFARE; RACE
AB A sustainable world is one in which human needs are met equitably and without sacrificing the ability of future generations to meet their needs. Human well-being is described by four primary elements-basic human needs, economic needs, environmental needs, and subjective well-being. These elements can interact in a myriad of ways to influence overall well-being. What makes changes in human well-being sustainable for a population or a nation? Two major interactional concepts can push changes in human well-being toward a sustainable state in space and time-social equity and intergenerational equity. The concept of social equity distributes well-being over space, ensuring the fair treatment of all members of society promoting spatial sustainability of a well-being decision. The concept of intergenerational equity distributes well-being through time, ensuring the well-being of present and future generations of a population or nation, promoting temporal sustainability of a well-being decision. The roles of social and intergenerational equity in terms of their influence on human well-being are examined with a focus on more sustainable decision-making.
C1 [Summers, J. K.; Smith, L. M.] US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Gulf Breeze, FL 32561 USA.
RP Summers, JK (reprint author), US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM summers.kevin@epa.gov
FU US Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the US Environmental Protection Agency. It has been subjected to review
by the National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 86
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0044-7447
EI 1654-7209
J9 AMBIO
JI Ambio
PD OCT
PY 2014
VL 43
IS 6
BP 718
EP 728
DI 10.1007/s13280-013-0483-6
PG 11
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP6RN
UT WOS:000342205400002
PM 24402649
ER
PT J
AU Baker, KR
Kelly, JT
AF Baker, Kirk R.
Kelly, James T.
TI Single source impacts estimated with photochemical model source
sensitivity and apportionment approaches
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Photochemical model; Plume; Ozone; PM; Single source; Source
apportionment
ID AIR-QUALITY MODELS; POWER-PLANT PLUME; OZONE; SULFATE; IMPLEMENTATION;
PREDICTIONS; PM2.5
AB Some sources may need to estimate ozone and secondarily formed PM2.5 as part of the permit application process under the Clean Air Act New Source Review program. Photochemical grid models represent state-of-the-science gas- and particle-phase chemistry and provide a realistic chemical and physical environment for assessing changes in air quality resulting from changes in emissions. When using these tools for single source impact assessments, it is important to differentiate a single source impact from other emissions sources and to understand how well contemporary grid model applications capture near-source transport and chemistry. Here for the first time, both source apportionment and source sensitivity approaches (brute-force changes and high-order direct decoupled method) are used in a photochemical grid model to isolate impacts of a specific facility. These single source impacts are compared with in-plume measurements made as part of a well-characterized 1999 TVA Cumberland aircraft plume transect field study. The techniques were able to isolate the impacts of the TVA plume in a manner consistent with observations. The model predicted in-plume concentrations well when the observations were averaged to the grid scale, although peak concentrations of primary pollutants were generally underestimated near the source, possibly due to dilution in the 4-km grid cell. Published by Elsevier Ltd.
C1 [Baker, Kirk R.; Kelly, James T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Baker, KR (reprint author), US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM baker.kirk@epa.gov
RI Kelly, James/F-8135-2010
OI Kelly, James/0000-0001-6574-5714
NR 34
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U1 1
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD OCT
PY 2014
VL 96
BP 266
EP 274
DI 10.1016/j.atmosenv.2014.07.042
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AP7HF
UT WOS:000342247700028
ER
PT J
AU Fiore, AM
Oberman, JT
Lin, MY
Zhang, L
Clifton, OE
Jacob, DJ
Naik, V
Horowitz, LW
Pinto, JP
Milly, GP
AF Fiore, A. M.
Oberman, J. T.
Lin, M. Y.
Zhang, L.
Clifton, O. E.
Jacob, D. J.
Naik, V.
Horowitz, L. W.
Pinto, J. P.
Milly, G. P.
TI Estimating North American background ozone in U.S. surface air with two
independent global models: Variability, uncertainties, and
recommendations
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Surface ozone; Background ozone; Air pollution; Air quality; Exceptional
events
ID BIOMASS BURNING EMISSIONS; EASTERN UNITED-STATES; TROPOSPHERIC OZONE;
ATMOSPHERIC COMPOSITION; POLLUTION INFLUENCES; CHEMISTRY; POLICY;
QUALITY; TRENDS; GASES
AB Accurate estimates for North American background (NAB) ozone (O-3) in surface air over the United States are needed for setting and implementing an attainable national O-3 standard. These estimates rely on simulations with atmospheric chemistry-transport models that set North American anthropogenic emissions to zero, and to date have relied heavily on one global model. We examine NAB estimates for spring and summer 2006 with two independent global models (GEOS-Chem and GFDL AM3). We evaluate the base simulations, which include North American anthropogenic emissions, with mid-tropospheric O-3 retrieved from space and ground-level O-3 measurements. The models often bracket the observed values, implying value in developing a multi-model approach to estimate NAB O-3. Consistent with earlier studies, the models robustly simulate the largest nation-wide NAB levels at high-altitude western U.S. sites (seasonal average maximum daily 8-h values of similar to 40-50 ppb in spring and similar to 25 -40 ppb in summer) where it correlates with observed O-3. At these sites, a 27-year GFDL AM3 simulation simulates observed O-3 events above 60 ppb and indicates that year-to-year variations in NAB O-3 influence their annual frequency (with NAB contributing 50-60 ppb or more during individual events). During summer over the eastern United States (EUS), when photochemical production from regional anthropogenic emissions peaks, NAB is largely uncorrelated with observed values and it is lower than at high-altitude sites (average values of similar to 20-30 ppb). Four processes contribute substantially to model differences in specific regions and seasons: lightning NOx biogenic isoprene emissions and chemistry, wildfires, and stratosphere-to-troposphere transport. Differences in the representations of these processes within the GFDL AM3 and GEOS-Chem models contribute more to uncertainty in NAB estimates, particularly in spring when NAB is highest, than the choice of horizontal resolution within a single model (GEOS-Chem). We propose that future efforts seek to constrain these processes with targeted analysis of multi-model simulations evaluated with observations of O-3 and related species from multiple platforms, and thereby reduce the error on NAB estimates needed for air quality planning. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Fiore, A. M.; Clifton, O. E.] Columbia Univ, Dept Earth & Environm Sci, Palisades, NY 10964 USA.
[Milly, G. P.] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA.
[Oberman, J. T.] Univ Wisconsin, Nelson Inst Ctr Sustainabil & Global Environm SAG, Madison, WI USA.
[Lin, M. Y.; Horowitz, L. W.] Princeton Univ, NOAA Geophys Fluid Dynam Lab & Atmospher & Ocean, Princeton, NJ 08544 USA.
[Zhang, L.; Jacob, D. J.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[Zhang, L.] Peking Univ, Sch Phys, Dept Atmospher & Ocean Sci, Beijing, Peoples R China.
[Zhang, L.] Peking Univ, Sch Phys, Lab Climate & Ocean Atmosphere Studies, Beijing, Peoples R China.
[Naik, V.] UCAR, NOAA Geophys Fluid Dynam Lab, Princeton, NJ USA.
[Pinto, J. P.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Fiore, AM (reprint author), Columbia Univ, Dept Earth & Environm Sci, 61 Route 9W, Palisades, NY 10964 USA.
EM amfiore@ldeo.columbia.edu; oberman.wisc@gmail.com; meiyun.lin@noaa.gov;
zhanglg@pku.edu.cn; oclifton@ldeo.columbia.edu; djacob@fas.harvard.edu;
Vaishali.Naik@noaa.gov; larry.horowitz@noaa.gov; Pinto.joseph@epa.gov;
gpm2109@columbia.edu
RI Chem, GEOS/C-5595-2014; 杨, 宇栋/F-6250-2012; Horowitz, Larry/D-8048-2014;
Naik, Vaishali/A-4938-2013; Zhang, Lin/A-6729-2008
OI Lin, Meiyun/0000-0003-3852-3491; Horowitz, Larry/0000-0002-5886-3314;
Naik, Vaishali/0000-0002-2254-1700; Zhang, Lin/0000-0003-2383-8431
FU NASA Air Quality Applied Sciences Team [NNX12AF15G, NNX11AH93G]; NOAA
Ernest F. Hollings Scholarship program
FX We acknowledge support from the NASA Air Quality Applied Sciences Team
(NNX12AF15G to AMF; NNX11AH93G to DJJ), and the NOAA Ernest F. Hollings
Scholarship program (JTO). We are grateful to P. Dolwick (U.S. EPA) for
useful discussions and comments, and suggestions from anonymous review.
The information in this article has been subjected to review by the
National Center for Environmental Assessment, U.S. Environmental
Protection Agency, and approved for publication. The views expressed in
this manuscript are those of the authors and do not necessarily
represent the views or policies of the U.S. Environmental Protection
Agency.
NR 65
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD OCT
PY 2014
VL 96
BP 284
EP 300
DI 10.1016/j.atmosenv.2014.07.045
PG 17
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AP7HF
UT WOS:000342247700030
ER
PT J
AU Bansal, R
Tighe, D
Danai, A
Rawn, DFK
Gaertner, DW
Arnold, DL
Gilbert, ME
Zoeller, RT
AF Bansal, Ruby
Tighe, Daniel
Danai, Amin
Rawn, Dorothea F. K.
Gaertner, Dean W.
Arnold, Doug L.
Gilbert, Mary E.
Zoeller, R. Thomas
TI Polybrominated Diphenyl Ether (DE-71) Interferes With Thyroid Hormone
Action Independent of Effects on Circulating Levels of Thyroid Hormone
in Male Rats
SO ENDOCRINOLOGY
LA English
DT Article
ID PROPYLTHIOURACIL PTU PHARMACOLOGY; POLYCHLORINATED BIPHENYL PCB;
MICROSOMAL-ENZYME INDUCERS; EXPOSURE; PBDE; PITUITARY; BRAIN;
DISRUPTION; THYROXINE; BINDING
AB Polybrominated diphenyl ethers (PBDEs) are routinely found in human tissues including cord blood and breast milk. PBDEs may interfere with thyroid hormone (TH) during development, which could produce neurobehavioral deficits. An assumption in experimental and epidemiological studies is that PBDE effects on serum TH levels will reflect PBDE effects on TH action in tissues. To test whether this assumption is correct, we performed the following experiments. First, five concentrations of diphenyl ether (0-30 mg/kg) were fed daily to pregnant rats to postnatal day 21. PBDEs were measured in dam liver and heart to estimate internal dose. The results were compared with a separate study in which four concentrations of propylthiouracil (PTU; 0, 1, 2, and 3 ppm) was provided to pregnant rats in drinking water for the same duration as for diphenyl ether. PBDE exposure reduced serum T-4 similar in magnitude to PTU, but serum TSH was not elevated by PBDE. PBDE treatment did not affect the expression of TH response genes in the liver or heart as did PTU treatment. PTU treatment reduced T-4 in liver and heart, but PBDE treatment reduced T-4 only in the heart. Tissue PBDEs were in the micrograms per gram lipid range, only slightly higher than observed in human fetal tissues. Thus, PBDE exposure reduces serum T-4 but does not produce effects on tissues typical of low TH produced by PTU, demonstrating that the effects of chemical exposure on serum T-4 levels may not always be a faithful proxy measure of chemical effects on the ability of thyroid hormone to regulate development and adult physiology.
C1 [Bansal, Ruby; Tighe, Daniel; Danai, Amin; Zoeller, R. Thomas] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA.
[Zoeller, R. Thomas] Univ Massachusetts, Mol & Cellular Biol Program, Amherst, MA 01003 USA.
[Rawn, Dorothea F. K.; Gaertner, Dean W.; Arnold, Doug L.] Hlth Canada, Hlth Prod & Food Branch, Food Directorate, Bur Chem Safety, Ottawa, ON K1A 0K9, Canada.
[Gilbert, Mary E.] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
RP Zoeller, RT (reprint author), Univ Massachusetts, Dept Biol, Morrill Sci Bldg,611 North Pleasant St, Amherst, MA 01003 USA.
EM tzoeller@bio.umass.edu
FU US Environmental Protection Agency Science [RD-3213701]; National
Institute of Environmental Health Sciences [ES10026]
FX This work was supported in part by US Environmental Protection Agency
Science to Achieve Results Grants RD-3213701 (to R.T.Z.) and ES10026
from the National Institute of Environmental Health Sciences (to
R.T.Z.).
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PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT
PY 2014
VL 155
IS 10
BP 4104
EP 4112
DI 10.1210/en.2014-1154
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AP8QX
UT WOS:000342345000037
PM 25060363
ER
PT J
AU Pond, GJ
Passmore, ME
Pointon, ND
Felbinger, JK
Walker, CA
Krock, KJG
Fulton, JB
Nash, WL
AF Pond, Gregory J.
Passmore, Margaret E.
Pointon, Nancy D.
Felbinger, John K.
Walker, Craig A.
Krock, Kelly J. G.
Fulton, Jennifer B.
Nash, Whitney L.
TI Long-Term Impacts on Macroinvertebrates Downstream of Reclaimed
Mountaintop Mining Valley Fills in Central Appalachia
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Bioassessment; Mountaintop mining; Valley fills; Reclamation;
Appalachian mountains; Headwater streams; Specific conductance
ID HEADWATER STREAMS; IONIC-STRENGTH; QUALITY; MINE; BIODIVERSITY;
COMMUNITIES; ECOSYSTEMS; WATERSHEDS; RECOVERY; KENTUCKY
AB Recent studies have documented adverse effects to biological communities downstream of mountaintop coal mining and valley fills (VF), but few data exist on the longevity of these impacts. We sampled 15 headwater streams with VFs reclaimed 11-33 years prior to 2011 and sampled seven local reference sites that had no VFs. We collected chemical, habitat, and benthic macroinvertebrate data in April 2011; additional chemical samples were collected in September 2011. To assess ecological condition, we compared VF and reference abiotic and biotic data using: (1) ordination to detect multivariate differences, (2) benthic indices (a multimetric index and an observed/expected predictive model) calibrated to state reference conditions to detect impairment, and (3) correlation and regression analysis to detect relationships between biotic and abiotic data. Although VF sites had good instream habitat, nearly 90 % of these streams exhibited biological impairment. VF sites with higher index scores were co-located near unaffected tributaries; we suggest that these tributaries were sources of sensitive taxa as drifting colonists. There were clear losses of expected taxa across most VF sites and two functional feeding groups (% scrapers and %shredders) were significantly altered. Percent VF and forested area were related to biological quality but varied more than individual ions and specific conductance. Within the subset of VF sites, other descriptors (e.g., VF age, site distance from VF, the presence of impoundments, % forest) had no detectable relationships with biological condition. Although these VFs were constructed pursuant to permits and regulatory programs that have as their stated goals that (1) mined land be reclaimed and restored to its original use or a use of higher value, and (2) mining does not cause or contribute to violations of water quality standards, we found sustained ecological damage in headwaters streams draining VFs long after reclamation was completed.
C1 [Pond, Gregory J.; Passmore, Margaret E.; Krock, Kelly J. G.; Fulton, Jennifer B.] US EPA, Environm Assessment & Innovat Div, Off Monitoring & Assessment Reg 3, Wheeling, WV 26003 USA.
[Pointon, Nancy D.; Felbinger, John K.; Walker, Craig A.] Three Pkwy Ctr, Off Surface Min, Appalachian Reg Off, Pittsburgh, PA 15220 USA.
[Nash, Whitney L.] Knoxville Field Off, Off Surface Min, Knoxville, TN 37902 USA.
RP Pond, GJ (reprint author), US EPA, Environm Assessment & Innovat Div, Off Monitoring & Assessment Reg 3, 1060 Chapline St, Wheeling, WV 26003 USA.
EM pond.greg@epa.gov
FU EPA; OSMRE
FX This research was performed jointly through cooperation between U. S.
Environmental Protection Agency (EPA) Region III and U. S. Department of
Interior's Office of Surface Mining Reclamation and Enforcement (OSMRE)
and we thank John Pomponio and John Forren (EPA-Region III) and Lois
Uranowski and Dave Hartos (OSMRE) for programmatic support to the
authors. Additional field assistance was provided by Lou Reynolds
(EPA-Region III) and Omar Beckford (OSMRE). We especially appreciate
mining inspectors from WVDEP's Logan, Oak Hill, and Philippi Offices who
assisted with site access, and Nick Schaer (WVDEP) for advice on site
selection. We also thank Tom Mastrorocco (OSMRE) for GIS assistance. An
earlier draft of the manuscript was reviewed by Ken Fritz, Brent
Johnson, and Glenn Suter (EPA-Office of Research and Development), Matt
Klasen and Rachael Novak (EPA-Office of Water), Jeff Bailey and Michael
Whitman (WVDEP), Stefania Shamet (EPA-Region III), Leah Ettema
(EPA-Region IV) and Jason Robinson (Illinois Natural History Survey). We
also thank Angus Webb (University of Melbourne) and Kyle Hartman (West
Virginia University) for thier reviews. Although this research was
supported by EPA and OSMRE, opinions are those of the authors and do not
represent official government policy.
NR 45
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD OCT
PY 2014
VL 54
IS 4
BP 919
EP 933
DI 10.1007/s00267-014-0319-6
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AP9VK
UT WOS:000342428700022
PM 24990807
ER
PT J
AU Grond, K
Ryu, H
Baker, AJ
Domingo, JWS
Buehler, DM
AF Grond, Kirsten
Ryu, Hodon
Baker, Allan J.
Domingo, Jorge W. Santo
Buehler, Deborah M.
TI Gastro-intestinal microbiota of two migratory shorebird species during
spring migration staging in Delaware Bay, USA
SO JOURNAL OF ORNITHOLOGY
LA English
DT Article
DE Gut microbiota; Shorebirds; 16S rRNA; Staging; Campylobacter
ID RIBOSOMAL-RNA GENES; CALIDRIS-CANUTUS; WILD BIRDS; PREVALENCE; DISEASE;
DIVERSITY; SEQUENCES; HEALTH; FECES; CAMPYLOBACTER
AB Migratory birds travel long distances and use diverse habitats, potentially exposing them to a broad range of microbes that could negatively affect their health and survival. Gut microbiota composition may be related to organismal health especially during periods of impaired immunity due to stress, by functioning as a reservoir for potential pathogens. We provide an insight into the composition of the gastrointestinal microbiota in migratory Red Knot (Calidris canutus) and Ruddy Turnstone (Arenaria interpres) staging in Delaware Bay, USA, by analyzing fecal bacterial communities of three individuals per species with 16S rRNA clone libraries. In the 313 bacterial sequences we analysed from Red Knots, we identified 19 bacterial classes across 29 genera, and from the 218 Ruddy Turnstone sequences, we identified 11 bacterial classes across 17 genera. In Red Knots and Ruddy Turnstones, 27 and 41 % of all sequences were closely related to Campylobacter spp., which include several human pathogens. Only 5 of the 46 genera, and 8 out of 124 operational taxonomic units were shared between species, suggesting that gut microbial community structure can be species-specific under environmentally similar conditions. Our study provides baseline information that can be used in future studies to better understand diversity and function of gut microbes, and can be expanded to investigate how gut microbiota of migratory birds affects their body condition, immune function, and demographic performance.
C1 [Grond, Kirsten; Baker, Allan J.; Buehler, Deborah M.] Royal Ontario Museum, Dept Nat Hist, Toronto, ON M5S 2C6, Canada.
[Grond, Kirsten; Baker, Allan J.; Buehler, Deborah M.] Univ Toronto, Toronto, ON M5S 3B2, Canada.
[Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Grond, K (reprint author), Kansas State Univ, Div Biol, Ackert Hall, Manhattan, KS 66506 USA.
EM kgrond@ksu.edu
FU Natural Science and Engineering Council of Canada [PDF-373488-2009];
Netherlands Organisation for Scientific Research [825.09.0190]; EPA
Office of Research and Development
FX We would like to thank Nigel A. Clark, Jacquie A. Clark (British Trust
for Ornithology) and Kevin S. Kalasz (US Fish and Wildlife Services) for
granting us permission to sample shore-birds and for providing
logistical assistance in Delaware Bay. We would also like to thank
Yvonne I. Verkuil for valuable help during both field and laboratory
work. Lastly, we thank three anonymous reviewers for their insightful
comments which notably improved our manuscript. This study was funded by
grants from the Natural Science and Engineering Council of Canada
[PDF-373488-2009] and the Netherlands Organisation for Scientific
Research (Rubicon 825.09.0190) to D. M. B. and by the EPA Office of
Research and Development. All sampling procedures were in compliance
with animal welfare laws of the USA and all permits necessary for
shipping and handling of biological samples were obtained.
NR 41
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0021-8375
EI 1439-0361
J9 J ORNITHOL
JI J. Ornithol.
PD OCT
PY 2014
VL 155
IS 4
BP 969
EP 977
DI 10.1007/s10336-014-1083-3
PG 9
WC Ornithology
SC Zoology
GA AP9PR
UT WOS:000342412200012
ER
PT J
AU Olden, K
Lin, YS
Gruber, D
Sonawane, B
AF Olden, Kenneth
Lin, Yu-Sheng
Gruber, David
Sonawane, Babasaheb
TI Epigenome: Biosensor of Cumulative Exposure to Chemical and Nonchemical
Stressors Related to Environmental Justice
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Editorial Material
ID DNA METHYLATION; ARSENIC EXPOSURE; GENE-EXPRESSION; DRINKING-WATER;
EPIGENETIC EPIDEMIOLOGY; MAMMALIAN-CELLS; BIRTH OUTCOMES; HUMAN-DISEASE;
BISPHENOL-A; CANCER
AB Understanding differential disease susceptibility requires new tools to quantify the cumulative effects of environmental stress. Evidence suggests that social, physical, and chemical stressors can influence disease through the accumulation of epigenetic modifications.
Geographically stable epigenetic alterations could identify plausible mechanisms for health disparities among the disadvantaged and poor. Relations between neighborhoodspecific epigenetic markers and disease would identify the most appropriate targets for medical and environmental intervention. Complex interactions among genes, the environment, and disease require the examination of how epigenetic changes regulate susceptibility to environmental stressors. Progress in understanding disparities in disease susceptibility may depend on assessing the cumulative effect of environmental stressors on genetic substrates.
We highlight key concepts regarding the interface between environmental stress, epigenetics, and chronic disease.
C1 [Olden, Kenneth; Lin, Yu-Sheng; Sonawane, Babasaheb] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Gruber, David] CUNY Bernard M Baruch Coll, Dept Nat Sci, New York, NY 10010 USA.
RP Olden, K (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
EM olden.kenneth@epa.gov
NR 65
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U2 16
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD OCT
PY 2014
VL 104
IS 10
BP 1816
EP 1821
DI 10.2105/AJPH.2014.302130
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AP1XG
UT WOS:000341865000021
PM 25122010
ER
PT J
AU Beaulieu, JJ
Mayer, PM
Kaushal, SS
Pennino, MJ
Arango, CP
Balz, DA
Canfield, TJ
Elonen, CM
Fritz, KM
Hill, BH
Ryu, H
Domingo, JWS
AF Beaulieu, Jake J.
Mayer, Paul M.
Kaushal, Sujay S.
Pennino, Michael J.
Arango, Clay P.
Balz, David A.
Canfield, Timothy J.
Elonen, Colleen M.
Fritz, Ken M.
Hill, Brian H.
Ryu, Hodon
Domingo, Jorge W. Santo
TI Effects of urban stream burial on organic matter dynamics and reach
scale nitrate retention
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Extracellular enzyme activity; Stable isotope; Bacteria; Uptake length;
Uptake velocity; N-15
ID OXYGEN CHANGE TECHNIQUE; NUTRIENT-UPTAKE; ADDITION EXPERIMENTS;
HEADWATER STREAMS; TEMPORAL VARIATION; FRESH-WATER; METABOLISM;
RESTORATION; NITROGEN; DENITRIFICATION
AB Nitrogen (N) retention in streams is an important ecosystem service that may be affected by the widespread burial of streams in stormwater pipes in urban watersheds. We predicted that stream burial suppresses the capacity of streams to retain nitrate (NO3 (-)) by eliminating primary production, reducing respiration rates and organic matter availability, and increasing specific discharge. We tested these predictions by measuring whole-stream NO3 (-) removal rates using (NO3)-N-15 (-) isotope tracer releases in paired buried and open reaches in three streams in Cincinnati, Ohio (USA) during four seasons. Nitrate uptake lengths were 29 times greater in buried than open reaches, indicating that buried reaches were less effective at retaining NO3 (-) than open reaches. Burial suppressed NO3 (-) retention through a combination of hydrological and biological processes. The channel shape of two of the buried reaches increased specific discharge which enhanced NO3 (-) transport from the channel, highlighting the relationship between urban infrastructure and ecosystem function. Uptake lengths in the buried reaches were further lengthened by low stream biological NO3 (-) demand, as indicated by NO3 (-) uptake velocities 17-fold lower than that of the open reaches. We also observed differences in the periphyton enzyme activity between reaches, indicating that the effects of burial cascade from the microbial to the ecosystem scale. Our results suggest that stream restoration practices involving "daylighting" buried streams have the potential to increase N retention. Further work is needed to elucidate the impacts of stream burial on ecosystem functions at the larger stream network scale.
C1 [Beaulieu, Jake J.; Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Mayer, Paul M.; Canfield, Timothy J.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74821 USA.
[Kaushal, Sujay S.; Pennino, Michael J.] Univ Maryland, Dept Geol, College Pk, MD 20742 USA.
[Kaushal, Sujay S.; Pennino, Michael J.] Univ Maryland, Earth Syst Interdisciplinary Ctr, College Pk, MD 20742 USA.
[Arango, Clay P.] Cent Washington Univ, Dept Biol Sci, Ellensburg, WA 98926 USA.
[Balz, David A.] Pegasus Tech Serv, Cincinnati, OH 45268 USA.
[Elonen, Colleen M.; Hill, Brian H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
[Fritz, Ken M.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Beaulieu, JJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM beaulieu.jake@epa.gov
RI Kaushal, Sujay/G-1062-2013;
OI Kaushal, Sujay/0000-0003-0834-9189; Mayer, Paul/0000-0002-8550-1386
FU Pegasus Technical Services [EP-C-11-006]
FX We thank numerous private land owners for site access and the Cincinnati
Metropolitan Sewer District for assistance with site selection. Field
and laboratory support was provided by Pegasus Technical Services under
contract #EP-C-11-006.
NR 73
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U1 3
U2 51
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
EI 1573-515X
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD OCT
PY 2014
VL 121
IS 1
BP 107
EP 126
DI 10.1007/s10533-014-9971-4
PG 20
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA AP2NG
UT WOS:000341908600006
ER
PT J
AU Cooper, CA
Mayer, PM
Faulkner, BR
AF Cooper, Curtis A.
Mayer, Paul M.
Faulkner, Barton R.
TI Effects of road salts on groundwater and surface water dynamics of
sodium and chloride in an urban restored stream
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Road salt; Chloride; Sodium; Chesapeake Bay; Water quality; Groundwater;
Urban stream; Restoration
ID DEICING SALT; NITROGEN DYNAMICS; DISSOLVED SOLIDS; DEGRADED URBAN;
DENITRIFICATION; SOILS; ACCUMULATION; RESTORATION; STORMWATER; RUNOFF
AB Road salts are a growing environmental concern in urban watersheds. We examined groundwater (GW) and surface water (SW) dynamics of Na+ and Cl- in Minebank Run (MBR), an urban stream in Maryland, USA. We observed an increasing salinity trend in this restored stream. Current baseflow salinity does not exceed water quality recommendations, but rapid "first flush" storm flow was approximately one-third that of seawater. Comparisons between the upstream and downstream study reaches suggest that a major interstate highway is the primary road salt source. A heavily used road parallels most of MBR and was an additional source to GW concentrations, especially the downstream right bank. A baseflow synoptic survey identified zones of increased salinity. Downstream piezometer wells exhibited increases in salt concentrations and there was evidence that Na+ is exchanging Ca2+ and Mg2+ on soils. SW salt concentrations were generally elevated above GW concentrations. Salinity levels persisted at MBR throughout the year and were above background levels at Bynum Run, a nearby reference stream not bisected by a major highway, suggesting that GW is a long-term reservoir for accumulating road salts. Chronic salinity levels may be high enough to damage vegetation and salinity peaks could impact other biota. Beneficial uses and green infrastructure investments may be at risk from salinity driven degradation. Therefore, road salt may represent an environmental risk that could affect aquatic biota and limit the effectiveness of costly resource management and restoration efforts.
C1 [Cooper, Curtis A.; Mayer, Paul M.; Faulkner, Barton R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
RP Cooper, CA (reprint author), Idaho Dept Environm Qual, 900 North Skyline Dr,Suite B, Idaho Falls, ID 83402 USA.
EM curtis.cooper@deq.idaho.gov
OI Mayer, Paul/0000-0002-8550-1386
NR 88
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U2 129
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
EI 1573-515X
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD OCT
PY 2014
VL 121
IS 1
BP 149
EP 166
DI 10.1007/s10533-014-9968-z
PG 18
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA AP2NG
UT WOS:000341908600008
ER
PT J
AU Pennino, MJ
Kaushal, SS
Beaulieu, JJ
Mayer, PM
Arango, CP
AF Pennino, Michael J.
Kaushal, Sujay S.
Beaulieu, Jake J.
Mayer, Paul M.
Arango, Clay P.
TI Effects of urban stream burial on nitrogen uptake and ecosystem
metabolism: implications for watershed nitrogen and carbon fluxes
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Carbon quality; Fluorescence excitation-emission matrices; Stream
channelization; Stream daylighting; Transient storage; Tracer injection
ID DISSOLVED ORGANIC-MATTER; OXYGEN CHANGE TECHNIQUE; HYPORHEIC ZONE;
HEADWATER STREAMS; TRANSIENT STORAGE; NUTRIENT-UPTAKE; CURRENT
KNOWLEDGE; FLUORESCENCE SPECTROSCOPY; GROUNDWATER EXCHANGE; CHANNEL
RESTORATION
AB Urbanization has resulted in the extensive burial and channelization of headwater streams, yet little is known about the impacts of stream burial on ecosystem functions critical for reducing downstream nitrogen (N) and carbon (C) exports. In order to characterize the biogeochemical effects of stream burial on N and C, we measured NO3 (-) uptake (using N-15-NO3 (-) isotope tracer releases) and gross primary productivity (GPP) and ecosystem respiration (ER) (using whole stream metabolism measurements). Experiments were carried out during four seasons, in three paired buried and open stream reaches, within the Baltimore Ecosystem Study Long-term Ecological Research site. Stream burial increased NO3 (-) uptake lengths by a factor of 7.5 (p < 0.01) and decreased NO3 (-) uptake velocity and areal NO3 (-) uptake rate by factors of 8.2 (p < 0.05) and 9.6 (p < 0.001), respectively. Stream burial decreased GPP by a factor of 11.0 (p < 0.01) and decreased ER by a factor of 5.0 (p < 0.05). From fluorescence Excitation Emissions Matrices analysis, buried streams were found to have significantly altered C quality, showing less labile dissolved organic matter. Furthermore, buried streams had significantly lower transient storage (TS) and water temperatures. Differences in NO3 (-) uptake, GPP, and ER in buried streams, were primarily explained by decreased TS, light availability, and C quality, respectively. At the watershed scale, we estimate that stream burial decreases NO3 (-) uptake by 39 % and C production by 194 %. Overall, our results suggest that stream burial significantly impacts NO3 (-) uptake, stream metabolism, and the quality of organic C exported from watersheds. Given the large impacts of stream burial on stream ecosystem processes, daylighting or de-channelization of streams, through hydrologic floodplain reconnection, may have the potential to alter ecosystem functions in urban watersheds, when used appropriately.
C1 [Pennino, Michael J.] Univ Maryland Baltimore Cty, Marine Estuarine Environm Studies Dept, Baltimore, MD 21250 USA.
[Kaushal, Sujay S.] Univ Maryland, Dept Geol, College Pk, MD 20740 USA.
[Kaushal, Sujay S.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
[Beaulieu, Jake J.] US EPA, Natl Risk Management Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Mayer, Paul M.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Arango, Clay P.] Cent Washington Univ, Dept Biol Sci, Ellensburg, WA 98926 USA.
RP Pennino, MJ (reprint author), Univ Maryland Baltimore Cty, Marine Estuarine Environm Studies Dept, Baltimore, MD 21250 USA.
EM michael.pennino@gmail.com
RI Kaushal, Sujay/G-1062-2013;
OI Kaushal, Sujay/0000-0003-0834-9189; Mayer, Paul/0000-0002-8550-1386
FU EPA NNEMS [2010-309]; NSF [DBI 0640300, CBET 1058502, DGE-1144243]; NASA
[NASA NNX11AM28G]; Maryland Sea Grant Awards [SA7528085-U, R/WS-2,
NA05OAR4171042]; Baltimore Ecosystem Study LTER project [NSF
DEB-0423476]; U.S. Environmental Protection Agency through its Office of
Research and Development
FX This research was supported by EPA NNEMS Award 2010-309, the NSF
Graduate Research Fellowship Program under Grant No. DGE-1144243, NSF
Awards DBI 0640300 and CBET 1058502, NASA grant NASA NNX11AM28G,
Maryland Sea Grant Awards SA7528085-U, R/WS-2 and NA05OAR4171042, and
Baltimore Ecosystem Study LTER project (NSF DEB-0423476). We thank Kevin
Danaher, Kevin Magerr, Evan Smith and Benjamin Wu for field assistance.
Tammy Newcomer and Rose Smith provided help in the field and helpful
comments on a previous version of the manuscript. The U.S. Environmental
Protection Agency, through its Office of Research and Development,
funded and managed, or partially funded and collaborated in, the
research described herein. It has been subjected to the Agency's
administrative review and has been approved for external publication.
Any opinions expressed in this paper are those of the author (s) and do
not necessarily reflect the views of the Agency, therefore, no official
endorsement should be inferred. Any mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
NR 126
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U1 2
U2 56
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
EI 1573-515X
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD OCT
PY 2014
VL 121
IS 1
BP 247
EP 269
DI 10.1007/s10533-014-9958-1
PG 23
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA AP2NG
UT WOS:000341908600013
ER
PT J
AU Dias, E
Morais, P
Antunes, C
Hoffman, JC
AF Dias, Ester
Morais, Pedro
Antunes, Carlos
Hoffman, Joel C.
TI Linking terrestrial and benthic estuarine ecosystems: organic matter
sources supporting the high secondary production of a non-indigenous
bivalve
SO BIOLOGICAL INVASIONS
LA English
DT Article
DE Corbicula fluminea; Stable isotopes; Benthic food web; Minho estuary
ID CLAM CORBICULA-FLUMINEA; STABLE-ISOTOPE ANALYSIS; FRESH-WATER
ECOSYSTEMS; SAN-FRANCISCO BAY; ASIATIC CLAM; FOOD WEBS; PHYTOPLANKTON
BIOMASS; LIPID CORRECTION; FUNCTIONAL-ROLE; ZEBRA MUSSELS
AB The Asian clam, Corbicula fluminea, is among the most pervasive invasive species in freshwater ecosystems worldwide. Our objective was to study C. fluminea's functional response in terms of feeding behavior and food selectivity, using the natural variation in organic matter (OM) sources that occur in estuarine environments. Using C and N stable isotopes, we identified and quantified the contribution of different OM sources supporting the production of C. fluminea along the salinity gradient occupied in the Minho River estuary (NW-Iberian Peninsula, Europe), where this species presently dominates the benthic macrofauna biomass. We observed a pronounced shift in the quality of OM available for C. fluminea along the estuarine mixing zone. Stable isotope analysis, POM C/N, and phytoplankton contribution estimates based on C:Chl a revealed that POM was largely comprised of terrestrial-derived OM in tidal freshwater stations (TFW) and was increasingly comprised of phytoplankton, a more palatable food source, towards the polyhaline estuary. A similar shift in the isotopic composition along the estuarine mixing zone was observed in C. fluminea, suggesting a shift in food resources. Accordingly, based on a Bayesian stable isotope mixing model, there was an upstream-downstream counter gradient in the contribution to C. fluminea biomass from terrestrial-derived OM (41-64 % in TFW) and phytoplankton (29-55 % in the brackish estuary). Although the majority of the food sources identified were filtered from the water column (70-80 %), reliance on sediment OM and microphytobenthos provided evidence for deposit feeding by C. fluminea. We conclude that C. fluminea has the ability to adapt to environments with low food quality because it can consume terrestrial-derived OM. This can be a competitive adaptation in systems with perennial low food quality such as the Minho River estuary. Moreover, its ability to couple benthic and pelagic environments and terrestrial ecosystems demonstrates a strong potential to alter food web flows in aquatic ecosystems.
C1 [Dias, Ester] Univ Porto, ICBAS, P-4050313 Oporto, Portugal.
[Dias, Ester; Morais, Pedro; Antunes, Carlos] Univ Porto, CIIMAR CIMAR, Ctr Interdisciplinar Invest Marinha & Ambiental, P-4050123 Oporto, Portugal.
[Morais, Pedro] Univ Algarve, CIMA, P-8005139 Faro, Portugal.
[Antunes, Carlos] Aquamuseu Rio Minho, P-4920290 Vila Nova De Cerveira, Portugal.
[Antunes, Carlos] ESG, P-4920 Vila Nova De Cerveira, Portugal.
[Hoffman, Joel C.] US EPA, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA.
RP Dias, E (reprint author), Univ Porto, CIIMAR CIMAR, Ctr Interdisciplinar Invest Marinha & Ambiental, Rua Bragas 289, P-4050123 Oporto, Portugal.
EM esterdias@ciimar.up.pt
RI Morais, Pedro/F-2815-2011;
OI Morais, Pedro/0000-0002-0861-5566; Dias, Ester/0000-0003-0526-4462;
Antunes, Carlos/0000-0003-3736-5743
FU Iceland, Liechtenstein and Norway through the EEA Financial Mechanism;
Norwegian Financial Mechanism; Fundacao para a Ciencia e Tecnologia,
Portugal [SFRH/BPD/40832/2007]; Project MIGRANET SOE [2/P2E288]
FX We thank Eduardo Martins, Joana Campos and the staff at Aquamuseu do Rio
Minho for their help while conducting the field work; Anne M. Cotter for
preparing POM samples for stable isotope analysis, for running the
samples and for all the technical support with the IRMS; Rute Pinto for
providing the map of the study area; and three anonymous reviewers for
their helpful comments. E. Dias was supported by a Ph.D. Grant from
Iceland, Liechtenstein and Norway through the EEA Financial Mechanism
and the Norwegian Financial Mechanism. P. Morais was supported by a
post-doc scholarship financed by Fundacao para a Ciencia e Tecnologia,
Portugal (SFRH/BPD/40832/2007). This work was partially supported by the
Project MIGRANET SOE 2/P2E288. The views expressed in this paper are
those of the authors and do not necessarily reflect the views or
policies of the U.S. EPA.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1387-3547
EI 1573-1464
J9 BIOL INVASIONS
JI Biol. Invasions
PD OCT
PY 2014
VL 16
IS 10
BP 2163
EP 2179
DI 10.1007/s10530-014-0655-8
PG 17
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AP0VC
UT WOS:000341782600012
ER
PT J
AU Ryan, SP
Lee, SD
Calfee, MW
Wood, JP
McDonald, S
Clayton, M
Griffin-Gatchalian, N
Touati, A
Smith, L
Nysewander, M
AF Ryan, Shawn P.
Lee, Sang Don
Calfee, M. Worth
Wood, Joseph P.
McDonald, Stella
Clayton, Matt
Griffin-Gatchalian, Nicole
Touati, Abderrahmane
Smith, Luther
Nysewander, Melissa
TI Effect of inoculation method on the determination of decontamination
efficacy against Bacillus spores
SO WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
LA English
DT Article
DE Decontamination; Sporicide; Anthrax; Bacillus anthracis
ID GEOBACILLUS-STEAROTHERMOPHILUS SPORES; ANTHRACIS SPORES; INACTIVATION;
SUBTILIS; SURFACES; GAS; SCALE
AB Decontamination studies investigating the effectiveness of products and processes for the inactivation of Bacillus species spores have traditionally utilized metering viable spores in a liquid suspension onto test materials (coupons). The current study addresses the representativeness of studies using this type of inoculation method compared to when coupons are dosed with a metered amount of aerosolized spores. The understanding of this comparability is important in order to assess the representativeness of such laboratory-based testing when deciding upon decontamination options for use against Bacillus anthracis spores. Temporal inactivation of B. anthracis surrogate (B. subtilis) spores on representative materials using fumigation with chlorine dioxide, spraying of a pH-adjusted bleach solution, or immersion in the solution was investigated as a function of inoculation method (liquid suspension or aerosol dosing). Results indicated that effectiveness, measured as log reduction, was statistically significantly lower when liquid inoculation was used for some material and decontaminant combinations. Differences were mostly noted for the materials observed to be more difficult to decontaminate (i.e., wood and carpet). Significant differences in measured effectiveness were also noted to be a function of the pH-adjusted bleach application method used in the testing (spray or immersion). Based upon this work and the cited literature, it is clear that inoculation method, decontaminant application method, and handling of non-detects (i.e., or detection limits) can have an impact on the sporicidal efficacy measurements.
C1 [Ryan, Shawn P.; Lee, Sang Don; Calfee, M. Worth; Wood, Joseph P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
[McDonald, Stella; Clayton, Matt; Griffin-Gatchalian, Nicole; Touati, Abderrahmane] Arcadis Geraghty & Miller Inc, Durham, NC USA.
[Smith, Luther; Nysewander, Melissa] Alion Sci & Technol Inc, Durham, NC USA.
RP Ryan, SP (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM ryan.shawn@epa.gov
OI Wood, Joseph/0000-0001-6316-9418
FU Alion Science and Technology, Inc. [EP-D-10-070]
FX The authors acknowledge the expert contributions of Dr. Vipin Rastogi
and his colleagues at the Edgewood Chemical and Biological Center for
their helpful advice and for providing access to the MDIs used in this
work. The U.S. Environmental Protection Agency through its Office of
Research and Development directed the research described herein under
EP-C-04-023 with ARCADIS Inc. The statistical analysis was funded under
EP-D-10-070 with Alion Science and Technology, Inc. This manuscript has
been subject to an administrative review but does not necessarily
reflect the views of the Agency. No official endorsement should be
inferred. EPA does not endorse the purchase or sale of any commercial
products or services.
NR 38
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U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0959-3993
EI 1573-0972
J9 WORLD J MICROB BIOT
JI World J. Microbiol. Biotechnol.
PD OCT
PY 2014
VL 30
IS 10
BP 2609
EP 2623
DI 10.1007/s11274-014-1684-2
PG 15
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA AO8WD
UT WOS:000341635000007
PM 24928258
ER
PT J
AU Ju, YS
Futreal, CA
Gerstung, M
Martincorena, I
Nik-Zainal, S
Ramakrishna, M
Davies, HR
Papaemmanuil, E
Gundem, G
Shlien, A
Bolli, N
Behjati, S
Tarpey, PS
Nangalia, J
Massie, CE
Butler, AP
Teague, JW
Vassiliou, GS
Green, AR
Du, MQ
Unnikrishnan, A
Pimanda, JE
Teh, BT
Munshi, N
Greaves, M
Vyas, P
El-Naggar, AK
Santarius, T
Collins, VP
Grundy, R
Taylor, JA
Hayes, DN
Malkin, D
Foster, CS
Warren, AY
Whitaker, HC
Brewer, D
Eeles, R
Cooper, C
Neal, D
Visakorpi, T
Isaacs, WB
Bova, GS
Flanagan, AM
Futreal, PA
Lynch, AG
Chinnery, PF
McDermott, U
Stratton, MR
Campbell, PJ
AF Ju, Young Seok
Alexandrov, Ludmil B.
Gerstung, Moritz
Martincorena, Inigo
Nik-Zainal, Serena
Ramakrishna, Manasa
Davies, Helen R.
Papaemmanuil, Elli
Gundem, Gunes
Shlien, Adam
Bolli, Niccolo
Behjati, Sam
Tarpey, Patrick S.
Nangalia, Jyoti
Massie, Charles E.
Butler, Adam P.
Teague, Jon W.
Vassiliou, George S.
Green, Anthony R.
Du, Ming-Qing
Unnikrishnan, Ashwin
Pimanda, John E.
Teh, Bin Tean
Munshi, Nikhil
Greaves, Mel
Vyas, Paresh
El-Naggar, Adel K.
Santarius, Tom
Collins, V. Peter
Grundy, Richard
Taylor, Jack A.
Hayes, D. Neil
Malkin, David
Foster, Christopher S.
Warren, Anne Y.
Whitaker, Hayley C.
Brewer, Daniel
Eeles, Rosalind
Cooper, Colin
Neal, David
Visakorpi, Tapio
Isaacs, William B.
Bova, G. Steven
Flanagan, Adrienne M.
Futreal, P. Andrew
Lynch, Andy G.
Chinnery, Patrick F.
McDermott, Ultan
Stratton, Michael R.
Campbell, Peter J.
CA ICGC Breast Canc Grp
ICGC Chronic Myeloid Disorders Grp
ICGC Prostate Canc Grp
TI Origins and functional consequences of somatic mitochondrial DNA
mutations in human cancer
SO ELIFE
LA English
DT Article
ID 21 BREAST CANCERS; POPULATION-GENETICS; POLYMERASE-GAMMA;
LAGGING-STRAND; HUMAN-DISEASE; STEM-CELLS; GENOME; HETEROPLASMY;
REPLICATION; EVOLUTION
AB Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed somatic alterations in mtDNA from 1,675 tumors across 31 histologies. We identified 1,907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C>T and A>G on the mitochondrial heavy strand. This strand-asymmetric signature differs from those found in nuclear cancer genomes but matches the inferred germline process shaping primate mtDNA sequence content. Numbers of mtDNA mutations showed considerable heterogeneity across tumor types. Missense mutations were selectively neutral and often gradually drifted towards homoplasmy over time. In contrast, mutations resulting in protein truncation undergo negative selection and were almost exclusively heteroplasmic. Our findings indicate that the endogenous mutational mechanism has far greater impact than any other external mutagens in mitochondria, and is fundamentally linked to mtDNA replication.
C1 [Ju, Young Seok; Alexandrov, Ludmil B.; Gerstung, Moritz; Martincorena, Inigo; Nik-Zainal, Serena; Ramakrishna, Manasa; Davies, Helen R.; Papaemmanuil, Elli; Gundem, Gunes; Shlien, Adam; Bolli, Niccolo; Behjati, Sam; Tarpey, Patrick S.; Nangalia, Jyoti; Massie, Charles E.; Butler, Adam P.; Teague, Jon W.; Vassiliou, George S.; Futreal, P. Andrew; Stratton, Michael R.; ICGC Breast Canc Grp; ICGC Chronic Myeloid Disorders Grp] Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England.
[Nangalia, Jyoti; Massie, Charles E.; Vassiliou, George S.; Green, Anthony R.; Du, Ming-Qing; Santarius, Tom; Collins, V. Peter; Warren, Anne Y.; McDermott, Ultan; Campbell, Peter J.] Cambridge Univ Hosp NHS Trust, Cambridge, England.
[Nangalia, Jyoti; Massie, Charles E.; Vassiliou, George S.; Green, Anthony R.; Campbell, Peter J.] Univ Cambridge, Dept Hematol, Cambridge, England.
[Unnikrishnan, Ashwin; Pimanda, John E.] Univ New S Wales, Lowy Canc Res Ctr, Sydney, NSW, Australia.
[Teh, Bin Tean] Natl Canc Ctr, Lab Canc Epigenome, Singapore, Singapore.
[Teh, Bin Tean] Duke Nus Grad Med Sch, Singapore, Singapore.
[Munshi, Nikhil] Dana Farber Canc Inst, Boston, MA 02115 USA.
[Greaves, Mel; Brewer, Daniel; Eeles, Rosalind; Cooper, Colin] Inst Canc Res, Sutton, Surrey, England.
[Vyas, Paresh] Univ Oxford, Weatherall Inst Mol Med, Oxford, England.
[El-Naggar, Adel K.; Futreal, P. Andrew] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Grundy, Richard] Univ Nottingham, Childrens Brain Tumor Res Ctr, Nottingham NG7 2RD, England.
[Taylor, Jack A.] NIH, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Hayes, D. Neil] Univ N Carolina, Chapel Hill, NC 27515 USA.
[Malkin, David] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Whitaker, Hayley C.; Neal, David; ICGC Prostate Canc Grp] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.
[Foster, Christopher S.] Univ Liverpool, London, England.
[Foster, Christopher S.] HCA Pathol Labs, London, England.
[Brewer, Daniel; Cooper, Colin] Univ E Anglia, Norwich NR4 7TJ, Norfolk, England.
[Visakorpi, Tapio; Bova, G. Steven] Univ Tampere, Inst Biomed Technol, FIN-33101 Tampere, Finland.
[Visakorpi, Tapio; Bova, G. Steven] Univ Tampere, BioMediTech, FIN-33101 Tampere, Finland.
[Isaacs, William B.] Johns Hopkins Univ, Baltimore, MD USA.
[Flanagan, Adrienne M.] Royal Natl Orthopaed Hosp, Stanmore, Middx, England.
[Flanagan, Adrienne M.] UCL, UCL Canc Inst, London, England.
[Chinnery, Patrick F.] Univ Newcastle, Inst Med Genet, Wellcome Ctr Mitochondrial Res, Newcastle Upon Tyne, Tyne & Wear, England.
RP Campbell, PJ (reprint author), Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England.
EM pc8@sanger.ac.uk
RI Ju, Young Seok/E-1324-2012; Bolli, Niccolo/D-4057-2011;
OI taylor, jack/0000-0001-5303-6398; Massie, Charlie/0000-0003-2314-4843;
Ju, Young Seok/0000-0002-5514-4189; Bolli, Niccolo/0000-0002-1018-5139;
Ehinger, Anna/0000-0001-9225-7396; Gerstung, Moritz/0000-0001-6709-963X;
Eeles, Rosalind/0000-0002-3698-6241; Vassiliou,
George/0000-0003-4337-8022; Vyas, Paresh/0000-0003-3931-0914; McDermott,
Ultan/0000-0001-9032-4700; Martin, Sancha/0000-0001-6213-5259;
Unnikrishnan, Ashwin/0000-0001-5168-8755
FU Wellcome Trust; British Lung Foundation; Health Innovation Challenge
Fund; Kay Kendall Leukaemia Fund; Chordoma Foundation; Adenoid Cystic
Carcinoma Research Foundation; EMBO long-term fellowship [ALTF
1203-2012, ALTF 1287-2012]; National Institute for Health Research
(NIHR) UCLH Biomedical Research Centre; Leukaemia Lymphoma Research;
Cancer Research UK; Leukemia Lymphoma Society; European Union (BASIS);
National Cancer Research Prostate Cancer: Mechanisms of Progression and
Treatment (PROMPT) collaborative [G0500966/75466]; Intramural Research
Program of the NIH, National Institute of Environmental Health Sciences
FX Data used in this manuscript are described in the supplementary
materials (Supplementary file 1). We thank Thomas Bleazard at Faculty of
Medical and Human Sciences, University of Manchester for discussion and
assistance with manuscript preparation. We would like to thank The
Cancer Genome Atlas (TCGA) Project Team and their specimen donors for
providing sequencing data. This work was supported by the Wellcome
Trust, the British Lung Foundation, the Health Innovation Challenge
Fund, the Kay Kendall Leukaemia Fund, the Chordoma Foundation and the
Adenoid Cystic Carcinoma Research Foundation. Y.S.J and I.M. are
supported by EMBO long-term fellowship (ALTF 1203-2012 and ALTF
1287-2012, respectively). P.J.C. is a Wellcome Trust Senior Clinical
Fellow. Support was provided to A.M.F. by the National Institute for
Health Research (NIHR) UCLH Biomedical Research Centre. A.R.G. receives
support from Leukaemia Lymphoma Research, Cancer Research UK and the
Leukemia Lymphoma Society. Samples from Addenbrooke's Hospital were
collected with support from the NIHR Cambridge Biomedical Resource
Centre. The ICGC Breast Cancer Consortium was supported by a grant from
the European Union (BASIS) and the Wellcome Trust. The ICGC Prostate
Cancer Consortium was funded by Cancer Research UK. We would also like
to acknowledge the support of the National Cancer Research Prostate
Cancer: Mechanisms of Progression and Treatment (PROMPT) collaborative
(grant code G0500966/75466) which has funded tissue and urine
collections in Cambridge. This research was supported in part by the
Intramural Research Program of the NIH, National Institute of
Environmental Health Sciences (J.A.T.). We obtained informed consent and
consent to publish from participants enrolled.
NR 59
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PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD OCT 1
PY 2014
VL 3
AR e02935
DI 10.7554/eLife.02935
PG 53
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AR2JI
UT WOS:000343409900003
ER
PT J
AU Jaglom, WS
McFarland, JR
Colley, MF
Mack, CB
Venkatesh, B
Miller, RL
Haydel, J
Schultz, PA
Perkins, B
Casola, JH
Martinich, JA
Cross, P
Kolian, MJ
Kayin, S
AF Jaglom, Wendy S.
McFarland, James R.
Colley, Michelle F.
Mack, Charlotte B.
Venkatesh, Boddu
Miller, Rawlings L.
Haydel, Juanita
Schultz, Peter A.
Perkins, Bill
Casola, Joseph H.
Martinich, Jeremy A.
Cross, Paul
Kolian, Michael J.
Kayin, Serpil
TI Assessment of projected temperature impacts from climate change on the
U.S. electric power sector using the Integrated Planning Model (R)
SO ENERGY POLICY
LA English
DT Article
DE Climate change; Electricity demand; Electric power sector
ID ENERGY DEMAND; FRAMEWORK; US
AB This study analyzes the potential impacts of changes in temperature due to climate change on the U.S. power sector, measuring the energy, environmental, and economic impacts of power system changes due to temperature changes under two emissions trajectories with and without emissions mitigation. It estimates the impact of temperature change on heating and cooling degree days, electricity demand, and generating unit output and efficiency. These effects are then integrated into a dispatch and capacity planning model to estimate impacts on investment decisions, emissions, system costs, and power prices for 32 U.S. regions. Without mitigation actions, total annual electricity production costs in 2050 are projected to increase 14% ($51 billion) because of greater cooling demand as compared to a control scenario without future temperature changes. For a scenario with global emissions mitigation, including a reduction in U.S. power sector emissions of 36% below 2005 levels in 2050, the increase in total annual electricity production costs is approximately the same as the increase in system costs to satisfy the increased demand associated with unmitigated rising temperatures. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
C1 [Jaglom, Wendy S.; Colley, Michelle F.; Mack, Charlotte B.; Venkatesh, Boddu; Miller, Rawlings L.; Haydel, Juanita; Schultz, Peter A.; Cross, Paul] ICF Int, Fairfax, VA 22031 USA.
[McFarland, James R.; Perkins, Bill; Casola, Joseph H.; Martinich, Jeremy A.; Kolian, Michael J.; Kayin, Serpil] US EPA, Washington, DC 20460 USA.
RP Colley, MF (reprint author), Suite 300 222 Somerset St West, Ottawa, ON K2P 2G3, Canada.
EM michelle.colley@icfi.com
FU U.S. Environmental Protection Agency's Climate Change Division
FX The authors wish to acknowledge the financial support of the U.S.
Environmental Protection Agency's Climate Change Division and the
valuable input of two anonymous reviewers. The views expressed in this
document are solely those of the authors and do not necessarily reflect
those of EPA.
NR 39
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0301-4215
EI 1873-6777
J9 ENERG POLICY
JI Energy Policy
PD OCT
PY 2014
VL 73
BP 524
EP 539
DI 10.1016/j.enpol.2014.04.032
PG 16
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA AO6PN
UT WOS:000341474100049
ER
PT J
AU Ma, HB
Wallis, LK
Diamond, S
Li, SB
Canas-Carrell, J
Parra, A
AF Ma, Hongbo
Wallis, Lindsay K.
Diamond, Steve
Li, Shibin
Canas-Carrell, Jaclyn
Parra, Amanda
TI Impact of solar UV radiation on toxicity of ZnO nanoparticles through
photocatalytic reactive oxygen species (ROS) generation and
photo-induced dissolution
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE ZnO nanoparticles; UV radiation; Reactive oxygen species (ROS);
Photo-induced dissolution; Toxicity
ID NEMATODE CAENORHABDITIS-ELEGANS; BIOTIC LIGAND MODEL; DAPHNIA-MAGNA;
BULK ZNO; PSEUDOKIRCHNERIELLA-SUBCAPITATA; ULTRAVIOLET-RADIATION;
MARINE-PHYTOPLANKTON; OXIDE NANOPARTICLES; TIO2 NANOPARTICLES; ZINC
TOXICITY
AB The present study investigated the impact of solar UV radiation on ZnO nanoparticle toxicity through photocatalytic ROS generation and photo-induced dissolution. Toxicity of ZnO nanoparticles to Daphnia magna was examined under laboratory light versus simulated solar UV radiation (SSR). Photocatalytic ROS generation and particle dissolution were measured on a time-course basis. Two toxicity mitigation assays using CaCl2 and N-acetylcysteine were performed to differentiate the relative importance of these two modes of action. Enhanced ZnO nanoparticle toxicity under SSR was in parallel with photocatalytic ROS generation and enhanced particle dissolution. Toxicity mitigation by CaCl2 to a less extent under SSR than under lab light demonstrates the role of ROS generation in ZnO toxicity. Toxicity mitigation by N-acetylcysteine under both irradiation conditions confirms the role of particle dissolution and ROS generation. These findings demonstrate the importance of considering environmental solar UV radiation when assessing ZnO nanopartide toxicity and risk in aquatic systems. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ma, Hongbo; Wallis, Lindsay K.; Li, Shibin] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA.
[Diamond, Steve] Nanosafe Inc, Blacksburg, VA USA.
[Canas-Carrell, Jaclyn; Parra, Amanda] Texas Tech Univ, Dept Environm Toxicol, Lubbock, TX 79409 USA.
RP Ma, HB (reprint author), Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.
EM hongboma@uwm.edu
FU National Research Council Research Associateship Award at the U.S.
Environmental Protection Agency, Mid-Continent Ecology Division
Laboratory
FX The present study was performed while one of the authors, H. Ma, held a
National Research Council Research Associateship Award at the U.S.
Environmental Protection Agency, Mid-Continent Ecology Division
Laboratory.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD OCT
PY 2014
VL 193
BP 165
EP 172
DI 10.1016/j.envpol.2014.06.027
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OL
UT WOS:000341471300021
PM 25033018
ER
PT J
AU Van Meter, RJ
Glinski, DA
Hong, T
Cyterski, M
Henderson, WM
Purucker, ST
AF Van Meter, Robin J.
Glinski, Donna A.
Hong, Tao
Cyterski, Mike
Henderson, W. Matthew
Purucker, S. Thomas
TI Estimating terrestrial amphibian pesticide body burden through dermal
exposure
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE K-ow; K-oc; Bioaccumulation; Skin permeability; Frog
ID ACUTE TOXICITY; WATER-LOSS; FROGS; ADAPTATIONS; MALATHION; DECLINE;
DISEASE; MODEL; SKIN
AB Dermal exposure presents a potentially significant but understudied route for pesticide uptake in terrestrial amphibians. Our study measured dermal uptake of pesticides of varying hydrophobicity (logK(ow)) in frogs. Amphibians were indirectly exposed to one of five pesticide active ingredients through contact with contaminated soil: imidacloprid (logK(ow) = 0.57), atrazine (logK(ow) = 2.5), triadimefon (logK(ow) = 3.0), fipronil (logK(ow) = 4.11) or pendimethalin (logK(ow) = 5.18). All amphibians had measurable body burdens at the end of the exposure in concentrations ranging from 0.019 to 14.562 mu g/g across the pesticides tested. Atrazine produced the greatest body burdens and bioconcentration factors, but fipronil was more permeable to amphibian skin when application rate was considered. Soil partition coefficient and water solubility were much better predictors of pesticide body burden, bioconcentration factor, and skin permeability than logK(ow). Dermal uptake data can be used to improve risk estimates of pesticide exposure among amphibians as non-target organisms. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Van Meter, Robin J.; Glinski, Donna A.; Hong, Tao] Oak Ridge Inst Sci & Educ, Ecosyst Res Div, Athens, GA 30605 USA.
[Cyterski, Mike; Henderson, W. Matthew; Purucker, S. Thomas] US EPA, Ecosyst Res Div, Athens, GA USA.
RP Van Meter, RJ (reprint author), Oak Ridge Inst Sci & Educ, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM rvanmeter2@washcoll.edu
FU USEPA Ecosystems Research Division, Athens, GA [DW8992298301]
FX We gratefully acknowledge the efforts of Wayne Garrison and Jimmy Avants
for assistance in developing our amphibian tissue extraction protocol.
The EPA Office of Pesticide Programs provided valuable feedback on study
design. Thanks to Caroline Stevens for peer review and Fran Rauschenberg
for manuscript review and edits. Many hours of field assistance with
tadpoles and metamorphs was given by Craig Barber, Yin Gu, Katie Price
and Marcia Snyder. This IACUC protocol (A2012 05-018-Y1-A0) received
approval from the University of Georgia Institutional Animal Care and
Use Committee. This research was supported in part by an appointment to
the Postdoctoral Research Program at the USEPA Ecosystems Research
Division, Athens, GA, administered by the Oak Ridge Institute for
Science and Education through Interagency Agreement No. DW8992298301
between the U.S. Department of Energy and the U.S. Environmental
Protection Agency. The views expressed in this article are those of the
authors and do not necessarily represent the views or policies of the
U.S. Environmental Protection Agency.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD OCT
PY 2014
VL 193
BP 262
EP 268
DI 10.1016/j.envpol.2014.07.003
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO6OL
UT WOS:000341471300033
PM 25063914
ER
PT J
AU Darling, JA
Tsai, YHE
Blakeslee, AMH
Roman, J
AF Darling, John A.
Tsai, Yi-Hsin Erica
Blakeslee, April M. H.
Roman, Joe
TI Are genes faster than crabs? Mitochondrial introgression exceeds larval
dispersal during population expansion of the invasive crab Carcinus
maenas
SO ROYAL SOCIETY OPEN SCIENCE
LA English
DT Article
DE introgression; admixture; invasive species; range expansion
AB Biological invasions offer unique opportunities to investigate evolutionary dynamics at the peripheries of expanding populations. Here, we examine genetic patterns associated with admixture between two distinct invasive lineages of the European green crab, Carcinus maenas L., independently introduced to the northwest Atlantic. Previous investigations based on mitochondrial DNA sequences demonstrated that larval dispersal driven by advective currents could explain observed southward displacement of an admixture zone between the two invasions. Comparison of published mitochondrial results with new nuclear data from nine microsatellite loci, however, reveals striking discordance in their introgression patterns. Specifically, introgression of mitochondrial genomes relative to nuclear background suggests that demographic processes such as sex-biased reproductive dynamics and population size imbalancesand not solely larval dispersal- play an important role in driving the evolution of the genetic cline. In particular, the unpredicted introgression of mitochondrial alleles against the direction of mean larval dispersal in the region is consistent with recent models invoking similar demographic processes to explain movements of genes into invading populations. These observations have important implications for understanding historical shifts in C. maenas range limits, and more generally for inferences of larval dispersal based on genetic data.
C1 [Darling, John A.] US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
[Tsai, Yi-Hsin Erica] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA.
[Blakeslee, April M. H.] Long Isl Univ, Dept Biol, Greenvale, NY 11548 USA.
[Roman, Joe] Univ Vermont, Gund Inst Ecol Econ, Burlington, VT 05405 USA.
RP Darling, JA (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM darling.john@epa.gov
FU United States Environmental Protection Agency, through its Office of
Research and Development; National Science Foundation (NSF) [0608310]
FX The United States Environmental Protection Agency, through its Office of
Research and Development, funded and managed the research described
here. Y.E.T. was funded by a National Science Foundation (NSF)
fellowship under grant no. 0608310.
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PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 2054-5703
J9 ROY SOC OPEN SCI
JI R. Soc. Open Sci.
PD OCT
PY 2014
VL 1
IS 2
AR UNSP 140202
DI 10.1098/rsos.140202
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA V44EI
UT WOS:000209731900017
PM 26064543
ER
PT J
AU Crooks, JL
Ozkaynak, H
AF Crooks, James L.
Oezkaynak, Haluk
TI Simultaneous statistical bias correction of multiple PM2.5 species from
a regional photochemical grid model
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air pollution; Bayesian; CMAQ; Multi-pollutant; PM2.5; Splines
ID FINE PARTICULATE MATTER; AIR-POLLUTION EPIDEMIOLOGY; HOSPITAL
ADMISSIONS; NUMERICAL-MODELS; EXPOSURE; CMAQ; DOWNSCALER; SYSTEM; RISK
AB In recent years environmental epidemiologists have begun utilizing regional-scale air quality computer models to predict ambient air pollution concentrations in health studies instead of or in addition to data from fixed-site ambient monitors. The advantages of using such models include better spatio-temporal coverage and the capability to predict concentrations of unmonitored pollutants. However, there are also drawbacks, chief among them being that these models can exhibit systematic spatial and temporal biases. In order to use these models in epidemiological investigations it is very important to bias-correct the model surfaces. We present a novel statistical method of spatio-temporal bias correction for the Community Multi-scale Air Quality (CMAQ) model that allows simultaneous bias adjustment of PM2.5 mass and its major constituent species using publically-available speciated data from ambient monitors. The method uses mass conservation and the more widespread unspeciated PM2.5 mass observations to constrain the sum of the PM2.5 species' concentrations in locations without speciated monitors. We develop the model in the context of an epidemiological study investigating the association between PM2.5 species' ambient concentrations and birth outcomes throughout the state of New Jersey. Since our exposures of interest are multi-month averages we focus specifically on modeling seasonal bias trends rather than daily biases. Using a cross-validation study we find that our bias-corrected CMAQ results are more accurate than either the original CMAQ output or a spline fit without CMAQ More interestingly, we find that our model clearly performs better when mass conservation is enforced, and furthermore that our model is competitive with Kriging in a comparison in which the latter has the advantage. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
C1 [Crooks, James L.; Oezkaynak, Haluk] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
RP Crooks, JL (reprint author), US EPA, Off Res & Dev, 109 TW Alexander Dr,Mail Code 58-C, Res Triangle Pk, NC 27709 USA.
EM crooks.james@epa.gov
FU United States Environmental Protection Agency, through Office of
Research and Development [68-W-01-032 task 61]
FX Disclaimer: The United States Environmental Protection Agency, through
its Office of Research and Development, partially funded and
collaborated in the research described here under contract no.
68-W-01-032 task 61 to Computer Sciences Corporation. It has been
subjected to Agency review and approved for publication. Approval does
not signify that the contents reflect the views of the Agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 36
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U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD OCT
PY 2014
VL 95
BP 126
EP 141
DI 10.1016/j.atmosenv.2014.06.024
PG 16
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AO0CT
UT WOS:000340977400014
ER
PT J
AU Li, SB
Pan, X
Wallis, LK
Fan, ZY
Chen, ZL
Diamond, SA
AF Li, Shibin
Pan, Xuan
Wallis, Lindsay K.
Fan, Zhaoyang
Chen, ZuLiang
Diamond, Stephen A.
TI Comparison of TiO2 nanoparticle and graphene-TiO2 nanoparticle composite
phototoxicity to Daphnia magna and Oryzias latipes
SO CHEMOSPHERE
LA English
DT Article
DE Nano-TiO2; Graphene; Nanocomposite; Phototoxicity; Aquatic organism
ID TITANIUM-DIOXIDE NANOPARTICLES; POLYAROMATIC HYDROCARBONS PAHS; CARBON
NANOTUBES; RADIATION; PHOTOCATALYSIS; AGGREGATION; REACTIVITY; TOXICITY;
SOIL
AB With a dramatic rise in complexity, needs of nanotoxicology research go beyond simple forms of nanomaterials. This study compared the phototoxicity of nano-TiO2 and graphene-TiO2 nanocomposite (GNP). GNP was synthesized based on a hydrothermal method, which simultaneously performed the reduction of graphene oxide and nano-TiO2 loading. A series of acute toxicity tests of nano-TiO2, graphene and GNP was performed on two aquatic organisms, Daphnia magna and Oryzias latipes. Fast and substantial agglomeration and sedimentation of nanoparticles in test media and surface attachment of nano-TiO2 and GNP on D. magna surface was observed. Similar phototoxicity of nano-TiO2 and GNP for both species existed, though compared with nano-TiO2, GNP had a 2.3-fold increase in visible light photocatalytic ROS generation. In summary, this study demonstrated the significance of illumination spectrum, particle behavior, and species sensitivity on nanophototoxicity, and the needs for research on increasingly sophisticated functional materials. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Li, Shibin; Wallis, Lindsay K.] US Environm Protect Agcy, Off Res & Dev, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
[Pan, Xuan; Fan, Zhaoyang] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA.
[Pan, Xuan; Fan, Zhaoyang] Texas Tech Univ, Nano Tech Ctr, Lubbock, TX 79409 USA.
[Chen, ZuLiang] Fujian Normal Univ, Sch Chem & Mat Sci, Fuzhou 350007, Fujian, Peoples R China.
[Diamond, Stephen A.] Nanosafe Inc, Blacksburg, VA USA.
RP Li, SB (reprint author), US Environm Protect Agcy, Off Res & Dev, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
EM li.shibin@epa.gov
RI Pan, Xuan/K-8545-2014; Geracitano, Laura/E-6926-2013
OI Pan, Xuan/0000-0002-7770-7974;
FU National Research Council Research Associateship Award at the U.S.
Environmental Protection Agency, Mid-Continent Ecology Division
FX The present study was performed while one of the authors, S. Li, held a
National Research Council Research Associateship Award at the U.S.
Environmental Protection Agency, Mid-Continent Ecology Division. This
document has been subjected to review by the National Health and
Environmental Effects Research Laboratory and approved for publication.
Approval does not signify that the contents reflect the views of the
Agency nor does mention of trade names or commercial products constitute
endorsement or recommendation for use.
NR 36
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U2 216
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD OCT
PY 2014
VL 112
BP 62
EP 69
DI 10.1016/j.chemosphere.2014.03.058
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AN6ES
UT WOS:000340688300009
PM 25048889
ER
PT J
AU Christopoulos, A
Changeux, JP
Catterall, WA
Fabbro, D
Burris, TP
Cidlowski, JA
Olsen, RW
Peters, JA
Neubig, RR
Pin, JP
Sexton, PM
Kenakin, TP
Ehlert, FJ
Spedding, M
Langmead, CJ
AF Christopoulos, Arthur
Changeux, Jean-Pierre
Catterall, William A.
Fabbro, Doriano
Burris, Thomas P.
Cidlowski, John A.
Olsen, Richard W.
Peters, John A.
Neubig, Richard R.
Pin, Jean-Philippe
Sexton, Patrick M.
Kenakin, Terry P.
Ehlert, Frederick J.
Spedding, Michael
Langmead, Christopher J.
TI International Union of Basic and Clinical Pharmacology. XC. Multisite
Pharmacology: Recommendations for the Nomenclature of Receptor
Allosterism and Allosteric Ligands
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID PROTEIN-COUPLED RECEPTORS; GATED ION CHANNELS; NICOTINIC
ACETYLCHOLINE-RECEPTORS; THYROID-HORMONE RECEPTOR; GATING MODIFIER
TOXINS; NEURONAL CALCIUM-CHANNEL; AMINO-ACID SUBSTITUTIONS; MULTIPLE
BINDING-SITES; GROWTH-FACTOR RECEPTOR; NUCLEAR-RECEPTOR
AB Allosteric interactions play vital roles in metabolic processes and signal transduction and, more recently, have become the focus of numerous pharmacological studies because of the potential for discovering more target-selective chemical probes and therapeutic agents. In addition to classic early studies on enzymes, there are now examples of small molecule allosteric modulators for all superfamilies of receptors encoded by the genome, including ligand-and voltage-gated ion channels, G protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases. As a consequence, a vast array of pharmacologic behaviors has been ascribed to allosteric ligands that can vary in a target-, ligand-, and cell-/tissue-dependent manner. The current article presents an overview of allostery as applied to receptor families and approaches for detecting and validating allosteric interactions and gives recommendations for the nomenclature of allosteric ligands and their properties.
C1 [Christopoulos, Arthur; Sexton, Patrick M.; Langmead, Christopher J.] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia.
[Christopoulos, Arthur; Sexton, Patrick M.; Langmead, Christopher J.] Monash Univ, Monash Inst Pharmaceut Sci, Dept Pharmacol, Parkville, Vic 3052, Australia.
[Changeux, Jean-Pierre] Inst Pasteur, Coll France, Paris, France.
[Changeux, Jean-Pierre] Inst Pasteur, CNRS URA 2182, Paris, France.
[Catterall, William A.] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA USA.
[Fabbro, Doriano] PIQUR Therapeut AG, Basel, Switzerland.
[Burris, Thomas P.] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, LA 63103 USA.
[Cidlowski, John A.] Natl Inst Environm Hlth Sci, Mol Endocrinol Grp, Signal Transduct Lab, Res Triangle Pk, NC USA.
Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA USA.
[Pin, Jean-Philippe] Univ Dundee, Sch Med, Div Neurosci, Dundee DD1 4HN, Scotland.
[Neubig, Richard R.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
[Pin, Jean-Philippe] CNRS, Inst Genom Fonct, Montpellier, France.
[Kenakin, Terry P.] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA.
[Ehlert, Frederick J.] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA.
[Spedding, Michael] Res Solut SARL, Paris, France.
RP Christopoulos, A (reprint author), Monash Univ, Monash Inst Pharmaceut Sci, 399 Royal Parade, Parkville, Vic 3052, Australia.
EM arthur.christopoulos@monash.edu
RI Burris, Thomas/B-3886-2016; Sexton, Patrick/B-1319-2008;
OI Burris, Thomas/0000-0003-2922-4449; Sexton, Patrick/0000-0001-8902-2473;
Spedding, Michael/0000-0002-1248-8221; Christopoulos,
Arthur/0000-0003-4442-3294
NR 302
TC 51
Z9 51
U1 3
U2 36
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
EI 1521-0081
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD OCT
PY 2014
VL 66
IS 4
BP 918
EP 947
DI 10.1124/pr.114.008862
PG 30
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AN8YQ
UT WOS:000340892400001
PM 25026896
ER
PT J
AU Szabo, JG
Adcock, NJ
Rice, EW
AF Szabo, Jeffrey G.
Adcock, Noreen J.
Rice, Eugene W.
TI Disinfection of Bacillus spores with acidified nitrite
SO CHEMOSPHERE
LA English
DT Article
DE Disinfection; Acidified nitrite; Bacillus; Spores; Contamination;
Drinking water
ID PSEUDOMONAS-AERUGINOSA; CHLORINE DIOXIDE; INACTIVATION; ANTHRACIS;
AGENTS; OXIDE; GLOBIGII; WATER; DECONTAMINATION; MONOCHLORAMINE
AB Disinfecting water generated from a bioterrorism contamination event will require large amounts of disinfectant since the volume of water flushed from a drinking water distribution system or wash water collected from a contaminated outdoor area can accumulate quickly. Commonly used disinfectants may be unavailable in the necessary amounts, so evaluation of alternative disinfectants is needed. This study focuses on disinfection of Bacillus spores in water using acidified nitrite. The effect of varying pH (2 or 3), temperature (5 degrees C or 24 degrees C), nitrite concentration (0.01 or 0.1 M), buffer (Butterfields or Phosphate Buffered Saline, PBS) and Bacillus species (B. globigii and B. anthracis Sterne) was evaluated. B. globigii was more resistant to disinfection under all water quality conditions. Disinfection was more effective for B. globigii and B. anthracis Sterne at 0.1 M nitrite, pH 2, and 24 degrees C. Disinfection of B. anthracis Sterne was enhanced in low ionic strength Butterfields buffer compared to PBS. Published by Elsevier Ltd.
C1 [Szabo, Jeffrey G.; Rice, Eugene W.] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
[Adcock, Noreen J.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA.
RP Szabo, JG (reprint author), US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
EM szabo.jeff@epa.gov
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and conducted this research. It has been subject
to an administrative review but does not necessarily reflect the views
of the Agency. EPA does not endorse the purchase or sale of any
commercial products or services.
NR 29
TC 2
Z9 2
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD OCT
PY 2014
VL 113
BP 171
EP 174
DI 10.1016/j.chemosphere.2014.05.038
PG 4
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AN1IF
UT WOS:000340335200025
PM 25065806
ER
PT J
AU Maynard, JJ
Johnson, MG
AF Maynard, J. J.
Johnson, M. G.
TI Scale-dependency of LiDAR derived terrain attributes in quantitative
soil-landscape modeling: Effects of grid resolution vs. neighborhood
extent
SO GEODERMA
LA English
DT Article
DE LiDAR; Digital elevation model; Grid resolution; Neighborhood extent;
Scale effects; Terrain attributes; Soil landscape modeling
ID SPATIAL PREDICTION; ENVIRONMENTAL CORRELATION; DEPTH FUNCTIONS; CARBON
STORAGE; DEM RESOLUTION; IDENTIFICATION; VARIABILITY; PARAMETERS; SIZE
AB Quantifying the spatial distribution of soil properties is essential for ecological and environmental modeling at the landscape scale. Terrain attributes are among the primary covariates in soil-landscape models due to their control on energy and mass fluxes, which in turn control the spatial distribution of soil properties and processes. While numerous studies have demonstrated the importance of terrain attributes for predicting landscape-scale soil variability, considerable uncertainty exists as to the scale-dependency of light detection and ranging (LiDAR) derived terrain attributes on the accuracy of soil-landscape model predictions. Thirty five pedons were sampled by genetic horizon in a 2300 ha forested watershed and three soil properties (clay, sum of bases, and total carbon), representing dominant pedogenic processes within the watershed were analyzed. Soil properties were used as dependent variables and terrain attributes, calculated from LiDAR derived DEMs of various grid resolutions (ranging from 5 to 50 m) and neighborhood extents (ranging from 15 to 350 m), were used as predictor variables in ordinary least-squares (OLS) regression models. Results from this study show that model predictions exhibit a strong scale-dependency, with percent clay, sum of bases, and total carbon having the highest R-2-adj and lowest root mean square error (RMSE) at coarse neighborhood extents (i.e., 150 to 300 m) both between soil variables and across soil depths. Furthermore, in certain instances grid resolution was also shown to affect soil-terrain correlations, although to a lesser degree than neighborhood extent. In many cases fine to moderate scale grid resolutions (i.e.,<30 m) more accurately represented terrain features, resulting in higher correlations to soil properties at fixed neighborhood extents relative to course grid resolutions. Additionally, these results show that fine scale topographic information (i.e., 1 to 5 m) does not necessarily provide a stronger predictor of soil spatial variability relative to moderate scale information. This study provides a robust framework for investigating pedogeomorphological processes on a landscape scale through examination of the scale dependency of modeled terrain attributes in quantitative soil-landscape modeling. Published by Elsevier B.V.
C1 [Maynard, J. J.] USDA ARS, Las Cruces, NM 88003 USA.
[Johnson, M. G.] US EPA, Corvallis, OR 97333 USA.
RP Maynard, JJ (reprint author), USDA ARS, POB 30003,MSC 3JER, Las Cruces, NM 88003 USA.
EM jmaynard@nmsu.com
FU U.S. Environmental Protection Agency; United States Department of
Agriculture-Agricultural Research Service
FX The information in this document has been funded in part by the U.S.
Environmental Protection Agency and the United States Department of
Agriculture-Agricultural Research Service. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory's Western Ecology Division and approved for publication.
Approval does not signify that the contents reflect the views of the
Agencies, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 37
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Z9 9
U1 1
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0016-7061
EI 1872-6259
J9 GEODERMA
JI Geoderma
PD OCT
PY 2014
VL 230
BP 29
EP 40
DI 10.1016/j.geoderma.2014.03.021
PG 12
WC Soil Science
SC Agriculture
GA AL0KX
UT WOS:000338816900004
ER
PT J
AU Kim, K
Whelan, G
Purucker, ST
Bohrmann, TF
Cyterski, MJ
Molina, M
Gu, Y
Pachepsky, Y
Guber, A
Franklin, DH
AF Kim, Keewook
Whelan, Gene
Purucker, S. Thomas
Bohrmann, Thomas F.
Cyterski, Michael J.
Molina, Marirosa
Gu, Yin
Pachepsky, Yakov
Guber, Andrey
Franklin, Dorcas H.
TI Rainfall-runoff model parameter estimation and uncertainty evaluation on
small plots
SO HYDROLOGICAL PROCESSES
LA English
DT Article
DE watershed modeling; inverse modeling; bootstrap; PEST; KINEROS2; STWIR
ID CALIBRATION; SIMULATION; BOOTSTRAP; FRAMEWORK; SURFACE
AB Four seasonal rainfall simulations in 2009 and 2010 were applied to a field containing 36 plots (0.75x2m each), resulting in 144 runoff events. In all simulations, a constant rate of rainfall was applied then halted 60min after initiation of runoff, with plot-scale monitoring of runoff every 5min during that period. Runoff was simulated with the Kinematic Runoff and Erosion/Simulator of Transport with Infiltration and Runoff (KINEROS2/STWIR) field-scale model, whose hydrodynamics are based on the kinematic wave equation. Because of the non-linear nature of the model and a highly parameterized model with respect to the available data, several approaches were investigated to upscale nine runoff-related parameters from a series of small monitored plots to the field scale. Inverse modeling was performed using the model-independent Parameter ESTimation (PEST) algorithm to individually calibrate the nine KINEROS2/STWIR parameters on 36 plots. The parameters were averaged, and bootstrapping was used to assess uncertainty of the parameters via estimation of confidence intervals (CI). A Monte Carlo simulation using the bootstrap results showed reasonable field-scale representation of flow rates. Median values of calibrated parameters were within the 95% CI obtained with bootstrapping. The simulated results for the median values associated with the 90% CI flow rates produced similar trends as those exhibited with the observed data, suggesting that median values of the calibrated parameters from the PEST inverse modeling could be used to represent the field scale. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Kim, Keewook; Whelan, Gene; Purucker, S. Thomas; Bohrmann, Thomas F.; Cyterski, Michael J.; Molina, Marirosa; Gu, Yin] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Kim, Keewook] US DOE, Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA.
[Bohrmann, Thomas F.] Cardno ENTRIX, Raleigh, NC 27612 USA.
[Pachepsky, Yakov] ARS, Environm Microbial & Food Safety Lab, USDA, Beltsville, MD 20705 USA.
[Guber, Andrey] Michigan State Univ, Dept Plant Soil & Microbial Sci, East Lancing, MI 48824 USA.
[Franklin, Dorcas H.] Univ Georgia, USDA ARS, Athens, GA 30602 USA.
[Franklin, Dorcas H.] Univ Georgia, Dept Crop & Soil Sci, Athens, GA 30602 USA.
RP Kim, K (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
EM kim.keewook@epa.gov
OI Kim, Keewook/0000-0002-6625-7285; Pachepsky, Yakov/0000-0003-0232-6090
FU Research Participation Program at the US Environmental Protection
Agency, Office of Research and Development [DW8992298301]; Student
Services Contracting Authority; US Environmental Protection Agency
through its Office of Research and Development
FX This research was supported in part by an appointment to the Research
Participation Program at the US Environmental Protection Agency, Office
of Research and Development, administered by the Oak Ridge Institute for
Science and Education through Interagency Agreement No. DW8992298301
between the US Department of Energy and the US Environmental Protection
Agency. The Richard B. Russell Agricultural Research Center,
Agricultural Research Service, US Department of Agriculture, in Athens,
GA provided technical assistance on the field work. Data collection and
collation services were provided by students under contract with the
Student Services Contracting Authority. The US Environmental Protection
Agency through its Office of Research and Development funded and managed
the research described here. It has been subjected to Agency review and
approved for publication.
NR 45
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Z9 7
U1 4
U2 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6087
EI 1099-1085
J9 HYDROL PROCESS
JI Hydrol. Process.
PD SEP 30
PY 2014
VL 28
IS 20
BP 5220
EP 5235
DI 10.1002/hyp.10001
PG 16
WC Water Resources
SC Water Resources
GA AP2ER
UT WOS:000341885800008
ER
PT J
AU Hsu, CW
Zhao, JH
Huang, RL
Hsieh, JH
Hamm, J
Chang, XQ
Houck, K
Xia, MH
AF Hsu, Chia-Wen
Zhao, Jinghua
Huang, Ruili
Hsieh, Jui-Hua
Hamm, Jon
Chang, Xiaoqing
Houck, Keith
Xia, Menghang
TI Quantitative High-Throughput Profiling of Environmental Chemicals and
Drugs that Modulate Farnesoid X Receptor
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BILE-ACID-BINDING; NUCLEAR RECEPTOR; BETA-TUBULIN; NATURAL-PRODUCT;
CANCER CELLS; FXR; ANTAGONIST; LIGAND; IDENTIFICATION; EXPRESSION
AB The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR beta-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals and drugs. Structure-activity relationships of FXR-active compounds revealed by this screening were then compared against the androgen receptor, estrogen receptor alpha, peroxisome proliferator-activated receptors delta and gamma, and the vitamin D receptor. We identified several FXR-active structural classes including anthracyclines, benzimidazoles, dihydropyridines, pyrethroids, retinoic acids, and vinca alkaloids. Microtubule inhibitors potently decreased FXR reporter gene activity. Pyrethroids specifically antagonized FXR transactivation. Anthracyclines affected reporter activity in all tested assays, suggesting non-specific activity. These results provide important information to prioritize chemicals for further investigation, and suggest possible modes of action of compounds in FXR signaling.
C1 [Hsu, Chia-Wen; Zhao, Jinghua; Huang, Ruili; Xia, Menghang] NIH, Natl Ctr Advancing Translat Sci, Bethesda, MD 20892 USA.
[Hsieh, Jui-Hua] NIEHS, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA.
[Hamm, Jon; Chang, Xiaoqing] Integrated Lab Syst Inc, Morrisville, NC USA.
[Houck, Keith] US EPA, Res Triangle Pk, NC 27711 USA.
RP Xia, MH (reprint author), NIH, Natl Ctr Advancing Translat Sci, Bldg 10, Bethesda, MD 20892 USA.
EM mxia@mail.nih.gov
FU U.S. Environmental Protection Agency [Y3-HG-7026-03]; National
Toxicology Program [Y2-ES-7020-01]
FX This work was supported by the U.S. Environmental Protection Agency
(Interagency agreement #Y3-HG-7026-03) and the National Toxicology
Program (Interagency agreement #Y2-ES-7020-01). We thank Misha Itkin,
Danielle VanLeer, Paul Shinn for compound management, Tongan Zhao for
informatics support, and Sam Michael for technical support of the
screening process. We also thank Dave Allen, Kevin Crofton, Raymond
Tice, and Stephen Ferguson for reviewing the manuscript. The views
expressed in this paper are those of the authors and do not necessarily
reflect the statements, opinions, views, conclusions, or policies of the
National Institute of Environmental Health Sciences (NIEHS), the U.S.
Environmental Protection Agency, the National Center for Advancing
Translational Sciences (NCATS), National Institutes of Health (NIH), or
the United States government.
NR 77
TC 7
Z9 7
U1 4
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 26
PY 2014
VL 4
AR 6437
DI 10.1038/srep06437
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AP8WY
UT WOS:000342361300001
PM 25257666
ER
PT J
AU Sagarika, S
Kalra, A
Ahmad, S
AF Sagarika, Soumya
Kalra, Ajay
Ahmad, Sajjad
TI Evaluating the effect of persistence on long-term trends and analyzing
step changes in streamflows of the continental United States
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Streamflow; Trend detection; Shift; Persistence; Climate variability
ID SURFACE BACKSCATTER RESPONSE; PACIFIC DECADAL OSCILLATION; TRMM
PRECIPITATION RADAR; COLORADO RIVER-BASIN; CLIMATE-CHANGE;
SOIL-MOISTURE; WATER-RESOURCES; MANN-KENDALL; CARBON FOOTPRINT; HURST
PHENOMENON
AB Streamflow is a very good indicator of long-term hydroclimatic changes. From a water management perspective, the identification of gradual (trend) and abrupt (shift) changes in streamflow are important for planning purposes. This study investigated the detection of comprehensive change, gradual and abrupt, in 240 unimpaired streamflow stations, categorized according to the hydrologic regions in the continental United States. The changes in streamflow volume were analyzed for water-year, autumn, winter, spring, and summer from 1951 to 2010, a 60-year period. The non-parametric Mann-Kendall test, with variations accounting for short term and long-term persistence, was used to evaluate the trends; the non-parametric change-point Pettitt test was used to evaluate the shifts. The field significance was evaluated using the Walker test. The trend results indicated increasing streamflow patterns in the majority of the eastern U.S. regions - the Upper Mississippi, Missouri, Great Lakes and Texas Gulf were field significant - and dominant decreasing streamflow trends in the Pacific Northwest region. The use of different Mann-Kendall test helped in evaluating the spatial distribution of short-term and long-term persistence and their effect on trends. The Pettitt test analysis indicated that statistically significant shifts occurred during the early 1970s and late 1980s. Similar to the trend results, the Midwest as well as the central and southern U.S. had significantly increasing shifts; the Pacific Northwest, Tennessee (winter season only), and South-Atlantic Gulf (spring season only) had decreasing shifts in streamflow. The findings may assist water managers in better planning and management of water resources under climate variability and change. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sagarika, Soumya; Ahmad, Sajjad] Univ Nevada, Dept Civil & Environm Engn & Construct, Las Vegas, NV 89154 USA.
[Kalra, Ajay] US EPA, ORD, NERL, ESD,Landscape Ecol Branch, Las Vegas, NV 89119 USA.
RP Ahmad, S (reprint author), Univ Nevada, Dept Civil & Environm Engn & Construct, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA.
EM sajjad.ahmad@unlv.edu
RI Ahmad, Sajjad/A-2867-2008;
OI Ahmad, Sajjad/0000-0002-9903-9321; Kalra, Ajay/0000-0003-3878-2346
FU NSF [EPS-0814372, CMMI-0846952]
FX This work is partly supported by NSF under Grants EPS-0814372 and
CMMI-0846952.
NR 108
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Z9 28
U1 2
U2 55
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD SEP 19
PY 2014
VL 517
BP 36
EP 53
DI 10.1016/j.jhydrol.2014.05.002
PG 18
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AO0CP
UT WOS:000340977000004
ER
PT J
AU Patil, SD
Wigington, PJ
Leibowitz, SG
Sproles, EA
Comeleo, RL
AF Patil, Sopan D.
Wigington, Parker J., Jr.
Leibowitz, Scott G.
Sproles, Eric A.
Comeleo, Randy L.
TI How does spatial variability of climate affect catchment streamflow
predictions?
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Hydrologic model; Climate variability; Streamflow; Catchment
ID WESTERN UNITED-STATES; RAINFALL VARIABILITY; HYDROLOGICAL MODELS;
PACIFIC-NORTHWEST; WATERSHED MODELS; IMPACT; RUNOFF; PRECIPITATION;
EFFICIENCY; SNOWPACK
AB Spatial variability of climate can negatively affect catchment streamflow predictions if it is not explicitly accounted for in hydrologic models. In this paper, we examine the changes in streamflow predictability when a hydrologic model is run with spatially variable (distributed) meteorological inputs instead of spatially uniform (lumped) meteorological inputs. Both lumped and distributed versions of the EXP-HYDRO model are implemented at 41 meso-scale (500-5000 km(2)) catchments in the Pacific Northwest region of USA. We use two complementary metrics of long-term spatial climate variability, moisture homogeneity index (I-M) and temperature variability index (I-TV), to analyze the performance improvement with distributed model. Results show that the distributed model performs better than the lumped model in 38 out of 41 catchments, and noticeably better (>10% improvement) in 13 catchments. Furthermore, spatial variability of moisture distribution alone is insufficient to explain the observed patterns of model performance improvement. For catchments with low moisture homogeneity (I-M < 80%), I-M is a better predictor of model performance improvement than I-TV; whereas for catchments with high moisture homogeneity (I-M> 80%), I-TV is a better predictor of performance improvement than I-M. Based on the results, we conclude that: (1) catchments that have low homogeneity of moisture distribution are the obvious candidates for using spatially distributed meteorological inputs, and (2) catchments with a homogeneous moisture distribution benefit from spatially distributed meteorological inputs if they also have high spatial variability of precipitation phase (rain vs. snow). (C) 2014 Elsevier B.V. All rights reserved.
C1 [Patil, Sopan D.; Sproles, Eric A.] US EPA, ORISE, Corvallis, OR 97333 USA.
[Patil, Sopan D.] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor LL57 2UW, Gwynedd, Wales.
[Wigington, Parker J., Jr.; Leibowitz, Scott G.; Comeleo, Randy L.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Sproles, Eric A.] Univ La Serena, Ctr Estudios Avanzados Zonas Aridas, La Serena, Chile.
RP Patil, SD (reprint author), Bangor Univ, Sch Environm Nat Resources & Geog, Deiniol Rd, Bangor LL57 2UW, Gwynedd, Wales.
EM s.d.patil@bangor.ac.uk
RI Patil, Sopan/E-8497-2011;
OI Patil, Sopan/0000-0002-8575-5220; Sproles, Eric/0000-0003-1245-1653
FU ORISE; U.S. Environmental Protection Agency
FX We are thankful to J. Renee Brooks, Stacey Archfield, Marc Stieglitz,
and two anonymous reviewers for valuable comments and suggestions that
have greatly improved the paper. The first (Patil) and the fourth
(Sproles) authors were supported by ORISE postdoctoral fellowship for
the duration of this study. The information in this document has been
funded entirely by the U.S. Environmental Protection Agency. This
manuscript has been subjected to Agency review and has been approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 55
TC 2
Z9 2
U1 2
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD SEP 19
PY 2014
VL 517
BP 135
EP 145
DI 10.1016/j.jhydrol.2014.05.017
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AO0CP
UT WOS:000340977000012
ER
PT J
AU Upadhyay, S
Stoeger, T
George, L
Schladweiler, MC
Kodavanti, U
Ganguly, K
Schulz, H
AF Upadhyay, Swapna
Stoeger, Tobias
George, Leema
Schladweiler, Mette C.
Kodavanti, Urmila
Ganguly, Koustav
Schulz, Holger
TI Ultrafine carbon particle mediated cardiovascular impairment of aged
spontaneously hypertensive rats
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
DE Inflammation; Lung; Heart; Dust; Particle exposure; Cardiovascular risk
individuals
ID COMBUSTION-DERIVED NANOPARTICLES; AMERICAN-HEART-ASSOCIATION;
PARTICULATE AIR-POLLUTION; INTRATRACHEAL INSTILLATION; SURFACE-AREA;
PULMONARY INFLAMMATION; OXIDATIVE STRESS; RATE-VARIABILITY;
LUNG-FUNCTION; TISSUE FACTOR
AB Background: Studies provide compelling evidences for particulate matter (PM) associated cardiovascular health effects. Elderly individuals, particularly those with preexisting conditions like hypertension are regarded to be vulnerable. Experimental data are warranted to reveal the molecular pathomechanism of PM related cardiovascular impairments among aged/predisposed individuals. Thus we investigated the cardiovascular effects of ultrafine carbon particles (UfCP) on aged (12-13 months) spontaneously hypertensive rats (SHRs) and compared the findings with our pervious study on adult SHRs (6-7 months) to identify age related predisposition events in cardiovascular compromised elderly individuals.
Methods: Aged SHRs were inhalation exposed to UfCP for 24 h (similar to 180 mu g/m(3)) followed by radio-telemetric assessment for blood pressure (BP) and heart rate (HR). Bronchoalveolar lavage (BAL) fluid cell differentials, interleukin 6 (IL-6) and other proinflammatory cytokines; serum C-reactive protein (CRP) and haptoglobin (HPT); and plasma fibrinogen were measured. Transcript levels of hemeoxygenase 1 (HO-1), endothelin 1 (ET1), endothelin receptors A, B (ETA, ETB), tissue factor (TF), and plasminogen activator inhibitor-1 (PAI-1) were measured in the lung and heart to assess oxidative stress, endothelial dysfunction and coagulation cascade.
Result: UfCP exposed aged SHRs exhibited increased BP (4.4%) and HR (6.3%) on 1st recovery day paralleled by a 58% increase of neutrophils and 25% increase of IL-6 in the BAL fluid. Simultaneously higher CRP, HPT and fibrinogen levels in exposed SHRs indicate systemic inflammation. HO-1, ET1, ET-A, ET-B, TF and PAI-1 were induced by 1.5-2.0 folds in lungs of aged SHRs on 1st recovery day. However, in UfCP exposed adult SHRs these markers were up-regulated (2.5-6 fold) on 3rd recovery day in lung without detectable pulmonary/systemic inflammation.
Conclusions: The UfCP induced pulmonary and systemic inflammation in aged SHRs is associated with oxidative stress, endothelial dysfunction and disturbed coagulatory hemostasis. UfCP exposure increased BP and HR in aged SHRs rats which was associated with lung inflammation, and increased expression of inflammatory, vasoconstriction and coagulation markers as well as systemic changes in biomarkers of thrombosis in aged SHRs. Our study provides further evidence for potential molecular mechanisms explaining the increased risk of particle mediated cardiac health effects in cardiovascular compromised elderly individuals.
C1 [Upadhyay, Swapna; Stoeger, Tobias; Ganguly, Koustav; Schulz, Holger] German Res Ctr Environm Hlth, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Helmholtz Zentrum Munchen, Munich, Germany.
[Upadhyay, Swapna] Indian Inst Technol, Dept Biotechnol, Madras 600036, Tamil Nadu, India.
[George, Leema; Ganguly, Koustav] SRM Univ, SRM Res Inst, Madras 603203, Tamil Nadu, India.
[Schladweiler, Mette C.; Kodavanti, Urmila] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
[Schulz, Holger] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, D-85764 Neuherberg, Germany.
RP Upadhyay, S (reprint author), German Res Ctr Environm Hlth, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Helmholtz Zentrum Munchen, Munich, Germany.
EM swapnaupadhyay@gmail.com; schulz@helmholtz-muenchen.de
RI Stoger, Tobias/M-9861-2014; Schulz, Holger/J-5643-2015
OI Stoger, Tobias/0000-0002-2790-0389; Schulz, Holger/0000-0002-1157-200X
FU Council for Scientific and Industrial Research (CSIR); Government of
India [CSIR-SRA] [(13-8553A)-2012/POOL]
FX [SU] Council for Scientific and Industrial Research (CSIR); Government
of India [Reference: CSIR-SRA (13-8553A)-2012/POOL].
NR 86
TC 4
Z9 4
U1 2
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD SEP 17
PY 2014
VL 11
AR 36
DI 10.1186/s12989-014-0036-6
PG 18
WC Toxicology
SC Toxicology
GA AU8SX
UT WOS:000345867800001
PM 25442699
ER
PT J
AU Wagstrom, KM
Baker, KR
Leinbach, AE
Hunt, SW
AF Wagstrom, Kristina M.
Baker, Kirk R.
Leinbach, Alan E.
Hunt, Sherri W.
TI Synthesizing Scientific Progress: Outcomes from US EPA's Carbonaceous
Aerosols and Source Apportionment STAR Grants
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; POLYCYCLIC AROMATIC-HYDROCARBONS; POSITIVE
MATRIX FACTORIZATION; URBAN SUPERSITE T0; MASS-SPECTROMETRY;
HIGH-RESOLUTION; MOLECULAR MARKERS; VOLATILITY MEASUREMENTS;
AIR-POLLUTION; UNITED-STATES
AB In response to recommendations by the National Research Council in the late 1990s and early 2000s for critical research into understanding sources and formation mechanisms of PM2.5, EPA created multiple funding opportunities through the Science to Achieve Results (STAR) program: Measurement, Modeling, and Analysis Methods for Airborne Carbonaceous Fine Particulate Matter (2003) and Source Apportionment of Particulate Matter (2004). The carbonaceous fine PM solicitation resulted in 16 different projects focusing on the measurement methods, source identification, and exploration of the chemical and physical processes important for PM2.5 carbon in the atmosphere. The source apportionment funding opportunity led to 11 projects improving tools and characterization of source-receptor relationships of PM2.5. Many funding mechanisms include a final synopsis of funded research and published manuscripts. Here, this evaluation is extended to include citations of research published as part of these solicitations. These solicitations resulted in 275 publications that included more than 850 unique authors in 37 different journals with a weighted average 2011 impact factor of 4.21. At the time of this assessment, these publications have been cited by 13 612 peer review journal articles with 31 (11%) of the manuscripts being cited over 100 times.
C1 [Wagstrom, Kristina M.] Univ Connecticut, Storrs, CT 06269 USA.
[Wagstrom, Kristina M.] US EPA, Washington, DC 20460 USA.
[Baker, Kirk R.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27709 USA.
[Leinbach, Alan E.; Hunt, Sherri W.] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA.
RP Hunt, SW (reprint author), US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA.
EM hunt.sherri@epa.gov
NR 139
TC 1
Z9 1
U1 1
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 16
PY 2014
VL 48
IS 18
BP 10561
EP 10570
DI 10.1021/es500782k
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP1BN
UT WOS:000341801500006
PM 25111572
ER
PT J
AU Rappold, AG
Fann, NL
Crooks, J
Huang, J
Cascio, WE
Devlin, RB
Diaz-Sanchez, D
AF Rappold, Ana G.
Fann, Neal L.
Crooks, James
Huang, Jin
Cascio, Wayne E.
Devlin, Robert B.
Diaz-Sanchez, David
TI Forecast-Based Interventions Can Reduce the Health and Economic Burden
of Wildfires
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID EMERGENCY-DEPARTMENT VISITS; AIR-POLLUTION; DIFFERENTIAL VULNERABILITY;
HOSPITAL ADMISSIONS; RISK-ASSESSMENT; SMOKE EXPOSURE; NORTH-CAROLINA;
FOREST-FIRES; MORTALITY; ASTHMA
AB We simulated public health forecast-based interventions during a wildfire smoke episode in rural North Carolina to show the potential for use of modeled smoke forecasts toward reducing the health burden and showed a significant economic benefit of reducing exposures. Daily and county wide intervention advisories were designed to occur when fine particulate matter (PM2.5) from smoke, forecasted 24 or 48 h in advance, was expected to exceed a predetermined threshold. Three different thresholds were considered in simulations, each with three different levels of adherence to the advisories. Interventions were simulated in the adult population susceptible to health exacerbations related to the chronic conditions of asthma and congestive heart failure. Associations between Emergency Department (ED) visits for these conditions and daily PM2.5 concentrations under each intervention were evaluated. Triggering interventions at lower PM2.5 thresholds (<= 20 mu g/m(3)) with good compliance yielded the greatest risk reduction. At the highest threshold levels (50 mu g/m(3)) interventions were ineffective in reducing health risks at any level of compliance. The economic benefit of effective interventions exceeded $1 M in excess ED visits for asthma and heart failure, $2 M in loss of productivity, $100 K in respiratory conditions in children, and $42 million due to excess mortality.
C1 [Rappold, Ana G.; Crooks, James; Cascio, Wayne E.; Devlin, Robert B.; Diaz-Sanchez, David] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Fann, Neal L.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Huang, Jin] ABT Associates Inc, Environm & Resources Div, Bethesda, MD 20814 USA.
RP Rappold, AG (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, MB 58B,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Rappold.ana@epa.gov
NR 29
TC 5
Z9 5
U1 3
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 16
PY 2014
VL 48
IS 18
BP 10571
EP 10579
DI 10.1021/es5012725
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP1BN
UT WOS:000341801500007
PM 25123711
ER
PT J
AU Gantt, B
Hoque, S
Willis, RD
Fahey, KM
Delgado-Saborit, JM
Harrison, RM
Erdakos, GB
Bhave, PV
Zhang, KM
Kovalcik, K
Pye, HOT
AF Gantt, Brett
Hoque, Shamia
Willis, Robert D.
Fahey, Kathleen M.
Delgado-Saborit, Juana Mari
Harrison, Roy M.
Erdakos, Garnet B.
Bhave, Prakash V.
Zhang, K. Max
Kovalcik, Kasey
Pye, Havala O. T.
TI Near-Road Modeling and Measurement of Cerium-Containing Particles
Generated by Nanoparticle Diesel Fuel Additive Use
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID OXIDE NANOPARTICLES; ENDOMYOCARDIAL FIBROSIS; ULTRAFINE PARTICLES;
NUMBER-DISTRIBUTION; ENGINE; CELLS; SIZE; PARTICULATE; EVOLUTION;
EMISSIONS
AB Cerium oxide nanoparticles (nCe) are used as a fuel-borne catalyst in diesel engines to reduce particulate emissions, yet the environmental and human health impacts of the exhaust particles are not well understood. To bridge the gap between emission measurements and ambient impacts, size-resolved measurements of particle composition and mass concentration have been performed in Newcastle-upon-Tyne, United Kingdom, where buses have used an nCe additive since 2005. These observations show that the noncrustal cerium fraction thought to be associated with the use of nCe has a mass concentration ?0.3 ng m3 with a size distribution peaking at 100320 nm in aerodynamic diameter. Simulations with a near-roadway multicomponent sectional aerosol dynamic model predict that the use of nCe additives increases the number concentration of nuclei mode particles (<50 nm in diameter) while decreasing the total mass concentration. The near-road model predicts a downwind mass size distribution of cerium-containing particles peaking at 150 nm in aerodynamic diameter, a value similar to that measured for noncrustal cerium in Newcastle. This work shows that both the emission and atmospheric transformation of cerium-containing particles needs to be taken into account by regional modelers, exposure scientists, and policymakers when determining potential environmental and human health impacts.
C1 [Gantt, Brett; Hoque, Shamia; Willis, Robert D.; Fahey, Kathleen M.; Erdakos, Garnet B.; Bhave, Prakash V.; Kovalcik, Kasey; Pye, Havala O. T.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Delgado-Saborit, Juana Mari; Harrison, Roy M.] Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England.
[Harrison, Roy M.] King Abdulaziz Univ, Ctr Excellence Environm Studies, Dept Environm Sci, Jeddah 21589, Saudi Arabia.
[Zhang, K. Max] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA.
RP Gantt, B (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM brett@epa.gov; pye.havala@epa.gov
RI Harrison, Roy/A-2256-2008; Gantt, Brett/G-2525-2013; Delgado-Saborit,
Juana Maria/I-4158-2015; Pye, Havala/F-5392-2012; Delgado-Saborit, Juana
Maria/A-5057-2017
OI Harrison, Roy/0000-0002-2684-5226; Gantt, Brett/0000-0001-7217-2715;
Delgado-Saborit, Juana Maria/0000-0002-7096-9744; Pye,
Havala/0000-0002-2014-2140; Delgado-Saborit, Juana
Maria/0000-0002-7096-9744
FU United States Environmental Protection Agency (EPA) through its Office
of Research and Development
FX We acknowledge use of monitor data from the U.K. Department for
Environment, Food and Rural Affairs Automatic Urban and Rural Network;
Crown 2014 copyright Defra via uk-air.defra.gov.uk, licenced under the
Open Government Licence (OGL). The United States Environmental
Protection Agency (EPA) through its Office of Research and Development
funded and managed the research described here. This paper has been
subjected to the Agency's administrative review and approved for
publication. B.G. and S.H. are supported by an appointment to the
Research Participation Program at the Office of Research and
Development, U.S. EPA, administered by ORISE. We also acknowledge
Eastern Research Group (ERG, including Richard Billings and Joe Fanjoy)
and William Benjey for their administrative input. In addition, we would
like to thank AEA Technology, including Geoff Dollard and Steve Telling,
for sampler operation.
NR 34
TC 9
Z9 9
U1 7
U2 32
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 16
PY 2014
VL 48
IS 18
BP 10607
EP 10613
DI 10.1021/es502169p
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP1BN
UT WOS:000341801500011
PM 25144365
ER
PT J
AU Wang, H
Proctor, CR
Edwards, MA
Pryor, M
Domingo, JWS
Ryu, H
Camper, AK
Olson, A
Pruden, A
AF Wang, Hong
Proctor, Caitlin R.
Edwards, Marc A.
Pryor, Marsha
Domingo, Jorge W. Santo
Ryu, Hodon
Camper, Anne K.
Olson, Andrew
Pruden, Amy
TI Microbial Community Response to Chlorine Conversion in a Chloraminated
Drinking Water Distribution System
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID AMMONIA-OXIDIZING BACTERIA; CONTROLLING NITRIFICATION; BIOLOGICAL
NITRIFICATION; PYROSEQUENCING ANALYSIS; PSEUDOMONAS-AERUGINOSA;
NITRIFYING BACTERIA; POTABLE WATER; DIVERSITY; OXIDATION; ARCHAEA
AB Temporary conversion to chlorine (i.e., "chlorine burn") is a common approach to controlling nitrification in chloraminated drinking water distribution systems, yet its effectiveness and mode(s) of action are not fully understood. This study characterized occurrence of nitrifying populations before, during and after a chlorine burn at 46 sites in a chloraminated distribution system with varying pipe materials and levels of observed nitrification. Quantitative polymerase chain reaction analysis of gene markers present in nitrifying populations indicated higher frequency of detection of ammonia oxidizing bacteria (AOB) (72% of samples) relative to ammonia oxidizing archaea (AOA) (28% of samples). Nitrospira nitrite oxidizing bacteria (NOB) were detected at 45% of samples, while presence of Nitrobacter NOB could not be confirmed at any of the samples. During the chlorine burn, the numbers of AOA, AOB, and Nitrospira greatly reduced (i.e., 0.8-2.4 log). However, rapid and continued regrowth of AOB and Nitrospira were observed along with nitrite production in the bulk water within four months after the chlorine burn, and nitrification outbreaks appeared to worsen 612 months later, even after adopting a twice annual burn program. Although high throughput sequencing of 16S rRNA genes revealed a distinct community shift and higher diversity index during the chlorine burn, it steadily returned towards a condition more similar to pre-burn than burn stage. Significant factors associated with nitrifier and microbial community composition included water age and sampling location type, but not pipe material. Overall, these results indicate that there is limited long-term effect of chlorine burns on nitrifying populations and the broader microbial community.
C1 [Wang, Hong; Proctor, Caitlin R.; Edwards, Marc A.; Pruden, Amy] Virginia Tech, Via Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Pryor, Marsha] Pinellas Cty Util Lab, Largo, FL 33778 USA.
[Domingo, Jorge W. Santo; Ryu, Hodon] US EPA, Cincinnati, OH 45220 USA.
[Camper, Anne K.; Olson, Andrew] Montana State Univ, Ctr Biofilm Engn, Bozeman, MT 59717 USA.
RP Pruden, A (reprint author), Virginia Tech, Via Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
EM apruden@vt.edu
RI Edwards, Marc/J-3557-2012
FU Alfred P. Sloan Foundation Microbiology of the Built Environment
Program; U.S. National Science Foundation CBET [1033498]; Sussman
Foundation; Pinellas County; U.S. Environmental Protection Agency,
through its Office of Research and Development; RARE program
FX Funding was provided in part by the Alfred P. Sloan Foundation
Microbiology of the Built Environment Program, the U.S. National Science
Foundation CBET Award No. 1033498, and student fellowships supported by
the Sussman Foundation and Pinellas County. Additionally, the U.S.
Environmental Protection Agency, through its Office of Research and
Development and the RARE program, funded in part and collaborated in the
research described herein. We also thank Fred Small of Pinellas County
Florida for assisting with sampling and data logging and Michael Elk for
technical assistance.
NR 58
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U1 6
U2 80
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 16
PY 2014
VL 48
IS 18
BP 10624
EP 10633
DI 10.1021/es502646d
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP1BN
UT WOS:000341801500013
PM 25118569
ER
PT J
AU Daughton, CG
AF Daughton, Christian G.
TI Eco-directed sustainable prescribing: feasibility for reducing water
contamination by drugs
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Drugs; Active pharmaceutical ingredients; Pharmacokinetics; Prescribing;
Water pollution; Sustainable healthcare
ID PERSONAL CARE PRODUCTS; DISPOSITION CLASSIFICATION-SYSTEM;
SEWAGE-TREATMENT PLANTS; WASTE-WATER; UNITED-STATES; NATIONAL
RECONNAISSANCE; ACTIVATED-SLUDGE; HUMAN HEALTH; RIVER WATER;
PHARMACEUTICALS
AB Active pharmaceutical ingredients (APIs) from the purchase and use of medications are recognized as ubiquitous contaminants of the environment. Ecological impacts can range from subtle to overt resulting from multi-generational chronic exposure to trace levels of multiple APIs (such as in the aquatic environment) or acute exposure to higher levels (such as with wildlife ingestion of improperly discarded waste). Reducing API entry to the environment has relied solely on conventional end-of-pipe pollution control measures such as wastewater treatment and take-back collections of leftover, unwanted drugs (to prevent disposal by flushing to sewers). An exclusive focus on these conventional approaches has ignored the root sources of the problem and may have served to retard progress in minimizing the environmental footprint of the healthcare industry. Potentially more effective and less-costly upstream pollution prevention approaches have long been considered imprudent, as they usually involve the modification of long-established norms in the practice of clinical prescribing. The first pollution prevention measure to be proposed as feasible (reducing the dose or usage of certain select medications) is followed here by an examination of another possible approach one that would rely on the excretion profiles of APIs. These two approaches combined could be termed eco-directed sustainable prescribing (EDSP) and may hold the potential for achieving the largest reductions in API entry to the environment largely by guiding prescribers' decisions regarding drug selection. EDSP could reduce API entry to the environment by minimizing the need for disposal (as a consequence of avoiding leftover, unwanted medications) and reducing the excretion of unmetabolized APIs (by preferentially prescribing APIs that are more extensively metabolized). The potential utility of the Biopharmaceutics Drug Disposition Classification System (BDDCS) is examined for the first time as a guide for API prescribing decisions by revealing relative API quantities entering sewage via excretion. Published by Elsevier B.V.
C1 US EPA, Div Environm Sci, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
RP Daughton, CG (reprint author), US EPA, Div Environm Sci, Natl Exposure Res Lab, 944 East Harmon Ave, Las Vegas, NV 89119 USA.
EM daughton.christian@epa.gov
OI Daughton, Christian/0000-0002-0302-7730
FU EPA-ORD's Pathfinder Innovation Program
FX U.S. EPA Notice: The views expressed in this article are those of the
author and do not necessarily reflect the views or policies of the U.S.
Environmental Protection Agency. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use. This
work was supported by EPA-ORD's Pathfinder Innovation Program, which was
launched in October, 2010. Greatly appreciated were the assistance of
MST Scuderi (SEEP, U.S. EPA, Las Vegas) in the maintenance of the
EndNote bibliographic database and the technical review of this
manuscript by Dr. Tamara Sorell (National Risk Practice Lead, Brown and
Caldwell, Andover, MA).
NR 77
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Z9 16
U1 11
U2 63
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD SEP 15
PY 2014
VL 493
BP 392
EP 404
DI 10.1016/j.scitotenv.2014.06.013
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AN0ZH
UT WOS:000340312000042
PM 24956075
ER
PT J
AU Wang, QS
Chu, CH
Qian, L
Chen, SH
Wilson, B
Oyarzabal, E
Jiang, LL
Ali, S
Robinson, B
Kim, HC
Hong, JS
AF Wang, Qingshan
Chu, Chun-Hsien
Qian, Li
Chen, Shih-Heng
Wilson, Belinda
Oyarzabal, Esteban
Jiang, Lulu
Ali, Syed
Robinson, Bonnie
Kim, Hyoung-Chun
Hong, Jau-Shyong
TI Substance P Exacerbates Dopaminergic Neurodegeneration through
Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE GPCR independence; NADPH oxidase; neuroinflammation; Parkinson's
disease; substance P
ID LIPOPOLYSACCHARIDE-INDUCED NEUROTOXICITY; CENTRAL-NERVOUS-SYSTEM;
PARKINSONS-DISEASE; OXIDATIVE STRESS; PROGRESSIVE NEURODEGENERATION;
CHRONIC NEUROINFLAMMATION; REACTIVE MICROGLIOSIS; BORRELIA-BURGDORFERI;
NOX ENZYMES; INHIBITION
AB Although dysregulated substance P (SP) has been implicated in the pathophysiology of Parkinson's disease (PD), how SP affects the survival of dopaminergic neurons remains unclear. Here, we found that mice lacking endogenous SP (TAC1(-/-)), but not those deficient in the SP receptor (neurokinin-1 receptor, NK1R), were more resistant to lipopolysaccharide (LPS)- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigral dopaminergic neurodegeneration than wild-type controls, suggesting a NK1R-independent toxic action of SP. In vitro dose-response studies revealed that exogenous SP enhanced LPS- and 1-methyl-4-phenylpyridinium (MPP+)-induced dopaminergic neurodegeneration in a bimodal manner, peaking at submicromolar and subpicomolar concentrations, but was substantially less effective at intermediate concentrations. Mechanistically, the actions of submicromolar levels of SP were NK1R-dependent, whereas subpicomolar SP-elicited actions required microglial NADPH oxidase (NOX2), the key superoxide-producing enzyme, but not NK1R. Subpicomolar concentrations of SP activated NOX2 by binding to the catalytic subunit gp91(phox) and inducing membrane translocation of the cytosolic subunits p47(phox) and p67(phox). The importance of NOX2 was further corroborated by showing that inhibition or disruption of NOX2 blocked subpicomolar SP-exacerbated neurotoxicity. Together, our findings revealed a critical role of microglial NOX2 in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD.
C1 [Wang, Qingshan; Chu, Chun-Hsien; Qian, Li; Chen, Shih-Heng; Wilson, Belinda; Oyarzabal, Esteban; Jiang, Lulu; Hong, Jau-Shyong] Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, Neuropharmacol Sect, Res Triangle Pk, NC 27709 USA.
[Ali, Syed; Robinson, Bonnie] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Neurochem Lab, Jefferson, AR 72079 USA.
[Kim, Hyoung-Chun] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea.
RP Wang, QS (reprint author), Natl Inst Environm Hlth Sci, 111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM wangq4@niehs.nih.gov; hong3@niehs.nih.gov
FU Intramural Research Program of the National Institutes of Health;
National Institute of Environmental Health Sciences
FX This work was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences. We thank Anthony Lockhart for assistance with animal
colony management and maintenance of the timed pregnant mice.
NR 49
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U1 0
U2 5
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD SEP 10
PY 2014
VL 34
IS 37
BP 12490
EP 12503
DI 10.1523/JNEUROSCI.2238-14.2014
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA AP0QH
UT WOS:000341766900022
PM 25209287
ER
PT J
AU Setzer, RW
AF Setzer, R. Woodrow
TI Evaluating MoE and its uncertainty and variability for food contaminants
SO TOXICOLOGY LETTERS
LA English
DT Meeting Abstract
CT 50th Congress of the European-Societies-of-Toxicology
CY SEP 07-10, 2014
CL Edinburgh, SCOTLAND
SP European Soc Toxicol, British Toxicol Soc, Soc Toxicol
C1 [Setzer, R. Woodrow] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD SEP 10
PY 2014
VL 229
SU S
MA PS3.4-O5
BP S28
EP S28
DI 10.1016/j.toxlet.2014.06.132
PG 1
WC Toxicology
SC Toxicology
GA AO2FY
UT WOS:000341134000087
ER
PT J
AU Thomas, R
AF Thomas, Russell
TI Integration of high-throughput in vitro assays and human exposure
modeling for risk-based chemical safety decisions
SO TOXICOLOGY LETTERS
LA English
DT Meeting Abstract
CT 50th Congress of the European-Societies-of-Toxicology
CY SEP 07-10, 2014
CL Edinburgh, SCOTLAND
SP European Soc Toxicol, British Toxicol Soc, Soc Toxicol
C1 [Thomas, Russell] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD SEP 10
PY 2014
VL 229
SU S
MA PS2.1-O1
BP S4
EP S4
DI 10.1016/j.toxlet.2014.06.039
PG 1
WC Toxicology
SC Toxicology
GA AO2FY
UT WOS:000341134000009
ER
PT J
AU Wang, DJ
Su, CM
Liu, CX
Zhou, DM
AF Wang, Dengjun
Su, Chunming
Liu, Chongxuan
Zhou, Dongmei
TI Transport of fluorescently labeled hydroxyapatite nanoparticles in
saturated granular media at environmentally relevant concentrations of
surfactants
SO COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
LA English
DT Article
DE Hydroxyapatite nanoparticle; Surfactant; Transport; Ripening; Porous
media; Groundwater remediation
ID WALLED CARBON NANOTUBES; DEEP-BED FILTRATION; POROUS-MEDIA; HUMIC-ACID;
IONIC-STRENGTH; ADSORPTION; COLLOIDS; MONTMORILLONITE; STABILIZATION;
AGGREGATION
AB Little is known about the mobility of engineered nanoparticles (ENPs) in granular media at environmentally relevant concentrations of surfactants, which represents a critical knowledge gap in employing ENPs for in situ remediation of contaminated groundwater. In this study, transport and retention of alizarin red S (ARS)-labeled hydroxyapatite nanoparticle (nHAP) were investigated in water-saturated sand at environmentally relevant concentrations of surfactants: anionic sodium dodecyl benzene sulfonate (SDBS, 0-50 mg L-1) and cationic cetyltrimethylammonium bromide (CTAB, 0-5 mg L-1). Transport of ARS-nHAP increased with increasing SDBS concentration because of enhanced colloidal stability and reduced aggregate size arising from enhanced electrostatic, osmotic, and elastic-steric repulsions between ARS-nHAP and sand grains. In contrast, transport decreased significantly with increasing CTAB concentration due to reduced surface charge and enhanced aggregation of ARS-nHAP. Osmotic and elastic-steric repulsions played a minor role in enhancing ARS-nHAP colloidal stability in CTAB tests. Retention profiles of ARS-nHAP exhibited hyperexponential-shapes for all conditions tested and became more pronounced as CTAB concentration increased. The phenomenon was attributed to the aggregation and ripening of ARS-nHAP in the presence of surfactants, particularly CTAB. Overall, the present study suggests that surfactant type and concentration may be important considerations in employing nHAP for engineered in situ remediation of metal- and radionuclide-contaminated groundwater. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wang, Dengjun; Zhou, Dongmei] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China.
[Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, Ada, OK 74820 USA.
[Liu, Chongxuan] Pacific NW Natl Lab, Div Chem & Mat Sci, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA.
[Wang, Dengjun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
RP Zhou, DM (reprint author), Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China.
EM dmzhou@issas.ac.cn
RI Liu, Chongxuan/C-5580-2009
FU National Basic Research and Development Program [2013CB934303]; National
Natural Science Foundation of china [41125007]
FX We gratefully acknowledge Drs. Scott A. Bradford (U.S. Salinity
Laboratory), Ronald W. Harvey (USGS), Larry B. Barber (USGS), Bin Gao
(University of Florida), and Wei Zhang (Michigan State University) for
their critical reviews and helpful suggestions of this manuscript.
Funding was provided by the National Basic Research and Development
Program 2013CB934303 and National Natural Science Foundation (41125007)
of China. This paper does not necessarily reflect the views of the U.S.
Environmental Protection Agency, and no official endorsement should be
inferred.
NR 52
TC 6
Z9 6
U1 9
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-7757
EI 1873-4359
J9 COLLOID SURFACE A
JI Colloid Surf. A-Physicochem. Eng. Asp.
PD SEP 5
PY 2014
VL 457
BP 58
EP 66
DI 10.1016/j.colsurfa.2014.05.041
PG 9
WC Chemistry, Physical
SC Chemistry
GA AN1KG
UT WOS:000340340600008
ER
PT J
AU Kopits, E
Marten, A
Wolverton, A
AF Kopits, Elizabeth
Marten, Alex
Wolverton, Ann
TI Incorporating 'catastrophic' climate change into policy analysis
SO CLIMATE POLICY
LA English
DT Article
DE integrated assessment; welfare impacts; climate change; social costs
ID AMAZONIAN FOREST DIEBACK; THERMOHALINE CIRCULATION; 20-1ST CENTURY;
TIPPING POINTS; DAMAGE COSTS; IMPACTS; UNCERTAINTY; ECONOMICS;
IRREVERSIBILITIES; STABILITY
AB Although existing economic research is informative with regard to the importance of including potential 'catastrophic' climate change impacts in the analysis of GHG mitigation benefits, the generic and abstract form of the 'catastrophe' implemented has led to a lack of specific policy implications. This article provides an important starting point for a discussion of how to improve economic modelling of potential large-scale impacts of climate change. It considers how the term 'abrupt climate change' has been used in the scientific literature to describe changes in the climate system and carefully reviews the characteristics of the events that have been discussed in this context. The findings are compared to the way in which the economic literature has modelled potential economic and human welfare impacts of these 'catastrophic' events. In general, the economics literature is found to have modelled such impacts in a uniform way that fails to account for differences in relevant end points and timescales. The result is policy recommendations based on events that do not resemble those of concern. Better treatment of these events in integrated assessment modelling would help ensure that future research efforts can serve as meaningful policy input.
C1 [Kopits, Elizabeth; Marten, Alex; Wolverton, Ann] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Kopits, E (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave,NW MC 1809T, Washington, DC 20460 USA.
EM kopits.elizabeth@epa.gov
NR 67
TC 1
Z9 1
U1 4
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1469-3062
EI 1752-7457
J9 CLIM POLICY
JI Clim. Policy
PD SEP 3
PY 2014
VL 14
IS 5
BP 637
EP 664
DI 10.1080/14693062.2014.864947
PG 28
WC Environmental Studies; Public Administration
SC Environmental Sciences & Ecology; Public Administration
GA AS3FC
UT WOS:000344161100006
ER
PT J
AU Madden, MC
Stevens, T
Case, M
Schmitt, M
Diaz-Sanchez, D
Bassett, M
Montilla, TS
Berntsen, J
Devlin, RB
AF Madden, Michael C.
Stevens, Tina
Case, Martin
Schmitt, Michael
Diaz-Sanchez, David
Bassett, Maryann
Montilla, Tracey S.
Berntsen, Jon
Devlin, Robert B.
TI Diesel exhaust modulates ozone-induced lung function decrements in
healthy human volunteers
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
DE Diesel exhaust; Ozone; Co-exposure; Lung function; Greater than additive
effects
ID INFLAMMATORY RESPONSES; AIRWAY INFLAMMATION; PULMONARY-FUNCTION;
EPITHELIAL-CELLS; SULFURIC-ACID; IN-VITRO; EXPOSURE; PARTICULATE;
INHIBITION; ADAPTATION
AB The potential effects of combinations of dilute whole diesel exhaust (DE) and ozone (O-3), each a common component of ambient airborne pollutant mixtures, on lung function were examined. Healthy young human volunteers were exposed for 2 hr to pollutants while exercising (similar to 50 L/min) intermittently on two consecutive days. Day 1 exposures were either to filtered air, DE (300 mu g/m(3)), O-3 (0.300 ppm), or the combination of both pollutants. On Day 2 all exposures were to O-3 (0.300 ppm), and Day 3 served as a followup observation day. Lung function was assessed by spirometry just prior to, immediately after, and up to 4 hr post-exposure on each exposure day. Functional pulmonary responses to the pollutants were also characterized based on stratification by glutathione S-transferase mu 1 (GSTM1) genotype. On Day 1, exposure to air or DE did not change FEV1 or FVC in the subject population (n = 15). The co-exposure to O-3 and DE decreased FEV1 (17.6%) to a greater extent than O-3 alone (9.9%). To test for synergistic exposure effects, i.e., in a greater than additive fashion, FEV1 changes post individual O-3 and DE exposures were summed together and compared to the combined DE and O-3 exposure; the p value was 0.057. On Day 2, subjects who received DE exposure on Day 1 had a larger FEV1 decrement (14.7%) immediately after the O-3 exposure than the individuals' matched response following a Day 1 air exposure (10.9%). GSTM1 genotype did not affect the magnitude of lung function changes in a significant fashion. These data suggest that altered respiratory responses to the combination of O-3 and DE exposure can be observed showing a greater than additive manner. In addition, O-3-induced lung function decrements are greater with a prior exposure to DE compared to a prior exposure to filtered air. Based on the joint occurrence of these pollutants in the ambient environment, the potential exists for interactions in more than an additive fashion affecting lung physiological processes.
C1 [Madden, Michael C.; Stevens, Tina; Case, Martin; Schmitt, Michael; Diaz-Sanchez, David; Bassett, Maryann; Montilla, Tracey S.; Devlin, Robert B.] US EPA, NHEERL, EPHD, Res Triangle Pk, NC 27711 USA.
[Berntsen, Jon] TRC Environm, Chapel Hill, NC 27514 USA.
[Madden, Michael C.] US EPA, Human Studies Facil, Chapel Hill, NC 27599 USA.
RP Madden, MC (reprint author), US EPA, NHEERL, EPHD, Res Triangle Pk, NC 27711 USA.
EM madden.michael@epa.gov
NR 40
TC 9
Z9 9
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD SEP 2
PY 2014
VL 11
AR 37
DI 10.1186/s12989-014-0037
PG 10
WC Toxicology
SC Toxicology
GA AY7IA
UT WOS:000347733000001
PM 25178924
ER
PT J
AU Rice, KC
Scanlon, TM
Lynch, JA
Cosby, BJ
AF Rice, Karen C.
Scanlon, Todd M.
Lynch, Jason A.
Cosby, Bernard J.
TI Decreased Atmospheric Sulfur Deposition across the Southeastern US: When
Will Watersheds Release Stored Sulfate?
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NORTHEASTERN UNITED-STATES; ACIDIC DEPOSITION; WESTERN VIRGINIA;
ADSORPTION; STREAMS; ACIDIFICATION; CHEMISTRY; ECOSYSTEM; INPUTS; SITES
AB Emissions of sulfur dioxide (SO2) to the atmosphere lead to atmospheric deposition of sulfate (SO42-), which is the dominant strong acid anion causing acidification of surface waters and soils in the eastern United States. Since passage of the Clean Air Act and its Amendments, atmospheric deposition of SO2 in this region has declined by over 80%, but few corresponding decreases in streamwater SO42- concentrations have been observed in unglaciated watersheds. We calculated SO42- mass balances for 27 forested, unglaciated watersheds from Pennsylvania to Georgia, by using total atmospheric deposition (wet plus dry) as input. Many of these watersheds still retain SO42-, unlike their counterparts in the northeastern U.S. and southern Canada. Our analysis showed that many of these watersheds should convert from retaining to releasing SO42- over the next two decades. The specific years when the watersheds crossover from retaining to releasing SO42- correspond to a general geographical pattern of later net watershed release from north to south. The single most important variable that explained the crossover year was the runoff ratio, defined as the ratio of annual mean stream discharge to precipitation. Percent clay content and mean soil depth were secondary factors in predicting crossover year. The conversion of watersheds from net SO42- retention to release anticipates more widespread reductions in streamwater SO42- concentrations in this region.
C1 [Rice, Karen C.] Univ Virginia, US Geol Survey, Charlottesville, VA 22904 USA.
[Rice, Karen C.; Scanlon, Todd M.; Cosby, Bernard J.] Univ Virginia, Dept Environm Sci, Charlottesville, VA 22904 USA.
[Lynch, Jason A.] US EPA, Washington, DC 20460 USA.
[Cosby, Bernard J.] Ctr Ecol & Hydrol, Bangor LL57, Gwynedd, Wales.
RP Rice, KC (reprint author), Univ Virginia, US Geol Survey, POB 400123, Charlottesville, VA 22904 USA.
EM kcrice@usgs.gov
RI Rice, Karen/A-8945-2013; Cosby, Bernard/B-5653-2012;
OI Rice, Karen/0000-0002-9356-5443
FU National Park Service (NPS); National Science Foundation (NSF); U.S.
Department of Agriculture Forest Service (USFS); U.S. Environmental
Protection Agency (EPA); U.S. Geological Survey (USGS); NSF
[DEB-0823293]
FX We thank James Shanley (USGS) and the three journal reviewers for
helpful comments, which significantly improved the manuscript. We
recognize the federal agencies that funded collection of data used in
the analysis: National Park Service (NPS); National Science Foundation
(NSF); U.S. Department of Agriculture Forest Service (USFS); U.S.
Environmental Protection Agency (EPA); and U.S. Geological Survey
(USGS); and the site contacts who graciously shared data: Brent
Aulenbach (USGS); James Lynch (PSU); Chelcy Miniat (USFS); Dean Tucker
(NPS); Rick Webb (UVa.); and Frederica Wood (USFS). This paper has not
been subjected to EPA peer and administrative review; therefore, the
conclusions and opinions contained herein are solely those of the
authors, and should not be construed to reflect the views of the EPA.
Data provided by the Coweeta Long Term Ecological Research Program
(LTER) were collected in the course of research supported by NSF award
DEB-0823293 from the LTER to the Coweeta LTER at the University of
Georgia. Any opinions, findings, conclusions, or recommendations
expressed in the material are those of the authors and do not
necessarily reflect the views of the NSF or the University of Georgia.
Any use of trade, firm, or product names is for descriptive purposes
only and does not imply endorsement by the U.S. Government.
NR 30
TC 10
Z9 10
U1 2
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 2
PY 2014
VL 48
IS 17
BP 10071
EP 10078
DI 10.1021/es501579s
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AO3KY
UT WOS:000341229300018
PM 25046800
ER
PT J
AU Thomas, JM
Thomas, T
Stuetz, RM
Ashbolt, NJ
AF Thomas, Jacqueline M.
Thomas, Torsten
Stuetz, Richard M.
Ashbolt, Nicholas J.
TI Your Garden Hose: A Potential Health Risk Due to Legionella spp. Growth
Facilitated by Free-Living Amoebae
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DRINKING-WATER SUPPLIES; REAL-TIME PCR; LEGIONNAIRES-DISEASE;
NONTUBERCULOUS MYCOBACTERIA; ACANTHAMOEBA-CASTELLANII;
PSEUDOMONAS-AERUGINOSA; RESISTING BACTERIA; HARTMANNELLA-VERMIFORMIS;
ETHIDIUM MONOAZIDE; TREATMENT-PLANT
AB Common garden hoses may generate aerosols of inhalable size (<= 10 mu m) during use. If humans inhale aerosols containing Legionella bacteria, Legionnaires' disease or Pontiac fever may result. Clinical cases of these illnesses have been linked to garden hose use. The hose environment is ideal for the growth and interaction of Legionella and free-living amoebae (FLA) due to biofilm formation, elevated temperatures, and stagnation of water. However, the microbial densities and hose conditions necessary to quantify the human health risks have not been reported. Here we present data on FLA and Legionella spp. detected in water and biofilm from two types of garden hoses over 18 months. By culturing and qPCR, two genera of FLA were introduced via the drinking water supply and reached mean densities of 2.5 log(10) amoebae.mL(-1) in garden hose water. Legionella spp. densities (likely including pathogenic L. pneumophila) were significantly higher in one type of hose (3.8 log(10) cells.mL(-1), p < 0.0001). A positive correlation existed between Vermamoebae vermiformis densities and Legionella spp. densities (r = 0.83, p < 0.028). The densities of Legionella spp. identified in the hoses were similar to those reported during legionellosis outbreaks in other situations. Therefore, we conclude that there is a health risk to susceptible users from the inhalation of garden hose aerosols.
C1 [Thomas, Jacqueline M.; Stuetz, Richard M.; Ashbolt, Nicholas J.] Univ New S Wales, Sch Civil & Environm Engn, Sydney, NSW 2052, Australia.
[Thomas, Torsten] Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia.
[Thomas, Torsten] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia.
[Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Thomas, JM (reprint author), Ifakara Hlth Inst, Environm Hlth & Ecol Sci Grp, Morogoro, Tanzania.
EM drjacquiethomas@gmail.com
FU American Australian Association
FX We acknowledge the American Australian Association for their support via
a Research Fellowship to the primary author. We also acknowledge Brett
Robinson for supplying some of the FLA control cultures and providing
training (Australian Water Quality Centre, Adelaide).
NR 81
TC 5
Z9 5
U1 3
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 2
PY 2014
VL 48
IS 17
BP 10456
EP 10464
DI 10.1021/es502652n
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AO3KY
UT WOS:000341229300063
PM 25075763
ER
PT J
AU Wilson, A
Rappold, AG
Neas, LM
Reich, BJ
AF Wilson, Ander
Rappold, Ana G.
Neas, Lucas M.
Reich, Brian J.
TI MODELING THE EFFECT OF TEMPERATURE ON OZONE-RELATED MORTALITY
SO ANNALS OF APPLIED STATISTICS
LA English
DT Article
DE Air pollution; monotone regression; mortality; ozone-temperature
interaction; semi-parametric regression; spatial modeling
ID DISTRIBUTED LAG MODELS; US URBAN COMMUNITIES; SHORT-TERM MORTALITY;
AIR-POLLUTION; RESPONSE RELATIONSHIPS; BERNSTEIN POLYNOMIALS; NMMAPS
DATA; EXPOSURE; SENSITIVITY; POLLUTANTS
AB Climate change is expected to alter the distribution of ambient ozone levels and temperatures which, in turn, may impact public health. Much research has focused on the effect of short-term ozone exposures on mortality and morbidity while controlling for temperature as a confounder, but less is known about the joint effects of ozone and temperature. The extent of the health effects of changing ozone levels and temperatures will depend on whether these effects are additive or synergistic. In this paper we propose a spatial, semi-parametric model to estimate the joint ozone-temperature risk surfaces in 95 US urban areas. Our methodology restricts the ozone-temperature risk surfaces to be monotone in ozone and allows for both nonadditive and nonlinear effects of ozone and temperature. We use data from the National Mortality and Morbidity Air Pollution Study (NMMAPS) and show that the proposed model fits the data better than additive linear and nonlinear models. We then examine the synergistic effect of ozone and temperature both nationally and locally and find evidence of a nonlinear ozone effect and an ozone-temperature interaction at higher temperatures and ozone concentrations.
C1 [Wilson, Ander; Reich, Brian J.] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
[Rappold, Ana G.; Neas, Lucas M.] US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
RP Wilson, A (reprint author), N Carolina State Univ, Dept Stat, 2311 Stinson Dr, Raleigh, NC 27695 USA.
EM ander_wilson@ncsu.edu; rappold.ana@epa.gov; neas.lucas@epa.gov;
brian_reich@ncsu.edu
FU EPA [R835228]; NIH [5R01ES014843-02]
FX Supported in part by the EPA (R835228) and NIH (5R01ES014843-02).
NR 45
TC 8
Z9 8
U1 3
U2 6
PU INST MATHEMATICAL STATISTICS
PI CLEVELAND
PA 3163 SOMERSET DR, CLEVELAND, OH 44122 USA
SN 1932-6157
J9 ANN APPL STAT
JI Ann. Appl. Stat.
PD SEP
PY 2014
VL 8
IS 3
BP 1728
EP 1749
DI 10.1214/14-AOAS754
PG 22
WC Statistics & Probability
SC Mathematics
GA AY4DW
UT WOS:000347529300019
ER
PT J
AU McCullough, SD
Duncan, KE
Swanton, SM
Dailey, LA
Diaz-Sanchez, D
Devlin, RB
AF McCullough, Shaun D.
Duncan, Kelly E.
Swanton, Samantha M.
Dailey, Lisa A.
Diaz-Sanchez, David
Devlin, Robert B.
TI Ozone Induces a Proinflammatory Response in Primary Human Bronchial
Epithelial Cells through Mitogen-Activated Protein Kinase Activation
Without Nuclear Factor-kappa B Activation
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE ozone; inflammation; kinase; airway; pollution
ID EPIDERMAL-GROWTH-FACTOR; OXIDATIVE STRESS; AIRWAY EPITHELIUM; TYROSINE
KINASE; IL-8 EXPRESSION; FACTOR RECEPTOR; MORTALITY; EXPOSURE; PATHWAY;
CANCER
AB Ground-level ozone (O-3) is a ubiquitous environmental air pollutant that is a potent inducer of airway inflammation and has been linked with respiratory and cardiovascular morbidity and mortality. Some studies using transformed or immortalized cells have attributed O-3-mediated expression of inflammatory cytokines with activation of the canonical NF-kappa B pathway. In this study, we sought to characterize the O-3-mediated activation of cellular signaling pathways using primary human bronchial epithelial cells obtained from a panel of donors. We demonstrate that the O-3-induced expression of proinflammatory cytokines requires the activation of the epidermal growth factor receptor/MEK/ERK and MKK4/p38 mitogen-activated signaling pathways but does not appear to involve activation of canonical NF-kappa B signaling. In addition to providing a novel mechanistic model for the O-3-mediated induction of proinflammatory cytokines, these findings highlight the importance of using primary cells over cell lines in mechanistic studies.
C1 [McCullough, Shaun D.; Swanton, Samantha M.; Dailey, Lisa A.; Diaz-Sanchez, David; Devlin, Robert B.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27711 USA.
[Duncan, Kelly E.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Duncan, Kelly E.] Fox Chase Canc Ctr, Canc Biol Program, Philadelphia, PA 19111 USA.
RP McCullough, SD (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, 104 Mason Farm Rd, Chapel Hill, NC 27711 USA.
EM mccullough.shaun@epa.gov
NR 42
TC 12
Z9 12
U1 0
U2 5
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD SEP
PY 2014
VL 51
IS 3
BP 426
EP 435
DI 10.1165/rcmb.2013-0515OC
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KC
UT WOS:000347417800011
PM 24693990
ER
PT J
AU Wobus, C
Lawson, M
Jones, R
Smith, J
Martinich, J
AF Wobus, C.
Lawson, M.
Jones, R.
Smith, J.
Martinich, J.
TI Estimating monetary damages from flooding in the United States under a
changing climate
SO JOURNAL OF FLOOD RISK MANAGEMENT
LA English
DT Article
DE Climate change; modelling; precipitation
ID INTENSE PRECIPITATION; RISK; TRENDS; EXTREMES; LOSSES; ENGLAND; WEATHER;
EVENTS; RECORD; WALES
AB Extreme precipitation events are likely to become more frequent and more extreme under a changing climate. It follows that monetary damages from flooding would also increase relative to baseline, yet this relationship has not been quantified at the scale of the entire United States. In this paper, we quantify how climate change could affect monetary damages from flooding in the coterminous United States. With publicly available historical flooding and precipitation data, we estimate region-specific logistic regression models of the probability that severely damaging floods will occur under baseline conditions. We then use future precipitation projections driven by climate model outputs to estimate the probability that damaging floods could occur under a 'business as usual' climate change scenario. Our results project an increase in monetary damages from flooding in nearly all regions of the United States and a total increase in damages by the end of century of approximately 30% (assuming no change in built infrastructure or values). However, these changes vary between regions due to differences in the mechanisms driving flooding and general circulation model precipitation projections.
C1 [Wobus, C.; Lawson, M.; Jones, R.; Smith, J.] Stratus Consulting Inc, Boulder, CO USA.
[Martinich, J.] US EPA, Washington, DC 20460 USA.
RP Wobus, C (reprint author), 1881 Ninth St,Suite 201, Boulder, CO 80303 USA.
EM cwobus@stratusconsulting.com
NR 27
TC 7
Z9 7
U1 2
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-318X
J9 J FLOOD RISK MANAG
JI J. Flood Risk Manag.
PD SEP
PY 2014
VL 7
IS 3
BP 217
EP 229
DI 10.1111/jfr3.12043
PG 13
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA AU2AG
UT WOS:000345417900004
ER
PT J
AU Wang, JD
Wang, SX
Jiang, JK
Ding, AJ
Zheng, M
Zhao, B
Wong, DC
Zhou, W
Zheng, GJ
Wang, L
Pleim, JE
Hao, JM
AF Wang, Jiandong
Wang, Shuxiao
Jiang, Jingkun
Ding, Aijun
Zheng, Mei
Zhao, Bin
Wong, David C.
Zhou, Wei
Zheng, Guangjie
Wang, Long
Pleim, Jonathan E.
Hao, Jiming
TI Impact of aerosol-meteorology interactions on fine particle pollution
during China's severe haze episode in January 2013
SO ENVIRONMENTAL RESEARCH LETTERS
LA English
DT Article
DE meteorology; fine particles; aerosol-radiation interactions; haze; solar
radiation
ID PLANETARY BOUNDARY-LAYER; NONLOCAL CLOSURE-MODEL; LAND-SURFACE MODEL;
PHASE SIMULATIONS; CHEMISTRY MODELS; EASTERN CHINA; WEATHER; SYSTEM;
EVOLUTION; AMAZON
AB In January 2013, a severe regional haze occurred over the North China Plain. An online-coupled meteorology-chemistry model was employed to simulate the impacts of aerosol-meteorology interactions on fine particles (PM2.5) pollution during this haze episode. The response of PM2.5 to meteorology change constituted a feedback loop whereby planetary boundary layer (PBL) dynamics amplified the initial perturbation of PM2.5. High PM2.5 concentrations caused a decrease of surface solar radiation. The maximal decrease in daily average solar radiation reached 53% in Beijing, thereby leading to a more stable PBL. The peak PBL height in Beijing decreased from 690 m to 590 m when the aerosol extinction was considered. Enhanced PBL stability suppressed the dispersion of air pollutants, and resulted in higher PM2.5 concentrations. The maximal increase of PM2.5 concentrations reached 140 mu g m(-3) in Beijing. During most PM2.5 episodes, primary and secondary particles increased simultaneously. These results imply that the aerosol-radiation interactions played an important role in the haze episode in January 2013.
C1 [Wang, Jiandong; Wang, Shuxiao; Jiang, Jingkun; Zhao, Bin; Zhou, Wei; Zheng, Guangjie; Wang, Long; Hao, Jiming] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Wang, Jiandong; Wang, Shuxiao; Jiang, Jingkun; Zhao, Bin; Zhou, Wei; Zheng, Guangjie; Wang, Long; Hao, Jiming] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Ding, Aijun] Nanjing Univ, Inst Climate & Global Change Res, Nanjing 210008, Jiangsu, Peoples R China.
[Ding, Aijun] Nanjing Univ, Sch Atmospher Sci, Nanjing 210008, Jiangsu, Peoples R China.
[Zheng, Mei] Peking Univ, Sch Environm Sci & Engn, Beijing 100084, Peoples R China.
[Wong, David C.; Pleim, Jonathan E.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Wang, JD (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI Zheng, Guangjie/A-9927-2015; Jiang, Jingkun/A-1076-2010; wang,
shuxiao/H-5990-2011; Ding, Aijun/D-1610-2009; Pleim, Jonathan
Pleim/C-1331-2017
OI Zheng, Guangjie/0000-0002-8103-2594; wang, shuxiao/0000-0001-9727-1963;
Ding, Aijun/0000-0003-4481-5386; Pleim, Jonathan
Pleim/0000-0001-6190-6082
FU National Natural Science Foundation of China [21221004]; MEP's Special
Funds for Research on Public Welfares [201309009, 201409002]; Strategic
Priority Research Program of the Chinese Academy of Sciences
[XBD05020300]; special fund of State Key Joint Laboratory of Environment
Simulation and Pollution Control [12L05ESPC]; Collaborative Innovation
Center for Regional Environmental Quality
FX This work was sponsored by National Natural Science Foundation of China
(21221004), MEP's Special Funds for Research on Public Welfares
(201309009 and 201409002), Strategic Priority Research Program of the
Chinese Academy of Sciences (XBD05020300) and special fund of State Key
Joint Laboratory of Environment Simulation and Pollution Control
(12L05ESPC). The authors also appreciate the support from the
Collaborative Innovation Center for Regional Environmental Quality and
support from Prof Michael B McElroy and Mr Chris Nielsen of China
Project, School of Engineering and Applied Science, Harvard University.
We thank Weidong Guo, Scott Voorhees, and Xueying Zhang for their
helpful discussion.
NR 42
TC 11
Z9 15
U1 11
U2 99
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-9326
J9 ENVIRON RES LETT
JI Environ. Res. Lett.
PD SEP
PY 2014
VL 9
IS 9
AR 094002
DI 10.1088/1748-9326/9/9/094002
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AT5DK
UT WOS:000344963500007
ER
PT J
AU Bencko, V
Chen, C
AF Bencko, Vladimir
Chen, Chao
TI EPIDEMIOLOGICAL DATA AND CANCER RISK ASSESSMENT: CESSATION LAG AND
LINGERING EFFECT CONCEPTS
SO CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE epidemiological data; carcinogenicity; multicentre studies; lingering
effect; cessation lag; risk assessment
ID MENDELIAN RANDOMIZATION APPROACH; LUNG-CANCER; OCCUPATIONAL-EXPOSURE;
POLYMORPHISMS; EUROPE; METAANALYSES; EXPERIENCE; HEALTH; URINE; GENES
AB Cessation lag and lingering effect are two important aspects of risk assessment, and have potential applications to dose-response analysis in risk assessment. In addition to providing insight into biological mode of action, the concept of cessation lag is useful for economic benefit analysis. Concept of effect lingering can be used to analyze epidemiological data by uncovering the hidden biological implications related to disease endpoints, thereby advancing current efforts to characterize and reduce risk assessment uncertainties.
Multicentre study design is proposed as a way to increase study size and to mitigate criticism of meta-analysis of independent studies. Individual studies from a multicentre study can be either pooled using original data, or combined by meta-analysis of summarized results. A multicentre study of large cohort or case-control study also offers an exciting opportunity to study the contribution of epigenetic events that may be associated with life-style and environmental risk factors for human health. Methods for optimizing exposure assessment and reducing exposure misclassification represent important but difficult components in epidemiological studies. Biomarkers present a potentially useful approach for improving exposure estimates.
C1 [Bencko, Vladimir] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague 2, Czech Republic.
[Chen, Chao] US EPA, Washington, DC 20460 USA.
RP Bencko, V (reprint author), Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Studnickova 7, Prague 2, Czech Republic.
EM vladimir.bencko@lf1.cuni.cz
FU League Against Cancer, Prague; [PRVOUK-P28/1FF/6]
FX The paper was written within activities supported by the project
PRVOUK-P28/1FF/6 and the League Against Cancer, Prague.
NR 33
TC 0
Z9 0
U1 1
U2 5
PU NATL INST PUBLIC HEALTH
PI PRAGUE 10
PA DEPT SCIENTIFIC INFORMATION, SROBAROVA 48, PRAGUE 10, 100 42, CZECH
REPUBLIC
SN 1210-7778
EI 1803-1048
J9 CENT EUR J PUBL HEAL
JI Cent. Eur. J. Public Health
PD SEP
PY 2014
VL 22
IS 3
BP 197
EP 200
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AS0KY
UT WOS:000343967200012
PM 25438399
ER
PT J
AU Oshiro, WM
Beasley, TE
McDaniel, KL
Taylor, MM
Evansky, P
Moser, VC
Gilbert, ME
Bushnell, PJ
AF Oshiro, W. M.
Beasley, T. E.
McDaniel, K. L.
Taylor, M. M.
Evansky, P.
Moser, V. C.
Gilbert, M. E.
Bushnell, P. J.
TI Selective cognitive deficits in adult rats after prenatal exposure to
inhaled ethanol
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Developmental; Ethanol; Inhalation; Prenatal exposure; Cognitive
function; Biofuels
ID ALCOHOL SPECTRUM DISORDERS; DELAY-DEPENDENT IMPAIRMENT;
CENTRAL-NERVOUS-SYSTEM; CHOICE-REACTION-TIME; MORRIS WATER MAZE;
ANIMAL-MODELS; SPATIAL NAVIGATION; DEVELOPMENTAL EXPOSURE; SUSTAINED
ATTENTION; PASSIVE-AVOIDANCE
AB Increased use of ethanol blends in gasoline suggests a need to assess the potential public health risks of exposure to these fuels. Ethanol consumed during pregnancy is a teratogen. However, little is known about the potential developmental neurotoxicity of ethanol delivered by inhalation, the most likely route of exposure from gasoline-ethanol fuel blends. We evaluated the potential cognitive consequences of ethanol inhalation by exposing pregnant Long Evans rats to clean air or ethanol vapor from gestational days 9-20, a critical period of neuronal development. Concentrations of inhaled ethanol (5000, 10,000, or 21,000 ppm for 6.5 h/day) produced modeled peak blood ethanol concentrations (BECs) in exposed dams of 2.3, 6.8, and 192 mg/dL, respectively. In offspring, no dose-related impairments were observed on spatial learning or working memory in the Morris water maze or in operant delayed match-to-position tests. Two measures showed significant effects in female offspring at all ethanol doses: 1) impaired cue learning after trace fear conditioning, and 2) an absence of bias for the correct quadrant after place training during a reference memory probe in the Morris water maze. In choice reaction time tests, male offspring (females were not tested) from the 5000 and 10,000 ppm groups showed a transient increase in decision times. Also, male offspring from the 21,000 ppm group made more anticipatory responses during a preparatory hold period, suggesting a deficit in response inhibition. The increase in anticipatory responding during the choice reaction time test shows that inhaled ethanol yielding a peak BEC of similar to 200 mg/dL can produce lasting effects in the offspring. The lack of a dose-related decrement in the effects observed in females on cue learning and a reference memory probe may reflect confounding influences in the exposed offspring possibly related to maternal care or altered anxiety levels in females. The surprising lack of more pervasive cognitive deficits, as reported by others at BECs in the 200 mg/dL range, may reflect route-dependent differences in the kinetics of ethanol. These data show that response inhibition was impaired in the offspring of pregnant rats that inhaled ethanol at concentrations at least 5 orders of magnitude higher than concentrations observed during normal automotive transport and fueling operations, which rarely exceed 100 ppb. Published by Elsevier Inc.
C1 [Oshiro, W. M.; Beasley, T. E.; McDaniel, K. L.; Taylor, M. M.; Moser, V. C.; Gilbert, M. E.; Bushnell, P. J.] US EPA, Tox Assessment Div, Natl Hlth Effects & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Evansky, P.] US EPA, Environm Publ Hlth Div, Natl Hlth Effects & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Oshiro, WM (reprint author), US EPA, NHEERL TAD NB, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM oshiro.wendy@epa.gov; beasley.tracey@epa.gov; mcdaniel.kathy@epa.gov;
taylor.michelemmt@gmail.com; evansky.paul@epa.gov; moser.ginger@epa.gov;
gilbertmary@epa.gov; bushnell.philip@epa.gov
NR 98
TC 7
Z9 7
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD SEP-OCT
PY 2014
VL 45
BP 44
EP 58
DI 10.1016/j.ntt.2014.07.001
PG 15
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA AS7HP
UT WOS:000344427900005
PM 25020118
ER
PT J
AU Beasley, TE
Evansky, PA
Martin, SA
McDaniel, KL
Moser, VC
Luebke, RW
Norwood, J
Rogers, JM
Copeland, CB
Bushnell, PJ
AF Beasley, Tracey E.
Evansky, Paul A.
Martin, Sheppard A.
McDaniel, Katherine L.
Moser, Virginia C.
Luebke, Robert W.
Norwood, Joel, Jr.
Rogers, John M.
Copeland, Carey B.
Bushnell, Philip J.
TI Toxicological outcomes in rats exposed to inhaled ethanol during
gestation
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Ethanol; Development; Inhalation; Neurotoxicity; Biofuels
ID PRENATAL ALCOHOL EXPOSURE; CENTRAL-NERVOUS-SYSTEM; GATED ION CHANNELS;
IN-UTERO; CONSUMPTION; ADULT; ACETALDEHYDE; INHALATION; BEHAVIOR;
PERFORMANCE
AB Recent legislation has encouraged replacing petroleum-based fuels with renewable alternatives including ethanol, which is typically blended with gasoline in the United States at concentrations up to 10%, with allowances for concentrations up to 85% for some vehicles. Efforts to increase the amount of ethanol in gasoline have prompted concerns about the potential toxicity of inhaled ethanol vapors from these fuels. The well-known sensitivity of the developing nervous and immune systems to ingested ethanol, and the lack of information about its toxicity by inhalation prompted the present work on its potential developmental effects in a rat model. Pregnant Long Evans rats were exposed for 6.5 h/day on days 9-20 of gestation to clean air or ethanol vapor at concentrations of 5000, 10,000, or 21,000 ppm, which resulted in estimated peak blood ethanol concentrations (BECs) of 2.3, 6.7, and 192 mg/dL, respectively. No overt toxicity in the dams was observed. Ethanol did not affect litter size or weight, or postnatal weight gain in the pups. Motor activity was normal in offspring through postnatal day (PND) 29. On PND 62, the 5000 and 21,000 ppm groups were more active than controls. On PND 29 and 62, offspring were tested with a functional observational battery, which revealed small changes in the neuromuscular and sensorimotor domains that were not systematically related to dose. Cell-mediated and humoral immunity were not affected by ethanol exposure in 6-week-old offspring. Systolic blood pressure was increased by 10,000 ppm ethanol in males at PND 90 but not at PND 180. No differences in lipoprotein profile, liver function, or kidney function were observed. In summary, prenatal exposure to inhaled ethanol caused some mild changes in physiological and behavioral development in offspring that were not clearly related to inhaled concentration or BEC, and did not produce detectable changes in immune function. This low toxicity of inhaled ethanol may result from the slow rise in BEC by the inhalation route. Published by Elsevier Inc.
C1 [Beasley, Tracey E.; Martin, Sheppard A.; McDaniel, Katherine L.; Moser, Virginia C.; Norwood, Joel, Jr.; Rogers, John M.; Bushnell, Philip J.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Evansky, Paul A.; Luebke, Robert W.; Copeland, Carey B.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Beasley, TE (reprint author), US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM beasley.tracey@epa.gov
NR 68
TC 3
Z9 3
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD SEP-OCT
PY 2014
VL 45
BP 59
EP 69
DI 10.1016/j.ntt.2014.07.002
PG 11
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA AS7HP
UT WOS:000344427900006
PM 25092052
ER
PT J
AU Cole, AS
Steffen, A
Eckley, CS
Narayan, J
Pilote, M
Tordon, R
Graydon, JA
St Louis, VL
Xu, XH
Branfireun, BA
AF Cole, Amanda S.
Steffen, Alexandra
Eckley, Chris S.
Narayan, Julie
Pilote, Martin
Tordon, Rob
Graydon, Jennifer A.
St Louis, Vincent L.
Xu, Xiaohong
Branfireun, Brian A.
TI A Survey of Mercury in Air and Precipitation across Canada: Patterns and
Trends
SO ATMOSPHERE
LA English
DT Article
DE elemental mercury; total gaseous mercury; reactive mercury; gaseous
oxidized mercury; particulate mercury; cycling of atmospheric mercury;
mercury in precipitation; mercury trends
ID TOTAL GASEOUS MERCURY; MEASUREMENT NETWORK CAMNET; ATMOSPHERIC MERCURY;
WET DEPOSITION; REDOX TRANSFORMATIONS; UNITED-STATES; SITES; EMISSIONS;
SOILS; SPECIATION
AB Atmospheric mercury (Hg) measurements from across Canada were compiled and analysed as part of a national Hg science assessment. Here we update long-term trends of Hg in air and precipitation, and present more extensive measurements on patterns and trends in speciated Hg species (gaseous elemental mercury-GEM, reactive gaseous mercury-RGM, and total particulate mercury on particles < 2.5 mu m-TPM2.5) at several sites. A spatial analysis across Canada revealed higher air concentrations and wet deposition of Hg in the vicinity of local and regional emission sources, and lower air concentrations of Hg at mid-latitude maritime sites compared to continental sites. Diel and seasonal patterns in atmospheric GEM, RGM and TPM2.5 concentrations reflected differences in patterns of anthropogenic emissions, photo-induced surface emissions, chemistry, deposition and mixing. Concentrations of GEM decreased at rates ranging from -0.9% to -3.3% per year at all sites where measurements began in the 1990s. Concentrations of total Hg in precipitation declined up to 3.7% yr(-1). Trends in RGM and TPM2.5 were less clear due to shorter measurement periods and low concentrations, however, in spring at the high Arctic site (Alert) when RGM and TPM2.5 concentrations were high, concentrations of both increased by 7%-10% per year.
C1 [Cole, Amanda S.; Steffen, Alexandra; Narayan, Julie] Environm Canada, Air Qual Processes Res Sci & Technol Branch, Toronto, ON M3H 5T4, Canada.
[Eckley, Chris S.] US EPA, Seattle, WA 98101 USA.
[Pilote, Martin] Environm Canada, Aquat Contaminants Res Div, Montreal, PQ H2Y 2E7, Canada.
[Tordon, Rob] Environm Canada, Dartmouth, NS B2Y 2N6, Canada.
[Graydon, Jennifer A.; St Louis, Vincent L.] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada.
[Xu, Xiaohong] Univ Windsor, Dept Civil & Environm Engn, Windsor, ON N9B 3P4, Canada.
[Branfireun, Brian A.] Univ Western Ontario, Dept Biol, London, ON N6A 5B7, Canada.
[Branfireun, Brian A.] Univ Western Ontario, Ctr Environm & Sustainabil, London, ON N6A 5B7, Canada.
RP Cole, AS (reprint author), Environm Canada, Air Qual Processes Res Sci & Technol Branch, 4905 Dufferin St, Toronto, ON M3H 5T4, Canada.
EM amanda.cole@ec.gc.ca; Alexandra.Steffen@ec.gc.ca; Eckley.Chris@epa.gov;
Julie.Narayan@ec.gc.ca; Martin.Pilote@ec.gc.ca; rob.tordon@ec.gc.ca;
jgraydon@ualberta.ca; vince.stlouis@ualberta.ca; xxu@uwindsor.ca;
bbranfir@uwo.ca
RI Graydon, Jennifer/G-6853-2011; St. Louis, Vincent/G-6842-2011; Pilote,
Martin/G-2581-2016;
OI Pilote, Martin/0000-0002-6874-5135; Cole, Amanda/0000-0002-5434-4998
FU Environment Canada (EC); Northern Contaminants Program (Aboriginal
Affairs and Northern Development Canada); Geological Survey of Canada;
Natural Sciences and Engineering Research Council; Government of Canada;
EC's Global Atmospheric Watch program; EC's Whistler program; Manitoba
Hydro
FX Funding for CAMNet and CAPMoN was provided by Environment Canada (EC).
Additional funding was provided by the Northern Contaminants Program
(Aboriginal Affairs and Northern Development Canada), the Geological
Survey of Canada, the Natural Sciences and Engineering Research Council,
the Government of Canada Program for International Polar Year, EC's
Global Atmospheric Watch program and Whistler program, and Manitoba
Hydro. Additional data was contributed by the Meteorological Service of
Canada Air Quality Unit in Edmonton and by Geoffrey Stupple. Thanks to
the numerous former and current scientists and technicians for CAMNet
and CAPMoN, particularly Steve Beauchamp, Cathy Banic, Keith Puckett for
the creation of CAMNet; to Patrick Lee for support at other EC sites; to
Greg Skelton and Tina Scherz for many years of data QC; to Mike Shaw for
the site map; and to Heather Morrison and Pierrette Blanchard for
coordinating this project for the Canadian Mercury Science Assessment.
NR 75
TC 12
Z9 13
U1 4
U2 31
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2073-4433
J9 ATMOSPHERE-BASEL
JI Atmosphere
PD SEP
PY 2014
VL 5
IS 3
BP 635
EP 668
DI 10.3390/atmos5030635
PG 34
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AQ8UZ
UT WOS:000343111900009
ER
PT J
AU Powers, CM
Gift, J
Lehmann, GM
AF Powers, Christina M.
Gift, Jeff
Lehmann, Geniece M.
TI Sparking Connections: Toward Better Linkages Between Research and Human
Health Policy-An Example with Multiwalled Carbon Nanotubes
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE comprehensive environmental assessment; engineered nanomaterials; risk
assessment; multiwalled carbon nanotubes; research planning
ID COMPREHENSIVE ENVIRONMENTAL ASSESSMENT; ENGINEERED NANOMATERIALS;
RISK-ASSESSMENT; TOXICITY; EXPOSURE; FUNCTIONALIZATION; NANOCOMPOSITES;
TOXICOLOGY; KNOWLEDGE; RELEASE
AB Risk assessment and subsequent risk management of environmental contaminants can benefit from early collaboration among researchers, risk assessors, and risk managers. The benefits of collaboration in research planning are particularly evident in light of (1) increasing calls to expand upon the risk assessment paradigm to include a greater focus on problem formulation and consideration of potential tradeoffs between risk management options, and (2) decreasing research budgets. Strategically connecting research planning to future decision making may be most critical in areas of emerging science for which data are often insufficient to clearly direct targeted research to support future risk assessment and management efforts. This article illustrates an application of the comprehensive environmental assessment approach to inform research planning for future risk assessment and management of one emerging material, multiwalled carbon nanotubes (MWCNTs). High-priority research areas identified for MWCNTs in flame-retardant coatings applied to upholstery textiles included the following: release across the product life cycle; environmental transport, transformation and fate in air, wastewater and sediment; exposure in human occupational and consumer groups; kinetics in the human body; impacts on human health and aquatic populations; and impacts on economic, social, and environmental resources. This article focuses on specific research questions related to human health and how these may connect to future risk assessments and risk management efforts. Such connections will support more effective collaborations across the scientific community and may inform the prioritization of research funding opportunities for emerging materials like MWCNTs.
C1 [Powers, Christina M.; Gift, Jeff; Lehmann, Geniece M.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lehmann, GM (reprint author), US EPA, MD B243-01,4930 Old Page Rd, Durham, NC 27703 USA.
EM Lehmann.Geniece@epa.gov
FU U.S. Environmental Protection Agency [EP-C-09-009, EP-W-09-004]
FX U.S. Environmental Protection Agency (EP-C-09-009, EP-W-09-004).
NR 62
TC 1
Z9 2
U1 3
U2 18
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD SEP
PY 2014
VL 141
IS 1
BP 6
EP 17
DI 10.1093/toxsci/kfu117
PG 12
WC Toxicology
SC Toxicology
GA AQ7JP
UT WOS:000342990200007
PM 24928890
ER
PT J
AU Hatch, GE
Duncan, KE
Diaz-Sanchez, D
Schmitt, MT
Ghio, AJ
Carraway, MS
McKee, J
Dailey, LA
Berntsen, J
Devlin, RB
AF Hatch, Gary E.
Duncan, Kelly E.
Diaz-Sanchez, David
Schmitt, Michael T.
Ghio, Andrew J.
Carraway, Martha Sue
McKee, John
Dailey, Lisa A.
Berntsen, Jon
Devlin, Robert B.
TI Progress in Assessing Air Pollutant Risks from In Vitro Exposures:
Matching Ozone Dose and Effect in Human Airway Cells
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE ozone; in vivo versus in vitro dose; extrapolation; epithelial cells;
bronchoalveolar lavage
ID BRONCHOALVEOLAR LAVAGE; RATS; O-18; INFLAMMATION; FLUID; LUNG
AB In vitro exposures to air pollutants could, in theory, facilitate a rapid and detailed assessment of molecular mechanisms of toxicity. However, it is difficult to ensure that the dose of a gaseous pollutant to cells in tissue culture is similar to that of the same cells during in vivo exposure of a living person. The goal of the present study was to compare the dose and effect of O-3 in airway cells of humans exposed in vivo to that of human cells exposed in vitro. Ten subjects breathed labeled O-3 (O-18(3), 0.3 ppm, 2 h) while exercising intermittently. Bronchial brush biopsies and lung lavage fluids were collected 1 h post exposure for in vivo data whereas in vitro data were obtained from primary cultures of human bronchial epithelial cells exposed to 0.25-1.0 ppm O-18(3) for 2 h. The O-3 dose to the cells was defined as the level of O-18 incorporation and the O-3 effect as the fold increase in expression of inflammatory marker genes (IL-8 and COX-2). Dose and effect in cells removed from in vivo exposed subjects were lower than in cells exposed to the same O-18(3) concentration in vitro suggesting upper airway O-3 scrubbing in vivo. Cells collected by lavage as well as previous studies in monkeys show that cells deeper in the lung receive a higher O-3 dose than cells in the bronchus. We conclude that the methods used herein show promise for replicating and comparing the in vivo dose and effect of O-3 in an in vitro system.
C1 [Hatch, Gary E.; Diaz-Sanchez, David; Schmitt, Michael T.; Ghio, Andrew J.; Carraway, Martha Sue; McKee, John; Dailey, Lisa A.; Devlin, Robert B.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Duncan, Kelly E.] Univ N Carolina, Sch Med, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA.
[Berntsen, Jon] TRC Environm Corp, Raleigh, NC 27606 USA.
RP Hatch, GE (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM hatch.gary@epa.gov
FU United States Environmental Protection Agency [CR833463-01]
FX United States Environmental Protection Agency intramural funds and a
cooperative agreement (CR833463-01) between the U.S. EPA and the Center
for Environmental Medicine, Asthma and Lung Biology at the University of
North Carolina at Chapel Hill.
NR 18
TC 7
Z9 7
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD SEP
PY 2014
VL 141
IS 1
BP 198
EP 205
DI 10.1093/toxsci/kfu115
PG 8
WC Toxicology
SC Toxicology
GA AQ7JP
UT WOS:000342990200024
PM 24928893
ER
PT J
AU Rudraiah, S
Rohrer, PR
Gurevich, I
Goedken, MJ
Rasmussen, T
Hines, RN
Manautou, JE
AF Rudraiah, Swetha
Rohrer, Philip R.
Gurevich, Igor
Goedken, Michael J.
Rasmussen, Theodore
Hines, Ronald N.
Manautou, Jose E.
TI Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of
Autoprotection Is Associated with Induction of Flavin-Containing
Monooxygenase-3 (FMO3) in Hepatocytes
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE acetaminophen; autoprotection; Fmo3; hepatotoxicity; inhibitor;
methimazole
ID INDUCED LIVER-INJURY; GENETIC POLYMORPHISMS; COVALENT BINDING;
DRUG-METABOLISM; CELL-DEATH; EXPRESSION; MICE; METHIMAZOLE; MECHANISMS;
GLUTATHIONE
AB Acetaminophen (APAP) pretreatment with a hepatotoxic dose (400 mg/kg) in mice results in resistance to a second, higher dose (600 mg/kg) of APAP (APAP autoprotection). Recent microarray work by our group showed a drastic induction of liver flavin containing monooxygenase-3 (Fmo3) mRNA expression in our mouse model of APAP autoprotection. The role of liver Fmo3, which detoxifies xenobiotics, in APAP autoprotection is unknown. The purpose of this study was to characterize the gene regulation and protein expression of liver Fmo3 during APAP hepatotoxicity. The functional consequences of Fmo3 induction were also investigated. Plasma and livers were collected from male C57BL/6J mice over a period of 72 h following a single dose of APAP (400 mg/kg) to measure Fmo3 mRNA and protein expression. Although Fmo3 mRNA levels increased significantly following APAP treatment, protein expression changed marginally. In contrast, both Fmo3 mRNA and protein expression were significantly higher in APAP autoprotected livers. Unlike male C57BL/6J mice, female mice have similar to 80-times higher constitutive Fmo3 mRNA levels and are highly resistant to APAP hepatotoxicity. Coadministration of APAP with the FMO inhibitor methimazole rendered female mice susceptible to APAP hepatotoxicity, with no changes in susceptibility detected in male mice. Furthermore, a human hepatocyte cell line (HC-04) clone over-expressing human FMO3 showed enhanced resistance to APAP cytotoxicity. Taken together, these findings establish for the first time induction of Fmo3 protein expression and function by xenobiotic treatment. Our results also indicate that Fmo3 expression and function plays a role in protecting the liver from APAP-induced toxicity. Although the mechanism(s) of this protection remains to be elucidated, this work describes a novel protective function for this enzyme.
C1 [Rudraiah, Swetha; Rohrer, Philip R.; Rasmussen, Theodore; Manautou, Jose E.] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06269 USA.
[Gurevich, Igor] Cellular Dynam Int, Madison, WI 53711 USA.
[Goedken, Michael J.] Rutgers State Univ, Off Translat Sci, New Brunswick, NJ 08901 USA.
[Hines, Ronald N.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Manautou, JE (reprint author), Univ Connecticut, Toxicol Program, Dept Pharmaceut Sci, Sch Pharm, 69 North Eagleville Rd,Unit 3092, Storrs, CT 06269 USA.
EM jose.manautou@uconn.edu
FU National Institutes of Health [DK069557]
FX National Institutes of Health Grant (DK069557).
NR 50
TC 6
Z9 6
U1 1
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD SEP
PY 2014
VL 141
IS 1
BP 263
EP 277
DI 10.1093/toxsci/kfu124
PG 15
WC Toxicology
SC Toxicology
GA AQ7JP
UT WOS:000342990200030
PM 24973094
ER
PT J
AU Ippolito, JA
Barbarick, KA
Brobst, RB
AF Ippolito, J. A.
Barbarick, K. A.
Brobst, R. B.
TI Copper and Zinc Speciation in a Biosolids-Amended, Semiarid Grassland
Soil
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID SLUDGE-TREATED SOILS; SEWAGE-SLUDGE; HEAVY-METALS; ORGANIC-MATTER;
HYDROUS OXIDES; BIOAVAILABILITY; MOBILITY; CADMIUM; BINDING; IRON
AB Predicting trace-metal solid-phase speciation changes associated with long-term biosolids land application is important for understanding and improving environmental quality. Biosolids were surface-applied (no incorporation; 0, 2.5, 5, 10, 21, and 30 Mg ha(-1)) to a semiarid grassland in 1991 (single application) and 2002 (repeated application). In July 2003, soils were obtained from the 0- to 8-, 8- to 15-, and 15 -to 30-cm depths in all plots. Using soil pH, soluble anion and cation concentrations from 0.01 mol L-1 CaCl2 extractions, dissolved organic C (DOC) content, and an estimate of solid phase humic and fulvic acids present, Cu and Zn associated with minerals, hydrous ferric oxides (HFO), organically complexed, electrostatically bound to organic matter (OM), or DOC phases was modeled using Visual Minteq. Scanning electron microscopy and energy-dispersive X-ray analysis (SEM-EDXRA) was also used to identify solid-phase metal associations present in single and repeated biosolids-amended soils. Based on soil solution chemistry in all depths, as modeled using Visual Minteq, >90% of the Cu and >95% of the Zn from the single or repeated biosolids-applied soils were sorbed electrostatically or as mono-or bidentate solid-phase OM complexes. Up to 10 and 5% of the Cu and Zn, respectively, was associated with HFO, with negligible amounts associated with DOC. The SEM-EDXRA of clay-sized separates from all soil depths led to direct observation of Fe-Cu and Fe-Zn associations. Results implied that after surface-applying biosolids either once or twice with up to 30 Mg ha(-1), some shifts occurred in phases controlling Cu and Zn solubility, but solution concentrations remained below drinking water standards.
C1 [Ippolito, J. A.] ARS, USDA, NWISRL, Kimberly, ID 83341 USA.
[Barbarick, K. A.] Colorado State Univ, Dep Soil & Crop Sci, Ft Collins, CO 80523 USA.
[Brobst, R. B.] US EPA, Denver, CO 80202 USA.
RP Ippolito, JA (reprint author), ARS, USDA, NWISRL, 3793 North 3600 East, Kimberly, ID 83341 USA.
EM jim.ippolito@ars.usda.gov
FU USEPA Region 8 [CP988928-01]
FX The USDA-ARS and Colorado State University gratefully acknowledge USEPA
Region 8 (Grant #CP988928-01) for its financial, technical, and
administrative assistance in funding and managing the project through
which this information was discovered. We thank the City of Fort
Collins, CO for their continued support of this project. We would also
like to thank Ms. Mary Ann Kay for providing much needed laboratory
support. The mention of firm names or trade products does not imply that
they are endorsed or recommended by USDA over other firms or similar
products not mentioned.
NR 50
TC 0
Z9 0
U1 2
U2 14
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD SEP-OCT
PY 2014
VL 43
IS 5
BP 1576
EP 1584
DI 10.2134/jeq2014.02.0074
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AQ9FQ
UT WOS:000343154200007
PM 25603243
ER
PT J
AU Momm, HG
Bingner, RL
Yuan, YP
Locke, MA
Wells, RR
AF Momm, Henrique G.
Bingner, Ronald L.
Yuan, Yongping
Locke, Martin A.
Wells, Robert R.
TI Spatial Characterization of Riparian Buffer Effects on Sediment Loads
from Watershed Systems
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID NONPOINT-SOURCE POLLUTION; VEGETATIVE FILTER STRIPS; ANNAGNPS MODEL;
AGRICULTURAL WATERSHEDS; QUALITY; FLOW; AGNPS; MANAGEMENT; PLACEMENT;
TRANSPORT
AB Understanding all watershed systems and their interactions is a complex, but critical, undertaking when developing practices designed to reduce topsoil loss and chemical/nutrient transport from agricultural fields. The presence of riparian buffer vegetation in agricultural landscapes can modify the characteristics of overland flow, promoting sediment deposition and nutrient filtering. Watershed simulation tools, such as the USDA-Annualized Agricultural Non-Point Source (AnnAGNPS) pollution model, typically require detailed information for each riparian buffer zone throughout the watershed describing the location, width, vegetation type, topography, and possible presence of concentrated flow paths through the riparian buffer zone. Research was conducted to develop GIS-based technology designed to spatially characterize riparian buffers and to estimate buffer efficiency in reducing sediment loads in a semiautomated fashion at watershed scale. The methodology combines modeling technology at different scales, at individual concentrated flow paths passing through the riparian zone, and at watershed scales. At the concentrated flow path scale, vegetative filter strip models are applied to estimate the sediment-trapping efficiency for each individual flow path, which are aggregated based on the watershed subdivision and used in the determination of the overall impact of the riparian vegetation at the watershed scale. This GIS-based technology is combined with AnnAGNPS to demonstrate the effect of riparian vegetation on sediment loadings from sheet and rill and ephemeral gully sources. The effects of variability in basic input parameters used to characterize riparian buffers, onto generated outputs at field scale (sediment trapping efficiency) and at watershed scale (sediment loadings from different sources) were evaluated and quantified. The AnnAGNPS riparian buffer component represents an important step in understanding and accounting for the effect of riparian vegetation, existing and/or managed, in reducing sediment loads at the watershed scale.
C1 [Momm, Henrique G.] Middle Tennessee State Univ, Dept Geosci, Murfreesboro, TN 37132 USA.
[Bingner, Ronald L.; Locke, Martin A.; Wells, Robert R.] ARS, USDA, Natl Sedimentat Lab, Oxford, MS USA.
[Yuan, Yongping] US EPA, Las Vegas, NV USA.
RP Momm, HG (reprint author), Middle Tennessee State Univ, Dept Geosci, Murfreesboro, TN 37132 USA.
EM henrique.momm@mtsu.edu
NR 47
TC 6
Z9 7
U1 10
U2 61
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD SEP-OCT
PY 2014
VL 43
IS 5
BP 1736
EP 1753
DI 10.2134/jeq2013.10.0413
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AQ9FQ
UT WOS:000343154200023
PM 25603259
ER
PT J
AU Valdivia, P
Martin, M
LeFew, WR
Ross, J
Houck, KA
Shafer, TJ
AF Valdivia, Pablo
Martin, Matt
LeFew, William R.
Ross, James
Houck, Keith A.
Shafer, Timothy J.
TI Multi-well microelectrode array recordings detect neuroactivity of
ToxCast compounds
SO NEUROTOXICOLOGY
LA English
DT Article
DE Screening; ToxCast; Microelectrode arrays; Electrophysiology
ID ADVERSE OUTCOME PATHWAYS; PYRETHROID INSECTICIDES; DEVELOPMENTAL
TOXICITY; SODIUM-CHANNELS; NEUROTOXICITY; CHEMICALS; NEURONS; BINDING;
MECHANISMS; FUNGICIDES
AB Spontaneous activity in neuronal cultures on microelectrode arrays (MEAs) is sensitive to effects of drugs, chemicals, and particles. Multi-well MEA (mwMEA) systems have increased throughput of MEAs, enabling their use for chemical screening. The present experiments examined a subset of EPA's ToxCast compounds for effects on spontaneous neuronal activity in primary cortical cultures using 48-well MEA plates. A first cohort of 68 compounds was selected from the ToxCast Phase I and II libraries; 37 were positive in one or more of 20 individual ToxCast Novascreen assays related to ion channels (NVS_IC), with the remainder selected based on known neuroactivity. A second cohort of 25 compounds was then tested with 20 originating from the ToxCast Phase I and II libraries (not hits in NVS_IC assays) and 5 known negatives from commercial vendors. Baseline activity (1 h) was recorded prior to exposing the networks to compounds for 1 h, and the weighted mean firing rate (wMFR) was determined in the absence and presence of each compound. Compounds that altered activity by greater than the weighted change of DMSO-treated wells plus 2SD were considered "hits". Of the first set of 68 compounds, 54 altered wMFR by more than the threshold, while in the second set, 13/25 compounds were hits. MEAs detected 30 of 37 (81.1%) compounds that were hits in NVS_IC assays, as well as detected known neurotoxicants that were negative in NVS_IC assays, primarily pyrethroids and GABA(A) receptor antagonists. Conversely, wMFR of cortical neuronal networks on MEAs was insensitive to nicotinic compounds, as only one neonicotinoid was detected by MEAs; this accounts for the bulk of non-concordant compounds between MEA and NVS_IC assays. These data demonstrate that mwMEAs can be used to screen chemicals efficiently for potential neurotoxicity, and that the results are concordant with predictions from ToxCast NVS_IC assays for interactions with ion channels. Published by Elsevier Inc.
C1 [Valdivia, Pablo; Ross, James] Axion Biosyst, Atlanta, GA USA.
[Martin, Matt; Houck, Keith A.] US EPA, Natl Ctr Computat Toxicol, ORD, Res Triangle Pk, NC 27711 USA.
[LeFew, William R.; Shafer, Timothy J.] US EPA, Integrated Syst Toxicol Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
RP Shafer, TJ (reprint author), US EPA, Integrated Syst Toxicol Div, MD-B105-03, Res Triangle Pk, NC 27711 USA.
EM Shafer.tim@epa.gov
OI Shafer, Timothy/0000-0002-8069-9987
FU US EPA Office of Research and Development; Axion Biosystems [CRADA
644-11]; U.S. Environmental Protection Agency
FX This work was conducted as part of a Cooperative Research and
Development Agreement between the US EPA Office of Research and
Development and Axion Biosystems (CRADA 644-11). Preparation of this
document has been funded by the U.S. Environmental Protection Agency.
This document has been reviewed by the National Health and Environmental
Effects Research Laboratory and approved for publication. Approval does
not signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 41
TC 20
Z9 20
U1 3
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD SEP
PY 2014
VL 44
BP 204
EP 217
DI 10.1016/j.neuro.2014.06.012
PG 14
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA AQ2XY
UT WOS:000342654500023
PM 24997244
ER
PT J
AU Brooks, WR
Newbold, SC
AF Brooks, Wesley R.
Newbold, Stephen C.
TI An updated biodiversity nonuse value function for use in climate change
integrated assessment models
SO ECOLOGICAL ECONOMICS
LA English
DT Article
DE Biodiversity; Climate change; Ecosystem; Integrated assessment model;
Nonuse value; Structural benefit transfer
ID WILLINGNESS-TO-PAY; DAMAGE COSTS; RESPONSES; PLANTS
AB The impacts on biodiversity and ecosystems are among the key reasons for concern about climate change. Integrated assessment models are the main tools used to estimate the global economic benefits of policies that would address climate change, but these models typically include only a partial accounting and idiosyncratic treatment of ecosystem impacts. Here, we review several recent studies of the impacts of climate change on biodiversity and show that the biodiversity value function in the FUND integrated assessment model is insensitive to predicted biodiversity loss, instead depending almost entirely on temperature changes per se. We use quantitative estimates of the influence of global warming on species extinction rates to re-calibrate the biodiversity loss function in FUND, and develop a new global biodiversity nonuse value function calibrated using results from two previous studies of people's willingness to pay to prevent the loss of tropical rainforests and to protect endangered species in the US. In contrast to the ecosystem damages function in FUND, our biodiversity value function depends on temperature only indirectly through its influence on biodiversity loss. Finally, we highlight areas where further research is needed for developing more comprehensive and reliable forecasts of ecosystem damages related to climate change. Published by Elsevier B.V.
C1 [Brooks, Wesley R.] Rutgers State Univ, Dept Ecol Evolut & Nat Resources, New Brunswick, NJ 08901 USA.
[Newbold, Stephen C.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Newbold, SC (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
EM wrbrooks@gmail.com; newbold.steve@epa.gov
OI Brooks, Wesley/0000-0002-2927-0464
NR 44
TC 0
Z9 0
U1 1
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-8009
EI 1873-6106
J9 ECOL ECON
JI Ecol. Econ.
PD SEP
PY 2014
VL 105
BP 342
EP 349
DI 10.1016/j.ecolecon.2014.06.015
PG 8
WC Ecology; Economics; Environmental Sciences; Environmental Studies
SC Environmental Sciences & Ecology; Business & Economics
GA AP7QU
UT WOS:000342272600034
ER
PT J
AU Rappazzo, KM
Daniels, JL
Messer, LC
Poole, C
Lobdell, DT
AF Rappazzo, Kristen M.
Daniels, Julie L.
Messer, Lynne C.
Poole, Charles
Lobdell, Danelle T.
TI Exposure to Fine Particulate Matter during Pregnancy and Risk of Preterm
Birth among Women in New Jersey, Ohio, and Pennsylvania, 2000-2005
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID AMBIENT AIR-POLLUTION; UNITED-STATES; LOS-ANGELES; OUTCOMES; CALIFORNIA;
WEIGHT; PM2.5; PREMATURITY; MORTALITY; COHORT
AB Background: Particulate matter <= 2.5 mu m in aerodynamic diameter (PM2.5) has been variably associated with preterm birth (PTB).
OBJECTIVE: We classified PTB into four categories (20-27, 28-31, 32-34, and 35-36 weeks completed gestation) and estimated risk differences (RDs) for each category in association with a 1-mu g/m(3) increase in PM2.5 exposure during each week of gestation.
METHODS: We assembled a cohort of singleton pregnancies that completed >= 20 weeks of gestation during 2000-2005 using live birth certificate data from three states (Pennsylvania, Ohio, and New Jersey) (n = 1,940,213; 8% PTB). We estimated mean PM2.5 exposures for each week of gestation from monitor-corrected Community Multi-Scale Air Quality modeling data. RDs were estimated using modified Poisson linear regression and adjusted for maternal race/ethnicity, marital status, education, age, and ozone.
RESULTS: RD estimates varied by exposure window and outcome period. Average PM2.5 exposure during the fourth week of gestation was positively associated with all PTB outcomes, although magnitude varied by PTB category [e. g., for a 1-mu g/m(3) increase, RD = 11.8 (95% CI: -6, 29.2); RD = 46 (95% CI: 23.2, 68.9); RD = 61.1 (95% CI: 22.6, 99.7); and RD = 28.5 (95% CI: -39, 95.7) for preterm births during 20-27, 28-31, 32-34, and 35-36 weeks, respectively]. Exposures during the week of birth and the 2 weeks before birth also were positively associated with all PTB categories.
CONCLUSIONS: Exposures beginning around the time of implantation and near birth appeared to be more strongly associated with PTB than exposures during other time periods. Because particulate matter exposure is ubiquitous, evidence of effects of PM2.5 exposure on PTB, even if small in magnitude, is cause for concern.
C1 [Rappazzo, Kristen M.; Daniels, Julie L.; Poole, Charles] Univ N Carolina, UNC Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
[Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community, Portland, OR 97207 USA.
[Lobdell, Danelle T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Rappazzo, KM (reprint author), UNC Gillings Sch Global Publ Hlth, Dept Epidemiol, CB 7435, Chapel Hill, NC 27514 USA.
EM Rappazzo.kristen@epa.gov
NR 46
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Z9 16
U1 1
U2 8
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD SEP
PY 2014
VL 122
IS 9
BP 992
EP 997
DI 10.1289/ehp.1307456
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AO9XT
UT WOS:000341714600029
PM 24879653
ER
PT J
AU Isakov, V
Arunachalam, S
Batterman, S
Bereznicki, S
Burke, J
Dionisio, K
Garcia, V
Heist, D
Perry, S
Snyder, M
Vette, A
AF Isakov, Vlad
Arunachalam, Saravanan
Batterman, Stuart
Bereznicki, Sarah
Burke, Janet
Dionisio, Kathie
Garcia, Val
Heist, David
Perry, Steve
Snyder, Michelle
Vette, Alan
TI Air Quality Modeling in Support of the Near-Road Exposures and Effects
of Urban Air Pollutants Study (NEXUS)
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE dispersion modeling; air pollution; exposure; traffic
ID LONG-TERM EXPOSURE; POLLUTION EXPOSURE; DISPERSION MODEL; FORMULATION;
PROXIMITY; MORTALITY; PROJECT; ATLANTA; DESIGN; HEALTH
AB A major challenge in traffic-related air pollution exposure studies is the lack of information regarding pollutant exposure characterization. Air quality modeling can provide spatially and temporally varying exposure estimates for examining relationships between traffic-related air pollutants and adverse health outcomes. A hybrid air quality modeling approach was used to estimate exposure to traffic-related air pollutants in support of the Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS) conducted in Detroit (Michigan, USA). Model-based exposure metrics, associated with local variations of emissions and meteorology, were estimated using a combination of the American Meteorological Society/Environmental Protection Agency Regulatory Model (AERMOD) and Research LINE-source dispersion model for near-surface releases (RLINE) dispersion models, local emission source information from the National Emissions Inventory, detailed road network locations and traffic activity, and meteorological data from the Detroit City Airport. The regional background contribution was estimated using a combination of the Community Multi-scale Air Quality (CMAQ) and the Space-Time Ordinary Kriging (STOK) models. To capture the near-road pollutant gradients, refined "mini-grids" of model receptors were placed around participant homes. Exposure metrics for CO, NOx, PM2.5 and its components (elemental and organic carbon) were predicted at each home location for multiple time periods including daily and rush hours. The exposure metrics were evaluated for their ability to characterize the spatial and temporal variations of multiple ambient air pollutants compared to measurements across the study area.
C1 [Isakov, Vlad; Bereznicki, Sarah; Burke, Janet; Dionisio, Kathie; Garcia, Val; Heist, David; Perry, Steve; Vette, Alan] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Arunachalam, Saravanan; Snyder, Michelle] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA.
[Batterman, Stuart] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
RP Isakov, V (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Isakov.Vlad@epa.gov; sarav@unc.edu; stuartb@umich.edu;
sarah.bereznicki@gmail.com; Burke.janet@epa.gov;
Dionisio.Kathie@epa.gov; Garcia.Val@epa.gov; Heist.David@epa.gov;
Perry.Steven@epa.gov; mgs3584@email.unc.edu; Vette.Alan@epa.gov
FU US Environmental Protection Agency through its Office of Research and
Development [R834117]
FX We thank Gary Norris, Carry Croghan and Rich Cook at US EPA, Laprisha
Berry Vaughn, Sonya Grant, Chris Godwin, Graciela Mentz, Xiaodan Ren,
Irme Cuadros and other staff at the University of Michigan, and Brian
Naess, Mohammad Omary, Kevin Talgo, Alejandro Valencia, Yasuyuki Akita
and Marc Serre of the University of North Carolina at Chapel Hill. We
are grateful to the NEXUS participants and their families who assisted
us with the collection of these data. Community Action Against Asthma is
a community-based participatory research partnership aimed at
investigating the influence of environmental factors on childhood
asthma. We acknowledge the contributions of all of the partners involved
in this collaborative effort: Arab Community Center for Economic and
Social Services; Community Health & Social Services Center; Detroit
Department of Health and Wellness Promotion; Detroit Hispanic
Development Corporation; Detroiters Working for Environmental Justice;
Friends of Parkside; Latino Family Services; Southwest Detroit
Environmental Vision; Warren/Conner Development Coalition; Institute for
Population Health, and the University of Michigan Schools of Public
Health and Medicine. The US Environmental Protection Agency through its
Office of Research and Development partially funded the research
described here under cooperative agreement R834117 (University of
Michigan). It has been subjected to Agency review and approved for
publication.
NR 30
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Z9 7
U1 4
U2 35
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2014
VL 11
IS 9
BP 8777
EP 8793
DI 10.3390/ijerph110908777
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AP4DN
UT WOS:000342027500011
PM 25166917
ER
PT J
AU Batterman, S
Burke, J
Isakov, V
Lewis, T
Mukherjee, B
Robins, T
AF Batterman, Stuart
Burke, Janet
Isakov, Vlad
Lewis, Toby
Mukherjee, Bhramar
Robins, Thomas
TI A Comparison of Exposure Metrics for Traffic-Related Air Pollutants:
Application to Epidemiology Studies in Detroit, Michigan
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE air pollution; dispersion modeling; epidemiology; exhaust; exposure
misclassification; PM2.5; traffic; vehicle
ID NEAR-ROAD; POLLUTION EPIDEMIOLOGY; ULTRAFINE PARTICLES; DISPERSION;
QUALITY; MODELS; HEALTH; EMISSIONS; DOWNWIND; RALEIGH
AB Vehicles are major sources of air pollutant emissions, and individuals living near large roads endure high exposures and health risks associated with traffic-related air pollutants. Air pollution epidemiology, health risk, environmental justice, and transportation planning studies would all benefit from an improved understanding of the key information and metrics needed to assess exposures, as well as the strengths and limitations of alternate exposure metrics. This study develops and evaluates several metrics for characterizing exposure to traffic-related air pollutants for the 218 residential locations of participants in the NEXUS epidemiology study conducted in Detroit (MI, USA). Exposure metrics included proximity to major roads, traffic volume, vehicle mix, traffic density, vehicle exhaust emissions density, and pollutant concentrations predicted by dispersion models. Results presented for each metric include comparisons of exposure distributions, spatial variability, intraclass correlation, concordance and discordance rates, and overall strengths and limitations. While showing some agreement, the simple categorical and proximity classifications (e. g., high diesel/low diesel traffic roads and distance from major roads) do not reflect the range and overlap of exposures seen in the other metrics. Information provided by the traffic density metric, defined as the number of kilometers traveled (VKT) per day within a 300 m buffer around each home, was reasonably consistent with the more sophisticated metrics. Dispersion modeling provided spatially- and temporally-resolved concentrations, along with apportionments that separated concentrations due to traffic emissions and other sources. While several of the exposure metrics showed broad agreement, including traffic density, emissions density and modeled concentrations, these alternatives still produced exposure classifications that differed for a substantial fraction of study participants, e. g., from 20% to 50% of homes, depending on the metric, would be incorrectly classified into "low", "medium" or "high" traffic exposure classes. These and other results suggest the potential for exposure misclassification and the need for refined and validated exposure metrics. While data and computational demands for dispersion modeling of traffic emissions are non-trivial concerns, once established, dispersion modeling systems can provide exposure information for both on- and near-road environments that would benefit future traffic-related assessments.
C1 [Batterman, Stuart; Robins, Thomas] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Burke, Janet; Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Lewis, Toby] Univ Michigan, Sch Med, Dept Pediat Pulm, Ann Arbor, MI 48109 USA.
[Mukherjee, Bhramar] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
RP Batterman, S (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1420 Washington Hts, Ann Arbor, MI 48109 USA.
EM stuartb@umich.edu; burke.janet@epa.gov; isakov.vlad@epa.gov;
tobyl@med.umich.edu; bhramar@umich.edu; trobins@umich.edu
FU Office of Research and Development at the U.S. Environmental Protection
Agency [R834117]; National Institute of Environmental Health Sciences
(NIEHS) [5R01 ESO14677-02, R01 ES016769-01]; NIEHS [P30ES017885]; United
States Environmental Protection Agency (EPA) [R-82811201]
FX Funding sources that supported this research included the Office of
Research and Development at the U.S. Environmental Protection Agency
under cooperative agreement R834117 (University of Michigan), and the
National Institute of Environmental Health Sciences (NIEHS) through
grants 5R01 ESO14677-02 and R01 ES016769-01 for NEXUS. NIEHS provided
additional support in grant P30ES017885 "Lifestage exposures and adult
disease". This article has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Portions of the research in this article were conducted under contract
to the Health Effects Institute (HEI), an organization jointly funded by
the United States Environmental Protection Agency (EPA) (Assistance
Award No. R-82811201) and certain motor vehicle and engine
manufacturers. The contents of this article do not necessarily reflect
the views of HEI, or its sponsors, nor do they necessarily reflect the
views and policies of the EPA or motor vehicle and engine manufacturers.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 37
TC 10
Z9 10
U1 2
U2 29
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2014
VL 11
IS 9
BP 9553
EP 9577
DI 10.3390/ijerph110909553
PG 25
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AP4DN
UT WOS:000342027500056
PM 25226412
ER
PT J
AU Lu, J
Buse, HY
Gomez-Alvarez, V
Struewing, I
Santo Domingo, J
Ashbolt, NJ
AF Lu, J.
Buse, H. Y.
Gomez-Alvarez, V.
Struewing, I.
Santo Domingo, J.
Ashbolt, N. J.
TI Impact of drinking water conditions and copper materials on downstream
biofilm microbial communities and Legionella pneumophila colonization
SO JOURNAL OF APPLIED MICROBIOLOGY
LA English
DT Article
DE biofilm; downstream; Legionella pneumophila; microbial community; pipe
material
ID FREE-LIVING AMEBAS; UNPLASTICIZED POLYVINYLCHLORIDE;
DISTRIBUTION-SYSTEMS; RESISTING BACTERIA; PLUMBING MATERIALS; PIPE
MATERIALS; IDENTIFICATION; ACANTHAMOEBA; PCR; BIODIVERSITY
AB Aims: This study examined the impact of pipe materials and introduced Legionella pneumophila on downstream Leg. pneumophila colonization and microbial community structures under conditions of low flow and low chlorine residual.
Methods and Results: CDC biofilm (TM) reactors containing either unplasticized polyvinylchloride (uPVC) or copper (Cu) coupons were used to develop mature biofilms on Norprene (TM) tubing effluent lines to simulate possible in-premise biofilm conditions. The microbial communities were characterized through 16S and 18S rRNA gene clone libraries and Leg. pneumophila colonization was determined via specific qPCR assays. The Cu significantly decreased downstream microbial diversity, approximately halved bacterial and eukaryotic abundance, with some groups only detected in uPVC-reactor tubing biofilms. However, some probable amoeba-resisting bacteria (ARB) like Mycobacterium spp. and Rhodobacteraceae were significantly more abundant in the Cu than uPVC-reactor tubing biofilms. In particular, Leg. pneumophila only persisted (postinoculation) within the Cu-reactor tubing biofilms, and the controlled low chlorine residue and water flow conditions led to a general high abundance of possible free-living protozoa in all tubing biofilms. The higher relative abundance of ARB-like sequences from Cu-coupons vs uPVC may have been promoted by amoebal selection and subsequent ARB protection from Cu inhibitory effects.
Conclusions: Copper pipe and low flow conditions had significant impact on downstream biofilm microbial structures (on plastic pipe) and the ability for Leg. pneumophila colonization post an introduction event.
Significance and Impact of the Study: This is the first report that compares the effects of copper and uPVC materials on downstream biofilm communities grown on a third (Norprene (TM)) surface material. The downstream biofilms contained a high abundance of free-living amoebae and ARB, which may have been driven by a lack of residual disinfectant and periodic stagnant conditions. Given the prevalence of Cu-piping in buildings, there may be increased risk from drinking water exposures to ARB following growth on pipe/fixture biofilms within premise drinking water systems.
C1 [Lu, J.; Gomez-Alvarez, V.; Santo Domingo, J.; Ashbolt, N. J.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Buse, H. Y.; Struewing, I.] Dynamac Inc, Cincinnati, OH USA.
RP Lu, J (reprint author), Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM lu.jingrang@epa.gov
FU Pathfinder Innovation Project - Office of Research and Development,
United States Environmental Protection Agency (U.S. EPA)
FX This research was supported by the Pathfinder Innovation Project -
Funded by the Office of Research and Development, United States
Environmental Protection Agency (U.S. EPA). The views expressed in this
article are those of the author(s) and do not necessarily represent the
views or policies of the U.S. Environmental Protection Agency. Mention
of trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 58
TC 9
Z9 9
U1 7
U2 57
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1364-5072
EI 1365-2672
J9 J APPL MICROBIOL
JI J. Appl. Microbiol.
PD SEP
PY 2014
VL 117
IS 3
BP 905
EP 918
DI 10.1111/jam.12578
PG 14
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AP6VE
UT WOS:000342215300029
PM 24935752
ER
PT J
AU Anenberg, SC
West, JJ
Yu, HB
Chin, M
Schulz, M
Bergmann, D
Bey, I
Bian, HS
Diehl, T
Fiore, A
Hess, P
Marmer, E
Montanaro, V
Park, R
Shindell, D
Takemura, T
Dentener, F
AF Anenberg, Susan C.
West, J. Jason
Yu, Hongbin
Chin, Mian
Schulz, Michael
Bergmann, Dan
Bey, Isabelle
Bian, Huisheng
Diehl, Thomas
Fiore, Arlene
Hess, Peter
Marmer, Elina
Montanaro, Veronica
Park, Rokjin
Shindell, Drew
Takemura, Toshihiko
Dentener, Frank
TI Impacts of intercontinental transport of anthropogenic fine particulate
matter on human mortality
SO AIR QUALITY ATMOSPHERE AND HEALTH
LA English
DT Article
DE Health impact assessment; Particulate matter; Long-range transport;
Chemical transport modeling
ID REGIONAL AIR-QUALITY; MULTIMODEL ASSESSMENT; EMISSION CONTROLS; GLOBAL
BURDEN; UNITED-STATES; POLLUTION; AEROSOL; OZONE; EXPOSURE; VISIBILITY
AB Fine particulate matter with diameter of 2.5 mu m or less (PM2.5) is associated with premature mortality and can travel long distances, impacting air quality and health on intercontinental scales. We estimate the mortality impacts of 20 % anthropogenic primary PM2.5 and PM2.5 precursor emission reductions in each of four major industrial regions (North America, Europe, East Asia, and South Asia) using an ensemble of global chemical transport model simulations coordinated by the Task Force on Hemispheric Transport of Air Pollution and epidemiologically-derived concentration-response functions. We estimate that while 93-97 % of avoided deaths from reducing emissions in all four regions occur within the source region, 3-7 % (11,500; 95 % confidence interval, 8,800-14,200) occur outside the source region from concentrations transported between continents. Approximately 17 and 13 % of global deaths avoided by reducing North America and Europe emissions occur extraregionally, owing to large downwind populations, compared with 4 and 2 % for South and East Asia. The coarse resolution global models used here may underestimate intraregional health benefits occurring on local scales, affecting these relative contributions of extraregional versus intraregional health benefits. Compared with a previous study of 20 % ozone precursor emission reductions, we find that despite greater transport efficiency for ozone, absolute mortality impacts of intercontinental PM2.5 transport are comparable or greater for neighboring source-receptor pairs, due to the stronger effect of PM2.5 on mortality. However, uncertainties in modeling and concentration-response relationships are large for both estimates.
C1 [Anenberg, Susan C.] US EPA, Washington, DC 20460 USA.
[West, J. Jason] Univ N Carolina, Chapel Hill, NC USA.
[Yu, Hongbin] Univ Maryland, College Pk, MD 20742 USA.
[Chin, Mian; Bian, Huisheng; Diehl, Thomas] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Schulz, Michael] Norwegian Meteorol Inst, Oslo, Norway.
[Bergmann, Dan] Lawrence Livermore Natl Lab, Livermore, CA USA.
[Bey, Isabelle] Swiss Fed Inst Technol, Zurich, Switzerland.
[Diehl, Thomas] Univ Space Res Assoc, Columbia, MD USA.
[Fiore, Arlene] Columbia Univ, Lamont Doherty Geol Observ, Palisades, NY 10964 USA.
[Hess, Peter] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY USA.
[Marmer, Elina] Univ Hamburg, Dept Educ, Hamburg, Germany.
[Montanaro, Veronica] Univ Aquila, I-67100 Laquila, Italy.
[Park, Rokjin] Seoul Natl Univ, Seoul, South Korea.
[Shindell, Drew] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
[Shindell, Drew] Columbia Earth Inst, New York, NY USA.
[Takemura, Toshihiko] Kyushu Univ, Appl Mech Res Inst, Fukuoka 8168580, Japan.
[Dentener, Frank] Commiss European Communities, Joint Res Ctr, Inst Environm & Sustainabil, I-21020 Ispra, Italy.
RP Anenberg, SC (reprint author), US EPA, 1200 Penn Ave NW MC6301A, Washington, DC 20460 USA.
EM anenberg.susan@epa.gov
RI Yu, Hongbin/C-6485-2008; Takemura, Toshihiko/C-2822-2009; Kyushu,
RIAM/F-4018-2015; West, Jason/J-2322-2015; Park, Rokjin/I-5055-2012;
Shindell, Drew/D-4636-2012; Schulz, Michael/A-6930-2011; U-ID,
Kyushu/C-5291-2016; Chin, Mian/J-8354-2012
OI Yu, Hongbin/0000-0003-4706-1575; Takemura,
Toshihiko/0000-0002-2859-6067; West, Jason/0000-0001-5652-4987; Park,
Rokjin/0000-0001-8922-0234; Schulz, Michael/0000-0003-4493-4158;
FU NASA; US Department of Energy (BER) at LLNL [DE-AC5207NA27344]
FX The opinions expressed in this article are the authors' and do not
necessarily represent those of their employers, including the USEPA.
Model simulations were performed under the UN ECE Task Force on
Hemispheric Transport of Air Pollution. H. Y. was supported by the NASA
Atmospheric Composition Modeling and Analysis Program administered by R.
Eckman. D. B. was supported by the US Department of Energy (BER) at LLNL
under contract DE-AC5207NA27344.
NR 48
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U1 7
U2 40
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1873-9318
EI 1873-9326
J9 AIR QUAL ATMOS HLTH
JI Air Qual. Atmos. Health
PD SEP
PY 2014
VL 7
IS 3
BP 369
EP 379
DI 10.1007/s11869-014-0248-9
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO8GP
UT WOS:000341592100011
ER
PT J
AU Li, ZW
Clark, RM
Buchberger, SG
Yang, YJ
AF Li, Zhiwei
Clark, Robert M.
Buchberger, Steven G.
Yang, Y. Jeffrey
TI Evaluation of Climate Change Impact on Drinking Water Treatment Plant
Operation
SO JOURNAL OF ENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Climate change; Impact; Evaluation; Water treatment plants; Monte Carlo
method
ID QUALITY
AB This paper describes a technique for evaluating the impact of climate change on drinking water treatment operations and for applying engineering principles to minimize those impacts. The U.S. Environmental Protection Agency (USEPA) Water Treatment Plant model was modified, validated, and applied to a case study based on the Greater Cincinnati Water Works' Richard Miller treatment plant to provide quantitative measures of these impacts. Multivariate Monte Carlo experiments were executed to simulate and track performance of the Miller plant subject to nine jointly distributed source water quality parameters under both current and potential future hydrologic conditions. Results from the case study indicate a risk that finished water may exceed critical total organic carbon (TOC) levels, leading to potential violations of disinfection by-product regulations under plausible future scenarios. The future risk, however, can be managed with operational adjustments at the water treatment plant, such as increasing the frequency of granular activated carbon reactivation. Utility costs associated with the operation adjustments were expressed as cost curves. The approach presented in this paper can be useful for evaluating climate change impacts and for planning infrastructure and operational adaptation. (C) 2014 American Society of Civil Engineers.
C1 [Li, Zhiwei] Carbon Capture Sci Ltd Liabil Co, South Pk, PA 15129 USA.
[Li, Zhiwei; Buchberger, Steven G.] Univ Cincinnati, Environm Engn Program, Cincinnati, OH 45221 USA.
[Clark, Robert M.] Engn & Publ Hlth Consultant, Cincinnati, OH 45242 USA.
[Yang, Y. Jeffrey] US EPA, ORD NRMRL WSWRD, Cincinnati, OH 45268 USA.
RP Li, ZW (reprint author), Carbon Capture Sci Ltd Liabil Co, 4000 Brownsville Rd, South Pk, PA 15129 USA.
EM zhiweili@carboncapturescientific.com; rmclark@fuse.net;
steven.buchberger@uc.edu; Yang.Jeff@epa.gov
FU USEPA [EP-C-05-056]
FX This study is part of the Water Resources Adaptation Program
(WRAP)-Infrastructure supported by USEPA under contract EP-C-05-056. The
research described in this paper has been subjected to the Agency
administrative review and has been approved for external publication.
Any opinions expressed in this paper are those of the authors and do not
necessarily reflect the views of the Agency; therefore, no official
endorsement should be inferred. The authors are grateful for assistance
and cooperation from the following individuals: Jeff Swertfeger, Jeff
Vogt, and Yeongho Lee of the Greater Cincinnati Water Works; Warren
Swanson of Schmueser, Gordon and Meyer; Alexa Obolensky of the
Philadelphia Water Department; Greg Carroll, Alison Dugan, Pat Fair, and
Steve Allgeier of EPA's Office of Ground Water and Drinking Water; and
Jeff Adams, Hiba Ernst, and John Lipscomb of EPA's Office of Research
and Development.
NR 21
TC 3
Z9 3
U1 4
U2 23
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9372
EI 1943-7870
J9 J ENVIRON ENG
JI J. Environ. Eng.-ASCE
PD SEP
PY 2014
VL 140
IS 9
SI SI
AR UNSP A4014005
DI 10.1061/(ASCE)EE.1943-7870.0000824
PG 9
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP7AP
UT WOS:000342230200008
ER
PT J
AU Zhu, DZ
Yang, YJ
AF Zhu, David Z.
Yang, Y. Jeffrey
TI Special Issue on Drinking Water Safety, Security, and Sustainability
Introduction
SO JOURNAL OF ENVIRONMENTAL ENGINEERING
LA English
DT Editorial Material
C1 [Zhu, David Z.] Zhejiang Univ, Dept Civil Engn, Hangzhou 315058, Zhejiang, Peoples R China.
[Zhu, David Z.] Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB T6G 2W2, Canada.
[Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Zhu, DZ (reprint author), Zhejiang Univ, Dept Civil Engn, Hangzhou 315058, Zhejiang, Peoples R China.
EM david.zhu@ualberta.ca
NR 0
TC 0
Z9 0
U1 2
U2 10
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9372
EI 1943-7870
J9 J ENVIRON ENG
JI J. Environ. Eng.-ASCE
PD SEP
PY 2014
VL 140
IS 9
SI SI
AR UNSP A2014001
DI 10.1061/(ASCE)EE.1943-7870.0000865
PG 1
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AP7AP
UT WOS:000342230200001
ER
PT J
AU Reavie, ED
Barbiero, RP
Allinger, LE
Warren, GJ
AF Reavie, Euan D.
Barbiero, Richard P.
Allinger, Lisa E.
Warren, Glenn J.
TI Phytoplankton trends in the Great Lakes, 2001-2011
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Diatoms; Phytoplankton; Trend analysis; Algae; Water quality; Food webs
ID SILICEOUS MICROFOSSIL SUCCESSION; ZOOPLANKTON COMMUNITY; SPECIES
COMPOSITION; LOADING ANALYSIS; MASS-BALANCE; MICHIGAN; ERIE; ONTARIO;
HURON; DIATOMS
AB We describe recent trends in phytoplankton composition and abundance in the Laurentian Great Lakes using synoptic spring (April) and summer (August) sampling events from 2001 through 2011, a period of rapid shifts in pelagic food webs and water quality. Data analysis identified qualitative and quantitative changes in algal densities, biovolume, and taxonomic composition of assemblages. Since 2001, Lake Superior has changed subtly with an increase in small-celled blue-green algae in spring and a recent decline in summer centric diatoms, possibly a result of lake warming and changes in water quality. Spring phytoplankton declines mainly attributed to diatoms occurred in Lakes Huron and Michigan, a probable result of invasions by non-native dreissenids that have reduced pelagic nutrients and selectively consumed certain taxa. The decline in Lake Huron's spring phytoplankton biovolume was earlier and more severe than that in Lake Michigan, despite a faster and more abundant dreissenid invasion in Lake Michigan. Lake Erie's central basin had a notable increase in spring centric diatoms (largely Aulacoseira), while the whole of Lake Erie shows a summer increase in cyanobacteria, complementing that found in coastal regions. The composition of Lake Ontario's species assemblage shifted, but little overall change in algal abundance was observed with the exception of higher summer densities of cyanophytes. Additional mechanisms for shifts in the pelagic primary producers are described or hypothesized in the context of concurrent shifts in water quality and invertebrate populations. Tracking these trends and explaining driving factors will be critical to the management of lake conditions. (C) 2014 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved.
C1 [Reavie, Euan D.; Allinger, Lisa E.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA.
[Barbiero, Richard P.] CSC, Chicago, IL 60660 USA.
[Barbiero, Richard P.] Loyola Univ Chicago, Chicago, IL 60660 USA.
[Warren, Glenn J.] US EPA, Great Lakes Natl Program Off, Chicago, IL 60604 USA.
RP Reavie, ED (reprint author), Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, 5013 Miller Trunk Highway, Duluth, MN 55811 USA.
EM ereavie@d.umn.edu; gloeotri@sbcglobal.net; lallinge@d.umn.edu;
warren.glenn@epa.gov
OI Reavie, Euan/0000-0001-8871-5809
FU U.S. Environmental Protection Agency [GL-00E23101-2]
FX Michael Agbeti and Elaine Ruzycki supported algal assessments of the
GLNPO phytoplankton samples. Kitty Kennedy, Amy Kireta, and the crew of
the R/V Lake Guardian supported sample collection. This research was
supported by a grant to E. Reavie from the U.S. Environmental Protection
Agency under Cooperative Agreement GL-00E23101-2. This document has not
been subjected to the EPA's required peer and policy review and
therefore does not necessarily reflect the view of the Agency, and no
official endorsement should be inferred. This is contribution number 567
of the Center for Water and the Environment, Natural Resources Research
Institute, University of Minnesota Duluth.
NR 69
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U1 10
U2 79
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD SEP
PY 2014
VL 40
IS 3
BP 618
EP 639
DI 10.1016/j.jglr.2014.04.013
PG 22
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AP4GF
UT WOS:000342034500018
ER
PT J
AU Govindaraju, RS
McCuen, RH
Hantush, MM
AF Govindaraju, R. S.
McCuen, R. H.
Hantush, M. M.
TI Publishing in the Journal of Hydrologic Engineering (Retracted article.
See vol. 20, 08215002, 2015)
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Editorial Material
C1 [Govindaraju, R. S.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
[McCuen, R. H.] Univ Maryland, Dept Civil & Environm Engn, College Pk, MD 20742 USA.
[Hantush, M. M.] US EPA, USEPA Natl Risk Management Lab, Cincinnati, OH 45268 USA.
RP McCuen, RH (reprint author), Univ Maryland, Dept Civil & Environm Engn, College Pk, MD 20742 USA.
EM rhmccuen@eng.umd.edu
NR 0
TC 1
Z9 1
U1 4
U2 6
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
EI 1943-5584
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD SEP
PY 2014
VL 19
IS 9
AR 01814001
DI 10.1061/(ASCE)HE.1943-5584.0001031
PG 1
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AP7AC
UT WOS:000342228800001
ER
PT J
AU Hantush, MM
Chaudhary, A
AF Hantush, Mohamed M.
Chaudhary, Abhishek
TI Bayesian Framework for Water Quality Model Uncertainty Estimation and
Risk Management
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
DE Water quality; Model; Uncertainty; Bayes; Monte Carlo; Calibration;
Maximum likelihood; Risk management; Total maximum daily load (TMDL);
Margin of safety
ID TMDL DEVELOPMENT; EQUIFINALITY; SAFETY; MARGIN
AB A formal Bayesian methodology is presented for integrated model calibration and risk-based water quality management using Bayesian Monte Carlo simulation and maximum likelihood estimation (BMCML). The primary focus is on lucid integration of model calibration with risk-based water quality management and total maximum daily load (TMDL) estimation under conditions of uncertainty. The sources of uncertainty considered in the analysis are modeling errors, observational data errors and fuzziness of the water quality standard. The difference between observed data or transformation thereof and corresponding model response is assumed to follow first-order Markov process, a specific case of which is statistically independent Gaussian errors. The BMCML method starts with sampling parameter sets from prior probability distributions of the model parameters and uses Bayes theorem and the maximum likelihood technique to estimate the triplicate (variance of residual errors, bias and autocorrelation coefficient of total errors) for each parameter set and the corresponding likelihood value. By approximating integration over the entire parameter space discretely, analytical expressions are derived for the cumulative probability distributions of model outputs and probability of violating water quality standards. The solution of the TMDL problem and related margin of safety (MOS) is then framed in the context of the developed Bayesian framework. Three example applications of varying complexities are utilized to demonstrate the versatility of the Bayesian methodology for water quality management. The BMCML methodology is validated using a hypothetical lake-phosphorus model and familiar statistical benchmarks. It is shown that the risk-based framework can estimate the reliability of an arbitrarily selected MOS as demonstrated in the Fork Creek bacteria and Shunganunga Creek dissolved oxygen TMDL case-studies. It is also shown that neglecting covariation among model parameters (i.e., by sampling parameter values from their posterior marginal distributions) influences the estimation of probability of exceedance and could potentially lead to the overestimation of the MOS at low risk levels. (C) 2014 American Society of Civil Engineers.
C1 [Hantush, Mohamed M.] US EPA, Land Remediat & Pollut Control Div, Natl Risk Management Res Lab, ORD, Cincinnati, OH 45268 USA.
[Chaudhary, Abhishek] ETH, Inst Environm Engn, CH-8093 Zurich, Switzerland.
[Chaudhary, Abhishek] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
RP Hantush, MM (reprint author), US EPA, Land Remediat & Pollut Control Div, Natl Risk Management Res Lab, ORD, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM hantush.mohamed@epa.gov
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-C-11-006]; Pegasus Technical Services, Inc.
FX The U.S. Environmental Protection Agency through its Office of Research
and Development partially funded and collaborated in the research
described here under contract (EP-C-11-006) with Pegasus Technical
Services, Inc. It has not been subject to the Agency review and
therefore does not necessarily reflect the views of the Agency, and no
official endorsement should be inferred.
NR 33
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U1 4
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PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
EI 1943-5584
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD SEP
PY 2014
VL 19
IS 9
AR 04014015
DI 10.1061/(ASCE)HE.1943-5584.0000900
PG 14
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AP7AC
UT WOS:000342228800008
ER
PT J
AU Amann, A
Costello, B
Miekisch, W
Schubert, J
Buszewski, B
Pleil, J
Ratcliffe, N
Risby, T
AF Amann, Anton
Costello, Ben de Lacy
Miekisch, Wolfram
Schubert, Jochen
Buszewski, Boguslaw
Pleil, Joachim
Ratcliffe, Norman
Risby, Terence
TI The human volatilome: volatile organic compounds (VOCs) in exhaled
breath, skin emanations, urine, feces and saliva
SO JOURNAL OF BREATH RESEARCH
LA English
DT Review
DE volatile organic compounds (VOCs); breath tests; skin emanations
ID CHROMATOGRAPHY-MASS-SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; ION
MOBILITY SPECTROMETRY; CRITICALLY-ILL PATIENTS; AUTOMATED HEADSPACE
CONCENTRATION; MECHANICALLY VENTILATED PATIENTS; ACUTE ALCOHOLIC
INTOXICATION; MEDIATED LIPID-PEROXIDATION; ACUTE MYOCARDIAL-INFARCTION;
MOSQUITO AEDES-AEGYPTI
AB Breath analysis is a young field of research with its roots in antiquity. Antoine Lavoisier discovered carbon dioxide in exhaled breath during the period 1777-1783, Wilhelm (Vilem) Petters discovered acetone in breath in 1857 and Johannes Muller reported the first quantitative measurements of acetone in 1898. A recent review reported 1765 volatile compounds appearing in exhaled breath, skin emanations, urine, saliva, human breast milk, blood and feces. For a large number of compounds, real-time analysis of exhaled breath or skin emanations has been performed, e.g., during exertion of effort on a stationary bicycle or during sleep. Volatile compounds in exhaled breath, which record historical exposure, are called the 'exposome'. Changes in biogenic volatile organic compound concentrations can be used to mirror metabolic or (patho)physiological processes in the whole body or blood concentrations of drugs (e.g. propofol) in clinical settings-even during artificial ventilation or during surgery. Also compounds released by bacterial strains like Pseudomonas aeruginosa or Streptococcus pneumonia could be very interesting. Methyl methacrylate (CAS 80-62-6), for example, was observed in the headspace of Streptococcus pneumonia in concentrations up to 1420 ppb. Fecal volatiles have been implicated in differentiating certain infectious bowel diseases such as Clostridium difficile, Campylobacter, Salmonella and Cholera. They have also been used to differentiate other non-infectious conditions such as irritable bowel syndrome and inflammatory bowel disease. In addition, alterations in urine volatiles have been used to detect urinary tract infections, bladder, prostate and other cancers. Peroxidation of lipids and other biomolecules by reactive oxygen species produce volatile compounds like ethane and 1-pentane. Noninvasive detection and therapeutic monitoring of oxidative stress would be highly desirable in autoimmunological, neurological, inflammatory diseases and cancer, but also during surgery and in intensive care units. The investigation of cell cultures opens up new possibilities for elucidation of the biochemical background of volatile compounds. In future studies, combined investigations of a particular compound with regard to human matrices such as breath, urine, saliva and cell culture investigations will lead to novel scientific progress in the field.
C1 [Amann, Anton] Med Univ Innsbruck, Univ Clin Anesthesia & Intens Care, A-6020 Innsbruck, Austria.
[Amann, Anton] Univ Innsbruck, Breath Res Inst, A-6850 Dornbirn, Austria.
[Costello, Ben de Lacy; Ratcliffe, Norman] Univ W England, Inst Biosensor Technol, Bristol BS16 1QY, Avon, England.
[Miekisch, Wolfram; Schubert, Jochen] Univ Rostock, Dept Anaesthesiol & Intens Care, D-18057 Rostock, Germany.
[Buszewski, Boguslaw] Nicholas Copernicus Univ, Fac Chem, Dept Environm Chem & Bioanalyt, PL-87100 Torun, Poland.
[Pleil, Joachim] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Risby, Terence] Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
RP Amann, A (reprint author), Med Univ Innsbruck, Univ Clin Anesthesia & Intens Care, Anichstr 35, A-6020 Innsbruck, Austria.
RI Buszewski, Boguslaw/A-3187-2009; Schubert, Jochen/F-4788-2016
OI Schubert, Jochen/0000-0002-0956-9506
FU Oncotyrol-project [2.1.1]; Austrian Federal Ministry for Transport,
Innovation, and Technology (BMVIT/BMWA) [836308]; Austrian Agency for
International Cooperation in Education and Research (OeAD-GmbH) [SPA
04/158-FEM_PERS]; Scientific and Technological Cooperation
(Wissenschaftlich-Technische Zusammenarbeit-WTZ) [PL 01/2012];
Vorarlberg (Austria); Competence Centre Oncotyrol
FX AA gratefully appreciates funding from the Oncotyrol-project 2.1.1. The
Competence Centre Oncotyrol is funded within the scope of the
COMET-Competence Centers for Excellent Technologies through BMVIT,
BMWFJ, through the province of Salzburg and the Tiroler
Zukunftsstiftung/Standortagentur Tirol. The COMET Program is conducted
by the Austrian Research Promotion Agency (FFG). AA appreciates funding
from the Austrian Federal Ministry for Transport, Innovation, and
Technology (BMVIT/BMWA, project 836308, KIRAS) and from the Austrian
Agency for International Cooperation in Education and Research
(OeAD-GmbH, project SPA 04/158-FEM_PERS). AA and BB appreciate funding
by the Scientific and Technological Cooperation
(Wissenschaftlich-Technische Zusammenarbeit-WTZ) between Austria and
Poland (project no PL 01/2012). AA thanks the government of Vorarlberg
(Austria) for its generous support. The contribution provided by JP has
been reviewed by US EPA and approved for publication.
NR 306
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PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1752-7155
EI 1752-7163
J9 J BREATH RES
JI J. Breath Res.
PD SEP
PY 2014
VL 8
IS 3
SI SI
AR 034001
DI 10.1088/1752-7155/8/3/034001
PG 17
WC Biochemical Research Methods; Respiratory System
SC Biochemistry & Molecular Biology; Respiratory System
GA AP0SO
UT WOS:000341774500002
PM 24946087
ER
PT J
AU Pleil, JD
Stiegel, MA
Fent, KW
AF Pleil, Joachim D.
Stiegel, Matthew A.
Fent, Kenneth W.
TI Exploratory breath analyses for assessing toxic dermal exposures of
firefighters during suppression of structural burns
SO JOURNAL OF BREATH RESEARCH
LA English
DT Article
DE adverse outcome pathway; exposome; firefighter; JP-8 jet fuel; PAHs;
benzene; heatmap
ID VOLATILE ORGANIC-COMPOUNDS; EXHALED BREATH; BIOMARKERS; SCIENCE;
EXHAUST; RISK
AB Firefighters wear fireproof clothing and self-contained breathing apparatus (SCBA) during rescue and fire suppression activities to protect against acute effects from heat and toxic chemicals. Fire services are also concerned about long-term health outcomes from chemical exposures over a working lifetime, in particular about low-level exposures that might serve as initiating events for adverse outcome pathways (AOP) leading to cancer. As part of a larger US National Institute for Occupational Safety and Health (NIOSH) study of dermal exposure protection from safety gear used by the City of Chicago firefighters, we collected pre- and post-fire fighting breath samples and analyzed for single-ring and polycyclic aromatic hydrocarbons as bioindicators of occupational exposure to gas-phase toxicants. Under the assumption that SCBA protects completely against inhalation exposures, any changes in the exhaled profile of combustion products were attributed to dermal exposures from gas and particle penetration through the protective clothing. Two separate rounds of firefighting activity were performed each with 15 firefighters per round. Exhaled breath samples were collected onto adsorbent tubes and analyzed with gas-chromatography-mass spectrometry (GC-MS) with a targeted approach using selective ion monitoring. We found that single ring aromatics and some PAHs were statistically elevated in post-firefighting samples of some individuals, suggesting that fire protective gear may allow for dermal exposures to airborne contaminants. However, in comparison to a previous occupational study of Air Force maintenance personnel where similar compounds were measured, these exposures are much lower suggesting that firefighters' gear is very effective. This study suggests that exhaled breath sampling and analysis for specific targeted compounds is a suitable method for assessing systemic dermal exposure in a simple and non-invasive manner.
C1 [Pleil, Joachim D.] US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA.
[Stiegel, Matthew A.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Fent, Kenneth W.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA.
RP Pleil, JD (reprint author), US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA.
EM pleil.joachim@epa.gov
FU NIOSH
FX The authors are thankful for the volunteer subjects from the Chicago
Fire Department. This research has been subjected to EPA review and
approved for publication. This study was internally funded by NIOSH and
approved by the NIOSH Human Subjects Review Board. The findings and
conclusions in this paper are those of the authors and do not
necessarily represent the views of NIOSH.
NR 41
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U1 3
U2 19
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1752-7155
EI 1752-7163
J9 J BREATH RES
JI J. Breath Res.
PD SEP
PY 2014
VL 8
IS 3
SI SI
AR 037107
DI 10.1088/1752-7155/8/3/037107
PG 9
WC Biochemical Research Methods; Respiratory System
SC Biochemistry & Molecular Biology; Respiratory System
GA AP0SO
UT WOS:000341774500012
PM 25190461
ER
PT J
AU Walker, MJ
AF Walker, Michael J.
TI Worth the Effort? NIMBY Public Comments Offer Little Value Added
SO PUBLIC ADMINISTRATION REVIEW
LA English
DT Editorial Material
C1 US EPA, Natl Enforcement Training Inst, Washington, DC 20460 USA.
RP Walker, MJ (reprint author), US EPA, Natl Enforcement Training Inst, Washington, DC 20460 USA.
EM walker.mike@epa.gov
NR 0
TC 0
Z9 0
U1 4
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0033-3352
EI 1540-6210
J9 PUBLIC ADMIN REV
JI Public Adm. Rev.
PD SEP-OCT
PY 2014
VL 74
IS 5
BP 629
EP 629
DI 10.1111/puar.12262
PG 1
WC Public Administration
SC Public Administration
GA AP0AJ
UT WOS:000341722400014
ER
PT J
AU Phelan, J
Belyazid, S
Kurz, D
Guthrie, S
Cajka, J
Sverdrup, H
Waite, R
AF Phelan, Jennifer
Belyazid, Salim
Kurz, Daniel
Guthrie, Scott
Cajka, James
Sverdrup, Harald
Waite, Randall
TI Estimation of Soil Base Cation Weathering Rates with the PROFILE Model
to Determine Critical Loads of Acidity for Forested Ecosystems in
Pennsylvania, USA: Pilot Application of a Potential National Methodology
SO WATER AIR AND SOIL POLLUTION
LA English
DT Article
DE Base cation; Weathering; Critical acid load; Nitrogen; Sulfur; Forest
ID NORTHEASTERN UNITED-STATES; FINE-ROOT DYNAMICS; NITROGEN DEPOSITION; RED
SPRUCE; UNCERTAINTY; EXCEEDANCES; CHEMISTRY; STRESS; HEALTH; CANADA
AB Base cation weathering (BCw) rate is one of the most influential yet difficult to estimate parameters in the calculation of critical acid loads of nitrogen (N) and sulfur (S) deposition for terrestrial systems. Only the clay correlation-substrate method, a simple empirical model, has been used for estimating BCw rates for forest ecosystems in the conterminous USA and may not be suitable for application at all sites without calibration or revision. An alternate model, PROFILE, may offer an improved method to estimate BCw rates. It is a transferable, process-based model that simulates the weathering rates of groups of minerals. The objective of this study was to evaluate PROFILE using national datasets as a method to estimate BCw rates for forests in the USA, focusing on Pennsylvania (PA) as the first test state. The model paired with national datasets was successfully applied at 51 forested sites across PA. Weathering rates ranged from 119 to 9,245 eq ha(-1) year(-1) and were consistent with soil properties and regional geology. Comparisons of terrestrial critical acid loads with 2002 N and S deposition showed critical load exceedances at 53 % of the sites. This trial evaluation of PROFILE paired with national datasets in PA establishes that there are sufficient data to support the estimation of BCw rates and determination of critical acid loads for forests in the USA. However, the paired method should be applied in other locations to further evaluate the performance of the model in different regions of the country.
C1 [Phelan, Jennifer; Guthrie, Scott; Cajka, James] RTI Int, Res Triangle Pk, NC 27709 USA.
[Belyazid, Salim] Belyazid Consulting & Commun AB, S-21128 Malmo, Sweden.
[Kurz, Daniel] EKG Geosci, CH-3011 Bern, Switzerland.
[Sverdrup, Harald] Lund Univ, S-22100 Lund, Sweden.
[Waite, Randall] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Phelan, J (reprint author), RTI Int, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
EM jenphelan@rti.org
FU U.S. Environmental Protection Agency (EPA)
FX Funding for this work was provided by the U.S. Environmental Protection
Agency (EPA). Any opinions, findings, conclusions, or recommendations
are those of the authors and do not necessarily reflect the views of the
EPA. The authors wish to thank William Cannon and David Smith for their
assistance with the USGS Landscapes Project soil mineralogy dataset,
Mike Wilson for his assistance with the USDA-NRCS SSURGO soil database,
and Jason Lynch and Tara Greaver for their support and constructive
review of the manuscript.
NR 68
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U1 1
U2 17
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0049-6979
EI 1573-2932
J9 WATER AIR SOIL POLL
JI Water Air Soil Pollut.
PD SEP
PY 2014
VL 225
IS 9
AR 2109
DI 10.1007/s11270-014-2109-4
PG 19
WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water
Resources
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences;
Water Resources
GA AP1NG
UT WOS:000341836700029
ER
PT J
AU Yurista, PM
Yule, DL
Balge, M
VanAlstine, JD
Thompson, JA
Gamble, AE
Hrabik, TR
Kelly, JR
Stockwell, JD
Vinson, MR
AF Yurista, Peder M.
Yule, Daniel L.
Balge, Matt
VanAlstine, Jon D.
Thompson, Jo A.
Gamble, Allison E.
Hrabik, Tom R.
Kelly, John R.
Stockwell, Jason D.
Vinson, Mark R.
TI A new look at the Lake Superior biomass size spectrum
SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
LA English
DT Article
ID OPTICAL PLANKTON COUNTER; DIEL VERTICAL MIGRATION; CISCO
COREGONUS-ARTEDI; GREAT-LAKES; FOOD-WEB; RAINBOW-SMELT; AQUATIC
ECOSYSTEMS; ECOLOGICAL CHANGE; ACOUSTIC SURVEYS; FRESH-WATER
AB We synthesized data from multiple sampling programs and years to describe the Lake Superior pelagic biomass size structure. Data consisted of Coulter counts for phytoplankton, optical plankton counts for zooplankton, and acoustic surveys for pelagic prey fish. The size spectrum was stable across two time periods separated by 5 years. The primary scaling or overall slope of the normalized biomass size spectra for the combined years was -1.113, consistent with a previous estimate for Lake Superior (-1.10). Periodic dome structures within the overall biomass size structure were fit to polynomial regressions based on the observed sub-domes within the classical taxonomic positions (algae, zooplankton, and fish). This interpretation of periodic dome delineation was aligned more closely with predator-prey size relationships that exist within the zooplankton (herbivorous, predacious) and fish (planktivorous, piscivorous) taxonomic positions. Domes were spaced approximately every 3.78 log10 units along the axis and with a decreasing peak magnitude of -4.1 log10 units. The relative position of the algal and herbivorous zooplankton domes predicted well the subsequent biomass domes for larger predatory zooplankton and planktivorous prey fish.
C1 [Yurista, Peder M.; VanAlstine, Jon D.; Thompson, Jo A.; Kelly, John R.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
[Yule, Daniel L.; Stockwell, Jason D.; Vinson, Mark R.] US Geol Survey, Great Lakes Sci Ctr, Lake Super Biol Stn, Ashland, WI 54806 USA.
[Balge, Matt; Gamble, Allison E.; Hrabik, Tom R.] Univ Minnesota, Dept Biol, Duluth, MN 55812 USA.
RP Yurista, PM (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM yurista.peder@epa.gov
FU US Environmental Protection Agency; US Geological Survey; Lake Superior
LaMP Technical Committee; US EPA Great Lakes National Program Office
FX We thank M. E. Sierszen for his comments and discussion that helped to
improve this paper and two reviewers who helped in shaping clarity and
presentation. Tyler Sikora helped with data analysis of pelagic fish
domes. This work was funded by the US Environmental Protection Agency,
US Geological Survey, and Lake Superior LaMP Technical Committee. Ship
time on the R/V Lake Guardian was supported by the US EPA Great Lakes
National Program Office. Development of statistical designs used in 2006
and 2011 were with the assistance of Tony Olsen (Western Ecology
Division US EPA ORD) and Matt Starry with related GIS work. Any use of
trade, product, or firm names is for descriptive purposes only and does
not imply endorsement by the US Government. The views expressed in this
article are those of the authors and do not necessarily reflect the
views or policies of the USEPA. This article is contribution 1851 of the
US Geological Survey Great Lakes Science Center.
NR 64
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U1 4
U2 24
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0706-652X
EI 1205-7533
J9 CAN J FISH AQUAT SCI
JI Can. J. Fish. Aquat. Sci.
PD SEP
PY 2014
VL 71
IS 9
BP 1324
EP 1333
DI 10.1139/cjfas-2013-0596
PG 10
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA AO7FP
UT WOS:000341518100005
ER
PT J
AU Gawande, MB
Rathi, AK
Tucek, J
Safarova, K
Bundaleski, N
Teodoro, OMND
Kvitek, L
Varma, RS
Zboril, R
AF Gawande, Manoj B.
Rathi, Anuj K.
Tucek, Jiri
Safarova, Klara
Bundaleski, Nenad
Teodoro, Orlando M. N. D.
Kvitek, Libor
Varma, Rajender S.
Zboril, Radek
TI Magnetic gold nanocatalyst (nanocat-Fe-Au): catalytic applications for
the oxidative esterification and hydrogen transfer reactions
SO GREEN CHEMISTRY
LA English
DT Article
ID MULTICOMPONENT REACTIONS; SELECTIVE OXIDATION; CARBONYL-COMPOUNDS;
COATED MAGHEMITE; AQUEOUS-MEDIA; SULFONIC-ACID; SOLVENT-FREE;
NANOPARTICLES; CHEMISTRY; OXIDE
AB An efficient and sustainable protocol is described for the oxidative esterification of aldehydes and the reduction of aromatic nitro compounds that uses a magnetically separable and reusable maghemite-supported gold nanocatalyst (nanocat-Fe-Au) under mild conditions. The complex chemical, morphological, structural and size analyses, including e.g. XPS, HRTEM, Mossbauer spectroscopy and HRTEM, revealed that the hybrid material is composed of a well-defined stoichiometric maghemite support (20-30 nm) decorated with ultrasmall (5-6 nm) gold nanoparticles. The hybrid catalytic system containing 4 wt% of nanogold has been generated using simple impregnation methods in aqueous medium from readily available starting materials and was recycled five times without any significant loss in catalytic activity; high yields, 40-95% and 83-94% for oxidative esterification and reduction reactions, respectively, were obtained.
C1 [Gawande, Manoj B.; Rathi, Anuj K.; Tucek, Jiri; Safarova, Klara; Kvitek, Libor; Zboril, Radek] Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic.
[Bundaleski, Nenad; Teodoro, Orlando M. N. D.] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Phys, Ctr Phys & Technol Res CeFITec, P-2829516 Caparica, Portugal.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Gawande, MB (reprint author), Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Slechtitelu 11, Olomouc 78371, Czech Republic.
EM manoj.gavande@upol.cz; Varma.Rajender@epa.gov; radek.zboril@upol.cz
RI Zboril, Radek/F-5153-2015;
OI Teodoro, Orlando/0000-0002-3424-2847; Bundaleski,
Nenad/0000-0002-5958-2282; Zboril, Radek/0000-0002-3147-2196
FU Operational Program Research and Development for Innovations - European
Regional Development Fund [CZ.1.05/2.1.00/03.0058]; Operational Program
Education for competitiveness - European Social Fund of the Ministry of
Education, Youth and Sports of the Czech Republic
[CZ.1.07/2.3.00/30.0041]; Technology Agency of the Czech Republic
"Competence Centres" [TE01010218]; Portuguese Research Grant
[Pest-OE/FIS/UI0068/2011]
FX The authors gratefully acknowledge the support by the Operational
Program Research and Development for Innovations - European Regional
Development Fund (project CZ.1.05/2.1.00/03.0058), by the Operational
Program Education for competitiveness - European Social Fund (project
CZ.1.07/2.3.00/30.0041) of the Ministry of Education, Youth and Sports
of the Czech Republic, by the Technology Agency of the Czech Republic
"Competence Centres" (project TE01010218) and by the Portuguese Research
Grant Pest-OE/FIS/UI0068/2011.
NR 48
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Z9 24
U1 3
U2 81
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PD SEP
PY 2014
VL 16
IS 9
BP 4137
EP 4143
DI 10.1039/c4gc00774c
PG 7
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA AO4BW
UT WOS:000341282200014
ER
PT J
AU Li, T
Li, X
AF Li, Tao
Li, Xuan
TI Comprehensive mass analysis for chemical processes, a case study on
L-Dopa manufacture
SO GREEN CHEMISTRY
LA English
DT Article
ID TREGOE DECISION-ANALYSIS; RESEARCH-AND-DEVELOPMENT; GREEN CHEMISTRY;
PHARMACEUTICAL-INDUSTRY; METHYL-BROMIDE; ROUTE; METRICS; TOOL;
PERSPECTIVE; SUSTAINABILITY
AB To evaluate the "greenness" of chemical processes in route selection and process development, we propose a comprehensive mass analysis to inform the stakeholders from different fields. This is carried out by characterizing the mass intensity for each contributing chemical or waste component with a new algorithm. The analysis is demonstrated with the evaluation of commercial processes for L-Dopa. The plan-wide impacts on inputs are estimated for design features such as the choice of starting material, the use of one-pot synthesis for multiple reactions, recycling of the wrong enantiomer, methods for intermediate isolation, and volumetric productivity. The waste effluent profile is generated to project waste management needs. It has been found that the current biocatalytic process (Ajinomoto) has the best process efficiency and minimal waste treatment needs. The mass efficiency has been improved by at least 6.5 fold through biocatalyst optimization, and reaction intensification employing the crystallization-induced equilibrium shift.
C1 [Li, Tao; Li, Xuan] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Li, T (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26 W Martin L King Dr, Cincinnati, OH 45268 USA.
EM li.tao@epa.gov
NR 51
TC 1
Z9 1
U1 0
U2 9
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PD SEP
PY 2014
VL 16
IS 9
BP 4241
EP 4256
DI 10.1039/c4gc00565a
PG 16
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA AO4BW
UT WOS:000341282200026
ER
PT J
AU Baig, RBN
Nadagouda, MN
Varma, RS
AF Baig, R. B. Nasir
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI Carbon-coated magnetic palladium: applications in partial oxidation of
alcohols and coupling reactions
SO GREEN CHEMISTRY
LA English
DT Article
ID CATALYTIC C-C; AEROBIC OXIDATION; HETEROGENEOUS CATALYSIS; EFFICIENT
CATALYST; ORGANIC-SYNTHESIS; MOLECULAR-OXYGEN; AMINO-ACIDS; PD CATALYST;
NANOPARTICLES; COPPER
AB A carbon-coated magnetic Pd catalyst has been synthesized via in situ generation of nanoferrites and incorporation of carbon from renewable cellulose via calcination; the catalyst can be used for oxidation of alcohols, amination reaction and arylation of aryl halides (cross-coupling reaction).
C1 [Baig, R. B. Nasir; Nadagouda, Mallikarjuna N.; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Baig, RBN (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM Varma.Rajender@epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory; U.S. Environmental Protection Agency
FX R. B. Nasir Baig was supported by the Postgraduate Research Program at
the National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 47
TC 23
Z9 23
U1 3
U2 31
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PD SEP
PY 2014
VL 16
IS 9
BP 4333
EP 4338
DI 10.1039/c4gc00748d
PG 6
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA AO4BW
UT WOS:000341282200035
ER
PT J
AU Baig, RBN
Varma, RS
AF Baig, R. B. Nasir
Varma, Rajender S.
TI Magnetic Carbon-Supported Palladium Nanoparticles: An Efficient and
Sustainable Catalyst for Hydrogenation Reactions
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Nano ferrites; Cellulose; Reduction; Allcenes; Nitro compounds; Magnetic
separation
ID GREEN CHEMISTRY
AB A magnetic carbon-supported Pd catalyst has been synthesized via in situ generation of nanoferrites and incorporation of carbon from renewable cellulose via calcination. The catalyst can be used for the hydrogenation of alkenes and reduction of aryl nitro compounds.
C1 [Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@.epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory
FX R. B. Nasir Baig was supported by the Postgraduate Research Program at
the National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 23
TC 23
Z9 23
U1 6
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD SEP
PY 2014
VL 2
IS 9
BP 2155
EP 2158
DI 10.1021/sc500341h
PG 4
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA AO3KW
UT WOS:000341229100009
ER
PT J
AU Yadav, JSS
Yan, S
More, TT
Tyagi, RD
Surampalli, RY
AF Yadav, J. S. S.
Yan, S.
More, T. T.
Tyagi, R. D.
Surampalli, R. Y.
TI Recovery of residual soluble protein by two-step precipitation process
with concomitant COD reduction from the yeast-cultivated cheese whey
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Fermentation; Whey protein; Thermal precipitation;
Carboxymethylcellulose; Recovery; COD
ID MOLECULAR-WEIGHT PHENOLICS; BETA-LACTOGLOBULIN; ALPHA-LACTALBUMIN;
MILK-PROTEINS; THERMAL-DENATURATION; SERUM-ALBUMIN; BY-PRODUCTS; SHEAR
RATE; BINDING; CARBOXYMETHYLCELLULOSE
AB The present study was conducted to recover the residual soluble protein after cultivation of yeast (K. marxianus) in cheese whey. Cheese whey continuous fermentation with cell recycle system was carried out at 40 A degrees C and pH 3.5. The yeast biomass was separated from the fermented broth by centrifugation and residual soluble protein from fermented whey supernatant was precipitated by heat treatment (at 100 A degrees C, pH 4.5 and 10 min incubation). The maximum soluble protein recovery up to 53 % was achieved at pH 4.5 with 54 % residual COD removal. However, gravity sedimentable precipitates were obtained at pH 3.5 with 47 % protein recovery. Therefore, the reactor (scale up) study was conducted at pH 3.5 with agitation, which resulted in 68 % of residual soluble protein recovery and simultaneously residual COD removal of 62 %. Further precipitation/coagulation of soluble protein was also evaluated using carboxymethylcellulose (CMC) and then two precipitation (thermal followed by CMC precipitation) processes were combined to increase the protein precipitation, which finally reached up to 81 % of total soluble protein recovery from the supernatant. This optimized process could be applied to recover the residual protein left after fermentation of cheese whey without centrifugation.
C1 [Yadav, J. S. S.; Yan, S.; More, T. T.; Tyagi, R. D.] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, 490 Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
RDCPJ379601-08]; Natural Sciences and Engineering Research Council of
Canada (Canada Research Chair)
FX Authors are sincerely thankful to Natural Sciences and Engineering
Research Council of Canada (Grant A4984, RDCPJ379601-08, and Canada
Research Chair) for their financial support.
NR 51
TC 2
Z9 2
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-7591
EI 1615-7605
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD SEP
PY 2014
VL 37
IS 9
BP 1825
EP 1837
DI 10.1007/s00449-014-1155-z
PG 13
WC Biotechnology & Applied Microbiology; Engineering, Chemical
SC Biotechnology & Applied Microbiology; Engineering
GA AO1SN
UT WOS:000341094500014
PM 24615516
ER
PT J
AU Bushel, PR
Wang, C
Gong, B
Thierry-Mieg, J
Thierry-Mieg, D
Xu, J
Fang, H
Kreil, DP
Megherbi, D
Li, J
Paules, RS
Shi, L
Auerbach, SS
Tong, W
AF Bushel, P. R.
Wang, C.
Gong, B.
Thierry-Mieg, J.
Thierry-Mieg, D.
Xu, J.
Fang, H.
Kreil, D. P.
Megherbi, D.
Li, J.
Paules, R. S.
Shi, L.
Auerbach, S. S.
Tong, W.
TI Bioinformatics Applications Reveal Gene Regulation Complexities in
Response to Toxicant Exposures.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Bushel, P. R.; Paules, R. S.; Auerbach, S. S.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Gong, B.; Xu, J.; Fang, H.; Shi, L.; Tong, W.] Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Wang, C.] Loma Linda Univ, Loma Linda, CA 92350 USA.
[Thierry-Mieg, J.; Thierry-Mieg, D.] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
[Kreil, D. P.] Boku Univ, Vienna, Austria.
[Kreil, D. P.] Univ Warwick, Coventry CV4 7AL, W Midlands, England.
[Megherbi, D.] Univ Massachusetts, Lowell, MA USA.
[Li, J.] Kelly Govt Solut, Durham, NC USA.
RI Gong, Binsheng/E-2306-2015
OI Gong, Binsheng/0000-0002-8724-5435
NR 0
TC 0
Z9 0
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA S51
BP S31
EP S31
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900060
ER
PT J
AU Divi, RL
Lindeman, TE
Shockley, ME
Keshava, C
Weston, A
Poirier, MC
AF Divi, R. L.
Lindeman, T. E.
Shockley, M. E.
Keshava, C.
Weston, A.
Poirier, M. C.
TI Correlation between CYP1A1 RNA Transcript, Protein Level, Enzyme
Activity, and DNA Adducts in Primary Normal Human Mammary Epithelial
Cells Exposed to Benzo[a]pyrene
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Divi, R. L.; Lindeman, T. E.; Shockley, M. E.; Poirier, M. C.] NCI, Bethesda, MD 20892 USA.
[Keshava, C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Weston, A.] NIOSH, Div Resp Dis Studies, CDC, Morgantown, WV 26505 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P68
BP S56
EP S56
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900159
ER
PT J
AU Gibbons, CF
Caldwell, JC
Chiu, WA
DeMarini, DM
Fritz, JM
AF Gibbons, C. F.
Caldwell, J. C.
Chiu, W. A.
DeMarini, D. M.
Fritz, J. M.
TI A Systematic Approach to Organizing Mechanistic Data for Risk Assessment
by Linking Endpoints with Informative Mechanistic Characteristics of
Carcinogenesis.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Gibbons, C. F.; Caldwell, J. C.; Chiu, W. A.; Fritz, J. M.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[DeMarini, D. M.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Washington, DC 20460 USA.
RI Fritz, Jason/K-1439-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P51
BP S52
EP S52
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900143
ER
PT J
AU Keshava, N
Woodall, G
Keshava, C
Reinhart, P
AF Keshava, N.
Woodall, G.
Keshava, C.
Reinhart, P.
TI Chemically-Induced Mouse Lung Tumors: Applications to Human Health
Assessments.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Keshava, N.; Woodall, G.; Keshava, C.; Reinhart, P.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RI Woodall, George/M-5658-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P52
BP S52
EP S52
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900144
ER
PT J
AU Kligerman, AD
Geter, DR
George, MH
Moore, TM
Wood, CE
DeAngelo, AB
AF Kligerman, A. D.
Geter, D. R.
George, M. H.
Moore, T. M.
Wood, C. E.
DeAngelo, A. B.
TI Induction of Aberrant Crypt Foci (ACF) in Rats By Haloacetic Acids
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Kligerman, A. D.; Geter, D. R.; George, M. H.; Moore, T. M.; Wood, C. E.; DeAngelo, A. B.] US EPA, Res Triangle Pk, NC 27711 USA.
[Geter, D. R.] Bayer Crop Sci LP, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P91
BP S61
EP S61
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900182
ER
PT J
AU Nath, RG
Sonawane, BR
Vulimiri, SV
Lin, YS
AF Nath, R. G.
Sonawane, B. R.
Vulimiri, S. V.
Lin, Y-S
TI Epigenetic Effects of Cadmium.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Nath, R. G.; Sonawane, B. R.; Vulimiri, S. V.; Lin, Y-S] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P81
BP S59
EP S59
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900172
ER
PT J
AU Schoeny, R
AF Schoeny, R.
TI Incorporating Biological, Chemical, and Toxicological Knowledge into
Predictive Models of Toxicity.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Schoeny, R.] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA S17
BP S23
EP S23
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900027
ER
PT J
AU Schoeny, RS
Thybaud, V
van Benthem, J
Delrue, N
Douglas, GR
Lorge, E
Lovell, DP
Singer, T
AF Schoeny, R. S.
Thybaud, V
van Benthem, J.
Delrue, N.
Douglas, G. R.
Lorge, E.
Lovell, D. P.
Singer, T.
TI Revision of OECD Guidelines for Genotoxicity Testing: Current Status and
Next Steps.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Schoeny, R. S.] US EPA, Washington, DC 20460 USA.
[Thybaud, V] Sanofi, Vitry Sur Seine, France.
[van Benthem, J.] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
[Delrue, N.] OECD, Paris, France.
[Douglas, G. R.; Singer, T.] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Lorge, E.] Servier Grp, Orleans, France.
[Lovell, D. P.] Univ London, London, England.
ENVIRON Int Corp, Little Rock, AR USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P50
BP S51
EP S51
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900142
ER
PT J
AU Sonawane, BR
Nath, RG
Makris, SL
AF Sonawane, B. R.
Nath, R. G.
Makris, S. L.
TI Epigenetic Effects of Di(2-ethylhexyl) Phthalate.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Sonawane, B. R.; Nath, R. G.; Makris, S. L.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P82
BP S59
EP S59
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900173
ER
PT J
AU Thomas, RS
AF Thomas, R. S.
TI Toxicogenomics and Dose-Response: Applications to Risk Assessment.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [Thomas, R. S.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 2
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA S41
BP S29
EP S29
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900050
ER
PT J
AU VanDuyn, NM
Franzosa, JA
Houck, KA
Ward, WO
Chorley, BN
Corton, JC
AF VanDuyn, N. M.
Franzosa, J. A.
Houck, K. A.
Ward, W. O.
Chorley, B. N.
Corton, J. C.
TI Building Predictive Gene Signatures through Simultaneous Assessment of
Transcription Factor Activation and Gene Expression.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
Environmental-Mutagenesis-and-Genomics-Society (EMGS)
CY SEP 13-17, 2014
CL Orlando, FL
SP Environm Mutagenesis & Genom Soc
C1 [VanDuyn, N. M.; Franzosa, J. A.; Houck, K. A.; Ward, W. O.; Chorley, B. N.; Corton, J. C.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD SEP
PY 2014
VL 55
SU 1
MA P41
BP S49
EP S49
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA AO2ST
UT WOS:000341176900133
ER
PT J
AU Winquist, A
Kirrane, E
Klein, M
Strickland, M
Darrow, LA
Sarnat, SE
Gass, K
Mulholland, J
Russell, A
Tolbert, P
AF Winquist, Andrea
Kirrane, Ellen
Klein, Mitch
Strickland, Matthew
Darrow, Lyndsey A.
Sarnat, Stefanie Ebelt
Gass, Katherine
Mulholland, James
Russell, Armistead
Tolbert, Paige
TI Joint Effects of Ambient Air Pollutants on Pediatric Asthma Emergency
Department Visits in Atlanta, 1998-2004
SO EPIDEMIOLOGY
LA English
DT Article
ID CUMULATIVE RISK-ASSESSMENT; SHORT-TERM ASSOCIATIONS; TIME-SERIES HEALTH;
SOURCE-APPORTIONMENT; GASEOUS-POLLUTANTS; MEASUREMENT ERROR; DAILY
MORTALITY; POLLUTION; QUALITY; MULTIPOLLUTANT
AB Background: Because ambient air pollution exposure occurs as mixtures, consideration of joint effects of multiple pollutants may advance our understanding of the health effects of air pollution.
Methods: We assessed the joint effect of air pollutants on pediatric asthma emergency department visits in Atlanta during 1998-2004. We selected combinations of pollutants that were representative of oxidant gases and secondary, traffic, power plant, and criteria pollutants, constructed using combinations of criteria pollutants and fine particulate matter (PM2.5) components. Joint effects were assessed using multipollutant Poisson generalized linear models controlling for time trends, meteorology, and daily nonasthma upper respiratory emergency department visit counts. Rate ratios (RRs) were calculated for the combined effect of an interquartile range increment in each pollutant's concentration.
Results: Increases in all of the selected pollutant combinations were associated with increases in warm-season pediatric asthma emergency department visits (eg, joint-effect RR = 1.13 [95% confidence interval = 1.06-1.21] for criteria pollutants, including ozone, carbon monoxide, nitrogen dioxide, sulfur dioxide, and PM2.5). Cold-season joint effects from models without nonlinear effects were generally weaker than warm-season effects. Joint-effect estimates from multipollutant models were often smaller than estimates based on single-pollutant models, due to control for confounding. Compared with models without interactions, joint-effect estimates from models including first-order pollutant interactions were largely similar. There was evidence of nonlinear cold-season effects.
Conclusions: Our analyses illustrate how consideration of joint effects can add to our understanding of health effects of multipollutant exposures and also illustrate some of the complexities involved in calculating and interpreting joint effects of multiple pollutants.
C1 [Winquist, Andrea; Klein, Mitch; Strickland, Matthew; Sarnat, Stefanie Ebelt; Tolbert, Paige] Emory Univ, Dept Environm Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Kirrane, Ellen] US EPA, Natl Ctr Environm Assessment, Durham, NC USA.
[Darrow, Lyndsey A.; Gass, Katherine] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Mulholland, James; Russell, Armistead] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
RP Winquist, A (reprint author), 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM awinqui@emory.edu
RI Tolbert, Paige/A-5676-2015
FU US Environmental Protection Agency (USEPA) [EP-12-H-000093]; National
Institutes of Health (NIH) [K01ES019877]; USEPA [R834799, STAR
R829213-01]; NIH [R01ES011294]; Electric Power Research Institute
[EP-P27723/C13172]
FX This publication was made possible by US Environmental Protection Agency
(USEPA), contract EP-12-H-000093, National Institutes of Health (NIH)
grant K01ES019877, and USEPA grant R834799. The views expressed in this
manuscript are those of the authors and do not necessarily represent the
views or policies of the USEPA. Further, USEPA does not endorse the
purchase of any commercial products or services mentioned in the
publication. Support for the original emergency department study was
provided by grants from NIH (R01ES011294), USEPA (STAR R829213-01), and
the Electric Power Research Institute (EP-P27723/C13172).
NR 40
TC 15
Z9 15
U1 4
U2 37
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2014
VL 25
IS 5
BP 666
EP 673
DI 10.1097/EDE.0000000000000146
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AN6RA
UT WOS:000340722600006
PM 25045931
ER
PT J
AU Ferreira, WR
Ligeiro, R
Macedo, DR
Hughes, RM
Kaufmann, PR
Oliveira, LG
Callisto, M
AF Ferreira, Wander R.
Ligeiro, Raphael
Macedo, Diego R.
Hughes, Robert M.
Kaufmann, Philip R.
Oliveira, Leandro G.
Callisto, Marcos
TI Importance of environmental factors for the richness and distribution of
benthic macroinvertebrates in tropical headwater streams
SO FRESHWATER SCIENCE
LA English
DT Article
DE EPT assemblages; physical habitat; hydromorphology; stream conservation;
macroinvertebrate bioindicators; Cerrado headwater streams
ID BIOTIC INTEGRITY; MULTIMETRIC INDEX; PHYSICAL HABITAT; BRAZILIAN
CERRADO; EUROPEAN STREAMS; WADEABLE STREAMS; LAND-USE; FISH; RIVER;
SCALE
AB An understanding of the interactions among local environmental factors (e.g., physical habitat and water quality) and aquatic assemblages is essential to conserve biodiversity in tropical and subtropical headwater streams. We evaluated the relative importance of multiple physical and chemical habitat variables that influence the richness of Ephemeroptera, Plecoptera, and Trichoptera (EPT) assemblages in wadeable Brazilian Cerrado (savanna) streams. We sampled macroinvertebrate assemblages and quantified physical and chemical habitat in 79 randomly selected sites in 2 Cerrado basins in southeastern Brazil. The environmental variables selected by multiple regression models (MLRs) via corrected Akaike Information Criteria (AICc) contributed significantly to variation in EPT taxon richness. The variance explained by physical-habitat variables was slightly greater in the Upper Sao Francisco Basin (adjusted R-2 = 0.53) than in the Upper Araguari Basin (adjusted R-2 = 0.46), and both were greater than the variance explained by a combined basin model (adjusted R-2 = 0.39). Physical-habitat variables were more important than water-quality variables in structuring EPT genera in streams with catchments dominated by agriculture or pasture land uses. Regional models can be improved by incorporating basin-specific information to refine biological assessments and to provide better understanding of the interactions that maintain biodiversity in stream networks.
C1 [Ferreira, Wander R.; Ligeiro, Raphael; Macedo, Diego R.; Callisto, Marcos] Univ Fed Minas Gerais, Lab Ecol Bentos, Dept Biol Geral, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil.
[Macedo, Diego R.] Inst Brasileiro Geog & Estat, BR-30310150 Belo Horizonte, MG, Brazil.
[Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97333 USA.
[Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA.
[Kaufmann, Philip R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Oliveira, Leandro G.] Univ Fed Goias, Dept Ecol, Inst Ciencias Biol, BR-74001970 Goiania, Go, Brazil.
RP Ferreira, WR (reprint author), Univ Fed Minas Gerais, Lab Ecol Bentos, Dept Biol Geral, Inst Ciencias Biol, Av Antonio Carlos 6627,CP 486, BR-31270901 Belo Horizonte, MG, Brazil.
EM ferreirawr@gmail.com; ligeirobio@gmail.com; rodriguesmacedo@gmail.com;
hughes.bob@amnisopes.com; kaufmann.phil@epamail.epa.gov; lego@ufg.br;
callistom@ufmg.br
RI Macedo, Diego/G-2506-2015; Ligeiro, Raphael/K-7791-2015; Callisto,
Marcos/O-4930-2015
OI Macedo, Diego/0000-0002-1178-4969; Ligeiro, Raphael/0000-0001-9717-5461;
Callisto, Marcos/0000-0003-2341-4700
FU Peixe-Vivo Program of Companhia Energetica de Minas Gerais; Pesquisa &
Desenvolvimento/Agencia Nacional de Energia Eletrica/Companhia
Energetica de Minas Gerais-PD [ANEEL/CEMIG GT-487]; Coordenacao de
Aperfeicoamento de Pessoal de Nivel Superior; Conselho Nacional de
Desenvolvimento Cientifico e Tecnologico; Fundacao de Amparo a Pesquisa
do Estado de Minas Gerais; Fulbright-Brasil; Conselho Nacional de
Desenvolvimento Cientifico e Tecnologico (CNPq) [471385/211-5,
302960/2011-2]; Fundacao de Amparo da Pesquisa do Estado de Minas Gerais
(FAPEMIG) [PPM-00077/13]
FX We thank the Peixe-Vivo Program of Companhia Energetica de Minas Gerais,
Pesquisa & Desenvolvimento/Agencia Nacional de Energia
Eletrica/Companhia Energetica de Minas Gerais-P&D ANEEL/CEMIG GT-487,
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Conselho
Nacional de Desenvolvimento Cientifico e Tecnologico, Fundacao de Amparo
a Pesquisa do Estado de Minas Gerais, and Fulbright-Brasil for financial
support. MC received a research grant and a research fellowship from the
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq no.
471385/211-5 and 302960/2011-2) and research grant from the Fundacao de
Amparo da Pesquisa do Estado de Minas Gerais (FAPEMIG PPM-00077/13).
Tony Olsen, Marc Weber, and Phil Larsen of the Corvallis US
Environmental Protection Agency Laboratory (Oregon, USA) kindly assisted
in developing spatial sampling designs and selecting wadeable stream
sample sites in our Brazilian basins. We thank Juliana Franca, Deborah
Silva, and Ana Paula Eller for water-quality analyses; Carlos Bernardo
Mascarenhas Alves for logistical support; colleagues from the Federal
University of Minas Gerais Benthic Ecology Laboratory, Federal Center of
Technological Education of Minas Gerais, Federal University of Lavras,
and Pontifical Catholic University of Minas Gerais for help with field
collections; and researchers at the US EPA Western Ecology Division,
Corvallis, Oregon, for discussions during an October 2011 workshop. Our
manuscript was improved based on reviews by Bob Ozretich and Michael
Griffith of the US EPA and 2 anonymous referees. This manuscript has
been subjected to review by the US EPA National Health and Environmental
Effects Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 71
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U1 9
U2 92
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 2161-9549
EI 2161-9565
J9 FRESHW SCI
JI Freshw. Sci.
PD SEP
PY 2014
VL 33
IS 3
BP 860
EP 871
DI 10.1086/676951
PG 12
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AN4TF
UT WOS:000340580700016
ER
PT J
AU Snyder, E
Drake, J
Cardarelli, J
Hall, K
Szabo, J
Demmer, R
Lindberg, M
Riggs, K
James, R
AF Snyder, Emily
Drake, John
Cardarelli, John
Hall, Kathy
Szabo, Jeff
Demmer, Rick
Lindberg, Michael
Riggs, Karen
James, Ryan
TI ASSESSMENT OF SELF-HELP METHODS TO REDUCE POTENTIAL EXPOSURE TO
RADIOLOGICAL CONTAMINATION AFTER A LARGE-SCALE RADIOLOGICAL RELEASE
SO HEALTH PHYSICS
LA English
DT Article
DE Cs-137; accidents, nuclear; cesium; exposure, radiation
AB After the release of radioactive materials from a large radiological dispersal device (e.g., dirty bomb), improvised nuclear detonation, or nuclear power plant accident, up to hundreds of square miles may be contaminated. A portion of this area will be evacuated; however, people living in the portion that is not evacuated yet is still contaminated with low-levels of radioactive contamination will be asking for ways they can reduce their exposure. Whether cleaning activities can significantly reduce exposure is not fully understood. In this effort, the ability of cleaning activities to remove cesium (Cs-137) was studied. The removal efficacy of cleaning with a commercial product, Simple Green (R), was compared to cleaning with water for hard surfaces typically seen in residences. The removal efficacy of laundering fabric material surfaces was also determined for a range of conditions (e.g., fabric material type, wash temperature). During these studies, assessments of the implications of these activities (e.g., cross-contamination, resulting waste streams) were also completed. Simple Green (R) and water were effective for removing Cs-137 from plastic laminate and vinyl flooring (93.4-96.8%) but were not effective for removing Cs-137 from painted wallboard and wood (7.3-68.1%). It was also determined that there was no significant difference between the two cleaners on all of the surfaces, except plastic laminate, for which Simple Green (R) was slightly more effective. Laundering was effective for removing Cs-137 contamination from polyester and cotton swatches and cotton comforters (up to 96.8% in the single swatch testing).
C1 [Snyder, Emily] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
[Drake, John; Hall, Kathy; Szabo, Jeff] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
[Cardarelli, John] US EPA, Off Solid Waste, Erlanger, KY 41018 USA.
[Cardarelli, John] Emergency Response Off Emergency Managements Cons, Erlanger, KY 41018 USA.
[Demmer, Rick] Idaho Natl Lab, Idaho Falls, ID 83415 USA.
[Lindberg, Michael] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Riggs, Karen; James, Ryan] Battelle Mem Inst, Columbus, OH 43201 USA.
RP Snyder, E (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM snyder.emily@epa.gov
FU United States Environmental Protection Agency through its Office of
Research and Development [EP-C-10-001]
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here
(through Battelle contract No. EP-C-10-001). It has been subjected to
Agency's administrative review and approved for publication. The views
expressed in this manuscript are those of the authors and do not
necessarily reflect the views or policies of the Agency. Mention of
trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 11
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Z9 0
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD SEP
PY 2014
VL 107
IS 3
BP 231
EP 241
DI 10.1097/HP.0000000000000101
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AN5FM
UT WOS:000340616100005
PM 25068960
ER
PT J
AU Sherrod, L
Schlosser, K
Kozlowski, A
Bird, B
Werkema, DD
Swiontek, J
AF Sherrod, Laura
Schlosser, Kenneth
Kozlowski, Andrew
Bird, Brian
Werkema, D. Dale, Jr.
Swiontek, Jarred
TI Geophysical Characterization of the Keene Valley Landslide in New York
State
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Article
ID ELECTRICAL-RESISTIVITY TOMOGRAPHY; DEEP-SEATED LANDSLIDE;
SEISMIC-REFRACTION; OCCAMS INVERSION; TURKEY; SLOPE; MOVEMENT; GEOMETRY;
FRANCE
AB The largest naturally occurring landslide in New York State history began in early May 2011. Melting of winter snowpack followed by abnormally high volumes of April rain saturated the underlying glacial stratigraphy and initiated the 0.33 km(2) (82 acre) landslide on Little Porter Mountain in the High-Peaks region of the Adirondack Mountains. Downs lope soil movement rates between 15 and 60 cm per day demonstrated their destructive capacity as the shifting soils caused one house to be condemned because of the unstable ground and foundation while simultaneously rendering three other houses into immediate danger. The mechanisms controlling this landslide were investigated using geophysical methods, displacement measurements, and borehole logs. Nineteen electrical resistivity imaging surveys were implemented to map the subsurface glacial features. Ground penetration radar (GPR) profiles were collected along many of the resistivity lines and additional reconnaissance lines in several other locations. These surveys identified subsurface features such as the buried bedrock surface, thick sequences of loose zones of saturated sediments and clays within the glacial till, and boulder zones. The geophysical data were compared with displacement station measurements and precipitation records, which led to the interpretation that the landslide was triggered by large infiltration and the failure surface was along a clay-sand interface. The nature of the slide is revealed as a deep-seated rotational surface within the glacial deposits instead of the bedrock debris avalanche failures that are considered typical of the Adirondack region. The results of this study assist in the Little Porter Mountain landslide characterization and hazard potential classification of similar glacial deposits on slopes in the Adirondacks region.
C1 [Sherrod, Laura; Schlosser, Kenneth; Swiontek, Jarred] Kutztown State Univ, Dept Phys Sci, Kutztown, PA 19530 USA.
[Kozlowski, Andrew; Bird, Brian] New York State Geol Survey, New York State Museum, Albany, NY 12230 USA.
[Werkema, D. Dale, Jr.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
RP Sherrod, L (reprint author), Kutztown State Univ, Dept Phys Sci, Kutztown, PA 19530 USA.
EM sherrod@kutztown.edu
FU United States Environmental Protection Agency, through its Office of
Research and Development
FX We wish to thank the home owners on Little Porter Mountain in Keene
Valley for site access to the landslide, and the reviewers whose
comments and suggestions significantly improved the manuscript. The
United States Environmental Protection Agency, through its Office of
Research and Development, partially funded and collaborated in this
research. It has been subjected to Agency review and approved for
publication.
NR 46
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Z9 0
U1 1
U2 15
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD SEP
PY 2014
VL 19
IS 3
BP 139
EP 155
DI 10.2113/JEEG19.3.139
PG 17
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA AO2QF
UT WOS:000341169600001
ER
PT J
AU Pachepsky, YA
Blaustein, RA
Whelan, G
Shelton, DR
AF Pachepsky, Y. A.
Blaustein, R. A.
Whelan, G.
Shelton, D. R.
TI Comparing temperature effects on Escherichia coli, Salmonella, and
Enterococcus survival in surface waters
SO LETTERS IN APPLIED MICROBIOLOGY
LA English
DT Article
DE Escherichia coli (all potentially pathogenic types); indicators;
processes; Salmonella; thermal; water quality
ID INDICATOR BACTERIA; FRESH-WATER; DEPENDENCE; MODEL; INACTIVATION;
TYPHIMURIUM; SEAWATER; PLANT; RATES; RIVER
AB The objective of this study was to compare dependency of survival rates on temperature for indicator organisms Escherichia coli and Enterococcus and the pathogen Salmonella in surface waters. A database of 86 survival datasets from peer-reviewed papers on inactivation of E. coli, Salmonella and Enterococcus in marine waters and of E. coli and Salmonella in lake waters was assembled. The Q(10) model was used to express temperature effect on survival rates obtained from linear sections of semi-logarithmic survival graphs. Available data were insufficient to establish differences in survival rates and temperature dependencies for marine waters where values of Q(10) = 3 and a survival rate of 0.7 day(-1) could be applied. The Q(10) values in lake waters were substantially lower in marine waters, and Salmonella inactivation in lake water was, on average, twice as fast as E. coli; data on E. coli substantially outnumber data on Enterococcus and Salmonella. The relative increase in inactivation with increase in temperature is higher in marine waters than lake water, and differences in inactivation between Salmonella and E. coli at a given temperature were significant in lake water but not in marine waters.
C1 [Pachepsky, Y. A.; Blaustein, R. A.; Shelton, D. R.] ARS, USDA, Environm Microbial & Food Safety Lab, Beltsville Agr Res Ctr, Beltsville, MD USA.
[Whelan, G.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA USA.
RP Pachepsky, YA (reprint author), 10300 Baltimore Ave Bldg 173, Beltsville, MD 20705 USA.
EM yakov.pachepsky@ars.usda.gov
OI Pachepsky, Yakov/0000-0003-0232-6090
FU United States Environmental Protection Agency through its Office of
Research and Development [DW-12-92348101]
FX The United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated in the
research described here under contract DW-12-92348101 to the USDA-ARS.
It has been subjected to agency review and approved for publication.
NR 31
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U1 5
U2 57
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0266-8254
EI 1472-765X
J9 LETT APPL MICROBIOL
JI Lett. Appl. Microbiol.
PD SEP
PY 2014
VL 59
IS 3
BP 278
EP 283
DI 10.1111/lam.12272
PG 6
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AN6DO
UT WOS:000340684400004
PM 24739086
ER
PT J
AU Tal, TL
McCollum, CW
Harris, PS
Olin, J
Kleinstreuer, N
Wood, CE
Hans, C
Shah, S
Merchant, FA
Bondesson, M
Knudsen, TB
Padilla, S
Hemmer, MJ
AF Tal, T. L.
McCollum, C. W.
Harris, P. S.
Olin, J.
Kleinstreuer, N.
Wood, C. E.
Hans, C.
Shah, S.
Merchant, F. A.
Bondesson, M.
Knudsen, T. B.
Padilla, S.
Hemmer, M. J.
TI Immediate and long-term consequences of vascular toxicity during
zebrafish development
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Adverse outcome pathway; EGFR; Intersegmental vessel; VEGFR2
ID GROWTH-FACTOR RECEPTOR; GENOMIC REGULATORY BLOCKS; DANIO-RERIO;
SCREENING ASSAY; EGF RECEPTOR; MICE LACKING; DEFECTS; EMBRYOS;
IDENTIFICATION; DISRUPTION
AB Proper formation of the vascular system is necessary for embryogenesis, and chemical disruption of vascular development may be a key event driving developmental toxicity. In order to test the effect of environmental chemicals on this critical process, we evaluated a quantitative assay in transgenic zebrafish using angiogenesis inhibitors that target VEGFR2 (PTK787) or EGFR (AG1478). Both PTK787 and AG1478 exposure impaired intersegmental vessel (ISV) sprouting, while AG1478 also produced caudal and pectoral fin defects at concentrations below those necessary to blunt ISV morphogenesis. The functional consequences of vessel toxicity during early development included decreased body length and survival in juvenile cohorts developmentally exposed to inhibitor concentrations sufficient to completely block ISV sprouting angiogenesis. These data show that concentration-dependent disruption of the presumed targets for these inhibitors produce adverse outcomes at advanced life stages. Published by Elsevier Inc.
C1 [Tal, T. L.; Olin, J.; Wood, C. E.; Padilla, S.] US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[McCollum, C. W.; Bondesson, M.] Univ Houston, Dept Biol & Biochem, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA.
[Harris, P. S.; Hemmer, M. J.] US EPA, Gulf Ecol Div, NHEERL, Gulf Breeze, FL USA.
[Kleinstreuer, N.; Knudsen, T. B.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Hans, C.; Merchant, F. A.] Univ Houston, Dept Comp Sci, Houston, TX 77204 USA.
[Shah, S.; Merchant, F. A.] Univ Houston, Dept Engn Technol, Houston, TX USA.
RP Tal, TL (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,B105-03, Res Triangle Pk, NC 27711 USA.
EM tal.tamara@epa.gov
OI McCollum, Catherine/0000-0002-2238-803X; Kleinstreuer,
Nicole/0000-0002-7914-3682
FU EPA Texas-Indiana University Virtual STAR Grant [R834289]
FX We are grateful to Alisha Palekar for measuring blinded images. We
greatly appreciate Earl Puckett for fabricating the lateral orientation
tool and stage adaptor. The authors thank Gabriele Daniels for her
technical assistance with the juvenile studies and Alan Tennant for
microscopy and imaging assistance. We thank Kim Howard, Ned Collins and
Leslie Martin for fish husbandry and Jeffrey Wolf at Experimental
Pathology Laboratories, INC. for histopathology peer review. We thank
the Zebrafish International Resource Center (RR12546) for providing
Tg(kdrl:EGFP)s843/+ zebrafish embryos. CWM and MB were
supported by the EPA Texas-Indiana University Virtual STAR Grant
(R834289). We are grateful to William Mundy and E. Sidney Hunter for
their critical review of the manuscript. This manuscript has been
reviewed by the U.S. Environmental Protection Agency and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 54
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Z9 3
U1 2
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD SEP
PY 2014
VL 48
SI SI
BP 51
EP 61
DI 10.1016/j.reprotox.2014.05.014
PG 11
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA AO4WK
UT WOS:000341341900006
PM 24907688
ER
PT J
AU Zucker, R
AF Zucker, Robert
TI Separating the Signal from the Noise: Expanding Flow Cytometry into the
Sub-micron Range
SO CYTOMETRY PART A
LA English
DT Editorial Material
C1 US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Zucker, R (reprint author), US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Drop B105-04, Res Triangle Pk, NC 27711 USA.
EM zucker.robert@epa.gov
NR 3
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4922
EI 1552-4930
J9 CYTOM PART A
JI Cytom. Part A
PD SEP
PY 2014
VL 85A
IS 9
BP 744
EP 745
DI 10.1002/cyto.a.22515
PG 2
WC Biochemical Research Methods; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AN4CR
UT WOS:000340535700003
PM 25139806
ER
PT J
AU Caffrey, JM
Murrell, MC
Amacker, KS
Harper, JW
Phipps, S
Woodrey, MS
AF Caffrey, Jane M.
Murrell, Michael C.
Amacker, Kendra S.
Harper, Jennifer W.
Phipps, Scott
Woodrey, Mark S.
TI Seasonal and Inter-annual Patterns in Primary Production, Respiration,
and Net Ecosystem Metabolism in Three Estuaries in the Northeast Gulf of
Mexico (vol 37, pg S222, 2014)
SO ESTUARIES AND COASTS
LA English
DT Correction
C1 [Caffrey, Jane M.; Amacker, Kendra S.] Univ W Florida, Ctr Diagnost & Bioremediat, Pensacola, FL 32514 USA.
[Murrell, Michael C.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Harper, Jennifer W.] Apalachicola Bay Natl Estuarine Res Reserve, Eastpoint, FL 32328 USA.
[Phipps, Scott] Weeks Bay Natl Estuarine Res Reserve, Fairhope, AL 36567 USA.
[Woodrey, Mark S.] Grand Bay Natl Estuarine Res Reserve, Moss Point, MS 39564 USA.
[Woodrey, Mark S.] Mississippi State Univ, Coastal Res & Extens Ctr, Biloxi, MS 39532 USA.
RP Caffrey, JM (reprint author), Univ W Florida, Ctr Diagnost & Bioremediat, 11000 Univ Pkwy, Pensacola, FL 32514 USA.
EM jcaffrey@uwf.edu; murrell.michael@epa.gov; amacker.kendra@gmail.com;
jennifer.harper@dep.state.fl.us; scott.phipps@dcnr.alabama.gov;
msw103@ra.msstate.edu
NR 1
TC 0
Z9 0
U1 4
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD SEP
PY 2014
VL 37
IS 5
BP 1312
EP 1312
DI 10.1007/s12237-014-9856-8
PG 1
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AN3MR
UT WOS:000340492800020
ER
PT J
AU Duan, WL
He, B
Takara, K
Luo, PP
Nover, D
Yamashiki, Y
Huang, WR
AF Duan, Weili
He, Bin
Takara, Kaoru
Luo, Pingping
Nover, Daniel
Yamashiki, Yosuke
Huang, Wenrui
TI Anomalous atmospheric events leading to Kyushu's flash floods, July
11-14, 2012
SO NATURAL HAZARDS
LA English
DT Article
DE Kyushu flash floods; Synoptic climatology; Atmospheric anomalous;
Reanalysis data
ID WEATHER EVENTS; UNITED-STATES; RAINFALL; JAPAN; CLIMATOLOGY; REANALYSIS;
PATTERNS; PROJECT; SEASON; RIVER
AB During July 11-14, 2012, deadly floods and landslides triggered by a series of unprecedented heavy rains hit Kyushu, Japan, causing at least 32 deaths and around 400,000 evacuations. We focus on synoptic anomalies identified after inspecting rainfall patterns and documenting the conditions associated with this tragic event using data combined from the Global Rainfall Map in Near Real Time data, the NCEP/NCAR Reanalysis dataset, and the global forecast system. Rainfall maps indicated that there were many heavy rains in Kyushu in these days and this disaster was associated with the pattern of forecasts and standardized anomalies. A weather trough with positive height anomalies appeared, the center of which moved to the north of Japan over this period, which might cause wind anomalies and whereby lots of water vapor were transported to Kyushu area with up to 90 m s(-1), and high values of precipitable water formed with up to 60 mm. These results suggest that a larger-scale pattern is conducive for heavy rainfall and the anomalies put the pattern in context as to the potential for an extreme rainfall event, which can provide insights and methods for predicting extreme events' or something similar.
C1 [Duan, Weili] Kyoto Univ, Grad Sch Engn, Dept Civil & Earth Resources Engn, Kyoto, Japan.
[Duan, Weili; He, Bin] Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, Nanjing 210008, Jiangsu, Peoples R China.
[He, Bin; Takara, Kaoru] Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Kyoto, Japan.
[Luo, Pingping; Yamashiki, Yosuke] Kyoto Univ, Disaster Prevent Res Inst, Kyoto, Japan.
[Nover, Daniel] US EPA, ORD, NCEA, Washington, DC 20010 USA.
[Huang, Wenrui] Tongji Univ, Key Lab Yangtze River Water Environm, Minist Educ, Dept Hydraul Engn, Shanghai 200092, Peoples R China.
RP Duan, WL (reprint author), Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, Nanjing 210008, Jiangsu, Peoples R China.
EM duan.scut.cn@gmail.com; hebin@niglas.ac.cn
FU Kyoto University; Japan Society for the Promotion of Science [P12055];
JSPS KAKENHI [24.02055]; Chinese Academy of Sciences; China Scholarship
Council (CSC)
FX This study is sponsored by the Kyoto University Global COE program
"Sustainability/Survivability Science for a Resilient Society Adaptable
to Extreme Weather Conditions" and "Global Center for Education and
Research on Human Security Engineering for Asian Megacities," the
Postdoctoral fellowship of Japan Society for the Promotion of Science
(P12055), JSPS KAKENHI Grant Number 24.02055 and the "One Hundred
talents Program" of Chinese Academy of Sciences. The authors wish to
acknowledge Prof. Richard H. Grumm for his help about understanding the
standardized anomalies. The first author would like to thank China
Scholarship Council (CSC) for his PhD scholarships.
NR 33
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Z9 7
U1 2
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
EI 1573-0840
J9 NAT HAZARDS
JI Nat. Hazards
PD SEP
PY 2014
VL 73
IS 3
BP 1255
EP 1267
DI 10.1007/s11069-014-1134-3
PG 13
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA AN3MQ
UT WOS:000340492700005
ER
PT J
AU Uehara, S
Murayama, N
Nakanishi, Y
Nakamura, C
Hashizume, T
Zeldin, DC
Yamazaki, H
Uno, Y
AF Uehara, Shotaro
Murayama, Norie
Nakanishi, Yasuharu
Nakamura, Chika
Hashizume, Takanori
Zeldin, Darryl C.
Yamazaki, Hiroshi
Uno, Yasuhiro
TI Immunochemical detection of cytochrome P450 enzymes in small intestine
microsomes of male and female untreated juvenile cynomolgus monkeys
SO XENOBIOTICA
LA English
DT Article
DE CYP; drug metabolism; jejunum
ID LIVER-MICROSOMES; DRUG-METABOLISM; CYP2C76; CYP2J2; IDENTIFICATION;
INVOLVEMENT; EXPRESSION; ENCODES; GENE
AB 1. The expression of small intestinal cytochromes P450 (P450s) has not been systematically measured in cynomolgus monkeys, which are widely used in preclinical drug studies to predict pharmacokinetics and toxicity in humans: therefore, P450 content of small intestine was quantified in 35 cynomolgus monkeys by immunoblotting using 11 selective antibodies.
2. CYP2D, CYP2J2, CYP3A4 and CYP3A5 were detected in all 35 animals, while CYP1A and CYP2C9/19 were detected in 31 and 17 animals, respectively. CYP2C9 and CYP2C19 were detected with the same antibody. CYP1D, CYP2A, CYP2B6, CYP2C76 and CYP2E1 were not detected in any of the 35 animals examined.
3. On analysis of pooled microsomes (35 animals), CYP3A (3A4 + 3A5) was most abundant (79% of total immunoquantified CYP1-3 proteins), followed by CYP2J2 (13%), CYP2C9/19 (4%), CYP1A (3%) and CYP2D (0.4%). On the analysis of individual microsome samples, each P450 content varied 2-to-6-fold between animals, and no sex differences were observed in any P450 content.
4. These findings should help to increase the understanding of drug metabolism, especially the first-pass effect, in cynomolgus monkey small intestines.
C1 [Uehara, Shotaro; Nakanishi, Yasuharu; Nakamura, Chika; Uno, Yasuhiro] Shin Nippon Biomed Labs Ltd, Pharmacokinet & Bioanal Ctr, Kainan, Wakayama 6420017, Japan.
[Murayama, Norie; Yamazaki, Hiroshi] Showa Pharmaceut Univ, Lab Drug Metab & Pharmacokinet, Machida, Tokyo, Japan.
[Hashizume, Takanori] Osaka Ohtani Univ, Fac Pharm, Tondabayashi, Osaka, Japan.
[Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, Res Triangle Pk, NC USA.
RP Uno, Y (reprint author), Shin Nippon Biomed Labs Ltd, Pharmacokinet & Bioanal Ctr, Genome Res Grp, 16-1 Minami Akasaka, Kainan, Wakayama 6420017, Japan.
EM uno-yasuhiro@snbl.co.jp
OI Yamazaki, Hiroshi/0000-0002-1068-4261
FU Intramural Research Program of the NIH, National Institute of
Environmental Health Sciences
FX This work was supported, in part, by the Intramural Research Program of
the NIH, National Institute of Environmental Health Sciences.
NR 28
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U2 8
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0049-8254
EI 1366-5928
J9 XENOBIOTICA
JI Xenobiotica
PD SEP
PY 2014
VL 44
IS 9
BP 769
EP 774
DI 10.3109/00498254.2014.895882
PG 6
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA AN3CN
UT WOS:000340462600001
PM 24593267
ER
PT J
AU Steffens, JT
Heist, DK
Perry, SG
Isakov, V
Baldauf, RW
Zhang, KM
AF Steffens, Jonathan T.
Heist, David K.
Perry, Steven G.
Isakov, Vlad
Baldauf, Richard W.
Zhang, K. Max
TI Effects of roadway configurations on near-road air quality and the
implications on roadway designs
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Emissions; CFD; Sustainable communities; Urban planning
ID AEROSOL DYNAMICS; WIND-TUNNEL; DISTRIBUTIONS; ENVIRONMENT; DISPERSION;
TURBULENCE; BARRIER; FIELD; MODEL
AB This paper presents an analysis of wind tunnel experiments of twelve different roadway configurations and modeling of these configurations using a Large-Eddy Simulation (LES) model, aiming at investigating how flow structures affect the impact of roadway features on near-road and on-road air quality. The presence of roadside barriers, elevated fill and depressed roadways, and combinations of these configurations all reduce ground-level air pollutant concentrations immediately downwind of roadways. However, all of these cases, except the elevated fill configuration, increase pollutant concentrations on the roadway itself. For a roadside barrier with finite length, higher concentrations than those without a barrier are present in a small region near the edge of the barrier, influenced by complex flow in that region which we term "Edge Effects". The inclusion of multiple roadway features often result in lower downwind pollutant concentrations than those with single roadway features; however, adding features typically offers diminishing returns in concentration reduction. Generally, the effects on concentration, both beneficial and adverse will damp out within 15 multiples of the characteristic height, be it the barrier height or the elevation/depression height of the roadway. Thus, evaluating the trade-off between the air pollutant reductions near the ground and the air pollutant increases on the roadway and elevated above the ground will be important in designing a sustainable transportation system. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Steffens, Jonathan T.; Zhang, K. Max] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA.
[Heist, David K.; Perry, Steven G.; Isakov, Vlad] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Baldauf, Richard W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Baldauf, Richard W.] US EPA, Off Air & Radiat, Off Transportat & Air Qual, Natl Vehicle & Fuel Emiss Lab, Ann Arbor, MI USA.
RP Zhang, KM (reprint author), Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA.
EM kz33@cornell.edu
FU The United States Environmental Protection Agency through its Office of
Research and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research of DKH, SGP, VI
and RWB described here. It has been subjected to Agency's administrative
review and approved for publication.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD SEP
PY 2014
VL 94
BP 74
EP 85
DI 10.1016/j.atmosenv.2014.05.015
PG 12
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AN1AY
UT WOS:000340316300009
ER
PT J
AU Rumsey, IC
Aneja, VP
Lonneman, WA
AF Rumsey, Ian C.
Aneja, Viney P.
Lonneman, William A.
TI Characterizing reduced sulfur compounds emissions from a swine
concentrated animal feeding operation
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Reduced sulfur compounds; Hydrogen sulfide; CAFO emissions; Swine
ID HYDROGEN-SULFIDE EMISSIONS; VOLATILE ORGANIC-COMPOUNDS; FLAME IONIZATION
DETECTOR; EASTERN NORTH-CAROLINA; ODOR; AMMONIA; QUANTIFICATION;
PREDICTION; FACILITIES; HEALTH
AB Reduced sulfur compounds (RSCs) emissions from concentrated animal feeding operations (CAFOs) have become a potential environmental and human health concern, as a result of changes in livestock production methods. RSC emissions were determined from a swine CAFO in North Carolina. RSC measurements were made over a period of approximate to 1 week from both the barn and lagoon during each of the four seasonal periods from June 2007 to April 2008. During sampling, meteorological and other environmental parameters were measured continuously. Seasonal hydrogen sulfide (H2S) barn concentrations ranged from 72 to 631 ppb. Seasonal dimethyl sulfide (DMS; CH3SCH3) and dimethyl disulfide (DMDS; CH3S2CH3) concentrations were 2-3 orders of magnitude lower, ranging from 0.18 to 0.89 ppb and 0.47 to 1.02 ppb, respectively. The overall average barn emission rate was 3.3 g day(-1) AU(-1) (AU (animal unit) = 500 kg of live animal weight) for H2S, which was approximately two orders of magnitude higher than the DMS and DMDS overall average emissions rates, determined as 0.017 g day(-1) AU(-1) and 0.036 g day(-1) AU(-1), respectively. The overall average lagoon flux was 1.33 mu g m(-2) min(-1) for H2S, which was approximately an order of magnitude higher than the overall average DMS (0.12 mu g m(-2) min(-1)) and DMDS (0.09 mu g m(-2) min(-1)) lagoon fluxes. The overall average lagoon emission for H2S (0.038 g day(-1) AU(-1)) was also approximately an order of magnitude higher than the overall average DMS (0.0034 g day(-1) AU(-1)) and DMDS (0.0028 g day(-1) AU(-1)) emissions. H2S, DMS and DMDS have offensive odors and low odor thresholds. Over all four sampling seasons, 77% of 15 min averaged H2S barn concentrations were an order of magnitude above the average odor threshold. During these sampling periods, however, DMS and DMDS concentrations did not exceed their odor thresholds. The overall average barn and lagoon emissions from this study were used to help estimate barn, lagoon and total (barn + lagoon) RSC emissions from swine CAFOs in North Carolina. Total (barn + lagoon) H2S emissions from swine CAFOs in North Carolina were estimated to be 1.22*10(6) kg yr(-1). The barns had significantly higher H2S emissions than the lagoons, contributing approximate to 98% of total North Carolina H2S swine CAFO emissions. Total (barn + lagoon) emissions for DMS and DMDS were 1-2 orders of magnitude lower, with barns contributing approximate to 86% and approximate to 93% of total emissions, respectively. H2S swine CAFO emissions were estimated to contribute approximate to 18% of North Carolina H2S emissions. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Rumsey, Ian C.; Aneja, Viney P.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Lonneman, William A.] US EPA, Sr Environm Employment Program, Res Triangle Pk, NC 27711 USA.
RP Rumsey, IC (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM rumsey.ian@epa.gov
FU United States Department of Agriculture [NRI 2003-055360]
FX Financial support for this research was provided by the United States
Department of Agriculture as part of contract NRI 2003-055360. We
sincerely thank the farm owner for his cooperation. We would like to
acknowledge Dr. Phillip Westerman, Dr. Joette Steger, Kristen James, and
Mark Yirka for their assistance. We are also grateful to the late Bob
Seila of the U.S. EPA for his assistance.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD SEP
PY 2014
VL 94
BP 458
EP 466
DI 10.1016/j.atmosenv.2014.05.041
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AN1AY
UT WOS:000340316300050
ER
PT J
AU Batterman, S
Chambliss, S
Isakov, V
AF Batterman, Stuart
Chambliss, Sarah
Isakov, Vlad
TI Spatial resolution requirements for traffic-related air pollutant
exposure evaluations
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air pollution; Exposure; Exposure misclassification; Traffic
ID MODELS; HEALTH; DISPERSION; ROADWAY; GIS; PROXIMITY; DOWNWIND
AB Vehicle emissions represent one of the most important air pollution sources in most urban areas, and elevated concentrations of pollutants found near major roads have been associated with many adverse health impacts. To understand these impacts, exposure estimates should reflect the spatial and temporal patterns observed for traffic-related air pollutants. This paper evaluates the spatial resolution and zonal systems required to estimate accurately intraurban and near-road exposures of traffic-related air pollutants. The analyses use the detailed information assembled for a large (800 km(2)) area centered on Detroit, Michigan, USA. Concentrations of nitrogen oxides (NOx) due to vehicle emissions were estimated using hourly traffic volumes and speeds on 9700 links representing all but minor roads in the city, the MOVES2010 emission model, the RUNE dispersion model, local meteorological data, a temporal resolution of 1 h, and spatial resolution as low as 10 m. Model estimates were joined with the corresponding shape files to estimate residential exposures for 700,000 individuals at property parcel, census block, census tract, and ZIP code levels. We evaluate joining methods, the spatial resolution needed to meet specific error criteria, and the extent of exposure misclassification. To portray traffic-related air pollutant exposure, raster or inverse distance-weighted interpolations are superior to nearest neighbor approaches, and interpolations between receptors and points of interest should not exceed about 40 m near major roads, and 100 m at larger distances. For census tracts and ZIP codes, average exposures are overestimated since few individuals live very near major roads, the range of concentrations is compressed, most exposures are misclassified, and high concentrations near roads are entirely omitted. While smaller zones improve performance considerably, even block-level data can misclassify many individuals. To estimate exposures and impacts of traffic-related pollutants accurately, data should be geocoded or estimated at the most-resolved spatial level; census tract and larger zones have little if any ability to represent intraurban variation in traffic-related air pollutant concentrations. These results are based on one of the most comprehensive intraurban modeling studies in the literature and results are robust. Additional recommendations address the value of dispersion models to portray spatial and temporal variation of air pollutants in epidemiology and other studies; techniques to improve accuracy and reduce the computational burden in urban scale modeling; the necessary spatial resolution for health surveillance, demographic, and pollution data; and the consequences of low resolution data in terms of exposure misclassification. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Batterman, Stuart] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Chambliss, Sarah] Int Council Clean Transportat, San Francisco, CA 94104 USA.
[Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Batterman, S (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Room 6075 SPH2,1420 Washington Hts, Ann Arbor, MI 48109 USA.
EM stuartb@umich.edu; 2sarah@theicct.org; Isakov.Vlad@epa.gov
FU Graham Environmental Sustainability Institute; Office of Research and
Development at the US Environmental Protection Agency [R834117];
National Institute of Environmental Health Sciences (NIEHS) [5R01
ESO14677-02, R01 ES016769-01]; "Lifestage exposures and adult disease"
as did the Health Effects Institute [P30ES017885]
FX Funding sources that supported this research included the Graham
Environmental Sustainability Institute, the Office of Research and
Development at the US Environmental Protection Agency under cooperative
agreement R834117 (University of Michigan), and the National Institute
of Environmental Health Sciences (NIEHS) through grants 5R01 ESO14677-02
and R01 ES016769-01 for NEXUS. NIEHS provided additional support in
grant P30ES017885 "Lifestage exposures and adult disease" as did the
Health Effects Institute. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. This article
has been reviewed in accordance with U.S. Environmental Protection
Agency policy and approved for publication.
NR 37
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD SEP
PY 2014
VL 94
BP 518
EP 528
DI 10.1016/j.atmosenv.2014.05.065
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AN1AY
UT WOS:000340316300056
PM 25132794
ER
PT J
AU Hand, JL
Schichtel, BA
Malm, WC
Copeland, S
Molenar, JV
Frank, N
Pitchford, M
AF Hand, J. L.
Schichtel, B. A.
Malm, W. C.
Copeland, S.
Molenar, J. V.
Frank, N.
Pitchford, M.
TI Widespread reductions in haze across the United States from the early
1990s through 2011
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Haze; Visibility; Aerosol trends; Remote aerosols
ID SIMULATION TECHNIQUES; PARTICULATE SULFATE; TRENDS; VISIBILITY;
SOUTHEASTERN; EXTINCTION; AEROSOLS; CARBON; PM2.5
AB Visibility has improved significantly at many remote areas across the United States since the early 1990s. Trends in visibility were calculated using ambient light extinction coefficients (b(ext)) estimated from speciated particulate concentrations measured by the IMPROVE (Interagency Monitoring of Protected Visual Environments) network. The 20% haziest bext levels were computed for each year following Regional Haze Rule guidelines and aggregated over three major regions of the United States. Over the last two decades (1992-2011) the regional mean 20% haziest b(ext) dropped by 52% (-2.6% yr(-1), p < 0.01) in the eastern United States, and by 20% (-1.0% yr(-1), p = 0.08) for sites along the West Coast. However, in the Intermountain/Southwest region, the trend was insignificant (-0.2% yr(-1), p = 0.36). Over the last decade (2002-2011) the haziest bext in the Intermountain/Southwest region decreased by 15% (-1.5% yr(-1), p = 0.09), compared to a decrease of 35% (-3.5% yr(-1), p = 0.06) in the West Coast region and 50% (-5.0% yr(-1), p = 0.02) in the East. A novel aspect to this study is the visualization of trends through the simulation of images of national parks and other remote areas for early and current haziest conditions. These images are an effective means for communicating trends and illustrate the dramatic improvement in visibility, especially in the East, where reductions in sulfate concentrations and sulfur dioxide emissions have had a positive impact on visibility degradation. However, while conditions are clearer for regions in the West, less improvement points to the need for understanding the influences on the trends in haziest conditions in those regions. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hand, J. L.; Malm, W. C.; Copeland, S.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
[Schichtel, B. A.] Colorado State Univ, Cooperat Inst Res Atmosphere, Natl Pk Serv, Ft Collins, CO 80523 USA.
[Molenar, J. V.] Air Resource Specialists, Ft Collins, CO 80525 USA.
[Frank, N.] US EPA, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA.
[Pitchford, M.] Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA.
RP Hand, JL (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
EM jlhand@colostate.edu
FU National Park Service [H2370094000]
FX This work was funded by the National Park Service under contract
H2370094000. The assumptions, findings, conclusions, judgments, and
views presented herein are those of the authors and should not be
interpreted as necessarily representing the National Park Service
policies. We thank Jim Renfro at Great Smoky Mountains National Park for
useful discussions.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD SEP
PY 2014
VL 94
BP 671
EP 679
DI 10.1016/j.atmosenv.2014.05.062
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AN1AY
UT WOS:000340316300071
ER
PT J
AU Wickham, J
Wade, TG
Riitters, KH
AF Wickham, J.
Wade, T. G.
Riitters, K. H.
TI An isoline separating relatively warm from relatively cool wintertime
forest surface temperatures for the southeastern United States
SO GLOBAL AND PLANETARY CHANGE
LA English
DT Article
DE Afforestation; Albedo; Climate mitigation; MODIS; NLCD; Reforestation
ID LAND-USE; SCALE DEFORESTATION; BOREAL FOREST; CLIMATE; SNOWMELT; CANOPY;
IMPACT; EVAPOTRANSPIRATION; ALGORITHM; RADIATION
AB Forest-oriented climate mitigation policies promote forestation as a means to increase uptake of atmospheric carbon to counteract global warming. Some have pointed out that a carbon-centric forest policy may be overstated because it discounts biophysical aspects of the influence of forests on climate. In extra-tropical regions, many climate models have shown that forests tend to be warmer than grasslands and croplands because forest albedos tend to be lower than non-forest albedos. A lower forest albedo results in higher absorption of solar radiation and increased sensible warming that is not offset by the cooling effects of carbon uptake in extra-tropical regions. However, comparison of forest warming potential in the context of climate models is based on a coarse classification system of tropical, temperate, and boreal. There is considerable variation in climate within the broad latitudinal zonation of tropical, temperate, and boreal, and the relationship between biophysical (albedo) and biogeochemical (carbon uptake) mechanisms may not be constant within these broad zones. We compared wintertime forest and non-forest surface temperatures for the southeastern United States and found that forest surface temperatures shifted from being warmer than non-forest surface temperatures north of approximately 36 degrees N to cooler south of 36 degrees N. Our results suggest that the biophysical aspects of forests' influence on climate reinforce the biogeochemical aspects of forests' influence on climate south of 36 degrees N. South of 36 degrees N, both biophysical and biogeochemical properties of forests appear to support forestation as a climate mitigation policy. We also provide some quantitative evidence that evergreen forests tend to have cooler wintertime surface temperatures than deciduous forests that may be attributable to greater evapotranspiration rates. Published by Elsevier B.V.
C1 [Wickham, J.; Wade, T. G.] US EPA, Off Res & Dev, Div Environm Sci, Res Triangle Pk, NC 27711 USA.
[Riitters, K. H.] US Forest Serv, USDA, Southern Res Stn, Res Triangle Pk, NC 27709 USA.
RP Wickham, J (reprint author), US EPA, NERL, MD E243-05, Res Triangle Pk, NC 27701 USA.
EM wickham.james@epa.gov
FU United States Environmental Protection Agency (US EPA), through its
Office of Research and Development
FX The United States Environmental Protection Agency (US EPA), through its
Office of Research and Development, funded and managed the research
described here. It has been subjected to Agency review and approved for
publication. Approval does not signify that the contents reflect the
views of US EPA. We thank Megan Mehaffey (US EPA) and X anonymous
reviewers for their helpful comments on earlier drafts of the paper. We
also thank Y. Shuai and C. Schaaf for providing the Landsat-based albedo
data and for their insights on various aspects of albedo. The mention of
trade names should not be interpreted as an endorsement or
recommendation of use.
NR 38
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U1 1
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-8181
EI 1872-6364
J9 GLOBAL PLANET CHANGE
JI Glob. Planet. Change
PD SEP
PY 2014
VL 120
BP 46
EP 53
DI 10.1016/j.gloplacha.2014.05.012
PG 8
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA AM9SS
UT WOS:000340221900005
ER
PT J
AU Moya, J
Phillips, L
Sanford, J
Wooton, M
Gregg, A
Schuda, L
AF Moya, Jacqueline
Phillips, Linda
Sanford, Jessica
Wooton, Maureen
Gregg, Anne
Schuda, Laurie
TI A review of physiological and behavioral changes during pregnancy and
lactation: Potential exposure factors and data gaps
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Review
DE dietary exposure; inhalation exposure; personal exposure
ID NEW-YORK-CITY; ENERGY-EXPENDITURE; ACTIVITY PATTERNS; MATERNAL WEIGHT;
PHYSICAL-ACTIVITY; FISH CONSUMPTION; GESTATIONAL-AGE; TOTAL WATER; LEAD
LEVELS; HUMAN-MILK
AB Exposures to environmental contaminants can pose risks to pregnant women's health, their developing fetuses, children, and adults later in their lives. Assessing risks to this potentially susceptible population requires a sound understanding of the physiological and behavioral changes that occur during pregnancy and lactation. Many physiological and anatomical changes occur in a woman's organ systems during the course of pregnancy and lactation. For example, blood volume and cardiac output increase during pregnancy, and other metabolic functions are altered to provide for the demands of the fetus. During lactation, nutritional demands are greater than during pregnancy. There are also changes in behavior during both pregnancy and lactation. For example, water consumption during pregnancy and lactation increases. These behavioral and physiological changes can lead to different environmental exposures than these women might otherwise experience in the absence of pregnancy or lactation. This paper provides a summary of information from the published literature related to behavioral and physiological changes in pregnant and lactating women that may affect their exposure or susceptibility to environmental contaminants, provides potentially useful exposure factor data for this population of women, and highlights data gaps.
C1 [Moya, Jacqueline; Phillips, Linda; Schuda, Laurie] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Sanford, Jessica; Wooton, Maureen; Gregg, Anne] Battelle Mem Inst, Columbus, OH 43201 USA.
RP Moya, J (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Mailcode 8623P,1200 Penn Ave NW, Washington, DC 20460 USA.
EM moya.jacqueline@epa.gov
NR 76
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U1 2
U2 19
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD SEP-OCT
PY 2014
VL 24
IS 5
BP 449
EP 458
DI 10.1038/jes.2013.92
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AN1AX
UT WOS:000340316200001
PM 24424408
ER
PT J
AU Warren, JL
Luben, TJ
Sanders, AP
Brownstein, NC
Herring, AH
Meyer, RE
AF Warren, Joshua L.
Luben, Thomas J.
Sanders, Alison P.
Brownstein, Naomi C.
Herring, Amy H.
Meyer, Robert E.
TI An evaluation of metrics for assessing maternal exposure to agricultural
pesticides
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE epidemiology; personal exposure; pesticides
ID CONGENITAL-ANOMALIES; INFORMATION-SYSTEM; BIRTH-DEFECTS; FETAL-DEATH;
HYPOSPADIAS; ARKANSAS; RISK
AB We evaluate the use of three different exposure metrics to estimate maternal agricultural pesticide exposure during pregnancy. Using a geographic information system-based method of pesticide exposure estimation, we combine data on crop density and specific pesticide application amounts/dates to create the three exposure metrics. For illustration purposes, we create each metric for a North Carolina cohort of pregnant women, 2003-2005, and analyze the risk of congenital anomaly development with a focus on metric comparisons. Based on the results, and the need to balance data collection efforts/computational efficiency with accuracy, the metric which estimates total chemical exposure using application dates based on crop-specific earliest planting and latest harvesting information is preferred. Benefits and drawbacks of each metric are discussed and recommendations for extending the analysis to other states are provided.
C1 [Warren, Joshua L.; Brownstein, Naomi C.; Herring, Amy H.] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
[Luben, Thomas J.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Sanders, Alison P.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Meyer, Robert E.] State Ctr Hlth Stat, North Carolina Div Publ Hlth, Birth Defects Monitoring Program, Raleigh, NC USA.
RP Warren, JL (reprint author), Univ N Carolina, Dept Biostat, 3101 McGavran Greenberg,CB 7420, Chapel Hill, NC 27599 USA.
EM joshuawa@email.unc.edu
OI Brownstein, Naomi/0000-0002-9991-427X; Sanders,
Alison/0000-0001-8252-4016
FU National Institute of Environmental Health Sciences [T32ES007018,
P30ES010126]
FX We thank Andrew Olshan, Professor of Epidemiology and Department Chair
at UNC Chapel Hill, Kristy J. Michie, Supervising Public Health
Epidemiologist at the Monterey County Health Department, and Leon S.
Warren Jr., Agricultural Research Associate in the North Carolina State
University Department of Crop Science for providing helpful input
regarding the metric creation process and general pesticide/crop timing
information. This research was supported in part by grants from the
National Institute of Environmental Health Sciences (T32ES007018,
P30ES010126).
NR 21
TC 1
Z9 1
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD SEP-OCT
PY 2014
VL 24
IS 5
BP 497
EP 503
DI 10.1038/jes.2013.75
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AN1AX
UT WOS:000340316200007
PM 24149974
ER
PT J
AU Srinivasan, RS
Ingwersen, W
Trucco, C
Ries, R
Campbell, D
AF Srinivasan, Ravi S.
Ingwersen, Wesley
Trucco, Christian
Ries, Robert
Campbell, Daniel
TI Comparison of energy-based indicators used in life cycle assessment
tools for buildings
SO BUILDING AND ENVIRONMENT
LA English
DT Article
DE EIO-LCA; ATHENA (R) Impact Estimator; Eco-LCA; Emergy; Life cycle
assessment tools; Environmental building design
ID ECOSYSTEM SERVICES; THERMODYNAMIC FRAMEWORK; EMERGY; CONSTRUCTION;
SYSTEMS; SUSTAINABILITY; EMISSIONS; MODEL; GAS
AB Traditionally, building rating systems focused on, among others, energy used during operational stage. Recently, there is a strong push by these rating systems to include the life cycle energy use of buildings, particularly using Life Cycle Assessment (LCA), by offering credits that can be used to achieve higher certification levels. As LCA-based tools are evolving to meet this growing demand, it is important to include methods that also quantify the impact of energy being used by ecosystems that indirectly contribute to building life cycle energy use. Using a case-study building, this paper provides an up-to-date comparison of energy-based indicators in tools for building assessment, including those that report both conventional life cycle energy and those that also include a wider systems boundary that captures energy use even further upstream. This paper applies two existing LCA tools, namely, an economic input output based model, Economic Input Output LCA, and a process-based model, ATHENA (R) Impact Estimator, to estimate life cycle energy use in an example building. In order to extend the assessment to address energy use further upstream, this paper also tests the Ecologically based LCA tool and an application of the emergy methodology. All of these tools are applied to the full service life of the building, i.e., all stages, namely, raw material formation, product, construction, use, and end-of-life; and their results are compared. Besides contrasting the use of energy-based indicators in building life cycle tools, this paper uncovered major challenges that confront stakeholders in evaluating the built environments using LCA and similar approaches. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Srinivasan, Ravi S.; Trucco, Christian; Ries, Robert] Univ Florida, ME Rinker Sr Sch Construct Management, Gainesville, FL 32611 USA.
[Ingwersen, Wesley] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Campbell, Daniel] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI USA.
RP Srinivasan, RS (reprint author), Univ Florida, ME Rinker Sr Sch Construct Management, Gainesville, FL 32611 USA.
EM sravi@ufl.edu
OI Ingwersen, Wesley/0000-0002-9614-701X
FU EPA
FX Although EPA contributed to this article, the research presented was not
performed by or funded by EPA and was not subject to EPA's quality
system requirements. Consequently, the views, interpretations, and
conclusions expressed in this article are solely those of the authors
and do not necessarily reflect or represent EPA's views or policies.
NR 53
TC 17
Z9 18
U1 7
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0360-1323
EI 1873-684X
J9 BUILD ENVIRON
JI Build. Environ.
PD SEP
PY 2014
VL 79
BP 138
EP 151
DI 10.1016/j.buildenv.2014.05.006
PG 14
WC Construction & Building Technology; Engineering, Environmental;
Engineering, Civil
SC Construction & Building Technology; Engineering
GA AM2QS
UT WOS:000339696500013
ER
PT J
AU Lombi, E
Donner, E
Scheckel, KG
Sekine, R
Lorenz, C
Von Goetz, N
Nowack, B
AF Lombi, Enzo
Donner, Erica
Scheckel, Kirk G.
Sekine, Ryo
Lorenz, Christiane
Von Goetz, Natalie
Nowack, Bernd
TI Silver speciation and release in commercial antimicrobial textiles as
influenced by washing
SO CHEMOSPHERE
LA English
DT Article
DE Silver nanoparticles; Textiles; Washing; Speciation
ID ENGINEERED NANOMATERIALS; NANOPARTICLES; EXPOSURE; IFEFFIT; FABRICS
AB The use of nanoscale Ag in textiles is one the most often mentioned uses of nano-Ag. It has previously been shown that significant amounts of the Ag in the textiles are released upon washing. However, the form of Ag present in the textiles remains largely unknown as product labelling is insufficient. The aim of this study was therefore to investigate the solid phase speciation of Ag in original and washed silver textiles using XANES. The original Ag speciation in the textiles was found to vary greatly between different materials with Ag(0), AgCI, Ag2S, Ag-phosphate, ionic Ag and other species identified. Furthermore, within the same textile a number of different species were found to coexist. This is likely due to a combination of factors such as the synthesis processes at industrial scale and the possible reaction of Ag with atmospheric gases. Washing with two different detergents resulted in marked changes in Ag-speciation. For some textiles the two detergents induced similar transformation, in other textiles they resulted in very different Ag species. This study demonstrates that in functional Ag textiles a variety of different Ag species coexist before and after washing. These results have important implications for the risk assessment of Ag textiles because they show that the metallic Ag is only one of the many silver species that need to be considered. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lombi, Enzo; Donner, Erica; Sekine, Ryo] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Adelaide, SA 5095, Australia.
[Donner, Erica] CRC CARE, Salisbury, SA 5106, Australia.
[Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
[Lorenz, Christiane; Nowack, Bernd] Empa Swiss Fed Labs Mat Sci & Technol, Technol & Soc Lab, CH-9014 St Gallen, Switzerland.
[Lorenz, Christiane; Von Goetz, Natalie] ETH, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland.
RP Lombi, E (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg 10,Mawson Lakes Campus, Adelaide, SA 5095, Australia.
EM enzo.lombi@unisa.edu.au
RI Donner, Erica/A-4809-2012; Sekine, Ryo/F-3721-2013; ID,
MRCAT/G-7586-2011; Nowack, Bernd/B-6425-2008; Lombi, Enzo/F-3860-2013;
OI Donner, Erica/0000-0001-6465-2233; Sekine, Ryo/0000-0001-9980-0603;
Nowack, Bernd/0000-0002-5676-112X; Lombi, Enzo/0000-0003-3384-0375;
Scheckel, Kirk/0000-0001-9326-9241
FU Australian Research Council [FT100100337, FT130101003, DP120101115];
U.S. Environmental Protection Agency through its Office of Research and
Development
FX E.L. and E.D. are recipients of Australian Research Council Future
Fellowships (FT100100337 and FT130101003). The funding support from the
Australian Research Council is also acknowledged in relation to
Discovery Project DP120101115. The U.S. Environmental Protection Agency
through its Office of Research and Development funded and managed a
portion of the research described here. It has not been subject to
Agency review and therefore does not necessarily reflect the views of
the Agency. No official endorsement should be inferred. MRCAT operations
are supported by the Department of Energy and the MRCAT member
institutions. Part of this research was undertaken using the XAS
Beamline at the Australian Synchrotron, Victoria, Australia.
NR 29
TC 32
Z9 33
U1 6
U2 70
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD SEP
PY 2014
VL 111
BP 352
EP 358
DI 10.1016/j.chemosphere.2014.03.116
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AM1JG
UT WOS:000339601600048
PM 24997939
ER
PT J
AU Ruckerl, R
Hampel, R
Breitner, S
Cyrys, J
Kraus, U
Carter, J
Dailey, L
Devlin, RB
Diaz-Sanchez, D
Koenig, W
Phipps, R
Silbajoris, R
Soentgen, J
Soukup, J
Peters, A
Schneider, A
AF Rueckerl, Regina
Hampel, Regina
Breitner, Susanne
Cyrys, Josef
Kraus, Ute
Carter, Jackie
Dailey, Lisa
Devlin, Robert B.
Diaz-Sanchez, David
Koenig, Wolfgang
Phipps, Richard
Silbajoris, Robert
Soentgen, Jens
Soukup, Joleen
Peters, Annette
Schneider, Alexandra
TI Associations between ambient air pollution and blood markers of
inflammation and coagulation/fibrinolysis in susceptible populations
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Air pollution; Inflammation; Diabetes; CRP; GSTM1; Coagulation
ID C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION SURVIVORS;
CORONARY-ARTERY-DISEASE; HEART-RATE-VARIABILITY; PARTICULATE MATTER;
SYSTEMIC INFLAMMATION; PARTICLE NUMBER; DIABETIC INDIVIDUALS; OXIDATIVE
STRESS; URBAN AIR
AB The pathophysiological pathways linking particulate air pollution to cardiovascular disease are still not fully understood. We examined the association between ambient air pollutants and blood markers of inflammation and coagulation/fibrinolysis in three potentially susceptible populations.
Three panels of non-smoking individuals were examined between 3/2007 and 12/2008: 1) with type 2 diabetes mellitus (T2D, n = 83), 2) with impaired glucose tolerance (IGT, n = 104), and 3) with a potential genetic predisposition which could affect detoxifying and inflammatory pathways (n = 87) defined by the null polymorphism for glutathione S-transferase M1 (GSTM1) in combination with a certain single nucleotide polymorphism on the C-reactive protein (CRP) or the fibrinogen gene. Study participants had blood drawn up to seven times every four to six weeks. In total, 1765 blood samples were analysed for CRP, interleukin (IL)-6, soluble CD40 ligand (sCD40L), fibrinogen, myeloperoxidase (MPO), and plasminogen activator inhibitor-1 (PAI-1). Hourly mean values of particulate air pollutants, particle number concentrations in different size ranges and gaseous pollutants were collected at fixed monitoring sites and individual 24 hour averages calculated. Associations between air pollutants and blood markers were analysed for each panel separately and taking the T2D panel and the IGT panel together, using additive mixed models adjusted for long-term time trend and meteorology.
For the panel with potential genetic susceptibility, CRP and MPO increased for most lags, especially with the 5-day average exposure (% change of geometric mean and 95% confidence interval: 22.9% [12.0;34.7] for CRP and 5.0% [0.3;9.9] for MPO per interquartile range of PM2.5). Small positive associations were seen for fibrinogen while sCD40L, PAI-1 and IL-6 mostly decreased in association with air pollution concentrations. Except for positive associations for fibrinogen we did not see significant results with the two other panels.
Participants with potential genetic susceptibility showed a clear association between inflammatory blood biomarkers and ambient air pollutants. Our results support the hypothesis that air pollution increases systemic inflammation especially in susceptible populations which may aggravate atherosclerotic diseases and induce multi-organ damage. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Rueckerl, Regina; Cyrys, Josef; Soentgen, Jens] Univ Augsburg, ESC, D-86135 Augsburg, Germany.
[Rueckerl, Regina; Hampel, Regina; Breitner, Susanne; Cyrys, Josef; Kraus, Ute; Peters, Annette; Schneider, Alexandra] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
[Carter, Jackie; Dailey, Lisa; Devlin, Robert B.; Diaz-Sanchez, David; Silbajoris, Robert; Soukup, Joleen] Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27709 USA.
[Koenig, Wolfgang] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89081 Ulm, Germany.
[Phipps, Richard] Univ Rochester, Sch Med & Dent, Lung Biol & Dis Program, Dept Environm Med, Rochester, NY 14642 USA.
[Peters, Annette] German Ctr Diabet Res DZD eV, Neuherberg, Germany.
RP Ruckerl, R (reprint author), Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany.
EM regina.pithord@helmholtz-muenchen.de;
regina.hampel@helmholtz-muenchen.de;
susanne.breitner@helmholtz-muenchen.de; cyrys@helmholtz-muenchen.de;
ute.kraus@helmholtz-muenchen.de; carterjacIde@epamail.epa.gov;
dailey.lisa@epamail.epa.gov; devlin.robert@epamail.epa.gov;
diaz-sanchez.david@epamail.epa.gov; wolfgang.koenig@uniklinik-ulm.de;
Richard_Phipps@URMGRochester.edu; silbajoris.robert@epamail.epa.gov;
soentgen@wzu.uni-augsburg.de; soukupjoleen@epamail.epa.gov;
peters@helmholtz-muenchen.de; alexandra.schneider@helmholtz-muenchen.de
RI Breitner, Susanne/B-5348-2014; Peters, Annette/A-6117-2011; Schneider,
Alexandra/B-5347-2014;
OI Breitner, Susanne/0000-0002-0956-6911; Cyrys, Josef/0000-0002-2105-8696
FU United States Environmental Protection Agency through STAR (Science to
Achieve Results) [RD 832415]; German Federal Ministry of Education and
Research (BMBF); Helmholtz Zentrum Munchen, German Research Centre for
Environmental Health - German Federal Ministry of Education and
Research; State of Bavaria; NIEHS [ES01247]; Deutsche
Forschungsgemeinschaft (DFG) [RU1453/2-1]
FX This research has been funded in part by the United States Environmental
Protection Agency through STAR (Science to Achieve Results) grant RD
832415 to the University of Rochester. However, the views expressed in
this paper do not necessarily reflect the views of the US EPA and no
official endorsement should be inferred. This study was supported in
part by a grant from the German Federal Ministry of Education and
Research (BMBF) to the German Centre for Diabetes Research (DZD e.V.).
The KORA research platform (KORA, Cooperative Health Research in the
Region of Augsburg) and the MONICA Augsburg studies were initiated and
financed by the Helmholtz Zentrum Munchen, German Research Centre for
Environmental Health (formerly GSF, National Research Centre for
Environment and Health), which is funded by the German Federal Ministry
of Education and Research and by the State of Bavaria. RP's work was
funded in part by the NIEHS grant ES01247. RR's work was funded by the
Deutsche Forschungsgemeinschaft (DFG, grant number RU1453/2-1).
NR 74
TC 21
Z9 21
U1 2
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD SEP
PY 2014
VL 70
BP 32
EP 49
DI 10.1016/j.envint.2014.05.013
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AM2PL
UT WOS:000339693200005
PM 24907704
ER
PT J
AU Lin, YS
Ginsberg, G
Caffrey, JL
Xue, JP
Vulimiri, SV
Nath, RG
Sonawane, B
AF Lin, Yu-Sheng
Ginsberg, Gary
Caffrey, James L.
Xue, Jianping
Vulimiri, Suryanarayana V.
Nath, Raghu G.
Sonawane, Babasaheb
TI Association of body burden of mercury with liver function test status in
the US population
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Liver; Mercury; Methyl mercury; Blood; Urine; Toxicokinetics
ID GAMMA-GLUTAMYL-TRANSPEPTIDASE; METHYL MERCURY; INORGANIC MERCURY;
UNITED-STATES; METHYLMERCURY; GLUTATHIONE; EXPOSURE; BILIARY; DISEASE;
SERUM
AB The majority of mercury (Hg) exposure in the US population is from consumption of fish contaminated with methylmercury (MeHg). Since inorganic Hg is the predominant form excreted in the feces and urine, hepatic biotransformation is a critical step in its normal clearance. This study was set to test the hypothesis that compromised liver function is associated with body burden of Hg as indirectly reflected by Hg sampled in blood and urine. From the National Health and Nutrition Examination Survey (NHANES, 2003-2008), 3769 adults aged 20 years and above were selected for analysis. Hepatic function was inferred from the three standard serum liver-related enzyme activities, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT). Multivariate regression models were used to examine the associations of interest. Although urinary Hg was significantly correlated with serum Hg, the blood-urinary Hg relationship was influenced by liver function, which is also a function of demographic and lifestyle factors (e.g., gender). Although the results were only marginally significant for examined enzymes (p = 0.06-0.08), urinary Hg tended to be lower among subjects with elevated liver enzymes, as compared to those with normal enzyme measurements. Conversely, MeHg generally represents a higher fraction of the total circulating Hg among those with elevated liver enzyme levels, especially among participants with elevations in all three enzymes (p = 0.01). In conclusion, this population-based study identified an association between liver function, serum Hg and urinary Hg. Urinalysis may not be the optimal approach to monitor Hg elimination toxicokinetics or Hg exposure, since the majority of Hg excretion is fecal and the fidelity of urinary excretion may depend on healthy liver function. Future prospective studies are warranted to expand these findings. Published by Elsevier Ltd.
C1 [Lin, Yu-Sheng; Vulimiri, Suryanarayana V.; Nath, Raghu G.; Sonawane, Babasaheb] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Ginsberg, Gary] Connecticut Dept Publ Hlth, Hartford, CT 06134 USA.
[Caffrey, James L.] Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol, Ft Worth, TX 76107 USA.
[Caffrey, James L.] Univ N Texas, Hlth Sci Ctr, Cardiovasc Res Inst, Ft Worth, TX 76107 USA.
[Xue, Jianping] US EPA, Natl Exposure Res Lab, Off Res & Dev, Washington, DC 20460 USA.
RP Lin, YS (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
EM Lin.Yu-Sheng@epa.gov
OI Vulimiri, Suryanarayana/0000-0003-3734-0036
NR 41
TC 3
Z9 3
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD SEP
PY 2014
VL 70
BP 88
EP 94
DI 10.1016/j.envint.2014.05.010
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AM2PL
UT WOS:000339693200009
PM 24908642
ER
PT J
AU Bade, LM
Balakrishnan, CN
Pilgrim, EM
McRae, SB
Luczkovich, JJ
AF Bade, Lyndell M.
Balakrishnan, Christopher N.
Pilgrim, Erik M.
McRae, Susan B.
Luczkovich, Joseph J.
TI A genetic technique to identify the diet of cownose rays, Rhinoptera
bonasus: analysis of shellfish prey items from North Carolina and
Virginia
SO ENVIRONMENTAL BIOLOGY OF FISHES
LA English
DT Article
DE Elasmobranch; Diet; Feeding ecology; Molecular techniques; COI
ID LOWER CHESAPEAKE BAY; DNA; PREDATION; BEHAVIOR; HABITAT; SYSTEM
AB Cownose rays are implicated in the consumption of commercially important shellfish on the U.S. East Coast. We tested this assumption by developing a molecular technique for species identification from cownose ray gut contents. Digestive tracts sampled from 33 rays in Pamlico Sound, NC and Chesapeake Bay, VA contained pieces of partially-digested tissue, well-digested tissue, fluid, and minute shell fragments which made visual identification to the species level nearly impossible. We sequenced the cytochrome oxidase subunit I (COI) for seven locally acquired bivalve species, chosen for their commercial and ecological importance in NC and VA. Sequences were used to design species-specific primers for each bivalve species to amplify polymerase chain reaction (PCR) products. We designed primers such that PCR products were sufficiently different in size to be distinguishable from one another when resolved on an agarose gel, and multiplexing of several species in one reaction was possible. Digestive tract sample testing revealed that cownose rays in Chesapeake Bay ate stout tagelus and soft shell clams. There was no evidence of the rays in the study consuming commercially important oysters, hard clams, and bay scallops. Further sampling over an extended period of time and additional locations is required to confirm these results. Our diagnostic tests could easily be expanded to elucidate the impact of cownose ray predation on prey populations.
C1 [Bade, Lyndell M.; Balakrishnan, Christopher N.; McRae, Susan B.; Luczkovich, Joseph J.] E Carolina Univ, Dept Biol, Greenville, NC 27858 USA.
[Pilgrim, Erik M.] US EPA, Ecol Exposure Res Div, Cincinnati, OH 45268 USA.
[Bade, Lyndell M.] Bates Coll, Dept Biol, Lewiston, ME 04240 USA.
[Bade, Lyndell M.] Bates Coll, Dept Chem, Lewiston, ME 04240 USA.
RP Bade, LM (reprint author), Bates Coll, Dept Biol, Lewiston, ME 04240 USA.
EM lyndell.bade@alumni.ecu.edu
RI Balakrishnan, Christopher/A-3043-2014
OI Balakrishnan, Christopher/0000-0002-0788-0659
FU Institute for Coastal Science and Policy; Department of Biology at East
Carolina University; American Elasmobranch Society; Save Our Seas
Foundation; ECU-American Fisheries Society
FX The authors wish to acknowledge the Institute for Coastal Science and
Policy and the Department of Biology at East Carolina University for
logistics and financial support. Animal collection and handling
procedures were approved by the East Carolina University Animal Use and
Care Committee, Animal Use Protocol #D268. The American Elasmobranch
Society, Save Our Seas Foundation, and the ECU-American Fisheries
Society subunit contributed symposium, publication, travel, and student
funding support. We are grateful for the help of Robert Fisher, Joseph
Smith, R. Dean Grubbs, John Morrissey, Denise Mayer, Captain George
Beckwith, Jason Rock, NCDMF, Lena Keller, Shona Paterson, and for the
generosity of numerous friends and colleagues who helped with shellfish
collection and cownose ray sampling. The authors wish to thank Matthew
Ajemian and Julie A. Neer, symposium organizers and special issue
editors, for their contributions and guidance. The views expressed in
this article are those of the authors and do not necessarily represent
the views or policies of the U.S. Environmental Agency.
NR 31
TC 2
Z9 2
U1 1
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0378-1909
EI 1573-5133
J9 ENVIRON BIOL FISH
JI Environ. Biol. Fishes
PD SEP
PY 2014
VL 97
IS 9
SI SI
BP 999
EP 1012
DI 10.1007/s10641-014-0290-3
PG 14
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AM4CH
UT WOS:000339799100004
ER
PT J
AU Yuan, LL
Pollard, AI
Pather, S
Oliver, JL
D'Anglada, L
AF Yuan, Lester L.
Pollard, Amina I.
Pather, Santhiska
Oliver, Jacques L.
D'Anglada, Lesley
TI Managing microcystin: identifying national-scale thresholds for total
nitrogen and chlorophyll a
SO FRESHWATER BIOLOGY
LA English
DT Article
DE chlorophyll a; cyanotoxins; LASSO regression; microcystin; nutrients
ID CYANOBACTERIA DOMINANCE; CANADIAN LAKES; FINNISH LAKES; FRESH-WATER;
AERUGINOSA; GROWTH; DYNAMICS; LASSO; EUTROPHICATION; PHYTOPLANKTON
AB 1. The occurrence of high cyanotoxin concentrations can severely impair the use of a waterbody for drinking water and recreational purposes. Cyanotoxins are likely to occur under specific environmental conditions, and so identifying these conditions can facilitate management of the waterbody to reduce the likelihood of high cyanotoxin concentrations.
2. We analysed data collected from lakes across the contiguous United States to identify environmental variables that are strongly associated with occurrence of high concentrations of a common cyanotoxin, microcystin (MC).
3. Since many different environmental variables covary and are associated with high MC, we used least absolute shrinkage and selection operator (LASSO) regression to identify a few variables that provided accurate predictions of high MC (>= 1 mu g L-1).
4. Our analysis indicated that total nitrogen (TN) and chlorophyll a (chl a) concentrations yielded a parsimonious model that accurately predicted the occurrence of high MC. Based on this model, we identified management thresholds for TN and chl a that would maintain the probability of high MC at or below 10 and 5%.
C1 [Yuan, Lester L.; Pather, Santhiska; Oliver, Jacques L.; D'Anglada, Lesley] US EPA, Off Sci & Technol, Off Water, Washington, DC 20460 USA.
[Pollard, Amina I.] US EPA, Off Wetlands Oceans & Watersheds, Off Water, Washington, DC 20460 USA.
RP Yuan, LL (reprint author), US EPA, Off Sci & Technol, Off Water, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM yuan.lester@epa.gov
NR 60
TC 8
Z9 9
U1 5
U2 58
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0046-5070
EI 1365-2427
J9 FRESHWATER BIOL
JI Freshw. Biol.
PD SEP
PY 2014
VL 59
IS 9
BP 1970
EP 1981
DI 10.1111/fwb.12400
PG 12
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA AL9SG
UT WOS:000339480500016
ER
PT J
AU Chai, M
Tu, QS
Lu, MM
Yang, YJ
AF Chai, Ming
Tu, Qingshi
Lu, Mingming
Yang, Y. Jeffrey
TI Esterification pretreatment of free fatty acid in biodiesel production,
from laboratory to industry
SO FUEL PROCESSING TECHNOLOGY
LA English
DT Article
DE Acid-catalyzed esterification; Biodiesel; Used cooking oil; Free fatty
acid; Methanol to FFA ratio; Optimization
ID WASTE COOKING OIL; RUBBER SEED OIL; CRUDE PALM OIL; JATROPHA-CURCAS;
OPTIMIZATION; CATALYST; KINETICS; WATER; FUEL; FFA
AB In the US, biodiesel producers usually follow the 19.8:1 methanol-to-FFA molar ratio for free fatty acid (FFA) esterification, as suggested by the National Renewable Energy Laboratory (NREL) without optimization studies. In this paper, both laboratory studies and industrial practices of the esterification process were compared, and an optimization study of a used vegetable oil with 5% FFA was conducted. The optimal conditions of this oil, i.e., methanol-to-FFA molar ratio of 40:1, and sulfuric acid usage of 10%, fell out of the suggested range of 19.8:1. The activation energy of the esterification reaction is 20.7 kJ/mol at the optimized condition and 45.9 kJ/mol at the 19.8:1 methanol to FFA ratio. It was found that the 19.8:1 methanol-to-FFA molar ratio worked well only within the FFA range of 15-25% while the suggested 5% sulfuric acid worked well only within the FFA range of 15-35%. Outside these ranges, especially at FFA levels less than 15%, optimization study is necessary. Regression models of methanol and acid dosing have been utilized in two industrial scale biodiesel producing facilities and have successfully reduced the FFA level to less than 0.5%. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Chai, Ming] Greenleaf Biofuels, New Haven, CT 06512 USA.
[Tu, Qingshi; Lu, Mingming] Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Cincinnati, OH 45221 USA.
[Yang, Y. Jeffrey] US EPA, Natl Risk Management Res Labs, Cincinnati, OH 45221 USA.
RP Lu, MM (reprint author), Univ Cincinnati, Sch Energy Environm Biol & Med Engn, POB 210012, Cincinnati, OH 45221 USA.
EM LUMG@ucmail.uc.edu
FU RET (Research Experiences for Teachers) program of the National Science
Foundation [EEC 0808696, EEC 1004623]; National Risk Management Research
Laboratory; U.S. Environmental Protection Agency
FX The authors acknowledge the financial supports from the RET (Research
Experiences for Teachers) program of the National Science Foundation
(EEC 0808696, EEC 1004623) and the National Risk Management Research
Laboratory, U.S. Environmental Protection Agency. The Cincinnati Zoo and
Botanical Garden is acknowledged for providing the used cooking oil.
NR 34
TC 27
Z9 27
U1 8
U2 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3820
EI 1873-7188
J9 FUEL PROCESS TECHNOL
JI Fuel Process. Technol.
PD SEP
PY 2014
VL 125
BP 106
EP 113
DI 10.1016/j.fuproc.2014.03.025
PG 8
WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical
SC Chemistry; Energy & Fuels; Engineering
GA AJ7KT
UT WOS:000337876300013
ER
PT J
AU Wahman, DG
Speitel, GE
Machavaram, MV
AF Wahman, David G.
Speitel, Gerald E., Jr.
Machavaram, Madhav V.
TI A proposed abiotic reaction scheme for hydroxylamine and monochloramine
under chloramination relevant drinking water conditions
SO WATER RESEARCH
LA English
DT Article
DE Hydroxylamine; Monochloramine; Drinking water; Nitrification; N-15;
Isotopes
ID MONOAZIDE QUANTITATIVE PCR; LIVE/DEAD BACLIGHT METHODS;
NITROSOMONAS-EUROPAEA; NITRIC-OXIDE; DISINFECTION KINETICS;
SUPEROXIDE-DISMUTASE; OXIDATION; DECOMPOSITION; AUTOXIDATION; AMMONIA
AB Drinking water monochloramine (NH2Cl) use may promote ammonia-oxidizing bacteria (AOB). AOB use (i) ammonia monooxygenase for biological ammonia (NH3) oxidation to hydroxylamine (NH2OH) and (ii) hydroxylamine oxidoreductase for NH2OH oxidation to nitrite. NH2Cl and NH2OH may react, providing AOB potential benefits and detriments. The NH2Cl/NH2OH reaction would benefit AOB by removing the disinfectant (NH2Cl) and releasing their growth substrate (NH3), but the NH2Cl/NH2OH reaction would also provide a possible additional inactivation mechanism besides direct NH2Cl reaction with cells. Because biological NH2OH oxidation supplies the electrons required for biological NH3 oxidation, the NH2Cl/NH2OH reaction provides a direct mechanism for NH2Cl to inhibit NH3 oxidation, starving the cell of reductant by preventing biological NH2OH oxidation. To investigate possible NH2Cl/NH2OH reaction implications on AOB, an understanding of the underlying abiotic reaction is first required. The present study conducted a detailed literature review and proposed an abiotic NH2Cl/NH2OH reaction scheme (RS) for chloramination relevant drinking water conditions (mu M concentrations, air saturation, and pH 7-9). Next, RS literature based kinetics and end-products were evaluated experimentally between pHs 7.7 and 8.3, representing (i) the pH range for future experiments with AOB and (ii) mid-range pHs typically found in chloraminated drinking water. In addition, a N-15 stable isotope experiment was conducted to verify nitrous oxide and nitrogen gas production and their nitrogen source. Finally, the RS was slightly refined using the experimental data and an AQUASIM implemented kinetic model. A chloraminated drinking water relevant RS is proposed and provides the abiotic reaction foundation for future AOB biotic experiments. Published by Elsevier Ltd.
C1 [Wahman, David G.] United States Environm Protect Agcy, Off Res & Dev, Cincinnati, OH 45268 USA.
[Speitel, Gerald E., Jr.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA.
[Machavaram, Madhav V.] Pegasus Tech Serv Inc, Cincinnati, OH 45268 USA.
RP Wahman, DG (reprint author), United States Environm Protect Agcy, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM wahman.david@epa.gov
NR 41
TC 2
Z9 2
U1 4
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD SEP 1
PY 2014
VL 60
BP 218
EP 227
DI 10.1016/j.watres.2014.04.051
PG 10
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AJ7FC
UT WOS:000337861600020
PM 24862953
ER
PT J
AU Verkerke, JL
Williams, DJ
Thoma, E
AF Verkerke, Joshua L.
Williams, David J.
Thoma, Eben
TI Remote sensing of CO2 leakage from geologic sequestration projects
SO INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
LA English
DT Review
DE Carbon capture and sequestration (CCS); Geologic sequestration; Climate
change; Remote sensing
ID DIFFERENTIAL ABSORPTION LIDAR; CARBON-DIOXIDE; ATMOSPHERIC CO2; STORAGE
PROJECTS; GAS ANALYZERS; SURFACE; SEEPAGE; PLANT; INTERFEROMETRY;
BOZEMAN
AB Monitoring for leak hazards is an important consideration in the deployment of carbon dioxide geologic sequestration. Failure to detect and correct leaks may invalidate any potential emissions benefits intended by such projects. Presented is a review of remote sensing methods primed to serve a central role in any monitoring program due to their minimally invasive nature and potential for large area coverage in a limited timeframe or in real-time as a continuous monitoring program. Methods investigated were divided into those capable of indirect detection of carbon dioxide leakage, such as monitoring for vegetative stress and ground surface deformation, and those that directly detect gaseous and atmospheric compounds, by means of such tools as Open-Path Fourier Transform Infrared or Tunable Diode Lasers. Both direct and indirect methods present viable means of detecting a leak event, though ultimately, a robust approach will incorporate multiple monitoring tools that may include both direct and indirect remote sensing methods. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Verkerke, Joshua L.; Williams, David J.] US EPA, Landscape Characterizat Branch, Res Triangle Pk, NC 27711 USA.
[Thoma, Eben] US EPA, Emiss Characterizat & Prevent Branch, Res Triangle Pk, NC 27711 USA.
RP Verkerke, JL (reprint author), US EPA, Landscape Characterizat Branch, MC E243-05,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Verkerke.Joshua@EPA.gov
FU US Environmental Protection Agency
FX The authors thank the US Environmental Protection Agency for funding
this work, and the reviewers for their comments and expertise.
NR 73
TC 7
Z9 7
U1 3
U2 60
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0303-2434
J9 INT J APPL EARTH OBS
JI Int. J. Appl. Earth Obs. Geoinf.
PD SEP
PY 2014
VL 31
BP 67
EP 77
DI 10.1016/j.jag.2014.03.008
PG 11
WC Remote Sensing
SC Remote Sensing
GA AI2PQ
UT WOS:000336700900007
ER
PT J
AU Rosenzweig, S
Sorial, GA
Sahle-Demessie, E
McAvoy, DC
AF Rosenzweig, Shirley
Sorial, George A.
Sahle-Demessie, Endalkachew
McAvoy, Drew C.
TI Optimizing the physical-chemical properties of carbon nanotubes (CNT)
and graphene nanoplatelets (GNP) on Cu(II) adsorption
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Adsorption; Carbon nanotubes; Copper; Graphene; pHpzc, Surface modeling
ID ACID; IONS
AB Systematic experiments of copper adsorption on 10 different commercially available nanomaterials were studied for the influence of physical-chemical properties and their interactions. Design of experiment and response surface methodology was used to develop a polynomial model to predict maximum copper adsorption (initial concentration, C-o =10 mg/L) per mass of nanomaterial, q(e), using multivariable regression and maximum R-square criterion. The best subsets of properties to predict qe in order of significant contribution to the model were: bulk density, ID, mesopore volume, tube length, pore size, zeta-charge, specific surface area and OD. The highest experimental qe observed was for an alcohol-functionalized MWCNT (16.7 mg/g) with relative high bulk density (0.48 g/cm(3)), ID (2-5 nm), 10-30 mu m long and OD < 8 nm. Graphene nanoplatelets (GNP) showed poor adsorptive capacity associated to stacked-nanoplatelets, but good colloidal stability due to high functionalized surface. Good adsorption results for pristine SWCNT indicated that tubes with small diameter were more associated with good adsorption than functionalized surface. XPS and ICP analysis explored surface chemistry and purity, but pHpzc and zeta-charge were ultimately applied to indicate the degree of functionalization. Optimum CNT were identified in the scatter plot, but actual manufacturing processes introduced size and shape variations which interfered with final property results. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Rosenzweig, Shirley; Sorial, George A.; McAvoy, Drew C.] Univ Cincinnati, Coll Engn & Appl Sci, Dept Biomed Chem & Environm Engn BCEE, Environm Engn Program, Cincinnati, OH 45221 USA.
[Sahle-Demessie, Endalkachew] US Environm Protect Agcy, NRMRL, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Sorial, GA (reprint author), Univ Cincinnati, Coll Engn & Appl Sci, Dept Biomed Chem & Environm Engn BCEE, Environm Engn Program, POB 210012, Cincinnati, OH 45221 USA.
EM george.sorial@uc.edu
FU U.S. EPA [PRC108- 1170]
FX The authors want to thank Stephen Harmon and Christina Bennett-Stamper
for their work on SEM/EDS and TEM. We also would acknowledge Debby Roose
for running the analysis in the ICP-AES. Special thanks to Liang Yan,
for the BET analysis. This study was supported by U.S. EPA under
contract No. PRC108- 1170.
NR 35
TC 10
Z9 10
U1 6
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD AUG 30
PY 2014
VL 279
BP 410
EP 417
DI 10.1016/j.jhazmat.2014.07.015
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AR2CB
UT WOS:000343390100050
PM 25103452
ER
PT J
AU Cutler, WG
El-Kadi, A
Hue, NV
Peard, J
Scheckel, K
Ray, C
AF Cutler, William G.
El-Kadi, Aly
Hue, Nguyen V.
Peard, John
Scheckel, Kirk
Ray, Chittaranjan
TI Iron amendments to reduce bioaccessible arsenic
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Arsenic; Bioaccessibility; Remediation; Iron amendments; Hawaii
ID CONTAMINATED SOILS; RELATIVE BIOAVAILABILITY; ADSORPTION; PHOSPHATE;
LEAD; STABILIZATION; REMEDIATION; MOLYBDATE; MINERALS; OXIDES
AB Former sugarcane lands on the Island of Hawaii have elevated levels of soil arsenic (As) from historical use of arsenical pesticides. The bioaccessible fraction of total As (As-TOT), a measure of the potential for human As uptake by incidental ingestion of soil, is used in the assessment of human health risk and the determination of the need for remedial action. Ferric chloride plus lime and ferrous sulfate plus lime were applied to As-contaminated soils in a field plot setting to determine the potential for reducing in vitro bioaccessible As (As-IVBA) by increasing As sequestration by the formation of additional iron (Fe) oxyhydroxides. The two Fe sources performed similarly in reducing As-IVBA over a 2-year observation period, with 30-41% reduction in As-IVBA for 0.25 wt% Fe dosing (dry soil basis) and 59-63% reduction for 0.5 wt% Fe dosing. Addition of phosphate (PO4) to treated and untreated soils caused a significant increase in As-IVBA. Iron-treated and control soils showed more than twice the As-IVBA after the addition of 1500 mg P kg(-1). The cost of in situ treatment of As-contaminated soil with ferrous sulfate plus lime to lower AS(IVBA) was estimated to be an order of magnitude less than excavation and landfill disposal on the Island of Hawaii, making the technology a viable alternative when remedial action objectives were based on As-IVBA levels. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Cutler, William G.; El-Kadi, Aly] Integral Consulting Inc, Louisville, CO 80027 USA.
[Cutler, William G.; El-Kadi, Aly] Univ Hawaii Manoa, Dept Geol & Geophys, Honolulu, HI 96822 USA.
[Hue, Nguyen V.] Univ Hawaii Manoa, Dept Trop Plant & Soil Sci, Honolulu, HI 96822 USA.
[Peard, John] Hawaii Dept Hlth, Hilo, HI 96720 USA.
[Scheckel, Kirk] US Environm Protect Agcy, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
[Ray, Chittaranjan] Univ Nebraska, Robert B Daugherty Water Food Inst, Lincoln, NE 68583 USA.
RP Cutler, WG (reprint author), Integral Consulting Inc, 285 Century Pl,Suite 190, Louisville, CO 80027 USA.
EM wcutler@integral-corp.com; elkadi@hawaii.edu; nvhue@hawaii.edu;
john.peard@doh.hawaii.gov; scheckel.kirk@epa.gov; cray@nebraska.edu
OI Scheckel, Kirk/0000-0001-9326-9241
NR 49
TC 4
Z9 4
U1 4
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD AUG 30
PY 2014
VL 279
BP 554
EP 561
DI 10.1016/j.jhazmat.2014.07.043
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AR2CB
UT WOS:000343390100066
PM 25113516
ER
PT J
AU Jalava, K
Rintala, H
Ollgren, J
Maunula, L
Gomez-Alvarez, V
Revez, J
Palander, M
Antikainen, J
Kauppinen, A
Rasanen, P
Siponen, S
Nyholm, O
Kyyhkynen, A
Hakkarainen, S
Merentie, J
Parnanen, M
Loginov, R
Ryu, H
Kuusi, M
Siitonen, A
Miettinen, I
Domingo, JWS
Hanninen, ML
Pitkanen, T
AF Jalava, Katri
Rintala, Hanna
Ollgren, Jukka
Maunula, Leena
Gomez-Alvarez, Vicente
Revez, Joana
Palander, Marja
Antikainen, Jenni
Kauppinen, Ari
Rasanen, Pia
Siponen, Sallamaari
Nyholm, Outi
Kyyhkynen, Aino
Hakkarainen, Sirpa
Merentie, Juhani
Parnanen, Martti
Loginov, Raisa
Ryu, Hodon
Kuusi, Markku
Siitonen, Anja
Miettinen, Ilkka
Domingo, Jorge W. Santo
Hanninen, Marja-Liisa
Pitkanen, Tarja
TI Novel Microbiological and Spatial Statistical Methods to Improve
Strength of Epidemiological Evidence in a Community-Wide Waterborne
Outbreak
SO PLOS ONE
LA English
DT Article
ID REAL-TIME PCR; FIELD GEL-ELECTROPHORESIS; POLYMERASE-CHAIN-REACTION;
CAMPYLOBACTER-JEJUNI; DRINKING-WATER; ENVIRONMENTAL WATERS;
DISTRIBUTION-SYSTEM; HUMAN SAPOVIRUSES; SOUTH-AFRICA; WASTE-WATER
AB Failures in the drinking water distribution system cause gastrointestinal outbreaks with multiple pathogens. A water distribution pipe breakage caused a community-wide waterborne outbreak in Vuorela, Finland, July 2012. We investigated this outbreak with advanced epidemiological and microbiological methods. A total of 473/2931 inhabitants (16%) responded to a web-based questionnaire. Water and patient samples were subjected to analysis of multiple microbial targets, molecular typing and microbial community analysis. Spatial analysis on the water distribution network was done and we applied a spatial logistic regression model. The course of the illness was mild. Drinking untreated tap water from the defined outbreak area was significantly associated with illness (RR 5.6, 95% CI 1.9-16.4) increasing in a dose response manner. The closer a person lived to the water distribution breakage point, the higher the risk of becoming ill. Sapovirus, enterovirus, single Campylobacter jejuni and EHEC O157:H7 findings as well as virulence genes for EPEC, EAEC and EHEC pathogroups were detected by molecular or culture methods from the faecal samples of the patients. EPEC, EAEC and EHEC virulence genes and faecal indicator bacteria were also detected in water samples. Microbial community sequencing of contaminated tap water revealed abundance of Arcobacter species. The polyphasic approach improved the understanding of the source of the infections, and aided to define the extent and magnitude of this outbreak.
C1 [Jalava, Katri; Ollgren, Jukka; Palander, Marja; Rasanen, Pia; Siponen, Sallamaari; Nyholm, Outi; Kyyhkynen, Aino; Kuusi, Markku; Siitonen, Anja] Natl Inst Hlth & Welf, Dept Infect Dis Surveillance & Control, Helsinki, Finland.
[Rintala, Hanna; Hakkarainen, Sirpa; Merentie, Juhani; Parnanen, Martti] Siilinjarvi Municipal, Siilinjarvi, Finland.
[Maunula, Leena; Revez, Joana; Hanninen, Marja-Liisa] Univ Helsinki, Dept Food Hyg & Environm Hlth, Helskinki, Finland.
[Gomez-Alvarez, Vicente; Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Antikainen, Jenni; Loginov, Raisa] Helsinki Univ Hosp, Lab HUSLAB, Helsinki, Finland.
[Kauppinen, Ari; Miettinen, Ilkka; Pitkanen, Tarja] Natl Inst Hlth & Welf, Dept Environm Hlth, Kuopio, Finland.
RP Jalava, K (reprint author), Natl Inst Hlth & Welf, Dept Infect Dis Surveillance & Control, Helsinki, Finland.
EM katri.jalava@thl.fi
RI Pitkanen, Tarja/D-1657-2014
OI Pitkanen, Tarja/0000-0002-7591-9148
NR 79
TC 7
Z9 7
U1 1
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 22
PY 2014
VL 9
IS 8
AR e104713
DI 10.1371/journal.pone.0104713
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO3LL
UT WOS:000341230600018
PM 25147923
ER
PT J
AU Weathers, W
Colon, M
Hines, A
Ulrich, EM
AF Weathers, Walter
Colon, Maribel
Hines, Avis
Ulrich, Elin M.
TI Use of fluorinated polybrominated diphenyl ethers and simplified cleanup
for the analysis of polybrominated diphenyl ethers in house dust
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Flame retardants; Polybrominated diphenyl ethers; House dust;
Fluorinated PBDEs; Solid phase extraction
ID BROMINATED FLAME RETARDANTS; MASS-SPECTROMETRY; HUMAN EXPOSURE; INDOOR
DUST; AIR; HEXABROMOCYCLODODECANE; EXTRACTION; PBDES; ASSOCIATIONS;
CANADA
AB A simple, cost-effective method is described for the analysis of polybrominated diphenyl ethers (PBDEs) in house dust using pressurized fluid extraction, cleanup with modified silica solid phase extraction tubes, and fluorinated internal standards. There are 14 PBDE congeners included in the method, some typically contained in the commercial mixtures used as flame retardants, and some which are not routinely reported in the peer-reviewed literature. A gas chromatographic-mass spectrometry instrumental method provides baseline separation in <20 min, detection limits <20 ng/g, and quantitation limits <60 ng/g for most congeners. Method blanks contained an average concentration <9 ng/g for all congeners except BDE209 which had an average around 40 ng/g. Spiked samples showed good accuracy with relative percent difference (RPD) <7%, and good precision with relative standard deviation <22% for all congeners except BDE209. The method was applied to the analysis of a standard dust (NIST Standard Reference Material 2585) and showed good accuracy with RPD <25% except for BDE154. Overall, this method exhibited good performance characteristics in all categories including simplicity, cost, sensitivity, selectivity, accuracy, and precision. Published by Elsevier B.V.
C1 [Weathers, Walter; Colon, Maribel; Hines, Avis; Ulrich, Elin M.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Ulrich, EM (reprint author), US EPA, 109 TW Alexander Dr,Maildrop D205-05, Res Triangle Pk, NC 27711 USA.
EM colon.maribel@epa.gov; ulrich.elin@epa.gov
NR 34
TC 0
Z9 0
U1 5
U2 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD AUG 22
PY 2014
VL 1356
BP 266
EP 271
DI 10.1016/j.chroma.2014.06.054
PG 6
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA AN0VR
UT WOS:000340302600029
PM 25037776
ER
PT J
AU Chang, HS
Buettner, SW
Seaman, JC
Jaffe, PR
van Groos, PGK
Li, D
Peacock, AD
Scheckel, KG
Kaplan, DI
AF Chang, Hyun-shik
Buettner, Shea W.
Seaman, John C.
Jaffe, Peter R.
van Groos, Paul G. Koster
Li, Dien
Peacock, Aaron D.
Scheckel, Kirk G.
Kaplan, Daniel I.
TI Uranium Immobilization in an Iron-Rich Rhizosphere of a Native Wetland
Plant from the Savannah River Site under Reducing Conditions
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RAY-ABSORPTION-SPECTROSCOPY; CONTAMINATED AQUIFER; MICROBIAL REDUCTION;
CHEMICAL SPECIATION; ASTER-TRIPOLIUM; ORYZA-SATIVA; FERRIC-OXIDE; ROOT
PLAQUE; FE-PLAQUE; SEDIMENTS
AB The hypothesis of this study was that iron plaques formed on the roots of wetland plants and their rhizospheres create environmental conditions favorable for iron reducing bacteria that promote the in situ immobilization of uranium. Greenhouse microcosm studies were conducted using native plants (Sparganium americanum) from a wetland located on the Savannah River Site, Aiken, SC. After iron plaques were established during a 73-day period by using an anoxic Fe(II)-rich nutrient solution, a U(VI) amended nutrient solution was added to the system for an additional two months. Compared to plant-free control microcosms, microcosms containing iron plaques successfully stimulated the growth of targeted iron reducing bacteria, Geobacter spp. Their population continuously increased after the introduction of the U(VI) nutrient solution. The reduction of some of the U(VI) to U(IV) by iron reducing bacteria was deduced based on the observations that the aqueous Fe(II) concentrations increased while the U(VI) concentrations decreased. The Fe(II) produced by the iron reducing bacteria was assumed to be recoddized by the oxygen released from the roots. Advanced spectroscopic analyses revealed that a significant fraction of the U(VI) had been reduced to U(IV) and they were commonly deposited in association with phosphorus on the iron plaque.
C1 [Chang, Hyun-shik; Buettner, Shea W.; Seaman, John C.] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA.
[Jaffe, Peter R.; van Groos, Paul G. Koster] Princeton Univ, Princeton, NJ 08540 USA.
[Li, Dien; Kaplan, Daniel I.] Savannah River Natl Lab, Aiken, SC 29808 USA.
[Peacock, Aaron D.] Microbial Insights Inc, Rockford, TN 37853 USA.
[Scheckel, Kirk G.] US EPA, Cincinnati, OH 45268 USA.
RP Kaplan, DI (reprint author), Savannah River Natl Lab, Aiken, SC 29808 USA.
EM daniel.kaplan@srnl.doe.gov
RI Li, Dien/N-6370-2014;
OI Scheckel, Kirk/0000-0001-9326-9241
FU Subsurface Biogeochemistry Research Program, within the Climate and
Environmental Sciences Division in the Office of Biological and
Environmental Research, Office of Science, U.S. Department of Energy
[Dr-FG02-08ER64567, ER65222-1038426-0017532]; Department of Energy
[DEFC09-07-SR22506]; University of Georgia Research Foundation
[DEFC09-07-SR22506]; Natural Sciences and Engineering Research Council
of Canada; National Research Council Canada; Canadian Institutes of
Health Research; Province of Saskatchewan, Western Economic
Diversification Canada; University of Saskatchewan
FX This work was supported by Subsurface Biogeochemistry Research Program,
within the Climate and Environmental Sciences Division in the Office of
Biological and Environmental Research, Office of Science, U.S.
Department of Energy, Grants Dr-FG02-08ER64567 and
ER65222-1038426-0017532. Portions of this research were supported
through a Cooperative Agreement (DEFC09-07-SR22506) between the
Department of Energy and the University of Georgia Research Foundation.
Although EPA contributed to this article, the research presented was not
performed or funded by EPA and was not subject to EPA's quality system
requirements. Consequently, the views, interpretations, and conclusions
expressed in this article are solely those of the authors and do not
necessarily reflect or represent EPA's views or policies. SEM-BSE-EDS
images were obtained at the Department of Geology, University of
Georgia. The XANES measurements were performed at the Canadian Light
Source, supported by the Natural Sciences and Engineering Research
Council of Canada, the National Research Council Canada, the Canadian
Institutes of Health Research, the Province of Saskatchewan, Western
Economic Diversification Canada, and the University of Saskatchewan.
NR 62
TC 9
Z9 10
U1 7
U2 53
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 19
PY 2014
VL 48
IS 16
BP 9270
EP 9278
DI 10.1021/es5015136
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AN6JW
UT WOS:000340701800041
PM 25051143
ER
PT J
AU Chowdhury, I
Duch, MC
Mansukhani, ND
Hersam, MC
Bouchard, D
AF Chowdhury, Indranil
Duch, Matthew C.
Mansukhani, Nikhita D.
Hersam, Mark C.
Bouchard, Dermont
TI Interactions of Graphene Oxide Nanomaterials with Natural Organic Matter
and Metal Oxide Surfaces
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID QUARTZ-CRYSTAL MICROBALANCE; FULLERENE C-60 NANOPARTICLES; AGGREGATION
KINETICS; HUMIC SUBSTANCES; PHOTOCATALYTIC REDUCTION; GRAPHITE OXIDE;
POROUS-MEDIA; STEM-CELLS; DEPOSITION; MECHANISMS
AB Interactions of graphene oxide (GO) nanomaterials with natural organic matter (NOM) and metal oxide surfaces were investigated using a quartz crystal microbalance with dissipation monitoring (QCM-D). Three different types of NOM were studied: Suwannee River humic and fulvic acids (SRHA and SRFA) and alginate. Aluminum oxide surface was used as a model metal oxide surface. Deposition trends show that GO has the highest attachment on alginate, followed by SRFA, SRHA, and aluminum oxide surfaces, and that GO displayed higher interactions with all investigated surfaces than with silica. Deposition and release behavior of GO on aluminum oxide surface is very similar to positively charged poly-L-lysine-coated surface. Higher interactions of GO with NOM-coated surfaces are attributed to the hydroxyl, epoxy, and carboxyl functional groups of GO; higher deposition on alginate-coated surfaces is attributed to the rougher surface created by the extended conformation of the larger alginate macromolecules. Both ionic strength (IS) and ion valence (Na+ vs Ca2+) had notable impact on interactions of GO with different environmental surfaces. Due to charge screening, increased IS resulted in greater deposition for NOM-coated surfaces. Release behavior of deposited GO varied significantly between different environmental surfaces. All surfaces showed significant release of deposited GO upon introduction of low IS water, indicating that deposition of GO on these surfaces is reversible. Release of GO from NOM-coated surfaces decreased with IS due to charge screening. Release rates of deposited GO from alginate-coated surface were significantly lower than from SRHA and SRFA-coated surfaces due to trapping of GO within the rough surface of the alginate layer.
C1 [Chowdhury, Indranil] Natl Res Council Res Associate, Athens, GA 30605 USA.
[Duch, Matthew C.; Mansukhani, Nikhita D.; Hersam, Mark C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA.
[Duch, Matthew C.; Mansukhani, Nikhita D.; Hersam, Mark C.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA.
[Duch, Matthew C.; Mansukhani, Nikhita D.; Hersam, Mark C.] Northwestern Univ, Dept Med, Evanston, IL 60208 USA.
[Bouchard, Dermont] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
RP Bouchard, D (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
EM Bouchard.Dermont@epa.gov
RI Hersam, Mark/B-6739-2009; Mansukhani, Nikhita/H-2328-2016
OI Mansukhani, Nikhita/0000-0001-6002-0132
FU National Research Council (NRC) Research Associateship Award at EPA;
University of California Center for the Environmental Implications of
Nanotechnology (NSF-EPA) [DBI-1266377]
FX Funding was provided for Indranil Chowdhury by a National Research
Council (NRC) Research Associateship Award at EPA. Additional funding
was provided by the University of California Center for the
Environmental Implications of Nanotechnology (NSF-EPA under Cooperative
Agreement # DBI-1266377). This paper has been reviewed in accordance
with the USEPA's peer and administrative review policies and approved
for publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 61
TC 19
Z9 19
U1 24
U2 187
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 19
PY 2014
VL 48
IS 16
BP 9382
EP 9390
DI 10.1021/es5020828
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AN6JW
UT WOS:000340701800054
PM 25026416
ER
PT J
AU Laue, H
Gfeller, H
Jenner, KJ
Nichols, JW
Kern, S
Natsch, A
AF Laue, Heike
Gfeller, Hans
Jenner, Karen J.
Nichols, John W.
Kern, Susanne
Natsch, Andreas
TI Predicting the Bioconcentration of Fragrance Ingredients by Rainbow
Trout Using Measured Rates of in Vitro Intrinsic Clearance
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ORGANIC-CHEMICALS; ONCORHYNCHUS-MYKISS; ENZYME-ACTIVITIES;
BIOACCUMULATION ASSESSMENT; BIOTRANSFORMATION RATES; XENOBIOTIC
METABOLISM; S9 FRACTIONS; FISH; LIVER; HEPATOCYTES
AB Bioaccumulation in aquatic species is a critical end point in the regulatory assessment of chemicals. Few measured fish bioconcentration factors (BCFs) are available for fragrance ingredients. Thus, predictive models are often used to estimate their BCFs. Because biotransformation can reduce chemical accumulation in fish, models using QSAR-estimated biotransformation rates have been developed. Alternatively, biotransformation can be measured by in vitro methods. In this study, biotransformation rates for nine fragrance ingredients were measured using trout liver S9 fractions and used as inputs to a recently refined in vitro-in vivo extrapolation (IVIVE) model. BCFs predicted by the model were then compared to (i) in vivo BCFs, (ii) BCFs predicted using QSAR-derived biotransformation rates, (iii) BCFs predicted without biotransformation, and (iv) BCFs predicted by a well-known regression model. For fragrance ingredients with relatively low (<4.7) log K-OW values, all models predicted BCFs below a bioaccumulation threshold of 1000. For chemicals with higher (4.7-5.8) log K-OW values, the model incorporating measured in vitro biotransformation rates and assuming no correction for potential binding effects on hepatic clearance provided the most accurate predictions of measured BCFs. This study demonstrates the value of integrating measured biotransformation rates for prediction of chemical bioaccumulation in fish.
C1 [Laue, Heike; Gfeller, Hans; Kern, Susanne; Natsch, Andreas] Givaudan Schweiz AG, Fragrances S&T, CH-8600 Dubendorf, Switzerland.
[Jenner, Karen J.] Givaudan UK Ltd, Global Regulatory Affairs & Prod Safety, Ashford TN24 OLT, Kent, England.
[Nichols, John W.] US EPA, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Laue, H (reprint author), Givaudan Schweiz AG, Fragrances S&T, CH-8600 Dubendorf, Switzerland.
EM heike.laue@givaudan.com
NR 39
TC 7
Z9 8
U1 3
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 19
PY 2014
VL 48
IS 16
BP 9486
EP 9495
DI 10.1021/es500904h
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AN6JW
UT WOS:000340701800066
PM 25058173
ER
PT J
AU Wiedinmyer, C
Yokelson, RJ
Gullett, BK
AF Wiedinmyer, Christine
Yokelson, Robert J.
Gullett, Brian K.
TI Global Emissions of Trace Gases, Particulate Matter, and Hazardous Air
Pollutants from Open Burning of Domestic Waste
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PCDD/PCDF EMISSIONS; INVENTORY; INVERSION; QUALITY
AB The open burning of waste, whether at individual residences, businesses, or dump sites, is a large source of air pollutants. These emissions, however, are not included in many current emission inventories used for chemistry and climate modeling applications. This paper presents the first comprehensive and consistent estimates of the global emissions of greenhouse gases, particulate matter, reactive trace gases, and toxic compounds from open waste burning. Global emissions of CO2 from open waste burning are relatively small compared to total anthropogenic CO2; however, regional CO2 emissions, particularly in many developing countries in Asia and Africa, are substantial. Further, emissions of reactive trace gases and particulate matter from open waste burning are more significant on regional scales. For example, the emissions of PM10 from open domestic waste burning in China is equivalent to 22% of China's total reported anthropogenic PM10 emissions. The results of the emissions model presented here suggest that emissions of many air pollutants are significantly underestimated in current inventories because open waste burning is not included, consistent with studies that compare model results with available observations.
C1 [Wiedinmyer, Christine] Natl Ctr Atmospher Res, Boulder, CO 80301 USA.
[Yokelson, Robert J.] Univ Montana, Dept Chem & Biochem, Missoula, MT 59812 USA.
[Gullett, Brian K.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Wiedinmyer, C (reprint author), Natl Ctr Atmospher Res, Boulder, CO 80301 USA.
EM christin@ucar.edu
RI Yokelson, Robert/C-9971-2011
OI Yokelson, Robert/0000-0002-8415-6808
FU National Science Foundation
FX The authors thank L. Emmons and R. Kumar for their thoughtful comments
on the manuscript. The National Center for Atmospheric Research is
operated by the University Corporation for Atmospheric Research under
the sponsorship of the National Science Foundation.
NR 27
TC 27
Z9 27
U1 8
U2 52
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 19
PY 2014
VL 48
IS 16
BP 9523
EP 9530
DI 10.1021/es502250z
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AN6JW
UT WOS:000340701800070
PM 25019173
ER
PT J
AU Schoen, ME
Xue, XB
Hawkins, TR
Ashbolt, NJ
AF Schoen, Mary E.
Xue, Xiaobo
Hawkins, Troy R.
Ashbolt, Nicholas J.
TI Comparative Human Health Risk Analysis of Coastal Community Water and
Waste Service Options
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ROOF-HARVESTED RAINWATER; DISINFECTION BY-PRODUCTS; DRINKING-WATER;
MICROBIAL RISKS; SOUTHEAST QUEENSLAND; CONTROLLED TRIAL; UNITED-STATES;
PATHOGENS; QUALITY; SEWAGE
AB As a pilot approach to describe adverse human health effects from alternative decentralized community water systems compared to conventional centralized services (business-as-usual [BAUD, selected chemical and microbial hazards were assessed using disability adjusted life years (DALYs) as the common metric. The alternatives included: (1) composting toilets with septic system, (2) urine-diverting toilets with septic system, (3) low flush toilets with blackwater pressure sewer and on-site greywater collection and treatment for nonpotable reuse, and (4) alternative 3 with on-site rainwater treatment and use. Various pathogens (viral, bacterial, and protozoan) and chemicals (disinfection byproducts [DBPs]) were used as reference hazards. The exposure pathways for BAU included accidental ingestion of contaminated recreational water, ingestion of cross-connected sewage to drinking water, and shower exposures to DBPs. The alternative systems included ingestion of treated greywater from garden irrigation, toilet flushing, and crop consumption; and ingestion of treated rainwater while showering. The pathways with the highest health impact included the ingestion of cross-connected drinking water and ingestion of recreational water contaminated by septic seepage. These were also among the most uncertain when characterizing input parameters, particularly the scale of the cross-connection event, and the removal of pathogens during groundwater transport of septic seepage. A comparison of the health burdens indicated potential health benefits by switching from BAU to decentralized water and wastewater systems.
C1 [Schoen, Mary E.] Soller Environm Inc, Berkeley, CA 94703 USA.
[Xue, Xiaobo] US EPA, Oak Ridge Inst Sci & Educ, Cincinnati, OH 45268 USA.
[Hawkins, Troy R.] US EPA, Cincinnati, OH 45268 USA.
[Ashbolt, Nicholas J.] Univ Alberta, Edmonton, AB T6G 2G7, Canada.
RP Schoen, ME (reprint author), 312 NE 82nd St, Seattle, WA 98115 USA.
EM mschoen@sollerenvironmental.com
FU U.S. Environmental Protection Agency Office of Research and Development
FX This project was supported by the U.S. Environmental Protection Agency
Office of Research and Development.
NR 52
TC 14
Z9 14
U1 1
U2 39
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 19
PY 2014
VL 48
IS 16
BP 9728
EP 9736
DI 10.1021/es501262p
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AN6JW
UT WOS:000340701800094
PM 24988142
ER
EF