FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Kerfoot, WC Urban, NR McDonald, CP Rossmann, R Zhang, HX AF Kerfoot, W. Charles Urban, Noel R. McDonald, Cory P. Rossmann, Ronald Zhang, Huanxin TI Legacy mercury releases during copper mining near Lake Superior SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Copper mining; Sediment cores; Mercury flux; Methylmercury; Keweenaw Peninsula; Lake Superior ID ATOMIC FLUORESCENCE SPECTROMETRY; DATED SEDIMENT CORES; KEWEENAW PENINSULA; MARINE-SEDIMENTS; HIGH-RESOLUTION; METHYL MERCURY; IMPACTED LAKE; MINE TAILINGS; PORTAGE LAKE; GREAT-LAKES AB To examine issues of mercury contamination in lake sediments and fish, we require insight into historic sources of mercury and details of watershed methyl mercury (MeHg) cycling. Modern-day National Atmospheric Deposition Program (NADP) estimates of atmospheric mercury deposition in the upper Midwest region range from 4-10 mu g/m(2)/y (wet only) to 5-30 mu g/m(2)/y (gross deposition). Sedimentary records from scattered Michigan lakes, removed from mining sites, record around 5-24 mu g/m(2)/y modern THg deposition. However, these values are not representative of historic deposition near mining sites. On the Keweenaw Peninsula, mercury occurs naturally in copper ores and was discharged by smelting and stamp mill (tailings) operations. Here we examine mercury fluxes into two lakes (Portage and Torch Lake, portions of the Keweenaw Waterway) off Lake Superior, part of the previous Torch Lake Superfund site. Total mercury fluxes document greatly enhanced mercury loading (mean ca. 1590 mu g/m(2)/y; peaks of 5120 to 21,300 mu g/m(2)/y) during the height of copper mining (1880-1930), followed by a rapid decline once activities ceased. Methylmercury profiles appear to document both current methylation and historic methylation during mining operations. Time differences in MeHg and THg profiles may relate to watershed delivery time lags, toxic effects of copper on methylating bacteria, or to stratigraphic mobility. Whereas rapid sedimentation and lowered copper flux are promoting ecosystem recovery in Portage Lake, slower burial by organic-rich sediments is enhancing metal concentrations in Torch Lake sediments. (C) 2015 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Kerfoot, W. Charles] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. [Kerfoot, W. Charles; Urban, Noel R.; McDonald, Cory P.] Michigan Technol Univ, Great Lakes Res Ctr, Houghton, MI 49931 USA. [Urban, Noel R.; McDonald, Cory P.] Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. [Rossmann, Ronald] US EPA, Midcontinent Ecol Div, Large Lakes Res Stn, Grosse Ile, MI 48138 USA. [Zhang, Huanxin] Michigan Technol Univ, Dept Geol & Min Engn & Sci, Houghton, MI 49931 USA. RP Kerfoot, WC (reprint author), Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA.; Kerfoot, WC (reprint author), Michigan Technol Univ, Great Lakes Res Ctr, Houghton, MI 49931 USA. EM wkerfoot@mtu.edu OI McDonald, Cory/0000-0002-1208-8471 FU Michigan Department of Environmental Quality (MDEQ) grant; NSF [OCE 97-12872]; U.S. Environmental Protection Agency FX This study was funded in part by a Michigan Department of Environmental Quality (MDEQ) grant (Long Term Monitoring Study, Torch Lake Superfund Site) with additional support from NSF OCE 97-12872 (NOAA/NSF KITES Project) to WCK and NRU. The information in this document, especially MeHg and THg analyses, also has been funded (in part) by the U.S. Environmental Protection Agency (Ronald Rossmann). Many of the ore samples analyzed came from the A. E. Seaman Mineral Museum, Michigan Tech University, where we thank George W. Robinson for assistance. The authors gratefully acknowledge the help of Cory Larsen, Justin Massie, and Eric Sajtar with sample preparation and analysis. This is contribution number 28 of the Great Lakes Research Center at Michigan Tech. NR 96 TC 1 Z9 1 U1 10 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD FEB PY 2016 VL 42 IS 1 BP 50 EP 61 DI 10.1016/j.jglr.2015.10.007 PG 12 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DD7PB UT WOS:000370115500006 ER PT J AU Zhang, XM Rygwelski, KR Rowe, MD Rossmann, R Kreis, RG AF Zhang, Xiaomi Rygwelski, Kenneth R. Rowe, Mark D. Rossmann, Ronald Kreis, Russell G., Jr. TI Global and regional contributions to total mercury concentrations in Lake Michigan water SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Mercury; Lake Michigan; Mass balance model; Model forecasts; Global and regional contributions ID NATURAL SOURCES; GREAT-LAKES; DEPOSITION; BIOACCUMULATION; EMISSIONS; EXCHANGE; FATE AB The Lake Michigan mercury mass balance model, LM2-Mercury, which was calibrated to a comprehensive data set collected from Lake Michigan during 1994-1995, was applied to predict long-term total mercury concentrations in lake water for different mercury loading and air concentration scenarios. The model predictions (volume weighted, lakewide average total mercury concentrations) appear to be comparable to the available independent measurements from 2005 through 2013. The forecast based on the constant condition scenario, where conditions representative of 1994-1995 were held constant, shows that total mercury concentrations in the lake are near steady-state. The model was used to investigate the relative importance of different global versus regional impact scenarios on total mercury concentrations in Lake Michigan. The results suggest that mercury from global sources could contribute between 30% and 70% of total mercury water concentrations in Lake Michigan. Results for declining global emission scenarios modeled, based on both high and low global contribution estimates and information on mercury emission trends from current observations and the literature, indicate that total mercury concentrations in the water column in Lake Michigan will continue to decrease. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Zhang, Xiaomi] Trinity Engn Associates Inc, Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA. [Rygwelski, Kenneth R.; Rowe, Mark D.; Kreis, Russell G., Jr.] US EPA, Natl Hlth & Environm Effects Res Lab, Large Lakes & Rivers Forecasting Res Branch, Off Res & Dev,Midcontinent Ecol Div,Large Lakes R, 9311 Groh Rd, Grosse Ile, MI 48138 USA. [Rowe, Mark D.] Univ Michigan, CILER, 4840 S State Rd, Ann Arbor, MI 48108 USA. [Rossmann, Ronald] Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA. RP Rygwelski, KR (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Large Lakes & Rivers Forecasting Res Branch, Off Res & Dev,Midcontinent Ecol Div,Large Lakes R, 9311 Groh Rd, Grosse Ile, MI 48138 USA. EM rygwelski.kenneth@epa.gov OI Rowe, Mark/0000-0002-0852-3346 FU U.S. Environmental Protection Agency FX This project was funded wholly by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. Special thanks go out to the agency personnel at the Large Lakes Research Station, Grosse Ile, Michigan for general support and technical direction; David Krabbenhoft and Alice Dove for personal communication of data; Dr. James Pauer for helpful comments; and anonymous Journal of Great Lakes Research technical reviewers. NR 30 TC 0 Z9 0 U1 2 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD FEB PY 2016 VL 42 IS 1 BP 62 EP 69 DI 10.1016/j.jgir.2015.10.010 PG 8 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DD7PB UT WOS:000370115500007 ER PT J AU Hill, RA Weber, MH Leibowitz, SG Olsen, AR Thornbrugh, DJ AF Hill, Ryan A. Weber, Marc H. Leibowitz, Scott G. Olsen, Anthony R. Thornbrugh, Darren J. TI THE STREAM-CATCHMENT (STREAMCAT) DATASET: A DATABASE OF WATERSHED METRICS FOR THE CONTERMINOUS UNITED STATES SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE streams; catchments; watersheds; watershed metrics; National Hydrography Dataset Plus; database; conterminous United States ID LANDSCAPES AB We developed an extensive database of landscape metrics for similar to 2.65 million stream segments, and their associated catchments, within the conterminous United States (U.S.): The Stream-Catchment (StreamCat) Dataset. These data are publically available (http://www2.epa.gov/national-aquatic-resource-surveys/streamcat) and greatly reduce the specialized geospatial expertise needed by researchers and managers to acquire landscape information for both catchments (i.e., the nearby landscape flowing directly into streams) and full upstream watersheds of specific stream reaches. When combined with an existing geospatial framework of the Nation's rivers and streams (National Hydrography Dataset Plus Version 2), the distribution of catchment and watershed characteristics can be visualized for the conterminous U.S. In this article, we document the development and main features of this dataset, including the suite of landscape features that were used to develop the data, scripts and algorithms used to accumulate and produce watershed summaries of landscape features, and the quality assurance procedures used to ensure data consistency. The StreamCat Dataset provides an important tool for stream researchers and managers to understand and characterize the Nation's rivers and streams. C1 [Hill, Ryan A.; Weber, Marc H.; Leibowitz, Scott G.; Olsen, Anthony R.; Thornbrugh, Darren J.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. RP Hill, RA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM hill.ryan@epa.gov OI Weber, Marc/0000-0002-9742-4744 FU U.S. Environmental Protection Agency FX We thank James Falcone and David Wolock of the USGS for providing several landscape layers used to create the StreamCat Dataset. We also thank Cindy McKay of Horizon Systems Corporation (under contract to the EPA Office of Water) for her consultation and advice on use of NHDPlusV2. Comments by Cindy McKay, Richard Moore, Alan Rea, Tommy Dewald, James Markweise, Daren Carlisle, and three anonymous reviewers greatly improved the manuscript. The information in this document has been funded entirely by the U.S. Environmental Protection Agency, in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. This manuscript has been subjected to Agency review and has been approved for publication. The views expressed in this journal article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 29 TC 4 Z9 4 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD FEB PY 2016 VL 52 IS 1 BP 120 EP 128 DI 10.1111/1752-1688.12372 PG 9 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DD5XV UT WOS:000369999100008 ER PT J AU Voelker, SL Brooks, JR Meinzer, FC Anderson, R Bader, MKF Battipaglia, G Becklin, KM Beerling, D Bert, D Betancourt, JL Dawson, TE Domec, JC Guyette, RP Korner, C Leavitt, SW Linder, S Marshall, JD Mildner, M Ogee, J Panyushkina, I Plumpton, HJ Pregitzer, KS Saurer, M Smith, AR Siegwolf, RTW Stambaugh, MC Talhelm, AF Tardif, JC Van de Water, PK Ward, JK Wingate, L AF Voelker, Steven L. Brooks, J. Renee Meinzer, Frederick C. Anderson, Rebecca Bader, Martin K. -F. Battipaglia, Giovanna Becklin, Katie M. Beerling, David Bert, Didier Betancourt, Julio L. Dawson, Todd E. Domec, Jean-Christophe Guyette, Richard P. Koerner, Christian Leavitt, Steven W. Linder, Sune Marshall, John D. Mildner, Manuel Ogee, Jerome Panyushkina, Irina Plumpton, Heather J. Pregitzer, Kurt S. Saurer, Matthias Smith, Andrew R. Siegwolf, Rolf T. W. Stambaugh, Michael C. Talhelm, Alan F. Tardif, Jacques C. Van de Water, Peter K. Ward, Joy K. Wingate, Lisa TI A dynamic leaf gas-exchange strategy is conserved in woody plants under changing ambient CO2: evidence from carbon isotope discrimination in paleo and CO2 enrichment studies SO GLOBAL CHANGE BIOLOGY LA English DT Article DE angiosperm; carbon dioxide; free-air CO2 enrichment; gymnosperm; optimal stomatal behavior; photosynthesis; stomatal conductance; water use efficiency ID WATER-USE EFFICIENCY; VAPOR-PRESSURE DEFICIT; RING STABLE-ISOTOPES; LAST GLACIAL MAXIMUM; ANTARCTIC ICE CORE; FOREST FACE SITES; ELEVATED CO2; TREE-RINGS; ATMOSPHERIC CO2; MESOPHYLL CONDUCTANCE AB Rising atmospheric [CO2], c(a), is expected to affect stomatal regulation of leaf gas-exchange of woody plants, thus influencing energy fluxes as well as carbon (C), water, and nutrient cycling of forests. Researchers have proposed various strategies for stomatal regulation of leaf gas-exchange that include maintaining a constant leaf internal [CO2], c(i), a constant drawdown in CO2 (c(a)-c(i)), and a constant c(i)/c(a). These strategies can result in drastically different consequences for leaf gas-exchange. The accuracy of Earth systems models depends in part on assumptions about generalizable patterns in leaf gas-exchange responses to varying c(a). The concept of optimal stomatal behavior, exemplified by woody plants shifting along a continuum of these strategies, provides a unifying framework for understanding leaf gas-exchange responses to c(a). To assess leaf gas-exchange regulation strategies, we analyzed patterns in c(i) inferred from studies reporting C stable isotope ratios (C-13) or photosynthetic discrimination () in woody angiosperms and gymnosperms that grew across a range of c(a) spanning at least 100ppm. Our results suggest that much of the c(a)-induced changes in c(i)/c(a) occurred across c(a) spanning 200 to 400ppm. These patterns imply that c(a)-c(i) will eventually approach a constant level at high c(a) because assimilation rates will reach a maximum and stomatal conductance of each species should be constrained to some minimum level. These analyses are not consistent with canalization toward any single strategy, particularly maintaining a constant c(i). Rather, the results are consistent with the existence of a broadly conserved pattern of stomatal optimization in woody angiosperms and gymnosperms. This results in trees being profligate water users at low c(a), when additional water loss is small for each unit of C gain, and increasingly water-conservative at high c(a), when photosystems are saturated and water loss is large for each unit C gain. C1 [Voelker, Steven L.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [Brooks, J. Renee] US EPA, Western Ecol Div, NHEERL, 200 SW 35Th St, Corvallis, OR 97333 USA. [Meinzer, Frederick C.] USDA, Forest Serv, Pacific NW Res Stn, 3200 SW Jefferson Way, Corvallis, OR 97331 USA. [Anderson, Rebecca] Univ Calif Santa Cruz, Jack Baskin Engn, Santa Cruz, CA 95604 USA. [Bader, Martin K. -F.] New Zealand Forest Res Inst SCION, Te Papa Tipu Innovat Pk,20 Sala St, Rotorua 3046, New Zealand. [Battipaglia, Giovanna] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol DiS, I-81100 Caserta, Italy. [Battipaglia, Giovanna] Univ Montpellier 2, Ctr Bioarchaeol & Ecol, Ecole Prat Hautes Etud, Inst Bot, F-34090 Montpellier, France. [Becklin, Katie M.; Ward, Joy K.] Univ Kansas, Dept Ecol & Evolutionary Biol, 1200 Sunnyside Ave, Lawrence, KS 66045 USA. [Beerling, David] Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England. [Bert, Didier] INRA, BIOGECO UMR1202, F-33610 Cestas, France. [Bert, Didier] Univ Bordeaux, UMR BIOGECO 1202, F-33615 Pessac, France. [Betancourt, Julio L.] US Geol Survey, Natl Res Program, Water Mission Area, Mail Stop 430,12201 Sunrise Valley Dr, Reston, VA 20192 USA. [Dawson, Todd E.] Univ Calif Berkeley, Dept Integrat Biol, 1105 Valley Life Sci Bldg 3140, Berkeley, CA 94720 USA. [Domec, Jean-Christophe; Ogee, Jerome; Wingate, Lisa] INRA, Bordeaux Sci Agro, UMR ISPA 1391, F-33175 Gradignan, France. [Domec, Jean-Christophe] Duke Univ, Nicholas Sch Environm, Box 90328, Durham, NC 27708 USA. [Guyette, Richard P.; Stambaugh, Michael C.] Univ Missouri, Dept Forestry, 203 ABNR Bldg, Columbia, MO 65211 USA. [Koerner, Christian; Mildner, Manuel] Univ Basel, Inst Bot, Schonbeinstr 6, CH-4056 Basel, Switzerland. [Leavitt, Steven W.; Plumpton, Heather J.; Wingate, Lisa] INRA, ISPA UMR1391, F-33140 Villenave Dornon, France. [Linder, Sune; Panyushkina, Irina] Univ Arizona, Tree Ring Res Lab, 1215 E Lowell St, Tucson, AZ 85721 USA. [Marshall, John D.] Swedish Univ Agr Sci, Southern Swedish Forest Res Ctr, POB 49, SE-23053 Alnarp, Sweden. [Marshall, John D.] Swedish Univ Agr Sci, Dept Forest Ecol & Management, SE-90183 Umea, Sweden. [Pregitzer, Kurt S.; Talhelm, Alan F.] Univ Idaho, Dept Forest Rangeland & Fire Sci, 875 Perimeter Dr, Moscow, ID 83844 USA. [Saurer, Matthias; Siegwolf, Rolf T. W.] Paul Scherrer Inst, CH-5323 Villigen, Switzerland. [Smith, Andrew R.] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor LL57 2UW, Gwynedd, Wales. [Tardif, Jacques C.] Univ Winnipeg, C FIR, 515 Ave Portage, Winnipeg, MB R3B 2E9, Canada. [Van de Water, Peter K.] Calif State Univ Fresno, Dept Earth & Environm Sci, 2576 E San Ramon Ave,Mail Stop ST-24, Fresno, CA 93740 USA. RP Voelker, SL (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. EM dr.s.voelker@gmail.com RI Smith, Andy/A-7512-2011; Siegwolf, Rolf/D-4121-2009; Ogee, Jerome/C-7185-2013; Wingate, Lisa/G-5575-2015 OI Smith, Andy/0000-0001-8580-278X; Siegwolf, Rolf/0000-0002-0249-0651; Wingate, Lisa/0000-0003-1921-1556 FU National Science Foundation [DEB-0743882, AGS-1003601, NSF-EAR-1344703]; INRA EFPA Projet Innovant grant; French Research Agency [MACACC ANR-13-AGRO-0005, MARIS ANR-14-CE03-0007] FX We thank Dr. Jeff Warren, Dr. Jon Keeley, Dr. Jim Ehleringer and an anonymous reviewer for providing comments that greatly improved the manuscript and the many contributors who helped produce the data sets analyzed here. Research by S. Voelker was supported by the National Science Foundation grants DEB-0743882 and AGS-1003601. JCD, LW, JO and HJP acknowledge financial support from the INRA EFPA Projet Innovant (2012) grant awarded to LW and from the French Research Agency (projects MACACC ANR-13-AGRO-0005 and MARIS ANR-14-CE03-0007) and the National Science Foundation (NSF-EAR-1344703). We would also like to thank James Rolfe at the Godwin Laboratory at the University of Cambridge for his responsive analysis of the DUKE Face tree ring material. This manuscript has been subjected to the Environmental Protection Agency's peer and administrative review, and it has been approved for publication as an EPA document. It also underwent internal review and received formal approval by the U.S. Geological Survey. Mention of trade names or commercial products does not constitute endorsement or a recommendation for use. NR 106 TC 5 Z9 5 U1 19 U2 75 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1354-1013 EI 1365-2486 J9 GLOBAL CHANGE BIOL JI Glob. Change Biol. PD FEB PY 2016 VL 22 IS 2 BP 889 EP 902 DI 10.1111/gcb.13102 PG 14 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DC3RC UT WOS:000369135400032 PM 26391334 ER PT J AU Rhodes, ER Huff, EM Hamilton, DW Jones, JL AF Rhodes, Eric R. Huff, Emma M. Hamilton, Douglas W. Jones, Jenifer L. TI The evaluation of hollow-fiber ultrafiltration and celite concentration of enteroviruses, adenoviruses and bacteriophage from different water matrices SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Hollow-fiber ultrafiltration; Celite; Poliovirus; Adenovirus; Enteroviruses; Bacteriophage; Water concentration ID DEAD-END ULTRAFILTRATION; MULTIPLE MICROBE CLASSES; DRINKING-WATER; TAP WATER; SIMULTANEOUS RECOVERY; SURFACE-WATER; WASTE-WATER; SECONDARY CONCENTRATION; CRYPTOSPORIDIUM-PARVUM; 2ND-STEP CONCENTRATION AB The collection of waterborne pathogen occurrence data often requires the concentration of microbes from large volumes of water due to the low number of microorganisms that are typically present in environmental and drinking waters. Hollow-fiber ultrafiltration (HFUF) has shown promise in the recovery of various microorganisms. This study has demonstrated that the HFUF primary concentration method is effective at recovering bacteriophage phi X174, poliovirus, enterovirus 70, echovirus 7, coxsackievirus B4 and adenovirus 41 from large volumes of tap and river water with an average recovery of all viruses of 73.4% and 81.0%, respectively. This study also evaluated an effective secondary concentration method using celite for the recovery of bacteriophage and enteric viruses tested from HFUF concentrates of both matrices. Overall, the complete concentration method (HFUF primary concentration plus celite secondary concentration) resulted in a concentration factor of 3333 and average recoveries for all viruses from tap and river waters of 60.6% and 60.0%, respectively. Published by Elsevier B.V. C1 [Rhodes, Eric R.; Huff, Emma M.; Hamilton, Douglas W.; Jones, Jenifer L.] US EPA, Biohazard Assessment Res Branch, Microbiol & Chem Exposure, Assessment Res Div,Natl Exposure Res Lab,Off Res, 26 Martin Luther King Dr,MS-587, Cincinnati, OH 45268 USA. RP Rhodes, ER (reprint author), US EPA, Biohazard Assessment Res Branch, Microbiol & Chem Exposure, Assessment Res Div,Natl Exposure Res Lab,Off Res, 26 Martin Luther King Dr,MS-587, Cincinnati, OH 45268 USA. EM rhodes.eric@epa.gov NR 48 TC 3 Z9 3 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD FEB PY 2016 VL 228 BP 31 EP 38 DI 10.1016/j.jviromet.2015.11.003 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA DD1JY UT WOS:000369679200006 PM 26562058 ER PT J AU Moorhead, DL Sinsabaugh, RL Hill, BH Weintraub, MN AF Moorhead, Daryl L. Sinsabaugh, Robert L. Hill, Brian H. Weintraub, Michael N. TI Vector analysis of ecoenzyme activities reveal constraints on coupled C, N and P dynamics SO SOIL BIOLOGY & BIOCHEMISTRY LA English DT Article DE Extracellular enzymes; Stoichiometry; Vectors; Nutrients ID ENZYME-ACTIVITY; STOICHIOMETRY; SOIL; DEPOSITION; LIMITATION; EFFICIENCY; FOREST; RATIO; LEAF AB The primary goal of this study was to devise a quantitative method of interpreting the simultaneous microbial C, N, and P acquisition through the activities of four, key extracellular enzymes, 1,4-beta-glucosidase (BG), leucine aminopeptidase (LAP), 1,4-beta-N-acetylglucosaminidase (NAG) and acid/alkaline phosphatases (AP). To this end, the proportional activity of C vs. N acquiring enzymes (BG/[BG + NAG + LAP]) was plotted against C vs. P acquiring enzymes (BG/[BG + AP]). We then calculated the length and angle of the vector created by connecting a line between the plot origin and point represented by these proportions; the length quantifies relative C vs. nutrient limitation and the angle quantifies the relative P vs. N limitation. Analyses of large data sets obtained from soil, freshwater periphyton and aquatic sediments revealed that logarithmic, arcsine, arcsine-square-root and logit transformations did little to improve the statistical distribution of data over raw proportions. More importantly, the vector characteristics of enzyme activity loci are much easier to interpret for raw proportions than when data have been previously transformed. Analyses also revealed the importance of using consistent methods, i.e., omitting NAG assays for an acidic soil led to overestimates of P limitations, and the importance of understanding the nature of the system, i.e., soils of the Antarctic Dry Valleys had low BG activities, likely because there is little to no local production of cellulose. Further, analyses of four sites in Luquillo Forest, Puerto Rico, showed no differences among sites in relative C demand despite differences in BG activities, and higher P demand in the cloud than lower montane forest, despite higher AP activity at the latter site. Finally, analyses of three decomposing litter types over time revealed contrasting patterns of change in relative C, N and P demand over time, reflecting both stoichiometric and C quality effects on decomposer communities. Thus enzyme activity vectors reflect the simultaneous, relative resource demands of the microbial community independent of variations in total enzyme activity, such as may result from variations in total microbial biomass. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Moorhead, Daryl L.; Weintraub, Michael N.] Univ Toledo, Dept Environm Sci, 2801 W Bancroft St, Toledo, OH 43606 USA. [Sinsabaugh, Robert L.] Univ New Mexico, Dept Biol 1, Albuquerque, NM 87131 USA. [Hill, Brian H.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA. RP Moorhead, DL (reprint author), Univ Toledo, Dept Environm Sci, 2801 W Bancroft St, Toledo, OH 43606 USA. EM daryl.moorhead@utoledo.edu FU NSF Ecosystems Program grant [DEB-0918718] FX We thank Daniela F. Cusack for interpretation of the Luquillo data. DLM, MNW and RLS received support from the NSF Ecosystems Program grant DEB-0918718. NR 21 TC 2 Z9 2 U1 17 U2 54 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-0717 J9 SOIL BIOL BIOCHEM JI Soil Biol. Biochem. PD FEB PY 2016 VL 93 BP 1 EP 7 DI 10.1016/j.soilbio.2015.10.019 PG 7 WC Soil Science SC Agriculture GA DC4RE UT WOS:000369207200001 ER PT J AU Kreakie, BJ Hychka, KC Belaire, JA Minor, E Walker, HA AF Kreakie, B. J. Hychka, K. C. Belaire, J. A. Minor, E. Walker, H. A. TI Internet-Based Approaches to Building Stakeholder Networks for Conservation and Natural Resource Management SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Cybermetrics; Hyperlink; Relatedness; Social network analysis; Stakeholder ID WORLD-WIDE-WEB; SOCIAL NETWORKS; IMPLEMENTATION; ECOSYSTEMS; GOVERNANCE; GAP AB Social network analysis (SNA) is based on a conceptual network representation of social interactions and is an invaluable tool for conservation professionals to increase collaboration, improve information flow, and increase efficiency. We present two approaches to constructing internet-based social networks, and use an existing traditional (survey-based) case study to illustrate in a familiar context the deviations in methods and results. Internet-based approaches to SNA offer a means to overcome institutional hurdles to conducting survey-based SNA, provide unique insight into an institution's web presences, allow for easy snowballing (iterative process that incorporates new nodes in the network), and afford monitoring of social networks through time. The internet-based approaches differ in link definition: hyperlink is based on links on a website that redirect to a different website and relatedness links are based on a Google's "relatedness" operator that identifies pages "similar" to a URL. All networks were initiated with the same start nodes [members of a conservation alliance for the Calumet region around Chicago (n = 130)], but the resulting networks vary drastically from one another. Interpretation of the resulting networks is highly contingent upon how the links were defined. C1 [Kreakie, B. J.; Hychka, K. C.; Walker, H. A.] US Environm Protect Agcy, Atlantic Ecol Div, Off Res & Dev, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Belaire, J. A.] St Edwards Univ, 805 North Capital Texas Highway, Austin, TX 78746 USA. [Minor, E.] Univ Illinois, Dept Biol Sci, 845 W Taylor St, Chicago, IL 60607 USA. RP Kreakie, BJ (reprint author), US Environm Protect Agcy, Atlantic Ecol Div, Off Res & Dev, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM kreakie.betty@epa.gov FU EPA; DOE FX We would like to thank Dwaine Kreakie, Suzanne Ayvazian, Jason Grear, Jeff Hollister, Marilyn TenBrink, and the anonymous reviewers for their helpful comments during the development of this manuscript. This paper has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. This is contribution number ORD-008873 of the Atlantic Ecology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory. Mention of trade names or commercial products does not constitute endorsement or recommendation for use by the U.S. Government. Additionally, this research was not supported by in-kind funding, but was supported in part by an appointment to the ORISE participant research program supported by an interagency agreement between EPA and DOE. NR 36 TC 2 Z9 2 U1 3 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD FEB PY 2016 VL 57 IS 2 BP 345 EP 354 DI 10.1007/s00267-015-0624-8 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DB6PZ UT WOS:000368638500009 PM 26503113 ER PT J AU Daughton, CG AF Daughton, Christian G. TI In Response: Government perspective SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Editorial Material ID PHARMACEUTICALS; ENVIRONMENT; DRUGS; CARE C1 [Daughton, Christian G.] US EPA, Syst Exposure Div, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. RP Daughton, CG (reprint author), US EPA, Syst Exposure Div, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. NR 12 TC 1 Z9 1 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2016 VL 35 IS 2 BP 266 EP 268 DI 10.1002/etc.3210 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DC0DV UT WOS:000368888100003 PM 26808909 ER PT J AU Lu, J Struewing, I Vereen, E Kirby, AE Levy, K Moe, C Ashbolt, N AF Lu, J. Struewing, I. Vereen, E. Kirby, A. E. Levy, K. Moe, C. Ashbolt, N. TI Molecular Detection of Legionella spp. and their associations with Mycobacterium spp., Pseudomonas aeruginosa and amoeba hosts in a drinking water distribution system SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE drinking water distribution system; free living amoeba; indicator; Legionella; qPCR; waterborne pathogens ID MICROBIAL RISK-ASSESSMENT; FREE-LIVING PROTOZOA; COOLING-TOWER WATER; TAP WATER; ACANTHAMOEBA-POLYPHAGA; HARTMANNELLA-VERMIFORMIS; ENVIRONMENTAL-SAMPLES; SIMULTANEOUS RECOVERY; NAEGLERIA-FOWLERI; QUANTITATIVE PCR AB AimsThis study investigated waterborne opportunistic pathogens (OPs) including potential hosts, and evaluated the use of Legionella spp. for indicating microbial water quality for OPs within a full-scale operating drinking water distribution system (DWDS). Methods and ResultsTo investigate the occurrence of specific microbial pathogens within a major city DWDS we examined large volume (90l drinking water) ultrafiltration (UF) concentrates collected from six sites between February, 2012 and June, 2013. The detection frequency and concentration estimates by qPCR were: Legionella spp. (57%/85 cell equivalent, CEl(-1)), Mycobacterium spp. (88%/324CEl(-1)), Pseudomonas aeruginosa (24%/2CEl(-1)), Vermamoeba vermiformis (24%/2CEl(-1)) and Acanthamoeba spp. (42%/5 cyst equivalent, CEl(-1)). There was no detection of the following microorganisms: human faecal indicator Bacteroides (HF183), Salmonella enterica, Campylobacter spp., Escherichia coli O157:H7, Giardia intestinalis, Cryptosporidium spp. or Naegleria fowleri. There were significant correlations between the qPCR signals of Legionella spp. and Mycobacterium spp., and their potential hosts V.vermiformis and Acanthamoeba spp. Sequencing of Legionella spp. demonstrated limited diversity, with most sequences coming from two dominant groups, of which the larger dominant group was an unidentified species. Other known species including Legionella pneumophila were detected, but at low frequency. The densities of Legionella spp. and Mycobacterium spp. were generally higher (17 and 324 folds, respectively) for distal sites relative to the entry point to the DWDS. ConclusionsLegionella spp. occurred, had significant growth and were strongly associated with free-living amoebae (FLA) and Mycobacterium spp., suggesting that Legionella spp. could provide a useful DWDS monitoring role to indicate potential conditions for non-faecal OPs. Significance and Impact of the StudyThe results provide insight into microbial pathogen detection that may aid in the monitoring of microbial water quality within DWDS prior to customer exposures. C1 [Lu, J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Struewing, I.] CSS Dynamac, Cincinnati, OH USA. [Vereen, E.; Kirby, A. E.; Levy, K.; Moe, C.] Emory Univ, Ctr Global Safe Water Sanitat & Hyg, Atlanta, GA 30322 USA. [Ashbolt, N.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. RP Lu, J (reprint author), 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM lu.jingrang@epa.gov FU EPA ORD's Safe and Sustainable Water Resources Program; Water Research Foundation; United States Environmental Protection Agency through its Office of Research and Development FX This research was supported by EPA ORD's Safe and Sustainable Water Resources Program. This work has been made possible through funding from the Water Research Foundation. The information contained herein is based upon Intellectual Property that is jointly owned by Emory University Rollins School of Public Health and the Water Research Foundation. The Water Research Foundation and Emory University Rollins School of Public Health retain their rights to publish or produce the Jointly Owned Intellectual Property in part or in its entirety. Thanks to Sharon Yelton at Dynamac Inc. for assistance in some sample processing, and Vicente Gomez-Alvarez and Ann Grimm at EPA ORD for their valuable comments. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 60 TC 4 Z9 4 U1 18 U2 49 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD FEB PY 2016 VL 120 IS 2 BP 509 EP 521 DI 10.1111/jam.12996 PG 13 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA DB8UX UT WOS:000368793500025 PM 26535924 ER PT J AU Grabich, SC Horney, J Konrad, C Lobdell, DT AF Grabich, S. C. Horney, J. Konrad, C. Lobdell, D. T. TI Measuring the Storm: Methods of Quantifying Hurricane Exposure with Pregnancy Outcomes SO NATURAL HAZARDS REVIEW LA English DT Article DE Hurricanes; Natural disasters; Health hazards; Public health; Weather conditions; Climate change ID TROPICAL-CYCLONE INTENSITY; SIZE ESTIMATION ALGORITHMS; PRETERM DELIVERY; NATURAL DISASTER; BIRTH OUTCOMES; HEALTH; RISK; STRESS; SYSTEM; FETAL AB Increasing coastal populations and storm intensity may lead to more adverse health effects from tropical storms and hurricanes. Exposure during pregnancy can influence birth outcomes through mechanisms related to healthcare, infrastructure disruption, stress, nutrition, and injury. However, accurate estimation of health effects may be limited by nonspecific exposure definitions that create potential misclassification. The two predominant hurricane exposure assignments are (1) the county of a FEMA presidential disaster declaration; and (2) the specified area within a storm track. The authors propose a third method: meteorological severity of wind speed. Based on the Saffir-Simpson categories, wind speed was examined through binary and quartile comparisons. All three methods of exposure classification were compared by examining the associations with county-level preterm birth and low-birth-weight rates among Florida women who were pregnant during the 2004 hurricane season. The county-level environmental quality index developed by the EPA was used to control for county-level environmental factors. Although the models yielded unexpected negative results and insignificant rate differences, a descriptive and mapping analysis of the exposure methods showed clear heterogeneity of county exposure. (C) 2015 American Society of Civil Engineers. C1 [Grabich, S. C.; Horney, J.] Univ N Carolina, Gillings Sch Global Publ Hlth, 170 Rosenau Hall,CB 7400,135 Dauer Dr, Chapel Hill, NC 27599 USA. [Konrad, C.] Univ N Carolina, Dept Geog, Saunders Hall,Campus Box 3220, Chapel Hill, NC 27599 USA. [Lobdell, D. T.] US EPA, Natl Hlth & Environm Effects Res Lab, MD 58A, Res Triangle Pk, NC 27711 USA. RP Grabich, SC (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, 170 Rosenau Hall,CB 7400,135 Dauer Dr, Chapel Hill, NC 27599 USA. EM sgrabich@email.unc.edu; horney@sph.tamhsc.edu; cek@email.unc.edu; lobdell.danelle@epa.gov NR 30 TC 0 Z9 0 U1 4 U2 19 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1527-6988 EI 1527-6996 J9 NAT HAZARDS REV JI Nat. Hazards Rev. PD FEB PY 2016 VL 17 IS 1 AR 06015002 DI 10.1061/(ASCE)NH.1527-6996.0000204 PG 7 WC Engineering, Civil; Environmental Studies; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences; Water Resources GA DB9LK UT WOS:000368837300014 ER PT J AU Rogers, JM AF Rogers, J. M. TI Search for the missing lncs: gene regulatory networks in neural crest development and long non-coding RNA biomarkers of Hirschsprung's disease SO NEUROGASTROENTEROLOGY AND MOTILITY LA English DT Review DE enteric nervous system; megacolon; non-coding RNAs ID CELL-MIGRATION; NERVOUS-SYSTEM; COLON SEGMENTS; CODING RNA; PROLIFERATION; TRANSCRIPTOME; EXPRESSION; MODELS; HA117 AB Hirschsprung's disease (HSCR), a birth defect characterized by variable aganglionosis of the gut, affects about 1 in 5000 births and is a consequence of abnormal development of neural crest cells, from which enteric ganglia derive. In the companion article in this issue (Shen etal., Neurogasterenterol Motil 28: 266-73), the authors search for long non-coding RNAs (lncRNAs) differentially expressed in bowel tissues of infants with HSCR. Microarray analysis of over 37000 lncRNAs and 34000 mRNAs was done. The key result was identification of a set of 5 lncRNAs that is a potential diagnostic biomarker of HSCR. In this minireview, I provide an overview of neural crest development and the gene regulatory networks involved in specification, epithelial-mesenchymal transition, and migration of neural crest cells. Genes involved in later development, proliferation, and differentiation of neural crest cells as they migrate into the gut are also reviewed. Many of these genes are associated with HSCR, including RET, GDNF, GFR, EDN3, and EDNRB. LncRNAs and their roles in development and disease and their use as biomarkers are discussed. The authors of the companion article previously used a multipronged approach to elucidate the etiology of HSCR by examining the effects of specific miRNAs or lncRNAs and target genes on cell migration, proliferation, cell cycle, and apoptosis invitro. These studies are discussed in terms of their elegance and limitations. The companion article identifies many new lncRNAs that, in addition to providing potential biomarkers of HSCR, may be a treasure trove for future investigations. C1 [Rogers, J. M.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, B105-04, Res Triangle Pk, NC 27711 USA. RP Rogers, JM (reprint author), US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, B105-04, Res Triangle Pk, NC 27711 USA. EM rogers.john@epa.gov NR 27 TC 0 Z9 1 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1350-1925 EI 1365-2982 J9 NEUROGASTROENT MOTIL JI Neurogastroenterol. Motil. PD FEB PY 2016 VL 28 IS 2 BP 161 EP 166 DI 10.1111/nmo.12776 PG 6 WC Gastroenterology & Hepatology; Clinical Neurology; Neurosciences SC Gastroenterology & Hepatology; Neurosciences & Neurology GA DB9EB UT WOS:000368818100001 PM 26806097 ER PT J AU Abokifa, AA Yang, YJ Lo, CS Biswas, P AF Abokifa, Ahmed A. Yang, Y. Jeffrey Lo, Cynthia S. Biswas, Pratim TI Water quality modeling in the dead end sections of drinking water distribution networks SO WATER RESEARCH LA English DT Article DE Chlorine; Dead end pipe; Advection dispersion; Genetic algorithm; Stochastic demands; Spatial distribution; Correction factors ID CHLORINE CONCENTRATION DECAY; DISTRIBUTION-SYSTEMS; CONSTITUENT TRANSPORT; PIPES; SIMULATION; DEMANDS; FLOWS AB Dead-end sections of drinking water distribution networks are known to be problematic zones in terms of water quality degradation. Extended residence time due to water stagnation leads to rapid reduction of disinfectant residuals allowing the regrowth of microbial pathogens. Water quality models developed so far apply spatial aggregation and temporal averaging techniques for hydraulic parameters by assigning hourly averaged water demands to the main nodes of the network. Although this practice has generally resulted in minimal loss of accuracy for the predicted disinfectant concentrations in main water transmission lines, this is not the case for the peripheries of the distribution network. This study proposes a new approach for simulating disinfectant residuals in dead end pipes while accounting for both spatial and temporal variability in hydraulic and transport parameters. A stochastic demand generator was developed to represent residential water pulses based on a non-homogenous Poisson process. Dispersive solute transport was considered using highly dynamic dispersion rates. A genetic algorithm was used to calibrate the axial hydraulic profile of the dead-end pipe based on the different demand shares of the withdrawal nodes. A parametric sensitivity analysis was done to assess the model performance under variation of different simulation parameters. A group of Monte-Carlo ensembles was carried out to investigate the influence of spatial and temporal variations in flow demands on the simulation accuracy. A set of three correction factors were analytically derived to adjust residence time, dispersion rate and wall demand to overcome simulation error caused by spatial aggregation approximation. The current model results show better agreement with field-measured concentrations of conservative fluoride tracer and free chlorine disinfectant than the simulations of recent advection dispersion reaction models published in the literature. Accuracy of the simulated concentration profiles showed significant dependence on the spatial distribution of the flow demands compared to temporal variation. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Abokifa, Ahmed A.; Lo, Cynthia S.; Biswas, Pratim] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Biswas, P (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. EM ahmed.abokifa@wustl.edu; yang.jeff@epa.gov; clo@wustl.edu; pbiswas@wustl.edu RI Lo, Cynthia/B-5441-2008 OI Lo, Cynthia/0000-0003-2873-4869 FU U.S. EPA through the CBI [EP-C-4-014] FX This work was partially funded by U.S. EPA through the CB&I Contract EP-C-4-014. The research described herein has been subjected to the Agency's peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. The authors would like to thank Dr. Ravindra Gudi for providing valuable comments on the article. NR 38 TC 3 Z9 3 U1 13 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD FEB 1 PY 2016 VL 89 BP 107 EP 117 DI 10.1016/j.watres.2015.11.025 PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DC1BE UT WOS:000368951000011 PM 26641015 ER PT J AU Masih, A Taneja, A Singhvi, R AF Masih, Amit Taneja, Ajay Singhvi, Raj TI Exposure profiles of mercury in human hair at a terai belt of North India SO ENVIRONMENTAL GEOCHEMISTRY AND HEALTH LA English DT Article DE Hair Hg levels; Fish consumption; Terai belt; Atomic absorption spectrometry ID SEYCHELLES CHILD-DEVELOPMENT; FLUORESCENT LAMPS CFLS; FRESH-WATER FISH; METHYLMERCURY EXPOSURE; METALLIC MERCURY; METHYL-MERCURY; CONSUMPTION; HEALTH; CONTAMINATION; POLLUTION AB Human hair is frequently used as a bioindicator of mercury exposure. Mercury (Hg) has for centuries been a useful metal in a variety of applications. Unfortunately, this usefulness is counterbalanced by its neurotoxicological health impact. The US Environmental Protection Agency recommends keeping the hair Hg level < 1.0 A mu g/g. Therefore, an investigation has been performed in order to ascertain the hair Hg levels among the people living at the terai belt of North India. Hair samples were collected from 111 individuals and were placed in an identified plastic bag, stapled to prevent the shift of the hair strand. Samples were analyzed by combustion, gold amalgamation, atomic absorption spectrometry (C-GA-AAS). The mean Hg level in hair was 0.28 A mu g/g for the whole group ranging from 0.0012 to 1.9091 A mu g/g. The mean hair Hg levels were 0.16 A mu g/g for men and 0.12 A mu g/g for women, indicating that men had higher hair Hg levels than women. Total hair Hg was found to be significantly associated with age, gender and fish consumption frequency. 98 % of the total sample had hair Hg concentrations less than 1.0 A mu g/g, i.e, within safe dose, whereas only 2 % had Hg concentrations greater than 1.0 A mu g/g, thereby exceeding the safe dose. C1 [Masih, Amit] St Andrews Coll, Dept Chem, Environm Res Lab, Gorakhpur, Uttar Pradesh, India. [Taneja, Ajay] Dr Bhim Rao Ambedkar Univ, Dept Chem, Agra, Uttar Pradesh, India. [Singhvi, Raj] US EPA, Environm Response Team, Edison, NJ USA. RP Masih, A (reprint author), St Andrews Coll, Dept Chem, Environm Res Lab, Gorakhpur, Uttar Pradesh, India. EM amitmasih10@yahoo.com FU Department of Science and Technology, Government of India [SR/FTP/ES-77/2013] FX Authors gratefully acknowledges Revd Prof J. K. Lal (Principal), St Andrew's College, Gorakhpur, UP, India, for providing necessary facilities and Jay Patel, ERT, USEPA for providing technical support during the analysis of hair samples. Financial support from Department of Science and Technology, Government of India, in Project No. SR/FTP/ES-77/2013 is duly acknowledged. NR 53 TC 3 Z9 3 U1 7 U2 26 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0269-4042 EI 1573-2983 J9 ENVIRON GEOCHEM HLTH JI Environ. Geochem. Health PD FEB PY 2016 VL 38 IS 1 BP 145 EP 156 DI 10.1007/s10653-015-9698-8 PG 12 WC Engineering, Environmental; Environmental Sciences; Public, Environmental & Occupational Health; Water Resources SC Engineering; Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Water Resources GA DB7HJ UT WOS:000368685100012 PM 25837822 ER PT J AU McGuinn, LA Ward-Caviness, CK Neas, LM Schneider, A Diaz-Sanchez, D Cascio, WE Kraus, WE Hauser, E Dowdy, E Haynes, C Chudnovsky, A Koutrakis, P Devlin, RB AF McGuinn, Laura A. Ward-Caviness, Cavin K. Neas, Lucas M. Schneider, Alexandra Diaz-Sanchez, David Cascio, Wayne E. Kraus, William E. Hauser, Elizabeth Dowdy, Elaine Haynes, Carol Chudnovsky, Alexandra Koutrakis, Petros Devlin, Robert B. TI Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease SO ENVIRONMENTAL RESEARCH LA English DT Article DE Coronary disease; Epidemiology; Myocardial infarction; PM2.5; Spatiotemporal analyses ID PARTICULATE AIR-POLLUTION; AEROSOL OPTICAL DEPTH; BODY-MASS INDEX; UNITED-STATES; SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; TOTAL MORTALITY; AMBIENT PM2.5; RISK-FACTOR AB Background: Epidemiological studies have identified associations between long-term PM2.5 exposure and cardiovascular events, though most have relied on concentrations from central-site air quality monitors. Methods: We utilized a cohort of 5679 patients who had undergone cardiac catheterization at Duke University between 2002-2009 and resided in North Carolina. We used estimates of daily PM2.5 concentrations for North Carolina during the study period based on satellite derived Aerosol Optical Depth (AOD) measurements and PM2.5 concentrations from ground monitors, which were spatially resolved with a 10 x 10 km resolution, matched to each patient's residential address and averaged for the year prior to catheterization. The Coronary Artery Disease (CAD) index was used to measure severity of CAD; scores > 23 represent a hemodynamically significant coronary artery lesion in at least one major coronary vessel. Logistic regression modeled odds of having CAD or an MI with each 1 mu g/m(3) increase in annual average PM2.5, adjusting for sex, race, smoking status and socioeconomic status. Results: In adjusted models, a 1 mu g/m(3) increase in annual average PM2.5 was associated with an 11.1% relative increase in the odds of significant CAD (95% CI: 4.0-18.6%) and a 14.2% increase in the odds of having a myocardial infarction (MI) within a year prior (95% CI: 3.7-25.8%). Conclusions: Satellite-based estimates of long-term PM2.5 exposure were associated with both coronary artery disease (CAD) and incidence of myocardial infarction (MI) in a cohort of cardiac catheterization patients. (C) 2015 Elsevier Inc. All rights reserved. C1 [McGuinn, Laura A.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Ward-Caviness, Cavin K.; Schneider, Alexandra] Inst Epidemiol II, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany. [Neas, Lucas M.; Diaz-Sanchez, David; Cascio, Wayne E.; Devlin, Robert B.] US EPA, RTP, Res Triangle Pk, NC 27711 USA. [Kraus, William E.; Hauser, Elizabeth; Dowdy, Elaine; Haynes, Carol] Duke Univ, Sch Med, Durham, NC USA. [Chudnovsky, Alexandra; Koutrakis, Petros] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Chudnovsky, Alexandra] Tel Aviv Univ, Dept Geog & Human Environm, IL-69978 Tel Aviv, Israel. RP Devlin, RB (reprint author), US EPA, Environm Publ Hlth Div MD58D, Res Triangle Pk, NC 27711 USA. EM devlin.robert@epa.gov RI Schneider, Alexandra/B-5347-2014 FU US EPA; Health Effects Institute [4946-RFPA10-3/14-7]; NIEHS [T32ES007018] FX This research was supported by intramural research funding by the US EPA.; The Health Effects Institute (Research Agreement #4946-RFPA10-3/14-7) and the NIEHS (award number T32ES007018) provided additional funding. NR 47 TC 6 Z9 6 U1 7 U2 29 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD FEB PY 2016 VL 145 BP 9 EP 17 DI 10.1016/j.envres.2015.10.026 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DB0SV UT WOS:000368218700002 PM 26613345 ER PT J AU Cogliano, VJ AF Cogliano, Vincent James TI Lack of data drives uncertainty in PCB health risk assessments SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE PCBs; Hazard classification; Toxicity value; Uncertainty; Cancer; Partitioning; Transformation; Bioaccumulation ID POLYCHLORINATED-BIPHENYLS PCBS; TOXIC EQUIVALENCY FACTORS; LIVER TUMORIGENESIS; RATS; CARCINOGENICITY; 3,3'-DICHLOROBIPHENYL; INDUCTION; TUMORS AB Health risk assessments generally involve many extrapolations: for example, from animals to humans or from high doses to lower doses. Health risk assessments for PCBs involve all the usual uncertainties, plus additional uncertainties due to the nature of PCBs as a dynamic, complex mixture. Environmental processes alter PCB mixtures after release into the environment, so that people are exposed to mixtures that might not resemble the mixtures where there are toxicity data. This paper discusses the evolution of understanding in assessments of the cancer and noncancer effects of PCBs. It identifies where a lack of data in the past contributed to significant uncertainty and where new data subsequently altered the prevailing understanding of the toxicity of PCB mixtures, either qualitatively or quantitatively. Finally, the paper identifies some uncertainties remaining for current PCB health assessments, particularly those that result from a lack of data on exposure through nursing or on effects from inhalation of PCBs. C1 [Cogliano, Vincent James] US EPA, Washington, DC 20460 USA. RP Cogliano, VJ (reprint author), US EPA, 1200 Penn Ave NW 8601P, Washington, DC 20460 USA. EM cogliano.vincent@epa.gov NR 34 TC 0 Z9 0 U1 4 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD FEB PY 2016 VL 23 IS 3 BP 2212 EP 2219 DI 10.1007/s11356-015-5157-4 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DB2YO UT WOS:000368376800024 PM 26347413 ER PT J AU Ridoutt, BG Pfister, S Manzardo, A Bare, J Boulay, AM Cherubini, F Fantke, P Frischknecht, R Hauschild, M Henderson, A Jolliet, O Levasseur, A Margni, M McKone, T Michelsen, O Canals, LMI Page, G Pant, R Raugei, M Sala, S Verones, F AF Ridoutt, Bradley G. Pfister, Stephan Manzardo, Alessandro Bare, Jane Boulay, Anne-Marie Cherubini, Francesco Fantke, Peter Frischknecht, Rolf Hauschild, Michael Henderson, Andrew Jolliet, Olivier Levasseur, Annie Margni, Manuele McKone, Thomas Michelsen, Ottar Mila i Canals, Llorenc Page, Girija Pant, Rana Raugei, Marco Sala, Serenella Verones, Francesca TI Area of concern: a new paradigm in life cycle assessment for the development of footprint metrics SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT LA English DT Article DE Area of protection; Environmental footprint; Environmental labels and declarations; Footprint definition; Footprint indicator; ISO 14044; Life cycle impact assessment; UNEP/SETAC Life Cycle Initiative ID IMPACT ASSESSMENT; INDICATORS; RETHINKING; PROTECTION; FRAMEWORK; LCA AB Purpose As a class of environmental metrics, footprints have been poorly defined, have shared an unclear relationship to life cycle assessment (LCA), and the variety of approaches to quantification have sometimes resulted in confusing and contradictory messages in the marketplace. In response, a task force operating under the auspices of the UNEP/SETAC Life Cycle Initiative project on environmental life cycle impact assessment (LCIA) has been working to develop generic guidance for developers of footprint metrics. The purpose of this paper is to introduce a universal footprint definition and related terminology as well as to discuss modelling implications. Methods The task force has worked from the perspective that footprints should be based on LCA methodology, underpinned by the same data systems and models as used in LCA. However, there are important differences in purpose and orientation relative to LCA impact category indicators. Footprints have a primary orientation toward society and nontechnical stakeholders. They are also typically of narrow scope, having the purpose of reporting only in relation to specific topics. In comparison, LCA has a primary orientation toward stakeholders interested in comprehensive evaluation of overall environmental performance and trade-offs among impact categories. These differences create tension between footprints, the existing LCIA framework based on the area of protection paradigm and the core LCA standards ISO14040/44. Results and discussion In parallel to area of protection, we introduce area of concern as the basis for a universal footprint definition. In the same way that LCA uses impact category indicators to assess impacts that follow a common cause-effect pathway toward areas of protection, footprint metrics address areas of concern. The critical difference is that areas of concern are defined by the interests of stakeholders in society rather than the LCA community. In addition, areas of concern are stand-alone and not necessarily part of a framework intended for comprehensive environmental performance assessment. The area of concern paradigm is needed to support the development of footprints in a way that fulfils their distinctly different purpose. It is also needed as a mechanism to extricate footprints from some of the provisions of ISO 14040/44 which are not considered relevant. Specific issues are identified in relation to double counting, aggregation and the selection of relevant indicators. Conclusions The universal footprint definition and related terminology introduced in this paper create a foundation that will support the development of footprint metrics in parallel with LCA. C1 [Ridoutt, Bradley G.] CSIRO, Private Bag 10, Clayton, Vic 3169, Australia. [Ridoutt, Bradley G.] Univ Free State, Dept Agr Econ, ZA-9300 Bloemfontein, South Africa. [Ridoutt, Bradley G.] ETH, Inst Environm Engn, CH-8093 Zurich, Switzerland. [Manzardo, Alessandro] Univ Padua, Ctr Studi Qualita Ambiente, Dipartimento Ingn Ind, I-35131 Padua, Italy. [Bare, Jane; Henderson, Andrew] Natl Risk Management Res Lab, Syst Anal Branch, Sustainable Technol Div, United States Environm Protect Agcy, Cincinnati, OH 45268 USA. [Boulay, Anne-Marie; Levasseur, Annie; Margni, Manuele] Polytech Montreal, CIRAIG, Montreal, PQ, Canada. [Cherubini, Francesco; Verones, Francesca] Norwegian Univ Sci & Technol NTNU, Dept Energy & Proc Engn, Ind Ecol Programme, NO-7491 Trondheim, Norway. [Fantke, Peter; Hauschild, Michael] Tech Univ Denmark, Div Quantitat Sustainabil Assessment, Dept Engn Management, DK-2800 Lyngby, Denmark. [Frischknecht, Rolf] Treeze Ltd, Uster, Switzerland. [Jolliet, Olivier] Univ Michigan, Sch Publ Hlth Environm Hlth Sci, Ann Arbor, MI 48109 USA. [McKone, Thomas] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [McKone, Thomas] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Michelsen, Ottar] Norwegian Univ Sci & Technol, NTNU Sustainabil, N-7491 Trondheim, Norway. [Mila i Canals, Llorenc] Div Technol Ind & Econ, UNEP, 15 Rue Milan, F-75009 Paris, France. [Page, Girija] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia. [Pant, Rana; Sala, Serenella] Inst Environm & Sustainabil, European Commiss, Joint Res Ctr, Via Enrico Fermi 2749, I-21027 Ispra, Italy. [Raugei, Marco] Oxford Brookes Univ, Dept Mech Engn & Math Sci, Oxford OX33 1HX, England. RP Ridoutt, BG (reprint author), CSIRO, Private Bag 10, Clayton, Vic 3169, Australia.; Ridoutt, BG (reprint author), Univ Free State, Dept Agr Econ, ZA-9300 Bloemfontein, South Africa. EM Brad.Ridoutt@csiro.au RI Ridoutt, Bradley/D-3329-2011; Raugei, Marco/N-4737-2015; Pfister, Stephan/B-1317-2011; OI Ridoutt, Bradley/0000-0001-7352-0427; Sala, Serenella/0000-0003-1919-9948; Hauschild, Michael Zwicky/0000-0002-8331-7390; Raugei, Marco/0000-0001-5026-8556; Pfister, Stephan/0000-0001-8984-2041; Fantke, Peter/0000-0001-7148-6982 FU United Nations Environment Programme (UNEP)/Society of Environmental Toxicology and Chemistry (SETAC) Life Cycle Initiative FX This work is supported by the United Nations Environment Programme (UNEP)/Society of Environmental Toxicology and Chemistry (SETAC) Life Cycle Initiative. Public and private sector sponsors are listed on the Initiative's website (http://www.lifecycleinitiative.org/). The views expressed in this article are those of the authors and do not necessarily reflect those of the various affiliated organisations. NR 19 TC 5 Z9 5 U1 3 U2 17 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0948-3349 EI 1614-7502 J9 INT J LIFE CYCLE ASS JI Int. J. Life Cycle Assess. PD FEB PY 2016 VL 21 IS 2 BP 276 EP 280 DI 10.1007/s11367-015-1011-7 PG 5 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DB7XX UT WOS:000368731900012 ER PT J AU Rasmussen, K Gonzalez, M Kearns, P Sintes, JR Rossi, F Sayre, P AF Rasmussen, Kirsten Gonzalez, Mar Kearns, Peter Sintes, Juan Riego Rossi, Francois Sayre, Phil TI Review of achievements of the OECD Working Party on Manufactured Nanomaterials' Testing and Assessment Programme. From exploratory testing to test guidelines SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Review DE Manufactured nanomaterials; OECD WPMN testing programme; OECD test guidelines; Working Party on Manufactured; Nanomaterials; Regulatory testing ID TITANIUM-DIOXIDE NANOPARTICLES; IN-VITRO DOSIMETRY; ENGINEERED NANOMATERIALS; ENVIRONMENTAL FATE; CARBON NANOTUBES; AMORPHOUS SILICA; PARTICLE-SIZE; GENOTOXICITY; TOXICITY; CYTOTOXICITY AB This paper charts the almost ten years of history of OECD's work on nanosafety, during which the programme of the OECD on the Testing and Assessment of Manufactured Nanomaterials covered the testing of eleven nanomaterials for about 59 end-points addressing physical-chemical properties, mammalian and environmental toxicity, environmental fate and material safety. An overview of the materials tested, the test methods applied and the discussions regarding the applicability of the OECD test guidelines, which are recognised methods for regulatory testing of chemicals, are given. The results indicate that many existing OECD test guidelines are suitable for nanomaterials and consequently, hazard data collected using such guidelines will fall under OECD's system of Mutual Acceptance of Data (MAD) which is a legally binding instrument to facilitate the international acceptance of information for the regulatory safety assessment of chemicals. At the same time, some OECD test guidelines and guidance documents need to be adapted to address nanomaterials while new test guidelines and guidance documents may be needed to address endpoints that are more relevant to nanomaterials. This paper presents examples of areas where test guidelines or guidance for nanomaterials are under development. (C) 2015 The Authors. Published by Elsevier Inc. C1 [Rasmussen, Kirsten; Sintes, Juan Riego; Rossi, Francois] Commiss European Communities, Inst Hlth & Consumer Protect, Joint Res Ctr, Via E Fermi 2749, I-21027 Ispra, VA, Italy. [Gonzalez, Mar; Kearns, Peter] Environm Directorate, OECD, F-75775 Paris 16, France. [Sayre, Phil] US EPA, Washington, DC 20460 USA. RP Rasmussen, K (reprint author), Commiss European Communities, Inst Hlth & Consumer Protect, Joint Res Ctr, Via E Fermi 2749, I-21027 Ispra, VA, Italy. EM kirsten.rasmussen@ec.europa.eu; phil.sayre@verizon.net OI Kearns, Peter/0000-0001-7967-0274 NR 48 TC 4 Z9 4 U1 6 U2 25 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD FEB PY 2016 VL 74 BP 147 EP 160 DI 10.1016/j.yrtph.2015.11.004 PG 14 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA DB5LG UT WOS:000368555000017 PM 26603783 ER PT J AU Oliver, DM Hanley, ND van Niekerk, M Kay, D Heathwaite, AL Rabinovici, SJM Kinzelman, JL Fleming, LE Porter, J Shaikh, S Fish, R Chilton, S Hewitt, J Connolly, E Cummins, A Glenk, K McPhail, C McRory, E McVittie, A Giles, A Roberts, S Simpson, K Tinch, D Thairs, T Avery, LM Vinten, AJA Watts, BD Quilliam, RS AF Oliver, David M. Hanley, Nick D. van Niekerk, Melanie Kay, David Heathwaite, A. Louise Rabinovici, Sharyl J. M. Kinzelman, Julie L. Fleming, Lora E. Porter, Jonathan Shaikh, Sabina Fish, Rob Chilton, Sue Hewitt, Julie Connolly, Elaine Cummins, Andy Glenk, Klaus McPhail, Calum McRory, Eric McVittie, Alistair Giles, Amanna Roberts, Suzanne Simpson, Katherine Tinch, Dugald Thairs, Ted Avery, Lisa M. Vinten, Andy J. A. Watts, Bill D. Quilliam, Richard S. TI Molecular tools for bathing water assessment in Europe: Balancing social science research with a rapidly developing environmental science evidence-base SO AMBIO LA English DT Article DE Bathing Water Directive; Fecal indicator organism; Microbial pollution; Public perception; Recreational water quality; Risk communication ID QUALITY CRITERIA; COASTAL WATERS; BEACH; BENEFITS; LESSONS; ILLNESS; QPCR; COST AB The use of molecular tools, principally qPCR, versus traditional culture-based methods for quantifying microbial parameters (e.g., Fecal Indicator Organisms) in bathing waters generates considerable ongoing debate at the science-policy interface. Advances in science have allowed the development and application of molecular biological methods for rapid (similar to 2 h) quantification of microbial pollution in bathing and recreational waters. In contrast, culture-based methods can take between 18 and 96 h for sample processing. Thus, molecular tools offer an opportunity to provide a more meaningful statement of microbial risk to water-users by providing near-real-time information enabling potentially more informed decision-making with regard to water-based activities. However, complementary studies concerning the potential costs and benefits of adopting rapid methods as a regulatory tool are in short supply. We report on findings from an international Working Group that examined the breadth of social impacts, challenges, and research opportunities associated with the application of molecular tools to bathing water regulations. C1 [Oliver, David M.; van Niekerk, Melanie; Quilliam, Richard S.] Univ Stirling, Sch Nat Sci, Biol & Environm Sci, Stirling FK9 4LA, Scotland. [Hanley, Nick D.] Univ St Andrews, Dept Geog & Sustainable Dev, St Andrews KY16 9AL, Fife, Scotland. [Kay, David] Aberystwyth Univ, Ctr Res Environm & Hlth, Aberystwyth SA48 8HU, Dyfed, Wales. [Heathwaite, A. Louise] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England. [Kinzelman, Julie L.] City Racine Hlth Dept Lab, Racine, WI 53403 USA. [Fleming, Lora E.] Univ Exeter, Sch Med, European Ctr Environm & Human Hlth, Truro TR1 3HD, Cornwall, England. [Porter, Jonathan] Environm Agcy, Natl Lab Serv, Starcross EX6 8FD, Devon, England. [Shaikh, Sabina] Univ Chicago, Chicago, IL 60637 USA. [Fish, Rob] Univ Kent, Sch Anthropol & Conservat, Canterbury CT2 7NR, Kent, England. [Chilton, Sue] Newcastle Univ, Sch Business, Newcastle Upon Tyne NE1 4SE, Tyne & Wear, England. [Hewitt, Julie] US EPA, Econ & Environm Assessment Branch, Off Sci & Technol, Off Water, Washington, DC 20460 USA. [Connolly, Elaine] Dept Environm Food & Rural Affairs, London SW1P 3JR, England. [Cummins, Andy] Surfers Sewage, St Agnes TR5 0RD, Cornwall, England. [Glenk, Klaus; McVittie, Alistair] Scotlands Rural Coll SRUC, Land Econ Environm & Soc, Edinburgh EH9 3JG, Midlothian, Scotland. [McPhail, Calum] Scottish Environm Protect Agcy, Eurocentral ML1 4WQ, North Lanarkshi, England. [McRory, Eric] Scottish Environm Protect Agcy, Stirling FK9 4TZ, Scotland. [Giles, Amanna] Environm Agcy, Bristol BS1 5AH, Avon, England. [Roberts, Suzanne] Keep Scotland Beautiful, Stirling FK9 4TZ, Scotland. [Simpson, Katherine] Univ Stirling, Stirling Management Sch, Econ, Stirling FK9 4LA, Scotland. [Tinch, Dugald] Univ Tasmania, Sch Econ & Finance, Hobart, Tas, Australia. [Thairs, Ted] UK Water Ind Res Ltd, London SW1H 0RG, England. [Avery, Lisa M.] James Hutton Inst, Environm & Biochem Sci, Aberdeen AB15 8QH, Scotland. [Vinten, Andy J. A.] James Hutton Inst, Social Econ & Geog Sci, Aberdeen AB15 8QH, Scotland. [Watts, Bill D.] Brunel Univ, Inst Environm Hlth & Soc, London, England. RP Oliver, DM (reprint author), Univ Stirling, Sch Nat Sci, Biol & Environm Sci, Stirling FK9 4LA, Scotland. EM david.oliver@stir.ac.uk; ndh3@st-andrews.ac.uk; melvn233@gmail.com; dave@crehkay.demon.co.uk; louise.heathwaite@lancaster.ac.uk; sjmr12@yahoo.com; julie.kinzelman@cityofracine.org; lora.fleming@pcmd.ac.uk; jonathan.porter@environment-agency.gov.uk; sabina@uchicago.edu; r.fish@kent.ac.uk; susan.chilton@ncl.ac.uk; hewitt.julie@epamail.epa.gov; elaine.connolly@defra.gsi.gov.uk; andy@sas.org.uk; klaus.glenk@SRUC.ac.uk; calum.mcphail@Sepa.org.uk; Eric.McRory@sepa.org.uk; Alistair.McVittie@SRUC.ac.uk; amanna.giles@environment-agency.gov.uk; suzanne.roberts@ksbscotland.org.uk; k.h.simpson@stir.ac.uk; dugald.tinch@utas.edu.au; tedthairs@sky.com; lisa.avery@hutton.ac.uk; andy.vinten@hutton.ac.uk; williamdwatts@yahoo.co.uk; richard.quilliam@stir.ac.uk RI Fish, Robert/C-8424-2012; McVittie, Alistair/G-7087-2012; OI Fish, Robert/0000-0001-7198-0403; McVittie, Alistair/0000-0002-7128-7446; Quilliam, Richard/0000-0001-7020-4410; Oliver, David/0000-0002-6200-562X FU Natural Environment Research Council as part of the Delivering Healthy Water project [NE/I022191/1]; European Regional Development Fund Programme; European Social Fund Convergence Programme for Cornwall; European Social Fund Convergence Programme for Isles of Scilly FX The Working Group and associated workshop series were funded by the Natural Environment Research Council as part of the Delivering Healthy Water project (NE/I022191/1). LF received funding in part by the European Regional Development Fund Programme and the European Social Fund Convergence Programme for Cornwall and the Isles of Scilly. Thanks are extended to all participants who contributed to the online survey. Finally, the constructive comments from two anonymous referees and the editor helped to improve the overall quality of this manuscript. NR 44 TC 1 Z9 1 U1 2 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0044-7447 EI 1654-7209 J9 AMBIO JI Ambio PD FEB PY 2016 VL 45 IS 1 BP 52 EP 62 DI 10.1007/s13280-015-0698-9 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA8EV UT WOS:000368038800005 PM 26392185 ER PT J AU Armstrong, BM Lazorchak, JM Jensen, KM Haring, HJ Smith, ME Flick, RW Bencic, DC Biales, AD AF Armstrong, Brandon M. Lazorchak, James M. Jensen, Kathleen M. Haring, Herman J. Smith, Mark E. Flick, Robert W. Bencic, David C. Biales, Adam D. TI Reproductive effects in fathead minnows (Pimphales promelas) following a 21 d exposure to 17 alpha-ethinylestradiol SO CHEMOSPHERE LA English DT Article DE Ethinylestradiol; Reproductive effects; Fathead minnows; Vitellogenin gene and protein ID ZEBRAFISH DANIO-RERIO; MEDAKA ORYZIAS-LATIPES; LIFE-CYCLE TEST; PIMEPHALES-PROMELAS; ENDOCRINE DISRUPTION; SYNTHETIC ESTROGEN; FISH POPULATION; RISK-ASSESSMENT; 17-ALPHA-ETHYNYLESTRADIOL; VITELLOGENIN AB 17 alpha-ethinylestradiol (EE2) is a synthetic estrogen that is an active ingredient in oral contraception and hormone replacement therapy. Surveys of wastewater treatment plant effluents and surface waters throughout the world have reported EE2 concentrations in the ng/L range, and these low levels can cause significant reproductive effects in fish. This study tested the effects of three environmentally relevant EE2 concentrations: 0.47, 1.54 and 3.92 ng/L using a 21 d short-term reproductive assay to investigate the effects of EE2 on fathead minnow (Pimephales promelas) reproduction. The two highest EE2 concentrations tested in this study caused significant liver gene expression and induction of vitellogenin plasma protein in male fathead minnows. Exposure to 3.92 ng EE2/L increased the production of plasma vitellogenin in the females. Plasma estradiol concentrations were significantly reduced in females exposed to 1.54 and 3.92 ng EE2/L. All three tested concentrations significantly reduced fathead minnow egg production after a 21 d exposure to EE2. The results of this study indicate that the previously reported no observed adverse effect concentration (NOAEC) for EE2 on fathead minnow egg production (1.0 ng/L) may be too high. Because all three treatments resulted in significantly reduced egg production, the lowest observed adverse effect concentration (LOAEC) for EE2 on fathead minnow egg production is 0.47 ng EE2/L. This research estimates a NOAEC for fathead minnow reproduction at 0.24 ng EE2/L following a 21 d exposure. Additionally, induction of vitellogenin is a sensitive indicator of estrogen exposure but does not appear to be predictive of fathead minnow egg production. Published by Elsevier Ltd. C1 [Armstrong, Brandon M.] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA. [Lazorchak, James M.; Flick, Robert W.; Bencic, David C.; Biales, Adam D.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Haring, Herman J.; Smith, Mark E.] US EPA, McConnell Grp, Cincinnati, OH 45268 USA. [Jensen, Kathleen M.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA. RP Lazorchak, JM (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin L King Dr, Cincinnati, OH 45268 USA. EM Lazorchak.Jim@epa.gov FU U.S. EPA FX This study was completely funded by the U.S. EPA. Many people contributed to the implementation and analysis of this study. Denise Gordon1, Paul Wernsing1, John Meier1, and Suzanne Jackson1 assisted with necropsy procedures. Katie Struewing2, Melissa Wratschko2, Cindy Yavorsky2 and Paul Weaver2 aided in necropsy and weekend duties. Barry Weichman3 provided assistance with liver vitellogenin gene expression. Mitch Kostich1 provided statistical analysis guidance. This manuscript has been subjected to the Agency's peer and administrative review and has been approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 45 TC 2 Z9 2 U1 16 U2 38 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 366 EP 373 DI 10.1016/j.chemosphere.2015.08.078 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400049 PM 26383263 ER PT J AU Zhuang, MB Abulikemu, G Campo, P Platten, WE Suidan, MT Venosa, AD Conmy, RN AF Zhuang, Mobing Abulikemu, Gulizhaer Campo, Pablo Platten, William E., III Suidan, Makram T. Venosa, Albert D. Conmy, Robyn N. TI Effect of dispersants on the biodegradation of South Louisiana crude oil at 5 and 25 degrees C SO CHEMOSPHERE LA English DT Article DE Dispersants; JD-2000; Corexit 9500; Biodegradation; Crude oil; Surfactant ID BIOREMEDIATION; HYDROCARBONS; ALKANES; SPILL AB This article reports biodegradation rates for a commercial dispersant, JD-2000, South Louisiana crude oil (SLC) alone, and SLC dispersed with JD-2000 at 5 and 25 degrees C. Results from the biodegradation experiments revealed that Component X, a chemical marker for JD-2000, rapidly degraded at both temperatures. The application of JD-2000 decreased by half the overall biodegradation rate of aliphatic compounds at 25 degrees C. At 5 degrees C, a residual fraction consisting of iso- and n-alkanes (C-29-C-35) persisted after 56 d. The combination of dispersant and higher temperature resulted in faster removal rates for 2- and 3-ring polycyclic aromatic hydrocarbons. When compared with Corexit 9500, our results suggest that the chemistry of the surfactant (or surfactants) in JD-2000 might have favored oil dissolution (substrate transport to the aqueous phase) as an uptake mechanism over adhesion, which requires direct contact of the biomass with the oil. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhuang, Mobing; Campo, Pablo] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. [Abulikemu, Gulizhaer; Platten, William E., III] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Suidan, Makram T.] Amer Univ Beirut, Fac Engn & Architecture, Beirut 11072020, Lebanon. [Venosa, Albert D.; Conmy, Robyn N.] US EPA, NRMRL, Cincinnati, OH 45268 USA. RP Suidan, MT (reprint author), Amer Univ Beirut, Fac Engn & Architecture, Beirut 11072020, Lebanon. EM msuidan@aub.edu.lb RI peut.etre, peut.etre/G-7835-2015; Campo, Pablo/K-7673-2015 OI Campo, Pablo/0000-0001-8569-9620 FU EPA, NRMRL, Cincinnati, OH, under Pegasus Technical Services, Inc. [EP-C-11-006] FX We thank Jan Kurtz and Diane Yates from EPA's Gulf Ecology Division (GED) at Gulf Breeze, FL, who collected the water samples in the GOM and performed the enrichments and provided them for our experiments. The research was a product of the U.S. Environmental Protection Agency's National Risk Management Research Laboratory (NRMRL) and was partially funded by EPA, NRMRL, Cincinnati, OH, under Pegasus Technical Services, Inc. Contract EP-C-11-006. NR 24 TC 1 Z9 1 U1 5 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 767 EP 774 DI 10.1016/j.chemosphere.2015.08.040 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400098 PM 26414737 ER PT J AU Sundaravadivelu, D Suidan, MT Venosa, AD Rosales, PI AF Sundaravadivelu, Devi Suidan, Makram T. Venosa, Albert D. Rosales, Pablo I. TI Characterization of solidifiers used for oil spill remediation SO CHEMOSPHERE LA English DT Article DE Oil solidifier effectiveness; FTIR; XPS; SEM; EDX; Bulk powder density ID SURFACE MODIFICATION; HEAVY OIL; SORBENT; HYDROCARBONS; NORBORNENE; RECOVERY; SEAWATER; REMOVAL AB The physical characteristics and chemical composition of oil spill solidifiers were studied, and correlation of these properties with product effectiveness enabled determination of characteristics that are desirable in a good solidifier. The analyses revealed that the commercial products were primarily comprised of organic polymers and a few trace elements. A natural sorbent, which was composed entirely of plant based matter, was also evaluated, and it had the highest oil removal capacity, but it did not produce a solid mat-like final product. Generally, solidifiers with a carbonate group, pore size greater than 5 mu m, and bulk densities lower than 0.3 g cm(-3) were found to have better efficiency and produced a cohesive rubbery final product that facilitated removal compared to sorbents. The importance of bulk density and pore size in the performance of the solidifier suggest that the primary mechanism of action was likely physical sorption. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Sundaravadivelu, Devi] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. [Suidan, Makram T.] Amer Univ Beirut, Fac Engn & Architecture, Beirut 11072020, Lebanon. [Venosa, Albert D.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Rosales, Pablo I.] Univ Cincinnati, Adv Mat Characterizat Ctr, Cincinnati, OH 45221 USA. RP Suidan, MT (reprint author), Amer Univ Beirut, Fac Engn & Architecture, Beirut 11072020, Lebanon. EM msuidan@aub.edu.lb RI Parthasarathy, Ganapriya/B-2547-2012 OI Parthasarathy, Ganapriya/0000-0002-9018-9673 FU U.S. EPA's National Risk Management Research Laboratory, Cincinnati, OH [EP-C-11-006] FX This research was supported in part by U.S. EPA's National Risk Management Research Laboratory, Cincinnati, OH under Contract No. EP-C-11-006. The use of trade names or commercial products is for identification only and does not imply endorsement by any agency of the U.S. Government. NR 40 TC 1 Z9 1 U1 0 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 1490 EP 1497 DI 10.1016/j.chemosphere.2015.10.030 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400188 PM 26498096 ER PT J AU Naile, JE Garrison, AW Avants, JK Washington, JW AF Naile, Jonathan E. Garrison, A. Wayne Avants, Jimmy K. Washington, John W. TI Isomers/enantiomers of perfluorocarboxylic acids: Method development and detection in environmental samples SO CHEMOSPHERE LA English DT Article DE Perfluorocarboxylic acids; PFCAs; PFOA; Isomers; Chiral; Enantiomers; Enantioselectivity ID TROUT ONCORHYNCHUS-MYKISS; SLUDGE-APPLIED SOILS; PERFLUOROOCTANE SULFONATE; RAINBOW-TROUT; PERFLUORINATED CHEMICALS; PERFLUOROALKYL ACIDS; TEMPORAL TRENDS; ISOMER; PERFLUOROCHEMICALS; BIOACCUMULATION AB Perfluoroalkyl substances are globally distributed in both urban and remote settings, and routinely are detected in wildlife, humans, and the environment. One of the most prominent and routinely detected perfluoroalkyl substances is perfluorooctanoic acid (PFOA), which has been shown to be toxic to both humans and animals. PFOA exists as both linear and branched isomers; some of the branched isomers are chiral. A novel GC-NCI-MS method was developed to allow for isomer/enantiomer separation, which was achieved using two columns working in tandem; a 30-m DB-5MS column and a 30-m BGB-172 Analytik column. Samples were derivatized with diazomethane to form methyl esters of the PFOA isomers. In standards, at least eight PFOA isomers were detected, of which at least four were enantiomers of chiral isomers; one chiral isomer (P3) was sufficiently separated to allow for enantiomer-fraction calculations. Soil, sediment and plant samples from contaminated locations in Alabama and Georgia were analyzed. P3 was observed in most of these environmental samples, and was non-racemic in at least one sediment, suggesting the possibility of chirally selective generation from precursors or enantioselective sorption. In addition, the ratio of P3/linear PFOA was inversely related to distance from source, which we suggest might reflect a higher sorption affinity for the P3 over the linear isomer. This method focuses on PFOA, but preliminary results suggest that it should be broadly applicable to other chiral and achiral perfluorocarboxylic acids (PFCAs); e.g., we detected several other homologous PFCA isomers in our PFCA standards and some environmental samples. Published by Elsevier Ltd. C1 [Naile, Jonathan E.; Garrison, A. Wayne; Washington, John W.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Avants, Jimmy K.] US EPA, Senior Serv Amer, Athens, GA 30605 USA. RP Washington, JW (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. EM AWGarrison@hotmail.com; Washington.John@epa.gov FU USEPA Office of Research Development FX This research was funded by the USEPA Office of Research & Development. We thank Jack Jones and Eric Weber, of the EPA, and the editor and manuscript reviewers for insightful comments. Views expressed in this paper do not necessarily represent the views or policies of the USEPA. Mention of trade names or products does not convey EPA approval, endorsement or recommendation. NR 47 TC 2 Z9 2 U1 12 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 1722 EP 1728 DI 10.1016/j.chemosphere.2015.10.075 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400218 PM 26519804 ER PT J AU Zhang, JJ Zhang, XW Xia, P Zhang, R Wu, Y Xia, J Su, GY Zhang, JM Giesy, JP Wang, ZY Villeneuve, DL Yu, HX AF Zhang, Junjiang Zhang, Xiaowei Xia, Pu Zhang, Rui Wu, Yang Xia, Jie Su, Guanyong Zhang, Jiamin Giesy, John P. Wang, Zunyao Villeneuve, Daniel L. Yu, Hongxia TI Activation of AhR-mediated toxicity pathway by emerging pollutants polychlorinated diphenyl sulfides SO CHEMOSPHERE LA English DT Article DE Toxicogenomics; Molecular initiating event; Ligand binding domain; RNA-seq; Cyp1A; Xenobiotic metabolism ID ARYL-HYDROCARBON RECEPTOR; IN-VITRO BIOASSAYS; GENE-EXPRESSION; TOXICOGENOMIC ANALYSIS; IDENTIFICATION; POTENCY; DIOXIN; TCDD; CELLS; INTEGRATION AB Polychlorinated diphenyl sulfides (PCDPSs) are a group of environmental pollutants for which limited toxicological information is available. This study tested the hypothesis that PCDPSs could activate the mammalian aryl hydrocarbon receptor (AhR) mediated toxicity pathways. Eighteen PCDPSs were tested in the H4IIE-luc transactivation assay, with 13/18 causing concentration-dependent AhR activation. Potencies of several congeners were similar to those of mono-ortho substituted polychlorinated biphenyls. A RNA sequencing (RNA-seq)-based transcriptomic analysis was performed on H4IIE cells treated with two PCDPS congeners, 2,2',3,3',4,5,6-hepta-CDPS, and 2,4,4',5-tetra-CDPS. Results of RNA-seq revealed a remarkable modulation on a relatively short gene list by exposure to the tested concentrations of PCDPSs, among which, Cyp1 responded with the greatest fold up-regulation. Both the identities of the modulated transcripts and the associated pathways were consistent with targets and pathways known to be modulated by other types of AhR agonists and there was little evidence for significant off-target effects within the cellular context of the H4IIE bioassay. The results suggest AhR activation as a toxicologically relevant mode of action for PCDPSs suggests the utility of AhR-related toxicity pathways for predicting potential hazards associated with PCDPS exposure in mammals and potentially other vertebrates. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhang, Junjiang; Zhang, Xiaowei; Xia, Pu; Zhang, Rui; Wu, Yang; Xia, Jie; Su, Guanyong; Zhang, Jiamin; Giesy, John P.; Wang, Zunyao; Yu, Hongxia] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China. [Giesy, John P.] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK, Canada. [Giesy, John P.] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada. [Giesy, John P.] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA. [Giesy, John P.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA. [Giesy, John P.] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China. [Giesy, John P.] Hong Kong Baptist Univ, Dept Biol, Kowloon, Hong Kong, Peoples R China. [Villeneuve, Daniel L.] US EPA, Mid Continent Ecol Div, Duluth, MN USA. RP Zhang, XW (reprint author), Nanjing Univ, Sch Environm, 163 Xianlin Ave, Qixia Nanjing 210000, Peoples R China. EM howard50003250@yahoo.com RI Wang, Zunyao/H-8526-2016; Su, Guanyong/A-7747-2017; OI Wang, Zunyao/0000-0002-7655-9244; Zhang, Xiaowei/0000-0001-8974-9963 FU National Natural Science Foundation of China [21322704, 21007025]; National High-tech R&D Program of China (863 Program) [2013AA06A309]; Collaborative Innovation Center for Regional Environmental Quality; State Administration of Foreign Experts Affairs, the P.R. China [GDT20143200016]; Chinese Academy of Sciences; Canada Research Chair program FX This work was supported by the National Natural Science Foundation of China (Grant No. 21322704 and 21007025), National High-tech R&D Program of China (863 Program, Grant No. 2013AA06A309). The research is also supported by the Collaborative Innovation Center for Regional Environmental Quality. Dr. Daniel L Villeneuve and Dr. John Giesy were supported by the program of 2014 "High Level Foreign Experts" (#GDT20143200016) of the State Administration of Foreign Experts Affairs, the P.R. China. Dr. John Giesy was also supported by the Einstein Professor Program of the Chinese Academy of Sciences and by the Canada Research Chair program. NR 37 TC 3 Z9 3 U1 7 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 1754 EP 1762 DI 10.1016/j.chemosphere.2015.09.107 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400222 PM 26524144 ER PT J AU Edwards, JD AF Edwards, Jonathan D. TI FEDERAL DIRECTIONS IN RADIATION REGULATIONS: MAKING THE "OLD" NEW AGAIN SO HEALTH PHYSICS LA English DT Article DE National Council on Radiation Protection and Measurements; regulations; regulatory guides; safety standards AB The radiation regulatory scheme in the United States must periodically evolve and adapt to ensure that public health, workers, and the environment are properly protected in view of accepted societal values and the advance of science, technology, and medical practices. Federal regulators must use best judgment in weighing a multitude of factors and considerations. In the early 21st century, a few dependable but tired and antiquated workhorses of regulation have been reworked already but many more remain that likely need reworking. Three primary points of discussion on current directional influences on federal radiation regulation merit examination: In 2015, what are the stressors driving societal and policy changes and how might these dynamics be forcing reexamination of old regulations? What are the things that make a good regulation and an effective rule? What are the thorny issues that the federal government is wrestling with and what are some of the notable activities in federal radiation regulations and guidance that are underway? This journal article was presented at the 2015 Annual Meeting of the National Council on Radiation Protection and Measurements and served as a broad overview of federal regulatory actions and issues. C1 [Edwards, Jonathan D.] US EPA, Radiat Protect Div, Washington, DC 20460 USA. RP Edwards, JD (reprint author), US EPA, Radiat Protect Div, 1200 Penn Ave NW,Ariel Rios Bldg,Mail Code 11 09A, Washington, DC 20460 USA. EM edwards.jonathan@epa.gov NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD FEB PY 2016 VL 110 IS 2 BP 151 EP 157 DI 10.1097/HP.0000000000000427 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA DA5CC UT WOS:000367818700014 PM 26717168 ER PT J AU DeCair, S AF DeCair, Sara TI UPDATING DOSIMETRY FOR EMERGENCY RESPONSE DOSE PROJECTIONS SO HEALTH PHYSICS LA English DT Article DE National Council on Radiation Protection and Measurements; dosimetry; emergency planning; emergencies; radiological AB In 2013, the U.S. Environmental Protection Agency (EPA) proposed an update to the 1992 Protective Action Guides (PAG) Manual. The PAG Manual provides guidance to state and local officials planning for radiological emergencies. EPA requested public comment on the proposed revisions, while making them available for interim use by officials faced with an emergency situation. Developed with interagency partners, EPA's proposal incorporates newer dosimetric methods, identifies tools and guidelines developed since the current document was issued, and extends the scope of the PAGs to all significant radiological incidents, including radiological dispersal devices or improvised nuclear devices. In order to best serve the emergency management community, scientific policy direction had to be set on how to use International Commission on Radiological Protection Publication 60 age groups in dose assessment when implementing emergency guidelines. Certain guidelines that lend themselves to different PAGs for different subpopulations are the PAGs for potassium iodide (KI), food, and water. These guidelines provide age-specific recommendations because of the radiosensitivity of the thyroid and young children with respect to ingestion and inhalation doses in particular. Taking protective actions like using KI, avoiding certain foods or using alternative sources of drinking water can be relatively simple to implement by the parents of young children. Clear public messages can convey which age groups should take which action, unlike how an evacuation or relocation order should apply to entire households or neighborhoods. New in the PAG Manual is planning guidance for the late phase of an incident, after the situation is stabilized and efforts turn toward recovery. Because the late phase can take years to complete, decision makers are faced with managing public exposures in areas not fully remediated. The proposal includes quick-reference operational guidelines to inform re-entry to the contaminated zone. Broad guidance on approaches to wide-area cleanup and cleanup goals is also provided. EPA adapted the cleanup process from the 2008 U.S. Department of Homeland Security (DHS) Planning Guidance for Protection and Recovery Following Radiological Dispersal Device (RDD) and Improvised Nuclear Device (IND) Incidents, and the final PAG Manual will supersede that DHS guidance. Waste management guidance is also provided. Recognizing that an incident could result in radioactive waste volumes that severely strain or exceed available resources and capacity, officials may consider alternatives for disposal of waste that is relatively lightly contaminated. Waste management, including treatment, staging, and interim and long-term storage, must be an integral part of recovery. C1 [DeCair, Sara] US EPA, Washington, DC 20460 USA. RP DeCair, S (reprint author), US EPA, 1200 Penn Ave NW, Washington, DC 20460 USA. EM decair.sara@epa.gov NR 24 TC 1 Z9 1 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD FEB PY 2016 VL 110 IS 2 BP 217 EP 221 DI 10.1097/HP.0000000000000433 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA DA5CC UT WOS:000367818700029 PM 26717183 ER PT J AU Lu, HF Lin, BL Campbell, DE Sagisaka, M Ren, H AF Lu, Hong-fang Lin, Bin-le Campbell, Daniel E. Sagisaka, Masayuki Ren, Hai TI Interactions among energy consumption, economic development and greenhouse gas emissions in Japan after World War II SO RENEWABLE & SUSTAINABLE ENERGY REVIEWS LA English DT Review DE Energy consumption; Economic development; GHG emissions; Emergy evaluation; Post WWII Japan ID INPUT-OUTPUT-ANALYSIS; CO2 EMISSIONS; CAUSALITY RELATIONSHIP; BIOGEOCHEMICAL CYCLES; FINANCIAL DEVELOPMENT; INTEGRATED EMERGY; US TRADE; CHINA; GROWTH; COUNTRIES AB The long-term dynamic changes in the triad, energy consumption, economic development, and Greenhouse gas (GHG) emissions, in Japan after World War II were quantified, and the interactions among them were analyzed based on an integrated suite of energy, emergy and economic indices. The results quantitatively showed that two different energy strategy periods, one before 1973 using new sources of higher quality energy and one after 1973 focused on improving the efficiency of energy generation methods, could explain the linear increase in national economic development in Japan over the 66 years from 1946 to 2011. Japan benefited both ecologically and economically from importing fossil fuels, which accounted for 8.7% of the nominal GDP of japan averaged over the entire study period. The total environmental impacts of GHG (i.e., CO2, CH4 and N2O) emissions measured by emergy decreased after 1997, and since 2009 they have remained lower than 76% of the emissions in 1990, even though no decrease in the global warming impact based on the weight of CO2 was observed. Emergy methods and Energy Systems models revealed aspects of the complicated interactions among energy consumption, economic development, and the potential environmental impact of GHG emissions which formerly had not been recognized. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Lu, Hong-fang; Ren, Hai] Chinese Acad Sci, Key Lab Vegetat Restorat & Management Degraded Ec, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. [Lin, Bin-le; Sagisaka, Masayuki] Natl Inst Adv Ind Sci & Technol, Res Inst Sci Safety & Sustainabil RISS, Tsukuba, Ibaraki 3058569, Japan. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA. RP Lin, BL (reprint author), Natl Inst Adv Ind Sci & Technol, Res Inst Sci Safety & Sustainabil RISS, Tsukuba, Ibaraki 3058569, Japan. EM luhf@scbg.ac.cn; binle-lin@aist.go.jp; Campbell.dan@epa.gov; m.sagisaka@aist.go.jp; renhai@scbg.ac.cn FU Program of Asia Biomass Energy Researcher Invitation Program of the New Energy Foundation (NEF) of Japan; National Natural Science Foundation of China [31170428] FX This study was supported by the Program of Asia Biomass Energy Researcher Invitation Program 2012 of the New Energy Foundation (NEF) of Japan, and the Projects of the National Natural Science Foundation of China (31170428). We would like to thank the two anonymous reviewers for their coherent and valuable suggestions which have greatly improved the quality of this paper. NR 100 TC 5 Z9 5 U1 7 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1364-0321 J9 RENEW SUST ENERG REV JI Renew. Sust. Energ. Rev. PD FEB PY 2016 VL 54 BP 1060 EP 1072 DI 10.1016/j.rser.2015.10.062 PG 13 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Energy & Fuels SC Science & Technology - Other Topics; Energy & Fuels GA DA4GM UT WOS:000367758200079 ER PT J AU Li, X Kapoor, V Impellitteri, C Chandran, K Domingo, JWS AF Li, Xuan Kapoor, Vikram Impellitteri, Christopher Chandran, Kartik Domingo, Jorge W. Santo TI Measuring nitrification inhibition by metals in wastewater treatment systems: Current state of science and fundamental research needs SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY LA English DT Review DE nitrification inhibition; wastewater; heavy metals; ammonia oxidation ID AMMONIA-OXIDIZING BACTERIA; 16S RIBOSOMAL-RNA; REAL-TIME PCR; ACTIVATED-SLUDGE SYSTEMS; SILVER NANOPARTICLE DISSOLUTION; GRADIENT GEL-ELECTROPHORESIS; MOLECULAR MICROBIAL ECOLOGY; NITROSOMONAS-EUROPAEA 19718; IN-SITU HYBRIDIZATION; FULL-SCALE MUNICIPAL AB Wastewater treatment is an important step within the water continuum as it reduces the risks associated with microorganisms as well as organic and inorganic compounds. From a chemical standpoint, treatment effectiveness is generally linked to carbon and nutrient (e.g., nitrogen, phosphorus) removal. A critical step in nitrogen removal is initiated by the conversion of ammonia to nitrate, a process that is carried out by nitrifying microorganisms. Nitrification is considered a key step as it removes the toxic effect of ammonia, while the resulting nitrate can be further converted into N-2 gas (by autotrophic or heterotrophic nitrifying bacteria), which is not harmful to the environment. As nitrification is susceptible to a wide range of inhibitory substances, measuring the effect of potential inhibitors on nitrification rates is relevant to maintaining the performance of treatment plants. In this review we discuss the primary methods used to measure nitrification inhibition, their applications, and potential limitations. The authors also identify the research gaps that need to be addressed to better assess inhibition, with special attention on the effect of metals on nitrification in engineered wastewater treatment systems. C1 [Li, Xuan; Kapoor, Vikram; Impellitteri, Christopher; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. [Chandran, Kartik] Columbia Univ, Dept Earth & Environm Engn, New York, NY USA. RP Domingo, JWS (reprint author), US EPA, Off Res & Dev, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. EM santodomingo.jorge@epa.gov FU ORISE-EPA Research Fellowship; Water Environment Research Foundation; U.S. Environmental Protection Agency, through its Office of Research and Development FX Drs. Li and Kapoor were supported by ORISE-EPA Research Fellowship. Dr. Chandran was supported by the Water Environment Research Foundation. The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein. This work has been subjected to the agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the agency; therefore, no official endorsement should be inferred. NR 162 TC 4 Z9 4 U1 26 U2 86 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1064-3389 EI 1547-6537 J9 CRIT REV ENV SCI TEC JI Crit. Rev. Environ. Sci. Technol. PD FEB 1 PY 2016 VL 46 IS 3 BP 249 EP 289 DI 10.1080/10643389.2015.1085234 PG 41 WC Environmental Sciences SC Environmental Sciences & Ecology GA CZ0ZZ UT WOS:000366836700003 ER PT J AU Wang, RL Biales, AD Garcia-Reyero, N Perkins, EJ Villeneuve, DL Ankley, GT Bencic, DC AF Wang, Rong-Lin Biales, Adam D. Garcia-Reyero, Natalia Perkins, Edward J. Villeneuve, Daniel L. Ankley, Gerald T. Bencic, David C. TI Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles SO BMC GENOMICS LA English DT Article DE Fish; Gene expression profiles; Connectivity mapping ID MINNOWS PIMEPHALES-PROMELAS; GENE-EXPRESSION SIGNATURES; BISPHENOL-A; ANDROGEN RECEPTOR; RISK-ASSESSMENT; HYDROCARBON RECEPTOR; MOLECULAR TARGET; ECOLOGICAL RISK; FATHEAD MINNOW; ZEBRAFISH AB Background: A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially of great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) in biomedical research, this study was undertaken to investigate the utility of an analogous Cmap approach in ecotoxicology. Over 3500 zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) transcriptomic profiles, each associated with one of several dozen chemical treatment conditions, were compiled into three distinct collections of rank-ordered gene lists (ROGLs) by species and microarray platforms. Individual query signatures, each consisting of multiple gene probes differentially expressed in a chemical condition, were used to interrogate the reference ROGLs. Results: Informative connections were established at high success rates within species when, as defined by their mechanisms of action (MOAs), both query signatures and ROGLs were associated with the same or similar chemicals. Thus, a simple query signature functioned effectively as an exposure biomarker without need for a time-consuming process of development and validation. More importantly, a large reference database of ROGLs also enabled a query signature to cross-interrogate other chemical conditions with overlapping MOAs, leading to novel groupings and subgroupings of seemingly unrelated chemicals at a finer resolution. This approach confirmed the identities of several estrogenic chemicals, as well as a polycyclic aromatic hydrocarbon and a neuro-toxin, in the largely uncharacterized water samples near several waste water treatment plants, and thus demonstrates its future potential utility in real world applications. Conclusions: The power of Cmap should grow as chemical coverages of ROGLs increase, making it a framework easily scalable in the future. The feasibility of toxicity extrapolation across fish species using Cmap needs more study, however, as more gene expression profiles linked to chemical conditions common to multiple fish species are needed. C1 [Wang, Rong-Lin; Biales, Adam D.; Bencic, David C.] US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Corps Engineers, US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. RP Wang, RL (reprint author), US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. EM Wang.Rong-Lin@epa.gov FU US Environmental Protection Agency (USEPA); U.S. Army Environmental Quality and Installations program; U.S. Army [BAA 11-4838] FX Funding for zebrafish exposures and microarray analysis was provided by US Environmental Protection Agency (USEPA). The U.S. Army Environmental Quality and Installations program and U.S. Army (grant BAA 11-4838) provided funding for fathead minnow microarrays analysis. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. We thank Lynn Escalon and Xin Guan in the Environmental Laboratory, US Army Engineer Research and Development Center for microarray data generation. The internal technical review was conducted by Mark Nelms at the National Health and Environmental Effects Research Laboratory, USEPA. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the USEPA. The manuscript has been approved for publication by USEPA and US Army Corps Chief of Engineers. NR 62 TC 0 Z9 0 U1 5 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD JAN 28 PY 2016 VL 17 AR 84 DI 10.1186/s12864-016-2406-y PG 20 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DC0GH UT WOS:000368894700001 PM 26822894 ER PT J AU Tinling, MA West, JJ Cascio, WE Kilaru, V Rappold, AG AF Tinling, Melissa A. West, J. Jason Cascio, Wayne E. Kilaru, Vasu Rappold, Ana G. TI Repeating cardiopulmonary health effects in rural North Carolina population during a second large peat wildfire SO ENVIRONMENTAL HEALTH LA English DT Article DE Wildfire smoke; Respiratory effects; Cardiovascular effects; Hypertension; Peat fire ID FOREST-FIRE SMOKE; SOUTHERN CALIFORNIA WILDFIRES; AIR-POLLUTION; CARDIOVASCULAR HEALTH; HOSPITAL ADMISSIONS; EXPOSURE; QUALITY; MORTALITY; EMISSIONS; OUTCOMES AB Background: Cardiovascular health effects of fine particulate matter (PM2.5) exposure from wildfire smoke are neither definitive nor consistent with PM2.5 from other air pollution sources. Non-comparability among wildfire health studies limits research conclusions. Methods: We examined cardiovascular and respiratory health outcomes related to peat wildfire smoke exposure in a population where strong associations were previously reported for the 2008 Evans Road peat wildfire. We conducted a population-based epidemiologic investigation of associations between daily county-level modeled wildfire PM2.5 and cardiopulmonary emergency department (ED) visits during the 2011 Pains Bay wildfire in eastern North Carolina. We estimated changes in the relative risk cumulative over 0-2 lagged days of wildfire PM2.5 exposure using a quasi-Poisson regression model adjusted for weather, weekends, and poverty. Results: Relative risk associated with a 10 mu g/m(3) increase in 24-h PM2.5 was significantly elevated in adults for respiratory/other chest symptoms 1.06 (1.00-1.13), upper respiratory infections 1.13 (1.05-1.22), hypertension 1.05 (1.00-1.09) and 'all-cause' cardiac outcomes 1.06 (1.00-1.13) and in youth for respiratory/other chest symptoms 1.18 (1.06-1.33), upper respiratory infections 1.14 (1.04-1.24) and 'all-cause' respiratory conditions 1.09 (1.01-1.17). Conclusions: Our results replicate evidence for increased risk of cardiovascular outcomes from wildfire PM2.5 and suggest that cardiovascular health should be considered when evaluating the public health burden of wildfire smoke. C1 [Tinling, Melissa A.] N Carolina State Univ, Dept Hort, Raleigh, NC 27695 USA. [West, J. Jason] Univ N Carolina, Gillings Sch Global Publ Hlth, Environm Sci & Engn, Chapel Hill, NC USA. [Cascio, Wayne E.; Rappold, Ana G.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, 109 TW Alexander Dr, Durham, NC 27707 USA. [Kilaru, Vasu] US EPA, Natl Exposure Res Lab, Div Environm Sci, Durham, NC 27707 USA. RP Rappold, AG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, 109 TW Alexander Dr, Durham, NC 27707 USA. EM rappold.ana@epa.gov RI West, Jason/J-2322-2015 OI West, Jason/0000-0001-5652-4987 FU NIEHS NIH HHS [P30 ES010126] NR 38 TC 1 Z9 1 U1 4 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD JAN 27 PY 2016 VL 15 AR 12 DI 10.1186/s12940-016-0093-4 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DC1LD UT WOS:000368976900001 PM 26818940 ER PT J AU Datta, KJ Datta, KKR Gawande, MB Ranc, V Cepe, K Malgras, V Yamauchi, Y Varma, RS Zboril, R AF Datta, Kasibhatta Josena Datta, Kasibhatta Kumara Ramanatha Gawande, Manoj B. Ranc, Vaclav Cepe, Klara Malgras, Victor Yamauchi, Yusuke Varma, Rajender S. Zboril, Radek TI Pd@Pt Core-Shell Nanoparticles with Branched Dandelion-like Morphology as Highly Efficient Catalysts for Olefin Reduction SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE core-shell nanoparticles; heterogeneous catalysis; olefins; palladium; platinum reduction ID AROMATIC NITRO-COMPOUNDS; ENHANCED ELECTROCATALYTIC ACTIVITY; OXIDE HYDROXIDE CATALYST; OXYGEN REDUCTION; HYDRAZINE HYDRATE; NANOSTRUCTURED MATERIALS; BIMETALLIC NANOCRYSTALS; TRANSFER HYDROGENATION; PHASE SYNTHESIS; PLATINUM AB A facile synthesis based on the addition of ascorbic acid to a mixture of Na2PdCl4, K2PtCl6, and Pluronic P123 results in highly branched core-shell nanoparticles (NPs) with a micro-mesoporous dandelion-like morphology comprising Pd core and Pt shell. The slow reduction kinetics associated with the use of ascorbic acid as a weak reductant and suitable Pd/Pt atomic ratio (1: 1) play a principal role in the formation mechanism of such branched Pd@Pt core-shell NPs, which differs from the traditional seed-mediated growth. The catalyst efficiently achieves the reduction of a variety of olefins in good to excellent yields. Importantly, higher catalytic efficiency of dandelion-like Pd@Pt core-shell NPs was observed for the olefin reduction than commercially available Pt black, Pd NPs, and physically admixed Pt black and Pd NPs. This superior catalytic behavior is not only due to larger surface area and synergistic effects but also to the unique micromesoporous structure with significant contribution of mesopores with sizes of several tens of nanometers. C1 [Datta, Kasibhatta Josena; Datta, Kasibhatta Kumara Ramanatha; Gawande, Manoj B.; Ranc, Vaclav; Cepe, Klara; Zboril, Radek] Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Slechtitelu 27, Olomouc 78371, Czech Republic. [Malgras, Victor; Yamauchi, Yusuke] Natl Inst Mat Sci, Res Ctr Mat Nanoarchitecton MANA, WPI, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA. RP Gawande, MB; Zboril, R (reprint author), Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Slechtitelu 27, Olomouc 78371, Czech Republic. EM manoj.gawande@upol.cz; radek.zboril@upol.cz RI Malgras, Victor/A-8221-2015; Zboril, Radek/F-5153-2015; OI Malgras, Victor/0000-0002-5667-9118; Zboril, Radek/0000-0002-3147-2196 FU Ministry of Education, Youth and Sports of the Czech Republic [LO1305]; Operational Program Education for Competitiveness: European Social Fund [CZ.1.07/2.3.00/30.0041, CZ.1.07/2.3.00/30.0004] FX The authors thank Ms. J. Straska for TEM, Mr. M. Petr for XPS, Dr. C. Aparicio for XRD, Mr. M. Krizek for porosity and adsorption-desorption measurements, and Dr. J. Tucek for technical assistance. The authors acknowledge support from the Ministry of Education, Youth and Sports of the Czech Republic (LO1305) and the Operational Program Education for Competitiveness: European Social Fund (projects CZ.1.07/2.3.00/30.0041 and CZ.1.07/2.3.00/30.0004). NR 60 TC 6 Z9 6 U1 19 U2 79 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD JAN 26 PY 2016 VL 22 IS 5 BP 1577 EP 1581 DI 10.1002/chem.201503441 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA DC0QZ UT WOS:000368924100003 PM 26455725 ER PT J AU Huesing, JE Andres, D Braverman, MP Burns, A Felsot, AS Harrigan, GG Hellmich, RL Reynolds, A Shelton, AM van Rijssen, WJ Morris, EJ Eloff, JN AF Huesing, Joseph E. Andres, David Braverman, Michael P. Burns, Andrea Felsot, Allan S. Harrigan, George G. Hellmich, Richard L. Reynolds, Alan Shelton, Anthony M. van Rijssen, Wilna Jansen Morris, E. Jane Eloff, Jacobus N. TI Global Adoption of Genetically Modified (GM) Crops: Challenges for the Public Sector SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE agricultural biotechnology; genetically modified crops; regulatory assessments ID WESTERN CORN-ROOTWORM; FRUGIPERDA LEPIDOPTERA-NOCTUIDAE; FIELD-EVOLVED RESISTANCE; HORIZONTAL GENE-TRANSFER; GREEN-REVOLUTION; PESTICIDE USE; INSECT RESISTANCE; TRANSGENIC MAIZE; BT CROPS; IMPACT AB Advances in biotechnology continue to drive the development of a wide range of insect-protected, herbicide-tolerant, stress-tolerant, and nutritionally enhanced genetically modified (GM) crops, yet societal and public policy considerations may slow their commercialization. Such restrictions may disproportionately affect developing countries, as well as smaller entrepreneurial and public sector initiatives. The 2014 IUPAC International Congress of Pesticide Chemistry (San Francisco, CA, USA; August 2014) included a symposium on "Challenges Associated with Global Adoption of Agricultural Biotechnology" to review current obstacles in promoting GM crops. Challenges identified by symposium presenters included (i) poor public understanding of GM technology and the need for enhanced communication strategies, (ii) nonharmonized and prescriptive regulatory requirements, and (iii) limited experience with regulations and product development within some public sector programs. The need for holistic resistance management programs to enable the most effective use of insect-protected crops was also a point of emphasis. This paper provides details on the symposium discussion and provides background information that can be used in support of further adoption of beneficial GM crops. Overall, it emphasizes that global adoption of modern agricultural biotechnology has not only provided benefits to growers and consumers but has great potential to provide solutions to an increasing global population and diminishing agricultural land. This potential will be realized by continued scientific innovation, harmonized regulatory systems, and broader communication of the benefits of the high-yielding, disease-resistant, and nutritionally enhanced crops attainable through modern biotechnology. C1 [Huesing, Joseph E.] US Agcy Int Dev, Bur Food Secur, Div Res, Washington, DC 20004 USA. [Andres, David] Bayer Cropsci AG, Alfred Nobel Str 50, D-40789 Monheim, Germany. [Braverman, Michael P.] Rutgers State Univ, IR Project 4, Princeton, NJ 08540 USA. [Burns, Andrea] Syngenta Crop Protect LLC, 3054 East Cornwallis Rd, Res Triangle Pk, NC 27709 USA. [Felsot, Allan S.] Washington State Univ, Dept Entomol, Richland, WA 99354 USA. [Harrigan, George G.] Monsanto Co, 800 N Lindbergh Blvd, St Louis, MO 63167 USA. [Hellmich, Richard L.] Iowa State Univ, USDA ARS, Corn Insects & Crop Genet Res Unit, Ames, IA 50011 USA. [Hellmich, Richard L.] Iowa State Univ, Dept Entomol, Ames, IA 50011 USA. [Reynolds, Alan] US EPA, Biopesticides & Pollut Prevent Div, Washington, DC 20460 USA. [Shelton, Anthony M.] Cornell Univ, Dept Entomol, NYSAES, Geneva, NY 14456 USA. [van Rijssen, Wilna Jansen; Eloff, Jacobus N.] Univ Pretoria, Fac Vet Sci, Dept Paraclin Sci, Phytomed Programme, Private Bag X04, ZA-0110 Onderstepoort, South Africa. [Morris, E. Jane] Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire, England. [Andres, David] Representing Europabio, Ave Armee 6, B-1040 Etterbeek, Belgium. RP Huesing, JE (reprint author), US Agcy Int Dev, Bur Food Secur, Div Res, Washington, DC 20004 USA. EM jhuesing@usaid.gov NR 63 TC 5 Z9 5 U1 30 U2 119 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD JAN 20 PY 2016 VL 64 IS 2 BP 394 EP 402 DI 10.1021/acs.jafc.5b05116 PG 9 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA DB5OD UT WOS:000368562600003 PM 26751159 ER PT J AU Meyer, DE Katz, JP AF Meyer, David E. Katz, John P. TI Analyzing the environmental impacts of laptop enclosures using screening-level life cycle assessment to support sustainable consumer electronics SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Consumer electronics; Life cycle assessment; Plastics; Bamboo; Aluminum ID COMPUTER; EMISSION AB The market growth of consumer electronics makes it essential for industries and policy-makers to work together to develop sustainable products. The objective of this study is to better understand how to promote environmentally sustainable consumer electronics by examining the use of various materials in laptop enclosures (excluding mounting hardware, internal components, and insulation) using screening-level life cycle assessment. The baseline material, is a fossil plastic blend of polycarbonate-acrylonitrile butadiene styrene. Alternative materials include polylactic acid, bamboo, aluminum, and various combinations of these materials known to be currently used or being considered for use in laptops. The flame retardants considered in this study are bisphenol A bis(diphenyl phosphate), triphenyl phosphate, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, and borax-boric acid-phosphorous acid. The Tool for the Reduction and Assessment of Chemical and other environmental Impacts v2.1 was used for the assessment of impacts related to climate change, human and ecological health, and resource use. The assessment demonstrates that plastics, relative to the other materials, are currently some of the better performing materials in terms of having the lowest potential environmental impact for a greater number of impact categories based on product life cycle models developed in this study. For fossil plastics, the material performance increases with increasing post-consumer recycled content. To best characterize and improve the environmental sustainability of bio-based materials like polylactic acid, it will be necessary to better model end-of-life options for this application. The impacts of using pressed bamboo materials in laptop enclosures can be lessened by improving key sub-processes, such as strip gluing. The final issue highlighted by this study is the need to develop more sustainable alternatives for flame retardants and fillers because they can represent a significant portion of the cradle-to-grave life cycle impacts, even though they often constitute a small portion of the weight of the final product. Published by Elsevier Ltd. C1 [Meyer, David E.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Katz, John P.] US EPA, San Francisco, CA 94105 USA. RP Meyer, DE (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM meyer.david@epa.gov FU EPA [EP-C-11-039-TO1] FX The authors would like to acknowledge the work of Dr. Mary Ann Curran, retired EPA senior scientist, for her efforts in developing and initiating this project. We would like to acknowledge the Cadmus Group, Inc. for their help in establishing life cycle models and preliminary inventory data through EPA contract vehicle EP-C-11-039-TO1 We would finally like to acknowledge Holly Elwood of US EPA's Office of Chemical Safety and Pollution Prevention for her invaluable insights throughout in evaluating the material life cycles. NR 59 TC 1 Z9 1 U1 5 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD JAN 20 PY 2016 VL 112 BP 369 EP 383 DI 10.1016/j.jclepro.2015.05.143 PN 1 PG 15 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA DB0OF UT WOS:000368206700039 ER PT J AU Betowski, D Bevington, C Allison, TC AF Betowski, Don Bevington, Charles Allison, Thomas C. TI Estimation of Radiative Efficiency of Chemicals with Potentially Significant Global Warming Potential SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID AB-INITIO CALCULATIONS; VIBRATIONAL FREQUENCIES; INFRARED INTENSITIES; GREENHOUSE GASES; CFC SUBSTITUTES; HYDROFLUOROETHERS AB Halogenated chemical substances are used in a broad array of applications, and new chemical substances are continually being developed and introduced into commerce. While recent research has considerably increased our understanding of the global warming potentials (GWPs) of multiple individual chemical substances, this research inevitably lags behind the development of new chemical substances. There are currently over 200 substances known to have high GWP. Evaluation of schemes to estimate radiative efficiency (RE) based on computational chemistry are useful where no measured IR spectrum is available. This study assesses the reliability of values of RE calculated using computational chemistry techniques for 235 chemical substances against the best available values. Computed vibrational frequency data is used to estimate RE values using several Pinnock-type models, and reasonable agreement with reported values is found. Significant improvement is obtained through scaling of both vibrational frequencies and intensities. The effect of varying the computational method and basis set used to calculate the frequency data is discussed. It is found that the vibrational intensities have a strong dependence on basis set and are largely responsible for differences in computed RE values. C1 [Betowski, Don] US EPA, Natl Exposure Res Lab, Div Environm Sci, POB 93478, Las Vegas, NV 89193 USA. [Bevington, Charles] US EPA, Off Pollut Prevent & Tox, Risk Assessment Div, 1200 Penn Ave NW,Mail Code 7408M, Washington, DC 20460 USA. [Allison, Thomas C.] NIST, Mat Measurement Lab, 100 Bur Dr,Stop 8320, Gaithersburg, MD 20899 USA. RP Betowski, D (reprint author), US EPA, Natl Exposure Res Lab, Div Environm Sci, POB 93478, Las Vegas, NV 89193 USA. EM betowski.don@epa.gov FU United States Environmental Protection Agency FX We thank Jeff Yang and Lindsay Stanek of the U.S. EPA for thoughtful reviews of this work and Deborah Ottinger, Margaret Sheppard, Carol Hetfield also of the U.S. EPA for help in defining the scope of this work. We would also like to acknowledge the computer time at the Environmental Modeling and Visualization Laboratory provided for this project. This work is an official contribution of the United States Environmental Protection Agency and the National Institute of Standards and Technology and is not subject to copyright in the United States. The information in this document has been funded by the United States Environmental Protection Agency. It has been subjected to the Agency's peer and administrative review and has been approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA or NIST for use. NR 25 TC 2 Z9 2 U1 3 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 19 PY 2016 VL 50 IS 2 BP 790 EP 797 DI 10.1021/acs.est.5b04154 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DB5OL UT WOS:000368563400030 PM 26647007 ER PT J AU Cyphert, JM McGee, MA Nyska, A Schladweiler, MC Kodavanti, UP Gavett, SH AF Cyphert, Jaime M. McGee, Marie A. Nyska, Abraham Schladweiler, Mette C. Kodavanti, Urmila P. Gavett, Stephen H. TI Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID LIBBY AMPHIBOLE ASBESTOS; BRONCHIOLOALVEOLAR CARCINOMA; INTRATRACHEAL INSTILLATION; LUNG-FUNCTION; EXPOSURE; MESOTHELIOMA; DEFINITIONS; ASBESTIFORM; INHALATION; MONTANA AB Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dorado tremolite (ED), and Ontario ferroactinolite cleavage fragments (ON) were compared in male Fischer 344 (F344) rats 15 mo after exposure. Rat-respirable fractions of LA and SM displayed greater mean lengths and aspect ratios than ED and ON. After a single intratracheal (IT) instillation (0.5 or 1.5 mg/rat), persistent changes in ventilatory parameters and a significant increase in lung resistance at baseline and after methacholine aerosol dosing were found only in rats exposed to 1.5 mg SM. High-dose ED significantly elevated bronchoalveolar lavage lactate dehydrogenase (LDH) activity and protein levels, while high-dose SM increased gamma-glutamyl transferase and LDH activities. A moderate degree of lung interstitial fibrosis after exposure to 1.5 mg SM persisted 15 mo after exposure, unchanged from previous findings at 3 mo. LA induced mild fibrosis, while ED and ON produced minimal and no apparent fibrosis, respectively. Bronchioloalveolar carcinoma was observed 15 mo after exposure to LA or ED. Data demonstrated that SM, given by bolus IT dosing on an equivalent mass basis, induced greater pulmonary function deficits, airway hyperresponsiveness, and interstitial fibrosis than other NOA, although unlike LA and ED, no apparent evidence for carcinogenicity was found. All NOA samples except ON cleavage fragments produced some degree of long-term toxicity. C1 [Cyphert, Jaime M.] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC USA. [McGee, Marie A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Nyska, Abraham] NIEHS, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. [Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Timrat, Israel. [Schladweiler, Mette C.; Kodavanti, Urmila P.; Gavett, Stephen H.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Gavett, SH (reprint author), US EPA, DABT, Mail Code B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gavett.stephen@epa.gov OI McGee, Marie/0000-0001-8572-1613 FU U.S. Environmental Protection Agency/University of North Carolina Toxicology Research Program Training Agreement [CR83515201-0]; U.S. Environmental Protection Agency (Region 8 and Office of Solid Waste and Emergency Response) FX This work was supported by a U.S. Environmental Protection Agency/University of North Carolina Toxicology Research Program Training Agreement (CR83515201-0) and the U.S. Environmental Protection Agency (Region 8 and Office of Solid Waste and Emergency Response). The authors thank Judy Richards for technical assistance, and Julie Wroble for manuscript review. Jaime M. Cyphert and Marie A. McGee contributed equally to this work. NR 45 TC 3 Z9 3 U1 2 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PD JAN 17 PY 2016 VL 79 IS 2 BP 49 EP 60 DI 10.1080/15287394.2015.1099123 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DF2OP UT WOS:000371183500001 PM 26818398 ER PT J AU Hughes, MF Edwards, BC AF Hughes, Michael F. Edwards, Brenda C. TI In vivo dermal absorption of pyrethroid pesticides in the rat SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID PERCUTANEOUS-ABSORPTION; PHARMACOKINETIC MODEL; TRANS-PERMETHRIN; CARE-CENTERS; EXPOSURE; NEUROTOXICITY; METABOLITES; HUMANS; HOMES AB Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed. The next day, the skin was dosed with 1750 nmol (312.5 nmol/cm(2)) of radiolabeled (5 mu Ci) bifenthrin, deltamethrin, or permethrin in acetone. A nonoccluding plastic cover was glued over the dosing site. The animals were placed in metabolism cages to collect excreta. At 24 h postdosing, the skin was washed with soap and water, and rats in one group were euthanized and their tissues were collected. The skin was removed and tape stripped. The remaining animals were returned to the metabolism cages after the wash for 4 d. These rats were then euthanized and handled as already described. Excreta, wash, tape strips, tissues, and carcass were analyzed for pyrethroid-derived radioactivity. The wash and tape strips removed >50% of the dose and skin retained 9-24%. Cumulative radioactivity in excreta was 0.5-7% at 24 h and 3-26% at 120 h. Radioactivity in tissues was <0.3% of the dose, while carcass retained 2 to 5%. Assuming absorption equals cumulative recovery in skin (washed and tape stripped), excreta, tissues, and carcass, absorption was permethrin ~ bifenthrin > deltamethrin at 24 h and permethrin > deltamethrin > bifenthrin at 120 h. Using the parallelogram approach with published in vitro data, human dermal absorption of these pyrethroids was estimated to be <10% of the dose. C1 [Hughes, Michael F.; Edwards, Brenda C.] US EPA, Res Triangle Pk, NC 27711 USA. RP Hughes, MF (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM hughes.michaelf@epa.gov NR 34 TC 1 Z9 1 U1 3 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PD JAN 17 PY 2016 VL 79 IS 2 BP 83 EP 91 DI 10.1080/15287394.2015.1109571 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DF2OP UT WOS:000371183500004 PM 26817658 ER PT J AU Fare, R Grosskopf, S Pasurka, C AF Faere, Rolf Grosskopf, Shawna Pasurka, Carl TI Technical change and pollution abatement costs SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE Environmental production function; Environmental technology; Ex-ante pollution abatement costs; Ex-post pollution abatement costs ID MODELING UNDESIRABLE FACTORS; EFFICIENCY EVALUATION; PRODUCTIVITY; OUTPUTS; ECONOMICS; INDUSTRY; GAINS AB There is continuing interest in the trend of costs associated with pollution abatement activities. We specify an environmental production technology to model the joint production of good and bad outputs. The joint production model calculates pollution abatement costs and identifies changes in these costs associated with: (1) technical change, (2) input changes, and (3) changes in bad output production. Estimates of the relative importance of each factor are estimated using data from 1995 to 2005 for a sample of coal-fired power plants in the United States. Finally, we discuss the potential usefulness of the decomposition model for identifying discrepancies between ex ante and ex post pollution abatement costs that are linked to the underlying joint production model. Published by Elsevier B.V. C1 [Faere, Rolf; Grosskopf, Shawna] Oregon State Univ, Dept Econ, Corvallis, OR 97331 USA. [Faere, Rolf] Oregon State Univ, Dept Agr & Resource Econ, Corvallis, OR 97331 USA. [Pasurka, Carl] US EPA, Off Policy, Washington, DC 20460 USA. RP Pasurka, C (reprint author), US EPA, Off Policy, 1200 Penn Ave, Washington, DC 20460 USA. EM rolf.fare@orst.edu; shawna.grosskopf@orst.edu; pasurka.carl@epa.gov RI Pasurka, Carl/H-8996-2016 OI Pasurka, Carl/0000-0001-9846-1507 NR 38 TC 5 Z9 5 U1 4 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 EI 1872-6860 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD JAN 16 PY 2016 VL 248 IS 2 BP 715 EP 724 DI 10.1016/j.ejor.2015.07.040 PG 10 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA CT2HB UT WOS:000362621500030 ER PT J AU Wexler, P Judson, R de Marcellus, S de Knecht, J Leinala, E AF Wexler, Philip Judson, Richard de Marcellus, Sally de Knecht, Joop Leinala, Eeva TI Health effects of toxicants: Online knowledge support SO LIFE SCIENCES LA English DT Article DE Toxicology; Computerized information; Databases; Toxicity; Environmental health; Toxicoinformatics; National Library of Medicine; US Environmental Protection Agency; OECD; Toxicology information; Chemical databases; Hazardous chemicals; Toxicology information; Toxicology databases; Environmental health database; Online toxicology information; Online toxicology resources ID COMPUTATIONAL TOXICOLOGY RESOURCE; NATIONAL-LIBRARY; ENVIRONMENTAL-HEALTH; INFORMATION; TOXICITY; DATABASE; PROGRAM; ACTOR AB Research in toxicology generates vast quantities of data which reside on the Web and are subsequently appropriated and utilized to support further research. This data includes a broad spectrum of information about chemical, biological and radiological agents which can affect health, the nature of the effects, treatment, regulatory measures, and more. Information is structured in a variety of formats, including traditional databases, portals, prediction models, and decision making support tools. Online resources are created and housed by a variety of institutions, including libraries and government agencies. This paper focuses on three such institutions and the tools they offer to the public: the National Library of Medicine (NLM) and its Toxicology and Environmental Health Information Program, the United States Environmental Protection Agency (EPA), and the Organisation for Economic Co-operation and Development (OECD). Reference is also made to other relevant organizations. Published by Elsevier Inc. C1 [Wexler, Philip] Natl Lib Med, Toxicol & Environm Hlth Informat Program, Bethesda, MD 20894 USA. [Judson, Richard] US EPA, Washington, DC USA. [de Marcellus, Sally; de Knecht, Joop; Leinala, Eeva] OECD, Environm Directorate, Environm Hlth & Safety Div, Paris, France. RP Wexler, P (reprint author), Natl Lib Med, Toxicol & Environm Hlth Informat Program, Bethesda, MD 20894 USA. OI Wexler, Philip/0000-0001-7240-7721 FU Intramural Research Program of the National Institutes of Health, National Library of Medicine FX This paper was supported by the Intramural Research Program of the National Institutes of Health, National Library of Medicine. NR 20 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 EI 1879-0631 J9 LIFE SCI JI Life Sci. PD JAN 15 PY 2016 VL 145 BP 284 EP 293 DI 10.1016/j.lfs.2015.10.002 PG 10 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA DC7AG UT WOS:000369370100034 PM 26506572 ER PT J AU Chekli, L Bayatsarmadi, B Sekine, R Sarkar, B Shen, AM Scheckel, KG Skinner, W Naidu, R Shon, HK Lombi, E Donner, E AF Chekli, L. Bayatsarmadi, B. Sekine, R. Sarkar, B. Shen, A. Maoz Scheckel, K. G. Skinner, W. Naidu, R. Shon, H. K. Lombi, E. Donner, E. TI Analytical characterisation of nanoscale zero-valent iron: A methodological review SO ANALYTICA CHIMICA ACTA LA English DT Review DE Zero-valent iron nanoparticles; Characterization techniques; Particle size; Surface chemistry; Bulk composition; Groundwater remediation ID PHOTON-CORRELATION SPECTROSCOPY; RAY PHOTOELECTRON-SPECTROSCOPY; SUPPORTED ZEROVALENT IRON; CORE-SHELL STRUCTURE; SULFITE ION SYSTEM; AQUEOUS-SOLUTION; POROUS-MEDIA; HUMIC-ACID; IN-SITU; ABSORPTION SPECTROSCOPY AB Zero-valent iron nanoparticles (nZVI) have been widely tested as they are showing significant promise for environmental remediation. However, many recent studies have demonstrated that their mobility and reactivity in subsurface environments are significantly affected by their tendency to aggregate. Both the mobility and reactivity of nZVI mainly depends on properties such as particle size, surface chemistry and bulk composition. In order to ensure efficient remediation, it is crucial to accurately assess and understand the implications of these properties before deploying these materials into contaminated environments. Many analytical techniques are now available to determine these parameters and this paper provides a critical review of their usefulness and limitations for nZVI characterisation. These analytical techniques include microscopy and light scattering techniques for the determination of particle size, size distribution and aggregation state, and X-ray techniques for the characterisation of surface chemistry and bulk composition. Example characterisation data derived from commercial nZVI materials is used to further illustrate method strengths and limitations. Finally, some important challenges with respect to the characterisation of nZVI in groundwater samples are discussed. (C) 2015 Elsevier B.V. All rights reserved. C1 [Chekli, L.; Shon, H. K.] Univ Technol Sydney, Sch Civil & Environm Engn, Broadway, NSW 2007, Australia. [Chekli, L.; Sarkar, B.; Naidu, R.; Shon, H. K.; Donner, E.] CRC CARE, Salisbury, SA 5106, Australia. [Bayatsarmadi, B.] Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia. [Sekine, R.; Sarkar, B.; Shen, A. Maoz; Naidu, R.; Lombi, E.; Donner, E.] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes Campus, SA 5095, Australia. [Scheckel, K. G.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45268 USA. [Skinner, W.] Univ S Australia, Ian Wark Res Inst, Mawson Lakes Campus, SA 5095, Australia. RP Lombi, E (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg 10, Mawson Lakes Campus, SA 5095, Australia. EM Enzo.Lombi@unisa.edu.au RI Sekine, Ryo/F-3721-2013; Donner, Erica/A-4809-2012; Lombi, Enzo/F-3860-2013; Shon, Ho Kyong/P-7057-2015; Skinner, William/A-4002-2011; OI Sekine, Ryo/0000-0001-9980-0603; Chekli, Laura/0000-0002-9353-943X; Donner, Erica/0000-0001-6465-2233; Lombi, Enzo/0000-0003-3384-0375; Shon, Ho Kyong/0000-0002-3777-7169; Skinner, William/0000-0002-9606-023X; Scheckel, Kirk/0000-0001-9326-9241 NR 166 TC 5 Z9 5 U1 24 U2 98 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 EI 1873-4324 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD JAN 15 PY 2016 VL 903 BP 13 EP 35 DI 10.1016/j.aca.2015.10.040 PG 23 WC Chemistry, Analytical SC Chemistry GA CZ3ZY UT WOS:000367043900002 PM 26709296 ER PT J AU Li, SB Ma, HB Wallis, LK Etterson, MA Riley, B Hoff, DJ Diamond, SA AF Li, Shibin Ma, Hongbo Wallis, Lindsay K. Etterson, Matthew A. Riley, Benjamin Hoff, Dale J. Diamond, Stephen A. TI Impact of natural organic matter on particle behavior and phototoxicity of titanium dioxide nanoparticles SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Nano-TiO2; Dissolved organic matter; Quenching; Aquatic organism; Linear model; Power analysis ID SOLAR UV-RADIATION; HUMIC-ACID; ENGINEERED NANOPARTICLES; TIO2 NANOPARTICLES; DEVELOPING ZEBRAFISH; CARBON NANOTUBES; BACTERIAL-GROWTH; DAPHNIA-MAGNA; NANOMATERIALS; TOXICITY AB Due to their inherent phototoxicity and inevitable environmental release, titanium dioxide nanoparticles (nano-TiO2) are increasingly studied in the field of aquatic toxicology. One of the particular interests is the interactions between nano-TiO2 and natural organic matter (NOM). In this study, a series of experiments was conducted to study the impacts of Suwannee River natural organic matter (SRNOM) on phototoxicity and particle behaviors of nano-TiO2. For Daphnia magna, after the addition of 5 mg/L SRNOM, LC50 value decreased significantly from 1.03 (0.89-1.20) mg/L to 0.26 (0.22-0.31) mg/L. For zebrafish larvae, phototoxic LC50 values were 39.9 (95% CI, 25.9-61.2) mg/L and 26.3 (95% CI, 18.3-37.8) mg/L, with or without the presence of 5 mg/L SRNOM, respectively. There was no statistically significant change of these LC50 values. The impact of SRNOM on phototoxicity of nano-TiO2 was highly dependent on test species, with D. magna being the more sensitive species. The impact on particle behavior was both qualitatively and quantitatively examined. A global predictive model for particle behavior was developed with a three-way interaction of SRNOM, TiO2 concentration, and time and an additive effect of ionic strength. Based on power analyses, 96-h exposure in bioassays was recommended for nanoparticle-NOM interaction studies. The importance of reactive oxygen species (ROS) quenching of SRNOM was also systematically studied using a novel exposure system that isolates the effects of environmental factors. These experiments were conducted with minimal impacts of other important interaction mechanisms (NOM particle stabilization, NOM UV attenuation, and NOM photosensitization). This study highlighted both the particle stabilization and ROS quenching effects of NOM on nano-TiO2 in an aquatic system. There is an urgent need for representative test materials, together with key environmental factors, for future risk assessment and regulations of nanomaterials. (C) 2015 Elsevier B.V. All rights reserved. C1 [Li, Shibin; Wallis, Lindsay K.; Etterson, Matthew A.; Riley, Benjamin; Hoff, Dale J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Ma, Hongbo] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA. [Diamond, Stephen A.] Nanosafe Inc, Blacksburg, VA USA. RP Li, SB (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA. EM li.shibin@epa.gov NR 44 TC 1 Z9 2 U1 18 U2 111 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 15 PY 2016 VL 542 BP 324 EP 333 DI 10.1016/j.scitotenv.2015.09.141 PN A PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX3MC UT WOS:000365602100034 PM 26519592 ER PT J AU Landis, MS Kamal, AS Kovalcik, KD Croghan, C Norris, GA Bergdale, A AF Landis, Matthew S. Kamal, Ali S. Kovalcik, Kasey D. Croghan, Carry Norris, Gary A. Bergdale, Amy TI The impact of commercially treated oil and gas produced water discharges on bromide concentrations and modeled brominated trihalomethane disinfection byproducts at two downstream municipal drinking water plants in the upper Allegheny River, Pennsylvania, USA SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Specific conductivity; Source attribution ID WASTE-WATER; SHALE GAS; ION; GENOTOXICITY; CHALLENGES; SPECIATION; DISPOSAL; MERCURY; RATIOS; TRACER AB In 2010, a dramatic increase in the levels of total trihalomethane (THM) and the relative proportion of brominated species was observed in finished water at several Pennsylvania water utilities (PDW) using the Allegheny River as their raw water supply. An increase in bromide (Br-) concentrations in the Allegheny River was implicated to be the cause of the elevatedwater disinfection byproducts. This study focused on quantifying the contribution of Br- froma commercialwastewater treatment facility (CWTF) that solely treats wastes from oil and gas producers and discharges into the upper reaches of the Allegheny River, and impacts on two downstream PDWs. In 2012, automated daily integrated samples were collected on the Allegheny River at six sites during three seasonal two-week sampling campaigns to characterize Br- concentrations and river dispersion characteristics during periods of high and low river discharges. The CWTF discharges resulted in significant increases in Br- compared to upstream baseline values in PDW raw drinking water intakes during periods of low river discharge. During high river discharge, the assimilative dilution capacity of the river resulted in lower absolute halide concentrations, but significant elevations Br- concentrations were still observed at the nearest downstream PDW intake over baseline river levels. On days with active CWTF effluent discharge the magnitude of bromide impact increased by 39 ppb (53%) and 7 ppb (22%) for low and high river discharge campaigns, respectively. Despite a declining trend in Allegheny River Br- (2009-2014), significant impacts from CWTF and coal-fired power plant discharges to Br- concentrations during the low river discharge regime at downstream PDW intakes was observed, resulting in small modeled increases in total THM(3%), and estimated positive shifts (41-47%) to more toxic brominated THM analogs. The lack of available coincident measurements of THM, precursors, and physical parameters limited the interpretation of historical trends. Published by Elsevier B.V. C1 [Landis, Matthew S.; Kamal, Ali S.; Kovalcik, Kasey D.; Croghan, Carry; Norris, Gary A.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA. [Bergdale, Amy] US EPA Reg 3, Off Monitoring & Assessment, Wheeling, WV 26003 USA. RP Landis, MS (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA. EM landis.matthew@epa.gov FU Office of Research and Development FX The EPA through its Office of Research and Development funded and conducted this research. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of EPA. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products do not constitute an endorsement or recommendation for use. We thank Ram Vedantham, Sania Tong-Argao, and Clay Nelson (EPA ORD) for their assistance with data Quality Assurance; Todd Krantz and Chris Impellitteri (EPA ORD), Angela McFadden, Louis Reynolds, Kelly Krock (EPA Region 3), Sam Garvey and Mike Wheeler (Alion) for their logistical assistance; and the CWTF and PDW operators for voluntary access to their facilities. NR 53 TC 4 Z9 4 U1 3 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 15 PY 2016 VL 542 BP 505 EP 520 DI 10.1016/j.scitotenv.2015.10.074 PN A PG 16 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX3MC UT WOS:000365602100052 PM 26520274 ER PT J AU Bowler, RM Beseler, CL Gocheva, VV Colledge, M Kornblith, ES Julian, JR Kim, YH Bollweg, G Lobdell, DT AF Bowler, Rosemarie M. Beseler, Cheryl L. Gocheva, Vihra V. Colledge, Michelle Kornblith, Erica S. Julian, Jaime R. Kim, Yangho Bollweg, George Lobdell, Danelle T. TI Environmental exposure to manganese in air: Associations with tremor and motor function SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Manganese; Neurotoxicity; Psychomotor; Tremor; Environment; Adult residents ID IDIOPATHIC PARKINSONS-DISEASE; OHIO COMMUNITY; WELDERS; ADULTS AB Background: Manganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Mariella, a town near a ferro-manganese smeller, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products. Methods: Chronic (>= 10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were invesligated. Participants from Mariella (n = 100) and East Liverpool (n 86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed resident's psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air Mn and motor function and tremor. Results: Air-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor. Conclusion: Tremor and motor function were associated with higher exposure to airborne Mn. (C) 2015 Elsevier B.V. All rights reserved. C1 [Bowler, Rosemarie M.; Gocheva, Vihra V.] San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA. [Beseler, Cheryl L.] Colorado State Univ, Ft Collins, CO 80523 USA. [Colledge, Michelle] ATSDR, Chicago, IL USA. [Kornblith, Erica S.] Alliant Int Univ, Calif Sch Profess Psychol, San Francisco, CA USA. [Julian, Jaime R.; Bollweg, George] US EPA, Chicago, IL USA. [Kim, Yangho] Univ Ulsan, Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan 680749, South Korea. [Lobdell, Danelle T.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Bowler, RM (reprint author), 8371 Kent Dr, El Cerrito, CA 94530 USA. EM rbowl@sfsu.edu FU U.S. Environmental Protection Agency [83416001]; EPA [EP-11-D-000424, EP-13-D-000146] FX Special thanks are given to Dr. Harry Roels for his extensive input and assistance with planning and carrying out this study. Also acknowledged for their valuable support are: Ohio Department of Health, Bureau of Environmental Health (Greg Stein, Robert Frey); East Liverpool City Health District (Ms. Jelayne Dray, Health Commissioner); East Liverpool City Council and the mayor of East Liverpool, Mr. James P. Swogger; Marietta City Health Department (Michael Brockett, Health Commissioner); and Washington County Health Department (Kathleen Meckstroth, Health Commissioner). We additionally thank Dr. Donna Mergler, Universite du Quebec a Montreal, for her generous consultation throughout this project and Stanley Durkee and William Boyes (EPA) for review of this manuscript. The research described here has been funded wholly (or in part) by the U.S. Environmental Protection Agency through cooperative agreement number 83416001 to San Francisco State University (Marietta study) and EPA Contracts EP-11-D-000424 and EP-13-D-000146 (East Liverpool study). NR 51 TC 1 Z9 1 U1 10 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 15 PY 2016 VL 541 BP 646 EP 654 DI 10.1016/j.scitotenv.2015.09.084 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CW8ZY UT WOS:000365289300069 PM 26437342 ER PT J AU Tong, ZM Baldauf, RW Isakov, V Deshmukh, P Zhang, KM AF Tong, Zheming Baldauf, Richard W. Isakov, Vlad Deshmukh, Parikshit Zhang, K. Max TI Roadside vegetation barrier designs to mitigate near-road air pollution impacts SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE CFD; Particulate matter (PM); Ultrafine particle (UFP); Urban planning; Green infrastructure; Dry deposition; Air quality ID LARGE-EDDY SIMULATION; TURBULENT-FLOW; AEROSOL DYNAMICS; WIND CONDITIONS; BLACK CARBON; CANOPY FLOW; CTAG MODEL; URBAN; FOREST; ENVIRONMENT AB With increasing evidence that exposures to air pollution near large roadways increases risks of a number of adverse human health effects, identifying methods to reduce these exposures has become a public health priority. Roadside vegetation barriers have shown the potential to reduce near-road air pollution concentrations; however, the characteristics of these barriers needed to ensure pollution reductions are not well understood. Designing vegetation barriers to mitigate near-road air pollution requires a mechanistic understanding of how barrier configurations affect the transport of traffic-related air pollutants. We first evaluated the performance of the Comprehensive Turbulent Aerosol Dynamics and Gas Chemistry (CTAG) model with Large Eddy Simulation (LES) to capture the effects of vegetation barriers on near-road air quality, compared against field data. Next, CTAG with LES was employed to explore the effects of six conceptual roadside vegetation/solid barrier configurations on near-road size-resolved particle concentrations, governed by dispersion and deposition. Two potentially viable design options are revealed: a) a wide vegetation barrier with high Leaf Area Density (LAD), and b) vegetation-solid barrier combinations, i.e., planting trees next to a solid barrier. Both designs reduce downwind particle concentrations significantly. The findings presented in the study will assist urban planning and forestry organizations with evaluating different green infrastructure design options. (C) 2015 Elsevier B.V. All rights reserved. C1 [Tong, Zheming; Zhang, K. Max] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA. [Baldauf, Richard W.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Baldauf, Richard W.; Isakov, Vlad] US EPA, Off Transportat & Air Qual, Ann Arbor, NC USA. [Deshmukh, Parikshit] Jacobs Technol, Durham, NC 27713 USA. RP Zhang, KM (reprint author), Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA. EM Kz33@cornell.edu NR 39 TC 12 Z9 13 U1 19 U2 124 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 15 PY 2016 VL 541 BP 920 EP 927 DI 10.1016/j.scitotenv.2015.09.067 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CW8ZY UT WOS:000365289300095 PM 26457737 ER PT J AU Lalley, J Han, C Li, X Dionysiou, DD Nadagouda, MN AF Lalley, Jacob Han, Changseok Li, Xuan Dionysiou, Dionysios D. Nadagouda, Mallikarjuna N. TI Phosphate adsorption using modified iron oxide-based sorbents in lake water: Kinetics, equilibrium, and column tests SO CHEMICAL ENGINEERING JOURNAL LA English DT Article DE Adsorption; Nutrients; Nutrient removal/recovery; Phosphate; Water treatment ID AQUEOUS-SOLUTION; REMOVAL; PHOSPHORUS; GOETHITE; EUTROPHICATION; PRECIPITATION; ADSORBENTS; INTERFACE; DIFFUSION; ARSENATE AB Adsorption behavior of Bayoxide (R) E33 (E33) and three E33-modified sorbents for the removal of phosphate from lake water was investigated in this study. E33-modified sorbents were synthesized by coating with manganese (E33/Mn) and silver (E33/AgI and E33/AgII).nanoparticles. Adsorbent characterization was done by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), surface area analyzer (BET), transmission electron microscopy (TEM), and high resolution TEM (HR-TEM) analysis. Batch, equilibrium, and column experiments were conducted to determine various adsorption parameters. Equilibrium data were fitted to different adsorption isotherms and the Langmuir isotherm provided the best fit. Based on the Langmuir model, it was found that E33/AgII had a slightly higher maximum monolayer adsorption capacity (38.8 mg g(-1)) when compared to unmodified E33 (37.7 mg g(-1)). Data for adsorption kinetics were found to best fit with the pseudosecond-order model, suggesting chemisorption is the mechanism of sorption. Intra-particle diffusion studies indicated that the rate-limiting step for phosphate sorption onto E33 and modified E33 was intra-particle diffusion. Although limited improvements were seen, the results of this study suggest that the surface of E33 can be modified with nanoparticles to enhance the adsorption of phosphate from aqueous solutions and may give other advantages such as limiting biofouling over an extended lifetime of numerous recovery/regeneration steps. Published by Elsevier B.V. C1 [Lalley, Jacob; Han, Changseok; Li, Xuan; Nadagouda, Mallikarjuna N.] US EPA, ORD, NRMRL, WSWRD,WQMB, Cincinnati, OH 45268 USA. [Lalley, Jacob; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, DBCEE, Cincinnati, OH 45221 USA. RP Nadagouda, MN (reprint author), US EPA, ORD, NRMRL, WSWRD,WQMB, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. EM Nadagouda.mallikarjuna@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed, or partially funded and collaborated in, the research described herein. It has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 47 TC 22 Z9 22 U1 23 U2 88 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 1385-8947 EI 1873-3212 J9 CHEM ENG J JI Chem. Eng. J. PD JAN 15 PY 2016 VL 284 BP 1386 EP 1396 DI 10.1016/j.cej.2015.08.114 PG 11 WC Engineering, Environmental; Engineering, Chemical SC Engineering GA CW5QW UT WOS:000365052600145 ER PT J AU Rossi, AM Rabenhorst, MC AF Rossi, Ann M. Rabenhorst, Martin C. TI Pedogenesis and landscape relationships of a Holocene age barrier island SO GEODERMA LA English DT Article DE Pedogenesis; Chronosequences; Toposequences; Barrier Islands; Coastal dunes; Entisols ID SOIL ORGANIC-MATTER; SEA-LEVEL RISE; DUNE SLACKS; ECOSYSTEM DEVELOPMENT; ASSATEAGUE-ISLAND; NORTH-CAROLINA; COASTAL DUNES; SAND DUNES; SALT-MARSH; CHRONOSEQUENCE AB Soil characteristics and pedogenic processes are relatively unstudied on Holocene age barrier islands in the Mid-Atlantic region of the United States. The objective of this study was to assess how landform stability and hydrologic conditions (water availability) influenced pedogenesis in barrier island soils. Ten topographic transects were established on different barrier island landforms (i.e., washover fan, back-barrier flat, barrier flat, and dune field) which ranged in age from 1 to 228 years. The topographic transects spanned drainage conditions, ranging from very poorly to excessively drained. The primary evidence for pedogenesis across the chronosequence was in the accumulation of organic matter, expressed in the formation of A and 0 horizons. Pedogenic development was restricted by the young age and weathering resistant nature of the soil parent material. The close proximity of the water table to the soil surface was associated with greater organic matter inputs from vegetation and slower decomposition under anaerobic conditions, which together led to increased accumulation of organic carbon in lower, wetter landscape positions. Frequency and duration of saturation also impacted subsoil development, producing subtle, but noticeable color differences between oxidized and reduced horizons. (C) 2015 Elsevier B.V. All rights reserved. C1 [Rossi, Ann M.; Rabenhorst, Martin C.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. [Rabenhorst, Martin C.] Univ Maryland, Dept ENST, College Pk, MD 20742 USA. RP Rossi, AM (reprint author), US EPA, ORISE Res Program, 1200 Penn Ave NW,MC 4502T, Washington, DC 20460 USA. EM rossi.annie.m@gmail.com; mrabenho@umd.edu FU Maryland Agricultural Experiment Station; USDA Natural Resources Conservation Service FX We would like to thank the National Park Service for permission to work at Assateague Island National Seashore and for their cooperation with permitting, instrumentation, monitoring, and sampling efforts. Research was funded by the Maryland Agricultural Experiment Station and the USDA Natural Resources Conservation Service. Thanks to Mark Matovich, Ashley Robey, Heather Hall, Ryan Adams, Elena Perry, and Nick Gilbert for assistance with field and laboratory work and to Gary Seibel and the UMD ENST Project Development Center for assistance with instrumentation. NR 91 TC 0 Z9 0 U1 5 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0016-7061 EI 1872-6259 J9 GEODERMA JI Geoderma PD JAN 15 PY 2016 VL 262 BP 71 EP 84 DI 10.1016/j.geoderma.2015.08.004 PG 14 WC Soil Science SC Agriculture GA CS8AO UT WOS:000362308300008 ER PT J AU Van Emon, JM AF Van Emon, Jeanette M. TI The Omics Revolution in Agricultural Research SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE agricultural research; biotech crops; genetic modifications; genomics; metabolomics; omics; plant breeding; plant transcriptomics; proteomics; transgenic crops ID MONOCLONAL-ANTIBODY; MASS-SPECTROMETRY; TRANSGENIC PLANTS; FOOD-SAFETY; METABOLOMICS; PERSPECTIVE; FOODOMICS; PROTEOMICS; INFECTION; SEQUENCE AB The Agrochemicals Division cosponsored the 13th International Union of Pure and Applied Chemistry International Congress of Pesticide Chemistry held as part of the 248th National Meeting and Exposition of the American Chemical Society in San Francisco, CA, USA, August 10-14, 2014. The topic of the Congress was Crop, Environment, and Public Health Protection; Technologies for a Changing World. Over 1000 delegates participated in the Congress with interactive scientific programming in nine major topic areas including the challenges and opportunities of agricultural biotechnology. Plenary speakers addressed global issues related to the Congress theme prior to the daily technical sessions. The plenary lecture addressing the challenges and opportunities that omic technologies provide agricultural research is presented here. The plenary lecture provided the diverse audience with information on a complex subject to stimulate research ideas and provide a glimpse of the impact of omics on agricultural research. C1 [Van Emon, Jeanette M.] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89119 USA. RP Van Emon, JM (reprint author), US EPA, Natl Exposure Res Lab, Las Vegas, NV 89119 USA. EM vanemon.jeanette@epa.gov NR 51 TC 0 Z9 0 U1 5 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD JAN 13 PY 2016 VL 64 IS 1 BP 36 EP 44 DI 10.1021/acs.jafc.5b04515 PG 9 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA DB2FE UT WOS:000368322900007 PM 26468989 ER PT J AU Unsworth, JB Corsi, C Van Emon, JM Farenhorst, A Hamilton, DJ Howard, CJ Hunter, R Jenkins, JJ Kleter, GA Kookana, RS Lalah, JO Leggett, M Miglioranza, KSB Miyagawa, H Peranginangin, N Rubin, B Saha, B Shakil, NA AF Unsworth, John B. Corsi, Camilla Van Emon, Jeanette M. Farenhorst, Annemieke Hamilton, Denis J. Howard, Cody J. Hunter, Robert Jenkins, Jeffrey J. Kleter, Gijs A. Kookana, Rai S. Lalah, Joseph O. Leggett, Michael Miglioranza, Karina S. B. Miyagawa, Hisashi Peranginangin, Natalia Rubin, Baruch Saha, Bipul Shakil, Najam A. TI Developing Global Leaders for Research, Regulation, and Stewardship of Crop Protection Chemistry in the 21st Century SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE crop protection; stewardship; sustainable agriculture; women in agriculture; smart systems; nanopesticides; GM crops; training leaders; communications; developing regions; universities ID STATE AB To provide sufficient food and fiber to the increasing global population, the technologies associated with crop protection are growing ever more sophisticated but, at the same time, societal expectations for the safe use of crop protection chemistry tools are also increasing. The goal of this perspective is to highlight the key issues that face future leaders in crop protection, based on presentations made during a symposium titled "Developing Global Leaders for Research, Regulation and Stewardship of Crop Protection Chemistry in the 21st Century", held in conjunction with the IUPAC 13th International Congress of Pesticide Chemistry in San Francisco, CA, USA, during August 2014. The presentations highlighted the fact that leaders in crop protection must have a good basic scientific training and understand new and evolving technologies, are aware of the needs of both developed and developing countries, and have good communication skills. Concern is expressed over the apparent lack of resources to meet these needs, and ideas are put forward to remedy these deficiencies. C1 [Corsi, Camilla] Syngenta Crop Protect, CH-4332 Stein, Switzerland. [Van Emon, Jeanette M.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Las Vegas, NV 89119 USA. [Farenhorst, Annemieke] Univ Manitoba, Dept Soil Sci, Fac Agr & Food Sci, Winnipeg, MB R3T 2N2, Canada. [Hamilton, Denis J.] Queensland Dept Primary Ind, Taringa, Qld 4068, Australia. [Howard, Cody J.] Calif Air Resources Board, Sacramento, CA 95812 USA. [Hunter, Robert] CropLife Int, B-1050 Brussels, Belgium. [Jenkins, Jeffrey J.] Oregon State Univ, Dept Environm & Mol Toxicol, Ag & Life Sci 1007, Corvallis, OR 97331 USA. [Kleter, Gijs A.] RIKILT Wageningen UR, NL-6700 AE Wageningen, Netherlands. [Kookana, Rai S.] CSIRO, Land & Water Natl Res Flagship CSIRO, Environm Contaminant Mitigat & Technol, Glen Osmond, SA 5064, Australia. [Lalah, Joseph O.] Tech Univ Kenya, Dept Chem Sci & Technol, Nairobi, Kenya. [Leggett, Michael] CropLife Amer, Washington, DC 20005 USA. [Miglioranza, Karina S. B.] Univ Mar del Plata, Inst Invest Marinas & Costeras, Lab Ecotoxicol & Contaminac Ambiental, CONICET,FCEyN, RA-7600 Mar Del Plata, Argentina. [Miyagawa, Hisashi] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto 6068502, Japan. [Peranginangin, Natalia] Syngenta Crop Protect LLC, Greensboro, NC 27419 USA. [Rubin, Baruch] Hebrew Univ Jerusalem, Fac Agr Food & Environm, RH Smith Inst Plant Sci & Genet Agr, IL-76100 Rehovot, Israel. [Saha, Bipul] Nagarjuna Agrichem Ltd, Hyderabad 500082, Andhra Pradesh, India. [Shakil, Najam A.] Indian Agr Res Inst, Div Agr Chem, New Delhi 110012, India. RP Unsworth, JB (reprint author), 25 Vellacotts, Chelmsford CM1 7EA, Essex, England. EM unsworjo@aol.com RI Kookana, Rai/A-5170-2012 OI Kookana, Rai/0000-0002-0477-3284 FU American Chemical Society; International Union of Pure & Applied Chemistry FX Appreciation for financial support is expressed to the American Chemical Society (Division of Agrochemicals) and the International Union of Pure & Applied Chemistry (Division of Chemistry and the Environment). NR 18 TC 1 Z9 1 U1 7 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD JAN 13 PY 2016 VL 64 IS 1 BP 52 EP 60 DI 10.1021/jf5060744 PG 9 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA DB2FE UT WOS:000368322900009 PM 25855233 ER PT J AU Watanabe, KH Mayo, M Jensen, KM Villeneuve, DL Ankley, GT Perkins, EJ AF Watanabe, Karen H. Mayo, Michael Jensen, Kathleen M. Villeneuve, Daniel L. Ankley, Gerald T. Perkins, Edward J. TI Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB (R)-Based Model of Oocyte Growth Dynamics SO PLOS ONE LA English DT Article ID TERM REPRODUCTION ASSAY; PITUITARY-GONADAL AXIS; COMPUTATIONAL MODEL; FISH; INHIBITOR; 17-BETA-TRENBOLONE; STEROIDOGENESIS; ECOTOXICOLOGY; BIOSYNTHESIS; KETOCONAZOLE AB Fish spawning is often used as an integrated measure of reproductive toxicity, and an indicator of aquatic ecosystem health in the context of forecasting potential population-level effects considered important for ecological risk assessment. Consequently, there is a need for flexible, widely-applicable, biologically-based models that can predict changes in fecundity in response to chemical exposures, based on readily measured biochemical endpoints, such as plasma vitellogenin (VTG) concentrations, as input parameters. Herein we describe a MATLAB1 version of an oocyte growth dynamics model for fathead minnows (Pimephales promelas) with a graphical user interface based upon a previously published model developed with MCSim software and evaluated with data from fathead minnows exposed to an androgenic chemical, 17 beta-trenbolone. We extended the evaluation of our new model to include six chemicals that inhibit enzymes involved in steroid biosynthesis: fadrozole, ketoconazole, propiconazole, prochloraz, fenarimol, and trilostane. In addition, for unexposed fathead minnows from group spawning design studies, and those exposed to the six chemicals, we evaluated whether the model is capable of predicting the average number of eggs per spawn and the average number of spawns per female, which was not evaluated previously. The new model is significantly improved in terms of ease of use, platform independence, and utility for providing output in a format that can be used as input into a population dynamics model. Model-predicted minimum and maximum cumulative fecundity over time encompassed the observed data for fadrozole and most propiconazole, prochloraz, fenarimol and trilostane treatments, but did not consistently replicate results fromketoconazole treatments. For average fecundity (eggs.female(-1).day(-1)), eggs per spawn, and the number of spawns per female, the range of model-predicted values generally encompassed the experimentally observed values. Overall, we found that the model predicts reproduction metrics robustly and its predictions capture the variability in the experimentally observed data. C1 [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA. [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR 97201 USA. [Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Jensen, Kathleen M.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. RP Watanabe, KH (reprint author), Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA. EM watanabk@ohsu.edu FU US Army Environmental Quality and Installations 6.1 Basic Research Program FX US Army Environmental Quality and Installations 6.1 Basic Research Program funding to KHW, MM, and EJP. United States Army Corps of Engineers cooperative agreement to KHW (# W912HZ-11-2-0023). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 38 TC 4 Z9 4 U1 1 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 12 PY 2016 VL 11 IS 1 AR e0146594 DI 10.1371/journal.pone.0146594 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA6CG UT WOS:000367888800017 PM 26756814 ER PT J AU Crouse, DL Philip, S van Donkelaar, A Martin, RV Jessiman, B Peters, PA Weichenthal, S Brook, JR Hubbell, B Burnett, RT AF Crouse, Dan L. Philip, Sajeev van Donkelaar, Aaron Martin, Randall V. Jessiman, Barry Peters, Paul A. Weichenthal, Scott Brook, Jeffrey R. Hubbell, Bryan Burnett, Richard T. TI A New Method to Jointly Estimate the Mortality Risk of Long-Term Exposure to Fine Particulate Matter and its Components SO SCIENTIFIC REPORTS LA English DT Article ID EXTENDED FOLLOW-UP; HARVARD 6 CITIES; AIR-POLLUTION; CHEMICAL-CONSTITUENTS; COHORT; ASSOCIATIONS; HEALTH; PM2.5 AB Ambient fine particulate matter (PM2.5) is composed of a complex mixture of solids and liquids (smaller than 2.5 microns in aerodynamic diameter) derived from diverse sources (e.g., human activities, including fossil fuel combustion and industrial activities; and natural sources, including volcanic ash and pollens) that varies in space and time due to atmospheric chemistry, weather, and interactions between it and other pollutants in the atmosphere1. The composition of particulate matter, therefore, varies between and within regions of the world, countries, and urban and rural areas, and is influenced by such factors as climate, proximity to an ocean, agricultural activities, transportation activities, and kinds and quantities of point source emitters(2). The proximity to sources also affects the nature of the mixture of constituents composing PM2.5 (mixing state) with a greater propensity for external mixtures of particle types closer to sources, and more homogeneity among particle types as an air mass ages and the particles undergo a greater degree of atmospheric processing. The major components of PM2.5 typically consist of: sulphate; nitrate; ammonium; chloride/sea salt; carbon - described variously as elemental carbon, organic carbon, and black carbon; crustal material, including dust and minerals; and, biological materials and organic mass(2). The level of toxicity associated with PM2.5 is strongly affected by its mass and number concentrations, in addition to particle size, shape, chemical composition, and mixing state. C1 [Crouse, Dan L.; Burnett, Richard T.] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada. [Philip, Sajeev; van Donkelaar, Aaron; Martin, Randall V.] Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada. [Martin, Randall V.] Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA. [Jessiman, Barry] Hlth Canada, Air Qual Assessment Sect, Safe Environm Directorate, Ottawa, ON K1A 0L2, Canada. [Peters, Paul A.] Univ New Brunswick, Dept Sociol, Fredericton, NB, Canada. [Weichenthal, Scott] Hlth Canada, Safe Environm Directorate, Air Hlth Sci Div, Ottawa, ON K1A 0L2, Canada. [Brook, Jeffrey R.] Environm Canada, Qual Res Div, Downsview, ON, Canada. [Brook, Jeffrey R.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Hubbell, Bryan] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Crouse, DL (reprint author), Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada. EM dan.crouse@unb.ca RI Martin, Randall/C-1205-2014; OI Martin, Randall/0000-0003-2632-8402; Peters, Paul/0000-0001-5225-2005; Hubbell, Bryan/0000-0002-7963-3438 NR 30 TC 2 Z9 2 U1 6 U2 28 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 6 PY 2016 VL 6 AR 18916 DI 10.1038/srep18916 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA8YT UT WOS:000368093600001 PM 26732864 ER PT J AU Booij, K Robinson, CD Burgess, RM Mayer, P Roberts, CA Ahrens, L Allan, IJ Brant, J Jones, L Kraus, UR Larsen, MM Lepom, P Petersen, J Profrock, D Roose, P Schafer, S Smedes, F Tixier, C Vorkamp, K Whitehouse, P AF Booij, Kees Robinson, Craig D. Burgess, Robert M. Mayer, Philipp Roberts, Cindy A. Ahrens, Lutz Allan, Ian J. Brant, Jan Jones, Lisa Kraus, Uta R. Larsen, Martin M. Lepom, Peter Petersen, Joerdis Proefrock, Daniel Roose, Patrick Schaefer, Sabine Smedes, Foppe Tixier, Celine Vorkamp, Katrin Whitehouse, Paul TI Passive Sampling in Regulatory Chemical Monitoring of Nonpolar Organic Compounds in the Aquatic Environment SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Review ID SOLID-PHASE MICROEXTRACTION; POLYCYCLIC AROMATIC-HYDROCARBONS; SEMIPERMEABLE-MEMBRANE DEVICES; QUASIMEME LABORATORY PERFORMANCE; FREELY DISSOLVED CONCENTRATIONS; PORE-WATER CONCENTRATIONS; IN-SITU BIOACCUMULATION; POLYCHLORINATED-BIPHENYLS; CONTAMINATED SEDIMENT; PARTITION-COEFFICIENTS AB We reviewed compliance monitoring requirements in the European Union, the United States, and the Oslo-Paris Convention for the protection of the marine environment of the North-East Atlantic, and evaluated if these are met by passive sampling methods for nonpolar compounds. The strengths and shortcomings of passive sampling are assessed for water, sediments, and biota. Passive water sampling is a suitable technique for measuring concentrations of freely dissolved compounds. This method yields results that are incompatible with the EU's quality standard definition in terms of total concentrations in water, but this definition has little scientific basis. Insufficient quality control is a present weakness of passive sampling in water. Laboratory performance studies and the development of standardized methods are needed to improve data quality and to encourage the use of passive sampling by commercial laboratories and monitoring agencies. Successful prediction of bioaccumulation based on passive sampling is well documented for organisms at the lower trophic levels, but requires more research for higher levels. Despite the existence of several knowledge gaps, passive sampling presently is the best available technology for chemical monitoring of nonpolar organic compounds. Key issues to be addressed by scientists and environmental managers are outlined. C1 [Booij, Kees] NIOZ Royal Netherlands Inst Sea Res, NL-1790 AB Texel, Netherlands. [Robinson, Craig D.] Marine Lab, Marine Scotland Sci, Aberdeen AB30 1AD, Scotland. [Burgess, Robert M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Mayer, Philipp] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark. [Roberts, Cindy A.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Ahrens, Lutz] Swedish Univ Agr Sci SLU, Dept Aquat Sci & Assessment, SE-75007 Uppsala, Sweden. [Allan, Ian J.] Norwegian Inst Water Res NIVA, NO-0349 Oslo, Norway. [Brant, Jan] Ctr Environm Fisheries & Aquaculture Sci, Lowestoft NR33 0HT, Suffolk, England. [Jones, Lisa] Dublin City Univ, Dublin 9, Ireland. [Kraus, Uta R.] Fed Maritime & Hydrog Agcy, D-22589 Hamburg, Germany. [Larsen, Martin M.] Aarhus Univ, Dept Biosci, DK-4000 Roskilde, Denmark. [Lepom, Peter] Fed Environm Agcy, Lab Water Anal, D-14193 Berlin, Germany. [Petersen, Joerdis; Proefrock, Daniel] Helmholtz Zentrum Geesthacht, Inst Coastal Res, Dept Marine Bioanalyt Chem, D-21502 Geesthacht, Germany. [Roose, Patrick] Royal Belgian Inst Nat Sci, Operat Directorate Nat Environm, B-1200 Brussels, Belgium. [Schaefer, Sabine] Fed Inst Hydrol, D-56068 Koblenz, Germany. [Smedes, Foppe] Masaryk Univ, RECETOX, Brno 62500, Czech Republic. [Smedes, Foppe] Deltares, NL-3508 AL Utrecht, Netherlands. [Tixier, Celine] IFREMER, Unit Biogeochem & Ecotoxicol, Lab Biogeochem Organ Contaminants, F-44311 Nantes 3, France. [Vorkamp, Katrin] Aarhus Univ, Dept Environm Sci, DK-4000 Roskilde, Denmark. [Whitehouse, Paul] Environm Agcy, Evidence Directorate, Howbery Pk OX10 8BD, England. RP Booij, K (reprint author), NIOZ Royal Netherlands Inst Sea Res, POB 59, NL-1790 AB Texel, Netherlands. EM kees.booij@nioz.nl OI /0000-0002-1088-2049; Robinson, Craig/0000-0001-8607-3208 FU Czech Ministry of Education [LO1214, LM2011028]; U.S. Strategic Environmental Research and Development Program [14 ER03-035/ER-2431] FX We acknowledge the International Council for the Exploration of the Sea (ICES) for initiating the 2013 "Workshop on the Application of Passive Sampling and Passive Dosing to Contaminants in Marine Media", which formed the starting point for the present review. The content of this article does not necessarily represent the position of ICES. Foppe Smedes acknowledges support from the Czech Ministry of Education (LO1214 and LM2011028), and Philipp Mayer from the U.S. Strategic Environmental Research and Development Program (14 ER03-035/ER-2431). Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This report has been reviewed by the U.S. EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency. NR 174 TC 9 Z9 10 U1 21 U2 87 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 5 PY 2016 VL 50 IS 1 BP 3 EP 17 DI 10.1021/acs.est.5b04050 PG 15 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA5TU UT WOS:000367866300002 PM 26619247 ER PT J AU Kimbrough, S Hays, M Preston, B Vallero, DA Hagler, GSW AF Kimbrough, Sue Hays, Michael Preston, Bill Vallero, Daniel A. Hagler, Gayle S. W. TI Episodic Impacts from California Wildfires Identified in Las Vegas Near-Road Air Quality Monitoring SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID FIRE EMISSIONS; PARTICLES; POLLUTION; LEVOGLUCOSAN; VARIABILITY; AEROSOLS AB Air pollutant concentrations near major highways are usually attributed to a combination of nearby traffic emissions and regional background, and generally presumed to be additive in nature. During a near-road measurement study conducted in Las Vegas, NV, the effects of distant -wildfires on regional air quality were indicated over a several day period in the summer of 2009. Area-wide elevated particulate levoglucosan (maximum of 0.83 mu g/m(3)) and roadside measurements of ultraviolet light-absorbing particulate matter (UVPM) in comparison to black carbon (Delta-C) were apparent over the three-day period. Back-trajectory modeling and satellite images supported the measurement results and indicated the transport of air pollutants from wildfires burning in southern California. Separating roadside measurements under apparent biomass burning event (Delta-C> 1000 ng m(-3)) and nonevent (Delta-C < 1000 ng m(-3)) periods, and constraining to specific days of week, wind speed range, wind direction from the road and traffic volume range, roadside carbon monoxide, black carbon, total particle number count (20-200 mm), and accumulation mode particle number count (100-200 nm) increased by 65%, 146%, 58%, and 366%, respectively, when biomass smoke was indicated. Meanwhile, ultrafine particles (20-100 nm) decreased by 35%. This episode indicates that the presence of aged wildfire smoke may interact with freshly emitted ultrafine particles, resulting in a decrease of particles in the ultrafine mode. C1 [Kimbrough, Sue; Hays, Michael; Hagler, Gayle S. W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Durham, NC 27709 USA. [Preston, Bill] ARCADIS US Inc, Durham, NC 27713 USA. [Vallero, Daniel A.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Durham, NC 27709 USA. RP Kimbrough, S (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Durham, NC 27709 USA. EM kimbrough.sue@epa.gov OI Kimbrough, Evelyn Sue/0000-0002-7246-0255 NR 41 TC 0 Z9 0 U1 4 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 5 PY 2016 VL 50 IS 1 BP 18 EP 24 DI 10.1021/acsest5b05038 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA5TU UT WOS:000367866300003 PM 26618236 ER PT J AU Martin, TM AF Martin, T. M. TI Prediction of in vitro and in vivo oestrogen receptor activity using hierarchical clustering SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article DE under-sampling; in vitro; hierarchical clustering; oestrogen receptor; Quantitative structure activity relationship (QSAR) ID THROUGHPUT SCREENING ASSAYS; QSAR MODELS; CLASSIFICATION; CHEMICALS; TOXICITY; ANDROGEN; BINDING; TREE AB In this study, hierarchical clustering classification models were developed to predict in vitro and in vivo oestrogen receptor (ER) activity. Classification models were developed for binding, agonist, and antagonist in vitro ER activity and for mouse in vivo uterotrophic ER binding. In vitro classification models yielded balanced accuracies ranging from 0.65 to 0.85 for the external prediction set. In vivo ER classification models yielded balanced accuracies ranging from 0.72 to 0.83. If used as additional biological descriptors for in vivo models, in vitro scores were found to increase the prediction accuracy of in vivo ER models. If in vitro activity was used directly as a surrogate for in vivo activity, the results were poor (balanced accuracy ranged from 0.49 to 0.72). Under-sampling negative compounds in the training set was found to increase the coverage (fraction of chemicals which can be predicted) and increase prediction sensitivity. C1 [Martin, T. M.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Martin, TM (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM martin.todd@epa.gov NR 39 TC 1 Z9 1 U1 3 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1062-936X EI 1029-046X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PD JAN 2 PY 2016 VL 27 IS 1 BP 17 EP 30 DI 10.1080/1062936X.2015.1125945 PG 14 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA DD9WE UT WOS:000370275600001 PM 26784454 ER PT J AU Hughes, RM Amezcua, F Chambers, DM Daniel, WM Franks, JS Franzin, W MacDonald, D Merriam, E Neall, G Pompeu, PD Reynolds, L Woody, CA AF Hughes, Robert M. Amezcua, Felipe Chambers, David M. Daniel, Wesley M. Franks, James S. Franzin, William MacDonald, Donald Merriam, Eric Neall, George Pompeu, Paulo dos Santos Reynolds, Lou Woody, Carol Ann TI AFS Position Paper and Policy on Mining and Fossil Fuel Extraction SO FISHERIES LA English DT News Item ID JUVENILE COHO SALMON; POTENTIAL IMPACTS; COPPER EXPOSURE; RAINBOW-TROUT; GAS; MARCELLUS; LEVEL; WATER; ZINC; MINE AB Following a four-year period of writing, member comment, and multiple revisions, the AFS Position Paper and Policy on Mining and Fossil Fuel Extraction was approved unanimously by the membership at the Society's annual business meeting August 19, 2015, in Portland, Oregon. The entire document can be read at fisheries.org/policy_statements; a brief summary follows. C1 [Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97333 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97333 USA. [Amezcua, Felipe] Univ Nacl Autonoma Mexico, Inst Ciencias Mar & Limnol, Mazatlan, Sinaloa, Mexico. [Chambers, David M.] Ctr Sci Publ Participat, Bozeman, MT USA. [Daniel, Wesley M.] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA. [Franks, James S.] Univ So Mississippi, Gulf Coast Res Lab, Ocean Springs, MS USA. [Franzin, William] Laughing Water Arts & Sci Inc, Winnipeg, MB, Canada. [MacDonald, Donald] MacDonald Environm Sci Ltd, Nanaimo, BC, Canada. [Merriam, Eric] W Virginia Univ, Div Forestry Nat Resources & Design, Morgantown, WV 26506 USA. [Pompeu, Paulo dos Santos] Univ Fed Lavras, Dept Biol, Lavras, MG, Brazil. [Reynolds, Lou] US Environm Protect Agcy Reg III, Freshwater Biol Team, Wheeling, WV USA. [Woody, Carol Ann] Ctr Sci Publ Participat, Anchorage, AK USA. RP Hughes, RM (reprint author), Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97333 USA. EM hughes.bob@amnisopes.com RI Pompeu, Paulo/F-6696-2012 FU U.S. Fish and Wildlife Service; U.S. Geological Survey FX This manuscript was improved by review comments from Leanne Roulson. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. We thank the National Fish Habitat Partnership and funding from the U.S. Fish and Wildlife Service and the U.S. Geological Survey for supporting development of the data used in Figure 1. NR 43 TC 1 Z9 1 U1 4 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0363-2415 EI 1548-8446 J9 FISHERIES JI Fisheries PD JAN 2 PY 2016 VL 41 IS 1 BP 12 EP 15 DI 10.1080/03632415.2016.1121742 PG 4 WC Fisheries SC Fisheries GA CZ8GA UT WOS:000367337000006 ER PT J AU Hoffman, JC Schloesser, J Trebitz, AS Peterson, GS Gutsch, M Quinlan, H Kelly, JR AF Hoffman, Joel C. Schloesser, Joshua Trebitz, Anett S. Peterson, Greg S. Gutsch, Michelle Quinlan, Henry Kelly, John R. TI Sampling Design for Early Detection of Aquatic Invasive Species in Great Lakes Ports SO FISHERIES LA English DT Article ID BIOLOGICAL INVASIONS; MARINE BIOINVASIONS; ENVIRONMENTAL DNA; MANAGEMENT; SURVEILLANCE; INFORMATION; ERADICATION; ECOSYSTEM; RICHNESS; PATTERNS AB We evaluated a pilot aquatic invasive species (AIS) early detection monitoring program in Lake Superior that was designed to detect newly introduced fishes. We established survey protocols for three major ports (Duluth-Superior, Sault Ste. Marie, Thunder Bay) and designed an adaptive cycle for routine evaluation of survey performance. Among the three ports, we found both similarities (species richness) and differences (introduced species detectability, species detection efficiency) with respect to AIS survey performance. Despite those differences, our analysis indicated potential for increasing detection efficiency at all three ports by exploiting differences in fish assemblages and sampling gears to increase rare species encounters. Using this information in the adaptive cycle, we demonstrate the ability to improve AIS detection efficiency. Our pilot monitoring program with its adaptive cycle of assessment, refinement, and implementation provides a performance-based approach to increase AIS detection efficiency over the course of a survey and within practical resource constraints. C1 [Hoffman, Joel C.; Trebitz, Anett S.; Peterson, Greg S.; Gutsch, Michelle; Kelly, John R.] US EPA, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Schloesser, Joshua; Quinlan, Henry] US Fish & Wildlife Serv, Ashland Fish & Wildlife Conservat Off, Ashland, WI USA. RP Hoffman, JC (reprint author), US EPA, Off Res & Dev, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM hoffman.joel@epa.gov NR 35 TC 0 Z9 0 U1 8 U2 32 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0363-2415 EI 1548-8446 J9 FISHERIES JI Fisheries PD JAN 2 PY 2016 VL 41 IS 1 BP 26 EP 37 DI 10.1080/03632415.2015.1114926 PG 12 WC Fisheries SC Fisheries GA CZ8GA UT WOS:000367337000009 ER PT J AU Wolf, DC Bachman, A Barrett, G Bellin, C Goodman, JI Jensen, E Moretto, A McMullin, T Pastoor, TP Schoeny, R Slezak, B Wend, K Embry, MR AF Wolf, Douglas C. Bachman, Ammie Barrett, Gordon Bellin, Cheryl Goodman, Jay I. Jensen, Elke Moretto, Angelo McMullin, Tami Pastoor, Timothy P. Schoeny, Rita Slezak, Brian Wend, Korinna Embry, Michelle R. TI Illustrative case using the RISK21 roadmap and matrix: prioritization for evaluation of chemicals found in drinking water SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE Drinking water; integrated evaluation strategy; prioritization; risk assessment; RISK21; tiered approach ID TOXICOLOGICAL CONCERN; 21ST-CENTURY ROADMAP; THRESHOLD AB The HESI-led RISK21 effort has developed a framework supporting the use of twenty-first century technology in obtaining and using information for chemical risk assessment. This framework represents a problem formulation-based, exposure-driven, tiered data acquisition approach that leads to an informed decision on human health safety to be made when sufficient evidence is available. It provides a transparent and consistent approach to evaluate information in order to maximize the ability of assessments to inform decisions and to optimize the use of resources. To demonstrate the application of the framework's roadmap and matrix, this case study evaluates a large number of chemicals that could be present in drinking water. The focus is to prioritize which of these should be considered for human health risk as individual contaminants. The example evaluates 20 potential drinking water contaminants, using the tiered RISK21 approach in combination with graphical representation of information at each step, using the RISK21 matrix. Utilizing the framework, 11 of the 20 chemicals were assigned low priority based on available exposure data alone, which demonstrated that exposure was extremely low. The remaining nine chemicals were further evaluated, using refined estimates of toxicity based on readily available data, with three deemed high priority for further evaluation. In the present case study, it was determined that the greatest value of additional information would be from improved exposure models and not from additional hazard characterization. C1 [Wolf, Douglas C.; Pastoor, Timothy P.] Syngenta Crop Protect LLC, Greensboro, NC USA. [Bachman, Ammie] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Barrett, Gordon] Hlth Canada, Ottawa, ON K1A 0L2, Canada. [Bellin, Cheryl; Slezak, Brian] DuPont Haskell Global Centers Hlth & Environm Sci, Newark, DE USA. [Goodman, Jay I.] Michigan State Univ, Pharmcol & Toxicol, E Lansing, MI 48824 USA. [Jensen, Elke; Moretto, Angelo] Univ Milan, Dept Biomed & Clin Sci, Milan, Italy. [McMullin, Tami] Dow Corning Corp, Midland, MI USA. [Schoeny, Rita] US EPA, Washington, DC 20460 USA. [Wend, Korinna] Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA. [Wend, Korinna] Orthoped Hosp, Los Angeles, CA USA. [Wend, Korinna] Univ Calif Los Angeles, David Geffen Sch Med, Orthopaed Hosp Res Ctr, Los Angeles, CA 90095 USA. [Embry, Michelle R.] ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA. RP Embry, MR (reprint author), ILSI Hlth & Environm Sci Inst, 1156 15th St NW, Washington, DC 20005 USA. EM membry@hesiglobal.org OI Moretto, Angelo/0000-0003-4386-5736 NR 23 TC 2 Z9 2 U1 0 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD JAN 2 PY 2016 VL 46 IS 1 BP 43 EP 53 DI 10.3109/10408444.2015.1082973 PG 11 WC Toxicology SC Toxicology GA CZ1AD UT WOS:000366837100002 PM 26451723 ER PT J AU Doe, JE Lander, DR Doerrer, NG Heard, N Hines, RN Lowit, AB Pastoor, T Phillips, RD Sargent, D Sherman, JH Tanir, JY Embry, MR AF Doe, John E. Lander, Deborah R. Doerrer, Nancy G. Heard, Nina Hines, Ronald N. Lowit, Anna B. Pastoor, Timothy Phillips, Richard D. Sargent, Dana Sherman, James H. Tanir, Jennifer Young Embry, Michelle R. TI Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE Integrated testing strategy; pyrethroid; risk assessment; tiered approach ID 21ST-CENTURY ROADMAP; TOXICITY AB The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety. A case study of the use of a pyrethroid, pseudomethrin, in bed netting to control malaria is presented to demonstrate the application of the roadmap and matrix. The evaluation began with a problem formulation step. The first assessment utilized existing information pertaining to the use and the class of chemistry. At each stage of the step-wise approach, the precision of the toxicity and exposure estimates were refined as necessary by obtaining key data which enabled a decision on safety to be made efficiently and with confidence. The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach. The use of the matrix highlighted whether exposure or toxicity required further investigation and emphasized the need to address the default uncertainty factor of 100 at the highest tier of the evaluation. It also showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the use of the matrix. The matrix also serves as a useful means to communicate progress to stakeholders during an assessment of chemical use. C1 [Doe, John E.] Parker Doe Partnership LLP, Frodsham, Cheshire, England. [Lander, Deborah R.] DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE USA. [Doerrer, Nancy G.; Tanir, Jennifer Young; Embry, Michelle R.] ILSI Hlth & Environm Sci Inst, Washington, DC USA. [Heard, Nina; Pastoor, Timothy] Syngenta Crop Protect LLC, Greensboro, NC USA. [Hines, Ronald N.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. [Lowit, Anna B.] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. [Phillips, Richard D.] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Sargent, Dana] Arysta LifeSci North Amer, Cary, NC USA. [Sherman, James H.] Monsanto Co, St Louis, MO USA. RP Embry, MR (reprint author), ILSI Hlth & Environm Sci Inst, 1156 15th St,Suite 200, Washington, DC 20005 USA. EM membry@hesiglobal.org FU International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI); Syngenta FX This manuscript was prepared under the auspices of the International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI), a non-profit organization aimed at engaging scientists from academia, government, industry, research institutes, and NGOs to identify and resolve global health and environmental issues. The authors' affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views of the authors' employers or the opinions or policies of the US EPA or NIH. Mention of trade names does not constitute endorsement. None of the authors has recently or is currently involved as an expert witness in litigation or formal government rule making on the subject of this paper. The authors employed by ILSI HESI participated as part of their normal employment. None of the authors received financial support or an honorarium in the preparation of this paper, with the exception of Dr. John Doe whose work was supported by Syngenta. The authors declare that there are no conflicts of interest. NR 25 TC 1 Z9 1 U1 3 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD JAN 2 PY 2016 VL 46 IS 1 BP 54 EP 73 DI 10.3109/10408444.2015.1082974 PG 20 WC Toxicology SC Toxicology GA CZ1AD UT WOS:000366837100003 PM 26517449 ER PT J AU Suter, GW Cormier, SM AF Suter, Glenn W., II Cormier, Susan M. TI Bias in the development of health and ecological assessments and potential solutions SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE bias; ethics; environmental assessment; risk assessment; peer review; data quality ID REGULATORY FALSE POSITIVES; THRESHOLD LIMIT VALUES; IARC EVALUATION; ENVIRONMENTAL-HEALTH; RISK-ASSESSMENT; SCIENCE; INDUSTRY; POLICY; DEHP; SCIENTISTS AB The effectiveness and credibility of environmental decisions depend on the information provided by scientific assessments. However, the conflicting assessments provided by government agencies, industries, and environmental advocacy groups suggest that biases occur during assessment processes. Sources of bias include personal bias, regulatory capture, advocacy, reliance on volunteer assessors, biased stakeholder and peer review processes, literature searches, standardization of data, inappropriate standards of proof, misinterpretation, and ambiguity. Assessors can adopt practices to increase objectivity, transparency, and clarity. Decision-makers, managers of assessors, and institutions that commission assessments can adopt other practices that reduce pressures on assessors and reduce opportunities for expression of the personal biases of assessors. Environmental assessment should be recognized as a discipline with its own technical and ethical best practices. C1 [Suter, Glenn W., II; Cormier, Susan M.] US EPA, Cincinnati, OH 45268 USA. RP Suter, GW (reprint author), US EPA, 26 W Martin L King Dr, Cincinnati, OH 45268 USA. EM suter.glenn@epa.gov NR 84 TC 3 Z9 3 U1 0 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD JAN 2 PY 2016 VL 22 IS 1 BP 99 EP 115 DI 10.1080/10807039.2015.1056062 PG 17 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CX5BA UT WOS:000365714300008 ER PT J AU Wang, GD Nguyen, HT Chen, HM Cox, PB Wang, LC Nagata, K Hao, ZL Wang, A Li, ZB Xie, J AF Wang, Geoffrey D. Nguyen, Ha T. Chen, Hongmin Cox, Phillip B. Wang, Lianchun Nagata, Koichi Hao, Zhonglin Wang, Andrew Li, Zibo Xie, Jin TI X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy SO THERANOSTICS LA English DT Article DE photodynamic therapy; radiotherapy; lung cancer; clonogenecity; nanoparticles ID IONIZING-RADIATION; LUNG-CANCER; BASIC PRINCIPLES; HISTONE H2AX; DNA-DAMAGE; CELLS; NANOPARTICLES; APOPTOSIS; ONCOLOGY; CARCINOMA AB Conventional photodynamic therapy (PDT)' s clinical application is limited by depth of penetration by light. To address the issue, we have recently developed X-ray induced photodynamic therapy (X-PDT) which utilizes X-ray as an energy source to activate a PDT process. In addition to breaking the shallow tissue penetration dogma, our studies found more efficient tumor cell killing with X-PDT than with radiotherapy (RT) alone. The mechanisms behind the cytotoxicity, however, have not been elucidated. In the present study, we investigate the mechanisms of action of X-PDT on cancer cells. Our results demonstrate that X-PDT is more than just a PDT derivative but is essentially a PDT and RT combination. The two modalities target different cellular components (cell membrane and DNA, respectively), leading to enhanced therapy effects. As a result, X-PDT not only reduces short-term viability of cancer cells but also their clonogenecity in the long-run. From this perspective, X-PDT can also be viewed as a unique radiosensitizing method, and as such it affords clear advantages over RT in tumor therapy, especially for radioresistant cells. This is demonstrated not only in vitro but also in vivo with H1299 tumors that were either subcutaneously inoculated or implanted into the lung of mice. These findings and advances are of great importance to the developments of X-PDT as a novel treatment modality against cancer. C1 [Wang, Geoffrey D.; Chen, Hongmin; Xie, Jin] Univ Georgia, Dept Chem, Bioimaging Res Ctr, Athens, GA 30602 USA. [Nguyen, Ha T.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Cox, Phillip B.] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA. [Wang, Lianchun] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA. [Nagata, Koichi] Univ Georgia, Coll Vet Med, Athens, GA 30602 USA. [Hao, Zhonglin] Augusta Univ, Sect Hematol & Oncol, Med Coll Georgia, Georgia Canc Ctr, Augusta, GA 30912 USA. [Wang, Andrew] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Carolina Ctr Canc Nanotechnol Excellence, Lab Nano & Translat Med,Dept Radiat Oncol, Chapel Hill, NC USA. [Li, Zibo] Univ North Carolina Chapel Hill, Dept Radiol, Chapel Hill, NC USA. [Li, Zibo] Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr, Chapel Hill, NC USA. RP Chen, HM; Xie, J (reprint author), Univ Georgia, Dept Chem, Bioimaging Res Ctr, Athens, GA 30602 USA. EM hchen@uga.edu; jinxie@uga.edu FU DoD CDMRP grant [CA140666]; NSF CAREER grant [NSF1552617]; UGA-GRU seed grant; NIH P41 grant [GM103390] FX This research was supported by a DoD CDMRP grant (CA140666, J.X.), a NSF CAREER grant (NSF1552617, J.X.), a UGA-GRU seed grant (J.X.), and a NIH P41 grant support (GM103390, L.W.). NR 43 TC 2 Z9 2 U1 3 U2 3 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1838-7640 J9 THERANOSTICS JI Theranostics PY 2016 VL 6 IS 13 BP 2295 EP 2305 DI 10.7150/thno.16141 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EO2UN UT WOS:000396551600002 PM 27877235 ER PT S AU Prakash, N Stefanopoulou, AG Moskalik, AJ Brusstar, MJ AF Prakash, Niket Stefanopoulou, Anna G. Moskalik, Andrew J. Brusstar, Matthew J. GP IEEE TI Use of the Hypothetical Lead (HL) Vehicle Trace: A new method for Evaluating Fuel Consumption in Automated Driving SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council AB The regulation of fuel consumption and emissions around the world is based on standard drive (SD) cycles. Several autonomous or simple eco-driving methods of smoother driving and smaller acceleration and braking can violate the +/- 2 MPH speed deviation regulation from the SD and hence they are currently not counted towards the vehicle fuel economy, even though they are acceptable from a traffic pattern perspective, namely following a vehicle at a safe and reasonable gap. This paper develops and suggests a prototypical vehicle velocity versus time trajectory that supersedes each SD cycle since the SD cycle is the vehicle trace from following a vehicle with the prototypical velocity trace. The prototypical velocity trace is named from now on as the Hypothetical Lead (HL) vehicle cycle. In essence, the HL cycle recreates the traffic conditions followed by the drivers of the standard drive cycles. Finally, the paper concludes with a demonstration of using the HL cycle for assessing the fuel economy benefits of autonomous following in relation to standard test cycles and limits on the following distances to ensure that the different drive traces follow the same prototypical traffic conditions in a reasonable and safe way for real world applications. C1 [Prakash, Niket; Stefanopoulou, Anna G.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Moskalik, Andrew J.; Brusstar, Matthew J.] US EPA, Washington, DC 20460 USA. RP Prakash, N (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM niketpr@umich.edu; annastef@umich.edu; moskalik.andrew@epa.gov; brusstar.matt@epa.gov FU U.S. Environmental Protection Agency FX This work is supported by the U.S. Environmental Protection Agency NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 3486 EP 3491 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376103088 ER PT B AU Garcia, V Cooter, E Crooks, J Hayes, B Hinckley, B Murphy, M Wade, T Xing, XN AF Garcia, Valerie Cooter, Ellen Crooks, James Hayes, Brandon Hinckley, Brian Murphy, Mark Wade, Tim Xing, Xiangnan BE Steyn, DG Chaumerliac, N TI Using a Coupled Modelling System to Examine the Impacts of Increased Corn Production on Groundwater Quality and Human Health SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB Attributing nitrogen (N) in the environment to emissions from agricultural management practices is difficult because of the complex and inter-related chemical and biological reactions associated with N and its cascading effects across land, air and water. Such analyses are critical, however, in understanding the benefits and disbenefits associated with environmental management options. Coupled physical models present new opportunities to understand relationships among environmental variables across multiple sources, pathways and scenarios. Because they trace the environmental fate of pollutant concentrations found in the environment through first-principle physical and chemical processes, they shed new light on these complex interactions and how they will respond under various management scenarios. In this study, we use a coupled modeling system to holistically assess the impacts of increased corn production on groundwater and air quality. In particular, we show how the models provide new information on the drivers for contamination in groundwater and air, and then relate pollutant concentration changes attributed to potential changes in corn production between 2002 and 2022 to health and cost outcomes. C1 [Garcia, Valerie; Cooter, Ellen; Crooks, James; Wade, Tim] US EPA, Off Res & Dev, RTP, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Hayes, Brandon; Hinckley, Brian; Xing, Xiangnan] Oakridge Natl Lab, ORISE, Oak Ridge, TN USA. [Murphy, Mark] Innovate Inc, Alexandria, VA USA. RP Garcia, V (reprint author), US EPA, Off Res & Dev, RTP, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM garcia.val@epa.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 113 EP 117 DI 10.1007/978-3-319-24478-5_18 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100019 ER PT B AU Napelenok, SL Luecken, D AF Napelenok, Sergey L. Luecken, Deborah BE Steyn, DG Chaumerliac, N TI Sensitivity-Based VOC Reactivity Calculation SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada ID ORGANIC-COMPOUNDS AB Volatile Organic Compound (VOC) reactivity scales are used to compare the ozone-forming potentials of various compounds. The comparison allows for substitution of compounds to lessen formation of ozone from paints, solvents, and other products. Current reactivity scales for VOC compounds were first developed using 1-D trajectory/box models for short pollution episodes several decades ago. In this study, they are updated using the 3-D air quality model CMAQ instrumented with DDM-3D. DDM-3D sensitivities are used to update relative reactivity metrics of a number of VOCs over more meaningful timescales. Using sensitivity calculation in the context of an air quality model for reactivity calculations avoids the issues of trajectory assumptions inherent in the 1-D calculations and allow for calculation of regional representative metrics. C1 [Napelenok, Sergey L.; Luecken, Deborah] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. RP Napelenok, SL (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. EM napelenok.sergey@epa.gov NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 233 EP 237 DI 10.1007/978-3-319-24478-5_38 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100039 ER PT B AU Mathur, R Xing, J Napelenok, S Pleim, J Hogrefe, C Wong, D Gan, CM Kang, DW AF Mathur, Rohit Xing, Jia Napelenok, Sergey Pleim, Jonathan Hogrefe, Christian Wong, David Gan, Chuen-Meei Kang, Daiwen BE Steyn, DG Chaumerliac, N TI Multiscale Modeling of Multi-decadal Trends in Ozone and Precursor Species Across the Northern Hemisphere and the United States SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB Multi-decadal model calculations for the 1990-2010 period are performed with the coupled WRF-CMAQ modeling system over a domain encompassing the northern hemisphere and a nested domain over the continental U.S. Simulated trends in ozone and precursor species concentrations across the U.S. over the past two decades are compared with those inferred from available measurements during this period. The model results suggest large and contrasting changes in tropospheric composition over the northern hemisphere with significant reductions in air pollution over North America and Western Europe and increase in large portions of Asia. The model is able to capture the changing seasonal distributions in surface O-3 in the U.S. during 1990-2010 arising from changing emissions and long-range transport. C1 [Mathur, Rohit; Xing, Jia; Napelenok, Sergey; Pleim, Jonathan; Hogrefe, Christian; Wong, David; Gan, Chuen-Meei] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. [Kang, Daiwen] Comp Sci Corp, RTP, Durham, NC USA. RP Mathur, R (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. EM napelenok.sergey@epa.gov NR 6 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 239 EP 243 DI 10.1007/978-3-319-24478-5_39 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100040 ER PT B AU Hogrefe, C Pouliot, G Xing, J Flemming, J Roselle, S Mathur, R Galmarini, S AF Hogrefe, Christian Pouliot, George Xing, Jia Flemming, Johannes Roselle, Shawn Mathur, Rohit Galmarini, Stefano BE Steyn, DG Chaumerliac, N TI Global and Regional Modeling of Long-Range Transport and Intercontinental Source-Receptor Linkages SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada ID SYSTEM AB In this study, we compare air quality over North America simulated by the C-IFS global model and the CMAQ regional model driven by boundary conditions from C-IFS against surface and upper air observations. Results indicate substantial differences in model performance for surface ozone between the two models. Above the boundary layer, differences are least pronounced in the free troposphere but increase in the upper troposphere and lower stratosphere. In addition, we also compare the impacts of perturbed emissions in East Asia and North America on air quality over North America simulated by CMAQ and C-IFS. C1 [Hogrefe, Christian; Pouliot, George; Xing, Jia; Roselle, Shawn; Mathur, Rohit] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. [Flemming, Johannes] European Ctr Medium Range Weather Forecasts, Reading, Berks, England. [Galmarini, Stefano] European Commiss Joint Res Ctr, Ispra, Italy. RP Hogrefe, C (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. EM hogrefe.christian@epa.gov NR 6 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 245 EP 250 DI 10.1007/978-3-319-24478-5_40 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100041 ER PT B AU Isakov, V Barzyk, T Arunachalam, S Snyder, M Venkatram, A AF Isakov, Vlad Barzyk, Timothy Arunachalam, Saravanan Snyder, Michelle Venkatram, Akula BE Steyn, DG Chaumerliac, N TI A Community-Scale Modeling System to Assess Port-Related Air Quality Impacts SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB Near-port air pollution has been identified by numerous organizations as a potential public health concern. Based upon multiple near-road and near-source monitoring studies, both busy roadways and large emission sources at the ports may impact local air quality within several hundred meters of the ports. As the volume of trucking and freight movement increases, near-road air quality along transportation routes could be affected well outside port boundaries. Health effects have been associated with near-road exposures and proximity to large emission sources, so characterizing emission sources is important for understanding potential health effects. To address this need, we have developed a new community-scale tool called C-PORT to model emissions related to all port-related activities-including, but not limited to ships, trucks, cranes, etc.-and predict concentrations at fine spatial scales in the near-source environment. C-PORT represents one of the first efforts to develop a reduce-form modeling system that is optimized for community-scale applications. The modeling system includes dispersion algorithms for area, point, and line sources related to port activities, and emissions from the port terminals. The use of the reduced-form approach in C-PORT enables us to examine what-if scenarios of changes in emission volume, such as due to changes in traffic counts, fleet mix, speed, or in port emissions due to equipment or vehicles in near real-time, using a web-based easy-to-use interface. The C-PORT model can be used to examine different scenarios of air quality impacts in order to identify potentially at-risk populations located near emission sources, and the effects that port expansion may have on them. We present an illustrative example of the near-port modeling assessment focusing on the Port of Charleston in South Carolina, USA, to complement a field-study that was conducted during spring 2014 to take air quality measurements in residential neighborhoods in the port vicinity. C1 [Isakov, Vlad] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. [Barzyk, Timothy] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Durham, NC USA. [Arunachalam, Saravanan; Snyder, Michelle] Univ N Carolina, Inst Environm, Chapel Hill, NC USA. [Venkatram, Akula] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. RP Isakov, V (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, RTP, Durham, NC 27709 USA. EM Isakov.Vlad@epa.gov NR 3 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 385 EP 390 DI 10.1007/978-3-319-24478-5_63 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100064 ER PT B AU Pleim, J Gilliam, R Appel, W Ran, L AF Pleim, Jonathan Gilliam, Robert Appel, Wyat Ran, Limei BE Steyn, DG Chaumerliac, N TI Recent Advances in Modeling of the Atmospheric Boundary Layer and Land Surface in the Coupled WRF-CMAQ Model SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada ID NONLOCAL CLOSURE-MODEL AB Advances in the land surface model (LSM) and planetary boundary layer (PBL) components of the WRF-CMAQ coupled meteorology and air quality modeling system are described. The aim of these modifications was primarily to improve the modeling of ground level concentrations of trace chemical species such as nitrogen oxides (NOx), carbon monoxide (CO), particulate matter (PM), and ozone (O-3) during the evening transition and overnight. However, evaluation of both meteorological and air quality quantities shows that the advanced algorithms added to the PX LSM and the ACM2 PBL schemes improved results both day and night. Modeling experiments at various grid spacings (1, 4, and 12 km) and for different years and seasons all show significant improvements. The revised versions of these components have already been released in WRFv3.7 and will be released in the fall of 2015 in CMAQv5.1. C1 [Pleim, Jonathan; Gilliam, Robert; Appel, Wyat] US EPA, Atmospher Modeling & Anal Div, Durham, NC 27711 USA. [Ran, Limei] Univ N Carolina, Inst Environm, Chapel Hill, NC 27599 USA. RP Pleim, J (reprint author), US EPA, Atmospher Modeling & Anal Div, Durham, NC 27711 USA. EM Pleim.jon@epa.gov NR 8 TC 2 Z9 2 U1 2 U2 2 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 391 EP 396 DI 10.1007/978-3-319-24478-5_64 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100065 ER PT B AU Wong, DC Cai, C Pleim, J Mathur, R Murphy, MS AF Wong, David C. Cai, Chenxia Pleim, Jonathan Mathur, Rohit Murphy, Mark S. BE Steyn, DG Chaumerliac, N TI Validation of the WRF-CMAQ Two-Way Model with Aircraft Data and High Resolution MODIS Data in the CA 2008 Wildfire Case SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB A new WRF-CMAQ two-way coupled model was developed to provide a pathway for chemical feedbacks from the air quality model to the meteorological model. The essence of this interaction is focused on the direct radiative effects of scattering and absorbing aerosols in the troposphere that in turn affect radiation calculations in the meteorological model, WRF. We tested this two-way coupled model with a high aerosol loading episode resulting from a wildfire outbreak in California in June 2008. We evaluate various aspects of the model with traditional statistical approaches, a comparison with radiation measurements, and AOD measurements from high resolution (500 m) MODIS data. C1 [Wong, David C.; Pleim, Jonathan; Mathur, Rohit; Murphy, Mark S.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Cai, Chenxia] Calif Air Resources Board, Sacramento, CA USA. RP Wong, DC (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM wong.david-c@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The 500 m high resolution MODIS data was obtained from Mr. Steve Reid of Sonomatech. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency's administrative review and approved for publication. Although it has been reviewed by EPA and approved for publication, it does not necessarily reflect their policies or views. NR 1 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 531 EP 535 DI 10.1007/978-3-319-24478-5_85 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100086 ER PT B AU Porter, PS Rao, ST Hogrefe, C Gego, E Mathur, R AF Porter, P. Steven Rao, S. T. Hogrefe, Christian Gego, Edith Mathur, Rohit BE Steyn, DG Chaumerliac, N TI Metamodels for Ozone: Comparison of Three Estimation Techniques SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB A metamodel for ozone is a mathematical relationship between the inputs and outputs of an air quality modeling experiment, permitting calculation of outputs for scenarios of interest without having to run the model again. In this study we compare three metamodel estimation techniques applied to an 18 year long CMAQ simulation covering the Northeastern US (NEUS). The estimation methods considered here include projection onto latent structures, stochastic kriging and a combination of principal components and stochastic kriging. C1 [Porter, P. Steven; Gego, Edith] Porter Gego, Idaho Falls, ID 83401 USA. [Rao, S. T.] North Carolina State Univ, Raleigh, NC 27695 USA. [Hogrefe, Christian; Mathur, Rohit] US EPA, AMAD NERL, Durham, NC USA. RP Porter, PS (reprint author), Porter Gego, Idaho Falls, ID 83401 USA. EM psp@srv.net FU Coordinating Research Council [A-89] FX This work was made possible by Coordinating Research Council contract A-89. NR 3 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 537 EP 542 DI 10.1007/978-3-319-24478-5_86 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100087 ER PT B AU Stajner, I Lee, P McQueen, J Draxler, R Dickerson, P Upadhayay, S AF Stajner, Ivanka Lee, Pius McQueen, Jeffery Draxler, Roland Dickerson, Phil Upadhayay, Sikchya BE Steyn, DG Chaumerliac, N TI Update on NOAA's Operational Air Quality Predictions SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada ID CAPABILITY; SYSTEM; MODEL AB NOAA provides operational predictions of ozone and wildfire smoke for the United States (U.S.) and predictions of airborne dust over the contiguous 48 states. Predictions are produced beyond midnight of the following day at 12 km spatial and hourly temporal resolution and are available at http:// airquality. weather. gov/. Ozone predictions and testing of fine particulate matter (PM2.5) predictions combine the NOAA National Centers for Environmental Prediction (NCEP) operational North American Mesoscale (NAM) weather predictions with inventory based emission estimates from the EPA and chemical processes within the Community Multiscale Air Quality (CMAQ) model. Predictions of smoke and dust from dust storms use the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model. Verification of ozone and developmental aerosol predictions relies on AIRNow compilation of observations from surface monitors. Verification of smoke and dust predictions uses satellite retrievals of smoke and dust. Ozone prediction accuracy is maintained in recent years, while pollution sources are changing, through updates in emission source estimates and updates in the model configuration. Emissions for operational ozone predictions were updated using EPA projections of mobile sources for 2012. Trends in NOx from satellite and ground observations show a good agreement with emission updates over large U.S. cities. Updated CMAQ model with CB05 mechanism and AERO4 aerosol module was implemented for operational ozone prediction in January 2015. Updates include monthly varying lateral boundary conditions, modified dry deposition, constraints on minimum planetary boundary height, and changes to the lifetime of organic nitrate. Testing of PM2.5 predictions from the same system modulates soil emissions by snow and ice cover, and includes emissions of windblown dust and particles emitted from forest fires. Further development of PM2.5 predictions will explore bias correction approaches. Longer-term plans include comprehensive linkages between NAQFC predictions for the U.S. and global atmospheric composition predictions, as resources allow. C1 [Stajner, Ivanka; Lee, Pius; McQueen, Jeffery; Draxler, Roland; Upadhayay, Sikchya] NOAA, Washington, DC 20230 USA. [Dickerson, Phil] US EPA, Washington, DC 20460 USA. [Upadhayay, Sikchya] Syneren Technol Corp, Arlington, VA USA. RP Stajner, I (reprint author), NOAA, Washington, DC 20230 USA. EM ivanka.stajner@noaa.gov NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 593 EP 597 DI 10.1007/978-3-319-24478-5_96 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100097 ER PT B AU Ran, LM Pleim, J Gilliam, R Hogrefe, C Binkowski, F Band, L AF Ran, Limei Pleim, Jonathan Gilliam, Robert Hogrefe, Christian Binkowski, Frank Band, Larry BE Steyn, DG Chaumerliac, N TI Application and Evaluation of MODIS LAI, FPAR, and Albedo Products in the WRF/CMAQ System SO AIR POLLUTION MODELING AND ITS APPLICATION XXIV SE Springer Proceedings in Complexity LA English DT Proceedings Paper CT 34th International Technical Meeting on Air Pollution Modelling and its Application (ITM) CY MAY 04-08, 2015 CL Montpellier, FRANCE SP LaMP OPGC, CNRS, Univ British Columbia, CNRS INSU, CEA, CNES, ADEME, INERIS, Environm Canada AB MODIS vegetation and albedo products provide a more realistic representation of surface conditions for input to the WRF/CMAQ modeling system. However, the initial evaluation of ingesting MODIS data into the system showed mixed results, with increased bias and error for 2-m temperature and reduced bias and error for 2-m mixing ratio. Recently, the WRF/CMAQ land surface and boundary layer processes have been updated. In this study, MODIS vegetation and albedo data are input to the updated WRF/CMAQ meteorology and air quality simulations for 2006 over a North American (NA) 12-km domain. The evaluation of the simulation results shows that the updated WRF/CMAQ system improves 2-m temperature estimates over the pre-update base modeling system estimates. The MODIS vegetation input produces a realistic spring green-up that progresses through time from the south to north. Overall, MODIS input reduces 2-m mixing ratio bias during the growing season. The NA west shows larger positive O-3 bias during the growing season because of reduced gas phase deposition resulting from lower O-3 deposition velocities driven by reduced vegetation cover. The O-3 bias increase associated with the realistic vegetation representation indicates that further improvement may be needed in the WRF/CMAQ system. C1 [Ran, Limei; Binkowski, Frank; Band, Larry] Univ N Carolina, Inst Environm, Chapel Hill, NC USA. [Pleim, Jonathan; Gilliam, Robert; Hogrefe, Christian] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. RP Ran, L (reprint author), Univ N Carolina, Inst Environm, Chapel Hill, NC USA. EM Iran@unc.edu NR 6 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND BN 978-3-319-24476-1; 978-3-319-24478-5 J9 SPRINGER PR COMPLEX PY 2016 BP 619 EP 624 DI 10.1007/978-3-319-24478-5_100 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BG9SQ UT WOS:000393786100101 ER PT J AU Odeyingbo, O Nnorom, I Deubzer, O Kuhr, R Osibanjo, O Onianwa, P Adie, G Adrian, S Willke, K AF Odeyingbo, Olusegun Nnorom, Innocent Deubzer, Otmar Kuehr, Ruediger Osibanjo, Oladele Onianwa, Percy Adie, Gilbert Adrian, Stephanie Willke, Klaus GP IEEE TI The Person-in-the-Port Project: Volumes and Quality of Used Electronics Imports into Nigeria SO 2016 ELECTRONICS GOES GREEN 2016+ (EGG) LA English DT Proceedings Paper CT Conference on Electronics Goes Green (EGG) CY SEP 07-09, 2016 CL Berlin, GERMANY SP Fraunhofer Inst Reliabil & Microintegrat IZM, Technische Univ Berlin AB Exports of used electrical and electronic equipment (UEEE) from richer countries and into developing countries provide socio-economic benefits, but also contribute to the huge environmental and health damages e-waste causes in these countries. Nigeria is a hub of UEEE imports into Africa. To obtain a realistic picture about volumes, types and quality of UEEE imports, the "Person-in-the-Port" (PiP) project installed an expert in the main ports of Lagos to inspect incoming containers for UEEE and evaluate importation-related documentation. The project is ongoing and final results are not yet available. The paper describes the project approach, the specific problems encountered and first insights into the UEEE export/import business. C1 [Odeyingbo, Olusegun; Deubzer, Otmar; Kuehr, Ruediger] United Nations Univ, Shibuya, Tokyo, Japan. [Nnorom, Innocent; Osibanjo, Oladele; Onianwa, Percy; Adie, Gilbert] BCCC Africa, Ibadan, Nigeria. [Adrian, Stephanie] US EPA, Washington, DC 20460 USA. [Willke, Klaus] Senior Expert Serv, Hamburg, Germany. RP Odeyingbo, O (reprint author), United Nations Univ, Shibuya, Tokyo, Japan. NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-3-00-053763-9 PY 2016 PG 8 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Electrical & Electronic SC Science & Technology - Other Topics; Engineering GA BG9QG UT WOS:000393598400034 ER PT J AU Shen, YH Pham, AK Davis, B Smiley-Jewell, S Wang, L Kodavanti, UP Takeuchi, M Tancredi, DJ Pinkerton, KE AF Shen, Yi-Hsin Pham, Alexa K. Davis, Benjamin Smiley-Jewell, Suzette Wang, Lei Kodavanti, Urmila P. Takeuchi, Minoru Tancredi, Daniel J. Pinkerton, Kent E. TI Sex and strain-based inflammatory response to repeated tobacco smoke exposure in spontaneously hypertensive and Wistar Kyoto rats SO INHALATION TOXICOLOGY LA English DT Article DE Lung inflammation; neutrophils; spontaneously hypertensive rats; tobacco smoke ID OBSTRUCTIVE PULMONARY-DISEASE; INDUCED LUNG INFLAMMATION; NECROSIS-FACTOR-ALPHA; AIRWAY INFLAMMATION; SEVERE EXACERBATIONS; OXIDATIVE STRESS; INDUCED SPUTUM; ANIMAL-MODELS; COPD; EXPRESSION AB Context: Approximately four million people die every year from chronic obstructive pulmonary disease (COPD), with more than 80% of the cases attributed to smoking. Object: The purpose of this study was to examine the rat strain and sex-related differences and the extended tobacco smoke exposure to induce lung injury and inflammation with the goal of finding a suitable rodent model to study COPD. Methods: Male and female spontaneously hypertensive (SH) and male Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or to tobacco smoke (TS: 90 mg/m(3) particulate concentration) for 6 h/day, three days/week for 4 or 12 weeks. Results: Male SH rats demonstrated an enhanced, persistent inflammatory response compared to female SH and male WKY rats with extended TS exposure. Following four weeks of TS exposure, male SH rats had significantly increased total leukocytes and macrophage numbers, levels of TNF-alpha and elevated lactate dehydrogenase activity in bronchoalveolar lavage fluid compared with female SH, male WKY rats and corresponding controls. After 12 weeks of TS exposure, male SH rats continued to show significant increase in inflammatory cells and TNF-alpha, as well as IL-6 mRNA lung expression. In addition, the alveolar airspace of male SH rats exposed to TS was significantly enlarged compared to their FA controls, female SH and WKY rats. Conclusion: The male SH rat demonstrates greater cellular, inflammatory and structural changes highly reminiscent of COPD compared to female SH and male WKY rats, suggesting that the male SH rat is an optimal rodent model to study COPD. C1 [Shen, Yi-Hsin; Pham, Alexa K.; Davis, Benjamin; Smiley-Jewell, Suzette; Wang, Lei; Pinkerton, Kent E.] Univ Calif Davis, Ctr Hlth & Environm, One Shields Ave, Davis, CA 95616 USA. [Kodavanti, Urmila P.] US EPA, Cardiopulm & Immunotoxicol Branch, Natl Hlth & Environm Effects Res Lab, Off Res & Dev,Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Takeuchi, Minoru] Kyoto Sangyo Univ, Dept Anim Sci, Kyoto, Japan. [Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA. [Tancredi, Daniel J.] Univ Calif Davis, Ctr Healthcare Policy & Res, Davis, CA 95616 USA. RP Pinkerton, KE (reprint author), Univ Calif Davis, Ctr Hlth & Environm, One Shields Ave, Davis, CA 95616 USA. EM kepinkerton@ucdavis.edu FU Office of Research at the University of California, Davis; UC Davis [T32HL007013] FX The authors report no conflicts of interest. This research was supported by funds through the Office of Research at the University of California, Davis and the UC Davis T32 Comparative Training in Lung Biology and Medicine [T32HL007013] (YHS, AKP). NR 45 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2016 VL 28 IS 14 BP 677 EP 685 DI 10.1080/08958378.2016.1249812 PG 9 WC Toxicology SC Toxicology GA EJ1KC UT WOS:000392968000004 PM 27829308 ER PT J AU Ghio, AJ Soukup, JM Dailey, LA Richards, JH Tong, HY AF Ghio, Andrew J. Soukup, Joleen M. Dailey, Lisa A. Richards, Judy H. Tong, Haiyan TI The biological effect of asbestos exposure is dependent on changes in iron homeostasis SO INHALATION TOXICOLOGY LA English DT Article DE asbestos; ferritin; inflammation; iron; oxidants ID EPITHELIAL-CELLS; OXIDATIVE STRESS; HUMAN LUNG; MITOCHONDRIA; SUPEROXIDE; ACCUMULATION; METABOLISM; ACTIVATION; EXPRESSION; GENERATION AB Functional groups on the surface of fibrous silicates can complex iron. We tested the postulate that (1) asbestos complexes and sequesters host cell iron resulting in a disruption of metal homeostasis and (2) this loss of essential metal results in an oxidative stress and biological effect in respiratory epithelial cells. Exposure of BEAS-2B cells to 50 mu g/mL chrysotile resulted in diminished concentrations of mitochondrial iron. Preincubation of these cells with 200 mu M ferric ammonium citrate (FAC) prevented significant mitochondrial iron loss following the same exposure. The host response to chrysotile included increased expression of the importer divalent metal transporter-1 (DMT1) supporting a functional iron deficiency. Incubation of BEAS-2B cells with both 200 mu M FAC and 50 mu g/mL chrysotile was associated with a greater cell accumulation of iron relative to either iron or chrysotile alone reflecting increased import to correct metal deficiency immediately following fiber exposure. Cellular oxidant generation was elevated after chrysotile exposure and this signal was diminished by co-incubation with 200 mu M FAC. Similarly, exposure of BEAS-2B cells to 50 mu g/mL chrysotile was associated with release of the proinflammatory mediators interleukin (IL)-6 and IL-8, and these changes were diminished by co-incubation with 200 mu M FAC. We conclude that (1) the biological response following exposure to chrysotile is associated with complexation and sequestration of cell iron and (2) increasing available iron in the cell diminished the effects of asbestos exposure. C1 [Ghio, Andrew J.; Soukup, Joleen M.; Dailey, Lisa A.; Richards, Judy H.; Tong, Haiyan] US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. RP Ghio, AJ (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM ghio.andy@epa.gov NR 31 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2016 VL 28 IS 14 BP 698 EP 705 DI 10.1080/08958378.2016.1257665 PG 8 WC Toxicology SC Toxicology GA EJ1KC UT WOS:000392968000006 PM 27884072 ER PT J AU Momm, HG Bingner, RL Yuan, Y Kostel, J Monchak, JJ Locke, MA Gilley, A AF Momm, H. G. Bingner, R. L. Yuan, Y. Kostel, J. Monchak, J. J. Locke, M. A. Gilley, A. TI CHARACTERIZATION AND PLACEMENT OF WETLANDS FOR INTEGRATED CONSERVATION PRACTICE PLANNING SO Transactions of the ASABE LA English DT Article DE GIS; Precision conservation; Topographic analysis; Watershed modeling; Wetland ID CONSTRUCTED WETLANDS; WATER; DENITRIFICATION; ECOSYSTEMS; RETENTION; FRAMEWORK; NITROGEN; REMOVAL AB Constructed wetlands have been recognized as an efficient and cost-effective conservation practice to protect water quality through reducing the transport of sediments and nutrients from upstream croplands to downstream water bodies. The challenge resides in targeting the strategic location of wetlands within agricultural watersheds to maximize the reduction in nutrient loads while minimizing their impact on crop production. Furthermore, agricultural watersheds involve complex interrelated processes requiring a systems approach to evaluate the inherent relationships between wetlands and multiple sediment/nutrient sources (sheet, rill, ephemeral gully, channels) and other conservation practices (filter strips). This study describes new capabilities of the USDA's Annualized Agricultural Non-Point Source pollutant loading model, AnnAGNPS. A developed AnnAGNPS GIS-based wetland component, AgWet, is introduced to identify potential sites and characterize individual artificial or natural wetlands at a watershed scale. AgWet provides a simplified, semi-automated, and spatially distributed approach to quantitatively evaluate wetlands as potential conservation management alternatives. AgWet is integrated with other AnnAGNPS components providing seamless capabilities of estimating the potential sediment/nutrient reduction of individual wetlands. This technology provides conservationists the capability for improved management of watershed systems and support for nutrient credit trading programs. C1 [Momm, H. G.; Gilley, A.] Middle Tennessee State Univ, Dept Geosci, Murfreesboro, TN 37130 USA. [Bingner, R. L.; Locke, M. A.] USDA ARS, Natl Sedimentat Lab, Oxford, MS 38655 USA. [Yuan, Y.] US EPA, Las Vegas, NV 89193 USA. [Kostel, J.; Monchak, J. J.] Wetlands Initiat, Chicago, IL USA. RP Momm, HG (reprint author), 322G Kirksey Old Main,MTSU Box 9, Murfreesboro, TN 37132 USA. EM henrique.momm@mtsu.edu NR 30 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 2151-0032 EI 2151-0040 J9 T ASABE JI Trans. ASABE PY 2016 VL 59 IS 5 BP 1345 EP 1357 DI 10.13031/trans.59.11635 PG 13 WC Agricultural Engineering SC Agriculture GA EJ0VP UT WOS:000392929300032 ER PT J AU Raith, M Zacherl, DC Pilgrim, EM Eernisse, DJ AF Raith, Meredith Zacherl, Danielle C. Pilgrim, Erik M. Eernisse, Douglas J. TI Phylogeny and species diversity of Gulf of California oysters (Ostreidae) inferred from mitochondrial DNA SO AMERICAN MALACOLOGICAL BULLETIN LA English DT Article; Proceedings Paper CT Symposium on Bivalvia of the Americas / 79th Annual Meeting of the American-Malacological-Society in conjunction with the Society-of-Malacology-of-Mexico, the Latinoamerican-Society-of-Malacology, and the Western-Society-of-Malacologists CY JUN 24-25, 2014 CL Mexico City, MEXICO SP Amer Malacol Soc, Soc Malacol Mexico, Latinoamerican Soc Malacol, Western Soc Malacologists DE systematics; Ostrea; Crassostrea; Saccostrea; phylogeography ID CRASSOSTREA-CORTEZIENSIS; MOLECULAR PHYLOGENY; OSTREOLA-EQUESTRIS; WASHINGTON-STATE; BAJA-CALIFORNIA; OLYMPIA OYSTER; HONG-KONG; BIVALVIA; PACIFIC; GRYPHAEIDAE AB The Olympia oyster, Ostrea lurida Carpenter, 1864, is the only native oyster on the west coast of temperate western North America and a conservation target for native species restoration throughout much of its known range, from British Columbia, Canada to Baja California, Mexico. This species was recently demonstrated to be genetically distinct from its southern congener, O. conchaphila Carpenter, 1857, but our new sampling, combined with previously published data, supports a tentative allopatric pattern, with the southern and northern species restricted to either side of Punta Eugenia in Baja California, Mexico, a known biogeographic boundary. We collected O. conchaphila and multiple co-occurring oyster species at 11 sites along the Pacific coast of Baja California Sur or within the Gulf of California, Mexico. Oyster surveys revealed at least six other co-occurring species, including two exotics, of Ostreidae Rafinesque, 1815 that were identified by sequencing 16S ribosomal DNA (16S) and cytochrome oxidase subunit 1 (COI) mitochondrial markers. In addition to our newly collected material, our phylogenetic analyses included Ostreidae from worldwide localities available in GenBank. Phylogenetic estimates, using maximum likelihood, supported the sister species relationship between Ostrea lurida Carpenter, 1864 and O. conchaphila Carpenter, 1857. Together, they group as the sister lineage of Myrakeena angelica (Rochebrune, 1895), nested within a grouping of species currently assigned to Ostrea Linnaeus, 1758. Thus, we have revived the original name Ostrea angelica Rochebrune, 1895 and consider the monotypic genus, Myrakeena Harry, 1985 a junior synonym of Ostrea. We also collected O. equestris Say, 1834, native to the Caribbean and not previously reported in the Eastern Pacific. Our results are consistent with the recognition of only four subfamilies within Ostreidae: Ostreinae Rafinesque, 1815, Crassostreinae Scarlato and Starobogatov, 1979, Saccostreinae Salvi etal., 2014, and Striostreinae new subfamily. Another subfamily, Lophinae Vialov, 1936, is best synonymized with Ostreinae because it would otherwise be paraphyletic to that taxon. Sequences of Saccostrea palmula (Carpenter, 1857) revealed a striking lack of genetic variation that contrasted with their substantial phenotypic plasticity. Surprisingly: the morphologically distinctive species, Ostrea tubulifera Dalt, 1914, was revealed as an ecotype of S. pair-unlit, and so is herein considered a junior synonym of the latter species. C1 [Raith, Meredith; Zacherl, Danielle C.; Eernisse, Douglas J.] Calif State Univ Fullerton, Dept Biol Sci, Fullerton, CA 92834 USA. [Pilgrim, Erik M.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Eernisse, DJ (reprint author), Calif State Univ Fullerton, Dept Biol Sci, Fullerton, CA 92834 USA. EM deernisse@fullerton.edu NR 97 TC 0 Z9 0 U1 1 U2 1 PU AMER MALACOLOGICAL SOC, INC PI WILMINGTON PA DELAWARE MUSEUM NATURAL HISTORY, BOX 3937, WILMINGTON, DE 19807-0937 USA SN 0740-2783 EI 2162-2698 J9 AM MALACOL BULL JI Am. Malacol. Bull. PD JAN PY 2016 VL 33 IS 2 BP 263 EP 283 PG 21 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA DA8IN UT WOS:000368048400011 ER PT S AU Kukulya, AL Bellingham, JG Kaeli, JW Reddy, CM Godin, MA Conmy, RN AF Kukulya, A. L. Bellingham, J. G. Kaeli, J. W. Reddy, C. M. Godin, M. A. Conmy, R. N. GP IEEE TI Development of a Propeller Driven Long Range Autonomous Underwater Vehicle (LRAUV) for Under-Ice Mapping of Oil Spills and Environmental Hazards An Arctic Domain Center of Awareness Project (ADAC) SO 2016 IEEE/OES AUTONOMOUS UNDERWATER VEHICLES (AUV) SE IEEE OES Autonomous Underwater Vehicles LA English DT Proceedings Paper CT IEEE/OES Autonomous Underwater Vehicles (AUV) Workshop CY NOV 06-09, 2016 CL Univ Tokyo, Inst Ind Sci, Tokyo, JAPAN SP IEEE Ocean Engn Soc, IEEE Ocean Engn Soc, Japan Chapter, Minist Educ Culture Sports Sci & Technol, Soc Underwater Technol HO Univ Tokyo, Inst Ind Sci DE LRAUV; Tethys; ADAC; Oil Spill; Arctic; Ice ID AUV NAVIGATION; SYSTEM AB The increasing level of commercial marine activity in high latitudes creates an ever growing risk of oil spills. Even in logistically accessible, ice-free oceans, characterizing the extent and nature of a spill can be challenging as highlighted by the Deepwater Horizon incident. We propose to develop an AUV-based approach inspired by an existing small, long-range system, called the Tethys Long-Range AUV (LRAUV), in order to support the Arctic Doman Awareness Center (ADAC) for spill preparedness. C1 [Kukulya, A. L.; Bellingham, J. G.; Kaeli, J. W.; Reddy, C. M.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Godin, M. A.] IntuAware, Northampton, MA USA. [Conmy, R. N.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Kukulya, AL (reprint author), Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. EM akukulya@whoi.edu NR 23 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3167 BN 978-1-5090-2442-1 J9 IEEE AUTO UNDER VEH PY 2016 BP 95 EP 100 PG 6 WC Engineering, Ocean; Robotics SC Engineering; Robotics GA BG6WC UT WOS:000390848000018 ER PT J AU Ghio, A Schreinemachers, D AF Ghio, A. Schreinemachers, D. TI Heme Oxygenase Activity Correlates With Serum Indices Of Iron Homeostasis In Healthy Non-Smokers SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Ghio, A.; Schreinemachers, D.] US EPA, Chapel Hill, NC USA. EM ghio.andy@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A5448 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749605111 ER PT J AU Ghio, A Case, M Soukup, J AF Ghio, A. Case, M. Soukup, J. TI Heme Oxygenase Activity Increases After Exercise In Healthy Volunteers SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Ghio, A.; Case, M.; Soukup, J.] US EPA, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A5447 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749605110 ER PT J AU Ghio, A Soukup, J Dailey, L Shen, Z Kantrow, S AF Ghio, A. Soukup, J. Dailey, L. Shen, Z. Kantrow, S. TI Particle Exposure Impacts Iron Homeostasis In Alveolar Macrophages SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Ghio, A.; Soukup, J.; Dailey, L.] US EPA, Chapel Hill, NC USA. [Shen, Z.; Kantrow, S.] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. EM ghio.andy@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A1202 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749600202 ER PT J AU Hooper, LG Young, MT Keller, JP Szpiro, A O'Brien, KM Sandler, DP Vedal, S Kaufman, J London, S AF Hooper, L. G. Young, M. T. Keller, J. P. Szpiro, A. O'Brien, K. M. Sandler, D. P. Vedal, S. Kaufman, J. London, S. TI Ambient Air Pollution Exposure And Chronic Bronchitis In A Cohort Of U. S. Women SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Hooper, L. G.; Young, M. T.; Keller, J. P.; Szpiro, A.; Vedal, S.; Kaufman, J.] Univ Washington, Seattle, WA 98195 USA. [O'Brien, K. M.; Sandler, D. P.; London, S.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. EM lghooper@uw.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A2991 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749602239 ER PT J AU Perkins, TN Poulsen, ET Enghild, JJ Ghio, A Roggli, V Oury, TD AF Perkins, T. N. Poulsen, E. Toftgaard Enghild, J. J. Ghio, A. Roggli, V. Oury, T. D. TI Determination Of Asbestos Body-Associated Proteins By Laser Scanning Micro-Dissection And Mass Spectrometry SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Perkins, T. N.; Oury, T. D.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Poulsen, E. Toftgaard; Enghild, J. J.] Aarhus Univ, Aarhus, Denmark. [Ghio, A.] US EPA, Chapel Hill, NC USA. [Roggli, V.] Duke Univ, Med Ctr, Durham, NC USA. EM tnperkins@pitt.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A4116 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749603499 ER PT J AU Walsh, DM McCullough, SD Yourstone, S Kahle, JJ Jones, SW Jones, CD Jaspers, I Diaz-Sanchez, D AF Walsh, D. M. McCullough, S. D. Yourstone, S. Kahle, J. J. Jones, S. W. Jones, C. D. Jaspers, I. Diaz-Sanchez, D. TI Anaerobic Bacteria Dominate The Airway Microbiome Of Patients With Acute Lung Injury Following Burn And Inhalation Injury SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 13-18, 2016 CL San Francisco, CA SP Amer Thorac Soc C1 [Walsh, D. M.; Yourstone, S.; Jones, S. W.; Jones, C. D.; Jaspers, I.] Univ North Carolina Chapel Hill, Chapel Hill, NC USA. [McCullough, S. D.; Kahle, J. J.; Diaz-Sanchez, D.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. EM dana_walsh@med.unc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2016 VL 193 MA A2105 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG0VE UT WOS:000390749601245 ER PT J AU Wang, L Hu, G AF Wang, Li Hu, Guang TI Remodeling super-enhancers and oncogenic transcription SO CELL CYCLE LA English DT Editorial Material DE chromatin remodeling; INO80; melanoma; oncogenic transcription; signal integration; super-enhancer ID MELANOMA C1 [Wang, Li] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China. [Wang, Li] Peking Union Med Coll, Beijing, Peoples R China. [Hu, Guang] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA. RP Wang, L (reprint author), Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China.; Wang, L (reprint author), Peking Union Med Coll, Beijing, Peoples R China.; Hu, G (reprint author), Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA. EM wangl@pumc.edu.cn; hug4@niehs.nih.gov NR 6 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1538-4101 EI 1551-4005 J9 CELL CYCLE JI Cell Cycle PY 2016 VL 15 IS 23 BP 3157 EP 3158 DI 10.1080/15384101.2016.1220715 PG 2 WC Cell Biology SC Cell Biology GA EF9RG UT WOS:000390666700006 PM 27579716 ER PT J AU Bradham, KD Green, W Hayes, H Nelson, C Alava, P Misenheimer, J Diamond, GL Thayer, WC Thomas, DJ AF Bradham, Karen D. Green, William Hayes, Hunter Nelson, Clay Alava, Pradeep Misenheimer, John Diamond, Gary L. Thayer, William C. Thomas, David J. TI Estimating relative bioavailability of soil lead in the mouse SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID CONTAMINATED SOILS; RATS; BIOACCESSIBILITY; SWINE AB Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb. C1 [Bradham, Karen D.; Nelson, Clay] US EPA, Publ Hlth Chem Branch, Exposure Methods & Measurements Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27709 USA. [Green, William; Hayes, Hunter; Thomas, David J.] US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA. [Alava, Pradeep] Natl Res Associateship Programs, Res Triangle Pk, NC USA. [Misenheimer, John] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Diamond, Gary L.; Thayer, William C.] SRC Inc, North Syracuse, NY USA. RP Bradham, KD (reprint author), US EPA, Publ Hlth Chem Branch, Exposure Methods & Measurements Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27709 USA. EM bradham.karen@epa.gov NR 17 TC 0 Z9 0 U1 6 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2016 VL 79 IS 24 BP 1179 EP 1182 DI 10.1080/15287394.2016.1221789 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EF8PQ UT WOS:000390591700002 PM 27767405 ER PT S AU Sahnow, DJ Penton, S Ake, T DeRosa, G Ely, J Lockwood, S Oliveira, C Plesha, R Proffitt, C Roman-Duval, J Sonnentrucker, P Taylor, J White, J AF Sahnow, David J. Penton, Steven Ake, Thomas DeRosa, Gisella Ely, Justin Lockwood, Sean Oliveira, Cristina Plesha, Rachel Proffitt, Charles Roman-Duval, Julia Sonnentrucker, Paule Taylor, Joanna White, James BE DenHerder, JWA Takahashi, T Bautz, M TI Correcting for errors due to walk and geometric distortion in the COS FUV detector SO SPACE TELESCOPES AND INSTRUMENTATION 2016: ULTRAVIOLET TO GAMMA RAY SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Space Telescopes and Instrumentation - Ultraviolet to Gamma Ray CY JUN 26-JUL 01, 2016 CL Edinburgh, SCOTLAND SP SPIE DE Cosmic Origins Spectrograph; Hubble Space Telescope; microchannel plates; detectors; ultraviolet; delay; line; COS; HST AB The Far Ultraviolet detector of the Cosmic Origin Spectrograph (COS) on the Hubble Space Telescope (HST) is subject to distortions on a range of spatial scales in its two-dimensional format due to its analog nature. Incomplete correction of these effects can lead to errors in wavelength scales and flux measurements in the calibrated spectra. Two of the largest sources of error are geometric distortion and walk. Although they are accounted for separately in the CalCOS calibration pipeline, they are highly coupled and can be considered as manifestations of the same effect. The current calibration pipeline does not apply any walk correction in the dispersion direction even though walk-induced errors can be more than a resolution element in some cases. The current geometric correction, which was derived without considering walk effects, is also known to have inaccuracies. As part of our efforts to improve the wavelength calibration of COS, we have revisited the existing walk and geometric correction using both prelaunch and on-orbit data. C1 [Sahnow, David J.; Penton, Steven; Ake, Thomas; DeRosa, Gisella; Ely, Justin; Lockwood, Sean; Oliveira, Cristina; Plesha, Rachel; Proffitt, Charles; Roman-Duval, Julia; Sonnentrucker, Paule; Taylor, Joanna; White, James] Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA. [Sonnentrucker, Paule] US EPA, Washington, DC 20460 USA. RP Sahnow, DJ (reprint author), Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA. EM sahnow@stsci.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-5106-0189-5; 978-1-5106-0190-1 J9 PROC SPIE PY 2016 VL 9905 AR UNSP 99052T DI 10.1117/12.2233091 PN 1 PG 6 WC Instruments & Instrumentation; Optics SC Instruments & Instrumentation; Optics GA BG2WP UT WOS:000387731500080 ER PT J AU Eiffert, S Noibi, Y Vesper, S Downs, J Fulk, F Wallace, J Pearson, M Winquist, A AF Eiffert, Samantha Noibi, Yomi Vesper, Stephen Downs, Jonathan Fulk, Florence Wallace, Juanita Pearson, Melanie Winquist, Andrea TI A Citizen-Science Study Documents Environmental Exposures and Asthma Prevalence in Two Communities SO JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH LA English DT Article ID INDEX; MOLD AB A citizen-science study was conducted in two low-income, flood-prone communities in Atlanta, Georgia, in order to document environmental exposures and the prevalence of occupant asthma. Teams consisting of a public-health graduate student and a resident from one of the two communities administered a questionnaire, inspected residences for mold growth, and collected a dust sample for quantifying mold contamination. The dust samples were analyzed for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI). Most residents (76%) were renters. The median duration of residence was 2.5 years. Although only 12% of occupants reported a history of flooding, 46% reported at least one water leak. Homes with visible mold (35%) had significantly (P < 0.05) higher mean ERMI values compared to homes without (14.0 versus 9.6). The prevalence of self-reported, current asthma among participants was 14%. In logistic regression models controlling for indoor smoking, among participants residing at their current residence for two years or less, a positive association was observed between asthma and the homes' ERMI values (adjusted odds ratio per unit increase in ERMI = 1.12, 95% confidence intervals (CI): 1.01-1.25; two-tailed P = 0.04). Documentation of the exposures and asthma prevalence has been presented to the communities and public officials. Community-based organizations have taken responsibility for planning and implementing activities in response to the study findings. C1 [Eiffert, Samantha; Downs, Jonathan; Pearson, Melanie; Winquist, Andrea] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. [Noibi, Yomi; Wallace, Juanita] ECO Act, 250 Georgia Ave,SE 309, Atlanta, GA 30312 USA. [Vesper, Stephen; Fulk, Florence] US EPA, Natl Exposure Res Lab, 26 West ML King Dr, Cincinnati, OH 45268 USA. RP Winquist, A (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM awinqui@emory.edu NR 19 TC 0 Z9 0 U1 0 U2 0 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 315 MADISON AVE 3RD FLR, STE 3070, NEW YORK, NY 10017 USA SN 1687-9805 EI 1687-9813 J9 J ENVIRON PUBLIC HEA JI J. Environ. Public Health PY 2016 AR 1962901 DI 10.1155/2016/1962901 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EE1RP UT WOS:000389360600001 ER PT J AU Mansouri, K Grulke, CM Richard, AM Judson, RS Williams, AJ AF Mansouri, K. Grulke, C. M. Richard, A. M. Judson, R. S. Williams, A. J. TI An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article; Proceedings Paper CT 17th International Conference on QSAR in Environmental and Health Sciences (QSAR) CY JUN 13-17, 2016 CL Miami Beach, FL DE data curation; standardization; QSAR modelling; physicochemical properties; Open Data ID MULTICRITERIA DECISION-MAKING; PARTITION-COEFFICIENTS; APPLICABILITY DOMAIN; OUTLIER DETECTION; PLS-REGRESSION; VALIDATION; PREDICTION; SELECTION; RANKING; CHEMINFORMATICS AB The increasing availability of large collections of chemical structures and associated experimental data provides an opportunity to build robust QSAR models for applications in different fields. One common concern is the quality of both the chemical structure information and associated experimental data. Here we describe the development of an automated KNIME workflow to curate and correct errors in the structure and identity of chemicals using the publicly available PHYSPROP physicochemical properties and environmental fate datasets. The workflow first assembles structure-identity pairs using up to four provided chemical identifiers, including chemical name, CASRNs, SMILES, and MolBlock. Problems detected included errors and mismatches in chemical structure formats, identifiers and various structure validation issues, including hypervalency and stereochemistry descriptions. Subsequently, a machine learning procedure was applied to evaluate the impact of this curation process. The performance of QSAR models built on only the highest-quality subset of the original dataset was compared with the larger curated and corrected dataset. The latter showed statistically improved predictive performance. The final workflow was used to curate the full list of PHYSPROP datasets, and is being made publicly available for further usage and integration by the scientific community. C1 [Mansouri, K.] Oak Ridge Inst Sci & Educ ORISE, Oak Ridge, TN 37830 USA. [Mansouri, K.; Grulke, C. M.; Richard, A. M.; Judson, R. S.; Williams, A. J.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. RP Williams, AJ (reprint author), US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. EM williams.antony@epa.gov NR 47 TC 2 Z9 2 U1 2 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1062-936X EI 1029-046X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PY 2016 VL 27 IS 11 BP 911 EP 937 DI 10.1080/1062936X.2016.1253611 PN 2 PG 27 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA EE1PY UT WOS:000389355800003 PM 27885862 ER PT J AU Schreinemachers, DM Ghio, AJ AF Schreinemachers, Dina M. Ghio, Andrew J. TI Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease SO ENVIRONMENTAL HEALTH INSIGHTS LA English DT Article DE environmental pollution; iron; ferritin; transferrin receptor ID WHEAT-PRODUCING STATES; GESTATIONAL DIABETES-MELLITUS; INSULIN-RESISTANCE SYNDROME; ISCHEMIC-HEART-DISEASE; REGULATORY PROTEINS; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; SERUM FERRITIN; IN-VITRO; MITOCHONDRIAL DYSFUNCTION AB Chronic disease has increased in the past several decades, and environmental pollutants have been implicated. The magnitude and variety of diseases may indicate the malfunctioning of some basic mechanisms underlying human health. Environmental pollutants demonstrate a capability to complex iron through electronegative functional groups containing oxygen, nitrogen, or sulfur. Cellular exposure to the chemical or its metabolite may cause a loss of requisite functional iron from intracellular sites. The cell is compelled to acquire further iron critical to its survival by activation of iron-responsive proteins and increasing iron import. Iron homeostasis in the exposed cells is altered due to a new equilibrium being established between iron-requiring cells and the inappropriate chelator (the pollutant or its catabolite). Following exposure to environmental pollutants, the perturbation of functional iron homeostasis may be the mechanism leading to adverse biological effects. Understanding the mechanism may lead to intervention methods for this major public health concern. C1 [Schreinemachers, Dina M.; Ghio, Andrew J.] US EPA, Environm Publ Hlth Div, NHEERL, ORD, Durham, NC 27709 USA. RP Schreinemachers, DM; Ghio, AJ (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, ORD, Durham, NC 27709 USA. EM schreinemachers.dina@epa.gov; ghio.andy@epa.gov NR 136 TC 2 Z9 2 U1 0 U2 0 PU LIBERTAS ACAD PI AUCKLAND PA PO BOX 300-874, ALBANY 0752, AUCKLAND, 00000, NEW ZEALAND SN 1178-6302 J9 ENVIRON HEALTH INSIG JI Environ. Health Insights PY 2016 VL 10 BP 35 EP 43 DI 10.4137/EHI.S36225 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EC1BS UT WOS:000387839100002 PM 26966372 ER PT J AU Shen, LZQ Melnikov, F Roethle, J Gudibanda, A Judson, RS Zimmerman, JB Anastas, PT AF Shen, Longzhu Q. Melnikov, Fjodor Roethle, John Gudibanda, Aditya Judson, Richard S. Zimmerman, Julie B. Anastas, Paul T. TI Coupled molecular design diagrams to guide safer chemical design with reduced likelihood of perturbing the NRF2-ARE antioxidant pathway and inducing cytotoxicity SO GREEN CHEMISTRY LA English DT Article ID ACUTE AQUATIC TOXICITY; EPAS TOXCAST PROGRAM; OXIDATIVE STRESS; ENVIRONMENTAL CHEMICALS; REGULARIZATION PATHS; COORDINATE DESCENT; KEAP1-NRF2 PATHWAY; SIGNALING PATHWAY; DRUG-METABOLISM; CELL-LINES AB The NRF2-ARE antioxidant pathway is an important biological sensing and regulating system that responds to xenochemicals. NRF2 senses chemically-caused production of reactive oxygen species (ROS) and electrophilic interactions with chemical species. Upon NRF2 activation, the expression of a wide array of genes will be upregulated to counteract oxidative or electrophilic insults. However, when the external disruption exceeds the inherent resilience of the biological system, cellular damage can occur, eventually leading to cytotoxicity. Induced NRF2 activity in in vitro assays is therefore a signal that a man-made chemical may cause unwanted cellular activity. This was the motivation to derive a chemical design strategy to minimize the risk that new chemicals would perturb this pathway. We constructed a logistic regression model using design variables derived from density functional theory (DFT) calculations and physical properties. The model showed excellent predictive power to distinguish between NRF2-active and inactive chemicals based on the EPA ToxCast high throughput screen (HTS) assay data (tested in the concentration range of 10(-3)-10(2) mu M). External evaluation showed that the area under the curve (AUC) for the receiver operating characteristic (ROC) of the model is 0.81 and the precision is 0.90. Combining this model with a previously developed cytotoxicity model, we developed a probabilistic design diagram to guide chemical design with the twin goals of minimizing NRF2 antioxidant pathway activity and cytotoxicity. This work initiated a simultaneous design strategy against two toxicity pathways of interest in molecular design research. C1 [Shen, Longzhu Q.; Melnikov, Fjodor; Zimmerman, Julie B.; Anastas, Paul T.] Sch Forestry & Environm Studies, New Haven, CT 06511 USA. [Shen, Longzhu Q.; Melnikov, Fjodor; Anastas, Paul T.] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06511 USA. [Gudibanda, Aditya] Yale Univ, Dept Comp Sci, New Haven, CT 06511 USA. [Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Zimmerman, Julie B.] Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06511 USA. RP Anastas, PT (reprint author), Sch Forestry & Environm Studies, New Haven, CT 06511 USA.; Anastas, PT (reprint author), Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06511 USA. EM paul.anastas@yale.edu FU NSF Division of Chemistry; Environmental Protection Agency [1339637]; QAFCO FX This research is supported by the NSF Division of Chemistry and the Environmental Protection Agency under Grant No. 1339637. The authors would like to thank for the helpful discussions with Dr Cong Li, Dr Terrence Kavanagh, Dr Jakub Kostal, and Dr Philip Coish. The authors acknowledged the computational support provided by Dr William Jorgensen, Dr Julian Tirado-Rives and Yale high performance computing platform. PTA would like to recognize funding support from QAFCO. NR 81 TC 0 Z9 0 U1 2 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 23 BP 6387 EP 6394 DI 10.1039/c6gc02073a PG 8 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA ED9YS UT WOS:000389230300025 ER PT J AU Noyes, PD Garcia, GR Tanguay, RL AF Noyes, Pamela D. Garcia, Gloria R. Tanguay, Robert L. TI Zebrafish as an in vivo model for sustainable chemical design SO GREEN CHEMISTRY LA English DT Review ID ENDOCRINE-DISRUPTING CHEMICALS; PERSISTENT ORGANIC POLLUTANTS; POLYCYCLIC AROMATIC-HYDROCARBONS; DANIO-RERIO EMBRYOS; ORGANOPHOSPHATE FLAME RETARDANTS; ASSOCIATIVE LEARNING-PERFORMANCE; EGFP TRANSGENIC ZEBRAFISH; XENOESTROGEN BISPHENOL-A; ADULT ZEBRAFISH; GREEN CHEMISTRY AB Heightened public awareness about the many thousands of chemicals in use and present as persistent contaminants in the environment has increased the demand for safer chemicals and more rigorous toxicity testing. There is a growing recognition that the use of traditional test models and empirical approaches is impractical for screening for toxicity the many thousands of chemicals in the environment and the hundreds of new chemistries introduced each year. These realities coupled with the green chemistry movement have prompted efforts to implement more predictive-based approaches to evaluate chemical toxicity early in product development. While used for many years in environmental toxicology and biomedicine, zebrafish use has accelerated more recently in genetic toxicology, high throughput screening (HTS), and behavioral testing. This review describes major advances in these testing methods that have positioned the zebrafish as a highly applicable model in chemical safety evaluations and sustainable chemistry efforts. Many toxic responses have been shown to be shared among fish and mammals owing to their generally well-conserved development, cellular networks, and organ systems. These shared responses have been observed for chemicals that impair endocrine functioning, development, and reproduction, as well as those that elicit cardiotoxicity and carcinogenicity, among other diseases. HTS technologies with zebrafish enable screening large chemical libraries for bioactivity that provide opportunities for testing early in product development. A compelling attribute of the zebrafish centers on being able to characterize toxicity mechanisms across multiple levels of biological organization from the genome to receptor interactions and cellular processes leading to phenotypic changes such as developmental malformations. Finally, there is a growing recognition of the links between human and wildlife health and the need for approaches that allow for assessment of real world multi-chemical exposures. The zebrafish is poised to be an important model in bridging these two conventionally separate areas of toxicology and characterizing the biological effects of chemical mixtures that could augment its role in sustainable chemistry. C1 [Noyes, Pamela D.; Garcia, Gloria R.; Tanguay, Robert L.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA. [Noyes, Pamela D.] US EPA, OSCP, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. RP Tanguay, RL (reprint author), Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA. EM robert.tanguay@oregonstate.edu FU EPA STAR grant [R835796]; NIH grant [P42 ES016465] FX The authors would like to thank Paroma Chatterjee, Anna Chlebowski, and John T. Gamble for generously providing image files of transgenic zebrafish. We also thank Dr Patience Browne, U.S. EPA, Jane Robbins, U.S. EPA, and Dr David Dix, U.S. EPA for their review and helpful feedback. Partially supported by EPA STAR grant # R835796 and NIH grant # P42 ES016465. NR 255 TC 0 Z9 0 U1 4 U2 4 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 24 BP 6410 EP 6430 DI 10.1039/c6gc02061e PG 21 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EE1LA UT WOS:000389341800001 ER PT J AU Alves, VM Capuzzi, SJ Muratov, EN Braga, RC Thornton, TE Fourches, D Strickland, J Kleinstreuer, N Andrade, CH Tropsha, A AF Alves, Vinicius M. Capuzzi, Stephen J. Muratov, Eugene N. Braga, Rodolpho C. Thornton, Thomas E. Fourches, Denis Strickland, Judy Kleinstreuer, Nicole Andrade, Carolina H. Tropsha, Alexander TI QSAR models of human data can enrich or replace LLNA testing for human skin sensitization SO GREEN CHEMISTRY LA English DT Article ID LYMPH-NODE ASSAY; DIVERSE ORGANIC-CHEMICALS; ALLERGIC CONTACT-DERMATITIS; INSULT PATCH TEST; RISK-ASSESSMENT; HAZARD IDENTIFICATION; GREEN CHEMISTRY; APPLICABILITY DOMAIN; CHEMOGENOMICS DATA; MAXIMIZATION TEST AB Skin sensitization is a major environmental and occupational health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. We have compiled, curated, analyzed, and compared the available human and LLNA data. Using these data, we have developed reliable computational models and applied them for the virtual screening of chemical libraries to identify putative skin sensitizers. The overall concordance between murine LLNA and human skin sensitization responses for a set of 135 unique chemicals was low (R = 28-43%), although several chemical classes had high concordance. We have succeeded to develop predictive QSAR models of all available human data with the external correct classification rate of 71%. A consensus model integrating concordant QSAR predictions and LLNA results afforded a higher CCR of 82% but at the expense of the reduced external dataset coverage (52%). We used the developed QSAR models for the virtual screening of the CosIng database and identified 1061 putative skin sensitizers; for seventeen of these compounds, we found published evidence of their skin sensitization effects. Models reported herein provide more accurate alternatives to LLNA testing for human skin sensitization assessment across diverse chemical data. In addition, they can also be used to guide the structural optimization of toxic compounds to reduce their skin sensitization potential. C1 [Alves, Vinicius M.; Capuzzi, Stephen J.; Muratov, Eugene N.; Thornton, Thomas E.; Tropsha, Alexander] Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Lab Mol Modeling, Chapel Hill, NC 27599 USA. [Alves, Vinicius M.; Braga, Rodolpho C.; Andrade, Carolina H.] Univ Fed Goias, Lab Mol Modeling & Design, Fac Pharm, BR-74605170 Goiania, Go, Brazil. [Muratov, Eugene N.] Odessa Natl Polytech Univ, Dept Chem Technol, UA-65000 Odessa, Ukraine. [Fourches, Denis] North Carolina State Univ, Bioinformat Res Ctr, Dept Chem, Raleigh, NC 27695 USA. [Strickland, Judy] Integrated Lab Syst Inc, POB 13501, Res Triangle Pk, NC 27709 USA. [Kleinstreuer, Nicole] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. [Tropsha, Alexander] Kazan Fed Univ, AM Butlerov Inst Chem, 18 Kremlyovskaya Str, Kazan 420008, Russia. RP Tropsha, A (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Lab Mol Modeling, Chapel Hill, NC 27599 USA.; Tropsha, A (reprint author), Kazan Fed Univ, AM Butlerov Inst Chem, 18 Kremlyovskaya Str, Kazan 420008, Russia. EM alex_tropsha@unc.edu FU NIH [GM096967]; FAPEG [201310267001095]; CNPq [400760/2014-2]; Russian Scientific Foundation [14-43-00024]; Russian Government Program for Competitive Growth of the Kazan Federal University; NIEHS, NIH [HHSN273201500010C] FX This study was supported in part by NIH (GM096967), FAPEG (grant 201310267001095), CNPq (grant 400760/2014-2), Russian Scientific Foundation (Agreement No. 14-43-00024 from October 1, 2014) and Russian Government Program for Competitive Growth of the Kazan Federal University. J. S. is supported by the NIEHS, NIH under Contract No. HHSN273201500010C to ILS in support of NICEATM. ILS staff provide technical support for NICEATM, but do not represent NIEHS, NTP, or the official positions of any federal agency. This article may be the work product of an employee or a group of employees of the NIEHS, NIH, or other organizations; however, the statements, opinions, or conclusions contained therein do not necessarily represent the statements, opinions, or conclusions of NIEHS, NIH, the United States government, or other organizations. The use of commercial product names is for comparative purposes only and does not constitute endorsement by any of the authors, organizations, or agencies. The authors express sincere gratitude to Drs Vladimir Poroikov, Dmitri Filimonov, and Alexey Zakharov for providing the GUSAR software. NR 115 TC 1 Z9 1 U1 1 U2 1 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 24 BP 6501 EP 6515 DI 10.1039/c6gc01836j PG 15 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EE1LA UT WOS:000389341800011 ER PT J AU Wallace, MAG Kormos, TM Pleil, JD AF Wallace, M. Ariel Geer Kormos, Tzipporah M. Pleil, Joachim D. TI Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID C-REACTIVE PROTEIN; AIR-POLLUTION EXPOSURE; MINIMALLY INVASIVE METHOD; HUMAN PLASMA PROTEOME; MASS-SPECTROMETRY; DNA-DAMAGE; IN-VITRO; GENETIC POLYMORPHISMS; PARTICULATE MATTER; HEMOGLOBIN ADDUCTS AB Environmental health science aims to link environmental pollution sources to adverse health outcomes to develop effective exposure intervention strategies that reduce long-term disease risks. Over the past few decades, the public health community recognized that health risk is driven by interaction between the human genome and external environment. Now that the human genetic code has been sequenced, establishing this G x E (gene-environment) interaction requires a similar effort to decode the human exposome, which is the accumulation of an individual's environmental exposures and metabolic responses throughout the person's lifetime. The exposome is composed of endogenous and exogenous chemicals, many of which are measurable as biomarkers in blood, breath, and urine. Exposure to pollutants is assessed by analyzing biofluids for the pollutant itself or its metabolic products. New methods are being developed to use a subset of biomarkers, termed bioindicators, to demonstrate biological changes indicative of future adverse health effects. Typically, environmental biomarkers are assessed using noninvasive (excreted) media, such as breath and urine. Blood is often avoided for biomonitoring due to practical reasons such as medical personnel, infectious waste, or clinical setting, despite the fact that blood represents the central compartment that interacts with every living cell and is the most relevant biofluid for certain applications and analyses. The aims of this study were to (1) review the current use of blood samples in environmental health research, (2) briefly contrast blood with other biological media, and (3) propose additional applications for blood analysis in human exposure research. C1 [Wallace, M. Ariel Geer; Pleil, Joachim D.] US EPA, Exposure Methods & Measurement Div, Natl Exposure Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Kormos, Tzipporah M.] Bayer CropSci AG, Res Triangle Pk, NC USA. RP Pleil, JD (reprint author), US EPA, Exposure Methods & Measurement Div, Natl Exposure Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM pleil.joachim@epa.gov NR 246 TC 0 Z9 0 U1 4 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PY 2016 VL 19 IS 8 BP 380 EP 409 DI 10.1080/10937404.2016.1215772 PG 30 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA ED2RB UT WOS:000388694800003 PM 27759495 ER PT J AU Razzaghmanesh, M Beecham, S Myers, B AF Razzaghmanesh, Mostafa Beecham, Simon Myers, Baden BE Pathak, CS Reinhart, D TI Long-Term Effects of Green Roofs on Stormwater Quality from Two Sites in Australia SO Water, Wastewater, and Stormwater and Urban Watershed Symposium LA English DT Proceedings Paper CT 16th Annual World Environmental and Water Resources Congress CY MAY 22-26, 2016 CL Amer Soc Civil Engineers, West Palm Beach, FL SP Amer Soc Civil Engineers, Environm & Water Resources Inst HO Amer Soc Civil Engineers DE Green roof; Stormwater quality; Receiving water AB This study aimed to predict the long term effects of outflow runoff quality from green roofs located at two sites in Adelaide, Australia. Samples of stormwater runoff were collected from Site 1, fertilized, and Site 2, unfertilised intensive and extensive green roofs. The non-parametric Mann Kendall trend analysis was employed in this study. The results for Site 1 showed decreasing trends for EC, turbidity, chloride, and TDS and an increasing trend for pH. There were no trends observed for nitrate and orthophosphate concentrations. The corresponding results for Site 2 showed increasing trends for nitrate+nitrite concentration from beds containing scoria and a sharply increasing trend from beds containing an organic-based media. For the crushed brick media type there was a slight decreasing trend for orthophosphate while total cations did not show any trend. This study demonstrated that the growing media is more likely to be the cause of the observed trends in drainage water. C1 [Razzaghmanesh, Mostafa] US EPA, ORD, Edison, NJ 08837 USA. [Beecham, Simon] Univ South Australia, Informat Technol Engn & Environm, Adelaide, SA, Australia. [Razzaghmanesh, Mostafa; Myers, Baden] Univ South Australia, Ctr Water Management & Reuse, Adelaide, SA, Australia. RP Razzaghmanesh, M (reprint author), US EPA, ORD, Edison, NJ 08837 USA.; Razzaghmanesh, M (reprint author), Univ South Australia, Ctr Water Management & Reuse, Adelaide, SA, Australia. EM Razzaghmanesh.Mostafa@ea.gov; Simon.Beecham@unisa.edu.au; Baden.Myers@unisa.edu.au NR 11 TC 0 Z9 0 U1 3 U2 3 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7988-9 PY 2016 BP 371 EP 379 PG 9 WC Engineering, Environmental; Water Resources SC Engineering; Water Resources GA BG4XD UT WOS:000389233500039 ER PT J AU Akers, DB Cunningham, JA MacCarthy, MF Annis, J Mihelcic, JR AF Akers, D. B. Cunningham, J. A. MacCarthy, M. F. Annis, J. Mihelcic, J. R. BE Pathak, CS Reinhart, D TI Lead (Pb) Contamination of Self-Supply Groundwater Systems in Coastal Madagascar: Estimates of Blood Lead Levels (BLLs) in Children SO World Environmental and Water Resources Congress 2016: Environmental, Sustainability, Groundwater, Hydraulic Fracturing, and Water Distribution Systems Analysis LA English DT Proceedings Paper CT 16th Annual World Environmental and Water Resources Congress CY MAY 22-26, 2016 CL Amer Soc Civil Engineers, West Palm Beach, FL SP Amer Soc Civil Engineers, Environm & Water Resources Inst HO Amer Soc Civil Engineers ID GROWTH AB Households in coastal Madagascar rely on locally manufactured pitcher-pump systems to provide water for drinking, cooking, and household use. These pumps typically include components made from lead (Pb). In a field study of 18 household pitcher pumps in the city of Tamatave, concentrations of Pb were frequently observed to exceed the World Health Organization (WHO) provisional guideline of 10 mu g/L. Under first-draw conditions (after a pump had been inactive for 1 h), 67% of samples were in excess of 10 mu g/L Pb, with a median concentration of 13 mu g/L. Flushing the pump systems before collecting water resulted in a statistically significant (p < 0.0001) decrease in Pb concentrations: 35% of samples collected after flushing exceeded 10 mu g/L, with a median concentration of 9 mu g/L. We modeled the ingestion of Pb with the Integrated Exposure Uptake Biokinetic model (IEUBK) to predict blood lead levels (BLLs) in children, thereby characterizing potential health risks. We modified the IEUBK model to account for the use of contaminated water in preparation of the top three foods in the Malagasy diet (rice, corn, cassava). Results indicate that this route may contribute up to 60% of overall Pb uptake in children, and therefore we conclude that the IEUBK model should be modified when applied to a developing-world context. The modified IEUBK predicts that as high as 94% of children could experience elevated BLLs (> 5 mu g/dL) in households or communities where the Pb concentration is at the high end of our field observations. C1 [Akers, D. B.] Univ S Florida, Dept Civil & Environm Engn, 4202 East Fowler Ave, Tampa, FL 33620 USA. [Akers, D. B.] US Environm Protect Agcy, Air Pesticides & Toxics Management Div, Region 4,61 Forsyth St SW, Atlanta, GA 30303 USA. [Cunningham, J. A.; Mihelcic, J. R.] Univ S Florida, Dept Civil & Environm Engn, 4202 East Fowler Ave,ENB 118, Tampa, FL 33620 USA. [MacCarthy, M. F.] Mercer Univ, Dept Environm Engn, 1501 Mercer Univ Dr, Macon, GA 31207 USA. [Annis, J.] CARE Int, USAID WASHplus program, Washington, DC 20009 USA. [Annis, J.] Tetra Tech, 1320 North Courthouse Rd,Suite 600, Arlington, VA 22201 USA. RP Akers, DB (reprint author), Univ S Florida, Dept Civil & Environm Engn, 4202 East Fowler Ave, Tampa, FL 33620 USA.; Akers, DB (reprint author), US Environm Protect Agcy, Air Pesticides & Toxics Management Div, Region 4,61 Forsyth St SW, Atlanta, GA 30303 USA. EM akers@mail.usf.edu; cunning@usf.edu; maccarthy_m@mercer.edu; Jonathan.Annis@tetratech.com; jm41@usf.edu NR 21 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7986-5 PY 2016 BP 299 EP 308 PG 10 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG5EH UT WOS:000389439700032 ER PT J AU Theunissen, PT Beken, S Beyer, BK Breslin, WJ Cappon, GD Chen, CL Chmielewski, G De Schaepdrijver, L Enright, B Foreman, JE Harrouk, W Hew, KW Hoberman, AM Hui, JY Knudsen, TB Laffan, SB Makris, SL Martin, M McNerney, ME Siezen, CL Stanislaus, DJ Stewart, J Thompson, KE Tornesi, B Van der Laan, JW Weinbauer, GF Wood, S Piersma, AH AF Theunissen, Peter T. Beken, Sonja Beyer, Bruce K. Breslin, William J. Cappon, Gregg D. Chen, Connie L. Chmielewski, Gary De Schaepdrijver, Luc Enright, Brian Foreman, Jennifer E. Harrouk, Wafa Hew, Kok-Wah Hoberman, Alan M. Hui, Julia Y. Knudsen, Thomas B. Laffan, Susan B. Makris, Susan L. Martin, Matt McNerney, Mary Ellen Siezen, Christine L. Stanislaus, Dinesh J. Stewart, Jane Thompson, Kary E. Tornesi, Belen Van der Laan, Jan Willem Weinbauer, Gerhard F. Wood, Sandra Piersma, Aldert H. TI Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE Pharmaceutical testing; embryo-fetal developmental toxicity; cross-species evaluation; non-clinical ID IN-VITRO; THALIDOMIDE; ABNORMALITIES; ANIMALS AB Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT testing could be limited to one species, or whether the testing in a second species could be decided on a case-by-case basis. As part of a consortium initiative, we built and queried a database of 379 compounds with EFDT studies (in both rat and rabbit animal models) conducted for marketed and non-marketed pharmaceuticals for their potential for adverse developmental and maternal outcomes, including EFDT incidence and the nature and severity of adverse findings. Manifestation of EFDT in either one or both species was demonstrated for 282 compounds (74%). EFDT was detected in only one species (rat or rabbit) in almost a third (31%, 118 compounds), with 58% (68 compounds) of rat studies and 42% (50 compounds) of rabbit studies identifying an EFDT signal. For 24 compounds (6%), fetal malformations were observed in one species (rat or rabbit) in the absence of any EFDT in the second species. In general, growth retardation, fetal variations, and malformations were more prominent in the rat, whereas embryo-fetal death was observed more often in the rabbit. Discordance across species may be attributed to factors such as maternal toxicity, study design differences, pharmacokinetic differences, and pharmacologic relevance of species. The current analysis suggests that in general both species are equally sensitive on the basis of an overall EFDT LOAEL comparison, but selective EFDT toxicity in one species is not uncommon. Also, there appear to be species differences in the prevalence of various EFDT manifestations (i.e. embryo-fetal death, growth retardation, and dysmorphogenesis) between rat and rabbit, suggesting that the use of both species has a higher probability of detecting developmental toxicants than either one alone. C1 [Theunissen, Peter T.; Van der Laan, Jan Willem; Piersma, Aldert H.] Natl Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands. [Theunissen, Peter T.; Siezen, Christine L.; Van der Laan, Jan Willem] Med Evaluat Board, Graadt van Roggenweg 500, NL-3531 AH Utrecht, Netherlands. [Theunissen, Peter T.] Univ Appl Sci Utrecht HU, Innovat Testing Life Sci & Chem, Utrecht, Netherlands. [Beken, Sonja] Fed Agcy Med & Hlth Prod, Brussels, Belgium. [Beyer, Bruce K.] Sanofi US Inc, Bridgewater, NJ USA. [Breslin, William J.] Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN USA. [Cappon, Gregg D.] Pfizer Worldwide Res & Dev, Groton, CT USA. [Chen, Connie L.] ILSI Hlth & Environm Sci Inst, Washington, DC USA. [Chmielewski, Gary] Covance Labs Inc, Greenfield, IN USA. [De Schaepdrijver, Luc] Janssen R&D, Preclin Dev & Safety Beerse, Beerse, Belgium. [Enright, Brian; Tornesi, Belen] AbbVie Inc, N Chicago, IL USA. [Foreman, Jennifer E.] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Harrouk, Wafa] US FDA, Silver Spring, MD USA. [Hew, Kok-Wah] Takeda Pharmaceut Co, Deerfield, IL USA. [Hoberman, Alan M.] Charles River Labs, Preclin Serv, Horsham, PA USA. [Hui, Julia Y.] Celgene Corp, Summit, NJ USA. [Knudsen, Thomas B.; Martin, Matt] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Laffan, Susan B.; Stanislaus, Dinesh J.] GlaxoSmithKline, Safety Assessment, King Of Prussia, PA USA. [Makris, Susan L.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [McNerney, Mary Ellen; Thompson, Kary E.] Bristol Myers Squibb, Drug Safety Evaluat, New Brunswick, NJ USA. [Stewart, Jane] AstraZeneca, Drug Safety & Metab, Macclesfield, Cheshire, England. [Weinbauer, Gerhard F.] Covance Preclin Serv GmbH, Munster, Germany. [Wood, Sandra] Merck Res Labs, Upper Gwynedd, PA USA. [Piersma, Aldert H.] Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Sci, Utrecht, Netherlands. RP Theunissen, PT (reprint author), Med Evaluat Board, Graadt van Roggenweg 500, NL-3531 AH Utrecht, Netherlands. EM P.Theunissen@cbg-meb.nl FU SLIM project; Dutch Government, Dept. Econimical Affairs; Utrecht Province; Utrecht City Administration [PID101063] FX SLIM project, by the Dutch Government, Dept. Econimical Affairs; The Utrecht Province and The Utrecht City Administration [PID101063]. ILSI HESI, 10.13039/100008663 NR 22 TC 0 Z9 0 U1 5 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1040-8444 EI 1547-6898 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PY 2016 VL 46 IS 10 BP 900 EP 910 DI 10.1080/10408444.2016.1224807 PG 11 WC Toxicology SC Toxicology GA ED3CF UT WOS:000388726200004 PM 27848393 ER PT S AU Antoniou, MG Zhao, C O'Shea, KE Zhang, GS Dionysiou, DD Zhao, C Han, C Nadagouda, MN Choi, H Fotiou, T Triantis, TM Hiskia, A AF Antoniou, Maria G. Zhao, Cen O'Shea, Kevin E. Zhang, Geshan Dionysiou, Dionysios D. Zhao, Chun Han, Changseok Nadagouda, Mallikarjuna N. Choi, Hyeok Fotiou, Theodora Triantis, Theodoros M. Hiskia, Anastasia BE Dionysiou, DD Puma, GL Ye, J Schneider, J Bahnemann, D TI Photocatalytic Degradation of Organic Contaminants in Water: Process Optimization and Degradation Pathways SO PHOTOCATALYSIS: APPLICATIONS SE RSC Energy and Environment Series LA English DT Article; Book Chapter ID TITANIUM-DIOXIDE PHOTOCATALYSTS; ADVANCED OXIDATION PROCESSES; TIO2 AQUEOUS SUSPENSIONS; NITROGEN-DOPED TIO2; MICROCYSTIN-LR; HETEROGENEOUS PHOTOCATALYSIS; BY-PRODUCTS; CYANOTOXIN CYLINDROSPERMOPSIN; ANTIBIOTIC OXYTETRACYCLINE; ENVIRONMENTAL APPLICATIONS C1 [Antoniou, Maria G.] Cyprus Univ Technol, Dept Environm Sci & Technol, CY-3036 Lemesos, Cyprus. [Zhao, Cen; O'Shea, Kevin E.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [Zhang, Geshan; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn DBCEE, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [Zhang, Geshan] Zhejiang Univ Technol, Dept Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China. [Zhao, Chun] Chongqing Univ, Minist Educ, Key Lab Three Gorges Reservoir Reg Ecoenvironm, Chongqing 400045, Peoples R China. [Han, Changseok] US EPA, Clean Proc Branch, Sustainable Technol Div, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Water Qual Management Branch, Cincinnati, OH 45268 USA. [Choi, Hyeok] Univ Texas Arlington, Dept Civil Engn, 416 Yates St, Arlington, TX 76019 USA. [Fotiou, Theodora; Triantis, Theodoros M.; Hiskia, Anastasia] NCSR Demokritos, Inst Nanosci & Nanotechnol, Catalyt Photocatalyt Proc & Environm Anal Lab, Neapoleos 25, Athens 15341, Greece. RP Antoniou, MG (reprint author), Cyprus Univ Technol, Dept Environm Sci & Technol, CY-3036 Lemesos, Cyprus. EM maria.antoniou@cut.ac.cy OI TRIANTIS, THEODOROS/0000-0002-7899-176X NR 104 TC 1 Z9 1 U1 1 U2 1 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND SN 2044-0774 BN 978-1-78262-710-4; 978-1-78262-709-8 J9 RSC ENERGY ENVIRON S PY 2016 IS 15 BP 1 EP 34 PG 34 WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical SC Chemistry; Energy & Fuels; Engineering GA BG3XA UT WOS:000388330100002 ER PT J AU Kenyon, EM Eklund, C Lipscomb, JC Pegram, RA AF Kenyon, Elaina M. Eklund, Christopher Lipscomb, John C. Pegram, Rex A. TI The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM) SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE In vitro to in vivo extrapolation (IVIVE); scaling factors; variation; PBPK model ID HUMAN MICROSOMAL PROTEIN; HUMAN LIVER; PHARMACOKINETIC MODELS; ASSESSING EXPOSURE; METABOLISM; WATER; TRIHALOMETHANES; VARIANCE; SENSITIVITY; CLEARANCE AB A rate for hepatic metabolism (V-max) determined in vitro must be scaled for in vivo use in a physiologically based pharmacokinetic (PBPK) model. This requires the use of scaling factors such as mg of microsomal protein per gram of liver (MPPGL) and liver mass (FVL). Variation in MPPGL and FVL impacts variation in Vmax, and hence PBPK model-derived estimates of internal dose used in dose response analysis. The impacts of adult human variation in MPPGL and FVL on estimates of internal dose were assessed using a human PBPK model for bromodichloromethane (BDCM), a water disinfection byproduct, for multiple internal dose metrics for two exposure scenarios (single 0.25 liter drink of water or 10 min shower) under plausible (5 mu g/L) and high level (20 mu g/L) water concentrations. For both concentrations, all internal dose metrics were changed less than 5% for the showering scenario (combined inhalation and dermal exposure). In contrast, a 27-fold variation in area under the curve (AUC) for BDCM in venous blood was observed at both oral exposure concentrations, whereas total amount of BDCM metabolized in liver was relatively unchanged. This analysis demonstrates that variability in the scaling factors used for in vitro to in vivo extrapolation (IVIVE) for metabolic rate parameters can have a significant route-dependent impact on estimates of internal dose under environmentally relevant exposure scenarios. This indicates the need to evaluate both uncertainty and variability for scaling factors used for IVIVE. C1 [Kenyon, Elaina M.; Eklund, Christopher; Pegram, Rex A.] US EPA, Integrated Syst Toxicol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Lipscomb, John C.] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Cincinnati, OH 45268 USA. RP Kenyon, EM (reprint author), US EPA, NHEERL ISTD, PB Mail Drop B105-03, Res Triangle Pk, NC 27711 USA. EM kenyon.elaina@epa.gov NR 31 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2016 VL 26 IS 8 BP 620 EP 626 DI 10.1080/15376516.2016.1225141 PG 7 WC Toxicology SC Toxicology GA ED6KE UT WOS:000388963700007 PM 27595344 ER PT J AU Cook, PM Swintek, J Dawson, TD Chapman, D Etterson, MA Hoff, D AF Cook, Philip M. Swintek, Joseph Dawson, Timothy D. Chapman, David Etterson, Mathew A. Hoff, Dale TI Quantitative structure-mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID FIBER DISSOLUTION RATE; ASBESTOS FIBERS; MALIGNANT MESOTHELIOMA; PARIETAL PLEURA; MINERAL FIBERS; EXPOSURE; ERIONITE; BIOPERSISTENCE; PULMONARY; AMPHIBOLE AB Cancer potencies of mineral and synthetic elongated particle mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. An extensive rat intrapleural dose characterization data set with a wide variety of elongated particles physicochemical properties facilitated statistical analyses of pleural mesothelioma response data combined from several studies for evaluation of alternative dose-response models. Utilizing logistic regression of individual elongated particle dimensional variations within each test sample, four major findings emerged: (1) Mild acid leaching provides superior prediction of tumor incidence compared to samples that were not leached; (2) sum of the elongated particle surface areas from mildly acid-leached samples provides the optimum holistic dose-response model; (3) progressive removal of dose associated with very short and/or thin elongated particles significantly degrades the resultant particle count and surface area dose-based predictive model fits; and (4) alternative biologically plausible model adjustments provide evidence for reduced potency of elongated particles with aspect ratios less than 8 and lengths greater than 80 mu m. Regardless of these adjustments, the optimum predictive models strongly incorporate potency attributable to abundant short elongated particles in proportion to their surface area. Transmission electron microscopy analyses of low-temperature-ashed pleural membrane and lung tissues 5.5 mo post intrapleural exposures do not support hypotheses that short elongated particles that reach the pleural space are rapidly eliminated. Low-aspect-ratio elongated particles were still abundant in pleural membrane tissues but may have reduced potencies due to aggregation tendencies and therefore lower potential for intracellular presence. C1 [Cook, Philip M.; Etterson, Mathew A.; Hoff, Dale] US EPA, ORD, NHEERL, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Swintek, Joseph; Dawson, Timothy D.] Badger Tech Serv BTS, Duluth, MN USA. [Chapman, David] Wilson Environm Labs, Duluth, MN USA. RP Hoff, D (reprint author), US EPA, ORD, NHEERL, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM hoff.dale@epa.gov NR 61 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PY 2016 VL 19 IS 5-6 BP 266 EP 288 DI 10.1080/10937404.2016.1195326 PG 23 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EC0JX UT WOS:000387788000009 PM 27705548 ER PT B AU Shah, SR Morse, SA Calfee, MW Ryan, SP AF Shah, Sanjiv R. Morse, Stephen A. Calfee, Michael W. Ryan, Shawn P. BE Salem, H Katz, SA TI Bacillus anthracis: An Aerobiological Threat SO AEROBIOLOGY: THE TOXICOLOGY OF AIRBORNE PATHOGENS AND TOXINS SE Issues in Toxicology LA English DT Article; Book Chapter ID QUANTITATIVE 3-STEP METHOD; HUMID AIR DECONTAMINATION; AEROSOL CHALLENGE MODEL; LUNG EPITHELIAL-CELLS; AL HAKAM SPORES; INHALATIONAL ANTHRAX; CEREUS-GROUP; UNITED-STATES; CUTANEOUS ANTHRAX; PROTECTIVE ANTIGEN C1 [Shah, Sanjiv R.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA. [Morse, Stephen A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Calfee, Michael W.; Ryan, Shawn P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. RP Shah, SR (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA. EM shah.sanjiv@epa.gov NR 268 TC 0 Z9 0 U1 2 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND BN 978-1-84973-791-3; 978-1-84973-594-0 J9 ISSUES TOXICOL PY 2016 VL 25 BP 248 EP 299 D2 10.1039/9781849737913 PG 52 WC Infectious Diseases; Microbiology; Toxicology SC Infectious Diseases; Microbiology; Toxicology GA BG3NS UT WOS:000388089900008 ER PT S AU Mansouri, K Judson, RS AF Mansouri, Kamel Judson, Richard S. BE Benfenati, E TI In Silico Study of In Vitro GPCR Assays by QSAR Modeling SO IN SILICO METHODS FOR PREDICTING DRUG TOXICITY SE Methods in Molecular Biology LA English DT Article; Book Chapter DE QSAR; GPCR; ToxCast; Toxicity; Machine learning ID LEAST-SQUARES REGRESSION; EPAS TOXCAST PROGRAM; ENVIRONMENTAL CHEMICALS; PLS-REGRESSION; TOXICITY; TOXICOLOGY; RECEPTOR AB The US EPA's ToxCast program is screening thousands of chemicals of environmental interest in hundreds of in vitro high-throughput screening (HTS) assays. One goal is to prioritize chemicals for more detailed analyses based on activity in assays that target molecular initiating events (MIEs) of adverse outcome pathways (AOPs). However, the chemical space of interest for environmental exposure is much wider than ToxCast's chemical library. In silico methods such as quantitative structure-activity relationships (QSARs) are proven and cost--effective approaches to predict biological activity for untested chemicals. However, empirical data is needed to build and validate QSARs. ToxCast has developed datasets for about 2000 chemicals ideal for training and testing QSAR models. The overall goal of the present work was to develop QSAR models to fill the data gaps in larger environmental chemical lists. The specific aim of the current work was to build QSAR models for 18 G-protein-coupled receptor (GPCR) assays, part of the aminergic family. Two QSAR modeling strategies were adopted: classification models were developed to separate chemicals into active/ non-active classes, and then regression models were built to predict the potency values of the bioassays for the active chemicals. Multiple software programs were used to calculate constitutional, topological, and substructural molecular descriptors from two-dimensional (2D) chemical structures. Model-fitting methods included PLSDA (partial least square discriminant analysis), SVMs (support vector machines), kNNs (k-nearest neighbors), and PLSs (partial least squares). Genetic algorithms (GAs) were applied as a variable selection technique to select the most predictive molecular descriptors for each assay. N-fold cross-validation (CV) coupled with multi-criteria decision-making fitting criteria was used to evaluate the models. Finally, the models were applied to make predictions within the established chemical space limits. The most accurate model was for the bovine nonselective dopamine receptor (bDR_ NS) GPCR assay, for which the classification balanced accuracy reached 0.96 in fitting and 0.95 in fivefold CV, with only two latent variables. These results demonstrate the accuracy of QSAR models to predict the biological activity of chemicals specifically for each one of the studied assays. C1 [Mansouri, Kamel] US EPA, ORISE, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Mansouri, K (reprint author), US EPA, ORISE, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. OI Mansouri, Kamel/0000-0002-6426-8036 NR 51 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1064-3745 BN 978-1-4939-3609-0; 978-1-4939-3607-6 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2016 VL 1425 BP 361 EP 381 DI 10.1007/978-1-4939-3609-0_16 D2 10.1007/978-1-4939-3609-0 PG 21 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA BG2YT UT WOS:000387782000017 PM 27311474 ER PT S AU Kostich, M Lange, R AF Kostich, Mitchell Laenge, Reinhard BE Hester, RE Harrison, RM TI Ecotoxicology, Environmental Risk Assessment and Potential Impact on Human Healthy SO PHARMACEUTICALS IN THE ENVIRONMENT SE Issues in Environmental Science and Technology Series LA English DT Article; Book Chapter ID ANTIBIOTIC-RESISTANCE GENES; MUNICIPAL WASTE-WATER; MALE FATHEAD MINNOWS; FISH BLOOD-PLASMA; HUMAN PHARMACEUTICALS; AQUATIC ENVIRONMENT; DRINKING-WATER; SURFACE WATERS; PIMEPHALES-PROMELAS; EXPOSURE ASSESSMENT AB This chapter examines potential risks posed by active pharmaceutical ingredients (APIs) present in the aquatic environment to humans and aquatic life. We begin by describing the mechanisms by which pharmaceuticals enter the vertebrate body, produce effects and leave the body. Then we describe theoretical and practical issues limiting the certainty which can be expected from risk estimates. This is followed by a description of particular considerations applicable to evaluation of human risks, along with a summary of methods and conclusions from some important studies examining those risks. A similar discussion of theoretical issues and selected data relevant for estimating risks to aquatic life is then presented. We finish by discussing potential contributions of antibiotics present in the environment to the development and spread of antibiotic resistance. We conclude that there are too few data to definitively address every concern, particularly risks to aquatic life and contributions to development of antibiotic resistance. On the other hand, available data suggest risks to humans are very low for all active pharmaceutical ingredients (APIs) and risks to aquatic life are very low for most APIs. Although aquatic risks cannot be as confidently ruled out for a few APIs, potential risks are probably limited to particularly contaminated regions in close vicinity to concentrated pollution sources, such as wastewater treatment plant outfalls. C1 [Kostich, Mitchell] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, AWBERC, MD 592,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Laenge, Reinhard] Bayer HealthCare, Global Drug Discovery Global Early Dev, Mullerstr 178,S116,05,553, D-13342 Berlin, Germany. RP Kostich, M (reprint author), US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, AWBERC, MD 592,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM kostich.mitchell@epa.gov; reinhard.laenge@bayer.com NR 105 TC 0 Z9 0 U1 3 U2 3 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND SN 1350-7583 BN 978-1-78262-234-5; 978-1-78262-189-8 J9 ISS ENVIRON SCI TECH JI Iss Environ. Sci. Technol. Ser. PY 2016 IS 41 BP 180 EP 215 PG 36 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA BG3OM UT WOS:000388098600007 ER PT J AU Planchart, A Mattingly, CJ Allen, D Ceger, P Casey, W Hinton, D Kanungo, J Kullman, SW Tal, T Bondesson, M Burgess, SM Sullivan, C Kim, C Behl, M Padilla, S Reif, DM Tanguay, RL Hamm, J AF Planchart, Antonio Mattingly, Carolyn J. Allen, David Ceger, Patricia Casey, Warren Hinton, David Kanungo, Jyotshna Kullman, Seth W. Tal, Tamara Bondesson, Maria Burgess, Shawn M. Sullivan, Con Kim, Carol Behl, Mamta Padilla, Stephanie Reif, David M. Tanguay, Robert L. Hamm, Jon TI Advancing Toxicology Research Using In Vivo High Throughput Toxicology with Small Fish Models SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION LA English DT Article DE aquatic models; 21st century toxicology; alternatives ID ZEBRAFISH DANIO-RERIO; TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOCRINE-DISRUPTING CHEMICALS; MATERNAL STILBESTROL THERAPY; ARYL-HYDROCARBON RECEPTOR; INNATE IMMUNE-RESPONSE; ZINC-FINGER NUCLEASES; CYPRINUS-CARPIO L.; ENVIRONMENTAL CHEMICALS; TRANSGENIC ZEBRAFISH AB Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent models, including low maintenance and husbandry costs, high fecundity, genetic diversity, physiology similar to that of traditional biomedical models, and reduced animal welfare concerns. The Collaborative Workshop on Aquatic Models and 21st Century Toxicology was held at North Carolina State University on May 5-6, 2014, in Raleigh, North Carolina, USA. Participants discussed the ways in which small fish are being used as models to screen toxicants and understand mechanisms of toxicity. Workshop participants agreed that the lack of standardized protocols is an impediment to broader acceptance of these models, whereas development of standardized protocols, validation, and subsequent regulatory acceptance would facilitate greater usage. Given the advantages and increasing application of small fish models, there was widespread interest in follow-up workshops to review and discuss developments in their use. In this article, we summarize the recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies, as well as many of the advances in the field of toxicology that resulted from using small fish species, including advances in developmental toxicology, cardiovascular toxicology, neurotoxicology, and immunotoxicology. We also review many emerging issues that will benefit from using small fish species, especially zebrafish, and new technologies that will enable using these organisms to yield results unprecedented in their information content to better understand how toxicants affect development and health. C1 [Planchart, Antonio; Mattingly, Carolyn J.; Kullman, Seth W.; Reif, David M.] North Carolina State Univ, Dept Biol Sci, Campus Box 7633, Raleigh, NC 27695 USA. [Planchart, Antonio; Mattingly, Carolyn J.; Kullman, Seth W.; Reif, David M.] North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC USA. [Allen, David; Ceger, Patricia; Hamm, Jon] Integrated Lab Syst Inc, Res Triangle Pk, NC USA. [Casey, Warren] NIEHS, Natl Toxicol Program, Interagency Ctr Evaluat Alternat Toxicol Methods, POB 12233, Res Triangle Pk, NC 27709 USA. [Hinton, David] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Kanungo, Jyotshna] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. [Tal, Tamara; Padilla, Stephanie] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Bondesson, Maria] Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX USA. [Burgess, Shawn M.] NHGRI, Bethesda, MD 20892 USA. [Sullivan, Con; Kim, Carol] Univ Maine, Dept Mol & Biomed Sci, Orono, ME USA. [Sullivan, Con; Kim, Carol] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME USA. [Behl, Mamta] NIEHS, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA. [Tanguay, Robert L.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA. RP Planchart, A (reprint author), North Carolina State Univ, Dept Biol Sci, Campus Box 7633, Raleigh, NC 27695 USA. EM ajplanch@ncsu.edu FU North Carolina State University Center for Human Health and the Environment (NIH/NIEHS) [P30ES025128] FX The authors would like to thank Ms. Catherine Sprankle of Integrated Laboratory Systems, Inc., for editorial assistance. Financial support for the workshop was provided by the North Carolina State University Center for Human Health and the Environment (NIH/NIEHS P30ES025128). NR 202 TC 1 Z9 1 U1 8 U2 8 PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH PI HEILDEBERG PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY SN 1868-596X EI 1868-8551 J9 ALTEX-ALTERN ANIM EX JI ALTEX-Altern. Anim. Exp. PY 2016 VL 33 IS 4 BP 435 EP 452 DI 10.14573/altex.1601281 PG 18 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EB5RY UT WOS:000387439200007 PM 27328013 ER PT J AU Thoma, ED Brantley, HL Oliver, KD Whitaker, DA Mukerjee, S Mitchell, B Wu, T Squier, B Escobar, E Cousett, TA Gross-Davis, CA Schmidt, H Sosna, D Weiss, H AF Thoma, Eben D. Brantley, Halley L. Oliver, Karen D. Whitaker, Donald A. Mukerjee, Shaibal Mitchell, Bill Wu, Tai Squier, Bill Escobar, Elsy Cousett, Tamira A. Gross-Davis, Carol Ann Schmidt, Howard Sosna, Dennis Weiss, Hallie TI South Philadelphia passive sampler and sensor study SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID METHANE EMISSIONS; PADS; OIL; AIR AB From June 2013 to March 2015, in total 41 passive sampler deployments of 2 wk duration each were conducted at 17 sites in South Philadelphia, PA, with results for benzene discussed here. Complementary time-resolved measurements with lower cost prototype fenceline sensors and an open-path ultraviolet differential optical absorption spectrometer were also conducted. Minimum passive sampler benzene concentrations for each sampling period ranged from 0.08 ppbv to 0.65 ppbv, with a mean of 0.25 ppbv, and were negatively correlated with ambient temperature (-0.01 ppbv/degrees C, R-2 = 0.68). Co-deployed duplicate passive sampler pairs (N = 609) demonstrated good precision with an average and maximum percent difference of 1.5% and 34%, respectively. A group of passive samplers located within 50 m of a refinery fenceline had a study mean benzene concentration of 1.22 ppbv, whereas a group of samplers located in communities >1 km distant from facilities had a mean of 0.29 ppbv. The difference in the means of these groups was statistically significant at the 95% confidence level (p < 0.001). A decreasing gradient in benzene concentrations moving away from the facilities was observed, as was a significant period-to-period variation. The highest recorded 2-wk average benzene concentration for the fenceline group was 3.11 ppbv. During this period, time-resolved data from the prototype sensors and the open-path spectrometer detected a benzene signal from the west on one day in particular, with the highest 5-min path-averaged benzene concentration measured at 24 ppbv. Implications: Using a variation of EPA's passive sampler refinery fenceline monitoring method, coupled with time-resolved measurements, a multiyear study in South Philadelphia informed benzene concentrations near facilities and in communities. The combination of measurement strategies can assist facilities in identification and mitigation of emissions from fugitive sources and improve information on air quality complex air sheds. C1 [Thoma, Eben D.; Brantley, Halley L.; Whitaker, Donald A.; Mukerjee, Shaibal; Mitchell, Bill; Wu, Tai] US EPA, Off Res & Dev, Natl Risk Managment Res Lab, Durham, NC USA. [Brantley, Halley L.] Oak Ridge Inst Sci & Engn, Durham, NC USA. [Oliver, Karen D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Durham, NC USA. [Mitchell, Bill] US EPA, Off Enforcement & Compliance Assurance, Natl Environm Invest Ctr, Denver, CO USA. [Escobar, Elsy] Arcadis US Inc, Philadelphia, PA USA. [Cousett, Tamira A.] Jacobs Technol Inc, Durham, NC USA. [Gross-Davis, Carol Ann; Schmidt, Howard] US EPA, Reg 3, Philadelphia, PA USA. [Sosna, Dennis; Weiss, Hallie] City Philadelphia, Dept Publ Hlth, Air Management Serv Lab, Philadelphia, PA USA. RP Thoma, ED (reprint author), US EPA, Off Res & Dev, 109 TW Alexander Dr, Durham, NC 27711 USA. EM thoma.eben@epa.gov FU U.S. EPA ORD's Air, Climate, and Energy (ACE); Regional Applied Research Effort (RARE); EPA's Community-Scale Air Toxics Ambient Monitoring Grant Program [EPA-OAR-OAQPS-11-05, 96311601-1] FX The authors thank EPA colleagues Dave Nash, and Wan Jiao, now with ICF International, for development of the prototype fenceline sensors used in this study. This work would not have been possible without the efforts of EPA's Maribel Colon, John Turlington, and Lillian Alston (EPA SEE program) on PS laboratory and data analysis. We thank EPA colleagues Jason DeWees, Ray Merrill, Brenda Shine, Ken Garing, Edgar Thompson, Adam Eisele, and Ron Landy for ongoing collaboration on these topics. Thanks to Mark Modrak, now with AECOM, and Shahrooz Amin, now with Industrial Monitoring and Control Corporation, for their efforts on this project. Thanks to Tom Wisniewski, Scott McEwan, and Paul Johnson with Cerex Environmental Solutions for data analysis assistance. Funding for the PS and sensor portion of the study was provided by U.S. EPA ORD's Air, Climate, and Energy (ACE) and Regional Applied Research Effort (RARE) programs. The AMS open-path deployment was funded under EPA's Community-Scale Air Toxics Ambient Monitoring Grant Program (EPA-OAR-OAQPS-11-05; 96311601-1). The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Mention of any products or trade names does not constitute endorsement. NR 16 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PY 2016 VL 66 IS 10 BP 959 EP 970 DI 10.1080/10962247.2016.1184724 PG 12 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EA7XN UT WOS:000386846300003 PM 27192142 ER PT J AU Joo, SH Knecht, M Su, CM Seo, S Lawrence, R AF Joo, Sung Hee Knecht, Marc Su, Chunming Seo, Seokju Lawrence, Randy TI Influence of siloxane on the transport of ZnO nanoparticles from different release pathways in saturated sand SO RSC ADVANCES LA English DT Article ID NATURAL ORGANIC-MATTER; ZINC-OXIDE NANOPARTICLES; POROUS-MEDIA ROLE; TIO2 NANOPARTICLES; CIRCUMNEUTRAL PH; IONIC-STRENGTH; FLOW-RATE; WATER; SUSPENSIONS; ADSORPTION AB The production of nanomaterials (NMs) is expected to grow continuously, yet their transformation, transport, release mechanisms, and interactions with contaminants under environmental conditions remain poorly understood. Few studies have investigated the effects of contaminants on fate and transport of NMs, especially siloxanes that are widely found in products. It is hypothesized that the model contaminant, siloxane (e.g., 1,1,3,3-tetramethyldisiloxane (TMDS)) may influence the mechanisms and transport kinetics of NMs under different release pathways. Sand column experiments were carried out under two different scenarios: the release from a mixed TMDS and nano-ZnO suspension (A) and the release of nano-ZnO from sand contaminated with TMDS (B). Results show that interparticle reactions are dominant in (A) and particle-porous interactions are responsible for blocking effects governing in (B). Insights, especially the kinetics of nano-ZnO from co-transport by a contaminant and from porous media preloaded with a contaminant, and environmental factors affecting the release and retention of nano-ZnO in saturated sand are unveiled. These two dominant transport mechanisms (e.g., interparticle reactions and blocking effects) were derived. This study indicates that the release of ZnO NPs is influenced by the presence of TMDS; the extent of mobility and their transport pathways depend on the pre-existence of TMDS in porous media. C1 [Joo, Sung Hee; Seo, Seokju] Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. [Knecht, Marc; Lawrence, Randy] Univ Miami, Dept Chem, 1301 Mem Dr, Coral Gables, FL 33146 USA. [Su, Chunming] US EPA, Off Res & Dev, Natl Risk Management, Ground Water & Ecosyst Restorat Div,Res Lab, Ada, OK 74820 USA. RP Joo, SH (reprint author), Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. EM s.joo1@miami.edu FU Provost Research Award FX This work was supported by Provost Research Award given to SHJ at the University of Miami. This work does not reflect EPA's policy. NR 57 TC 0 Z9 0 U1 2 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2016 VL 6 IS 102 BP 100494 EP 100503 DI 10.1039/c6ra22820h PG 10 WC Chemistry, Multidisciplinary SC Chemistry GA EA2QP UT WOS:000386439800105 ER PT B AU Hughes, MF AF Hughes, Michael F. BE States, JC TI HISTORY OF ARSENIC AS A POISON AND A MEDICINAL AGENT SO ARSENIC: EXPOSURE SOURCES, HEALTH RISKS, AND MECHANISMS OF TOXICITY LA English DT Article; Book Chapter ID BLACKFOOT DISEASE; DRINKING-WATER; HEAVY-METALS; WEST-BENGAL; DOSE-RESPONSE; SKIN-CANCER; EXPOSURE; REALGAR; GROUNDWATER; TOXICITY C1 [Hughes, Michael F.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Hughes, MF (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. NR 80 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA BN 978-1-118-87659-6; 978-1-118-51114-5 PY 2016 BP 3 EP 22 PG 20 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BG0IF UT WOS:000386249000002 ER PT B AU Thomas, DJ AF Thomas, David J. BE States, JC TI THE CHEMISTRY AND METABOLISM OF ARSENIC SO ARSENIC: EXPOSURE SOURCES, HEALTH RISKS, AND MECHANISMS OF TOXICITY LA English DT Article; Book Chapter ID OXIDATION-STATE METHYLTRANSFERASE; MONOMETHYLARSONOUS ACID MMA(III); S-ADENOSYLMETHIONINE METHYLTRANSFERASE; VITRO TOXICOLOGICAL CHARACTERIZATION; ATOMIC ABSORPTION SPECTROMETRY; URINARY-BLADDER EPITHELIUM; PLASMA-MASS SPECTROMETRY; RAT-LIVER CYTOSOL; IC-ICP-MS; IN-VITRO C1 [Thomas, David J.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. RP Thomas, DJ (reprint author), US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. NR 155 TC 0 Z9 0 U1 4 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA BN 978-1-118-87659-6; 978-1-118-51114-5 PY 2016 BP 81 EP 109 PG 29 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BG0IF UT WOS:000386249000005 ER PT B AU Kenyon, EM Clewell, HJ AF Kenyon, Elaina M. Clewell, Harvey J., III BE States, JC TI TOXICOKINETICS AND PHARMACOKINETIC MODELING OF ARSENIC SO ARSENIC: EXPOSURE SOURCES, HEALTH RISKS, AND MECHANISMS OF TOXICITY LA English DT Article; Book Chapter ID RISK-ASSESSMENT; METHYLTRANSFERASE CYT19; METHYLATED METABOLITES; MATHEMATICAL-MODEL; URINARY-EXCRETION; PBPK MODEL; IN-VITRO; EXPOSURE; MICE; HEPATOCYTES C1 [Kenyon, Elaina M.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. [Clewell, Harvey J., III] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA. RP Kenyon, EM (reprint author), US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. NR 45 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA BN 978-1-118-87659-6; 978-1-118-51114-5 PY 2016 BP 495 EP 509 PG 15 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BG0IF UT WOS:000386249000023 ER PT J AU Colmenares, JC Varma, RS Lisowski, P AF Colmenares, Juan Carlos Varma, Rajender S. Lisowski, Pawel TI Sustainable hybrid photocatalysts: titania immobilized on carbon materials derived from renewable and biodegradable resources SO GREEN CHEMISTRY LA English DT Review ID COAL FLY-ASH; MAGNETIC ACTIVATED CARBON; ENVIRONMENTAL GREEN CHEMISTRY; VISIBLE-LIGHT IRRADIATION; TIO2 NANOPARTICLES; AQUEOUS-SOLUTION; BACTERIAL CELLULOSE; ENHANCED ACTIVITY; LIGNOCELLULOSIC BIOMASS; DIOXIDE PHOTOCATALYSTS AB This review comprises the preparation, properties and heterogeneous photocatalytic applications of TiO2 immobilized on carbon materials derived from earth-abundant, renewable and biodegradable agricultural residues and sea food waste resources. The overview provides key scientific insights into widely used TiO2 supported on carbonaceous materials emanating from biopolymeric materials such as lignin, cellulose, cellulose acetate, bacterial cellulose, bamboo, wood, starch, chitosan and agricultural residues (biochar, charcoal, activated carbon and their magnetic forms, coal fly ash) or seafood wastes namely eggshell, clamshell and fish scales; materials that serve as a support/template for TiO2. Heightened awareness and future inspirational developments for the valorisation of various forms of carbonaceous functional materials is the main objective. This appraisal abridges various strategies available to upgrade renewable carbon-based feedstock via the generation of sustainable TiO2/carbon functional materials and provides remarks on their future prospects. Hopefully, this will stimulate the development of efficient and novel composite photocatalysts and engender the necessary knowledge base for further advancements in greener photocatalytic technologies. C1 [Colmenares, Juan Carlos; Lisowski, Pawel] Polish Acad Sci, Inst Phys Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA. RP Colmenares, JC; Lisowski, P (reprint author), Polish Acad Sci, Inst Phys Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland. EM jcarloscolmenares@ichf.edu.pl; plisowski@ichf.edu.pl FU COST Action [FP1306]; National Science Centre (NCN) in Poland [2015/17/N/ST5/03330] FX Prof. Dr Juan C. Colmenares gratefully acknowledges support from COST Action FP1306 for networking and possibilities for meetings and future students exchange. Pawel Lisowski would like also to thank the National Science Centre (NCN) in Poland for the research project 2015/17/N/ST5/03330. NR 186 TC 1 Z9 1 U1 25 U2 25 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 21 BP 5736 EP 5750 DI 10.1039/c6gc02477g PG 15 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EA2LX UT WOS:000386425000004 ER PT J AU Calfee, MW Tufts, J Meyer, K McConkey, K Mickelsen, L Rose, L Dowell, C Delaney, L Weber, A Morse, S Chaitram, J Gray, M AF Calfee, M. Worth Tufts, Jenia Meyer, Kathryn McConkey, Katrina Mickelsen, Leroy Rose, Laura Dowell, Chad Delaney, Lisa Weber, Angela Morse, Stephen Chaitram, Jasmine Gray, Marshall TI Evaluation of standardized sample collection, packaging, and decontamination procedures to assess cross-contamination potential during Bacillus anthracis incident response operations SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE Bacillus anthracis; cross-contamination; decontamination; sampling ID INHALATIONAL ANTHRAX; NONPOROUS SURFACES; UNITED-STATES; SPORES; BIOTERRORISM; EFFICACY; FOMITES; EFFICIENCY; EXPOSURE; RECOVERY AB Sample collection procedures and primary receptacle (sample container and bag) decontamination methods should prevent contaminant transfer between contaminated and non-contaminated surfaces and areas during bio-incident operations. Cross-contamination of personnel, equipment, or sample containers may result in the exfiltration of biological agent from the exclusion (hot) zone and have unintended negative consequences on response resources, activities and outcomes. The current study was designed to: (1) evaluate currently recommended sample collection and packaging procedures to identify procedural steps that may increase the likelihood of spore exfiltration or contaminant transfer; (2) evaluate the efficacy of currently recommended primary receptacle decontamination procedures; and (3) evaluate the efficacy of outer packaging decontamination methods. Wet-and dry-deposited fluorescent tracer powder was used in contaminant transfer tests to qualitatively evaluate the currently-recommended sample collection procedures. Bacillus atrophaeus spores, a surrogate for Bacillus anthracis, were used to evaluate the efficacy of spray-and wipe-based decontamination procedures. Both decontamination procedures were quantitatively evaluated on three types of sample packaging materials (corrugated fiberboard, polystyrene foam, and polyethylene plastic), and two contamination mechanisms (wet or dry inoculums). Contaminant transfer results suggested that size-appropriate gloves should be worn by personnel, templates should not be taped to or removed from surfaces, and primary receptacles should be selected carefully. The decontamination tests indicated that wipe-based decontamination procedures may be more effective than spray-based procedures; efficacy was not influenced by material type but was affected by the inoculation method. Incomplete surface decontamination was observed in all tests with dry inoculums. This study provides a foundation for optimizing current B. anthracis response procedures to minimize contaminant exfiltration. C1 [Calfee, M. Worth; Gray, Marshall] US EPA, Natl Homeland Secur Res Ctr, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. [Tufts, Jenia; Meyer, Kathryn] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [McConkey, Katrina] Booz Allen Hamilton, Res Triangle Pk, NC USA. [Mickelsen, Leroy] US EPA, CBRN Consequence Management Advisory Div, Res Triangle Pk, NC 27711 USA. [Rose, Laura] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. [Dowell, Chad; Delaney, Lisa; Weber, Angela] NIOSH, Ctr Dis Control & Prevent, Emergency Preparedness & Response Off, Atlanta, GA USA. [Morse, Stephen] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne & Waterborne Dis, Atlanta, GA USA. [Chaitram, Jasmine] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Preparedness & Emerging Infect, Atlanta, GA USA. RP Calfee, MW (reprint author), US EPA, Natl Homeland Secur Res Ctr, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM Calfee.worth@epa.gov FU Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development FX This research was supported in part by an appointment to the Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 43 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2016 VL 13 IS 12 BP 980 EP 992 DI 10.1080/15459624.2016.1200725 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EA1ZE UT WOS:000386390000009 PM 27362274 ER PT J AU Ball, N Cronin, MTD Shen, J Blackburn, K Booth, ED Bouhifd, M Donley, E Egnash, L Hastings, C Juberg, DR Kleensang, A Kleinstreuer, N Kroese, ED Lee, AC Luechtefeld, T Maertens, A Marty, S Naciff, JM Palmer, J Pamies, D Penman, M Richarz, AN Russo, DP Stuard, SB Patlewicz, G van Ravenzwaay, B Wu, SD Zhu, H Hartung, T AF Ball, Nicholas Cronin, Mark T. D. Shen, Jie Blackburn, Karen Booth, Ewan D. Bouhifd, Mounir Donley, Elizabeth Egnash, Laura Hastings, Charles Juberg, Daland R. Kleensang, Andre Kleinstreuer, Nicole Kroese, E. Dinant Lee, Adam C. Luechtefeld, Thomas Maertens, Alexandra Marty, Sue Naciff, Jorge M. Palmer, Jessica Pamies, David Penman, Mike Richarz, Andrea-Nicole Russo, Daniel P. Stuard, Sharon B. Patlewicz, Grace van Ravenzwaay, Bennard Wu, Shengde Zhu, Hao Hartung, Thomas TI Toward Good Read-Across Practice (GRAP) Guidance SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION LA English DT Article DE computational toxicology; chemical similarity; read-across; hazard assessment; uncertainty ID DECISION-MAKING FRAMEWORKS; CHEMICAL SAFETY ASSESSMENT; RISK-ASSESSMENT; REPRODUCTIVE TOXICITY; CHEMISTRY DATABASES; HAZARD ASSESSMENT; CELL-CULTURE; NANOMATERIALS; TOXICOLOGY; FOOD AB Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key role in complying with legislation such as the European REACH regulation, the lack of consensus regarding the extent and type of evidence necessary to support it often hampers its successful application and acceptance by regulatory authorities. Despite a potentially broad user community, expertise is still concentrated across a handful of organizations and individuals. In order to facilitate the effective use of read-across, this document presents the state of the art, summarizes insights learned from reviewing ECHA published decisions regarding the relative successes/pitfalls surrounding read-across under REACH, and compiles the relevant activities and guidance documents. Special emphasis is given to the available existing tools and approaches, an analysis of ECHA's published final decisions associated with all levels of compliance checks and testing proposals, the consideration and expression of uncertainty, the use of biological support data, and the impact of the ECHA Read-Across Assessment Framework (RAAF) published in 2015. C1 [Ball, Nicholas; Juberg, Daland R.; Marty, Sue] Dow Chem Co USA, Midland, MI 48674 USA. [Ball, Nicholas; Juberg, Daland R.; Marty, Sue] Dow AgroSci, Indianapolis, IN USA. [Cronin, Mark T. D.; Richarz, Andrea-Nicole] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, Merseyside, England. [Shen, Jie] Res Inst Fragrance Mat Inc, Woodcliff Lake, NJ USA. [Blackburn, Karen; Naciff, Jorge M.; Stuard, Sharon B.; Wu, Shengde] Procter & Gamble Co, Cincinnati, OH USA. [Booth, Ewan D.] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell, Berks, England. [Bouhifd, Mounir; Kleensang, Andre; Luechtefeld, Thomas; Maertens, Alexandra; Pamies, David; Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, CAAT, Baltimore, MD USA. [Donley, Elizabeth; Egnash, Laura; Palmer, Jessica] Stemina Biomarker Discovery Inc, Madison, WI USA. [Hastings, Charles] BASF SE, Ludwigshafen, Germany. [Hastings, Charles] BASF SE, Res Triangle Pk, NC USA. [Kleinstreuer, Nicole] NIEHS, Natl Toxicol Program, Interagency Ctr Evaluat Alternat Toxicol Methods, POB 12233, Res Triangle Pk, NC 27709 USA. [Kroese, E. Dinant; van Ravenzwaay, Bennard] TNO, Risk Anal Prod Dev, Zeist, Netherlands. [Lee, Adam C.] DuPont Haskell Global Ctr Hlth, Newark, NJ USA. [Lee, Adam C.] DuPont Haskell Global Ctr Environm Sci, Newark, NJ USA. [Penman, Mike] Penman Consulting, Brussels, Belgium. [Russo, Daniel P.; Zhu, Hao] Rutgers State Univ, Dept Chem, Camden, NJ USA. [Russo, Daniel P.; Zhu, Hao] Rutgers State Univ, Ctr Computat & Integrat Biol, Camden, NJ USA. [Patlewicz, Grace] US EPA, ORD, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. [Hartung, Thomas] Univ Konstanz, CAAT Europe, Constance, Germany. RP Hartung, T (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, 615 North Wolfe St, Baltimore, MD 21205 USA. EM thartun1@jhu.edu OI Kleensang, Andre/0000-0002-4564-7399; Kleinstreuer, Nicole/0000-0002-7914-3682 FU NIEHS training grant [T32 ES007141]; EU Horizon 2020 project EUToxRisk FX The input and valuable discussion by Dr David Steup, Shell, as well as Moyinoluwa D. Adenuga and James J. Freeman, Exxon-Mobil Biomedical Sciences, is gratefully appreciated. T.L. was supported by NIEHS training grant (T32 ES007141). Support from the EU Horizon 2020 project EUToxRisk is gratefully appreciated. NR 76 TC 11 Z9 11 U1 6 U2 7 PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH PI HEILDEBERG PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY SN 1868-596X EI 1868-8551 J9 ALTEX-ALTERN ANIM EX JI ALTEX-Altern. Anim. Exp. PY 2016 VL 33 IS 2 BP 149 EP 166 DI 10.14573/altex.1601251 PG 18 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA DZ0FI UT WOS:000385512500007 PM 26863606 ER PT S AU Kursinski, ER Ward, D Otarola, AC McGhee, J Stovern, M Sammler, K Reed, H Erickson, D McCormick, C Griggs, E AF Kursinski, E. R. Ward, D. Otarola, A. C. McGhee, J. Stovern, M. Sammler, K. Reed, H. Erickson, D. McCormick, C. Griggs, E. BE Xiong, XJ Kuriakose, SA Kimura, T TI Atmospheric profiling via satellite to satellite occultations near water and ozone absorption lines for weather and climate SO EARTH OBSERVING MISSIONS AND SENSORS: DEVELOPMENT, IMPLEMENTATION, AND CHARACTERIZATION IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Earth Observing Missions and Sensors - Development, Implementation, and Characterization IV CY APR 04-07, 2016 CL Indian Soc Remote Sensing, New Delhi, INDIA SP SPIE, Indian Space Res Org, Minist Earth Sci, Natl Aeronaut & Space Adm HO Indian Soc Remote Sensing ID SENSITIVITY; TEMPERATURE; CIRCULATION; CLOUDS; SYSTEM AB Significantly reducing weather and climate prediction uncertainty requires global observations with substantially higher information content than present observations provide. While GPS occultations have provided a major advance, GPS observations of the atmosphere are limited by wavelengths chosen specifically to minimize interaction with the atmosphere. Significantly more information can be obtained via satellite to satellite occultations made at wavelengths chosen specifically to characterize the atmosphere. Here we describe such a system that will probe cm- and mm-wavelength water vapor absorption lines called the Active Temperature, Ozone and Moisture Microwave Spectrometer (ATOMMS). Profiling both the speed and absorption of light enables ATOMMS to profile temperature, pressure and humidity simultaneously, which GPS occultations cannot do, as well as profile clouds and turbulence. We summarize the ATOMMS concept and its theoretical performance. We describe field measurements made with a prototype ATOMMS instrument and several important capabilities demonstrated with those ground based measurements including retrieving temporal variations in path-averaged water vapor to 1%, in clear, cloudy and rainy conditions, up to optical depths of 17, remotely sensing turbulence and determining rain rates. We conclude with a vision of a future ATOMMS low Earth orbiting satellite constellation designed to take advantage of synergies between observational needs for weather and climate, ATOMMS unprecedented orbital remote sensing capabilities and recent cubesat technological innovations that enable a constellation of dozens of very small spacecraft to achieve many critical, but as yet unfulfilled, monitoring and forecasting needs. C1 [Kursinski, E. R.; McGhee, J.; McCormick, C.; Griggs, E.] Space Sci & Engn LLC, 2425 55th St,Ste A-150, Boulder, CO 80301 USA. [Ward, D.; Sammler, K.] Univ Arizona, 1118 4th St, Tucson, AZ 85721 USA. [Otarola, A. C.] TMT Int Observ, 100 W Walnut St,Ste 300, Pasadena, CA 91124 USA. [Stovern, M.] US EPA, Denver, CO 80202 USA. [Reed, H.; Erickson, D.] Univ Colorado, LASP, Boulder, CO 80303 USA. RP Kursinski, ER (reprint author), Space Sci & Engn LLC, 2425 55th St,Ste A-150, Boulder, CO 80301 USA. NR 31 TC 1 Z9 1 U1 3 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-5106-0122-2 J9 PROC SPIE PY 2016 VL 9881 AR UNSP 98810Z DI 10.1117/12.2224038 PG 20 WC Engineering, Electrical & Electronic; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Engineering; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BF9PH UT WOS:000385792900017 ER PT J AU Morzillo, AT Kreakie, BJ Netusil, NR Yeakley, JA Ozawa, CP Duncan, SL AF Morzillo, Anita T. Kreakie, Betty J. Netusil, Noelwah R. Yeakley, J. Alan Ozawa, Connie P. Duncan, Sally L. TI Resident perceptions of natural resources between cities and across scales in the Pacific Northwest SO ECOLOGY AND SOCIETY LA English DT Article DE human dimensions; landscape ecology; natural resources; Pacific Northwest; perceptions; urban ecosystems ID ENVIRONMENTAL VALUE ORIENTATIONS; RURAL-URBAN DIFFERENCES; STREET TREES; LAND-USE; PUBLIC TRANSPORTATION; METROPOLITAN-AREA; RODENT CONTROL; WATER-QUALITY; GREEN SPACES; ATTITUDES AB As the global population becomes increasingly urban, research is needed to explore how local culture, land use, and policy will influence urban natural resource management. We used a broad-scale comparative approach and survey of residents within the Portland (Oregon)-Vancouver (Washington) metropolitan areas, USA, two states with similar geographical and ecological characteristics, but different approaches to land-use planning, to explore resident perceptions about natural resources at three scales of analysis: property level ("at or near my house"), neighborhood ("within a 20-minute walk from my house"), and metro level ("across the metro area"). At the metro-level scale, nonmetric multidimensional scaling revealed that the two cities were quite similar. However, affinity for particular landscape characteristics existed within each city with the greatest difference generally at the property-level scale. Portland respondents expressed affinity for large mature trees, tree-lined streets, public transportation, and proximity to stores and services. Vancouver respondents expressed affinity for plentiful accessible parking. We suggest three explanations that likely are not mutually exclusive. First, respondents are segmented based on preferences for particular amenities, such as convenience versus commuter needs. Second, historical land-use and tax policy legacies may influence individual decisions. Third, more environmentally attuned worldviews may influence an individual's desire to produce environmentally friendly outcomes. Our findings highlight the importance of acknowledging variations in residents' affinities for landscape characteristics across different scales and locations because these differences may influence future land-use policies about urban natural resources. C1 [Morzillo, Anita T.] Univ Connecticut, Dept Nat Resources & Environm, Storrs, CT 06269 USA. [Kreakie, Betty J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Atlantic Ecol Div, Washington, DC USA. [Netusil, Noelwah R.] Reed Coll, Dept Econ, Portland, OR USA. [Yeakley, J. Alan] Univ Maryland Baltimore Cty, Dept Geog & Environm Syst, Baltimore, MD 21228 USA. [Ozawa, Connie P.] Portland State Univ, Toulan Sch Urban Studies & Planning, Portland, OR 97207 USA. [Duncan, Sally L.] Oregon State Univ, Sch Publ Policy, Corvallis, OR 97331 USA. RP Morzillo, AT (reprint author), Univ Connecticut, Dept Nat Resources & Environm, Storrs, CT 06269 USA. FU National Science Foundation [0948983, 0948826, 0949042]; Oregon State University General Research Fund; Portland State University; Reed College FX The Portland-Vancouver ULTRA-Ex efforts include many project personnel from Portland State University, Washington State University - Vancouver, Oregon State University, Reed College, and the US Forest Service Pacific Northwest Research Station, with input from several land management agencies. Thank you to the Portland-Vancouver ULTRA-Ex project team for inspiring this research based on a friendly project meeting quarrel about which of the two cities is better. We individually thank K. Heavener, H. Chang, V. Shandas, J. Kline, S. Bollens, G. Rollwagen-Bollens, P. Thiers, S. Gordon, M. Dresner, A. Phillip, B. Pratt, T. Gibson, M. Smith, J. Bevis, M. Atkinson, A. Mertig, D. Kloster, L. Keener-Eck, three anonymous reviewers, and all Portland-Vancouver residents who completed the survey. This work was supported by the National Science Foundation Grants #0948983, #0948826, and #0949042, Oregon State University General Research Fund, Portland State University, and Reed College. Use of human subjects was approved by Oregon State University (IRB #5022), Portland State University (#111816), Washington State University (#12019), Reed College (#Netusil 2012), and University of Connecticut (#H14-194). This paper has not been subjected to formal US EPA review. Therefore, it does not necessarily reflect the views of the Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use by the US Government. This is contribution number ORD-012384 of the Atlantic Ecology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory. NR 124 TC 0 Z9 0 U1 3 U2 3 PU RESILIENCE ALLIANCE PI WOLFVILLE PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA SN 1708-3087 J9 ECOL SOC JI Ecol. Soc. PY 2016 VL 21 IS 3 AR 14 DI 10.5751/ES-08478-210314 PG 14 WC Ecology; Environmental Studies SC Environmental Sciences & Ecology GA DZ3CB UT WOS:000385720400007 ER PT J AU Lowry, GV Hill, RJ Harper, S Rawle, AF Hendren, CO Klaessig, F Nobbmann, U Sayre, P Rumble, J AF Lowry, Gregory V. Hill, Reghan J. Harper, Stacey Rawle, Alan F. Hendren, Christine Ogilvie Klaessig, Fred Nobbmann, Ulf Sayre, Philip Rumble, John TI Guidance to improve the scientific value of zetapotential measurements in nanoEHS SO ENVIRONMENTAL SCIENCE-NANO LA English DT Review ID NATURAL ORGANIC-MATTER; ELECTROPHORETIC MOBILITY; PHYSICOCHEMICAL PROPERTIES; ELECTROKINETIC PHENOMENA; TITANIUM-DIOXIDE; IN-VITRO; NANOPARTICLES; PARTICLES; SUSPENSIONS; NANOMATERIALS AB Nanoparticle zeta-potentials are relatively easy to measure, and have consistently been proposed in guidance documents as a particle property that must be included for complete nanoparticle characterization. There is also an increasing interest in integrating data collected on nanomaterial properties and behavior measured in different systems (e.g. in vitro assays, surface water, soil) to identify the properties controlling nanomaterial fate and effects, to be able to integrate and reuse datasets beyond their original intent, and ultimately to predict behaviors of new nanomaterials based on their measured properties (i.e. read across), including zeta-potential. Several confounding factors pose difficulty in taking, integrating and interpreting this measurement consistently. Zeta-potential is a modeled quantity determined from measurements of the electrophoretic mobility in a suspension, and its value depends on the nanomaterial properties, the solution conditions, and the theoretical model applied. The ability to use zeta-potential as an explanatory variable for measured behaviors in different systems (or potentially to predict specific behaviors) therefore requires robust reporting with relevant meta-data for the measurement conditions and the model used to convert mobility measurements to zeta-potentials. However, there is currently no such standardization for reporting in the nanoEHS literature. The objective of this tutorial review is to familiarize the nanoEHS research community with the zeta-potential concept and the factors that influence its calculated value and interpretation, including the effects of adsorbed macromolecules. We also provide practical guidance on the precision of measurement, interpretation of zeta-potential as an explanatory variable for processes of interest (e.g. toxicity, environmental fate), and provide advice for addressing common challenges associated with making meaningful zeta-potential measurements using commercial instruments. Finally, we provide specific guidance on the parameters that need to be reported with zetapotential measurements to maximize interpretability and to support scientific synthesis across data sets. C1 [Lowry, Gregory V.] Carnegie Mellon Univ, Civil & Environm Engn, Pittsburgh, PA 15213 USA. [Lowry, Gregory V.; Hendren, Christine Ogilvie] Ctr Environm Implicat Nanotechnol, El Paso, TX 79968 USA. [Hill, Reghan J.] McGill Univ, Dept Chem Engn, Montreal, PQ H3A 0C5, Canada. [Harper, Stacey] Oregon State Univ, Environm & Mol Toxicol, Chem Biol & Environm Engn, Corvallis, OR 97331 USA. [Rawle, Alan F.; Nobbmann, Ulf] Malvern Instruments Inc, Westborough, MA 01581 USA. [Hendren, Christine Ogilvie] Duke Univ, Civil & Environm Engn, Durham, NC 27708 USA. [Klaessig, Fred] Penn Bio Nano Syst LLC, Doylestown, PA 18901 USA. [Sayre, Philip] US EPA, Washington, DC 20460 USA. [Rumble, John] R&R Data Serv, Gaithersburg, MD 20877 USA. RP Lowry, GV (reprint author), Carnegie Mellon Univ, Civil & Environm Engn, Pittsburgh, PA 15213 USA.; Lowry, GV (reprint author), Ctr Environm Implicat Nanotechnol, El Paso, TX 79968 USA.; Hill, RJ (reprint author), McGill Univ, Dept Chem Engn, Montreal, PQ H3A 0C5, Canada. EM glowry@cmu.edu; reghan.hill@mcgill.ca FU National Science Foundation Center for Hierarchical Manufacturing [CMMI-1025020]; National Science Foundation [CBET-1548199] FX The authors thank the National Science Foundation Center for Hierarchical Manufacturing (CMMI-1025020) for their support of the zeta-potential workshop, and the National Science Foundation (CBET-1548199) supporting the 4th Annual Sustainable Nanotechnology Organization Meeting where the workshop was held. NR 46 TC 3 Z9 3 U1 12 U2 12 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON SCI-NANO JI Environ.-Sci. Nano PY 2016 VL 3 IS 5 BP 953 EP 965 DI 10.1039/c6en00136j PG 13 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA DY6SI UT WOS:000385257900003 ER PT J AU Razzaghmanesh, M Beecham, S Salemi, T AF Razzaghmanesh, Mostafa Beecham, Simon Salemi, Telma TI The role of green roofs in mitigating Urban Heat Island effects in the metropolitan area of Adelaide, South Australia SO URBAN FORESTRY & URBAN GREENING LA English DT Article DE Green roofs; Urban heat island; Climate change adaptation ID EXTENSIVE LIVING ROOF; DRY CLIMATE; VEGETATION; QUALITY; ENVIRONMENTS; TEMPERATURES; PERFORMANCE; SURVIVAL; BENEFITS; COMFORT AB Changing an urban environment and replacing vegetated surfaces with low albedo materials is one of the reasons for increasing temperatures in an urban environment and consequently also one of the key causes of urban heat island effects. In this study, an experimental investigation at the micro-scale and also a numerical simulation at the macro-scale of a typical urban environment in Adelaide were conducted to estimate the potential for mitigating the UHI effect. The results showed that existing low albedo materials such as asphalt, metal roofs and brick pavements contribute to the heat island potential. Also, urban development and a lack of natural vegetation contribute to increased temperatures in cities. The ability of two types of extensive and intensive green roofs to reduce the surrounding micro-climate temperature were monitored. The results showed that they have significant cooling effects in summer time and could behave as an insulation layer to keep buildings warmer in the winter. Furthermore, different scenarios of adding green roofs to the Adelaide urban environment were investigated using the Envi-MET model. The scenario modelling of adding green roofs in a typical urban area in Adelaide, Australia, supported the hypothesis that this can lead to reductions in energy consumption in the Adelaide urban environment. Also an increased use of other water sensitive urban design technologies such as green walls and street trees together with the adoption of high albedo materials is recommended for achieving the optimum efficiency in terms of reducing urban temperatures and mitigating urban heat island effects. (C) 2015 Elsevier GmbH. All rights reserved. C1 [Razzaghmanesh, Mostafa; Beecham, Simon] Univ South Australia, Sch Nat & Built Environm, Ctr Water Management & Reuse, Adelaide, SA, Australia. [Salemi, Telma] Flinders Univ S Australia, Sch Environm, Adelaide, SA, Australia. RP Razzaghmanesh, M (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Edison, NJ 08837 USA. EM mostafa.razzaghmanesh@mymail.unisa.edu.au RI Beecham, Simon/M-1544-2016 OI Razzaghmanesh, Mostafa/0000-0002-0583-1482; Beecham, Simon/0000-0002-9884-3852 NR 45 TC 7 Z9 8 U1 20 U2 21 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1618-8667 J9 URBAN FOR URBAN GREE JI Urban For. Urban Green. PY 2016 VL 15 BP 89 EP 102 DI 10.1016/j.ufug.2015.11.013 PG 14 WC Plant Sciences; Environmental Studies; Forestry; Urban Studies SC Plant Sciences; Environmental Sciences & Ecology; Forestry; Urban Studies GA DY2HF UT WOS:000384913000014 ER PT J AU Michael, LC Brown, GG Melnyk, LJ AF Michael, Larry C. Brown, G. Gordon Melnyk, Lisa Jo TI Estimation of pyrethroid pesticide intake using regression modeling of food groups based on composite dietary samples SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES LA English DT Article DE Community duplicate diet; dietary pesticide intake; regression modeling; sample compositing; pyrethroids ID CHILDREN AB Population-based estimates of pesticide intake are needed to characterize exposure for particular demographic groups based on their dietary behaviors. Regression modeling performed on measurements of selected pesticides in composited duplicate diet samples allowed (1) estimation of pesticide intakes for a defined demographic community, and (2) comparison of dietary pesticide intakes between the composite and individual samples. Extant databases were useful for assigning individual samples to composites, but they could not provide the breadth of information needed to facilitate measurable levels in every composite. Composite sample measurements were found to be good predictors of pyrethroid pesticide levels in their individual sample constituents where sufficient measurements are available above the method detection limit. Statistical inference shows little evidence of differences between individual and composite measurements and suggests that regression modeling of food groups based on composite dietary samples may provide an effective tool for estimating dietary pesticide intake for a defined population. C1 [Michael, Larry C.] RTI Int, Res Triangle Pk, NC USA. [Brown, G. Gordon] SAS Inst Inc, Cary, NC USA. [Melnyk, Lisa Jo] US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Melnyk, LJ (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM melnyk.lisa@epa.gov FU US Environmental Protection Agency through its Office of Research and Development [EP-C-05-060] FX The US Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under Contract EP-C-05-060 to RTI International. It has been subjected to Agency's review and approval for publication. NR 11 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0360-1234 EI 1532-4109 J9 J ENVIRON SCI HEAL B JI J. Environ. Sci. Health Part B-Pestic. Contam. Agric. Wastes PY 2016 VL 51 IS 11 BP 751 EP 759 DI 10.1080/03601234.2016.1198640 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DX6YF UT WOS:000384531300004 PM 27383064 ER PT J AU Verma, S Baig, RBN Nadagouda, MN Varma, RS AF Verma, Sanny Baig, R. B. Nasir Nadagouda, Mallikarjuna N. Varma, Rajender S. TI Titanium-based zeolitic imidazolate framework for chemical fixation of carbon dioxide SO GREEN CHEMISTRY LA English DT Article ID METAL-ORGANIC FRAMEWORK; HETEROGENEOUS CATALYST; CYCLIC CARBONATES; CO2; EFFICIENT; CAPTURE; CONVERSION; HYDROGENATION; TECHNOLOGIES; EPOXIDES AB A titanium-based zeolitic imidazolate framework (Ti-ZIF) with high surface area and porous morphology was synthesized and its efficacy was demonstrated in the synthesis of cyclic carbonates from epoxides and carbon dioxide. C1 [Verma, Sanny; Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU U.S. Department of Energy; U.S. Environmental Protection Agency FX SV and RBNB were supported by the Postgraduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 34 TC 3 Z9 3 U1 16 U2 16 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 18 BP 4855 EP 4858 DI 10.1039/c6gc01648k PG 4 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DW9RJ UT WOS:000383999300004 ER PT J AU Pleil, JD Sobus, JR AF Pleil, Joachim D. Sobus, Jon R. TI Estimating central tendency from a single spot measure: A closed-form solution for lognormally distributed biomarker data for risk assessment at the individual level SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID BIOMONITORING DATA; EXPOSURE; HEALTH; VARIABILITY; PERSPECTIVE; ASPHALT; WORKERS; BREATH; AIR AB Exposure-based risk assessment employs large cross-sectional data sets of environmental and biomarker measurements to predict population statistics for adverse health outcomes. The underlying assumption is that long-term (many years) latency health problems including cancer, autoimmune and cardiovascular disease, diabetes, and asthma are triggered by lifetime exposures to environmental stressors that interact with the genome. The aim of this study was to develop a specific predictive method that provides the statistical parameters for chronic exposure at the individual level based upon a single spot measurement and knowledge of global summary statistics as derived from large data sets. This is a profound shift in exposure and health statistics in that it begins to answer the question How large is my personal risk? rather than just providing an overall population-based estimate. This approach also holds value for interpreting exposure-based risks for small groups of individuals within a community in comparison to random individuals from the general population. C1 [Pleil, Joachim D.; Sobus, Jon R.] US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. RP Pleil, JD (reprint author), US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. EM pleil@unc.edu FU U.S. Environmental Protection Agency FX The authors are employees of the U.S. Environmental Protection Agency, which funded and managed the research described. NR 39 TC 0 Z9 0 U1 4 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2016 VL 79 IS 18 BP 837 EP 847 DI 10.1080/15287394.2016.1193108 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DW8MM UT WOS:000383910100005 PM 27587289 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Real-Time Environmental Monitoring Sensors and Systems Introduction SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Editorial Material; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 1 EP 14 PG 14 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800002 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Sensors and Transducers: Basic Circuits SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 17 EP 55 PG 39 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800003 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Real-Time Environmental Monitoring Sensors and Systems Preface SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Editorial Material; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP XXVII EP + PG 11 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800001 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Sensors and Transducers: Bridge Circuits SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 57 EP 78 PG 22 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800004 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Signal Conditioning and Analog-to-Digital Converters SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 79 EP 96 PG 18 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800005 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Data Acquisition Systems SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 97 EP 117 PG 21 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800006 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Single-Board Computers and Microcontrollers SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 119 EP 138 PG 20 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800007 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Wireless Technologies and Telemetry SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 139 EP 158 PG 20 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800008 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Wireless Sensor Networks SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 159 EP 173 PG 15 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800009 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Power SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 175 EP 204 PG 30 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800010 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Databases and Web Access SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 205 EP 222 PG 18 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800011 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Atmospheric Monitoring SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 225 EP 250 PG 26 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800012 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Hydrology, Hydrodynamics, Water Quality, and Aquatic Ecosystems SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 251 EP 268 PG 18 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800013 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Terrestrial Ecosystems SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 269 EP 288 PG 20 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800014 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Wildlife Monitoring SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Article; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 289 EP 300 PG 12 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800015 ER PT B AU Acevedo, MF AF Acevedo, Miguel F. BA Acevedo, MF BF Acevedo, MF TI Real-Time Environmental Monitoring Sensors and Systems Introduction to R SO REAL-TIME ENVIRONMENTAL MONITORING: SENSORS AND SYSTEMS LA English DT Editorial Material; Book Chapter C1 [Acevedo, Miguel F.] Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. [Acevedo, Miguel F.] Univ Los Andes, Sch Syst Engn, Grad Program Trop Ecol, Merida, Venezuela. [Acevedo, Miguel F.] Univ Los Andes, Ctr Simulat & Modeling CESIMO, Merida, Venezuela. [Acevedo, Miguel F.] US EPA, Sci Advisory Board, Washington, DC 20460 USA. RP Acevedo, MF (reprint author), Univ North Texas, Dept Geog, Grad Program Environm Sci, Dept Biol, Denton, TX 76203 USA.; Acevedo, MF (reprint author), Univ North Texas, Dept Elect Engn, Denton, TX 76203 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-4034-4; 978-1-4822-4020-7 PY 2016 BP 301 EP 332 PG 32 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BF6FW UT WOS:000383034800016 ER PT J AU Whiteside, TS Hilal, SH Brenner, A Carreira, LA AF Whiteside, T. S. Hilal, S. H. Brenner, A. Carreira, L. A. TI Estimating the melting point, entropy of fusion, and enthalpy of fusion of organic compounds via SPARC SO SAR AND QSAR IN ENVIRONMENTAL RESEARCH LA English DT Article DE Entropy of fusion; enthalpy of fusion; melting point; organic compounds; SPARC ID THERMODYNAMIC PROPERTIES; PHASE-TRANSITIONS; N-PROPYL; AZOBENZENES; COEFFICIENT; PREDICTION; MOLECULES; SERIES; ACIDS AB The entropy of fusion, enthalpy of fusion, and melting point of organic compounds can be estimated through three models developed using the SPARC (SPARC Performs Automated Reasoning in Chemistry) platform. The entropy of fusion is modelled through a combination of interaction terms and physical descriptors. The enthalpy of fusion is modelled as a function of the entropy of fusion, boiling point, and flexibility of the molecule. The melting point model is the enthalpy of fusion divided by the entropy of fusion. These models were developed in part to improve SPARC's vapour pressure and solubility models. These models have been tested on 904 unique compounds. The entropy model has a RMS of 12.5 J mol(-1) K-1. The enthalpy model has a RMS of 4.87 kJ mol(-1). The melting point model has a RMS of 54.4 degrees C. C1 [Whiteside, T. S.] Savannah River Natl Lab, Savannah River Site, Aiken, SC 29808 USA. [Hilal, S. H.] US EPA, Athens, GA USA. [Brenner, A.; Carreira, L. A.] Univ Georgia, Dept Chem, Athens, GA 30602 USA. RP Whiteside, TS (reprint author), Savannah River Natl Lab, Savannah River Site, Aiken, SC 29808 USA. EM tad.whiteside@srnl.doe.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 30 TC 0 Z9 0 U1 3 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1062-936X EI 1029-046X J9 SAR QSAR ENVIRON RES JI SAR QSAR Environ. Res. PY 2016 VL 27 IS 8 BP 677 EP 701 DI 10.1080/1062936X.2016.1217270 PG 25 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Environmental Sciences; Mathematical & Computational Biology; Toxicology SC Chemistry; Computer Science; Environmental Sciences & Ecology; Mathematical & Computational Biology; Toxicology GA DW6NT UT WOS:000383768800005 PM 27586365 ER PT J AU Hance, DJ Ganio, LM Burnett, KM Ebersole, JL AF Hance, Dalton J. Ganio, Lisa M. Burnett, Kelly M. Ebersole, Joseph L. TI Basin-Scale Variation in the Spatial Pattern of Fall Movement of Juvenile Coho Salmon in the West Fork Smith River, Oregon SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID ONCORHYNCHUS-KISUTCH; STREAM NETWORK; OVERWINTER SURVIVAL; SEASONAL-CHANGES; HABITAT USE; ECOLOGY; CONSERVATION; LANDSCAPES; STEELHEAD; SUMMER AB For several species of salmonids, Oncorhynchus and Salvelinus spp., inhabiting Pacific coastal temperate streams, juvenile fish have been recorded moving between main-stem and tributary habitats during the transition from the summer dry season to the winter wet season. Movement connecting summer and winter habitats may be particularly important for Coho Salmon O. kisutch because availability of overwintering habitat can limit freshwater survival for this species. Here, we describe basin-scale variability in movement between main-stem and tributary habitat for juvenile Coho Salmon tagged in the summer with PIT tags and detected in the fall at four stationary detection sites at tributary-main-stem confluences of the West Fork Smith River, Oregon. We used odds ratios to evaluate spatial patterns in tributary-main-stem movement across tributary junctions at upper-river, midriver, and lower-river locations. Three types of movement were assessed: (1) emigration out of tributaries into the main stem, (2) immigration into a tributary from the main stem downstream from the tributary junction, and (3) immigration from the main stem upstream from the tributary junction. The likelihood of emigration had a distinct spatial pattern. Only at the two upper-river detection sites were juvenile Coho Salmon more likely to emigrate than immigrate. Fish immigrating into a midriver tributary were more likely to originate from the main stem downstream from the confluence, whereas fish immigrating into two lower-river tributaries were more likely to originate from the main stem upstream from the confluence. This basin-scale variation in patterns of immigration and emigration demonstrates complexity in the connectivity of juvenile Coho Salmon seasonal habitats within a stream network. We conclude that effective restoration planning and watershed management should account for the spatial pattern of connectivity of summer-rearing and overwintering habitat throughout a stream network and consider the full diversity of movement patterns that may be required for fish to access seasonal habitats. C1 [Hance, Dalton J.] Anchor QEA LLC, 23 South Wenatchee Ave,Suite 220, Wenatchee, WA 98801 USA. [Ganio, Lisa M.] Oregon State Univ, Dept Forest Ecosyst & Soc, 321 Richardson Hall, Corvallis, OR 97331 USA. [Burnett, Kelly M.] US Forest Serv, Pacific Northwest Res Stn, 3200 Southwest Jefferson Way, Corvallis, OR 97331 USA. [Ebersole, Joseph L.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 200 Southwest 35th St, Corvallis, OR 97333 USA. RP Hance, DJ (reprint author), Anchor QEA LLC, 23 South Wenatchee Ave,Suite 220, Wenatchee, WA 98801 USA. EM dhance@anchorqea.com FU U.S. Environmental Protection Agency; American Recovery and Reinvestment Act FX We thank George Weaver for insightful conversations about detection probabilities and Nick Som for valuable comments on earlier drafts. This work could not have been accomplished without the excellent fieldwork performed by John Bartosz, Sharon Crowley, Sheila Davis, Loretta Ellenburg, Steve Hendricks, Hank Lavigne, Tyler Mintkeski, Stefanie Orlaineta, Clayton Oyler, Nancy Raskauskas, Chad Meengs, Jason Meyers, Ross St. Clair, Candace Wallace, Sara Lampson, and Michael Zenthoefer. Patti Haggerty provided GIS coverages. Zheng Fang assisted with figure production. Bruce Hansen was instrumental in the deployment and maintenance of stationary PIT tag detection sites. The information in this document has been funded by the U.S. Environmental Protection Agency and the American Recovery and Reinvestment Act. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and by the U.S. Forest Service, Pacific Northwest Research Station and approved for publication. Approval does not signify that the contents reflect the views of the agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 46 TC 0 Z9 0 U1 5 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PY 2016 VL 145 IS 5 BP 1018 EP 1034 DI 10.1080/00028487.2016.1194892 PG 17 WC Fisheries SC Fisheries GA DV2KU UT WOS:000382750200009 ER PT J AU Liu, HB Sonntag, D Brzezinski, D Fulper, CR Hawkins, D Warila, JE AF Liu, Haobing Sonntag, Darrell Brzezinski, David Fulper, Carl R. Hawkins, David Warila, James E. TI Operations and Emissions Characteristics of Light-Duty Vehicles on Ramps SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Ramps serve as the connections between restricted access highways and other road facilities, and considering the intensity of acceleration and deceleration occurring on ramps, the operation on ramps may contribute a significant amount of criteria-pollutant and greenhouse gas emissions from highway operation. In this study, second-by-second speed and position data were collected from 10 vehicles in the Detroit, Michigan, metropolitan area during their daily commute trips in 2012 using a portable activity measurement system. Ramp-associated operations were extracted from these measurements using ArcGIS, and emission rates were assigned based on model runs of the MOtor Vehicle Emission Simulator, or MOVES. In general, emissions of light-duty vehicles estimated for ramp operation are about two to three times higher than those for highway operation (excluding ramps) and local cycles with average speed levels higher than 30 mph. Emissions for interchange ramps are estimated to be similar to highway emissions. Accelerations occurring immediately after vehicles enter the highway from on-ramps contribute a large portion of emissions from ramp operations, since high-power operations are involved. This point applies especially to loop on-ramps, where the emission rate immediately after entering the highways tends to be higher than driving within the physical ramp itself. This research will be useful for understanding basic ramp operation characteristics and their emissions effects, and it will be important for development of ramp classification systems and generic ramp driving cycles, for emissions modeling and ramp hot-spot analysis. C1 [Liu, Haobing] Georgia Inst Technol, Sch Civil & Environm Engn, 790 Atlantic Dr, Atlanta, GA 30332 USA. [Sonntag, Darrell; Brzezinski, David; Fulper, Carl R.; Hawkins, David; Warila, James E.] US EPA, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA. RP Liu, HB (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, 790 Atlantic Dr, Atlanta, GA 30332 USA. EM Heobing.Liu@gatech.edu OI Liu, Henry/0000-0002-3685-9920 FU Oak Ridge Institute for Science and Education's participant research program - U.S. Environmental Protection Agency; Oak Ridge Institute for Science and Education's participant research program - U.S. Department of Energy FX This work was supported in part by the appointment of the first author to the Oak Ridge Institute for Science and Education's participant research program funded through an interagency agreement between the U.S. Environmental Protection Agency and the U.S. Department of Energy. The authors acknowledge Zuimdie Guerra and Kent Helmer of the U.S. Environmental Protection Agency for their support in the data collection and for providing the PAMS data. The authors also acknowledge the recommendations by other members of the MOVES team, specifically Andrew Eilbert (Oak Ridge Institute for Science and Education participant), Megan Beardsley, and Edward Nam. NR 4 TC 0 Z9 0 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 EI 2169-4052 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2016 IS 2570 BP 1 EP 11 DI 10.3141/2570-01 PG 11 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA DV0HH UT WOS:000382598100002 ER PT J AU Baig, RBN Verma, S Nadagouda, MN Varma, RS AF Baig, R. B. Nasir Verma, Sanny Nadagouda, Mallikarjuna N. Varma, Rajender S. TI Advancing Sustainable Catalysis with Magnetite. Surface Modification and Synthetic Applications SO ALDRICHIMICA ACTA LA English DT Article DE green chemistry; recyclability; organic synthesis; heterogeneous catalysis; magnetic separation; magnetite ID TRANSITION-METAL CATALYSIS; HOMOGENEOUS CATALYSIS; ORGANIC-SYNTHESIS; PD-CATALYST; NANOPARTICLES; NANOCATALYST; OXIDATION; EFFICIENT; ACID AB This article surveys the recent developments in the synthesis, surface modification, and synthetic applications of magnetite nanoparticles. The emergence of iron(II,III) oxide (triiron tetraoxide or magnetite; Fe3O4, or FeO center dot Fe2O3) nanoparticles as a sustainable support in heterogeneous catalysis is highlighted. C1 [Baig, R. B. Nasir; Verma, Sanny; Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, WSWRD, WQMB, MS 443, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU National Risk Management Research Laboratory FX R. B. N. B. and S. V. were supported by the Postgraduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 39 TC 0 Z9 0 U1 10 U2 10 PU ALDRICH CHEMICAL CO INC PI MILWAUKEE PA 1001 WEST SAINT PAUL AVE, MILWAUKEE, WI 53233 USA SN 0002-5100 J9 ALDRICHIM ACTA JI Aldrichimica Acta PY 2016 VL 49 IS 2 BP 35 EP 41 PG 7 WC Chemistry, Organic SC Chemistry GA DT6KZ UT WOS:000381594400002 ER PT J AU Edwards, S Oki, N Bell, S Nelms, M Tan, C AF Edwards, Stephen Oki, Noffisat Bell, Shannon Nelms, Mark Tan, Cecelia TI Computationally-predicted aops and systems toxicology SO DRUG METABOLISM REVIEWS LA English DT Meeting Abstract CT 20th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) CY OCT 18-22, 2015 CL Orlando, FL SP Int Soc Study Xenobiot C1 [Edwards, Stephen; Oki, Noffisat; Bell, Shannon; Nelms, Mark; Tan, Cecelia] US EPA, Res Triangle Pk, NC 27711 USA. [Oki, Noffisat; Bell, Shannon; Nelms, Mark] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0360-2532 EI 1097-9883 J9 DRUG METAB REV JI Drug Metab. Rev. PY 2016 VL 48 SU 1 MA S13 BP 12 EP 12 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DS4IO UT WOS:000380744900020 ER PT J AU Richardson, VM Mazur, CS AF Richardson, Vicki M. Mazur, Christopher S. TI Evaluating thyroxine metabolism and transport in primary rat and human hepatocytes following BDE 47 exposure SO DRUG METABOLISM REVIEWS LA English DT Meeting Abstract CT 20th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) CY OCT 18-22, 2015 CL Orlando, FL SP Int Soc Study Xenobiot C1 [Richardson, Vicki M.] US EPA, Res Triangle Pk, NC 27711 USA. [Mazur, Christopher S.] US EPA, Athens, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0360-2532 EI 1097-9883 J9 DRUG METAB REV JI Drug Metab. Rev. PY 2016 VL 48 SU 1 MA P186 BP 114 EP 114 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DS4IO UT WOS:000380744900236 ER PT J AU Anastas, ND AF Anastas, Nicholas D. TI Connecting toxicology and chemistry to ensure safer chemical design SO GREEN CHEMISTRY LA English DT Article ID ADVERSE OUTCOME PATHWAYS; RISK-ASSESSMENT; TOXICITY; SUPPORT; PREDICTION; FRAMEWORK; HAZARD; TOOLS AB Designing safer, healthier and sustainable products and processes requires the engagement of toxicologists and the incorporation of twenty-first century toxicology principles and practices. As the demand for safer products increases, scientists must incorporate toxicology as early as possible as part of a comprehensive design strategy to minimize or eliminate toxicity prior to product development. Hazard reduction through molecular design benefits from trans-disciplinary collaboration among chemists, toxicologists and environmental scientists, and must be initiated at the design stage of chemicals synthesis. The path forward requires a sustained multi-pronged commitment to embedding the principles of toxicology into the chemistry curriculum, developing a framework that articulates maxims for sustainable design, promoting research collaboration among allied professional scientists and supporting education and outreach efforts at every opportunity, to technical and non-technical audiences, that highlight the natural nexus between toxicology and chemistry. C1 [Anastas, Nicholas D.] NRMRL, Cincinnati, OH 45268 USA. [Anastas, Nicholas D.] US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Anastas, ND (reprint author), NRMRL, Cincinnati, OH 45268 USA.; Anastas, ND (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA. EM anastas.nicholas@epa.gov NR 37 TC 1 Z9 1 U1 5 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 16 BP 4325 EP 4331 DI 10.1039/c6gc00758a PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DT4HM UT WOS:000381440800002 ER PT J AU DeVito, SC AF DeVito, Stephen C. TI On the design of safer chemicals: a path forward SO GREEN CHEMISTRY LA English DT Article ID GREEN CHEMISTRY; HAZARD; UPDATE AB The need for chemists to design chemicals that not only fulfill their intended purposes but are of minimal hazard was recognized nearly a century ago. Over the decades regulations pertaining to the development of safer drug substances and pesticides have been promulgated, and caused changes in the relationships between industry, academia, government agencies, and how chemists are trained to develop new pesticides and new drug substances. This has led to the considerable progress that has occurred over the past 60 years in the development of safe and efficacious pharmaceuticals and pesticides. Progress in the design of safer commercial chemicals, however, has been comparatively slow, despite the many advances in: toxicological research; the elucidation of mechanisms of toxicity; and the identification of relationships between chemical structure, physicochemical and electronic properties with toxicity, environmental fate, or environmental hazard. While few would argue against the need for safer commercial chemicals, implementation of the design of safer chemicals as a paradigm has not advanced to the same extent as other approaches to preventing pollution. This article offers insights on how this paradigm can be advanced as an important component of sustainable development, and how those existing commercial chemicals for which safer, commercially viable alternatives are most needed can be identified and prioritized. One recommendation regarding prioritization is the use of information available in the United States (U.S.) Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI): the U.S. pollutant release and transfer register (PRTR). The TRI is an easy-to-use pollution prevention database tool used extensively for tracking the quantities of toxic chemicals annually released or otherwise managed as waste, and evaluating overall environmental performance by industrial facilities. Other PRTRs throughout the world have the potential to be used for identification and prioritization of chemicals as well. C1 [DeVito, Stephen C.] US EPA, Tox Release Inventory Program, Mail Code 7409 M, Washington, DC 20460 USA. RP DeVito, SC (reprint author), US EPA, Tox Release Inventory Program, Mail Code 7409 M, Washington, DC 20460 USA. EM devito.steve@epa.gov NR 56 TC 2 Z9 2 U1 9 U2 9 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 16 BP 4332 EP 4347 DI 10.1039/c6gc00526h PG 16 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DT4HM UT WOS:000381440800003 ER PT J AU Shen, LZQ Judson, RS Melnikov, F Roethle, J Gudibanda, A Zimmerman, JB Anastas, PT AF Shen, Longzhu Q. Judson, Richard S. Melnikov, Fjodor Roethle, John Gudibanda, Aditya Zimmerman, Julie B. Anastas, Paul T. TI Probabilistic diagram for designing chemicals with reduced potency to incur cytotoxicity SO GREEN CHEMISTRY LA English DT Article ID ACUTE AQUATIC TOXICITY; COMPUTATIONAL TOXICOLOGY; ENVIRONMENTAL CHEMICALS; PYTHON; MECHANISMS; PREDICTION; PLATFORM AB Toxicity is a concern with many chemicals currently in commerce, and with new chemicals that are introduced each year. The standard approach to testing chemicals is to run studies in laboratory animals (e.g. rats, mice, dogs), but because of the expense of these studies and concerns for animal welfare, few chemicals besides pharmaceuticals and pesticides are fully tested. Over the last decade there have been significant developments in the field of computational toxicology which combines in vitro tests and computational models. The ultimate goal of this field is to test all chemicals in a rapid, cost effective manner with minimal use of animals. One of the simplest measures of toxicity is provided by high-throughput in vitro cytotoxicity assays, which measure the concentration of a chemical that kills particular types of cells. Chemicals that are cytotoxic at low concentrations tend to be more toxic to animals than chemicals that are less cytotoxic. We employed molecular characteristics derived from density functional theory (DFT) and predicted values of log(octanol-water partition coefficient) (log P) to construct a design variable space, and built a predictive model for cytotoxicity based on U.S. EPA Toxicity ForeCaster (ToxCast) data tested up to 100 mu M using a Naive Bayesian algorithm. External evaluation showed that the area under the curve (AUC) for the receiver operating characteristic (ROC) of the model to be 0.81. Using this model, we provide probabilistic design rules to help synthetic chemists minimize the chance that a newly synthesized chemical will be cytotoxic. C1 [Shen, Longzhu Q.; Melnikov, Fjodor; Zimmerman, Julie B.; Anastas, Paul T.] Sch Forestry & Environm Studies, New Haven, CT 06511 USA. [Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Roethle, John] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06511 USA. [Gudibanda, Aditya] Yale Univ, Dept Comp Sci, New Haven, CT 06511 USA. RP Anastas, PT (reprint author), Sch Forestry & Environm Studies, New Haven, CT 06511 USA. EM paul.anastas@yale.edu FU EPA/NSF Networks for Sustainable Molecular Design and Synthesis; QAFCO FX This research is supported by EPA/NSF Networks for Sustainable Molecular Design and Synthesis. PTA would like to express appreciation to QAFCO for funding support. The authors would like to thank for the helpful discussions with Dr Yan Zhang, Dr Imran Shah, Dr Declan Clarke, and Dr Philip Coish. The authors acknowledged the computational support provided by Dr William Jorgensen, Dr Julian Tirado-Rives and Yale high performance computing platform. NR 54 TC 1 Z9 1 U1 7 U2 7 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 16 BP 4461 EP 4467 DI 10.1039/c6gc01058j PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DT4HM UT WOS:000381440800012 ER PT J AU Bock, AR Hay, LE McCabe, GJ Markstrom, SL Atkinson, RD AF Bock, Andrew R. Hay, Lauren E. McCabe, Gregory J. Markstrom, Steven L. Atkinson, R. Dwight TI Parameter regionalization of a monthly water balance model for the conterminous United States SO HYDROLOGY AND EARTH SYSTEM SCIENCES LA English DT Article ID COUPLED REACTION SYSTEMS; SENSITIVITY-ANALYSIS; UNGAUGED CATCHMENTS; RATE COEFFICIENTS; HYDROLOGIC MODEL; SWAT MODEL; CALIBRATION; VALIDATION; UNCERTAINTIES; PRECIPITATION AB A parameter regionalization scheme to transfer parameter values from gaged to ungaged areas for a monthly water balance model (MWBM) was developed and tested for the conterminous United States (CONUS). The Fourier Amplitude Sensitivity Test, a global-sensitivity algorithm, was implemented on a MWBM to generate parameter sensitivities on a set of 109 951 hydrologic response units (HRUs) across the CONUS. The HRUs were grouped into 110 calibration regions based on similar parameter sensitivities. Subsequently, measured runoff from 1575 streamgages within the calibration regions were used to calibrate the MWBM parameters to produce parameter sets for each calibration region. Measured and simulated runoff at the 1575 streamgages showed good correspondence for the majority of the CONUS, with a median computed Nash-Sutcliffe efficiency coefficient of 0.76 over all streamgages. These methods maximize the use of available runoff information, resulting in a calibrated CONUS-wide application of the MWBM suitable for providing estimates of water availability at the HRU resolution for both gaged and ungaged areas of the CONUS. C1 [Bock, Andrew R.] US Geol Survey, Colorado Water Sci Ctr, Denver Fed Ctr, POB 25046,MS 415, Denver, CO 80225 USA. [Hay, Lauren E.; McCabe, Gregory J.; Markstrom, Steven L.] US Geol Survey, Natl Res Program, Denver Fed Ctr, POB 25046,MS 413, Denver, CO 80225 USA. [Atkinson, R. Dwight] US EPA, Off Water 4503T, 1200 Penn Ave, Washington, DC 20004 USA. RP Bock, AR (reprint author), US Geol Survey, Colorado Water Sci Ctr, Denver Fed Ctr, POB 25046,MS 415, Denver, CO 80225 USA. EM abock@usgs.gov FU US Department of Interior South Central Climate Science Center; US Environmental Protection Agency Office of Water; US Geological Survey WaterSMART initiative; USGS Core Science Systems (CSS) Mission Area FX This research was financially supported by the US Department of Interior South Central Climate Science Center (http://southcentralclimate.org/), US Environmental Protection Agency Office of Water, and the US Geological Survey WaterSMART initiative. This paper is a product of discussions and activities that took place at the USGS John Wesley Powell Center for Analysis and Synthesis (https://powellcenter.usgs.gov/). Further project support was provided by the Jeff Falgout of the USGS Core Science Systems (CSS) Mission Area. Any use of trade, product, or firm names is for descriptive purposes only and does not imply NR 68 TC 2 Z9 2 U1 2 U2 2 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1027-5606 EI 1607-7938 J9 HYDROL EARTH SYST SC JI Hydrol. Earth Syst. Sci. PY 2016 VL 20 IS 7 BP 2861 EP 2876 DI 10.5194/hess-20-2861-2016 PG 16 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA DS9KN UT WOS:000381101700004 ER PT J AU Ghio, AJ Schreinemachers, DM AF Ghio, Andrew J. Schreinemachers, Dina M. TI Heme Oxygenase Activity Correlates with Serum Indices of Iron Homeostasis in Healthy Nonsmokers SO BIOMARKER INSIGHTS LA English DT Article DE carbon monoxide; carboxyhemoglobin; ferritin; heme oxygenase; iron ID 2ND NATIONAL-HEALTH; CARBON-MONOXIDE; CARBOXYHEMOGLOBIN LEVELS; TOBACCO-SMOKE; AIR-POLLUTION; EXPOSURE; CELLS; METABOLISM; MECHANISMS; MORTALITY AB Heme oxygenase (HO) catalyzes the breakdown of heme to carbon monoxide, iron, and biliverdin. While the use of genetically altered animal models in investigation has established distinct associations between HO activity and systemic iron availability, studies have not yet confirmed such participation of HO in iron homeostasis of humans. Carbon monoxide produced through HO activity will bind to hemoglobin in circulating erythrocytes, and therefore, blood carboxyhemoglobin (COHb) can be used as an index of HO activity. Using the second National Health and Nutrition Examination Survey, we tested the postulate that HO activity correlates with serum indices of iron homeostasis in healthy nonsmokers. The investigation included 844 lifetime nonsmokers (586 females) 18 years of age and older in the study population. Significant correlations were demonstrated between COHb and several indices of iron homeostasis including serum levels of both ferritin and iron and percentage iron saturation of transferrin. There was no significant association between COHb and hemoglobin, the largest repository of heme in the human body, which functions as the substrate for HO. We conclude that HO activity contributes to human iron homeostasis with significant correlations between COHb and serum ferritin and iron levels and percentage iron saturation of transferrin. C1 [Ghio, Andrew J.; Schreinemachers, Dina M.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. RP Ghio, AJ (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. EM ghio.andy@epa.gov NR 46 TC 0 Z9 0 U1 0 U2 0 PU LIBERTAS ACAD PI AUCKLAND PA PO BOX 300-874, ALBANY 0752, AUCKLAND, 00000, NEW ZEALAND SN 1177-2719 J9 BIOMARK INSIGHTS JI Biomark. Insights PY 2016 VL 11 BP 49 EP 54 DI 10.4137/BMIMI.S36226 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA DR8OD UT WOS:000380156300001 PM 27199547 ER PT J AU Sather, ME Cavender, K AF Sather, Mark E. Cavender, Kevin TI Trends analyses of 30 years of ambient 8 hour ozone and precursor monitoring data in the South Central US: progress and challenges SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID UNITED-STATES; AIR-QUALITY; INDUSTRIAL EMISSIONS; CLIMATE-CHANGE; 8-HOUR OZONE; URBAN AREAS; HOUSTON; VARIABILITY; POLLUTION; PERIOD AB In the last 30 years ambient ozone concentrations have notably decreased in the South Central U.S. Yet, current ambient ozone concentrations measured over the past three years 2013-2015 in this area of the U.S. are not meeting the U.S. 2015 8 hour ozone standard of 70 parts per billion (ppb). This paper provides an update on long-term trends analyses of ambient 8 hour ozone and ozone precursor monitoring data collected over the past 30 years (1986-2015) in four South Central U.S. cities, following up on two previously published reviews of 20 and 25 year trends for these cities. All four cities have benefitted from national ozone precursor controls put in place during the 1990s and 2000s involving cleaner vehicles (vehicle fleet turnover/replacement over time), cleaner fuels, cleaner gasoline and diesel engines, and improved inspection/maintenance programs for existing vehicles. Additional ozone precursor emission controls specific to each city are detailed in this paper. The controls have resulted in impressive ambient ozone and ambient ozone precursor concentration reductions in the four South Central U.S. cities over the past 30 years, including 31-70% ambient nitrogen oxides (NOx) concentration declines from historical peaks to the present, 43-72% volatile organic compound (VOC) concentration declines from historical peaks to the present, a related 45-76% VOC reactivity decline for a subset of VOC species from historical peaks to the present, and an 18-38 ppb reduction in city 8 hour ozone design value concentrations. A new challenge for each of the four South Central U.S. cities will be meeting the U.S. 2015 8 hour ozone standard of 70 ppb. C1 [Sather, Mark E.] US EPA Reg 6, Air Monitoring & Grants Sect, 1445 Ross Ave, Dallas, TX 75202 USA. [Cavender, Kevin] US EPA, Air Qual Assessment Div, Off Air Qual Planning & Stand, Mail Code C304-06, Res Triangle Pk, NC 27711 USA. RP Sather, ME (reprint author), US EPA Reg 6, Air Monitoring & Grants Sect, 1445 Ross Ave, Dallas, TX 75202 USA. EM sather.mark@epa.gov NR 38 TC 1 Z9 1 U1 5 U2 10 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PY 2016 VL 18 IS 7 BP 819 EP 831 DI 10.1039/c6em00210b PG 13 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA DR5KE UT WOS:000379941100006 PM 27282109 ER PT J AU Gomez-Alvarez, V Pfaller, S Pressman, JG Wahman, DG Revetta, RP AF Gomez-Alvarez, V. Pfaller, S. Pressman, J. G. Wahman, D. G. Revetta, R. P. TI Resilience of microbial communities in a simulated drinking water distribution system subjected to disturbances: role of conditionally rare taxa and potential implications for antibiotic-resistant bacteria SO ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY LA English DT Article ID DIVERSITY; BIOFILMS; SEQUENCE; ECOLOGY; QUALITY; NITRIFICATION; DISINFECTANTS; ALIGNMENT; DYNAMICS; NETWORK AB Many US water utilities using chloramine as their secondary disinfectant have experienced nitrification episodes that detrimentally impact water quality in their distribution systems. A semi-closed pipe-loop chloraminated drinking water distribution system (DWDS) simulator was used to evaluate the biological stability of the system and describe the response of microbial communities in the bulk water (BW) and biofilm (BF) phase to a disturbance caused by changes in the operational parameters. The DWDS simulator was operated through five successive operational schemes, including an episode of nitrification, followed by a 'chlorine burn' by switching the disinfectant from chloramine to free chlorine. Community comparisons showed significant differences in the structure based on disinfectant and phase (e.g., BW and BF). Both disturbances created changes in the relative abundances of the core microbiome and some members of the rare biosphere (i.e., conditionally rare taxa); however, the microbial community was resilient and returned to its stable state. Genes associated with multiple antibiotic resistance mechanisms were found to be a component of the core genomes of waterborne isolates. These results provide evidence of variations in the bulk water/biofilm microbial community structure during episodes of disturbance (e.g., disinfectant switching practices, nitrification) and its recovery after disturbance. C1 [Gomez-Alvarez, V.; Pfaller, S.; Pressman, J. G.; Wahman, D. G.; Revetta, R. P.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Revetta, RP (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM Revetta.Randy@epa.gov NR 69 TC 1 Z9 1 U1 11 U2 14 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2053-1400 EI 2053-1419 J9 ENVIRON SCI-WAT RES JI Environ. Sci.-Wat. Res. Technol. PY 2016 VL 2 IS 4 BP 645 EP 657 DI 10.1039/c6ew00053c PG 13 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DR4KF UT WOS:000379869600007 ER PT J AU Bash, JO Baker, KR Beaver, MR AF Bash, Jesse O. Baker, Kirk R. Beaver, Melinda R. TI Evaluation of improved land use and canopy representation in BEIS v3.61 with biogenic VOC measurements in California SO GEOSCIENTIFIC MODEL DEVELOPMENT LA English DT Article ID SECONDARY ORGANIC AEROSOL; AIRBORNE FLUX MEASUREMENTS; PARTICULATE AIR-POLLUTION; CMAQ MODELING SYSTEM; UNITED-STATES; PHOTOCHEMICAL MODEL; ISOPRENE EMISSIONS; SURFACE; PREDICTIONS; INVENTORY AB Biogenic volatile organic compounds (BVOC) participate in reactions that can lead to secondarily formed ozone and particulate matter (PM) impacting air quality and climate. BVOC emissions are important inputs to chemical transport models applied on local to global scales but considerable uncertainty remains in the representation of canopy parameterizations and emission algorithms from different vegetation species. The Biogenic Emission Inventory System (BEIS) has been used to support both scientific and regulatory model assessments for ozone and PM. Here we describe a new version of BEIS which includes updated input vegetation data and canopy model formulation for estimating leaf temperature and vegetation data on estimated BVOC. The Biogenic Emission Landuse Database (BELD) was revised to incorporate land use data from the Moderate Resolution Imaging Spectroradiometer (MODIS) land product and 2006 National Land Cover Database (NLCD) land coverage. Vegetation species data are based on the US Forest Service (USFS) Forest Inventory and Analysis (FIA) version 5.1 for 2002-2013 and US Department of Agriculture (USDA) 2007 census of agriculture data. This update results in generally higher BVOC emissions throughout California compared with the previous version of BEIS. Baseline and updated BVOC emission estimates are used in Community Multiscale Air Quality (CMAQ) Model simulations with 4aEuro-km grid resolution and evaluated with measurements of isoprene and monoterpenes taken during multiple field campaigns in northern California. The updated canopy model coupled with improved land use and vegetation representation resulted in better agreement between CMAQ isoprene and monoterpene estimates compared with these observations. C1 [Bash, Jesse O.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Baker, Kirk R.; Beaver, Melinda R.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Bash, JO (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM bash.jesse@epa.gov NR 66 TC 4 Z9 4 U1 5 U2 7 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1991-959X EI 1991-9603 J9 GEOSCI MODEL DEV JI Geosci. Model Dev. PY 2016 VL 9 IS 6 BP 2191 EP 2207 DI 10.5194/gmd-9-2191-2016 PG 17 WC Geosciences, Multidisciplinary SC Geology GA DQ7RB UT WOS:000379404000010 ER PT J AU Rumsey, IC Walker, JT AF Rumsey, Ian C. Walker, John T. TI Application of an online ion-chromatography-based instrument for gradient flux measurements of speciated nitrogen and sulfur SO ATMOSPHERIC MEASUREMENT TECHNIQUES LA English DT Article ID EDDY-COVARIANCE; EXCHANGE FLUXES; AMBIENT AIR; MASS-SPECTROMETRY; SURFACE-EXCHANGE; PEROXY NITRATES; AEROSOL; AMMONIA; DENUDER; HNO3 AB The dry component of total nitrogen and sulfur atmospheric deposition remains uncertain. The lack of measurements of sufficient chemical speciation and temporal extent make it difficult to develop accurate mass budgets and sufficient process level detail is not available to improve current air-surface exchange models. Over the past decade, significant advances have been made in the development of continuous air sampling measurement techniques, resulting with instruments of sufficient sensitivity and temporal resolution to directly quantify air-surface exchange of nitrogen and sulfur compounds. However, their applicability is generally restricted to only one or a few of the compounds within the deposition budget. Here, the performance of the Monitor for AeRosols and GAses in ambient air (MARGA 2S), a commercially available online ion-chromatography-based analyzer is characterized for the first time as applied for air-surface exchange measurements of HNO3, NH3, NH4+, NO3-, SO2 and SO42-. Analytical accuracy and precision are assessed under field conditions. Chemical concentrations gradient precision are determined at the same sampling site. Flux uncertainty measured by the aerodynamic gradient method is determined for a representative 3-week period in fall 2012 over a grass field. Analytical precision and chemical concentration gradient precision were found to compare favorably in comparison to previous studies. During the 3-week period, percentages of hourly chemical concentration gradients greater than the corresponding chemical concentration gradient detection limit were 86, 42, 82, 73, 74 and 69% for NH3, NH4+, HNO3, NO3-, SO2 and SO42-, respectively. As expected, percentages were lowest for aerosol species, owing to their relatively low deposition velocities and correspondingly smaller gradients relative to gas phase species. Relative hourly median flux uncertainties were 31, 121, 42, 43, 67 and 56% for NH3, NH4+, HNO3, NO3-, SO2 and SO42-, respectively. Flux uncertainty is dominated by uncertainty in the chemical concentrations gradients during the day but uncertainty in the chemical concentration gradients and transfer velocity are of the same order at night. Results show the instrument is sufficiently precise for flux gradient applications. C1 [Rumsey, Ian C.] Coll Charleston, Dept Phys & Astron, Charleston, SC 29401 USA. [Walker, John T.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Rumsey, IC (reprint author), Coll Charleston, Dept Phys & Astron, Charleston, SC 29401 USA. EM rumseyic@cofc.edu NR 29 TC 0 Z9 0 U1 9 U2 9 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1867-1381 EI 1867-8548 J9 ATMOS MEAS TECH JI Atmos. Meas. Tech. PY 2016 VL 9 IS 6 BP 2581 EP 2592 DI 10.5194/amt-9-2581-2016 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DQ7OM UT WOS:000379397100008 ER PT J AU Nowlan, CR Liu, X Leitch, J Chance, K Abad, GG Liu, C Zoogman, P Cole, J Delker, T Good, W Murcray, F Ruppert, L Soo, D Follette-Cook, MB Janz, SJ Kowalewski, MG Loughner, CP Pickering, KE Herman, JR Beaver, MR Long, RW Szykman, JJ Judd, LM Kelley, P Luke, WT Ren, XR Al-Saadi, JA AF Nowlan, Caroline R. Liu, Xiong Leitch, JamesW. Chance, Kelly Abad, Gonzalo Gonzalez Liu, Cheng Zoogman, Peter Cole, Joshua Delker, Thomas Good, William Murcray, Frank Ruppert, Lyle Soo, Daniel Follette-Cook, Melanie B. Janz, Scott J. Kowalewski, Matthew G. Loughner, Christopher P. Pickering, Kenneth E. Herman, Jay R. Beaver, Melinda R. Long, Russell W. Szykman, James J. Judd, Laura M. Kelley, Paul Luke, Winston T. Ren, Xinrong Al-Saadi, Jassim A. TI Nitrogen dioxide observations from the Geostationary Trace gas and Aerosol Sensor Optimization (GeoTASO) airborne instrument: Retrieval algorithm and measurements during DISCOVER-AQ Texas 2013 SO ATMOSPHERIC MEASUREMENT TECHNIQUES LA English DT Article ID OZONE MONITORING INSTRUMENT; IMAGING DOAS INSTRUMENT; TROPOSPHERIC NO2 RETRIEVAL; ABSORPTION CROSS-SECTION; CMAQ MODELING SYSTEM; SATELLITE RETRIEVALS; STRATOSPHERIC OZONE; FORMALDEHYDE; OMI; SCATTERING AB The Geostationary Trace gas and Aerosol Sensor Optimization (GeoTASO) airborne instrument is a test bed for upcoming air quality satellite instruments that will measure backscattered ultraviolet, visible and near-infrared light from geostationary orbit. GeoTASO flew on the NASA Falcon aircraft in its first intensive field measurement campaign during the Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) Earth Venture Mission over Houston, Texas, in September 2013. Measurements of backscattered solar radiation between 420 and 465 nm collected on 4 days during the campaign are used to determine slant column amounts of NO2 at 250 m x 250 m spatial resolution with a fitting precision of 2.2 x 10(15) molecules cm(-2). These slant columns are converted to tropospheric NO2 vertical columns using a radiative transfer model and trace gas profiles from the Community Multiscale Air Quality (CMAQ) model. Total column NO2 from GeoTASO is well correlated with ground-based Pandora observations (r = 0 : 90 on the most polluted and cloud-free day of measurements and r = 0.74 overall), with GeoTASO NO2 slightly higher for the most polluted observations. Surface NO2 mixing ratios inferred from GeoTASO using the CMAQ model show good correlation with NO2 measured in situ at the surface during the campaign (r = 0 : 85). NO2 slant columns from GeoTASO also agree well with preliminary retrievals from the GEO-CAPE Airborne Simulator (GCAS) which flew on the NASA King Air B200 (r = 0.81, slope = 0.91). Enhanced NO2 is resolvable over areas of traffic NOx emissions and near individual petrochemical facilities. C1 [Nowlan, Caroline R.; Liu, Xiong; Chance, Kelly; Abad, Gonzalo Gonzalez; Liu, Cheng; Zoogman, Peter] Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA. [Leitch, JamesW.; Cole, Joshua; Delker, Thomas; Good, William; Murcray, Frank; Ruppert, Lyle; Soo, Daniel] Ball Aerosp & Technol Corp, Boulder, CO 80301 USA. [Follette-Cook, Melanie B.] Morgan State Univ, GESTAR, Baltimore, MD 21251 USA. [Follette-Cook, Melanie B.; Janz, Scott J.; Kowalewski, Matthew G.; Loughner, Christopher P.; Pickering, Kenneth E.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Loughner, Christopher P.; Kelley, Paul; Ren, Xinrong] Univ Maryland, College Pk, MD 20742 USA. [Herman, Jay R.] Univ Maryland Baltimore Cty, Baltimore, MD 21201 USA. [Beaver, Melinda R.; Long, Russell W.; Szykman, James J.] US EPA, Res Triangle Pk, NC 27711 USA. [Judd, Laura M.] Univ Houston, Houston, TX 77004 USA. [Kelley, Paul; Luke, Winston T.; Ren, Xinrong] NOAA, Air Resources Lab, College Pk, MD 20740 USA. [Al-Saadi, Jassim A.] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Liu, Cheng] Univ Sci & Technol, Hefei, Anhui, Peoples R China. RP Nowlan, CR (reprint author), Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA. EM cnowlan@cfa.harvard.edu RI Liu, Xiong/P-7186-2014; Ren, Xinrong/E-7838-2015; Pickering, Kenneth/E-6274-2012; OI Liu, Xiong/0000-0003-2939-574X; Ren, Xinrong/0000-0001-9974-1666; Gonzalez Abad, Gonzalo/0000-0002-8090-6480; Loughner, Christopher/0000-0002-3833-2014 FU NASA Earth Science Technology Office (ESTO) Instrument Incubator Program; NASA GEO-CAPE Program FX This work was supported under the NASA Earth Science Technology Office (ESTO) Instrument Incubator Program and the NASA GEO-CAPE Program. MODIS MCD43GF V005 data were provided by the MODIS remote sensing group at the University of Massachusetts, Boston. We acknowledge the free use of tropospheric NO2 column data from GOME-2/Metop-A from http://www.temis.nl. The US Environmental Protection Agency through its Office of Research and Development under the Air, Climate and Energy Research Program collaborated on this research. It has been subjected to agency review and approved for publication. NR 63 TC 3 Z9 3 U1 5 U2 6 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1867-1381 EI 1867-8548 J9 ATMOS MEAS TECH JI Atmos. Meas. Tech. PY 2016 VL 9 IS 6 BP 2647 EP 2668 DI 10.5194/amt-9-2647-2016 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DQ7OM UT WOS:000379397100013 ER PT J AU Shalamzari, MS Vermeylen, R Blockhuys, F Kleindienst, TE Lewandowski, M Szmigielski, R Rudzinski, KJ Spolnik, G Danikiewicz, W Maenhaut, W Claeys, M AF Shalamzari, Mohammad Safi Vermeylen, Reinhilde Blockhuys, Frank Kleindienst, Tadeusz E. Lewandowski, Michael Szmigielski, Rafal Rudzinski, Krzysztof J. Spolnik, Grzegorz Danikiewicz, Witold Maenhaut, Willy Claeys, Magda TI Characterization of polar organosulfates in secondary organic aerosol from the unsaturated aldehydes 2-E-pentenal, 2-E-hexenal, and 3-Z-hexenal SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID GREEN LEAF VOLATILES; ATMOSPHERIC AEROSOLS; AMBIENT AEROSOL; ISOPRENE; OXIDATION; MASS; PHOTOOXIDATION; CHEMISTRY; KINETICS; IDENTIFICATION AB We show in the present study that the unsaturated aldehydes 2-E-pentenal, 2-E-hexenal, and 3-Z-hexenal are biogenic volatile organic compound (BVOC) precursors for polar organosulfates with molecular weights (MWs) 230 and 214, which are also present in ambient fine aerosol from a forested site, i.e., K-puszta, Hungary. These results complement those obtained in a previous study showing that the green leaf aldehyde 3-Z-hexenal serves as a precursor for MW 226 organosulfates. Thus, in addition to isoprene, the green leaf volatiles (GLVs) 2-E-hexenal and 3-Z-hexenal, emitted due to plant stress (mechanical wounding or insect attack), and 2-E-pentenal, a photolysis product of 3-Z-hexenal, should be taken into account for secondary organic aerosol and organosulfate formation. Polar organosulfates are of climatic relevance because of their hydrophilic properties and cloud effects. Extensive use was made of organic mass spectrometry (MS) and detailed interpretation of MS data (i.e., ion trap MS and accurate mass measurements) to elucidate the chemical structures of the MW 230, 214 and 170 organosulfates formed from 2-E-pentenal and indirectly from 2-E-hexenal and 3-Z-hexenal. In addition, quantum chemical calculations were performed to explain the different mass spectral behavior of 2,3-dihydroxypentanoic acid sulfate derivatives, where only the isomer with the sulfate group at C-3 results in the loss of SO3. The MW 214 organosulfates formed from 2-E-pentenal are explained by epoxidation of the double bond in the gas phase and sulfation of the epoxy group with sulfuric acid in the particle phase through the same pathway as that proposed for 3-sulfooxy-2-hydroxy-2-methylpropanoic acid from the isoprene-related alpha,beta-unsaturated aldehyde methacrolein in previous work (Lin et al., 2013). The MW 230 organosulfates formed from 2-E-pentenal are tentatively explained by a novel pathway, which bears features of the latter pathway but introduces an additional hydroxyl group at the C-4 position. Evidence is also presented that the MW 214 positional isomer, 2-sulfooxy-3-hydroxypentanoic acid, is unstable and decarboxylates, giving rise to 1-sulfooxy-2-hydroxybutane, a MW 170 organosulfate. Furthermore, evidence is obtained that lactic acid sulfate is generated from 2-E-pentenal. This chemistry could be important on a regional and local scale where GLV emissions such as from grasses and cereal crops are substantial. C1 [Shalamzari, Mohammad Safi; Vermeylen, Reinhilde; Maenhaut, Willy; Claeys, Magda] Univ Antwerp, Dept Pharmaceut Sci, B-2610 Antwerp, Belgium. [Shalamzari, Mohammad Safi; Maenhaut, Willy] Univ Ghent, Dept Analyt Chem, B-9000 Ghent, Belgium. [Blockhuys, Frank] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium. [Kleindienst, Tadeusz E.; Lewandowski, Michael] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Szmigielski, Rafal; Rudzinski, Krzysztof J.] Polish Acad Sci, Inst Phys Chem, PL-01224 Warsaw, Poland. [Spolnik, Grzegorz; Danikiewicz, Witold] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland. RP Claeys, M (reprint author), Univ Antwerp, Dept Pharmaceut Sci, B-2610 Antwerp, Belgium. EM magda.claeys@uantwerpen.be RI Maenhaut, Willy/M-3091-2013; Danikiewicz, Witold/H-2257-2016 OI Maenhaut, Willy/0000-0002-4715-4627; Danikiewicz, Witold/0000-0003-0484-2689 FU Belgian Federal Science Policy Office through network project "Biogenic Influences on Oxidants and Secondary Organic Aerosol: theoretical, laboratory and modelling investigations (BIOSOA)"; Research Foundation Flanders (FWO) through project "Secondary Organic Aerosol formation from monoterpenes: GAPS in our current understanding (SOAGAPS)"; PAS; FWO - Flanders; US Environmental Protection Agency through Office of Research and Development [EP-D-10-070] FX Research at the University of Antwerp was supported by the Belgian Federal Science Policy Office through the network project "Biogenic Influences on Oxidants and Secondary Organic Aerosol: theoretical, laboratory and modelling investigations (BIOSOA)" and by the Research Foundation Flanders (FWO) through the project "Secondary Organic Aerosol formation from monoterpenes: GAPS in our current understanding (SOAGAPS)". The Polish Academy of Sciences (PAS) collaborated in the study reported here through an academic exchange project supported by the PAS and FWO - Flanders. The US Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under contract EP-D-10-070 to Alion Science and Technology. The manuscript has been subjected to agency review and has been cleared for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use. NR 53 TC 5 Z9 5 U1 16 U2 21 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PY 2016 VL 16 IS 11 BP 7135 EP 7148 DI 10.5194/acp-16-7135-2016 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DP2WQ UT WOS:000378354600029 ER PT J AU Al-Abed, SR Virkutyte, J Ortenzio, JNR McCarrick, RM Degn, LL Zucker, R Coates, NH Childs, K Ma, HB Diamond, S Dreher, K Boyes, WK AF Al-Abed, Souhail R. Virkutyte, Jurate Ortenzio, Jayna N. R. McCarrick, Robert M. Degn, Laura L. Zucker, Robert Coates, Najwa Haykal Childs, Kristin Ma, Hongbo Diamond, Steve Dreher, Kevin Boyes, William K. TI Environmental aging alters Al(OH)(3) coating of TiO2 nanoparticles enhancing their photocatalytic and phototoxic activities SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID TITANIUM-DIOXIDE NANOPARTICLES; FLOW-CYTOMETRY; VISIBLE-LIGHT; SWIMMING POOL; UV FILTERS; SUNSCREENS; SURFACE; WATER; KERATINOCYTES; NANOMATERIAL AB As a component of sunscreen formulations, TiO2 engineered nanomaterials (ENM) are coated to prevent reactive oxygen species from causing damage to skin. We investigated the stability of an Al(OH)(3) coating by exposing 25 nm Al(OH)(3)center dot TiO2 ENM to simulated swimming pool water (SPW) for 45 minutes, 1, 3, 10, or 14 days. Electron microscopy and spectroscopy indicated that exposure to SPW caused a redistribution of the Al(OH)(3) coating allowing photocatalytic formation of hydroxyl radicals. Aged ENM showed significantly greater phototoxicity under UVA irradiation than un-aged ENM in a human-derived retinal pigment epithelium cell line (ARPE-19). Photocatalytic activity and phototoxicity of aged Al(OH)(3)center dot TiO2 was significantly less than that of the positive control-uncoated P25 TiO2. In summary, the aging of Al(OH)(3)center dot TiO2 ENM in SPW redistributed the coating and reduced its protective properties, thereby increasing reactivity and potential phototoxicity. C1 [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Virkutyte, Jurate] Keramida Inc, 5011 Kenwood Rd, Cincinnati, OH 45227 USA. [Ortenzio, Jayna N. R.; Degn, Laura L.; Zucker, Robert; Coates, Najwa Haykal; Dreher, Kevin; Boyes, William K.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [McCarrick, Robert M.] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA. [Childs, Kristin] Duke Univ Hlth Syst, Ctr Human Dis Modeling, Durham, NC 27701 USA. [Ma, Hongbo] Univ Wisconsin, Zilber Sch Publ Hlth, Environm Hlth Sci, Lapham Hall 442, Milwaukee, WI 53211 USA. [Diamond, Steve] NanoSafe Inc, Duluth, MN 55811 USA. RP Boyes, WK (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. FU National Risk Management Research Laboratory; National Health and Environmental Effects Research Laboratory, of U.S. Environmental Protection Agency (EPA) under the EPA's Chemical Safety for Sustainability Research Program; U.S. Department of Energy; EPA FX This research was funded by and conducted at the National Risk Management Research Laboratory and the National Health and Environmental Effects Research Laboratory, of U.S. Environmental Protection Agency (EPA) under the EPA's Chemical Safety for Sustainability Research Program. Additionally, this research was supported in part by an appointment to the Research Participation Program for the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. This paper was subjected to the internal policy review of the U.S. EPA and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The authors wish to thank Dr. Gary Logan of Miami University (Oxford, OH) for the use of his facility for analyzing radical formation and for his insightful comments. The authors also thank John Havel for his work on the graphical abstract and Dr. Tim Shafer and Dr. Kim Rogers for review comments on an earlier version of the manuscript. NR 41 TC 1 Z9 1 U1 14 U2 19 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON SCI-NANO JI Environ.-Sci. Nano PY 2016 VL 3 IS 3 BP 593 EP 601 DI 10.1039/c5en00250h PG 9 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA DP1IZ UT WOS:000378245000009 ER PT J AU Neil, CW Ray, JR Lee, B Jun, YS AF Neil, Chelsea W. Ray, Jessica R. Lee, Byeongdu Jun, Young-Shin TI Fractal aggregation and disaggregation of newly formed iron(III) (hydr)oxide nanoparticles in the presence of natural organic matter and arsenic SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID IRON-OXIDE NANOPARTICLES; MANAGED AQUIFER RECHARGE; HUMIC-ACID; ADSORPTION; SORPTION; WATER; SEDIMENTS; MOBILIZATION; ENVIRONMENT; NUCLEATION AB Water chemistry affects the nucleation kinetics, precipitate morphology, and quantity of iron(III) (hydr)oxide nanoparticles, directly impacting the reactive surface area of geomedia and fate of associated waterborne contaminants. In this study, we utilized in situ grazing-incidence small angle X-ray scattering (GISAXS) and complementary ex situ techniques to investigate heterogeneous iron(III) (hydr)oxide nucleation on quartz in the presence of natural organic matter (NOM) and arsenate. Results indicate unique fractal aggregation behavior in the systems containing NOM and precipitating iron(III) (hydr)oxide nanoparticles. Furthermore, the coexistence of arsenic and NOM lead to the formation of two distinct particle size ranges: larger particles dominated by arsenic effects, and smaller particles dominated by NOM effects. These new findings provide important implications for understanding the nucleation, growth, and aggregation of iron(III) (hydr)oxides in aqueous systems where NOM is present, such as natural surface waters and water and wastewater treatment plants. This study also offers new insight into how NOM-associated iron(III) (hydr)oxides can interact with aqueous contaminants such as arsenate. C1 [Neil, Chelsea W.; Ray, Jessica R.; Jun, Young-Shin] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Lee, Byeongdu] Argonne Natl Lab, Xray Sci Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Neil, Chelsea W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Ray, Jessica R.] Univ Calif Berkeley, Civil & Environm Engn, Berkeley, CA 94720 USA. RP Jun, YS (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. EM ysjun@wustl.edu OI Lee, Byeongdu/0000-0003-2514-8805 FU National Science Foundation [EAR-1424927, CHE-1214090]; Mr. and Mrs. Spencer T. Olin Fellowship; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] FX We are grateful for support received from the National Science Foundation (EAR-1424927 and CHE-1214090). CWN acknowledges the generous support of the Mr. and Mrs. Spencer T. Olin Fellowship. We wish to thank the Environmental NanoChemistry Group members for valuable discussion. Use of the Advanced Photon Source (Sector 11-BM for HRXRD and Sector 12 ID-B for GISAXS) at the Argonne National Laboratory was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract no. DE-AC02-06CH11357. NR 52 TC 1 Z9 1 U1 10 U2 14 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON SCI-NANO JI Environ.-Sci. Nano PY 2016 VL 3 IS 3 BP 647 EP 656 DI 10.1039/c5en00283d PG 10 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA DP1IZ UT WOS:000378245000015 ER PT J AU Gordon, CJ Jarema, K Johnstone, AFM Phillips, PM AF Gordon, C. J. Jarema, K. Johnstone, A. F. M. Phillips, P. M. TI Effect of genetic strain and gender on age-related changes in body composition of the laboratory rat SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID BROWN-NORWAY RATS; ABSORPTIOMETRY; VALIDATION; VOLUME; OZONE; FAT AB Body fat serves as a storage compartment for lipophilic pollutants and affects the pharmacokinetics of many toxic chemicals. Understanding how body fat varies with gender, strain, and age may be essential for development of experimental models to study mechanisms of toxicity. Nuclear magnetic resonance (NMR)-based analysis serves as a noninvasive means of assessing proportions of fat, lean, and fluid in rodents over their lifetime. The aim of this study was to track changes in body composition of male and female Long-Evans (LE), Sprague-Dawley (SD), Fischer (F334), and Brown Norway (BN) rats from postweaning over a >2-yr period. Percent fat of preweaned LE and SD rats was markedly higher compared to the other strains. LE and SD strains displayed marked increases in body fat from weaning to 8 mo of age. Postweaned F344 male and females showed relatively low levels of percent fat; however, at 2 yr of age percent fat of females was equal to that of SD and LE in females. BN rats showed the highest levels of lean tissue and lowest levels of fat. Percent fat of the BN strain rose at the slowest rate as they aged. Percent fluid was consistently higher in males for all strains. Females tended to have higher percent fat than males in LE, SD, and F344 strains. Assessing changes in body fat as well as lean and fluid of various strains of male and female rats over their lifetime may prove useful in many research endeavors, including pharmacokinetics of lipophilic toxicants, mechanisms underlying obesity, and metabolic disorders. C1 [Gordon, C. J.; Jarema, K.; Johnstone, A. F. M.; Phillips, P. M.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Gordon, CJ (reprint author), US EPA, B105-04, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov NR 17 TC 1 Z9 1 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2016 VL 79 IS 8 BP 376 EP 392 DI 10.1080/15287394.2016.1169237 PG 17 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DO9PE UT WOS:000378118000005 PM 27267702 ER PT J AU Carriger, JF Barron, MG AF Carriger, John F. Barron, Mace G. TI A Practical Probabilistic Graphical Modeling Tool for Weighing Ecological Risk-Based Evidence SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE Bayesian belief networks; ecological risk assessment; probabilistic graphical models; sediment quality criteria; sediment quality triad; weight-of-evidence ID SEDIMENT QUALITY TRIAD; CONTAMINATION; FRAMEWORK AB Past weight-of-evidence frameworks for adverse ecological effects have provided soft-scoring procedures for judgments based on the quality and measured attributes of evidence. Here, we provide a flexible probabilistic structure for weighing and integrating lines of evidence for ecological risk determinations. Probabilistic approaches can provide both a quantitative weighing of lines of evidence and methods for evaluating risk and uncertainty. The current modeling structure was developed for propagating uncertainties in measured endpoints and their influence on the plausibility of adverse effects. To illustrate the approach, we apply the model framework to the sediment quality triad using example lines of evidence for sediment chemistry measurements, bioassay results, and in situ infauna diversity of benthic communities using a simplified hypothetical case study. We then combine the three lines evidence and evaluate sensitivity to the input parameters, and show how uncertainties are propagated and how additional information can be incorporated to rapidly update the probability of impacts. The developed network model can be expanded to accommodate additional lines of evidence, variables and states of importance, and different types of uncertainties in the lines of evidence including spatial and temporal as well as measurement errors. C1 [Carriger, John F.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, ORISE,Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Barron, Mace G.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. RP Barron, MG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM barron.mace@epa.gov FU U.S. Environmental Protection Agency (EPA); U.S. Department of Energy FX We thank Glenn Suter and Susan Cormier for helpful comments on an earlier draft of this manuscript. This research was supported in part by an appointment to the Oak Ridge Institute for Science and Education participant research program supported by an interagency agreement between the U.S. Environmental Protection Agency (EPA) and the U.S. Department of Energy. This paper has been reviewed according to EPA guidelines, but does not necessarily represent the views of the Agency. NR 20 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1532-0383 EI 1549-7887 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PY 2016 VL 25 IS 4 BP 476 EP 487 DI 10.1080/15320383.2016.1171293 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DO4MK UT WOS:000377756900009 ER PT J AU Irby, ID Friedrichs, MAM Friedrichs, CT Bever, AJ Hood, RR Lanerolle, LWJ Li, M Linker, L Scully, ME Sellner, K Shen, J Testa, J Wang, H Wang, P Xia, M AF Irby, Isaac D. Friedrichs, Marjorie A. M. Friedrichs, Carl T. Bever, Aaron J. Hood, Raleigh R. Lanerolle, Lyon W. J. Li, Ming Linker, Lewis Scully, Malcolm E. Sellner, Kevin Shen, Jian Testa, Jeremy Wang, Hao Wang, Ping Xia, Meng TI Challenges associated with modeling low-oxygen waters in Chesapeake Bay: a multiple model comparison SO BIOGEOSCIENCES LA English DT Article ID EASTERN NORTH-AMERICA; ECOSYSTEM MODELS; EUTROPHICATION MODEL; BIOGEOCHEMICAL MODEL; PHYSICAL CONTROLS; DATA ASSIMILATION; DISSOLVED-OXYGEN; SKILL ASSESSMENT; ATLANTIC-OCEAN; FOOD-WEB AB As three-dimensional (3-D) aquatic ecosystem models are used more frequently for operational water quality forecasts and ecological management decisions, it is important to understand the relative strengths and limitations of existing 3-D models of varying spatial resolution and biogeochemical complexity. To this end, 2-year simulations of the Chesapeake Bay from eight hydrodynamic-oxygen models have been statistically compared to each other and to historical monitoring data. Results show that although models have difficulty resolving the variables typically thought to be the main drivers of dissolved oxygen variability (stratification, nutrients, and chlorophyll), all eight models have significant skill in reproducing the mean and seasonal variability of dissolved oxygen. In addition, models with constant net respiration rates independent of nutrient supply and temperature reproduced observed dissolved oxygen concentrations about as well as much more complex, nutrient-dependent biogeochemical models. This finding has significant ramifications for short-term hypoxia forecasts in the Chesapeake Bay, which may be possible with very simple oxygen parameterizations, in contrast to the more complex full biogeochemical models required for scenario-based forecasting. However, models have difficulty simulating correct density and oxygen mixed layer depths, which are important ecologically in terms of habitat compression. Observations indicate a much stronger correlation between the depths of the top of the pycnocline and oxycline than between their maximum vertical gradients, highlighting the importance of the mixing depth in defining the region of aerobic habitat in the Chesapeake Bay when low-oxygen bottom waters are present. Improvement in hypoxia simulations will thus depend more on the ability of models to reproduce the correct mean and variability of the depth of the physically driven surface mixed layer than the precise magnitude of the vertical density gradient. C1 [Irby, Isaac D.; Friedrichs, Marjorie A. M.; Friedrichs, Carl T.; Shen, Jian] Coll William & Mary, Virginia Inst Marine Sci, POB 1346, Gloucester Point, VA 23062 USA. [Bever, Aaron J.] Anchor QEA LLC, 130 Battery St,Suite 400, San Francisco, CA 94111 USA. [Hood, Raleigh R.; Wang, Hao] Univ Maryland, Ctr Environm Sci, Horn Point Lab, POB 775, Cambridge, MD 21613 USA. [Lanerolle, Lyon W. J.] NOAA, NOS, OCS, Coast Survey Dev Lab, 1315 East West Highway, Silver Spring, MD 20910 USA. [Lanerolle, Lyon W. J.] ERT Inc, 14401 Sweitzer Lane Suite 300, Laurel, MD 20707 USA. [Li, Ming; Testa, Jeremy] Univ Maryland, Ctr Environm Sci, Chesapeake Biol Lab, POB 38, Solomons, MD 20688 USA. [Linker, Lewis] US EPA, Chesapeake Bay Program Off, 410 Severn Ave, Annapolis, MD 21403 USA. [Scully, Malcolm E.] Woods Hole Oceanog Inst, Appl Ocean Phys & Engn Dept, Woods Hole, MA 02543 USA. [Sellner, Kevin] Chesapeake Res Consortium, 645 Contees Wharf Rd, Edgewater, MD 21037 USA. [Wang, Ping] VIMS Chesapeake Bay Program Off, 410 Severn Ave, Annapolis, MD 21403 USA. [Xia, Meng] Univ Maryland Eastern Shore, Dept Nat Sci, College Pk, MD USA. RP Irby, ID; Friedrichs, MAM (reprint author), Coll William & Mary, Virginia Inst Marine Sci, POB 1346, Gloucester Point, VA 23062 USA. EM iirby@vims.edu; marjy@vims.edu RI Li, Ming/B-3485-2015; OI Li, Ming/0000-0003-1492-4127; Bever, Aaron/0000-0002-2196-0831; Friedrichs, Marjorie/0000-0003-2828-7595; Friedrichs, Carl/0000-0002-1810-900X FU NOAA IOOS program FX This work was supported by the NOAA IOOS program as part of the Coastal Ocean Modeling Testbed. We thank Yun Li and Younjoo Lee for help with the ROMS-RCA simulations used in this analysis and Ray Najjar for his insights and comments. This is VIMS contribution 3520 and UMCES contribution 5130. NR 80 TC 3 Z9 4 U1 3 U2 10 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1726-4170 EI 1726-4189 J9 BIOGEOSCIENCES JI Biogeosciences PY 2016 VL 13 IS 7 BP 2011 EP 2028 DI 10.5194/bg-13-2011-2016 PG 18 WC Ecology; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA DN7RW UT WOS:000377276000003 ER PT J AU Rattanavaraha, W Chu, K Budisulistiorini, H Riva, M Lin, YH Edgerton, ES Baumann, K Shaw, SL Guo, HY King, L Weber, RJ Neff, ME Stone, EA Offenberg, JH Zhang, ZF Gold, A Surratt, JD AF Rattanavaraha, Weruka Chu, Kevin Budisulistiorini, Hapsari Riva, Matthieu Lin, Ying-Hsuan Edgerton, Eric S. Baumann, Karsten Shaw, Stephanie L. Guo, Hongyu King, Laura Weber, Rodney J. Neff, Miranda E. Stone, Elizabeth A. Offenberg, John H. Zhang, Zhenfa Gold, Avram Surratt, Jason D. TI Assessing the impact of anthropogenic pollution on isoprene-derived secondary organic aerosol formation in PM2.5 collected from the Birmingham, Alabama, ground site during the 2013 Southern Oxidant and Aerosol Study SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID SOUTHEASTERN UNITED-STATES; MASS-SPECTROMETRY; REACTIVE UPTAKE; ATMOSPHERIC AEROSOLS; OXIDATION-PRODUCTS; AMBIENT AEROSOL; TECHNICAL NOTE; SOA FORMATION; PHOTOOXIDATION; EPOXYDIOLS AB In the southeastern US, substantial emissions of isoprene from deciduous trees undergo atmospheric oxidation to form secondary organic aerosol (SOA) that contributes to fine particulate matter (PM2.5). Laboratory studies have revealed that anthropogenic pollutants, such as sulfur dioxide (SO2), oxides of nitrogen (NOx), and aerosol acidity, can enhance SOA formation from the hydroxyl radical (OH)-initiated oxidation of isoprene; however, the mechanisms by which specific pollutants enhance isoprene SOA in ambient PM2.5 remain unclear. As one aspect of an investigation to examine how anthropogenic pollutants influence isoprene-derived SOA formation, high-volume PM2.5 filter samples were collected at the Birmingham, Alabama (BHM), ground site during the 2013 Southern Oxidant and Aerosol Study (SOAS). Sample extracts were analyzed by gas chromatography-electron ionization-mass spectrometry (GC/EI-MS) with prior trimethylsilylation and ultra performance liquid chromatography coupled to electrospray ionization high-resolution quadrupole time-of-flight mass spectrometry (UPLC/ESI-HR-QTOFMS) to identify known isoprene SOA tracers. Tracers quantified using both surrogate and authentic standards were compared with collocated gas- and particle-phase data as well as meteorological data provided by the Southeastern Aerosol Research and Characterization (SEARCH) network to assess the impact of anthropogenic pollution on isoprene-derived SOA formation. Results of this study reveal that isoprene-derived SOA tracers contribute a substantial mass fraction of organic matter (OM) ( aEuro-7 to aEuro-20aEuro-%). Isoprene-derived SOA tracers correlated with sulfate (SO42-) (r(2) = 0.34, n = 117) but not with NOx. Moderate correlations between methacrylic acid epoxide and hydroxymethyl-methyl-alpha-lactone (together abbreviated MAE/HMML)-derived SOA tracers with nitrate radical production (P[NO3]) (r(2) = 0.57, n = 40) were observed during nighttime, suggesting a potential role of the NO3 radical in forming this SOA type. However, the nighttime correlation of these tracers with nitrogen dioxide (NO2) (r(2) = 0.26, n = 40) was weaker. Ozone (O-3) correlated strongly with MAE/HMML-derived tracers (r(2) = 0.72, n = 30) and moderately with 2-methyltetrols (r(2) = 0.34, n = 15) during daytime only, suggesting that a fraction of SOA formation could occur from isoprene ozonolysis in urban areas. No correlation was observed between aerosol pH and isoprene-derived SOA. Lack of correlation between aerosol acidity and isoprene-derived SOA is consistent with the observation that acidity is not a limiting factor for isoprene SOA formation at the BHM site as aerosols were acidic enough to promote multiphase chemistry of isoprene-derived epoxides throughout the duration of the study. All in all, these results confirm previous studies suggesting that anthropogenic pollutants enhance isoprene-derived SOA formation. C1 [Rattanavaraha, Weruka; Chu, Kevin; Budisulistiorini, Hapsari; Riva, Matthieu; Lin, Ying-Hsuan; Zhang, Zhenfa; Gold, Avram; Surratt, Jason D.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Edgerton, Eric S.; Baumann, Karsten] Atmospher Res & Anal Inc, Cary, NC USA. [Shaw, Stephanie L.] Elect Power Res Inst, Palo Alto, CA USA. [Guo, Hongyu; King, Laura; Weber, Rodney J.] Georgia Inst Technol, Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Neff, Miranda E.; Stone, Elizabeth A.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. [Offenberg, John H.] US EPA, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA. [Budisulistiorini, Hapsari] Nanyang Technol Univ, Earth Observ Singapore, Singapore 639798, Singapore. [Lin, Ying-Hsuan] Univ Michigan, Dept Chem, Michigan Soc Fellows, Ann Arbor, MI 48109 USA. RP Surratt, JD (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. EM surratt@unc.edu RI Offenberg, John/C-3787-2009; Riva, Matthieu/R-6852-2016; OI Offenberg, John/0000-0002-0213-4024; Riva, Matthieu/0000-0003-0054-4131; Lin, Ying-Hsuan/0000-0001-8904-1287 FU US Environmental Protection Agency (EPA) [835404]; Electric Power Research Institute (EPRI); National Oceanic and Atmospheric Administration (NOAA) Climate Program Office's AC4 program [NA130AR4310064]; Camille and Henry Dreyfus Postdoctoral Fellowship Program in Environmental Chemistry; National Institute for Environmental Health Sciences (NIEHS) [5P20-ES10126]; EPA STAR grant [8354101] FX This work was funded by the US Environmental Protection Agency (EPA) through grant number 835404. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the US EPA. Further, the US EPA does not endorse the purchase of any commercial products or services mentioned in the publication. The authors would also like to thank the Electric Power Research Institute (EPRI) for their support. This study was supported in part by the National Oceanic and Atmospheric Administration (NOAA) Climate Program Office's AC4 program, award number NA130AR4310064. The authors thank the Camille and Henry Dreyfus Postdoctoral Fellowship Program in Environmental Chemistry for their financial support. The authors thank Louisa Emmons and Christoph Knote for their assistance with chemical forecasts made available during the SOAS campaign. We would like to thank Annmarie Carlton, Joost deGouw, Jose Jimenez, and Allen Goldstein for helping to organize the SOAS campaign and coordinating communication between ground sites. UPLC/ESI-HR-Q-TOFMS analyses were conducted in the UNC-CH Biomarker Mass Facility located within the Department of Environmental Sciences and Engineering, which is a part of the UNC-CH Center for Environmental Health and Susceptibility supported by the National Institute for Environmental Health Sciences (NIEHS), grant number 5P20-ES10126. WSOC measurements at the University of Iowa were supported through EPA STAR grant 8354101. The authors thank Theran Riedel for useful discussions. We also thank SCG Chemicals Co., Ltd., Siam Cement Group, Thailand, for the full support for W. Rattanavaraha attending UNC, Chapel Hill. NR 69 TC 10 Z9 10 U1 21 U2 37 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PY 2016 VL 16 IS 8 BP 4897 EP 4914 DI 10.5194/acp-16-4897-2016 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DN3BK UT WOS:000376937000010 ER PT B AU Willison, SA Magnuson, ML Hanley, AS Nehrkorn, DW AF Willison, Stuart A. Magnuson, Matthew L. Hanley, Adrian S. Nehrkorn, David W. BE Badiru, AB Racz, L TI Measurement of environmental contamination SO HANDBOOK OF MEASUREMENTS: BENCHMARKS FOR SYSTEMS ACCURACY AND PRECISION SE Industrial Innovation Series LA English DT Article; Book Chapter ID TANDEM MASS-SPECTROMETRY; INTER-LABORATORY TRANSFERABILITY; SOLID-PHASE EXTRACTION; FULL REFERENCE LIBRARY; FORENSIC TOXICOLOGY; PESTICIDE-RESIDUES; SPECTRAL LIBRARY; LC-MS/MS; WATER; IDENTIFICATION C1 [Willison, Stuart A.; Magnuson, Matthew L.] US EPA, Washington, DC 20460 USA. [Hanley, Adrian S.] US EPA, Off Water, Washington, DC 20460 USA. RP Willison, SA (reprint author), US EPA, Washington, DC 20460 USA. NR 50 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-2523-5; 978-1-4822-2522-8 J9 IND INNOV SER PY 2016 VL 37 BP 93 EP 115 PG 23 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA BE7NG UT WOS:000375598500005 ER PT J AU Gordon, CJ Phillips, PM Beasley, TE Ledbetter, A Aydin, C Snow, SJ Kodavanti, UP Johnstone, AF AF Gordon, Christopher J. Phillips, Pamela M. Beasley, Tracey E. Ledbetter, A. Aydin, Cenk Snow, Samantha J. Kodavanti, Urmila P. Johnstone, Andrew F. TI Pulmonary sensitivity to ozone exposure in sedentary versus chronically trained, female rats SO INHALATION TOXICOLOGY LA English DT Article DE Air pollution; body composition; exercise; fat loss; obesity ID INNATE AIRWAY HYPERRESPONSIVENESS; BROWN-NORWAY RATS; LUNG INFLAMMATION; AEROBIC EXERCISE; CIGARETTE-SMOKE; OBESITY; POLLUTION; MICE AB Epidemiological data suggest that a sedentary lifestyle may contribute to increased susceptibility for some environmental toxicants. We developed an animal model of active versus sedentary life style by providing female Sprague-Dawley rats with continuous access to running wheels. Sedentary rats were housed in standard cages without wheels. After training for 12 wks, rats were exposed to 0, 0.25, 0.5 or 1.0ppm ozone [O-3 for 5 h/d, 1 d/wk, for 6 wk (N = 10 per group)]. Body composition (%fat, lean and fluid) was monitored noninvasively over the course of the study. Ventilatory parameters [tidal volume, minute ventilation, frequency and enhanced pause (Penh)] were assessed using whole-body plethysmography prior to O-3 and 24 h after the 5th O-3 exposure. Trained rats lost similar to 2% body fat after 12 wk of access to running wheels. Peak wheel activity was reduced by 40% after exposure to 1.0ppm O-3. After the 5th O-3 exposure, body weight and % fat were reduced in sedentary but not trained rats. Penh was significantly elevated in sedentary but not trained rats the day after exposure to 1.0 ppm O-3. However, lung lavage cell counts and biomarkers of pulmonary inflammation measured 1 day after the final exposure were inconsistently affected by training. Wheel running led to marked physiological responses along with some indication of improved pulmonary recovery from O-3 exposure. However, wheel running with O-3 exposure may also be a detriment for some pulmonary endpoints. Overall, a sedentary lifestyle may increase susceptibility to O-3, but additional studies are needed. C1 [Gordon, Christopher J.; Phillips, Pamela M.; Beasley, Tracey E.; Johnstone, Andrew F.] US EPA, Tox Assessment Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Ledbetter, A.; Snow, Samantha J.; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Aydin, Cenk] Uludag Univ, Fac Vet Med, Dept Physiol, Bursa, Turkey. RP Gordon, CJ (reprint author), US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov OI Snow, Samantha/0000-0003-1812-8582 NR 25 TC 1 Z9 1 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2016 VL 28 IS 7 BP 293 EP 302 DI 10.3109/08958378.2016.1163441 PG 10 WC Toxicology SC Toxicology GA DN4LX UT WOS:000377039600001 PM 27160658 ER PT J AU Kim, JH Harvey, LA Evans, AL Byfield, GE Betancourt, DA Dean, TR AF Kim, J. H. Harvey, L. A. Evans, A. L. Byfield, G. E. Betancourt, D. A. Dean, T. R. TI Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types SO INHALATION TOXICOLOGY LA English DT Article DE Cytotoxicity; inflammation; mycotoxin; Raw cells; Stachybotrys chartarum; wallboard ID TRICHOTHECENE MYCOTOXINS; PULMONARY HEMORRHAGE; TOXIGENIC FUNGI; HEALTH; HEMOSIDEROSIS; TOXICITY; CHILD; ASSAY; LUNG AB The many benefits of building "green" have motivated the use of sustainable products in the design and execution of the built environment. However, the use of these natural or recycled materials, some of which have been treated with antimicrobials, provides a growth opportunity for microorganisms with the potential to elicit adverse health effects especially in the presence of an antimicrobial. The focus of this research was to determine the effects of Stachybotrys chartarum (strains Houston and 51-11) grown under different conditions on a macrophage cell line (Raw 264.7) using endpoints, including cytotoxicity, and those associated with immunity specifically inflammation and MHC class II expression. The fungi were grown on four different gypsum products, and macrophages were exposed to whole spores of both strains and fragmented spores of strain 51-11. Whole spores of the Houston strain elicited no cytotoxicity with some level of inflammation, while exposure to whole spores of 51-11 caused variable responses depending on the wallboard type supporting the fungal growth. High concentrations of fragmented 51-11 spores primarily resulted in the apoptosis of macrophage with no inflammation. None of the fungal strains caused elevated levels of major histocompatibility complex (MHC) class II expression on the surface of Raw cells. Mycotoxin levels of 51-11 spores from all of the wallboard types measured >250 ng/mu L of T2 equivalent toxin based on activity. Collectively, the data demonstrated that all of the wallboard types supported growth of fungi with the ability to elicit harmful biological responses with the potential to negatively impact human health. C1 [Kim, J. H.; Harvey, L. A.; Evans, A. L.; Byfield, G. E.] RTI Int, Microbiol, Durham, NC USA. [Byfield, G. E.] St Augustines Univ, Biol & Phys Sci, Raleigh, NC USA. [Betancourt, D. A.; Dean, T. R.] US EPA, Natl Risk Management Res Lab, Air Pollut Prevent Control Div, Res Triangle Pk, NC 27711 USA. RP Kim, JH (reprint author), RTI Int, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM jeankim@rti.org FU EPA [EP-C-11-036] FX This work was funded under EPA Agreement No. EP-C-11-036. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 23 TC 0 Z9 0 U1 3 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2016 VL 28 IS 7 BP 303 EP 312 DI 10.3109/08958378.2016.1170909 PG 10 WC Toxicology SC Toxicology GA DN4LX UT WOS:000377039600002 PM 27097835 ER PT J AU Snow, SJ Gordon, CJ Bass, VL Schladweiler, MC Ledbetter, AD Jarema, KA Phillips, PM Johnstone, AF Kodavanti, UP AF Snow, Samantha J. Gordon, Christopher J. Bass, Virginia L. Schladweiler, Mette C. Ledbetter, Allen D. Jarema, Kimberly A. Phillips, Pamela M. Johnstone, Andrew F. Kodavanti, Urmila P. TI Age-related differences in pulmonary effects of acute and subchronic episodic ozone exposures in Brown Norway rats SO INHALATION TOXICOLOGY LA English DT Article DE Adaptation; age-related susceptibility; ozone; pulmonary; whole-body plethysmography ID AIR-POLLUTION; BAROMETRIC PLETHYSMOGRAPHY; NONINVASIVE MEASUREMENT; INHALED OZONE; RISK-FACTORS; MOUSE MODEL; HEART-RATE; LUNG; ASTHMA; RESPONSES AB Ozone (O-3) is known to induce adverse pulmonary and systemic health effects. Importantly, children and older persons are considered at-risk populations for O-3-induced dysfunction, yet the mechanisms accounting for the age-related pulmonary responses to O-3 are uncertain. In this study, we examined age-related susceptibility to O-3 using 1mo (adolescent), 4mo (young adult), 12mo (adult) and 24mo (senescent) male Brown Norway rats exposed to filtered air or O-3 (0.25 and 1.00 ppm), 6 h/day, two days/week for 1 week (acute) or 13 weeks (subchronic). Ventilatory function, assessed by whole-body plethysmography, and bronchoalveolar lavage fluid (BALF) biomarkers of injury and inflammation were used to examine O-3-induced pulmonary effects. Relaxation time declined in all ages following the weekly exposures; however, this effect persisted only in the 24mo rats following a five days recovery, demonstrating an inability to induce adaptation commonly seen with repeated O-3 exposures. PenH was increased in all groups with an augmented response in the 4mo rats following the subchronic O-3 exposures. O-3 led to increased breathing frequency and minute volume in the 1 and 4mo animals. Markers of pulmonary permeability were increased in all age groups. Elevations in BALF gamma-glutamyl transferase activity and lung inflammation following an acute O-3 exposure were noted in only the 1 and 4mo rats, which likely received an increased effective O-3 dose. These data demonstrate that adolescent and young adult animals are more susceptible to changes in ventilation and pulmonary injury/inflammation caused by acute and episodic O-3 exposure. C1 [Snow, Samantha J.; Bass, Virginia L.; Schladweiler, Mette C.; Ledbetter, Allen D.; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Snow, Samantha J.; Bass, Virginia L.; Schladweiler, Mette C.; Ledbetter, Allen D.; Kodavanti, Urmila P.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. [Gordon, Christopher J.; Jarema, Kimberly A.; Phillips, Pamela M.; Johnstone, Andrew F.] US EPA, Tox Assessment Div, NHEERL, Res Triangle Pk, NC 27711 USA. [Bass, Virginia L.] Univ N Carolina, Sch Publ Hlth, Environm Sci & Engn, Chapel Hill, NC USA. RP Snow, SJ (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM snow.samantha@epa.gov OI Snow, Samantha/0000-0003-1812-8582 NR 60 TC 1 Z9 1 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2016 VL 28 IS 7 BP 313 EP 323 DI 10.3109/08958378.2016.1170910 PG 11 WC Toxicology SC Toxicology GA DN4LX UT WOS:000377039600003 PM 27097751 ER PT S AU Schonfeld, T AF Schonfeld, Toby BE Hughes, CL Waters, MD TI Ethical Considerations in Development of Future Therapies for Women and Children SO TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE SE Molecular and Integrative Toxicology LA English DT Article; Book Chapter DE Ethics; Regulation; Vulnerable populations; Toxicology and pregnancy; Research ethics ID PRESCRIPTION DRUG-USE; BIOMEDICAL-RESEARCH; CLINICAL-RESEARCH; PREGNANT-WOMEN; POPULATION; EXCLUSION; RISK AB Translational toxicology has the potential to equip healthcare providers with new strategies to address health effects from exposure to toxic agents, especially for women. Yet in many cases, the existence of developmental milestones is coextensive with vulnerability, such that these populations merit special protections when it comes to their participation in the very research that would yield these strategies. This chapter reviews the ethical considerations and regulatory limitations that obtain to these groups of research participants and then applies these considerations to the fundamental concepts in translational toxicology. The focus of this chapter is the development of future therapies. First, the chapter reviews the criteria for what makes research ethical, and then describes the ethical and regulatory considerations that attach to the kinds of projects necessary for the development of future therapies in translational toxicology. Following this, the chapter details considerations unique to each experimental strategy (prevention, mitigation, and reversal), and finally includes several general ethical considerations for the discipline as a whole. C1 [Schonfeld, Toby] US EPA, Program Human Res Eth & Oversight, Off Sci Advisor, 1200 Penn Ave,NW Mailcode 8105R, Washington, DC 20460 USA. RP Schonfeld, T (reprint author), US EPA, Program Human Res Eth & Oversight, Off Sci Advisor, 1200 Penn Ave,NW Mailcode 8105R, Washington, DC 20460 USA. EM schonfeld.toby@epa.gov NR 31 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER-VERLAG LONDON LTD PI GODALMING PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY, ENGLAND SN 2168-4219 BN 978-3-319-27449-2; 978-3-319-27447-8 J9 MOLEC INTEGR TOXICOL PY 2016 BP 339 EP 371 DI 10.1007/978-3-319-27449-2_12 D2 10.1007/978-3-319-27449-2 PG 33 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA BE8LB UT WOS:000376533700013 ER PT J AU deNoyelles, F Smith, VH Kastens, JH Bennett, L Lomas, JM Knapp, CW Bergin, SP Dewey, SL Chapin, BRK Graham, DW AF deNoyelles, Frank, Jr. Smith, Val H. Kastens, Jude H. Bennett, LeeAnn Lomas, John M. Knapp, Charles W. Bergin, Sean P. Dewey, Sharon L. Chapin, Bridgett R. K. Graham, David W. TI A 21-year record of vertically migrating subepilimnetic populations of Cryptomonas spp. SO INLAND WATERS LA English DT Article DE Cryptomonas; DCM; deep chlorophyll maxima; motile phytoplankton; vertical migrations ID DEEP CHLOROPHYLL MAXIMUM; MIXED WATER COLUMNS; SEASONAL SUCCESSION; PEG-MODEL; LAKE; PHYTOPLANKTON; ECOLOGY; METALIMNION; NUTRIENTS; DYNAMICS AB The vertical distribution and diel migration of Cryptomonas spp. were monitored continuously for 21 years in mesotrophic Cross Reservoir, northeast Kansas, USA. The movements of these motile algae were tracked on multiple dates during July-October of each year using in situ fluorometry and optical microscopy of Lugol's iodine-preserved samples. Episodes of subepilimnetic diel vertical migration by Cryptomonas were detected and recorded on 221 different days between 1994 and 2014, with just 2 of these years (1998 and 2013) lacking any sampling events with deep peaks sufficiently large enough to track. Whenever a subepilimnetic layer of Cryptomonas was detectable, it was generally observed to ascend toward the bottom of the epilimnion beginning approximately at sunrise; to descend toward the lake bottom during the late afternoon and evening; and to remain as a deep-dwelling population until dawn of the following day. Moreover, there was high day-to-day consistency in the absolute water column depths at which the migrating algal cells would cease their ascending or descending movement. We believe this unique and remarkable dataset comprises the most detailed record of diel migratory behavior for any planktonic freshwater alga reported for a single freshwater lake. C1 [deNoyelles, Frank, Jr.; Kastens, Jude H.; Bennett, LeeAnn; Lomas, John M.; Dewey, Sharon L.] Univ Kansas, Kansas Biol Survey, Lawrence, KS 66045 USA. [deNoyelles, Frank, Jr.; Smith, Val H.] Univ Kansas, Dept Ecol & Evolutionary Biol, Lawrence, KS 66045 USA. [Knapp, Charles W.] Univ Strathclyde, Civil & Environm Engn, Glasgow, Lanark, Scotland. [Bergin, Sean P.] US EPA, Kansas City, KS USA. [Chapin, Bridgett R. K.] Haskell Indian Nations Univ, Dept Nat Sci, Lawrence, KS USA. [Graham, David W.] Newcastle Univ, Sch Civil Engn & Geosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. RP Kastens, JH (reprint author), Univ Kansas, Kansas Biol Survey, Lawrence, KS 66045 USA. EM jkastens@ku.edu RI Knapp, Charles/D-3373-2009 OI Knapp, Charles/0000-0001-7997-8543 FU EPA/EPSCoR Grant [R821829-01-0]; University of Kansas General Research Funds program FX Long before this research on Cross Reservoir began, the senior author's interest in subepilimnetic phytoplankton came with the encouragement and support from Gene Likens on Mirror Lake, New Hampshire, USA, and David Schindler and Everett Fee at the Experimental Lakes Area (ELA) in Canada. The wonderful staff at ELA during the 1970s and 1980s and colleague Mary Moffett further set the stage and later also did work on lakes in the Snowy Range, Wyoming, with Mark Conrad, Frank Vertucci, Chris Pennuto, and Teri Leahy. At the University of Kansas Field Station and the Kansas Biological Survey, there are so many to thank, including Dean Kettle who helped develop Cross Reservoir's construction; the fine station staff; Berry Clemens for early graphics development; and Debbie Baker, Steven Wang, and N.-C. Lim for water chemistry support. Then there is the deNoyelles family-thanks to all of them for the many hours. This research was funded in part by grants from EPA/EPSCoR Grant No. R821829-01-0 and the University of Kansas General Research Funds program. NR 46 TC 0 Z9 0 U1 3 U2 6 PU FRESHWATER BIOLOGICAL ASSOC PI AMBLESIDE PA THE FERRY HOUSE, FAR SAWREY, AMBLESIDE, CUMBRIA LA22 0LP, ENGLAND SN 2044-2041 EI 2044-205X J9 INLAND WATERS JI Inland Waters PY 2016 VL 6 IS 2 BP 173 EP 184 DI 10.5268/IW-6.2.930 PG 12 WC Limnology; Marine & Freshwater Biology SC Marine & Freshwater Biology GA DM6TX UT WOS:000376486500008 ER PT J AU Woody, MC Baker, KR Hayes, PL Jimenez, JL Koo, B Pye, HOT AF Woody, Matthew C. Baker, Kirk R. Hayes, Patrick L. Jimenez, Jose L. Koo, Bonyoung Pye, Havala O. T. TI Understanding sources of organic aerosol during CalNex-2010 using the CMAQ-VBS SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID VOLATILITY BASIS-SET; CHEMICAL-TRANSPORT MODEL; MEXICO-CITY; LOS-ANGELES; PARTICLE COMPOSITION; MASS-SPECTROMETER; M-XYLENE; SECONDARY; EMISSIONS; OXIDATION AB Community Multiscale Air Quality (CMAQ) model simulations utilizing the traditional organic aerosol (OA) treatment (CMAQ-AE6) and a volatility basis set (VBS) treatment for OA (CMAQ-VBS) were evaluated against measurements collected at routine monitoring networks (Chemical Speciation Network (CSN) and Interagency Monitoring of Protected Visual Environments (IMPROVE)) and those collected during the 2010 California at the Nexus of Air Quality and Climate Change (CalNex) field campaign to examine important sources of OA in southern California. Traditionally, CMAQ treats primary organic aerosol (POA) as nonvolatile and uses a two-product framework to represent secondary organic aerosol (SOA) formation. CMAQ-VBS instead treats POA as semivolatile and lumps OA using volatility bins spaced an order of magnitude apart. The CMAQ-VBS approach underpredicted organic carbon (OC) at IMPROVE and CSN sites to a greater degree than CMAQ-AE6 due to the semivolatile POA treatment. However, comparisons to aerosol mass spectrometer (AMS) measurements collected at Pasadena, CA, indicated that CMAQ-VBS better represented the diurnal profile and primary/secondary split of OA. CMAQ-VBS SOA underpredicted the average measured AMS oxygenated organic aerosol (OOA, a surrogate for SOA) concentration by a factor of 5.2, representing a considerable improvement to CMAQ-AE6 SOA predictions (factor of 24 lower than AMS). We use two new methods, one based on species ratios (SOA/Delta CO and SOA/O-x) and another on a simplified SOA parameterization, to apportion the SOA underprediction for CMAQ-VBS to slow photochemical oxidation (estimated as 1.5 x lower than observed at Pasadena using -log(NO(x)aEuro-:aEuro-NOy)), low intrinsic SOA formation efficiency (low by 1.6 to 2 x for Pasadena), and low emissions or excessive dispersion for the Pasadena site (estimated to be 1.6 to 2.3 x too low/excessive). The first and third factors are common to CMAQ-AE6, while the intrinsic SOA formation efficiency for that model is estimated to be too low by about 7 x . From source-apportioned model results, we found most of the CMAQ-VBS modeled POA at the Pasadena CalNex site was attributable to meat cooking emissions (48 %, consistent with a substantial fraction of cooking OA in the observations). This is compared to 18 % from gasoline vehicle emissions, 13 % from biomass burning (in the form of residential wood combustion), and 8 % from diesel vehicle emissions. All 'other' inventoried emission sources (e.g., industrial, point, and area sources) comprised the final 13 %. The CMAQ-VBS semivolatile POA treatment underpredicted AMS hydrocarbon-like OA (HOA) + cooking-influenced OA (CIOA) at Pasadena by a factor of 1.8 compared to a factor of 1.4 overprediction of POA in CMAQ-AE6, but it did capture the AMS diurnal profile of HOA and CIOA well, with the exception of the midday peak. Overall, the CMAQ-VBS with its semivolatile treatment of POA, SOA from intermediate volatility organic compounds (IVOCs), and aging of SOA improves SOA model performance (though SOA formation efficiency is still 1.6-2 x too low). However, continued efforts are needed to better understand assumptions in the parameterization (e.g., SOA aging) and provide additional certainty to how best to apply existing emission inventories in a framework that treats POA as semivolatile, which currently degrades existing model performance at routine monitoring networks. The VBS and other approaches (e.g., AE6) require additional work to appropriately incorporate IVOC emissions and subsequent SOA formation. C1 [Woody, Matthew C.; Baker, Kirk R.; Pye, Havala O. T.] US EPA, Res Triangle Pk, NC 27711 USA. [Hayes, Patrick L.] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada. [Hayes, Patrick L.; Jimenez, Jose L.] Univ Colorado, NOAA, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Hayes, Patrick L.; Jimenez, Jose L.] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA. [Koo, Bonyoung] Ramboll Environ Int Corp, Novato, CA USA. RP Pye, HOT (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM pye.havala@epa.gov RI Pye, Havala/F-5392-2012; Jimenez, Jose/A-5294-2008 OI Pye, Havala/0000-0002-2014-2140; Jimenez, Jose/0000-0001-6203-1847 FU US Department of Energy; EPA; DOE (BER/ASR) [DE-SC0011105]; [CARB 11-305] FX The authors would like to acknowledge John Offenberg of the US EPA and Allan Biedler, Chris Allen, and James Beilder of CSC for their contributions to this work. This project was supported in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, US Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and EPA. Patrick L. Hayes and Jose L. Jimenez were partially supported by CARB 11-305 and DOE (BER/ASR) DE-SC0011105. NR 75 TC 6 Z9 6 U1 10 U2 20 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PY 2016 VL 16 IS 6 BP 4081 EP 4100 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DK1VG UT WOS:000374702300021 ER PT J AU DeWitt, JC Williams, WC Creech, NJ Luebke, RW AF DeWitt, Jamie C. Williams, Wanda C. Creech, N. Jonathan Luebke, Robert W. TI Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPAR alpha and T- and B-cell targeting SO JOURNAL OF IMMUNOTOXICOLOGY LA English DT Article DE PFOA; PPAR alpha; TDAR; TIAR ID PEROXISOME PROLIFERATOR; PERFLUORINATED COMPOUNDS; RISK-ASSESSMENT; IMMUNE; IMMUNOTOXICOLOGY; IMMUNOMODULATION; INVOLVEMENT; TESTS AB T-cell-dependent antibody responses (TDAR) are suppressed in female C57BL/6N mice exposed to >= 3.75 mg/kg of perfluorooctanoic acid (PFOA) for 15 days. To determine if suppression of humoral immunity by PFOA is peroxisome proliferator activated receptor alpha (PPAR alpha)-dependent and if suppression is associated with specific targeting of T-or B-cells, three separate experiments were conducted: (1) female PPAR alpha constitutive knockout (PPAR alpha KO; B6.129S4-Ppar(tm1Gonz)N12) and wild-type controls (WT; C57BL/6-Tac) exposed to 0, 7.5, or 30mg PFOA/kg for 15 days were immunized on Day 11 with a T-cell-dependent antigen and sera then collected for measures of antigen-specific IgM titers (TDAR) 5 days later; (2) female C57BL/6N WT mice exposed to 0, 0.94, 1.88, 3.75, or 7.5mg PFOA/kg for 15 days were immunized with a T-cell-independent antigen on Day 11 and sera were then collected for analyses of antigen-specific IgM titers (TIAR) 7 days later; and (3) splenic lymphocyte phenotypes were assessed in unimmunized female C57BL/6N WT mice exposed to 0, 3.75, or 7.5mg PFOA/kg for 10 days to investigate effects of PFOA in the absence of specific immunization. Separate groups of mice were immunized with a T-cell-dependent antigen after 11 days of exposure and splenic lymphocyte sub-populations were assessed after 13 or 15 days of exposure to assess numbers of stimulated cells. The results indicated that exposure to >= 1.88mg PFOA/kg suppressed the TIAR; exposure to 30mg PFOA/kg suppressed the TDAR in both PPAR alpha KO and WT mice. The percentage of splenic B-cells was unchanged. Results obtained in the PPAR alpha KO mice indicated that PPAR alpha suppression of TDAR was independent of PPAR alpha involvement. Suppression of the TIAR and the TDAR with minimal lymphocyte sub-population effects suggested that effects on humoral immunity are likely mediated by disruption of B-cell/plasma cell function. C1 [DeWitt, Jamie C.] E Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, 600 Moye Blvd, Greenville, NC 27834 USA. [Williams, Wanda C.; Luebke, Robert W.] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA. [Creech, N. Jonathan] E Carolina Univ, Dept Biol, 600 Moye Blvd, Greenville, NC 27834 USA. RP DeWitt, JC (reprint author), E Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, 600 Moye Blvd, Greenville, NC 27834 USA. EM dewittj@ecu.edu OI DeWitt, Jamie/0000-0002-0440-4059 FU Undergraduate Research and Creative Activity Award from the ECU Office of Undergraduate Research; ECU Summer Biomedical Research Program (SBRP) FX We would like to thank Dr Deborah Keil and Dr David Lehmann for reviewing the manuscript for scientic accuracy and grammatical clarity. N. J. Creech was supported, in part, by an Undergraduate Research and Creative Activity Award from the ECU Office of Undergraduate Research and through the ECU Summer Biomedical Research Program (SBRP). This report has been reviewed by the Environmental Protection Agency's Office of Research and Development, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 24 TC 2 Z9 2 U1 0 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1547-691X EI 1547-6901 J9 J IMMUNOTOXICOL JI J. Immunotoxicol. PY 2016 VL 13 IS 1 BP 38 EP 45 DI 10.3109/1547691X.2014.996682 PG 8 WC Toxicology SC Toxicology GA DK4JB UT WOS:000374882900005 PM 25594567 ER PT J AU Dignam, T Garcia, BR De Leon, M Curtis, G Creanga, AA Azofeifa, A O'Neill, M Blanton, C Kennedy, C Rullan, M Caldwell, K Rullan, J Brown, MJ AF Dignam, Timothy Garcia, Brenda Rivera De Leon, Maridali Curtis, Gerald Creanga, Andreea A. Azofeifa, Alejandro O'Neill, Maureen Blanton, Curtis Kennedy, Chinaro Rullan, Maria Caldwell, Kathy Rullan, John Brown, Mary Jean TI Prevalence of Elevated Blood Lead Levels and Risk Factors Among Residents Younger Than 6 Years, Puerto Rico-2010 SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE Blood lead level; Children; Lead; Puerto Rico ID CHILDREN; EXPOSURE; FINGERSTICK; CAPILLARY; WORKERS; SAMPLES; MODEL; AGE AB Context: Limited data exist about blood lead levels (BLLs) and potential exposures among children living in Puerto Rico. The Puerto Rico Department of Health has no formal blood lead surveillance program. Objectives: We assessed the prevalence of elevated BLLs (>= 5 micrograms of lead per deciliter of blood), evaluated household environmental lead levels, and risk factors for BLL among children younger than 6 years of age living in Puerto Rico in 2010. Methods: We used a population-based, cross-sectional sampling strategy to enroll an island-representative sample of Puerto Rican children younger than 6 years. We estimated the island-wide weighted prevalence of elevated BLLs and conducted bivariable and multivariable linear regression analyses to ascertain risk factors for elevated BLLs. Results: The analytic data set included 355 households and 439 children younger than 6 years throughout Puerto Rico. The weighted geometric mean BLL of children younger than 6 years was 1.57 mu g/dL (95% confidence interval [CI], 1.27-1.88). The weighted prevalence of children younger than 6 years with BLLs of 5 mu g/dL or more was 3.18% (95% CI, 0.93-5.43) and for BLLs of 10 mu g/dL or more was 0.50% (95% CI, 0-1.31). Higher mean BLLs were significantly associated with data collection during the summer months, a lead-related activity or hobby of anyone in the residence, and maternal education of less than 12 years. Few environmental lead hazards were identified. Conclusions: The prevalence of elevated BLLs among Puerto Rican children younger than 6 years is comparable with the most recent (2007-2010) US national estimate (BLLs >= 5 mu g/dL = 2.6% [95% CI = 1.6-4.0]). Our findings suggest that targeted screening of specific higher-risk groups of children younger than 6 years can replace island-wide or insurance-specific policies of mandatory blood lead testing in Puerto Rico. C1 [Dignam, Timothy; Curtis, Gerald; Kennedy, Chinaro; Brown, Mary Jean] Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Creanga, Andreea A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Azofeifa, Alejandro] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA. [Blanton, Curtis] Ctr Dis Control & Prevent, Div Global Hlth Protect, Natl Ctr Global Hlth, Atlanta, GA 30341 USA. [Caldwell, Kathy] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Garcia, Brenda Rivera; De Leon, Maridali] Puerto Rico Dept Publ Hlth, San Juan, PR USA. [O'Neill, Maureen] US EPA, Reg 2, New York, NY USA. RP Dignam, T (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy,MS F-60, Atlanta, GA 30341 USA. EM tdignam@cdc.gov FU US Environmental Protection Agency [CE-10-010]; Centers for Disease Control and Prevention FX The project was funded by the US Environmental Protection Agency (Interagency Agreement no. CE-10-010) and the Centers for Disease Control and Prevention. The authors thank the following individuals for their dedication and hard work, making this project successful: Darielys Cordero, Catherine Chacin, Ahmad Baghal, Margie Walling, Encijar Hassan Rios, Jeff Jarrett, Charles Dodson, Carrie Dooyema, Sharunda Buchanan, W. Dana Flanders, Concepcion Q. Longo, Ginger Chew, Elizabeth Hunsperger, Kathy Seikel, Luz B. Mojica, Norma Diaz, Edna Diaz, Julio Cadiz, Sandra Claudio Luciano, Mildred Rivera Luna, Magaly Escalera, Rachel Avchen, Payal Shah, Arie Manangan, Jennifer Cruz (CRIM) Ulises Feliciano Troche (CRIM) and Olga Cruz. NR 37 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2016 VL 22 IS 1 BP E22 EP E35 DI 10.1097/PHH.0000000000000224 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DK9EI UT WOS:000375233200005 PM 25822901 ER PT J AU Humayun, MT Divan, R Liu, YZ Gundel, L Solomon, PA Paprotny, I AF Humayun, Md Tanim Divan, Ralu Liu, Yuzi Gundel, Lara Solomon, Paul A. Paprotny, Igor TI Novel chemoresistive CH4 sensor with 10 ppm sensitivity based on multiwalled carbon nanotubes functionalized with SnO2 nanocrystals SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID ATOMIC LAYER DEPOSITION; GAS SENSOR; ROOM-TEMPERATURE; SENSING CHARACTERISTICS; PLASMA TREATMENT; VANADIUM-OXIDE; THIN-FILMS; METHANE; RAMAN; NANOCOMPOSITE AB Chemoresistive sensors based on multiwalled carbon nanotubes (MWCNTs) functionalized with SnO2 nanocrystals (NCs) have great potential for detecting trace gases at low concentrations (single ppm levels) at room temperature, because the SnO2 nanocrystals act as active sites for the chemisorption of gas molecules, and carbon nanotubes (CNTs) act as an excellent current carrying platform, allowing the adsorption of gas on SnO2 to modulate the resistance of the CNTs. However, uniform conjugation of SnO2 NCs with MWCNTs is challenging. An effective atomic layer deposition based approach to functionalize the surface of MWCNTs with SnO2 NCs, resulting in a novel CH4 sensor with 10 ppm sensitivity, is presented in this paper. Scanning electron microscopy, transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy, and Raman spectroscopy were implemented to study the morphology, elemental composition, and the crystal quality of SnO2 functionalized MWCNTs. High resolution TEM images showed that the crystal quality of the functionalizing SnO2 NCs was of high quality with clear lattice fringes and the dimension almost three times smaller than shown thus far in literature. A lift-off based photolithography technique comprising bilayer photoresists was optimized to fabricate SnO2 functionalized MWCNTs-based chemoresistor sensor, which at room temperature can reliably sense below 10 ppm of CH4 in air. Such low level gas sensitivity, with significant reversible relative resistance change, is believed to be the direct result of the successful functionalization of the MWCNT surface by SnO2 NCs. (C) 2015 American Vacuum Society. C1 [Humayun, Md Tanim; Paprotny, Igor] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. [Divan, Ralu; Liu, Yuzi] Argonne Natl Lab, Ctr Nanoscale Mat, Lemont, IL 60439 USA. [Gundel, Lara] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Solomon, Paul A.] US EPA, Las Vegas, NV 89199 USA. RP Paprotny, I (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. EM paprotny@uic.edu FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; Aclima Inc. [2015-07496] FX The authors would like to thank Alex B. Martinson for SnO2 deposition by ALD and Daniel Rosenmann for metal deposition. Use of the Center for Nanoscale Materials, an Office of Science user facility, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. The project is also in part funded by a grant from Aclima Inc., award No. 2015-07496. The U.S. Environmental Protection Agency, through its Office of Research and Development, collaborated in the research described here. It has been subjected to Agency review and approved for publication. NR 38 TC 1 Z9 1 U1 11 U2 19 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 EI 1520-8559 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JAN PY 2016 VL 34 IS 1 AR 01A131 DI 10.1116/1.4936384 PG 7 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA DK7OO UT WOS:000375115800032 ER PT J AU Rathi, AK Gawande, MB Pechousek, J Tucek, J Aparicio, C Petr, M Tomanec, O Krikavova, R Travnicek, Z Varma, RS Zboril, R AF Rathi, Anuj K. Gawande, Manoj B. Pechousek, Jiri Tucek, Jiri Aparicio, Claudia Petr, Martin Tomanec, Ondrej Krikavova, Radka Travnicek, Zdenek Varma, Rajender S. Zboril, Radek TI Maghemite decorated with ultra-small palladium nanoparticles (gamma-Fe2O3-Pd): applications in the Heck-Mizoroki olefination, Suzuki reaction and allylic oxidation of alkenes SO GREEN CHEMISTRY LA English DT Article ID CROSS-COUPLING REACTIONS; CORE-SHELL NANOPARTICLES; MECHANOCHEMICAL SYNTHESIS; ORGANIC-SYNTHESIS; PD NANOPARTICLES; ARYL HALIDES; CATALYST; REDUCTION; EFFICIENT; SILICA AB A nanocatalyst comprising ultra-small Pd/PdO nanoparticles (< 5 nm) supported on maghemite was prepared by a co-precipitation protocol using inexpensive raw materials and was deployed successfully in various significant synthetic transformations, namely the Heck-Mizoroki olefination (up to 95%), the Suzuki reaction (60-95%), and the allylic oxidation of alkenes under milder conditions. The chemical nature, morphology, size, and loading of palladium nanoparticles over the magnetic support were studied by TEM/EDX, HAADF-STEM chemical mapping, XPS, AAS, and in-field Fe-57 Mossbauer spectroscopy. The cost-effective catalyst could be easily separated from the reaction mixture by using an external magnet and reused four times without any loss of activity; chemical stability and recyclability aspects of the catalyst were investigated. C1 [Rathi, Anuj K.; Gawande, Manoj B.; Pechousek, Jiri; Tucek, Jiri; Aparicio, Claudia; Petr, Martin; Tomanec, Ondrej; Zboril, Radek] Palacky Univ, Reg Ctr Adv Technol & Mat, Fac Sci, Dept Phys Chem, Slechtitelu 27, Olomouc 78371, Czech Republic. [Rathi, Anuj K.; Gawande, Manoj B.; Pechousek, Jiri; Tucek, Jiri; Aparicio, Claudia; Petr, Martin; Tomanec, Ondrej; Zboril, Radek] Palacky Univ, Reg Ctr Adv Technol & Mat, Fac Sci, Dept Expt Phys, Slechtitelu 27, Olomouc 78371, Czech Republic. [Krikavova, Radka; Travnicek, Zdenek] Palacky Univ, Reg Ctr Adv Technol & Mat, Fac Sci, Dept Inorgan Chem, Slechtitelu 27, Olomouc 78371, Czech Republic. [Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA. RP Gawande, MB; Zboril, R (reprint author), Palacky Univ, Reg Ctr Adv Technol & Mat, Fac Sci, Dept Phys Chem, Slechtitelu 27, Olomouc 78371, Czech Republic. EM manoj.gawande@upol.cz; radek.zboril@upol.cz RI Petr, Martin/B-9628-2016; Zboril, Radek/F-5153-2015 OI Petr, Martin/0000-0002-7334-6147; FU Ministry of Education, Youth and Sports of the Czech Republic [LO1305]; Technology Agency of the Czech Republic "Competence Centres" [TE01020218]; Operational Program Education for Competitiveness - European Social Fund of the Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.07/2.3.00/30.0041, CZ.1.07/2.4.00/31.0189]; Palacky University; IGA [IGA-PrF-2015-017] FX The authors thank Ms J. Stranska for TEM, David Milde and Radka Kralova for elemental analysis, and Dr V. Ranc for GC analysis. The authors acknowledge support from the Ministry of Education, Youth and Sports of the Czech Republic (LO1305), by Technology Agency of the Czech Republic "Competence Centres" (project TE01020218), by the Operational Program Education for Competitiveness - European Social Fund (project CZ.1.07/2.3.00/30.0041 and CZ.1.07/2.4.00/31.0189) of the Ministry of Education, Youth and Sports of the Czech Republic. The work is also funded by the Palacky University Institutional support and IGA grant (Project No. IGA-PrF-2015-017). NR 67 TC 14 Z9 14 U1 21 U2 43 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 8 BP 2363 EP 2373 DI 10.1039/c5gc02264a PG 11 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DJ7SU UT WOS:000374413300014 ER PT J AU Wickham, J Neale, A Mehaffey, M Jarnagin, T Norton, D AF Wickham, J. Neale, A. Mehaffey, M. Jarnagin, T. Norton, D. TI Temporal Trends in the Spatial Distribution of Impervious Cover Relative to Stream Location SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE Clean Water Act; change detection; impervious cover; National Land Cover Database; spatial pattern ID CONTERMINOUS UNITED-STATES; LAND-COVER; HEADWATER STREAMS; URBANIZATION; SURFACE; AREA; PATTERNS; IMPACTS; SCALES; CONNECTIVITY AB Use of impervious cover is transitioning from an indicator of surface water condition to one that also guides and informs watershed planning and management, including Clean Water Act (33 U.S.C. 1251 et seq.) reporting. Whether it is for understanding surface water condition or planning and management, impervious cover is most commonly expressed as summary measurement (e.g., percentage watershed in impervious cover). We use the National Land Cover Database to estimate impervious cover in the vicinity of surface waters for three time periods (2001, 2006, 2011). We also compare impervious cover in the vicinity of surface waters to watershed summary estimates of impervious cover for classifying the spatial pattern of impervious cover. Between 2001 and 2011, surface water shorelines (streams and water bodies) in the vicinity of impervious cover increased nearly 10,000km. Across all time periods, approximately 27% of the watersheds in the continental United States had proximally distributed impervious cover, i.e., the percentage of impervious cover in the vicinity of surface waters was higher than its watershed summary expression. We discuss how impervious cover spatial pattern can be used to inform watershed planning and management, including reporting under the Clean Water Act. C1 [Wickham, J.; Neale, A.; Mehaffey, M.; Jarnagin, T.] US EPA, Natl Exposure Res Lab, Off Res & Dev, 79 TW Alexander Dr,Mail Drop D343-05, Res Triangle Pk, NC 27711 USA. [Norton, D.] US EPA, Off Water, Washington, DC 20460 USA. RP Wickham, J (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, 79 TW Alexander Dr,Mail Drop D343-05, Res Triangle Pk, NC 27711 USA. EM wickham.james@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. Mention of trade names does not constitute endorsement or recommendation of use. We appreciate the comments of Jay Christensen (USEPA), Michael McDonald (USEPA), and three anonymous reviewers on earlier versions of the article. NR 54 TC 1 Z9 1 U1 4 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PY 2016 VL 52 IS 2 BP 409 EP 419 DI 10.1111/1752-1688.12393 PG 11 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DI9FZ UT WOS:000373808800010 ER PT J AU Leibowitz, SG Comeleo, RL Wigington, PJ Weber, MH Sproles, EA Sawicz, KA AF Leibowitz, Scott G. Comeleo, Randy L. Wigington, Parker J., Jr. Weber, Marc H. Sproles, Eric A. Sawicz, Keith A. TI Hydrologic Landscape Characterization for the Pacific Northwest, USA SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE hydrologic classification; hydrologic cycle; watersheds; rivers; streams; runoff; geospatial analysis; National Hydrography Dataset; NHD; Pacific Northwest ID CONTERMINOUS UNITED-STATES; CATCHMENT CLASSIFICATION; CLIMATE-CHANGE; FLOW REGIMES; OREGON; FRAMEWORK; STREAMS; RIVER; PRECIPITATION; TEMPERATURE AB We update the Wigington etal. (2013) hydrologic landscape (HL) approach to make it more broadly applicable and apply the revised approach to the Pacific Northwest (PNW; i.e., Oregon, Washington, and Idaho). Specific changes incorporated are the use of assessment units based on National Hydrography Dataset Plus V2 catchments, a modified snowmelt model validated over a broader area, an aquifer permeability index that does not require preexisting aquifer permeability maps, and aquifer and soil permeability classes based on uniform criteria. Comparison of Oregon results for the revised and original approaches found fewer and larger assessment units, loss of summer seasonality, and changes in rankings and proportions of aquifer and soil permeability classes. Differences could be explained by three factors: an increased assessment unit size, a reduced number of permeability classes, and use of smaller cutoff values for the permeability classes. The distributions of the revised HLs in five groups of Oregon rivers were similar to the original HLs but less variable. The improvements reported here should allow the revised HL approach to be applied more often insituations requiring hydrologic classification and allow greater confidence in results. We also apply the map results to the development of hydrologic landscape regions. C1 [Leibowitz, Scott G.; Comeleo, Randy L.; Wigington, Parker J., Jr.; Weber, Marc H.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. [Sproles, Eric A.] Univ La Serena, Ctr Adv Studies Arid Zones, La Serena, Chile. [Sawicz, Keith A.] US EPA, Oak Ridge Inst Sci & Educ, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. RP Leibowitz, SG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM leibowitz.scott@epa.gov OI Weber, Marc/0000-0002-9742-4744 FU U.S. Environmental Protection Agency FX We thank James Wickham and Mohammad Safeeq for providing valuable comments that improved this article. The information in this document has been funded entirely by the U.S. Environmental Protection Agency, in part through an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. This article has been subjected to Agency review and has been approved for publication. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 49 TC 0 Z9 0 U1 8 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PY 2016 VL 52 IS 2 BP 473 EP 493 DI 10.1111/1752-1688.12402 PG 21 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DI9FZ UT WOS:000373808800014 ER PT J AU McManus, MG Pond, GJ Reynolds, L Griffith, MB AF McManus, Michael G. Pond, Gregory J. Reynolds, Lou Griffith, Michael B. TI Multivariate Condition Assessment of Watersheds with Linked Micromaps SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE ecological assessment; geospatial analysis; invertebrates; linked micromap; spatial autocorrelation; stressor; stream monitoring ID LAND-USE; WADEABLE STREAMS; ECOLOGICAL IMPAIRMENT; UNITED-STATES; VALLEY FILLS; QUALITY; FISH; ECOREGIONS; INDICATORS; RESOURCES AB A challenge for statewide stream monitoring is visualizing the spatial and statistical characteristics of such data to compare the biotic condition of watersheds and relate that condition to watershed-level estimates of instream variables. We used linked micromaps on stream survey data of 25 subbasins (766-5,982km(2)) for biotic condition, nine water quality, and twohabitat variables. Subbasin biotic condition was negatively correlated with conductivity, magnesium and sulfate concentrations, and weakly positively correlated with habitat scores of sedimentation and embeddedness, with higher scores indicating better habitat. Positive spatial autocorrelation was detected among the subbasins in both habitat variables, iron concentration, pH, and exceedances of fecal coliform criteria as shown in linked micromaps. A spatial principal components analysis reduced the 11 environmental variables to two principal axes. The first axis synthesized a gradient of water quality and habitat scores among the subbasins. Subbasin biotic condition regressed on first axis subbasin scores had a significant, negative slope and accounted for 55% of the variation. Subbasins in degraded biotic condition had elevated conductivities and ion concentrations in northern and southern subbasins, and low habitat scores in western subbasins. Through linked micromaps, we compared the biotic condition among subbasins and identified stressors prevalent among subbasins that affected biotic condition. C1 [McManus, Michael G.; Griffith, Michael B.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, 26 W Martin Luther King Dr,MS A110, Cincinnati, OH 45268 USA. [Pond, Gregory J.; Reynolds, Lou] US EPA, Off Monitoring & Assessment, Environm Assessment & Innovat Div, Reg 3, Wheeling, WV 26003 USA. RP McManus, MG (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, 26 W Martin Luther King Dr,MS A110, Cincinnati, OH 45268 USA. EM mcmanus.michael@epa.gov OI McManus, Michael/0000-0003-4200-6446 NR 67 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PY 2016 VL 52 IS 2 BP 494 EP 507 DI 10.1111/1752-1688.12399 PG 14 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DI9FZ UT WOS:000373808800015 ER PT J AU Yu, YRA Hotten, DF Malakhau, Y Volker, E Ghio, AJ Noble, PW Kraft, M Hollingsworth, JW Gunn, MD Tighe, RM AF Yu, Yen-Rei A. Hotten, Danielle F. Malakhau, Yuryi Volker, Ellen Ghio, Andrew J. Noble, Paul W. Kraft, Monica Hollingsworth, John W. Gunn, Michael D. Tighe, Robert M. TI Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article DE alveolar macrophages; interstitial-associated macrophages; interstitial macrophages; interstitial lung disease ID IDIOPATHIC PULMONARY-FIBROSIS; ALVEOLAR MACROPHAGES; MANNOSE RECEPTOR; T-CELLS; DISEASE; ACTIVATION; SUBSETS; IDENTIFICATION; INFLAMMATION; PHENOTYPE AB Clear identification of specific cell populations by flow cytometry is important to understand functional roles. A well-defined flow cytometry panel for myeloid cells in human bronchoalveolar lavage (BAL) and lung tissue is currently lacking. The objective of this study was to develop a flow cytometry-based panel for human BAL and lung tissue. We obtained and performed flow cytometry/sorting on human BAL cells and lung tissue. Confocal images were obtained from lung tissue using antibodies for cluster of differentiation (CD) 206, CD169, and E cadherin. We defined a multicolor flow panel for human BAL and lung tissue that identifies major leukocyte populations. These include macrophage (CD206(+)) subsets and other CD206(-) leukocytes. The CD206(-) cells include: (1) three monocyte (CD14(+)) subsets, (2) CD11c(+) dendritic cells (CD14(-), CD11c(+), HLA-DR+), (3) plasmacytoid dendritic cells (CD14(-), CD11c(-), HLA-DR+, CD123(+)), and (4) other granulocytes (neutrophils, mast cells, eosinophils, and basophils). Using this panel on human lung tissue, we defined two populations of pulmonary macrophages: CD169(+) and CD169(-) macrophages. In lung tissue, CD169(+) macrophages were a prominent cell type. Using confocal microscopy, CD169(+) macrophages were located in the alveolar space/airway, defining them as alveolar macrophages. In contrast, CD169(+) macrophages were associated with airway/alveolar epithelium, consistent with interstitial-associated macrophages. We defined a flow cytometry panel in human BAL and lung tissue that allows identification of multiple immune cell types and delineates alveolar from interstitial-associated macrophages. This study has important implications for defining myeloid cells in human lung samples. C1 [Yu, Yen-Rei A.; Hotten, Danielle F.; Malakhau, Yuryi; Volker, Ellen; Kraft, Monica; Gunn, Michael D.; Tighe, Robert M.] Duke Univ, Dept Med, Durham, NC USA. [Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. [Noble, Paul W.] Cedar Sinai Med Ctr, Dept Med, Los Angeles, CA USA. [Hollingsworth, John W.] Ohio State Univ, Dept Med, Med Ctr, Columbus, OH 43210 USA. RP Tighe, RM (reprint author), Duke Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, Box 103000, Durham, NC 27710 USA. EM robert.tighe@duke.edu OI Tighe, Robert/0000-0002-3465-9861 FU Pulmonary Hypertension Association Proof of Concept Grant; Mandel Foundation Fellowship Grant [P01 HL108793, R01 ES020350, K08 HL105537] FX This work was supported by the Pulmonary Hypertension Association Proof of Concept Grant (Y.-R.A.Y.), the Mandel Foundation Fellowship Grant (Y.-R.A.Y.), P01 HL108793 (P.W.N.), R01 ES020350 (J.W.H.), and K08 HL105537 (R.M.T.). NR 38 TC 12 Z9 12 U1 3 U2 5 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1044-1549 EI 1535-4989 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD JAN PY 2016 VL 54 IS 1 BP 13 EP 24 DI 10.1165/rcmb.2015-0146OC PG 12 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA DI7TP UT WOS:000373705200003 PM 26267148 ER PT J AU Klionsky, DJ Abdelmohsen, K Abe, A Abedin, MJ Abeliovich, H Arozena, AA Adachi, H Adams, CM Adams, PD Adeli, K Adhihetty, PJ Adler, SG Agam, G Agarwal, R Aghi, MK Agnello, M Agostinis, P Aguilar, PV Aguirre-Ghiso, J Airoldi, EM Ait-Si-Ali, S Akematsu, T Akporiaye, ET Al-Rubeai, M Albaiceta, GM Albanese, C Albani, D Albert, ML Aldudo, J Algul, H Alirezaei, M Alloza, I Almasan, A Almonte-Beceril, M Alnemri, ES Alonso, C Altan-Bonnet, N Altieri, DC Alvarez, S Alvarez-Erviti, L Alves, S Amadoro, G Amano, A Amantini, C Ambrosio, S Amelio, I Amer, AO Amessou, M Amon, A An, ZY Anania, FA Andersen, SU Andley, UP Andreadi, CK Andrieu-Abadie, N Anel, A Ann, DK Anoopkumar-Dukie, S Antonioli, M Aoki, H Apostolova, N Aquila, S Aquilano, K Araki, K Arama, E Aranda, A Araya, J Arcaro, A Arias, E Arimoto, H Ariosa, AR Armstrong, JL Arnould, T Arsov, I Asanuma, K Askanas, V Asselin, E Atarashi, R Atherton, SS Atkin, JD Attardi, LD Auberger, P Auburger, G Aurelian, L Autelli, R Avagliano, L Avantaggiati, ML Avrahami, L Awale, S Azad, N Bachetti, T Backer, JM Bae, DH Bae, JS Bae, ON Bae, SH Baehrecke, EH Baek, SH Baghdiguian, S Bagniewska-Zadworna, A Bai, H Bai, J Bai, XY Bailly, Y Balaji, KN Balduini, W Ballabio, A Balzan, R Banerjee, R Banhegyi, G Bao, HJ Barbeau, B Barrachina, MD Barreiro, E Bartel, B Bartolome, A Bassham, DC Bassi, MT Bast, RC Basu, A Batista, MT Batoko, H Battino, M Bauckman, K Baumgarner, BL Bayer, KU Beale, R Beaulieu, JF Beck, GR Becker, C Beckham, JD Bedard, PA Bednarski, PJ Begley, TJ Behl, C Behrends, C Behrens, GMN Behrns, KE Bejarano, E Belaid, A Belleudi, F Benard, G Berchem, G Bergamaschi, D Bergami, M Berkhout, B Berliocchi, L Bernard, A Bernard, M Bernassola, F Bertolotti, A Bess, AS Besteiro, S Bettuzzi, S Bhalla, S Bhattacharyya, S Bhutia, SK Biagosch, C Bianchi, MW Biard-Piechaczyk, M Billes, V Bincoletto, C Bingol, B Bird, SW Bitoun, M Bjedov, I Blackstone, C Blanc, L Blanco, GA Blomhoff, HK Boada-Romero, E Bockler, S Boes, M Boesze-Battaglia, K Boise, LH Bolino, A Boman, A Bonaldo, P Bordi, M Bosch, J Botana, LM Botti, J Bou, G Bouche, M Bouchecareilh, M Boucher, MJ Boulton, ME Bouret, SG Boya, P Boyer-Guittaut, M Bozhkov, PV Brady, N Braga, VMM Brancolini, C Braus, GH Bravo-San Pedro, JM Brennan, LA Bresnick, EH Brest, P Bridges, D Bringer, MA Brini, M Brito, GC Brodin, B Brookes, PS Brown, EJ Brown, K Broxmeyer, HE Bruhat, A Brum, PC Brumell, JH Brunetti-Pierri, N Bryson-Richardson, RJ Buch, S Buchan, AM Budak, H Bulavin, DV Bultman, SJ Bultman, SJ Bumbasirevic, V Burelle, Y Burke, RE Burmeister, M Butikofer, P Caberlotto, L Cadwell, K Cahova, M Cai, DS Cai, JJ Cai, Q Calatayud, S Camougrand, N Campanella, M Campbell, GR Campbell, M Campello, S Candau, R Caniggia, I Cantoni, L Cao, LZ Caplan, AB Caraglia, M Cardinali, C Cardoso, SM Carew, JS Carleton, LA Carlin, CR Carloni, S Carlsson, SR Carmona-Gutierrez, D Carneiro, LAM Carnevali, O Carra, S Carrier, A Carroll, B Casas, C Casas, J Cassinelli, G Castets, P Castro-Obregon, S Cavallini, G Ceccherini, I Cecconi, F Cederbaum, AI Cena, V Cenci, S Cerella, C Cervia, D Cetrullo, S Chaachouay, H Chae, HJ Chagin, AS Chai, CY Chakrabarti, G Chamilos, G Chan, EYW Chan, MTV Chandra, D Chandra, P Chang, CP Chang, RCC Chang, TY Chatham, JC Chatterjee, S Chauhan, S Che, YS Cheetham, ME Cheluvappa, R Chen, CJ Chen, G Chen, GC Chen, GQ Chen, HZ Chen, JW Chen, JK Chen, M Chen, MZ Chen, PW Chen, Q Chen, Q Chen, SD Chen, S Chen, SSL Chen, W Chen, WJ Chen, WQ Chen, WL Chen, XM Chen, YH Chen, YG Chen, Y Chen, YY Chen, YS Chen, YJ Chen, YQ Chen, YJ Chen, Z Chen, Z Cheng, A Cheng, CHK Cheng, H Cheong, HS Cherry, S Chesney, J Cheung, CHA Chevet, E Chi, HC Chi, SG Chiacchiera, F Chiang, HL Chiarelli, R Chiariello, M Chieppa, M Chin, LS Chiong, M Chiu, GNC Cho, DH Cho, SG Cho, WC Cho, YY Cho, YS Choi, AMK Choi, EJ Choi, EK Choi, JY Choi, ME Choi, SI Chou, TF Chouaib, S Choubey, D Choubey, V Chow, KC Chowdhury, K Chu, CT Chuang, TH Chun, T Chung, HW Chung, TJ Chung, YL Chwae, YJ Cianfanelli, V Ciarcia, R Ciechomska, IA Ciriolo, MR Cirone, M Claerhout, S Clague, MJ Claria, J Clarke, PGH Clarke, R Clementi, E Cleyrat, C Cnop, M Coccia, EM Cocco, T Codogno, P Coers, J Cohen, EEW Colecchia, D Coletto, L Coll, NS Colucci-Guyon, E Comincini, S Condello, M Cook, KL Coombs, GH Cooper, CD Cooper, JM Coppens, I Corasaniti, MT Corazzari, M Corbalan, R Corcelle-Termeau, E Cordero, MD Corral-Ramos, C Corti, O Cossarizza, A Costelli, P Costes, S Costes, S Coto-Montes, A Cottet, S Couve, E Covey, LR Cowart, LA Cox, JS Coxon, FP Coyne, CB Cragg, MS Craven, RJ Crepaldi, T Crespo, JL Criollo, A Crippa, V Cruz, MT Cuervo, AM Cuezva, JM Cui, TX Cutillas, PR Czaja, MJ Czyzyk-Krzeska, MF Dagda, RK Dahmen, U 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FY Song, HK Song, JX Song, W Soo, KY Sood, AK Soong, TW Soontornniyomkij, V Sorice, M Sotgia, F Soto-Pantoja, DR Sotthibundhu, A Sousa, MJ Spaink, HP Span, PN Spang, A Sparks, JD Speck, PG Spector, SA Spies, CD Springer, W St Clair, D Stacchiotti, A Staels, B Stang, MT Starczynowski, DT Starokadomskyy, P Steegborn, C Steele, JW Stefanis, L Steffan, J Stellrecht, CM Stenmark, H Stepkowski, TM Stern, ST Stevens, C Stockwell, BR Stoka, V Storchova, Z Stork, B Stratoulias, V Stravopodis, DJ Strnad, P Strohecker, AM Strom, AL Stromhaug, P Stulik, J Su, YX Su, ZL Subauste, CS Subramaniam, S Sue, CM Suh, SW Sui, XB Sukseree, S Sulzer, D Sun, FL Sun, JR Sun, J Sun, SY Sun, Y Sun, Y Sun, YJ Sundaramoorthy, V Sung, J Suzuki, H Suzuki, K Suzuki, N Suzuki, T Suzuki, YJ Swanson, MS Swanton, C Sward, K Swarup, G Sweeney, ST Sylvester, PW Szatmari, Z Szegezdi, E Szlosarek, PW Taegtmeyer, H Tafani, M Taillebourg, E Tait, SWG Takacs-Vellai, K Takahashi, Y Takats, S Takemura, G Takigawa, N Talbot, NJ 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Chai, Chee-Yin Chakrabarti, Gopal Chamilos, Georgios Chan, Edmond Y. W. Chan, Matthew T. V. Chandra, Dhyan Chandra, Pallavi Chang, Chih-Peng Chang, Raymond Chuen-Chung Chang, Ta Yuan Chatham, John C. Chatterjee, Saurabh Chauhan, Santosh Che, Yongsheng Cheetham, Michael E. Cheluvappa, Rajkumar Chen, Chun-Jung Chen, Gang Chen, Guang-Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W. Chen, Jian-Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang-Der Chen, Si Chen, Steve S-L Chen, Wei Chen, Wei-Jung Chen, Wen Qiang Chen, Wenli Chen, Xiangmei Chen, Yau-Hung Chen, Ye-Guang Chen, Yin Chen, Yingyu Chen, Yongshun Chen, Yu-Jen Chen, Yue-Qin Chen, Yujie Chen, Zhen Chen, Zhong Cheng, Alan Cheng, Christopher H. K. Cheng, Hua Cheong, Heesun Cherry, Sara Chesney, Jason Cheung, Chun Hei Antonio Chevet, Eric Chi, Hsiang Cheng Chi, Sung-Gil Chiacchiera, Fulvio Chiang, Hui-Ling Chiarelli, Roberto Chiariello, Mario Chieppa, Marcello Chin, Lih-Shen Chiong, Mario Chiu, Gigi N. C. 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Gannage, Monique Gao, Fen-Biao Gao, Feng Gao, Jian-Xin Garcia Nannig, Lorena Vescovi, Eleonora Garcia Garcia-Macia, Marina Garcia-Ruiz, Carmen Garg, Abhishek D. Garg, Pramod Kumar Gargini, Ricardo Gassen, Nils Christian Gatica, Damian Gatti, Evelina Gavard, Julie Gavathiotis, Evripidis Ge, Liang Ge, Pengfei Ge, Shengfang Gean, Po-Wu Gelmetti, Vania Genazzani, Armando A. Geng, Jiefei Genschik, Pascal Gerner, Lisa Gestwicki, Jason E. Gewirtz, David A. Ghavami, Saeid Ghigo, Eric Ghosh, Debabrata Giammarioli, Anna Maria Giampieri, Francesca Giampietri, Claudia Giatromanolaki, Alexandra Gibbings, Derrick J. Gibellini, Lara Gibson, Spencer B. Ginet, Vanessa Giordano, Antonio Giorgini, Flaviano Giovannetti, Elisa Girardin, Stephen E. Gispert, Suzana Giuliano, Sandy Gladson, Candece L. Glavic, Alvaro Gleave, Martin Godefroy, Nelly Gogal, Robert M., Jr. Gokulan, Kuppan Goldman, Gustavo H. Goletti, Delia Goligorsky, Michael S. Gomes, Aldrin V. Gomes, Ligia C. Gomez, Hernando Gomez-Manzano, Candelaria Gomez-Sanchez, Ruben Goncalves, Dawit A. P. Goncu, Ebru Gong, Qingqiu Gongora, Celine Gonzalez, Carlos B. Gonzalez-Alegre, Pedro Gonzalez-Cabo, Pilar Ana Gonzalez-Polo, Rosa Goping, Ing Swie Gorbea, Carlos Gorbunov, Nikolai V. Goring, Daphne R. Gorman, Adrienne M. Gorski, Sharon M. Goruppi, Sandro Goto-Yamada, Shino Gotor, Cecilia Gottlieb, Roberta A. Gozes, Illana Gozuacik, Devrim Graba, Yacine Graef, Martin Granato, Giovanna E. Grant, Gary Dean Grant, Steven Gravina, Giovanni Luca Green, Douglas R. Greenhough, Alexander Greenwood, Michael T. Grimaldi, Benedetto Gros, Frederic Grose, Charles Groulx, Jean-Francois Gruber, Florian Grumati, Paolo Grune, Tilman Guan, Jun-Lin Guan, Kun-Liang Guerra, Barbara Guillen, Carlos Gulshan, Kailash Gunst, Jan Guo, Chuanyong Guo, Lei Guo, Ming Guo, Wenjie Guo, Xu-Guang Gust, Andrea A. Gustafsson, Asa B. Gutierrez, Elaine Gutierrez, Maximiliano G. Gwak, Ho-Shin Haas, Albert Haber, James E. Hadano, Shinji Hagedorn, Monica Hahn, David R. Halayko, Andrew J. Hamacher-Brady, Anne Hamada, Kozo Hamai, Ahmed Hamann, Andrea Hamasaki, Maho Hamer, Isabelle Hamid, Qutayba Hammond, Ester M. Han, Feng Han, Weidong Handa, James T. Hanover, John A. Hansen, Malene Harada, Masaru Harhaji-Trajkovic, Ljubica Harper, J. Wade Harrath, Abdel Halim Harris, Adrian L. Harris, James Hasler, Udo Hasselblatt, Peter Hasui, Kazuhisa Hawley, Robert G. Hawley, Teresa S. He, Congcong He, Cynthia Y. He, Fengtian He, Gu He, Rong-Rong He, Xian-Hui He, You-Wen He, Yu-Ying Heath, Joan K. Hebert, Marie-Josee Heinzen, Robert A. Helgason, Gudmundur Vignir Hensel, Michael Henske, Elizabeth P. Her, Chengtao Herman, Paul K. Hernandez, Agustin Hernandez, Carlos Hernandez-Tiedra, Sonia Hetz, Claudio Hiesinger, P. Robin Higaki, Katsumi Hilfiker, Sabine Hill, Bradford G. Hill, Joseph A. Hill, William D. Hino, Keisuke Hofius, Daniel Hofman, Paul Hoeglinger, Guenter U. Hoehfeld, Joerg Holz, Marina K. Hong, Yonggeun Hood, David A. Hoozemans, Jeroen J. M. Hoppe, Thorsten Hsu, Chin Hsu, Chin-Yuan Hsu, Li-Chung Hu, Dong Hu, Guochang Hu, Hong-Ming Hu, Hongbo Hu, Ming Chang Hu, Yu-Chen Hu, Zhuo-Wei Hua, Fang Hua, Ya Huang, Canhua Huang, Huey-Lan Huang, Kuo-How Huang, Kuo-Yang Huang, Shile Huang, Shiqian Huang, Wei-Pang Huang, Yi-Ran Huang, Yong Huang, Yunfei Huber, Tobias B. Huebbe, Patricia Huh, Won-Ki Hulmi, Juha J. Hur, Gang Min Hurley, James H. Husak, Zvenyslava Hussain, Sabah N. A. Hussain, Salik Hwang, Jung Jin Hwang, Seungmin Hwang, Thomas I. S. Ichihara, Atsuhiro Imai, Yuzuru Imbriano, Carol Inomata, Megumi Into, Takeshi Iovane, Valentina Iovanna, Juan L. Iozzo, Renato V. Ip, Nancy Y. Irazoqui, Javier E. Iribarren, Pablo Isaka, Yoshitaka Isakovic, Aleksandra J. Ischiropoulos, Harry Isenberg, Jeffrey S. Ishaq, Mohammad Ishida, Hiroyuki Ishii, Isao Ishmael, Jane E. Isidoro, Ciro Isobe, Ken-ichi Isono, Erika Issazadeh-Navikas, Shohreh Itahana, Koji Itakura, Eisuke Ivanov, Andrei I. Iyer, Anand Krishnan V. Izquierdo, Jose M. Izumi, Yotaro Izzo, Valentina Jaeaettelae, Marja Jaber, Nadia Jackson, Daniel John Jackson, William T. Jacob, Tony George Jacques, Thomas S. Jagannath, Chinnaswamy Jain, Ashish Jana, Nihar Ranjan Jang, Byoung Kuk Jani, Alkesh Janji, Bassam Jannig, Paulo Roberto Jansson, Patric J. Jean, Steve Jendrach, Marina Jeon, Ju-Hong Jessen, Niels Jeung, Eui-Bae Jia, Kailiang Jia, Lijun Jiang, Hong Jiang, Hongchi Jiang, Liwen Jiang, Teng Jiang, Xiaoyan Jiang, Xuejun Jiang, Xuejun Jiang, Ying Jiang, Yongjun Jimenez, Alberto Jin, Cheng Jin, Hongchuan Jin, Lei Jin, Meiyan Jin, Shengkan Jinwal, Umesh Kumar Jo, Eun-Kyeong Johansen, Terje Johnson, Daniel E. Johnson, Gail V. W. Johnson, James D. Jonasch, Eric Jones, Chris Joosten, Leo A. B. Jordan, Joaquin Joseph, Anna-Maria Joseph, Bertrand Joubert, Annie M. Ju, Dianwen Ju, Jingfang Juan, Hsueh-Fen Juenemann, Katrin Juhasz, Gabor Jung, Hye Seung Jung, Jae U. Jung, Yong-Keun Jungbluth, Heinz Justice, Matthew J. Jutten, Barry Kaakoush, Nadeem O. Kaarniranta, Kai Kaasik, Allen Kabuta, Tomohiro Kaeffer, Bertrand Kagedal, Katarina Kahana, Alon Kajimura, Shingo Kakhlon, Or Kalia, Manjula Kalvakolanu, Dhan V. Kamada, Yoshiaki Kambas, Konstantinos Kaminskyy, Vitaliy O. Kampinga, Harm H. Kandouz, Mustapha Kang, Chanhee Kang, Rui Kang, Tae-Cheon Kanki, Tomotake Kanneganti, Thirumala-Devi Kanno, Haruo Kanthasamy, Anumantha G. Kantorow, Marc Kaparakis-Liaskos, Maria Kapuy, Orsolya Karantza, Vassiliki Karim, Md Razaul Karmakar, Parimal Kaser, Arthur Kaushik, Susmita Kawula, Thomas Kaynar, A. Murat Ke, Po-Yuan Ke, Zun-Ji Kehrl, John H. Keller, Kate E. Kemper, Jongsook Kim Kenworthy, Anne K. Kepp, Oliver Kern, Andreas Kesari, Santosh Kessel, David Ketteler, Robin Kettelhut, Isis do Carmo Khambu, Bilon Khan, Muzamil Majid Khandelwal, Vinoth K. M. Khare, Sangeeta Kiang, Juliann G. Kiger, Amy A. Kihara, Akio Kim, Arianna L. Kim, Cheol Hyeon Kim, Deok Ryong Kim, Do-Hyung Kim, Eung Kweon Kim, Hye Young Kim, Hyung-Ryong Kim, Jae-Sung Kim, Jeong Hun Kim, Jin Cheon Kim, Jin Hyoung Kim, Kwang Woon Kim, Michael D. Kim, Moon-Moo Kim, Peter K. Kim, Seong Who Kim, Soo-Youl Kim, Yong-Sun Kim, Yonghyun Kimchi, Adi Kimmelman, Alec C. Kimura, Tomonori King, Jason S. Kirkegaard, Karla Kirkin, Vladimir Kirshenbaum, Lorrie A. Kishi, Shuji Kitajima, Yasuo Kitamoto, Katsuhiko Kitaoka, Yasushi Kitazato, Kaio Kley, Rudolf A. Klimecki, Walter T. Klinkenberg, Michael Klucken, Jochen Knaevelsrud, Helene Knecht, Erwin Knuppertz, Laura Ko, Jiunn-Liang Kobayashi, Satoru Koch, Jan C. Koechlin-Ramonatxo, Christelle Koenig, Ulrich Ko, Young Ho Koehler, Katja Kohlwein, Sepp D. Koike, Masato Komatsu, Masaaki Kominami, Eiki Kong, Dexin Kong, Hee Jeong Konstantakou, Eumorphia G. Kopp, Benjamin T. Korcsmaros, Tamas Korhonen, Laura Korolchuk, Viktor I. Koshkina, Nadya V. Kou, Yanjun Koukourakis, Michael I. Koumenis, Constantinos Kovacs, Attila L. Kovacs, Tibor Kovacs, Werner J. Koya, Daisuke Kraft, Claudine Krainc, Dimitri Kramer, Helmut Kravic-Stevovic, Tamara Krek, Wilhelm Kretz-Remy, Carole Krick, Roswitha Krishnamurthy, Malathi Kriston-Vizi, Janos Kroemer, Guido Kruer, Michael C. Kruger, Rejko Ktistakis, Nicholas T. Kuchitsu, Kazuyuki Kuhn, Christian Kumar, Addanki Pratap Kumar, Anuj Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Rakesh Kumar, Sharad Kundu, Mondira Kung, Hsing-Jien Kuno, Atsushi Kuo, Sheng-Han Kuret, Jeff Kurz, Tino Kwok, Terry Kwon, Taeg Kyu Kwon, Yong Tae Kyrmizi, Irene La Spada, Albert R. Lafont, Frank Lahm, Tim Lakkaraju, Aparna Lam, Truong Lamark, Trond Lancel, Steve Landowski, Terry H. Lane, Darius J. R. Lane, Jon D. Lanzi, Cinzia Lapaquette, Pierre Lapierre, Louis R. Laporte, Jocelyn Laukkarinen, Johanna Laurie, Gordon W. Lavandero, Sergio Lavie, Lena LaVoie, Matthew J. Law, Betty Yuen Kwan Law, Helen Ka-wai Law, Kelsey B. Layfield, Robert Lazo, Pedro A. Le Cam, Laurent Le Roch, Karine G. Le Stunff, Herve Leardkamolkarn, Vijittra Lecuit, Marc Lee, Byung-Hoon Lee, Che-Hsin Lee, Erinna F. Lee, Gyun Min Lee, He-Jin Lee, Hsinyu Lee, Jae Keun Lee, Jongdae Lee, Ju-Hyun Lee, Jun Hee Lee, Michael Lee, Myung-Shik Lee, Patty J. Lee, Sam W. Lee, Seung-Jae Lee, Shiow-Ju Lee, Stella Y. Lee, Sug Hyung Lee, Sung Sik Lee, Sung-Joon Lee, Sunhee Lee, Ying-Ray Lee, Yong J. Lee, Young H. Leeuwenburgh, Christiaan Lefort, Sylvain Legouis, Renaud Lei, Jinzhi Lei, Qun-Ying Leib, David A. Leibowitz, Gil Lekli, Istvan Lemaire, Stephane D. Lemasters, John J. Lemberg, Marius K. Lemoine, Antoinette Leng, Shuilong Lenz, Guido Lenzi, Paola Lerman, Lilach O. Barbato, Daniele Lettieri Leu, Julia I-Ju Leung, Hing Y. Levine, Beth Lewis, Patrick A. Lezoualc'h, Frank Li, Chi Li, Faqiang Li, Feng-Jun Li, Jun Li, Ke Li, Lian Li, Min Li, Min Li, Qiang Li, Rui Li, Sheng Li, Wei Li, Wei Li, Xiaotao Li, Yumin Lian, Jiqin Liang, Chengyu Liang, Qiangrong Liao, Yulin Liberal, Joana Liberski, Pawel P. Lie, Pearl Lieberman, Andrew P. Lim, Hyunjung Jade Lim, Kah-Leong Lim, Kyu Lima, Raquel T. Lin, Chang-Shen Lin, Chiou-Feng Lin, Fang Lin, Fangming Lin, Fu-Cheng Lin, Kui Lin, Kwang-Huei Lin, Pei-Hui Lin, Tianwei Lin, Wan-Wan Lin, Yee-Shin Lin, Yong Linden, Rafael Lindholm, Dan Lindqvist, Lisa M. Lingor, Paul Linkermann, Andreas Liotta, Lance A. Lipinski, Marta M. Lira, Vitor A. Lisanti, Michael P. Liton, Paloma B. Liu, Bo Liu, Chong Liu, Chun-Feng Liu, Fei Liu, Hung-Jen Liu, Jianxun Liu, Jing-Jing Liu, Jing-Lan Liu, Ke Liu, Leyuan Liu, Liang Liu, Quentin Liu, Rong-Yu Liu, Shiming Liu, Shuwen Liu, Wei Liu, Xian-De Liu, Xiangguo Liu, Xiao-Hong Liu, Xinfeng Liu, Xu Liu, Xueqin Liu, Yang Liu, Yule Liu, Zexian Liu, Zhe Liuzzi, Juan P. Lizard, Gerard Ljujic, Mila Lodhi, Irfan J. Logue, Susan E. Lokeshwar, Bal L. Long, Yun Chau Lonial, Sagar Loos, Benjamin Lopez-Otin, Carlos Lopez-Vicario, Cristina Lorente, Mar Lorenzi, Philip L. Lorincz, Peter Los, Marek Lotze, Michael T. Lovat, Penny E. Lu, Binfeng Lu, Bo Lu, Jiahong Lu, Qing Lu, She-Min Lu, Shuyan Lu, Yingying Luciano, Federic Luckhart, Shirley Lucocq, John Milton Ludovico, Paula Lugea, Aurelia Lukacs, Nicholas W. Lum, Julian J. Lund, Anders H. Luo, Honglin Luo, Jia Luo, Shouqing Luparello, Claudio Lyons, Timothy Ma, Jianjie Ma, Yi Ma, Yong Ma, Zhenyi Machado, Juliano Machado-Santelli, Glaucia M. Macian, Fernando MacIntosh, Gustavo C. MacKeigan, Jeffrey P. Macleod, Kay F. MacMicking, John D. MacMillan-Crow, Lee Ann Madeo, Frank Madesh, Muniswamy Madrigal-Matute, Julio Maeda, Akiko Maeda, Tatsuya Maegawa, Gustavo Maellaro, Emilia Maes, Hannelore Magarinos, Marta Maiese, Kenneth Maiti, Tapas K. Maiuri, Luigi Maiuri, Maria Chiara Maki, Carl G. Malli, Roland Malorni, Walter Maloyan, Alina Mami-Chouaib, Fathia Man, Na Mancias, Joseph D. Mandelkow, Eva-Maria Mandell, Michael A. Manfredi, Angelo A. Manie, Serge N. Manzoni, Claudia Mao, Kai Mao, Zixu Mao, Zong-Wan Marambaud, Philippe Marconi, Anna Maria Marelja, Zvonimir Marfe, Gabriella Margeta, Marta Margittai, Eva Mari, Muriel Mariani, Francesca V. Marin, Concepcio Marinelli, Sara Marino, Guillermo Markovic, Ivanka Marquez, Rebecca Martelli, Alberto M. Martens, Sascha Martin, Katie R. Martin, Seamus J. Martin, Shaun Martin-Acebes, Miguel A. Martin-Sanz, Paloma Martinand-Mari, Camille Martinet, Wim Martinez, Jennifer Martinez-Lopez, Nuria Martinez-Outschoorn, Ubaldo Martinez-Velazquez, Moises Martinez-Vicente, Marta Martins, Waleska Kerllen Mashima, Hirosato Mastrianni, James A. Matarese, Giuseppe Matarrese, Paola Mateo, Roberto Matoba, Satoaki Matsumoto, Naomichi Matsushita, Takehiko Matsuura, Akira Matsuzawa, Takeshi Mattson, Mark P. Matus, Soledad Maugeri, Norma Mauvezin, Caroline Mayer, Andreas Maysinger, Dusica Mazzolini, Guillermo D. McBrayer, Mary Kate McCall, Kimberly McCormick, Craig McInerney, Gerald M. McIver, Skye C. McKenna, Sharon McMahon, John J. McNeish, Iain A. Mechta-Grigoriou, Fatima Medema, Jan Paul Medina, Diego L. Megyeri, Klara Mehrpour, Maryam Mehta, Jawahar L. Mei, Yide Meier, Ute-Christiane Meijer, Alfred J. Melendez, Alicia Melino, Gerry Melino, Sonia Tenorio de Melo, Edesio Jose Mena, Maria A. Meneghini, Marc D. Menendez, Javier A. Menezes, Regina Meng, Liesu Meng, Ling-hua Meng, Songshu Menghini, Rossella Menko, A. Sue Menna-Barreto, Rubem F. S. Menon, Manoj B. Meraz-Rios, Marco A. Merla, Giuseppe Merlini, Luciano Merlot, Angelica M. Meryk, Andreas Meschini, Stefania Meyer, Joel N. Mi, Man-Tian Miao, Chao-Yu Micale, Lucia Michaeli, Simon Michiels, Carine Migliaccio, Anna Rita Mihailidou, Anastasia Susie Mijaljica, Dalibor Mikoshiba, Katsuhiko Milan, Enrico Miller-Fleming, Leonor Mills, Gordon B. Mills, Ian G. Minakaki, Georgia Minassian, Berge A. Ming, Xiu-Fen Minibayeva, Farida Minina, Elena A. Mintern, Justine D. Minucci, Saverio Miranda-Vizuete, Antonio Mitchell, Claire H. Miyamoto, Shigeki Miyazawa, Keisuke Mizushima, Noboru Mnich, Katarzyna Mograbi, Baharia Mohseni, Simin Moita, Luis Ferreira Molinari, Marco Molinari, Maurizio Moller, Andreas Buch Mollereau, Bertrand Mollinedo, Faustino Monick, Martha M. Monick, Martha M. Montagnaro, Serena Montell, Craig Moore, Darren J. Moore, Michael N. Mora-Rodriguez, Rodrigo Moreira, Paula I. Morel, Etienne Morelli, Maria Beatrice Moreno, Sandra Morgan, Michael J. Moris, Arnaud Moriyasu, Yuji Morrison, Janna L. Morrison, Lynda A. Morselli, Eugenia Moscat, Jorge Moseley, Pope L. Mostowy, Serge Motori, Elisa Mottet, Denis Mottram, Jeremy C. Moussa, Charbel E-H Mpakou, Vassiliki E. Mukhtar, Hasan Levy, Jean M. Mulcahy Muller, Sylviane Munoz-Moreno, Raquel Munoz-Pinedo, Cristina Muenz, Christian Murphy, Maureen E. Murray, James T. Murthy, Aditya Mysorekar, Indira U. Nabi, Ivan R. Nabissi, Massimo Nader, Gustavo A. Nagahara, Yukitoshi Nagai, Yoshitaka Nagata, Kazuhiro Nagelkerke, Anika Nagy, Peter Naidu, Samisubbu R. Nair, Sreejayan Nakano, Hiroyasu Nakatogawa, Hitoshi Nanjundan, Meera Napolitano, Gennaro Naqvi, Naweed I. Nardacci, Roberta Narendra, Derek P. Narita, Masashi Nascimbeni, Anna Chiara Natarajan, Ramesh Navegantes, Luiz C. Nawrocki, Steffan T. Nazarko, Taras Y. Nazarko, Volodymyr Y. Neill, Thomas Neri, Luca M. Netea, Mihai G. Netea-Maier, Romana T. Neves, Bruno M. Ney, Paul A. Nezis, Ioannis P. Nguyen, Hang T. T. Huu Phuc Nguyen Nicot, Anne-Sophie Nilsen, Hilde Nilsson, Per Nishimura, Mikio Nishino, Ichizo Niso-Santano, Mireia Niu, Hua Nixon, Ralph A. Njar, Vincent C. O. Noda, Takeshi Noegel, Angelika A. Nolte, Elsie Magdalena Norberg, Erik Norga, Koenraad K. Noureini, Sakineh Kazemi Notomi, Shoji Notterpek, Lucia Nowikovsky, Karin Nukina, Nobuyuki Nuernberger, Thorsten O'Donnell, Valerie B. O'Donovan, Tracey O'Dwyer, Peter J. Oehme, Ina Oeste, Clara L. Ogawa, Michinaga Ogretmen, Besim Ogura, Yuji Oh, Young J. Ohmuraya, Masaki Ohshima, Takayuki Ojha, Rani Okamoto, Koji Okazaki, Toshiro Oliver, F. Javier Ollinger, Karin Olsson, Stefan Orban, Daniel P. Ordonez, Paulina Orhon, Idil Orosz, Laszlo O'Rourke, Eyleen J. Orozco, Helena Ortega, Angel L. Ortona, Elena Osellame, Laura D. Oshima, Junko Oshima, Shigeru Osiewacz, Heinz D. Otomo, Takanobu Otsu, Kinya Ou, Jing-hsiung James Outeiro, Tiago F. Ouyang, Dong-yun Ouyang, Hongjiao Overholtzer, Michael Ozbun, Michelle A. Ozdinler, P. Hande Ozpolat, Bulent Pacelli, Consiglia Paganetti, Paolo Page, Guylene Pages, Gilles Pagnini, Ugo Pajak, Beata Pak, Stephen C. Pakos-Zebrucka, Karolina Pakpour, Nazzy Palkova, Zdena Palladino, Francesca Pallauf, Kathrin Pallet, Nicolas Palmieri, Marta Paludan, Soren R. Palumbo, Camilla Palumbo, Silvia Pampliega, Olatz Pan, Hongming Pan, Wei Panaretakis, Theocharis Pandey, Aseem Pantazopoulou, Areti Papackova, Zuzana Papademetrio, Daniela L. Papassideri, Issidora Papini, Alessio Parajuli, Nirmala Pardo, Julian Parekh, Vrajesh V. Parenti, Giancarlo Park, Jong-In Park, Junsoo Park, Ohkmae K. Parker, Roy Parlato, Rosanna Parys, Jan B. Parzych, Katherine R. Pasquet, Jean-Max Pasquier, Benoit Pasumarthi, Kishore B. S. Patschan, Daniel Patterson, Cam Pattingre, Sophie Pattison, Scott Pause, Arnim Pavenstaedt, Hermann Pavone, Flaminia Pedrozo, Zully Pena, Fernando J. Penalva, Miguel A. Pende, Mario Peng, Jianxin Penna, Fabio Penninger, Josef M. Pensalfini, Anna Pepe, Salvatore Pereira, Gustavo J. S. Pereira, Paulo C. Perez-de la Cruz, Veronica Esther Perez-Perez, Maria Perez-Rodriguez, Diego Perez-Sala, Dolores Perier, Celine Perl, Andras Perlmutter, David H. Perrotta, Ida Pervaiz, Shazib Pesonen, Maija Pessin, Jeffrey E. Peters, Godefridus J. Petersen, Morten Petrache, Irina Petrof, Basil J. Petrovski, Goran Phang, James M. Piacentini, Mauro Pierdominici, Marina Pierre, Philippe Pierrefite-Carle, Valerie Pietrocola, Federico Pimentel-Muinos, Felipe X. Pinar, Mario Pineda, Benjamin Pinkas-Kramarski, Ronit Pinti, Marcello Pinton, Paolo Piperdi, Bilal Piret, James M. Platanias, Leonidas C. Platta, Harald W. Plowey, Edward D. Poggeler, Stefanie Poirot, Marc Polcic, Peter Poletti, Angelo Poon, Audrey H. Popelka, Hana Popova, Blagovesta Poprawa, Izabela Poulose, Shibu M. Poulton, Joanna Powers, Scott K. Powers, Ted Pozuelo-Rubio, Mercedes Prak, Krisna Prange, Reinhild Prescott, Mark Priault, Muriel Prince, Sharon Proia, Richard L. Proikas-Cezanne, Tassula Prokisch, Holger Promponas, Vasilis J. Przyklenk, Karin Puertollano, Rosa Pugazhenthi, Subbiah Puglielli, Luigi Pujol, Aurora Puyal, Julien Pyeon, Dohun Qi, Xin Qian, Wen-bin Qin, Zheng-Hong Qiu, Yu Qu, Ziwei Quadrilatero, Joe Quinn, Frederick Raben, Nina Rabinowich, Hannah Radogna, Flavia Ragusa, Michael J. Rahmani, Mohamed Raina, Komal Ramanadham, Sasanka Ramesh, Rajagopal Rami, Abdelhaq Randall-Demllo, Sarron Randow, Felix Rao, Hai Rao, V. Ashutosh Rasmussen, Blake B. Rasse, Tobias M. Ratovitski, Edward A. Rautou, Pierre-Emmanuel Ray, Swapan K. Razani, Babak Reed, Bruce H. Reggiori, Fulvio Rehm, Markus Reichert, Andreas S. Rein, Theo Reiner, David J. Reits, Eric Ren, Jun Ren, Xingcong Renna, Maurizio Reusch, Jane E. B. Revuelta, Jose L. Reyes, Leticia Rezaie, Alireza R. Richards, Robert I. Richardson, Des R. Richetta, Clemence Riehle, Michael A. Rihn, Bertrand H. Rikihisa, Yasuko Riley, Brigit E. Rimbach, Gerald Rippo, Maria Rita Ritis, Konstantinos Rizzi, Federica Rizzo, Elizete Roach, Peter J. Robbins, Jeffrey Roberge, Michel Roca, Gabriela Roccheri, Maria Carmela Rocha, Sonia Rodrigues, Cecilia M. P. Rodriguez, Clara I. Rodriguez de Cordoba, Santiago Rodriguez-Muela, Natalia Roelofs, Jeroen Rogov, Vladimir V. Rohn, Troy T. Rohrer, Baerbel Romanelli, Davide Romani, Luigina Silvia Romano, Patricia Roncero, M. Isabel G. Luis Rosa, Jose Rosello, Alicia Rosen, Kirill V. Rosenstiel, Philip Rost-Roszkowska, Magdalena Roth, Kevin A. Roue, Gael Rouis, Mustapha Rouschop, Kasper M. Ruan, Daniel T. Ruano, Diego Rubinsztein, David C. Rucker, Edmund B., III Rudich, Assaf Rudolf, Emil Rudolf, Ruediger Ruegg, Markus A. Ruiz-Roldan, Carmen Ruparelia, Avnika Ashok Rusmini, Paola Russ, David W. Russo, Gian Luigi Russo, Giuseppe Russo, Rossella Rusten, Tor Erik Ryabovol, Victoria Ryan, Kevin M. Ryter, Stefan W. Sabatini, David M. Sacher, Michael Sachse, Carsten Sack, Michael N. Sadoshima, Junichi Saftig, Paul Sagi-Eisenberg, Ronit Sahni, Sumit Saikumar, Pothana Saito, Tsunenori Saitoh, Tatsuya Sakakura, Koichi Sakoh-Nakatogawa, Machiko Sakuraba, Yasuhito Salazar-Roa, Maria Salomoni, Paolo Saluja, Ashok K. Salvaterra, Paul M. Salvioli, Rosa Samali, Afshin Sanchez, Anthony M. J. Sanchez-Alcazar, Jose A. Sanchez-Prieto, Ricardo Sandri, Marco Sanjuan, Miguel A. Santaguida, Stefano Santambrogio, Laura Santoni, Giorgio dos Santos, Claudia Nunes Saran, Shweta Sardiello, Marco Sargent, Graeme Sarkar, Pallabi Sarkar, Sovan Sarrias, Maria Rosa Sarwal, Minnie M. Sasakawa, Chihiro Sasaki, Motoko Sass, Miklos Sato, Ken Sato, Miyuki Satriano, Joseph Savaraj, Niramol Saveljeva, Svetlana Schaefer, Liliana Schaible, Ulrich E. Scharl, Michael Schatzl, Hermann M. Schekman, Randy Scheper, Wiep Schiavi, Alfonso Schipper, Hyman M. Schmeisser, Hana Schmidt, Jens Schmitz, Ingo Schneider, Bianca E. Schneider, E. Marion Schneider, Jaime L. Schon, Eric A. Schoenenberger, Miriam J. 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[Qi, Xin] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA. [Subauste, Carlos S.] Case Western Reserve Univ, Sch Med, Div Infect Dis & HIV Med, Dept Med, Cleveland, OH 44106 USA. [Vila, Miquel] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain. [Cho, Yong-Yeon] Catholic Univ Korea, Coll Pharm, Bucheon, South Korea. [Lee, Sug Hyung] Catholic Univ Korea, Seoul, South Korea. [Alves, Sandro] INSERM, CEA DSV BM 12, U1169, Gene Therapy Neurodegenerat Dis, Fontenay Aux Roses, France. [Gottlieb, Roberta A.] Barbra Streisand Womens Heart Ctr, Cedars Sinai Heart Inst, Los Angeles, CA USA. [Seki, Ekihiro] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA. [Lugea, Aurelia] VAGLAHS UCLA, Cedars Sinai Med Ctr, Pancreat Res Grp, Los Angeles, CA USA. [Jiang, Ying; Lie, Pearl; McBrayer, Mary Kate; Pensalfini, Anna; Sarkar, Pallabi] Nathan S Kline Inst, Ctr Dementia Res, Orangeburg, NY USA. 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[Krick, Roswitha; Thumm, Michael] Univ Gottingen, Inst Cellular Biochem, D-37073 Gottingen, Germany. [Liotta, Lance A.] George Mason Univ, Manassas, VA USA. [Hawley, Robert G.] George Washington Univ, Dept Anat & Regenerat Biol, Washington, DC USA. [Hawley, Teresa S.] George Washington Univ, Flow Cytometry Core Facil, Washington, DC USA. [Moussa, Charbel E-H] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA. [Clarke, Robert] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA. [Suzuki, Yuichiro J.] Georgetown Univ, Dept Physiol & Pharmacol, Washington, DC USA. [Albanese, Chris] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC USA. [Albanese, Chris] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Pathol, Washington, DC USA. [Avantaggiati, Maria Laura] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA. [Lokeshwar, Bal L.] Georgia Regents Univ, Ctr Canc, Dept Med, Augusta, GA USA. [Hill, William D.] Georgia Regents Univ, Dept Neurol, Augusta, GA USA. [Hill, William D.] Georgia Regents Univ, Dept Orthopaed Surg, Augusta, GA USA. [Hill, William D.] Georgia Regents Univ, Inst Regenerat & Reparat Med, Augusta, GA USA. [Atherton, Sally S.] Georgia Regents Univ, Med Coll Georgia, Augusta, GA USA. [Chen, Jian-Kang; Dong, Zheng; Hill, William D.; Xu, Jinxian] Georgia Regents Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA USA. [Chen, Jian-Kang; Xu, Jinxian] Georgia Regents Univ, Med Coll Georgia, Dept Med, Augusta, GA USA. [Oehme, Ina] German Canc Res Ctr, Clin Cooperat Unit CCU Pediat Oncol, Heidelberg, Germany. [Hamacher-Brady, Anne] German Canc Res Ctr, Lysosomal Syst Biol, Heidelberg, Germany. [Brady, Nathan] German Canc Res Ctr, Syst Biol Cell Death Mech, Heidelberg, Germany. [Hoeglinger, Guenter U.] German Ctr Neurodegenerat Dis DZNE, Munich, Germany. [Grune, Tilman] German Inst Human Nutr, Dept Mol Toxicol, Nuthetal, Germany. [Vandenabeele, Peter] Univ Ghent, Dept Biomed Mol Biol, Inflammat Res Ctr, VIB,Methusalem Program, B-9000 Ghent, Belgium. [Menendez, Javier A.] ICO, Girona Biomed Res Inst IDIBGI, Catalonia, Spain. [Auburger, Georg; Gispert, Suzana; Klinkenberg, Michael] Goethe Univ, Sch Med, Expt Neurol, Frankfurt, Germany. [Doetsch, Volker; Rogov, Vladimir V.] Goethe Univ Frankfurt, Inst Biophys Chem, D-60054 Frankfurt, Germany. [Dikic, Ivan; Grumati, Paolo] Goethe Univ, Sch Med, Inst Biochem 2, Frankfurt, Germany. [Dikic, Ivan; Grumati, Paolo] Buchmann Inst Mol Life, Frankfurt, Germany. [Schaefer, Liliana] Goethe Univ, Inst Pharmacol & Toxicol, Frankfurt, Germany. [Fulda, Simone] Goethe Univ, Inst Expt Canc Res Pediat, Frankfurt, Germany. [Hamann, Andrea; Knuppertz, Laura; Osiewacz, Heinz D.] Goethe Univ, Inst Mol Biosci, Mol Dev Biol, Frankfurt, Hesse, Germany. [Veras, Patricia S. T.] Fundacao Oswaldo Cruz, FIOCRUZ BA, Goncalo Moniz Res Ctr, Lab Pathol & Biointervent, Salvador, BA, Brazil. [Gwak, Ho-Shin] Grad Sch Canc Sci & Policy, Dept Syst Canc Sci, Goyang, South Korea. [Choi, Eun-Kyoung] Hallym Univ, Grad Sch, Chunchon, Kangwon Do, South Korea. [Anoopkumar-Dukie, Shailendra; Grant, Gary Dean] Griffith Univ, Menzies Hlth Inst Queensland, Nathan, Qld 4111, Australia. [Leng, Shuilong] Guangzhou Med Univ, Dept Human Anat, Sch Basic Sci, Guangzhou, Guangdong, Peoples R China. [Sakakura, Koichi] Gunma Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Gunma, Japan. [Sato, Miyuki] Gunma Univ, Lab Mol Membrane Biol, Inst Mol & Cellular Regulat, Gunma, Japan. [Sato, Ken] Gunma Univ, Lab Mol Traff, Inst Mol & Cellular Regulat, Gunma, Japan. [Bravo-San Pedro, Jose M.; Galluzzi, Lorenzo; Izzo, Valentina; Pietrocola, Federico; Sica, Valentina] Gustave Roussy Canc Campus, Villejuif, France. [Kroemer, Guido] Gustave Roussy Comprehens Canc Ctr, Villejuif, France. [Chouaib, Salem; Mami-Chouaib, Fathia] Inst Gustave Roussy, Villejuif, France. [Kim, Deok Ryong] Gyeongsang Natl Univ, Sch Med, Dept Biochem & Convergence Med Sci, JinJu, Gyeongsang, South Korea. [Kim, Deok Ryong] Inst Hlth Sci, JinJu, South Korea. [Leibowitz, Gil] Hadassah Hebrew Univ, Med Ctr, Endocrinol & Metab Serv, Dept Med, Jerusalem, Israel. [Kakhlon, Or] Hadassah Hebrew Univ, Med Ctr, Dept Neurol, Jerusalem, Israel. [Kang, Tae-Cheon] Hallym Univ, Dept Anat & Neurobiol, Coll Med, Kangwon Do, South Korea. [Choi, Eun-Kyoung] Hallym Univ, Dept Biomed Gerontol, Chunchon, Kangwon Do, South Korea. [Kim, Yong-Sun] Hallym Univ, Dept Microbiol, Coll Med, Chunchon, Gangwon, South Korea. [Ko, Young Ho] Hallym Univ, Ilsong Inst Life Sci, Chunchon, South Korea. [Suh, Sang Won] Hallym Univ, Sch Med, Dept Physiol, Chunchon, South Korea. [Azad, Neelam; Iyer, Anand Krishnan V.] Hampton Univ, Dept Pharmaceut Sci, Sch Pharm, Hampton, VA 23668 USA. [Yang, Yi] Hangzhou Normal Univ, Dept Pharmacol, Sch Med, Hangzhou, Zhejiang, Peoples R China. [Behrens, Georg M. N.] Hannover Med Sch, Dept Clin Immunol & Rheumotol, Hannover, Germany. [Gaestel, Matthias; Menon, Manoj B.] Hannover Med Sch, Dept Biochem, Hannover, Germany. [Thum, Thomas] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies IMTTS, Hannover, Germany. [Bae, Ok-Nam] Hanyang Univ, Coll Pharm, Ansan, South Korea. [Wang, Dong] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Heilongjiang, Peoples R China. [Xu, Hongwei] Harbin Med Univ, Dept Immunol, Heilongjiang Prov Key Lab Infect & Immun, Harbin, Peoples R China. [Chou, Tsui-Fen] Harbor UCLA Med Ctr, Torrance, CA 90509 USA. [Chou, Tsui-Fen] Los Angeles Biomed Res Inst, Div Med Genet, Dept Pediat, Torrance, CA USA. [Geng, Jiefei; Xavier, Ramnik J.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Xavier, Ramnik J.] Broad Inst, Boston, MA USA. [Kang, Chanhee] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Genet,Div Genet, Boston, MA 02115 USA. [Kimmelman, Alec C.; Mancias, Joseph D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Mancias, Joseph D.] Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA. [Harper, J. Wade; Yuan, Junying] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA. [Irazoqui, Javier E.] Harvard Univ, Sch Med, Lab Comparat Immunol,Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis,Res Inst, Boston, MA 02115 USA. [Narendra, Derek P.] Harvard Univ, Sch Med, Neurol Residency Program, Brigham & Womens Hosp, Boston, MA 02115 USA. [Narendra, Derek P.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Notomi, Shoji; Vavvas, Demetrios G.] Harvard Univ, Sch Med, Ophthalmol, Boston, MA 02115 USA. [Airoldi, Edoardo M.] Harvard Univ, Dept Stat, Cambridge, MA 02138 USA. [Yuan, Zhi-Min] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA. [Sarrias, Maria Rosa] Hlth Res Inst Germans Trias Pujol, Badalona, Spain. [Abeliovich, Hagai] Hebrew Univ Jerusalem, Fac Agr Food & Environm Biochem & Food Sci, IL-76100 Rehovot, Israel. [Rasse, Tobias M.] Heidelberg Univ, Deutsch Krebsforschungszentrum, Proteostasis Neurodegenerat Dis B180, CHS Res Grp CellNetworks, Heidelberg, Germany. [Schuck, Sebastian] Heidelberg Univ, Zentrum Mol Biol Univ Heidelberg ZMBH, Heidelberg, Germany. [Ventura, Natascia] Univ Dusseldorf, Inst Clin Chem, Dusseldorf, Germany. [Ventura, Natascia] Diagnost Lab, Fac Med, Dusseldorf, Germany. [Willbold, Dieter] Univ Dusseldorf, Inst Phys Biol, Dusseldorf, Germany. [Stork, Bjoern] Univ Dusseldorf, Inst Mol Med, Dusseldorf, Germany. [Schmitz, Ingo] Helmholtz Ctr Infect Res, Syst Oriented Immunol & Inflammat Res, Braunschweig, Germany. [Korhonen, Laura] Univ Helsinki, Cent Hosp, Fac Med, Div Child Psychiat, Helsinki, Finland. [Screen, Mark] Univ Helsinki, Dept Med Genet, Helsinki, Finland. [Zhou, Guang-Zhou] Henan Univ Technol, Coll Bioengn, Zhengzhou 450000, Henan Province, Peoples R China. [Tanji, Kunikazu] Hirosaki Univ, Grad Sch Med, Hirosaki, Aomori, Japan. [Yamada, Takahiro] Hokkaido Univ, Grad Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido, Japan. [Kihara, Akio] Hokkaido Univ, Fac Pharmaceut Sci, Kita 12, Sapporo, Hokkaido 060, Japan. [Ubukata, Makoto] Hokkaido Univ, Res Fac Agr, Sapporo, Hokkaido, Japan. [Li, Min; Song, Ju-Xian] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China. [Law, Helen Ka-wai; Siu, Parco M.] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China. [Ip, Nancy Y.] Hong Kong Univ Sci & Technol, Kowloon, Hong Kong, Peoples R China. [Rautou, Pierre-Emmanuel] Hop Beaujon, Paris, France. [Kroemer, Guido] Hop Europeen Georges Pompidou, AP HP, Paris, France. [Cerella, Claudia; Radogna, Flavia] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, Luxembourg, Luxembourg. [Lemoine, Antoinette] Hop Univ Paris Sud Biochim & Oncogenet, Hop Paul Brousse, Villejuif, France. [Brumell, John H.] Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada. [Mena, Maria A.] Hosp Univ Ramon Cajal, CIBERNED, Dept Neurobiol, Madrid, Spain. [Frigo, Daniel E.] Houston Methodist Res Inst, Genom Med Program, Houston, TX USA. [Kang, Chanhee] Howard Hughes Med Inst, Boston, MA 02115 USA. [Levine, Beth] Howard Hughes Med Inst, Dallas, TX USA. [Yan, Xianghua] Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan, Hubei, Peoples R China. [Jiang, Yongjun; Liu, Xueqin] Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan, Peoples R China. [Liu, Zexian; Xue, Yu] Huazhong Univ Sci & Technol, Dept Biomed Engn, Coll Life Sci & Technol, Wuhan 430074, Hubei, Peoples R China. [Kaparakis-Liaskos, Maria] Ctr Innate Immun & Infect Dis, Hudson Inst Med Res, Melbourne, Vic, Australia. [Shen, Chiung-Chyi] Hungkuang Univ, Dept Phys Therapy, Taichung, Taiwan. [Aranda, Agustin] Inst Agrochem & Food Technol, IATA CSIC, Paterna, Valencia, Spain. [Menezes, Regina; dos Santos, Claudia Nunes] Inst Biol Expt & Tecnol, iBET, Oeiras, Portugal. [Huang, Yong] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA. [Cederbaum, Arthur I.] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA. [Gandy, Sam] Icahn Sch Med Mt Sinai, Dept Neurol, Ctr Cognit Hlth, Mt Sinai Alzheimers Dis Res Ctr, New York, NY 10029 USA. [Gandy, Sam] Icahn Sch Med Mt Sinai, Dept Psychiat, Ctr Cognit Hlth, Mt Sinai Alzheimers Dis Res Ctr, New York, NY 10029 USA. [Yue, Zhenyu] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA. [Wu, Defeng] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Le Cam, Laurent] Inst Rech Cancerol Montpellier, ICM, Montpellier, France. [Pujol, Aurora] ICREA Catalan Inst Res & Adv Studies, Catalonia, Spain. [Vaccari, Thomas] FIRC Inst Mol Oncol, IFOM, Milan, Italy. [Sonawane, Avinash] IIT Univ, Sch Biotechnol, Bhubaneswar, Orissa, India. [Barreiro, Esther] Pompeu Fabra Univ, Barcelona Biomed Res Pk, Dept Resp Med, Lung Canc & Muscle Res Grp,IMIM Hosp Mar CIBERES, Barcelona, Spain. [Thurston, Teresa L. M.] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Mol Bacteriol & Infect, London, England. [Braga, Vania M. M.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England. [de Belleroche, Jackie] Univ London Imperial Coll Sci Technol & Med, Neurogenet Grp, Div Brain Sci, London, England. [Mostowy, Serge] Univ London Imperial Coll Sci Technol & Med, Microbiol Sect, MRC Ctr Mol Bacteriol & Infect, London, England. [Lee, Michael] Incheon Natl Univ, Div Life Siences, Inchon, South Korea. [Balaji, Kithiganahalli Narayanaswamy] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India. [Somasundaram, Kumaravel] Indian Inst Sci Microbiol & Cell Biol, Bangalore, Karnataka, India. [Dubey, Vikash Kumar] Indian Inst Technol, Dept Biosci & Bioengn, Gauhati, Assam, India. [Maiti, Tapas K.] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India. [Justice, Matthew J.] Indiana Univ Sch Med, Biochem & Mol Biol, Denver, CO USA. [Dong, X. Charlie; Roach, Peter J.] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA. [Naidu, Samisubbu R.] Indiana Univ Sch Med, Dept Dermatol, Indianapolis, IN 46202 USA. [Broxmeyer, Hal E.] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA. [Boulton, Michael E.] Indiana Univ Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA. [Khambu, Bilon; Yin, Xiao-Ming] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA. [Lahm, Tim] Indiana Univ Sch Med, Richard L Roudebush VA Med Ctr, Div Pulm, Crit Care Sleep & Occupat Med, Indianapolis, IN 46202 USA. [Hong, Yonggeun] Inje Univ, Dept Rehabil Sci, Coll Biomed Sci & Engn, u HARC, Gimhae, South Korea. [Corazzari, Marco] INMI IRCCS L Spallanzani, Rome, Italy. [Bruhat, Alain] Ctr Clermont Theix, INRA, Nutr Humaine UMR 1019, St Genes Champanelle, France. [Favier, Francois B.] INRA, Dynam Musculaire & Metab UMR866, F-34060 Montpellier, France. [Seiliez, Iban] INRA, UR1067, Nutr Metab Aquaculture, St Pee Sur Nivelle, France. [Luciano, Federic] INSERM, U1065, C3M, Team 2, Nice, France. [Belaid, Amine; Brest, Patrick; Mograbi, Baharia] IRCAN, INSERM, U1081, CNRS UMR7284, Nice, France. [Giuliano, Sandy] Ctr Sci Monaco, Biomed Dept, Monaco, Monaco. [Giuliano, Sandy; Pages, Gilles] Univ Nice Sophia Antipolis, Inst Res Canc & Ageing Nice, CNRS UMR 7284, INSERM U1081, F-06189 Nice, France. [Dupuis, Luc] INSERM, U1118, Mecanismes Cent & Periphet Neurodegenerescence, Strasbourg, France. [Kepp, Oliver; Torriglia, Alicia] INSERM, U1138, Paris, France. [Pallet, Nicolas] INSERM, U1147, Paris, France. [Mechta-Grigoriou, Fatima] Inst Curie, INSERM U830, Stress & Canc Lab, Paris, France. [Benard, Giovanni] INSERM U862, Neuroctr Magendie, Bordeaux, France. [Le Cam, Laurent] INSERM U896, Montpellier, France. [Duran, Raul V.; Villar, Victor H.] Univ Bordeaux, INSERM U916, Inst Europeen Chim & Biol, Pessac, France. [Teixeira-Clerc, Fatima] INSERM U955, Fac Med Creteil, UMR S955, Creteil, France. [Laporte, Jocelyn; Nicot, Anne-Sophie] Univ Strasbourg, INSERM U964, CNRS UMR7104, Dept Translat Med,IGBMC, Illkirch Graffenstaden, France. [Andrieu-Abadie, Nathalie] Ctr Rech Cancerol Toulouse, INSERM UMR1037, Toulouse, France. [Dugail, Isabelle] INSERM UMRS 1166, Unite Rech Malad Cardiovasc Metab & Nutr, Paris, France. [Kroemer, Guido] INSERM, Cordeliers Res Canc, Paris, France. [Bulavin, Dmitry V.] INSERM, UMR CNRS 7284 U1081, Nice, France. [Gatti, Evelina; Pierre, Philippe] INSERM, U1104, Marseille, France. [Corti, Olga] INSERM, U1127, CNRS, UMR 7225, Paris, France. [Bravo-San Pedro, Jose M.; Galluzzi, Lorenzo; Izzo, Valentina; Pietrocola, Federico; Sica, Valentina] INSERM, U1138, Paris, France. [Rautou, Pierre-Emmanuel] INSERM, U970, Paris, France. [Roue, Gael] IDIBAPS, Hemato Oncol Dept, Barcelona, Spain. [Francois, Aurelie] Inst Cancerol Lorraine, Vandoeuvre Les Nancy, France. [Le Cam, Laurent] Inst Canc Montpellier, Montpellier, France. [Fiorito, Filomena] Ist Zooprofilattico Sperimentale Mezzogio, Dept Chem, Naples, Italy. [Echard, Arnaud] Inst Pasteur, CNRS URA2582, Cell Biol & Infect Dept, Membrane Traff & Cell Div Lab, Paris, France. [Lafont, Frank] Univ Lille, Ctr Infect & Immun Lille, Inst Pasteur Lille, CNRS,INSERM,Lille Reg Univ Hosp Ctr, Lille, France. [Colucci-Guyon, Emma] Inst Pasteur, CNRS, URA2578, Unite Macrophages & Dev Immunite,Dept Biol Dev &, Paris, France. [Albert, Matthew L.] Inst Pasteur, Dept Immunol, Paris, France. [Lecuit, Marc] Inst Pasteur, INSERM, Biol Infect Unit, Paris, France. [Papackova, Zuzana] Inst Clin & Expt Med, Ctr Med Expt, Dept Metab & Diabet, Prague, Czech Republic. [Bianchi, Michele Wolfe] Univ Paris Saclay, Inst Integrat Biol Cell, Gif Sur Yvette, France. [Zorzano, Antonio] Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain. [Triola, Gemma] Spanish Res Council IQAC CSIC, Inst Adv Chem Catalonia, Dept Biomed Chem, Barcelona, Spain. [Ryabovol, Victoria] Inst Biochem & Biophys, Kazan, Russia. [Almonte-Beceril, Maylin] Inst Biomed Invest INIBIC, Inflamat & Regenerat Med, Coruna, Spain. [Jones, Chris] Inst Canc Res, Div Mol Pathol & Canc Therapeut, London SW3 6JB, England. [Zhivotovsky, Boris] Karolinska Inst, Inst Environm Med, Div Toxicol, Stockholm, Sweden. [Chauhan, Santosh] Inst Life Sci, Bhubaneswar, Odisa, India. [Ishaq, Mohammad] Inst Microbial Technol IMTECH, Cell Biol & Immunol Div, Chandigarh, India. [Vachova, Libuse] Inst Microbiol ASCR, Vvi, Prague, Czech Republic. [Penninger, Josef M.] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1010 Vienna, Austria. [Scovassi, A. Ivana] CNR, Inst Mol Genet, Pavia, Italy. [Stulik, Jiri] FMHS UO, Inst Mol Pathol & Biol, Hradec Kralove, Czech Republic. [Stepkowski, Tomasz M.] Ctr Radiobiol & Biol Dosimetry, Inst Nucl Chem & Technol, Dorodna, Poland. [Vescovi, Eleonora Garcia] Inst Biol Mol & Celular Rosario IBR CONICET, Rosario, Argentina. [Lazo, Pedro A.] Hosp Univ Salamanca, Inst Invest Biomed Salamanca IBSAL, Salamanca, Spain. [Martin-Sanz, Paloma] Ctr Invest Biomed Red Enfermedade Hepat & Digest, Inst Invest Biomed Albert Sols, CSIC UAM, Madrid, Spain. [Valverde, Angela M.] CSIC UAM, Inst Invest Biomed Albert Sols, Madrid, Spain. [Fernandez-Checa, Jose C.] CSIC IDI BAPS, Inst Invest Biomed Barcelona, Barcelona, Spain. [Fernandez-Checa, Jose C.] CIBEREHD, ISCIII, Ctr Invest Red Enfermedades Hepat & Digest, Barcelona, Spain. [Oliver, F. Javier] CSIC, IPBLN, Granada, Spain. [Menezes, Regina; dos Santos, Claudia Nunes] Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, P-2780156 Oeiras, Portugal. [Moita, Luis Ferreira] Inst Gulbenkian Ciencias, Oeiras, Portugal. [Garcia-Ruiz, Carmen] Hosp Clin Barcelona IDIBAPS, Inst Invest Biomed Barcelona IIBB CSIC, Liver Unit, Barcelona, Spain. [Garcia-Ruiz, Carmen] CIBEREHD, Barcelona, Spain. [Wappner, Pablo] Inst Leloir, Buenos Aires, DF, Argentina. [Alonso, Covadonga; Galindo, Inmaculada; Munoz-Moreno, Raquel] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotecnol, Madrid, Spain. [Perez-de la Cruz, Veronica] Inst Nacl Neurol & Neurocirug, Neurochem Unit, Mexico City, DF, Mexico. [Pineda, Benjamin] Inst Nacl Neurol & Neurocirug, Neuroimmunol & Neuro Oncol Unit, Mexico City, DF, Mexico. [Menna-Barreto, Rubem F. S.] Fiocruz MS, Inst Oswaldo Cruz, Lab Biol Celular, BR-21045900 Rio De Janeiro, Brazil. [Chandra, Pallavi; Kumar, Dhiraj] Int Ctr Genet Engn & Biotechnol, Immunol Grp, New Delhi, India. [Kanthasamy, Anumantha G.] Iowa State Univ, Dept Biomed Sci, Iowa Ctr Adv Neurotoxicl, Ames, IA USA. [Bassham, Diane C.] Iowa State Univ, Dept Genet Dev & Cell Biol, Ames, IA USA. [MacIntosh, Gustavo C.] Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, Ames, IA USA. [Fusco, Carmela; Merla, Giuseppe; Micale, Lucia] IRCCS Casa Sollievo Sofferenza, Med Genet Unit, San Giovanni Rotondo, FG, Italy. [Fornai, Francesco; Sciarretta, Sebastiano] IRCCS Neuromed, Pozzilli, IS, Italy. [Ferraro, Elisabetta] IRCCS San Raffaele Pisana, Lab Skeletal Muscle Dev & Metab, Rome, Italy. [Cecconi, Francesco; D'Amelio, Marcello; Molinari, Marco; Viscomi, Maria Teresa] IRCCS Santa Lucia Fdn, Rome, Italy. [Campello, Silvia] IRCCS Santa Lucia Fdn, Dept Expt Neurosci, Rome, Italy. [Crippa, Valeria] IRCCS C Mondino Natl Neurol Inst, Expt Neurobiol Lab, Pavia, Italy. [Facchiano, Antonio] IRCCS, Ist Dermopatico Immacolata, Rome, Italy. [Cantoni, Lavinia] IRCCS Ist Ric Farmacol Mario Negri, Dept Mol Biochem & Pharmacol, Milan, Italy. [Albani, Diego] IRCCS Ist Ric Farmacol Mario Negri, Dept Neurosci, Milan, Italy. [Matarese, Giuseppe] IRCCS MultiMed, Milan, Italy. [Marin, Concepcio] Inst Invest Biomed August Pi & Sunyer IDIBAPS, IRCE, Barcelona, Spain. [Gongora, Celine] INSERM, IRCM, Inst Rech Cancerol Montpellier, U896, Montpellier, France. [Pattingre, Sophie] IRCM, Inst Rech Cancerol Montpellier, Montpellier, France. [Cottet, Sandra; Schorderet, Daniel F.] IRO, Inst Res Ophthalmol, Sion, Switzerland. [Chiariello, Mario; Colecchia, David] Ist Fisiol Clin, Siena, Italy. [Bachetti, Tiziana; Ceccherini, Isabella] UOC Med Genet, Ist Giannina Gaslini, Genoa, Italy. [Grimaldi, Benedetto] Ist Italiano Tecnol, Dept Drug Discovery & Dev, Lab Mol Med, Genoa, Italy. [Giovannetti, Elisa] Univ Pisa, AIRC Start UP Unit, Canc Pharmacol Lab, Pisa, Italy. [Merlini, Luciano] Ist Ortopedico Rizzoli IOR IRCCS, Lab Musculoskeletal Cell Biol, Bologna, Italy. [Ortona, Elena; Pierdominici, Marina] Ist Super Sanita, Dept Cell Biol & Neurosci, Viale Regina Elena 299, I-00161 Rome, Italy. [Salvioli, Rosa] Ist Super Sanita, Dept Haematol Oncol & Mol Med, Viale Regina Elena 299, I-00161 Rome, Italy. [Coccia, Eliana M.] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, Viale Regina Elena 299, I-00161 Rome, Italy. [Matarrese, Paola] Ist Super Sanita, Dept Therapeut Res & Med, Evaluat Sect Cell Aging Degenerat & Gender Med, Viale Regina Elena 299, I-00161 Rome, Italy. [Giammarioli, Anna Maria; Malorni, Walter] Ist Super Sanita, Viale Regina Elena 299, I-00161 Rome, Italy. [Chiariello, Mario; Colecchia, David] Ist Toscano Tumori, Siena, Italy. [Condello, Maria; Meschini, Stefania] Italian Natl Inst Hlth, Dept Technol & Hlth, Rome, Italy. [Schiavi, Alfonso; Ventura, Natascia] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany. [Stoka, Veronika; Turk, Boris; Turk, Vito] Jozef Stefan Inst, Dept Biochem & Mol & Struct Biol, Ljubljana, Slovenia. [Karmakar, Parimal] Jadavpur Univ, Life Sci & Biotechnol, Kolkata, W Bengal, India. [Gandy, Sam] James J Peters VA Med Ctr, Bronx, NY USA. [Saran, Shweta] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India. [Platanias, Leonidas C.] Jesse Brown VA Med Ctr, Dept Med, Chicago, IL USA. [Song, Wei] McGill Univ, Jewish Gen Hosp, Bloomfield Ctr Res Aging, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada. [Schipper, Hyman M.] McGill Univ, Jewish Gen Hosp, Dept Neurol & Neurosurg, Dept Med, Montreal, PQ H3T 1E2, Canada. [Topisirovic, Ivan] McGill Univ, Jewish Gen Hosp, Dept Oncol, Montreal, PQ H3T 1E2, Canada. [Yu, Huixin; Zhang, Li] Jiangsu Inst Nucl Med, Wuxi, Jiangsu, Peoples R China. [Su, Zhaoliang] Jiangsu Univ, Dept Immunol, Zhenjiang, Jiangsu, Peoples R China. [Guo, Wenjie] Jiangsu Univ, Sch Pharm, Zhenjiang, Jiangsu, Peoples R China. 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[Kominami, Eiki] Juntendo Univ, Tokyo, Japan. [Hasui, Kazuhisa] Kagoshima Univ, Grad Sch Med & Dent Sci, Div Human Pathol, Dept Oncol,Course Adv Therapeut, Kagoshima 890, Japan. [Setoguchi, Takao] Kagoshima Univ, Near Future Locomoter Organ Med Creat Course, Grad Sch Med & Dent Sci, Kagoshima 890, Japan. [Lee, Gyun Min] Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejon, South Korea. [Okazaki, Toshiro] Kanazawa Med Univ, Dept Med, Kanazawa, Ishikawa, Japan. [Koya, Daisuke] Kanazawa Med Univ, Diabetol & Endocrinol, Kanazawa, Ishikawa, Japan. [Sasaki, Motoko] Kanazawa Univ, Grad Sch Med Sci, Dept Human Pathol, Kanazawa, Ishikawa, Japan. [Wong, Richard W.] Kanagawa Univ, Cell Bion Unit, Dept Biol, Fac Nat Syst,Inst Sci & Engn, Kanagawa, Ishikawa, Japan. [Wong, Richard W.] Kanagawa Univ, Lab Mol & Cellular Biol, Dept Biol, Fac Nat Syst,Inst Sci & Engn, Kanagawa, Ishikawa, Japan. [Lee, Stella Y.; Roelofs, Jeroen] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. 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[Takigawa, Nagio] Kawasaki Med Univ, Dept Gen Internal Med 4, Okayama, Japan. [Hino, Keisuke] Kawasaki Med Univ, Dept Hepatol & Pancreatol, Kurashiki, Okayama, Japan. [Kwon, Taeg Kyu] Keimyung Univ, Daegu, South Korea. [Jang, Byoung Kuk] Keimyung Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Daegu, South Korea. [Ishii, Isao] Keio Univ, Grad Sch Pharmaceut Sci, Dept Biochem, Tokyo, Japan. [Suzuki, Hidekazu] Keio Univ, Sch Med, Med Educ Ctr, Tokyo, Japan. [Alloza, Iraide] Basque Fdn Sci, KERBASQUE, Bilbao, Spain. [Harrath, Abdel Halim] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia. [Otsu, Kinya] Kings Coll London, Cardiovasc Div, London WC2R 2LS, England. [Fanto, Manolis; Jungbluth, Heinz] Kings Coll London, Dept Basic & Clin Neurosci, IoPPN, London WC2R 2LS, England. [Jungbluth, Heinz] Kings Coll London, Randall Div Cell & Mol Biophys, Muscle Signalling Sect, London, England. [Shintani, Michiko] Kobe Univ, Grad Sch Hlth Sci, Pathol Lab, Div Med Biophys, Kobe, Hyogo, Japan. [Matsushita, Takehiko] Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Kobe, Hyogo, Japan. [Voitsekhovskaja, Olga V.] Komarov Bot Inst RAS, Plant Ecol Physiol Lab, St Petersburg, Russia. [Cho, Ssang-Goo] Konkuk Univ, Dept Anim Biotechnol, Seoul, South Korea. [Lim, Hyunjung Jade] Konkuk Univ, Dept Vet Med, Seoul, South Korea. [Chung, Hyewon] Konkuk Univ, Sch Med, Dept Ophthalmol, Seoul, South Korea. [Lee, He-Jin] Konkuk Univ, Sch Med, Dept Anat, Seoul, South Korea. [Kim, Cheol Hyeon] Korea Canc Ctr Hosp, Dept Internal Med, Seoul, South Korea. [Lee, Sung-Joon] Korea Univ, Dept Biotechnol, PLUS Grad Sch Life Sci & Biotechnol BK21, Seoul, South Korea. [Chi, Sung-Gil; Choi, Eui-Ju; Lee, Jae Keun; Wright, Karen L.] Korea Univ, Dept Life Sci & Biotechnol, Seoul, South Korea. [Chun, Taehoon] Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul, South Korea. [Park, Ohkmae K.; Song, Hyun Kyu] Korea Univ, Div Life Sci, Seoul, South Korea. [Van Den Bosch, Ludo] Katholieke Univ Leuven, Leuven, Belgium. [Van Den Bosch, Ludo] VIB, Vesalius Res Ctr, Neurobiol Lab, Leuven, Belgium. [Gunst, Jan; Van den Berghe, Greet; Vanhorebeek, Ilse] Katholieke Univ Leuven, Clin Div, Leuven, Belgium. [Gunst, Jan; Van den Berghe, Greet; Vanhorebeek, Ilse] Lab Intens Care Med, Dept Cellular & Mol Med, Leuven, Belgium. [Decuypere, Jean-Paul] Katholieke Univ Leuven, Dept Abdominal Transplant Surg, Leuven, Belgium. [Martin, Shaun] Katholieke Univ Leuven, Dept Cellular & Mol Med, Leuven, Belgium. [Soenen, Stefaan J.] Katholieke Univ Leuven, Dept Imaging & Pathol, Leuven, Belgium. [Agostinis, Patrizia; Maes, Hannelore] Katholieke Univ Leuven, Lab Cell Death Res & Therapy, Dept Cellular & Mol Med, Campus Gasthuisberg, Leuven, Belgium. [Bultynck, Geert; Parys, Jan B.] Katholieke Univ Leuven, Lab Mol & Cellular Signaling, Dept Cellular & Mol Med, Leuven, Belgium. [Ohmuraya, Masaki] Kumamoto Univ, Inst Resource Dev & Anal, Kumamoto, Japan. [Agam, Galila] Kunming Univ Sci & Technol, Sch Med, Kunmimg, Yunnan, Peoples R China. [Tanaka, Masaki; Watanabe, Yoshihisa] Kyoto Prefectural Univ Med, Dept Basic Geriatr, Kyoto, Japan. [Matoba, Satoaki] Kyoto Prefectural Univ Med, Dept Cardiovasc Med, Grad Sch Med Sci, Kyoto, Japan. [Nagata, Kazuhiro] Kyoto Sangyo Univ, Dept Life Sci, Kyoto 603, Japan. [Ushioda, Ryo] Kyoto Sangyo Univ, Dept Mol Biosci, Fac Life Sci, Kyoto 603, Japan. [Goto-Yamada, Shino] Kyoto Univ, Dept Bot, Kyoto, Japan. [Shioi, Tetsuo] Kyoto Univ, Dept Cardiovasc Med, Kyoto, Japan. [Asanuma, Katsuhiko] Kyoto Univ, Grad Sch Med, Med Innocat Ctr TMK Project, Kyoto, Japan. [Cho, Dong-Hyung] Kyung Hee Univ, Grad Sch East Wast Med Sci, Seoul, South Korea. [Bae, Jae-Sung] Kyungpook Natl Univ, Dept Physiol, Sch Med, Daegu, South Korea. [Shirabe, Ken] Kyushu Univ, Dept Surg & Sci, Fukuoka 812, Japan. [Fairlie, W. Douglas; Lee, Erinna F.] Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia. [Soo, Kai Y.] La Trobe Univ, Dept Biochem & Genet, La Trobe Inst Mol Sci, Melbourne, Vic, Australia. [Fairlie, W. Douglas; Lee, Erinna F.] La Trobe Univ, Dept Chem & Phys, Melbourne, Vic, Australia. [Fairlie, W. Douglas; Lee, Erinna F.] La Trobe Univ, Sch Canc Med, Melbourne, Vic, Australia. [Paganetti, Paolo] Neurodegenerat Grp, Lab Biomed Neurosci NSI EOC, Torricella Taverne, Switzerland. [Nilsson, Per] RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama, Japan. [Choi, Eun-Kyoung] Ilsong Inst Life Sci, Lab Cellular Aging & Neurodegenerat, Anyang, Gyeonggi Do, South Korea. [Mayer, Andreas] Univ Lancaster, Fac Hlth & Med, Div Biomed & Life Sci, Lancaster, England. [Erenpreisa, Jekaterina] Latvian Biomed Res & Study Ctr, Riga, Latvia. [Spaink, Herman P.] Leiden Univ, Inst Biol, Leiden, Netherlands. [Stern, Stephan T.] Leidos Biomedical Res Inc, Frederick Natl Lab Canc Res, Nanotechnol Characterizat Lab, Canc Res Technol Program, Frederick, MD USA. [Los, Marek] Med Univ Silesia, ENT Dept, Sch Med, Katowice, Poland. [Kagedal, Katarina; Mohseni, Simin; Ollinger, Karin] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden. [Kurz, Tino] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden. [Boman, Andrea] Linkoping Univ, Expt Pathol, Dept Clin & Expt Med, Fac Hlth Sci, Linkoping, Sweden. [Taylor, Mark J.] Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England. [Shajahan-Haq, Ayesha N.] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA. [Zhivotovsky, Boris] Lomonosov Moscow State Univ, Fac Basic Med, Moscow, Russia. [Tooze, Sharon A.] Canc Res UK, London Res Inst, London, England. [Swanton, Charles] UCL, Inst Canc, London, England. [Rihn, Bertrand H.] Lorraine Univ, CITHeFOR EA3452, Fac Pharm, Nancy, France. [Adler, Sharon G.] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA. [Huang, Shile] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA. [Wu, Chunlai] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 71105 USA. [Lin, Yong] Lovelace Resp Res Inst, Mol Biol & Lung Canc Program, Albuquerque, NM USA. [von Schwarzenberg, Karin] Univ Munich, Dept Pharm, Munich, Germany. [Swaerd, Karl] Lund Univ, Biomed Ctr, Dept Expt Med Sci, Lund, Sweden. [Berchem, Guy] Luxembourg Inst Hlth, Luxembourg, Luxembourg. [Berchem, Guy] Ctr Hosp Luxembourg, Luxembourg, Luxembourg. [Janji, Bassam] Luxembourg Inst Hlth, Lab Expt Hemato Oncol, Dept Oncol, Luxembourg, Luxembourg. [El-Khoury, Victoria] Luxembourg Inst Hlth, Dept Oncol, Luxembourg, Luxembourg. 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[Tan, Mei Lan] Malaysian Inst Pharmaceut & Nutraceuticals, George Town, Malaysia. [Rudolf, Ruediger; Wild, Franziska] Mannheim Univ Appl Sci, Inst Mol & Cell Biol, Mannheim, Germany. [Slaninova, Iva] Masaryk Univ, Dept Biol, Fac Med, Brno, Czech Republic. [Costes, Safia; Mao, Kai] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Costes, Safia] Harvard Univ, Sch Med, Ctr Human Genet Res, Boston, MA USA. [Costes, Safia] Dept Neurol, Boston, MA USA. [Goruppi, Sandro; Lee, Sam W.; Tannous, Bakhos A.] Massachusetts Gen Hosp, Charlestown, MA USA. [Goruppi, Sandro; Lee, Sam W.] Harvard Univ, Sch Med, Cutaneous Biol Res Ctr, Charlestown, MA USA. [Mao, Kai] Harvard Univ, Sch Med, Dept Mol Biol, Dept Genet, Boston, MA 02115 USA. [Tannous, Bakhos A.] Harvard Univ, Sch Med, Expt Therapeut & Mol Imaging Lab, Neurosci Ctr, Charlestown, MA USA. [Vyas, Jatin M.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Amon, Angelika; Santaguida, Stefano] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Graef, Martin; Motori, Elisa] Max Planck Inst Biol Ageing, Cologne, Germany. [Storchova, Zuzana] Max Planck Inst Biochem, Grp Maintenance Genome Stabil, Klopferspitz 18A, D-82152 Martinsried, Germany. [Wollert, Thomas] Max Planck Inst Biochem, Mol Membrane & Organelle Biol, Klopferspitz 18A, D-82152 Martinsried, Germany. [Chowdhury, Kamal] Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany. [Gassen, Nils Christian; Rein, Theo] Max Planck Inst Psychiat, Translat Res Psychiat, Munich, Germany. [Schulze, Ryan J.] Mayo Clin, Dept Biochem, Rochester, MN USA. [Fiesel, Fabienne C.; Springer, Wolfdieter] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA. [Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA. [Sinicrope, Frank A.; Xu, Xiaolei] Mayo Clin, Rochester, MN USA. 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[Campbell, Matthew] Trinity Coll Dublin, Smurfit Inst Genet, Dublin, Ireland. [Chen, Ye-Guang; Liu, Yule; Wang, Yan] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China. [Yu, Li] Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Tsing Hua Univ, Peking Univ,Joint Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China. [Lei, Jinzhi] Tsinghua Univ, Zhou Pei Yuan Ctr Appl Math, Beijing 100084, Peoples R China. [Taylor, Allen] Tufts Univ, USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Dash, Srikanta] Tulane Univ, Hlth Sci Ctr, Dept Pathol & Lab Med, New Orleans, LA 70118 USA. [Simak, Jan] US FDA, Ctr Biol Evaluat & Res, Silver Spring, MD USA. [Rao, V. Ashutosh] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA. [Galadari, Sehamuddin] UAE Univ, Cell Signaling Lab, Dept Biochem, Coll Med & Hlth Sci, Abu Dhabi, U Arab Emirates. [Bjedov, Ivana] UCL Canc Inst, London, England. [Salomoni, Paolo] UCL Canc Inst, Samantha Dickson Brain Canc Unit, London, England. [Jacques, Thomas S.] UCL Inst Child Hlth, London, England. [Jacques, Thomas S.] Great Ormond St Hosp Children NHS Fdn Trust, London, England. [Lewis, Patrick A.] UCL Inst Neurol, Dept Mol Neurosci, London, England. [Manzoni, Claudia] UCL Inst Neurol, London, England. [Cheetham, Michael E.] UCL Inst Ophthalmol, London, England. [Guo, Ming] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA. [Linden, Rafael] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio de Janeiro, Brazil. [Simmet, Thomas] Univ Ulm, Inst Pharmacol Nat Cpds & Clin Pharmacol, D-89069 Ulm, Germany. [Carlsson, Sven R.] Umea Univ, Dept Med Biochem & Biophys, Umea, Sweden. [Kaeffer, Bertrand] UMR 1280, Nantes, France. [Manie, Serge N.] CNRS, INSERM 1052, UMR 5286, Canc Res Ctr Lyon, Lyon, France. [Maiuri, Maria Chiara] Ctr Rech Cordeliers, UMRS 1138, Paris, France. [Gorbunov, Nikolai V.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. [Kiang, Juliann G.] Uniformed Serv Univ Hlth Sci, Radiat Combined Injury Program, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. [Ozpolat, Bulent; Scovassi, A. Ivana; Stellrecht, Christine M.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Gonzalez, Carlos B.] Univ Austral Chile, Dept Physiol, Valdivia, Chile. [Diaz-Nido, Javier] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CIBERER, Madrid, Spain. [Gargini, Ricardo] Univ Autonoma Madrid, CNB CSIC, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, Madrid, Spain. [Cuezva, Jose M.] Univ Autonoma Madrid, Dept Biol Mol, Madrid, Spain. [Magarinos, Marta] Univ Autonoma Madrid, Dept Biol, Madrid, Spain. [Guillen, Carlos] Univ Complutense, Sch Pharm, E-28040 Madrid, Spain. [Guillen, Carlos] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Olicas Asociada, Madrid, Spain. [Papademetrio, Daniela L.] Univ Buenos Aires, Inmunol, Fac Farm & Bioquim, Buenos Aires, DF, Argentina. [Cena, Valentin] Univ Castilla La Mancha, Albacete, Spain. [Jordan, Joaquin] Univ Castilla La Mancha, Fac Med, Dept Ciencias Med, Albacete, Spain. [Sanchez-Prieto, Ricardo] Univ Castilla La Mancha, Lab Oncol Mol, Ctr Reg Invest Biomed, Albacete, Spain. [Troncoso, Rodrigo] Univ Chile, Adv Ctr Chron Dis ACCDiS, Fac Ciencias Quim & Farmaceut, Santiago, Chile. [Chiong, Mario; Criollo, Alfredo; Lavandero, Sergio] Univ Chile, Adv Ctr Chron Dis ACCDiS, Santiago, Chile. [Diaz-Araya, Guillermo] Univ Chile, Fac Ciencias Quim & Farmaceut, Santiago, Chile. [Glavic, Alvaro] Univ Chile, Fac Ciencias, Dept Biol, Ctr Regulac Genoma, Santiago, Chile. [Troncoso, Rodrigo] Univ Chile, INTA, Santiago, Chile. [Corral-Ramos, Cristina; Di Pietro, Antonio; Roncero, M. Isabel G.; Ruiz-Roldan, Carmen] Univ Cordoba, Campus Excelencia Agroalimentario CeiA3, Dept Genet, Cordoba, Spain. [Mora-Rodriguez, Rodrigo] Univ Costa Rica, CIET, San Jose, Costa Rica. [Fuentes, Jose M.; Gomez-Sanchez, Ruben; Ana Gonzalez-Polo, Rosa; Niso-Santano, Mireia] Univ Extremadura, CIBERNED, Dept Bioquim & Biol Mol & Genent, Fac Enfermeria & Terapia Ocupac, Caceres, Spain. [Fernandez-Lopez, Arsenio; Perez-Rodriguez, Diego] Univ Leon, Area Biol Celular, Inst Biomed, E-24071 Leon, Spain. [Fernandez-Barrena, Maite G.] Univ Navarra, Ctr Invest Med Aplicada, E-31080 Pamplona, Spain. [Albaiceta, Guillermo M.] Univ Oviedo, Dept Biol Func, Oviedo, Spain. [Fernandez, Alvaro F.; Lopez-Otin, Carlos] Univ Oviedo, Inst Univ Oncol, Dept Bioquim & Biol Mol, Oviedo, Spain. [Jimenez, Alberto] Univ Salamanca, Dept Microbiol & Genet, Campus Miguel Unamuno, E-37008 Salamanca, Spain. [Boada-Romero, Emilio; Pimentel-Muinos, Felipe X.] Univ Salamanca, IBMCC, Ctr Invest Canc, Campus Unamuno, Salamanca, Spain. [Miranda-Vizuete, Antonio] Univ Seville, Inst Biomed Sevilla, Hosp Univ Virgen Rocio, Consejo Super Invest Cient, Seville, Spain. [Ruano, Diego] Univ Seville, Inst Biomed Sevilla, Seville, Spain. [Crespo, Jose L.; Esther Perez-Perez, Maria] Univ Seville, CSIC, Inst Bioquim Vegetal & Fotosintesis, Seville, Spain. [Couve, Eduardo] Univ Valparaiso, Inst Biol, Fac Ciencias, Valparaiso, Chile. [Pardo, Julian] Univ Zaragoza Araid, IIS Aragon, Ctr Invest Biomed Aragon, Zaragoza, Spain. [Filippi-Chiela, Eduardo C.; Lenz, Guido; Thome, Marcos P.] Univ Fed Rio Grande do Sul, Dept Biophys, Porto Alegre, RS, Brazil. [Filippi-Chiela, Eduardo C.; Lenz, Guido; Thome, Marcos P.] Ctr Biotechnol, Porto Alegre, RS, Brazil. [Silvia Romano, Patricia] Univ Nacl Cuyo FCM UNCUYO, Inst Histol & Embriol IHEM CONICET, Fac Ciencias Med, Mendoza, Argentina. [Sanchez-Alcazar, Jose A.] Univ Pablo Olavide, CABD, Consejo Super Invest Cient Junta Andalucia, Seville, Spain. [Weis, Simone Nardin] Univ Brasilia, Dept Biol Celular, Brasilia, DF, Brazil. [Rodrigues, Cecilia M. P.] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Lisbon, Portugal. [Botana, Luis M.] Univ Santiago Compostela, Dept Farmacol, Fac Vet, Lugo, Spain. [Goldman, Gustavo H.] Univ Sao Paulo, FCFRP, USP, Sao Paulo, Brazil. [Hernandez, Agustin] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, Sao Paulo, Brazil. [Brito, Glauber C.] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Fac Med, Sao Paulo, SP, Brazil. [Tenorio de Melo, Edesio Jose] Univ Estadual Norte Fluminense, Ctr Biociencias Biotecnol, Lab Biol Celular & Tecidual, Setor Toxicol Celular, Campos Goytacazes, Rio De Janeiro, Brazil. [Rizzo, Elizete] Univ Fed Minas Gerais, Dept Morfol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil. [Bincoletto, Claudia] Univ Fed Sao Paulo UNIFESP, Dept Farmacol, Escola Paulista Med, Sao Paulo, SP, Brazil. [Vieira, Helena L. A.] Univ Nova Lisboa, CEDOC, NOVA Med Sch, Lisbon, Portugal. [Revuelta, Jose L.] Univ Salamanca, Dept Microbiol & Genet, Campus Miguel Unamuno, E-37008 Salamanca, Spain. [Poletti, Angelo; Rusmini, Paola] Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy. [Carra, Serena] Univ Modena & Reggio Emilia, Dipartimento Sci Biomed Metab & Neurosci, Modena, Italy. [Follo, Carlo; Isidoro, Ciro] Univ Piemonte Orientale, Dipartimento Sci Salute, Novara, Italy. [Genazzani, Armando A.] Univ Piemonte Orientale, Novara, Italy. [Matarese, Giuseppe] Univ Salerno, Dipartimento Med & Chirurg, I-84100 Salerno, Italy. [Rippo, Maria Rita] Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy. [Cenci, Simone; Milan, Enrico] Univ Vita Salute San Raffaele, Milan, Italy. [Casas, Caty] Univ Autonoma Barcelona, Dept Cell Biol Physiol & Immunol, Inst Neurociencies, E-08193 Barcelona, Spain. [Ventura, Salvador] Autonomous Univ Barcelona, Inst Biotecnol & Biomed, Bellaterra, Barcelona, Spain. [Ventura, Salvador] Dept Bioquim & Biol Mol, Bellaterra, Barcelona, Spain. [Zorzano, Antonio] Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, Barcelona, Spain. [Luis Rosa, Jose] Univ Barcelona, Hosp Llobregat, Dept Ciencies Fisiol Giques 2, Inst Invest Biomed Bellvitge IDI BELL, Campus Bellvitge, Barcelona, Spain. [Segui-Simarro, Jose M.] Univ Politecn Valencia, COMAV Inst, E-46022 Valencia, Spain. [Reichert, Andreas S.] Univ Klinikum Dusseldorf, Inst Biochem & Mol Biol 1, Dusseldorf, Germany. [Bouchecareilh, Marion; Priault, Muriel] Univ Bordeaux Segalen, Inst Biochim & Genet Cellulaires, CNRS, UMR 5095, Bordeaux, France. [Pasquet, Jean-Max] Univ Bordeaux Segalen, INSERM U1035, Hematopoiese Leucem & Cibles Therapeut, Bordeaux, France. [Duvezin-Caubet, Stephane] Univ Bordeaux, Inst Biochim & Genet Cellulaires, CNRS, UMR 5095, Bordeaux, France. [Lapaquette, Pierre] Univ Bourgogne Franche Comte, Agrosup Dijon, UMR PAM, Equipe Vin Aliment Microbiol, Dijon, France. [Feron, Olivier] Catholic Univ Louvain, IREC, B-1200 Brussels, Belgium. [Batoko, Henri] Catholic Univ Louvain, Inst Sci Vie, Louvain La Neuve, Belgium. [Deldicque, Louise] Catholic Univ Louvain, Inst Neurosci, Louvain La Neuve, Belgium. [Gailly, Philippe] Catholic Univ Louvain, Lab Cell Physiol, B-1200 Brussels, Belgium. [Bruhat, Alain] Univ Clermont 1, UFR Med, Nutr Humaine UMR1019, Clermont Ferrand, France. [Dalmasso, Guillaume; Darfeuille-Michaud, Arlette; Nguyen, Hang T. T.] Univ Auvergne, M2iSH, INSERM UMR 1071, Ctr Biomed Rech & Valorisat,Fac Med, Clermont Ferrand, France. [Djavaheri-Mergny, Mojgan] Univ Bordeaux, INSERM U916, Inst Bergonie, Bordeaux, France. [Dehay, Benjamin] Univ Bordeaux, Inst Malad Neurodegenerat, CNRS UMR 5293, Bordeaux, France. [Camougrand, Nadine] Univ Bordeaux, CNRS, Inst Biochim & Genet Cellulaires, UMR 5095, Bordeaux, France. [Delage-Mourroux, Regis] Univ Franche Comte, UFR Sci & Tech EA3922, SFR IBCT FED 4234, Estrogenes Express Genique & Pathol Syst Nerveux, Besancon, France. [Boyer-Guittaut, Michaeel] Univ Franche Comte, UFR Sci & Tech, Lab Biochim, Besancon, France. [Verdier, Mireille] Univ Limoges, EA 3842, LHCP, Fac Med, Limoges, France. [Kretz-Remy, Carole] Univ Lyon, Lyon, France. [Kretz-Remy, Carole] Univ Lyon 1, Ctr Genet & Physiol Mol & Cellulaire, F-69622 Villeurbanne, France. [Freyssenet, Damien G.] Univ Lyon, Fac Med, Saint Etienne, France. [Faure, Mathias] Univ Lyon, INSERM, CIRI, Ecole Normale Super Lyon,CNRS,UMR 5308,U 111, Lyon, France. [Mollereau, Bertrand] Univ Lyon, CNRS UMR 5239, Mol Cell Biol Lab, Ecole Normale Super Lyon, Lyon, France. [Besteiro, Sebastien] Univ Montpellier, DIMNP, CNRS, UMR 5235, F-34059 Montpellier, France. [Pattingre, Sophie] Univ Montpellier, Inst Reg Canc Montpellier, INSERM, U 1194, F-34059 Montpellier, France. [Favier, Francois B.] Univ Montpellier, F-34059 Montpellier, France. [Bernard, Monique; Hebert, Marie-Josee] Univ Montreal, Dept Med, Montreal, PQ, Canada. [Pacelli, Consiglia] Univ Montreal, Dept Pharmacol, Fac Med, Montreal, PQ H3C 3J7, Canada. [Burelle, Yan] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada. [Knaevelsrud, Helene] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada. [Vallette, Francois] Univ Nantes, CRCNA, UMRINSERM 892, CNRS 6299, Nantes, France. [Chevet, Eric] Univ Rennes 1, OSS, ERL INSERM 440, Ctr Lutte Canc Eugene Marquis, Rennes, France. [Beaulieu, Jean-Francois; Jean, Steve] Univ Sherbrooke, Dept Anat & Cell Biol, Fac Med & Hlth Sci, Sherbrooke, PQ J1K 2R1, Canada. [Dupuis, Luc] Univ Strasbourg, Fac Med, UMRS 1118, Strasbourg, France. [Gros, Frederic] Univ Strasbourg, CNRS UPR3572, Immunopathol & Chim Therapeut, IBMC, Strasbourg, France. [Barbeau, Benoit] Univ Quebec, Dept Sci Biol, Montreal, PQ H3C 3P8, Canada. [Barbeau, Benoit] Ctr Rech BioMed, Montreal, PQ, Canada. [Taillebourg, Emmanuel] Univ Grenoble Alpes, CEA DSV iRTSV BGE GenandChem, INSERM, U1038, Grenoble, France. [Francois, Arnaud] Univ Laval, Neurosci Axis, Quebec City, PQ, Canada. [Cnop, Miriam] Univ Libre Bruxelles, ULB Ctr Diabet Res, Brussels, Belgium. [Palladino, Francesca] Univ Lyon, Ecole Normale Super Lyon, Lyon, France. [Baghdiguian, Stephen] Univ Montpellier 2, Inst Sci Evolut, CNRS, UMR 5554, Montpellier, Languedoc Rouss, France. [Pierrefite-Carle, Valerie] Univ Nice Sophia Antipolis, UMR MATOs CEA iBEB E 4320TIRO, Fac Med, Nice, France. [Kroemer, Guido] Univ Paris 05, Apoptosis Canc & Immun Lab, Team 11, Equipe Labellisee Ligue Canc & Cell Biol & Met Pl, Paris, France. [Tamburini, Jerome] Univ Paris 05, Inst Cochin, Sorbonne Paris Cite, Fac Med, Paris, France. [Pende, Mario] Univ Paris 05, Inst Necker Enfants Malades, INSERM, U1151, Paris, France. [Rautou, Pierre-Emmanuel] Univ Paris 05, Paris, France. [Bravo-San Pedro, Jose M.; Galluzzi, Lorenzo; Izzo, Valentina; Pietrocola, Federico; Sica, Valentina] Univ Paris Descartes Paris V, Paris, France. [Botti, Joelle; Codogno, Patrice; Dupont, Nicolas; Hamai, Ahmed; Mehrpour, Maryam; Morel, Etienne; Nascimbeni, Anna Chiara; Orhon, Idil] Univ Paris 05, Sorbonne Paris Cite, INEM, INSERM U1151,CNRS UMR 5253, Paris, France. [Ait-Si-Ali, Slimane] Univ Paris 05, Sorbonne Paris Cite, Ctr Epigenet & Destin Cellulaire, CNRS,UMR 7216, Paris, France. [Le Stunff, Herve] Univ Paris 05, Unite Biol Fonctionnelle & Adaptat, CNRS UMR 8251, Paris, France. [Bianchi, Michele Wolfe] Univ Paris Est Creteil, Creteil, France. [Teixeira-Clerc, Fatima] Univ Paris Est, Inst Mondor Rech Biomed, Paris, France. [Le Stunff, Herve; Legouis, Renaud] Univ Paris Sud, CEA, CNRS, Inst Integrat Biol Cell, Gif Sur Yvette, France. [Bianchi, Michele Wolfe] Univ Paris Sud, CEA, CNRS, Paris, France. [Deutsch, Eric] Univ Paris Sud, INSERM 1030, Gustave Roussy Canc Campus, Paris, France. [Dokudovskaya, Svetlana] Univ Paris Sud, Inst Gustave Roussy, CNRS UMR 8126, Villejuif, France. [Wiels, Joelle] Univ Paris Sud, Univ Paris Saclay, CNRS UMR 8126, Inst Gustave Roussy, Villejuif, France. [Tan, Mei Lan] Univ Sains Malaysia, Adv Med & Dent Inst, Minist Sci Technol & Innovat, George Town, Malaysia. [D'Orazi, Gabriella] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy. [Corasaniti, Maria Tiziana] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy. [Isakovic, Aleksandra J.] Univ Belgrade, Sch Med, Belgrade, Serbia. [Lizard, Gerard] Univ Bourgogne Franche Comte, EA 7270, INSERM, Dijon, France. [Fortunato, Franco] Univ Clin Heidelberg, Dept Expt Surg, Heidelberg, Germany. [Rami, Abdelhaq] Univ Clin, Inst Cellular & Mol Anat Anat 3, Frankfurt, Germany. [McKenna, Sharon; O'Donovan, Tracey] Natl Univ Ireland Univ Coll Cork, BioSci Inst Co, Cork Canc Res Ctr, Cork, Ireland. [Waeber, Christian] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Dept Pharmacol & Therapeut, Cork, Ireland. [Al-Rubeai, Mohamed] Univ Coll Dublin, Sch Chem & Bioproc Engn, Dublin 2, Ireland. [Alvarez-Erviti, Lydia; Cooper, J. Mark] UCL, Dept Clin Neurosci, London, England. [Ketteler, Robin; Kriston-Vizi, Janos; Prak, Krisna] UCL, MRC Lab Mol Cell Biol, London, England. [Duchen, Michael R.] UCL, UCL Consortium Mitochondrial Res, London, England. [Duchen, Michael R.] Dept Cell & Dev Biol, London, England. [Clementi, Emilio] Univ Milan, Univ Hosp Luigi Sacco, Clin Pharmacol Unit, Natl Res Council,Inst Neurosci,Dept Biomed & Clin, Milan, Italy. [Strnad, Pavel] Univ Hosp Aachen, IZKF, Aachen, Germany. [Strnad, Pavel] Dept Internal Med III, Aachen, Germany. [Puyal, Julien; Truttmann, Anita C.] Univ Lausanne, Univ Hosp Ctr, Clin Neonatol, Dept Pediat & Pediat Surg, Lausanne, Switzerland. [Bergami, Matteo] Univ Hosp Cologne, CECAD Res Ctr, Cologne, Germany. [Klucken, Jochen; Minakaki, Georgia] Univ Erlangen Nurnberg, Univ Hosp Erlangen, D-91054 Erlangen, Germany. [Hasselblatt, Peter] Univ Hosp Freiburg, Dept Med 2, Freiburg, Germany. [Dahmen, Uta] Univ Hosp Jena, Dept Gen Visceral & Vasc Surg, Expt Transplantat Surg, Jena, Germany. [Bou, German] Univ Hosp La Coruna, Dept Microbiol, La Coruna, Spain. [Pavenstaedt, Hermann] Univ Hosp Muenster, Internal Med D, Dept Nephrol Hypertens & Rheumatol, Albert Schweitzer Campus, Munster, Germany. [Patschan, Daniel] Univ Hosp Gottingen, Dept Nephrol & Rheumatol, Gottingen, Germany. [Duchosal, Michel A.] Univ Hosp Lausanne, Serv & Cent Lab Hematol, Lausanne, Switzerland. [Weide, Thomas] Univ Hosp Muenster, Dept Internal Med D, Mol Nephrol, Munster, Germany. [Schneider, E. Marion] Univ Hosp Ulm, Sekt Expt Anaestesiol, Ulm, Germany. [Scharl, Michael] Univ Hosp Zurich, Div Gastroenterol & Hepatolog, Zurich, Switzerland. [Decuypere, Jean-Paul] Univ Hosp Leuven, Dept Microbiol & Immunol, Lab Abdominal Transplantat, Leuven, Belgium. [Vandenberghe, Wim] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium. [Martinez, Jennifer] Natl Inst Environm Hlth Sci, Immun Inflammat & Dis Lab, Res Triangle Pk, NC USA. [Duez, Helene; Lancel, Steve] Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille,U1011,EGID, Lille, France. [Huber, Tobias B.] Univ Med Ctr Freiburg, Freiburg, Germany. [Vellenga, Edo] Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands. [Galliciotti, Giovanna] Univ Hamburg, Med Ctr, Inst Neuropathol, Hamburg, Germany. [Behl, Christian] Johannes Gutenberg Univ Mainz, Med Ctr, Inst Pathobiochemi, D-55122 Mainz, Germany. [Mari, Muriel; Reggiori, Fulvio] Univ Groningen, Univ Med Ctr Groningen, Dept Cell Biol, Groningen, Netherlands. [Schmidt, Jens] Univ Gottingen, Med Ctr, Clin Neurol, D-37073 Gottingen, Germany. [Schmidt, Jens] Dept Neuroimmunol, Gottingen, Germany. [Outeiro, Tiago F.] Univ Gottingen, Med Ctr, Dept Neurodegenerat & Restorat Res, D-37073 Gottingen, Germany. [Boes, Marianne] Univ Utrecht, Med Ctr, Lab Translat Immunol, Utrecht, Netherlands. [Boes, Marianne] Univ Hosp Children & Youth, Dept Pediat Immunol, Utrecht, Netherlands. [Koch, Jan C.] Univ Med Gottingen, Dept Neurol, Gottingen, Germany. [Wang, Jing] Univ Montpellier I, INSERM U1051, Montpellier, France. [Vidal, Michel] Univ Montpellier, UMR5235, F-34059 Montpellier, France. [Coxon, Fraser P.] Univ Aberdeen, Div Appl Med, Aberdeen, Scotland. [Ganesan, Swamynathan] Univ Adelaide, Alzheimers Dis Genet Lab, Adelaide, SA, Australia. [Richards, Robert I.] Univ Adelaide, Dept Genet & Evolut, Sch Biol Sci, Adelaide, SA, Australia. [Ramanadham, Sasanka] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol CDIB, Comprehens Diabet Ctr UCDC, Birmingham, AL USA. [Xu, Zhi-Xiang] Univ Alabama Birmingham, Dept Med, Div Hematol & Oncol, Ctr Comprehens Canc, Birmingham, AL 35294 USA. [Roth, Kevin A.; Shacka, John J.; Zhang, Jianhua] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Darley-Usmar, Victor M.] Univ Alabama Birmingham, Dept Pathol, Ctr Free Radical Biol, Birmingham, AL 35294 USA. [Chatham, John C.] Univ Alabama Birmingham, Div Mol & Cellular Pathol, Dept Pathol, Birmingham, AL USA. [Kim, Yonghyun] Univ Alabama, Dept Chem & Biol Engn, Tuscaloosa, AL USA. [Goping, Ing Swie] Univ Alberta, Dept Biochem, Edmonton, AB, Canada. [Diaz-Laviada, Ines] Univ Alcala De Henares, Dept Syst Biol, Biochem & Mol Biol Unit, Sch Med, Madrid, Spain. [Medema, Jan Paul] Univ Amsterdam, Acad Med Ctr, Lab Expt Oncol & Radiobiol, Meibergdreef 9, NL-1105 AZ Amsterdam, North Holland, Netherlands. [Juenemann, Katrin] Univ Amsterdam, Acad Med Ctr, Dept Cellbiol & Histol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. [Meijer, Alfred J.] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. [Berkhout, Ben] Univ Amsterdam, Acad Med Ctr, Lab Expt Virol, Ctr Infect & Immun Amsterdam CINIMA, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. [Norga, Koenraad K.] Univ Antwerp, Dept Paediat Oncol, B-2020 Antwerp, Belgium. [De Meyer, Guido R. Y.; Martinet, Wim] Univ Antwerp, Lab Physiopharmacol, B-2020 Antwerp, Belgium. [Landowski, Terry H.] Univ Arizona, Ctr Canc, Dept Med, Tucson, AZ USA. [Kruer, Michael C.] Univ Arizona, Coll Med, Barrow Neurol Inst, Phoenix Childrens Hosp,Dept Child Hlth, Phoenix, AZ USA. [Riehle, Michael A.] Univ Arizona, Dept Entomol, Tucson, AZ USA. [Chen, Yin; Klimecki, Walter T.; Zhang, Donna D.] Univ Arizona, Dept Pharmacol & Toxicol, Coll Pharm, Tucson, AZ 85721 USA. [Ding, Zufeng; Mehta, Jawahar L.] Univ Arkansas Med Sci, Dept Cardiol, Little Rock, AR 72205 USA. [Voth, Daniel E.] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA. [MacMillan-Crow, Lee Ann; Parajuli, Nirmala] Univ Arkansas Med Sci, Dept Pharmacol Toxicol, Little Rock, AR 72205 USA. [Dridi, Sami] Univ Arkansas, Ctr Excellence Poultry Sci, Fayetteville, AR 72701 USA. [Konstantakou, Eumorphia G.; Stravopodis, Dimitrios J.; Trougakos, Ioannis P.; Velentzas, Athanassios D.] Univ Athens, Dept Cell Biol & Biophys, Fac Biol, Athens, Greece. [Mpakou, Vassiliki E.] Univ Athens, Sch Med, Dept Internal Med 2, Athens, Greece. [Mpakou, Vassiliki E.] Attikon Univ, Gen Hosp, Res Inst, Athens, Greece. [Kampinga, Harm H.] Univ Groningen, Univ Med Ctr Groningen, Dept Cell Biol, Groningen, Netherlands. [Pierre, Philippe] Univ Aveiro, Inst Res Biomed iBiMED, Aveiro Hlth Sci Program, Aveiro, Portugal. [Neves, Bruno M.] Univ Aveiro QOPNA, Dept Chem, Aveiro, Portugal. [Claria, Joan; Lopez-Vicario, Cristina] Univ Barcelona, Dept Biochem & Mol Genet, Hosp Clin, IDIBAPS CIBERehd, Barcelona, Spain. [Ambrosio, Santiago] Univ Barcelona, Sch Med, Campus Bellvitge, Lhospitalet De Llobregat, Spain. [Cocco, Tiziana] Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Organs Senses, Bari, Italy. [Tucci, Marco] Univ Bari Aldo Moro, Dept Biomed Sci & Clin Oncol, Bari, Italy. [Simone, Cristiano] Univ Bari Aldo Moro, Div Med Genet, DIMO, Sch Med, Bari, Italy. [Castets, Perrine; Ruegg, Markus A.; Spang, Anne] Univ Basel, Biozentrum, Basel, BS, Switzerland. [Boeckler, Stefan; Westermann, Benedikt] Univ Bayreuth, Cell Biol, Bayreuth, Germany. [Steegborn, Clemens] Univ Bayreuth, Dept Biochem, Bayreuth, Germany. [Harhaji-Trajkovic, Ljubica] Univ Belgrade, Inst Biol Res Sinisa Stankov, Belgrade, Serbia. [Kravic-Stevovic, Tamara] Univ Belgrade, Inst Histol & Embryol, Sch Med, Belgrade, Serbia. [Markovic, Ivanka] Univ Belgrade, Inst Med & Clin Biochem, Fac Med, Belgrade, Serbia. [Trajkovic, Vladimir] Univ Belgrade, Sch Med, Belgrade, Serbia. [Bumbasirevic, Vladimir] Univ Belgrade, Sch Med, Inst Histol & Embryol, Belgrade, Serbia. [Tschan, Mario P.] Univ Bern, Div Expt Pathol, Inst Pathol, Bern, Switzerland. [Arcaro, Alexandre] Univ Bern, Div Pediat Hematol Oncol, Dept Clin Res, Bern, Switzerland. [Buetikofer, Peter] Univ Bern, Inst Biochem & Mol Med, Bern, Switzerland. [Simon, Hans-Uwe] Univ Bern, Inst Pharmacol, Bern, Switzerland. [Sarkar, Sovan; Ward, Carl] Univ Birmingham, Inst Biomed Res, Inst Canc & Genom Sci, Coll Med & Dent Sci, Birmingham, W Midlands, England. [Taylor, Graham S.] Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, W Midlands, England. [Martelli, Alberto M.] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy. [Cetrullo, Silvia; Flamigni, Flavio] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie, Bologna, Italy. [Walter, Jochen] Univ Bonn, Dept Neurol, Bonn, Germany. [Haas, Albert; Hoehfeld, Joerg] Univ Bonn, Inst Cell Biol, Bonn, Germany. [Till, Andreas] Univ Bonn, Inst Reconstruct Neurobiol, Bonn, Germany. [Fanzani, Alessandro] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy. [Lane, Jon D.] Univ Bristol, Sch Biochem, Bristol, Avon, England. [Greenhough, Alexander] Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England. [Roberge, Michel; Yip, Calvin K.] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V5Z 1M9, Canada. [Johnson, James D.; Nabi, Ivan R.] Univ British Columbia, Dept Cellular & Physiol Sci, Vancouver, BC V5Z 1M9, Canada. [Wang, Yu Tian] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada. [Wang, Yu Tian] Brain Res Ctr, Vancouver, BC, Canada. [Luo, Honglin] Univ British Columbia, Dept Pathol & Lab Med, James Hogg Res Ctr, Vancouver, BC V5Z 1M9, Canada. [Shi, Junyan] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada. [Toker, Lilach] Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada. [Gleave, Martin] Univ British Columbia, Dept Urol Sci, Vancouver, BC V5Z 1M9, Canada. [Jiang, Xiaoyan] Univ British Columbia, Med Genet & BC Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1M9, Canada. [Piret, James M.] Univ British Columbia, Michael Smith Labs, Dept Chem & Biol Engn, Vancouver, BC V5Z 1M9, Canada. [Turner, Robin F. B.] Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, Canada. [Blanco, Guillermo A.] Univ Buenos Aires, IDEHU CONICET, Fac Pharm & Biochem, Buenos Aires, DF, Argentina. [Alvarez, Silvia] Univ Buenos Aires, Inst Biochem & Biophys, Sch Pharm & Biochem, Buenos Aires, DF, Argentina. [Vaccaro, Maria I.] Univ Buenos Aires, Natl Council Sci & Tech Res CONICET, Inst Biochem & Mol Med, Dept Pathophysiol,Sch Pharm & Biochem, Buenos Aires, DF, Argentina. [Perrotta, Ida] Univ Calabria, Dept Biol Ecol & Earth Sci, Lab Electron Microscopy, I-87036 Cosenza, Italy. [Aquila, Saveria] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, I-87036 Cosenza, Italy. [Russo, Rossella] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Sect Preclin & Translat Pharmacol, I-87036 Cosenza, Italy. [Chakrabarti, Gopal] Univ Calcutta, Dept Biotechnol, Dr BC Guha Ctr Genet Engn & Biotechnol, Kolkata, WB, India. [Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada. [Schatzl, Hermann M.] Univ Calgary, Fac Vet Med, Calgary, AB, Canada. [Hurley, James H.; Thorner, Jeremy] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA. [Ge, Liang; Schekman, Randy] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA. [Kung, Hsing-Jien] Univ Calif Davis, Ctr Canc, Davis, CA 95616 USA. [Luckhart, Shirley; Pakpour, Nazzy] Univ Calif Davis, Dept Med Microbiol & Immunol, Sch Med, Davis, CA 95616 USA. [Powers, Ted] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA. [Gomes, Aldrin V.] Univ Calif Davis, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA. [Dinesh-Kumar, Savithrama P.] Univ Calif Davis, Dept Plant Biol, Davis, CA 95616 USA. [Dinesh-Kumar, Savithrama P.] Coll Biol Sci, Genome Ctr, Davis, CA USA. [van Doorn, Wouter G.] Univ Calif Davis, Mann Lab, Dept Plant Sci, Davis, CA 95616 USA. [Edinger, Aimee L.] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA. [Chen, Jeff W.] Univ Calif Irvine, Dept Neurosurg, Irvine, CA USA. [Steffan, Joan] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA. [Ganesan, Anand K.] Univ Calif Irvine, Irvine, CA USA. [Xia, Tian] Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA. [Costes, Safia] Univ Calif Los Angeles, David Geffen Sch Med, Larry Hillblom Islet Res Ctr, Los Angeles, CA 90095 USA. [Le Roch, Karine G.] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA. [Steele, John W.] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA. [Lee, Jongdae; Satriano, Joseph] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Sigurdson, Christina J.] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA. [Spector, Stephen A.] Univ Calif San Diego, Dept Pediat Div Infect Dis, La Jolla, CA 92093 USA. [Campbell, Grant R.; Ordonez, Paulina] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. [Guan, Kun-Liang] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA. [Guan, Kun-Liang] Moores Canc Ctr, La Jolla, CA USA. [Miyamoto, Shigeki] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA. [La Spada, Albert R.] Univ Calif San Diego, Dept Cellular & Mol Med, Div Biol Sci, Inst Genom Med, La Jolla, CA 92093 USA. [La Spada, Albert R.] Univ Calif San Diego, Dept Neurosci, Div Biol Sci, Inst Genom Med, La Jolla, CA 92093 USA. [La Spada, Albert R.] Univ Calif San Diego, Dept Pediat, Div Biol Sci, Inst Genom Med, La Jolla, CA 92093 USA. [Kiger, Amy A.] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA. [Liu, Jing-Jing; Nazarko, Taras Y.] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA. [Till, Andreas] Univ Calif San Diego, San Diego Ctr Syst Biol, La Jolla, CA 92093 USA. [Cohen, Ezra E. W.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. [Soontornniyomkij, Virawudh] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA. [Gustafsson, Asa B.] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA. [Cox, Jeffery S.] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA. [Aghi, Manish K.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA. [An, Zhenyi] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Hetz, Claudio; Matus, Soledad] FONDAP Ctr Gerosci Brain Hlth & Metab, Santiago, Chile. [Gestwicki, Jason E.] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA. [Sarwal, Minnie M.] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. [Finkbeiner, Steven] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Finkbeiner, Steven] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA. [Finkbeiner, Steven] Gladstone Inst Neurol Dis, San Francisco, CA USA. [Debnath, Jayanta; Margeta, Marta] Univ Calif San Francisco, Sch Med, Dept Pathol, San Francisco, CA 94143 USA. [Kajimura, Shingo] Univ Calif San Francisco, UCSF Diabet Ctr, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA. [Montell, Craig] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA. [Kaser, Arthur] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England. [Rubinsztein, David C.] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 2QQ, England. [Floto, R. Andres] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England. [Narita, Masashi] Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Cambridge, England. [Miller-Fleming, Leonor] Univ Cambridge, Dept Biochem, Cambridge, England. [Renna, Maurizio] Univ Cambridge, Dept Med Genet, Cambridge Inst Med Res, Cambridge, England. [Randow, Felix] Univ Cambridge, Dept Med, Addenbrookes Hosp, Cambridge CB2 2QQ, England. [Beale, Rupert] Univ Cambridge, Dept Pathol, Div Virol, Tennis Court Rd, Cambridge CB2 1QP, England. [Amantini, Consuelo] Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy. [Nabissi, Massimo] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy. [Santoni, Giorgio] Univ Camerino, Sch Pharm, Sect Expt Med, I-62032 Camerino, MC, Italy. [Ferreira-Halder, Carmen Verissima] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Campinas, SP, Brazil. [Dobson, Renwick C. J.] Univ Canterbury, Biomol Interact Ctr, Sch Biol Sci, Christchurch 1, New Zealand. [Prince, Sharon] Univ Cape Town, Dept Human Biol, ZA-7925 Cape Town, Western Provinc, South Africa. [Davids, Lester M.] Univ Cape Town, Redox Lab, Dept Human Biol, ZA-7925 Cape Town, South Africa. [Zervos, Antonis S.] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA. [He, Yu-Ying] Univ Chicago, Dept Med, Dermatol Sect, Chicago, IL 60637 USA. [Choi, Jayoung; Hwang, Seungmin] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA. [Mastrianni, James A.] Univ Chicago, Pritzker Sch Med, Dept Neurol, Chicago, IL 60637 USA. [Macleod, Kay F.] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA. [Corbalan, Ramon; Garcia Nannig, Lorena] Univ Chile, Adv Ctr Chron Dis ACCDiS, Div Cardiovasc Dis, Fac Med, Santiago, Chile. [Pedrozo, Zully] P Catholic Univ Chile, Adv Ctr Chron Dis ACCDiS, Fac Med, Santiago, Chile. [Matus, Soledad] Univ Chile, Biomed Neurosci Inst, Santiago, Chile. [Segura-Aguilar, Juan] Univ Chile, Fac Med, ICBM Mol & Clin Pharmacol, Santiago 7, Chile. [Hetz, Claudio] Univ Chile, Fac Med, Inst Biomed Sci, Ctr Mol Studies Cell,Program Cellular,Mol Biol &, Santiago 7, Chile. [Weaver, Timothy E.] Univ Cincinnati, Coll Med, Cincinnati Childrens Res Fdn, Cincinnati, OH USA. [Weaver, Timothy E.] Dept Pediat, Cincinnati, OH USA. [Czyzyk-Krzeska, Maria F.; Guan, Jun-Lin; Wang, Chenran] Dept Pediat, Coll Med, Dept Canc Biol, Cincinnati, OH USA. [Robbins, Jeffrey] Univ Cincinnati, Cincinnati Childrens Hosp, Cincinnati, OH USA. [Choubey, Divaker] Univ Cincinnati, Cincinnati, OH USA. [Moreira, Paula I.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal. [Moreira, Paula I.] Fac Med, Coimbra, Portugal. [Cruz, Maria Teresa; Liberal, Joana] Univ Coimbra, Ctr Neurosci & Cell Biol, Coimbra, Portugal. [Cruz, Maria Teresa; Liberal, Joana] Fac Pharm, Coimbra, Portugal. [Vega-Naredo, Ignacio] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Cantanhede, Portugal. [Batista, Maria Teresa] Univ Coimbra, Coimbra, Portugal. [Cardoso, Sandra Morais] Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Coimbra, Portugal. [Pereira, Paulo C.] Univ Coimbra, IBILI, Fac Med, Coimbra, Portugal. [Fabri, Mario] Univ Cologne, Dept Dermatol, D-50931 Cologne, Germany. [Hoppe, Thorsten] Univ Cologne, Inst Genet, CECAD Res Ctr, D-50931 Cologne, Germany. [Noegel, Angelika A.] Univ Cologne, Inst Biochem 1, Fac Med, Cologne, Germany. [Eichinger, Ludwig] Univ Cologne, Fac Med, Ctr Biochem, D-50931 Cologne, Germany. [Edelstein, Charles L.] Univ Colorado, Boulder, CO 80309 USA. [Weekes, Colin D.] Univ Colorado, Div Med Oncol, Dept Med, Aurora, CO USA. [Agarwal, Rajesh; Raina, Komal] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO USA. [Jani, Alkesh] Univ Colorado, Denver, CO USA. [Jani, Alkesh] Denver VAMC, Denver, CO USA. [Levy, Jean M. Mulcahy] Univ Colorado, Dept Pediat, Ctr Canc & Blood Disorders, Aurora, CO USA. [Parker, Roy] Univ Colorado, HHMI, Dept Chem & Biochem, Aurora, CO USA. [Pugazhenthi, Subbiah] Univ Colorado, Sch Med, Anschutz Med Campus, Aurora, CO USA. [Reusch, Jane E. B.] Univ Colorado, Sch Med, Aurora, CO USA. [Pyeon, Dohun] Univ Colorado, Sch Med, Dept Immunol & Microbiol, Aurora, CO USA. [Bayer, K. Ulrich; Morgan, Michael J.; Thorburn, Andrew] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA. [Beckham, J. David] Univ Colorado, Sch Med, Div Infect Dis, Aurora, CO USA. [Frankel, Lisa B.; Issazadeh-Navikas, Shohreh; Lund, Anders H.] Univ Copenhagen, BRIC, Copenhagen, Denmark. [Petersen, Morten] Univ Copenhagen, Dept Biol, Copenhagen, Denmark. [Olsson, Stefan] Univ Copenhagen, Dept Plant & Environm Sci, Sect Genet & Microbiol, Copenhagen, Denmark. [Tavernarakis, Nektarios] Univ Crete, Dept Basic Sci, Fac Med, Iraklion, Greece. [Tavernarakis, Nektarios] Univ Crete, Inst Mol Biol & Biotechnol, Iraklion, Greece. [Chamilos, Georgios; Kyrmizi, Irene] Univ Crete, Sch Med, Dept Infect Dis, Iraklion, Greece. [Promponas, Vasilis J.] Univ Cyprus, Dept Biol Sci, Bioinformat Res Lab, CY-1678 Nicosia, Cyprus. [Fesus, Laszlo] Univ Debrecen, Debrecen, Hungary. [Lekli, Istvan] Univ Debrecen, Fac Pharm, Dept Pharmacol, Debrecen, Hungary. [van Golen, Kenneth L.] Univ Delaware, Dept Biol Sci, Newark, DE USA. [van Golen, Kenneth L.] Univ Delaware, Ctr Translat Canc Res, Newark, DE USA. [Rocha, Sonia] Univ Dundee, Ctr Gene Regulat & Express, Coll Life Sci, Dundee DD1 4HN, Scotland. [Ganley, Ian G.] Univ Dundee, MRC Prot Phosphorylat & Ubiquitylat Unit, Sch Life Sci, Dundee, Scotland. [Wileman, Tom] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England. [Pesonen, Maija] Univ Eastern Finland, Fac Hlth Sci, Sch Pharm Toxicol, Kuopio, Finland. [Kaarniranta, Kai] Univ Eastern Finland, Kuopio Univ Hosp, Dept Ophthalmol, Kuopio, Finland. [Digard, Paul] Univ Edinburgh, Easter Bush, Roslin Insitute, Edinburgh EH8 9YL, Midlothian, Scotland. [Gammoh, Noor] Univ Edinburgh, Edinburgh Canc Res Ctr, Edinburgh, Midlothian, Scotland. [Wilkinson, Simon] Univ Edinburgh, Edinburgh Canc Res UK Ctr, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland. [Distler, Joerg H. W.] Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany. [Moore, Michael N.] Univ Exeter, Sch Med, ECEHH, Truro, Cornwall, England. [Talbot, Nicholas J.] Univ Exeter, Sch Biosci, Exeter, Devon, England. [Pena, Fernando J.; Tapia, Jose A.] Univ Extremadura, Dept Med, Fac Vet Med, Caceres, Spain. [Neri, Luca M.; Pinton, Paolo] Univ Ferrara, Dept Morphol Surg & Expt Med, I-44100 Ferrara, Italy. [Papini, Alessio] Univ Florence, Dept Biol, Florence, Italy. [Dunn, William A., Jr.] Univ Florida, Coll Med, Dept Anat & Cell Biol, Gainesville, FL USA. [Notterpek, Lucia] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL USA. [Joseph, Anna-Maria] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA. [Wohlgemuth, Stephanie E.] Univ Florida, Dept Anim Sci, IFAS Coll Agr & Life Sci, Gainesville, FL 32611 USA. [Adhihetty, Peter J.; Powers, Scott K.] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL USA. [Maegawa, Gustavo] Univ Florida, Dept Pediat Genet & Metab, Gainesville, FL USA. [Behrns, Kevin E.] Univ Florida, Dept Surg, Gainesville, FL USA. [Kim, Jae-Sung] Univ Florida, Gainesville, FL USA. [Leeuwenburgh, Christiaan] Univ Florida, Inst Aging, Gainesville, FL USA. [Dengjel, Joern] Univ Freiburg, Dept Dermatol, Med Ctr, Ctr Biol Syst Anal ZBSA, Hugstetter Str 55, D-79106 Freiburg, Germany. [Yang, Zhihong] Univ Fribourg, Dept Med, Div Physiol, Fac Sci, CH-1700 Fribourg, Switzerland. [Ming, Xiu-Fen; Xiong, Yuyan] Univ Fribourg, Dept Med, Div Physiol, CH-1700 Fribourg, Switzerland. [Gannage, Monique] Univ Geneva, Sch Med, Dept Pathol & Immunol, CH-1211 Geneva, Switzerland. [Gogal, Robert M., Jr.] Univ Georgia, Coll Vet Med, Dept Biosci & Diagnost Imaging, Athens, GA 30602 USA. [Quinn, Frederick] Univ Georgia, Dept Infectious Dis, Athens, GA 30602 USA. [Leung, Hing Y.; Ryan, Kevin M.; Tait, Stephen W. G.] Univ Glasgow, Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland. [Leung, Hing Y.; McNeish, Iain A.] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland. [Evans, Thomas J.] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland. [Helgason, Gudmundur Vignir] Univ Glasgow, Wolfson Wohl Canc Res Ctr, MVLS, Inst Canc Sci, Glasgow, Lanark, Scotland. [Jackson, Daniel John] Univ Gottingen, Dept Geobiol, D-37073 Gottingen, Germany. [Lingor, Paul] Univ Gottingen, Dept Neurol, D-37073 Gottingen, Germany. [Carmona-Gutierrez, Didac; Eisenberg, Tobias; Kohlwein, Sepp D.; Madeo, Frank] Graz Univ, Inst Mol Biosci, BioTechMed Graz, Graz, Austria. [van der Klei, Ida J.; Williams, Chris] Univ Groningen, Mol Cell Biol, Groningen, Netherlands. [Lemberg, Marius K.] Heidelberg Univ, Ctr Mol Biol, Heidelberg, Germany. [Parlato, Rosanna] Heidelberg Univ, Inst Anat & Cell Biol, Heidelberg, Germany. [Lindholm, Dan] Univ Helsinki, Biomedicum, Helsinki, Finland. [Eskelinen, Eeva-Liisa; Stratoulias, Vassilis] Univ Helsinki, Dept Biosci, Helsinki, Finland. [Hulmi, Juha J.] Univ Helsinki, Dept Physiol, Fac Med, Helsinki, Finland. [Wang, Yu] Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China. [Su, Yu-Xiong] Univ Hong Kong, Div Oral & Maxillofacial Surg, Fac Dent, Hong Hom, Hong Kong, Peoples R China. [Feng, Yibin] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. [Chang, Raymond Chuen-Chung] Univ Hong Kong, Lab Neurodegenerat Dis, Sch Biomed Sci, LKS Fac Med, Hong Kong, Hong Kong, Peoples R China. [Eriksen, Jason L.; Zhang, Yang] Univ Houston, Coll Pharm Pharmacol & Pharmaceut Sci, Houston, TX USA. [Frigo, Daniel E.] Univ Houston, Dept Biol & Biochem, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA. [Caplan, Allan B.] Univ Idaho, Plant Soil & Entomol Sci, Moscow, ID USA. [Yue, Beatrice Y. J. T.] Univ Illinois, Coll Med, Dept Ophthalmol & Visual Sci, Chicago, IL USA. [Zhou, Guofei] Univ Illinois, Coll Med, Dept Pediat, Chicago, IL USA. [Hu, Guochang] Univ Illinois, Dept Anesthesiol, Chicago, IL USA. [Hu, Guochang] Univ Illinois, Dept Pharmacol, Chicago, IL USA. [Shukla, Deepak] Univ Illinois, Dept Ophthalmol, Chicago, IL 60680 USA. [Shukla, Deepak] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60680 USA. [Nazarko, Volodymyr Y.; Segev, Nava] Univ Illinois, Deprtment Biochem & Mol Genet, Chicago, IL USA. [Sun, Jun] Univ Illinois, Div Gastroenterol & Hepatol, Dept Med, Chicago, IL USA. [Kemper, Jongsook Kim] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL USA. [Zhang, Guo-Chang] Univ Illinois, Inst Genom Biol, Urbana, IL USA. [Meryk, Andreas] Univ Innsbruck, Inst Biomed Aging Res, A-6020 Innsbruck, Austria. [Romanelli, Davide; Tettamanti, Gianluca] Univ Insubria, Dept Biotechnol & Life Sci, Varese, Italy. [Grose, Charles] Univ Iowa, Childrens Hosp, Iowa City, IA USA. [Lira, Vitor A.] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA USA. [Adams, Christopher M.] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA. [Monick, Martha M.] Univ Iowa, Dept Med, Iowa City, IA 52242 USA. [Fingert, John H.] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA. [Hulmi, Juha J.] Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland. [Marquez, Rebecca; Xu, Liang] Univ Kansas, Lawrence, KS 66045 USA. [Marquez, Rebecca; Xu, Liang] Univ Kansas, Ctr Canc, Dept Mol Biosci, Lawrence, KS 66045 USA. [Marquez, Rebecca; Xu, Liang] Univ Kansas, Ctr Canc, Dept Radiat Oncol, Lawrence, KS 66045 USA. [Chen, Qi; Ding, Wen-Xing] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66103 USA. [Hsu, Chin] Univ Kaohsiung, Med Univ, Dept Physiol, Fac Med,Coll Med, Kaohsiung, Taiwan. [Chen, Gang; Luo, Jia] Univ Kentucky, Coll Med, Dept Pharmacol & Nutrit Sci, Lexington, KY USA. [Rucker, Edmund B., III] Univ Kentucky, Dept Biol, Lexington, KY USA. [Dickson, Robert C.] Univ Kentucky, Dept Mol & Cellular Biochem, Lexington, KY USA. [Craven, Rolf J.] Univ Kentucky, Dept Pharmacol & Nutrit Sci, Lexington, KY USA. [St Clair, Daret] Univ Kentucky, Dept Toxicol & Canc Biol, Lexington, KY USA. [Frey, Norbert; Kuhn, Christian] Univ Kiel, Dept Cardiol, Kiel, Germany. [Rosenstiel, Philip] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany. [Huebbe, Patricia; Pallauf, Kathrin; Rimbach, Gerald] Univ Kiel, Inst Human Nutr & Food Sci, Kiel, Germany. [Denizot, Melanie] Univ La Reunion, CYROI, IRG Immunopathol & Infect Res Grouping, Reunion, Reunion. [Gravina, Giovanni Luca] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Div Radiotherapy & Radiobiol, I-67100 Laquila, Italy. [Mayer, Andreas] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland. [Clarke, Peter G. H.; Ginet, Vanessa; Puyal, Julien] Univ Lausanne, Dept Fundamental Neurosci, Fac Biol & Med, Lausanne, Switzerland. [Cottet, Sandra; Schorderet, Daniel F.] Univ Lausanne, Dept Ophthalmol, Lausanne, Switzerland. [Noureini, Sakineh Kazemi] Hakim Sabzevari Univ, Dept Biol, Fac Basic Sci, Sabzevar, Iran. [Andreadi, Catherine K.; Brown, Karen] Univ Leicester, Dept Canc Studies, Leicester, Leics, England. [Giorgini, Flaviano] Univ Leicester, Dept Genet, Leicester, Leics, England. [Garg, Abhishek D.] Univ Leuven, Campus Gasthuisberg, Dept Cellular & Mol Med, Lab Cell Death Res & Therapy, Leuven, Belgium. [Vandenberghe, Wim] Univ Leuven, Dept Neurosci, Leuven, Belgium. [Claerhout, Sofie] KU Leuven Univ Leuven, Ctr Human Genet, Leuven, Belgium. [Claerhout, Sofie] VIB Ctr Biol Dis, Leuven, Belgium. [Mottet, Denis] Univ Liege, GIGA Signal Transduct Dept, Prot Signalisat & Interact Lab, Liege, Belgium. [Staels, Bart] Univ Lille, INSERM UMR1011, Inst Pasteur Lille, Lille, France. [Terro, Faraj] Univ Limoges, Dept Histol & Cell Biol, Limoges, France. [Clague, Michael J.] Univ Liverpool, Cellular & Mol Physiol, Inst Translat Med, Liverpool L69 3BX, Merseyside, England. [Erman, Andreja] Univ Ljubljana, Inst Cell Biol, Fac Med, Ljubljana, Slovenia. [Campanella, Michelangelo] Univ London, RVC Dept Comparat Biomed Sci, UCL Consortium Mitochondrial Res, London, England. [Sylvester, Paul W.] Univ Louisiana Monroe, Sch Pharm, Monroe, LA USA. [Cheng, Alan] Univ Louisville, Dept Biochem & Mol Genet, Louisville, KY 40292 USA. [Chesney, Jason; Telang, Sucheta] Univ Louisville, Dept Med Hem Onc, Louisville, KY 40292 USA. [Hill, Bradford G.] Univ Louisville, Dept Med, Inst Mol Cardiol, Diabet & Obes Ctr, Louisville, KY 40292 USA. [Sen, Utpal] Univ Louisville, Dept Physiol, Louisville, KY 40292 USA. [Li, Chi] Univ Louisville, James Graham Brown Canc Ctr, Dept Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA. [Kumar, Ashok] Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA. [Tyagi, Suresh C.] Univ Louisville, Sch Med, Dept Physiol & Biophys, Louisville, KY 40292 USA. [Kruger, Rejko] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Luxembourg, Luxembourg. [Lu, Jiahong] Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macau, Peoples R China. [Balzan, Rena] Univ Malta, Dept Physiol & Biochem, Fac Med & Surg, Msida, Malta. [Lisanti, Michael P.] Univ Manchester, Breakthrough Breast Canc Res Unit, Manchester Ctr Cellular Metab, Manchester M13 9PL, Lancs, England. [Tournier, Cathy] Univ Manchester, Fac Life Sci, Manchester, Lancs, England. [Sotgia, Federica] Univ Manchester, Inst Canc Sci, Fac Med & Human Sci, Manchester, Lancs, England. [Gibson, Spencer B.] Univ Manitoba, CancerCare Manitoba, Manitoba Inst Cell Biol, Dept Biochem, Winnipeg, MB, Canada. [Gibson, Spencer B.] Univ Manitoba, Dept Med Genet & Immunol, Winnipeg, MB, Canada. [Ghavami, Saeid] Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada. [Halayko, Andrew J.] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada. [Kirshenbaum, Lorrie A.] Univ Manitoba, Inst Cardiovasc Sci, Coll Med, Fac Hlth Sci, Winnipeg, MB, Canada. [Sharma, Shweta] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA. [Zhang, Yanjin] Univ Maryland, Dept Vet Med, College Pk, MD 20742 USA. [Fang, Shengyun] Univ Maryland, Sch Med, Sch Med, Ctr Biomed Engn & Technol,Dept Physiol, Baltimore, MD 21201 USA. [Wu, Junfang] Univ Maryland, Sch Med, Dept Anesthesiol & Ctr Shock, Trauma & Anesthesiol Res STAR,Natl Study Ctr Trau, Baltimore, MD 21201 USA. [Lipinski, Marta M.] Univ Maryland, Sch Med, Dept Anesthesiol, Baltimore, MD 21201 USA. [Njar, Vincent C. O.] Univ Maryland, Sch Med, Dept Chem, Baltimore, MD 21201 USA. [Jackson, William T.; Kalvakolanu, Dhan V.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Yang, Peixin] Univ Maryland, Sch Med, Dept Obstet Gynecol & Reprod Sci, Baltimore, MD 21201 USA. [Aurelian, Laure] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA. [Cheng, Hua] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Baehrecke, Eric H.; Velentzas, Panagiotis D.] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA. [Gao, Fen-Biao] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01605 USA. [Davis, Roger J.] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA. [Maiese, Kenneth] Univ Med & Dent New Jersey, Cellular & Mol Signaling, Newark, NJ 07103 USA. [Lindqvist, Lisa M.] Cell Signalling & Cell Death Div, Parkville, Vic, Australia. [Lindqvist, Lisa M.] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Dept Med Biol, Parkville, Vic 3052, Australia. [White, Anthony R.] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia. [Delbridge, Lea M. D.] Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia. [Pepe, Salvatore] Univ Melbourne, Murdoch Childrens Res Inst, Dept Paediat, Royal Childrens Hosp, Melbourne, Vic, Australia. [Kim, Michael D.] Univ Miami, Miller Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA. [Man, Na] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA. [Soleimanpour, Scott A.] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA. [Lieberman, Andrew P.; Lukacs, Nicholas W.] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA. [Towns, Roberto] Univ Michigan, Ann Arbor, MI 48109 USA. [Duncan, Mara C.] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA. [Swanson, Michele S.] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA. [Lee, Jun Hee] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA. [Klionsky, Daniel J.; Feng, Yuchen; Gatica, Damian; Jin, Meiyan; Kumar, Anuj; Liu, Xu; Orban, Daniel P.; Parzych, Katherine R.; Wen, Xin; Xu, Haoxing; Xu, Ziheng; Yao, Zhiyuan] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA. [Zacks, David N.] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA. [Xie, Chuan-Ming] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA. [Sun, Yi; Zhao, Yongchao] Univ Michigan, Dept Radiat Oncol, Div Radiat & Canc Biol, Ann Arbor, MI 48109 USA. [Klionsky, Daniel J.; Ariosa, Aileen R.; Bernard, Amelie; Delorme-Axford, Elizabeth; Feng, Yuchen; Gatica, Damian; Jin, Meiyan; Liu, Xu; Orban, Daniel P.; Parzych, Katherine R.; Popelka, Hana; Wen, Xin; Xu, Ziheng; Yao, Zhiyuan] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA. [Burmeister, Margit] Univ Michigan, Mol & Behav Neurosci Inst, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. [Burmeister, Margit] Univ Michigan, Mol & Behav Neurosci Inst, Dept Psychiat, Ann Arbor, MI 48109 USA. [Burmeister, Margit] Univ Michigan, Mol & Behav Neurosci Inst, Dept Human Genet, Ann Arbor, MI 48109 USA. [Hua, Ya] Univ Michigan, Neurosurg, Ann Arbor, MI 48109 USA. [Kahana, Alon] Univ Michigan, Ophthalmol & Visual Sci, Kellogg Eye Ctr, Ann Arbor, MI 48109 USA. [Liu, Fei] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA. [Minucci, Saverio] Univ Milan, Dept Expt Oncol, European Inst Oncol, Milan, Italy. [Minucci, Saverio] Dept Biosci, Milan, Italy. [Avagliano, Laura; Marconi, Anna Maria] Univ Milan, Dept Hlth Sci, Milan, Italy. [Vitale, Giovanni] Univ Milan, Ist Auxol Italiano, Dept Clin Sci & Community Hlth, Milan, Italy. [Ludovico, Paula] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, Braga, Portugal. [Sousa, Maria Joao] Univ Minho, Mol & Environm Biol Ctr CBMA, Dept Biol, Braga, Portugal. [Ludovico, Paula] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal. [Kim, Do-Hyung] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA. [Mauvezin, Caroline] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA. [Abedin, Md Joynal] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. [Karim, Md Razaul] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA. [Saluja, Ashok K.] Univ Minnesota, Dept Surg, Box 242 UMHC, Minneapolis, MN 55455 USA. [Imbriano, Carol; Pinti, Marcello] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy. [Gibellini, Lara] Univ Modena & Reggio Emilia, Dept Surg Med Dent & Morphol Sci, Modena, Italy. [Cossarizza, Andrea] Univ Modena & Reggio Emilia, Sch Med, Dept Surg Med Dent & Morphol Sci, Modena, Italy. [Koechlin-Ramonatxo, Christelle] Univ Montpellier, INRA, UMR 866, Dynam Musculaire & Metab, F-34059 Montpellier, France. [Candau, Robin] Univ Montpellier, UMR 866, Dynam Musculaire & Metab, F-34059 Montpellier, France. [Godefroy, Nelly; Martinand-Mari, Camille] Univ Montpellier, UMR 5554, F-34059 Montpellier, France. [Valdor, Rut] Univ Murcia, IMIB Virgen Arrixaca Hosp, Human Anat & Psycobiol Dept, Cell Therapy & Hematopoiet Transplantat Unit, Murcia, Spain. [Shidoji, Yoshihiro] Nagasaki Univ, Mol & Cellular Biol, Grad Sch Human Hlth Sci, Nagasaki 852, Japan. [Arnould, Thierry; Michiels, Carine] Univ Namur, Lab Biochem & Cell Biol URBC, Namur Res Inst Life Sci NARILIS, Namur, Belgium. [Hamer, Isabelle] Univ Namur, Res Unit Mol Physiol URPhyM, Namur, Belgium. [Ciarcia, Roberto; De Martino, Luisa; Fiorito, Filomena; Florio, Salvatore; Montagnaro, Serena; Pagnini, Ugo] Univ Naples Federico II, Dept Vet Med & Anim Prod, Naples, Italy. [Donohue, Terrence M., Jr.; Thomes, Paul G.] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE USA. [Buch, Shilpa] Univ Nebraska Med Ctr, Omaha, NE USA. [Franco, Rodrigo] Univ Nebraska, Redox Biol Ctr, Lincoln, NE USA. [Franco, Rodrigo] Sch Vet Med & Biomed Sci, Lincoln, NE USA. [Ozbun, Michelle A.] Univ New Mexico, Ctr Comprehens Canc, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA. [Dokladny, Karol; Moseley, Pope L.] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA. [Cleyrat, Cedric] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA. [Cleyrat, Cedric] Canc Res & Treatment Ctr, Albuquerque, NM USA. [Deretic, Vojo; Kimura, Tomonori; Mandell, Michael A.] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA. [Cheluvappa, Rajkumar] Univ New S Wales, Inflammat & Infect Res Ctr, Sch Med Sci, Sydney, NSW, Australia. [Kaakoush, Nadeem O.] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia. [Zhang, Xu Dong] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW 2300, Australia. [Jin, Lei] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW 2308, Australia. [Auberger, Patrick] Univ Nice, INSERM U1065, C3M, Nice, France. [Hofman, Paul] Univ Nice Sophia Antipolis, INSERM U1081, CNRS 7284, Fac Med, F-06189 Nice, France. [Bulavin, Dmitry V.] Univ Nice Sophia Antipolis, IRCAN, F-06189 Nice, France. [Vouret-Craviari, Valerie] Univ Nice Sophia Antipolis, IRCAN, F-06189 Nice, France. [Aoki, Hiroshi] Niigata Univ, Dept Neurosurg, Brain Res Inst, Niigata, Japan. [Bultman, Scott J.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA. [Ting, Jenny Pan-yun] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA. [Der, Channing J.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Ting, Jenny Pan-yun] Univ N Carolina, Lineberger Comprehens Canc Ctr, Inst Inflammatory Dis, Ctr Translat Immunol, Chapel Hill, NC 27599 USA. [Kawula, Thomas] Univ N Carolina, Microbiol & Immunol, Chapel Hill, NC USA. [Wu, Min] Univ N Dakota, Dept Biomed Sci, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA. [Basu, Alakananda] Univ N Texas, Hlth Sci Ctr, Dept Mol & Med Genet, Ft Worth, TX USA. [Layfield, Robert] Univ Nottingham, Sch Life Sci, Nottingham NG7 2RD, England. [Adachi, Hiroaki] Univ Occupat & Environm Hlth, Sch Med, Dept Neurol, Fukuoka, Japan. [Harada, Masaru] Univ Occupat & Environm Hlth, Dept Internal Med 3, Kitakyushu, Fukuoka, Japan. [Xu, Jian] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA. [Ramesh, Rajagopal; Zhao, Zhizhuang J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA. [Xie, Zhonglin] Univ Oklahoma, Hlth Sci Ctr, Sect Mol Med, Dept Med, Oklahoma City, OK USA. [Jain, Ashish; Rusten, Tor Erik] Univ Oslo, Ctr Canc Biomed, Oslo, Norway. [Seglen, Per O.] Univ Oslo, Ctr Mol Med Norway NCMM, Oslo, Norway. [Torgersen, Maria Lyngaas] Univ Oslo, Dept Biochem, Inst Canc Res, Oslo, Norway. [Mills, Ian G.] Univ Oslo, Dept Mol Oncol, Dept Urol, Oslo, Norway. [Nilsen, Hilde] Univ Oslo, Dept Clin Mol Biol, Oslo, Norway. [Petrovski, Goran] Univ Oslo, Dept Ophthalmol, Oslo, Norway. [Mills, Ian G.] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Lisburn Rd, Belfast, Antrim, North Ireland. [Blomhoff, Heidi Kiil; Simonsen, Anne] Univ Oslo, Inst Basic Med Sci, Oslo, Norway. [Engedal, Nikolai; Gerner, Lisa] Univ Oslo, Oslo Univ Hosp, Ctr Mol Med Norway, Nord EMBL Partnership, Oslo, Norway. [Hensel, Michael] Univ Osnabrueck, Div Microbiol, Osnabruck, Germany. [Ungermann, Christian] Univ Osnabrueck, Fachbereich Biol Chem, Osnabruck, Germany. [Slack, Ruth] Univ Ottawa, Dept Cellular & Mol Med, Fac Med, Ottawa, ON, Canada. [Gibbings, Derrick J.] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada. [Marino, Guillermo] Univ Oviedo, Dept Anim Physiol, Fac Med, Campus Cristo, Oviedo, Spain. [Buchan, Alastair M.] Univ Oxford, Acute Stroke Programme, Radcliffe Dept Med, Oxford, England. [Hammond, Ester M.] Univ Oxford, CRUK MRC Oxford Inst Radiat Oncol, Oxford, England. [Poulton, Joanna] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England. [Brini, Marisa; Valle, Luisa Dalla; Scovassi, A. Ivana] Univ Padua, Dept Biol, Padua, Italy. [Bonaldo, Paolo; Chen, Peiwen; Grumati, Paolo] Univ Padua, Dept Mol Med, Padua, Italy. [Viola, Giampietro] Univ Padua, Dept Womans & Childs Hlth, Lab Oncohematol, Padua, Italy. [Monick, Martha M.; Sandri, Marco; Zaglia, Tania] Univ Padua, Venetian Inst Mol Med, Dept Biomed Sci, Padua, Italy. [Agnello, Maria; Chiarelli, Roberto; Luparello, Claudio; Roccheri, Maria Carmela] Univ Palermo, Dipartimento Sci &Tecnol Biol, Chim & Farmaceutiche STEBICEF, Palermo, Italy. [Bettuzzi, Saverio; Rizzi, Federica] Univ Parma, Dept Biomed Biotechnol & Translat Sci, I-43100 Parma, Italy. [Comincini, Sergio; Palumbo, Silvia] Univ Pavia, Dept Biol & Biotechnol, Via Palestro 3, I-27100 Pavia, Italy. [Emanuele, Enzo] Univ Pavia, Dept Hlth Sci, Via Palestro 3, I-27100 Pavia, Italy. [Koumenis, Constantinos] Univ Penn, Perelman Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA. [O'Dwyer, Peter J.; Vogl, Dan T.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Gonzalez-Alegre, Pedro] Univ Penn, Ctr Cell & Mol Therapy, Children Hosp Philadelphia, Dept Neurol,Perelman Sch Med, Philadelphia, PA 19104 USA. [Mitchell, Claire H.] Univ Penn, Dept Anat & Cell Biol, Philadelphia, PA 19104 USA. [Boesze-Battaglia, Kathleen] Univ Penn, Dept Biochem, SDM, Philadelphia, PA 19104 USA. [Cherry, Sara] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. [Zhang, Lin] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA. [Zhang, Lin] Perelman Sch Med, Philadelphia, PA USA. [Sanchez, Anthony M. J.] Univ Perpignan Via Domitia, Lab Europee Performance St Altitude, EA 4604, Ft Romeu, France. [Romani, Luigina] Univ Perugia, Dept Expt Med, I-06100 Perugia, Italy. [De Tata, Vincenzo; Fornai, Francesco; Lenzi, Paola] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy. [Cavallini, Gabriella] Univ Pisa, Interdepartmental Res Ctr Biol & Pathol Aging, Pisa, Italy. [Singh, Shivendra V.] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr Res Pavil, Pittsburgh, PA USA. [Johnson, Daniel E.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Tsung, Allan] Univ Pittsburgh, Med Ctr, Dept Surg, Pittsburgh, PA USA. [Gomez, Hernando] Univ Pittsburgh, Dept Crit Care Med, Ctr Crit Care Nephrol, Clin Res Invest & Syst Modeling Acute Illness, Pittsburgh, PA USA. [Coyne, Carolyn B.] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA USA. [Rabinowich, Hannah] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA. [Kang, Rui; Tang, Daolin] Univ Pittsburgh, Dept Surg, Hillman Canc Ctr, Pittsburgh, PA USA. [Fan, Jie; Lee, Yong J.] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA. [Lotze, Michael T.] Univ Pittsburgh, Dept Surg, Inst Canc, Pittsburgh, PA USA. [Perlmutter, David H.] Univ Pittsburgh, Pittsburgh, PA USA. [Ouyang, Hongjiao] Univ Pittsburgh, Sch Dent Med, Dept Endodont, Pittsburgh, PA USA. [Kaynar, A. Murat] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA USA. [Kaynar, A. Murat] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA. [Lu, Binfeng] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA. [Chu, Charleen T.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA. [Chu, Charleen T.] Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15260 USA. [Pak, Stephen C.; Silverman, Gary A.] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15260 USA. [Zhang, Lin] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA. [Stang, Michael T.] Univ Pittsburgh, Sch Med, Dept Surg, Div Endocrine Surg, Pittsburgh, PA 15260 USA. [Isenberg, Jeffrey S.] Univ Pittsburgh, Vasc Med Inst, Pittsburgh, PA 15260 USA. [Page, Guylene] Univ Poitiers, Mol Targets & Therapeut Alzheimers Dis EA3808, Poitiers, France. [Lima, Raquel T.; Seca, Hugo; Vasconcelos, M. Helena; Xavier, Cristina P. R.] Univ Porto, Canc Drug Resistance Grp, IPA TIMUP, Inst Mol Pathol & Immunol, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Seca, Hugo; Vasconcelos, M. Helena] Univ Porto, Dept Biol Sci, Fac Pharm, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Lima, Raquel T.] Univ Porto, Dept Pathol & Oncol, Fac Pharm, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Lima, Raquel T.; Seca, Hugo; Vasconcelos, M. Helena; Xavier, Cristina P. R.] Univ Porto, i3S, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Joubert, Annie M.; Nolte, Elsie Magdalena; Theron, Anne E.] Univ Pretoria, Dept Physiol, ZA-0002 Pretoria, Gauteng, South Africa. [Asselin, Eric] Univ Quebec Trois Rivieres, Dept Biol & Med, Trois Rivieres, PQ GA9 5H7, Canada. [Walker, Mark J.] Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld, Australia. [Walker, Mark J.] Sch Chem & Mol Biosci, Brisbane, Qld, Australia. [Wolvetang, Ernst J.] Univ Queensland, AIBN, Brisbane, Qld, Australia. [Manzoni, Claudia] Univ Reading, Sch Pharm, Reading, Berks, England. [Lewis, Patrick A.] Univ Reading, Sch Pharm, Whiteknights, Reading, Berks, England. [Brookes, Paul S.; Johnson, Gail V. W.] Univ Rochester, Med Ctr, Dept Anesthesiol, Rochester, NY 14642 USA. [Sparks, Janet D.] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA. [Giordano, Antonio] Univ Siena, Dept Med Surg & Neurosci, Via Laterina 8, I-53100 Siena, Italy. [Sciarretta, Sebastiano] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Latina, Italy. [Aquilano, Katia; Campello, Silvia; Ciriolo, Maria Rosa; Di Bartolomeo, Sabrina; Filomeni, Giuseppe; Barbato, Daniele Lettieri; Piacentini, Mauro] Univ Roma Tor Vergata, Dept Biol, Rome, Italy. [Schiavi, Alfonso] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy. [Franco, Rodrigo] Univ Roma Tor Vergata, Dept Chem, Rome, Italy. [Ozbun, Michelle A.] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Rome, Italy. [Bernassola, Francesca] Univ Roma Tor Vergata, Dept Expt Med & Surg, Rome, Italy. [Melino, Gerry] Univ Roma Tor Vergata, Dept Surg & Expt Med, Rome, Italy. [Di Daniele, Nicola; Federici, Massimo; Menghini, Rossella] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy. [Cecconi, Francesco; Corazzari, Marco] Univ Roma Tor Vergata, Dept Biol, Rome, Italy. [Sibirny, Andriy A.] Univ Rzeszow, Inst Biol, Rzeszow, Poland. [Dini, Luciana] Univ Salento, Dept Biol & Environm Sci & Technol, Lecce, Italy. [Fimia, Gian Maria] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Lecce, Italy. [Iovane, Valentina] Univ Salento, Dept Pharm, Salerno, Italy. [Valente, Enza Maria] Univ Salento, Sect Neurosci, Dept Med & Surg, Salerno, Italy. [Machado-Santelli, Glaucia M.] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP, Brazil. [Goncalves, Dawit A. P.; Kettelhut, Isis do Carmo; Machado, Juliano] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP, Brazil. [Navegantes, Luiz C.; Silveira, Wilian A.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP, Brazil. [Brum, Patricia Chakur; Jannig, Paulo Roberto] Univ Sao Paulo, Sch Phys Educ & Sport, Cellular & Mol Exercise Physiol Lab, Sao Paulo, Brazil. [Man, Na; Wen, Longping; Zhang, Yunjiao] Univ Sci & Technol China, Hefei, Anhui, Peoples R China. [Mei, Yide] Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, Sch Lifesci, Hefei, Anhui, Peoples R China. [Shi, Qinghua] Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China. [Shi, Qinghua] Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China. [Wu, Mian] Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China. [Daza, Paula] Univ Seville, Dept Cell Biol, Seville, Spain. [Cordero, Mario D.] Univ Seville, Inst Biomed Sevilla IBIS, Dept Oral Med, Seville, Spain. [King, Jason S.] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England. [Boucher, Marie-Josee] Univ Sherbrooke, Fac Med & Sci St, Dept Med, Div Gastroenterol, Sherbrooke, PQ J1K 2R1, Canada. [Del Bello, Barbara; Maellaro, Emilia] Univ Siena, Dept Mol & Dev Med, Via Laterina 8, I-53100 Siena, Italy. [Poprawa, Izabela; Rost-Roszkowska, Magdalena] Univ Silesia, Dept Anim Histol & Embryol, Katowice, Poland. [Tan, Ming] Univ S Alabama, Mitchell Canc Inst, Mobile, AL 36688 USA. [Kumar, Sharad] Univ S Australia, Adelaide, SA 5001, Australia. [Kumar, Sharad] Ctr Canc Biol, SA Pathol, Adelaide, SA, Australia. [Morrison, Janna L.] Univ S Australia, Early Origins Adult Hlth Res Grp, Sch Pharm & Med Sci, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia. [Cui, Taixing; Fan, Daping] Univ S Carolina, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29208 USA. [Ray, Swapan K.] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29208 USA. [Baumgarner, Bradley L.] Univers South Carolina Upstate, Dept Biol, Div Nat Sci & Engn, Spartanburg, SC USA. [Chatterjee, Saurabh] Univ S Carolina, Environm Hlth & Dis Lab, Dept Environm Hlth Sci, Columbia, SC 29208 USA. [Pattison, Scott] Univ S Dakota, Div Basic Biomed Sci, Vermillion, SD 57069 USA. [Wang, Hongmin] Univ S Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD 57069 USA. [Wang, Xuejun] Univ S Dakota, Vermillion, SD 57069 USA. [Dickey, Chad A.] Univ S Florida, Byrd Alzheimers Inst, Tampa, FL USA. [Nanjundan, Meera] Univ S Florida, Dept Cell Biol Microbiol & Mol Biol, Tampa, FL USA. [Uversky, Vladimir N.] Univ S Florida, Dept Mol Med, Tampa, FL USA. [Zhou, Shu-Feng] Univ S Florida, Dept Pharmaceut Sci, Tampa, FL USA. [Jinwal, Umesh Kumar] Univ S Florida, Dept Pharmaceut Sci, Coll Pharm, Byrd Alzheimers Inst, Tampa, FL USA. 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[Wang, Xiao-jia] Zhejiang Canc Hosp, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China. [Chen, Zhong] Zhejiang Univ, Dept Pharmacol, Coll Pharmaceut Sci, Hangzhou 310003, Zhejiang, Peoples R China. [Zheng, Xiaoxiang] Zhejiang Univ, Qiushi Acad Adv Studies, Dept Biomed Engn, Hangzhou 310003, Zhejiang, Peoples R China. [Chen, Wei] Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310003, Zhejiang, Peoples R China. [Jin, Hongchuan] Zhejiang Univ, Hangzhou 310003, Zhejiang, Peoples R China. [Lin, Fu-Cheng; Liu, Xiao-Hong] Zhejiang Univ, Inst Agr & Biotechnol, Hangzhou 310003, Zhejiang, Peoples R China. [Qian, Wen-bin] Zhejiang Univ, Inst Hematol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China. [Wang, Xiao-Wei] Zhejiang Univ, Inst Insect Sci, Hangzhou 310003, Zhejiang, Peoples R China. [Han, Feng] Zhejiang Univ, Inst Pharmacol Toxicol & Biochem Pharmaceut, Hangzhou 310003, Zhejiang, Peoples R China. [Zhang, Long] Zhejiang Univ, Inst Life Sci, Hangzhou, Zhejiang, Peoples R China. [Liu, Wei] Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310003, Zhejiang, Peoples R China. [Han, Weidong] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China. [Pan, Hongming; Sui, Xinbing] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou 310003, Zhejiang, Peoples R China. [Chen, Yongshun] Zhengzhou Univ, Affiliated Canc Hosp, Zhengzhou 450052, Peoples R China. RP Klionsky, DJ (reprint author), Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA. EM klionsky@umich.edu RI Miranda-Vizuete, Antonio/D-6927-2012; Nezis, Ioannis/I-4910-2014; Huang, Yong/C-8558-2011; Lemberg, Marius/B-8881-2016; Roue, Gael/D-4759-2014; KIHARA, AKIO/A-3802-2012; Pardo, Julian/K-6764-2014; White, Anthony/P-5596-2016; Bartel, Bonnie/D-3550-2011; Behrens, Georg/Q-4486-2016; Ghavami, Saeid/Q-8918-2016; Travassos, Leonardo/G-1925-2012; Fusco, Carmela/H-2964-2016; Fachbereich14, Dekanat/C-8553-2015; Xue, Yu/G-5929-2011; Lane, Jon/A-9320-2011; CESAM, UA/M-3762-2015; Ke, Zun-Ji/N-5689-2014; Chiong, Mario/I-1043-2013; Penalva, Miguel A/G-2295-2015; Pinton, Paolo/J-8025-2012; xia, tian/C-3158-2013; Vertessy, Beata/H-6202-2012; Tettamanti, Gianluca/E-5465-2012; Choubey, Vinay/H-3170-2015; Eric, Ghigo/N-9427-2016; Staels, Bart/N-9497-2016; Sasaki, Motoko/K-5913-2015; Saftig, Paul/A-7966-2010; Corazzari, Marco/K-6422-2016; Neves, Bruno/L-2557-2016; Becker, Christoph/L-2996-2016; Besteiro, Sebastien/F-3622-2014; Garcia-Macia, Marina/G-6622-2015; Thumm, Michael/A-8033-2015; Lopez-Otin, Carlos/C-6657-2013; King, Jason/D-6228-2011; ZHUANG, Xiaohong/J-3915-2014; Laporte, Jocelyn/H-6801-2016; Duran, Raul/E-4764-2011; Span, Paul/G-4710-2012; Lazo, Pedro /M-6435-2014; antonioli, manuela/F-5898-2015; Yu, Jun /D-8569-2015; Cenci, Simone/J-7700-2016; Milan, Enrico/J-8343-2016; Pacelli, Consiglia/J-9032-2016; Moreira, Paula/B-3608-2009; Gomez-Sanchez, Ruben/I-4908-2014; Zhang, Li/K-2447-2016; Seki, Ekihiro/K-2481-2016; Rimbach, Gerald/A-7178-2011; Buchan, Alastair/B-9095-2009; Frey, Norbert/A-9695-2010; Liu, Yule/E-5700-2010; Viola, Giampietro/I-4095-2012; Knecht, Erwin/K-2432-2014; Corti, Olga/I-4981-2016; Troncoso, Rodrigo/I-1915-2013; Lemaire, Stephane/A-3530-2008; Schwarten, Melanie/G-6407-2013; Corasaniti, Maria Tiziana/N-1332-2015; Westermann, Benedikt/H-7766-2013; Nakatogawa, Hitoshi/D-5155-2015; Digard, Paul/B-7717-2008; Lanzi, Cinzia/J-6539-2016; Song, Jie/J-6684-2016; Dupuis, Luc/A-6981-2012; Vachova, Libuse/H-7620-2014; Oshima, Shigeru/C-9865-2015; Lezoualc'h, Frank/E-5031-2016; Rouis, Mustapha/E-4993-2016; Mami-Chouaib, Fathia/E-5267-2016; Mauvezin, Caroline/B-5803-2016; An, Zhenyi/H-9061-2016; Gotor, Cecilia/B-7173-2012; PTMS, RNEM/C-1589-2014; Chouaib, Salem/F-7939-2016; Poulton, Joanna/I-3913-2016; Schroder, Bernd/C-5504-2011; Jungbluth, Heinz/B-8893-2012; Le Cam, Laurent/O-1408-2016; Hussain, Salik/O-1687-2016; Fiorito, Filomena/O-2175-2016; Giordano, Antonio/F-1927-2010; Machado-Santelli, Glaucia /C-6775-2013; Cervia, Davide/A-8782-2010; Wang, Yitao/O-5184-2016; Li, Rui/O-7397-2016; Reichert, Andreas/A-4090-2012; Soenen, Stefaan/D-7370-2014; Tapia, Jose/C-5181-2008; Wang, Haichao/K-6310-2012; Gorski, Sharon/E-9375-2012; Munoz-Pinedo, Cristina/B-6118-2008; Vasconcelos, M. 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Sedej, Simon/L-3066-2015; Ureshino, Rodrigo/C-4095-2014; Pervaiz, Shazib/C-4188-2015; Yamanaka, Koji/H-5806-2011; Smith, Duncan /C-6891-2011; Andrieu-Abadie, Nathalie/N-6793-2013; Nunes dos Santos, Claudia/H-6476-2016; OI Miranda-Vizuete, Antonio/0000-0002-6856-5396; Nezis, Ioannis/0000-0003-0233-7574; Lemberg, Marius/0000-0002-0996-1268; Roue, Gael/0000-0003-0245-2257; KIHARA, AKIO/0000-0001-5889-0788; Pardo, Julian/0000-0003-0154-0730; White, Anthony/0000-0003-1802-9891; Bartel, Bonnie/0000-0002-6367-346X; Travassos, Leonardo/0000-0003-1323-3797; Fusco, Carmela/0000-0001-7794-6046; Xue, Yu/0000-0002-9403-6869; Ke, Zun-Ji/0000-0003-4038-2456; Chiong, Mario/0000-0002-5174-6545; Penalva, Miguel A/0000-0002-3102-2806; Pinton, Paolo/0000-0001-7108-6508; xia, tian/0000-0003-0123-1305; Tettamanti, Gianluca/0000-0002-0665-828X; Staels, Bart/0000-0002-3784-1503; Sasaki, Motoko/0000-0003-2514-760X; Corazzari, Marco/0000-0002-6246-5968; Neves, Bruno/0000-0001-7391-3124; Besteiro, Sebastien/0000-0003-1853-1494; 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Cancer Research UK [11359, 12825, 12918]; Doris Duke Charitable Foundation [2014112]; Medical Research Council [G0300648, G0601891, G0801936, G1000089, G1002186, MC_U105185860, MC_U132670600, MC_UP_A500_1019, MC_UU_12016/4, MC_UU_12022/6, MR/J010448/1, MR/L010933/1, MR/M00869X/1, MR/M019217/1, MR/N004434/1]; NCCIH NIH HHS [R01 AT005076]; NCI NIH HHS [K08 CA164047, K08 CA193982, K22 CA181274, P01 CA163200, P30 CA010815, R01 CA078810, R01 CA089121, R01 CA130893, R01 CA140964, R01 CA142862, R01 CA143811, R01 CA162405, R01 CA184137, R01 CA187305, R01 CA193698, T32 CA009686, U54 CA149147]; NCRR NIH HHS [P20 RR024489]; NEI NIH HHS [R01 EY005681, R01 EY009083, R01 EY010199, R01 EY013434, R01 EY015537, R01 EY018884, R01 EY019643, R01 EY022633, R01 EY023512, R01 EY024327, R01 EY025362, R21 EY026207]; NHLBI NIH HHS [R56 HL122580, P01 HL129941, R01 HL056416, R01 HL059888, R01 HL071158, R01 HL072166, R01 HL072844, R01 HL079669, R01 HL098216, R01 HL107594, R01 HL117913, R01 HL126711, R01 HL130174, R01 HL130230, R01 HL130845]; NIA NIH HHS [K02 AG042095, P01 AG031782, P30 AG028740, R00 AG042494, R00 AG048016, R01 AG020197, R01 AG031867, R01 AG032611, R01 AG038664, R01 AG039756, R01 AG043517, R37 AG021904]; NIAAA NIH HHS [K01 AA019996, R01 AA019954, R01 AA022601]; NIAID NIH HHS [R01 AI042999, R01 AI091968, R01 AI092084, R01 AI103197, R01 AI104928, R01 AI108906, R01 AI111935, R21 AI115286]; NIAMS NIH HHS [R01 AR042527, R01 AR050429, R01 AR060837, R01 AR062030, R21 AR060444]; NICHD NIH HHS [U54 HD090255]; NIDDK NIH HHS [K01 DK075386, K08 DK089117, P01 DK098108, P30 DK020541, P30 DK020572, P30 DK020593, R00 DK094980, R01 DK033823, R01 DK044234, R01 DK061498, R01 DK062092, R01 DK073336, R01 DK076685, R01 DK079879, R01 DK090115, R01 DK097441, R01 DK098331, R01 DK105118, R01 DK107220, R03 DK089010, R03 DK106304, R03 DK106344, R21 DK075494, R56 DK037034, R56 DK108921]; NIEHS NIH HHS [P30 ES006694, P30 ES023512]; NIGMS NIH HHS [GM053396, K12 GM068524, P20 GM103492, P20 GM103554, P20 GM103652, P20 GM104934, R01 GM021841, R01 GM053396, R01 GM060574, R01 GM061766, R01 GM063075, R01 GM101056, R01 GM114840, R01 GM116908]; NINDS NIH HHS [K08 NS083739, K08 NS085324, R01 NS062792, R01 NS073813, R01 NS075685, R01 NS076896, R01 NS077239, R01 NS078072, R01 NS079697, R01 NS085070, R01 NS088192, R01 NS089737, R01 NS091218, R01 NS094527, R03 NS090939, R21 NS091928]; Parkinson's UK [F-1002, H-1201, K-1202]; Wellcome Trust [087518]; Worldwide Cancer Research [14-1328] NR 2174 TC 332 Z9 341 U1 544 U2 899 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1554-8627 EI 1554-8635 J9 AUTOPHAGY JI Autophagy PY 2016 VL 12 IS 1 BP 1 EP 222 DI 10.1080/15548627.2015.1100356 PG 222 WC Cell Biology SC Cell Biology GA DI6FU UT WOS:000373595400001 PM 26799652 ER PT J AU Smith, AMS Talhelm, AF Kolden, CA Newingham, BA Adams, HD Cohen, JD Yedinak, KM Kremens, RL AF Smith, Alistair M. S. Talhelm, Alan F. Kolden, Crystal A. Newingham, Beth A. Adams, Henry D. Cohen, Jack D. Yedinak, Kara M. Kremens, Robert L. TI The ability of winter grazing to reduce wildfire size and fire-induced plant mortality was not demonstrated: a comment on Davies et al. (2015) SO INTERNATIONAL JOURNAL OF WILDLAND FIRE LA English DT Article DE intensity; severity; thermocouples ID BROMUS-TECTORUM; GREAT-BASIN; SAGEBRUSH STEPPE; ECOSYSTEMS; GRASSLANDS; BUNCHGRASSES; RANGELANDS; DIVERSITY; DOMINANCE; BEHAVIOR AB A recent study by Davies et al. sought to test whether winter grazing could reduce wildfire size, fire behaviour and intensity metrics, and fire-induced plant mortality in shrub-grasslands. The authors concluded that ungrazed rangelands may experience fire-induced mortality of native perennial bunchgrasses. The authors also presented several statements regarding the benefits of winter grazing on post-fire plant community responses. However, we contend that the study by Davies et al. has underlying methodological errors, lacks data necessary to support their conclusions, and does not provide a thorough discussion on the effect of grazing on rangeland ecosystems. Importantly, Davies et al. presented no data on the post-fire mortality of the perennial bunchgrasses or on the changes in plant community composition following their experimental fires. Rather, Davies et al. inferred these conclusions based on their observed fire behaviour metrics of maximum temperature and a term described as the heat load'. However, we contend that neither metric is appropriate for describing the heat flux impacts on plants. This lack of post-fire data, several methodological errors and the use of inappropriate thermal metrics limit the authors' ability to support their stated conclusions. C1 [Smith, Alistair M. S.; Yedinak, Kara M.] Univ Idaho, Idaho Fire Initiat Res & Educ, 975 West 6th St, Moscow, ID 83844 USA. [Smith, Alistair M. S.; Talhelm, Alan F.; Yedinak, Kara M.] Univ Idaho, Dept Forest Rangeland & Fire Sci, 975 West 6th St, Moscow, ID 83844 USA. [Talhelm, Alan F.] US Environm Protect Agcy, Natl Ctr Environm Assessment, Oak Ridge Inst Sci Educ, Res Triangle Pk, NC USA. [Kolden, Crystal A.] Univ Idaho, Dept Geog, 875 Perimeter Dr, Moscow, ID 83844 USA. [Newingham, Beth A.] USDA ARS, Great Basin Rangelands Res Unit, 920 Valley Rd, Reno, NV 89512 USA. [Adams, Henry D.] Oklahoma State Univ, Dept Bot, 104 Life Sci Bldg E, Stillwater, OK 74078 USA. [Cohen, Jack D.] US Forest Serv, Missoula Fire Sci Lab, 7557 West Broadway St, Missoula, MT 59808 USA. [Kremens, Robert L.] Rochester Inst Technol, Coll Sci, Gosnell Hall 84, Rochester, NY 14623 USA. RP Smith, AMS (reprint author), Univ Idaho, Idaho Fire Initiat Res & Educ, 975 West 6th St, Moscow, ID 83844 USA.; Smith, AMS (reprint author), Univ Idaho, Dept Forest Rangeland & Fire Sci, 975 West 6th St, Moscow, ID 83844 USA. EM alistair@uidaho.edu NR 41 TC 2 Z9 2 U1 3 U2 7 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1049-8001 EI 1448-5516 J9 INT J WILDLAND FIRE JI Int. J. Wildland Fire PY 2016 VL 25 IS 4 BP 484 EP 488 DI 10.1071/WF15163 PG 5 WC Forestry SC Forestry GA DI7VF UT WOS:000373709400012 ER PT J AU Yelverton, TLB Nash, DG Brown, JE Singer, CF Ryan, JV Kariher, PH AF Yelverton, Tiffany L. B. Nash, David G. Brown, James E. Singer, Carl F. Ryan, Jeffrey V. Kariher, Peter H. TI Dry sorbent injection of trona to control acid gases from a pilot-scale coal-fired combustion facility SO AIMS ENVIRONMENTAL SCIENCE LA English DT Article DE coal combustion; acid gases; dry sorbent injection (DSI); trona; MATS; emissions reduction ID FLUE-GAS; SO2; HEALTH; HCL AB Gaseous and particulate emissions from the combustion of coal have been associated with adverse effects on human and environmental health, and have for that reason been subject to regulation by federal and state governments. Recent regulations by the United States Environmental Protection Agency have further restricted the emissions of acid gases from electricity generating facilities and other industrial facilities, and upcoming deadlines are forcing industry to consider both pre- and post-combustion controls to maintain compliance. As a result of these recent regulations, dry sorbent injection of trona to remove acid gas emissions (e.g. HCl, SO2, and NOx) from coal combustion, specifically 90% removal of HCl, was the focus of the current investigation. Along with the measurement of HCl, SO2, and NOx, measurements of particulate matter (PM), elemental (EC), and organic carbon (OC) were also accomplished on a pilot-scale coal-fired combustion facility. Gaseous and particulate emissions from a coal-fired combustor burning bituminous coal and using dry sorbent injection were the focus of the current study. From this investigation it was shown that high levels of trona were needed to achieve the goal of 90% HCl removal, but with this increased level of trona injection the ESP and BH were still able to achieve greater than 95% fine PM control. In addition to emissions reported, measurement of acid gases by standard EPA methods were compared to those of an infrared multi-component gas analyzer. This comparison revealed good correlation for emissions of HCl and SO2, but poor correlation in the measurement of NOx emissions. C1 [Yelverton, Tiffany L. B.; Brown, James E.; Ryan, Jeffrey V.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. [Nash, David G.] US EPA, Off Air Qual Planning & Stand, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA. [Kariher, Peter H.] Jacobs Technol Inc, 600 William Northern Blvd, Tullahoma, TN 37388 USA. RP Yelverton, TLB (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. EM yelverton.tiffany@epa.gov NR 17 TC 0 Z9 0 U1 2 U2 2 PU AMER INST MATHEMATICAL SCIENCES-AIMS PI SPRINGFIELD PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA SN 2372-0344 EI 2372-0352 J9 AIMS ENVIRON SCI JI AIMS Environ. Sci. PY 2016 VL 3 IS 1 BP 45 EP 57 DI 10.3934/environsci.2016.1.45 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA DG5NT UT WOS:000372125800003 ER PT J AU Clements, AL Fraser, MP Herckes, P Solomon, PA AF Clements, Andrea L. Fraser, Matthew P. Herckes, Pierre Solomon, Paul A. TI Chemical mass balance source apportionment of fine and PM10 in the Desert Southwest, USA SO AIMS ENVIRONMENTAL SCIENCE LA English DT Article DE organic speciation; crustal material source profiles ID AIR-POLLUTION SOURCES; PARTICULATE MATTER; ORGANIC-COMPOUNDS; EMISSIONS; EVOLUTION; SAMPLES; C-1 AB The Desert Southwest Coarse Particulate Matter Study was undertaken in Pinal County, Arizona, to better understand the origin and impact of sources of fine and coarse particulate matter (PM) in rural, arid regions of the U.S. southwestern desert. The desert southwest experiences some of the highest PM10 mass concentrations in the country. To augment previously reported results, 6-week aggregated organic speciation data that included ambient concentrations of n-alkanes, polycyclic aromatic hydrocarbons, organic acids, and saccharides were used in chemical mass balance modeling (CMB). A set of re-suspended soil samples were analyzed for specific marker species to provide locally-appropriate source profiles for the CMB analysis. These profiles, as well as previously collected plant and fungal spore profiles from the region, were combined with published source profiles for other relevant sources and used in the CMB analysis. The six new region-specific source profiles included both organic and inorganic species for four crustal material sources, one plant detritus source, and one fungal spore source. Results indicate that up to half of the ambient PM2.5 was apportioned to motor vehicles with the highest regional contribution observed in the small urban center of Casa Grande. Daily levels of apportioned crustal material accounted for up to 50% of PM2.5 mass with the highest contributions observed at the sites closest to active agricultural areas. Apportioned secondary PM, biomass burning, and road dust typically contributed less than 35% as a group to the apportioned PM2.5 mass. Crustal material was the primary source apportioned to PM10 and accounted for between 50-90% of the apportioned mass. Of the other sources apportioned to PM10, motor vehicles and road dust were the largest contributors at the urban and one of the rural sites, whereas road dust and meat cooking operations were the largest contributors at the other rural site. C1 [Clements, Andrea L.] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. [Clements, Andrea L.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA. [Fraser, Matthew P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. [Herckes, Pierre] Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA. [Solomon, Paul A.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Las Vegas, NV 89119 USA. RP Fraser, MP (reprint author), Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. EM matthew.fraser@asu.edu OI Clements, Andrea/0000-0003-0764-5584 NR 23 TC 1 Z9 1 U1 7 U2 13 PU AMER INST MATHEMATICAL SCIENCES-AIMS PI SPRINGFIELD PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA SN 2372-0344 EI 2372-0352 J9 AIMS ENVIRON SCI JI AIMS Environ. Sci. PY 2016 VL 3 IS 1 BP 115 EP 132 DI 10.3934/environsci.2016.1.115 PG 18 WC Environmental Sciences SC Environmental Sciences & Ecology GA DG5NT UT WOS:000372125800007 ER PT J AU Baker, KR Kotchenruther, RA Hudman, RC AF Baker, Kirk R. Kotchenruther, Robert A. Hudman, Rynda C. TI Estimating ozone and secondary PM2.5 impacts from hypothetical single source emissions in the central and eastern United States SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Photochemical model; Ozone; PM; Single source; Source apportionment ID PHOTOCHEMICAL MODEL PERFORMANCE; POWER-PLANT PLUME; AIR-POLLUTION; SOURCE APPORTIONMENT; SENSITIVITY-ANALYSIS; GRID RESOLUTION; TEXAS; IMPLEMENTATION; CALIFORNIA; EVOLUTION AB Secondary pollutant impacts from emissions of single sources may need to be assessed to satisfy a variety of regulatory requirements including the Clean Air Act New Source Review and Prevention of Significant Deterioration programs and the National Environmental Policy Act. In this work, single source impacts on O-3 and secondary PM2.5 are estimated with annual 2011 photochemical grid model simulations where new hypothetical sources are added to the central and eastern United States with varying precursor emission rates and emission release heights. Impacts from these hypothetical sources are tracked with photochemical grid model source apportionment. Single source impacts on downwind 8-hr maximum O-3 tend to increase as emissions of NOX or VOC increase. Downwind impacts on PM2.5 sulfate and nitrate also tend to increase as emissions of SO2 and NOX increase. For all secondary pollutants, impacts from these hypothetical sources tend to decrease as distance from the source increases. However, peak impacts on O-3 and secondary PM2.5 are not at the facility fence-line but typically within 50-100 km depending on the emissions rate, precursor pollutant, and emissions release point. Downwind impacts are not uniform directionally from these sources due to varying downwind availability of chemical reactants and prevailing meteorology. Peak impacts for O-3 (similar to 15 ppb) and PM2.5 sulfate (similar to 8 mu g/m(3)) were within 50 km of these hypothetical sources and peak impacts for PM2.5 nitrate (similar to 1 mu g/m(3)) were within 125 km. The daily maximum 8-hr O-3 and maximum daily average PM2.5 sulfate and nitrate ion impacts for the new hypothetical sources modeled here are generally consistent with those reported in literature. Additional assessments of single source impacts on secondary pollutants are still needed to provide a more comprehensive assessment of different source types and source environments. Copyright (C) 2015 Turkish National Committee for Air Pollution Research and Control. Production and hosting by Elsevier B.V. All rights reserved. C1 [Baker, Kirk R.] US EPA, Res Triangle Pk, NC 27711 USA. [Kotchenruther, Robert A.] US EPA, Seattle, WA USA. [Hudman, Rynda C.] US EPA, San Francisco, CA USA. RP Baker, KR (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM baker.kirk@epa.gov NR 36 TC 0 Z9 0 U1 6 U2 14 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD JAN PY 2016 VL 7 IS 1 BP 122 EP 133 DI 10.1016/j.apr.2015.08.003 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DH1EY UT WOS:000372528400015 ER PT J AU Qiu, KY Xing, WQ Scheckel, KG Cheng, YX Zhao, ZS Ruan, XL Li, LP AF Qiu, Kunyan Xing, Weiqin Scheckel, Kirk G. Cheng, Yongxia Zhao, Zongsheng Ruan, Xinling Li, Liping TI Temporal and seasonal variations of As, Cd and Pb atmospheric deposition flux in the vicinity of lead smelters in Jiyuan, China SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Lead smelter; Atmospheric deposition; Temporal variation; Jiyuan ID TRACE-ELEMENTS; SOIL; TRANSPORT; CADMIUM; REGION; METALS AB Atmospheric deposition from non-ferrous mining and smelting is one of the dominant sources of heavy metal pollution in soil. Jiyuan City in Henan Province, China produces about 900 000 tonnes of lead annually. Heavy metal soil contamination and elevated blood lead levels (BLLs) of local children in Jiyuan have been reported. This work investigated As, Cd and Pb deposition fluxes over 17 consecutive months at collection sites about 1000 m from a major lead smelter in Jiyuan. Mean As, Cd and Pb deposition fluxes were 17.2, 3.45 and 88.8 mg/m(2)/(30 d), respectively, lower values occurred from July to September during the traditional rainy season. Decreasing deposition fluxes of Cd and Pb were observed during the 17 month period, while As increased in the same period. Deposition fluxes of As, Cd and Pb of the sites near the smelter were 22.6, 29.2 and 29.4 times of those of a clean background site (0.762, 0.118 and 3.03 mg/m(2)/(30 d), respectively) far away from the smelter. Annually, the deposition enriches agricultural soil (0e20 cm plow zone) at the sampling sites with 0.805, 0.161 and 4.16 mg/kg As, Cd and Pb, respectively. Copyright (C) 2015 Turkish National Committee for Air Pollution Research and Control. Production and hosting by Elsevier B.V. All rights reserved. C1 [Qiu, Kunyan; Cheng, Yongxia; Zhao, Zongsheng] Environm Monitoring Stn Jiyuan City, Jiyuan 459000, Henan, Peoples R China. [Xing, Weiqin; Li, Liping] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Ruan, Xinling] Henan Univ, Coll Environm & Planning, Kaifeng 475004, Henan, Peoples R China. RP Li, LP (reprint author), Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China. EM li-liping@qq.com OI Scheckel, Kirk/0000-0001-9326-9241 FU National Natural Science Foundation of China [41471253]; EPA FX This work was sponsored by National Natural Science Foundation of China (no. 41471253). Although EPA contributed to this article, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. NR 31 TC 0 Z9 0 U1 5 U2 9 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD JAN PY 2016 VL 7 IS 1 BP 170 EP 179 DI 10.1016/j.apr.2015.09.003 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DH1EY UT WOS:000372528400021 ER PT J AU Winterton, SL Hardy, NB Gaimari, SD Hauser, M Hill, HN Holston, KC Irwin, ME Lambkin, CL Metz, MA Turco, F Webb, D Yang, LL Yeates, DK Wiegmann, BM AF Winterton, Shaun L. Hardy, Nate B. Gaimari, Stephen D. Hauser, Martin Hill, Hilary N. Holston, Kevin C. Irwin, Michael E. Lambkin, Christine L. Metz, Mark A. Turco, Federica Webb, Donald Yang, Longlong Yeates, David K. Wiegmann, Brian M. TI The phylogeny of stiletto flies (Diptera: Therevidae) SO SYSTEMATIC ENTOMOLOGY LA English DT Article ID HIGHER-LEVEL PHYLOGENY; LYNEBORG DIPTERA; AUSTRALIA DIPTERA; ANABARHYNCHUS MACQUART; XESTOMYZINAE DIPTERA; NANEXILA WINTERTON; TAENOGERA KROBER; BONJEANIA IRWIN; ACUPALPA KROBER; GENE-SEQUENCES AB The therevoid clade represents a group of four families (Apsilocephalidae, Evocoidae, Scenopinidae and Therevidae) of lower brachyceran Diptera in the superfamily Asiloidea. The largest of these families is that of the stiletto flies (Therevidae). A large-scale (i.e. supermatrix) phylogeny of Therevidae is presented based on DNA sequence data from seven genetic loci (16S, 18S and 28S ribosomal DNA and four protein-encoding genes: elongation factor 1-alpha, triose phosphate isomerase, short-wavelength rhodopsin and the CPSase region of carbamoyl-phosphate synthase-aspartate transcarbamoylase-dihydroorotase). Results are presented from Bayesian phylogenetic analyses of approximately 8.7 kb of sequence data for 204 taxa representing all subfamilies and genus groups of Therevidae. Our results strongly support the sister-group relationship between Therevidae and Scenopinidae, with Apsilocephalidae as sister to Evocoidae. Previous estimates of stiletto fly phylogeny based on morphology or DNA sequence data, or supertree analysis, have failed to find significant support for relationships among subfamilies. We report for the first time strong support for the placement of the subfamily Phycinae as sister to the remaining Therevidae, originating during the Mid Cretaceous. As in previous studies, the sister-group relationship between the species-rich subfamilies Agapophytinae and Therevinae is strongly supported. Agapophytinae are recovered as monophyletic, inclusive of the Taenogera group. Therevinae comprise the bulk of the species richness in the family and appear to be a relatively recent and rapid radiation originating in the southern hemisphere (Australia+Antarctica+South America) during the Late Cretaceous. Genus groups are defined for all subfamilies based on these results. C1 [Winterton, Shaun L.; Gaimari, Stephen D.; Hauser, Martin] Calif Dept Food & Agr, Calif State Collect Arthropods, 3294 Meadowview Rd, Sacramento, CA 95832 USA. [Hardy, Nate B.] Auburn Univ, Dept Entomol & Plant Pathol, Auburn, AL 36849 USA. [Hill, Hilary N.] US EPA, Washington, DC 20460 USA. [Holston, Kevin C.] Swedish Museum Nat Hist, S-10405 Stockholm, Sweden. [Irwin, Michael E.; Webb, Donald] Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Lambkin, Christine L.; Turco, Federica] Queensland Museum, POB 300, Brisbane, Qld 4101, Australia. [Metz, Mark A.] Smithsonian Inst, Washington, DC 20560 USA. [Yang, Longlong] Ctr Hlth Res, CIIT, Raleigh, NC USA. [Yeates, David K.] CSIRO, Nat Res Collect Australia, Canberra, ACT, Australia. [Wiegmann, Brian M.] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. RP Winterton, SL (reprint author), Calif Dept Food & Agr, Calif State Collect Arthropods, 3294 Meadowview Rd, Sacramento, CA 95832 USA. EM wintertonshaun@gmail.com RI Yeates, David/A-9917-2008 OI Yeates, David/0000-0001-7729-6143 FU National Science Foundation (NSF) [DEB-0614213, DEB-9521925, DEB-9977958]; Schlinger Foundation; Australian Biological Resources Study [ABRS-209-48, BBR-210-40] FX Funding for this study and those that formed the basis of this work was provided by the National Science Foundation (NSF) (DEB-0614213, DEB-9521925 and DEB-9977958), the Schlinger Foundation and the Australian Biological Resources Study (ABRS-209-48, BBR-210-40). Statements and viewpoints expressed herein do not necessarily reflect the views of the NSF or ABRS. We thank the three anonymous reviewers for their useful comments on the manuscript. NR 107 TC 2 Z9 2 U1 3 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0307-6970 EI 1365-3113 J9 SYST ENTOMOL JI Syst. Entomol. PD JAN PY 2016 VL 41 IS 1 BP 144 EP 161 DI 10.1111/syen.12147 PG 18 WC Evolutionary Biology; Entomology SC Evolutionary Biology; Entomology GA DG4QS UT WOS:000372057800009 ER PT J AU King, BA Patel, R Babb, SD Hartman, AM Freeman, A AF King, Brian A. Patel, Roshni Babb, Stephen D. Hartman, Anne M. Freeman, Alison TI National and state prevalence of smoke-free rules in homes with and without children and smokers: Two decades of progress SO PREVENTIVE MEDICINE LA English DT Article DE Smoking; Tobacco smoke pollution; Child; Households; Secondhand smoke ID CROSS-SECTIONAL SURVEY; SECONDHAND SMOKE; UNITED-STATES; TOBACCO USE; EXPOSURE; NONSMOKERS; BANS AB Objective. The home is the primary source of secondhand smoke (SHS) exposure for children. We assessed national and state progress in smoke-free home (SFH) rule adoption in homes with and without children and adult smokers. Methods. Data came from the 1992-1993 and 2010-2011 Tobacco Use Supplements to the Current Population Survey, a U.S. national probability household survey. Households were defined as having a SFH rule if all household respondents aged >= 18 indicated no one was allowed to smoke inside the home at any time. Households with children were those with occupants aged <18. Smokers were those who smoked >= 100 lifetime cigarettes and now smoked "everyday" or "some days". Results. From 1992-1993 to 2010-2011, SFH rule prevalence increased from 43.0% to 83.0% (p <.05). Among households with children, SFH rules increased overall (44.9% to 88.6%), in households without smokers (59.7% to 95.0%), and households with >= 1 smokers (9.7% to 61.0%) (p <.05). Among households without children, SFH rules increased overall (40.8% to 81.1%), in households without smokers (53.4% to 90.1%), and households with >= 1 smokers (6.3% to 40.9%) (p <.05). Prevalence increased in all states, irrespective of smoker or child occupancy (p <.05). In 2010-2011, among homes with smokers and children, SFH rule prevalence ranged from 36.5% (West Virginia) to 86.8% (California). Conclusions. Considerable progress has been made adopting SFH rules, but many U.S. children continue to be exposed to SHS because their homes are not smoke-free. Further efforts to promote adoption of SFH rules are essential to protect all children from this health risk. Published by Elsevier Inc. C1 [King, Brian A.; Patel, Roshni; Babb, Stephen D.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS F-79, Atlanta, GA 30341 USA. [Hartman, Anne M.] NCI, Tobacco Control Res Branch, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Freeman, Alison] US EPA, Indoor Environm Div, Washington, DC 20460 USA. RP King, BA (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS F-79, Atlanta, GA 30341 USA. EM baking@cdc.gov FU Intramural CDC HHS [CC999999] NR 37 TC 2 Z9 2 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD JAN PY 2016 VL 82 BP 51 EP 58 DI 10.1016/j.ypmed.2015.11.010 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA DG2WY UT WOS:000371932600008 PM 26601642 ER PT J AU Hilborn, ED Ward, RA AF Hilborn, Elizabeth D. Ward, Richard A. TI The Risk of Cyanobacterial Toxins in Dialysate: What Do We Know? SO SEMINARS IN DIALYSIS LA English DT Editorial Material ID MICROCYSTINS; EXPOSURE; BRAZIL; WATER; INTOXICATION; CYANOTOXINS; CARUARU; HEALTH; LR AB Surface waters are increasingly contaminated by cyanobacteria, which may produce potent cyanotoxins harmful to animals and humans. Hemodialysis patients are at high risk of injury from waterborne contaminants in the water used to prepare dialysate. Episodes of acute illness and death among hemodialysis patients have been reported following exposure to dialysate prepared from drinking water contaminated with elevated concentrations of cyanotoxins. Protecting dialysis patients from these toxins is complicated by a lack of monitoring and regulation of cyanotoxins in drinking water, uncertainty as to their safe levels in dialysate, and incomplete knowledge of how well current dialysate preparation and water treatment practices remove them. Until these issues are adequately addressed, hemodialysis centers should be aware of the potential for cyanotoxins to be present in their potable water supply, particularly when it comes from surface water sources prone to cyanobacterial blooms. C1 [Hilborn, Elizabeth D.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA. RP Hilborn, ED (reprint author), US EPA, Environm Publ Hlth Div, MD 58A, Res Triangle Pk, NC 27711 USA. EM hilborn.e@epa.gov NR 27 TC 1 Z9 2 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-0959 EI 1525-139X J9 SEMIN DIALYSIS JI Semin. Dial. PD JAN-FEB PY 2016 VL 29 IS 1 BP 15 EP 18 DI 10.1111/sdi.12420 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA DG7RW UT WOS:000372282400003 PM 26288252 ER PT J AU Bowden, JH Talgo, KD Spero, TL Nolte, CG AF Bowden, Jared H. Talgo, Kevin D. Spero, Tanya L. Nolte, Christopher G. TI Assessing the Added Value of Dynamical Downscaling Using the Standardized Precipitation Index SO ADVANCES IN METEOROLOGY LA English DT Article ID REGIONAL CLIMATE MODELS; UNITED-STATES; DROUGHT; SIMULATIONS; FEEDBACKS; RESPONSES; FLOODS AB In this study, the Standardized Precipitation Index (SPI) is used to ascertain the added value of dynamical downscaling over the contiguous United States. WRF is used as a regional climate model (RCM) to dynamically downscale reanalysis fields to compare values of SPI over drought timescales that have implications for agriculture and water resources planning. The regional climate generated by WRF has the largest improvement over reanalysis for SPI correlation with observations as the drought timescale increases. This suggests that dynamically downscaled fields may be more reliable than larger-scale fields for water resource applications (e.g., water storage within reservoirs). WRF improves the timing and intensity of moderate to extreme wet and dry periods, even in regions with homogenous terrain. This study also examines changes in SPI from the extreme drought of 1988 and three "drought busting" tropical storms. Each of those events illustrates the importance of using downscaling to resolve the spatial extent of droughts. The analysis of the "drought busting" tropical storms demonstrates that while the impact of these storms on ending prolonged droughts is improved by the RCM relative to the reanalysis, it remains underestimated. These results illustrate the importance and some limitations of using RCMs to project drought. C1 [Bowden, Jared H.; Talgo, Kevin D.] Univ N Carolina, Inst Environm, 100 Europa Dr,Campus Box 1105 27599-1105, Chapel Hill, NC 27517 USA. [Spero, Tanya L.; Nolte, Christopher G.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. RP Bowden, JH (reprint author), Univ N Carolina, Inst Environm, 100 Europa Dr,Campus Box 1105 27599-1105, Chapel Hill, NC 27517 USA. EM jhbowden@unc.edu RI Nolte, Christopher/H-4345-2012 OI Nolte, Christopher/0000-0001-5224-9965 FU U.S. Environmental Protection Agency through Office of Research and Development FX The PRISM precipitation analyses are courtesy of the PRISM Climate Group at Oregon State University and were obtained from http://www.prism.oregonstate.edu/. The authors thank Lara Reynolds (CSC) for assistance in developing the simulations that were used in this analysis. Valuable discussions with Ryan Boyles (State Climatologist of North Carolina) contributed to the formulation of this research concept. The authors thank Brian Eder (U.S. EPA) and the anonymous reviewer for their technical reviews of this paper. The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency's administrative review and approved for publication. NR 38 TC 1 Z9 1 U1 1 U2 4 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-9309 EI 1687-9317 J9 ADV METEOROL JI Adv. Meteorol. PY 2016 AR 8432064 DI 10.1155/2016/8432064 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF7MF UT WOS:000371541100001 ER PT J AU Riedel, TP Lin, YH Zhang, Z Chu, K Thornton, JA Vizuete, W Gold, A Surratt, JD AF Riedel, T. P. Lin, Y. -H. Zhang, Z. Chu, K. Thornton, J. A. Vizuete, W. Gold, A. Surratt, J. D. TI Constraining condensed-phase formation kinetics of secondary organic aerosol components from isoprene epoxydiols SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID REACTIVE UPTAKE; ATMOSPHERIC AEROSOLS; OXIDATION-PRODUCTS; RELATIVE-HUMIDITY; PARTICLE-PHASE; GAS; MODEL; PHOTOOXIDATION; EPOXIDES; ACIDITY AB Isomeric epoxydiols from isoprene photooxidation (IEPOX) have been shown to produce substantial amounts of secondary organic aerosol (SOA) mass and are therefore considered a major isoprene-derived SOA precursor. Heterogeneous reactions of IEPOX on atmospheric aerosols form various aerosol-phase components or "tracers" that contribute to the SOA mass burden. A limited number of the reaction rate constants for these acid-catalyzed aqueous-phase tracer formation reactions have been constrained through bulk laboratory measurements. We have designed a chemical box model with multiple experimental constraints to explicitly simulate gas-and aqueous-phase reactions during chamber experiments of SOA growth from IEPOX uptake onto acidic sulfate aerosol. The model is constrained by measurements of the IEPOX reactive uptake coefficient, IEPOX and aerosol chamber wall losses, chamber-measured aerosol mass and surface area concentrations, aerosol thermodynamic model calculations, and offline filter-based measurements of SOA tracers. By requiring the model output to match the SOA growth and offline filter measurements collected during the chamber experiments, we derive estimates of the tracer formation reaction rate constants that have not yet been measured or estimated for bulk solutions. C1 [Riedel, T. P.; Lin, Y. -H.; Zhang, Z.; Chu, K.; Vizuete, W.; Gold, A.; Surratt, J. D.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Thornton, J. A.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Riedel, T. P.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Lin, Y. -H.] Univ Michigan, Michigan Soc Fellows, Dept Chem, Ann Arbor, MI 48109 USA. RP Surratt, JD (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. EM surratt@unc.edu RI Thornton, Joel/C-1142-2009; OI Thornton, Joel/0000-0002-5098-4867; vizuete, william/0000-0002-1399-2948 FU Environmental Protection Agency (EPA) [R835404]; National Science Foundation [CHE 1404644, CHE 1404573]; Texas Commission on Environmental Quality (TCEQ) FX This publication was made possible in part by Environmental Protection Agency (EPA) grant no. R835404. Its contents are solely the responsibility of the grantee and do not necessarily represent the official views of the EPA. Further, the EPA does not endorse the purchase of any commercial products or services mentioned in the publication. This work is also funded in part by the National Science Foundation under CHE 1404644 and CHE 1404573 and through a grant from the Texas Commission on Environmental Quality (TCEQ), administered by The University of Texas through the Air Quality Research Program. The contents, findings, opinions, and conclusions are the work of the authors and do not necessarily represent findings, opinions, or conclusions of the TCEQ. The authors also thank Tianqu Cui and Sri Hapsari Budisulistiorini (UNC) and Felipe Lopez-Hilfiker (UW) for helpful discussions. NR 41 TC 6 Z9 6 U1 6 U2 20 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PY 2016 VL 16 IS 3 BP 1245 EP 1254 DI 10.5194/acp-16-1245-2016 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF3YI UT WOS:000371284100003 ER PT J AU Marais, EA Jacob, DJ Jimenez, JL Campuzano-Jost, P Day, DA Hu, W Krechmer, J Zhu, L Kim, PS Miller, CC Fisher, JA Travis, K Yu, K Hanisco, TF Wolfe, GM Arkinson, HL Pye, HOT Froyd, KD Liao, J McNeill, VF AF Marais, E. A. Jacob, D. J. Jimenez, J. L. Campuzano-Jost, P. Day, D. A. Hu, W. Krechmer, J. Zhu, L. Kim, P. S. Miller, C. C. Fisher, J. A. Travis, K. Yu, K. Hanisco, T. F. Wolfe, G. M. Arkinson, H. L. Pye, H. O. T. Froyd, K. D. Liao, J. McNeill, V. F. TI Aqueous-phase mechanism for secondary organic aerosol formation from isoprene: application to the southeast United States and co-benefit of SO2 emission controls SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID HIGH-NOX CONDITIONS; REACTIVE UPTAKE; RELATIVE-HUMIDITY; ANTHROPOGENIC EMISSIONS; 2-METHYLGLYCERIC ACID; ATMOSPHERIC AEROSOLS; MASS-SPECTROMETER; EPOXIDE FORMATION; RATE CONSTANTS; NORTH-AMERICA AB Isoprene emitted by vegetation is an important precursor of secondary organic aerosol (SOA), but the mechanism and yields are uncertain. Aerosol is prevailingly aqueous under the humid conditions typical of isoprene-emitting regions. Here we develop an aqueous-phase mechanism for isoprene SOA formation coupled to a detailed gas-phase isoprene oxidation scheme. The mechanism is based on aerosol reactive uptake coefficients (gamma) for water-soluble isoprene oxidation products, including sensitivity to aerosol acidity and nucleophile concentrations. We apply this mechanism to simulation of aircraft (SEAC(4)RS) and ground-based (SOAS) observations over the southeast US in summer 2013 using the GEOS-Chem chemical transport model. Emissions of nitrogen oxides (NOx = NO + NO2) over the southeast US are such that the peroxy radicals produced from isoprene oxidation (ISOPO2) react significantly with both NO (high-NOx pathway) and HO2 (low-NOx pathway), leading to different suites of isoprene SOA precursors. We find a mean SOA mass yield of 3.3% from isoprene oxidation, consistent with the observed relationship of total fine organic aerosol (OA) and formaldehyde (a product of isoprene oxidation). Isoprene SOA production is mainly contributed by two immediate gasphase precursors, isoprene epoxydiols (IEPOX, 58% of isoprene SOA) from the low-NOx pathway and glyoxal (28 %) from both low-and high-NOx pathways. This speciation is consistent with observations of IEPOX SOA from SOAS and SEAC4RS. Observations show a strong relationship between IEPOX SOA and sulfate aerosol that we explain as due to the effect of sulfate on aerosol acidity and volume. Isoprene SOA concentrations increase as NOx emissions decrease (favoring the low-NOx pathway for isoprene oxidation), but decrease more strongly as SO2 emissions decrease (due to the effect of sulfate on aerosol acidity and volume). The US Environmental Protection Agency (EPA) projects 2013-2025 decreases in anthropogenic emissions of 34% for NOx (leading to a 7% increase in isoprene SOA) and 48% for SO2 (35% decrease in isoprene SOA). Reducing SO2 emissions decreases sulfate and isoprene SOA by a similar magnitude, representing a factor of 2 co-benefit for PM2.5 from SO2 emission controls. C1 [Marais, E. A.; Jacob, D. J.; Zhu, L.; Travis, K.; Yu, K.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Jacob, D. J.; Kim, P. S.; Miller, C. C.] Harvard Univ, Earth & Planetary Sci, Cambridge, MA 02138 USA. [Jimenez, J. L.; Campuzano-Jost, P.; Day, D. A.; Hu, W.; Krechmer, J.; Froyd, K. D.; Liao, J.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Jimenez, J. L.; Campuzano-Jost, P.; Day, D. A.; Hu, W.; Krechmer, J.] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA. [Fisher, J. A.] Univ Wollongong, Sch Chem, Wollongong, NSW, Australia. [Fisher, J. A.] Univ Wollongong, Sch Earth & Environm Sci, Wollongong, NSW, Australia. [Hanisco, T. F.; Wolfe, G. M.] NASA, Goddard Space Flight Ctr, Atmospher Chem & Dynam Lab, Greenbelt, MD USA. [Wolfe, G. M.] Univ Maryland Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 21228 USA. [Arkinson, H. L.] Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA. [Pye, H. O. T.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Froyd, K. D.; Liao, J.] NOAA, Earth Syst Res Lab, Chem Sci Div, Boulder, CO USA. [McNeill, V. F.] Columbia Univ, Dept Chem Engn, New York, NY USA. RP Marais, EA (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. EM emarais@seas.harvard.edu RI Jimenez, Jose/A-5294-2008; Wolfe, Glenn/D-5289-2011; Travis, Katherine/G-1417-2016; Fisher, Jenny/J-3979-2012; Pye, Havala/F-5392-2012; Krechmer, Jordan/C-9153-2016; Chem, GEOS/C-5595-2014; Manager, CSD Publications/B-2789-2015; OI Jimenez, Jose/0000-0001-6203-1847; Travis, Katherine/0000-0003-1628-0353; Fisher, Jenny/0000-0002-2921-1691; Pye, Havala/0000-0002-2014-2140; Krechmer, Jordan/0000-0003-3642-0659; Marais, Eloise/0000-0001-5477-8051 FU NASA Tropospheric Chemistry Program; NASA Air Quality Applied Sciences Team; South African National Research Foundation Fellowship; Schlumberger Faculty for the Future Fellowship FX We are grateful to the entire NASA SEAC4RS team for their help in the field, in particular Paul Wennberg, John Crounse, Jason St. Clair, and Alex Teng for their CIT-CIMS measurements. Thanks also to Jesse Kroll for assisting in the interpretation of chamber study results. This work was funded by the NASA Tropospheric Chemistry Program, the NASA Air Quality Applied Sciences Team, and a South African National Research Foundation Fellowship and Schlumberger Faculty for the Future Fellowship to E. A. Marais. W. Hu, J. Krechmer, P. Campuzano-Jost, D. A. Day, and J. L. Jimenez were supported by NASA NNX12AC03G/NNX15AT96G and NSF AGS-1243354. J. Krechmer was supported by EPA STAR (FP-91770901-0) and CIRES Fellowships. J. A. Fisher acknowledges support from a University of Wollongong Vice Chancellor's Postdoctoral Fellowship. HCHO observations were acquired with support from NASA ROSES SEAC4RS grant NNH10ZDA001N. Although this document has been reviewed by US EPA and approved for publication, it does not necessarily reflect US EPA's policies or views. NR 113 TC 15 Z9 15 U1 31 U2 61 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PY 2016 VL 16 IS 3 BP 1603 EP 1618 DI 10.5194/acp-16-1603-2016 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF3YI UT WOS:000371284100025 ER PT J AU Verma, S Baig, RBN Nadagouda, MN Varma, RS AF Verma, Sanny Baig, R. B. Nasir Nadagouda, Mallikarjuna N. Varma, Rajender S. TI Visible light mediated upgrading of biomass to biofuel SO GREEN CHEMISTRY LA English DT Article ID GRAPHITIC CARBON NITRIDE; C-H ACTIVATION; FORMIC-ACID; PALLADIUM NANOPARTICLES; EFFICIENT; CATALYST; HYDROGENATION; FERMENTATION; CONVERSION; OXIDATION AB Pd and Ag nanoparticles over graphitic carbon nitride (g-C3N4) surface, AgPd@g-C3N4, serve as an efficient catalyst for upgrading of biofuel via hydrodeoxygenation of vanillin under visible light. C1 [Verma, Sanny; Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU Postgraduate Research Program at the National Risk Management Research Laboratory FX SV and RBNB were supported by the Postgraduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 29 TC 7 Z9 7 U1 12 U2 31 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 5 BP 1327 EP 1331 DI 10.1039/c5gc02951a PG 5 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DF8LA UT WOS:000371608100020 ER PT J AU Lemieux, P Wood, J Drake, J Minamyer, S Silvestri, E Yund, C Nichols, T Ierardi, M Amidan, B AF Lemieux, P. Wood, J. Drake, J. Minamyer, S. Silvestri, E. Yund, C. Nichols, T. Ierardi, M. Amidan, B. TI Analysis of waste management issues arising from a field study evaluating decontamination of a biological agent from a building SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article AB The Bio-response Operational Testing and Evaluation (BOTE) Project was a cross-government effort designed to operationally test and evaluate a response to a biological incident (release of Bacillus anthracis [Ba] spores, the causative agent for anthrax) from initial public health and law enforcement response through environmental remediation. The BOTE Project was designed to address site remediation after the release of a Ba simulant, Bacillus atrophaeus spp. globigii (Bg), within a facility, drawing upon recent advances in the biological sampling and decontamination areas. A key component of response to a biological contamination incident is the proper management of wastes and residues, which is woven throughout all response activities. Waste is generated throughout the response and includes items like sampling media packaging materials, discarded personal protective equipment, items removed from the facility either prior to or following decontamination, aqueous waste streams, and materials generated through the application of decontamination technologies. The amount of residual contaminating agent will impact the available disposal pathways and waste management costs. Waste management is an integral part of the decontamination process and should be included through "Pre-Incident" response planning. Overall, the pH-adjusted bleach decontamination process generated the most waste from the decontamination efforts, and fumigation with chlorine dioxide generated the least waste. A majority of the solid waste generated during pH-adjusted bleach decontamination was the nonporous surfaces that were removed, bagged, decontaminated ex situ, and treated as waste. The waste during the two fumigation rounds of the BOTE Project was associated mainly with sampling activities. Waste management activities may represent a significant contribution to the overall cost of the response/recovery operation. This paper addresses the waste management activities for the BOTE field test. Implications: Management of waste is a critical element of activities dealing with remediation of buildings and outdoor areas following a biological contamination incident. Waste management must be integrated into the overall remediation process, along with sampling, decontamination, resource management, and other important response elements, rather than being a stand-alone activity. The results presented in this paper will provide decision makers and emergency planners at the federal/state/tribal/local level information that can be used to integrate waste management into an overall systems approach to planning and response activities. C1 [Lemieux, P.; Wood, J.; Drake, J.; Minamyer, S.; Silvestri, E.; Yund, C.; Nichols, T.] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Ierardi, M.] US EPA, Off Resource Conservat & Recovery, Waste Characterizat Branch, Washington, DC 20460 USA. [Amidan, B.] Pacific NW Natl Lab, Appl Stat & Computat Modeling Grp, Seattle, WA USA. RP Lemieux, P (reprint author), US EPA, NHSRC, 109 TW Alexander Dr E343-06, Res Triangle Pk, NC 27711 USA. EM Lemieux.paul@epa.gov OI Wood, Joseph/0000-0001-6316-9418 NR 7 TC 0 Z9 0 U1 2 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PY 2016 VL 66 IS 1 BP 17 EP 27 DI 10.1080/10962247.2015.1096865 PG 11 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DF1HX UT WOS:000371091600003 PM 26479121 ER PT J AU Strum, M Scheffe, R AF Strum, Madeleine Scheffe, Richard TI National review of ambient air toxics observations SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID NORTH-AMERICA; UNITED-STATES; FORMALDEHYDE; VARIABILITY; BENZENE AB Ambient air observations of hazardous air pollutant (HAPs), also known as air toxics, derived from routine monitoring networks operated by states, local agencies, and tribes (SLTs), are analyzed to characterize national concentrations and risk across the nation for a representative subset of the 187 designated HAPs. Observations from the National Air Toxics Trend Sites (NATTS) network of 27 stations located in most major urban areas of the contiguous United States have provided a consistent record of HAPs that have been identified as posing the greatest risk since 2003 and have also captured similar concentration patterns of nearly 300 sites operated by SLTs. Relatively high concentration volatile organic compounds (VOCs) such as benzene, formaldehyde, and toluene exhibit the highest annual average concentration levels, typically ranging from 1 to 5 mu g/m(3). Halogenated (except for methylene chloride) and semivolatile organic compounds (SVOCs) and metals exhibit concentrations typically 2-3 orders of magnitude lower. Formaldehyde is the highest national risk driver based on estimated cancer risk and, nationally, has not exhibited significant changes in concentration, likely associated with the large pool of natural isoprene and formaldehyde emissions. Benzene, toluene, ethylbenzene, and 1,3-butadiene are ubiquitous VOC HAPs with large mobile source contributions that continue to exhibit declining concentrations over the last decade. Common chlorinated organic compounds such as ethylene dichloride and methylene chloride exhibit increasing concentrations. The variety of physical and chemical attributes and measurement technologies across 187 HAPs result in a broad range of method detection limits (MDLs) and cancer risk thresholds that challenge confidence in risk results for low concentration HAPs with MDLs near or greater than risk thresholds. From a national monitoring network perspective, the ability of the HAPs observational database to characterize the multiple pollutant and spatial scale patterns influencing exposure is severely limited and positioned to benefit by leveraging a variety of emerging measurement technologies. Implications: Ambient air toxics observation networks have limited ability to characterize the broad suite of hazardous air pollutants (HAPs) that affect exposures across multiple spatial scales. While our networks are best suited to capture major urban-scale signals of ubiquitous volatile organic compound HAPs, incorporation of sensing technologies that address regional and local-scale exposures should be pursued to address major gaps in spatial resolution. Caution should be exercised in interpreting HAPs observations based on data proximity to minimum detection limit and risk thresholds. C1 [Strum, Madeleine; Scheffe, Richard] US EPA, Durham, NC 27711 USA. RP Scheffe, R (reprint author), US EPA, RTP, C-304-02, Durham, NC 27711 USA. EM scheffe.rich@epa.gov FU Coordinating Research Council FX The authors appreciate the efforts of all anonymous reviewers to review this paper and provide suggestions, as well as those of Richard Cook, James Hemby, Mark Houyoux, Mike Koerber, and Ted Palma of the EPA. We also appreciate publications support from the Coordinating Research Council. NR 38 TC 2 Z9 2 U1 8 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PY 2016 VL 66 IS 2 BP 120 EP 133 DI 10.1080/10962247.2015.1076538 PG 14 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DF1IM UT WOS:000371093100003 PM 26230369 ER PT J AU Mancebo, U Hettiaratchi, P Jayasinghe, P Surampalli, R AF Mancebo, Uriel Hettiaratchi, Patrick Jayasinghe, Poornima Surampalli, Rao TI Determination of water retention capacity of granular media of methane biofilters: a simplified approach SO ENVIRONMENTAL EARTH SCIENCES LA English DT Article DE Methane biofilters; Water retention capacity; Granular filter media ID HYDROGEN-SULFIDE; BIOFILTRATION; COMPOST; BIODEGRADATION; PERFORMANCE; MOISTURE; TOLUENE; VAPORS; MODEL; GAS AB Methane biofilter (MBF) is a promising bioprocess technology capable of attenuating point-source and low-volume methane emissions from anthropogenic sources. Water availability is one of the most important factors affecting the growth of microorganisms; hence, water retention capacity (WRC) is a key determinant of the performance of granular filter materials when used as microbial growth media. Considering the difficulty in conducting extensive laboratory experiments to determine WRC of competing granular materials, the availability of a simple, but accurate, model for the assessment of WRC of granular materials could be an asset for practicing engineers involved in the design and operation of MBFs. This paper presents results from an assessment of the applicability of Peleg model for the estimation of WRC of granular materials that can be used as filter media in MBFs. Results show that there is high correlation between the laboratory determined water desorption values and the values predicted by Peleg model. C1 [Mancebo, Uriel; Hettiaratchi, Patrick; Jayasinghe, Poornima] Univ Calgary, Schulich Sch Engn, Dept Civil Engn, Calgary, AB T2N 1N4, Canada. [Mancebo, Uriel; Hettiaratchi, Patrick; Jayasinghe, Poornima] Univ Calgary, Schulich Sch Engn, CEERE, Calgary, AB T2N 1N4, Canada. [Surampalli, Rao] US EPA, Lenexa, KS USA. RP Hettiaratchi, P (reprint author), Univ Calgary, Schulich Sch Engn, Dept Civil Engn, Calgary, AB T2N 1N4, Canada.; Hettiaratchi, P (reprint author), Univ Calgary, Schulich Sch Engn, CEERE, Calgary, AB T2N 1N4, Canada. EM jhettiar@ucalgary.ca FU NSERC (Canada); CONACYT (Mexico) FX The authors wish to acknowledge NSERC (Canada) and CONACYT (Mexico, as a doctoral scholarship for the primary author) for financial support. The support from the Edmonton Waste Management Centre and the City of Calgary by providing the compost samples is also acknowledged. NR 24 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1866-6280 EI 1866-6299 J9 ENVIRON EARTH SCI JI Environ. Earth Sci. PD JAN PY 2016 VL 75 IS 1 AR 74 DI 10.1007/s12665-015-4907-4 PG 8 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA DD9IV UT WOS:000370239800074 ER PT J AU Baig, RBN Verma, S Nadagouda, MN Varma, RS AF Baig, R. B. Nasir Verma, Sanny Nadagouda, Mallikarjuna N. Varma, Rajender S. TI A photoactive bimetallic framework for direct aminoformylation of nitroarenes SO GREEN CHEMISTRY LA English DT Article ID GRAPHITIC CARBON NITRIDE; C-H ACTIVATION; HYDROGENATION REACTIONS; FORMIC-ACID; EFFICIENT; TEMPERATURE; AMINES; REDUCTION; OXIDATION; ALCOHOLS AB A bimetallic catalyst, AgPd@g-C3N4, synthesized by reducing silver and palladium salts over graphitic carbon nitride (g-C3N4), enables the concerted reductive formylation of aromatic nitro compounds under photo-chemical conditions using formic acid, which serves the dual role of a hydrogen source and a formylating agent. C1 [Baig, R. B. Nasir; Verma, Sanny; Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, WSWRD, WQMB, MS 443, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU U.S. Department of Energy; U.S. Environmental Protection Agency FX RBNB and SV were supported by the Postgraduate Research Program of the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 25 TC 2 Z9 2 U1 5 U2 16 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2016 VL 18 IS 4 BP 1019 EP 1022 DI 10.1039/c5gc02799c PG 4 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA DE4RM UT WOS:000370617600017 ER PT J AU Aoki, Y Brody, DJ Flegal, KM Fakhouri, THI Axelrad, DA Parker, JD AF Aoki, Yutaka Brody, Debra J. Flegal, Katherine M. Fakhouri, Tala H. I. Axelrad, Daniel A. Parker, Jennifer D. TI Blood Lead and Other Metal Biomarkers as Risk Factors for Cardiovascular Disease Mortality SO MEDICINE LA English DT Article ID ALL-CAUSE; CALCIUM; DENSITY; WOMEN AB Analyses of the Third National Health and Nutrition Examination Survey (NHANES III) in 1988 to 1994 found an association of increasing blood lead levels <10g/dL with a higher risk of cardiovascular disease (CVD) mortality. The potential need to correct blood lead for hematocrit/hemoglobin and adjust for biomarkers for other metals, for example, cadmium and iron, had not been addressed in the previous NHANES III-based studies on blood lead-CVD mortality association.We analyzed 1999 to 2010 NHANES data for 18,602 participants who had a blood lead measurement, were 40 years of age at the baseline examination and were followed for mortality through 2011. We calculated the relative risk for CVD mortality as a function of hemoglobin- or hematocrit-corrected log-transformed blood lead through Cox proportional hazard regression analysis with adjustment for serum iron, blood cadmium, serum C-reactive protein, serum calcium, smoking, alcohol intake, race/Hispanic origin, and sex.The adjusted relative risk for CVD mortality was 1.44 (95% confidence interval=1.05, 1.98) per 10-fold increase in hematocrit-corrected blood lead with little evidence of nonlinearity. Similar results were obtained with hemoglobin-corrected blood lead. Not correcting blood lead for hematocrit/hemoglobin resulted in underestimation of the lead-CVD mortality association while not adjusting for iron status and blood cadmium resulted in overestimation of the lead-CVD mortality association.In a nationally representative sample of U.S. adults, log-transformed blood lead was linearly associated with increased CVD mortality. Correcting blood lead for hematocrit/hemoglobin and adjustments for some biomarkers affected the association. C1 [Aoki, Yutaka; Brody, Debra J.; Flegal, Katherine M.; Fakhouri, Tala H. I.; Parker, Jennifer D.] Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. [Axelrad, Daniel A.] US EPA, Off Policy, Washington, DC 20460 USA. RP Aoki, Y (reprint author), Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. EM yaoki@cdc.gov NR 36 TC 3 Z9 3 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7974 EI 1536-5964 J9 MEDICINE JI Medicine (Baltimore) PD JAN PY 2016 VL 95 IS 1 AR e2223 DI 10.1097/MD.0000000000002223 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DE3ID UT WOS:000370520200008 PM 26735529 ER PT J AU Raposa, KB Chintala, M AF Raposa, Kenneth B. Chintala, Marnita TI Comparison of Bottomless Lift Nets and Breder Traps for Sampling Salt-Marsh Nekton SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID SEA-LEVEL RISE; SHALLOW ESTUARINE HABITATS; FUNDULUS-HETEROCLITUS; PHRAGMITES-AUSTRALIS; VEGETATION CHANGE; NARRAGANSETT BAY; TIDAL MARSHES; MINNOW TRAPS; RHODE-ISLAND; FISH AB Vegetated salt-marsh surfaces provide refuge, forage, and spawning habitat for estuarine nekton, yet are threatened by accelerating rates of sea-level rise in southern New England and elsewhere. Nekton responses to ongoing marsh surface changes need to be evaluated with effective and quantitative nekton sampling gear. The goal of this study was to evaluate the effectiveness of different gear for monitoring nekton in emergent salt-marsh vegetation by comparing nekton parameters between Breder traps and bottomless lift nets and between Breder traps made from different materials. Breder traps collected a significantly different nekton community, fewer species, and larger-sized Mummichogs Fundulus heteroclitus than did lift nets. Nekton community composition, richness, and the size of green crabs Carcinus maenas also differed significantly between Breder traps constructed from acrylic and wire mesh. These results show that it is not appropriate to directly compare nekton data between Breder traps and lift nets, nor between Breder traps made from different materials. Our lift-net data correspond well to other data collected with enclosure traps in southern New England. We recommend lift nets or similar enclosure traps for sampling nekton in emergent marsh vegetation and caution against using Breder traps in monitoring and assessment programs. C1 [Raposa, Kenneth B.] Narragansett Bay Natl Estuarine Res Reserve, 55 South Reserve Dr, Prudence Isl, RI 02872 USA. [Chintala, Marnita] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. RP Raposa, KB (reprint author), Narragansett Bay Natl Estuarine Res Reserve, 55 South Reserve Dr, Prudence Isl, RI 02872 USA. EM kenny@nbnerr.org FU Federal Coastal Zone Management Act; U.S. Environmental Protection Agency FX We would like to thank Tom Kutcher, Sandi Robinson, Lesa Meng, Marina Huber, Giancarlo Cicchetti, Heather Hopkins, Eric Wortman, and Samantha Hogan for help in the field and with sorting samples. We thank Robin Weber for creating Figure 1 and Suzanne Ayvazian, Rick McKinney, and G. Cicchetti for their review and comments on earlier versions of the manuscript. Financial support was provided, in part, by a grant under the Federal Coastal Zone Management Act, administered by the Office of Ocean and Coastal Management, National Oceanic and Atmospheric Administration, Silver Spring, Maryland. Mention of trade names or commercial products does not constitute endorsement or recommendation. Although the research described in this article has been funded in part by the U.S. Environmental Protection Agency, it has not been subjected to agency-level review. Therefore, it does not necessarily reflect the views of the agency. This is Office of Research and Development Tracking Number ORD-011715 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency. NR 48 TC 0 Z9 0 U1 3 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PY 2016 VL 145 IS 1 BP 163 EP 172 DI 10.1080/00028487.2015.1111254 PG 10 WC Fisheries SC Fisheries GA DE0ZP UT WOS:000370355000013 ER PT J AU Weinberg, CR AF Weinberg, Clarice R. TI Invited Commentary: Troubling Trends in Birth Weight SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Editorial Material DE birth weight; racial disparities; surrogate markers; trends AB Birth weight is a strong predictor of the health of newborns. Consequently, the report by Catov et al. in this issue of the Journal (Am J Epidemiol. 2016;183(1):15-23), in which they showed downward trends in birth weights in a Pittsburgh, Pennsylvania, hospital from 1997 to 2011, raises concerns. The widening gap reported between birth weights of babies born to white and African-American women could correspond to a widening gap in actual health outcomes. However, if the relation between birth weight and health outcomes is not causal, these trends may be epiphenomena of limited concern. C1 [Weinberg, Clarice R.] Natl Inst Environm Hlth Sci, Biostat & Computat Biol Branch, POB 12233, Res Triangle Pk, NC 27709 USA. RP Weinberg, CR (reprint author), Natl Inst Environm Hlth Sci, Biostat & Computat Biol Branch, POB 12233, Res Triangle Pk, NC 27709 USA. EM Weinber2@niehs.nih.gov NR 5 TC 1 Z9 1 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JAN 1 PY 2016 VL 183 IS 1 BP 24 EP 25 DI 10.1093/aje/kwv196 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DD5WG UT WOS:000369994800003 PM 26667252 ER PT J AU Zhao, Y Clar, JG Li, LP Xu, J Yuan, TY Bonzongo, JCJ Ziegler, KJ AF Zhao, Yang Clar, Justin G. Li, Luping Xu, Jia Yuan, Tianyu Bonzongo, Jean-Claude J. Ziegler, Kirk J. TI Selective desorption of high-purity (6,5) SWCNTs from hydrogels through surfactant modulation SO CHEMICAL COMMUNICATIONS LA English DT Article ID WALL CARBON NANOTUBES; SINGLE-CHIRALITY SEPARATION; GEL CHROMATOGRAPHY; METAL/SEMICONDUCTOR SEPARATION; AGAROSE GELS; ADSORPTION; CATALYSTS; GROWTH AB Selective desorption of (6,5) single-wall carbon nanotubes from hydrogels only occurs at specific co-surfactant ratios. High-purity fractions are obtained at this ratio even with long elution times and different total co-surfactant concentrations. These results suggest that each (n,m) type forms a thermodynamically-stable surfactant structure in the co-surfactant solution, enabling high-fidelity separations in a single column. C1 [Zhao, Yang; Li, Luping; Ziegler, Kirk J.] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. [Clar, Justin G.; Bonzongo, Jean-Claude J.] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA. [Xu, Jia; Yuan, Tianyu; Ziegler, Kirk J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Clar, Justin G.] US EPA, Off Res & Dev, Cincinnati, OH 45220 USA. RP Ziegler, KJ (reprint author), Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA.; Ziegler, KJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM kziegler@che.ufl.edu RI Yuan, Tianyu/C-8824-2017 OI Yuan, Tianyu/0000-0002-6698-5178 NR 28 TC 0 Z9 0 U1 3 U2 19 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1359-7345 EI 1364-548X J9 CHEM COMMUN JI Chem. Commun. PY 2016 VL 52 IS 14 BP 2928 EP 2931 DI 10.1039/c5cc08530f PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA DD0WI UT WOS:000369641300013 PM 26688107 ER PT S AU Gruzalski, JG Markwiese, JT Carriker, NE Rogers, WJ Vitale, RJ Thal, DI AF Gruzalski, Jacob G. Markwiese, James T. Carriker, Neil E. Rogers, William J. Vitale, Rock J. Thal, David I. BE DeVoogt, P TI Pore Water Collection, Analysis and Evolution: The Need for Standardization SO REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, VOL 237 SE Reviews of Environmental Contamination and Toxicology LA English DT Review; Book Chapter ID ACID-VOLATILE SULFIDE; SEDIMENT QUALITY CRITERIA; BIOTIC LIGAND MODEL; CONTAMINATED SEDIMENTS; TECHNICAL BASIS; FRESH-WATER; BENTHIC INVERTEBRATES; SEQUENTIAL EXTRACTION; CADMIUM ACCUMULATION; DAPHNIA-MAGNA C1 [Gruzalski, Jacob G.; Thal, David I.] Environm Stand Inc, 8331 E Walker Springs Lane,Suite 402, Knoxville, TN 37923 USA. [Markwiese, James T.] US EPA, Corvallis, OR 97333 USA. [Carriker, Neil E.] Tennessee Valley Author, Harriman, TN 37448 USA. [Rogers, William J.] Restorat Serv Inc, Oak Ridge, TN 37830 USA. [Vitale, Rock J.] Environm Stand Inc, Valley Forge, PA 19482 USA. RP Gruzalski, JG (reprint author), Environm Stand Inc, 8331 E Walker Springs Lane,Suite 402, Knoxville, TN 37923 USA. EM jgruzalski@envstd.com; jim.markwiese@gmail.com; necarriker@tva.gov; William.Rogers@ettp.doe.gov; rvitale@envstd.com; dthal@envstd.com NR 71 TC 0 Z9 0 U1 4 U2 13 PU SPRINGER INT PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 0179-5953 BN 978-3-319-23573-8; 978-3-319-23572-1 J9 REV ENVIRON CONTAM T JI Rev. Environ. Contam. Toxicol. PY 2016 VL 237 BP 37 EP 51 DI 10.1007/978-3-319-23573-8_2 D2 10.1007/978-3-319-23573-8 PG 15 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA BE2OH UT WOS:000369711200004 PM 26613987 ER PT J AU Taubel, M Karvonen, AM Reponen, T Hyvarinen, A Vesper, S Pekkanen, J AF Taubel, Martin Karvonen, Anne M. Reponen, Tiina Hyvarinen, Anne Vesper, Stephen Pekkanen, Juha TI Application of the Environmental Relative Moldiness Index in Finland SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID MOISTURE DAMAGE; BIRTH-COHORT; RESPIRATORY HEALTH; ASTHMA; HOMES; VALUES; DUST; ADULTS; FUNGI AB The environmental relative moldiness index (ERMI) metric was previously developed to quantify mold contamination in U.S. homes. This study determined the applicability of the ERMI for quantifying mold and moisture damage in Finnish residences. Homes of the LUKAS2 birth cohort in Finland were visually inspected for moisture damage and mold, and vacuumed floor dust samples were collected. An ERMI analysis including 36 mold-specific quantitative PCR assays was performed on the dust samples (n = 144), and the ERMI metric was analyzed against inspection-based observations of moisture damage and mold. Our results show that the ERMI was significantly associated with certain observations of visible mold in Finnish homes but not with moisture damage. Several mold species occurred more frequently and at higher levels in Finnish than in U.S. homes. Modification of the ERMI toward Finnish conditions, using a subsample of LUKAS2 homes with and without moisture damage, resulted in a simplified metric based on 10 mold species. The Finnish ERMI (FERMI) performed substantially better in quantifying moisture and mold damage in Finnish homes, showing significant associations with various observations of visible mold, strongest when the damage was located in the child's main living area, as well as with mold odor and moisture damage. As shown in Finland, the ERMI as such is not equally well usable in different climates and geographic regions but may be remodeled to account for local outdoor and indoor fungal conditions as well as for moisture damage characteristics in a given country. C1 [Taubel, Martin; Karvonen, Anne M.; Hyvarinen, Anne; Pekkanen, Juha] Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. [Reponen, Tiina] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA. [Reponen, Tiina] Univ Eastern Finland, Dept Environm Sci, Kuopio, Finland. [Vesper, Stephen] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Pekkanen, Juha] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland. RP Taubel, M (reprint author), Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. EM martin.taubel@thl.fi OI Pekkanen, Juha/0000-0002-1083-8777 FU European Union [QLK4-CT-2001-00250]; Graduate School in Environmental Health (SYTYKE), EVO and VTR funding; Farmers' Social Insurance Institution (Mela); Academy of Finland [139021, 287675]; Juho Vainio Foundation; Finnish Cultural Foundation; Finnish National Institute for Health and Welfare FX LUKAS2 was supported by research grants from the European Union (grant QLK4-CT-2001-00250), the Graduate School in Environmental Health (SYTYKE), EVO and VTR funding, the Farmers' Social Insurance Institution (Mela), the Academy of Finland (grants 139021 and 287675), the Juho Vainio Foundation, the Finnish Cultural Foundation, and the Finnish National Institute for Health and Welfare. NR 29 TC 0 Z9 0 U1 3 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JAN PY 2016 VL 82 IS 2 BP 578 EP 584 DI 10.1128/AEM.02785-15 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA DC7BL UT WOS:000369373200017 ER PT J AU Laurent, A Fennel, K Wilson, R Lehrter, J Devereux, R AF Laurent, A. Fennel, K. Wilson, R. Lehrter, J. Devereux, R. TI Parameterization of biogeochemical sediment-water fluxes using in situ measurements and a diagenetic model SO BIOGEOSCIENCES LA English DT Article ID GULF-OF-MEXICO; LOUISIANA CONTINENTAL-SHELF; MARINE ECOSYSTEM MODEL; DEEP-SEA SEDIMENTS; OXYGEN-CONSUMPTION; REACTIVE TRANSPORT; GENETIC ALGORITHMS; SURFACE SEDIMENTS; ORGANIC-MATTER; NORTH-ATLANTIC AB Diagenetic processes are important drivers of water column biogeochemistry in coastal areas. For example, sediment oxygen consumption can be a significant contributor to oxygen depletion in hypoxic systems, and sediment-water nutrient fluxes support primary productivity in the overlying water column. Moreover, nonlinearities develop between bottom water conditions and sediment-water fluxes due to loss of oxygen-dependent processes in the sediment as oxygen becomes depleted in bottom waters. Yet, sediment-water fluxes of chemical species are often parameterized crudely in coupled physical-biogeochemical models, using simple linear parameterizations that are only poorly constrained by observations. Diagenetic models that represent sediment biogeochemistry are available, but rarely are coupled to water column biogeochemical models because they are computationally expensive. Here, we apply a method that efficiently parameterizes sediment-water fluxes of oxygen, nitrate and ammonium by combining in situ measurements, a diagenetic model and a parameter optimization method. As a proof of concept, we apply this method to the Louisiana Shelf where high primary production, stimulated by excessive nutrient loads from the Mississippi-Atchafalaya River system, promotes the development of hypoxic bottom waters in summer. The parameterized sediment-water fluxes represent nonlinear feedbacks between water column and sediment processes at low bottom water oxygen concentrations, which may persist for long periods (weeks to months) in hypoxic systems such as the Louisiana Shelf. This method can be applied to other systems and is particularly relevant for shallow coastal and estuarine waters where the interaction between sediment and water column is strong and hypoxia is prone to occur due to land-based nutrient loads. C1 [Laurent, A.; Fennel, K.; Wilson, R.] Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada. [Lehrter, J.; Devereux, R.] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. RP Laurent, A (reprint author), Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada. EM arnaud.laurent@dal.ca RI Fennel, Katja/A-7470-2009; OI Fennel, Katja/0000-0003-3170-2331; Laurent, Arnaud/0000-0002-8545-9309 FU NOAA CSCOR [NA06N0S4780198, NA09N0S4780208]; US IOOS Coastal Ocean Modeling Testbed, NOAA NGOMEX publication [206] FX This work was supported by NOAA CSCOR grants NA06N0S4780198 and NA09N0S4780208 and the US IOOS Coastal Ocean Modeling Testbed, NOAA NGOMEX publication no. 206. NR 74 TC 1 Z9 1 U1 2 U2 15 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1726-4170 EI 1726-4189 J9 BIOGEOSCIENCES JI Biogeosciences PY 2016 VL 13 IS 1 BP 77 EP 94 DI 10.5194/bg-13-77-2016 PG 18 WC Ecology; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA DC9EN UT WOS:000369524000006 ER PT J AU Rains, MC Leibowitz, SG Cohen, MJ Creed, IF Golden, HE Jawitz, JW Kalla, P Lane, CR Lang, MW McLaughlin, DL AF Rains, M. C. Leibowitz, S. G. Cohen, M. J. Creed, I. F. Golden, H. E. Jawitz, J. W. Kalla, P. Lane, C. R. Lang, M. W. McLaughlin, D. L. TI Geographically isolated wetlands are part of the hydrological landscape SO HYDROLOGICAL PROCESSES LA English DT Editorial Material ID DEPRESSIONAL WETLANDS; FORESTED WETLANDS; UNITED-STATES; LAND-USE; CONNECTIVITY; FRAMEWORK; SYSTEMS; USA; CLASSIFICATION; HYDRODYNAMICS C1 [Rains, M. C.] Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. [Leibowitz, S. G.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. [Cohen, M. J.] Univ Florida, Sch Forest Resources & Conservat, Gainesville, FL 32611 USA. [Creed, I. F.] Univ Western Ontario, Dept Biol, London, ON N6A 5B7, Canada. [Golden, H. E.; Lane, C. R.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Jawitz, J. W.] Univ Florida, Soil & Water Sci Dept, Gainesville, FL 32611 USA. [Kalla, P.] US EPA Reg 4, Athens, GA 30606 USA. [Lang, M. W.] Univ Maryland, Dept Geog Sci, College Pk, MD 20742 USA. [McLaughlin, D. L.] Virginia Tech, Dept Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA. RP Rains, MC (reprint author), Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. EM mrains@usf.edu NR 70 TC 4 Z9 4 U1 9 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD JAN 1 PY 2016 VL 30 IS 1 BP 153 EP 160 DI 10.1002/hyp.10610 PG 8 WC Water Resources SC Water Resources GA DC3ZZ UT WOS:000369160600011 ER PT J AU Bale, AS Lee, JS AF Bale, Ambuja S. Lee, Janice S. TI An overview of butanol-induced developmental neurotoxicity and the potential mechanisms related to these observed effects SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Review DE Butanol; Developmental neurotoxicity; Mechanisms; Alcohol; Ethanol; Fetal alcohol spectrum disorder ID ASTROGLIAL CELL-PROLIFERATION; PHOSPHOLIPASE-D; TERTIARY-BUTANOL; ETHANOL; ALCOHOLS; BRAIN; RATS; INHIBITION; MOLECULE; METABOLISM AB The purpose of this article is to briefly review the published literature on the developmental neurotoxic effects, including potential mechanisms, of four butanols: n-butanol, sec-butanol, tert-butanol, isobutanol, and identify data gaps and research needs for evaluation of human health risks in this area. Exposure potential to these four butanols is considerable given the high production volume (>1 billion Ib) of n- and tert-butanol and moderate production volumes (100-500 million Ib) of sec- and isobutanol. With the impetus to derive cleaner gasoline blends, butanols are being considered for use as fuel oxygenates. Notable signs of neurotoxicity and developmental neurotoxicity have been observed in some studies where laboratory animals (rodents) were gestationally exposed to n- or tert-butanol. Mechanistic data relevant to the observed developmental neurotoxicity endpoints were also reviewed to hypothesize potential mechanisms associated with the developmental neurotoxicity outcome. Data from the related and highly characterized alcohol, ethanol, were included to examine consistencies between this compound and the four butanols. It is widely known that alcohols, including butanols, interact with several ion channels and modulate the function of these targets following both acute and chronic exposures. In addition, n- and sec-butanol have been demonstrated to inhibit fetal rat brain astroglial cell proliferation. Further, rat pups exposed to n-butanol in utero were also reported to have significant increases in brain levels of dopamine and serotonin, but decreases in serotonin levels were noted with gestational exposure to tert-butanol. tert-Butanol was reported to inhibit muscarinic receptor-stimulated phosphoinositide metabolism which has been hypothesized to be a possible target for the neurotoxic effects of ethanol during brain development. The mechanistic data for the butanols support developmental neurotoxicity that has been observed in some of the rodent studies. However, careful studies evaluating the neurobehavior of developing pups in sensitive strains, as well as characterizing the plausible mechanisms involved, need to be conducted in order to further elucidate the neurodevelopmental effects of butanols for risk evaluation. Published by Elsevier Inc. C1 [Bale, Ambuja S.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Lee, JS (reprint author), US EPA, Natl Ctr Environm Assessment, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. NR 38 TC 0 Z9 0 U1 2 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JAN-FEB PY 2016 VL 53 BP 33 EP 40 DI 10.1016/j.ntt.2015.11.006 PG 8 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA DD1JG UT WOS:000369677400005 PM 26582497 ER PT J AU Gray, LE Furr, J Tatum-Gibbs, KR Lambright, C Sampson, H Hannas, BR Wilson, VS Hotchkiss, A Foster, PMD AF Gray, Leon Earl, Jr. Furr, Johnathan Tatum-Gibbs, Katoria R. Lambright, Christy Sampson, Hunter Hannas, Bethany R. Wilson, Vickie S. Hotchkiss, Andrew Foster, Paul M. D. TI Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels SO TOXICOLOGICAL SCIENCES LA English DT Article DE anti-androgen; risk assessment; fetal male rat endocrine; dipentyl phthalate ID MALE REPRODUCTIVE DEVELOPMENT; N-BUTYL PHTHALATE; SEXUAL-DIFFERENTIATION; DI(N-BUTYL) PHTHALATE; IN-UTERO; LUTEINIZING-HORMONE; RELATIVE POTENCY; LATE-GESTATION; EXPOSURE; VINCLOZOLIN AB Phthalate esters (PEs) constitute a large class of compounds that are used for many consumer product applications. Many of the C2-C7 di-ortho PEs reduce fetal testicular hormone and gene expression levels in rats resulting in adverse effects seen later in life but it appears that relatively large reductions in fetal testosterone (T) levels and testis gene expression may be required to adversely affect reproductive development (Hannas, B. R., Lambright, C. S., Furr, J., Evans, N., Foster, P. M., Gray, E. L., and Wilson, V. S. (2012). Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 125, 544-557). The objectives of this study were (1) to model the relationships between changes in fetal male rat plasma testosterone (PT), T levels in the testis (TT), T production (PROD), and testis gene expression with the reproductive malformation rates, and (2) to quantify the "biologically relevant reductions" (BRRs) in fetal T necessary to induce adverse effects in the offspring. In the fetal experiment, Harlan Sprague-Dawley rats were dosed with dipentyl phthalate (DPeP) at 0, 11, 33, 100, and 300 mg/kg/day from gestational days (GD) 14-18 and fetal testicular T, PT levels, and T Prod and gene expression were assessed on GD 18. In the postnatal experiment, rats were dosed with DPeP from GD 8-18 and reproductive development was monitored through adulthood. The dose-response curves for TT levels (ED50 = 53 mg/kg) and T PROD (ED50 = 45 mg/kg) were similar, whereas PT was reduced at ED50 = 19 mg/kg. When the reductions in TPROD and Insl3 mRNA were compared with the postnatal effects of in utero DPeP, dose-related reproductive alterations were noted when T PROD and Insl3 mRNA were reduced by > 45% and 42%, respectively. The determination of BRR levels may enable risk assessors to utilize fetal endocrine data to help establish points of departure for quantitative risk assessments. C1 [Gray, Leon Earl, Jr.; Furr, Johnathan; Tatum-Gibbs, Katoria R.; Lambright, Christy; Hannas, Bethany R.; Wilson, Vickie S.] US EPA, Reprod Toxicol Branch,Toxicol Assessment Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Hotchkiss, Andrew] US EPA, NCEA, ORD, Washington, DC USA. [Foster, Paul M. D.] NIEHS, Natl Toxicol Program, NIH, DHHS, Res Triangle Pk, NC 27709 USA. [Sampson, Hunter] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Hannas, Bethany R.] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. RP Gray, LE (reprint author), US EPA, Reprod Toxicol Branch,Toxicol Assessment Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM gray.earl@epa.gov OI Wilson, Vickie/0000-0003-1661-8481 FU NIH [NTP/NIEHS IA RW7592285501-1] FX Supported in part by NIH NTP/NIEHS IA RW7592285501-1. NR 31 TC 2 Z9 2 U1 5 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2016 VL 149 IS 1 BP 178 EP 191 DI 10.1093/toxsci/kfv224 PG 14 WC Toxicology SC Toxicology GA DC5BA UT WOS:000369233900016 PM 26454885 ER PT J AU Golden, HE Sander, HA Lane, CR Zhao, C Price, K D'Amico, E Christensen, JR AF Golden, Heather E. Sander, Heather A. Lane, Charles R. Zhao, Chang Price, Katie D'Amico, Ellen Christensen, Jay R. TI Relative effects of geographically isolated wetlands on streamflow: a watershed-scale analysis SO ECOHYDROLOGY LA English DT Article DE geographically isolated wetlands; wetlands; hydrologic connectivity; watershed; hydrology; watershed model; spatial stream network model ID SOUTHEASTERN UNITED-STATES; SPATIAL STATISTICAL-MODELS; MOVING-AVERAGE APPROACH; HYDROLOGIC CONNECTIVITY; DEPRESSIONAL WETLAND; COASTAL-PLAIN; GULF-COAST; RUNOFF; USA; LANDSCAPE AB Geographically isolated wetlands (GIWs) are characterized as isolated' because they are embedded by uplands, though they potentially exhibit a gradient of hydrologic, biological, or chemical connections to other surface waters. In fact, recent field studies have begun to elucidate that GIWs exhibit varying degrees of hydrologic connectivity. In this study, we examine the influence of GIWs on streamflow, a potential indicator of GIW hydrologic connectivity with surface waters. We assess annual and seasonal spatially based statistical relationships between GIW characteristics (e.g. volume and extent) and streamflow across a dense network of subbasins using a hybrid modeling approach. Our method involves the Spatial Stream Network (SSN) model, which considers spatial autocorrelation of model covariates explicitly, and the Soil and Water Assessment Tool (SWAT), which predicts streamflow across a network of 579 subbasins in the lower Neuse River Basin, North Carolina, USA. Our study results suggest that GIWs, to some extent, influence streamflow. The further GIWs are from a stream, the greater their capacity to increase streamflow due to the physiographic setting, hypothesized transit times, and sequencing of watershed hydrologic connectivity in the study area. However, as the combined extent of GIWs and non-GIWs increases in subbasins, seasonal and annual streamflow decreases. Results also suggest that other landscape indicators of watershed-scale hydrology can, in aggregate with GIWs and non-GIWs, explain variations in seasonal and annual simulated streamflow. Our study findings begin to elucidate the aggregate influence of GIWs on streamflow, providing insights for future decision-making on GIW protection and management. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Golden, Heather E.; Lane, Charles R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Sander, Heather A.; Zhao, Chang] Univ Iowa, Dept Geog & Sustainabil Sci, Iowa City, IA USA. [Price, Katie] Georgia State Univ, Dept Geosci, Atlanta, GA 30303 USA. [D'Amico, Ellen] CSS Dynamac Corp, Cincinnati, OH USA. [Christensen, Jay R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. RP Golden, HE (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, 26 W Martin Luther King Dr,MS-592, Cincinnati, OH 45268 USA. EM golden.heather@epa.gov NR 83 TC 10 Z9 10 U1 9 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD JAN PY 2016 VL 9 IS 1 BP 21 EP 38 DI 10.1002/eco.1608 PG 18 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DB9EW UT WOS:000368820200003 ER PT J AU Christensen, J Nash, M Chaloud, D Pitchford, A AF Christensen, Jay Nash, Maliha Chaloud, Deborah Pitchford, Ann TI Spatial distributions of small water body types in modified landscapes: lessons from Indiana, USA SO ECOHYDROLOGY LA English DT Article DE agricultural ponds; cumulative effects; density-area curve; impoundments; spatial distribution; wetlands ID CONTERMINOUS UNITED-STATES; SIZE-DISTRIBUTION; HYDROLOGIC CONNECTIVITY; AGRICULTURAL LANDSCAPE; NITROGEN-RETENTION; ECOSYSTEM SERVICES; CONSTRUCTED PONDS; ISOLATED WETLANDS; SURFACE-WATER; RIVER-BASIN AB Because of their large numbers and biogeochemical activity, small water bodies (SWB), such as ponds and wetlands, can have substantial cumulative effects on hydrologic, biogeochemical and biological processes, yet the spatial distributions of various SWB types are often unknown, especially in modified landscapes. Using updated National Wetland Inventory data, we compare the spatial distribution of SWB types across various ecoregions and land covers within the state of Indiana. Of 203942 total SWB, 75% contain a permanent water feature and 80% of those SWB are classified as excavated or impounded ponds. Both underlying geology and human modifications influence SWB distributions. Wetlands are most prevalent in the agricultural Drift Plain and are larger with a greater range of sizes than man-made open water features. Small impoundment ponds dominate the southern forested region of the Interior Plateau. Analysis of variance of slopes from power law distributions confirms differences between SWB distributions in the Drift Plain and the Interior Plateau as well as differences between forested wetlands and diked and excavated open waters across ecoregions. SWB densities are lowest in the Corn Belt regions and in agriculture overall. SWB in urban lands tend to have higher median area than natural or agricultural lands and have intermediate densities. This analysis highlights the presence of hydrological modifications in SWB distributions, namely the potential legacy of wetland removal and pond creation practices in the state. Determining these modified distributions and patterns is the first step in understanding cumulative SWB influences on various ecological processes in modified landscapes. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Christensen, Jay] US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. [Nash, Maliha; Chaloud, Deborah; Pitchford, Ann] US EPA, ORD, NERL, ESD, Las Vegas, NV 89193 USA. RP Christensen, J (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. EM christensen.jay@epa.gov FU US Environmental Protection Agency FX The authors greatly appreciate the advice and comments from Megan Mehaffey, Charles Lane, anonymous reviewers and editors on previous drafts. This project was supported by the US Environmental Protection Agency. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy. NR 70 TC 1 Z9 1 U1 3 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD JAN PY 2016 VL 9 IS 1 BP 122 EP 137 DI 10.1002/eco.1618 PG 16 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DB9EW UT WOS:000368820200011 ER PT J AU Daniels, SL Pressman, JG Wahman, DG AF Daniels, Stephanie L. Pressman, Jonathan G. Wahman, David G. TI AFM structural characterization of drinking water biofilm under physiological conditions SO RSC ADVANCES LA English DT Article ID ATOMIC-FORCE-MICROSCOPY; NANOSCALE CHARACTERIZATION; DISTRIBUTION-SYSTEM; ESCHERICHIA-COLI; MICROBIAL CELL; SURFACES AB Due to the complexity of mixed culture drinking water biofilm, direct visual observation under in situ conditions has been challenging. In this study, atomic force microscopy (AFM) revealed the three dimensional morphology and arrangement of drinking water relevant biofilm in air and aqueous solution. Operating parameters were optimized to improve imaging of structural details for a mature biofilm in liquid. By using a soft cantilever (0.03 N m(-1)) and slow scan rate (0.5 Hz), biofilm and the structural topography of individual bacterial cells were resolved and continuously imaged in liquid without fixation of the sample, loss of spatial resolution, or sample damage. The developed methodology will allow future in situ investigations to temporally monitor structural changes in mixed culture drinking water biofilm during disinfection treatments. C1 [Daniels, Stephanie L.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Daniels, Stephanie L.; Pressman, Jonathan G.; Wahman, David G.] US EPA, Water Supply & Water Resource Div, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Wahman, DG (reprint author), US EPA, Water Supply & Water Resource Div, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM wahman.david@epa.gov NR 33 TC 0 Z9 0 U1 8 U2 20 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2016 VL 6 IS 7 BP 5812 EP 5816 DI 10.1039/c5ra20606e PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA DC0XQ UT WOS:000368941700079 ER PT J AU Spero, TL Nolte, CG Bowden, JH Mallard, MS Herwehe, JA AF Spero, Tanya L. Nolte, Christopher G. Bowden, Jared H. Mallard, Megan S. Herwehe, Jerold A. TI The Impact of Incongruous Lake Temperatures on Regional Climate Extremes Downscaled from the CMIP5 Archive Using the WRF Model SO JOURNAL OF CLIMATE LA English DT Article DE Circulation; Dynamics; Lake effects; Stationary waves; Physical Meteorology and Climatology; Mass fluxes; transport; Models and modeling; Climate models; Mesoscale models; Regional models ID UNITED-STATES; GREAT-LAKES; SIMULATIONS; SYSTEM AB The impact of incongruous lake temperatures is demonstrated using the Weather Research and Forecasting (WRF) Model to downscale global climate fields. Unrealistic lake temperatures prescribed by the default WRF configuration cause obvious biases near the lakes and also affect predicted extremes hundreds of kilometers from the lakes, especially during winter. Using these default temperatures for the Great Lakes in winter creates a thermally induced wave in the modeled monthly average sea level pressure field, which reaches southern Florida. Differences of more than 0.5 K in monthly average daily maximum 2-m temperature occur along that wave during winter. Noteworthy changes to temperature variability, precipitation, and mesoscale circulation also occur when the default method is used for downscaling. Consequently, improperly setting lake temperatures for downscaling could result in misinterpreting changes in regional climate and adversely affect applications reliant on downscaled data, even in areas remote from the lakes. C1 [Spero, Tanya L.; Nolte, Christopher G.; Herwehe, Jerold A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Bowden, Jared H.; Mallard, Megan S.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA. RP Spero, TL (reprint author), US EPA, 109 TW Alexander Dr,MD E243-01, Res Triangle Pk, NC 27711 USA. EM spero.tanya@epa.gov RI Nolte, Christopher/H-4345-2012 OI Nolte, Christopher/0000-0001-5224-9965 FU U.S. EPA through its Office of Research and Development FX CESM data were obtained from the Earth System Grid (http://www.earthsystemgrid.org). Buoy observations were obtained from the NOAA National Data Buoy Center (http://www.ndbc.noaa.gov). The WRF Model was obtained from the National Center for Atmospheric Research (http://www.wrf-model.org). Russ Bullock and Rohit Mathur from the United States Environmental Protection Agency (U.S. EPA) provided technical feedback on this paper. The critique of three anonymous reviewers served to strengthen this manuscript. The U.S. EPA through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency's administrative review and approved for publication. NR 34 TC 1 Z9 1 U1 5 U2 15 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8755 EI 1520-0442 J9 J CLIMATE JI J. Clim. PD JAN PY 2016 VL 29 IS 2 BP 839 EP 853 DI 10.1175/JCLI-D-15-0233.1 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DB6QM UT WOS:000368639900002 ER PT J AU Sacks, JD Nichols, JL AF Sacks, Jason D. Nichols, Jennifer L. TI A Need for Better Studies to Identify Those Populations at Greatest Risk of a Pollutant-Related Health Effect SO JOURNAL OF PEDIATRICS LA English DT Editorial Material C1 [Sacks, Jason D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, B243-01,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Nichols, Jennifer L.] US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, Res Triangle Pk, NC 27711 USA. RP Sacks, JD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, B243-01,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM sacks.jason@epa.gov NR 11 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JAN PY 2016 VL 168 BP 11 EP 13 DI 10.1016/j.jpeds.2015.09.065 PG 4 WC Pediatrics SC Pediatrics GA DB5ZK UT WOS:000368592500006 PM 26490125 ER PT J AU Fout, GS Cashdollar, JL Griffin, SM Brinkman, NE Varughese, EA Parshionikar, SU AF Fout, G. Shay Cashdollar, Jennifer L. Griffin, Shannon M. Brinkman, Nichole E. Varughese, Eunice A. Parshionikar, Sandhya U. TI EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Part III. Virus Detection by RT-qPCR SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Environmental Sciences; Issue 107; virus; waterborne; detection; occurrence; total culturable virus assay; RT-qPCR ID REVERSE-TRANSCRIPTION-PCR; HEPATITIS-A VIRUS; ACUTE GASTROINTESTINAL ILLNESS; NONDISINFECTED DRINKING-WATER; ENTERIC VIRUSES; PROPIDIUM MONOAZIDE; MURINE NOROVIRUS; SAMPLES; QUANTIFICATION; OUTBREAK AB EPA Method 1615 measures enteroviruses and noroviruses present in environmental and drinking waters. This method was developed with the goal of having a standardized method for use in multiple analytical laboratories during monitoring period 3 of the Unregulated Contaminant Monitoring Rule. Herein we present the protocol for extraction of viral ribonucleic acid ( RNA) from water sample concentrates and for quantitatively measuring enterovirus and norovirus concentrations using reverse transcription-quantitative PCR (RT-qPCR). Virus concentrations for the molecular assay are calculated in terms of genomic copies of viral RNA per liter based upon a standard curve. The method uses a number of quality controls to increase data quality and to reduce interlaboratory and intralaboratory variation. The method has been evaluated by examining virus recovery from ground and reagent grade waters seeded with poliovirus type 3 and murine norovirus as a surrogate for human noroviruses. Mean poliovirus recoveries were 20% in groundwaters and 44% in reagent grade water. Mean murine norovirus recoveries with the RT-qPCR assay were 30% in groundwaters and 4% in reagent grade water. C1 [Fout, G. Shay; Cashdollar, Jennifer L.; Griffin, Shannon M.; Brinkman, Nichole E.; Varughese, Eunice A.] US EPA, Natl Exposure Res Lab, Washington, DC 20005 USA. [Parshionikar, Sandhya U.] US EPA, Tech Serv Ctr, Off Ground Water & Drinking Water, Washington, DC USA. RP Fout, GS (reprint author), US EPA, Natl Exposure Res Lab, Washington, DC 20005 USA. EM fout.shay@epa.gov NR 40 TC 0 Z9 0 U1 4 U2 10 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JAN PY 2016 IS 107 AR e52646 DI 10.3791/52646 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DB5TV UT WOS:000368577400001 PM 26862985 ER PT J AU Wang, J Aegerter, C Xu, XG Szykman, JJ AF Wang, Jun Aegerter, Clint Xu, Xiaoguang Szykman, James J. TI Potential application of VIIRS Day/Night Band for monitoring nighttime surface PM2.5 air quality from space SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Nighttime; PM2.5; VIIRS; Day/Night Band ID AEROSOL OPTICAL-THICKNESS; PARTICULATE MATTER; MODIS; CAPABILITIES; RETRIEVALS; LIGHT; CLOUD; COAST; MASS AB A pilot study is conducted to illustrate the potential of using radiance data collected by the Day/Night Band (DNB) of the Visible Infrared Imaging Radiometer Suite (VIIRS) aboard the Suomi National Polar-orbiting Partnership (S-NPP) satellite for particulate matter (PM) air quality monitoring at night. The study focuses on the moonless and cloudless nights in Atlanta, Georgia during August-October 2012. We show with radiative transfer calculations that DNB at night is sensitive to the change of aerosols and much less sensitive to the change of water vapor in the atmosphere illuminated by common outdoor light bulbs at the surface. We further show both qualitatively that the contrast of DNB images can indicate the change of air quality at the urban scale, and quantitatively that change of light intensity during the night (as characterized by VIIRS DNB) reflects the change of surface PM2.5. Compared to four meteorological variables (u and v components of surface wind speed, surface pressure, and columnar water vapor amount) that can be obtained from surface measurements, the DNB light intensity is the only variable that shows either the largest or second largest correlation with surface PM2.5 measured at 5 different sites. A simple multivariate regression model with consideration of the change of DNB light intensity can yield improved estimate of surface PM2.5 as compared to the model with consideration of meteorological variables only. Cross validation of this DNB-based regression model shows that the estimated surface PM2.5 concentration has nearly no bias and a linear correlation coefficient (R) of 0.67 with respect to the corresponding hourly observed surface PM2.5 concentration. Furthermore, ground-based observations support that surface PM2.5 concentration at the VIIRS night overpass (similar to 1:00 am local) time is representative of daily-mean PM2.5 air quality (R = 0.82 and mean bias of -0.1 mu g m(-3)). While the potential appears promising, mapping surface PM2.5 from space with visible light at night still face various challenges and the strategies to address some of these challenges are elaborated for future studies. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wang, Jun; Aegerter, Clint; Xu, Xiaoguang] Univ Nebraska, Dept Earth & Atmospher Sci, Lincoln, NE USA. [Szykman, James J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA. RP Wang, J (reprint author), 303 Bessey Hall, Lincoln, NE 68588 USA. EM jwang7@unl.edu RI Wang, Jun/A-2977-2008 OI Wang, Jun/0000-0002-7334-0490 FU NASA Applied Science Program [NNX11AJ03G] FX This study is supported by the NASA Applied Science Program (NNX11AJ03G) managed by John A. Haynes and the Suomi-NPP program managed by Diane Wickland and Paula Bontempi. We acknowledge Mr. Zhifeng Yang for his assistance in data analysis. NR 35 TC 8 Z9 8 U1 5 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD JAN PY 2016 VL 124 BP 55 EP 63 DI 10.1016/j.atmosenv.2015.11.013 PN A PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DA5RK UT WOS:000367860000007 ER PT J AU Xing, WQ Zhang, HY Scheckel, KG Li, LP AF Xing, Weiqin Zhang, Hongyi Scheckel, Kirk G. Li, Liping TI Heavy metal and metalloid concentrations in components of 25 wheat (Triticum aestivum) varieties in the vicinity of lead smelters in Henan province, China SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Wheat grain; Cd; Pb; Henan; Lead smelting; Variety ID ACCUMULATION; CONTAMINATION; SOILS; CADMIUM; HUNAN; GRAIN; RICE AB Soil contamination and human impacts have been reported in the vicinity of lead (Pb) smelters in Henan, China. However, no information is available on crop uptake of soil contaminants near these smelters. Grains, glume, rachis, and stem/leaf samples of 25 wheat (Triticum aestivum) varieties were collected from a small, smelter-impacted agricultural area of Beishe Village, Henan Province, and were analyzed for arsenic (As), cadmium (Cd), copper (Cu), Pb, and zinc (Zn) concentrations. The study aim was to evaluate the level of contaminant uptake in wheat and ostensibly observe if specific varieties of wheat were more susceptible to uptake. The mean concentrations of As, Cd, Cu, Pb, and Zn in whole grain flour were 0.0915, 0.192, 3.22, 0.280, and 32.5 mg kg(-1), respectively. Grain concentrations of all 25 varieties for Cd as well as 16 varieties for Pb exceeded the maximum permissible concentrations (MPC) for consumption. Mean pollution indexes (MPI) (element concentration of wheat grain/MPC for As, Cd or Pb) of the grains varied 0.562-2.15. As, Pb, and Cd contributed 5.22, 40.0, and 54.8 % to the MPI for all 25 varieties, respectively. This survey highlights Cd and Pb contamination of wheat grains in the vicinity of lead smelters in Henan Province, and likely other farm villages in the area. Further work is needed to examine uptake and contamination of other crops and vegetables impacted from the lead smelters in Henan Province and the absorption of toxic elements from food sources by local inhabitants. C1 [Xing, Weiqin; Zhang, Hongyi; Li, Liping] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. RP Li, LP (reprint author), Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China. EM li_liping@yahoo.com OI Scheckel, Kirk/0000-0001-9326-9241 FU National Natural Science Foundation of China [41471253]; EPA FX This work was sponsored by National Natural Science Foundation of China (41471253). The authors also want to thank Lin Li, Yali Wang, Huiyang Tian, and Xiaoxue Zhao for their help in collection and chemical analysis of the samples. Although EPA contributed to this article, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. NR 26 TC 0 Z9 0 U1 11 U2 32 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD JAN PY 2016 VL 188 IS 1 AR 23 DI 10.1007/s10661-015-5023-3 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA5ZG UT WOS:000367880700023 PM 26661959 ER PT J AU Brooks, BW Lazorchak, JM Howard, MDA Johnson, MVV Morton, SL Perkins, DAK Reavie, ED Scott, GI Smith, SA Steevens, JA AF Brooks, Bryan W. Lazorchak, James M. Howard, Meredith D. A. Johnson, Mari-Vaughn V. Morton, Steve L. Perkins, Dawn A. K. Reavie, Euan D. Scott, Geoffrey I. Smith, Stephanie A. Steevens, Jeffery A. TI Are Harmful Algal Blooms Becoming the Greatest Inland Water Quality Threat to Public Health and Aquatic Ecosystems? SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Harmful algae; Climate change; Urbanization; Agriculture; Salinization; Lake and reservoir monitoring; Toxin; Ambient toxicity; Essential services of environmental public health ID PRYMNESIUM-PARVUM BLOOMS; PERSONAL CARE PRODUCTS; CLIMATE-CHANGE; LAKE-ERIE; EUTROPHICATION; CYANOBACTERIA; BIODIVERSITY; ENVIRONMENT; QUESTIONS; IMPACTS AB In this Focus article, the authors ask a seemingly simple question: Are harmful algal blooms (HABs) becoming the greatest inland water quality threat to public health and aquatic ecosystems? When HAB events require restrictions on fisheries, recreation, and drinking water uses of inland water bodies significant economic consequences result. Unfortunately, the magnitude, frequency, and duration of HABs in inland waters are poorly understood across spatiotemporal scales and differentially engaged among states, tribes, and territories. Harmful algal bloom impacts are not as predictable as those from conventional chemical contaminants, for which water quality assessment and management programs were primarily developed, because interactions among multiple natural and anthropogenic factors determine the likelihood and severity to which a HAB will occur in a specific water body. These forcing factors can also affect toxin production. Beyond site-specific water quality degradation caused directly by HABs, the presence of HAB toxins can negatively influence routine surface water quality monitoring, assessment, and management practices. Harmful algal blooms present significant challenges for achieving water quality protection and restoration goals when these toxins confound interpretation of monitoring results and environmental quality standards implementation efforts for other chemicals and stressors. Whether HABs presently represent the greatest threat to inland water quality is debatable, though in inland waters of developed countries they typically cause more severe acute impacts to environmental quality than conventional chemical contamination events. The authors identify several timely research needs. Environmental toxicology, environmental chemistry, and risk-assessment expertise must interface with ecologists, engineers, and public health practitioners to engage the complexities of HAB assessment and management, to address the forcing factors for HAB formation, and to reduce the threats posed to inland surface water quality. (C) 2015 SETAC C1 [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. [Lazorchak, James M.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Howard, Meredith D. A.] Southern Calif Coastal Water Res Project, Costa Mesa, CA USA. [Johnson, Mari-Vaughn V.] Nat Resources Conservat Serv, USDA, Temple, TX USA. [Morton, Steve L.] NOAA, Natl Ctr Coastal Ocean Sci, Ctr Coastal Environm Hlth & Biomol Res, Charleston, SC USA. [Perkins, Dawn A. K.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. [Reavie, Euan D.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA. [Scott, Geoffrey I.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. [Smith, Stephanie A.] Beagle Bioprod, Columbus, OH USA. [Steevens, Jeffery A.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. RP Brooks, BW (reprint author), Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. EM bryan_brooks@baylor.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Lazorchak, James/0000-0002-7354-7571 FU Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada FX Permission was granted by the US Army Corps of Engineers chief of engineers to publish this material. The information in this document has been subjected to review by the USEPA, the US Department of Agriculture, and the National Oceanic and Atmospheric Administration and has been approved for publication. The views expressed in this column are those of the authors and do not necessarily represent the views or policies of the USEPA, the US Department of Agriculture, or the National Oceanic and Atmospheric Administration. During the development of this column, B.W. Brooks was supported as the Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada, and as a Visiting Erskine Fellow at the University of Canterbury, Christchurch, New Zealand. NR 48 TC 9 Z9 9 U1 51 U2 153 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 6 EP 13 DI 10.1002/etc.3220 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200001 PM 26771345 ER PT J AU Henry, T Pease, A AF Henry, Tala Pease, Anita TI In Response: A Government perspective SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Letter C1 [Henry, Tala] US EPA, Risk Assessment Div, Off Pollut Prevent & Tox, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. [Pease, Anita] US EPA, Environm Fate & Effects Div, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. RP Henry, T (reprint author), US EPA, Risk Assessment Div, Off Pollut Prevent & Tox, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 16 EP 18 DI 10.1002/etc.3196 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200004 PM 26771348 ER PT J AU Bejarano, AC Barron, MG AF Bejarano, Adriana C. Barron, Mace G. TI AQUEOUS AND TISSUE RESIDUE-BASED INTERSPECIES CORRELATION ESTIMATION MODELS PROVIDE CONSERVATIVE HAZARD ESTIMATES FOR AROMATIC COMPOUNDS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Interspecies correlation estimation; Aromatic compounds; Target lipid model; Species sensitivity distributions; Hazard concentrations ID TARGET LIPID MODEL; SPECIES SENSITIVITY DISTRIBUTIONS; NO-EFFECT CONCENTRATIONS; NARCOTIC CHEMICALS; AQUATIC ORGANISMS; TECHNICAL BASIS; TOXICITY; VALIDATION; PETROLEUM; WATER AB Interspecies correlation estimation (ICE) models were developed for 30 nonpolar aromatic compounds to allow comparison of prediction accuracy between 2 data compilation approaches. Type 1 models used data combined across studies, and type 2 models used data combined only within studies. Target lipid (TLM) ICE models were also developed using target lipid concentrations of the type 2 model dataset (type 2-TLM). Analyses were performed to assess model prediction uncertainty introduced by each approach. Most statistically significant models (90%; 266 models total) had mean square errors < 0.27 and adjusted coefficients of determination (adj R-2) > 0.59, with the lowest amount of variation in mean square errors noted for type 2-TLM followed by type 2 models. Cross-validation success (> 0.62) across most models (86% of all models) confirmed the agreement between ICE predicted and observed values. Despite differences in model predictive ability, most predicted values across all 3 ICE model types were within a 2-fold difference of the observed values. As a result, no statistically significant differences (p > 0.05) were found between most ICE-based and empirical species sensitivity distributions (SSDs). In most cases hazard concentrations were within or below the 95% confidence intervals of the direct-empirical SSD-based values, regardless of model choice. Interspecies correlation estimation-based 5th percentile (HC5) values showed a 200- to 900-fold increase as the log K-OW increased from 2 to 5.3. Results indicate that ICE models for aromatic compounds provide a statistically based approach for deriving conservative hazard estimates for protecting aquatic life. (C) 2015 SETAC C1 [Bejarano, Adriana C.] Res Planning, Columbia, SC 29202 USA. [Barron, Mace G.] US EPA, Gulf Breeze, FL USA. RP Bejarano, AC (reprint author), Res Planning, Columbia, SC 29202 USA. EM abejarano@researchplanning.com NR 39 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 56 EP 64 DI 10.1002/etc.3164 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200009 PM 26184086 ER PT J AU Wang, N Dorman, RA Ingersoll, CG Hardesty, DK Brumbaugh, WG Hammer, EJ Bauer, CR Mount, DR AF Wang, Ning Dorman, Rebecca A. Ingersoll, Christopher G. Hardesty, Doug K. Brumbaugh, William G. Hammer, Edward J. Bauer, Candice R. Mount, David R. TI ACUTE AND CHRONIC TOXICITY OF SODIUM SULFATE TO FOUR FRESHWATER ORGANISMS IN WATER-ONLY EXPOSURES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Species sensitivity; Acute-to-chronic ratio; Water composition; Major ion toxicity; Environmental guidance values ID CERIODAPHNIA-DUBIA; HYALELLA-AZTECA; DAPHNIA-MAGNA; CHLORIDE; HARDNESS; AMMONIA AB The acute and chronic toxicity of sulfate (tested as sodium sulfate) was determined in diluted well water (hardness of 100 mg/L and pH 8.2) with a cladoceran (Ceriodaphnia dubia; 2-d and 7-d exposures), a midge (Chironomus dilutus; 4-d and 41-d exposures), a unionid mussel (pink mucket, Lampsilis abrupta; 4-d and 28-d exposures), and a fish (fathead minnow, Pimephales promelas; 4-d and 34-d exposures). Among the 4 species, the cladoceran and mussel were acutely more sensitive to sulfate than the midge and fathead minnow, whereas the fathead minnow was chronically more sensitive than the other 3 species. Acute-to-chronic ratios ranged from 2.34 to 5.68 for the 3 invertebrates but were as high as 12.69 for the fish. The fathead minnow was highly sensitive to sulfate during the transitional period from embryo development to hatching in the diluted well water, and thus, additional short-term (7- to 14-d) sulfate toxicity tests were conducted starting with embryonic fathead minnow in test waters with different ionic compositions at a water hardness of 100 mg/L. Increasing chloride in test water from 10 mg Cl/L to 25 mg Cl/L did not influence sulfate toxicity to the fish, whereas increasing potassium in test water from 1mg K/L to 3mg K/L substantially reduced the toxicity of sulfate. The results indicate that both acute and chronic sulfate toxicity data, and the influence of potassium on sulfate toxicity to fish embryos, need to be considered when environmental guidance values for sulfate are developed or refined. Published 2015 SETAC. This article is a US Government work and is in the public domain in the United States. C1 [Wang, Ning; Dorman, Rebecca A.; Ingersoll, Christopher G.; Hardesty, Doug K.; Brumbaugh, William G.] US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA. [Hammer, Edward J.; Bauer, Candice R.] US EPA, Water Qual Branch, Chicago, IL USA. [Mount, David R.] US EPA, Environm Effects Res Lab, Duluth, MN USA. RP Wang, N (reprint author), US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA. EM nwang@usgs.gov FU Great Lakes Restoration Initiative FX We thank the staff in the Toxicology Branch and Environmental Chemistry Branch of the US Geological Survey, Columbia Environmental Research Center, for technical assistance. Funding for the present study was provided in part by the Great Lakes Restoration Initiative. NR 25 TC 4 Z9 4 U1 7 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 115 EP 127 DI 10.1002/etc.3148 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200015 PM 26139383 ER PT J AU Burns, FR Cogburn, LA Ankley, GT Villeneuve, DL Waits, E Chang, YJ Llaca, V Deschamps, SD Jackson, RE Hoke, RA AF Burns, Frank R. Cogburn, L. Amarin Ankley, Gerald T. Villeneuve, Daniel L. Waits, Eric Chang, Yun-Juan Llaca, Victor Deschamps, Stephane D. Jackson, Raymond E. Hoke, Robert Alan TI SEQUENCING AND DE NOVO DRAFT ASSEMBLIES OF A FATHEAD MINNOW (PIMEPHALES PROMELAS) REFERENCE GENOME SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Fathead minnow; Genome; Genetics; Ecotoxicogenomics ID MICROSATELLITE LOCI; RISK; CYPRINIDAE; MICROARRAY; ZEBRAFISH; QUALITY; FISH AB The present study was undertaken to provide the foundation for development of genome-scale resources for the fathead minnow (Pimephales promelas), an important model organism widely used in both aquatic toxicology research and regulatory testing. The authors report on the first sequencing and 2 draft assemblies for the reference genome of this species. Approximately 120x sequence coverage was achieved via Illumina sequencing of a combination of paired-end, mate-pair, and fosmid libraries. Evaluation and comparison of these assemblies demonstrate that they are of sufficient quality to be useful for genome-enabled studies, with 418 of 458 (91%) conserved eukaryotic genes mapping to at least 1 of the assemblies. In addition to its immediate utility, the present work provides a strong foundation on which to build further refinements of a reference genome for the fathead minnow. (C) 2015 SETAC C1 [Burns, Frank R.; Cogburn, L. Amarin; Hoke, Robert Alan] DuPont Co Inc, Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19714 USA. [Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. [Waits, Eric] US EPA, Cincinnati, OH 45268 USA. [Chang, Yun-Juan] Univ Illinois, High Performance Biol Comp, Urbana, IL USA. [Llaca, Victor; Deschamps, Stephane D.] DuPont Co Inc, Agr Biotechnol, Wilmington, DE USA. [Jackson, Raymond E.] DuPont Co Inc, Cent Res & Dev Biotechnol, Wilmington, DE USA. RP Hoke, RA (reprint author), DuPont Co Inc, Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19714 USA. EM robert.a.hoke@dupont.com FU USEPA Office of Research and Development Pathfinder Innovation Project Award FX We thank the University of Illinois HPCBio group for computing resources and guidance on the SOAPdenovo2 assembly, J. Simpson for assistance with the String Graph Assembler, and the Korf laboratory at the University of California at Davis for assistance with the Core Eukaryotic Genes Mapping Approach analysis. Resources to support fathead minnow inbreeding and genetic analysis and continued development of genome-scale informatics for the species were supported by a USEPA Office of Research and Development Pathfinder Innovation Project Award. The contents of the present study neither constitute nor necessarily reflect official USEPA policy. Mention of trade names or commercial products does not constitute USEPA endorsement or recommendation for use. NR 48 TC 1 Z9 1 U1 4 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 212 EP 217 DI 10.1002/etc.3186 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200026 PM 26513338 ER PT J AU Hellwinckel, C Clark, C Langholtz, M Eaton, L AF Hellwinckel, Chad Clark, Christopher Langholtz, Matthew Eaton, Laurence TI Simulated impact of the renewable fuels standard on US Conservation Reserve Program enrollment and conversion SO GLOBAL CHANGE BIOLOGY BIOENERGY LA English DT Article DE Conservation Reserve Program; Energy Independence and Security Act; land-use change; Renewable Fuel Standard; second-generation biofuels ID UNITED-STATES; SWITCHGRASS; GRASSLAND; BIOFUELS; BIOMASS; ENERGY AB A socioeconomic model is used to estimate the land-use implications on the U.S. Conservation Reserve Program from potential increases in second-generation biofuel production. A baseline scenario with no second-generation biofuel production is compared to a scenario where the Renewable Fuels Standard (RFS2) volumes are met by 2022. We allow for the possibility of converting expiring CRP lands to alternative uses such as conventional crops, dedicated second-generation biofuel crops, or harvesting existing CRP grasses for biomass. Results indicate that RFS2 volumes (RFS2-v) can be met primarily with crop residues (78% of feedstock demand) and woody residues (19% of feedstock demand) compared with dedicated biomass (3% of feedstock demand), with only minimal conversion of cropland (0.27 million hectares, <1% of total cropland), pastureland (0.28 million hectares of pastureland, <1% of total pastureland), and CRP lands (0.29 million hectares of CRP lands, 3% of existing CRP lands) to biomass production. Meeting RFS2 volumes would reduce CRP re-enrollment by 0.19 million hectares, or 4%, below the baseline scenario where RFS2 is not met. Yet under RFS2-v scenario, expiring CRP lands are more likely to be converted to or maintain perennial cover, with 1.78 million hectares of CRP lands converting to hay production, and 0.29 million hectares being harvested for existing grasses. A small amount of CRP is harvested for existing biomass, but no conversion of CRP to dedicated biomass crops, such as switchgrass, are projected to occur. Although less land is enrolled in CRP under RFS2-v scenario, total land in perennial cover increases by 0.15 million hectares, or 2%, under RFS2-v. Sensitivity to yield, payment and residue retention assumptions are evaluated. C1 [Hellwinckel, Chad] Univ Tennessee, Agr Policy Anal Ctr, Knoxville, TN 37996 USA. [Clark, Christopher] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Langholtz, Matthew; Eaton, Laurence] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. RP Hellwinckel, C (reprint author), Univ Tennessee, Agr Policy Anal Ctr, Knoxville, TN 37996 USA. EM chellwin@utk.edu RI Eaton, Laurence/E-1471-2012 OI Eaton, Laurence/0000-0003-1270-9626 FU US Environmental Protection Agency [EP-13-H-000183/0001]; US Department of Energy, Office of Science, Office of Bioenergy Technologies FX This material is based in part upon work supported by the US Environmental Protection Agency under Grant Number EP-13-H-000183/0001. This material is also based also upon work supported by the US Department of Energy, Office of Science, Office of Bioenergy Technologies. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the Environmental Protection Agency or the Department of Energy. We would also like to thank USDA Farm Service Agency for providing CRP field-level boundary information. NR 46 TC 1 Z9 1 U1 9 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1757-1693 EI 1757-1707 J9 GCB BIOENERGY JI GCB Bioenergy PD JAN PY 2016 VL 8 IS 1 BP 245 EP 256 DI 10.1111/gcbb.12281 PG 12 WC Agronomy; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA DB0BB UT WOS:000368172500021 ER PT J AU Schmitt, W Auteri, D Bastiansen, F Ebeling, M Liu, C Luttik, R Mastitsky, S Nacci, D Topping, C Wang, M AF Schmitt, Walter Auteri, Domenica Bastiansen, Finn Ebeling, Markus Liu, Chun Luttik, Robert Mastitsky, Sergey Nacci, Diane Topping, Chris Wang, Magnus TI An Example of Population-Level Risk Assessments for Small Mammals Using Individual-Based Population Models SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Individual-based model; Pesticide risk assessment; Population model; Small mammals ID MICE APODEMUS-SYLVATICUS; COMMON VOLE; PESTICIDE EXPOSURE; MICROTUS-ARVALIS; WOOD MOUSE; LANDSCAPES; DYNAMICS; ECOLOGY AB This article presents a case study demonstrating the application of 3 individual-based, spatially explicit population models (IBMs, also known as agent-based models) in ecological risk assessments to predict long-term effects of a pesticide to populations of small mammals. The 3 IBMs each used a hypothetical fungicide (FungicideX) in different scenarios: spraying in cereals (common vole, Microtus arvalis), spraying in orchards (field vole, Microtus agrestis), and cereal seed treatment (wood mouse, Apodemus sylvaticus). Each scenario used existing model landscapes, which differed greatly in size and structural complexity. The toxicological profile of FungicideX was defined so that the deterministic long-term first tier risk assessment would result in high risk to small mammals, thus providing the opportunity to use the IBMs for risk assessment refinement (i. e., higher tier risk assessment). Despite differing internal model design and scenarios, results indicated in all 3 cases low population sensitivity unless FungicideX was applied at very high (x 10) rates. Recovery from local population impacts was generally fast. Only when patch extinctions occured in simulations of intentionally high acute toxic effects, recovery periods, then determined by recolonization, were of any concern. Conclusions include recommendations for the most important input considerations, including the selection of exposure levels, duration of simulations, statistically robust number of replicates, and endpoints to report. However, further investigation and agreement are needed to develop recommendations for landscape attributes such as size, structure, and crop rotation to define appropriate regulatory risk assessment scenarios. Overall, the application of IBMs provides multiple advantages to higher tier ecological risk assessments for small mammals, including consistent and transparent direct links to specific protection goals, and the consideration of more realistic scenarios. Integr Environ Assess Manag 2016; 12: 46-57. (C) 2015 SETAC C1 [Schmitt, Walter; Ebeling, Markus] Bayer CropSci AG, Environm Safety, Monheim, Germany. [Auteri, Domenica] European Food & Safety Agcy, Pesticides Unit, Parma, Italy. [Bastiansen, Finn] Rifcon GmbH, Hirschberg, Germany. [Liu, Chun] Syngenta, Jealotts Hill Int Res Ctr, Bracknell, Berks, England. [Luttik, Robert] Almere, Almere, Netherlands. [Mastitsky, Sergey] BASF SE, Ecotoxicol, Limburgerhof, Germany. [Nacci, Diane] US EPA, Atlant Ecol Div, Populat Ecol Branch, Narragansett, RI USA. [Topping, Chris] Aarhus Univ, Dept Biosci, Ronde, Denmark. [Wang, Magnus] WSC Sci GmbH, Heidelberg, Germany. RP Schmitt, W (reprint author), Bayer CropSci AG, Environm Safety, Monheim, Germany. EM walter.schmitt@bayer.com RI Topping, Christopher/A-9167-2009; OI Topping, Christopher/0000-0003-0874-7603; Schmitt, Walter/0000-0001-6983-6525 FU BASF; Bayer CropScience; CEFIC LRI; INRA; Makthteshim AGAN; Sumitomo Chemicals; Syngenta; European Union [PITN-GA-2009-238148] FX We are grateful to SETAC and to the organizers of the MODELINK workshop for providing the opportunity for this collaboration and the development of these ideas. In particular, we thank BASF, Bayer CropScience, CEFIC LRI, INRA, Makthteshim AGAN, Sumitomo Chemicals, and Syngenta for providing funds to support the MODELINK workshop. We also thank our colleagues at that workshop for their discussions and inputs. CL has been financially supported by the European Union under the 7th Framework Programme (project acronym CREAM, contract number PITN-GA-2009-238148). NR 19 TC 1 Z9 1 U1 5 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 46 EP 57 DI 10.1002/ieam.1640 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100005 PM 25891765 ER PT J AU Powers, CM Grieger, K Meacham, CA Gooding, ML Gift, JS Lehmann, GM Hendren, CO Davis, JM Burgoon, L AF Powers, Christina M. Grieger, Khara Meacham, Connie A. Gooding, Meredith Lassiter Gift, Jeffrey S. Lehmann, Geniece M. Hendren, Christine O. Davis, J. Michael Burgoon, Lyle TI Applying Comprehensive Environmental Assessment to Research Planning for Multiwalled Carbon Nanotubes: Refinements to Inform Future Stakeholder Engagement SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Comprehensive environmental assessment; Research planning; Risk assessment; Risk management; Nanomaterials ID DECISION-ANALYSIS; HUMAN HEALTH; NANOMATERIALS; NANOTECHNOLOGY; IMPACT; RISKS AB Risk assessments and risk management efforts to protect human health and the environment can benefit from early, coordinated research planning by researchers, risk assessors, and risk managers. However, approaches for engaging these and other stakeholders in research planning have not received much attention in the environmental scientific literature. The Comprehensive Environmental Assessment (CEA) approach under development by the United States Environmental Protection Agency (USEPA) is a means to manage complex information and input from diverse stakeholder perspectives on research planning that will ultimately support environmental and human health decision making. The objectives of this article are to 1) describe the outcomes of applying lessons learned from previous CEA applications to planning research on engineered nanomaterial, multiwalled carbon nanotubes (MWCNTs) and 2) discuss new insights and refinements for future efforts to engage stakeholders in research planning for risk assessment and risk management of environmental issues. Although framed in terms of MWCNTs, this discussion is intended to enhance research planning to support assessments for other environmental issues as well. Key insights for research planning include the potential benefits of 1) ensuring that participants have research, risk assessment, and risk management expertise in addition to diverse disciplinary backgrounds; 2) including an early scoping step before rounds of formal ratings; 3) using a familiar numeric scale (e. g., US dollars) versus ordinal rating scales of "importance"; 4) applying virtual communication tools to supplement face-to-face interaction between participants; and 5) refining criteria to guide development of specific, actionable research questions. Integr Environ Assess Manag 2016; 12: 96-108. (C) 2015 SETAC C1 [Powers, Christina M.; Meacham, Connie A.; Gooding, Meredith Lassiter; Gift, Jeffrey S.; Lehmann, Geniece M.; Burgoon, Lyle] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Grieger, Khara] RTI Int, Res Triangle Pk, NC 27711 USA. [Hendren, Christine O.] Duke Univ, Ctr Environm Implicat NanoTechnol CENT, Durham, NC USA. [Davis, J. Michael] USEPA Natl Ctr Environm Assessment, Pittsboro, NC 27312 USA. RP Davis, JM (reprint author), USEPA Natl Ctr Environm Assessment, Pittsboro, NC 27312 USA. EM davis.jmichael@mindspring.com OI Burgoon, Lyle/0000-0003-4977-5352 NR 40 TC 0 Z9 0 U1 3 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 96 EP 108 DI 10.1002/ieam.1663 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100009 PM 26011822 ER PT J AU Gobas, FAPC Burkhard, LP Doucette, WJ Sappington, KG Verbruggen, EMJ Hope, BK Bonnell, MA Arnot, JA Tarazona, JV AF Gobas, Frank A. P. C. Burkhard, Lawrence P. Doucette, William J. Sappington, Keith G. Verbruggen, Eric M. J. Hope, Bruce K. Bonnell, Mark A. Arnot, Jon A. Tarazona, Jose V. TI Review of Existing Terrestrial Bioaccumulation Models and Terrestrial Bioaccumulation Modeling Needs for Organic Chemicals SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Review DE Bioaccumulation assessment; Research planning; Terrestrial bioaccumulation models ID EARTHWORMS EISENIA-ANDREI; EUROPEAN-UNION SYSTEM; NON-IONIZED CHEMICALS; FOOD-CHAIN MODEL; PLANT UPTAKE; PHYSICOCHEMICAL PROPERTIES; POLYCHLORINATED-BIPHENYLS; CONTAMINATED SOIL; COMPARTMENT MODEL; POTENTIAL RISKS AB Protocols for terrestrial bioaccumulation assessments are far less-developed than for aquatic systems. This article reviews modeling approaches that can be used to assess the terrestrial bioaccumulation potential of commercial organic chemicals. Models exist for plant, invertebrate, mammal, and avian species and for entire terrestrial food webs, including some that consider spatial factors. Limitations and gaps in terrestrial bioaccumulation modeling include the lack of QSARs for biotransformation and dietary assimilation efficiencies for terrestrial species; the lack of models and QSARs for important terrestrial species such as insects, amphibians and reptiles; the lack of standardized testing protocols for plants with limited development of plant models; and the limited chemical domain of existing bioaccumulation models and QSARs (e. g., primarily applicable to nonionic organic chemicals). There is an urgent need for high-quality field data sets for validating models and assessing their performance. There is a need to improve coordination among laboratory, field, and modeling efforts on bioaccumulative substances in order to improve the state of the science for challenging substances. Integr Environ Assess Manag 2016; 12: 123-134. (C) 2015 SETAC C1 [Gobas, Frank A. P. C.] Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada. [Burkhard, Lawrence P.] US EPA, Duluth, MN 55804 USA. [Doucette, William J.] Utah State Univ, Logan, UT 84322 USA. [Sappington, Keith G.] US EPA, Washington, DC 20460 USA. [Verbruggen, Eric M. J.] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands. [Hope, Bruce K.] CH2M Hill Inc, Portland, OR USA. [Bonnell, Mark A.] Environm Canada, Gatineau, PQ, Canada. [Arnot, Jon A.] Arnot Res & Consulting, Toronto, ON, Canada. [Tarazona, Jose V.] European Chem Agcy, Helsinki, Finland. RP Burkhard, LP (reprint author), US EPA, Duluth, MN 55804 USA. EM burkhard.lawrence@epa.gov FU International Life Sciences Institute; Health and Environmental Sciences Institute FX We thank the International Life Sciences Institute, Health and Environmental Sciences Institute for sponsoring the "Terrestrial Bioaccumulation Workshop," January 8-10, 2013 in Miami, Florida. NR 122 TC 1 Z9 1 U1 21 U2 48 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 123 EP 134 DI 10.1002/ieam.1690 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100011 PM 26272325 ER PT J AU Barber, MC Rashleigh, B Cyterski, MJ AF Barber, M. Craig Rashleigh, Brenda Cyterski, Michael J. TI Forecasting Fish Biomasses, Densities, Productions, and Bioaccumulation Potentials of Mid-Atlantic Wadeable Streams SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Bioaccumulation; Biomass; Fish; Production; Simulation modeling ID FOOD-WEB; MODELS; BIOCONCENTRATION; POPULATIONS; ASSESSMENTS; ALLOMETRY; MORTALITY; ECOSYSTEM; HABITAT; RIVERS AB Regional fishery conditions of Mid-Atlantic wadeable streams in the eastern United States are estimated using the Bioaccumulation and Aquatic System Simulator (BASS) bioaccumulation and fish community model and data collected by the US Environmental Protection Agency's Environmental Monitoring and Assessment Program (EMAP). Average annual biomasses and population densities and annual productions are estimated for 352 randomly selected streams. Realized bioaccumulation factors (BAF) and biomagnification factors (BMF), which are dependent on these forecasted biomasses, population densities, and productions, are also estimated by assuming constant water exposures to methylmercury and tetra-, penta-, hexa-, and hepta-chlorinated biphenyls. Using observed biomasses, observed densities, and estimated annual productions of total fish from 3 regions assumed to support healthy fisheries as benchmarks (eastern Tennessee and Catskill Mountain trout streams and Ozark Mountains smallmouth bass streams), 58% of the region's wadeable streams are estimated to be in marginal or poor condition (i. e., not healthy). Using simulated BAFs and EMAP Hg fish concentrations, we also estimate that approximately 24% of the game fish and subsistence fishing species that are found in streams having detectable Hg concentrations would exceed an acceptable human consumption criterion of 0.185mg/g wet wt. Importantly, such streams have been estimated to represent 78.2% to 84.4% of the Mid-Atlantic's wadeable stream lengths. Our results demonstrate how a dynamic simulation model can support regional assessment and trends analysis for fisheries. Integr Environ Assess Manag 2016; 12: 146-159. Published 2015 SETAC. This article is a US Government work and, as such, is in the public domain in the United States. C1 [Barber, M. Craig; Cyterski, Michael J.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. [Rashleigh, Brenda] US EPA, Natl Hlth & Environm Effects Lab, Atlantic Ecol Div, Narragansett, RI USA. RP Barber, MC (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. EM barber.craig@epa.gov NR 52 TC 0 Z9 0 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 146 EP 159 DI 10.1002/ieam.1644 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100013 PM 25858149 ER PT J AU Moore, DRJ Breton, RL DeLong, TR Ferson, S Lortie, JP MacDonald, DB McGrath, R Pawlisz, A Svirsky, SC Teed, RS Thompson, RP Aslund, MW AF Moore, Dwayne R. J. Breton, Roger L. DeLong, Tod R. Ferson, Scott Lortie, John P. MacDonald, Drew B. McGrath, Richard Pawlisz, Andrzej Svirsky, Susan C. Teed, R. Scott Thompson, Ryan P. Aslund, Melissa Whitfield TI Ecological Risk Assessment for Mink and Short-Tailed Shrew Exposed to PCBs, Dioxins, and Furans in the Housatonic River Area SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Housatonic River; PCBs; Probabilistic Risk Assessment; Dioxins; Furans ID POLYCHLORINATED-BIPHENYLS PCBS; TOXIC EQUIVALENCY FACTORS; FORK POPLAR CREEK; MUSTELA-VISON; DIETARY EXPOSURE; BERKSHIRE COUNTY; UNITED-STATES; AROCLOR 1254; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; MASSACHUSETTS AB A probabilistic risk assessment was conducted to characterize risks to a representative piscivorous mammal (mink, Mustela vison) and a representative carnivorous mammal (short-tailed shrew, Blarina brevicauda) exposed to PCBs, dioxins, and furans in the Housatonic River area downstream of the General Electric (GE) facility in Pittsfield, Massachusetts. Contaminant exposure was estimated using a probabilistic total daily intake model and parameterized using life history information of each species and concentrations of PCBs, dioxins, and furans in prey collected in the Housatonic River study area. The effects assessment preferentially relied on dose-response curves but defaulted to benchmarks or other estimates of effect when there were insufficient toxicity data. The risk characterization used a weight of evidence approach. Up to 3 lines of evidence were used to estimate risks to the selected mammal species: 1) probabilistic exposure and effects modeling, 2) field surveys, and 3) species-specific feeding or field studies. The weight of evidence assessment indicated a high risk for mink and an intermediate risk for short-tailed shrew. Integr Environ Assess Manag 2016; 12: 174-184. (C) 2015 SETAC C1 [Moore, Dwayne R. J.] Intrinsik Environm Sci, New Gloucester, ME 04260 USA. [Breton, Roger L.; Teed, R. Scott; Aslund, Melissa Whitfield] Intrinsik Environm Sci, Ottawa, ON, Canada. [DeLong, Tod R.] Avatar Environm, W Chester, PA USA. [Ferson, Scott] Appl Biomath, New York, NY USA. [Lortie, John P.] Stantec, Topsham, ME USA. [Ferson, Scott] Environm Canada, Chem Evaluat Branch, Gatineau, PQ, Canada. [MacDonald, Drew B.; McGrath, Richard] Sleeman Hanley & DiNitto, Boston, MA USA. [Pawlisz, Andrzej] Conestoga Rovers & Associates, Dallas, TX USA. [Svirsky, Susan C.] US EPA, New England Off, Boston, MA USA. [Thompson, Ryan P.] Idea Matrix Consulting, Ottawa, ON, Canada. RP Moore, DRJ (reprint author), Intrinsik Environm Sci, New Gloucester, ME 04260 USA. EM dmoore@intrinsikscience.com FU USEPA, Region 1 FX The wildlife risk assessment for the Housatonic River was the result of an extensive collaborative effort among staff at Applied Biomathematics; Avatar Environmental; Cadmus Group; EVS Environmental Consultants; Intrinsik Environmental Sciences (formerly Cantox Environmental); Sleeman, Hanley and DiNitto; USEPA; Weston Solutions; and Woodlot Alternatives. This assessment would not have been possible without their efforts. The wildlife assessment also benefited greatly from reviews by Valery Forbes, Tom LaPoint, James Oris, Mary Ann ranger, Brad Sample, Ralph Stahl and Tim Thompson. We would also like to thank the various stakeholders that commented on the wildlife risk assessment, including staff and consultants from the Connecticut Department of Environmental Protection, General Electric and its consultants, Housatonic River Restoration, Massachusetts Audubon Society, Massachusetts Department of Environmental Protection, National Oceanic and Atmospheric Administration, US Fish and Wildlife Service, and others. Funding was provided by USEPA, Region 1. NR 52 TC 0 Z9 0 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 174 EP 184 DI 10.1002/ieam.1661 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100015 PM 25976918 ER PT J AU Obrycki, JF Basta, NT Scheckel, K Stevens, BN Minca, KK AF Obrycki, John F. Basta, Nicholas T. Scheckel, Kirk Stevens, Brooke N. Minca, Kristen K. TI Phosphorus Amendment Efficacy for In Situ Remediation of Soil Lead Depends on the Bioaccessible Method SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID CONTAMINATED SOILS; RELATIVE BIOAVAILABILITY; CHEMICAL IMMOBILIZATION; ORAL BIOAVAILABILITY; VITRO; PB; EXTRACTION; PHOSPHATE; CADMIUM; ACID AB A validated method is needed to measure reductions of in vitro bioaccessible (IVBA) Pb in urban soil remediated with amendments. This study evaluated the effect of in vitro extraction solution pH and glycine buffer on bioaccessible Pb in P-treated soils. Two Pb-contaminated soils (790-1300 mg Pb kg-1), one from a garden and one from a city lot in Cleveland, OH, were incubated in a bench scale experiment for 1 yr. Six phosphate amendments, including bone meal, fish bone, poultry litter, monoammonium phosphate, diammonium phosphate, and triple superphosphate, were added to containers at two application rates. Lead IVBA was assessed using USEPA Method 1340 and three modified versions of this method. Modifications included using solutions with pH 1.5 and 2.5 as well as using solutions with and without 0.4 mol L-1 glycine. Soil amendments were ineffective in reducing IVBA Pb in these soils as measured by pH 1.5 with glycine buffer. The greatest reductions in IVBA Pb, from 5 to 26%, were found using pH 2.5 extractions. Lead mineral results showed several soil amendments promoted Pb phosphate formation, an indicator of remediation success. A significant negative linear relationship between reduction in IVBA Pb and Pb-phosphate formation was found only for pH 2.5 without glycine extraction solution. A modified USEPA Method 1340 without glycine and using pH 2.5 has the potential to predict P soil treatment efficacy and reductions in bioavailable Pb. C1 [Obrycki, John F.; Basta, Nicholas T.; Stevens, Brooke N.; Minca, Kristen K.] Ohio State Univ, Sch Environm & Nat Resources, Columbus, OH 43210 USA. [Scheckel, Kirk] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA. RP Basta, NT (reprint author), Ohio State Univ, Sch Environm & Nat Resources, 210 Kottman Hall,2021 Coffey Rd, Columbus, OH 43210 USA. EM basta.4@osu.edu OI Scheckel, Kirk/0000-0001-9326-9241 NR 35 TC 3 Z9 3 U1 4 U2 9 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD JAN-FEB PY 2016 VL 45 IS 1 BP 37 EP 44 DI 10.2134/jeq2015.05.0244 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA6XI UT WOS:000367948600006 PM 26828158 ER PT J AU Wu, YX Cox, SS Xu, Y Liang, YR Won, DY Liu, XY Clausen, PA Rosell, L Benning, JL Zhang, YP Little, JC AF Wu, Yaoxing Cox, Steven S. Xu, Ying Liang, Yirui Won, Doyun Liu, Xiaoyu Clausen, Per A. Rosell, Lars Benning, Jennifer L. Zhang, Yinping Little, John C. TI A reference method for measuring emissions of SVOCs in small chambers SO BUILDING AND ENVIRONMENT LA English DT Article DE Semi-volatile organic compounds; DEHP; Phthalates; Inter-laboratory study; Reference method ID ORGANIC-COMPOUNDS; PHTHALATE PLASTICIZER; EXPOSURE; INDOOR; FLEC; AIR AB Semi-volatile organic compounds (SVOCs) are indoor air pollutants that may have significant adverse effects on human health. Although emissions of volatile chemicals from building materials and consumer products are usually characterized in small chambers, few chamber studies have been conducted for SVOCs due to the challenges associated with analysis and the lack of validation procedures. There is an urgent need for a reliable and accurate chamber test method to verify these measurements. A reference method employing a specially-designed chamber has been developed and is undergoing extensive evaluation. A pilot inter-laboratory study (ILS) has been conducted with six laboratories performing chamber tests under identical conditions for di-2-ethylhexyl phthalate (DEHP). Results from this study showed inter-laboratory variations of 24% for DEHP emission rates, with closer agreement observed among intra-laboratory measurements for most of the participating laboratories. A mechanistic emission model fits well to the measured concentration profiles, demonstrating the feasibility of the proposed reference method to independently assess laboratory performance and validate SVOC emission tests. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wu, Yaoxing; Cox, Steven S.; Little, John C.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Xu, Ying; Liang, Yirui] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA. [Won, Doyun] Natl Res Council Canada, Ottawa, ON K1A 0R6, Canada. [Liu, Xiaoyu] US EPA, Res Triangle Pk, NC 27711 USA. [Clausen, Per A.] Natl Res Ctr Working Environm, Copenhagen, Denmark. [Rosell, Lars] SP Swedish Natl Testing & Res Inst, SE-50115 Boras, Sweden. [Benning, Jennifer L.] South Dakota Sch Mines & Technol, Dept Civil & Environm Engn, Rapid City, SD 57701 USA. [Zhang, Yinping] Tsinghua Univ, Dept Bldg Sci, Beijing 100084, Peoples R China. RP Little, JC (reprint author), Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. EM jcl@vt.edu RI Zhang, Yinping/B-5187-2012; Liang, Yirui/S-8303-2016; OI Liang, Yirui/0000-0002-8801-7266; Clausen, Per Axel/0000-0003-0217-6563 FU United States National Science Foundation [CBET 1066802, CBET 1335722] FX Financial support to Virginia Tech was provided by the United States National Science Foundation (CBET 1066802 and CBET 1335722). NR 28 TC 9 Z9 9 U1 12 U2 32 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-1323 EI 1873-684X J9 BUILD ENVIRON JI Build. Environ. PD JAN PY 2016 VL 95 BP 126 EP 132 DI 10.1016/j.buildenv.2015.08.025 PG 7 WC Construction & Building Technology; Engineering, Environmental; Engineering, Civil SC Construction & Building Technology; Engineering GA DA3LS UT WOS:000367699800012 ER PT J AU Phillips, MB Leonard, JA Grulke, CM Chang, DT Edwards, SW Brooks, R Goldsmith, MR El-Masri, H Tan, YM AF Phillips, Martin B. Leonard, Jeremy A. Grulke, Christopher M. Chang, Daniel T. Edwards, Stephen W. Brooks, Raina Goldsmith, Michael-Rock El-Masri, Hisham Tan, Yu-Mei TI A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID OCCUPATIONAL-EXPOSURE; DRUG DISCOVERY; TOXICITY; INHIBITION; TOXICOLOGY; ACETYLCHOLINESTERASE; ECOTOXICOLOGY; APPLICABILITY; CHLORPYRIFOS; PENTAMIDINE AB BACKGROUND: Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals. OBJECTIVES: We developed a conceptual workflow to examine exposure and ADME properties in relation to an MIE. The utility of this workflow was evaluated using a previously established AOP, acetylcholinesterase (AChE) inhibition. METHODS: Thirty chemicals found to inhibit human AChE in the ToxCast (TM) assay were examined with respect to their exposure, absorption potential, and ability to cross the blood-brain barrier (BBB). Structures of active chemicals were compared against structures of 1,029 inactive chemicals to detect possible parent compounds that might have active metabolites. RESULTS: Application of the workflow screened 10 "low-priority" chemicals of 30 active chemicals. Fifty-two of the 1,029 inactive chemicals exhibited a similarity threshold of >= 75% with their nearest active neighbors. Of these 52 compounds, 30 were excluded due to poor absorption or distribution. The remaining 22 compounds may inhibit AChE in vivo either directly or as a result of metabolic activation. CONCLUSIONS: The incorporation of exposure and ADME properties into the conceptual workflow eliminated 10 "low-priority" chemicals that may otherwise have undergone additional, resource-consuming analyses. Our workflow also increased confidence in interpretation of in vitro results by identifying possible "false negatives." C1 [Phillips, Martin B.; Leonard, Jeremy A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Grulke, Christopher M.] Lockheed Martin, Res Triangle Pk, NC USA. [Chang, Daniel T.; Goldsmith, Michael-Rock] Chem Comp Grp Inc, Montreal, PQ, Canada. [Edwards, Stephen W.; El-Masri, Hisham] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Brooks, Raina] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA. [Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Tan, YM (reprint author), 109 TW Alexander Dr,Mail Code E205-01, Res Triangle Pk, NC 27709 USA. EM tan.cecilia@epa.gov FU Oak Ridge Institute for Science and Education Research Participation Program at the U.S. EPA FX M.B.P. and J.A.L. were funded through the Oak Ridge Institute for Science and Education Research Participation Program at the U.S. EPA. NR 80 TC 5 Z9 5 U1 3 U2 28 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2016 VL 124 IS 1 BP 53 EP 60 DI 10.1289/ehp.1409450 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1XQ UT WOS:000367589600015 PM 25978103 ER PT J AU Etzel, RA Howard, SN AF Etzel, Ruth A. Howard, Sandra N. TI Renewing the Federal Commitment to Advance Children's Health: The President's Task Force on Environmental Health Risks and Safety Risks to Children SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Editorial Material C1 [Etzel, Ruth A.] US EPA, Washington, DC 20460 USA. [Howard, Sandra N.] US Dept HHS, Washington, DC 20201 USA. RP Etzel, RA (reprint author), US EPA, Washington, DC 20460 USA. EM etzel.ruth@epa.gov NR 6 TC 0 Z9 0 U1 0 U2 3 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2016 VL 124 IS 1 BP A3 EP A4 DI 10.1289/ehp.1511016 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1XQ UT WOS:000367589600002 PM 26720094 ER PT J AU Oczkowski, A Wigand, C Hanson, A Markham, E Miller, KM Johnson, R AF Oczkowski, Autumn Wigand, Cathleen Hanson, Alana Markham, Erin Miller, Kenneth M. Johnson, Roxanne TI Nitrogen Retention in Salt Marsh Systems Across Nutrient-Enrichment, Elevation, and Precipitation Regimes: a Multiple-Stressor Experiment SO ESTUARIES AND COASTS LA English DT Article DE Salt marsh; Tracer; Spartina alterniflora; Climate change; Precipitation; Stable nitrogen isotope; Experiment ID SEA-LEVEL RISE; MACROALGAL BLOOMS; TIDAL MARSH; IMPACTS; ISLAND; EUTROPHICATION; COMMUNITIES; VEGETATION; ABUNDANCE; RESPONSES AB In the Northeastern USA, multiple anthropogenic stressors, including changing nutrient loads, accelerated sea level rise, and altered climatic patterns, are co-occurring and are likely to influence salt marsh nitrogen (N) dynamics. We conducted a multiple-stressor mesocosm experiment to assess impacts of climate change and nutrient load on N uptake by the ecosystem dominant species. The New England salt marsh plant Spartina alterniflora was planted at mean high water (MHW) and 15 cm above and below MHW in tanks plumbed to mimic tides. The experiment consisted of two nutrient treatments (enriched, unenriched), three precipitation treatments (rain, storm, and no precipitation or control), and three elevations (low, mean, and high), with four replicate pots for each. A quarter of the way into the experiment (1 month), an N stable isotope tracer was added to a portion of the precipitation events received by the rain and storm treatments to assess how N is retained by the different components of each treatment. At the completion of the experiment, Spartina pots in the rain treatments retained far more tracer than the pots receiving the twice monthly storms, with the most tracer recovered at the highest elevation in all precipitation treatments as these pots received direct tracer input to stems and sediment surface. Experimental results suggest that the elevation of the marsh as well as the timing and delivery of rainfall may be important factors in how salt marshes intercept, retain, and transform N. C1 [Oczkowski, Autumn; Wigand, Cathleen; Hanson, Alana; Markham, Erin; Johnson, Roxanne] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Miller, Kenneth M.] CSC, Alexandria, VA 22310 USA. RP Oczkowski, A (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM oczkowski.autumn@epa.gov FU US Environmental Protection Agency FX We thank Earl Davey, Beth Watson, Joe Bishop, Gabrielle Sousa, Kirk Silver, Kevin Kelly, John Sardelli, Russ Ahlgren, Kristen Jones, Glen Thursby, and Chitanya Gopu for assistance with experiments. We also thank Patricia DeCastro for help creating Fig. 1. John Kiddon, Elizabeth Watson, and Rick McKinney provided helpful input on an earlier version of the manuscript. This report is contribution number ORD-008008 of the US EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division. Although the information in this document has been funded by the US Environmental Protection Agency, it does not necessarily reflect the views of the agency and no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 45 TC 1 Z9 1 U1 5 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD JAN PY 2016 VL 39 IS 1 BP 68 EP 81 DI 10.1007/s12237-015-9975-x PG 14 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DA0ZK UT WOS:000367525900006 ER PT J AU Strand, T Gullett, B Urbanski, S O'Neill, S Potter, B Aurell, J Holder, A Larkin, N Moore, M Rorig, M AF Strand, Tara Gullett, Brian Urbanski, Shawn O'Neill, Susan Potter, Brian Aurell, Johanna Holder, Amara Larkin, Narasimhan Moore, Mark Rorig, Miriam TI Grassland and forest understorey biomass emissions from prescribed fires in the southeastern United States - RxCADRE 2012 SO INTERNATIONAL JOURNAL OF WILDLAND FIRE LA English DT Article DE black carbon; combustion efficiency; emissions factor; particulate matter; smoke ID TRANSFORM INFRARED-SPECTROSCOPY; BLACK CARBON MEASUREMENTS; TRACE GAS EMISSIONS; LABORATORY MEASUREMENTS; AEROSOLS; SMOKE; ABSORPTION; US; PARTICLES; AIRBORNE AB Smoke measurements were made during grass and forest understorey prescribed fires as part of a comprehensive programme to understand fire and smoke behaviour. Instruments deployed on the ground, airplane and tethered aerostat platforms characterised the smoke plumes through measurements of carbon dioxide (CO2), carbon monoxide (CO), methane (CH4) and particulate matter (PM), and measurements of optical properties. Distinctions were observed in aerial and ground-based measurements, with aerial measurements exhibiting smaller particle size distributions and PM emission factors, likely due to particle settling. Black carbon emission factors were similar for both burns and were highest during the initial flaming phase. On average, the particles from the forest fire were less light absorbing than those from the grass fires due to the longer duration of smouldering combustion in the forest biomass. CO and CH4 emission factors were over twice as high for the forest burn than for the grass burn, corresponding with a lower modified combustion efficiency and greater smouldering combustion. This dataset reveals the evolution of smoke emissions from two different commonly burned fuel types and demonstrates the complexity of emission factors. C1 [Strand, Tara] Scion, Crown Forest Res Inst, Christchurch 8041, New Zealand. [Gullett, Brian; Holder, Amara] US EPA, Off Res & Dev, Durham, NC 27711 USA. [Urbanski, Shawn] USDA Forest Serv, Rocky Mt Res Stn, Missoula, MT 59808 USA. [O'Neill, Susan; Potter, Brian; Larkin, Narasimhan; Moore, Mark; Rorig, Miriam] USDA Forest Serv, Pacific NW Res Stn, Seattle, WA 98103 USA. [Aurell, Johanna] US EPA, Natl Res Council, Off Res & Dev, Natl Risk Management Res Lab, Durham, NC 27711 USA. RP Strand, T (reprint author), Scion, Crown Forest Res Inst, Forestry Bldg,Forestry Rd, Christchurch 8041, New Zealand. EM tara.strand@scionresearch.com FU Joint Fire Science Program [11-2-1-11]; Strategic Environmental Research and Development Program; US EPA Office of Research and Development; National Research Council FX This work was funded by the Joint Fire Science Program (Project #11-2-1-11), the Strategic Environmental Research and Development Program (Dr John Hall) and the US EPA Office of Research and Development. This research was performed while Johanna Aurell held a National Research Council Research Associateship Award at the US EPA/NRMRL. We would like to thank Dave Hubble, our mission Cessna 337 pilot, and Aaron Knobloch of USFS Southern Region for his support in facilitating the air-plane arrangements. Contributing EPA personnel included Chris Pressley, Bill Squier, Bill Mitchell, Michael Hays and Robert Black (Oak Ridge Institute for Science and Education postdoctoral fellow). Aerostat operations were handled by Rob Gribble (ISSI Inc.). Jeff Blair of AethLabs donated use of the AE-52. We also thank Candace Krull for her assistance with preparing field equipment before the study and Gary Curcio for contributing instrumentation, expertise and aid in deploying the equipment. We also give a special thanks to Scott Pokswinski (aka Daisycutter) who watched out for us while at the field site. The use of trade or firm names in this publication is for reader information and does not imply endorsement by the US Department of Agriculture and Environmental Protection Agency of any product or service. NR 46 TC 4 Z9 4 U1 9 U2 35 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1049-8001 EI 1448-5516 J9 INT J WILDLAND FIRE JI Int. J. Wildland Fire PY 2016 VL 25 IS 1 BP 102 EP 113 DI 10.1071/WF14166 PG 12 WC Forestry SC Forestry GA DA3VH UT WOS:000367727100009 ER PT J AU Serre, S Mickelsen, L Calfee, MW Wood, JP Gray, MS Scheffrahn, RH Perez, R Kern, WH Daniell, N AF Serre, S. Mickelsen, L. Calfee, M. W. Wood, J. P. Gray, M. S., Jr. Scheffrahn, R. H. Perez, R. Kern, W. H., Jr. Daniell, N. TI Whole-building decontamination of Bacillus anthracis Sterne spores by methyl bromide fumigation SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE antibacterial; commercial fumigation; non-corrosive; sensitive materials; sporicide ID MAIL FACILITY; DIOXIDE; ATTACKS AB Aims: To evaluate the field inactivation of Bacillus anthracis Sterne spores with methyl bromide (MB) using commercial fumigation techniques. Methods and Results: Eighty-seven wood and 87 glass coupons each containing ca. 1 x 10(6) B. anthracis Sterne spores, were placed in 22 locations inside a 1444 m(3) conference building. Four additional 12-coupon sets (six wood, six glass) were removed from the building at 16, 24, 32 and 40 h during fumigation. The building was sealed under two tarpaulins and fumigated with MB at >= 225 g m(-3) mean concentration for 48 h at 28 degrees C and 83% RH. All B. anthracis spores fumigated for more than 16 h were inactivated. A single wood coupon from the 16-h set yielded ca. 2 x 10(3) CFU. No damage to the building or its contents was observed. Conclusions: MB fumigation is a rapid, economical and effective whole-structure decontamination method for B. anthracis spores. Significance and Impact of the Study: MB fumigation offers a method of whole-structure B. anthracis decontamination without removal of materials, damage to sensitive electronics, costly indoor retrofitting. C1 [Serre, S.; Mickelsen, L.; Calfee, M. W.; Wood, J. P.; Gray, M. S., Jr.] United States Environm Protect Agcy, Res Triangle Pk, NC USA. [Scheffrahn, R. H.; Perez, R.; Kern, W. H., Jr.] Univ Florida, Ft Lauderdale Res & Educ Ctr, Davie, FL 33314 USA. [Daniell, N.] Environm Serv, CSS Dynamac Corp, Atlanta, GA USA. RP Scheffrahn, RH (reprint author), Univ Florida, Ft Lauderdale Res & Educ Ctr, 3205 Coll Ave, Davie, FL 33314 USA. EM rhsc@ufl.edu OI Wood, Joseph/0000-0001-6316-9418; Calfee, Michael/0000-0001-6544-329X FU Unites States Environmental Protection Agency [GMO2413]; Dynamac Corporation (Fairfax, VA) [GMO747] FX The Unites States Environmental Protection Agency was the prime project funding agency under grant GMO2413. Dynamac Corporation (Fairfax, VA) was the contracting sponsor under grant GMO747. NR 26 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD JAN PY 2016 VL 120 IS 1 BP 80 EP 89 DI 10.1111/jam.12974 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA DA3HD UT WOS:000367686900008 PM 26492200 ER PT J AU Riitters, K Wickham, J Costanza, JK Vogt, P AF Riitters, Kurt Wickham, James Costanza, Jennifer K. Vogt, Peter TI A global evaluation of forest interior area dynamics using tree cover data from 2000 to 2012 SO LANDSCAPE ECOLOGY LA English DT Article DE Spatial analysis; Forest fragmentation; Monitoring; Assessment ID HABITAT FRAGMENTATION; UNITED-STATES; ECOLOGICAL THRESHOLDS; MULTIPLE SCALES; TEMPORAL-CHANGE; LANDSCAPES; EDGES; BIODIVERSITY; COMMUNITIES; MANAGEMENT AB Published maps of global tree cover derived from Landsat data have indicated substantial changes in forest area from 2000 to 2012. The changes can be arranged in different patterns, with different consequences for forest fragmentation. Thus, the changes in forest area do not necessarily equate to changes in forest sustainability. The objective is to assess global and regional changes in forest fragmentation in relation to the change of forest area from 2000 to 2012. Using published global tree cover data, forest and forest interior areas were mapped in 2000 and 2012. The locations of forest interior change were compared to the locations of overall forest change to identify the direct (pixel level) and indirect (landscape level) components of forest interior change. The changes of forest interior area were compared to the changes of total forest area in each of 768 ecological regions. A 1.71 million km(2) (3.2 %) net loss of global forest area translated to a net loss of 3.76 million km(2) (9.9 %) of forest interior area. The difference in loss rates was consistent in most of the 768 ecological regions. The indirect component accounted for 2.44 million km(2) of the net forest interior change, compared to 1.32 million km(2) that was attributable to the direct component. Forest area loss alone from 2000 to 2012 underestimates ecological risks from forest fragmentation. In addition to the direct loss of forest, there was a widespread shift of the remaining global forest to a more fragmented condition. C1 [Riitters, Kurt] USDA, Southern Res Stn, Forest Serv, Res Triangle Pk, NC 27709 USA. [Wickham, James] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Costanza, Jennifer K.] N Carolina State Univ, North Carolina Cooperat Fish & Wildlife Res Unit, Dept Appl Ecol, Raleigh, NC 27695 USA. [Vogt, Peter] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, Italy. RP Riitters, K (reprint author), USDA, Southern Res Stn, Forest Serv, 3041 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM kriitters@fs.fed.us OI Costanza, Jennifer/0000-0002-3747-538X FU United States Environmental Protection Agency (EPA), through its Office of Research and Development FX We thank M. Hansen, his colleagues, and Google Earth Engine for the global forest change maps. The United States Environmental Protection Agency (EPA), through its Office of Research and Development, partially funded and collaborated in the research described here. It has been subjected to EPA review and approved for publication. NR 56 TC 6 Z9 6 U1 12 U2 31 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 EI 1572-9761 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD JAN PY 2016 VL 31 IS 1 BP 137 EP 148 DI 10.1007/s10980-015-0270-9 PG 12 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DA2AR UT WOS:000367598200011 ER PT J AU Sexton, JE Desmonds, T Quick, K Taylor, R Abramowitz, J Forge, A Kros, CJ Birnbaumer, L Wood, JN AF Sexton, Jane E. Desmonds, Terri Quick, Kathryn Taylor, Ruth Abramowitz, Joel Forge, Andy Kros, Corne J. Birnbaumer, Lutz Wood, John N. TI The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing SO NEUROSCIENCE LETTERS LA English DT Article DE Mechanosensation; TRP channels; Touch ID DORSAL-ROOT GANGLION; HAIR-CELLS; MECHANICAL HYPERALGESIA; TRPA1 CONTRIBUTES; CHANNELS; TRANSDUCER; PIEZO2; MICE; SENSATION; CURRENTS AB Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electro-physiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Sexton, Jane E.; Quick, Kathryn; Wood, John N.] UCL, Mol Nocicept Grp, Wolfson Inst Biomed Res, London WC1E 6BT, England. [Desmonds, Terri; Kros, Corne J.] Univ Sussex, Sch Life Sci, Sussex Neurosci, Brighton BN1 9QG, E Sussex, England. [Taylor, Ruth; Forge, Andy] UCL Ear Inst, London WC1X 8EE, England. [Abramowitz, Joel; Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Neurobiol Lab, Res Triangle Pk, NC 27709 USA. [Kros, Corne J.] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands. RP Sexton, JE (reprint author), UCL, Mol Nocicept Grp, Wolfson Inst Biomed Res, London WC1E 6BT, England. EM jane.sexton.09@ucl.ac.uk RI Abramowitz, Joel/A-2620-2015 FU NIH Intramural Research Program of the NIH [75%). High probability of impact (>50%) occurred in the river at low flows and all flows in the creek with treated mixed/flowback water discharge. Modeled reduction in the effluent discharge rate reduced downstream impacts proportionally. Transient simulation showed that transient peak concentrations may exceed time-averaged concentration by up to a factor of four when mixing conditions are met. C1 [Weaver, James W.; Xu, Jie; Mravik, Susan C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74820 USA. RP Weaver, JW (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA. EM weaver.jim@epa.gov; xu.jie@epa.gov; mravik.susan@epa.gov FU U.S. EPA FX The authors wish to thank Angela McFadden, Amy Bergdale, and Chad Harsh of U.S. EPA for facilitating access to NPDES permit data. The authors acknowledge valuable input from Richard Lowrance, Stephen Kraemer, and Stig Regli, U.S. EPA; Kay Pinley, U.S. EPA grantee; Ashley McElmurry, contractor to U.S. EPA, WASP simulation results from Chris Knightes, U.S. EPA and Bob Ambrose. Clinton Hittle of USGS supplied unpublished USGS flow-discharge data for mixing zone estimation. The authors thank several internal EPA reviewers and three anonymous journal reviewers for their comments, which improved the quality of the paper. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 57 TC 4 Z9 4 U1 8 U2 30 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD JAN PY 2016 VL 142 IS 1 AR 04015050 DI 10.1061/(ASCE)EE.1943-7870.0000968 PG 14 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CY8HY UT WOS:000366650600001 ER PT J AU Zhao, L Wang, B Armenante, PM Conmy, R Boufadel, MC AF Zhao, Lin Wang, Bing Armenante, Piero M. Conmy, Robyn Boufadel, Michel C. TI Characterization of Turbulent Properties in the EPA Baffled Flask for Dispersion Effectiveness Testing SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Article DE Oil spills; Baffled flask; Mixing energy; Turbulence structure; Particle image velocimetry; Data collection ID DISSIPATION RATE ESTIMATION; ENERGY-DISSIPATION; PIV; FLOW; TURBINE; CHANNEL; TANK AB The baffled flask test (BFT) has been proposed by United States Environmental Protection Agency to be adopted as the official standard protocol for testing dispersant effectiveness. The mixing energy in the baffled flask is investigated in this paper. Particle image velocimetry (PIV) was used to measure the water velocity in the flask placed at an orbital shaker that was rotated at seven rotation speeds: 100, 125, 150, 160, 170, 200, and 250 rpm. Two dimensional velocity fields in large and small vertical cross sections of the flask for each rotation speed were obtained. The one-dimensional (1D) energy spectra indicates the existence of inertial subrange. The estimated average energy dissipation rates were in the range 7.65 x 10(-3) to 4 W/kg for rotation speeds of Omega = 100-250 rpm, of which it is larger than the one estimated by prior studies using single-point velocity measurement techniques for Omega = 100 and 200 rpm. Factors such as instruments used, velocity components measured, and different analysis methods could contribute to the discrepancies in the results. The Kolmogorov scale estimated in this study for all seven rotation speeds approached the size of oil droplets observed at sea, which is 50-400 mu m. The average energy dissipation rate, epsilon and Kolmogorov microscale, eta, in the flasks were correlated to the rotation speed, and it was found that (epsilon) over bar = 9.0 x 10(-5) Exp(0.043 Omega) with R-2 = 0.97 and (eta) over bar = 1,463 Exp(-0.015 Omega) with R-2 = 0.98. (C) 2015 American Society of Civil Engineers. C1 [Zhao, Lin; Boufadel, Michel C.] New Jersey Inst Technol, Ctr Nat Resources Dev & Protect, Dept Civil & Environm Engn, Newark, NJ 07102 USA. [Wang, Bing] New Jersey Inst Technol, Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA. [Armenante, Piero M.] New Jersey Inst Technol, Grad Program Pharmaceut Engn, Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA. [Conmy, Robyn] US EPA, Natl Risk Management Lab, Cincinnati, OH 45269 USA. RP Boufadel, MC (reprint author), New Jersey Inst Technol, Ctr Nat Resources Dev & Protect, Dept Civil & Environm Engn, 323 MLK Blvd, Newark, NJ 07102 USA. EM boufadel@gmail.com OI Zhao, Lin/0000-0003-1959-4120 FU United States Environmental Protection Agency [EP-C-11-006] FX This work was supported in part by funding from the United States Environmental Protection Agency under contract EP-C-11-006. However, it does not represent the views of the agency and no official endorsement should be implied. NR 32 TC 3 Z9 3 U1 2 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD JAN PY 2016 VL 142 IS 1 AR 04015044 DI 10.1061/(ASCE)EE.1943-7870.0001000 PG 14 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CY8HY UT WOS:000366650600005 ER PT J AU Barkdoll, BD Murray, K Sherrin, A O'Neill, J Ghimire, SR AF Barkdoll, Brian D. Murray, Keenan Sherrin, Alicia O'Neill, Jennifer Ghimire, Santosh R. TI Effective-Power-Ranking Algorithm for Energy and Greenhouse Gas Reduction in Water Distribution Systems through Pipe Enhancement SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Eco-efficiency analysis; Global warming potential; Infrastructure; Life-cycle costs; Low-impact management; Sensitivity analysis; Water-energy nexus ID DISTRIBUTION NETWORKS; SENSITIVITY-ANALYSIS; DESIGN; COST; OPTIMIZATION; EMISSIONS; INDEX AB Many global municipal water distribution systems (WDS) are in need of repair. To save energy and greenhouse gas emissions due to pumping, pipes that need to be replaced can be enhanced by being enlarged and made of a smoother material. To choose which pipes to thus enhance first given a limited budget, an algorithm is introduced based on enhancing the pipe that requires the most effective power, which is defined as the product of discharge, specific weight, and headloss. The algorithm was verified with complete enumeration, life- cycle, and environmental- impact modeling on seven realistic WDSs. It was found that the additional cost and greenhouse gasses (GHG) emitted from purchasing and manufacturing a larger pipe are quickly recovered by the reduced cost and GHG emissions due to less pumping being required. The proposed pipe enhancement should be verified with modeling, however, since increased payback periods for both costs and GHG emissions can result if an increase in pipe size causes water to travel a longer path. (C) 2015 American Society of Civil Engineers. C1 [Barkdoll, Brian D.; Murray, Keenan; Sherrin, Alicia; O'Neill, Jennifer] Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. [Ghimire, Santosh R.] US EPA, Athens, GA 30605 USA. RP Barkdoll, BD (reprint author), Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. EM barkdoll@mtu.edu; kmurray@mtu.edu; arsherri@mtu.edu; jaoneill@mtu.edu; ghimire.santosh@epa.gov NR 35 TC 0 Z9 0 U1 1 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PLAN MAN JI J. Water Resour. Plan. Manage.-ASCE PD JAN PY 2016 VL 142 IS 1 AR 06015001 DI 10.1061/(ASCE)WR.1943-5452.0000568 PG 5 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CY9TW UT WOS:000366750200012 ER PT J AU Gordon, CJ Phillips, PM Johnstone, AFM AF Gordon, C. J. Phillips, P. M. Johnstone, A. F. M. TI Impact of genetic strain on body fat loss, food consumption, metabolism, ventilation, and motor activity in free running female rats SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Exercise; Genetic strain; Body composition; Metabolism; Running wheel; Food consumption ID BROWN-NORWAY RATS; ESTROUS-CYCLE; SEX-DIFFERENCES; OLETF RATS; WHEEL; EXERCISE; TEMPERATURE; AGE; INTENSITY; ANXIETY AB Chronic exercise is considered as one of the most effective means of countering symptoms of the metabolic syndrome (MS) such as obesity and hyperglycemia. Rodent models of forced or voluntary exercise are often used to study the mechanisms of MS and type 2 diabetes. However, there is little known on the impact of genetic strain on the metabolic response to exercise. We studied the effects of housing rats with running wheels (RW) for 65 days-compared to sedentary (SED) housing in five female rat strains: Sprague-Dawley (SD), Long-Evans (LE), Wistar (WIS), spontaneously hypertensive (SHR), and Wistar-Kyoto (WKY). Key parameters measured were total distance run, body composition, food consumption, motor activity, ventilatory responses by plethysmography, and resting metabolic rate (MR). WKY and SHR ran significantly more than the WIS, LE, and SD strains. Running-induced reduction in body fat was affected by strain but not by distance run. LE's lost 6% fat after 21 d of running whereas WKY's lost 2% fat but ran 40% more than LE's. LE and WIS lost body weight while the SHR and WKY strains gained weight during running. Food intake with RW was markedly increased in SHR, WIS, and WKY while LE and SD showed modest increases. Exploratory motor activity was reduced sharply by RW in all but the SD strain. Ventilatory parameters were primarily altered by RW in the SHR, WKY, and WIS strains. MR was unaffected by RW. In an overall ranking of physiological and behavioral responses to RW, the SD strain Was considered the least responsive whereas the WIS was scored as most responsive. In terms of RW-induced fat loss, the LE strain appears to be the most ideal. These results should be useful in the future selection of rat models to study benefits of volitional exercise. Published by Elsevier Inc. C1 [Gordon, C. J.; Phillips, P. M.; Johnstone, A. F. M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. RP Gordon, CJ (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Gordon.christopher@epa.gov NR 25 TC 4 Z9 4 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JAN 1 PY 2016 VL 153 BP 56 EP 63 DI 10.1016/j.physbeh.2015.10.025 PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA CZ0AP UT WOS:000366767800008 PM 26597120 ER PT J AU Morgan, MK Sobus, JR Barr, DB Croghan, CW Chen, FL Walker, R Alston, L Andersen, E Clifton, MS AF Morgan, Marsha K. Sobus, Jon R. Barr, Dana Boyd Croghan, Carry W. Chen, Fu-Lin Walker, Richard Alston, Lillian Andersen, Erik Clifton, Matthew S. TI Temporal variability of pyrethroid metabolite levels in bedtime, morning, and 24-h urine samples for 50 adults in North Carolina SO ENVIRONMENTAL RESEARCH LA English DT Article DE Pyrethroids; Adults; Urine; Homes; Biomonitoring; Variability ID DAY-CARE-CENTERS; PREGNANT-WOMEN; MASS-SPECTROMETRY; NATIONAL-HEALTH; US POPULATION; EXPOSURE; PESTICIDES; INSECTICIDES; ORGANOPHOSPHATE; BIOMARKERS AB Pyrethroid insecticides are widely used to control insects in both agricultural and residential settings worldwide. Few data are available on the temporal variability of pyrethroid metabolites in the urine of non-occupationally exposed adults. In this work, we describe the study design and sampling methodology for the Pilot Study to Estimate Human Exposures to Pyrethroids using an Exposure Reconstruction Approach (Ex-R study). Two major objectives were to quantify the concentrations of several pyrethroid metabolites in bedtime, first morning void (FMV), and 24-h urine samples as concentration (wet weight), specific-gravity (SG) corrected, creatinine (CR) corrected, and excretion rate values for 50 Ex-R adults over a six-week monitoring period and to determine if these correction approaches for urine dilution reduced the variability of the biomarker levels. The Ex-R study was conducted at the United States Environmental Protection Agency's Human Studies Facility in Chapel Hill, North Carolina USA and at participants' homes within a 40-mile radius of this facility. Recruitment of participants and field activities occurred between October 2009 and May 2011. Participants, ages 19-50 years old, provided daily food, activity, and pesticide-use diaries and collected their own urine samples (bedtime, FMV, and 24-h) during weeks 1, 2, and 6 of a six-week monitoring period. A total of 2503 urine samples were collected from the study participants. These samples were analyzed for the pyrethroid metabolites 3-phenoxybenzoic acid (3-PBA), cis/trans-3-(2,2-dichloroviny1)-2,2-dimethyl-cyclopropane carboxylic acid (cis/trans-DCCA), and 2-methyl-3-phenylbenzoic acid (MPA) using high performance liquid chromatography/ tandem mass spectrometry. Only 3-PBA was frequently detected ( > 50%) in the adult urine samples. Median urinary 3-PBA levels were 0.88 ng/mL, 0.96 ng/mL-SG, 1.04 ng/mg, and 1.04 ng/min for concentration, SG-corrected, CR-corrected, and excretion rate values, respectively, across all urine samples. The results showed that median urinary 3-PBA concentrations were consistently the lowest in FMV samples (0.77 ng/mL, 0.68 ng/mL-SG, 0.68 ng/mg, and 0.58 ng/min) and the highest in 24-h samples (0.92 ng/mL, 1.06 ng/mL-SG, 1.18 ng/mg, and 119 ng/min) across all four methods. Intraclass correlation coefficient (ICC) estimates for 3-PBA indicated poor reproducibility ( < 0.22) for all urine sample types and methods over a day, week, and six weeks. Correcting for urine sample dilution, based on either SG, CR or urine output, introduced additional measurement variability both between- and within-individuals. These results indicate that a single measure of urinary 3-PBA was not sufficient to characterize average exposure regardless of sample type, correction method, and time frame of collection. In addition, the study results can be used to inform the design of exposure characterization strategies in relevant environmental epidemiology studies in the future. Published by Elsevier Inc. C1 [Morgan, Marsha K.; Sobus, Jon R.; Croghan, Carry W.; Chen, Fu-Lin; Walker, Richard; Alston, Lillian; Andersen, Erik; Clifton, Matthew S.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. RP Morgan, MK (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM morgan.marsha@epa.gov FU US EPA FX We sincerely thank the adult volunteers who participated in the Ex-R study. We also thank Ronald Williams, James Starr, Denise McMillian, Kent Thomas, and Daniel Stout II for their technical assistance during the study. We also gratefully acknowledge WE-STAT (Andrea Ware and Bethany Bradford) for their valuable assistance in recruiting study participants. This work was funded in whole by the US EPA. Disclaimer: "The US EPA through its Office of Research and Development has provided administrative review of this article and approved it for publication." NR 51 TC 3 Z9 3 U1 4 U2 17 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD JAN PY 2016 VL 144 BP 81 EP 91 DI 10.1016/j.envres.2015.11.003 PN A PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CY5HO UT WOS:000366438900009 PM 26584066 ER PT J AU Ro, KS Novak, JM Johnson, MG Szogi, AA Libra, JA Spokas, KA Bae, S AF Ro, K. S. Novak, J. M. Johnson, M. G. Szogi, A. A. Libra, J. A. Spokas, K. A. Bae, S. TI Leachate water quality of soils amended with different swine manure-based amendments SO CHEMOSPHERE LA English DT Article DE Hydrochar; Swine manure; Leachate water quality; Soil amendment; Soil fertility ID HYDROTHERMAL CARBONIZATION; TEMPERATURE PYROLYSIS; RENEWABLE ENERGY; POULTRY LITTER; BIOCHAR; HYDROCHAR; NITROGEN; IMPACT; CARBON; FATE AB In the face of the rising level of manure production from concentrated animal feeding operations (CAFOs), management options are being sought that can provide nutrient recycling for plant growth and improved soil conditions with minimal environmental impacts. Alternatives to direct manure application are composting and thermochemical conversion which can destroy pathogens and improve handling and storage. The effect of four forms of swine manure-based soil amendments (raw, compost, hydrochar, and pyrochar) on soil fertility and leachate water quality characteristics of a sandy soil were investigated in soil incubation experiments. All four amendments significantly increased soil carbon, cation exchange capacity and available nutrient contents of the soil. However, hydrochar amended soil leached lower amounts of N, P, and K compared to the other amendments including the control. On the other hand, pyrochar amended soil leached higher concentrations of P and K. Subsequent tests on the hydrochar for K and N adsorption isotherms and surface analysis via XPS suggested that these nutrients were not sorbed directly to the hydrochar surface. Although it is still not clear how these nutrients were retained in the soil amended with hydrochar, it suggests a great potential for hydrochar as an alternative manure management option as the hydrochar can be soil applied while minimizing potential environmental issues from the leaching of high nutrient concentrations to water bodies. Published by Elsevier Ltd. C1 [Ro, K. S.; Novak, J. M.; Szogi, A. A.] USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Johnson, M. G.] US EPA, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Libra, J. A.] Leibniz Inst Agr Engn, Potsdam, Germany. [Spokas, K. A.] USDA ARS, Soil & Water Management Res, St Paul, MN 55108 USA. [Bae, S.] Seoul Womens Univ, Seoul, South Korea. RP Ro, KS (reprint author), USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. RI Spokas, Kurt/F-4839-2016; Libra, Judy/K-3092-2013 OI Spokas, Kurt/0000-0002-5049-5959; Libra, Judy/0000-0001-9307-7776 FU U.S. Environmental Protection Agency [DW-12-92342301]; USDA-ARS National Program Agricultural and Industrial Byproduct Utilization [214] FX The authors would like to acknowledge the technical support provided by Mr. Melvin Johnson, Mr. Don Watt, and Mr. Paul Shumaker of the USDA-ARS Coastal Plains Soil, Water & Plant Research Center, Florence, SC, and Dr. Stephen Golledge at the University of Oregon Center for Advanced Material Characterization for his help collecting the XPS data. This research is part of the USDA-ARS National Program 214 Agricultural and Industrial Byproduct Utilization. Mention of trade names or commercial products is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture. In addition, the research described in this article has been funded in part by the U.S. Environmental Protection Agency through an Interagency Agreement (DW-12-92342301) to USDA Agricultural Research Service. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the EPA. NR 39 TC 3 Z9 3 U1 12 U2 59 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2016 VL 142 BP 92 EP 99 DI 10.1016/j.chemosphere.2015.05.023 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX0DZ UT WOS:000365368400014 PM 26025669 ER PT J AU Novak, J Sigua, G Watts, D Cantrell, K Shumaker, P Szogi, A Johnson, MG Spokas, K AF Novak, Jeff Sigua, Gilbert Watts, Don Cantrell, Keri Shumaker, Paul Szogi, Ariel Johnson, Mark G. Spokas, Kurt TI Biochars impact on water infiltration and water quality through a compacted subsoil layer SO CHEMOSPHERE LA English DT Article DE Biochars; Soil water infiltration; Ultisol; Water quality ID LOW-TEMPERATURE PYROLYSIS; HYDRAULIC-PROPERTIES; PHYSICAL-PROPERTIES; DEEP TILLAGE; SOILS; FEEDSTOCKS; POULTRY; PLAINS; SAND AB Soils in the SE USA Coastal Plain region frequently have a compacted subsoil layer (E horizon), which is a barrier for water infiltration. Four different biochars were evaluated to increase water infiltration through a compacted horizon from a Norfolk soil (fine-loamy, kaolinitic, thermic, Typic Kandiudult). In addition, we also evaluated biochars effect on water quality. Biochars were produced by pyrolysis at 500 degrees C from pine chips (Pinus taeda), poultry litter (Gallus domesticus) feedstocks, and as blends (50:50 and 80:20) of pine chip:poultry litter. Prior to pyrolysis, the feedstocks were pelletized and sieved to >2-mm pellets. Each biochar was mixed with the subsoil at 20 g/kg (w/w) and the mixture was placed in columns. The columns were leached four times with Milli-Q water over 128 d of incubation. Except for the biochar produced from poultry litter, all other applied biochars resulted in significant water infiltration increases (0.157-0.219 mL min(-1); p < 0.05) compared to the control (0.095 mL min(-1)). However, water infiltration in each treatment were influenced by additional water leaching. Leachates were enriched in PO4, SO4, Cl, Na, and K after addition of poultry litter biochar, however, their concentrations declined in pine chip blended biochar treatments and after multiple leaching. Adding biochars (except 100% poultry litter biochar) to a compacted subsoil layer can initially improve water infiltration, but, additional leaching revealed that the effect remained only for the 50:50 pine chip:poultry litter blended biochar while it declined in other biochar treatments. Published by Elsevier Ltd. C1 [Novak, Jeff; Sigua, Gilbert; Watts, Don; Cantrell, Keri; Shumaker, Paul; Szogi, Ariel] USDA ARS, Coastal Plain Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Johnson, Mark G.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. [Spokas, Kurt] USDA ARS, Soil & Water Management Res Unit, St Paul, MN 55108 USA. RP Novak, J (reprint author), USDA ARS, Coastal Plain Soil Water & Plant Res Ctr, 2611 West Lucas St, Florence, SC 29501 USA. EM jeff.novak@ars.usda.gov RI Spokas, Kurt/F-4839-2016 OI Spokas, Kurt/0000-0002-5049-5959 FU US Department of Agriculture-Agricultural Research Service [60-6657-1-2004]; U.S. Environmental Protection Agency (EPA) [DE-12-9232301-1] FX The information in this article has been funded through an Interagency Agreement between the US Department of Agriculture-Agricultural Research Service (60-6657-1-2004) and the U.S. Environmental Protection Agency (EPA; DE-12-9232301-1). It has been subjected to review by scientists of the USDA-ARS Coastal Plains Research Center and by the National health and Environment Effects Research Laboratory's Western Ecology Division and approved for journal submission. Approval does not signify that the contents reflects the views of the US EPA, nor does mention of trade names or commercial products constituent endorsement or recommendation for use. We thank Ms. Bree Williams, Cierra Buckmann, and Dr. D'jaafar Rehrah for laboratory support and Dr. Jack Horner and Ms. Tracey Pepper for microscopy and nano-imaging analyses. NR 54 TC 4 Z9 4 U1 4 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2016 VL 142 BP 160 EP 167 DI 10.1016/j.chemosphere.2015.06.038 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX0DZ UT WOS:000365368400023 PM 26138710 ER PT J AU Sigua, GC Novak, JM Watts, DW Johnson, MG Spokas, K AF Sigua, G. C. Novak, J. M. Watts, D. W. Johnson, M. G. Spokas, K. TI Efficacies of designer biochars in improving biomass and nutrient uptake of winter wheat grown in a hard setting subsoil layer SO CHEMOSPHERE LA English DT Article DE Designer biochars; Belowground biomass; Aboveground biomass; Hard setting subsoil ID COASTAL-PLAIN; SOIL AMENDMENTS; NORTH-CAROLINA; SALT-STRESS; GRAIN-YIELD; TEMPERATURE; CHARCOAL; CARBON; ROOT; DECOMPOSITION AB In the Coastal Plains region of the United States, the hard setting subsoil layer of Norfolk soils results in low water holding capacity and nutrient retention, which often limits root development. In this region, the Norfolk soils are under intensive crop production that further depletes nutrients and reduces organic carbon (C). Incorporation of pyrolyzed organic residues or "biochars" can provide an alternative recalcitrant C source. However, biochar quality and effect can be inconsistent and different biochars react differently in soils. We hypothesized that addition of different designer biochars will have variable effects on biomass and nutrient uptake of winter wheat. The objective of this study was to investigate the effects of designer biochars on biomass productivity and nutrient uptake of winter wheat (Triticum aestivum L.) in a Norfolk's hard setting subsoil layer. Biochars were added to Norfolk's hard setting subsoil layer at the rate of 40 Mg ha(-1). The different sources of biochars were: plant-based (pine chips, PC); animal-based (poultry litter, PL); 50:50 blend (50% PC:50% PL); 80:20 blend (80% PC:20% PL); and hardwood (HW). Aboveground and belowground biomass and nutrient uptake of winter wheat varied significantly (p <= 0.0001) with the different designer biochar applications. The greatest increase in the belowground biomass of winter wheat over the control was from 80:20 blend of PC:PL (81%) followed by HW (76%), PC (59%) and 50:50 blend of PC:PL (9%). However, application of PL resulted in significant reduction of belowground biomass by about 82% when compared to the control plants. The average uptake of P, K, Ca, Mg, Na, Al, Fe, Cu and Zn in both the aboveground and belowground biomass of winter wheat varied remarkably with biochar treatments. Overall, our results showed promising significance for the treatment of a Norfolk's hard setting subsoil layer since designer biochars did improve both aboveground/belowground biomass and nutrient uptake of winter wheat. Published by Elsevier Ltd. C1 [Sigua, G. C.; Novak, J. M.; Watts, D. W.] USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Johnson, M. G.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Spokas, K.] USDA ARS, St Paul, MN USA. RP Sigua, GC (reprint author), USDA ARS, CPSWPRC, 2611 West Lucas St, Florence, SC 29501 USA. EM gilbert.sigua@ars.usda.gov FU United States Department of Agriculture-Agricultural Research Service [60-6657-1-204]; United States Environmental Protection Agency [DE-12-92342301-1] FX The information in this article has been funded through an Interagency Agreement between the United States Department of Agriculture-Agricultural Research Service (60-6657-1-204) and the United States Environmental Protection Agency (DE-12-92342301-1). It has been subject to review by scientists of the USDA-ARS-Coastal Plain Research Laboratory and by the National Health and Environment Effects Research Laboratory's Western Ecology Division and approved for journal submission. Approval does not signify that the contents reflect views of the US EPA, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. We thank Cierra Buckman and Bree Williams for laboratory assistance and for the pine chips supplied by Dr. Carl Trettin of the USFS-Cordsville Station. NR 41 TC 3 Z9 3 U1 4 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2016 VL 142 BP 176 EP 183 DI 10.1016/j.chemosphere.2015.06.015 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX0DZ UT WOS:000365368400025 PM 26112657 ER PT J AU Angeler, DG Allen, CR Garmestani, AS Gunderson, LH Hjerne, O Winder, M AF Angeler, David G. Allen, Craig R. Garmestani, Ahjond S. Gunderson, Lance H. Hjerne, Olle Winder, Monika TI Quantifying the Adaptive Cycle SO PLOS ONE LA English DT Article ID BALTIC SEA; PEG-MODEL; PHYTOPLANKTON; SYSTEMS; RESILIENCE; SUCCESSION; ECOSYSTEM; PLANKTON; COMMUNITIES; MECHANISMS AB The adaptive cycle was proposed as a conceptual model to portray patterns of change in complex systems. Despite the model having potential for elucidating change across systems, it has been used mainly as a metaphor, describing system dynamics qualitatively. We use a quantitative approach for testing premises (reorganisation, conservatism, adaptation) in the adaptive cycle, using Baltic Sea phytoplankton communities as an example of such complex system dynamics. Phytoplankton organizes in recurring spring and summer blooms, a well-established paradigm in planktology and succession theory, with characteristic temporal trajectories during blooms that may be consistent with adaptive cycle phases. We used long-term (1994-2011) data and multivariate analysis of community structure to assess key components of the adaptive cycle. Specifically, we tested predictions about: reorganisation: spring and summer blooms comprise distinct community states; conservatism: community trajectories during individual adaptive cycles are conservative; and adaptation: phytoplankton species during blooms change in the long term. All predictions were supported by our analyses. Results suggest that traditional ecological paradigms such as phytoplankton successional models have potential for moving the adaptive cycle from a metaphor to a framework that can improve our understanding how complex systems organize and reorganize following collapse. Quantifying reorganization, conservatism and adaptation provides opportunities to cope with the intricacies and uncertainties associated with fast ecological change, driven by shifting system controls. Ultimately, combining traditional ecological paradigms with heuristics of complex system dynamics using quantitative approaches may help refine ecological theory and improve our understanding of the resilience of ecosystems. C1 [Angeler, David G.; Hjerne, Olle; Winder, Monika] Stockholm Univ, Dept Ecol Evolut & Plant Sci, SE-10691 Stockholm, Sweden. [Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, SE-75007 Uppsala, Sweden. [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Gunderson, Lance H.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. RP Angeler, DG (reprint author), Stockholm Univ, Dept Ecol Evolut & Plant Sci, SE-10691 Stockholm, Sweden. EM david.angeler@slu.se FU Department of Ecology, Environment and Plant Sciences, Stockholm University; Stockholm University's Strategic Marine Environmental Research Programme on Baltic Ecosystem Adaptive Management (BEAM); BONUS project [BIO-C3]; EU; Swedish Research Council FORMAS [2014-1193]; Swedish Research Council VR [2014-5828] FX Financial support from the Department of Ecology, Environment and Plant Sciences, Stockholm University, and by Stockholm University's Strategic Marine Environmental Research Programme on Baltic Ecosystem Adaptive Management (BEAM) and from the BONUS project BIO-C3, funded jointly by the EU and FORMAS is acknowledged. Additional support was provided by grants from the Swedish Research Councils VR (2014-5828) and FORMAS (2014-1193). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 1 Z9 2 U1 4 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 30 PY 2015 VL 10 IS 12 AR e0146053 DI 10.1371/journal.pone.0146053 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA0TN UT WOS:000367510500127 PM 26716453 ER PT J AU Pruell, RJ Taplin, BK AF Pruell, Richard J. Taplin, Bryan K. TI Carbon and nitrogen isotope ratios of juvenile winter flounder as indicators of inputs to estuarine systems SO MARINE POLLUTION BULLETIN LA English DT Article DE Stable nitrogen isotopes; Stable carbon isotopes; Fish; Winter flounder; Estuaries ID ASSESS HABITAT QUALITY; NARRAGANSETT-BAY; RHODE-ISLAND; STABLE-ISOTOPES; ANTHROPOGENIC NITROGEN; WAQUOIT BAY; PSEUDOPLEURONECTES-AMERICANUS; COASTAL EUTROPHICATION; NUTRIENT ENRICHMENT; DELAWARE ESTUARY AB Stable carbon and nitrogen isotope ratios were measured in young-of-the-year (YOY) winter flounder, Pseudopleuronectes americanus, collected from several Rhode Island, USA estuarine systems. These included three coastal lagoons, an estuarine river and Narragansett Bay. The delta C-13 trends observed along transects in several systems showed isotopically depleted terrestrial signals in the upper reaches of the estuaries. Significant differences (P < 0.05) in delta N-15 were observed among all estuarine systems and these differences correlated (P < 0.01) with human population densities in the watersheds. Although Narragansett Bay has a strong north-south gradient in nutrient concentrations this trend was not reflected in flounder delta N-15. The northernmost station with the highest nutrient concentrations unexpectedly had significantly lower delta N-15 values. Depleted delta N-15 values at this nutrient-rich station may indicate that concentration-dependent fractionation needs to be considered when using nitrogen isotope ratios in biota to monitor anthropogenic nitrogen inputs in systems with high nitrogen loadings. Published by Elsevier Ltd. C1 [Pruell, Richard J.; Taplin, Bryan K.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlant Ecol Div, Narragansett, RI 02882 USA. RP Pruell, RJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlant Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM pruell.richard@epa.gov FU US EPA FX We would like to thank Jennifer Yordy for assistance with the field collection of juvenile winter flounder, Kenneth Miller (Computer Sciences Corp.) for the statistical analyses, Michael Charpentier (Raytheon Corp.) for GIS work and Patricia DeCastro (SRA International, Inc.) for assistance with the graphics. The sample collections were conducted under permit from the Rhode Island Department of Environmental Management. The research for this article was supported by the US EPA, but has not been subject to agency review, and therefore does not necessarily reflect the views of the agency. No official endorsement should be inferred. This is ORD Tracking Number ORD-009821. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 63 TC 0 Z9 0 U1 4 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD DEC 30 PY 2015 VL 101 IS 2 BP 624 EP 631 DI 10.1016/j.marpolbul.2015.10.037 PG 8 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CZ4XY UT WOS:000367107600020 PM 26541984 ER PT J AU Zhao, JJ Al, T Chapman, SW Parker, B Mishkin, KR Cutt, D Wilkin, RT AF Zhao, Jiujiang Al, Tom Chapman, Steven W. Parker, Beth Mishkin, Katherine R. Cutt, Diana Wilkin, Richard T. TI Determination of hexavalent chromium concentrations in matrix porewater from a contaminated aquifer in fractured sedimentary bedrock SO CHEMICAL GEOLOGY LA English DT Article DE Hexavalent chromium; Bedrock; Porewater; Alkaline extraction; Cation exchange; ICP-MS ID GROUNDWATER; SPECIATION; REMEDIATION; SOIL AB A new method for quantification of hexavalent chromium (Cr(VI)) in the porewater of rock core samples from contaminated sedimentary bedrock has been developed here. The method combines alkaline extraction with cation exchange column separation followed by determination of Cr concentrations by inductively coupled plasma mass spectrometry (ICP-MS). A porewater detection limit of 45 mu g/L was determined by performing extractions on uncontaminated samples, and accounts for dilution of porewater volumes by the extraction solution. Recoveries of Cr(VI) in quality control (QC) samples were greater than 90% and there was no significant interference from Cr(III). Relative standard deviations (RSD) were less than 10% for QC samples spiked with Cr(VI), and 2 to 47% (average of 21%) for replicate analyses of core samples. Cr(VI) analyses were conducted on depth-discrete core samples collected at intervals of <0.3 m from sandstone and siltstone bedrock within a contaminated groundwater plume. Groundwater samples were collected using multilevel well ports and were also analyzed for Cr(VI) concentrations. Significant Cr(VI) anomalies were observed in the rock matrix of the core samples. Overall, we observe general agreement in the Cr(VI) concentrations between the samples of immobile rock-matrix porewater and the samples of groundwater which is mobile in rock fractures. This method provides a viable procedure for determination of Cr(VI) concentration in bedrock porewater, and these datasets are valuable for developing conceptual models, assessing plume transport and fate, and for considering remedial options. (C) 2015 Elsevier B.V. All rights reserved. C1 [Zhao, Jiujiang; Al, Tom] Univ New Brunswick, Dept Earth Sci, Fredericton, NB E3B 5A3, Canada. [Chapman, Steven W.; Parker, Beth] Univ Guelph, Sch Engn, Guelph, ON N1G 2W1, Canada. [Mishkin, Katherine R.] US EPA, Superfund Tech Support Sect, US EPA Reg 2, New York, NY USA. [Cutt, Diana] US EPA, Superfund Technol Liaison, Reg Sci Program, Off Res & Dev,EPA Reg 2, New York, NY USA. [Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, New York, NY USA. RP Zhao, JJ (reprint author), Univ Ottawa, Dept Earth & Environm Sci, Ottawa, ON K1N 6N5, Canada. EM jzha4@uottawa.ca FU U.S. EPA; Army Corps of Engineers; University Consortium for Field-Focused Groundwater Contamination Research FX Funding for site activities and support was provided by the U.S. EPA and Army Corps of Engineers. CH2M Hill was the primary site consultant and provided field and logistical support for the core subsampling activities and also provided the groundwater data from the MLS and other site data. Supplemental funding for development of the laboratory methods was provided by the University Consortium for Field-Focused Groundwater Contamination Research (http://g360.uoguelph.ca/consortium). NR 32 TC 1 Z9 1 U1 3 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 EI 1878-5999 J9 CHEM GEOL JI Chem. Geol. PD DEC 25 PY 2015 VL 419 BP 142 EP 148 DI 10.1016/j.chemgeo.2015.10.034 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA CW7UZ UT WOS:000365206200012 ER PT J AU Ottinger, D Averyt, M Harris, D AF Ottinger, Deborah Averyt, Mollie Harris, Deborah TI US consumption and supplies of sulphur hexafluoride reported under the greenhouse gas reporting program SO JOURNAL OF INTEGRATIVE ENVIRONMENTAL SCIENCES LA English DT Article DE Sulphur hexafluoride; SF6; consumption; emissions; potential emissions; supplies ID SF6 AB Under the Greenhouse Gas Reporting Program (GHGRP), the US Environmental Protection Agency (EPA) receives reports of production, imports and exports of SF6 in bulk and inside of electrical equipment. EPA also receives reports of SF6 emissions, consumption and/or related parameters from users of SF6, including manufacturers and users of electrical transmission and distribution equipment, semiconductor manufacturers, and magnesium producers and processers. Based on these reports, EPA estimates the consumption of SF6 by each industry, including facilities that do not report to the GHGRP. In this paper, we compare the consumption estimated based on reports from SF6 suppliers (producers, importers and exporters) to the consumption estimated based on reports from SF6 users, discussing differences and possible reasons for them. We find that in the one year studied, 2012, consumption based on reports from users accounted for 59% of the consumption based on reports from suppliers. We conclude that the uncertainties associated with the consumption estimates are not likely to explain this difference, and that there may be significant uses of SF6 in the US other than manufacturing and use of electrical equipment, semiconductor manufacturing, and magnesium production and processing. C1 [Ottinger, Deborah] Environm Protect Agcy, Off Atmospher Programs, Climate Change Div, Washington, DC USA. [Averyt, Mollie] ICF Int, Burlington, VT USA. [Harris, Deborah] ICF Int, Washington, DC USA. RP Ottinger, D (reprint author), Environm Protect Agcy, Off Atmospher Programs, Climate Change Div, Washington, DC USA. EM ottinger.deborah@epa.gov NR 9 TC 0 Z9 0 U1 1 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1943-815X EI 1943-8168 J9 J INTEGR ENVIRON SCI JI J. Integr. Environ. Sci. PD DEC 18 PY 2015 VL 12 SU 1 SI SI BP 5 EP 16 DI 10.1080/1943815X.2015.1092452 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DF9OL UT WOS:000371690600002 ER PT J AU Ragnauth, SA Creason, J Alsalam, J Ohrel, S Petrusa, JE Beach, RH AF Ragnauth, Shaun A. Creason, Jared Alsalam, Jameel Ohrel, Sara Petrusa, Jeffrey E. Beach, Robert H. TI Global mitigation of non-CO2 greenhouse gases: marginal abatement costs curves and abatement potential through 2030 SO JOURNAL OF INTEGRATIVE ENVIRONMENTAL SCIENCES LA English DT Article DE Non-CO2 greenhouse gases; marginal abatement cost curves; methane; nitrous oxide; hydrofluorocarbons ID EMISSIONS AB Greenhouse gases (GHGs) other than carbon dioxide (CO2) play an important role in the effort to understand and address global climate change. Approximately 25% of Global warming potential-weighted GHG emissions in the year 2005 comprise the non-CO2 GHGs. The report, Global Mitigation of Non-CO(2)Greenhouse Gases: 2010-2030 provides a comprehensive global analysis and resulting data-set of marginal abatement cost curves that illustrate the abatement potential of non-CO2 GHGs by sector and by region. The basic methodology - a bottom-up, engineering cost approach - builds on the baseline non-CO2 emissions projections published by EPA, applying abatement options to the emissions baseline in each sector. The results of the analysis are MAC curves that reflect aggregated breakeven prices for implementing abatement options in a given sector and region. Among the key findings of the report is that significant, cost-effective abatement exists from non-CO2 sources with abatement options that are available today. Without a price signal (i.e. at $0/tCO(2)e), the global abatement potential is greater than 1800million metric tons of CO2 equivalent. Globally, the energy and agriculture sectors have the greatest potential for abatement. Among the non-CO2 GHGs, methane has the largest abatement potential. Despite the potential for project level cost savings and environmental benefits, barriers to mitigating non-CO2 emissions continue to exist. This paper will provide an overview of the methods and key findings of the report. C1 [Ragnauth, Shaun A.; Creason, Jared; Alsalam, Jameel; Ohrel, Sara] US EPA, 1200 Penn Ave NW 6207J, Washington, DC 20460 USA. [Petrusa, Jeffrey E.; Beach, Robert H.] Res Triangle Inst, Res Triangle Pk, NC USA. RP Ragnauth, SA (reprint author), US EPA, 1200 Penn Ave NW 6207J, Washington, DC 20460 USA. EM ragnauth.shaun@epa.gov NR 8 TC 1 Z9 1 U1 6 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1943-815X EI 1943-8168 J9 J INTEGR ENVIRON SCI JI J. Integr. Environ. Sci. PD DEC 18 PY 2015 VL 12 SU 1 SI SI BP 155 EP 168 DI 10.1080/1943815X.2015.1110182 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA DF9OX UT WOS:000371692000001 ER PT J AU Beach, RH Creason, J Ohrel, SB Ragnauth, S Ogle, S Li, CS Ingraham, P Salas, W AF Beach, Robert H. Creason, Jared Ohrel, Sara Bushey Ragnauth, Shaun Ogle, Stephen Li, Changsheng Ingraham, Pete Salas, William TI Global mitigation potential and costs of reducing agricultural non-CO2 greenhouse gas emissions through 2030 SO JOURNAL OF INTEGRATIVE ENVIRONMENTAL SCIENCES LA English DT Article DE Cropland management; soil management; DAYCENT; rice cultivation; methane; DNDC; nitrous oxide; livestock ID NITROUS-OXIDE EMISSIONS; PADDY FIELDS; MODEL; METHANE; SENSITIVITY; SYSTEMS; CHINA; SOIL AB Agricultural emissions account for 53% of 2010 global non-CO2 emissions and are projected to increase substantially over the next 20years, especially in Asia, Latin America and Africa. While agriculture is a substantial source of emissions, it is also generally considered to be a potential source of cost-effective non-CO2 GHG abatement. Previous "bottom-up" analyses provided marginal abatement cost (MAC) curves for use in modeling these options within economy-wide and global mitigation analyses. In this paper, we utilize updated economic and biophysical data and models developed by the US Environmental Protection Agency (EPA) to investigate regional mitigation potential for major sources of agricultural GHG emissions. In addition, we explore mitigation potential available at costs at or below the estimated benefits of mitigation, as represented by the social cost of carbon. Key enhancements over previous regional assessments include incorporation of additional mitigation options, updated baseline emissions projections, greater spatial disaggregation, and development of MAC curves through 2030. For croplands and rice cultivation, biophysical, process-based models (DAYCENT and DNDC) are used to simulate yields and net GHG emissions under baseline and mitigation scenarios while the livestock sector is modeled by applying key mitigation options to baselines compiled by EPA. MAC curves are generated accounting for net GHG reductions, yield effects, livestock productivity effects, commodity prices, labor requirements, and capital costs where appropriate. MAC curves are developed at the regional level and reveal large potential for non-CO2 GHG mitigation at low carbon prices, especially in Asia. C1 [Beach, Robert H.] RTI Int, Res Triangle Pk, NC USA. [Creason, Jared; Ohrel, Sara Bushey; Ragnauth, Shaun] US EPA, Washington, DC 20460 USA. [Ogle, Stephen] Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO 80523 USA. [Li, Changsheng] Univ New Hampshire, Inst Study Earth Oceans & Space, Complex Syst Res Ctr, Durham, NH 03824 USA. [Ingraham, Pete; Salas, William] Appl GeoSolut LLC, Durham, NH USA. RP Beach, RH (reprint author), RTI Int, Res Triangle Pk, NC USA. EM rbeach@rti.org OI Ogle, Stephen/0000-0003-1899-7446 FU US Environmental Protection Agency, Climate Change Division [EP-BPA-12-H-0023, EP-B14H-00217] FX This work was supported by the US Environmental Protection Agency, Climate Change Division [contract number EP-BPA-12-H-0023, Call Order EP-B14H-00217]. The views and opinions of the authors herein do not necessarily state or reflect those of the US government or the US Environmental Protection Agency. NR 43 TC 0 Z9 0 U1 5 U2 18 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1943-815X EI 1943-8168 J9 J INTEGR ENVIRON SCI JI J. Integr. Environ. Sci. PD DEC 18 PY 2015 VL 12 SU 1 SI SI BP 87 EP 105 DI 10.1080/1943815X.2015.1110183 PG 19 WC Environmental Sciences SC Environmental Sciences & Ecology GA DF9ON UT WOS:000371690800001 ER PT J AU Zajicek, P Kolar, M Prucek, R Ranc, V Bednar, P Varma, RS Sharma, VK Zboril, R AF Zajicek, Petr Kolar, Michal Prucek, Robert Ranc, Vaclav Bednar, Petr Varma, Rajender S. Sharma, Virender K. Zboril, Radek TI Oxidative degradation of triazine- and sulfonylurea-based herbicides using Fe(VI): The case study of atrazine and iodosulfuron with kinetics and degradation products SO SEPARATION AND PURIFICATION TECHNOLOGY LA English DT Article DE Ferrate; Permanganate; Herbicides; Pesticides; pH; Removal ID BETA-LACTAM ANTIBIOTICS; WASTE-WATER TREATMENT; FERRATE(VI) OXIDATION; CARBON NANOTUBES; DRINKING-WATER; REMOVAL; IDENTIFICATION; PERFORMANCE; TECHNOLOGY; MECHANISMS AB The occurrence of common herbicides (Atrazine, ATZ and lodosulfuron, IDS), in waters presents potential risk to human and ecological health. The oxidative degradation of ATZ and IDS by ferrate(VI) (FeO42-)-O-VI, Fe(VI) is studied at different pH levels where kinetically observed second-order rate constants (kapp, M-1 s(-1)) decreased with increase in pH from 6.0 to 9.0. The determination of the rate constants for the Fe(VI) species, HFeO4- and FeO42-, with the herbicides using acid-base equilibria of Fe(VI) suggested that the HFeOZ species was largely responsible for the pH dependence behavior of kapp. The title herbicides degraded >90% within 10 min using excess weighted amounts of Fe(VI) over IDS (2:1) ATZ (20:1) and in the pH range of 6.0-9.0. Comparatively, degradations of ATZ and IDS by Mn(VII) were 70% and 40% under same conditions; - showing a superior efficiency of ferrate(VI) in degradation of toxic herbicides. The oxidized products of ATZ and IDS by Fe(VI) at a neutral pH were examined by liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis, which indicated that Fe(VI) attacked on the sulfonamide and alkyl chain moieties of ATZ and IDS, respectively. (C) 2015 Elsevier B.V. All rights reserved. C1 [Zajicek, Petr; Kolar, Michal; Prucek, Robert; Ranc, Vaclav; Zboril, Radek] Palacky Univ, Fac Sci, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Bednar, Petr] Palacky Univ, Fac Sci, Dept Analyt Chem, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Sharma, Virender K.] Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA. RP Sharma, VK (reprint author), Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA. EM vsharma@sph.tamhsc.edu; radek.zboril@upol.cz RI Zboril, Radek/F-5153-2015; OI Sharma, Virender/0000-0002-5980-8675; Zboril, Radek/0000-0002-3147-2196 FU Operational Program Education for Competitiveness, European Social Fund [CZ.1.07/2.3.00/20.0155]; Technology Agency of the Czech Republic "Competence Centers" [TE01020218]; Palacky University [IGA PrF 2014017]; Ministry of Education, Youth and Sports of the Czech Republic [LO1305] FX Authors gratefully acknowledge the support by the Operational Program Education for Competitiveness, European Social Fund (CZ.1.07/2.3.00/20.0155), the support by the Technology Agency of the Czech Republic "Competence Centers" (TE01020218), internal student grant IGA PrF 2014017 of Palacky University and the support by the project LO1305 of the Ministry of Education, Youth and Sports of the Czech Republic. NR 43 TC 3 Z9 3 U1 15 U2 57 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5866 EI 1873-3794 J9 SEP PURIF TECHNOL JI Sep. Purif. Technol. PD DEC 17 PY 2015 VL 156 SI SI BP 1041 EP 1046 DI 10.1016/j.seppur.2015.08.024 PN 3 PG 6 WC Engineering, Chemical SC Engineering GA CY6SB UT WOS:000366538000018 ER PT J AU Gilliam, RC Hogrefe, C Godowitch, JM Napelenok, S Mathur, R Rao, ST AF Gilliam, Robert C. Hogrefe, Christian Godowitch, James M. Napelenok, Sergey Mathur, Rohit Rao, S. Trivikrama TI Impact of inherent meteorology uncertainty on air quality model predictions SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID 4-DIMENSIONAL DATA ASSIMILATION; AREA MESOSCALE MODEL; HORIZONTAL TRANSPORT; ENSEMBLE; SYSTEM; SIMULATIONS; PART; NMC; PERTURBATIONS; COORDINATE AB It is well established that there are a number of different classifications and sources of uncertainties in environmental modeling systems. Air quality models rely on two key inputs, namely, meteorology and emissions. When using air quality models for decision making, it is important to understand how uncertainties in these inputs affect the simulated concentrations. Ensembles are one method to explore how uncertainty in meteorology affects air pollution concentrations. Most studies explore this uncertainty by running different meteorological models or the same model with different physics options and in some cases combinations of different meteorological and air quality models. While these have been shown to be useful techniques in some cases, we present a technique that leverages the initial condition perturbations of a weather forecast ensemble, namely, the Short-Range Ensemble Forecast system to drive the four-dimensional data assimilation in the Weather Research and Forecasting (WRF)-Community Multiscale Air Quality (CMAQ) model with a key focus being the response of ozone chemistry and transport. Results confirm that a sizable spread in WRF solutions, including common weather variables of temperature, wind, boundary layer depth, clouds, and radiation, can cause a relatively large range of ozone-mixing ratios. Pollutant transport can be altered by hundreds of kilometers over several days. Ozone-mixing ratios of the ensemble can vary as much as 10-20 ppb or 20-30% in areas that typically have higher pollution levels. C1 [Gilliam, Robert C.; Hogrefe, Christian; Godowitch, James M.; Napelenok, Sergey; Mathur, Rohit; Rao, S. Trivikrama] US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. [Rao, S. Trivikrama] N Carolina State Univ, Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. RP Rao, ST (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.; Rao, ST (reprint author), N Carolina State Univ, Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. EM Gilliam.robert@epa.gov FU U.S. Environmental Protection Agency FX In accordance with the AGU's Data Policy, data and software used in this paper will be made available upon request from the corresponding author: gilliam.robert@epa.gov. Although this research was funded by the U.S. Environmental Protection Agency and approved for publication, it does not necessarily reflect the Agency's views or politics. Jun Du at NOAA's National Center for Environmental Prediction was instrumental in retrieving the SREF analysis data for the experiment since these historic data are not available on publicly accessible FTP sites. NR 63 TC 1 Z9 1 U1 0 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 16 PY 2015 VL 120 IS 23 DI 10.1002/2015JD023674 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DB3PD UT WOS:000368422700031 ER PT J AU Xing, J Mathur, R Pleim, J Hogrefe, C Gan, CM Wong, DC Wei, C Wang, JD AF Xing, Jia Mathur, Rohit Pleim, Jonathan Hogrefe, Christian Gan, Chuen-Meei Wong, David C. Wei, Chao Wang, Jiandong TI Air pollution and climate response to aerosol direct radiative effects: A modeling study of decadal trends across the northern hemisphere SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ANTHROPOGENIC AEROSOLS; COUPLED METEOROLOGY; UNITED-STATES; PAN EVAPORATION; QUALITY; CHINA; SYSTEM; TEMPERATURE; SIMULATION; TRANSPORT AB Decadal hemispheric Weather Research and Forecast-Community Multiscale Air Quality simulations from 1990 to 2010 were conducted to examine the meteorology and air quality responses to the aerosol direct radiative effects. The model's performance for the simulation of hourly surface temperature, relative humidity, wind speed, and direction was evaluated through comparison with observations from NOAA's National Climatic Data Center Integrated Surface Data. The inclusion of aerosol direct radiative effects improves the model's ability to reproduce the trend in daytime temperature range which over the past two decadeswas increasing in eastern China but decreasing in eastern U.S. and Europe. Trends and spatial and diurnal variations of the surface-level gaseous and particle concentrations to the aerosol direct effect were analyzed. The inclusion of aerosol direct radiative effects was found to increase the surface-level concentrations of SO2, NO2, O-3, SO42-, NO3-, and particulate matter 2.5 in eastern China, eastern U.S., and Europe by 1.5-2.1%, 1-1.5%, 0.1-0.3%, 1.6-2.3%, 3.5-10.0%, and 2.2-3.2%, respectively, on average over the entire 21 year period. However, greater impacts are noted during polluted days with increases of 7.6-10.6%, 6.2-6.7%, 2.0-3.0%, 7.8-9.5%, 11.1-18.6%, and 7.2-10.1%, respectively. Due to the aerosol direct radiative effects, stabilizing of the atmosphere associated with reduced planetary boundary layer height and ventilation leads to an enhancement of pollution. Consequently, the continual increase of aerosol optical depth (AOD) in eastern China leads to an increasing trend in the air quality feedback which exacerbates air pollution, while emission reductions in eastern U.S. and Europe result in a declining trend in both AODs and feedback which make the air pollution control strategies more effective. C1 [Xing, Jia; Mathur, Rohit; Pleim, Jonathan; Hogrefe, Christian; Gan, Chuen-Meei; Wong, David C.; Wei, Chao; Wang, Jiandong] US EPA, Res Triangle Pk, NC 27711 USA. [Wei, Chao] Max Planck Inst Chem, Multiphase Chem Dept, Mainz, Germany. [Wang, Jiandong] Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China. RP Xing, J (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM xing.jia@epa.gov RI wei, chao/E-4379-2011; Wang, Jiandong/O-1863-2015; Pleim, Jonathan Pleim/C-1331-2017 OI Wang, Jiandong/0000-0003-3000-622X; Pleim, Jonathan Pleim/0000-0001-6190-6082 FU Department of Energy Project [IA DE-SC000378]; EPA [IA RW-89-92332601] FX This work was supported in part by an interagency agreement between the Department of Energy Project (IA DE-SC000378) and EPA (IA RW-89-92332601). This research was performed while Jia Xing and Chuen-Meei Gan held a National Research Council Research Associateship Award at U.S. EPA, and Jiandong Wang held a China Scholar Council Award at U.S. EPA. The authors gratefully acknowledge the free availability and use of data sets associated with the NCDC (https://www.ncdc.noaa.gov/isd/data-access) and SURFRAD (http://www.esrl.noaa.gov/gmd/grad/surfrad/) data. All data for this paper are properly cited and referred to in the reference list. NR 48 TC 0 Z9 0 U1 7 U2 23 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 16 PY 2015 VL 120 IS 23 DI 10.1002/2015JD023933 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DB3PD UT WOS:000368422700028 ER PT J AU Cantwell, MG Sullivan, JC Katz, DR Burgess, RM Hubeny, JB King, J AF Cantwell, Mark G. Sullivan, Julia C. Katz, David R. Burgess, Robert M. Hubeny, J. Bradford King, John TI Source determination of benzotriazoles in sediment cores from two urban estuaries on the Atlantic Coast of the United States SO MARINE POLLUTION BULLETIN LA English DT Article DE Emerging contaminant; Benzotriazole; UV stabilizer; Sediment core; Corrosion inhibitor; Persistent chemical ID POLYBROMINATED DIPHENYL ETHERS; TANDEM MASS-SPECTROMETRY; FRESH-WATER SEDIMENTS; IN-HOUSE DUST; WASTE-WATER; UV STABILIZERS; ORGANIC-COMPOUNDS; ULTRAVIOLET STABILIZERS; LIQUID-CHROMATOGRAPHY; TREATMENT-PLANT AB Benzotriazoles (BZTs) are used in a broad range of commercial and industrial products, particularly as metal corrosion inhibitors and as ultraviolet (UV) light stabilizer additives in plastics and polymers. In this study, dated sediment cores from two east coast estuaries were analyzed for commonly used BZTs. In Narragansett Bay, UV stabilizing BZTs (UV-BZTs) were present at high levels from 1961 on, reflecting their patent date, local production and long-term preservation in sediment In Salem Sound, UV-BZTs were present at concentrations consistent with other coastal marine locations not influenced by BZT production. Anticorrosive BZTs (AC-BZTs) were found in both cores, with the highest levels reported to date present in Narragansett Bay, indicating sorption to, and preservation in, sediments. This study revealed that both classes of BZTs have remained structurally intact over time in coastal sediment cores, demonstrating their resistance to degradation and persistence in environmental compartments. Published by Elsevier Ltd. C1 [Cantwell, Mark G.; Katz, David R.; Burgess, Robert M.] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Sullivan, Julia C.] Oak Ridge Inst Sci & Educ, Narragansett, RI 02882 USA. [Hubeny, J. Bradford] Salem State Univ, Dept Geol Sci, Salem, MA 01970 USA. [King, John] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. RP Cantwell, MG (reprint author), US EPA, Off Res & Dev, Narragansett, RI 02882 USA. EM Cantwell.mark@epa.gov FU US Environmental Protection Agency, Office of Research and Development; US Department of Energy; EPA FX The authors thank Drs. Abbey Joyce, Richard Pruell and Mr. Steven Rego for their technical reviews. This research was supported in part by an appointment to the Research Participation Program for the US Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and EPA. This manuscript is contribution ORD-012100 of the Atlantic Ecology Division of the United States Environmental Protection Agency, Office of Research and Development, National Health Effects Environmental Research Laboratory. NR 57 TC 0 Z9 1 U1 5 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD DEC 15 PY 2015 VL 101 IS 1 BP 208 EP 218 DI 10.1016/j.marpolbul.2015.10.075 PG 11 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DA2MV UT WOS:000367630700035 PM 26561444 ER PT J AU Lamparelli, CC Pogreba-Brown, K Verhougstraete, M Sato, MIZ Bruni, AD Wade, TJ Eisenberg, JNS AF Lamparelli, Claudia Conde Pogreba-Brown, Kristen Verhougstraete, Marc Zanoli Sato, Maria Ines Bruni, Antonio de Castro Wade, Timothy J. Eisenberg, Joseph N. S. TI Are fecal indicator bacteria appropriate measures of recreational water risks in the tropics: A cohort study of beach goers in Brazil? SO WATER RESEARCH LA English DT Article DE Diarrheal disease; Recreational waters; Brazil; Tropics; Fecal indicator bacteria ID MARINE BEACH; GASTROINTESTINAL ILLNESS; SAO-PAULO; QUALITY; SAND; EXPOSURE; SURVIVAL; COAST; GASTROENTERITIS; ENUMERATION AB Regulating recreational water exposure to pathogens within the tropics is a major public health and economic concern. Although numerous epidemiological studies estimating the risk to recreational marine water exposure have been conducted since the 1950s, few studies have been done in the tropics. Furthermore, many have suggested that the use of fecal indicator bacteria for monitoring recreational water quality in temperate regions is not appropriate in the tropics. We analyzed a large cohort study of five beaches in Sao Paulo, Brazil, conducted during consecutive weekends in the summer of 1999 that estimated risk to water, sand, and food exposures. Enterococci and Escherichia coli concentrations were measured each day of the study. Elevated risks were estimated for both swimming (OR = 1.36 95% Cl: 1.05-1.58) and sand contact (OR = 1.29 95% Cl 1.05-1.58). A 1 log increase in enterococci concentration was associated with an 11% increase in risk (OR = 1.11 95% Cl: 1.04-1.19). For E. coli a 1-log increase in concentration was associated with 19% increase in risk (OR = 1.19 95% CI: 1.14-1.28). Most countries with beaches in the tropics are lower or middle income countries (LMIC) and rely on tourism as a major source of income. We present data that suggests fecal indicator bacteria such as enterococci are an appropriate indicator of risk in tropical urban settings where contamination is coming from predominantly human sources. Additional studies in tropical settings could help inform and refine guidelines for safe use of recreational waters. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Lamparelli, Claudia Conde] Environm Co Sao Paulo State CETESB, Coastal Water Sect, Sao Paulo, Brazil. [Pogreba-Brown, Kristen] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat, Tucson, AZ 85721 USA. [Verhougstraete, Marc] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Community Environm & Policy, Tucson, AZ 85721 USA. [Zanoli Sato, Maria Ines] Environm Co Sao Paulo State CETESB, Environm Anal Dept, Sao Paulo, Brazil. [Bruni, Antonio de Castro] Environm Co Sao Paulo State CETESB, Vehicle Emiss Anal Sect, Sao Paulo, Brazil. [Wade, Timothy J.] US EPA, Chapel Hill, NC USA. [Eisenberg, Joseph N. S.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA. RP Eisenberg, JNS (reprint author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA. EM clamparelli@sp.gov.br; kpogreba@email.arizona.edu; mverhougstraete@email.arizona.edu; misato@sp.gov.br; abruni@sp.gov.br; wade.tim@epa.gov; jnse@umich.edu OI Verhougstraete, Marc/0000-0003-4154-7531 FU NSF in Sao Paulo, Brazil [1242221] FX The authors thank Alfred Dufour for his valuable comments on an earlier draft of the manuscript and Vince Cabelli for his consultation on the design of the study. We are grateful to the staff members of CETESB who participated in the study, especially the supervisors at the beaches: Ana Cristina Truzzi, Maristela M. de Caires; Elayse M. Hachich; Nilda Fernicola; Anali Epindola M. de Campos; Maria Thereza de Oliveira Filha; Vera Lucia S. Cezaretto; Denise Devechi; Katia Maria Diniz; Rubia Kuno; and Cintia Okamura as well as Cristina Camolez, for her assistance in providing sampling site location information and maps. Initial analysis of these data occurred during an NSF funded institute (Pan-American Advanced Studies Institute (PASI): Linking Microbiology, Engineering, and Mathematics for Water Research) in Sao Paulo, Brazil, July 2013 (Grant #1242221). NR 37 TC 4 Z9 4 U1 5 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD DEC 15 PY 2015 VL 87 BP 59 EP 68 DI 10.1016/j.watres.2015.09.001 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CZ9JD UT WOS:000367413000007 PM 26378732 ER PT J AU Wu, SY Yassine, MH Suidan, MT Venosa, AD AF Wu, Shuyun Yassine, Mohamad H. Suidan, Makram T. Venosa, Albert D. TI Anaerobic biodegradation of soybean biodiesel and diesel blends under methanogenic conditions SO WATER RESEARCH LA English DT Article DE Biodiesel; Anaerobic biodegradation kinetics; Petrodiesel; Inhibition ID DIESEL/BIODIESEL BLENDS; AEROBIC BIODEGRADATION; HEAVY OIL; DEGRADATION; SUBSURFACE; TOXICITY AB Biotransformation of soybean biodiesel and the inhibitory effect of petrodiesel were studied under methanogenic conditions. Biodiesel removal efficiency of more than 95% was achieved in a chemostat with influent biodiesel concentrations up to 2.45 g/L. The kinetics of anaerobic biodegradation of soybean biodiesel B100 (biodiesel only) with different petrodiesel loads was studied using biomass pre-acclimated to B100 and B80 (80% biodiesel and 20% petrodiesel). The results indicated that the biodiesel fraction of the blend could be effectively biodegraded, whereas petrodiesel was not biodegraded at all under methanogenic conditions. The presence of petrodiesel in blends with biodiesel had a greater inhibitory effect on the rate of biodegradation than the biodegradation efficiency (defined as the efficiency of methane production). Both the biodegradation rate coefficient and the methane production efficiency increased almost linearly with the increasing fraction of biodiesel. With the increasing fraction of petrodiesel, the biodegradation rate and efficiency were correlated with the concentration of soluble FAMEs in the water. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wu, Shuyun] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45220 USA. [Yassine, Mohamad H.] Gulf Univ Sci & Technol, Coll Arts & Sci, Dept Math & Nat Sci, Hawally 32093, Kuwait. [Suidan, Makram T.] Amer Univ Beirut, Fac Engn & Architecture, Beirut 11072020, Lebanon. [Venosa, Albert D.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Suidan, MT (reprint author), Amer Univ Beirut, Fac Engn & Architecture, POB 11-0236, Beirut 11072020, Lebanon. EM msuidan@aub.edu.lb RI Yassine, Mohamad/C-1782-2016 OI Yassine, Mohamad/0000-0002-6813-4799 FU U.S. Environmental Protection Agency (U.S. EPA) Oil Spill Research Program [EP-C-11-006, 3-19] FX Funding of this research was made possible through the U.S. Environmental Protection Agency (U.S. EPA) Oil Spill Research Program managed by the Land Remediation and Pollution Control Division of the National Risk Management Research Laboratory, Cincinnati, OH, under Contract No. EP-C-11-006, Work Assignment 3-19. NR 20 TC 3 Z9 3 U1 5 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD DEC 15 PY 2015 VL 87 BP 395 EP 402 DI 10.1016/j.watres.2015.09.024 PG 8 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CZ9JD UT WOS:000367413000041 PM 26454635 ER PT J AU Doyle, E Biales, A Focazio, M Griffin, D Loftin, K Wilson, V AF Doyle, Elizabeth Biales, Adam Focazio, Mike Griffin, Dale Loftin, Keith Wilson, Vickie TI Effect-Based Screening Methods for Water Quality Characterization Will Augment Conventional Analyte-by-Analyte Chemical Methods in Research As Well As Regulatory Monitoring SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Doyle, Elizabeth; Wilson, Vickie] US EPA, Washington, DC 20460 USA. [Biales, Adam] Natl Exposure Res Lib, Washington, DC 20024 USA. [Focazio, Mike; Griffin, Dale] US Geol Survey, Tox Subst Hydrol Program, Reston, VA 20192 USA. [Loftin, Keith] US Geol Survey, Organ Geochem Res Lab, Reston, VA 20192 USA. RP Focazio, M (reprint author), US Geol Survey, Tox Subst Hydrol Program, Reston, VA 20192 USA. EM mfocazio@usgs.gov OI Wilson, Vickie/0000-0003-1661-8481 NR 2 TC 1 Z9 1 U1 0 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2015 VL 49 IS 24 BP 13906 EP 13907 DI 10.1021/es5053254 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ1NK UT WOS:000366872300002 PM 25521837 ER PT J AU Simon, K Alson, J Snapp, L Hula, A AF Simon, Karl Alson, Jeff Snapp, Lisa Hula, Aaron TI Can Transportation Emission Reductions Be Achieved Autonomously? SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Simon, Karl; Alson, Jeff; Snapp, Lisa; Hula, Aaron] US EPA, Off Transportat & Air Qual, Washington, DC 20460 USA. RP Hula, A (reprint author), US EPA, Off Transportat & Air Qual, Washington, DC 20460 USA. EM hula.aaron@epa.gov NR 5 TC 1 Z9 1 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2015 VL 49 IS 24 BP 13910 EP 13911 DI 10.1021/acs.est.5b05396 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ1NK UT WOS:000366872300004 PM 26595155 ER PT J AU Washington, JW Jenkins, TM AF Washington, John W. Jenkins, Thomas M. TI Abiotic Hydrolysis of Fluorotelomer-Based Polymers as a Source of Perfluorocarboxylates at the Global Scale SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYFLUOROALKYL SUBSTANCES; TELOMER ALCOHOLS; VAPOR-PRESSURES; MASS FLOWS; WATER; SOIL; DEGRADABILITY; DEGRADATION; WASTE; PERFLUOROOCTANE AB Fluorotelomer-based polymers (FTPs) are the main product of the fluorotelomer industry. For nearly 10 years, whether FTPs degrade to form perfluorooctanoate (PFOA) and perfluorocarboxylate (PFCA) homologues has been vigorously contested. Here we show that circum-neutral abiotic hydrolysis of a commercial FTP proceeds with half-life estimates of 55-89 years and that base-mediated hydrolysis overtakes neutral hydrolysis at about pH = 10, with a half-life similar to 0.7 of years at pH similar to 12. Considered in light of the large production volume of FTPs and the poor efficacy of conventional treatments for recovery of PFCAs from waste streams, these results suggest that FTPs manufactured to date potentially could increase PFCAs 4- to 8-fold over current oceanic loads, largely depending on the integrity of disposal units to contain PFCAs upon hydrolytic generation from FTPs. C1 [Washington, John W.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Jenkins, Thomas M.] US EPA, Senior Environm Employment Program, Athens, GA 30605 USA. RP Washington, JW (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. EM Washington.john@epa.gov FU USEPA Office of Research Development FX Thanks to Scott Mabury, Keegan Rankin, and Eric Weber for helpful input. This research was funded by the USEPA Office of Research & Development. Views expressed in this paper do not necessarily represent the views or policies of the EPA. Mention of trade names or products does not convey EPA approval, endorsement or recommendation. NR 36 TC 6 Z9 6 U1 4 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2015 VL 49 IS 24 BP 14129 EP 14135 DI 10.1021/acs.est.5b03686 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ1NK UT WOS:000366872300029 PM 26526296 ER PT J AU Breen, MS Long, TC Schultz, BD Williams, RW Richmond-Bryant, J Breen, M Langstaff, JE Devlin, RB Schneider, A Burke, JM Batterman, SA Meng, QY AF Breen, Michael S. Long, Thomas C. Schultz, Bradley D. Williams, Ronald W. Richmond-Bryant, Jennifer Breen, Miyuld Langstaff, John E. Devlin, Robert B. Schneider, Alexandra Burke, Janet M. Batterman, Stuart A. Meng, Qing Yu TI Air Pollution Exposure Model for Individuals (EMI) in Health Studies: Evaluation for Ambient PM2.5 in Central North Carolina SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PARTICULATE MATTER PANEL; NEAR-ROAD EXPOSURES; DIABETIC INDIVIDUALS; PERSONAL EXPOSURE; EXCHANGE-RATES; MESA AIR; NEW-YORK; INDOOR; POLLUTANTS; PARTICLES AB Air pollution health studies of fine particulate matter (diameter <= 2.5 mu m, PM2.5) often use outdoor concentrations as exposure surrogates. Failure to account for variability of indoor infiltration of ambient PM2.5 and time indoors can induce exposure errors. We developed and evaluated an exposure model for individuals (EMI), which predicts five tiers of individual-level exposure metrics for ambient PM2.5 using outdoor concentrations, questionnaires, weather, and time-location information. We linked a mechanistic air exchange rate (AER) model to a mass-balance PM2.5 infiltration model to predict residential AER (Tier 1), infiltration factors (Tier 2), indoor concentrations (Tier 3), personal exposure factors (Tier 4), and personal exposures (Tier 5) for ambient PM2.5. Using cross-validation, individual predictions were compared to 591 daily measurements from 31 homes (Tiers 1-3) and participants (Tiers 4-5) in central North Carolina. Median absolute differences were 39% (0.17 h(-1)) for Tier 1, 18% (0.10) for Tier 2, 20% (2.0 mu g/m(3)) for Tier 3, 18% (0.10) for Tier 4, and 20% (1.8 mu g/m(3)) for Tier 5. The capability of EMI could help reduce the uncertainty of ambient PM2.5 exposure metrics used in health studies. C1 [Breen, Michael S.; Williams, Ronald W.; Burke, Janet M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Long, Thomas C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27709 USA. [Schultz, Bradley D.] US EPA, Res Triangle Pk, NC 27709 USA. [Breen, Miyuld] N Carolina State Univ, Dept Math, Biomath Program, Raleigh, NC 27695 USA. [Langstaff, John E.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27709 USA. [Devlin, Robert B.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. [Schneider, Alexandra] Helmholtz Zentrum Muenchen, Inst Epidemiol 2, German Res Ctr Environm Hlth, Neuherberg, Germany. [Batterman, Stuart A.] Univ Michigan, Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Meng, Qing Yu] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08901 USA. RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. EM michael@epa.gov RI Schneider, Alexandra/B-5347-2014 FU U.S. Environmental Protection Agency (EPA) through its Office of Research and Development [68-D-99-012, CR-828186] FX We thank Michelle Oakes and Kathie Dionisio for their reviews and helpful suggestions. The U.S. Environmental Protection Agency (EPA) through its Office of Research and Development designed, funded, and managed the RTP Panel Study described here under contract 68-D-99-012 to the RTI International and to Shaw University under collaborative agreement CR-828186. Although the manuscript was reviewed by the U.S. EPA and approved for publication, it may not necessarily reflect official Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 55 TC 5 Z9 5 U1 0 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2015 VL 49 IS 24 BP 14184 EP 14194 DI 10.1021/acs.est.5b02765 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ1NK UT WOS:000366872300035 PM 26561729 ER PT J AU Pye, HOT Luecken, DJ Xu, L Boyd, CM Ng, NL Baker, KR Ayres, BR Bash, JO Baumann, K Carter, WPL Edgerton, E Fry, JL Hutzell, WT Schwede, DB Shepson, PB AF Pye, Havala O. T. Luecken, Deborah J. Xu, Lu Boyd, Christopher M. Ng, Nga L. Baker, Kirk R. Ayres, Benjamin R. Bash, Jesse O. Baumann, Karsten Carter, William P. L. Edgerton, Eric Fry, Juliane L. Hutzell, William T. Schwede, Donna B. Shepson, Paul B. TI Modeling the Current and Future Roles of Particulate Organic Nitrates in the Southeastern United States SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID REGIONAL AIR-QUALITY; AEROSOL FORMATION; TROPOSPHERIC DEGRADATION; ISOPRENE PHOTOOXIDATION; ATMOSPHERIC CHEMISTRY; BIOGENIC HYDROCARBONS; CHEMICAL CLIMATOLOGY; NORTHERN-HEMISPHERE; MASS-SPECTROMETRY; REACTIVE NITROGEN AB Organic nitrates are an important aerosol constituent in locations where biogenic hydrocarbon emissions mix with anthropogenic NOx sources. While regional and global chemical transport models may include a representation of organic aerosol from monoterpene reactions with nitrate radicals (the primary source of particle-phase organic nitrates in the Southeast United States), secondary organic aerosol (SOA) models can underestimate yields. Furthermore, SOA parametrizations do not explicitly take into account organic nitrate compounds produced in the gas phase. In this work, we developed a coupled gas and aerosol system to describe the formation and subsequent aerosol-phase partitioning of organic nitrates from isoprene and monoterpenes with a focus on the Southeast United States. The concentrations of organic aerosol and gas-phase organic nitrates were improved when particulate organic nitrates were assumed to undergo rapid (tau = 3 h) pseudohydrolysis resulting in nitric acid and nonvolatile secondary organic aerosol. In addition, up to 60% of less oxidized-oxygenated organic aerosol (LO-OOA) could be accounted for via organic nitrate mediated chemistry during the Southern Oxidants and Aerosol Study (SOAS). A 25% reduction in nitrogen oxide (NO + NO2) emissions was predicted to cause a 9% reduction in organic aerosol for June 2013 SOAS conditions at Centreville, Alabama. C1 [Pye, Havala O. T.; Luecken, Deborah J.; Bash, Jesse O.; Hutzell, William T.; Schwede, Donna B.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Xu, Lu; Boyd, Christopher M.; Ng, Nga L.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Ng, Nga L.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Baker, Kirk R.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Ayres, Benjamin R.; Fry, Juliane L.] Reed Coll, Dept Chem, Portland, OR 97202 USA. [Baumann, Karsten; Edgerton, Eric] Atmospher Res & Anal Inc, Cary, NC 27513 USA. [Carter, William P. L.] Univ Calif Riverside, Coll Engn, Ctr Environm Res & Technol, Riverside, CA 92512 USA. [Shepson, Paul B.] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. RP Pye, HOT (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM pye.havala@epa.gov RI Pye, Havala/F-5392-2012 OI Pye, Havala/0000-0002-2014-2140 FU NSF [AGS-1240604, 1242258]; Southern Company; EPRI; U.S. EPA STAR [RD-83540301, R835410]; EPA STAR [83539901, R835409]; U.S. EPA through its Office of Research and Development FX We thank Kristen Foley, Jon Pleim, Rohit Mathur, Kathleen Fahey, Rob Pinder, Ron Cohen, and Steve Brown for useful discussion. We thank CSC for emission processing, Shaojie Song for GEOS-Chem simulations, William Brune for OH observations, Tran Nguyen and Paul Wennberg (NSF grant AGS-1240604) for CIMS data, and William Brown for ceilometer data. We also thank the SOAS field team including Ann Marie Carlton. SEARCH is sponsored by Southern Company and EPRI. Georgia Tech was supported by NSF Grant 1242258 and U.S. EPA STAR RD-83540301 and R835410. J.L.F. acknowledges EPA STAR 83539901. P.B.S. acknowledges EPA STAR R835409. The U.S. EPA through its Office of Research and Development supported the research described here. It has been subjected to Agency administrative review and approved for publication, but may not necessarily reflect official Agency policy. NR 73 TC 11 Z9 11 U1 13 U2 50 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2015 VL 49 IS 24 BP 14195 EP 14203 DI 10.1021/acs.est.5b03738 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ1NK UT WOS:000366872300036 PM 26544021 ER PT J AU Dunk, JR Woodbridge, B Glenn, EM Davis, RJ Fitzgerald, K Henson, P LaPlante, DW Marcot, BG Noon, BR Raphael, MG Schumaker, NH White, B AF Dunk, Jeffrey R. Woodbridge, Brian Glenn, Elizabeth M. Davis, Raymond J. Fitzgerald, Katherine Henson, Paul LaPlante, David W. Marcot, Bruce G. Noon, Barry R. Raphael, Martin G. Schumaker, Nathan H. White, Brendan TI The scientific basis for modeling Northern Spotted Owl habitat: A response to Loehle, Irwin, Manly, and Merrill SO FOREST ECOLOGY AND MANAGEMENT LA English DT Editorial Material DE Critical Habitat; MaxEnt; Northern Spotted Owl; Relative habitat suitability; Species distribution model; Strix occidentalis caurina ID SPECIES DISTRIBUTION MODELS; POINT PROCESS MODELS; NORTHWESTERN CALIFORNIA; REGIONAL CLIMATE; LOCAL WEATHER; SAMPLE-SIZE; PERFORMANCE; DISTRIBUTIONS; ECOLOGY; OREGON AB The U.S. Fish and Wildlife Service recently revised the recovery plan (USFWS, 2011) and designated Critical Habitat (USFWS, 2012a) for the Northern Spotted Owl (Strix occidentalis caurina). The Critical Habitat designation was based in part on a map of relative habitat suitability that was developed by USFWS (2011, 2012b) for this purpose. Loehle et al. (2015) critiqued the U.S. Fish and Wildlife Service's approach to modeling relative habitat suitability for the Northern Spotted Owl. Here, we respond to Loehle et al.'s assessment, and identify four major shortcomings within it. First, it mischaracterizes the literature on spotted owls and MaxEnt, the species distribution model used by the U.S. Fish and Wildlife Service. Second, it is predicated upon several logic errors that, when resolved, undermine Loehle et al.'s conclusions. Third, it fails to demonstrate that the nesting and roosting site location data used by the U.S. Fish and Wildlife Service is a biased sample. Lastly, Loehle et al.'s claims of significant flaws in analytical methods and ecological inference by the U.S. Fish and Wildlife Service are not convincing. We assert that the U.S. Fish and Wildlife Service's Northern Spotted Owl relative habitat suitability model was in fact scientifically rigorous, and that it met the intended goals that the U.S. Fish and Wildlife Service articulated for their models. (C) 2015 Elsevier B.V. All rights reserved. C1 [Dunk, Jeffrey R.] Humboldt State Univ, Dept Environm Sci & Management, Arcata, CA 95521 USA. [Woodbridge, Brian; Fitzgerald, Katherine] USDI Fish & Wildlife Serv, Yreka Fish & Wildlife Off, Yreka, CA 96097 USA. [Glenn, Elizabeth M.; Henson, Paul; White, Brendan] USDI Fish & Wildlife Serv, Oregon Fish & Wildlife Off, Portland, OR 97266 USA. [Davis, Raymond J.] US Forest Serv, Forestry Sci Lab, Corvallis, OR 97330 USA. [LaPlante, David W.] Nat Resources Geospatial, Montague, CA 96064 USA. [Marcot, Bruce G.] USDA Forest Serv, Pacific Northwest Res Stn, Portland, OR 97205 USA. [Noon, Barry R.] Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80521 USA. [Noon, Barry R.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80521 USA. [Raphael, Martin G.] USDA Forest Serv, Pacific Northwest Res Stn, Olympia, WA 98512 USA. [Schumaker, Nathan H.] US Environm Protect Agcy, Environm Res Lab, Corvallis, OR 97333 USA. RP Dunk, JR (reprint author), Humboldt State Univ, Dept Environm Sci & Management, 1 Harpst St, Arcata, CA 95521 USA. EM Jeffrey.Dunk@humboldt.edu NR 36 TC 1 Z9 1 U1 3 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 EI 1872-7042 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD DEC 15 PY 2015 VL 358 BP 355 EP 360 DI 10.1016/j.foreco.2015.06.035 PG 6 WC Forestry SC Forestry GA CV9MY UT WOS:000364612500034 ER PT J AU Chang, SY Vizuete, W Valencia, A Naess, B Isakov, V Palma, T Breen, M Arunachalam, S AF Chang, Shih Ying Vizuete, William Valencia, Alejandro Naess, Brian Isakov, Vlad Palma, Ted Breen, Michael Arunachalam, Saravanan TI A modeling framework for characterizing near-road air pollutant concentration at community scales SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Dispersion; Air pollution; High-resolution modeling; Traffic; Near-road exposure; R-LINE; METARE; Emissions ID PARTICULATE MATTER PM2.5; ENVIRONMENTAL-HEALTH; DISPERSION MODEL; QUALITY MODELS; NORTH-CAROLINA; LOS-ANGELES; LONG BEACH; EXPOSURE; RESOLUTION; EMISSIONS AB In this study, we combine information from transportation network, traffic emissions, and dispersion model to develop a framework to inform exposure estimates for traffic-related air pollutants (TRAPs) with a high spatial resolution. A Research LINE source dispersion model (R-LINE) is used to model multiple TRAPs from roadways at Census-block level for two U.S. regions. We used a novel Space/Time Ordinary Kriging (STOK) approach that uses data from monitoring networks to provide urban background concentrations. To reduce the computational burden, we developed and applied the METeorologically-weighted Averaging for Risk and Exposure (METARE) approach with R-LINE, where a set of selected meteorological data and annual average daily traffic (AADT) are used to obtain annual averages. Compared with explicit modeling, using METARE reduces CPU-time by 88-fold (46.8 h versus 32 min), while still retaining accuracy of exposure estimates. We show two examples in the Piedmont region in North Carolina (similar to 105,000 receptors) and Portland, Maine (similar to 7000 receptors) to characterize near-road air quality. Concentrations for NOx, PM2.5, and benzene in Portland drop by over 40% within 200 m away from the roadway. The concentration drop in North Carolina is less than that in Portland, as previously shown in an observation-based study, showing the robustness of our approach. Heavy-duty diesel vehicles (HDDV) contribute over 55% of NOx and PM2.5 near interstate highways, while light-duty gasoline vehicles (LDGV) contribute over 50% of benzene to urban areas where multiple roadways intersect. Normalized mean error (NME) between explicit modeling and METARE in Portland ranges from 12.6 to 14.5% and normalized mean bias (NMB) ranges from -12.9 to -11.2%. When considering a static emission rate (i.e. the emission does not have temporal variability), both NME and NMB improved (10.5% and -9.5%). Modeled concentrations in Detroit, Michigan at an array of near-road monitors are within a factor of 2 of observed values for CO but not NOx. (C) 2015 Elsevier B.V. All rights reserved. C1 [Chang, Shih Ying; Valencia, Alejandro; Naess, Brian; Arunachalam, Saravanan] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA. [Chang, Shih Ying; Vizuete, William] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Isakov, Vlad; Breen, Michael] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Palma, Ted] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. RP Arunachalam, S (reprint author), Univ N Carolina, Inst Environm, 100 Europa Dr,Suite 490, Chapel Hill, NC 27517 USA. EM sarav@unc.edu OI vizuete, william/0000-0002-1399-2948 FU U.S. Environmental Protection Agency, through its Office of Research and Development [EP-D-12-044] FX The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded and collaborated in the research described here under Contract No. EP-D-12-044 to the University of North Carolina at Chapel Hill. This paper has been subjected to Agency review and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 52 TC 6 Z9 6 U1 5 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 15 PY 2015 VL 538 BP 905 EP 921 DI 10.1016/j.scitotenv.2015.06.139 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA CU2JD UT WOS:000363348900086 PM 26363146 ER PT J AU Julian, JP Wilgruber, NA de Beurs, KM Mayer, PM Jawarneh, RN AF Julian, Jason P. Wilgruber, Nicholas A. de Beurs, Kirsten M. Mayer, Paul M. Jawarneh, Rana N. TI Long-term impacts of land cover changes on stream channel loss SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Historical land use; Stream channel loss; Landscape planning; Watershed hydrology; Urban ecosystem impacts; River discontinuity ID HEADWATER STREAMS; DYNAMICS; BURIAL; URBANIZATION; ECOSYSTEMS; LANDSCAPE; OKLAHOMA; CARBON; AREA; USA AB Land cover change and stream channel loss are two related global environmental changes that are expanding and intensifying. Here, we examine how different types and transitions of land cover change impact stream channel loss across a large urbanizing watershed. We present historical land cover in the 666-km(2) Lake Thunderbird watershed in central Oklahoma (USA) over a 137 year period and coinciding stream channel length changes for the most recent 70 years of this period. Combining these two datasets allowed us to assess the interaction of land cover changes with stream channel loss. Over this period, the upper third of the watershed shifted from predominantly native grassland to an agricultural landscape, followed by widespread urbanization. The lower two-thirds of the watershed changed from a forested landscape to a mosaic of agriculture, urban, forest, and open water. Most channel length lost in the watershed over time was replaced by agriculture. Urban development gradually increased channel loss and disconnection from 1942 to 2011, particularly in the headwaters. Intensities of channel loss for both agriculture and urban increased over time. The two longest connected segments of channel loss came from the creation of two large impoundments, resulting in 46 km and 25 km of lost stream channel, respectively. Overall, the results from this study demonstrate that multiple and various land-use changes over long time periods can lead to rapid losses of large channel lengths as well as gradual (but increasing) losses of small channel lengths across all stream sizes. When these stream channel losses are taken into account, the environmental impacts of anthropogenic land-use change are compounded. (C) 2015 Elsevier B.V. All rights reserved. C1 [Julian, Jason P.] SW Texas State Univ, Dept Geog, San Marcos, TX 78666 USA. [Wilgruber, Nicholas A.; de Beurs, Kirsten M.] Univ Oklahoma, Dept Geog & Environm Sustainabil, Norman, OK 73019 USA. [Mayer, Paul M.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Jawarneh, Rana N.] Yarmouk Univ, Dept Geog, Irbid, Jordan. RP Julian, JP (reprint author), SW Texas State Univ, Dept Geog, 601 Univ Dr,ELA 139, San Marcos, TX 78666 USA. EM Jason.Julian@txstate.edu RI Zhang, Jianming/A-2994-2011; OI Zhang, Jianming/0000-0001-7053-7696; Jawarneh, Rana/0000-0001-9857-1394; Mayer, Paul/0000-0002-8550-1386 FU University of Oklahoma Foundation; U.S. Environmental Protection Agency NNEMS Award FX The findings of this manuscript are based on the Master's research of Nicholas Wilgruber. This research was supported by a University of Oklahoma Foundation Fellowship and U.S. Environmental Protection Agency NNEMS Award [2012-301]. The information in this document has been subjected to U.S. Environmental Protection Agency peer and administrative review, and it has been approved for publication as a U.S. Environmental Protection Agency document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. We thank Allison Roy, Brock Brown, and two anonymous reviewers for greatly improving earlier drafts of this manuscript. NR 60 TC 3 Z9 3 U1 1 U2 122 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 15 PY 2015 VL 537 BP 399 EP 410 DI 10.1016/j.scitotenv.2015.07.147 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA CR2WI UT WOS:000361191100042 PM 26282774 ER PT J AU White, BM Hall, ES AF White, Brandi M. Hall, Eric S. TI Perceptions of environmental health risks among residents in the "Toxic Doughnut": opportunities for risk screening and community mobilization SO BMC PUBLIC HEALTH LA English DT Article DE Environmental justice; Risk perceptions; Community assessment ID DISPARITIES; MINORITY; JUSTICE AB Background: Surrounded by landfills, and toxic and hazardous facilities, Altgeld Gardens is located in a " toxic doughnut". With high rates of environmentally-related conditions, residents have called for a community-based environmental health assessment to improve overall health in their community. The purpose of this study was to investigate the attitudes and beliefs of environmental health risks of Altgeld's residents which would assist community organizing efforts and provide the groundwork for a community-based environmental health assessment. Methods: A questionnaire was designed and administered to 42 Altgeld residents who also participated in focus groups to assess their perceptions of environmental health risks. Results: All participants were Altgeld residents for at least two years and were fairly representative of the broader community. Physical and social hazards were primarily identified as posing risks to participants' family and the broader community. Physical hazards included the dumping of hazardous waste and landfills; social hazards were crime and drugs. Conclusions: These findings have been useful in community organizing efforts and in program planning for local community-based organizations and public health agencies. The results have also been used to prioritize health and environmental risk issues impacting the community. C1 [White, Brandi M.] Med Univ S Carolina, Coll Hlth Profess, Dept Hlth Profess, Charleston, SC 29425 USA. [Hall, Eric S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP White, BM (reprint author), Med Univ S Carolina, Coll Hlth Profess, Dept Hlth Profess, 151 Rutledge Ave, Charleston, SC 29425 USA. EM whitbm@musc.edu OI Hall, Eric/0000-0002-0528-2014 FU J.B. Hawley Research Award in the Division of Epidemiology & Community Health at the University of Minnesota's School of Public Health FX This project would not have been possible without the contributions of residents of Altgeld Gardens-Murray Homes and staff/volunteers at PCR. The project was funded by the J.B. Hawley Research Award in the Division of Epidemiology & Community Health at the University of Minnesota's School of Public Health. NR 26 TC 0 Z9 0 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 10 PY 2015 VL 15 AR 1230 DI 10.1186/s12889-015-2563-y PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CY6WZ UT WOS:000366550800001 PM 26652846 ER PT J AU Forouzanfar, MH Alexander, L Anderson, HR Bachman, VF Biryukov, S Brauer, M Burnett, R Casey, D Coates, MM Cohen, A Delwiche, K Estep, K Frostad, JJ Astha, KC Kyu, HH Moradi-Lakeh, M Ng, M Slepak, EL Thomas, BA Wagner, J Aasvang, GM Abbafati, C Ozgoren, AA Abd-Allah, F Abera, SF Aboyans, V Abraham, B Abraham, JP Abubakar, I Abu-Rmeileh, NME Aburto, TC Achoki, T Adelekan, A Adofo, K Adou, AK Adsuar, JC Afshin, A Agardh, EE Al Khabouri, MJ Al Lami, FH Alam, SS Alasfoor, D Albittar, MI Alegretti, MA Aleman, AV Alemu, ZA Alfonso-Cristancho, R Alhabib, S Ali, R Ali, MK Alla, F Allebeck, P Allen, PJ Alsharif, U Alvarez, E Alvis-Guzman, N Amankwaa, AA Amare, AT Ameh, EA Ameli, O Amini, H Ammar, W Anderson, BO Antonio, CAT Anwari, P Cunningham, SA Arnlov, J Arsenijevic, VSA Artaman, A Asghar, RJ Assadi, R Atkins, LS Atkinson, C Avila, MA Awuah, B Badawi, A Bahit, MC Bakfalouni, T Balakrishnan, K Balalla, S Balu, RK Banerjee, A Barber, RM Barker-Collo, SL Barquera, S Barregard, L Barrero, LH Barrientos-Gutierrez, T Basto-Abreu, AC Basu, A Basu, S Basulaiman, MO Ruvalcaba, CB Beardsley, J Bedi, N Bekele, T Bell, ML Benjet, C Bennett, DA Benzian, H Bernabe, E Beyene, TJ Bhala, N Bhalla, A Bhutta, ZQA Bikbov, B Bin Abdulhak, AA Blore, JD Blyth, FM Bohensky, MA Basara, BB Borges, G Bornstein, NM Bose, D Boufous, S Bourne, RR Brainin, M Brazinova, A Breitborde, NJ Brenner, H Briggs, ADM Broday, DM Brooks, PM Bruce, NG Brugha, TS Brunekreef, B Buchbinder, R Bui, LN Bukhman, G Bulloch, AG Burch, M Burney, PGJ Campos-Nonato, IR Campuzano, JC Cantoral, AJ Caravanos, J Cardenas, R Cardis, E Carpenter, DO Caso, V Castaneda-Orjuela, CA Castro, RE Catala-Lopez, F Cavalleri, F Ccedil;avlin, A Chadha, VK Chang, JC Charlson, FJ Chen, HL Chen, WQ Chen, ZM Chiang, PP Chimed-Ochir, O Chowdhury, R Christophi, CA Chuang, TW Chugh, SS Cirillo, M Classen, TKD Colistro, V Colomar, M Colquhoun, SM Contreras, AG Cooper, C Cooperrider, K Cooper, LT Coresh, J Courville, KJ Criqui, MH Cuevas-Nasu, L Damsere-Derry, J Danawi, H Dandona, L Dandona, R Dargan, PI Davis, A Davitoiu, DV Dayama, A de Castro, EF De la Cruz-Gongora, V De Leo, D de Lima, G Degenhardt, L del Pozo-Cruz, B Dellavalle, RP Deribe, K Derrett, S Jarlais, DCD Dessalegn, M deVeber, GA Devries, KM Dharmaratne, SD Dherani, MK Dicker, D Ding, EL Dokova, K Dorsey, ER Driscoll, TR Duan, L Durrani, AM Ebel, BE Ellenbogen, RG Elshrek, YM Endres, M Ermakov, SP Erskine, HE Eshrati, B Esteghamati, A Fahimi, S Faraon, EJA Farzadfar, F Fay, DFJ Feigin, VL Feigl, AB Fereshtehnejad, SM Ferrari, AJ Ferri, CP Flaxman, AD Fleming, TD Foigt, N Foreman, KJ Paleo, UF Franklin, RC Gabbe, B Gaffikin, L Gakidou, E Gamkrelidze, A Gankpe, FG Gansevoort, RT Garcia-Guerra, FA Gasana, E Geleijnse, JM Gessner, BD Gething, P Gibney, KB Gillum, RF Ginawi, IAM Giroud, M Giussani, G Goenka, S Goginashvili, K Dantes, HG Gona, P de Cosio, TG Gonzalez-Castell, D Gotay, CC Goto, A Gouda, HN Guerrant, RL Gugnani, HC Guillemin, F Gunnell, D Gupta, R Gupta, R Gutierrez, RA Hafezi-Nejad, N Hagan, H Hagstromer, M Halasa, YA Hamadeh, RR Hammami, M Hankey, GJ Hao, YT Harb, HL Haregu, TN Haro, JM Havmoeller, R Hay, SI Hedayati, MT Heredia-Pi, IB Hernandez, L Heuton, KR Heydarpour, P Hijar, M Hoek, HW Man, HJH Hornberger, JC Hosgood, HD Hoy, DG Hsairi, M Hu, GQ Hu, H Huang, C Huang, JJ Hubbell, BJ Huiart, L Husseini, A Iannarone, ML Iburg, KM Idrisov, BT Ikeda, N Innos, K Inoue, M Islami, F Ismayilova, S Jacobsen, KH Jansen, HA Jarvis, DL Jassal, SK Jauregui, A Jayaraman, S Jeemon, P Jensen, PN Jha, V Jiang, F Jiang, GH Jiang, Y Jonas, JB Juel, K Kan, HD Roseline, 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Man, Howard J. Hoff Hornberger, John C. Hosgood, H. Dean Hoy, Damian G. Hsairi, Mohamed Hu, Guoqing Hu, Howard Huang, Cheng Huang, John J. Hubbell, Bryan J. Huiart, Laetitia Husseini, Abdullatif Iannarone, Marissa L. Iburg, Kim M. Idrisov, Bulat T. Ikeda, Nayu Innos, Kaire Inoue, Manami Islami, Farhad Ismayilova, Samaya Jacobsen, Kathryn H. Jansen, Henrica A. Jarvis, Deborah L. Jassal, Simerjot K. Jauregui, Alejandra Jayaraman, Sudha Jeemon, Panniyammakal Jensen, Paul N. Jha, Vivekanand Jiang, Fan Jiang, Guohong Jiang, Ying Jonas, Jost B. Juel, Knud Kan, Haidong Roseline, Sidibe S. Kany Karam, Nadim E. Karch, Andre Karema, Corine K. Karthikeyan, Ganesan Kaul, Anil Kawakami, Norito Kazi, Dhruv S. Kemp, Andrew H. Kengne, Andre P. Keren, Andre Khader, Yousef S. Khalifa, Shams Eldin Ali Hassan Khan, Ejaz A. Khang, Young-Ho Khatibzadeh, Shahab Khonelidze, Irma Kieling, Christian Kim, Daniel Kim, Sungroul Kim, Yunjin Kimokoti, Ruth W. Kinfu, Yohannes Kinge, Jonas M. Kissela, Brett M. Kivipelto, Miia Knibbs, Luke D. Knudsen, Ann Kristin Kokubo, Yoshihiro Kose, M. Rifat Kosen, Soewarta Kraemer, Alexander Kravchenko, Michael Krishnaswami, Sanjay Kromhout, Hans Ku, Tiffany Defo, Barthelemy Kuate Bicer, Burcu Kucuk Kuipers, Ernst J. Kulkarni, Chanda Kulkarni, Veena S. Kumar, G. Anil Kwan, Gene F. Lai, Taavi Balaji, Arjun Lakshmana Lalloo, Ratilal Lallukka, Tea Lam, Hilton Lan, Qing Lansingh, Van C. Larson, Heidi J. Larsson, Anders Laryea, Dennis O. Lavados, Pablo M. Lawrynowicz, Alicia E. Leasher, Janet L. Lee, Jong-Tae Leigh, James Leung, Ricky Levi, Miriam Li, Yichong Li, Yongmei Liang, Juan Liang, Xiaofeng Lim, Stephen S. Lindsay, M. Patrice Lipshultz, Steven E. Liu, Shiwei Liu, Yang Lloyd, Belinda K. Logroscino, Giancarlo London, Stephanie J. Lopez, Nancy Lortet-Tieulent, Joannie Lotufo, Paulo A. Lozano, Rafael Lunevicius, Raimundas Ma, Jixiang Ma, Stefan Machado, Vasco M. P. MacIntyre, Michael F. Magis-Rodriguez, Carlos Mahdi, Abbas A. 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Pervaiz, Aslam Pesudovs, Konrad Peterson, Carrie B. Petzold, Max Phillips, Michael R. Phua, Hwee Pin Plass, Dietrich Poenaru, Dan Polanczyk, Guilherme V. Polinder, Suzanne Pond, Constance D. Pope, C. Arden Pope, Daniel Popova, Svetlana Pourmalek, Farshad Powles, John Prabhakaran, Dorairaj Prasad, Noela M. Qato, Dima M. Quezada, Amado D. Quistberg, D. Alex A. Racape, Lionel Rafay, Anwar Rahimi, Kazem Rahimi-Movaghar, Vafa Rahman, Sajjad Ur Raju, Murugesan Rakovac, Ivo Rana, Saleem M. Rao, Mayuree Razavi, Homie Reddy, K. Srinath Refaat, Amany H. Rehm, Juergen Remuzzi, Giuseppe Ribeiro, Antonio L. Riccio, Patricia M. Richardson, Lee Riederer, Anne Robinson, Margaret Roca, Anna Rodriguez, Alina Rojas-Rueda, David Romieu, Isabelle Ronfani, Luca Room, Robin Roy, Nobhojit Ruhago, George M. Rushton, Lesley Sabin, Nsanzimana Sacco, Ralph L. Saha, Sukanta Sahathevan, Ramesh Sahraian, Mohammad Ali Salomon, Joshua A. Salvo, Deborah Sampson, Uchechukwu K. Sanabria, Juan R. Sanchez, Luz Maria Sanchez-Pimienta, Tania G. Sanchez-Riera, Lidia Sandar, Logan Santos, Itamar S. Sapkota, Amir Satpathy, Maheswar Saunders, James E. Sawhney, Monika Saylan, Mete I. Scarborough, Peter Schmidt, Juergen C. Schneider, Ione J. C. Schoettker, Ben Schwebel, David C. Scott, James G. Seedat, Soraya Sepanlou, Sadaf G. Serdar, Berrin Servan-Mori, Edson E. Shaddick, Gavin Shahraz, Saeid Levy, Teresa Shamah Shangguan, Siyi She, Jun Sheikhbahaei, Sara Shibuya, Kenji Shin, Hwashin H. Shinohara, Yukito Shiri, Rahman Shishani, Kawkab Shiue, Ivy Sigfusdottir, Inga D. Silberberg, Donald H. Simard, Edgar P. Sindi, Shireen Singh, Abhishek Singh, Gitanjali M. Singh, Jasvinder A. Skirbekk, Vegard Sliwa, Karen Soljak, Michael Soneji, Samir Soreide, Kjetil Soshnikov, Sergey Sposato, Luciano A. Sreeramareddy, Chandrashekhar T. Stapelberg, Nicolas J. C. Stathopoulou, Vasiliki Steckling, Nadine Stein, Dan J. Stein, Murray B. Stephens, Natalie Stoeckl, Heidi Straif, Kurt Stroumpoulis, Konstantinos Sturua, Lela Sunguya, Bruno F. Swaminathan, Soumya Swaroop, Mamta Sykes, Bryan L. Tabb, Karen M. Takahashi, Ken Talongwa, Roberto T. Tandon, Nikhil Tanne, David Tanner, Marcel Tavakkoli, Mohammad Ao, Braden J. Te Teixeira, Carolina M. Rojo, Martha M. Tellez Terkawi, Abdullah S. Texcalac-Sangrador, Jose Luis Thackway, Sarah V. Thomson, Blake Thorne-Lyman, Andrew L. Thrift, Amanda G. Thurston, George D. Tillmann, Taavi Tobollik, Myriam Tonelli, Marcello Topouzis, Fotis Towbin, Jeff Rey A. Toyoshima, Hideaki Traebert, Jeff Erson Tran, Bach X. Trasande, Leonardo Trillini, Matias Trujillo, Ulises Dimbuene, Zacharie Tsala Tsilimbaris, Miltiadis Tuzcu, Emin Murat Uchendu, Uche S. Ukwaja, Kingsley N. Uzun, Selen B. van de Vijver, Steven Van Dingenen, Rita Van Gool, Coen H. Van Os, Jim Varakin, Yuri Y. Vasankari, Tommi J. Vasconcelos, Ana Maria N. Vavilala, Monica S. Veerman, Lennert J. Velasquez-Melendez, Gustavo Venketasubramanian, N. Vijayakumar, Lakshmi Villalpando, Salvador Violante, Francesco S. Vlassov, Vasiliy Victorovich Vollset, Stein Emil Wagner, Gregory R. Waller, Stephen G. Wallin, Mitchell T. Wan, Xia Wang, Haidong Wang, JianLi Wang, Linhong Wang, Wenzhi Wang, Yanping Warouw, Tati S. Watts, Charlotte H. Weichenthal, Scott Weiderpass, Elisabete Weintraub, Robert G. Werdecker, Andrea Wessells, K. Ryan Westerman, Ronny Whiteford, Harvey A. Wilkinson, James D. Williams, Hywel C. Williams, Thomas N. Woldeyohannes, Solomon M. Wolfe, Charles D. A. Wong, John Q. Woolf, Anthony D. Wright, Jonathan L. Wurtz, Brittany Xu, Gelin Yan, Lijing L. Yang, Gonghuan Yano, Yuichiro Ye, Pengpeng Yenesew, Muluken Yentuer, Goekalp K. Yip, Paul Yonemoto, Naohiro Yoon, Seok-Jun Younis, Mustafa Z. Younoussi, Zourkaleini Yu, Chuanhua Zaki, Maysaa E. Zhao, Yong Zheng, Yingfeng Zhou, Maigeng Zhu, Jun Zhu, Shankuan Zou, Xiaonong Zunt, Joseph R. Lopez, Alan D. Vos, Theo Murray, Christopher J. CA GBD 2013 Risk Factors TI Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 SO LANCET LA English DT Article ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY; FINE PARTICULATE MATTER; OUTDOOR AIR-POLLUTION; MALE BRITISH DOCTORS; ALL-CAUSE MORTALITY; LONG-TERM EXPOSURE; BLOOD-PRESSURE; TOBACCO SMOKING AB Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57.2% (95% uncertainty interval [UI] 55.8-58.5) of deaths and 41.6% (40.1-43.0) of DALYs. Risks quantified account for 87.9% (86.5-89.3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11.3 million deaths and 241.4 million DALYs, high systolic blood pressure for 10.4 million deaths and 208.1 million DALYs, child and maternal malnutrition for 1.7 million deaths and 176.9 million DALYs, tobacco smoke for 6.1 million deaths and 143.5 million DALYs, air pollution for 5.5 million deaths and 141.5 million DALYs, and high BMI for 4.4 million deaths and 134.0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. 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[Hao, Yuantao] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China. [Zheng, Yingfeng] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou, Guangdong, Peoples R China. [Haregu, Tilahun Nigatu; van de Vijver, Steven] African Populat & Hlth Res Ctr, Nairobi, Kenya. [Haro, Josep Maria] CIBERSAM, Parc Sanitari St Joan de Deu, Sant Boi De Llobregat, Spain. [Haro, Josep Maria] Univ Barcelona, Barcelona, Spain. [Hedayati, Mohammad T.] Mazandaran Univ Med Sci, Sari, Mazandaran, Iran. [Hijar, Martha] Fdn Entornos AC, Cuernavaca, Morelos, Mexico. [Hoek, Hans W.] Columbia Univ, Dept Epidemiol, New York, NY USA. [Man, Howard J. Hoff] Natl Inst Deafness & Other Commun Disorders, Epidemiol & Stat Program, NIH, Bethesda, MD USA. [Mensah, George A.] NIH, Ctr Translat Res & Implementat Sci, Bethesda, MD USA. [Sampson, Uchechukwu K.] NIH, NHLBI, Bethesda, MD USA. [Hornberger, John C.] Cedar Associates, Menlo Pk, CA USA. [Hosgood, H. Dean] Albert Einstein Coll Med, Bronx, NY USA. 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[Jayaraman, Sudha] Virginia Commonwealth Univ, Richmond, VA USA. [Jeemon, Panniyammakal; Prabhakaran, Dorairaj] Ctr Chron Dis Control, New Delhi, India. [Jiang, Fan] Shanghai Childrens Med Ctr, Tianjin, Peoples R China. [Jiang, Guohong] Tianjin Ctr Dis Control & Prevent, Tianjin, Peoples R China. [Phillips, Michael R.] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China. [Jonas, Jost B.] Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany. [Juel, Knud] Natl Inst Publ Hlth, Copenhagen, Denmark. [She, Jun] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. [Kan, Haidong] Fudan Univ, Shanghai, Peoples R China. [Roseline, Sidibe S. Kany] MARIKANI, Bamako, Mali. [Karam, Nadim E.] Univ Balamand, Beirut, Lebanon. [Karch, Andre] Helmholtz Ctr Infect Res, Dept Epidemiol, Braunschweig, Germany. [Karch, Andre] German Ctr Infect Res, Hannover Braunschweig Site, Braunschweig, Germany. [Karema, Corine K.] Minist Hlth, Malaria & Other Parasit Dis Div, Kigali City, Rwanda. [Karthikeyan, Ganesan; Paul, Vinod K.; Satpathy, Maheswar; Tandon, Nikhil] All India Inst Med Sci, New Delhi, India. [Kaul, Anil] Oklahoma State Univ, Tulsa, OK USA. [Kazi, Dhruv S.] Univ Calif San Francisco, San Francisco, CA USA. [Kemp, Andrew H.; Lotufo, Paulo A.; Polanczyk, Guilherme V.; Santos, Itamar S.] Univ Sao Paulo, Sao Paulo, Brazil. [Kemp, Andrew H.] Univ Sydney, Camperdown, NSW, Australia. [Kengne, Andre P.; Matzopoulos, Richard; Parry, Charles D.] South African Med Res Council, Cape Town, South Africa. [Sliwa, Karen] Univ Cape Town, Fac Hlth Sci, Hatter Inst Cardiovasc Res Africa, Cape Town, South Africa. [Matzopoulos, Richard] Univ Cape Town, Sch Publ Hlth & Family Med, Cape Town, South Africa. [Kengne, Andre P.; Mayosi, Bongani M.; Stein, Dan J.] Univ Cape Town, Cape Town, South Africa. [Keren, Andre] Hadassah Kerem Univ Hosp, Cardiol, Jerusalem, Israel. [Khader, Yousef S.] Jordan Univ Sci & Technol, Irbid, Jordan. [Khalifa, Shams Eldin Ali Hassan] Supreme Council Hlth, Doha, Qatar. [Khan, Ejaz A.] Hlth Serv Acad, Islamabad, Pakistan. [Khan, Ejaz A.] Expanded Programme Immunizat, Islamabad, Pakistan. [Khang, Young-Ho] Seoul Natl Univ, Coll Med, Seoul, South Korea. [Kieling, Christian] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil. [Kim, Daniel] Northeastern Univ, Boston, MA USA. [Kim, Sungroul] Soonchunhyang Univ, Seoul, South Korea. [Kim, Yunjin] Southern Univ Coll, Johor Baharu, Malaysia. [Kimokoti, Ruth W.] Simmons Coll, Boston, MA USA. [Kinfu, Yohannes] Univ Canberra, Canberra, ACT, Australia. [Kissela, Brett M.] Univ Cincinnati, Cincinnati, OH USA. [Kokubo, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka, Japan. [Kosen, Soewarta] Minist Hlth Indonesia, NIHRD, Ctr Community Empowerment Hlth Policy & Human, Jakarta, Indonesia. [Warouw, Tati S.] Minist Hlth Indonesia, NIHRD, Jakarta, Indonesia. [Kravchenko, Michael] Res Ctr Neurol, Moscow, Russia. [Krishnaswami, Sanjay] Oregon Hlth & Sci Univ, Portland, OR USA. [Defo, Barthelemy Kuate] Univ Montreal, Montreal, PQ, Canada. [Kuipers, Ernst J.] Univ Med Ctr, Erasmus MC, Rotterdam, Netherlands. [Kulkarni, Chanda] Rajrajeswari Med Coll & Hosp, Bangalore, Karnataka, India. [Kulkarni, Veena S.] Arkansas State Univ, State Univ, AR USA. [Kwan, Gene F.] Boston Med Ctr, Boston, MA USA. [Lai, Taavi] Fourth View Consulting, Tallinn, Estonia. [Lalloo, Ratilal] Griffith Univ, Sch Dent & Oral Hlth, Gold Coast, Qld, Australia. [Lalloo, Ratilal] Univ Adelaide, Sch Dent, Australian Res Ctr Populat Oral Hlth, Adelaide, SA, Australia. [Lallukka, Tea] Finnish Inst Occupat Hlth, Disabil Prevent Res Ctr, Helsinki, Finland. [Shiri, Rahman] Finnish Inst Occupat Hlth, Helsinki, Finland. [Lallukka, Tea] Univ Helsinki, Fac Med, Helsinki, Finland. [Lam, Hilton] NIH, Inst Hlth Policy & Dev Studies, Manila, Philippines. [Lan, Qing] NCI, Rockville, MD USA. [Lansingh, Van C.] Help Me See Inc, New York, NY USA. [Lansingh, Van C.] Inst Mexicano Oftalmol, Queretaro, Mexico. [Lavados, Pablo M.] Univ Desarrollo, Serv Neurol, Clin Alemana, Santiago, Chile. [Lawrynowicz, Alicia E.] Inst Nacl Epidemiol Dr Juan H Jara, Mar Del Plata, Buenos Aires, Argentina. [Leasher, Janet L.] Nova SE Univ, Coll Optometry, Ft Lauderdale, FL USA. [Lee, Jong-Tae; Yoon, Seok-Jun] Korea Univ, Seoul, South Korea. [Levi, Miriam] Tuscany Reg Ctr Occupat Injuries & Dis, Florence, Italy. [Li, Yichong] Anolinx LLC, Salt Lake City, UT USA. [Liang, Juan; Wang, Yanping; Zhu, Jun] Sichuan Univ, West China Univ Hosp 2, Natl Off Maternal & Child Hlth Surveillance, Chengdu, Peoples R China. [Lindsay, M. Patrice] Heart & Stroke Fdn Canada, Ottawa, ON, Canada. [Lipshultz, Steven E.] Wayne State Univ, Detroit, MI USA. [Lloyd, Belinda K.] Monash Univ, Eastern Hlth Clin Sch, Fitzroy, Vic, Australia. [Lloyd, Belinda K.; Room, Robin] Eastern Hlth, Turning Point Alcohol & Drug Ctr, Fitzroy, Vic, Australia. [Logroscino, Giancarlo] Univ Bari, Bari, Italy. [Lortet-Tieulent, Joannie] Amer Canc Soc, Atlanta, GA USA. [Lunevicius, Raimundas] Aintree Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England. [Ma, Stefan; Phua, Hwee Pin] Minist Hlth Singapore, Singapore, Singapore. [Ma, Stefan] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore. [Magis-Rodriguez, Carlos] Secretaria Salud Mexico, Ctr Nacl Prevenc & Control VIH SIDA, Mexico City, DF, Mexico. [Mahdi, Abbas A.] King Georges Med Univ, Lucknow, Uttar Pradesh, India. [Malekzadeh, Reza] Shariati Hosp, Digest Dis Reseach Inst, Tehran, Iran. [Malekzadeh, Reza] Shiraz Univ Med Sci, Shiraz, Iran. [Mangalam, Srikanth] Tech Stand & Safety Author, Toronto, ON, Canada. [Masiye, Felix] Univ Zambia, Lusaka, Zambia. [Marape, Marape] Botswana Baylor Childrens Clin Ctr Excellence, Gaborone, Botswana. [Marcenes, Wagner] Queen Mary Univ London, London, England. [Meaney, Peter A.] Univ Penn, Pereleman Sch Med, Philadelphia, PA USA. [Martin, Randall V.] Dalhousie Univ, Halifax, NS, Canada. [Marzan, Melvin B.] Univ East Ramon Magsaysay Memorial, Med Ctr, Quezon City, Philippines. [Mashal, Mohammad T.] Minist Publ Hlth, Kabul, Afghanistan. [Mason-Jones, Amanda J.] Univ York, York, N Yorkshire, England. [Mazorodze, Tasara T.] Automot Ind Dev Ctr Eastern Cape, Port Elizabeth, South Africa. [Mckay, Abigail C.] EmergentCorp, Belize City, Belize. [Meaney, Peter A.] Childrens Hosp Philadelphia, Philadelphia, PA USA. [Mehndiratta, Man Mohan] Janakpuri Superspecialty Hosp, New Delhi, India. [Meltzer, Michele] Thomas Jefferson Univ, Philadelphia, PA USA. [Mendoza, Walter] United Nations Populat Fund, Lima, Peru. [Meretoja, Atte] Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland. [Mhimbira, Francis Apolinary] Ifakara Hlth Inst, Bagamoyo, Tanzania. [Miller, Ted R.] Pacific Inst Res & Evaluat, Calverton, MD USA. [Miller, Ted R.] Curtin Univ, Ctr Populat Hlth, Perth, WA, Australia. [Mills, Edward J.] Univ Ottawa, Ottawa, ON, Canada. [Margolis, David J.; Silberberg, Donald H.] Univ Penn, Philadelphia, PA USA. [Mishra, Santosh] SNDT Womens Univ, Populat Educ Resource Ctr, Dept Continuing & Adult Educ & Extens, Bombay, Maharashtra, India. [Ibrahim, Norlinah Mohamed] Univ Kebangsaan Malaysia, Med Ctr, Dept Med, Bandar Tun Razak, Malaysia. [Mohammad, Karzan A.] Univ Salahaddin, Erbil, Iraq. [Mola, Glen L.] Univ Papua New Guinea, Boroko, Papua N Guinea. [Monasta, Lorenzo; Montico, Marcella; Ronfani, Luca] Inst Maternal & Child Hlth, IRCCS Burlo Garofolo, Trieste, Italy. [Moore, Ami R.] Univ N Texas, Denton, TX USA. [Morawska, Lidia] Queensland Univ Technol, Int Lab Air Qual & Hlth, Brisbane, Qld, Australia. [Norman, Rosana E.] Queensland Univ Technol, Inst Hlth Biomed Innovat, Brisbane, Qld, Australia. [Mori, Rintaro] Natl Ctr Child Hlth & Dev, Setagaya Ku, Tokyo, Japan. [Tsilimbaris, Miltiadis] Univ Crete, Dept Med, Iraklion, Greece. [Moschandreas, Joanna] Univ Crete, Iraklion, Greece. [Moturi, Wilkister N.] Egerton Univ, Egerton, Kenya. [Werdecker, Andrea] Competence Ctr Mortal Follow Up German Natl Cohor, Heidelberg, Germany. [Mueller, Ulrich O.; Westerman, Ronny] Fed Inst Populat Res, Wiesbaden, Germany. [Mukaigawara, Mitsuru] Okinawa Chubu Hosp, Okinawa, Japan. [Nahas, Ziad] Amer Univ Beirut, Med Ctr, Beirut, Lebanon. [Naidoo, Kovin S.] Univ KwaZulu Natal, Durban, South Africa. [Naldi, Luigi] Azienda Osped Papa Giovanni XXIII, Bergamo, Italy. [Nand, Devina] Minist Hlth Fiji, Suva, Fiji. [Nangia, Vinay] Suraj Eye Inst, Nagpur, Maharashtra, India. [Neal, Bruce] George Inst Global Hlth, Sydney, NSW, Australia. [Nejjari, Chakib] Fac Med, Fes, Morocco. [Neupane, Sudan P.] Univ Oslo, Oslo, Norway. [Ngalesoni, Frida N.] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. [Ngirabega, Jean de Dieu] East African Community Hlth Res Commiss, Kigali, Rwanda. [Nolla, Joan M.] Hosp Univ Bellvitge, Lhospitalet De Llobregat, Spain. [Nolte, Sandra] Deakin Univ, Melbourne, Vic, Australia. [Vollset, Stein Emil] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway. [Norheim, Ole F.] Univ Bergen, Bergen, Norway. [Norrving, Bo] Lund Univ, Dept Clin Sci, Lund, Sweden. [Nyakarahuka, Luke] Makerere Univ, Kampala, Uganda. [Oh, In-Hwan] Kyung Hee Univ, Seoul, South Korea. [Ohkubo, Takayoshi] Teikyo Univ, Sch Med, Tokyo, Japan. [Olusanya, Bolajoko O.] Ctr Hlth Start Initiat, Ikoyi, Nigeria. [Opio, John Nelson] Lira Municipal Council, Lira Dist Local Govt, Lira, Uganda. [Pagcatipunan, Rodolfo S., Jr.] United Lab Inc, Mandaluyong City, Philippines. [Pandian, Jeyaraj D.] Christian Med Coll Ludhiana, Ludhiana, Punjab, India. [Park, Eun-Kee] Kosin Univ, Coll Med, Busan, South Korea. [Stein, Dan J.] South African Med Res Council, Unit Anxiety & Stress Disorders, Cape Town, South Africa. [Parry, Charles D.] South African Med Res Council, Cape Town, South Africa. [Parry, Charles D.; Seedat, Soraya] Univ Stellenbosch, Cape Town, South Africa. [Stokic, Ljiljana Pejin] Econ Inst, Belgrade, Serbia. [Pereira, David M.] Univ Porto, REQUIMTE, Fac Farm, Dept Quim,Lab Farmacognosia, Oporto, Portugal. [Perez-Padilla, Rogelio] Natl Inst Resp Dis, Mexico City, DF, Mexico. [Perez-Ruiz, Fernando] Hosp Univ Cruces, OSI EE Cruces, Baracaldo, Spain. [Perez-Ruiz, Fernando] Biocruces Hlth Res Inst, Baracaldo, Spain. [Perico, Norberto; Remuzzi, Giuseppe; Trillini, Matias] IRCCS Mario Negri Inst Pharmacol Res, Bergamo, Italy. [Perry, Samuel A. L.] Washington State Dept Hlth, Kent, WA USA. [Pervaiz, Aslam] Postgrad Med Inst, Lahore, Pakistan. [Pesudovs, Konrad] Flinders Univ S Australia, Adelaide, SA, Australia. [Peterson, Carrie B.] Aalborg Univ, Aalborg Esst, Denmark. [Petzold, Max] Hlth Metr Unit, Gothenburg, Sweden. [Petzold, Max] Univ Witwatersrand, Johannesburg, South Africa. [Phillips, Michael R.] Emory Univ, Atlanta, GA USA. [Plass, Dietrich] Fed Environm Agcy, Sect Exposure Assessment & Environm Hlth Indicato, Berlin, Germany. [Poenaru, Dan] McGill Univ, Montreal Childrens Hosp, Montreal, PQ, Canada. [Poenaru, Dan] MyungSung Med Coll, Addis Ababa, Ethiopia. [Pond, Constance D.] Univ Newcastle, Callaghan, NSW 2308, Australia. [Pope, C. Arden] Brigham Young Univ, Provo, UT USA. [Popova, Svetlana; Rehm, Juergen] Ctr Addict & Mental Hlth, Toronto, ON, Canada. [Prasad, Noela M.] Fred Hollows Fdn, Sydney, NSW, Australia. [Qato, Dima M.] Univ Illinois, Coll Pharm, Chicago, IL USA. [Rafay, Anwar; Rana, Saleem M.] Contech Int Hlth Consultants, Lahore, Pakistan. [Rafay, Anwar; Rana, Saleem M.] Contech Sch Publ Hlth, Lahore, Pakistan. [Rahman, Sajjad Ur] Hamad Med Corp, Doha, Qatar. [Raju, Murugesan] Univ Missouri, Columbia, MO USA. [Rakovac, Ivo] WHO Reg Off Europe, Copenhagen, Denmark. [Rao, Mayuree] Brown Univ, Warren Alpert Med Sch, Providence, RI USA. [Razavi, Homie] Ctr Dis Anal, Louisville, CO USA. [Refaat, Amany H.] Suez Canal Univ, Ismailia, Egypt. [Ribeiro, Antonio L.] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil. [Velasquez-Melendez, Gustavo] Univ Fed Minas Gerais, Escola Enfermagem, Belo Horizonte, MG, Brazil. [Riccio, Patricia M.; Sposato, Luciano A.] Univ Western Ontario, Dept Clin Neurol Sci, London Hlth Sci Ctr, London, ON, Canada. [Riederer, Anne] George Washington Univ, Washington, DC USA. [Roca, Anna] MRC Unit, Fajara, Gambia. [Rodriguez, Alina] Mid Sweden Univ, Stersund, Sweden. [Romieu, Isabelle; Straif, Kurt] WHO, IARC, Lyon, France. [Roy, Nobhojit] HBNI Univ, BARC Hosp, Bombay, Maharashtra, India. [Ruhago, George M.; Sunguya, Bruno F.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Sacco, Ralph L.] Univ Miami, Miller Sch Med, Miami, FL USA. [Saha, Sukanta] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia. [Sahathevan, Ramesh] Univ Kebangsaan Malaysia, Med Ctr, Kuala Lumpur, Malaysia. [Sahathevan, Ramesh] Calvary Healthcare Bruce, Canberra, ACT, Australia. [Sanabria, Juan R.] Case Western Reserve Univ, Cleveland, OH USA. [Sanabria, Juan R.] RFU Chicago Med Sch, Canc Treatment Ctr Amer, N Chicago, IL USA. [Sanchez-Riera, Lidia] Univ Zurich, Ctr Ageing & Mobil, Zurich, Switzerland. [Sanchez-Riera, Lidia] City Hosp Waid, Zurich, Switzerland. [Sapkota, Amir] Univ Maryland, Sch Publ Hlth, College Pk, MD USA. [Saunders, James E.] Dartmouth Coll, Dartmouth Hitchcock Med Ctr, Lebanon, NH USA. [Soneji, Samir] Dartmouth Coll, Lebanon, NH USA. [Sawhney, Monika] Marshall Univ, Huntington, WV USA. [Saylan, Mete I.] Novartis Turkey, Istanbul, Turkey. [Schneider, Ione J. C.] Univ Fed Santa Catarina, Florianopolis, SC, Brazil. [Schwebel, David C.; Singh, Jasvinder A.] Univ Alabama Birmingham, Birmingham, AL USA. [Serdar, Berrin] Univ Colorado, Aurora, CO USA. [Shaddick, Gavin] Univ Bath, Bath BA2 7AY, Avon, England. [Shangguan, Siyi] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Shinohara, Yukito] Tachikawa Hosp, Tokyo, Japan. [Shiri, Rahman] Univ Tampere, Sch Hlth Sci, Tampere, Finland. [Shishani, Kawkab] Washington State Univ, Spokane, WA USA. [Shiue, Ivy] Northumbria Univ, Hlth & Life Sci, Newcastle Upon Tyne, Tyne & Wear, England. [Shiue, Ivy] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland. [Sigfusdottir, Inga D.] Reykjavik Univ, Reykjavik, Iceland. [Singh, Abhishek] Int Inst Populat Sci, Bombay, Maharashtra, India. [Soreide, Kjetil] Stavanger Univ Hosp, Stavanger, Norway. [Sreeramareddy, Chandrashekhar T.] Univ Tunku Abdul Rahman, Fac Med & Hlth Sci, Kajang, Cheras, Malaysia. [Stapelberg, Nicolas J. C.] Griffith Univ, Southport, Qld, Australia. [Stathopoulou, Vasiliki] Attikon Univ Hosp, Athens, Greece. [Steckling, Nadine] Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany. [Stroumpoulis, Konstantinos] Alexandra Gen Hosp Athens, Athens, Greece. [Stroumpoulis, Konstantinos] Ctr Hosp Publ Cotentin, Cherbourg, France. [Swaminathan, Soumya] Natl Inst Res TB, Madras, Tamil Nadu, India. [Swaroop, Mamta; Yano, Yuichiro] Northwestern Univ, Chicago, IL USA. [Sykes, Bryan L.] Univ Calif Irvine, Irvine, CA USA. [Tabb, Karen M.] Univ Illinois, Champaign, IL USA. [Talongwa, Roberto T.] Minist Hlth, MINSANTE, Yaounde, Cameroon. [Tanne, David] Chaim Sheba Med Ctr, Tel Hashomer, Israel. [Tanne, David] Tel Aviv Univ, Tel Hashomer, Israel. [Tavakkoli, Mohammad] Westchester Med Ctr, Valhalla, NY USA. [Terkawi, Abdullah S.] Outcomes Res Consortium, Cleveland, OH USA. [Terkawi, Abdullah S.] King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia. 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[Van Gool, Coen H.] Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands. [Van Os, Jim] Maastricht Univ, Med Ctr, Maastricht, Netherlands. [Vasankari, Tommi J.] UKK Inst Hlth Promot Res, Tampere, Finland. [Vasconcelos, Ana Maria N.] Univ Brasilia, Brasilia, DF, Brazil. [Vijayakumar, Lakshmi] VHS SNEHA, Madras, Tamil Nadu, India. [Violante, Francesco S.] Univ Bologna, Bologna, Italy. [Vlassov, Vasiliy Victorovich] Higher Sch Econ, Moscow, Russia. [Wagner, Gregory R.] Natl Inst Occupat Safety & Hlth, Washington, DC USA. [Waller, Stephen G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Wallin, Mitchell T.] Georgetown Univ, Dept Neurol, Arlington, VA USA. [Wallin, Mitchell T.] VA Med Ctr, Washington, DC USA. [Wang, Wenzhi] Beijing Neurosurg Inst, Beijing, Peoples R China. [Weintraub, Robert G.] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia. [Wessells, K. Ryan] Univ Calif Davis, Davis, CA USA. [Westerman, Ronny] German Natl Cohort Consortium, Heidelberg, Germany. [Wilkinson, James D.] Wayne State Univ, Detroit, MI USA. [Williams, Hywel C.] Univ Nottingham, Nottingham, England. [Woldeyohannes, Solomon M.] Univ Gondar, Inst Publ Hlth, Gondar, Ethiopia. [Wong, John Q.] Manila Univ, Ateneo Sch Med & Publ Hlth, Pasig, Philippines. [Woolf, Anthony D.] Royal Cornwall Hosp, Truro, Cornwall, England. [Xu, Gelin] Nanjing Univ, Sch Med, Jinling Hosp, Nanjing, Peoples R China. [Yan, Lijing L.] Duke Kunshan Univ, Kunshan, Peoples R China. [Yang, Gonghuan] Peking Union Med Coll, Beijing, Peoples R China. [Yano, Yuichiro] Jichi Med Sch, Tochigi, Japan. [Yip, Paul] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. [Yonemoto, Naohiro] Natl Ctr Neurol & Psychiat, Kodaira, Tokyo, Japan. [Younis, Mustafa Z.] Jackson State Univ, Jackson, MS USA. [Younoussi, Zourkaleini] Univ Niamey, Niamey, Niger. [Yu, Chuanhua] Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China. [Yu, Chuanhua] Wuhan Univ, Global Hlth Inst, Wuhan, Peoples R China. [Zaki, Maysaa E.] Mansoura Fac Med, Mansoura, Egypt. [Zhao, Yong] Chongqing Med Univ, Chongqing, Peoples R China. [Zhu, Shankuan] Zhejiang Univ, Sch Publ Hlth, Hangzhou, Peoples R China. RP Murray, CJ (reprint author), Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA. EM cjlm@uw.edu RI Balakrishnan, Kalpana/B-6653-2015; Davis, Adrian/E-6022-2015; Nieuwenhuijsen, Mark/C-3914-2017; Alsharif, Ubai/C-6527-2017; Amini, Heresh/B-3076-2010; Lotufo, Paulo/A-9843-2008; Karch, Andre/D-6973-2017; Hedayati, Mohammad T./E-2304-2017; Scott, James/D-5900-2012; Franklin, Richard/H-1731-2012; Giussani, Giorgia/E-8057-2017; Ermakov, Sergey/G-1709-2016; Pereira, David/M-9286-2013; Parry, Charles/A-2906-2009; Kravchenko, Michael/B-2596-2012; Nolte, Sandra/B-7498-2008; Stein, Dan/A-1752-2008; Tonelli, Marcello/B-3028-2009; Lalloo, Ratilal/O-5624-2014; Tillmann, Taavi/R-6026-2016; Salomon, Joshua/D-3898-2009; Beyene, Tariku Jibat/A-6875-2017; Varakin, Yuriy/C-8634-2012; Brenner, Hermann/B-4627-2017; Majdan, Marek/K-5017-2012; Cardis, Elisabeth/C-3904-2017; Sepanlou, Sadaf/H-9343-2016; Ferri, Cleusa/B-2922-2010; Devries, Karen/K-1083-2016; Jacobsen, Kathryn/B-5857-2008; LOGROSCINO, GIANCARLO/K-5148-2016; wang, YA XING/K-9671-2016; Ribeiro, Antonio/C-2707-2009; Hay, Simon/F-8967-2015; Naldi, Luigi/K-6343-2016; Thrift, Amanda/I-6251-2012; Weiderpass, Elisabete/M-4029-2016; Dokova, Klara/N-2448-2016; Montico, Marcella/B-5290-2013; Haro, Josep Maria/D-1423-2011; Monasta, Lorenzo/B-1388-2012; Degenhardt, Louisa/D-4515-2012; Martin, Randall/C-1205-2014; Hankey, Graeme /H-4968-2014; Kaul, Anil/B-2075-2016; Rakovac, Ivo/A-7678-2013; Banerjee, Amitava/D-4381-2014; NORMAN, ROSANA/F-2774-2010; Charlson, Fiona/F-5290-2011; Patten, Scott/B-4434-2011; Fra.Paleo, Urbano/B-8088-2016; OI Balakrishnan, Kalpana/0000-0002-5905-1801; Newton, Charles/0000-0002-6999-5507; Aburto, Tania/0000-0002-6932-9344; Moradi-Lakeh, Maziar/0000-0001-7381-5305; Mhimbira, Francis/0000-0001-8989-6832; Olusanya, Bolajoko/0000-0002-3826-0583; Castaneda-Orjuela, Carlos/0000-0002-8735-6223; Heredia-Pi, Ileana Beatriz/0000-0002-9998-9239; Soreide, Kjetil/0000-0001-7594-4354; Stockl, Heidi/0000-0002-0907-8483; Vlassov, Valentin/0000-0003-2845-2992; Davis, Adrian/0000-0001-7134-7528; Paternina-Caicedo, Angel/0000-0002-6332-5174; Leasher, Janet/0000-0002-8779-5162; Hu, Howard/0000-0002-3676-2707; Nieuwenhuijsen, Mark/0000-0001-9461-7981; Alsharif, Ubai/0000-0002-4024-3950; Amini, Heresh/0000-0002-4825-1322; Lotufo, Paulo/0000-0002-4856-8450; Karch, Andre/0000-0003-3014-8543; Hedayati, Mohammad T./0000-0001-6415-4648; Scott, James/0000-0002-0744-0688; Franklin, Richard/0000-0003-1864-4552; Ermakov, Sergey/0000-0003-1072-1162; Pereira, David/0000-0003-0384-7592; Parry, Charles/0000-0001-9787-2785; Kravchenko, Michael/0000-0001-5187-5518; Nolte, Sandra/0000-0001-6185-9423; Stein, Dan/0000-0001-7218-7810; Lalloo, Ratilal/0000-0001-5822-1269; Tillmann, Taavi/0000-0002-8428-3719; Salomon, Joshua/0000-0003-3929-5515; Beyene, Tariku Jibat/0000-0002-7474-1966; Brenner, Hermann/0000-0002-6129-1572; Majdan, Marek/0000-0001-8037-742X; Sepanlou, Sadaf/0000-0002-3669-5129; Ferri, Cleusa/0000-0002-1815-7685; Devries, Karen/0000-0001-8935-2181; Jacobsen, Kathryn/0000-0002-4198-6246; LOGROSCINO, GIANCARLO/0000-0003-0423-3242; wang, YA XING/0000-0003-2749-7793; Ribeiro, Antonio/0000-0002-2740-0042; Hay, Simon/0000-0002-0611-7272; Naldi, Luigi/0000-0002-3160-2835; Thrift, Amanda/0000-0001-8533-4170; Weiderpass, Elisabete/0000-0003-2237-0128; Montico, Marcella/0000-0003-0377-8232; Haro, Josep Maria/0000-0002-3984-277X; Monasta, Lorenzo/0000-0001-7774-548X; Degenhardt, Louisa/0000-0002-8513-2218; Martin, Randall/0000-0003-2632-8402; Hankey, Graeme /0000-0002-6044-7328; Rakovac, Ivo/0000-0003-3462-2636; Banerjee, Amitava/0000-0001-8741-3411; NORMAN, ROSANA/0000-0002-9742-1957; Charlson, Fiona/0000-0003-2876-5040; Patten, Scott/0000-0001-9871-4041; Fra.Paleo, Urbano/0000-0001-6192-7684; Chen, Honglei/0000-0003-3446-7779; Perez-Ruiz, Fernando/0000-0002-5268-1894; Kissela, Brett/0000-0002-9773-4013; Catala-Lopez, Ferran/0000-0002-3833-9312; Broday, David/0000-0002-6525-3979; Gouda, Hebe/0000-0002-5709-4509; Xu, Gelin/0000-0002-6194-0341; Goto, Atsushi/0000-0003-0669-654X; Kieling, Christian/0000-0001-7691-4149; Goenka, Shifalika/0000-0001-6993-2883; Sreeramareddy, Chandrashekhar/0000-0002-5693-7631; Soshnikov, Sergey/0000-0002-6983-7066; assadi, reza/0000-0002-5016-2994; Heydarpour, Pouria/0000-0001-5644-7555; Vlassov, Vasiliy/0000-0001-5203-549X; Hoek, Hans/0000-0001-6353-5465; Santos, Itamar/0000-0003-3212-8466; Villalpando, Salvador/0000-0001-6429-3816; Borges, Guilherme/0000-0002-3269-0507; Miller, Ted/0000-0002-0958-2639; Giussani, Giorgia/0000-0003-2460-3095; Leung, Ricky/0000-0002-2852-6771; London, Stephanie/0000-0003-4911-5290; Sindi, Shireen/0000-0002-3786-0552; Gething, Peter/0000-0001-6759-5449; Husseini, Abdullatif/0000-0001-8767-5956; Benjet, Corina/0000-0002-4569-6094; Gabbe, Belinda/0000-0001-7096-7688; Bernabe, Eduardo/0000-0002-1858-3713; Prabhakaran, Dorairaj/0000-0002-3172-834X; Neupane, Sudan Prasad/0000-0002-7389-4178; Khang, Young-Ho/0000-0002-9585-8266; Kemp, Andrew/0000-0003-1146-3791; Erskine, Holly/0000-0003-3119-9211; Aboyans, Victor/0000-0002-0322-9818 FU Bill AMP; Melinda Gates Foundation FX Funding Bill & Melinda Gates Foundation. NR 86 TC 238 Z9 252 U1 124 U2 294 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD DEC 5 PY 2015 VL 386 IS 10010 BP 2287 EP 2323 DI 10.1016/S0140-6736(15)00128-2 PG 37 WC Medicine, General & Internal SC General & Internal Medicine GA CX8ZB UT WOS:000365993200031 ER PT J AU Fawcett, AA Iyer, GC Clarke, LE Edmonds, JA Hultman, NE McJeon, HC Rogelj, J Schuler, R Alsalam, J Asrar, GR Creason, J Jeong, M McFarland, J Mundra, A Shi, WJ AF Fawcett, Allen A. Iyer, Gokul C. Clarke, Leon E. Edmonds, James A. Hultman, Nathan E. McJeon, Haewon C. Rogelj, Joeri Schuler, Reed Alsalam, Jameel Asrar, Ghassem R. Creason, Jared Jeong, Minji McFarland, James Mundra, Anupriya Shi, Wenjing TI Can Paris pledges avert severe climate change? SO SCIENCE LA English DT Editorial Material C1 [Fawcett, Allen A.; Alsalam, Jameel; Creason, Jared; McFarland, James] US EPA, Washington, DC 20460 USA. [Iyer, Gokul C.; Clarke, Leon E.; Edmonds, James A.; McJeon, Haewon C.; Asrar, Ghassem R.; Jeong, Minji; Mundra, Anupriya; Shi, Wenjing] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA. [Iyer, Gokul C.; Clarke, Leon E.; Edmonds, James A.; McJeon, Haewon C.; Asrar, Ghassem R.; Jeong, Minji; Mundra, Anupriya; Shi, Wenjing] Univ Maryland, College Pk, MD 20740 USA. [Hultman, Nathan E.] Univ Maryland, Sch Publ Policy, College Pk, MD 20742 USA. [Rogelj, Joeri] Int Inst Appl Syst Anal, Energy Program, A-2361 Laxenburg, Austria. [Schuler, Reed] US Dept State, Washington, DC 20520 USA. RP Iyer, GC (reprint author), Council Environm Qual, Washington, DC 20506 USA. EM gokul.iyer@pnnl.gov NR 13 TC 18 Z9 19 U1 2 U2 34 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD DEC 4 PY 2015 VL 350 IS 6265 BP 1168 EP 1169 DI 10.1126/science.aad5761 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX4WG UT WOS:000365700500045 PM 26612835 ER PT J AU Berry, WJ Reinert, SE Gallagher, ME Lussier, SM Walsh, E AF Berry, Walter J. Reinert, Steven E. Gallagher, Meghan E. Lussier, Suzanne M. Walsh, Eric TI Population Status of the Seaside Sparrow in Rhode Island: A 25-Year Assessment SO NORTHEASTERN NATURALIST LA English DT Article ID SEA-LEVEL RISE; SALT-MARSH; BIRDS AB To assess long-term changes in the population status of breeding Ammodramus maritimus (Seaside Sparrow) in Rhode Island, we repeated surveys conducted in 1982 by Stoll and Golet (1983). In June and July of 2007 and 2008, we surveyed 19 of Rhode Island's largest salt marshes. Seaside Sparrow abundance had declined at 9 of 11 marshes where the species was present in 1982, and we detected no sparrows at 4 smaller (< 20 ha) marshes where they were present in 1982. Seaside Sparrow abundance increased at 3 marshes, including 1 at which the birds were not detected in 1982. We used aerial photographs to quantify changes in marsh size and human development within 150-m and 1-km buffers surrounding each marsh. From 1981 to 2008, the overall average number of structures within the 150-m and 1-km buffers increased by 37% and 66%, respectively. Concomitantly, salt-marsh area decreased by an overall average of 11%. Seaside Sparrow abundance was related to marsh size, but our analyses did not detect a statistical relationship of landscape or habitat-loss variables with the decline in sparrows. The Seaside Sparrow is currently classified as a species of concern in Rhode Island. However, given the population decline we documented, and the impending threat to salt-marsh habitats imposed by rising sea levels, we suggest that the classification be reassessed now and periodically in the future, and that monitoring efforts for the species be continued. C1 [Berry, Walter J.; Gallagher, Meghan E.; Lussier, Suzanne M.; Walsh, Eric] US EPA, 27 Tarzwell Dr, Narragansett, RI 02882 USA. RP Berry, WJ (reprint author), US EPA, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM berry.walter@epa.gov FU US Environmental Protection Agency FX We thank P. Paton and C. Elphick for their assistance with experimental design. S. Paton and E. King helped with access to several US Fish and Wildlife Service properties. We thank J. Heltshe for his statistical guidance. A. Kuhn helped with statistics and modeling. M. Charpentier helped with GIS. B. Sherman, E. Dettmann, A. Smith, E. Blomberg, P. Capobianco, L. Carberry, R. Emerson, R. McKinney, F. Golet, T. Gleason, W. Munns, K. Raposa, C. Trocki, M. Tucker, L. Vandeveer, K. Winiarski, K. McKeton, and C. Powell collected sparrow-count data without which this study could not have been completed. T. Auer, J. Grear, R. McKinney, and P. Paton commented on earlier versions of the manuscript. Finally, we would like to thank F. Golet for maps, data, and sage advice. Without his cooperation and guidance, this project would not have been possible. Although the research described in this article has been funded wholly by the US Environmental Protection Agency, it has not been subjected to internal review, and therefore, it does not necessarily reflect the views of the Agency. This is contribution number ORD-008919 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency. NR 36 TC 2 Z9 2 U1 3 U2 7 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1092-6194 EI 1938-5307 J9 NORTHEAST NAT JI Northeast. Nat PD DEC PY 2015 VL 22 IS 4 BP 658 EP 671 DI 10.1656/045.022.0403 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8PP UT WOS:000370899000002 ER PT J AU McKinney, RA Raposa, KB Trocki, CL AF McKinney, Richard A. Raposa, Kenneth B. Trocki, Carol L. TI Status and Distribution of Wintering Waterfowl in Narragansett Bay, Rhode Island, 2005-2014 SO NORTHEASTERN NATURALIST LA English DT Article ID DECLINING SCAUP POPULATIONS; HABITAT ASSOCIATIONS; ESTUARY; DUCKS; DISTURBANCE; ABUNDANCE; REFUGES; LAKE AB Surveys of wintering waterfowl can aid in both identifying estuarine habitats currently being used by species of conservation concern so that the sites can be targeted for protection and restoration, and in providing a baseline assessment from which the effects of future changes in wintering habitat can be assessed. In an effort to better understand the local distribution of wintering waterfowl during the period 2005-2014, we undertook a study of waterfowl abundance and distribution in Narragansett Bay, RI, a moderate-sized estuary located in the northeastern US within the Atlantic Flyway. Overall waterfowl abundance in the Bay ranged from 15,002 individuals in 2006 to 26,163 individuals in 2010 and averaged 20,062 +/- 3393 individuals over the 10-y period. Species richness ranged from 1.80 to 10.8 per site; most of the sites with high species richness were located in the Upper Bay. Based on our counts from 67 ground locations, the Narragansett Bay waterfowl community was dominated by Aythya affinis (Lesser Scaup) and A. marila (Greater Scaup), Branta bernicla (Brant), and Branta canadensis (Canada Geese) over the survey period. Waterfowl-community composition indicated that the Upper Bay, an environment characterized by low wave-energy, shallow coves, sheltered embayments, and salt marshes, supported mostly dabbling ducks, geese, and swans. The Lower Bay, an environment characterized by higher wave-energy, rocky shorelines, and deeper open-water habitats, supported mostly sea ducks and other diving-duck species. Abundance over the survey period was relatively stable, and observed patterns of waterfowl distribution suggest that conservation actions to maintain shallow-water habitats, including efforts to protect and restore salt marsh habitat, will help to maintain resources needed by many of the waterfowl species wintering in the Bay. C1 [McKinney, Richard A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Raposa, Kenneth B.] Narragansett Bay Natl Estuarine Res Reserve, Prudence Isl, RI 02872 USA. [Trocki, Carol L.] Univ Rhode Isl, Dept Nat Resources Sci, Kingston, RI 02881 USA. RP McKinney, RA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM mckinney.rick@epa.gov FU US Environmental Protection Agency FX The concept for the Narragansett Bay Winter Waterfowl Survey originated with Scott McWilliams and Peter Paton; they were instrumental in its development and implementation. Many thanks also to those who coordinated surveys of the various sections over the years, including W. Berry, M. Chintala, T. Gleason, H. Hopkins, R. Kenney, W. Munns, B. Sherman, and K. Vigness-Raposa. We are grateful to the many people who participated in the survey during the 10 years since its inception who are too numerous to mention. We thank A. Oczkowski, R. Pruell, and C. Glinka for their reviews and comments on earlier versions of the manuscript. Mention of trade names or commercial products does not constitute endorsement or recommendation. Although the research described in this article has been funded wholly by the US Environmental Protection Agency, it has not been subjected to Agency-level review; therefore, it does not necessarily reflect the views of the Agency. This is ORD Tracking Number ORD-0011584 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency. NR 34 TC 0 Z9 0 U1 5 U2 13 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1092-6194 EI 1938-5307 J9 NORTHEAST NAT JI Northeast. Nat PD DEC PY 2015 VL 22 IS 4 BP 730 EP 745 DI 10.1656/045.022.0410 PG 16 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8PP UT WOS:000370899000007 ER PT J AU Collins, SE Flotemersch, JE Swecker, CD Jones, TG AF Collins, Sean E. Flotemersch, Joseph E. Swecker, Casey D. Jones, Thomas G. TI Effectiveness of a Stream-Restoration Effort Using Natural Material Instream Structures SO SOUTHEASTERN NATURALIST LA English DT Article ID RIVER RESTORATION; SEDIMENTS; PATTERNS; ECOLOGY AB The substrata of fluvial systems can be altered by human disturbance in watersheds. This disturbance often results in a reduction of habitat diversity and subsequent reductions in species diversity. Restoration efforts in impacted areas require a thorough understanding of the characteristics of exemplary stream habitat in the region as well as habitat requirements of taxa targeted by specific restoration efforts. The Little Coal River, WV, has historically been disturbed by various land-use practices resulting in near homogeneity of the riverbed substratum such that it is composed almost everywhere primarily of fine-particle or sand-substrate classes. Restoration of an 8-km section of the Little Coal River was attempted with the installation of a series of natural material instream-structures. We monitored the riverbed substratum, including sediment size-class data, prior to and after installation of these structures for a 2-year period to evaluate their effectiveness in restoring overall habitat heterogeneity. Our GIS analysis of the data suggested that approximately 80% of the riverbed substratum was composed of fine-particle or sand substrate classes prior to the natural material structure addition. After 2 years, these 2 substrate classes had decreased by nearly 25%, suggesting that restoration efforts reduced the overall percent composition of fine-particle and sand-substrate classes and increased overall habitat heterogeneity. Our analysis of these data indicate that the natural material instream structures installed in the Little Coal River achieved the objective of promoting downstream movement of some fineparticle and sand substrate that characterized the system (i.e., via sediment transport) and increased substratum heterogeneity. C1 [Collins, Sean E.] Lees McRae Coll, Div Sci & Math, Banner Elk, NC 28604 USA. [Flotemersch, Joseph E.] US EPA, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. [Swecker, Casey D.] Environm Solut & Innovat Inc, Cincinnati, OH 45232 USA. [Jones, Thomas G.] Marshall Univ, Dept Integrated Sci & Technol, Huntington, WV 25755 USA. RP Flotemersch, JE (reprint author), US EPA, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. EM flotemersch.joseph@epa.gov FU West Virginia Department of Environmental Protection; Coal River Group, a Wieman Wendel Benedict Research Award from the University of Cincinnati; USEPA FX Funding sources for this project included a grant to Marshall University from the West Virginia Department of Environmental Protection and the Coal River Group, a Wieman Wendel Benedict Research Award from the University of Cincinnati to S.E. Collins, and collaborative development support from the USEPA. We thank Jo Garofalo, Alex Hall, Roger Wolfe, Dennis Stottlemyer, Randy Huffman, and anonymous reviewers for comments on an earlier manuscript draft. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency. NR 33 TC 0 Z9 0 U1 5 U2 15 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD DEC PY 2015 VL 14 IS 4 BP 612 EP 622 DI 10.1656/058.014.0403 PG 11 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8NL UT WOS:000370892600002 ER PT J AU Yuen, T Park, AN Seifer, SD Payne-Sturges, D AF Yuen, Tina Park, Alice N. Seifer, Sarena D. Payne-Sturges, Devon TI A Systematic Review of Community Engagement in the US Environmental Protection Agency's Extramural Research Solicitations: Implications for Research Funders SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Review ID PARTICIPATORY RESEARCH; ADVISORY BOARDS; HEALTH AB Objectives. We systematically reviewed the Environmental Protection Agency, National Center for Environmental Research's (NCER's) requests for applications (RFAs) and identified strategies that NCER and other funders can take to bolster community engagement. Methods. We queried NCER's publically available online archive of funding opportunities from fiscal years 1997 to 2013. From an initial list of 211 RFAs that met our inclusion criteria, 33 discussed or incorporated elements of community engagement. We examined these RFAs along 6 dimensions and the degree of alignments between them. Results. We found changes over time in the number of RFAs that included community engagement, variations in how community engagement is defined and expected, inconsistencies between application requirements and peer review criteria, and the inclusion of mechanisms supporting community engagement in research. Conclusions. The results inform a systematic approach to developing RFAs that support community engagement in research. C1 [Yuen, Tina] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA. [Park, Alice N.; Seifer, Sarena D.] Community Campus Partnerships Hlth, Seattle, WA USA. [Payne-Sturges, Devon] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA. RP Payne-Sturges, D (reprint author), Univ Maryland, Maryland Inst Appl Environm Hlth, 2234L Sch Publ Hlth,255 Valley Dr, College Pk, MD 20742 USA. EM dps1@umd.edu FU US Environmental Protection Agency (EPA); Association of Schools and Programs of Public Health [X3-83388101]; EPA [EP-W-09-11, SRAS000772] FX This work was supported by the US Environmental Protection Agency (EPA) and the Association of Schools and Programs of Public Health (cooperative agreement X3-83388101) and was partly funded by the EPA (contract EP-W-09-11, task order 116, subcontract SRAS000772). NR 41 TC 0 Z9 0 U1 3 U2 6 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2015 VL 105 IS 12 BP E44 EP E52 DI 10.2105/AJPH.2015.302811 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DC4BB UT WOS:000369163600011 PM 26469656 ER PT J AU Heinrichs, JA Lawler, JJ Schumaker, NH Wilsey, CB Bender, DJ AF Heinrichs, Julie A. Lawler, Joshua J. Schumaker, Nathan H. Wilsey, Chad B. Bender, Darren J. TI Divergence in sink contributions to population persistence SO CONSERVATION BIOLOGY LA English DT Article DE Dipodomys ordii; ecological traps; population persistence; sink contributions; source-sink dynamics; spatially explicit individual-based model; Strix occidentalis caurina; Vireo atricapilla ID HABITAT SELECTION; ECOLOGICAL TRAPS; DYNAMICS; LANDSCAPES; QUALITY AB Population sinks present unique conservation challenges. The loss of individuals in sinks can compromise persistence; but conversely, sinks can improve viability by improving connectivity and facilitating the recolonization of vacant sources. To assess the contribution of sinks to regional population persistence of declining populations, we simulated source-sink dynamics for 3 very different endangered species: Black-capped Vireos (Vireo atricapilla) at Fort Hood, Texas, Ord's kangaroo rats (Dipodomys ordii) in Alberta, and Northern Spotted Owls (Strix occidentalis caurina) in the northwestern United States. We used empirical data from these case studies to parameterize spatially explicit individual-based models. We then used the models to quantify population abundance and persistence with and without long-term sinks. The contributions of sink habitats varied widely. Sinks were detrimental, particularly when they functioned as strong sinks with few emigrants in declining populations (e.g., Alberta's Ord's kangaroo rat) and benign in robust populations (e.g., Black-capped Vireos) when Brown-headed Cowbird (Molothrus ater) parasitism was controlled. Sinks, including ecological traps, were also crucial in delaying declines when there were few sources (e.g., in Black-capped Vireo populations with no Cowbird control). Sink contributions were also nuanced. For example, sinks that supported large, variable populations were subject to greater extinction risk (e.g., Northern Spotted Owls). In each of our case studies, new context-dependent sinks emerged, underscoring the dynamic nature of sources and sinks and the need for frequent re-assessment. Our results imply that management actions based on assumptions that sink habitats are generally harmful or helpful risk undermining conservation efforts for declining populations. C1 [Heinrichs, Julie A.; Lawler, Joshua J.; Wilsey, Chad B.] Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA. [Schumaker, Nathan H.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA. [Bender, Darren J.] Univ Calgary, Dept Geog, Calgary, AB T2N 1N4, Canada. RP Heinrichs, JA (reprint author), Univ Washington, Sch Environm & Forest Sci, POB 352100, Seattle, WA 98195 USA. EM jheinrx@u.washington.edu RI Heinrichs, Julie/D-2927-2016 OI Heinrichs, Julie/0000-0001-7733-5034 FU Strategic Environmental Research and Development Program (SERDP) [RC-2120]; U.S. Environmental Protection Agency FX This work was funded by the Strategic Environmental Research and Development Program (SERDP) as part of project RC-2120. D. Cimprich, D. Gummer, R. Dzenkiw, and T. Nogeire provided valuable expertise during model construction and analysis. The information in this document was also funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 36 TC 1 Z9 1 U1 3 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-8892 EI 1523-1739 J9 CONSERV BIOL JI Conserv. Biol. PD DEC PY 2015 VL 29 IS 6 BP 1674 EP 1683 DI 10.1111/cobi.12540 PG 10 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DB2JT UT WOS:000368334800020 PM 26032147 ER PT J AU Rundel, CW Schliep, EM Gelfand, AE Holland, DM AF Rundel, Colin W. Schliep, Erin M. Gelfand, Alan E. Holland, David M. TI A data fusion approach for spatial analysis of speciated PM2.5 across time SO ENVIRONMETRICS LA English DT Article DE downscaling; latent process; Markov chain Monte Carlo; multi-level model; tobit (truncated) Gaussian process ID NUMERICAL-MODELS; COREGIONALIZATION; DOWNSCALER; MORTALITY; NICKEL; OUTPUT; SPACE; AIR AB PM2.5 exposure is linked to a number of adverse health effects such as lung cancer and cardiovascular disease. However, PM2.5 is a complex mixture of different species whose composition varies substantially in both space and time. An open question is how these constituent species contribute to the overall negative health outcomes seen from PM2.5 exposure. To this end, the Environmental Protection Agency as well as other federal, state, and local organization monitor total PM2.5 along with its primary species on a national scale. From an epidemiological perspective, there is a need to develop effective methods that will allow for the spatially and temporally sparse observations to be used to predict exposures for locations across the entire United States. Toward this objective, we have collected data from three separate monitoring station networks as well as output from a deterministic atmospheric computer model. We introduce a novel multi-level speciated PM2.5 model, which captures the following features: (1) it fuses data from three monitoring networks; (2) it simultaneously models each of the five primary components of PM2.5 from each network along with the computer model output; (3) it introduces species and network level measurement error models as well as total PM2.5 measurement error models, all varying around the respective latent true levels; (4) it incorporates an unobserved "other" species component as well as a sum constraint such that the total is physically consistent (i.e., total must be equal to the sum of the primary species and "other"), which is not always the case with the observed data. Copyright (C) 2015 John Wiley & Sons, Ltd. C1 [Rundel, Colin W.; Gelfand, Alan E.] Duke Univ, Dept Stat Sci, Box 90251, Durham, NC 27708 USA. [Schliep, Erin M.] Univ Missouri, Dept Stat, Columbia, MO 65211 USA. [Holland, David M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Rundel, CW (reprint author), Duke Univ, Dept Stat Sci, Box 90251, Durham, NC 27708 USA. EM rundel@gmail.com FU U.S. EPA's Office of Research and Development using EPA [EP-13-D-000089, EP-13-D-000257] FX The work of the first two authors was supported in part by funding through the U.S. EPA's Office of Research and Development using EPA contracts EP-13-D-000089 and EP-13-D-000257. The authors thank K. Wyat Appel of the National Exposure Research Laboratory/Atmospheric Modeling and Analysis Division (US EPA) for providing the CMAQ output and speciated monitoring data used in this analysis. NR 21 TC 0 Z9 0 U1 4 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1180-4009 EI 1099-095X J9 ENVIRONMETRICS JI Environmetrics PD DEC PY 2015 VL 26 IS 8 BP 515 EP 525 DI 10.1002/env.2369 PG 11 WC Environmental Sciences; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Environmental Sciences & Ecology; Mathematics GA DB3WD UT WOS:000368442900001 ER PT J AU Paranjpye, RN Nilsson, WB Liermann, M Hilborn, ED George, BJ Li, QL Bill, BD Trainer, VL Strom, MS Sandifer, PA AF Paranjpye, Rohinee N. Nilsson, William B. Liermann, Martin Hilborn, Elizabeth D. George, Barbara J. Li, Quanlin Bill, Brian D. Trainer, Vera L. Strom, Mark S. Sandifer, Paul A. TI Environmental influences on the seasonal distribution of Vibrio parahaemolyticus in the Pacific Northwest of the USA SO FEMS MICROBIOLOGY ECOLOGY LA English DT Article DE pathogens; Vibrio; HABS; microbial ecology ID POTENTIALLY PATHOGENIC VIBRIO; HARMFUL ALGAL BLOOMS; GULF-OF-MEXICO; WASHINGTON-STATE; WEST-COAST; AQUATIC ENVIRONMENT; UNITED-STATES; ADRIATIC SEA; CHOLERAE O1; DEPENDENT-VARIABLES AB Populations of Vibrio parahaemolyticus in the environment can be influenced by numerous factors. We assessed the correlation of total (tl+) and potentially virulent (tdh+) V. parahaemolyticus in water with three harmful algal bloom (HAB) genera (Pseudo-nitzschia, Alexandrium and Dinophysis), the abundance of diatoms and dinoflagellates, chlorophyll-a and temperature, salinity and macronutrients at five sites in Washington State from 2008-2009. The variability in V. parahaemolyticus density was explained predominantly by strong seasonal trends where maximum densities occurred in June, 2 months prior to the highest seasonal water temperature. In spite of large geographic differences in temperature, salinity and nutrients, there was little evidence of corresponding differences in V. parahaemolyticus density. In addition, there was no evident relationship between V. parahaemolyticus and indices of HAB genera, perhaps due to a lack of significant HAB events during the sampling period. The only nutrient significantly associated with V. parahaemolyticus density after accounting for the seasonal trend was silicate. This negative relationship may be caused by a shift in cell wall structure for some diatom species to a chitinous substrate preferred by V. parahaemolyticus. Results from our study differ from those in other regions corroborating previous findings that environmental factors that trigger vibrio and HAB events may differ depending on geographic locations. Therefore caution should be used when applying results from one region to another. C1 [Paranjpye, Rohinee N.; Nilsson, William B.; Liermann, Martin; Bill, Brian D.; Trainer, Vera L.; Strom, Mark S.] NOAA, Northwest Fisheries Sci Ctr, Natl Marine Fisheries Serv, 2725 Montlake Blvd E, Seattle, WA 98112 USA. [Hilborn, Elizabeth D.; George, Barbara J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Res Triangle Pk, NC 27709 USA. [Li, Quanlin] Cedars Sinai Med Ctr, Biostat & Bioinformat Res Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA. [Sandifer, Paul A.] NOAA, Hollings Marine Lab, Natl Ocean Serv, Charleston, SC 29412 USA. RP Paranjpye, RN (reprint author), NOAA, Northwest Fisheries Sci Ctr, Natl Marine Fisheries Serv, 2725 Montlake Blvd E, Seattle, WA 98112 USA. EM rohinee.paranjpye@noaa.gov RI Li, Quanlin/H-2358-2015 OI Li, Quanlin/0000-0002-3876-0617 FU Interagency Agreement [DW-13-92270801-1]; US EPA; NOAA Oceans and Human Health Initiative through an internal grant; Northwest Fisheries Science Center (NWFSC) FX This research was supported by Interagency Agreement DW-13-92270801-1 between the US EPA and NOAA and by the NOAA Oceans and Human Health Initiative through an internal grant to the West Coast Center for Oceans and Human Health at the Northwest Fisheries Science Center (NWFSC). The authors thank Dr Steve Jordan, USEPA, for assistance throughout the project and Dr Richard Spinrad, NOAA, for special assistance at the initiation of the project. Thanks to Cassandra Kamischke for phytoplankton analysis and Stephanie Moore for helpful discussions. Thanks also to Soundtoxins. org participants, Teri King (Washington Sea Grant, North Bay, WA), Lohna O'Rourke (Jamestown S'Klallam Tribe, Sequim Bay, WA), Taylor Shellfish (Dabob Bay, WA), Coast Seafoods (Quilcene Bay WA) and Ewann Berntson (NWFSC-Manchester) for help with sample collection. The views expressed in this manuscript are those of the individual authors and do not necessarily reflect the views and policies of the US Environmental Protection Agency or NOAA Fisheries. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 79 TC 1 Z9 1 U1 3 U2 14 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0168-6496 EI 1574-6941 J9 FEMS MICROBIOL ECOL JI FEMS Microbiol. Ecol. PD DEC PY 2015 VL 91 IS 12 DI 10.1093/femsec/fiv121 PG 12 WC Microbiology SC Microbiology GA DB3SA UT WOS:000368430600001 ER PT J AU Bellamy, M Puskin, J Hertel, N Eckerman, K AF Bellamy, M. Puskin, J. Hertel, N. Eckerman, K. TI An empirical method for deriving RBE values associated with electrons, photons and radionuclides SO RADIATION PROTECTION DOSIMETRY LA English DT Article ID TRACK STRUCTURE-ANALYSIS; LOW-ENERGY ELECTRONS; MAMMOGRAPHY X-RAYS; GAMMA-RAYS; NEOPLASTIC TRANSFORMATION; BIOLOGICAL EFFECTIVENESS; CHROMOSOME-ABERRATIONS; HUMAN-LYMPHOCYTES; LIQUID WATER; RADIATION AB There is substantial evidence to justify using relative biological effectiveness (RBE) values of > 1 for low-energy electrons and photons. But, in the field of radiation protection, radiation associated with low linear energy transfer has been assigned a radiation weighting factor w(R) of 1. This value may be suitable for radiation protection but, for risk considerations, it is important to evaluate the potential elevated biological effectiveness of radiation to improve the quality of risk estimates. RBE values between 2 and 3 for tritium are implied by several experimental measurements. Additionally, elevated RBE values have been found for other similar low-energy radiation sources. In this work, RBE values are derived for electrons based upon the fractional deposition of absorbed dose of energies less than a few kiloelectron volts. Using this empirical method, RBE values were also derived for monoenergetic photons and 1070 radionuclides from ICRP Publication 107 for which photons and electrons are the primary emissions. C1 [Bellamy, M.; Hertel, N.; Eckerman, K.] Oak Ridge Natl Lab, Ctr Radiat Protect Knowledge, POB 2008, Oak Ridge, TN 37831 USA. [Puskin, J.] EPA, Ctr Sci & Technol, Radiat Protect Div, ORIA 6608J, Washington, DC 20460 USA. RP Bellamy, M (reprint author), Oak Ridge Natl Lab, Ctr Radiat Protect Knowledge, POB 2008, Oak Ridge, TN 37831 USA. EM bellamymb@ornl.gov FU U.S. Environmental Protection Agency Office of Air and Radiation FX This work was supported by the U.S. Environmental Protection Agency Office of Air and Radiation and was prepared by Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Department of Energy. NR 38 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0144-8420 EI 1742-3406 J9 RADIAT PROT DOSIM JI Radiat. Prot. Dosim. PD DEC PY 2015 VL 167 IS 4 BP 664 EP 670 DI 10.1093/rpd/ncu358 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA DB3IY UT WOS:000368405600034 PM 25636403 ER PT J AU Logue, JM Sherman, MH Lunden, MM Klepeis, NE Williams, R Croghan, C Singer, BC AF Logue, J. M. Sherman, M. H. Lunden, M. M. Klepeis, N. E. Williams, R. Croghan, C. Singer, B. C. TI Development and assessment of a physics-based simulation model to investigate residential PM2.5 infiltration across the US housing stock SO BUILDING AND ENVIRONMENT LA English DT Article DE PM2.5; Indoor; Infiltration; Simulation; Residential ID FINE PARTICULATE MATTER; AIR EXCHANGE-RATES; INDOOR ENVIRONMENT; ASTHMATIC-CHILDREN; OUTDOOR SOURCES; HUMAN EXPOSURE; PARTICLES; POLLUTION; DEARS; DISTRIBUTIONS AB The Lawrence Berkeley National Laboratory Population Impact Assessment Modeling Framework (PIAMF) was expanded to enable determination of indoor PM2.5 concentrations and exposures in a set of 50,000 homes representing the US housing stock. A mass-balance model is used to calculate time-dependent pollutant concentrations within each home. The model includes size- and species-dependent removal mechanisms. The particle model was applied to the housing samples of the Relationship of Indoor, Outdoor, and Personal Air (RIOPA) and The Detroit Exposure and Aerosol Research Study (DEARS) studies to compare model- and measurement-based estimates of indoor PM2.5 of outdoor origin. Model-derived distributions of infiltration factors (ratio of indoor PM2.5 of outdoor origin to outdoor PM2.5) are compared to measurement-based distributions obtained in studies conducted in 11 US cities. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Logue, J. M.; Sherman, M. H.; Singer, B. C.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Energy Technol Area, Berkeley, CA 94720 USA. [Lunden, M. M.] Aclima Inc, San Francisco, CA USA. [Klepeis, N. E.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. [Klepeis, N. E.] San Diego State Univ, San Diego State Univ Res Fdn, Grad Sch Publ Hlth, Ctr Behav Epidemiol & Community Hlth C BEACH, San Diego, CA 92182 USA. [Williams, R.; Croghan, C.] US EPA, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA. RP Logue, JM (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Energy Technol Area, Berkeley, CA 94720 USA. EM jmlogue@lbl.gov FU U.S. Dept. of Energy Building Technologies Program, Office of Energy Efficiency and Renewable Energy under DOE [DE-AC02-05CH11231]; U.S. Dept. of Housing and Urban Development Office of Healthy Homes and Lead Hazard Control [I-PHI-01070]; U.S. Environmental Protection Agency [DW-89-9232201-7] FX Funding was provided by the U.S. Dept. of Energy Building Technologies Program, Office of Energy Efficiency and Renewable Energy under DOE Contract No. DE-AC02-05CH11231; by the U.S. Dept. of Housing and Urban Development Office of Healthy Homes and Lead Hazard Control through Interagency Agreement I-PHI-01070, and by the U.S. Environmental Protection Agency through Interagency Agreement DW-89-9232201-7. We would like to thank the Human Exposure and Atmospheric Sciences Division of the US Environmental Protection Agency for sharing data from the Detroit Exposure and Aerosol Research Study. We would also like to thank the University of Medicine and Dentistry of New Jersey, Rutgers University, the Health Effects Institute, Mickey Leland National Urban Air Toxics Research Center, and Atmospheric and Environmental Research for compiling and maintain an online database of measurement from the Relationships of Indoor, Outdoor, and Personal Air database. We would also like to thank the MESA AIR research group for providing data from their measurement studies. The United States Environmental Protection Agency through its Office of Research and Development has provided administrative review of this article and approved for publication. NR 48 TC 2 Z9 2 U1 6 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-1323 EI 1873-684X J9 BUILD ENVIRON JI Build. Environ. PD DEC PY 2015 VL 94 BP 21 EP 32 DI 10.1016/j.buildenv.2015.06.032 PN 1 PG 12 WC Construction & Building Technology; Engineering, Environmental; Engineering, Civil SC Construction & Building Technology; Engineering GA DA4GX UT WOS:000367759300003 ER PT J AU Beck, MW Hagy, JD AF Beck, Marcus W. Hagy, James D., III TI Adaptation of a Weighted Regression Approach to Evaluate Water Quality Trends in an Estuary SO ENVIRONMENTAL MODELING & ASSESSMENT LA English DT Article DE Trend analysis; Weighted regression; Estuary; Chlorophyll; Salinity; Tampa Bay ID QUANTILE REGRESSION; CHESAPEAKE BAY; PHYTOPLANKTON BIOMASS; TAMPA BAY; EUTROPHICATION; FLORIDA; MODEL; RIVER; REDUCTIONS; ECOSYSTEMS AB To improve the description of long-term changes in water quality, a weighted regression approach developed to describe trends in pollutant transport in rivers was adapted to analyze a long-term water quality dataset from Tampa Bay, Florida. The weighted regression approach allows for changes in the relationships between water quality and explanatory variables by using dynamic model parameters and can more clearly resolve the effects of both natural and anthropogenic drivers of ecosystem response. The model resolved changes in chlorophyll-a (chl-a) from 1974 to 2012 at seasonal and multi-annual time scales while considering variation associated with changes in freshwater influence. Separate models were developed for each of the four Bay segments to evaluate spatial differences in patterns of long-term change. Observed trends reflected the known decrease in nitrogen loading to Tampa Bay since the 1970s. Although median chl-a has remained constant in recent decades, model predictions indicated that variation has increased for upper Bay segments and that low biomass events in the lower Bay occur less often. Dynamic relationships between chl-a and freshwater inputs were observed from the model predictions and suggested changes in drivers of primary production across the time series. Results from our analyses have allowed additional insight into water quality changes in Tampa Bay that has not been possible with traditional modeling approaches. The approach could easily be applied to other systems with long-term datasets. C1 [Beck, Marcus W.] US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Hagy, James D., III] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Beck, MW (reprint author), US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM beck.marcus@epa.gov; hagy.jim@epa.gov NR 44 TC 2 Z9 2 U1 2 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1420-2026 EI 1573-2967 J9 ENVIRON MODEL ASSESS JI Environ. Model. Assess. PD DEC PY 2015 VL 20 IS 6 BP 637 EP 655 DI 10.1007/s10666-015-9452-8 PG 19 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA5YW UT WOS:000367879600006 ER PT J AU Pleil, JD Angrish, MM Madden, MC AF Pleil, Joachim D. Angrish, Michelle M. Madden, Michael C. TI Immunochemistry for high-throughput screening of human exhaled breath condensate (EBC) media: implementation of automated quanterix SIMOA instrumentation SO JOURNAL OF BREATH RESEARCH LA English DT Article DE exhaled breath condensate; immunochemistry; cytokines; inflammation ID RISK-ASSESSMENT; IN-VITRO; ENVIRONMENTAL-HEALTH; BIOMARKERS; EXPOSURE; SUSTAINABILITY; TOXICOLOGY; CYTOKINES; FRAMEWORK; EXPOSOME AB Immunochemistry is an important clinical tool for indicating biological pathways leading towards disease. Standard enzyme-linked immunosorbent assays (ELISA) are labor intensive and lack sensitivity at low-level concentrations. Here we report on emerging technology implementing fully-automated ELISA capable of molecular level detection and describe application to exhaled breath condensate (EBC) samples. The Quanterix SIMOA HD-1 analyzer was evaluated for analytical performance for inflammatory cytokines (IL-6, TNF-alpha, IL-1 beta and IL-8). The system was challenged with human EBC representing the most dilute and analytically difficult of the biological media. Calibrations from synthetic samples and spiked EBC showed excellent linearity at trace levels (r(2) > 0.99). Sensitivities varied by analyte, but were robust from similar to 0.006 (IL-6) to similar to 0.01 (TNF-alpha) pg ml(-1). All analytes demonstrated response suppression when diluted with deionized water and so assay buffer diluent was found to be a better choice. Analytical runs required similar to 45 min setup time for loading samples, reagents, calibrants, etc., after which the instrument performs without further intervention for up to 288 separate samples. Currently, available kits are limited to single-plex analyses and so sample volumes require adjustments. Sample dilutions should be made with assay diluent to avoid response suppression. Automation performs seamlessly and data are automatically analyzed and reported in spreadsheet format. The internal 5-parameter logistic (pl) calibration model should be supplemented with a linear regression spline at the very lowest analyte levels, (<1.3 pg ml(-1)). The implementation of the automated Quanterix platform was successfully demonstrated using EBC, which poses the greatest challenge to ELISA due to limited sample volumes and low protein levels. C1 [Pleil, Joachim D.] US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. [Angrish, Michelle M.] US EPA, Integrated Syst Toxicol Div, NHEERL ORD, Res Triangle Pk, NC 27711 USA. [Madden, Michael C.] US EPA, Environm Publ Hlth Div, NHEERL ORD, Chapel Hill, NC USA. RP Pleil, JD (reprint author), US EPA, Human Exposure & Atmospher Sci Div, NERL ORD, Res Triangle Pk, NC 27711 USA. EM Pleil.joachim@epa.gov NR 36 TC 3 Z9 3 U1 2 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD DEC PY 2015 VL 9 IS 4 AR 047108 DI 10.1088/1752-7155/9/4/047108 PG 7 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA DA6SR UT WOS:000367936100011 PM 26658359 ER PT J AU Ducey, TF Novak, JM Johnson, MG AF Ducey, Thomas F. Novak, Jeffrey M. Johnson, Mark G. TI Effects of Biochar Blends on Microbial Community Composition in Two Coastal Plain Soils SO AGRICULTURE-BASEL LA English DT Article DE biochar; soil microbiology; southeastern United States ID FATTY-ACID PROFILES; PHOSPHORUS LIMITATION; SWITCHGRASS BIOCHAR; TEMPERATE SOILS; PLANT-GROWTH; WHEAT CROP; NITROGEN; MANAGEMENT; BIOMASS; FIELD AB The amendment of soil with biochar has been demonstrated to have an effect not only on the soil physicochemical properties, but also on soil microbial community composition and activity. Previous reports have demonstrated significant impacts on soil microbial community structure. These impacts are modulated not only by the biochar composition, but also on the soil's physicochemical characteristics. This indicates that soil characteristics must be considered prior to biochar amendment. A significant portion of the soils of the southeastern coastal plain are severely degraded and, therefore, candidates for biochar amendment to strengthen soil fertility. In this study we focused on two common soil series in the southeastern coastal plain, utilizing feedstocks endemic to the area. We chose feedstocks in four ratios (100% pine chip; 80:20 mixture of pine chip to poultry litter; 50:50 mixture of pine chip to poultry litter; 100% poultry litter) prior to pyrolysis and soil amendment as a biochar product. Soil was analyzed for bioavailable nutrients via Mehlich-1 extractions, as well as microbial community composition using phospholipid fatty acid analysis (PLFA). Our results demonstrated significant shifts in microbial community composition in response to biochar amendment, the effects of which were greatest with 100% poultry litter biochar. Strong relationships between PLFAs and several Mehlich-1 extractable nutrients (Al, Cu, Fe, and P) were observed. C1 [Ducey, Thomas F.; Novak, Jeffrey M.] USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Johnson, Mark G.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. RP Ducey, TF (reprint author), USDA ARS, Coastal Plains Soil Water & Plant Res Ctr, 2611 West Lucas St, Florence, SC 29501 USA. EM thomas.ducey@ars.usda.gov; jeff.novak@ars.usda.gov; johnson.mark@epa.gov NR 40 TC 2 Z9 2 U1 7 U2 8 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2077-0472 J9 AGRICULTURE-BASEL JI Agriculture-Basel PD DEC PY 2015 VL 5 IS 4 BP 1060 EP 1075 DI 10.3390/agriculture5041060 PG 16 WC Agronomy SC Agriculture GA DA2CM UT WOS:000367602900009 ER PT J AU Liu, XY Mason, MA Guo, ZS Krebs, KA Roache, NF AF Liu, Xiaoyu Mason, Mark A. Guo, Zhishi Krebs, Kenneth A. Roache, Nancy F. TI Source emission and model evaluation of formaldehyde from composite and solid wood furniture in a full-scale chamber SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Formaldehyde; Emissions from furnishings; Source emission model; Full-scale chamber; First-order decay model; Power-law decay model ID VOLATILE ORGANIC-COMPOUNDS; BUILDING-MATERIALS; VOC EMISSIONS; DIFFUSION; COEFFICIENTS AB This paper describes the measurement and model evaluation of formaldehyde source emissions from composite and solid wood furniture in a full-scale chamber at different ventilation rates for up to 4000 h using AS'TM D 6670-01 (2007). Tests were performed on four types of furniture constructed of different materials and from different manufacturers. The data were used to evaluate two empirical emission models, i.e., a first-order and power-law decay model. The experimental results showed that some furniture tested in this study, made only of solid wood and with less surface area, had low formaldehyde source emissions. The effect of ventilation rate on formaldehyde emissions was also examined. Model simulation results indicated that the power-law decay model showed better agreement than the first-order decay model for the data collected from the tests, especially for long-term emissions. This research was limited to a laboratory study with only four types of furniture products tested. It was not intended to comprehensively test or compare the large number of furniture products available in the market place. Therefore, care should be taken when applying the test results to real-world scenarios. Also, it was beyond the scope of this study to link the emissions to human exposure and potential health risks. Published by Elsevier Ltd. C1 [Liu, Xiaoyu; Mason, Mark A.; Guo, Zhishi; Krebs, Kenneth A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Roache, Nancy F.] Arcadis, Durham, NC 27713 USA. RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM liu.xiaoyu@epa.gov NR 34 TC 1 Z9 1 U1 4 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2015 VL 122 BP 561 EP 568 DI 10.1016/j.atmosenv.2015.09.062 PG 8 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ9JJ UT WOS:000367413600058 ER PT J AU Kaduwela, A Luecken, D Carter, W Derwent, R AF Kaduwela, Ajith Luecken, Deborah Carter, William Derwent, Richard TI New directions: Atmospheric chemical mechanisms for the future SO ATMOSPHERIC ENVIRONMENT LA English DT Editorial Material C1 [Kaduwela, Ajith] Calif Air Resources Board, Air Qual Planning & Sci Div, Sacramento, CA USA. [Kaduwela, Ajith] Univ Calif Davis, Air Qual Res Ctr, Sacramento, CA 95817 USA. [Luecken, Deborah] US EPA, Res Triangle Pk, NC 27711 USA. [Carter, William] Univ Calif Riverside, Coll Engn, Ctr Environm Res & Technol, Riverside, CA 92521 USA. [Derwent, Richard] Rdscientific, Newbury, Berks, England. RP Derwent, R (reprint author), Rdscientific, Newbury, Berks, England. EM r.derwent@btopenworld.com OI Carter, William/0000-0003-1682-8219; Derwent, Richard/0000-0003-4498-645X NR 5 TC 1 Z9 1 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2015 VL 122 BP 609 EP 610 DI 10.1016/j.atmosenv.2015.10.031 PG 2 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ9JJ UT WOS:000367413600064 ER PT J AU Bjorkland, R Dunn, DC McClure, M Jannot, J Bellman, MA Gleason, M Schiffers, K AF Bjorkland, Rhema Dunn, Daniel C. McClure, Michelle Jannot, Jason Bellman, Marlene A. Gleason, Mary Schiffers, Katja TI Spatiotemporal patterns of rockfish bycatch in US west coast groundfish fisheries: opportunities for reducing incidental catch of depleted species SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID AIC MODEL SELECTION; BRITISH-COLUMBIA; POINT-PROCESSES; TRAWL FISHERY; MANAGEMENT; CALIFORNIA; INFERENCE; QUOTAS AB Spatial and temporal management measures to reduce nontarget catch are important strategies for rebuilding overfished rockfish (Sebastes spp.) populations in the Northeast Pacific. We describe efforts to support reducing rockfish bycatch in central California trawl fisheries by testing the efficacy of move-on rules on catch data from 2002 to 2010. Move-on rules are regulations or guidelines that trigger the temporary closure of a fishery in a targeted area when a bycatch threshold is reached, without the closure of the entire fishery. Move-on rules based on spatiotemporal autocorrelation (clustering) were effective in reducing bycatch with modest impact on target catch, removing between 35% and 77% of future hauls with bycatch within a specified distance and time of a bycatch-containing haul, while foregoing target catch by an average of 12%. The spatial and temporal peak clustering scales show correlation with the level of schooling behavior by each species; however, the efficiency of the rules measured either in reduction in bycatch hauls or diminished target catch was not strongly affected by those aggregation behaviors. Our analysis provides information for fishers, such as those in the California Risk Pool, in the continuing development of responses that are more refined in both scale and impact. C1 [Bjorkland, Rhema; McClure, Michelle; Jannot, Jason; Bellman, Marlene A.] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Fisheries Resource Assessment & Monitoring Div, Seattle, WA 98112 USA. [Dunn, Daniel C.] Duke Univ, Nicholas Sch Environm, Marine Lab, Marine Geospatial Ecol Lab, Beaufort, NC 28516 USA. [Gleason, Mary] Nature Conservancy, Monterey, CA 93940 USA. [Schiffers, Katja] Univ Grenoble 1, Lab Ecol Alpine, Evolut Modeling & Analyzing Biodivers Grp, UMR CNRS 5553, Grenoble 9, France. RP Bjorkland, R (reprint author), US EPA, Washington, DC 20460 USA. EM rhemaker@hotmail.com RI McClure, Michelle/O-7853-2015; OI McClure, Michelle/0000-0003-4791-8719; Dunn, Daniel/0000-0001-8932-0681 FU National Research Council's Research Associate Program; NF-UBC Nereus Program FX We thank the anonymous reviewers whose insights and comments improved this manuscript. R. Bjorkland was supported by the National Research Council's Research Associate Program. D.C. Dunn was supported by the NF-UBC Nereus Program. NR 41 TC 1 Z9 1 U1 5 U2 8 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0706-652X EI 1205-7533 J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD DEC PY 2015 VL 72 IS 12 BP 1835 EP 1846 DI 10.1139/cjfas-2014-0242 PG 12 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA DA1LF UT WOS:000367556600006 ER PT J AU Berggren, E Amcoff, P Benigni, R Blackburn, K Carney, E Cronin, M Deluyker, H Gautier, F Judson, RS Kass, GEN Keller, D Knight, D Lilienblum, W Mahony, C Rusyn, I Schultz, T Schwarz, M Schuurmann, G White, A Burton, J Lostia, AM Munn, S Worth, A AF Berggren, Elisabet Amcoff, Patric Benigni, Romualdo Blackburn, Karen Carney, Edward Cronin, Mark Deluyker, Hubert Gautier, Francoise Judson, Richard S. Kass, Georges E. N. Keller, Detlef Knight, Derek Lilienblum, Werner Mahony, Catherine Rusyn, Ivan Schultz, Terry Schwarz, Michael Schueuermann, Gerrit White, Andrew Burton, Julien Lostia, Alfonso M. Munn, Sharon Worth, Andrew TI Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID RISK-ASSESSMENT; IN-VITRO; FRAMEWORK; TOXICITY; HAZARD; UNCERTAINTY; INTEGRATION; REACTIVITY; TOXICOLOGY; RELEVANCE AB BACKGROUND: Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on alternative testing, co-funded by the European Commission and Cosmetics Europe. This review is based on the discussion and outcome of a workshop organized on initiative of the SEURAT-1 consortium joined by a group of international experts with complementary knowledge to further develop traditional read-across and include new approach data. OBJECTIVES: The aim of the suggested strategy for chemical read-across is to show how a traditional read-across based on structural similarities between source and target substance can be strengthened with additional evidence from new approach data-for example, information from in-vitro molecular screening, "-omics" assays and computational models-to reach regulatory acceptance. METHODS: We identified four read-across scenarios that cover typical human health assessment situations. For each such decision context, we suggested several chemical groups as examples to prove when read-across between group members is possible, considering both chemical and biological similarities. CONCLUSIONS: We agreed to carry out the complete read-across exercise for at least one chemical category per read-across scenario in the context of SEURAT-1, and the results of this exercise will be completed and presented by the end of the research initiative in December 2015. C1 [Berggren, Elisabet; Burton, Julien; Lostia, Alfonso M.; Munn, Sharon; Worth, Andrew] European Commiss, Joint Res Ctr, I-21027 Ispra, Italy. [Amcoff, Patric] Cosmet Europe, Brussels, Belgium. [Benigni, Romualdo] OECD, Paris, France. [Blackburn, Karen] Procter & Gamble, Cincinnati, OH USA. [Carney, Edward] Dow Chem Co USA, Midland, MI 48674 USA. [Cronin, Mark] Liverpool John Moores Univ, Liverpool L3 5UX, Merseyside, England. [Deluyker, Hubert; Kass, Georges E. N.] EFSA, Parma, Italy. [Gautier, Francoise] L Oreal, Asnieres, France. [Judson, Richard S.] US EPA, Washington, DC 20460 USA. [Keller, Detlef] Henkel AG & Co, Dusseldorf, Germany. [Knight, Derek] ECHA European Chem Agcy, Helsinki, Finland. [Lilienblum, Werner] SCCS, Luxembourg, Luxembourg. [Mahony, Catherine] Procter & Gamble, Egham, Surrey, England. [Rusyn, Ivan] Texas A&M Univ, College Stn, TX USA. [Schultz, Terry] Univ Tennessee, Knoxville, TN USA. [Schwarz, Michael] Univ Tubingen, Tubingen, Germany. [Schueuermann, Gerrit] Helmholtz Ctr Environm Res, Leipzig, Germany. [Schueuermann, Gerrit] Tech Univ Bergakademie Freiberg, Inst Organ Chem, Freiberg, Germany. [White, Andrew] Unilever PLC, Milton Keynes, Bucks, England. RP Berggren, E (reprint author), European Commiss, Joint Res Ctr, Syst Toxicol IHCP, Via Fermi 2749, I-21027 Ispra, VA, Italy. EM elisabet.berggren@ec.europa.eu RI Rusyn, Ivan/S-2426-2016; Schuurmann, Gerrit/E-7962-2017 OI Schuurmann, Gerrit/0000-0002-3789-1703 FU European Community's Seventh Framework Programme (FP7) [267044]; Cosmetics Europe FX This work, which was carried out under the SEURAT-1 research initiative, has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement 267044, and has received financing from Cosmetics Europe. NR 63 TC 9 Z9 9 U1 5 U2 25 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD DEC PY 2015 VL 123 IS 12 BP 1232 EP 1240 DI 10.1289/ehp.1409342 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1WS UT WOS:000367587000010 PM 25956009 ER PT J AU Chiu, WA Slob, W AF Chiu, Weihsueh A. Slob, Wout TI A Unified Probabilistic Framework for Dose-Response Assessment of Human Health Effects SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID RISK-ASSESSMENT; UNCERTAINTY; EXTRAPOLATION; DISTRIBUTIONS; VARIABILITY; CHEMICALS; SCIENCE; HAZARD; MOUSE; NOAEL AB BACKGROUND: When chemical health hazards have been identified, probabilistic dose-response assessment ("hazard characterization") quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches differ for different types of endpoints or modes-of-action, lacking a unifying framework. OBJECTIVES: We developed a unified framework for probabilistic dose-response assessment. METHODS: We established a framework based on four principles: a) individual and population dose responses are distinct; b) dose-response relationships for all (including quantal) endpoints can be recast as relating to an underlying continuous measure of response at the individual level; c) for effects relevant to humans, "effect metrics" can be specified to define "toxicologically equivalent" sizes for this underlying individual response; and d) dose-response assessment requires making adjustments and accounting for uncertainty and variability. We then derived a step-by-step probabilistic approach for dose-response assessment of animal toxicology data similar to how nonprobabilistic reference doses are derived, illustrating the approach with example non-cancer and cancer datasets. RESULTS: Probabilistically derived exposure limits are based on estimating a "target human dose" (HDMI), which requires risk management-informed choices for the magnitude (M) of individual effect being protected against, the remaining incidence (I) of individuals with effects >= M in the population, and the percent confidence. In the example datasets, probabilistically derived 90% confidence intervals for HDMI values span a 40- to 60-fold range, where I = 1% of the population experiences >= M = 1%-10% effect sizes. CONCLUSIONS: Although some implementation challenges remain, this unified probabilistic framework can provide substantially more complete and transparent characterization of chemical hazards and support better-informed risk management decisions. C1 [Chiu, Weihsueh A.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. [Slob, Wout] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. RP Chiu, WA (reprint author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, VMA Bldg,Room 107,4458 TAMU, College Stn, TX 77843 USA. EM wchiu@cvm.tamu.edu NR 52 TC 1 Z9 1 U1 3 U2 7 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD DEC PY 2015 VL 123 IS 12 BP 1241 EP 1254 DI 10.1289/ehp.1409385 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1WS UT WOS:000367587000011 PM 26006063 ER PT J AU Chang, SY Vizuete, W Breen, M Isakov, V Arunachalam, S AF Chang, Shih Ying Vizuete, William Breen, Michael Isakov, Vlad Arunachalam, Saravanan TI Comparison of Highly Resolved Model-Based Exposure Metrics for Traffic-Related Air Pollutants to Support Environmental Health Studies SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article; Proceedings Paper CT Scientific Symposium Small Solution for Big Water-Related Problems Innovative Microarrays and Small Sensors to Cope with Water Quality and Food Security CY OCT 26-28, 2014 CL Rome, ITALY DE traffic related air pollution; exposure error; air quality model; space-time kriging; exposure metric; dispersion model ID NEAR-ROAD EXPOSURES; UNITED-STATES; POLLUTION EXPOSURE; ASTHMATIC-CHILDREN; PARTICULATE MATTER; MEASUREMENT ERROR; EXCHANGE-RATES; NORTH-CAROLINA; LOS-ANGELES; PM2.5 AB Human exposure to air pollution in many studies is represented by ambient concentrations from space-time kriging of observed values. Space-time kriging techniques based on a limited number of ambient monitors may fail to capture the concentration from local sources. Further, because people spend more time indoors, using ambient concentration to represent exposure may cause error. To quantify the associated exposure error, we computed a series of six different hourly-based exposure metrics at 16,095 Census blocks of three Counties in North Carolina for CO, NOx, PM2.5, and elemental carbon (EC) during 2012. These metrics include ambient background concentration from space-time ordinary kriging (STOK), ambient on-road concentration from the Research LINE source dispersion model (R-LINE), a hybrid concentration combining STOK and R-LINE, and their associated indoor concentrations from an indoor infiltration mass balance model. Using a hybrid-based indoor concentration as the standard, the comparison showed that outdoor STOK metrics yielded large error at both population (67% to 93%) and individual level (average bias between -10% to 95%). For pollutants with significant contribution from on-road emission (EC and NOx), the on-road based indoor metric performs the best at the population level (error less than 52%). At the individual level, however, the STOK-based indoor concentration performs the best (average bias below 30%). For PM2.5, due to the relatively low contribution from on-road emission (7%), STOK-based indoor metric performs the best at both population (error below 40%) and individual level (error below 25%). The results of the study will help future epidemiology studies to select appropriate exposure metric and reduce potential bias in exposure characterization. C1 [Chang, Shih Ying; Arunachalam, Saravanan] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA. [Chang, Shih Ying; Vizuete, William] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Breen, Michael; Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM changsy5@live.unc.edu; airquality@unc.edu; breen.michael@epa.gov; Isakov.vlad@epa.gov; sarav@email.unc.edu OI vizuete, william/0000-0002-1399-2948 FU U.S. Environmental Protection Agency, through its Office of Research and Development [EP-D-12-044] FX The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded and collaborated in the research described here under Contract No. EP-D-12-044 to the University of North Carolina at Chapel Hill. This paper has been subjected to Agency review and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 48 TC 0 Z9 0 U1 5 U2 11 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD DEC PY 2015 VL 12 IS 12 BP 15605 EP 15625 DI 10.3390/ijerph121215007 PG 21 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DA1EL UT WOS:000367539000051 PM 26670242 ER PT J AU Baker, KR Emery, C Dolwick, P Yarwood, G AF Baker, Kirk R. Emery, Chris Dolwick, Pat Yarwood, Greg TI Photochemical grid model estimates of lateral boundary contributions to ozone and particulate matter across the continental United States SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Boundary contribution; Boundary inflow; Source apportionment; OSAT; RTRAC; PSAT ID RELEVANT BACKGROUND OZONE; SOURCE APPORTIONMENT; DRY DEPOSITION; IMPLEMENTATION AB Multiple approaches to characterize lateral boundary contributions to photochemical model predicted ozone (O-3) and particulate matter less than 2.5 microns in diameter (PM2.5) are available in the Comprehensive Air quality Model with extensions (CAMx). Here, three approaches are used for O-3: (1) a comprehensive source apportionment scheme for chemical boundary conditions and emissions (OSAT), (2) chemically reactive tracers (RTRAC), and (3) chemically inert tracers. Two approaches are used for PM2.5: (1) particulate source apportionment (PSAT) and (2) chemically inert tracers. The inert tracer approach resulted in higher O-3 lateral boundary contribution estimates because the method does not account for any O-3 destruction reactions. OSAT and RTRAC estimate generally similar monthly average contributions during the warmer months although RTRAC estimates higher urban area contribution during the cold months because this RTRAC implementation did not treat O-3 titration by NO. Accurate representation of lateral boundary O-3 impacts must include appropriate accounting for O-3 destruction reactions. OSAT and RTRAC were configured to estimate the contribution to modeled O-3 from each of the four lateral faces of the model domain. RTRAC was configured to further stratify the western and northern boundaries by groups of vertical layers. The RTRAC approach showed that the largest O-3 contributions to the continental U.S. are from the mid-troposphere, with less contribution from the upper troposphere/lower stratosphere. Inert tracers compared more closely to reactive tracers on average for PM2.5 compared to O-3. This close agreement for PM2.5 indicates most of the lateral boundary contribution is from PM2.5 rather than precursor inflow. A strong relationship exists between model predicted PM2.5 boundary contribution and model overestimates of nitrate and organic carbon at IMPROVE monitor locations suggesting global model estimates of these species were overestimated at some places and times. Published by Elsevier Ltd. C1 [Baker, Kirk R.; Dolwick, Pat] US EPA, Res Triangle Pk, NC 27711 USA. [Emery, Chris; Yarwood, Greg] Ramboll Environ, Novato, CA 94998 USA. RP Baker, KR (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM baker.kirk@epa.gov OI Dolwick, Patrick/0000-0002-9629-2786 NR 36 TC 2 Z9 2 U1 5 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2015 VL 123 BP 49 EP 62 DI 10.1016/j.atmosenv.2015.10.055 PN A PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DA0PC UT WOS:000367498600006 ER PT J AU Wang, JD Wang, SX Voorhees, AS Zhao, B Jang, C Jiang, JK Fu, JS Ding, D Zhu, Y Hao, JM AF Wang, Jiandong Wang, Shuxiao Voorhees, A. Scott Zhao, Bin Jang, Carey Jiang, Jingkun Fu, Joshua S. Ding, Dian Zhu, Yun Hao, Jiming TI Assessment of short-term PM2.5-related mortality due to different emission sources in the Yangtze River Delta, China SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE PM2.5; Mortality; Economic loss; Source apportionment; Yangtze River Delta ID PARTICULATE AIR-POLLUTION; HEALTH-BENEFITS; MATTER POLLUTION; COARSE PARTICLES; INDOOR EXPOSURE; GLOBAL BURDEN; URBAN AREAS; SHANGHAI; POLLUTANTS; QUALITY AB Air pollution is a major environmental risk to health. In this study, short-term premature mortality due to particulate matter equal to or less than 2.5 mu m in aerodynamic diameter (PM2.5) in the Yangtze River Delta (YRD) is estimated by using a PC-based human health benefits software. The economic loss is assessed by using the willingness to pay (WTP) method. The contributions of each region, sector and gaseous precursor are also determined by employing brute-force method. The results show that, in the YRD in 2010, the short-term premature deaths caused by PM2.5 are estimated to be 13,162 (95% confidence interval (CI): 10,761-15,554), while the economic loss is 22.1 (95% Cl: 18.1-26.1) billion Chinese Yuan. The industrial and residential sectors contributed the most, accounting for more than 50% of the total economic loss. Emissions of primary PM2.5 and NH3 are major contributors to the health-related loss in winter, while the contribution of gaseous precursors such as SO2 and NOx is higher than primary PM2.5 in summer. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wang, Jiandong; Wang, Shuxiao; Zhao, Bin; Jiang, Jingkun; Hao, Jiming] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. [Wang, Jiandong; Wang, Shuxiao; Zhao, Bin; Jiang, Jingkun; Hao, Jiming] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China. [Voorhees, A. Scott; Jang, Carey] US EPA, Res Triangle Pk, NC 27711 USA. [Fu, Joshua S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA. [Ding, Dian; Zhu, Yun] S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China. RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. EM shxwang@tsinghua.edu.cn RI wang, shuxiao/H-5990-2011; Wang, Jiandong/O-1863-2015 OI wang, shuxiao/0000-0001-9727-1963; Wang, Jiandong/0000-0003-3000-622X FU National Natural Science Foundation of China [21221004]; Chinese Academy of Sciences [XBD05020300]; MEP's special funds for Research on Public Welfares [201309009, 201409002]; Collaborative Innovation Center for Regional Environmental Quality, Tsinghua University FX This work was sponsored by National Natural Science Foundation of China (21221004), Strategic Priority Research Program of the Chinese Academy of Sciences (XBD05020300), and MEP's special funds for Research on Public Welfares (201309009, 201409002). The authors also appreciate the support from Collaborative Innovation Center for Regional Environmental Quality, Tsinghua University. NR 56 TC 7 Z9 9 U1 10 U2 41 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2015 VL 123 SI SI BP 440 EP 448 DI 10.1016/j.atmosenv.2015.05.060 PN B PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ9HN UT WOS:000367408800017 ER PT J AU Iyer, GC Edmonds, JA Fawcett, AA Hultman, NE Alsalam, J Asrar, GR Calvin, KV Clarke, LE Creason, J Jeong, M Kyle, P McFarland, J Mundra, A Patel, P Shi, WJ McJeon, HC AF Iyer, Gokul C. Edmonds, James A. Fawcett, Allen A. Hultman, Nathan E. Alsalam, Jameel Asrar, Ghassem R. Calvin, Katherine V. Clarke, Leon E. Creason, Jared Jeong, Minji Kyle, Page McFarland, James Mundra, Anupriya Patel, Pralit Shi, Wenjing McJeon, Haewon C. TI The contribution of Paris to limit global warming to 2 degrees C SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Article DE conference of Parties; climate change; mitigation; policy; integrated assessment model; INDC; energy ID CLIMATE-CHANGE MITIGATION; INTEGRATED ASSESSMENT; CO2 CONCENTRATIONS; CARBON CAPTURE; LAND-USE; ENERGY; TECHNOLOGIES; SCENARIOS; TRANSPORTATION; STABILIZATION AB The international community has set a goal to limit global warming to 2 degrees C. Limiting global warming to 2 degrees C is a challenging goal and will entail a dramatic transformation of the global energy system, largely complete by 2040. As part of the work toward this goal, countries have been submitting their Intended Nationally Determined Contributions (INDCs) to the United Nations Framework Convention on Climate Change, indicating their emissions reduction commitments through 2025 or 2030, in advance of the 21st Conference of the Parties (COP21) in Paris in December 2015. In this paper, we use the Global Change Assessment Model (GCAM) to analyze the near versus long-term energy and economic-cost implications of these INDCs. The INDCs imply near-term actions that reduce the level of mitigation needed in the post-2030 period, particularly when compared with an alternative path in which nations are unable to undertake emissions mitigation until after 2030. We find that the latter case could require up to 2300 GW of premature retirements of fossil fuel power plants and up to 2900 GW of additional low-carbon power capacity installations within a five-year period of 2031-2035. INDCs have the effect of reducing premature retirements and new-capacity installations after 2030 by 50% and 34%, respectively. However, if presently announced INDCs were strengthened to achieve greater near-term emissions mitigation, the 2031-2035 transformation could be tempered to require 84% fewer premature retirements of power generation capacity and 56% fewer new-capacity additions. Our results suggest that the INDCs delivered for COP21 in Paris will have important contributions in reducing the challenges of achieving the goal of limiting global warming to 2 degrees C. C1 [Iyer, Gokul C.; Edmonds, James A.; Asrar, Ghassem R.; Calvin, Katherine V.; Clarke, Leon E.; Jeong, Minji; Kyle, Page; Mundra, Anupriya; Patel, Pralit; Shi, Wenjing; McJeon, Haewon C.] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA. [Fawcett, Allen A.; Alsalam, Jameel; Creason, Jared; McFarland, James] US EPA, Washington, DC 20460 USA. [Hultman, Nathan E.] Univ Maryland, Sch Publ Policy, College Pk, MD 20742 USA. RP McJeon, HC (reprint author), Pacific NW Natl Lab, Joint Global Change Res Inst, 5825 Univ Res Court,Suite 3500, College Pk, MD 20740 USA. EM haewon.mcjeon@pnnl.gov FU U.S. Department of State [IAA 19318814Y0012]; U.S. Environmental Protection Agency [IAADW-8992406301]; William and Flora Hewlett Foundation FX Analysis of mitigation potential and levels of national mitigation action related to the conclusions of this paper was supported by the U.S. Department of State (IAA 19318814Y0012) and the U.S. Environmental Protection Agency (IAADW-8992406301). NEH was supported by the William and Flora Hewlett Foundation. The assessments of newly submitted INDCs are continuously updated at http://www.globalchange.umd.edu/. The views and opinions expressed in this paper are those of the authors alone and do not necessarily state or reflect those of the United States Government, the Department of State, or the Environmental Protection Agency, and no official endorsement should be inferred. NR 37 TC 6 Z9 6 U1 17 U2 66 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD DEC PY 2015 VL 10 IS 12 AR 125002 DI 10.1088/1748-9326/10/12/125002 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ7NO UT WOS:000367286300034 ER PT J AU Kelly, JR Yurista, P Starry, M Scharold, J Bartsch, W Cotter, A AF Kelly, John R. Yurista, Peder Starry, Matthew Scharold, Jill Bartsch, Will Cotter, Anne TI Exploration of spatial variability in nearshore water quality using the first Great Lakes National Coastal Condition Assessment survey SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Nearshore; Embayments; Assessment; Phosphorus; Watersheds; Great Lakes ID ENVIRONMENTAL INDICATORS; OFFSHORE WATERS; UNITED-STATES; ERIE; PHOSPHORUS; WETLANDS; CLASSIFICATION; RESOURCES; ECOSYSTEMS; MANAGEMENT AB A comprehensive approach to assess conditions in the Great Lakes nearshore has been lacking for decades. We conducted a pilot survey in Lake Erie (45 sites) in summer 2009. The US National Coastal Condition Assessment (NCCA) was then conducted across the Great Lakes in summer 2010. The NCCA survey design provided statistically based estimates with defined uncertainty bounds for a variety of ecological indicators. For example, water quality (WQ) was measured (233 sampled sites) in the US nearshore, a resource defined with criteria to include waters to 30 m depth and less than 5 km from shore. A sub-resource of the US nearshore (151 separate sample sites) was defined using geometric criteria along the shoreline to identify small to medium embayment areas. Statistical analyses showed that embayments had higher Total Phosphorus and were more turbid than the open nearshore. We explored spatial variability in WQ results (2009, 2010) through regression analyses at multiple scales (within and across lakes) for nearshore and embayment resources. Empirical modeling identified principal drivers of spatial variability as risk factors for enrichment: water column depth and a landscape disturbance metric representing agricultural intensity as an indicator of watershed nutrient loading. Eutrophic nearshore conditions occurred at the upper end of an associated landscape disturbance gradient across watersheds of the US basin, peaking in Lake Erie. Overall results were consistent with the principles of classical limnology theory and demonstrated that a statistical survey approach can contribute to Great Lakes nearshore assessment and research. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Kelly, John R.; Yurista, Peder; Scharold, Jill; Cotter, Anne] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Starry, Matthew] SRA Int, Fairfax, VA 22033 USA. [Bartsch, Will] Oak Ridge Inst Sci & Educ, Duluth, MN 55804 USA. RP Kelly, JR (reprint author), 904 Valley Dr, Duluth, MN 55804 USA. EM jackrussellkelly@gmail.com FU EPA's Office of Water; Great Lakes Restoration Initiative (GLRI) funds FX The US EPA Office of Water, staff from EPA Regions 2, 3, and 5 and the Great Lakes National Program Office (GLNPO), and from the 8 Great Lakes US States conducted the US National Coastal Condition Assessment (NCCA) in summer 2010 as part of a set of National Aquatic Resource Surveys. Funding to conduct the NCCA came from EPA's Office of Water who assists States in the conduct of National Aquatic Resource Surveys, and from enhancements supported by Great Lakes Restoration Initiative (GLRI) funds, thanks to the vision and determination of Gary Gulezian and Paul Horvatin. The development of this Great lakes coastal frame and survey design/analysis has been aided by a strong commitment to include the Great Lakes in the national assessment over almost a decade, of individuals in the EPA's Office of Research and Development (Tony Olsen and Tom Kinkaid, Western Ecology Division; John Macauley, Gulf Ecology Division; John Kiddon, Atlantic Ecology Division) and Office of Water (Barry Burgan and Greg Colianni). Others in EPA's Office of Water have been instrumental in supporting the Great Lakes development, including Sarah Lehmann, Treda Greyson-Smith, and at Region 5/GLNPO (Paul Horvatin, Mari Nord, Paul Bertram, Elizabeth Hinchey-Malloy). The survey design was done by Tony Olsen and Tom Kincaid, who each assisted with some statistical analyses. Numerous colleagues from the Mid-Continent Ecology Division assisted with fieldwork in 2009, including Jon Van Alstine, Tim Corry, Greg Peterson, Joel Hoffman, Mike Knuth, Sam Miller, David Miller, John Morrice, and summer students Andrew Just, Aisha Beaty, and Emily Bradshaw. We acknowledge especially Glenn Warren and Paul Horvatin (GLNPO) for providing time on the R/V Lake Guardian. Tom Hollenhorst of MED assisted with organizing the GLEI landscape stressor data sets. This manuscript was approved for submission by the US EPA. Thanks to David Bolgrien and JGLR anonymous reviewers for comments that helped clarify presentation. The views expressed in this article are those of the author and do not necessarily reflect the views or policies of the US Environment Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 90 TC 0 Z9 0 U1 3 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD DEC PY 2015 VL 41 IS 4 BP 1060 EP 1074 DI 10.1016/j.jglr.2015.09.007 PG 15 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CZ8OU UT WOS:000367359800011 ER PT J AU Trebitz, A Shepard, G Brady, V Schmude, K AF Trebitz, Anett Shepard, Gerald Brady, Valerie Schmude, Kurt TI The non-native faucet snail (Bithynia tentaculata) makes the leap to Lake Superior SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Faucet snail; Operculum; Great Lakes; Range expansion; St. Louis River estuary ID INVASION; PATTERNS AB The European-origin faucet snail (Bithynia tentaculata) has been present in the lower Laurentian Great Lakes since the late 1800s but only very recently reached Lake Superior. Surveys from 2011 through 2013 found faucet snails abundant and wide-spread in the St. Louis River Estuary (reinforcing the estuary's status as non-native species introduction hotspot), with scattered finds elsewhere along Lake Superior's southern shore. Faucet snails were found primarily in littoral areas that had been sampled with D-frame nets. We discuss what is known of the distribution and timeline of the faucet snail in lake Superior, and summarize morphological features helpful in distinguishing the faucet snail from other gastropods (e.g., the operculum). Given its potential for spread and impacts (including as waterfowl disease vector), the faucet snail warrants an elevated profile in non-native species monitoring, education, and decontamination measures in the upper Great Lakes. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Trebitz, Anett] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Shepard, Gerald] EMR Inc, Duluth, MN 55804 USA. [Brady, Valerie] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA. [Schmude, Kurt] Univ Wisconsin, Lake Super Res Inst, Superior, WI 54880 USA. RP Trebitz, A (reprint author), US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM trebitz.anett@epa.gov FU U.S. EPA through Great Lakes Restoration Initiative [GL-00E00500-2, GL-00E00612-0]; Minnesota Pollution Control Agency under contract CR [6403]; USFWS [232 F11AC00517, 30181AJ68]; Wisconsin Department of Natural Resources; LimnoTech FX We thank EPA and NRRI crews for sample collection efforts, and Adam Frankiewicz, Brent Gilbertson, Robert Hell, and Holly Wellard Kelly for taxonomic work. Funding came from U.S. EPA through Great Lakes Restoration Initiative agreements GL-00E00500-2 and GL-00E00612-0, from Minnesota Pollution Control Agency under contract CR#6403, from USFWS Cooperative Agreements 232 F11AC00517 and 30181AJ68, and from the Wisconsin Department of Natural Resources and LimnoTech. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of these agencies. This is contribution number 596 from the NRRI's Center for Water and the Environment. NR 16 TC 0 Z9 0 U1 3 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD DEC PY 2015 VL 41 IS 4 BP 1197 EP 1200 DI 10.1016/j.jglr.2015.09.013 PG 4 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CZ8OU UT WOS:000367359800027 ER PT J AU Brown, K Phillips, M Grulke, C Yoon, M Young, B McDougall, R Leonard, J Lu, JT Lefew, W Tan, YM AF Brown, Kathleen Phillips, Martin Grulke, Christopher Yoon, Miyoung Young, Bruce McDougall, Robin Leonard, Jeremy Lu, Jingtao Lefew, William Tan, Yu-Mei TI Reconstructing exposures from biomarkers using exposure-pharmacokinetic modeling - A case study with carbaryl SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Exposure reconstruction; Biomarker interpretation; Pharmacokinetic modeling; Physiologically based pharmacokinetic model; Carbaryl; Markov Chain Monte Carlo; Discretized Bayesian; Exposure conversion factor; CARES; Population-based biomonitoring ID VOLATILE ORGANIC-COMPOUNDS; HUMAN BIOMONITORING DATA; TO-OUTCOME MODEL; INSECTICIDE RESIDUES; REVERSE DOSIMETRY; DIETARY EXPOSURES; TRICHLOROETHYLENE; EPIDEMIOLOGY; PERCHLORATE; KINETICS AB Sources of uncertainty involved in exposure reconstruction for short half-life chemicals were characterized using computational models that link external exposures to biomarkers. Using carbaryl as an example, an exposure model, the Cumulative and Aggregate Risk Evaluation System (CARES), was used to generate time-concentration profiles for 500 virtual individuals exposed to carbaryl. These exposure profiles were used as inputs into a physiologically based pharrnacokinetic (PBPK) model to predict urinary biomarker concentrations. These matching dietary intake levels and biomarker concentrations were used to (1) compare three reverse dosimetry approaches based on their ability to predict the central tendency of the intake dose distribution; and (2) identify parameters necessary for a more accurate exposure reconstruction. This study illustrates the trade-offs between using non-iterative reverse dosimetry methods that are fast, less precise and iterative methods that are slow, more precise. This study also intimates the necessity of including urine flow rate and elapsed time between last dose and urine sampling as part of the biomarker sampling collection for better interpretation of urinary biomarker data of short biological half-life chemicals. Resolution of these critical data gaps can allow exposure reconstruction methods to better predict population-level intake doses from large biomonitoring studies. Published by Elsevier Ltd. C1 [Brown, Kathleen; Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Durham, NC 27709 USA. [Phillips, Martin] Minnesota Dept Hlth, St Paul, MN USA. [Grulke, Christopher] Lockheed Martin, Durham, NC USA. [Yoon, Miyoung] Hamner Inst Hlth Sci, Durham, NC USA. [Young, Bruce] Bayer CropSci, Durham, NC USA. [McDougall, Robin] Astra Zeneca, Boston, MA USA. [Leonard, Jeremy; Lu, Jingtao] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Lefew, William] Meemir Consulting, Durham, NC USA. RP Tan, YM (reprint author), US EPA, Natl Exposure Res Lab, Durham, NC 27709 USA. EM tan.cecilia@epa.gov OI Phillips, Martin/0000-0002-6282-529X; McDougall, Robin/0000-0002-5850-9075 FU Oak Ridge Institute for Science and Education's Research Participation Program at the US-Environmental Protection Agency FX The authors would like to thank Yuching Yang at the Hamner Institute for clarifications regarding the human PBPK model for carbaryl. The authors are also grateful to Drs. Rogelio Tornero-Velez, Lisa Baxter, and Roy Fortmann at the EPA for their review and comments. Jingtao Lu and Jeremy Leonard are funded by the Oak Ridge Institute for Science and Education's Research Participation Program at the US-Environmental Protection Agency. NR 51 TC 1 Z9 1 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD DEC PY 2015 VL 73 IS 3 BP 689 EP 698 DI 10.1016/j.yrtph.2015.10.031 PG 10 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA CZ7KX UT WOS:000367279400001 PM 26545325 ER PT J AU Benson, R Berry, D Lockey, J Brattin, W Hilbert, T LeMasters, G AF Benson, Robert Berry, David Lockey, James Brattin, William Hilbert, Timothy LeMasters, Grace TI Exposure-response modeling of non-cancer effects in humans exposed to Libby Amphibole Asbestos; update SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Asbestos; Libby amphibole; LAA; Pleural thickening; LPT; DPT; SIO ID PLEURAL PLAQUES; VERMICULITE AB The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO). Published by Elsevier Ltd. C1 [Benson, Robert; Berry, David] US EPA, Denver, CO 80202 USA. [Lockey, James; Hilbert, Timothy; LeMasters, Grace] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Lockey, James] Univ Cincinnati, Dept Internal Med, Div Pulm, Cincinnati, OH 45267 USA. [Brattin, William] SRC Inc, Denver, CO 80202 USA. RP Benson, R (reprint author), US EPA, 1595 Wynkoop St, Denver, CO 80202 USA. EM Benson.Bob@epa.gov FU U.S. EPA Region 8 FX U.S. EPA Region 8 provided all of the funding to support this research. NR 21 TC 4 Z9 4 U1 2 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD DEC PY 2015 VL 73 IS 3 BP 780 EP 789 DI 10.1016/j.yrtph.2015.10.019 PG 10 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA CZ7KX UT WOS:000367279400013 PM 26524929 ER PT J AU Bergman, A Becher, G Blumberg, B Bjerregaard, P Bornman, R Brandt, I Casey, SC Frouin, H Giudice, LC Heindel, JJ Iguchi, T Jobling, S Kidd, KA Kortenkamp, A Lind, PM Muir, D Ochieng, R Ropstad, E Ross, PS Skakkebaek, NE Toppari, J Vandenberg, LN Woodruff, TJ Zoeller, RT AF Bergman, Ake Becher, Georg Blumberg, Bruce Bjerregaard, Poul Bornman, Riana Brandt, Ingvar Casey, Stephanie C. Frouin, Heloise Giudice, Linda C. Heindel, Jerrold J. Iguchi, Taisen Jobling, Susan Kidd, Karen A. Kortenkamp, Andreas Lind, P. Monica Muir, Derek Ochieng, Roseline Ropstad, Erik Ross, Peter S. Skakkebaek, Niels Erik Toppari, Jorma Vandenberg, Laura N. Woodruff, Tracey J. Zoeller, R. Thomas TI Manufacturing doubt about endocrine disrupter science - A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012" SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Editorial Material DE Endocrine disruption; EDCs; Endocrine disruptors ID EPIDEMIOLOGY; FRAMEWORK; CAUSATION; MODE AB We present a detailed response to the critique of "State of the Science of Endocrine Disrupting Chemicals 2012" (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers not intimately familiar with the topic of endocrine disruption and therefore susceptible to false generalizations of bias and subjectivity. (C) 2015 The Authors. Published by Elsevier Inc. C1 [Bergman, Ake] Swedish Toxicol Sci Res Ctr Swetox, Sodertalje, Sweden. [Becher, Georg] Norwegian Inst Publ Hlth, Oslo, Norway. [Blumberg, Bruce; Casey, Stephanie C.] Univ Calif Irvine, Irvine, CA USA. [Bjerregaard, Poul] Univ Southern Denmark, Odense, Denmark. [Bornman, Riana] Univ Pretoria, Sch Hlth Syst & Publ Hlth, ZA-0002 Pretoria, South Africa. [Brandt, Ingvar; Lind, P. Monica] Uppsala Univ, Uppsala, Sweden. [Frouin, Heloise; Ross, Peter S.] Vancouver Aquarium Marine Sci Ctr, Vancouver, BC, Canada. [Giudice, Linda C.; Woodruff, Tracey J.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Heindel, Jerrold J.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Iguchi, Taisen] Natl Inst Basic Biol, Okazaki, Aichi 444, Japan. [Jobling, Susan; Kortenkamp, Andreas] Brunel Univ London, Uxbridge, Middx, England. [Kidd, Karen A.] Univ New Brunswick, New Brunswick, NJ USA. [Muir, Derek] Environm Canada, Burlington, ON L7R 4A6, Canada. [Ochieng, Roseline] Aga Khan Univ Hosp, Nairobi, Kenya. [Ropstad, Erik] Norwegian Univ Life Sci, Oslo, Norway. [Skakkebaek, Niels Erik] Univ Copenhagen, Copenhagen Univ Hosp, Copenhagen, Denmark. [Toppari, Jorma] Univ Turku, Turku, Finland. [Vandenberg, Laura N.; Zoeller, R. Thomas] Univ Massachusetts, Amherst, MA 01003 USA. RP Bergman, A (reprint author), Swedish Toxicol Sci Res Ctr Swetox, Sodertalje, Sweden. EM ake.bergman@swetox.se RI jobling, susan/N-9316-2016; OI Brandt, Ingvar/0000-0002-5386-2400; Bergman, Ake/0000-0003-3403-093X; Kidd, Karen/0000-0002-5619-1358; Bjerregaard, Poul/0000-0002-2065-7232 NR 22 TC 8 Z9 8 U1 6 U2 18 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD DEC PY 2015 VL 73 IS 3 BP 1007 EP 1017 DI 10.1016/j.yrtph.2015.07.026 PG 11 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA CZ7KX UT WOS:000367279400042 PM 26239693 ER PT J AU Cavallin, JE Schroeder, AL Jensen, KM Villeneuve, DL Blackwell, BR Carlson, K Kahl, MD LaLone, CA Randolph, EC Ankley, GT AF Cavallin, J. E. Schroeder, A. L. Jensen, K. M. Villeneuve, D. L. Blackwell, B. R. Carlson, K. Kahl, M. D. LaLone, C. A. Randolph, E. C. Ankley, G. T. TI Evaluation of whole-mount in situ hybridization as a tool for pathway-based toxicological research with early-life stage fathead minnows SO AQUATIC TOXICOLOGY LA English DT Article DE Development; Adverse outcome pathway; Fathead minnow; Endocrine disruption ID ADVERSE OUTCOME PATHWAYS; WATER TREATMENT PLANTS; EARLY FISH DEVELOPMENT; PIMEPHALES-PROMELAS; GENE-EXPRESSION; WASTE-WATER; CONCEPTUAL-FRAMEWORK; ZEBRAFISH; ESTROGENS; 17-ALPHA-ETHYNYLESTRADIOL AB Early-life stage fish can be more sensitive to toxicants than adults, so delineating mechanisms of perturbation of biological pathways by chemicals during this life stage is crucial. Whole-mount in situ hybridization (WISH) paired with quantitative real-time polymerase chain reaction (QPCR) assays can enhance pathway-based analyses through determination of specific tissues where changes in gene expression are occurring. While WISH has frequently been used in zebrafish (Danio rerio), this technology has not previously been applied to fathead minnows (Pimephales promelas), another well-established small fish model species. The objective of the present study was to adapt WISH to fathead minnow embryos and larvae, and use the approach to evaluate the effects of estrone, an environmentally-relevant estrogen receptor (ER) agonist. Embryos were exposed via the water to 0, 18 or 1800 ng estrone/L (0, 0.067 and 6.7 nM) for 3 or 6 days in a solvent-free, flow-through test system. Relative transcript abundance of three estrogen-responsive genes, estrogen receptor-alpha (esr1), cytochrome P450-aromatase B (cyp19b), and vitellogenin (vtg) was examined in pooled whole embryos using QPCR, and the spatial distribution of up-regulated gene transcripts was examined in individual fish using WISH. After 3 days of exposure to 1800 ng estrone/L, esr1 and cyp19b were significantly up-regulated, while vtg mRNA expression was not affected. After 6 days of exposure to 1800 ng estrone/L, transcripts for all three genes were significantly up-regulated. Corresponding WISH assays revealed spatial distribution of esr1 and vtg in the liver region, an observation consistent with activation of the hepatic ER. This study clearly demonstrates the potential utility of WISH, in conjunction with QPCR, to examine the mechanistic basis of the effects of toxicants on early-life stage fathead minnows. (C) 2015 Elsevier B.V. All rights reserved. C1 [Cavallin, J. E.] Univ Minnesota, Integrated Biosci Grad Program, Duluth, MN 55812 USA. [Schroeder, A. L.] Univ Minnesota, Water Resources Ctr, US EPA, Midcontinent Ecol Div,Off Res & Dev,Natl Hlth & E, Duluth, MN 55804 USA. [Jensen, K. M.; Villeneuve, D. L.; Kahl, M. D.; LaLone, C. A.; Randolph, E. C.; Ankley, G. T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Blackwell, B. R.] US EPA, ORISE Res Participat Program, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Midcontinent, Duluth, MN 55804 USA. [Carlson, K.] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. RP Cavallin, JE (reprint author), Univ Minnesota, Integrated Biosci Grad Program, 1035 Univ Dr, Duluth, MN 55812 USA. EM cavallin.jenna@epa.gov FU University of Minnesota-U.S. Environmental Protection Agency Cooperative Training Partnership FX We thank Krysta Nelson (EPA), Joe Korte (EPA), Kevin Lott (Badger Technical Services), and Dalma Martinovic-Weigelt (University of St. Thomas) for additional technical support and assistance. We also thank Jon Haselman for reviewing an earlier draft of this manuscript. J. Cavallin was supported in part by the University of Minnesota-U.S. Environmental Protection Agency Cooperative Training Partnership. This article has been reviewed in accordance with official U.S. EPA policy. Mention of products or trade names does not indicate endorsement or recommendation for use. Conclusions drawn in this study neither constitute nor reflect the view or policies of the U.S. EPA. NR 34 TC 1 Z9 1 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD DEC PY 2015 VL 169 BP 19 EP 26 DI 10.1016/j.aquatox.2015.10.002 PG 8 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA CZ3TV UT WOS:000367027800003 PM 26485527 ER PT J AU Wages, PA Lavrich, KS Zhang, ZF Cheng, WY Corteselli, E Gold, A Bromberg, P Simmons, SO Samet, JM AF Wages, Phillip A. Lavrich, Katelyn S. Zhang, Zhenfa Cheng, Wan-Yun Corteselli, Elizabeth Gold, Avram Bromberg, Philip Simmons, Steven O. Samet, James M. TI Protein Sulfenylation: A Novel Readout of Environmental Oxidant Stress SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID EPIDERMAL-GROWTH-FACTOR; TYROSINE-PHOSPHATASE 1B; SULFENIC ACID FORMATION; DIESEL EXHAUST; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HYDROGEN-PEROXIDE; REDOX REGULATION; OXIDATIVE STRESS; FACTOR RECEPTOR; CELLS AB Oxidative stress is a commonly cited mechanism of toxicity of environmental agents. Ubiquitous environmental chemicals such as the diesel exhaust component 1,2-naphthoquinone (1,2-NQ) induce oxidative stress by redox cycling, which generates hydrogen peroxide (H2O2). Cysteinyl thiolate residues on regulatory proteins are subjected to oxidative modification by H2O2 in physiological contexts and are also toxicological targets of,oxidant stress induced by environmental contaminants. We investigated whether exposure to environmentally relevant concentrations of 1,2-NQ can induce H2O2-dependent oxidation of cysteinyl thiols in regulatory proteins as a readout of oxidant stress in human airway epithelial cells. BEAS-2B cells were exposed to 0-1000 mu M 1,2-NQ for 0-30 min, and levels of H2O2 were measured by ratiometric spectrofluorometry of HyPer. H2O2-dependent protein sulfenylation was measured using immunohistochemistry, immunoblotting, and isotopic mass spectrometry. Catalase overexpression was used to investigate the relationship between H2O2 generation and protein sulfenylation in cells exposed to 1,2-NQ Multiple experimental approaches showed that exposure to 1,2-NQ at concentrations as low as 3 mu M induces H2O2-dependent protein sulfenylation in BEAS-2B cells. Moreover, the time of onset and duration of 1,2-NQ-induced sulfenylation of the regulatory proteins GAPDH and PTP1B showed significant differences. Oxidative modification of regulatory cysteinyl thiols in human lung cells exposed to relevant concentrations of an ambient air contaminant represents a novel marker of oxidative environmental stress. C1 [Wages, Phillip A.; Lavrich, Katelyn S.; Samet, James M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA. [Lavrich, Katelyn S.; Corteselli, Elizabeth; Gold, Avram] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Cheng, Wan-Yun] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Bromberg, Philip] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA. [Simmons, Steven O.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Samet, James M.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27711 USA. RP Samet, JM (reprint author), EPA Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM samet.james@epa.gov OI Simmons, Steven/0000-0001-9079-1069 FU NIEHS Toxicology Training Grant [T32 ES007126]; UNC-EPA [CR-83515201-0]; National Institute of Environmental Health Sciences [P30ES010126] FX P.A.W. was supported as a predoctoral candidate in part by NIEHS Toxicology Training Grant T32 ES007126 and UNC-EPA Training Agreement CR-83515201-0. This research was supported in part by a grant from the National Institute of Environmental Health Sciences (P30ES010126). NR 55 TC 4 Z9 4 U1 3 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD DEC PY 2015 VL 28 IS 12 BP 2411 EP 2418 DI 10.1021/acs.chemrestox.5b00424 PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA CZ5BT UT WOS:000367118000018 PM 26605980 ER PT J AU Kodavanti, PRS Joyce, ER Moore-Smith, DA Besas, J Richards, JE Beasley, TE Evansky, P Bushnell, PJ AF Kodavanti, Prasada Rao S. Royland, Joyce E. Moore-Smith, Debra A. Besas, Jonathan Richards, Judy E. Beasley, Tracey E. Evansky, Paul Bushnell, Philip J. TI Acute and subchronic toxicity of inhaled toluene in male Long-Evans rats: Oxidative stress markers in brain SO NEUROTOXICOLOGY LA English DT Article DE Toluene; Oxidative stress; Solvents; Antioxidants; Protein carbonyls; Aconitase; Neurotoxicity ID CENTRAL-NERVOUS-SYSTEM; NAD(P)H-QUINONE OXIDOREDUCTASE 1; ADULT RATS; LIPID-PEROXIDATION; MITOCHONDRIAL-DNA; ACUTE EXPOSURE; PPM TOLUENE; COMPLEX-I; ANTIOXIDANT; INHALATION AB The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute and one subchronic, were conducted to seek effects of the VOC, toluene, in rats and to compare the effects between acute and subchronic exposures. Adult male Long-Evans rats were exposed to toluene vapor (n = 6 per group) at a concentration of 0 or 1019 +/- 14 ppm for 6 h in the acute study and at 0 +/- 0, 10 +/- 1.4, 97 +/- 7, or 995 +/- 43 ppm for 6 h/d, 5 d/week for 13 weeks in the subchronic study. For the acute study, brains were dissected on ice within 30 min of the end of exposure, while for the subchronic study, brains were dissected 18 h after the last exposure. Frontal cortex, hippocampus, cerebellum, and striatum were assayed for a variety of oxidative stress (OS) parameters including total aconitase (TA), protein carbonyls, glutathione peroxidase (GPX), glutathione reductase (GRD), glutathione transferase (GST), gamma-glutamylcysteine synthetase (GCS), superoxide dismutase (SOD), total antioxidants (TAS), NADPH quinone oxidoreductase-1 (NQO1), and NADH ubiquinone reductase (UBIQ-RD) activities using commercially available kits. Following acute exposure, UBIQ-RD, GCS and GRD were increased significantly only in the cerebellum, while TAS was increased in frontal cortex. On the other hand, subchronic exposure affected several OS markers including increases in NQO1 and UBIQ-RD. The effect of subchronic toluene exposure on SOD and TAS was greater in the striatum than in the other brain regions. TA activity (involved in maintaining iron homeostasis and an indicator of DNA damage) was inhibited in striatum and cerebellum, increased in hippocampus, and unchanged in frontal cortex. Protein carbonyls increased significantly in both the frontal cortex and cerebellum. In general, the results showed that acute exposure to toluene affected OS parameters to a lesser extent than did subchronic exposure. These results suggest that toluene exposure induces OS in the brain and this may be a component of an adverse outcome pathway for some of the neurotoxic effects reported following toluene exposure. Published by Elsevier Inc. C1 [Kodavanti, Prasada Rao S.; Moore-Smith, Debra A.; Besas, Jonathan; Beasley, Tracey E.; Bushnell, Philip J.] US EPA, ORD, NHEERL, Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA. [Royland, Joyce E.] US EPA, ORD, NHEERL, Genet & Cellular Toxicol Branch, Res Triangle Pk, NC 27711 USA. [Richards, Judy E.] US EPA, ORD, NHEERL, Cardiopulm & Immunotoxicol Branch, Res Triangle Pk, NC 27711 USA. [Evansky, Paul] US EPA, ORD, NHEERL, Inhalat Toxicol Facil, Res Triangle Pk, NC 27711 USA. RP Kodavanti, PRS (reprint author), US EPA, NHEERL ORD, Tox Assessment Div, Neurotoxicol Branch, B 105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM kodavanti.prasada@epa.gov NR 67 TC 3 Z9 3 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2015 VL 51 BP 10 EP 19 DI 10.1016/j.neuro.2015.09.001 PG 10 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA CZ2SC UT WOS:000366953900002 PM 26343380 ER PT J AU Roberts, RA Aschner, M Calligaro, D Guilarte, TR Hanig, JP Herr, DW Hudzik, TJ Jeromin, A Kallman, MJ Liachenko, S Lynch, JJ Miller, DB Moser, VC O'Callaghan, JP Slikker, W Paule, MG AF Roberts, Ruth A. Aschner, Michael Calligaro, David Guilarte, Tomas R. Hanig, Joseph P. Herr, David W. Hudzik, Thomas J. Jeromin, Andreas Kallman, Mary J. Liachenko, Serguei Lynch, James J., III Miller, Diane B. Moser, Virginia C. O'Callaghan, James P. Slikker, William, Jr. Paule, Merle G. TI Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward SO TOXICOLOGICAL SCIENCES LA English DT Article DE neurotoxicity; biomarker; imaging; CSF; neurotoxicity ID TRAUMATIC BRAIN-INJURY; CEREBROSPINAL-FLUID BIOMARKERS; C-TERMINAL HYDROLASE-L1; 18 KDA TSPO; MULTIPLE-SCLEROSIS; IN-VIVO; ALZHEIMERS-DISEASE; TRIMETHYLTIN; RAT; NEURODEGENERATION AB Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from nonclinical to clinical data. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great potential due to the relative ease of sampling compared with tissues. Increasing evidence supports the potential utility of fluid-based biomarkers of neurotoxicity such as microRNAs, F-2-isoprostanes, translocator protein, glial fibrillary acidic protein, ubiquitin C-terminal hydrolase L1, myelin basic protein, microtubule-associated protein-2, and total tau. However, some of these biomarkers such as those in CSF require invasive sampling or are specific to one disease such as Alzheimer's, while others require further validation. Additionally, neuroimaging methodologies, including magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, may also serve as potential biomarkers and have several advantages including being minimally invasive. The development of biomarkers of neurotoxicity is a goal shared by scientists across academia, government, and industry and is an ideal topic to be addressed via the Health and Environmental Sciences Institute (HESI) framework which provides a forum to collaborate on key challenging scientific topics. Here we utilize the HESI framework to propose a consensus on the relative potential of currently described biomarkers of neurotoxicity to assess utility of the selected biomarkers using a nonclinical model. C1 [Roberts, Ruth A.] ApconiX, BioHub Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. [Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA. [Calligaro, David] Eli Lilly & Co, Div Eli Lilly & Co, Pharmacol Toxicol Res Lilly Res Labs, Lilly Corp Ctr, Indianapolis, IN 46285 USA. [Guilarte, Tomas R.] Columbia Univ, New York, NY 10032 USA. [Hanig, Joseph P.] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA. [Herr, David W.; Moser, Virginia C.] US EPA, NHEERL, Toxicol Assessment Div, Res Triangle Pk, NC 27711 USA. [Hudzik, Thomas J.] AbbVie Inc, N Chicago, IL 60064 USA. [Jeromin, Andreas; Lynch, James J., III] Quanterix Inc, Lexington, MA 02421 USA. [Kallman, Mary J.] Covance Inc, Indianapolis, IN 46214 USA. [Liachenko, Serguei; Slikker, William, Jr.] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. [Miller, Diane B.; O'Callaghan, James P.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Paule, Merle G.] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Jefferson, AR 72079 USA. RP Roberts, RA (reprint author), ApconiX, BioHub Alderley Pk, Macclesfield SK10 4TG, Cheshire, England. EM ruth.roberts@apconix.com FU NIEHS NIH HHS [P30 ES009089] NR 53 TC 2 Z9 2 U1 4 U2 19 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD DEC PY 2015 VL 148 IS 2 BP 332 EP 340 DI 10.1093/toxsci/kfv188 PG 9 WC Toxicology SC Toxicology GA CZ6FB UT WOS:000367195500001 PM 26609132 ER PT J AU Webster, AF Zumbo, P Fostel, J Gandara, J Hester, SD Recio, L Williams, A Wood, CE Yauk, CL Mason, CE AF Webster, A. Francina Zumbo, Paul Fostel, Jennifer Gandara, Jorge Hester, Susan D. Recio, Leslie Williams, Andrew Wood, Charles E. Yauk, Carole L. Mason, Christopher E. TI Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues SO TOXICOLOGICAL SCIENCES LA English DT Article DE RNA-seq; microarray; toxicogenomics; FFPE; archival RNA; biorepositories ID FEMALE B6C3F1 MICE; RNA-SEQ; RISK-ASSESSMENT; DIFFERENTIAL EXPRESSION; SYSTEMATIC VARIATION; CELL-PROLIFERATION; CARCINOGEN FURAN; MICROARRAY DATA; QUALITY-CONTROL; LINEAR-MODEL AB Formalin-fixed paraffin-embedded (FFPE) tissue samples represent a potentially invaluable resource for transcriptomic research. However, use of FFPE samples in genomic studies has been limited by technical challenges resulting from nucleic acid degradation. Here we evaluated gene expression profiles derived from fresh-frozen (FRO) and FFPE mouse liver tissues preserved in formalin for different amounts of time using 2 DNA microarray protocols and 2 whole-transcriptome sequencing (RNA-seq) library preparation methodologies. The ribo-depletion protocol outperformed the other methods by having the highest correlations of differentially expressed genes (DEGs), and best overlap of pathways, between FRO and FFPE groups. The effect of sample time in formalin (18 h or 3 weeks) on gene expression profiles indicated that test article treatment, not preservation method, was the main driver of gene expression profiles. Meta- and pathway analyses indicated that biological responses were generally consistent for 18 h and 3 week FFPE samples compared with FRO samples. However, clear erosion of signal intensity with time in formalin was evident, and DEG numbers differed by platform and preservation method. Lastly, we investigated the effect of time in paraffin on genomic profiles. Ribo-depletion RNA-seq analysis of 8-, 19-, and 26-year-old control blocks resulted in comparable quality metrics, including expected distributions of mapped reads to exonic, untranslated region, intronic, and ribosomal fractions of the transcriptome. Overall, our results indicate that FFPE samples are appropriate for use in genomic studies in which frozen samples are not available, and that ribo-depletion RNA-seq is the preferred method for this type of analysis in archival and long-aged FFPE samples. C1 [Webster, A. Francina; Williams, Andrew; Yauk, Carole L.] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada. [Webster, A. Francina] Carleton Univ, Dept Biol, Ottawa, ON K1S 5B6, Canada. [Zumbo, Paul; Gandara, Jorge; Mason, Christopher E.] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA. [Fostel, Jennifer] NIEHS, Res Triangle Pk, NC 27709 USA. [Hester, Susan D.; Wood, Charles E.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA. [Recio, Leslie] ILS Inc, Res Triangle Pk, NC 27709 USA. [Mason, Christopher E.] Feil Family Brain & Mind Res Inst BMRI, New York, NY 10021 USA. [Mason, Christopher E.] HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10065 USA. RP Yauk, CL (reprint author), Hlth Canada, HECSB, ERHSD, Environm Hlth Sci & Res Bur, Bldg 8,P-L 0803A,50 Colombine Driveway, Ottawa, ON K1A 0K9, Canada. EM Carole.Yauk@hc-sc.gc.ca; chm2042@med.cornell.edu FU NTP [NO1-ES-55536] FX We thank the ILS animal care group for performing the furan mouse exposures and fixing these tissues, and the NTP contract NO1-ES-55536 for preparing the archival RNA. The authors greatly acknowledge Weill Cornell Epigenomics Core contribution and technical support from Jennifer A. Busuttil and Caroline Sheridan. We also thank the Bert L. and N. Kuggie Vallee Foundation Young Investigator Award and the WorldQuant Foundation. The authors also acknowledge Dr. Matt Meier and Dr Ivy Moffat for helpful comments on the article. NR 48 TC 4 Z9 4 U1 2 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD DEC PY 2015 VL 148 IS 2 BP 460 EP 472 DI 10.1093/toxsci/kfv195 PG 13 WC Toxicology SC Toxicology GA CZ6FB UT WOS:000367195500011 PM 26361796 ER PT J AU Howdeshell, KL Rider, CV Wilson, VS Furr, JR Lambright, CR Gray, LE AF Howdeshell, Kembra L. Rider, Cynthia V. Wilson, Vickie S. Furr, Johnathan R. Lambright, Christy R. Gray, L. Earl, Jr. TI Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats SO TOXICOLOGICAL SCIENCES LA English DT Article DE dose addition; phthalates; postnatal developmental toxicity; male reproductive tract; endocrine disruptors; mixture models ID N-BUTYL PHTHALATE; ALTERS SEXUAL-DIFFERENTIATION; CUMULATIVE RISK-ASSESSMENT; SPRAGUE-DAWLEY RATS; IN-UTERO EXPOSURE; DI(N-BUTYL) PHTHALATE; BENZYL PHTHALATE; GENE-EXPRESSION; DIETHYLHEXYL PHTHALATE; DEVELOPMENTAL TOXICITY AB Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty determining the biological relevance of reduction in fetal testosterone (T) on postnatal development. The objectives of the current study were 2-fold: (1) to test whether a mixture model of dose addition based on the fetal T production data of individual phthalates would predict the effects of a 5 phthalate mixture on androgen-sensitive postnatal male reproductive tract development, and (2) to determine the biological relevance of the reductions in fetal T to induce abnormal postnatal reproductive tract development using data from the mixture study. We administered a dose range of the mixture (60, 40, 20, 10, and 5% of the top dose used in the previous fetal T production study consisting of 300 mg/kg per chemical of benzyl butyl (BBP), di(n)butyl (DBP), diethyl hexyl phthalate (DEHP), di-isobutyl phthalate (DiBP), and 100 mg dipentyl (DPP) phthalate/kg; the individual phthalates were present in equipotent doses based on their ability to reduce fetal T production) via gavage to Sprague Dawley rat dams on GD8-postnatal day 3. We compared observed mixture responses to predictions of dose addition based on the previously published potencies of the individual phthalates to reduce fetal T production relative to a reference chemical and published postnatal data for the reference chemical (called DA(ref)). In addition, we predicted DA (called DA(all)) and response addition (RA) based on logistic regression analysis of all 5 individual phthalates when complete data were available. DA (ref) and DA (all) accurately predicted the observed mixture effect for 11 of 14 endpoints. Furthermore, reproductive tract malformations were seen in 17-100% of F1 males when fetal T production was reduced by about 25-72%, respectively. C1 [Howdeshell, Kembra L.; Rider, Cynthia V.] NIEHS, Div Natl Toxicol Program NTP, Res Triangle Pk, NC 27709 USA. [Wilson, Vickie S.; Furr, Johnathan R.; Lambright, Christy R.; Gray, L. Earl, Jr.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Labs, Toxicol Assessment Div TAD,Reprod Toxicol Branch, Res Triangle Pk, NC 27711 USA. RP Howdeshell, KL (reprint author), NIEHS, Div Natl Toxicol Program NTP, POB 12233, Res Triangle Pk, NC 27709 USA. EM howdeshellkl@niehs.nih.gov OI Wilson, Vickie/0000-0003-1661-8481 FU NIH, National Institute of Environmental Health Sciences FX We wish to thank Dr Eve Mylchreest for providing us the original data from her 1998 DBP study (Mylchreest et al., 1998). We thank Mary Cardon and Dr Phillip Hartig for their help in fetal necropsies, Dr Dieldrich Bermudez for his assistance with adult necropsies, and Dr Donald A. Smith for his mathematical advice. This work was supported in part by the NIH, National Institute of Environmental Health Sciences. This research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. EPA, and has been approved for publication. Approval does not necessarily reflect the views and policies of the U.S. EPA nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 50 TC 5 Z9 5 U1 7 U2 14 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD DEC PY 2015 VL 148 IS 2 BP 488 EP 502 DI 10.1093/toxsci/kfv196 PG 15 WC Toxicology SC Toxicology GA CZ6FB UT WOS:000367195500013 PM 26350170 ER PT J AU Jeong, CH Postigo, C Richardson, SD Simmons, JE Kimura, SY Marinas, BJ Barcelo, D Liang, P Wagner, ED Plewa, MJ AF Jeong, Clara H. Postigo, Cristina Richardson, Susan D. Simmons, Jane Ellen Kimura, Susana Y. Marinas, Benito J. Barcelo, Damia Liang, Pei Wagner, Elizabeth D. Plewa, Michael J. TI Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MAMMALIAN-CELL CYTOTOXICITY; CHLORIDE METABOLITE CHLOROACETALDEHYDE; CHEMICALLY-INDUCED ANEUPLOIDY; HAMSTER OVARY CELLS; FOR-GESTATIONAL-AGE; VINYL-CHLORIDE; IN-VITRO; BLADDER-CANCER; COMET ASSAY; HALOGENATED ACETALDEHYDES AB The introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (HALs) are the third largest group by weight of identified DBPs in drinking water. The primary objective of this study was to analyze the occurrence and comparative toxicity of the emerging HAL DBPs. A new HAL DBP, iodoacetaldehyde (IAL) was identified. This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells. The rank order of HAL cytotoxicity is tribromoacetaldehyde (TBAL) chloroacetaldehyde (CAL) > dibromoacetaldehyde (DBAL) approximate to bromochloroacetaldehyde (BCAL) approximate to dibromochloroacetaldehyde (DBCAL) > IAL > bromoacetaldehyde (BAL) approximate to bromodichloroacetaldehyde (BDCAL) > dichloroacetaldehyde (DCAL) > trichloroacetaldehyde (TCAL). The HALs were highly cytotoxic compared to other DBP chemical classes. The rank order of HAL genotoxicity is DBAL > CAL approximate to DBCAL > TBAL approximate to BAL > BDCAL > BCAL approximate to DCAL > IAL. TCAL was not genotoxic. Because of their toxicity and abundance, further research is needed to investigate their mode of action to protect the public health and the environment. C1 [Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA. [Postigo, Cristina; Barcelo, Damia] Inst Environm Assessment & Water Res IDAEA CSIC, Dept Environm Chem, Water & Soil Qual Res Grp, Barcelona 08034, Barcelona, Spain. [Richardson, Susan D.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Simmons, Jane Ellen] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. [Kimura, Susana Y.; Marinas, Benito J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Jeong, Clara H.; Kimura, Susana Y.; Marinas, Benito J.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Safe Global Water Inst, Urbana, IL 61801 USA. [Jeong, Clara H.; Kimura, Susana Y.; Marinas, Benito J.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Sci & Technol Ctr Adv Mat Purificat Water Syst, Urbana, IL 61801 USA. [Barcelo, Damia] Parc Cient & Tecnol Univ Girona, Catalan Inst Water Res ICRA, Girona 17003, Girona, Spain. [Liang, Pei] Cent China Normal Univ, Dept Chem, Wuhan 430079, Hubei, Peoples R China. RP Plewa, MJ (reprint author), Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA. EM mplewa@illinois.edu FU U.S. EPA STAR Grant [R834867]; Center of Advanced Materials for the Purification of Water with Systems (WaterCAMPWS), a National Science Foundation Science and Technology Center [CTS-0120978]; NIEHS Predoctoral Fellowship [T32 ES007326]; European Union [274379]; Generalitat de Catalunya [2014 SGR 291 - ICRA, 2014 SGR 418]; U.S. Environmental Protection Agency FX We would like to thank the drinking water treatment plants for generously providing us with samples and Yusupha Sey for excellent technical support. This work was supported by the U.S. EPA STAR Grant R834867. We appreciate support by the Center of Advanced Materials for the Purification of Water with Systems (WaterCAMPWS), a National Science Foundation Science and Technology Center, under Award CTS-0120978. C.J. was supported by a NIEHS Predoctoral Fellowship under Grant No. T32 ES007326. C.P. acknowledges support from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 274379 (Marie Curie IOF). This work has been financially supported by the Generalitat de Catalunya (Consolidated Research Groups "2014 SGR 418 - Water and Soil Quality Unit" and 2014 SGR 291 - ICRA). This work reflects only the authors' views. The EU is not liable for any use that may be made of the information contained therein. The information in this document was funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 100 TC 16 Z9 17 U1 27 U2 93 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 1 PY 2015 VL 49 IS 23 BP 13749 EP 13759 DI 10.1021/es506358x PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CX8CP UT WOS:000365930500005 PM 25942416 ER PT J AU Chen, CY Zepp, RG AF Chen, Chia-Ying Zepp, Richard G. TI Probing Photosensitization by Functionalized Carbon Nanotubes SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID STEADY-STATE CONCENTRATIONS; NATURAL ORGANIC-MATTER; AGGREGATION KINETICS; RAMAN-SPECTROSCOPY; TRIPLET-STATE; COLLOIDAL PROPERTIES; AQUATIC ENVIRONMENT; ENERGY-TRANSFER; SINGLET OXYGEN; IONIC-STRENGTH AB Carbon nanotubes (CNTs) photosensitize the production of reactive oxygen species that may damage organisms by biomembrane oxidation or mediate environmental transformations of CNTs. Photosensitization by derivatized carbon nanotubes from various synthetic methods, and thus with different intrinsic characteristics (e.g., diameter and electronic properties), has been investigated under environmentally relevant aquatic conditions. We used the CNT-sensitized photoisomerization of sorbic acid ((2E,4E)-hexa-2,4-dienoic acid) and singlet oxygen formation to quantify the triplet states ((CNT)-C-3*) formed upon irradiation of selected single-walled carbon nanotubes (SWCNTs) and multiwalled carbon nanotubes (MWENTs). The CNTs used in our studies were derivatized by carboxyl groups to facilitate their dispersion in water. Results indicate that high-defect-density (thus well-stabilized), small-diameter, and semiconducting-rich CNTs have higher-measured excited triplet state formation and therefore singlet oxygen (O-1(2)) yield. Derivatized SWCNTs were significantly more photoreactive than derivatized MWCNTs. Moreover, addition of sodium chloride resulted in increased aggregation and small increases in O-1(2) production of CNTs. The most photoreactive CNTs exhibited comparable photoreactivity (in terms of (CNT)-C-3* formation and O-1(2) yield) to reference natural organic matter (NOM) under sunlight irradiation with the same mass-based concentration. Selected reference NOM could therefore be useful in evaluating environmental photoreactivity or intended antibacterial applications of CNTs. C1 [Chen, Chia-Ying] US EPA, Natl Res Council Associate, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. [Zepp, Richard G.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. [Chen, Chia-Ying] Natl Chung Hsing Univ, Dept Environm Engn, Taichung 402, Taiwan. RP Chen, CY (reprint author), US EPA, Natl Res Council Associate, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. EM chiayingchen13@gmail.com; zepp.richard@epa.gov FU National Research Council FX This paper has been reviewed in accordance with the U.S. Environmental Protection Agency's (U.S. EPA) peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use by the U.S. EPA. Financial support provided by National Research Council (C.-Y.C.) is acknowledged. We thank Dr. John Washington and Tom Jenkins for helping with absorbance measurements using the UV-visible spectrometer equipped with an integrating sphere attachment, Dr. Jack Jones for help with N2 glovebox, and Ernest Walton and Jeffrey Hendel of Science and Ecosystem Support Division, USEPA-Region 4 for technical assistance with metal measurements. NR 55 TC 6 Z9 7 U1 9 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 1 PY 2015 VL 49 IS 23 BP 13835 EP 13843 DI 10.1021/acs.est.5b01041 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CX8CP UT WOS:000365930500014 PM 26186124 ER PT J AU Beer, KD Gargano, JW Roberts, VA Hill, VR Garrison, LE Kutty, PK Hilborn, ED Wade, TJ Fullerton, KE Yoder, JS AF Beer, Karlyn D. Gargano, Julia W. Roberts, Virginia A. Hill, Vincent R. Garrison, Laurel E. Kutty, Preeta K. Hilborn, Elizabeth D. Wade, Timothy J. Fullerton, Kathleen E. Yoder, Jonathan S. TI Surveillance for Waterborne Disease Outbreaks Associated With Drinking Water - United States, 2011-2012 (Reprinted from AMERICAN JOURNAL OF TRANSPLANTATION vol 64, pg 842, 2015) SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Reprint ID MYCOBACTERIUM; LEGIONELLA C1 [Beer, Karlyn D.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Beer, Karlyn D.; Gargano, Julia W.; Roberts, Virginia A.; Hill, Vincent R.; Fullerton, Kathleen E.; Yoder, Jonathan S.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Garrison, Laurel E.; Kutty, Preeta K.] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Hilborn, Elizabeth D.; Wade, Timothy J.] US EPA, Athens, GA USA. RP Beer, KD (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM kbeer@cdc.gov NR 9 TC 0 Z9 0 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD DEC PY 2015 VL 15 IS 12 BP 3260 EP 3267 DI 10.1111/ajt.13602 PG 8 WC Surgery; Transplantation SC Surgery; Transplantation GA CX2NP UT WOS:000365534100029 ER PT J AU Padgett, LE Anderson, B Liu, C Ganini, D Mason, RP Piganelli, JD Mathews, CE Tse, HM AF Padgett, Lindsey E. Anderson, Brian Liu, Chao Ganini, Douglas Mason, Ronald P. Piganelli, Jon D. Mathews, Clayton E. Tse, Hubert M. TI Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes SO DIABETES LA English DT Article ID CHRONIC GRANULOMATOUS-DISEASE; NADPH OXIDASE; RECEPTOR STIMULATION; OXIDATIVE BURST; BETA-CELLS; MACROPHAGES; ACTIVATION; ARTHRITIS; MICE; AUTOIMMUNITY AB Reactive oxygen species (ROS) play prominent roles in numerous biological systems. While classically expressed by neutrophils and macrophages, CD4 T cells also express NADPH oxidase (NOX), the superoxide-generating multisubunit enzyme. Our laboratory recently demonstrated that superoxide-deficient nonobese diabetic (NOD. Ncf1(m1J)) mice exhibited a delay in type 1 diabetes (T1D) partially due to blunted IFN-gamma synthesis by CD4 T cells. For further investigation of the roles of superoxide on CD4 T-cell diabetogenicity, the NOD.BDC-2.5.Ncf(m1J) (BDC-2.5.Ncf1(m1J)) mouse strain was generated, possessing autoreactive CD4 T cells deficient in NOX-derived superoxide. Unlike NOD.Ncfr(m1J), stimulated BDC-2.5.Ncf1(m1J) CD4 T cells and splenocytes displayed elevated synthesis of Th1 cytokines and chemokines. Superoxide-deficient BDC-2.5 mice developed spontaneous T1D, and CD4 T cells were more diabetogenic upon adoptive transfer into NOD.Rag recipients due to a skewing toward impaired Treg suppression. Exogenous superoxide blunted exacerbated Th1 cytokines and proinflammatory chemokines to approximately wild-type levels, concomitant with reduced IL-12R beta 2 signaling and P-STAT4 (Y693) activation. These results highlight the importance of NOX-derived superoxide in curbing autoreactivity due, in part, to control of Treg function and as a redox-dependent checkpoint of effector T-cell responses. Ultimately, our studies reveal the complexities of free radicals in CD4 T-cell responses. C1 [Padgett, Lindsey E.; Anderson, Brian; Tse, Hubert M.] Univ Alabama Birmingham, Sch Med, Dept Microbiol, Comprehens Diabet Ctr, Birmingham, AL 35294 USA. [Liu, Chao; Mathews, Clayton E.] Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL USA. [Ganini, Douglas; Mason, Ronald P.] NIH, Free Rad Metabolites Immun Inflammat & Dis Lab, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Piganelli, Jon D.] Univ Pittsburgh, Sch Med, Dept Surg Immunol & Pathol, Pittsburgh, PA USA. RP Tse, HM (reprint author), Univ Alabama Birmingham, Sch Med, Dept Microbiol, Comprehens Diabet Ctr, Birmingham, AL 35294 USA. EM htse@uab.edu FU National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 award [DK-099550]; American Diabetes Association Career Development Award [7-12-CD-11]; P30 Pilot Feasibility award from the UAB Comprehensive Diabetes Center/Diabetes Research Training Center; NIH National Institute of Allergy and Infectious Diseases [5T32AI007051-35]; Immunologic Diseases and Basic Immunology T32 training grant; Travel for Techniques Program Award from the American Association for Immunologists, Inc.; NIH/NIDDK R01 award [DK-074656]; JDRF; Intramural Research Program of the National Institute of Environmental Health Sciences/NIH; Animal Resources Program [G20RR025858]; Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center: Analytic and Preparative Cytometry Facility [P30 AR48311]; Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center: Epitope Recognition Immunoreagent Core [P30 AR48311] FX This work was supported by a National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 award (DK-099550), an American Diabetes Association Career Development Award (7-12-CD-11), a P30 Pilot Feasibility award from the UAB Comprehensive Diabetes Center/Diabetes Research Training Center, an NIH National Institute of Allergy and Infectious Diseases (5T32AI007051-35) Immunologic Diseases and Basic Immunology T32 training grant (to L.E.P.), and a Travel for Techniques Program Award from the American Association for Immunologists, Inc. (to H.M.T.). Further support was provided by an NIH/NIDDK R01 award (DK-074656) and a grant from the JDRF (to C.E.M.). This research was partially supported by the Intramural Research Program of the National Institute of Environmental Health Sciences/NIH. The following core facilities of UAB were used to generate data for the manuscript: Animal Resources Program (G20RR025858, Sam Cartner); the Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center: Analytic and Preparative Cytometry Facility (P30 AR48311, John D. Mountz); and the Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center: Epitope Recognition Immunoreagent Core (P30 AR48311, Mary Ann Accavitti-Loper). NR 47 TC 3 Z9 3 U1 0 U2 3 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0012-1797 EI 1939-327X J9 DIABETES JI Diabetes PD DEC PY 2015 VL 64 IS 12 BP 4171 EP 4183 DI 10.2337/db15-0546 PG 13 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CX8DN UT WOS:000365932900022 PM 26269022 ER PT J AU Johns, LE Cooper, GS Galizia, A Meeker, JD AF Johns, Lauren E. Cooper, Glinda S. Galizia, Audrey Meeker, John D. TI Exposure assessment issues in epidemiology studies of phthalates SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Phthalates; Exposure assessment; Environmental epidemiology; Biomarkers; Metabolites; Trends; Temporal reliability; Biomonitoring ID DEUTERIUM-LABELED DEHP; TEMPORAL VARIABILITY; URINARY CONCENTRATIONS; DI(2-ETHYLHEXYL)PHTHALATE DEHP; CHEMICAL-EXPOSURE; PREGNANT-WOMEN; UNITED-STATES; US POPULATION; METABOLITES; SERUM AB Purpose: The purpose of this paper is to review exposure assessment issues that need to be addressed in designing and interpreting epidemiology studies of phthalates, a class of chemicals commonly used in consumer and personal care products. Specific issues include population trends in exposure, temporal reliability of a urinary metabolite measurement, and how well a single urine sample may represent longer-term exposure. The focus of this review is on seven specific phthalates: diethyl phthalate (DEP); di-n-butyl phthalate (DBP); diisobutyl phthalate (DiBP); butyl benzyl phthalate (BBzP); di(2-ethylhexyl) phthalate (DEHP); diisononyl phthalate (DiNP); and diisodecyl phthalate (DiDP). Methods: Comprehensive literature search using multiple search strategies. Results: Since 2001, declines in population exposure to DEP, BBzP, DBP, and DEHP have been reported in the United States and Germany, but DEHP exposure has-increased in China. Although the half-lives of various phthalate metabolites are relatively short (3 to 18 h), the intraclass correlation coefficients (ICCs) for phthalate metabolites, based on spot and first morning urine samples collected over a week to several months, range from weak to moderate, with a tendency toward higher ICCs (greater temporal stability) for metabolites of the shorter-chained (DEP, DBP, DiBP and BBzP, ICCs generally 0.3 to 0.6) compared with those of the longer-chained (DEHP, DiNP, DiDP, ICCs generally 0.1 to 03) phthalates. Additional research on optimal approaches to addressing the issue of urine dilution in studies of associations between biomarkers and different type of health effects is needed. Conclusions: In conclusion, the measurement of urinary metabolite concentrations in urine could serve as a valuable approach to estimating exposure to phthalates in environmental epidemiology studies. Careful consideration of the strengths and limitations of this approach when interpreting study results is required. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Johns, Lauren E.; Meeker, John D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48103 USA. [Cooper, Glinda S.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Galizia, Audrey] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Edison, NJ 08837 USA. RP Meeker, JD (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48103 USA. EM laujohns@umich.edu; Cooper.Glinda@epa.gov; Galizia.Audrey@epa.gov; meekerj@umich.edu OI Meeker, John/0000-0001-8357-5085 FU National Institute of Environmental Health Sciences (NIEHS) [P20ES018171, P42ES017198, R01ES018872, P30ES017885, P01ES022844, T32ES007062]; US Environmental Protection Agency (USEPA) [RD834800, RD835436] FX The authors thank Dr. Krista Christensen for her review of an earlier version of this manuscript. This work is supported by grants P20ES018171, P42ES017198, R01ES018872, P30ES017885, P01ES022844, and T32ES007062, from the National Institute of Environmental Health Sciences (NIEHS) and RD834800 and RD835436 from the US Environmental Protection Agency (USEPA). The views expressed are those of the authors and do not necessarily reflect the policies of the US Environmental Protection Agency. NR 89 TC 18 Z9 18 U1 14 U2 43 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD DEC PY 2015 VL 85 BP 27 EP 39 DI 10.1016/j.envint.2015.08.005 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX0CF UT WOS:000365363800004 PM 26313703 ER PT J AU Brandt, KK Amezquita, A Backhaus, T Boxall, A Coors, A Heberer, T Lawrence, JR Lazorchak, J Schonfeld, J Snape, JR Zhu, YG Topp, E AF Brandt, Kristian K. Amezquita, Alejandro Backhaus, Thomas Boxall, Alistair Coors, Anja Heberer, Thomas Lawrence, John R. Lazorchak, James Schoenfeld, Jens Snape, Jason R. Zhu, Yong-Guan Topp, Edward TI Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganisms SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Antimicrobials; Ecosystem services; Ecotoxicology; Environmental risk assessment; Microbial ecology; Pharmaceuticals ID INDUCED COMMUNITY TOLERANCE; SOIL MICROBIAL-COMMUNITY; PERSONAL CARE PRODUCTS; LINEAR ALKYLBENZENE SULFONATE; LEVEL PHYSIOLOGICAL PROFILES; ECOLOGICAL RISK-ASSESSMENT; BACTERIAL COMMUNITY; ECOSYSTEM SERVICES; RESISTANCE GENES; HUMAN HEALTH AB Antibiotics play a pivotal role in the management of infectious disease in humans, companion animals, livestock, and aquaculture operations at a global scale. Antibiotics are produced, consumed, and released into the environment at an unprecedented scale causing concern that the presence of antibiotic residues may adversely impact aquatic and terrestrial ecosystems. Here we critically review the ecotoxicological assessment of antibiotics as related to environmental risk assessment (ERA). We initially discuss the need for more specific protection goals based on the ecosystem service concept, and suggest that the ERA of antibiotics, through the application of a mode of toxic action approach, should make more use of ecotoxicological endpoints targeting microorganisms (especially bacteria) and microbial communities. Key ecosystem services provided by microorganisms and associated ecosystem service-providing units (e.g. taxa or functional groups) are identified. Approaches currently available for elucidating ecotoxicological effects on microorganisms are reviewed in detail and we conclude that microbial community-based tests should be used to complement single-species tests to offer more targeted protection of key ecosystem services. Specifically, we propose that ecotoxicological tests should not only assess microbial community function, but also microbial diversity ('species' richness) and antibiotic susceptibility. Promising areas for future basic and applied research of relevance to ERA are highlighted throughout the text. In this regard, the most fundamental knowledge gaps probably relate to our rudimentary understanding of the ecological roles of antibiotics in nature and possible adverse effects of environmental pollution with subinhibitory levels of antibiotics. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Brandt, Kristian K.] Univ Copenhagen, Dept Plant & Environm Sci, Frederiksberg, Denmark. [Brandt, Kristian K.] Sino Danish Ctr Educ & Res, Beijing, Peoples R China. [Amezquita, Alejandro] Unilever Safety & Environm Assurance Ctr, Sharnbrook, Beds, England. [Backhaus, Thomas] Univ Gothenburg, Dept Biol & Environm Sci, Gothenburg, Sweden. [Boxall, Alistair] Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England. [Coors, Anja] ECT Oekotoxikol GmbH, Florsheim am Main, Germany. [Heberer, Thomas] Fed Off Consumer Protect & Food Safety, Dept Vet Drugs 3, Berlin, Germany. [Lawrence, John R.] Environm Canada, Saskatoon, SK, Canada. [Lazorchak, James] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Schoenfeld, Jens] Umweltbundesamt Fed Environm Agcy, Dessau, Germany. [Snape, Jason R.] AstraZeneca Global Environm, Alderley Pk, England. [Zhu, Yong-Guan] Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen, Peoples R China. [Topp, Edward] Agr & Agri Food Canada, London, ON, Canada. RP Topp, E (reprint author), Agr & Agri Food Canada, London, ON, Canada. EM kkb@plen.ku.dk; Ed.Topp@AGR.GC.CA RI Zhu, Yong-Guan/A-1412-2009; Brandt, Kristian Koefoed/I-3240-2012; CAS, KLUEH-Cooperation/E-1148-2017; CAS, KLUEH/G-8978-2016; OI Zhu, Yong-Guan/0000-0003-3861-8482; Brandt, Kristian Koefoed/0000-0001-7886-9708; Topp, Ed/0000-0002-8273-9372; Lazorchak, James/0000-0002-7354-7571 FU Canadian Society of Microbiologists; AstraZeneca Global Safety, Health and Environment; Pfizer Animal Health; F. Hoffman-La Roche Ltd.; GlaxoSmithKline; Unilever; Huvepharma; American Cleaning Institute; Canadian Animal Health Institute; German Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety; Health Canada; Public Health Agency of Canada; Center for Environmental and Agricultural Microbiology (CREAM); Villum Foundation FX This manuscript was conceived at a Workshop (Antimicrobial Resistance in the Environment: Assessing and Managing Effects of Anthropogenic Activities) held in Montebello, Quebec, Canada on March 4-8, 2012. The workshop was sponsored by the Canadian Society of Microbiologists with financial support from AstraZeneca Global Safety, Health and Environment, Pfizer Animal Health, F. Hoffman-La Roche Ltd., GlaxoSmithKline, Unilever, Huvepharma, the American Cleaning Institute, the Canadian Animal Health Institute, the German Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety, Health Canada, and the Public Health Agency of Canada. Additional financial support was provided by Center for Environmental and Agricultural Microbiology (CREAM) hosted at University of Copenhagen and financed by the Villum Foundation. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the US Environmental Protection Agency or the German Federal Environment Agency. NR 249 TC 9 Z9 9 U1 38 U2 140 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD DEC PY 2015 VL 85 BP 189 EP 205 DI 10.1016/j.envint.2015.09.013 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA CX0CF UT WOS:000365363800021 PM 26411644 ER PT J AU Reddy, TV Flick, R Lazorchak, JM Smith, ME Wiechman, B Lattier, DL AF Reddy, Tirumuru V. Flick, Robert Lazorchak, James M. Smith, Mark E. Wiechman, Barry Lattier, David L. TI Experimental paradigm for in-laboratory proxy aquatic studies under conditions of static, non-flow-through chemical exposures SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Transcriptomics; Contaminant of emerging concern; Ecotoxicogenomic; Endocrine-disrupting compound; Estrogenic compound ID ENDOCRINE-DISRUPTING CHEMICALS; MINNOW CYPRINODON-VARIEGATUS; FLOUNDER PLATICHTHYS-FLESUS; TROUT ONCORHYNCHUS-MYKISS; MEDAKA ORYZIAS-LATIPES; ESTROGENIC ACTIVITY; VITELLOGENIN INDUCTION; PIMEPHALES-PROMELAS; JUVENILE ALLIGATORS; SYNTHETIC ESTROGENS AB Endocrine-disrupting chemicals (EDCs) such as 17-ethynylestradiol, 17-estradiol, estrone, and para-nonylphenol have been measured in wastewater-treatment plant effluents, surface waters, sediments, and sludge and have been shown to induce liver-specific vitellogenin (vtg) messenger RNA in male fathead minnows (Pimephales promelas). The purpose of the present study was to establish minimal concentrations of select EDCs necessary to induce transcription of vtg in 48-h static renewal exposures, as measured by quantitative real-time thermal cycle amplification. Adult males were exposed to 17-ethynylestradiol, 17-estradiol, estrone, and para-nonylphenol. Dose-dependent increases in vtg expression were significant with all chemicals tested. The lowest concentrations of these chemicals to induce measurable vtg expression, with significant difference from respective controls, were 17-ethynylestradiol, 2.2ngL(-1); para-nonylphenol, 13.9gL(-1); 17-estradiol, 42.7ngL(-1); and estrone, 46.7ngL(-1), measured as 48-h average concentrations. The present experiments were designed to frame a commonly acceptable approach for investigators who conduct static, in-laboratory proxy environmental aquatic exposures. The present study highlights the need for investigators to report in peer-reviewed submissions the observed concentration values for minimal induction levels when measuring molecular responses to chemical exposures by means of real-time polymerase chain reaction, quantitative polymerase chain reaction, or other omic technologies. Environ Toxicol Chem 2015;34:2796-2802. Published 2015 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US Government work and is in the public domain in the United States of America. C1 [Reddy, Tirumuru V.; Flick, Robert; Lazorchak, James M.; Lattier, David L.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Smith, Mark E.; Wiechman, Barry] US Environm Protect Agcy, Dynamac, Cincinnati, OH USA. RP Lattier, DL (reprint author), US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. EM lattier.david@epa.gov OI Lazorchak, James/0000-0002-7354-7571 NR 51 TC 0 Z9 0 U1 4 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2015 VL 34 IS 12 BP 2796 EP 2802 DI 10.1002/etc.3121 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CX3VQ UT WOS:000365628000018 PM 26088724 ER PT J AU Belanger, SE Sanderson, H Embry, MR Coady, K DeZwart, D Farr, BA Gutsell, S Halder, M Sternberg, R Wilson, P AF Belanger, Scott E. Sanderson, Hans Embry, Michelle R. Coady, Katie DeZwart, Dick Farr, Brianna A. Gutsell, Steve Halder, Marlies Sternberg, Robin Wilson, Peter TI It is time to develop ecological thresholds of toxicological concern to assist environmental hazard assessment SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Threshold of toxicological concern (TTC); Risk assessment; Animal alternatives ID CONCERN TTC; TOXICITY; POLLUTANTS; SUBSTANCES; MODES AB The threshold of toxicological concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints, including carcinogenicity, teratogenicity, and reproductive toxicity. The TTC establishes an exposure level for chemicals below which no appreciable risk to human health or the environment is expected, based on a de minimis value for toxicity identified for many chemicals. Threshold of toxicological concern approaches have benefits for screening-level risk assessments, including the potential for rapid decision-making, fully utilizing existing knowledge, reasonable conservativeness for chemicals used in lower volumes (low production volume chemicals (e.g., < 1 t/yr), and reduction or elimination of unnecessary animal tests. Higher production volume chemicals (>1 t/yr) would in principle always require specific information because of the presumed higher exposure potential. The TTC approach has found particular favor in the assessment of chemicals used in cosmetics and personal care products, as well as other chemicals traditionally used in low volumes. Use of the TTC in environmental safety is just beginning, and initial attempts are being published. Key questions focus on hazard extrapolation of diverse taxa across trophic levels, importance of mode of action, and whether safe concentrations for ecosystems estimated from acute or chronic toxicity data are equally useful and in what contexts. The present study provides an overview of the theoretical basis for developing an ecological (eco)-TTC, with an initial exploration of chemical assessment and boundary conditions for use. An international collaboration under the International Life Sciences Institute Health and Environmental Sciences Institute has been established to address challenges related to developing and applying useful eco-TTC concepts. Environ Toxicol Chem 2015;34:2864-2869. (c) 2015 SETAC C1 [Belanger, Scott E.] Procter & Gamble, Cincinnati, OH USA. [Sanderson, Hans] Aarhus Univ, Roskilde, Denmark. [Embry, Michelle R.; Farr, Brianna A.] Int Life Sci Inst, Hlth & Environm Sci Inst, Washington, DC USA. [Coady, Katie] Dow Chem Co USA, Midland, MI 48674 USA. [DeZwart, Dick] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Gutsell, Steve] Unilever, Sharnbrook, Beds, England. [Halder, Marlies] Commiss European Communities, Joint Res Ctr, I-21020 Ispra, Italy. [Sternberg, Robin] US EPA, Washington, DC 20460 USA. [Wilson, Peter] Sanofi, Bridgewater, NJ USA. RP Embry, MR (reprint author), Int Life Sci Inst, Hlth & Environm Sci Inst, Washington, DC USA. EM membry@hesiglobal.org OI Belanger, Scott/0000-0003-0369-9673 FU SOLUTIONS project via the European Union's Seventh Framework Programme [603437] FX D. de Zwart received funding from the SOLUTIONS project via the European Union's Seventh Framework Programme for research, technological development, and demonstration under grant agreement no. 603437. The authors thank the collaborators on this Health and Environmental Sciences Institute project for valuable input and discussions: A. Beasley, R. Hummel, A. Kienzler, and J. Suski. NR 17 TC 3 Z9 3 U1 2 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2015 VL 34 IS 12 BP 2864 EP 2869 DI 10.1002/etc.3132 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CX3VQ UT WOS:000365628000026 PM 26111584 ER PT J AU Qiu, XZ Zhu, Y Jang, C Lin, CJ Wang, SX Fu, J Xie, JP Wang, JD Ding, DA Long, SC AF Qiu, Xuezhen Zhu, Yun Jang, Carey Lin, Che-Jen Wang, Shuxiao Fu, Joshua Xie, Junping Wang, Jiandong Ding, Dian Long, Shicheng TI Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control SO FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING LA English DT Article DE air quality assessment; human health benefit; economic benefit; air quality attainment assessment; air pollution control strategy; decision support system ID POSTNEONATAL INFANT-MORTALITY; EMERGENCY-DEPARTMENT VISITS; HOSPITAL ADMISSIONS; PARTICULATE MATTER; RESPIRATORY SYMPTOMS; METROPOLITAN-AREAS; AMERICAN CHILDREN; UNITED-STATES; PM2.5; ASTHMA AB Efficient air quality management is critical to protect public health from the adverse impacts of air pollution. To evaluate the effectiveness of air pollution control strategies, the US Environmental Protection Agency (US EPA) has developed the Software for Model Attainment Test-Community Edition (SMAT-CE) to assess the air quality attainment of emission reductions, and the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE) to evaluate the health and economic benefits of air quality improvement respectively. Since scientific decision-making requires timely and coherent information, developing the linkage between SMAT-CE and BenMAP-CE into an integrated assessment platform is desirable. To address this need, a new module linking SMAT-CE to BenMAP-CE has been developed and tested. The new module streamlines the assessment of air quality and human health benefits for a proposed air pollution control strategy. It also implements an optimized data gridding algorithm which significantly enhances the computational efficiency without compromising accuracy. The performance of the integrated software package is demonstrated through a case study that evaluates the air quality and associated economic benefits of a national-level control strategy of PM2.5. The results of the case study show that the proposed emission reduction reduces the number of nonattainment sites from 379 to 25 based on the US National Ambient Air Quality Standards, leading to more than US$334 billion of economic benefits annually from improved public health. The integration of the science-based software tools in this study enhances the efficiency of developing effective and optimized emission control strategies for policy makers. C1 [Qiu, Xuezhen; Zhu, Yun; Lin, Che-Jen; Xie, Junping; Ding, Dian; Long, Shicheng] S China Univ Technol, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou Higher Educ Mega Ctr, Guangzhou 510006, Guangdong, Peoples R China. [Jang, Carey] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Lin, Che-Jen] Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA. [Wang, Shuxiao; Wang, Jiandong] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. [Fu, Joshua] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA. RP Zhu, Y (reprint author), S China Univ Technol, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou Higher Educ Mega Ctr, Guangzhou 510006, Guangdong, Peoples R China. EM zhuyun@scut.edu.cn RI wang, shuxiao/H-5990-2011; Lin, Che-Jen/K-1808-2013; Wang, Jiandong/O-1863-2015 OI wang, shuxiao/0000-0001-9727-1963; Lin, Che-Jen/0000-0001-5990-3093; Wang, Jiandong/0000-0003-3000-622X FU US Environmental Protection Agency [A14-0568-S001]; Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control [2011A060901011]; project of Atmospheric Haze Collaboration Control Technology Design from Chinese Academy of Sciences [XDB05030400]; National Environmental Protection Public Welfare Industry Targeted Research Foundation of China [201409019] FX Financial support and data source for this work is provided by the US Environmental Protection Agency (Subcontract No. A14-0568-S001). This work is also partly supported by the funding of Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control (No. 2011A060901011), the project of Atmospheric Haze Collaboration Control Technology Design (No. XDB05030400) from Chinese Academy of Sciences and the National Environmental Protection Public Welfare Industry Targeted Research Foundation of China (No. 201409019). NR 38 TC 3 Z9 3 U1 5 U2 28 PU HIGHER EDUCATION PRESS PI BEIJING PA NO 4 DEWAI DAJIE, BEIJING 100120, PEOPLES R CHINA SN 2095-2201 EI 2095-221X J9 FRONT ENV SCI ENG JI Front. Env. Sci. Eng. PD DEC PY 2015 VL 9 IS 6 BP 1056 EP 1065 DI 10.1007/s11783-015-0796-8 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CW9HI UT WOS:000365309400012 ER PT J AU O'Leary, TJ Dominitz, JA Chang, KM AF O'Leary, Timothy J. Dominitz, Jason A. Chang, Kyong-Mi TI Veterans Affairs Office of Research and Development: Research Programs and Emerging Opportunities in Digestive Diseases Research SO GASTROENTEROLOGY LA English DT Editorial Material ID MILITARY SERVICE MEMBERS; CARE CLINICAL-TRIAL; COLORECTAL-CANCER; UNITED-STATES; MILLENNIUM COHORT; MENTAL-HEALTH; HEPATITIS; RISK; PREVALENCE; DEPLOYMENT C1 [O'Leary, Timothy J.] US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20460 USA. [Dominitz, Jason A.] VA Puget Sound Hlth Care Syst, Dept Vet Affairs, Seattle, WA USA. [Dominitz, Jason A.] Univ Washington, Sch Med, Seattle, WA USA. [Chang, Kyong-Mi] Univ Penn, Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA 19104 USA. [Chang, Kyong-Mi] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. RP O'Leary, TJ (reprint author), US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20460 USA. FU BLRD VA [I01 BX000649]; Intramural VA [VA999999] NR 24 TC 3 Z9 3 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 2015 VL 149 IS 7 BP 1652 EP 1661 DI 10.1053/j.gastro.2015.10.021 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CX6JX UT WOS:000365808100011 PM 26526712 ER PT J AU Lytle, DA Williams, D Muhlen, C Pham, M Kelty, K Wildman, M Lang, G Wilcox, M Kohne, M AF Lytle, Darren A. Williams, Dan Muhlen, Christy Pham, Maily Kelty, Keith Wildman, Matthew Lang, Glenn Wilcox, Mitch Kohne, Melissa TI The Full-Scale Implementation of an Innovative Biological Ammonia Treatment Process SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Editorial Material C1 [Lytle, Darren A.] US EPA, Off Res & Dev, Water Supply & Water Resources Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Lytle, DA (reprint author), US EPA, Off Res & Dev, Water Supply & Water Resources Div, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM lytle.darren@epa.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD DEC PY 2015 VL 107 IS 12 BP 71 EP 71 DI 10.5942/jawwa.2015.107.0176 PG 1 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CX1NE UT WOS:000365462100011 ER PT J AU Thai, SF Wallace, KA Jones, CP Ren, H Castellon, BT Crooks, J Grulke, EA Kitchin, KT AF Thai, Sheau-Fung Wallace, Kathleen A. Jones, Carlton P. Ren, Hongzu Castellon, Benjamin T. Crooks, James Grulke, Eric A. Kitchin, Kirk T. TI Differential Genomic Effects on Signaling Pathways by Two Different CeO2 Nanoparticles in HepG2 Cells SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE Nanoparticle; Nanomaterial; Nano CeO2; mRNA Profiling; Signaling Pathways; Warburg Effect ID CERIUM OXIDE NANOPARTICLES; TITANIUM-DIOXIDE NANOPARTICLES; OXIDATIVE STRESS; BEAS-2B CELLS; TOXICITY; LUNG; ACTIVATION; PARTICLES; SILVER; TIO2 AB To investigate genomic effects, human liver hepatocellular carcinoma (HepG2) cells were exposed for three days to two different forms of nanoparticles both composed of CeO2 (0.3, 3 and 30 mu g/mL). The two CeO2 nanoparticles had dry primary particle sizes of 8 nanometers {(M) made by NanoAmor} and 58 nanometers {(L) made by Alfa Aesar} and differ in various other physical-chemical properties as well. The smaller particle has stronger antioxidant properties, probably because it has higher Ce3+ levels on the particle surface, as well as more surface area per unit weight. Nanoparticle M showed a normal dose-response pattern with 363, 633 and 1273 differentially expressed genes (DEGs) at 0.3, 3 and 30 mu g/mL, respectively. In contrast, nanoparticle L showed a puzzling dose-response pattern with the most DEGs found in the lowest exposure group with 1049, 303 and 323 DEGs at 0.3, 3 and 30 mu g/mL, respectively. This systems biological genomic study showed that the major altered pathways by these two nano cerium oxides were protein synthesis, stress response, proliferation/cell cycle, cytoskeleton remodeling/actin polymerization and cellular metabolism. Some of the canonical pathways affected were mTOR signaling, EIF2 signaling, fatty acid activation, G2/M DNA damage checkpoint regulation, glycolysis and protein ubiquitination. These two CeO2 nanoparticles differed considerably in their genomic effects. M is more active than L in respect to altering the pathways of mitochondrial dysfunction, acute phase response, apoptosis, 14-3-3 mediated signaling, remodeling of epithelial adherens junction signaling, actin nucleation by ARP-WASP complex, altered TCA cycle and elevated fatty acid concentrations by metabolomics. However, L is more active than M in respect to the pathways of NRF2-mediated stress response and hepatic fibrosis/hepatic stellate cell activation. One major difference in the cell response to nano M and L is that nano M caused the Warburg effect while nano L did not. C1 [Thai, Sheau-Fung; Wallace, Kathleen A.; Jones, Carlton P.; Ren, Hongzu; Castellon, Benjamin T.; Crooks, James; Kitchin, Kirk T.] US EPA, Res Triangle Pk, NC 27711 USA. [Grulke, Eric A.] Univ Kentucky, Chem & Mat Engn, Lexington, KY 40506 USA. RP Thai, SF (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. RI Castellon, Benjamin/I-4117-2014 OI Castellon, Benjamin/0000-0001-8883-076X NR 36 TC 2 Z9 2 U1 7 U2 26 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1533-4880 EI 1533-4899 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD DEC PY 2015 VL 15 IS 12 BP 9925 EP 9937 DI 10.1166/jnn.2015.11631 PG 13 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CX2VN UT WOS:000365555000084 PM 26682436 ER PT J AU Gordon, SM McKenzie, B Kemeh, G Sampson, M Perl, S Young, NS Fessler, MB Remaley, AT AF Gordon, Scott M. McKenzie, Benjamin Kemeh, Georgina Sampson, Maureen Perl, Shira Young, Neal S. Fessler, Michael B. Remaley, Alan T. TI Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID 2-DIMENSIONAL GEL-ELECTROPHORESIS; INDUCED PULMONARY-EMPHYSEMA; NEUTROPHIL ELASTASE; MASS-SPECTROMETRY; CHOLESTEROL; STATINS; ALPHA(1)-ANTITRYPSIN; MACROPHAGES; PROTEINS; THERAPY AB Statins lower plasma cholesterol by as much as 50%, thus reducing future cardiovascular events. However, the physiological effects of statins are diverse and not all are related to low density lipoprotein cholesterol (LDL-C) lowering. We performed a small clinical pilot study to assess the impact of statins on lipoprotein-associated proteins in healthy individuals (n = 10) with normal LDL-C (<130 mg/dL), who were treated with rosuvastatin (20 mg/day) for 28 days. Proteomic analysis of size-exclusion chromatography isolated LDL, large high density lipoprotein (HDL-L), and small HDL (HDL-S) fractions and spectral counting was used to compare relative protein detection before and after statin therapy. Significant protein changes were found in each lipoprotein pool and included both increases and decreases in several proteins involved in lipoprotein metabolism, complement regulation and acute phase response. The most dramatic effect of the rosuvastatin treatment was an increase in alpha-1-antirypsin (A1AT) spectral counts associated with HDL-L particles. Quantitative measurement by ELISA confirmed an average 5.7-fold increase in HDL-L associated A1AT. Molecular modeling predictions indicated that the hydrophobic reactive center loop of A1AT, the functional domain responsible for its protease inhibitor activity, is likely involved in lipid binding and association with HDL was found to protect A1AT against oxidative inactivation. Cell culture experiments, using J774 macrophages, demonstrated that the association of A1AT with HDL enhances its antiprotease activity, preventing elastase induced production of tumor necrosis factor . In conclusion, we show that statins can significantly alter the protein composition of both LDL and HDL and our studies reveal a novel functional relationship between A1AT and HDL. The up-regulation of A1AT on HDL enhances its anti-inflammatory functionality, which may contribute to the non-lipid lowering beneficial effects of statins. C1 [Gordon, Scott M.; McKenzie, Benjamin; Kemeh, Georgina; Sampson, Maureen; Remaley, Alan T.] NHLBI, Lipoprotein Metab Sect, NIH, Bethesda, MD 20892 USA. [Perl, Shira; Young, Neal S.] NHLBI, Cell Biol Sect, NIH, Bethesda, MD 20892 USA. [Fessler, Michael B.] Natl Inst Environm Hlth Sci, Inflammat & Dis Lab, Immun, NIH, Res Triangle Pk, NC USA. RP Gordon, SM (reprint author), NHLBI, Lipoprotein Metab Sect, 9000 Rockville Pike,Bldg 10 Room 8N224, Bethesda, MD 20892 USA. EM scott.gordon@nih.gov FU National Institutes of Health, National Heart Lung and Blood Institute FX This work was supported by the National Institutes of Health, National Heart Lung and Blood Institute. Intramural Research Program. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 41 TC 4 Z9 4 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 EI 1535-9484 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD DEC PY 2015 VL 14 IS 12 BP 3247 EP 3257 DI 10.1074/mcp.M115.054031 PG 11 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA CX3ZN UT WOS:000365638100012 PM 26483418 ER PT J AU Remick, AK Catlin, NR Quist, EM Steinbach, TJ Dixon, D AF Remick, Amera K. Catlin, Natasha R. Quist, Erin M. Steinbach, Thomas J. Dixon, Darlene TI Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists SO TOXICOLOGIC PATHOLOGY LA English DT Article DE developmental pathology; pediatrics; pharmaceutical development; products; preclinical safety assessment; risk management; toxicologic pathology; drug development ID PEDIATRIC DRUG DEVELOPMENT; NONHUMAN-PRIMATES; DEVELOPMENTAL TOXICITY; BISPHENOL-A; NEUROENDOCRINE PARAMETERS; POSTNATAL-DEVELOPMENT; REPRODUCTIVE-SYSTEM; IMMUNE-RESPONSES; MACACA-MULATTA; NERVOUS-SYSTEM AB The Society of Toxicologic Pathology (STP) Education Committee and the STP Reproductive Special Interest Group held a North Carolina regional meeting entitled, Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists on March 13, 2015, at the National Institute of Environmental Health Sciences/National Toxicology Program in Research Triangle Park, North Carolina. The purpose of this regional meeting was to familiarize attendees with the topic of juvenile toxicity testing and discuss its relevance to clinical pediatric medicine, regulatory perspectives, challenges of appropriate study design confronted by toxicologists, and challenges of histopathologic examination and interpretation of juvenile tissues faced by pathologists. The 1-day meeting was a success with over 60 attendees representing industry, government, research organizations, and academia. C1 [Remick, Amera K.] WIL Res, Hillsborough, NC USA. [Catlin, Natasha R.] Natl Inst Environm Hlth Sci, Toxicol Branch, Dev & Reprod Toxicol Grp, Natl Toxicol Program NTP Div, Res Triangle Pk, NC USA. [Quist, Erin M.] Natl Inst Environm Hlth Sci, Reprod Endocrinol Grp, NTPL, Res Triangle Pk, NC USA. [Quist, Erin M.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, NTP Div, NTP Pathol Grp, Res Triangle Pk, NC USA. [Steinbach, Thomas J.] Expt Pathol Labs Inc, Durham, NC USA. [Dixon, Darlene] Natl Inst Environm Hlth Sci, Mol Pathogenesis Grp, NTPL, Res Triangle Pk, NC USA. RP Remick, AK (reprint author), WIL Res Pathol, 310 Millstone Dr, Hillsborough, NC 27278 USA. EM amera.remick@wilresearch.com FU Intramural NIH HHS [ZIA ES021196-16, Z01 ES021196-15] NR 72 TC 0 Z9 0 U1 1 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-6233 EI 1533-1601 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD DEC PY 2015 VL 43 IS 8 BP 1166 EP 1171 DI 10.1177/0192623315595883 PG 6 WC Pathology; Toxicology SC Pathology; Toxicology GA CX5JT UT WOS:000365738600013 PM 26220944 ER PT J AU Knudsen, GA Hughes, MF McIntosh, KL Sanders, JM Birnbaum, LS AF Knudsen, Gabriel A. Hughes, Michael F. McIntosh, Katelyn L. Sanders, J. Michael Birnbaum, Linda S. TI Estimation of tetrabromobisphenol A (TBBPA) percutaneous uptake in humans using the parallelogram method SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Dermal bioavailability; Brominated flame retardant; Tetrabromobisphenol A; Parallelogram method; Persistent organic pollutant ID VITRO DERMAL ABSORPTION; SPRAGUE-DAWLEY RATS; IN-VITRO; FLAME RETARDANTS; BISPHENOL-A; HOUSE-DUST; EXPOSURE; SKIN; DISPOSITION; VIVO AB Tetrabromobisphenol A (TBBPA) is currently the world's highest production volume brominated flame retardant. Humans are frequently exposed to TBBPA by the dermal route. In the present study, a parallelogram approach was used to make predictions of internal dose in exposed humans. Human and rat skin samples received 100 nmol of TBBPA/cm(2) skin and absorption and penetrance were determined using a flow-through in vitro system. TBBPA-derived [C-14]-radioactivity was determined at 6 h intervals in the media and at 24 h post-dosing in the skin. The human skin and media contained an average of 3.4% and 0.2% of the total dose at the terminal time point respectively, while the rat skin and media contained 9.3% and 3.5%, respectively. In the intact rat, 14% of a dermally-administered dose of similar to 100 nmol/cm(2) remained in the skin at the dosing site, with an additional 8% reaching systemic circulation by 24 h post-dosing. Relative absorption and penetrance were less (10% total) at 24 h following dermal administration of a ten-fold higher dose (similar to 1000 nmol/cm(2)) to rats. However, by 72 h, 70% of this dose was either absorbed into the dosing-site skin or had reached systemic circulation. It is clear from these results that TBBPA can be absorbed by the skin and dermal contact with TBBPA may represent a small but important route of exposure. Together, these in vitro data in human and rat skin and in vivo data from rats may be used to predict TBBPA absorption in humans following dermal exposure. Based on this parallelogram calculation, up to 6% of dermally applied TBBPA may be bioavailable to humans exposed to TBBPA. Published by Elsevier Inc. C1 [Knudsen, Gabriel A.; McIntosh, Katelyn L.; Sanders, J. Michael; Birnbaum, Linda S.] NIEHS, NCI, Res Triangle Pk, NC 27709 USA. [Hughes, Michael F.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Knudsen, GA (reprint author), 111 T W Alexander Dr,BG 101 C202A, Res Triangle Pk, NC 27709 USA. EM gabriel.knudsen@nih.gov OI Knudsen, Gabriel/0000-0002-7208-6451 FU NIH/NCI [ZIA BC 011476] FX The authors would like to thank Ms. Brenda Edwards, Mr. Vivek Miyani, Mr. Rohil Chekuri, Mr. Ethan Hull, and Mr. Abdella Sadik for technical assistance. This article has been reviewed in accordance with the policy of the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This research was supported in part by the Intramural Research Program of NIH/NCI (ZIA BC 011476). NR 49 TC 1 Z9 1 U1 3 U2 19 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD DEC 1 PY 2015 VL 289 IS 2 BP 323 EP 329 DI 10.1016/j.taap.2015.09.012 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CX1NC UT WOS:000365461900019 PM 26387765 ER PT J AU Spence, PL Walker, JT Robarge, WP Preston, B Osmond, DL AF Spence, Porche L. Walker, John T. Robarge, Wayne P. Preston, Bill Osmond, Deanna L. TI Comparing nitrous oxide losses from three residential landscapes under different management schemes following natural rainfall events SO URBAN ECOSYSTEMS LA English DT Article DE Nitrogen; Lawn maintenance; Fertilizer inputs; Greenhouse gas; Turfgrass; Flux; Measurements; Rainfall ID FILLED PORE-SPACE; CHAMBER MEASUREMENTS; SOIL; FLUXES; DENITRIFICATION; EMISSIONS; ATMOSPHERE; FERTILIZER; TURFGRASS; NITRIFICATION AB Lawn management practices that produce aesthetically appealing landscapes may also create environmental conditions that stimulate soil nitrous oxide (N2O) fluxes. The purpose of this exploratory study is to investigate the effects of lawn management practices on N2O fluxes from three non-replicated distinctly different residential landscapes: a high maintenance fescue (Festuca arundinacea) lawn (HMFL), a low maintenance fescue lawn (LMFL), and a mixed hardwood forested residential landscape (FRL) located in Cary, North Carolina. The specific objectives are (1) to measure the N2O fluxes from three residential landscapes within a fixed 24-h period following natural rainfall events; and (2) to determine the effect of lawn maintenance, season, water filled pore space (WFPS%), temperature, and days after fertilization on N2O flux. The mean N2O fluxes for HMFL (14.3 +/- 2.28 mu g N2O-N m(-2) h(-1)), LMFL (3.14 +/- 0.68 mu g N2O-N m(-2) h(-1)) and FRL (0.43 +/- 0.08 mu g N2O-N m(-2) h(-1)) indicate that residential lawns receiving the recommended amount of fertilizer and frequent irrigation exhibit higher N2O fluxes than non-irrigated fertilized lawns or forested landscapes. Patterns of N2O fluxes from the HMFL and LMFL were associated with timing of fertilizer applications, presence or absence of irrigation, and seasonal fescue growth patterns. For the FRL, lower N inputs and the presence of a decomposing litter layer potentially limited N2O production. Our findings suggest that lawn management practices (i.e., fertilizer applications and irrigation) can create differences in the N2O flux following natural rainfall events. C1 [Spence, Porche L.; Robarge, Wayne P.; Osmond, Deanna L.] N Carolina State Univ, Dept Soil Sci, Raleigh, NC 27695 USA. [Walker, John T.] US EPA, Res Triangle Pk, NC 27711 USA. [Preston, Bill] Arcadis US Inc, Durham, NC 27713 USA. RP Spence, PL (reprint author), N Carolina State Univ, Dept Soil Sci, 100 Derieux St,Williams Hall,POB 7619, Raleigh, NC 27695 USA. EM porchespence@yahoo.com NR 47 TC 0 Z9 0 U1 6 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1083-8155 EI 1573-1642 J9 URBAN ECOSYST JI Urban Ecosyst. PD DEC PY 2015 VL 18 IS 4 BP 1227 EP 1243 DI 10.1007/s11252-015-0453-9 PG 17 WC Biodiversity Conservation; Ecology; Environmental Sciences; Urban Studies SC Biodiversity & Conservation; Environmental Sciences & Ecology; Urban Studies GA CX6NK UT WOS:000365817600011 ER PT J AU Alexander, LC AF Alexander, Laurie C. TI Science at the boundaries: scientific support for the Clean Water Rule SO FRESHWATER SCIENCE LA English DT Article DE Clean Water Act; Clean Water Rule; science synthesis; science-policy interface; streams; wetlands; connectivity ID ISOLATED WETLANDS; CONNECTIVITY; LIDAR AB The US Environmental Protection Agency (EPA) and US Army Corps of Engineers have promulgated a definitional rule to clarify the scope of "waters of the United States" protected under the Clean Water Act (CWA). The Clean Water Rule, published in June 2015, defines 8 categories of waters for jurisdiction and expressly excludes certain features from jurisdiction, based on law, science, public input, and 40+ y of experience implementing the CWA. It also defines terms used in regulation including, for the first time, "tributary," "neighboring," and "significant nexus". Much of the scientific basis for this rule is contained in a report titled "Connectivity of Streams and Wetlands to Downstream Waters: A Review and Synthesis of the Scientific Evidence" developed by EPA's Office of Research and Development to inform the rulemaking process. As a scientific review, the report does not consider or set forth legal standards for CWA jurisdiction. Rather, it summarizes current scientific understanding of the connections and functions by which small or temporary streams, nontidal wetlands, and other source waters, singly or in aggregate, exert a strong influence on the chemical, physical, or biological integrity of waters protected by the CWA. It is the result of a multiyear collaboration by scientists and nonscientists working across disciplinary and organizational boundaries to synthesize the best available science in response to evolving policy needs. Here I summarize the major conclusions from the report, the influence of science on policy decisions in the final rule, and some challenges of synthesizing, interpreting, reviewing, and communicating the large body of scientific evidence needed for development of this rule. C1 [Alexander, Laurie C.] US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Alexander, LC (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA. EM alexander.laurie@epa.gov NR 18 TC 4 Z9 4 U1 8 U2 28 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD DEC PY 2015 VL 34 IS 4 BP 1588 EP 1594 DI 10.1086/684076 PG 7 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CW2IM UT WOS:000364815000031 ER PT J AU Jones, SE Doroski, B Glick, S AF Jones, Sherry Everett Doroski, Brenda Glick, Sherry TI Association Between State Assistance on the Topic of Indoor Air Quality and School District-Level Policies That Promote Indoor Air Quality in Schools SO JOURNAL OF SCHOOL NURSING LA English DT Article DE environmental health; safety; policies; procedures; safety; injury prevention; best practices; practice guidelines AB Nationally representative data from the 2012 School Health Policies and Practices Study examined whether state assistance on indoor air quality (IAQ) was associated with district-level policies and practices related to IAQ and integrated pest management (IPM). Districts in states that provided assistance on IAQ were more likely than districts not in such states to (1) have an IAQ management program (p < .001); (2) require schools to conduct periodic inspections of the heating, ventilation, and air conditioning system (p < .05); of the building for cracks, leaks, or past water damage (p < .01); for mold (p < .01); for clutter that prevents effective cleaning and maintenance (p < .05); of the plumbing system (p < .01); and for condensation in and around school facilities (p < .001); (3) have an engine idling reduction program ( < .001); (4) have a policy to purchase low-emitting products (p < .05); and (5) require IPM strategies (p < .05). Increasing the number of states that provide IAQ-related assistance to school districts and schools may improve school IAQ. C1 [Jones, Sherry Everett] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30329 USA. [Doroski, Brenda] US EPA, Indoor Envirom Div, Washington, DC 20460 USA. [Glick, Sherry] US EPA, Off Pesticide Programs, Dallas, TX USA. RP Jones, SE (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E75, Atlanta, GA 30329 USA. EM sce2@cdc.gov NR 30 TC 1 Z9 1 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1059-8405 EI 1546-8364 J9 J SCH NURS JI J. Sch. Nurs. PD DEC PY 2015 VL 31 IS 6 BP 422 EP 429 DI 10.1177/1059840515579082 PG 8 WC Nursing SC Nursing GA CW4MK UT WOS:000364965400006 ER PT J AU Ramos, RL Van Dine, SE Gilbert, ME Leheste, JR Torres, G AF Ramos, Raddy L. Van Dine, Sarah E. Gilbert, Mary E. Leheste, Joerg R. Torres, German TI Neurodevelopmental Malformations of the Cerebellar Vermis in Genetically Engineered Rats SO CEREBELLUM LA English DT Article DE Vermis; Malformation; Heterotopia; Neuronal migration ID AMYOTROPHIC-LATERAL-SCLEROSIS; HUNTINGTONS-DISEASE; GENE KNOCKOUT; FISSURA PRIMA; STEM-CELLS; MODEL; CYTOARCHITECTURE; TOOLS; MICE AB The cerebellar vermis is particularly vulnerable to neurodevelopmental malformations in humans and rodents. Sprague-Dawley, and Long-Evans rats exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the vermis. Malformations are almost exclusively found along the primary fissure and are indicative of deficits of neuronal migration during cerebellar development. In the present report, we test the prediction that genetically engineered rats on Sprague-Dawley or Long-Evans backgrounds will also exhibit the same cerebellar malformations. Consistent with our hypothesis, we found that three different transgenic lines on two different backgrounds had cerebellar malformations. Heterotopia in transgenic rats had identical cytoarchitecture as that observed in wild-type rats including altered morphology of Bergmann glia. In light of the possibility that heterotopia could affect results from behavioral studies, these data suggest that histological analyses be performed in studies of cerebellar function or development when using genetically engineered rats on these backgrounds in order to have more careful interpretation of experimental findings. C1 [Ramos, Raddy L.; Van Dine, Sarah E.; Leheste, Joerg R.; Torres, German] New York Inst Technol, Dept Biomed Sci, Coll Osteopath Med, Old Westbury, NY 11568 USA. [Gilbert, Mary E.] US EPA, Toxic Assessment Div, Neurotoxicol Branch, Durham, NC USA. RP Ramos, RL (reprint author), New York Inst Technol, Dept Biomed Sci, Coll Osteopath Med, Northern Blvd,POB 8000, Old Westbury, NY 11568 USA. EM rramos02@nyit.edu NR 30 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1473-4222 EI 1473-4230 J9 CEREBELLUM JI Cerebellum PD DEC PY 2015 VL 14 IS 6 BP 624 EP 631 DI 10.1007/s12311-015-0657-9 PG 8 WC Neurosciences SC Neurosciences & Neurology GA CV8ZL UT WOS:000364576900002 PM 25700682 ER PT J AU Angelon-Gaetz, KA Richardson, DB Lipton, DM Marshall, SW Lamb, B LoFrese, T AF Angelon-Gaetz, K. A. Richardson, D. B. Lipton, D. M. Marshall, S. W. Lamb, B. LoFrese, T. TI The effects of building-related factors on classroom relative humidity among North Carolina schools participating in the "Free to Breathe, Free to Teach' study SO INDOOR AIR LA English DT Article DE Indoor air quality; Relative humidity; Schools; Classrooms; Building-related factors; Longitudinal study ID INDOOR AIR-QUALITY; MOLD GROWTH; TEMPERATURE; SYMPTOMS; MOISTURE; DAMPNESS; ASTHMA; ASSOCIATION; ADOLESCENTS; CHILDREN AB Both high and low indoor relative humidity (RH) directly impact Indoor Air Quality (IAQ), an important school health concern. Prior school studies reported a high prevalence of mold, roaches, and water damage; however, few examined associations between modifiable classroom factors and RH, a quantitative indicator of dampness. We recorded RH longitudinally in 134 North Carolina classrooms (n=9066 classroom-days) to quantify the relationships between modifiable classroom factors and average daily RH below, within, or above levels recommended to improve school IAQ (30-50% or 30-60% RH). The odds of having high RH (>60%) were 5.8 [95% Confidence Interval (CI): 2.9, 11.3] times higher in classrooms with annual compared to quarterly heating, ventilating, and air-conditioning (HVAC) system maintenance and 2.5 (95% CI: 1.5, 4.2) times higher in classrooms with HVAC economizers compared to those without economizers. Classrooms with direct-expansion split systems compared to chilled water systems had 2.7 (95% CI: 1.7, 4.4) times higher odds of low RH (<30%). When unoccupied, classrooms with thermostat setbacks had 3.7 (95% CI: 1.7, 8.3) times the odds of high RH (>60%) of those without setbacks. This research suggests actionable decision points for school design and maintenance to prevent high or low classroom RH. C1 [Angelon-Gaetz, K. A.; Richardson, D. B.; Marshall, S. W.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Lipton, D. M.] Dept Hlth & Human Serv, North Carolina Div Publ Hlth, Raleigh, NC USA. [Lamb, B.] New Hanover Cty Sch, Maintenance Operat Dept, Wilmington, NC USA. [LoFrese, T.] Chapel Hill Carrboro City Sch, Support Serv, Chapel Hill, NC USA. RP Angelon-Gaetz, KA (reprint author), US EPA, ORISE Res Participat Program, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM kangelongaetz@gmail.com OI Gaetz, Kim/0000-0002-8530-0066; Marshall, Stephen/0000-0002-2664-9233 FU National Institute of Environmental Health Sciences through the Center for Environmental Health and Susceptibility (CEHS), University of North Carolina (UNC)-Chapel Hill [P30ES010126]; North Carolina Translational and Clinical Sciences Institute (NC TraCs) 10K Pilot Project from the National Center for Research Resources [UL1RR025747]; National Institute of Occupational Safety and Health (NIOSH) Training Grant; Environmental Protection Agency (EPA) Science to Achieve Results (STAR) Fellowship; NC Public Health Association (NCPHA) Scholarship FX This research was supported in part by a grant from the National Institute of Environmental Health Sciences (P30ES010126) through the Center for Environmental Health and Susceptibility (CEHS), University of North Carolina (UNC)-Chapel Hill; by the North Carolina Translational and Clinical Sciences Institute (NC TraCs) 10K Pilot Project Award Number UL1RR025747 from the National Center for Research Resources; the National Institute of Occupational Safety and Health (NIOSH) Training Grant; the Environmental Protection Agency (EPA) Science to Achieve Results (STAR) Fellowship; and the NC Public Health Association (NCPHA) Scholarship. Karin Yeatts was integral to the project design and implementation. Jenna Hargens and Bryce Koukopoulos assisted with data collection and study site management. Chris Wiesen assisted with SAS programming. Bill Kelley and Romie Herring provided mechanical advice and assisted with walkthrough inspections. Steve Wing advised us on the data analysis, conceptual framework, and study design. We would also like to thank our research participants and other school community members who made this study possible. This research was conducted by Kim Angelon-Gaetz, for completion of her doctoral work at the University of North Carolina at Chapel Hill. The views expressed by here do not necessarily reflect those of the U.S. Environmental Protection Agency. Mention of trade names, products, or services does not convey official EPA approval, endorsement, or recommendation. NR 42 TC 3 Z9 3 U1 5 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0905-6947 EI 1600-0668 J9 INDOOR AIR JI Indoor Air PD DEC PY 2015 VL 25 IS 6 BP 620 EP 630 DI 10.1111/ina.12176 PG 11 WC Construction & Building Technology; Engineering, Environmental; Public, Environmental & Occupational Health SC Construction & Building Technology; Engineering; Public, Environmental & Occupational Health GA CW0TZ UT WOS:000364703700006 PM 25515546 ER PT J AU Wickham, J Barnes, CA Nash, MS Wade, TG AF Wickham, J. Barnes, C. A. Nash, M. S. Wade, T. G. TI Combining NLCD and MODIS to create a land cover-albedo database for the continental United States SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Climate change; Land cover change; Landsat; Radiative forcing; Snow-cover albedo; Snow-free albedo ID IN-SITU MEASUREMENTS; SURFACE ALBEDO; ACCURACY ASSESSMENT; REFLECTANCE; PRODUCTS; SNOW; BRDF; COMPLETION; RESOLUTION; CLIMATE AB Land surface albedo is an essential climate variable that is tightly linked to land cover, such that specific land cover classes (e.g., deciduous broadleaf forest, cropland) have characteristic albedos. Despite the normative of land-cover class specific albedos, there is considerable variability in albedo within a land cover class. The National Land Cover Database (NLCD) and the Moderate Resolution Imaging Spectroradiometer (MODIS) albedo product were combined to produce a long-term (14 years) integrated land cover-albedo database for the continental United States that can be used to examine the temporal behavior of albedo as a function of land cover. The integration identifies areas of homogeneous land cover at the nominal spatial resolution of the MODIS (MCD43A) albedo product (500 m x 500 m) from the NLCD product (30 m x 30 m), and provides an albedo data record per 500 m x 500 m pixel for 14 of the 16 NLCD land cover classes. Individual homogeneous land cover pixels have up to 605 albedo observations, and 75% of the pixels have at least 319 MODIS albedo observations (>= 50% of the maximum possible number of observations) for the study period (2000-2013). We demonstrated the utility of the database by conducting a multivariate analysis of variance of albedo for each NLCD land cover class, showing that locational (pixel-to-pixel) and inter-annual variability were significant factors in addition to expected seasonal (intra-annual) and geographic (latitudinal) effects. Published by Elsevier Inc. C1 [Wickham, J.; Wade, T. G.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Barnes, C. A.] ASRC Fed InuTeq LLC, USGS Earth Resources Observat & Sci EROS, Sioux Falls, SD 57198 USA. [Nash, M. S.] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89193 USA. RP Wickham, J (reprint author), US EPA, 109 TW Alexander Dr,MD E243-05, Res Triangle Pk, NC 27711 USA. EM wickham.james@epa.gov FU United States Environmental Protection Agency, through its Office of Research and Development FX The United States Environmental Protection Agency, through its Office of Research and Development, partly funded and managed the research described here. The article has been reviewed by the USEPA's Office of Research and Development and approved for publication. Approval does not signify that the contents reflect the views of the USEPA. C. Barnes' participation was underwritten by contract G13PC00028 between ASRC Federal InuTeq LLC and USGS. The authors are grateful for comments on earlier drafts by Megan Mehaffey (USEPA), Jim Vogelmann (USGS), and 3 anonymous reviewers. Use of trade names does not imply endorsement by the U.S. Government NR 45 TC 2 Z9 2 U1 2 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD DEC 1 PY 2015 VL 170 BP 143 EP 152 DI 10.1016/j.rse.2015.09.012 PG 10 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA CW1CB UT WOS:000364726100013 ER PT J AU Ekenga, CC Parks, CG Sandler, DP AF Ekenga, Christine C. Parks, Christine G. Sandler, Dale P. TI A prospective study of occupational physical activity and breast cancer risk SO CANCER CAUSES & CONTROL LA English DT Article DE Breast cancer; Cohort; Physical activity; Workplace; Women ID POSTMENOPAUSAL WOMEN; PROSPECTIVE COHORT; RECEPTOR STATUS; LEISURE-TIME; BODY-MASS; IN-SITU; NUTRITION; POPULATION; PREMENOPAUSAL; SWEDEN AB Physical activity has been associated with reduced breast cancer risk, but studies of occupational activity have produced inconsistent results. The purpose of this study was to evaluate the relationship between occupational physical activity and breast cancer in a prospective study of women with a family history of breast cancer. We studied breast cancer risk in 47,649 Sister Study participants with an occupational history. Information on occupational activity and breast cancer risk factors was collected during baseline interviews (2004-2009). Physical activity at each job was self-reported and categorized as mostly sitting, sitting and standing equally, mostly standing, and active. Multivariable Cox proportional hazards regression was used to evaluate associations between lifetime occupational activity and incident breast cancer, after adjusting for established risk factors and recreational activity. During follow-up, a total of 1,798 breast cancer diagnoses were reported. Compared with women who did not spend any time in active jobs, women who spent a high proportion (a parts per thousand yen75 %) of their working years in active jobs had a reduced risk of breast cancer (HR 0.72; 95 % CI 0.52-0.98). Associations were strongest among overweight (HR 0.64; 95 % CI 0.42-0.98) and postmenopausal (HR 0.67; 95 % CI 0.45-0.98) women. Occupational activity was associated with a reduced risk of breast cancer. Occupational activity is a domain of physical activity that should be further examined in studies of postmenopausal breast cancer risk. Additional research is necessary to better understand the mechanisms underlying the relationships between occupational activity, body size, and breast cancer. C1 [Ekenga, Christine C.] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA. [Parks, Christine G.; Sandler, Dale P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA. RP Sandler, DP (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA. EM sandler@niehs.nih.gov OI Parks, Christine/0000-0002-5734-3456; Sandler, Dale/0000-0002-6776-0018 FU NIH, National Institute of Environmental Health Sciences [Z01-ES-044005] FX This research was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES-044005). NR 51 TC 5 Z9 5 U1 5 U2 17 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 EI 1573-7225 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD DEC PY 2015 VL 26 IS 12 BP 1779 EP 1789 DI 10.1007/s10552-015-0671-8 PG 11 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA CV0QM UT WOS:000363956100008 PM 26450605 ER PT J AU Garcia, RI Ibrahim, JG Wambaugh, JF Kenyon, EM Setzer, RW AF Garcia, Ramon I. Ibrahim, Joseph G. Wambaugh, John F. Kenyon, Elaina M. Setzer, R. Woodrow TI Identifiability of PBPK models with applications to dimethylarsinic acid exposure SO JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS LA English DT Article DE PBPK Models; Identifiability; Gibbs sampling; Metropolis-Hasting algorithm; Dimethyl arsinic acid ID STRUCTURAL IDENTIFIABILITY; PHARMACOKINETIC MODELS; MONTE-CARLO; SYSTEMS; DISTRIBUTIONS; DISPOSITION; METABOLISM; PARAMETER; SCIENCE; MOUSE AB Any statistical model should be identifiable in order for estimates and tests using it to be meaningful. We consider statistical analysis of physiologically-based pharmacokinetic (PBPK) models in which parameters cannot be estimated precisely from available data, and discuss different types of identifiability that occur in PBPK models and give reasons why they occur. We particularly focus on how the mathematical structure of a PBPK model and lack of appropriate data can lead to statistical models in which it is impossible to estimate at least some parameters precisely. Methods are reviewed which can determine whether a purely linear PBPK model is globally identifiable. We propose a theorem which determines when identifiability at a set of finite and specific values of the mathematical PBPK model (global discete identifiability) implies identifiability of the statistical model. However, we are unable to establish conditions that imply global discrete identifiability, and conclude that the only safe approach to analysis of PBPK models involves Bayesian analysis with truncated priors. Finally, computational issues regarding posterior simulations of PBPK models are discussed. The methodology is very general and can be applied to numerous PBPK models which can be expressed as linear time-invariant systems. A real data set of a PBPK model for exposure to dimethyl arsinic acid (DMA(V)) is presented to illustrate the proposed methodology. C1 [Garcia, Ramon I.; Ibrahim, Joseph G.] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. [Kenyon, Elaina M.] US EPA, Natl Hlth & Environm Effects Lab, Res Triangle Pk, NC 27711 USA. [Wambaugh, John F.; Setzer, R. Woodrow] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Setzer, RW (reprint author), US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. EM setzer.woodrow@epa.gov OI Wambaugh, John/0000-0002-4024-534X FU United States Environmental Protection Agency through Office of Research and Development; United States Environmental Protection Agency, National Center for Computational Toxicology through the Curriculum in Toxicology, University of North Carolina [CR83323710] FX We thank Marina V. Evans for providing technical review of this work. Three anonymous reviewers' comments greatly improved the text, for which we thank them. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. RIG was funded by United States Environmental Protection Agency, National Center for Computational Toxicology through the Curriculum in Toxicology, University of North Carolina under Cooperative Training Program CR83323710. NR 36 TC 2 Z9 2 U1 2 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1567-567X EI 1573-8744 J9 J PHARMACOKINET PHAR JI J. Pharmacokinet. Pharmacodyn. PD DEC PY 2015 VL 42 IS 6 BP 591 EP 609 DI 10.1007/s10928-015-9424-2 PG 19 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CV0ZO UT WOS:000363982800001 PM 26194069 ER PT J AU Brown, RA Borst, M AF Brown, Robert A. Borst, Michael TI Nutrient infiltrate concentrations from three permeable pavement types SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Permeable pavement; Permeable interlocking concrete pavement; Pervious concrete; Porous asphalt; Nitrogen; Orthophosphate ID EASTERN NORTH-CAROLINA; WATER-QUALITY; ASPHALT PAVEMENT; POROUS ASPHALT; COLD CLIMATE; PERFORMANCE; SYSTEMS AB While permeable pavement is increasingly being used to control stormwater runoff, field-based, side-by-side investigations on the effects different pavement types have on nutrient concentrations present in stormwater runoff are limited. In 2009, the U.S. EPA constructed a 0.4-ha parking lot in Edison, New Jersey, that incorporated permeable interlocking concrete pavement (PICP), pervious concrete (PC), and porous asphalt (PA). Each permeable pavement type has four, 54.9-m(2), lined sections that direct all infiltrate into 5.7-m(3) tanks enabling complete volume collection and sampling. This paper highlights the results from a 12-month period when samples were collected from 13 rainfall/runoff events and analyzed for nitrogen species, orthophosphate, and organic carbon. Differences in infiltrate concentrations among the three permeable pavement types were assessed and compared with concentrations in rainwater samples and impervious asphalt runoff samples, which were collected as controls. Contrary to expectations based on the literature, the PA infiltrate had significantly larger total nitrogen (TN) concentrations than runoff and infiltrate from the other two permeable pavement types, indicating that nitrogen leached from materials in the PA strata. There was no significant difference in TN concentration between runoff and infiltrate from either PICP or PC, but TN in runoff was significantly larger than in the rainwater, suggesting meaningful inter-event dry deposition. Similar to other permeable pavement studies, nitrate was the dominant nitrogen species in the infiltrate. The PA infiltrate had significantly larger nitrite and ammonia concentrations than PICP and PC, and this was presumably linked to unexpectedly high pH in the PA infiltrate that greatly exceeded the optimal pH range for nitrifying bacteria. Contrary to the nitrogen results, the PA infiltrate had significantly smaller orthophosphate concentrations than in rainwater, runoff, and infiltrate from PICP and PC, and this was attributed to the high pH in PA infiltrate possibly causing rapid precipitation of orthophosphate with metal cations. Orthophosphate was exported from the PICP and PC, as evidenced by the significantly larger infiltrate concentrations compared with influent sources of rainwater and runoff. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Brown, Robert A.] US EPA, Oak Ridge Inst Sci & Educ, Edison, NJ 08837 USA. [Borst, Michael] US EPA, Edison, NJ 08837 USA. RP Brown, RA (reprint author), US EPA, Oak Ridge Inst Sci & Educ, 2890 Woodbridge Ave,MS-104, Edison, NJ 08837 USA. EM rob.brown.rab@gmail.com; borst.mike@epa.gov FU U.S. Department of Energy; U.S. Environmental Protection Agency FX The authors would like to thank Mr. Keith Kelty of the USEPA's Treatment Technology Evaluation Branch for overseeing the sample analyses and PARS Environmental under contract EP-C-10-054 for sample collection. The parking lot was constructed as a joint project with EPA's Office of Administration and Resources Management and Region 2. This project was supported in part by an appointment to the Research Participation Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and U.S. Environmental Protection Agency. NR 31 TC 1 Z9 1 U1 9 U2 53 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2015 VL 164 BP 74 EP 85 DI 10.1016/j.jenvman.2015.08.038 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA CU8WB UT WOS:000363823700010 PM 26348134 ER PT J AU Staggs, SE Keely, SP Ware, MW Schable, N See, MJ Gregorio, D Zou, X Su, CL Dubey, JP Villegas, EN AF Staggs, Sarah E. Keely, Scott P. Ware, Michael W. Schable, Nancy See, Mary Jean Gregorio, Dominic Zou, Xuan Su, Chunlei Dubey, J. P. Villegas, Eric N. TI The development and implementation of a method using blue mussels (Mytilus spp.) as biosentinels of Cryptosporidium spp. and Toxoplasma gondii contamination in marine aquatic environments SO PARASITOLOGY RESEARCH LA English DT Article DE Biosentinel; Cryptosporidium; Toxoplasma gondii; Water quality; Mytilus spp. ID ENHYDRA-LUTRIS-NEREIS; CRASSOSTREA-VIRGINICA; UNITED-STATES; SEA OTTERS; DREISSENA-POLYMORPHA; GENOME AMPLIFICATION; CHESAPEAKE BAY; WATER; OOCYSTS; PARVUM AB Surveillance monitoring for microbial water quality typically involves collecting single discrete grab samples for analyzing only one contaminant. While informative, current approaches suffer from poor recoveries and only provide a limited snapshot of the microbial contaminants only at the time of collection. To overcome these limitations, bivalves have been proposed as effective biosentinels of water quality particularly for their ability to efficiently concentrate and retain microbial contaminants for long periods of time. In this study, we examined the use of indigenous blue mussels (Mytilus spp.) as biosentinels to monitor for the presence of Toxoplasma gondii and Cryptosporidium water. An efficient method to extract oocyst DNA from various mussel tissues followed by PCR-based detection of these pathogens was developed, which resulted in the detection down to 10 oocysts. This method was then used to conduct a small survey in Point Lobos and Morro Bay, California to determine prevalence T. gondii and Cryptosporidium. Results revealed that mussels from Morro Bay were contaminated with T. gondii (33 %), while mussels from Point Lobos were contaminated with T. gondii (54 %) and Cryptosporidium (26.9 %) oocysts. Phylogenetic analysis using the SSU rRNA gene identified two novel Cryptosporidium parvum-like genotypes. Overall, this study demonstrated the application of using native California Mytilus spp. as biosentinels for pathogen contamination along the central California shorelines. More importantly, T. gondii and Cryptosporidium were found at higher prevalence rates in Morro Bay and in Point Lobos, an area not previously reported to be contaminated with these pathogens. C1 [Staggs, Sarah E.; Keely, Scott P.; Ware, Michael W.; Villegas, Eric N.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Schable, Nancy; See, Mary Jean] Dynamac Corp, Cincinnati, OH 45268 USA. [Gregorio, Dominic] State Water Resources Control Board, Sacramento, CA 95814 USA. [Zou, Xuan; Su, Chunlei] Univ Tennessee, Div Biol, Knoxville, TN 37996 USA. [Dubey, J. P.] USDA, Anim Res Serv, Beltsville, MD 20705 USA. [Villegas, Eric N.] US EPA, Microbiol & Chem Exposure Assessment Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Villegas, EN (reprint author), US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. EM villegas.eric@epa.gov RI Villegas, Eric/A-7373-2015 OI Villegas, Eric/0000-0002-8059-8588 FU United States Environmental Protection Agency through its Office of Research and Development FX We would like to thank Jim Lazorchak and Ken Fritz for technical guidance and Nichole Brinkman and Shannon Griffin for technical review. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the agency's administrative review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This work was conducted, in part, under a USEPA Region 3 Regional Methods Initiative Project. SES is an Oak Ridge Institute for Science and Education postdoctoral fellow. NR 44 TC 3 Z9 3 U1 1 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 EI 1432-1955 J9 PARASITOL RES JI Parasitol. Res. PD DEC PY 2015 VL 114 IS 12 BP 4655 EP 4667 DI 10.1007/s00436-015-4711-9 PG 13 WC Parasitology SC Parasitology GA CT6BM UT WOS:000362895700033 PM 26358104 ER PT J AU Winuthayanon, W Bernhardt, ML Padilla-Banks, E Myers, PH Edin, ML Lih, FB Hewitt, SC Korach, KS Williams, CJ AF Winuthayanon, Wipawee Bernhardt, Miranda L. Padilla-Banks, Elizabeth Myers, Page H. Edin, Matthew L. Lih, Fred B. Hewitt, Sylvia C. Korach, Kenneth S. Williams, Carmen J. TI Oviductal estrogen receptor alpha signalling prevents protease-mediated embryo death SO ELIFE LA English DT Article ID ZONA-PELLUCIDA; CORTICAL GRANULES; OOCYTE MATURATION; MOUSE EGGS; IN-VITRO; GENE; MICE; KALLIKREIN; EXPRESSION; RESPONSES AB Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation development. Here we show that conditional knockout (cKO) mice lacking estrogen receptor alpha (ER alpha) in oviduct and uterine epithelial cells have impaired fertilization due to a dramatic reduction in sperm migration. In addition, all successfully fertilized eggs die before the 2-cell stage due to persistence of secreted innate immune mediators including proteases. Elevated protease activity in cKO oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos transferred into cKO oviducts fail to develop normally unless rescued by concomitant transfer of protease inhibitors. Thus, suppression of oviductal protease activity mediated by estrogen-epithelial ER alpha signaling is required for fertilization and preimplantation embryo development. These findings have implications for human infertility and post-coital contraception. C1 [Winuthayanon, Wipawee; Bernhardt, Miranda L.; Padilla-Banks, Elizabeth; Hewitt, Sylvia C.; Korach, Kenneth S.; Williams, Carmen J.] Natl Inst Environm Hlth Sci, NIH, Reprod & Dev Biol Lab, Res Triangle Pk, NC 27709 USA. [Winuthayanon, Wipawee] Washington State Univ, Coll Vet Med, Sch Mol Biosci, Pullman, WA 99164 USA. [Myers, Page H.] Natl Inst Environm Hlth Sci, NIH, Comparat Med Branch, Res Triangle Pk, NC USA. [Edin, Matthew L.] Natl Inst Environm Hlth Sci, NIH, Immun Inflammat & Dis Lab, Res Triangle Pk, NC USA. [Lih, Fred B.] Natl Inst Environm Hlth Sci, NIH, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC USA. RP Winuthayanon, W (reprint author), Natl Inst Environm Hlth Sci, NIH, Reprod & Dev Biol Lab, Res Triangle Pk, NC 27709 USA. EM winuthayanonw@vetmed.wsu.edu; williamsc5@niehs.nih.gov FU National Institute of Environmental Health Sciences [1ZIAES70065, 1ZIAES025034, 1ZIAES050167, 1ZIAES102405] FX National Institute of 1ZIAES70065 Environmental Health Sciences Wipawee Winuthayanon Sylvia C Hewitt Kenneth S Korach; National Institute of 1ZIAES025034 Environmental Health Sciences Matthew L Edin; National Institute of 1ZIAES050167 Environmental Health Sciences Fred B Lih; National Institute of 1ZIAES102405 Environmental Health Sciences Miranda L Bernhardt Elizabeth Padilla-Banks Carmen J Williams; The funder had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 57 TC 0 Z9 0 U1 2 U2 4 PU ELIFE SCIENCES PUBLICATIONS LTD PI CAMBRIDGE PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND SN 2050-084X J9 ELIFE JI eLife PD NOV 26 PY 2015 VL 4 AR e10453 DI 10.7554/eLife.10453 PG 28 WC Biology SC Life Sciences & Biomedicine - Other Topics GA CX7IG UT WOS:000365874800001 ER PT J AU Lee, CR Zeldin, DC AF Lee, Craig R. Zeldin, Darryl C. TI Resolvin Infectious Inflammation by Targeting the Host Response SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID SEPSIS C1 [Lee, Craig R.] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA. [Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, NIH, Res Triangle Pk, NC USA. RP Lee, CR (reprint author), Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA. OI Lee, Craig/0000-0003-3595-5301 NR 5 TC 6 Z9 6 U1 4 U2 6 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 26 PY 2015 VL 373 IS 22 BP 2183 EP 2185 DI 10.1056/NEJMcibr1511280 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CW9YT UT WOS:000365354800020 PM 26605933 ER PT J AU Zhang, B Davis, WS AF Zhang, Bo Davis, Wayne S. TI Lessons from EPA on tracking pollutants SO NATURE LA English DT Letter C1 [Zhang, Bo] Minist Environm Protect, Informat Ctr, Beijing, Peoples R China. [Davis, Wayne S.] US EPA, Washington, DC 20460 USA. RP Zhang, B (reprint author), Minist Environm Protect, Informat Ctr, Beijing, Peoples R China. EM zhangbo@mep.gov.cn NR 0 TC 1 Z9 1 U1 3 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD NOV 26 PY 2015 VL 527 IS 7579 BP 446 EP 446 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW9XW UT WOS:000365352500027 PM 26607534 ER PT J AU Kuempel, ED Sweeney, LM Morris, JB Jarabek, AM AF Kuempel, Eileen D. Sweeney, Lisa M. Morris, John B. Jarabek, Annie M. TI Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE deposition; dosimetry models and methods; fibers; gases; inhaled particles; clearance and retention kinetics; interspecies extrapolation ID COMPUTATIONAL FLUID-DYNAMICS; HUMAN RESPIRATORY-TRACT; MULTIPLE-PATH MODEL; ALVEOLAR-INTERSTITIAL REGION; INSOLUBLE IRIDIUM PARTICLES; PHARMACOKINETIC PBPK MODEL; WALLED CARBON NANOTUBES; MONTE-CARLO-SIMULATION; LONG-TERM RETENTION; CERAMIC FIBERS RCF AB The purpose of this article is to provide an overview and practical guide to occupational health professionals concerning the derivation and use of dose estimates in risk assessment for development of occupational exposure limits (OELs) for inhaled substances. Dosimetry is the study and practice of measuring or estimating the internal dose of a substance in individuals or a population. Dosimetry thus provides an essential link to understanding the relationship between an external exposure and a biological response. Use of dosimetry principles and tools can improve the accuracy of risk assessment, and reduce the uncertainty, by providing reliable estimates of the internal dose at the target tissue. This is accomplished through specific measurement data or predictive models, when available, or the use of basic dosimetry principles for broad classes of materials. Accurate dose estimation is essential not only for dose-response assessment, but also for interspecies extrapolation and for risk characterization at given exposures. Inhalation dosimetry is the focus of this paper since it is a major route of exposure in the workplace. Practical examples of dose estimation and OEL derivation are provided for inhaled gases and particulates. C1 [Kuempel, Eileen D.] NIOSH, Educ & Informat Div, Cincinnati, OH 45226 USA. [Sweeney, Lisa M.] Henry M Jackson Fdn Adv Mil Med, Naval Med Res Unit Dayton, Wright Patterson AFB, OH USA. [Morris, John B.] Univ Connecticut, Sch Pharm, Storrs, CT USA. [Jarabek, Annie M.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. RP Kuempel, ED (reprint author), NIOSH, Educ & Informat Div, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM ekuempel@cdc.gov FU Naval Medical Research Unit Dayton Work Unit [60769] FX Dr. Sweeney's contributions to this work were funded by the Naval Medical Research Unit Dayton Work Unit Number 60769. NR 177 TC 3 Z9 3 U1 3 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD NOV 25 PY 2015 VL 12 SU 1 SI SI BP S18 EP S40 DI 10.1080/15459624.2015.1060328 PG 23 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CV6CQ UT WOS:000364358700002 PM 26551218 ER PT J AU Thomas, R AF Thomas, Russell TI TEMPORAL AND DOSE-RESPONSE PATHWAY ANALYSIS FOR PREDICTING CHRONIC CHEMICAL TOXICITY SO DRUG METABOLISM REVIEWS LA English DT Meeting Abstract CT 19th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) / 29th Meeting of the Japanese-Society-for-the-Study-of-Xenobiotics (JSSX) CY OCT 19-23, 2014 CL San Francisco, CA SP Int Soc Study Xenobiot, Japan Soc Study Xenobiot C1 [Thomas, Russell] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0360-2532 EI 1097-9883 J9 DRUG METAB REV JI Drug Metab. Rev. PD NOV 20 PY 2015 VL 47 SU 1 SI SI MA S21 BP 19 EP 19 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CX3PQ UT WOS:000365611800033 ER PT J AU Richardson, VM Richardson, SD Moyer, MP Simmons, JE DeAngelo, AB AF Richardson, Vicki M. Richardson, Susan D. Moyer, Mary P. Simmons, Jane Ellen DeAngelo, Anthony B. TI SIGNIFICANCE OF PH ON THE CYTOTOXIC POTENTIAL OF THE WATER DISINFECTION BY-PRODUCT IODOACETIC ACID SO DRUG METABOLISM REVIEWS LA English DT Meeting Abstract CT 19th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) / 29th Meeting of the Japanese-Society-for-the-Study-of-Xenobiotics (JSSX) CY OCT 19-23, 2014 CL San Francisco, CA SP Int Soc Study Xenobiot, Japan Soc Study Xenobiot C1 [Richardson, Vicki M.; Simmons, Jane Ellen; DeAngelo, Anthony B.] US EPA, ORD Nheerl Istd, Res Triangle Pk, NC 27711 USA. [Richardson, Susan D.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Moyer, Mary P.] INCELL Corp, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0360-2532 EI 1097-9883 J9 DRUG METAB REV JI Drug Metab. Rev. PD NOV 20 PY 2015 VL 47 SU 1 SI SI MA P11 BP 45 EP 46 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CX3PQ UT WOS:000365611800089 ER PT J AU Mazur, CS Marchitti, SA Zastre, J AF Mazur, Christopher S. Marchitti, Satori A. Zastre, Jason TI P-GLYCOPROTEIN INHIBITION BY THE POTENTIAL ENDOCRINE DISRUPTING FUNGICIDE PROPICONAZOLE AND METABOLITES: IMPLICATIONS FOR CONAZOLE PESTICIDE-DRUG INTERACTIONS SO DRUG METABOLISM REVIEWS LA English DT Meeting Abstract CT 19th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) / 29th Meeting of the Japanese-Society-for-the-Study-of-Xenobiotics (JSSX) CY OCT 19-23, 2014 CL San Francisco, CA SP Int Soc Study Xenobiot, Japan Soc Study Xenobiot C1 [Mazur, Christopher S.; Marchitti, Satori A.] US EPA, Athens, GA USA. [Zastre, Jason] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0360-2532 EI 1097-9883 J9 DRUG METAB REV JI Drug Metab. Rev. PD NOV 20 PY 2015 VL 47 SU 1 SI SI MA P446 BP 249 EP 250 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CX3PQ UT WOS:000365611800494 ER PT J AU Cervantes-Yoshida, K Leidy, RA Carlson, SM AF Cervantes-Yoshida, Kristina Leidy, Robert A. Carlson, Stephanie M. TI Contemporary Land Change Alters Fish Communities in a San Francisco Bay Watershed, California, USA SO PLOS ONE LA English DT Article ID MACROINVERTEBRATE ASSEMBLAGES; STREAM BIODIVERSITY; URBANIZATION; LANDSCAPE; HABITAT; CATCHMENT; COVER; SCALE; CLASSIFICATION; PERSISTENCE AB Urbanization is one of the leading threats to freshwater biodiversity, and urban regions continue to expand globally. Here we examined the relationship between recent urbanization and shifts in stream fish communities. We sampled fishes at 32 sites in the Alameda Creek Watershed, near San Francisco, California, in 1993-1994 and again in 2009, and we quantified univariate and multivariate changes in fish communities between the sampling periods. Sampling sites were classified into those downstream of a rapidly urbanizing area ("urbanized sites"), and those found in less impacted areas ("low-impacted sites"). We calculated the change from non-urban to urban land cover between 1993 and 2009 at two scales for each site (the total watershed and a 3km buffer zone immediately upstream of each site). Neither the mean relative abundance of native fish nor nonnative species richness changed significantly between the survey periods. However, we observed significant changes in fish community composition (as measured by Bray-Curtis dissimilarity) and a decrease in native species richness between the sampling periods at urbanized sites, but not at low-impacted sites. Moreover, the relative abundance of one native cyprinid (Lavinia symmetricus) decreased at the urbanized sites but not at low-impacted sites. Increased urbanization was associated with changes in the fish community, and this relationship was strongest at the smaller (3km buffer) scale. Our results suggest that ongoing land change alters fish communities and that contemporary resurveys are an important tool for examining how freshwater taxa are responding to recent environmental change. C1 [Cervantes-Yoshida, Kristina; Carlson, Stephanie M.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Leidy, Robert A.] US EPA, San Francisco, CA USA. RP Cervantes-Yoshida, K (reprint author), San Francisco Bay Reg Water Qual Control Board, Oakland, CA 94612 USA. EM kcervantesyoshida@gmail.com FU National Science Foundation Graduate Research Fellowship Program [DGE1106400]; Berkeley Research Impact Initiative (BRII) - UC Berkeley Library FX Support was provided by the National Science Foundation Graduate Research Fellowship Program, grant number: DGE1106400 to KCY [https://www.nsfgrfp.org]. Publication made possible in part by support from the Berkeley Research Impact Initiative (BRII) sponsored by the UC Berkeley Library. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 1 Z9 1 U1 3 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 18 PY 2015 VL 10 IS 11 AR e0141707 DI 10.1371/journal.pone.0141707 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW7CD UT WOS:000365154600020 PM 26580560 ER PT J AU Hofmann, JN Beane Freeman, LE Lynch, CF Andreotti, G Thomas, KW Sandler, DP Savage, SA Alavanja, MC AF Hofmann, Jonathan N. Beane Freeman, Laura E. Lynch, Charles F. Andreotti, Gabriella Thomas, Kent W. Sandler, Dale P. Savage, Sharon A. Alavanja, Michael C. TI THE BIOMARKERS OF EXPOSURE AND EFFECT IN AGRICULTURE (BEEA) STUDY: RATIONALE, DESIGN, METHODS, AND PARTICIPANT CHARACTERISTICS SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID PESTICIDE EXPOSURE; URINARY CONCENTRATIONS; OCCUPATIONAL-EXPOSURE; TELOMERE LENGTH; NATIONAL-HEALTH; CANCER-RISK; METAANALYSIS; APPLICATORS; METABOLITES AB Agricultural exposures including pesticides, endotoxin, and allergens have been associated with risk of various cancers and other chronic diseases, although the biological mechanisms underlying these associations are generally unclear. To facilitate future molecular epidemiologic investigations, in 2010 the study of Biomarkers of Exposure and Effect in Agriculture (BEEA) was initiated within the Agricultural Health Study, a large prospective cohort in Iowa and North Carolina. Here the design and methodology of BEEA are described and preliminary frequencies for participant characteristics and current agricultural exposures are reported. At least 1,600 male farmers over 50 years of age will be enrolled in the BEEA study. During a home visit, participants are asked to complete a detailed interview about recent agricultural exposures and provide samples of blood, urine, and (since 2013) house dust. As of mid-September 2014, in total, 1,233 participants have enrolled. Most of these participants (83%) were still farming at the time of interview. Among those still farming, the most commonly reported crops were corn (81%) and soybeans (74%), and the most frequently noted animals were beef cattle (35%) and hogs (13%). There were 861 (70%) participants who reported occupational pesticide use in the 12 months prior to interview; among these participants, the most frequently noted herbicides were glyphosate (83%) and 2,4-D (72%), and most commonly reported insecticides were malathion (21%), cyfluthrin (13%), and permethrin (12%). Molecular epidemiologic investigations within BEEA have the potential to yield important new insights into the biological mechanisms through which these or other agricultural exposures influence disease risk. C1 [Hofmann, Jonathan N.; Beane Freeman, Laura E.; Andreotti, Gabriella; Alavanja, Michael C.] NCI, Div Canc Epidemiol & Genet, Occupat & Environm Epidemiol Branch, Bethesda, MD 20892 USA. [Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA. [Thomas, Kent W.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Sandler, Dale P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. [Savage, Sharon A.] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Bethesda, MD 20892 USA. RP Hofmann, JN (reprint author), NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Bethesda, MD 20892 USA. EM hofmannjn@mail.nih.gov RI Savage, Sharon/B-9747-2015; Beane Freeman, Laura/C-4468-2015; OI Savage, Sharon/0000-0001-6006-0740; Beane Freeman, Laura/0000-0003-1294-4124; Sandler, Dale/0000-0002-6776-0018 FU NIH, National Cancer Institute [Z01CP010119]; National Institute of Environmental Health Sciences [Z01 ES 049030]; United States Environmental Protection Agency through an inter-Agency agreement FX This work was supported by the Intramural Research Program of the NIH, National Cancer Institute (Z01CP010119) and National Institute of Environmental Health Sciences (Z01 ES 049030), and by the United States Environmental Protection Agency through an inter-Agency agreement. The United States Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. It has been subjected to Agency review and approved for publication. We gratefully acknowledge Amy Miller, Kate Torres, Sandor Balogh, Linda Gowen, Himanshi Singh, and Marsha Dunn (Westat, Inc., Rockville, Maryland) for study coordination, data management, and field research efforts. We also thank Debra Lande, Debra Podaril, and Jennifer Hamilton from the field research team at the University of Iowa for their efforts on this study. The ongoing participation of the Agricultural Health Study participants is indispensable and sincerely appreciated. NR 34 TC 1 Z9 1 U1 3 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PD NOV 17 PY 2015 VL 78 IS 21-22 BP 1338 EP 1347 DI 10.1080/15287394.2015.1091414 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CY2BD UT WOS:000366212900004 PM 26555155 ER PT J AU Regli, S Chen, J Messner, M Elovitz, MS Letkiewicz, FJ Pegram, RA Pepping, TJ Richardson, SD Wright, JM AF Regli, Stig Chen, Jimmy Messner, Michael Elovitz, Michael S. Letkiewicz, Frank J. Pegram, Rex A. Pepping, T. J. Richardson, Susan D. Wright, J. Michael TI Estimating Potential Increased Bladder Cancer Risk Due to Increased Bromide Concentrations in Sources of Disinfected Drinking Waters SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BY-PRODUCT BROMODICHLOROMETHANE; MAMMALIAN-CELL TOXICITY; HALOACETIC ACIDS; CHLORINATION; TRIHALOMETHANES; SPECIATION; CHLORAMINATION; GENOTOXICITY; DBPS; RICH AB Public water systems are increasingly facing higher bromide levels in their source waters from anthropogenic contamination through coal-fired power plants, conventional oil and gas extraction, textile mills, and hydraulic fracturing. Climate change is likely to exacerbate this in coming years. We estimate bladder cancer risk from potential increased bromide levels in source waters of disinfecting public drinking water systems in the United States. Bladder cancer is the health end point used by the United States Environmental Protection Agency (EPA) in its benefits analysis for regulating disinfection byproducts in drinking water. We use estimated increases in the mass of the four regulated trihalomethanes (THM4) concentrations (due to increased bromide incorporation) as the surrogate disinfection byproduct (DBP) occurrence metric for informing potential bladder cancer risk. We estimate potential increased excess lifetime bladder cancer risk as a function of increased source water bromide levels. Results based on data from 201 drinking water treatment plants indicate that a bromide increase of 50 mu g/L could result in a potential increase of between 10(-3) and 10(-4) excess lifetime bladder cancer risk in populations served by roughly 90% of these plants. C1 [Regli, Stig; Chen, Jimmy; Messner, Michael; Pepping, T. J.] US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA. [Elovitz, Michael S.] US EPA, Off Res & Dev, Natl Risk Management Lab, Cincinnati, OH 45268 USA. [Letkiewicz, Frank J.] Cadmus Grp, Bethesda, MD 20814 USA. [Pegram, Rex A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Pepping, T. J.] US DOE, Oak Ridge Inst Sci & Educ Internship, Res Participat Program, Oak Ridge, TN 37830 USA. [Richardson, Susan D.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Wright, J. Michael] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. RP Regli, S (reprint author), US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA. EM regli.stig@epa.gov NR 66 TC 9 Z9 9 U1 8 U2 54 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 17 PY 2015 VL 49 IS 22 BP 13094 EP 13102 DI 10.1021/acs.est.5b03547 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CW7AV UT WOS:000365151200002 PM 26489011 ER PT J AU Kapoor, V Li, X Elk, M Chandran, K Impellitteri, CA Domingo, JWS AF Kapoor, Vikram Li, Xuan Elk, Michael Chandran, Kartik Impellitteri, Christopher A. Domingo, Jorge W. Santo TI Impact of Heavy Metals on Transcriptional and Physiological Activity of Nitrifying Bacteria SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NITROSOMONAS-EUROPAEA 19718; ACTIVATED-SLUDGE; WASTE-WATER; NITRIFICATION INHIBITION; NITROSOCOCCUS-MOBILIS; NITRITE OXIDATION; AMMONIA; ZINC; EXPRESSION; DIVERSITY AB Heavy metals can inhibit nitrification, a key process for nitrogen removal in wastewater treatment. The transcriptional responses of amoA, hao, nirK, and norB were measured in conjunction with specific oxygen uptake rate (sOUR) for nitrifying enrichment cultures exposed to different metals (Ni(II), Zn(II), Cd(II), and Pb(II)). There was significant decrease in sOUR with increasing concentrations for Ni(II) (0.03-3 mg/L), Zn(II)(0.1-10 mg/L), and Cd(II) (0.03-1 mg/L) (p < 0.05). However, no considerable changes in sOUR were observed with Pb(II) (1-100 mg/L), except at a dosage of 1000 mg/L causing 84% inhibition. Based on RT-qPCR data, the transcript levels of amoA and hao decreased when exposed to Ni(II) dosages. Slight up-regulation of amoA, hao, and nirK (0.5-1.5-fold) occurred after exposure to 0.3-3 mg/L Zn(II), although their expression decreased for 10 mg/L Zn(II). With the exception of 1000 mg/L Pb(II), stimulation of all genes occurred on Cd(II) and Pb(II) exposure. While overall the results show that RNA-based function-specific assays can be used as potential surrogates for measuring nitrification activity, the degree of inhibition inferred from sOUR and gene transcription is different. We suggest that variations in transcription of functional genes may supplement sOUR based assays as early warning indicators of upsets in nitrification. C1 [Kapoor, Vikram; Li, Xuan; Impellitteri, Christopher A.; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Elk, Michael] Pegasus Tech Serv Inc, Cincinnati, OH 45268 USA. [Chandran, Kartik] Columbia Univ, Dept Earth & Environm Engn, New York, NY 10027 USA. RP Domingo, JWS (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM santodomingo.jorge@epa.gov NR 49 TC 4 Z9 4 U1 14 U2 91 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 17 PY 2015 VL 49 IS 22 BP 13454 EP 13462 DI 10.1021/acs.est.5b02748 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CW7AV UT WOS:000365151200042 PM 26501957 ER PT J AU Mele, E Donner, E Juhasz, AL Brunetti, G Smith, E Betts, AR Castaldi, P Deiana, S Scheckel, KG Lombi, E AF Mele, Elena Donner, Erica Juhasz, Albert L. Brunetti, Gianluca Smith, Euan Betts, Aaron R. Castaldi, Paola Deiana, Salvatore Scheckel, Kirk G. Lombi, Enzo TI In Situ Fixation of Metal(loid)s in Contaminated Soils: A Comparison of Conventional, Opportunistic, and Engineered Soil Amendments SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID VALENT IRON NANOPARTICLES; WATER TREATMENT RESIDUALS; ARSENIC BIOACCESSIBILITY; LEAD BIOAVAILABILITY; MINE TAILINGS; RED MUD; PHOSPHATE; VITRO; ABSORPTION; IMMOBILIZATION AB This study aimed to assess and compare the in vitro and in vivo bioaccessibility/bioavailability of As and Pb in a mining contaminated soil (As, 2267 mg kg(-1); Pb, 1126 mg kg(-1)), after the addition of conventional (phosphoric acid), opportunistic [water treatment residues (WTRs)], and engineered [nano- and microscale zero valent iron (ZVI)] amendments. Phosphoric acid was the only amendment that could significantly decrease Pb bioaccessibility with respect to untreated soil (41 and 47% in the gastric phase and 2.1 and 8.1% in the intestinal phases, respectively), giving treatment effect ratios (TERs, the bioaccessibility in the amended soil divided by the bioaccessibility in the untreated soil) of 0.25 and 0.87 in the gastric and intestinal phase, respectively. The in vivo bioavailability of Pb decreased in the phosphate treatment relative to the untreated soil (6 and 24%, respectively), and also in the Fe WTR 2% (12%) and nZVI-2 (13%) treatments. The ZVI amendments caused a decrease in As bioaccessibility, with the greatest decrease in the nZVI2-treated soil (TERs of 0.59 and 0.64 in the gastric and intestinal phases, respectively). Arsenic X-ray absorption near-edge spectroscopy analysis indicated that most of the As in the untreated soil was present as As(V) associated with Fe mineral phases, whereas in the treated soil, the proportion of arsenosiderite increased. Arsenite was present only as a minor species (3-5%) in the treated soils, with the exception of an nZVI treatment [similar to 14% of As(III)], suggesting a partial reduction of As(V) to As(III) caused by nZVI oxidation. C1 [Mele, Elena; Castaldi, Paola; Deiana, Salvatore] Univ Sassari, Dipartimento Agr, Sez Sci & Tecnol Ambientali & Alimentari, I-07100 Sassari, Italy. [Donner, Erica; Juhasz, Albert L.; Brunetti, Gianluca; Smith, Euan; Lombi, Enzo] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Adelaide, SA 5095, Australia. [Donner, Erica; Juhasz, Albert L.; Brunetti, Gianluca; Smith, Euan] CRC CARE, Salisbury, SA 5106, Australia. [Betts, Aaron R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Betts, Aaron R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. RP Lombi, E (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg 10,Mawson Lakes Campus, Adelaide, SA 5095, Australia. EM enzo.lombi@unisa.edu.au RI Juhasz, Albert/F-6600-2011; Donner, Erica/A-4809-2012; Lombi, Enzo/F-3860-2013; BM, MRCAT/G-7576-2011; OI Juhasz, Albert/0000-0002-1164-4085; Donner, Erica/0000-0001-6465-2233; Lombi, Enzo/0000-0003-3384-0375; Scheckel, Kirk/0000-0001-9326-9241; Castaldi, Paola/0000-0002-4691-820X FU Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE) - Australian Government's Cooperative Research Centres Programme; Australian Research Council (ARC) through a Future Fellowship [FT100100337]; Italian Ministry of Research and University (MIUR), PRIN; DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]; EPA; Department of Energy; MRCAT member institutions FX The work has been supported by the Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), whose activities are funded by the Australian Government's Cooperative Research Centres Programme. Support was provided to E.L. by the Australian Research Council (ARC) through a Future Fellowship (FT100100337). This study was also financially supported by the Italian Ministry of Research and University (MIUR), PRIN 2010-11. MRCAT operations are supported by the Department of Energy and the MRCAT member institutions. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. Although the EPA contributed to this article, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent the EPA's views or policies. NR 63 TC 4 Z9 4 U1 13 U2 59 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 17 PY 2015 VL 49 IS 22 BP 13501 EP 13509 DI 10.1021/acs.est.5b01356 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CW7AV UT WOS:000365151200047 PM 26457447 ER PT J AU Fox, MA Sheehan, MC Burke, TA AF Fox, Mary A. Sheehan, Mary C. Burke, Thomas A. TI A Risk Assessment Approach for Policy Evaluation: New Jersey Case Studies SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE environmental policy; risk assessment; mercury; trichloroethylene; PCBs AB Monitoring environmental policy progress often focuses on contaminant concentrations while policy goals address health. To bridge this gap, we developed policy evaluation case studies applying risk assessment methods to explore population health risks of chemical exposures before and after policy implementation. Beginning in the 1970s the New Jersey Department of Environmental Protection provided some of the United States' first data on contaminants including trichloroethylene in drinking water and polychlorinated biphenyls (PCBs) in fish. These data provide a unique opportunity to evaluate environmental policies. The 1979 PCB manufacturing ban succeeded in reducing exposure and risk, but the persistence of these compounds in local fish requires continued state and local consumption advisories. The positive impact of drinking water standards for trichloroethylene was reflected in declining detection in public water supplies from the late 1970s to 2005, although maximum concentrations in a small percentage of supplies remain above standards. Our case studies show success and progress, and the need for multiple policies in combination when conditions warrant. Tracking specific policies and contaminants using risk assessment methods can be a valuable tool for policy evaluation and can foster population-based environmental health research. Pollution prevention policies are warranted for chemicals that persist in the environment. C1 [Fox, Mary A.] Johns Hopkins Univ, Dept Hlth Policy & Management, Baltimore, MD 21205 USA. [Sheehan, Mary C.] Johns Hopkins Univ, Risk Sci & Publ Policy Inst, Baltimore, MD 21205 USA. [Burke, Thomas A.] US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Fox, MA (reprint author), Johns Hopkins Univ, Dept Hlth Policy & Management, 624 N Broadway,Room 407, Baltimore, MD 21205 USA. EM mfox9@jhu.edu FU USEPA [R83399101-0] FX This article was developed under a STAR Research Assistance Agreement No. R83399101-0 awarded by the USEPA. It has not been formally reviewed by the USEPA. The views expressed in this document are solely those of the authors and the USEPA does not endorse any products or commercial services mentioned in this publication. NR 33 TC 0 Z9 0 U1 3 U2 16 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD NOV 17 PY 2015 VL 21 IS 8 BP 2258 EP 2272 DI 10.1080/10807039.2015.1046982 PG 15 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CR5KB UT WOS:000361379300017 ER PT J AU Hoffman, JC Sierszen, ME Cotter, AM AF Hoffman, Joel C. Sierszen, Michael E. Cotter, Anne M. TI Fish tissue lipid-C:N relationships for correcting C-13 values and estimating lipid content in aquatic food-web studies SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY LA English DT Article ID STABLE-ISOTOPE ANALYSES; MUSCLE-TISSUE; CORRECTION MODELS; CARBON ISOTOPES; LAKE-SUPERIOR; DELTA-C-13; NITROGEN; EXTRACTION; FRACTIONATION; RATIOS AB RationaleNormalizing C-13 values of animal tissue for lipid content is necessary to accurately interpret food-web relationships from stable isotope analysis. To reduce the effort and expense associated with chemical extraction of lipids, various studies have tested arithmetic mass balance to mathematically normalize C-13 values for lipid content; however, the approach assumes that lipid content is related to the tissue C:N ratio. MethodsWe evaluated two commonly used models for estimating tissue lipid content based on C:N ratio (a mass balance model and a stoichiometric model) by comparing model predictions to measure the lipid content of white muscle tissue. We then determined the effect of lipid model choice on C-13 values normalized using arithmetic mass balance. To do so, we used a collection of fish from Lake Superior spanning a wide range in lipid content (5% to 73% lipid). ResultsWe found that the lipid content was positively related to the bulk muscle tissue C:N ratio. The two different lipid models produced similar estimates of lipid content based on tissue C:N, within 6% for tissue C:N values <7. Normalizing C-13 values using an arithmetic mass-balance equation based on either model yielded similar results, with a small bias (<1) compared with results based on chemical extraction. ConclusionsAmong-species consistency in the relationship between fish muscle tissue C:N ratio and lipid content supports the application of arithmetic mass balance to normalize C-13 values for lipid content. The uncertainty associated with both lipid extraction quality and choice of model parameters constrains the achievable precision of normalized C-13 values to about +/- 1.0 parts per thousand. Published in 2015. This article is a U.S. Government work and is in the public domain in the U.S.A. C1 [Hoffman, Joel C.; Sierszen, Michael E.; Cotter, Anne M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. RP Hoffman, JC (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM hoffman.joel@epa.gov OI Hoffman, Joel/0000-0002-5413-8799 NR 30 TC 0 Z9 0 U1 3 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0951-4198 EI 1097-0231 J9 RAPID COMMUN MASS SP JI Rapid Commun. Mass Spectrom. PD NOV 15 PY 2015 VL 29 IS 21 BP 2069 EP 2077 DI 10.1002/rcm.7367 PG 9 WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA CT2QJ UT WOS:000362647900019 PM 26443408 ER PT J AU Tolaymat, T El Badawy, A Sequeira, R Genaidy, A AF Tolaymat, Thabet El Badawy, Amro Sequeira, Reynold Genaidy, Ash TI An integrated science-based methodology to assess potential risks and implications of engineered nanomaterials SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Engineered nanomaterials; Risks to society, environment, and economy; Knowledge synthesis; Algorithmic computational methodology; Effects on environmental and societal health ID SILVER NANOPARTICLES; ENVIRONMENTAL TRANSFORMATIONS; TOXICITY; DELIVERY; RELEASE; PLANTS AB There is an urgent need for broad and integrated studies that address the risks of engineered nanomaterials (ENMs) along the different endpoints of the society, environment, and economy (SEE) complex adaptive system. This article presents an integrated science-based methodology to assess the potential risks of engineered nanomaterials. To achieve the study objective, two major tasks are accomplished, knowledge synthesis and algorithmic computational methodology. The knowledge synthesis task is designed to capture "what is known" and to outline the gaps in knowledge from ENMs risk perspective. The algorithmic computational methodology is geared toward the provision of decisions and an understanding of the risks of ENMs along different endpoints for the constituents of the SEE complex adaptive system. The approach presented herein allows for addressing the formidable task of assessing the implications and risks of exposure to ENMs, with the long term goal to build a decision-support system to guide key stakeholders in the SEE system towards building sustainable ENMs and nano-enabled products. Published by Elsevier B.V. C1 [Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [El Badawy, Amro] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA. [Sequeira, Reynold] Univ Cincinnati, Cincinnati, OH 45221 USA. [Genaidy, Ash] WorldTek Inc, Cincinnati, OH 45249 USA. RP Tolaymat, T (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM tolaymat.thabet@epa.gov FU NRMRL of the USEPA, Office of Research and Development FX This research was funded by the NRMRL of the USEPA, Office of Research and Development. The paper has not been subjected to the Agency's internal review; therefore, the opinions expressed in this paper are those of the author(s) and do not, necessarily, reflect the official positions and policies of the USEPA. NR 29 TC 4 Z9 5 U1 3 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV 15 PY 2015 VL 298 BP 270 EP 281 DI 10.1016/j.jhazmat.2015.04.019 PG 12 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CQ4SV UT WOS:000360595800030 PM 26079368 ER PT J AU Xue, JP Zartarian, V Mintz, B Weber, M Bailey, K Geller, A AF Xue, Jianping Zartarian, Valerie Mintz, Bruce Weber, Marc Bailey, Ken Geller, Andrew TI Modeling tribal exposures to methyl mercury from fish consumption SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Tribal; Fish consumption; Exposures; SHEDS-Dietary; Mercury ID METHYLMERCURY; NHANES; POPULATION; BENEFITS; RISKS AB Exposure assessment and risk management considerations for tribal fish consumption are different than for the general U.S. population because of higher fish intake from subsistence fishing and/or from unique cultural practices. This research summarizes analyses of available data and methodologies for estimating tribal fish consumption exposures to methyl mercury (MeHg). Large MeHg fish tissue data sets from the Environmental Protections Agency's (EPA's) Office of Water, USGS's EMMMA program, and other data sources, were integrated, analyzed, and combined with fish intake (consumption) data for exposure analyses using EPA's SHEDS-Dietary model. Results were mapped with GIS tools to depict spatial distributions of the MeHg in fish tissues and fish consumption exposure patterns. Contribution analyses indicates the major sources for those exposures, such as type and length of fish, geographical distribution (water bodies), and dietary exposure patterns. Sensitivity analyses identify the key variables and exposure pathways. Our results show that MeHg exposure of tribal populations from fish are about 3 to 10 times higher than the US general population and that exposure poses potential health risks. The estimated risks would be reduced as much as 50%, especially for high percentiles, just by avoiding consumption of fish species with higher MeHg concentrations such as walleye and bowfin, even without changing total fish intake. These exposure assessment methods and tools can help inform decisions regarding meal sizes and frequency, types of fish and water bodies to avoid, and other factors to minimize exposures and potential health risks from contaminated fish on tribal lands. Published by Elsevier B.V. C1 [Xue, Jianping; Zartarian, Valerie; Mintz, Bruce] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Weber, Marc] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. [Bailey, Ken] US EPA, Off Sci Policy, Res Triangle Pk, NC 27709 USA. [Geller, Andrew] US EPA, Off Res & Dev, Sustainable & Hlth Commun Res Program, Res Triangle Pk, NC 27709 USA. RP Xue, JP (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA. EM xue.jianping@epa.gov OI Weber, Marc/0000-0002-9742-4744 NR 30 TC 4 Z9 5 U1 2 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 15 PY 2015 VL 533 BP 102 EP 109 DI 10.1016/j.scitotenv.2015.06.070 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CQ0LV UT WOS:000360288300014 PM 26151654 ER PT J AU Liang, SD Jia, HF Yang, C Melching, C Yuan, YP AF Liang, Shidong Jia, Haifeng Yang, Cong Melching, Charles Yuan, Yongping TI A pollutant load hierarchical allocation method integrated in an environmental capacity management system for Zhushan Bay, Taihu Lake SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE TMDL; Environmental capacity management; Pollutant load hierarchical allocation; EFDC; WASP; Taihu Lake ID MAXIMUM DAILY LOAD; SIMULATION-OPTIMIZATION APPROACH; WATER-QUALITY MODEL; WASTE-LOAD; CHINA; RIVER; EUTROPHICATION; NUTRIENT; UNCERTAINTY; RESPONSES AB An environmental capacity management (ECM) system was developed to help practically implement a Total Maximum Daily Load (TMDL) for a key bay in a highly eutrophic lake in China. The ECM system consists of a simulation platform for pollutant load calculation and a pollutant load hierarchical allocation (PLHA) system. The simulation platform was developed by linking the Environmental Fluid Dynamics Code (EFDC) and Water Quality Analysis Simulation Program (WASP). In the PLHA, pollutant loads were allocated top-down in several levels based on characteristics of the pollutant sources. Different allocation methods could be used for the different levels with the advantages of each method combined over the entire allocation. Zhushan Bay of Taihu Lake, one of the most eutrophic lakes in China, was selected as a case study. The allowable loads of total nitrogen, total phosphorus, ammonia, and chemical oxygen demand were found to be 2122.2, 94.9, 1230.4, and 5260.0 t . yr(-1), respectively. The PLHA for the case study consists of 5 levels. At level 0, loads are allocated to those from the lakeshore direct drainage, atmospheric deposition, internal release, and tributary inflows. At level 1 the loads allocated to tributary inflows are allocated to the 3 tributaries. At level 2, the loads allocated to one inflow tributary are allocated to upstream areas and local sources along the tributary. At level 3, the loads allocated to local sources are allocated to the point and non-point sources from different towns. At level 4, the loads allocated to non-point sources in each town are allocated to different villages. Compared with traditional forms of pollutant load allocation methods, PLHA can combine the advantages of different methods which put different priority weights on equity and efficiency, and the PLHA is easy to understand for stakeholders and more flexible to adjust when applied in practical cases. (C) 2015 Elsevier B.V. All rights reserved. C1 [Liang, Shidong; Jia, Haifeng; Yang, Cong] Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China. [Melching, Charles] Melching Water Solut, Greenfield, WI 53221 USA. [Yuan, Yongping] US EPA, Landscape Ecol Branch, Div Environm Sci, Natl Exposure Res Lab,Off Res & Dev, Las Vegas, NV 89119 USA. RP Jia, HF (reprint author), Tsinghua Univ, Sch Environm, 1 Qinghuayuan, Beijing 100084, Peoples R China. EM emblembl@sina.com; jhf@tsinghua.edu.cn; Yangcong09@tsinghua.edu.cn; steve.melching17@gmail.com; Yuan.yongping@epa.gov FU National Water Pollution Control Special Project [2009ZX07526-005-04]; National Natural Science Foundation [51278267]; Programme of Introducing Talents of Discipline to Universities (the 111 Project) [B07002] FX The authors thank the Changzhou Meteorological Station, Hydrological Station, and Environmental Monitoring Centre for providing data for this study. This research was supported by the National Water Pollution Control Special Project no. 2009ZX07526-005-04, National Natural Science Foundation Project no. 51278267, and the Programme of Introducing Talents of Discipline to Universities (the 111 Project) (B07002). NR 52 TC 2 Z9 2 U1 17 U2 107 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 15 PY 2015 VL 533 BP 223 EP 237 DI 10.1016/j.scitotenv.2015.06.116 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA CQ0LV UT WOS:000360288300026 PM 26172589 ER PT J AU Whitmee, S Haines, A Beyrer, C Boltz, F Capon, AG Dias, BFDS Ezeh, A Frumkin, H Gong, P Head, P Horton, R Mace, GM Marten, R Myers, SS Nishtar, S Osofsky, SA Pattanayak, SK Pongsiri, MJ Romanelli, C Soucat, A Vega, J Yach, D AF Whitmee, Sarah Haines, Andy Beyrer, Chris Boltz, Frederick Capon, Anthony G. Dias, Braulio Ferreira de Souza Ezeh, Alex Frumkin, Howard Gong, Peng Head, Peter Horton, Richard Mace, Georgina M. Marten, Robert Myers, Samuel S. Nishtar, Sania Osofsky, Steven A. Pattanayak, Subhrendu K. Pongsiri, Montira J. Romanelli, Cristina Soucat, Agnes Vega, Jeanette Yach, Derek TI Safeguarding human health in the Anthropocene epoch: report of The Rockefeller Foundation-Lancet Commission on planetary health SO LANCET LA English DT Review ID GREENHOUSE-GAS EMISSIONS; CARBON-DIOXIDE EMISSIONS; GLOBAL FOOD SECURITY; RURAL SOUTH-AFRICA; CLIMATE-CHANGE; ENVIRONMENTAL-CHANGE; INFECTIOUS-DISEASES; ECOSYSTEM SERVICES; HURRICANE-KATRINA; PUBLIC-HEALTH C1 [Whitmee, Sarah; Mace, Georgina M.] UCL, Ctr Biodivers & Environm Res, London WC1E 6BT, England. [Haines, Andy; Marten, Robert] London Sch Hyg & Trop Med, London WC1, England. [Beyrer, Chris] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Boltz, Frederick; Marten, Robert] Rockefeller Fdn, New York, NY USA. [Capon, Anthony G.] United Nations Univ, Int Inst Global Hlth, Kuala Lumpur, Malaysia. [Dias, Braulio Ferreira de Souza; Romanelli, Cristina] Convent Biol Divers, Montreal, PQ, Canada. [Ezeh, Alex] African Populat & Hlth Res Ctr, Nairobi, Kenya. [Frumkin, Howard] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Gong, Peng] Tsinghua Univ, Ctr Earth Syst Sci, Beijing 100084, Peoples R China. [Head, Peter] Ecol Sequestrat Trust, London, England. [Horton, Richard] Lancet, London, England. [Myers, Samuel S.] Harvard Univ, Ctr Environm, Cambridge, MA 02138 USA. [Myers, Samuel S.] Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA. [Nishtar, Sania] Heartfile, Islamabad, Pakistan. [Osofsky, Steven A.] Wildlife Conservat Soc, Oakton, VA USA. [Pattanayak, Subhrendu K.] Duke Univ, Sanford Sch Publ Policy, Durham, NC USA. [Pattanayak, Subhrendu K.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Pongsiri, Montira J.] US EPA, Washington, DC 20460 USA. [Soucat, Agnes] World Bank, Washington, DC 20433 USA. [Vega, Jeanette] Natl Chilean Publ Hlth Insurance Agcy, Santiago, Chile. [Yach, Derek] Vital Grp, New York, NY USA. RP Whitmee, S (reprint author), UCL, Dept Genet Evolut & Environm, Ctr Biodivers & Environm Res, London WC1E 6BT, England. EM s.whitmee@ucl.ac.uk RI Mace, Georgina/I-3072-2016; Romanelli, Cristina/D-6243-2016; OI Mace, Georgina/0000-0001-8965-5211; Romanelli, Cristina/0000-0002-0642-4563; Whitmee, Sarah/0000-0001-9161-868X; Ezeh, Alex/0000-0002-1309-4697 FU Rockefeller Foundation; Medical Research Council; Wellcome Trust; NERC; Department for Environment, Food Rural Affairs; Leverhulme Trust; Bill & Melinda Gates Foundation; Winslow Foundation FX All authors declare that the work of the Commission on Planetary Health was supported by The Rockefeller Foundation. SW, AH, and GMM were compensated for their time working on the Commission. AH, GMM, and PG are also members of the Lancet Commission on Health and Climate Change. AH has received funds from the Medical Research Council and from the Wellcome Trust for research on global environmental change and health. RH is the editor of The Lancet. GMM chaired the Royal Society science-policy report on Resilience to Extreme Weather, is a trustee of the World Wide Fund for Nature UK, a member of the UK Government Natural Capital Committee (England), and a member of Council of the Natural Environment Research Council (NERC) and the Royal Society; she has received funding from the NERC, the Department for Environment, Food & Rural Affairs, and the Leverhulme Trust. FB and RM are employees of The Rockefeller Foundation. SM has received funding from The Rockefeller Foundation, the Bill & Melinda Gates Foundation, the Winslow Foundation, and the Wellcome Trust for research into the human health impacts of global environmental change. DY is senior vice president of the Vitality Group, part of Discovery Ltd, where he leads the Vitality Institute. Previously, he was senior vice president of Global Health and Agriculture Policy at PepsiCo and head of global health at The Rockefeller Foundation. SN is also a member of the Lancet Commission on Pain and Palliative Care and is (as president and founder of Heartfile) a recipient of a grant from The Rockefeller Foundation. JV is a former employee of The Rockefeller Foundation. HF was a resident at The Rockefeller Foundation, Bellagio Center during March, 2015, and has previously received funding from The Rockefeller Foundation. HF is a board member of the Bullitt Foundation and the Washington Global Health Alliance. SAO (through WCS and HEAL) has received funding from The Rockefeller Foundation. The other authors declare no competing interests. NR 426 TC 58 Z9 59 U1 38 U2 110 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD NOV 14 PY 2015 VL 386 IS 10007 BP 1973 EP 2028 DI 10.1016/S0140-6736(15)60901-1 PG 56 WC Medicine, General & Internal SC General & Internal Medicine GA CW1PI UT WOS:000364763200032 PM 26188744 ER PT J AU Henson, MW Domingo, JWS Kourtev, PS Jensen, RV Dunn, JA Learman, DR AF Henson, Michael W. Domingo, Jorge W. Santo Kourtev, Peter S. Jensen, Roderick V. Dunn, James A. Learman, Deric R. TI Metabolic and genomic analysis elucidates strain-level variation in Microbacterium spp. isolated from chromate contaminated sediment SO PEERJ LA English DT Article DE Microbacterium; Chromium reduction; Strain-level variation ID HEXAVALENT CHROMIUM; PROCHLOROCOCCUS ECOTYPES; PSEUDOMONAS-PUTIDA; ESCHERICHIA-COLI; HEAVY-METALS; REDUCTION; SEQUENCE; SOIL; RESISTANCE; BACTERIUM AB Hexavalent chromium [Cr(VI)] is a soluble carcinogen that has caused widespread contamination of soil and water in many industrial nations. Bacteria have the potential to aid remediation as certain strains can catalyze the reduction of Cr(VI) to insoluble and less toxic Cr(III). Here, we examine Cr(VI) reducing Microbacterium spp. (Cr-K1W, Cr-K20, Cr-K29, and Cr-K32) isolated from contaminated sediment (Seymore, Indiana) and show varying chromate responses despite the isolates' phylogenetic similarity (i.e., identical 16S rRNA gene sequences). Detailed analysis identified differences based on genomic metabolic potential, growth and general metabolic capabilities, and capacity to resist and reduce Cr(VI). Taken together, the discrepancies between the isolates demonstrate the complexity inter-strain variation can have on microbial physiology and related biogeochemical processes. C1 [Henson, Michael W.; Dunn, James A.; Learman, Deric R.] Cent Michigan Univ, Inst Great Lakes Res, Mt Pleasant, MI 48859 USA. [Henson, Michael W.; Kourtev, Peter S.; Dunn, James A.; Learman, Deric R.] Cent Michigan Univ, Dept Biol, Mt Pleasant, MI 48859 USA. [Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Jensen, Roderick V.] Virginia Polytech Inst & State Univ, Dept Biol Sci, Virginia Tech, Blacksburg, VA 24061 USA. RP Learman, DR (reprint author), Cent Michigan Univ, Inst Great Lakes Res, Mt Pleasant, MI 48859 USA. EM deric.learman@cmich.edu OI Henson, Michael/0000-0002-4351-797X FU Central Michigan University's College of Science and Technology, Department of Biology; Central Michigan University's College of Science and Technology, Department of Earth and Atmospheric Sciences FX This work was supported by the Central Michigan University's College of Science and Technology, Department of Biology, and the Department of Earth and Atmospheric Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 66 TC 1 Z9 1 U1 3 U2 12 PU PEERJ INC PI LONDON PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND SN 2167-8359 J9 PEERJ JI PeerJ PD NOV 10 PY 2015 VL 3 AR e1395 DI 10.7717/peerj.1395 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX6HZ UT WOS:000365803100007 PM 26587353 ER PT J AU Varughese, EA Kasper, S Anneken, EM Yadav, JS AF Varughese, Eunice A. Kasper, Susan Anneken, Emily M. Yadav, Jagjit S. TI SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells SO PLOS ONE LA English DT Article ID TYROSINE-PHOSPHATASE SHP-2; FOCAL ADHESION KINASE; IN-VITRO; INCREASED EXPRESSION; CELLULAR INVASION; PROTEIN; PAXILLIN; SRC; PHOSPHORYLATION; ACTIVATION AB The parasite, Cryptosporidium parvum, induces human gastroenteritis through infection of host epithelial cells in the small intestine. During the initial stage of infection, C. parvum is reported to engage host mechanisms at the host cell-parasite interface to form a parasitophorous vacuole. We determined that upon infection, the larger molecular weight proteins in human small intestinal epithelial host cells (FHs 74 Int) appeared to globally undergo tyrosine dephosphorylation. In parallel, expression of the cytoplasmic protein tyrosine phosphatase Src homology-2 domain-containing phosphatase 2 (SHP-2) increased in a time-dependent manner. SHP-2 co-localized with the C. parvum sporozoite and this interaction increased the rate of C. parvum infectivity through SH2-mediated SHP-2 activity. Furthermore, we show that one potential target that SHP-2 acts upon is the focal adhesion protein, paxillin, which undergoes moderate dephosphorylation following infection, with inhibition of SHP-2 rescuing paxillin phosphorylation. Importantly, treatment with an inhibitor to SHP-2 and with an inhibitor to paxillin and Src family kinases, effectively decreased the multiplicity of C. parvum infection in a dose-dependent manner. Thus, our study reveals an important role for SHP-2 in the pathogenesis of C. parvum. Furthermore, while host proteins can be recruited to participate in the development of the electron dense band at the host cell-parasite interface, our study implies for the first time that SHP-2 appears to be recruited by the C. parvum sporozoite to regulate infectivity. Taken together, these findings suggest that SHP-2 and its down-stream target paxillin could serve as targets for intervention. C1 [Varughese, Eunice A.; Kasper, Susan; Yadav, Jagjit S.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Environm Genet & Mol Toxicol, Cincinnati, OH 45267 USA. [Varughese, Eunice A.; Anneken, Emily M.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Varughese, EA (reprint author), Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Environm Genet & Mol Toxicol, Cincinnati, OH 45267 USA. EM varughese.eunice@epa.gov; Jagjit.yadav@uc.edu FU U.S. Environmental Protection Agency, through its Office of Research and Development; University of Cincinnati FX The research was supported by the U.S. Environmental Protection Agency, through its Office of Research and Development, and in part by the University of Cincinnati. Commercial entities had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 0 Z9 1 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 10 PY 2015 VL 10 IS 11 AR e0142219 DI 10.1371/journal.pone.0142219 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CV7CT UT WOS:000364430700069 PM 26556238 ER PT J AU Brown, MT Campbell, DE Tilley, DR AF Brown, Mark T. Campbell, Daniel E. Tilley, David R. TI Emergy Synthesis 8 similar to Emergy and environmental accounting: Theories, applications, and methodologies SO ECOLOGICAL MODELLING LA English DT Editorial Material C1 [Brown, Mark T.] Univ Florida, Howard T Odum Ctr Wetlands, Gainesville, FL 32611 USA. [Brown, Mark T.] Univ Florida, Ctr Environm Policy, Phelps Lab 100, Gainesville, FL 32611 USA. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Tilley, David R.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. RP Brown, MT (reprint author), Univ Florida, Howard T Odum Ctr Wetlands, Museum Rd, Gainesville, FL 32611 USA. EM mtb@ufl.edu; Campbell.Dan@epa.gov; dtilley@umd.edu NR 13 TC 2 Z9 2 U1 4 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD NOV 10 PY 2015 VL 315 SI SI BP 1 EP 3 DI 10.1016/j.ecolmodel.2015.08.018 PG 3 WC Ecology SC Environmental Sciences & Ecology GA CU2KK UT WOS:000363352200001 ER PT J AU Morandi, F Campbell, DE Pulselli, FM Bastianoni, S AF Morandi, Fabiana Campbell, Daniel E. Pulselli, Federico M. Bastianoni, Simone TI Emergy evaluation of hierarchically nested systems: application to EU27, Italy and Tuscany and consequences for the meaning of emergy indicators SO ECOLOGICAL MODELLING LA English DT Article DE Hierarchical emergy evaluation; Set theory; EU27; Italy; Tuscany ID ENERGY ANALYSIS; SET-THEORY; SUSTAINABILITY; FARMS; VIEW AB What is the role of a system's size in an emergy evaluation, when we have to evaluate nested systems? To answer this question, we consider a simple nested system with three levels of organization and then examine the relationships among the emergy flows at each level and among the indicators derived from these flows. As an example of nested systems with three levels of organization, we consider a nested territorial system that is European Union-Italy-Tuscany. In particular, this system is analyzed as Italy within the European Union and Tuscany within Italy. The emergy evaluation of each hierarchical pair of system levels is presented using a new method based on set theory and, moreover, each level is analyzed as an independent system. This "double analysis" is necessary because the emergy indicators obtained for each level, are analyzed and compared to show the differences that appear when the system under study is considered as part of the larger system that contains it. In this work, data analysis shows that the set of imported flows changes its cardinality when changing the level in the hierarchically organization. In particular, with respect to EU27 and Italy, it emerges that Tuscany has a very high Environmental Loading Ratio (ELR), while EU27 has the lower value both for the Emergy Investment Ratio (EIR) and for the Emergy Yeld Ratio (EYR). It means that in Tuscany there is a big pressure on ecosystems from non-renewable flows while, in general, the EU27 might be a good place for future economic investments. (C) 2015 Elsevier B.V. All rights reserved. C1 [Morandi, Fabiana; Pulselli, Federico M.; Bastianoni, Simone] Univ Siena, Dept Earth Environm & Phys Sci, Ecodynam Grp, I-53100 Siena, Italy. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Morandi, F (reprint author), Tech Univ Denmark, Dept Chem & Biochem Engn, DK-2800 Lyngby, Denmark. EM morandi2@unisi.it RI Bastianoni, Simone/K-6721-2015 OI Bastianoni, Simone/0000-0002-6470-7377 NR 47 TC 2 Z9 2 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD NOV 10 PY 2015 VL 315 SI SI BP 12 EP 27 DI 10.1016/j.ecolmodel.2015.04.001 PG 16 WC Ecology SC Environmental Sciences & Ecology GA CU2KK UT WOS:000363352200003 ER PT J AU Schwartz, JD Lee, M Kinney, PL Yang, SJ Mills, D Sarofim, MC Jones, R Streeter, R St Juliana, A Peers, J Horton, RM AF Schwartz, Joel D. Lee, Mihye Kinney, Patrick L. Yang, Suijia Mills, David Sarofim, Marcus C. Jones, Russell Streeter, Richard St Juliana, Alexis Peers, Jennifer Horton, Radley M. TI Projections of temperature-attributable premature deaths in 209 US cities using a cluster-based Poisson approach SO ENVIRONMENTAL HEALTH LA English DT Article DE Temperature-attributable premature mortality; United States; Climate change ID HEAT-RELATED MORTALITY; EASTERN UNITED-STATES; CLIMATE-CHANGE; NEW-YORK; IMPACTS; UNCERTAINTY; ADAPTATION; EXPOSURE; WEATHER; WAVES AB Background: A warming climate will affect future temperature-attributable premature deaths. This analysis is the first to project these deaths at a near national scale for the United States using city and month-specific temperature-mortality relationships. Methods: We used Poisson regressions to model temperature-attributable premature mortality as a function of daily average temperature in 209 U.S. cities by month. We used climate data to group cities into clusters and applied an Empirical Bayes adjustment to improve model stability and calculate cluster-based month-specific temperature-mortality functions. Using data from two climate models, we calculated future daily average temperatures in each city under Representative Concentration Pathway 6.0. Holding population constant at 2010 levels, we combined the temperature data and cluster-based temperature-mortality functions to project city-specific temperature-attributable premature deaths for multiple future years which correspond to a single reporting year. Results within the reporting periods are then averaged to account for potential climate variability and reported as a change from a 1990 baseline in the future reporting years of 2030, 2050 and 2100. Results: We found temperature-mortality relationships that vary by location and time of year. In general, the largest mortality response during hotter months (April -September) was in July in cities with cooler average conditions. The largest mortality response during colder months (October-March) was at the beginning (October) and end (March) of the period. Using data from two global climate models, we projected a net increase in premature deaths, aggregated across all 209 cities, in all future periods compared to 1990. However, the magnitude and sign of the change varied by cluster and city. Conclusions: We found increasing future premature deaths across the 209 modeled U.S. cities using two climate model projections, based on constant temperature-mortality relationships from 1997 to 2006 without any future adaptation. However, results varied by location, with some locations showing net reductions in premature temperature-attributable deaths with climate change. C1 [Schwartz, Joel D.; Lee, Mihye] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Schwartz, Joel D.; Lee, Mihye] Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA. [Kinney, Patrick L.; Yang, Suijia] Columbia Univ, Mailman Sch Publ Hlth, Columbia Climate & Hlth Program, New York, NY USA. [Mills, David; Jones, Russell; Streeter, Richard; St Juliana, Alexis; Peers, Jennifer] Abt Associates Inc, Boulder, CO 80302 USA. [Sarofim, Marcus C.] US EPA, Climate Change Div, Washington, DC 20460 USA. [Horton, Radley M.] Columbia Univ, Ctr Climate Syst Res, New York, NY USA. RP Mills, D (reprint author), Abt Associates Inc, 1881 Ninth St,Suite 201, Boulder, CO 80302 USA. EM dmills@stratusconsulting.com FU U.S. EPA Climate Change Division [EP-PA-12-H-0024, EP-B14-H00008]; Stratus Consulting FX The authors thank Neal Fann and Philip Morefield of U.S. EPA for their contributions with the BenMAP model and ICLUS population data respectively. The U.S. EPA Climate Change Division provided funding for this research through contract EP-PA-12-H-0024 and order number EP-B14-H00008 with Stratus Consulting. The views expressed in this document are solely those of the authors and do not necessarily reflect those of their affiliated institutions, including the U.S. EPA. NR 34 TC 1 Z9 1 U1 2 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD NOV 4 PY 2015 VL 14 AR 85 DI 10.1186/s12940-015-0071-2 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CV2WG UT WOS:000364117600001 PM 26537962 ER PT J AU Hertzberg, RC Pan, Y Li, R Haber, LT Lyles, RH Herr, DW Moser, VC Simmons, JE AF Hertzberg, Richard C. Pan, Yi Li, Ruosha Haber, Lynne T. Lyles, Robert H. Herr, David W. Moser, Virginia C. Simmons, Jane Ellen TI A four-step approach to evaluate mixtures for consistency with dose addition (vol 313, pg 134, 2013) SO TOXICOLOGY LA English DT Correction C1 [Hertzberg, Richard C.] Biomath Consulting, Atlanta, GA 30307 USA. [Pan, Yi; Li, Ruosha; Lyles, Robert H.] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA. [Haber, Lynne T.] TERA, Cincinnati, OH 45211 USA. [Herr, David W.; Moser, Virginia C.; Simmons, Jane Ellen] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA. RP Hertzberg, RC (reprint author), Biomath Consulting, 1932 Grist Stone Court NE, Atlanta, GA 30307 USA. EM hertzberg_rc@bellsouth.net NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD NOV 4 PY 2015 VL 337 BP 108 EP 108 DI 10.1016/j.tox.2015.03.009 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CU8VF UT WOS:000363821500012 ER PT J AU Ranson, M Cox, B Keenan, C Teitelbaum, D AF Ranson, Matthew Cox, Brendan Keenan, Cheryl Teitelbaum, Daniel TI The Impact of Pollution Prevention on Toxic Environmental Releases from U.S. Manufacturing Facilities SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID WASTE REDUCTION; PROGRAMS AB Between 1991 and 2012, the facilities that reported to the U.S. Environmental Protection Agency's Toxic Release Inventory (TRI) Program conducted 370 000 source reduction projects. We use this data set to conduct the first quasi-experimental retrospective evaluation of how implementing a source reduction (pollution prevention) project affects the quantity of toxic chemicals released to the environment by an average industrial facility. We use a differences-in-differences methodology, which measures how implementing a source reduction project affects a facility's releases of targeted chemicals, relative to releases of (a) other untargeted chemicals from the same facility, or (b) the same chemical from other facilities in the same industry. We find that the average source reduction project causes a 9-16% decrease in releases of targeted chemicals in the year of implementation. Source reduction techniques vary in effectiveness: for example, raw material modification causes a large decrease in releases, while inventory control has no detectable effect. Our analysis suggests that in aggregate, the source reduction projects carried out in the U.S. since 1991 have prevented between 5 and 14 billion pounds of toxic releases. C1 [Ranson, Matthew; Cox, Brendan; Keenan, Cheryl] Abt Associates Inc, Cambridge, MA 02138 USA. [Teitelbaum, Daniel] US EPA, Tox Release Inventory Program, Washington, DC 20460 USA. RP Ranson, M (reprint author), Abt Associates Inc, 55 Wheeler St, Cambridge, MA 02138 USA. EM matthew_ranson@abtassoc.com FU U.S. Environmental Protection Agency [GS-10F-0086K] FX The work described herein was supported by the U.S. Environmental Protection Agency under contract GS-10F-0086K. The views expressed herein are solely those of the authors, and do not necessarily reflect those of U.S. EPA or Abt Associates. We thank Anna Belova, Steve DeVito, Stephen Kennedy, Annelise Mesler, Barry Nussbaum, and seminar participants at Abt Associates, the TRI National Training Conference, and U.S. EPA's TRI P2 Workgroup for helpful suggestions. NR 17 TC 5 Z9 6 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 3 PY 2015 VL 49 IS 21 BP 12951 EP 12957 DI 10.1021/acs.est.5b02367 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CV6BI UT WOS:000364355300040 PM 26477531 ER PT J AU George, IJ Hays, MD Herrinton, JS Preston, W Snow, R Faircloth, J George, BJ Long, T Baldauf, RW AF George, Ingrid J. Hays, Michael D. Herrinton, Jason S. Preston, William Snow, Richard Faircloth, James George, Barbara Jane Long, Thomas Baldauf, Richard W. TI Effects of Cold Temperature and Ethanol Content on VOC Emissions from Light-Duty Gasoline Vehicles SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID UNITED-STATES; GASEOUS EMISSIONS; START EMISSIONS; FUEL; E85; IMPACTS; BLENDS; ISOBUTANOL; COMPONENTS AB Emissions of speciated volatile organic compounds (VOCs), including mobile source air toxics (MSATs), were measured in vehicle exhaust from three light-duty spark ignition vehicles operating on summer and winter grade gasoline (E0) and ethanol blended (E10 and E85) fuels. Vehicle testing was conducted using a three-phase LA92 driving cycle in a temperature-controlled chassis dynamometer at two ambient temperatures (-7 and 24 degrees C). The cold start driving phase and cold ambient temperature increased VOC and MSAT emissions up to several orders of magnitude compared to emissions during other vehicle operation phases and warm ambient temperature testing, respectively. As a result, calculated ozone formation potentials (OFPs) were 7 to 21 times greater for the cold starts during cold temperature tests than comparable warm temperature tests. The use of E85 fuel generally led to substantial reductions in hydrocarbons and increases in oxygenates such as ethanol and acetaldehyde compared to E0 and E10 fuels. However, at the same ambient temperature, the VOC emissions from the E0 and E10 fuels and OFPs from all fuels were not significantly different. Cold temperature effects on cold start MSAT emissions varied by individual MSAT compound, but were consistent over a range of modem spark ignition vehicles. C1 [George, Ingrid J.; Hays, Michael D.; Herrinton, Jason S.; Snow, Richard; Faircloth, James; Long, Thomas; Baldauf, Richard W.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Preston, William] ARCADIS US Inc, Res Triangle Pk, NC 27711 USA. [George, Barbara Jane] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Hays, MD (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM hays.michael@epa.gov NR 31 TC 3 Z9 3 U1 15 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 3 PY 2015 VL 49 IS 21 BP 13067 EP 13074 DI 10.1021/acs.est.5b04102 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CV6BI UT WOS:000364355300053 PM 26444830 ER PT J AU Morgan, MK Jones, PA Sobus, JR Chuang, JC Wilson, NK AF Morgan, Marsha K. Jones, Paul A. Sobus, Jon R. Chuang, Jane C. Wilson, Nancy K. TI Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH LA English DT Article DE biomarker; pyrene; exposure; 1-hydroxypyrene; Ohio ID PERSISTENT ORGANIC POLLUTANTS; US POPULATION; EVERYDAY ENVIRONMENTS; AGGREGATE EXPOSURES; PAH EXPOSURE; DAY-CARE; 1-HYDROXYPYRENE; METABOLITES AB Limited data exist on exposures of young children to polycyclic aromatic hydrocarbons (PAHs) in the United States (US). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHPyr), is widely used as a biomarker of total PAH exposure. Our objectives were to quantify urinary 1-OHPyr levels in 126 preschool children over a 48-h period and to examine associations between selected sociodemographic/lifestyle factors and urinary 1-OHPyr levels. Monitoring was performed at 126 homes and 16 daycares in Ohio in 2001, and questionnaires and urine samples were collected. The median urinary 1-OHPyr level was 0.33 ng/mL. In a multiple regression model, sampling season (p = 0.0001) and natural log (ln)-transformed creatinine concentration (p = 0.0006) were highly significant predictors of ln-transformed 1-OH-Pyr concentration; cooking appliance type (p = 0.096) was a marginally significant predictor of ln(1-OHPyr). These children had higher median urinary 1-OHPyr levels compared to other US children (<= 0.15 ng/mL) in previously published studies, which suggests possible geographical differences in PAH exposure. C1 [Morgan, Marsha K.; Jones, Paul A.; Sobus, Jon R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Chuang, Jane C.] Battelle Mem Inst, Columbus, OH USA. [Wilson, Nancy K.] Battelle Mem Inst, Durham, NC USA. RP Morgan, MK (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. EM morgan.marsha@epa.gov FU United States Environmental Protection Agency through Office of Research and Development [68-D-99-011] FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under Contract # 68-D-99-011 to Battelle. It has been subjected to Agency review and approved for publication. NR 34 TC 2 Z9 2 U1 0 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0960-3123 EI 1369-1619 J9 INT J ENVIRON HEAL R JI Int. J. Environ. Health Res. PD NOV 2 PY 2015 VL 25 IS 6 BP 628 EP 639 DI 10.1080/09603123.2014.1003039 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CT2QO UT WOS:000362648500004 PM 25614176 ER PT J AU DeMessie, B Sahle-Demessie, E Sorial, GA AF DeMessie, Bluye Sahle-Demessie, E. Sorial, George A. TI Cleaning Water Contaminated with Heavy Metal Ions Using Pyrolyzed Biochar Adsorbents SO SEPARATION SCIENCE AND TECHNOLOGY LA English DT Article DE heavy metal; pyrolyzed banana peel; adsorption equilibrium; kinetics ID AQUEOUS-SOLUTION; WASTE-WATER; RICE HUSK; REMOVAL; BIOSORPTION; ADSORPTION; SORPTION; BANANA; RESIDUES; CR(III) AB The extraction of pollutants from water using activated biochar materials is a low cost, sustainable approach for providing safe water in developing countries. The adsorption of copper ions, Cu(II), onto pyrolyzed and activated dried banana peel was studied and compared with the adsorption of copper ions onto a commercial activated carbon, F-400. Both the physical and chemical properties of the banana peel and activated carbon were measured. Pyrolysis of dried banana peels resulted in the formation of a large, porous surface area adsorbent with strongly negative surface charges.Screening studies, which were designed to evaluate the effect of the mass of the adsorbent, pH of the solution, tumbling time, and initial Cu(II) concentration were conducted for each adsorbent. Equilibrium adsorption data were also analyzed, and the Freundlich isotherm resulted in a better fit than the Langmuir isotherm. The degree of favorability of adsorption of Cu(II) ions and adsorption capacity were 1.25 and 351.1 mg/g for pyrolyzed banana peel, respectively. The sorption kinetics fit a pseudo-second order equation. The mechanism of adsorption of metal ions on pyrolyzed banana peel followed ion exchange and electrostatic interactions resulting in the complexation of adsorbed ions. C1 [DeMessie, Bluye; Sorial, George A.] Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Environm Engn Program, Cincinnati, OH USA. [Sahle-Demessie, E.] US EPA, Off Res & Dev, NRMRL, Cincinnati, OH 45268 USA. RP Sahle-Demessie, E (reprint author), US EPA, Off Res & Dev, NRMRL, Cincinnati, OH 45268 USA. EM sahle-demessie.endalkachew@epa.gov NR 38 TC 2 Z9 2 U1 12 U2 67 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0149-6395 EI 1520-5754 J9 SEP SCI TECHNOL JI Sep. Sci. Technol. PD NOV 2 PY 2015 VL 50 IS 16 BP 2448 EP 2457 DI 10.1080/01496395.2015.1064134 PG 10 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA CT3PH UT WOS:000362718500003 ER PT J AU King, K Fillenbaum, G Cohen, HJ AF King, K. Fillenbaum, G. Cohen, H. J. TI FRAILTY AND NEIGHBORHOOD DISADVANTAGE SO GERONTOLOGIST LA English DT Meeting Abstract C1 [King, K.] US EPA, Durham, NC USA. [Fillenbaum, G.; Cohen, H. J.] Duke Univ, Med Ctr, Ctr Study Aging, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD NOV PY 2015 VL 55 SU 2 BP 282 EP 282 PG 1 WC Gerontology SC Geriatrics & Gerontology GA DJ5BV UT WOS:000374222701470 ER PT J AU Smith, L Mukerjee, S Kovalcik, K Sams, E Stallings, C Hudgens, E Scott, J Krantz, T Neas, L AF Smith, Luther Mukerjee, Shaibal Kovalcik, Kasey Sams, Elizabeth Stallings, Casson Hudgens, Edward Scott, James Krantz, Todd Neas, Lucas TI Near-road measurements for nitrogen dioxide and its association with traffic exposure zones SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Geographic information system (GIS); Land use regression (LUR); Nitrogen dioxide (NO2); Passive sampler; Traffic ID RESIDENTIAL PROXIMITY; AIR; ASTHMA; MODELS AB Near-road measurements for nitrogen dioxide (NO2) using passive air samplers were collected weekly in traffic exposure zones (TEZs) in the Research Triangle area of North Carolina (USA) during Fall 2014. Land use regression (LUR) analysis and pairwise comparisons of TEZs showed NO2 concentrations were associated with TEZs. Greater NO2 levels occurred in delay, high volume, and bus route sections versus higher signal light density, urbanized, and "remainder of study" areas. Comparison of near-road passively sampled NO2 concentrations by TEZ agreed with previous real-time on-road comparisons for NO2 in these TEZs. Copyright (c) 2015 Turkish National Committee for Air Pollution Research and Control. Production and hosting by Elsevier B.V. All rights reserved. C1 [Smith, Luther; Stallings, Casson] Alion Sci & Technol, Durham, NC USA. [Mukerjee, Shaibal; Kovalcik, Kasey] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Sams, Elizabeth; Hudgens, Edward; Scott, James; Krantz, Todd; Neas, Lucas] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Mukerjee, S (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM mukerjee.shaibal@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development [EP-D-10-070] FX We thank Ronald Williams of EPA for providing passive sampler housings and shelters and reviewing this paper. We also thank Rachelle Duvall of EPA for reviewing the paper. Finally, we thank Duke Energy for allowing use of its utility poles for this study. The authors declare no conflict of interest. The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under contract EP-D-10-070 to Alion Science and Technology. The paper has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use. NR 22 TC 0 Z9 0 U1 5 U2 7 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD NOV PY 2015 VL 6 IS 6 BP 1082 EP 1086 DI 10.1016/j.apr.2015.06.005 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA DH1ER UT WOS:000372527700020 ER PT J AU Heberling, MT Nietch, CT Thurston, HW Elovitz, M Birkenhauer, KH Panguluri, S Ramakrishnan, B Heiser, E Neyer, T AF Heberling, Matthew T. Nietch, Christopher T. Thurston, Hale W. Elovitz, Michael Birkenhauer, Kelly H. Panguluri, Srinivas Ramakrishnan, Balaji Heiser, Eric Neyer, Tim TI Comparing drinking water treatment costs to source water protection costs using time series analysis SO WATER RESOURCES RESEARCH LA English DT Article ID LAGGED DEPENDENT-VARIABLES; UNIT-ROOT; ERROR-CORRECTION; SOIL-EROSION; SERVICES; QUALITY; COINTEGRATION; EQUATIONS; DYNAMICS; PAYMENTS AB We present a framework to compare water treatment costs to source water protection costs, an important knowledge gap for drinking water treatment plants (DWTPs). This trade-off helps to determine what incentives a DWTP has to invest in natural infrastructure or pollution reduction in the watershed rather than pay for treatment on site. To illustrate, we use daily observations from 2007 to 2011 for the Bob McEwen Water Treatment Plant, Clermont County, Ohio, to understand the relationship between treatment costs and water quality and operational variables (e.g., turbidity, total organic carbon [TOC], pool elevation, and production volume). Part of our contribution to understanding drinking water treatment costs is examining both long-run and short-run relationships using error correction models (ECMs). Treatment costs per 1000 gallons (per 3.79 m(3)) were based on chemical, pumping, and granular activated carbon costs. Results from the ECM suggest that a 1% decrease in turbidity decreases treatment costs by 0.02% immediately and an additional 0.1% over future days. Using mean values for the plant, a 1% decrease in turbidity leads to $1123/year decrease in treatment costs. To compare these costs with source water protection costs, we use a polynomial distributed lag model to link total phosphorus loads, a source water quality parameter affected by land use changes, to turbidity at the plant. We find the costs for source water protection to reduce loads much greater than the reduction in treatment costs during these years. Although we find no incentive to protect source water in our case study, this framework can help DWTPs quantify the trade-offs. C1 [Heberling, Matthew T.; Thurston, Hale W.] US Environm Protect Agcy, Sustainable Technol Div, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH USA. [Nietch, Christopher T.; Elovitz, Michael] US Environm Protect Agcy, Water Supply & Water Resources Div, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH USA. [Birkenhauer, Kelly H.; Panguluri, Srinivas; Ramakrishnan, Balaji] CB&I Fed Serv LLC, Cincinnati, OH USA. [Heiser, Eric; Neyer, Tim] Clermt Cty Water Resources Dept, Batavia, OH USA. RP Heberling, MT (reprint author), US Environm Protect Agcy, Sustainable Technol Div, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH USA. EM Heberling.Matt@epa.gov NR 47 TC 2 Z9 2 U1 4 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD NOV PY 2015 VL 51 IS 11 BP 8741 EP 8756 DI 10.1002/2014WR016422 PG 16 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA DB3OC UT WOS:000368420000005 ER PT J AU Smith, RL Sengupta, D Takkellapati, S Lee, CC AF Smith, R. L. Sengupta, D. Takkellapati, S. Lee, C. C. TI An industrial ecology approach to municipal solid waste management: I. Methodology SO RESOURCES CONSERVATION AND RECYCLING LA English DT Article DE Industrial ecology; Municipal solid waste; MSW; Energy; Sustainability ID LCA AB Municipal solid waste (MSW) can be viewed as a feedstock for industrial ecology inspired conversions of wastes to valuable products and energy. The industrial ecology principle of symbiotic processes using waste streams for creating value-added products is applied to MSW, with examples suggested for various residual streams. A methodology is presented to consider individual waste-to-energy or waste-to-product system synergies, evaluating the economic and environmental issues associated with each system. Steps included in the methodology include identifying waste streams, specific waste components of interest, and conversion technologies, plus steps for determining the economic and environmental effects of using wastes and changes due to transport, administrative handling, and processing. In addition to presenting the methodology, technologies for various MSW input streams are categorized as commercialized or demonstrated to provide organizations that are considering processes for MSW with summarized information. The organization can also follow the methodology to analyze interesting processes. Published by Elsevier B.V. C1 [Smith, R. L.; Sengupta, D.; Takkellapati, S.; Lee, C. C.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. [Sengupta, D.] ORISE, Oak Ridge, TN 37830 USA. RP Smith, RL (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. EM smith.raymond@epa.gov NR 28 TC 1 Z9 1 U1 3 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-3449 EI 1879-0658 J9 RESOUR CONSERV RECY JI Resour. Conserv. Recycl. PD NOV PY 2015 VL 104 BP 311 EP 316 DI 10.1016/j.resconrec.2015.04.005 PN A PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA5SD UT WOS:000367861900030 ER PT J AU Smith, RL Sengupta, D Takkellapati, S Lee, CC AF Smith, R. L. Sengupta, D. Takkellapati, S. Lee, C. C. TI An industrial ecology approach to municipal solid waste management: II. Case studies for recovering energy from the organic fraction of MSW SO RESOURCES CONSERVATION AND RECYCLING LA English DT Article DE Industrial ecology; Municipal solid waste; MSW; Energy; Sustainability ID CONVERSION; ETHANOL; SYNGAS; FERMENTATION; PRETREATMENT AB The organic fraction of municipal solid waste provides abundant opportunities for industrial ecology-based symbiotic use. Energy production, economics, and environmental aspects are analyzed for four alternatives based on different technologies: incineration with energy recovery, gasification, anaerobic digestion, and fermentation. In these cases electricity and ethanol are the products considered, but other products and attempts at symbiosis can be made. The four technologies are in various states of commercial development. To highlight their relative complexities some adjustable parameters which are important for the operability of each process are discussed. While these technologies need to be considered for specific locations and circumstances, generalized economic and environmental information suggests relative comparisons for newly conceptualized processes. The results of industrial ecology-based analysis suggest that anaerobic digestion may improve seven emission categories, while fermentation, gasification, and incineration successively improve fewer emissions. A conceptual level analysis indicates that gasification, anaerobic digestion, and fermentation alternatives lead to positive economic results. In each case the alternatives and their assumptions need further analysis for any particular community. Published by Elsevier B.V. C1 [Smith, R. L.; Takkellapati, S.; Lee, C. C.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. [Sengupta, D.] ORISE, Oak Ridge, TN 37830 USA. RP Smith, RL (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. EM smith.raymond@epa.gov NR 60 TC 2 Z9 3 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-3449 EI 1879-0658 J9 RESOUR CONSERV RECY JI Resour. Conserv. Recycl. PD NOV PY 2015 VL 104 BP 317 EP 326 DI 10.1016/j.resconrec.2015.05.016 PN A PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA5SD UT WOS:000367861900031 ER PT J AU Geh, EN Ghosh, D McKell, M de la Cruz, AA Stelma, G Bernstein, JA AF Geh, Esmond N. Ghosh, Debajyoti McKell, Melanie de la Cruz, Armah A. Stelma, Gerard Bernstein, Jonathan A. TI Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID BLUE-GREEN-ALGAE; CYLINDROSPERMOPSIS-RACIBORSKII; MESSENGER-RNA; DIETARY-SUPPLEMENTS; IN-VITRO; PHYCOCYANIN; LR; TOXICITY; PROTEINS; HEALTH AB Background: The cyanobacterium species Microcystis aeruginosa produces microcystin and an array of diverse metabolites believed responsible for their toxicity and/or immunogenicity. Previously, chronic rhinitis patients were demonstrated to elicit a specific IgE response to nontoxic strains of M. aeruginosa by skin-prick testing, indicating that cyanobacteria allergenicity resides in a non-toxinproducing component of the organism. Objectives: We sought to identify and characterize M. aeruginosa peptide(s) responsible for allergic sensitization in susceptible individuals, and we investigated the functional interactions between cyanobacterial toxins and their coexpressed immunogenic peptides. Methods: Sera from patients and extracts from M. aeruginosa toxic [MC(+)] and nontoxic [MC(-)] strains were used to test IgE-specific reactivity by direct and indirect ELISAs; 2D gel electrophoresis, followed by immunoblots and mass spectrometry (MS), was performed to identify the relevant sensitizing peptides. Cytotoxicity and mediator release assays were performed using the MC(+) and MC() lysates. Results: We found specific IgE to be increased more in response to the MC(-) strain than the MC(+) strain. This response was inhibited by preincubation of MC(-) lysate with increasing concentrations of microcystin. MS revealed that phycocyanin and the core-membrane linker peptide are the responsible allergens, and MC(-) extracts containing these proteins induced beta-hexosaminidase release in rat basophil leukemia cells. Conclusions: Phycobiliprotein complexes in M. aeruginosa have been identified as the relevant sensitizing proteins. Our finding that allergenicity is inhibited in a dose-dependent manner by microcystin toxin suggests that further investigation is warranted to understand the interplay between immunogenicity and toxicity of cyanobacteria under diverse environmental conditions. C1 [Geh, Esmond N.; Ghosh, Debajyoti; Bernstein, Jonathan A.] Univ Cincinnati, Coll Med, Dept Internal Med, Allergy Sect,Div Immunol Allergy & Rheumatol, Cincinnati, OH 45267 USA. [Geh, Esmond N.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA. [McKell, Melanie] Miami Univ, Oxford, OH 45056 USA. [de la Cruz, Armah A.; Stelma, Gerard] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Bernstein, JA (reprint author), Univ Cincinnati, 231 Albert Sabin Way,ML 563 Room 7413, Cincinnati, OH 45267 USA. EM jonathan.bernstein@uc.edu FU National Institute of Environmental Health Sciences, National Intitutes of Health [5T32ES010640, P30-ES06090] FX This research WaS supported by National Institute of Environmental Health Sciences, National Intitutes of Health grants 5T32ES010640 and P30-ES06090. NR 45 TC 3 Z9 3 U1 1 U2 16 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2015 VL 123 IS 11 BP 1159 EP 1166 DI 10.1289/ehp.1409065 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1VW UT WOS:000367584600018 PM 25902363 ER PT J AU Tong, HY Rappold, AG Caughey, M Hinderliter, AL Bassett, M Montilla, T Case, MW Berntsen, J Bromberg, PA Cascio, WE Diaz-Sanchez, D Devlin, RB Samet, JM AF Tong, Haiyan Rappold, Ana G. Caughey, Melissa Hinderliter, Alan L. Bassett, Maryann Montilla, Tracey Case, Martin W. Berntsen, Jon Bromberg, Philip A. Cascio, Wayne E. Diaz-Sanchez, David Devlin, Robert B. Samet, James M. TI Dietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID FATTY-ACID SUPPLEMENTATION; AIR-POLLUTION; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE; DIESEL EXHAUST; CARDIOVASCULAR-DISEASE; PLASMINOGEN-ACTIVATOR; MEDITERRANEAN DIET; DYSFUNCTION; ATHEROSCLEROSIS AB BACKGROUND: Exposure to ambient particulate matter (PM) induces endothelial dysfunction, a risk factor for cardiovascular disease. Olive oil (OO) and fish oil (FO) supplements have beneficial effects on endothelial function. OBJECTIVE: In this study we evaluated the potential efficacy of OO and FO in mitigating endothelial dysfunction and disruption of hemostasis caused by exposure to particulate matter (PM). METHODS AND RESULTS: Forty-two participants (58 +/- 1 years of age) received either 3 g/day of OO or FO, or no supplements (naive) for 4 weeks prior to undergoing 2-hr exposures to filtered air and concentrated ambient particulate matter (CAP; mean, 253 +/- 16 mu g/m(3)). Endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery preexposure, immediately postexposure, and 20 hr postexposure. Levels of endothelin-1 and markers of fibrinolysis and inflammation were also measured. The FMD was significantly lower after CAP exposure in the naive (-19.4%; 95% CI: -36.4, -2.3 per 100 mu g/m(3) CAP relative to baseline; p = 0.03) and FO groups (-13.7%; 95% CI: -24.5, -2.9; p = 0.01), but not in the OO group (-7.6%; 95% CI: -21.5, 6.3; p = 0.27). Tissue plasminogen activator levels were significantly increased immediately after (11.6%; 95% CI: 0.8, 22.2; p = 0.04) and 20 hr after CAP exposure in the OO group. Endothelin-1 levels were significantly increased 20 hr after CAP exposure in the naive group only (17.1%; 95% CI: 2.2, 32.0; p = 0.03). CONCLUSIONS: Short-term exposure to CAP induced vascular endothelial dysfunction. OO supplementation attenuated CAP-induced reduction of FMD and changes in blood markers associated with vasoconstriction and fibrinolysis, suggesting that OO supplementation may be an efficacious intervention to protect against vascular effects of exposure to PM. C1 [Tong, Haiyan; Rappold, Ana G.; Bassett, Maryann; Montilla, Tracey; Case, Martin W.; Cascio, Wayne E.; Diaz-Sanchez, David; Devlin, Robert B.; Samet, James M.] US EPA, Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27709 USA. [Caughey, Melissa; Hinderliter, Alan L.; Bromberg, Philip A.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Berntsen, Jon] TRC Environm Corp, Raleigh, NC USA. RP Tong, HY (reprint author), US EPA, Publ Hlth Div, NHEERL, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM tong.haiyan@epa.gov FU U.S. Environmental Protection Agency Intrmaural Reserach Program; National Institutes of Health [RR00046] FX The U.S. Environmental Protection Agency Intrmaural Reserach Program supported this research. This project is supported in part by National Institutes of Health grant RR00046 to the UNC-Chapel Hill Clinical and Translational Research Center. J.H.B. is employed by TRC Environmental Corporation. NR 42 TC 3 Z9 3 U1 2 U2 9 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2015 VL 123 IS 11 BP 1173 EP 1179 DI 10.1289/ehp.1408988 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1VW UT WOS:000367584600020 PM 25933197 ER PT J AU Bell, SM Edwards, SW AF Bell, Shannon M. Edwards, Stephen W. TI Identification and Prioritization of Relationships between Environmental Stressors and Adverse Human Health Impacts SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID FALSE DISCOVERY RATE; ASSOCIATION; CHEMICALS AB Background: There are > 80,000 chemicals in commerce with few data available describing their impacts on human health. Biomonitoring surveys, such as the NHANES (National Health and Nutrition Examination Survey), offer one route to identifying possible relationships between environmental chemicals and health impacts, but sparse data and the complexity of traditional models make it difficult to leverage effectively. Objective: We describe a workflow to efficiently and comprehensively evaluate and prioritize chemicalhealth impact relationships from the NHANES biomonitoring survey studies. Methods: Using a frequent itemset mining (FIM) approach, we identified relationships between chemicals and health biomarkers and diseases. Results: The FIM method identified 7,848 relationships between 219 chemicals and 93 health outcomes/biomarkers. Two case studies used to evaluate the FIM rankings demonstrate that the FIM approach is able to identify published relationships. Because the relationships are derived from the vast majority of the chemicals monitored by NHANES, the resulting list of associations is appropriate for evaluating results from targeted data mining or identifying novel candidate relationships for more detailed investigation. Conclusions: Because of the computational efficiency of the FIM method, all chemicals and health effects can be considered in a single analysis. The resulting list provides a comprehensive summary of the chemical/health co-occurrences from NHANES that are higher than expected by chance. This information enables ranking and prioritization on chemicals or health effects of interest for evaluation of published results and design of future studies. C1 [Bell, Shannon M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Bell, Shannon M.; Edwards, Stephen W.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Edwards, SW (reprint author), US EPA, 109 TW Alexander Dr,Mail Code B105-01, Res Triangle Pk, NC 27709 USA. EM edwards.stephen@epa.gov FU U. S. Environmental Protection Agency (EPA); Internship/Research Participation Program at the Office of Research and Development, U.S. EPA FX The information in this document was funded wholly by the U. S. Environmental Protection Agency (EPA). S.M.B was supported by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. EPA, administrered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. NR 24 TC 4 Z9 4 U1 1 U2 6 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2015 VL 123 IS 11 BP 1193 EP 1199 DI 10.1289/ehp.1409138 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1VW UT WOS:000367584600023 PM 25859761 ER PT J AU Langley, G Austin, CP Balapure, AK Birnbaum, LS Bucher, JR Fentem, J Fitzpatrick, SC Fowle, JR Kavlock, RJ Kitano, H Lidbury, BA Muotri, AR Peng, SQ Sakharov, D Seidle, T Trez, T Tonevitsky, A van De Stolpe, A Whelan, M Willett, C AF Langley, Gill Austin, Christopher P. Balapure, Anil K. Birnbaum, Linda S. Bucher, John R. Fentem, Julia Fitzpatrick, Suzanne C. Fowle, John R. Kavlock, Robert J. Kitano, Hiroaki Lidbury, Brett A. Muotri, Alysson R. Peng, Shuang-Qing Sakharov, Dmitry Seidle, Troy Trez, Thales Tonevitsky, Alexander van de Stolpe, Anja Whelan, Maurice Willett, Catherine TI Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE; MODELS; PATHWAYS; PROTEIN AB Biomedical developments in the 21st century provide an unprecedented opportunity to gain a dynamic systems-level and human-specific understanding of the causes and pathophysiologies of disease. This understanding is a vital need, in view of continuing failures in health research, drug discovery, and clinical translation. The full potential of advanced approaches may not be achieved within a 20th-century conceptual framework dominated by animal models. Novel technologies are being integrated into environmental health research and are also applicable to disease research, but these advances need a new medical research and drug discovery paradigm to gain maximal benefits. We suggest a new conceptual framework that repurposes the 21st-century transition underway in toxicology. Human disease should be conceived as resulting from integrated extrinsic and intrinsic causes, with research focused on modern human-specific models to understand disease pathways at multiple biological levels that are analogous to adverse outcome pathways in toxicology. Systems biology tools should be used to integrate and interpret data about disease causation and pathophysiology. Such an approach promises progress in overcoming the current roadblocks to understanding human disease and successful drug discovery and translation. A discourse should begin now to identify and consider the many challenges and questions that need to be solved. C1 [Langley, Gill] Humane Soc Int, Res & Toxicol Dept, London N1 7LY, England. [Austin, Christopher P.] NIH, Natl Ctr Adv Translat Sci, US Dept HHS, Bethesda, MD 20892 USA. [Balapure, Anil K.] CSIR Cent Drug Res Inst, Div Biochem, Lucknow, Uttar Pradesh, India. [Birnbaum, Linda S.] NIEHS, Res Triangle Pk, NC 27709 USA. [Birnbaum, Linda S.] NIH, NTP, DHHS, Res Triangle Pk, NC USA. [Bucher, John R.] NIEHS, Div NTP, NIH, DHHS, Res Triangle Pk, NC 27709 USA. [Fentem, Julia] Unilever R&D, SEAC, Sharnbrook, Beds, England. [Fitzpatrick, Suzanne C.] US FDA, Off Ctr Director, Ctr Food Safety & Appl Nutr, Rockville, MD 20857 USA. [Fowle, John R.] Sci Inform LLC, Pittsboro, NC USA. [Kavlock, Robert J.] US EPA, Off Res & Dev, Washington, DC 20460 USA. [Kitano, Hiroaki] Syst Biol Inst, Tokyo, Japan. [Lidbury, Brett A.] Australian Natl Univ, John Curtin Sch Med Res, Genom & Predict Med, Canberra, ACT 2601, Australia. [Muotri, Alysson R.] Univ Calif San Diego, Sch Med, Dept Pediat, Rady Childrens Hosp San Diego,Dept Cellular & Mol, La Jolla, CA 92093 USA. [Peng, Shuang-Qing] Acad Mil Med Sci, Inst Dis Control & Prevent, Evaluat & Res Ctr Toxicol, Beijing, Peoples R China. [Sakharov, Dmitry] Sci Res Ctr Bioclinicum, Moscow, Russia. [Seidle, Troy] Humane Soc Int, Res & Toxicol Dept, Montreal, PQ, Canada. [Trez, Thales] Univ Fed Alfenas, Inst Sci & Technol, Alfenas, Brazil. [Tonevitsky, Alexander] Natl Ctr Med Radiol Res, Obninsk, Russia. [van de Stolpe, Anja] Philips Res, Eindhoven, Netherlands. [Whelan, Maurice] Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21020 Ispra, Italy. [Willett, Catherine] Humane Soc United States, Regulatory Toxicol Risk Assessment & Alternat, Washington, DC USA. RP Langley, G (reprint author), Humane Soc Int, 5 Underwood St, London N1 7LY, England. EM glangley@hsi.org OI Seidle, Troy/0000-0002-1341-2181; Tonevitsky, Alexander/0000-0002-7079-7145 NR 41 TC 11 Z9 12 U1 6 U2 9 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2015 VL 123 IS 11 BP A268 EP A272 DI 10.1289/ehp.1510345 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DA1VW UT WOS:000367584600001 PM 26523530 ER PT J AU Turner, MD Henze, DK Capps, SL Hakami, A Zhao, SL Resler, J Carmichael, GR Stanier, CO Baek, J Sandu, A Russell, AG Nenes, A Pinder, RW Napelenok, SL Bash, JO Percell, PB Chai, TF AF Turner, Matthew D. Henze, Daven K. Capps, Shannon L. Hakami, Amir Zhao, Shunliu Resler, Jaroslav Carmichael, Gregory R. Stanier, Charles O. Baek, Jaemeen Sandu, Adrian Russell, Armistead G. Nenes, Athanasios Pinder, Rob W. Napelenok, Sergey L. Bash, Jesse O. Percell, Peter B. Chai, Tianfeng TI Premature deaths attributed to source-specific BC emissions in six urban US regions SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Article DE source attribution; particulate matter; aerosols; air quality; human well-being ID ADJOINT SENSITIVITY-ANALYSIS; PARTICULATE AIR-POLLUTION; HEART-RATE-VARIABILITY; LONG-TERM EXPOSURE; BLACK CARBON; UNITED-STATES; HUMAN MORTALITY; HEALTH IMPACTS; BLOOD-PRESSURE; GLOBAL BURDEN AB Recent studies have shown that exposure to particulate black carbon (BC) has significant adverse health effects and may be more detrimental to human health than exposure to PM2.5 as a whole. Mobile source BC emission controls, mostly on diesel-burning vehicles, have successfully decreased mobile source BC emissions to less than half of what they were 30 years ago. Quantification of the benefits of previous emissions controls conveys the value of these regulatory actions and provides a method by which future control alternatives could be evaluated. In this study we use the adjoint of the Community Multiscale Air Quality (CMAQ) model to estimate highly-resolved spatial distributions of benefits related to emission reductions for six urban regions within the continental US. Emissions from outside each of the six chosen regions account for between 7% and 27% of the premature deaths attributed to exposure to BC within the region. While we estimate that nonroad mobile and onroad diesel emissions account for the largest number of premature deaths attributable to exposure to BC, onroad gasoline is shown to have more than double the benefit per unit emission relative to that of nonroad mobile and onroad diesel. Within the region encompassing New York City and Philadelphia, reductions in emissions from large industrial combustion sources that are not classified as EGUs (i.e., non-EGU) are estimated to have up to triple the benefits per unit emission relative to reductions to onroad diesel sectors, and provide similar benefits per unit emission to that of onroad gasoline emissions in the region. While onroad mobile emissions have been decreasing in the past 30 years and a majority of vehicle emission controls that regulate PM focus on diesel emissions, our analysis shows the most efficient target for stricter controls is actually onroad gasoline emissions. C1 [Turner, Matthew D.; Henze, Daven K.; Capps, Shannon L.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. [Hakami, Amir; Zhao, Shunliu] Carleton Univ, Dept Civil & Environm Engn, Ottawa, ON K1S 5B6, Canada. [Resler, Jaroslav] Inst Comp Sci, Nonlinear Modeling, Prague 18207, Czech Republic. [Carmichael, Gregory R.; Stanier, Charles O.; Baek, Jaemeen] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA. [Sandu, Adrian] Virginia Tech, Comp Sci, Blacksburg, VA 24061 USA. [Russell, Armistead G.] Georgia Tech, Sch Civil & Environm Engn, Atlanta, GA 30331 USA. [Nenes, Athanasios] Georgia Tech, Sch Earth & Atmospher Sci, Atlanta, GA 30331 USA. [Pinder, Rob W.; Napelenok, Sergey L.; Bash, Jesse O.] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. [Percell, Peter B.] Univ Houston, Dept Geosci, Houston, TX 77004 USA. [Chai, Tianfeng] Univ Maryland, Coll Comp Math & Nat Sci, College Pk, MD 20742 USA. RP Turner, MD (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. EM matthew.d.turner@colorado.edu RI Resler, Jaroslav/E-6097-2014; Stanier, Charles/D-4307-2016; Chai, Tianfeng/E-5577-2010; Capps, Shannon/E-5602-2017; OI Stanier, Charles/0000-0001-9924-0853; Chai, Tianfeng/0000-0003-3520-2641; Capps, Shannon/0000-0002-6872-6604; Bash, Jesse/0000-0001-8736-0102 FU NASA Applied Sciences Program [NNX09AN77G]; Research Participation Program at the Office of Research and Development, US EPA FX This research was supported by NASA Applied Sciences Program grant NNX09AN77G. This paper has been subjected to the United States Environmental Protection Agency's administrative review and approved for publication but solely reflects the views of the authors. Shannon L Capps was supported by an appointment to the Research Participation Program at the Office of Research and Development, US EPA, administered by ORISE. NR 65 TC 2 Z9 2 U1 8 U2 29 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD NOV PY 2015 VL 10 IS 11 AR 114014 DI 10.1088/1748-9326/10/11/114014 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ6ZO UT WOS:000367249900018 ER PT J AU Blamey, FPC Hernandez-Soriano, MC Cheng, MM Tang, CX Paterson, DJ Lombi, E Wang, WH Scheckel, KG Kopittke, PM AF Blamey, F. Pax C. Hernandez-Soriano, Maria C. Cheng, Miaomiao Tang, Caixian Paterson, David J. Lombi, Enzo Wang, Wei Hong Scheckel, Kirk G. Kopittke, Peter M. TI Synchrotron-Based Techniques Shed Light on Mechanisms of Plant Sensitivity and Tolerance to High Manganese in the Root Environment SO PLANT PHYSIOLOGY LA English DT Article ID RAY-ABSORPTION SPECTROSCOPY; FLUORESCENCE MICROSCOPY; CALLOSE FORMATION; MN ACCUMULATION; HYDRATED ROOTS; METAL-IONS; TOXICITY; COWPEA; SPECIATION; NICKEL AB Plant species differ in response to high available manganese (Mn), but the mechanisms of sensitivity and tolerance are poorly understood. In solution culture, greater than or equal to 30 mu M Mn decreased the growth of soybean (Glycine max), but white lupin (Lupinus albus), narrow-leafed lupin (Lupin angustifolius), and sunflower (Helianthus annuus) grew well at 100 mM Mn. Differences in species' tolerance to high Mn could not be explained simply by differences in root, stem, or leaf Mn status, being 8.6, 17.1, 6.8, and 9.5 mmol kg(-1) leaf fresh mass at 100 mM Mn. Furthermore, x-ray absorption near edge structure analyses identified the predominance of Mn(II), bound mostly to malate or citrate, in roots and stems of all four species. Rather, differences in tolerance were due to variations in Mn distribution and speciation within leaves. In Mn-sensitive soybean, in situ analysis of fresh leaves using x-ray fluorescence microscopy combined with x-ray absorption near edge structure showed high Mn in the veins, and manganite [Mn(III)] accumulated in necrotic lesions apparently through low Mn sequestration in vacuoles or other vesicles. In the two lupin species, most Mn accumulated in vacuoles as either soluble Mn(II) malate or citrate. In sunflower, Mn was sequestered as manganite at the base of nonglandular trichomes. Hence, tolerance to high Mn was ascribed to effective sinks for Mn in leaves, as Mn(II) within vacuoles or through oxidation of Mn(II) to Mn(III) in trichomes. These two mechanisms prevented Mn accumulation in the cytoplasm and apoplast, thereby ensuring tolerance to high Mn in the root environment. C1 [Blamey, F. Pax C.; Hernandez-Soriano, Maria C.; Kopittke, Peter M.] Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld 4072, Australia. [Cheng, Miaomiao; Tang, Caixian] La Trobe Univ, Ctr AgriBiosci, Bundoora, Vic 3086, Australia. [Paterson, David J.] Australian Synchrotron, Clayton, Vic 3168, Australia. [Lombi, Enzo; Wang, Wei Hong] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. RP Kopittke, PM (reprint author), Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld 4072, Australia. EM p.kopittke@uq.edu.au RI Kopittke, Peter/A-6026-2011; HERNANDEZ-SORIANO, MARIA/H-2401-2011; Lombi, Enzo/F-3860-2013; OI Kopittke, Peter/0000-0003-4948-1880; HERNANDEZ-SORIANO, MARIA/0000-0002-8006-9192; Lombi, Enzo/0000-0003-3384-0375; Scheckel, Kirk/0000-0001-9326-9241 FU Australian Research Council [FT100100337, FT120100277]; Linkage Project [LP100100800]; University of Queensland; Australian Synchrotron, Victoria, Australia [AS153/XFM/8467]; U.S. Department of Energy (DOE); MRCAT member institutions; DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357] FX This work was supported by the Australian Research Council (Future Fellowship nos. FT100100337 to E.L. and FT120100277 to P.M.K. and Linkage Project no. LP100100800 to C.T.) and The University of Queensland (postdoctoral fellowship to M.C.H.-S.). Parts of this research were conducted at the XFM beamline at the Australian Synchrotron, Victoria, Australia (Project AS153/XFM/8467). MRCAT operations are supported by the U.S. Department of Energy (DOE) and the MRCAT member institutions. This research used resources of the Advanced Photon Source, a U.S. DOE Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract no. DE-AC02-06CH11357. NR 44 TC 2 Z9 2 U1 4 U2 31 PU AMER SOC PLANT BIOLOGISTS PI ROCKVILLE PA 15501 MONONA DRIVE, ROCKVILLE, MD 20855 USA SN 0032-0889 EI 1532-2548 J9 PLANT PHYSIOL JI Plant Physiol. PD NOV PY 2015 VL 169 IS 3 BP 2006 EP 2020 DI 10.1104/pp.15.00726 PG 15 WC Plant Sciences SC Plant Sciences GA CZ9BX UT WOS:000367393900043 PM 26395840 ER PT J AU Lai, DY AF Lai, David Y. TI Approach to using mechanism-based structure activity relationship (SAR) analysis to assess human health hazard potential of nanomaterials SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Nanotoxicology; Toxicity of nanomaterials; Toxicity of nanoparticles; Physicochemical characteristics and nanotoxicity; Mechanism of nanotoxicity; SAR of nanotoxicity ID METAL-OXIDE NANOPARTICLES; MULTIWALLED CARBON NANOTUBES; INDUCE OXIDATIVE STRESS; IN-VITRO; PULMONARY TOXICITY; SILVER NANOPARTICLES; ULTRAFINE PARTICLES; GOLD NANOPARTICLES; PARIETAL PLEURA; SURFACE-AREA AB With the increasing use and development of engineered nanoparticles in electronics, consumer products, pesticides, food and pharmaceutical industries, there is a growing concern about potential human health hazards of these materials. A number of studies have demonstrated that nanoparticle toxicity is extremely complex, and that the biological activity of nanoparticles will depend on a variety of physicochemical properties such as particle size, shape, agglomeration state, crystal structure, chemical composition, surface area and surface properties. Nanoparticle toxicity can be attributed to nonspecific interaction with biological structures due to their physical properties (e.g., size and shape) and biopersistence, or to specific interaction with biomolecules through their surface properties (e.g., surface chemistry and reactivity) or release of toxic ions. The toxic effects of most nanomaterials have not been adequately characterized and currently, there are many issues and challenges in toxicity testing and risk assessment of nanoparticles. Based on the possible mechanisms of action and available in vitro and in vivo toxicity database, this paper proposes an approach to using mechanism-based SAR analysis to assess the relative human health hazard/risk potential of various types of nanomaterials. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Lai, David Y.] US EPA, Off Pollut Prevent & Tox, Risk Assessment Div, Washington, DC 20460 USA. RP Lai, DY (reprint author), US EPA, Off Pollut Prevent & Tox, Risk Assessment Div, 1200 Penn Ave NW, Washington, DC 20460 USA. EM dylai09@gmail.com NR 66 TC 2 Z9 2 U1 5 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 EI 1873-6351 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD NOV PY 2015 VL 85 BP 120 EP 126 DI 10.1016/j.fct.2015.06.008 PG 7 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA CZ2RC UT WOS:000366951300015 PM 26111809 ER PT J AU Mundy, WR Padilla, S Breier, JM Crofton, KM Gilbert, ME Herr, DW Jensen, KF Radio, NM Raffaele, KC Schumacher, K Shafer, TJ Cowden, J AF Mundy, William R. Padilla, Stephanie Breier, Joseph M. Crofton, Kevin M. Gilbert, Mary E. Herr, David W. Jensen, Karl F. Radio, Nicholas M. Raffaele, Kathleen C. Schumacher, Kelly Shafer, Timothy J. Cowden, John TI Expanding the test set: Chemicals with potential to disrupt mammalian brain development SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Review DE Neurotoxicity; Brain; Development; Toxicity testing; Reference chemicals ID PERINATAL HEPTACHLOR EXPOSURE; ANTIEPILEPTIC DRUG EXPOSURE; ANXIETY-RELATED BEHAVIOR; EPIDERMAL-GROWTH-FACTOR; LONG-TERM POTENTIATION; POSTNATAL MOUSE-BRAIN; ARM MAZE PERFORMANCE; DEVELOPING RAT-BRAIN; SWISS-WEBSTER MICE; PRENATAL EXPOSURE AB High-throughput test methods including molecular, cellular, and alternative species-based assays that examine critical events of normal brain development are being developed for detection of developmental neurotoxicants. As new assays are developed, a "training set" of chemicals is used to evaluate the relevance of individual assays for specific endpoints. Different training sets are necessary for each assay that would comprise a developmental neurotoxicity test battery. In contrast, evaluation of the predictive ability of a comprehensive test battery requires a set of chemicals that have been shown to alter brain development after in vivo exposure ("test set"). Because only a small number of substances have been well documented to alter human neurodevelopment, we have proposed an expanded test set that includes chemicals demonstrated to adversely affect neurodevelopment in animals. To compile a list of potential developmental neurotoxicants, a literature review of compounds that have been examined for effects on the developing nervous system was conducted. The search was limited to mammalian studies published in the peer-reviewed literature and regulatory studies submitted to the U.S. EPA The definition of developmental neurotoxicity encompassed changes in behavior, brain morphology, and neurochemistry after gestational or lactational exposure. Reports that indicated developmental neurotoxicity was observed only at doses that resulted in significant maternal toxicity or were lethal to the fetus or offspring were not considered. As a basic indication of reproducibility, we only included a chemical if data on its developmental neurotoxicity were available from more than one laboratory (defined as studies originating from laboratories with a different senior investigator). Evidence from human studies was included when available. Approximately 100 developmental neurotoxicity test set chemicals were identified, with 22% having evidence in humans. Published by Elsevier Inc. C1 [Mundy, William R.; Padilla, Stephanie; Breier, Joseph M.; Gilbert, Mary E.; Herr, David W.; Jensen, Karl F.; Radio, Nicholas M.; Shafer, Timothy J.] US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Crofton, Kevin M.; Cowden, John] US Environm Protect Agcy, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Raffaele, Kathleen C.] US Environm Protect Agcy, Off Solid Waste & Emergency Response, Washington, DC USA. [Schumacher, Kelly] US Environm Protect Agcy, Reg 7, Lenexa, KS USA. RP Mundy, WR (reprint author), US Environm Protect Agcy, Integrated Syst Toxicol Div, MD-B105-03, Res Triangle Pk, NC 27711 USA. EM mundy.william@epa.gov RI Crofton, Kevin/J-4798-2015 OI Crofton, Kevin/0000-0003-1749-9971 NR 252 TC 4 Z9 4 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 BP 25 EP 35 DI 10.1016/j.ntt.2015.10.001 PN A PG 11 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YE UT WOS:000367108300004 PM 26476195 ER PT J AU Makris, SL Vorhees, CV AF Makris, Susan L. Vorhees, Charles V. TI Assessment of learning, memory and attention in developmental neurotoxicity regulatory studies: Introduction SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Learning and memory testing; Developmental Neurotoxicity Testing; Regulatory studies; Environmental Protection Agency; Organization for Economic Cooperation and; Development AB There are a variety of chemicals, including pharmaceuticals, that alter neurobehavior following developmental exposure and guidelines for the conduct of studies to detect such effects by statute in the United States and Europe. Guidelines for Developmental Neurotoxicity Testing (DNT) studies issued by the U.S. Environmental Protection Agency (EPA) under prevailing law and European Organization for Economic Cooperation and Development (OECD) recommendations to member countries provide that such studies include a series of neurobehavioral and neuropathological assessments. Among these are assessment of cognitive function, specifically learning and memory. After reviewing 69 DNT studies submitted to the EPA, tests of learning and memory were noted to have detected the lowest observed adverse effect level (LOAELs) less frequently than behavioral tests of locomotor activity and acoustic/auditory startle, but slightly more than for the developmental Functional Observational Battery (devFOB; which is less extensive than the full FOB), but the reasons for the lower LOAEL detection rate for learning and memory assessment could not be determined. A major concern identified in the review, however, was the adequacy of the methods employed in these studies rather than on the importance of learning and memory to the proper assessment of brain function. Accordingly, a symposium was conducted to consider how the guidelines for tests of learning and memory might be improved. Four laboratories with established histories investigating the effects of chemical exposures during development on learning, memory, and attention, were invited to review the topic and offer recommendations, both theoretical and practical, on approaches to improve the assessment of these vital CNS functions. Reviewers were asked to recommend methods that are grounded in functional importance to CNS integrity, well-validated, reliable, and amenable to the context of regulatory studies as well as to basic research on the underlying processes they measure. This Introduction sets the stage for the reviews by providing the background and regulatory context for improved tests for learning and memory in DNT and other regulatory studies, such as single- or multi-generational studies where similar methods are incorporated. (C) 2015 Elsevier Inc All rights reserved. C1 [Makris, Susan L.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Vorhees, Charles V.] Univ Cincinnati, Coll Med, Cincinnati Childrens Res Fdn, Cincinnati, OH 45221 USA. RP Vorhees, CV (reprint author), Cincinnati Childrens Res Fdn, Div Neurol, 3333 Burnet Ave, Cincinnati, OH 45229 USA. EM makris.susan@epa.gov; Charles.vorhees@cchmc.org FU Environmental Protection Agency, National Center for Environmental Assessment [EP-13-H-000399] FX The Neurobehavioral Teratology Society symposium was supported by the Environmental Protection Agency, National Center for Environmental Assessment (contract number EP-13-H-000399). NR 17 TC 2 Z9 2 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 BP 62 EP 67 DI 10.1016/j.ntt.2015.05.010 PN A PG 6 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YE UT WOS:000367108300011 PM 26049062 ER PT J AU Bushnell, PJ AF Bushnell, Philip J. TI Testing for cognitive function in animals in a regulatory context SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Cognitive function; Behavioral screen; Functional observational battery; Motor activity; Acute tests; Developmental exposure ID LEAD-EXPOSURE; TRIAZOLE FUNGICIDE; MOTOR-ACTIVITY; POLYCHLORINATED-BIPHENYLS; COMMERCIAL MIXTURE; ACUTE CHLORPYRIFOS; NEONATAL-RAT; ADULT-RATS; HYPOTHYROIDISM; BATTERY AB Superior cognitive functions have allowed the human species to proliferate in a world of incredible biological diversity. Threats to these essential capacities cannot be ignored, and a strategy is needed to evaluate the hazard posed by exposure to chemical and other agents. Because people exposed to chemicals often complain about confusion and forgetfulness, it is commonly thought that cognitive functions should be sensitive indicators of adverse consequences of chemical exposure. For these reasons, complex tests of cognitive function have been developed and deployed in experimental animal laboratories for decades. However, the results of these tests are rarely used as points of departure for chemical risk assessments. Due to their high cost in time, animals, and equipment, the efficacy and utility of these tests need to be evaluated in relation to cheaper and faster whole-animal screening methods. This review examines evidence for the assertions that cognitive functions represent uniquely sensitive indicators of chemical exposure, and that animal models of these functions are necessary to detect and quantify the neurotoxicity of chemicals. Studies conducted since the early 1980s to compare these approaches to assess the neurotoxicity of chemicals are reviewed for both adult and perinatal exposures in experimental rodents. Forty-one studies of 35 chemicals were found that directly compared acute effects using complex tests (i.e., tests that require training animals) with acute effects using screening tests (i.e., tests that do not require training animals) in adult rodents. Complex tests detected effects of three substances (bitertanol, iso-amyl nitrite, and Pfiesteria toxin) that had no effect on screening tests; for an additional five chemicals (carbaryl, deltamethrin, methyl mercury, tetraethyl tin, and Isopar-C), complex tests identified effects at lower doses than did screening tests. Fewer comparable cases were found for developmental exposures: screening and complex tests were found to be equivalent for trimethyltin, n-propylthiouracil (PTU), and elemental mercury. Analysis of two studies yielded an inconclusive case for lead. Evidence for the insufficiency of screening tests was found for PCBs and inhaled ethanol, though it is not clear that the measured effects of these chemicals reflected cognitive deficits per se. Whether these benefits are worth the additional time and expense of conducting complex tests is a matter for discussion in the research and risk management communities. Published by Elsevier Inc. C1 [Bushnell, Philip J.] US EPA, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Res Triangle Pk, NC 27711 USA. RP Bushnell, PJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, MD B105-04, Res Triangle Pk, NC 27711 USA. EM Bushnell.philip@epa.gov NR 39 TC 4 Z9 4 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 BP 68 EP 77 DI 10.1016/j.ntt.2014.04.068 PN A PG 10 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YE UT WOS:000367108300012 PM 24815542 ER PT J AU Vorhees, CV Makris, SL AF Vorhees, Charles V. Makris, Susan L. TI Assessment of learning, memory, and attention in developmental neurotoxicity regulatory studies: synthesis, commentary, and recommendations SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Learning and memory; Developmental neurotoxicity; Radial arm maze; Morris water maze; Cincinnati water maze; Cognitive tests in rodents ID NEONATAL METHAMPHETAMINE EXPOSURE; MORRIS WATER MAZE; CORTICOSTERONE RELEASE; SPATIAL NAVIGATION; POSITIVE CONTROL; WORKING-MEMORY; RATS; DEFICITS; (+)-METHAMPHETAMINE; IMPAIRMENTS AB Cognitive tests of learning and memory (L&M) have been required by U.S. Environmental Protection Agency (EPA) developmental neurotoxicity test (DNT) guidelines for more than two decades. To evaluate the utility of these guidelines, the EPA reviewed 69 pesticide DNT studies. This review found that the DNT provided or could provide the point-of-departure for risk assessment by showing the Lowest Observable Adverse Effect Level (LOAEL) in 28 of these studies in relation to other reported end points. Among the behavioral tests, locomotor activity and auditory/acoustic startle provided the most LOAELs, and tests of cognitive function and the Functional Observational Battery (FOB) the fewest. Two issues arose from the review: (1) what is the relative utility of cognitive tests versus tests of unconditioned behavior, and (2) how might cognitive tests be improved? The EPA sponsored a symposium to address this. Bushnell reviewed studies in which both screening (locomotor activity, FOB, reflex ontogeny, etc.) and complex tests (those requiring training) were used within the same study; he found relatively little evidence that complex tests provided a LOAEL lower than screening tests (with exceptions). Levin reviewed reasons for including cognitive tests in regulatory studies and methods and evidence for the radial arm maze and its place in developmental neurotoxicity assessments. Driscoll and Strupp reviewed the value of serial reaction time operant methods for assessing executive function in developmental neurotoxicity studies. Vorhees and Williams reviewed the value of allocentric (spatial) and egocentric cognitive tests and presented methods for using the Morris water maze for spatial and the Cincinnati water maze for egocentric cognitive assessment. They also reviewed the possible use of water radial mazes. The relatively lower impact of cognitive tests in previous DNT studies in the face of the frequency of human complaints of chemical-induced cognitive dysfunction indicates that animal cognitive tests need improvement. The contributors to this symposium suggest that if the guidelines are updated, they be made more specific by recommending preferred tests and providing greater detail on key characteristics of such tests. Additionally, it is recommended that guidance be developed to address important issues with cognitive tests and to provide the information needed to improve the design, conduct, and interpretation of tests of higher function within a regulatory context. These steps will maximize the value of cognitive tests for use in hazard evaluation and risk assessment. (C) 2015 Elsevier Inc. All rights reserved. C1 [Vorhees, Charles V.] Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45229 USA. [Makris, Susan L.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Vorhees, CV (reprint author), Div Neurol, Cincinnati Childrens Res Fdn, 3333 Burnet Ave, Cincinnati, OH 45229 USA. EM Charles.vorhees@cchmc.org; makris.susan@epa.gov FU Environmental Protection Agency, National Center for Environmental Assessment [EP-13-H-000,399] FX The Neurobehavioral Teratology Society (since renamed the Developmental Neurotoxicology Society) symposium was supported by the Environmental Protection Agency, National Center for Environmental Assessment (contract number EP-13-H-000,399). NR 34 TC 1 Z9 1 U1 2 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 BP 109 EP 115 DI 10.1016/j.ntt.2015.10.004 PN A PG 7 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YE UT WOS:000367108300016 PM 26526903 ER PT J AU Behl, M Hsieh, JH Shafer, TJ Mundy, WR Rice, JR Boyd, WA Freedman, JH Hunter, ES Jarema, KA Padilla, S Tice, RR AF Behl, Mamta Hsieh, Jui-Hua Shafer, Timothy J. Mundy, William R. Rice, Julie R. Boyd, Windy A. Freedman, Jonathan H. Hunter, E. Sidney, III Jarema, Kimberly A. Padilla, Stephanie Tice, Raymond R. TI Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Flame retardants; neurotoxicity; developmental toxicity; embryonic stem cells; Caenorhabditis elegans; zebrafish ID NEMATODE CAENORHABDITIS-ELEGANS; MESSENGER-RNA EXPRESSION; MICROELECTRODE ARRAYS; LOCOMOTOR-ACTIVITY; BRAIN-DEVELOPMENT; THYROID-HORMONE; PHASE-OUT; EXPOSURE; ZEBRAFISH; PHOSPHATE AB Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs) are being phased out of commercial use, leading to the increased use of alternative chemicals such as the organophosphorus flame retardants (OPERs). There is, however, limited information on the potential health effects of OPFRs. Due to the structural similarity of the OPFRs to organophosphorus insecticides, there is concern regarding developmental toxicity and neurotoxicity. In response, we evaluated a set of OPERs (triphenyl phosphate [TPHP]), isopropylated phenyl phosphate [IPP], 2-ethylhexyl diphenyl phosphate [EHDP], tert-butylated phenyl diphenyl phosphate [BPDP], trimethyl phenyl phosphate [TMPP], isodecyl diphenyl phosphate [IDDP], (tris(1,3-dichloroisopropyl) phosphate [TDCIPP], and tris(2-chloroethyl)phosphate [TCEP]) in a battery of cell-based in vitro assays and alternative model organisms and compared the results to those obtained for two classical BFRs (3,3',5,5'-tetrabromobisphenol A [TBBPA] and 2,2'4,4'-brominated diphenyl ether [BDE-47]). The assays used evaluated the effects of chemicals on the differentiation of mouse embryonic stem cells, the proliferation and growth of human neural stem cells, rat neuronal growth and network activity, and development of nematode (Caenorhabditis elegans) and zebrafish (Danio rerio). All assays were performed in a concentration-response format, allowing for the determination of the point of departure (POD: the lowest concentration where a chemically-induced response exceeds background noise). The majority of OPERs (8/9) were active in multiple assays in the range of 1-10 mu M, most of which had comparable activity to the BFRs TBBPA and BDE-47. TCEP was negative in all assays. The results indicate that the replacement OPFRs, with the exception of TCEP, showed comparable activity to the two BFRs in the assays tested. Based on these results, more comprehensive studies are warranted to further characterize the potential hazard of some of these OPFR compounds. Published by Elsevier Inc. C1 [Behl, Mamta; Rice, Julie R.; Boyd, Windy A.; Tice, Raymond R.] NIEHS, Div Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Shafer, Timothy J.; Mundy, William R.; Hunter, E. Sidney, III; Jarema, Kimberly A.; Padilla, Stephanie] US EPA, Integrated Syst Toxicol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Freedman, Jonathan H.] Univ Louisville, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA. [Hsieh, Jui-Hua] Kelly Govt Solut, Res Triangle Pk, NC USA. RP Behl, M (reprint author), NIEHS, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA. EM behlmv@niehs.nih.gov OI Boyd, Windy/0000-0003-3803-3716 NR 66 TC 17 Z9 17 U1 15 U2 52 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 SI SI BP 181 EP 193 DI 10.1016/j.ntt.2015.09.003 PN B PG 13 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YF UT WOS:000367108400009 PM 26386178 ER PT J AU Jarema, KA Hunter, DL Shaffer, RM Behl, M Padilla, S AF Jarema, Kimberly A. Hunter, Deborah L. Shaffer, Rachel M. Behl, Mamta Padilla, Stephanie TI Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Zebrafish; Neurotoxicity; Flame retardants; Developmental; Acute ID INDUCED DELAYED NEUROTOXICITY; HALOGENATED BISPHENOL-A; JUVENILE RAT-BRAIN; DANIO-RERIO; LARVAL ZEBRAFISH; CHLORPYRIFOS EXPOSURE; LOCOMOTOR-ACTIVITY; PENTABDE REPLACEMENT; TRIPHENYL PHOSPHATE; HEPTACHLOR EXPOSURE AB As polybrominated diphenyl ethers are phased out, numerous compounds are emerging as potential replacement flame retardants for use in consumer and electronic products. Little is known, however, about the neurobehavioral toxicity of these replacements. This study evaluated the neurobehavioral effects of acute or developmental exposure to t-butylphenyl diphenyl phosphate (BPDP), 2-ethylhexyl diphenyl phosphate (EHDP), isodecyl diphenyl phosphate (IDDP), isopropylated phenyl phosphate (IPP), tricresyl phosphate (TMPP; also abbreviated TCP), triphenyl phosphate (TPHP; also abbreviated TPP), tetrabromobisphenol A (TBBPA), tris (2-chloroethyl) phosphate (TCEP), tris (1,3-dichloroisopropyl) phosphate (TDCIPP; also abbreviated TDCPP), tri-o-cresyl phosphate (TOCP), and 2,2-,4,4'-tetrabromodiphenyl ether (BDE-47) in zebrafish (Danio redo) larvae. Larvae (n approximate to 24 per dose per compound) were exposed to test compounds (0.4-120 mu M) at subteratogenic concentrations either developmentally or acutely, and locomotor activity was assessed at 6 days post fertilization. When given developmentally, all chemicals except BPDP, IDDP and TBBPA produced behavioral effects. When given acutely, all chemicals produced behavioral effects, with TPHP, TBBPA, EHDP, IPP, and BPDP eliciting the most effects at the most concentrations. The results indicate that these replacement flame retardants may have developmental or pharmacological effects on the vertebrate nervous system. Published by Elsevier Inc. C1 [Jarema, Kimberly A.] US EPA, Toxicol Assessment Div, NHEERL, Res Triangle Pk, NC 27711 USA. [Hunter, Deborah L.; Shaffer, Rachel M.; Padilla, Stephanie] US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA. [Shaffer, Rachel M.] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC USA. [Behl, Mamta] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. RP Padilla, S (reprint author), US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA. EM Padilla.stephanie@epa.gov FU NIEHS NIH HHS [T32 ES007126] NR 87 TC 12 Z9 12 U1 10 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 SI SI BP 194 EP 209 DI 10.1016/j.ntt.2015.08.010 PN B PG 16 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YF UT WOS:000367108400010 PM 26348672 ER PT J AU Moser, VC Phillips, PM Hedge, JM McDaniel, KL AF Moser, Virginia C. Phillips, Pamela M. Hedge, Joan M. McDaniel, Katherine L. TI Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP) SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Developmental neurotmdcity; Flame retardants; Thyrotoxicity; Tris(1,3-dichloro-2-propyl)phosphate; Tris(2-chloro-2-ethyl)phosphate ID ORGANOPHOSPHATE FLAME RETARDANTS; MESSENGER-RNA EXPRESSION; ZEBRAFISH DANIO-RERIO; MORRIS WATER MAZE; PHOSPHATE TDCPP; HOUSE-DUST; URINARY METABOLITES; PHASE-OUT; TOXICITY; TRIS(2-CHLOROETHYL)PHOSPHATE AB Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP) are organophosphorous flame retardants with widespread usage and human exposures through food, inhalation, and dust ingestion. They have been detected in human tissues including urine and breast milk. Reports of disrupted neural growth in vitro, abnormal development in larval zebrafish, and altered thyroid hormones in several species have raised concern for neurodevelopmental toxicity. This is especially the case for TDCIPP, which is more potent and has more activity in those assays than does TCEP. We evaluated the potential for developmental neurotoxicity of TDCIPP and TCEP in a mammalian model. Pregnant Long Evans rats were administered TDCIPP (15, 50, or 150 mg/kg/day) or TCEP (12, 40, 90 mg/kg/day) via oral gavage from gestational day 10 to weaning. Corn oil was the vehicle control in both studies. Body weight and righting reflex development were monitored in all pups. A subset of offspring at Culling and weaning, and dams at weaning, were sacrificed for serum and organ collection for measurement of brain, liver, and thyroid weights, serum thyroid levels, and serum and brain acetylcholinesterase activities. Brain weights were also measured in a group of adult TDCIPP-treated offspring. One male and one female from each litter were allocated for behavioral testing at several ages: standard locomotor activity (preweaning, postweaning, adults), locomotor activity including a lighting change mid-way (postweaning, adults), elevated zero maze (postweaning, adults), functional observational battery (FOB; postweaning, adults), and Morris water maze (place learning, reference and working memory; adults). Neither chemical produced changes in maternal body weight or serum thyroid hormones, but relative liver weight was increased at the high doses of both TDCIPP and TCEP. In offspring, there were no effects on viability, litter size, or birth weight. With TDCIPP, absolute liver weights were lower at weaning and weight gain was lower in the high-dose offspring until about two months of age. Thyroid hormones and brain weights were not altered and acetylcholinesterase (both brain and serum) was not inhibited by either chemical. TDCIPP-treated offspring showed slight differences in floating in the water maze, hindlimb grip strength, and altered activity habituation, whereas TCEP-treated rats showed differences in quadrant time (probe) and middle-zone preference in the water maze. Regarding these few changes, the effects were minimal, mostly not related to dose, and did not appear treatment-related or biologically significant Overall, these data do not support the potential for thyrotoxicity or developmental neurotoxicity produced by TDCIPP or TCEP. Published by Elsevier Inc. C1 [Moser, Virginia C.; Phillips, Pamela M.; McDaniel, Katherine L.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Hedge, Joan M.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Moser, VC (reprint author), US EPA, MD B105-04, Res Triangle Pk, NC 27711 USA. EM Moser.ginger@epa.gov FU Office of Research and Development, US EPA FX The authors gratefully acknowledge Drs. B. Mundy and M. Gilbert for their review of an earlier form of this manuscript. All research was funded internally by the Office of Research and Development, US EPA. NR 69 TC 6 Z9 6 U1 11 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2015 VL 52 SI SI BP 236 EP 247 DI 10.1016/j.ntt.2015.08.004 PN B PG 12 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA CZ4YF UT WOS:000367108400014 PM 26300399 ER PT J AU Humayun, MT Divan, R Stan, L Gupta, A Rosenmann, D Gundel, L Solomon, PA Paprotny, I AF Humayun, Md Tanim Divan, Ralu Stan, Liliana Gupta, Ashu Rosenmann, Daniel Gundel, Lara Solomon, Paul A. Paprotny, Igor TI ZnO functionalization of multiwalled carbon nanotubes for methane sensing at single parts per million concentration levels SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID ATOMIC LAYER DEPOSITION; VANADIUM-OXIDE; GAS-DETECTION; THIN-FILMS; SENSORS; HETEROSTRUCTURES AB This paper presents a novel atomic layer deposition (ALD) based ZnO functionalization of surface pretreated multiwalled carbon nanotubes (MWCNTs) for highly sensitive methane chemoresistive sensors. The temperature optimization of the ALD process leads to enhanced ZnO nanoparticle functionalization and improvement in their crystalline quality as shown by energy dispersive x-ray and Raman spectroscopy. The behavior of ZnO-MWCNT sensors in presence of methane concentrations down to 2 ppm level has been compared with that of pristine MWCNTs demonstrating that ZnO functionalization is an essential factor behind the highly sensitive chemoresistive nature of the ZnO-MWCNT heterostructures. The sensor is currently being tested under a range of conditions that include potentially interfering gases and changes to relative humidity. (C) 2015 American Vacuum Society. C1 [Humayun, Md Tanim; Paprotny, Igor] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. [Divan, Ralu; Stan, Liliana; Rosenmann, Daniel] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. [Gupta, Ashu] Illinois Math & Sci Acad, Aurora, IL 60506 USA. [Gundel, Lara] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Solomon, Paul A.] US EPA, Las Vegas, NV 89199 USA. RP Humayun, MT (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. EM paprotny@uic.edu FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; College of Engineering, University of Illinois, Chicago, IL FX The authors would like to thank David Gosztola, CNM, Argonne National Laboratory, for helping with the Raman spectroscopy. Use of the Center for Nanoscale Materials, an Office of Science user facility, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. College of Engineering, University of Illinois, Chicago, IL, in part funded the project. The U.S. Environmental Protection Agency, through its Office of Research and Development, collaborated in the research described here. It has been subjected to Agency review and approved for publication. NR 25 TC 3 Z9 3 U1 2 U2 32 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2015 VL 33 IS 6 AR 06FF01 DI 10.1116/1.4931694 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA CX9WE UT WOS:000366055600033 ER PT J AU Broome, RA Fann, N Cristina, TJN Fulcher, C Duc, H Morgan, GG AF Broome, Richard A. Fann, Neal Cristina, Tina J. Navin Fulcher, Charles Duc, Hiep Morgan, Geoffrey G. TI The health benefits of reducing air pollution in Sydney, Australia SO ENVIRONMENTAL RESEARCH LA English DT Article DE FM2.5; Ozone; Sydney; Australia; Health impact; Environmental benefits mapping andanalysis program - community edition; Fine particles ID LONG-TERM EXPOSURE; FINE PARTICULATE MATTER; HOSPITAL ADMISSIONS; UNITED-STATES; CARDIOVASCULAR MORTALITY; RESPIRATORY-DISEASES; LIFE EXPECTANCY; OZONE EXPOSURE; US; IMPACT AB Among industrialised countries, fine particle (PM2.5) and ozone levels in the Sydney metropolitan area of Australia are relatively low. Annual mean PM2.5 levels have historically remained below 8 mu g/m(3) while warm season (November-March) ozone levels occasionally exceed the Australian guideline value of 0.10 ppm (daily 1 h max). Yet, these levels are still below those seen in the United States and Europe. This analysis focuses on two related questions: (1) what is the public health burden associated with air pollution in Sydney; and (2) to what extent would reducing air pollution reduce the number of hospital admissions, premature deaths and number of years of life lost (YLL)? We addressed these questions by applying a damage function approach to Sydney population, health, PM2.5 and ozone data for 2007 within the BenMAP-CE software tool to estimate health impacts and economic benefits. We found that 430 premature deaths (90% CI: 310-540) and 5800 YLL (95% CI: 3900-7600) are attributable to 2007 levels of PM2.5 (about 2% of total deaths and 1.8% of YLL in 2007). We also estimate about 630 (95% CI: 410-840) respiratory and cardiovascular hospital admissions attributable to 2007 PM2.5 and ozone exposures. Reducing air pollution levels by even a small amount will yield a range of health benefits. Reducing 2007 PM2.5 exposure in Sydney by 10% would, over 10 years, result in about 650 (95% CI: 430850) fewer premature deaths, a gain of 3500 (95% CI: 2300-4600) life-years and about 700(95% CI: 450-930) fewer respiratory and cardiovascular hospital visits. These results suggest that substantial health benefits are attainable in Sydney with even modest reductions in air pollution. (C) 2015 Elsevier Inc. All rights reserved. C1 [Broome, Richard A.; Cristina, Tina J. Navin] Sydney Local Hlth Dist, Publ Hlth Observ, Sydney, NSW, Australia. [Fann, Neal; Fulcher, Charles] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Duc, Hiep] NSW Off Environm & Heritage, Sydney, NSW, Australia. [Morgan, Geoffrey G.] Univ Sydney, Univ Ctr Rural Hlth North Coast, Sydney, NSW 2006, Australia. [Morgan, Geoffrey G.] Mid North Coast Local Hlth Dist, North Coast Publ Hlth Unit, Sydney, NSW, Australia. RP Broome, RA (reprint author), POB 374, Camperdown, NSW 1450, Australia. EM richard.broome@sswahs.nsw.gov.au RI Duc , Hiep/B-5616-2016 OI Duc , Hiep/0000-0002-6658-4382 NR 43 TC 6 Z9 6 U1 10 U2 31 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2015 VL 143 BP 19 EP 25 DI 10.1016/j.envres.2015.09.007 PN A PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CX6SJ UT WOS:000365831400003 PM 26414085 ER PT J AU Lee, S Barron, MG AF Lee, Sehan Barron, Mace G. TI Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches SO TOXICOLOGICAL SCIENCES LA English DT Article DE AChE; 3D-QSAR; 3D-fingerprint; molecular docking; structure-based pharmacophore ID ACTIVE-SITE GORGE; BETA-AMYLOID AGGREGATION; ALZHEIMERS-DISEASE; AROMATIC RESIDUES; DIRECTED LIGANDS; X-RAY; TACRINE; DESIGN; BUTYRYLCHOLINESTERASE; CHOLINESTERASES AB Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. With the increasing availability of AChE crystal structures, with or without ligands bound, structure-based approaches have been successfully applied to AChE inhibitors (AChEIs). The major limitation of these approaches has been the small applicability domain due to the lack of structural diversity in the training set. In this study, we developed a 3 dimensional quantitative structure-activity relationship (3D-QSAR) for inhibitory activity of 89 reversible and irreversible AChEIs including drugs and insecticides. A 3D-fingerprint descriptor encoding protein-ligand interactions was developed using molecular docking and structure-based pharmacophore to rationalize the structural requirements responsible for the activity of these compounds. The obtained 3D-QSAR model exhibited high correlation value (R-2 = 0.93) and low mean absolute error (MAE = 0.32 log units) for the training set (n = 63). The model was predictive across a range of structures as shown by the leave-one-out cross-validated correlation coefficient (Q(2) = 0.89) and external validation results (n = 26, R-2 = 0.89, and MAE = 0.38 log units). The model revealed that the compounds with high inhibition potency had proper conformation in the active site gorge and interacted with key amino acid residues, in particular Trp84 and Phe330 at the catalytic anionic site, Trp279 at the peripheral anionic site, and Gly118, Gly119, and Ala201 at the oxyanion hole. The resulting universal 3D-QSAR model provides insight into the multiple molecular interactions determining AChEI potency that may guide future chemical design and regulation of toxic AChEIs. C1 [Lee, Sehan; Barron, Mace G.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Lee, S (reprint author), US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM lee.sehan@epa.gov NR 38 TC 4 Z9 4 U1 8 U2 28 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2015 VL 148 IS 1 BP 60 EP 70 DI 10.1093/toxsci/kfv160 PG 11 WC Toxicology SC Toxicology GA CX2SU UT WOS:000365547900007 PM 26202430 ER PT J AU Wetmore, BA Wambaugh, JF Allen, B Ferguson, SS Sochaski, MA Setzer, RW Houck, KA Strope, CL Cantwell, K Judson, RS LeCluyse, E Clewell, HJ Thomas, RS Andersen, ME AF Wetmore, Barbara A. Wambaugh, John F. Allen, Brittany Ferguson, Stephen S. Sochaski, Mark A. Setzer, R. Woodrow Houck, Keith A. Strope, Cory L. Cantwell, Katherine Judson, Richard S. LeCluyse, Edward Clewell, Harvey J. Thomas, Russell S. Andersen, Melvin E. TI Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing SO TOXICOLOGICAL SCIENCES LA English DT Article DE predictive toxicology; ToxCast; in vitro-in vivo extrapolation; dosimetry; exposure assessment ID PRIMARY HUMAN HEPATOCYTES; EPAS TOXCAST PROGRAM; ENVIRONMENTAL CHEMICALS; RISK-ASSESSMENT; HEALTHY-VOLUNTEERS; METABOLIZING ENZYME; PROTEIN BINDING; DRUG CLEARANCE; SCREENING DATA; VIVO HAZARD AB We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to oral equivalent doses (OEDs) required to achieve these levels internally. These OEDs were compared against regulatory exposure estimates, providing an activity-to-exposure ratio (AER) useful for a risk-based ranking strategy. As ToxCast efforts expand (ie, Phase II) beyond food-use pesticides toward a wider chemical domain that lacks exposure and toxicity information, prediction tools become increasingly important. In this study, in vitro hepatic clearance and plasma protein binding were measured to estimate OEDs for a subset of Phase II chemicals. OEDs were compared against high-throughput (HT) exposure predictions generated using probabilistic modeling and Bayesian approaches generated by the U.S. Environmental Protection Agency (EPA) ExpoCast program. This approach incorporated chemical-specific use and national production volume data with biomonitoring data to inform the exposure predictions. This HT exposure modeling approach provided predictions for all Phase II chemicals assessed in this study whereas estimates from regulatory sources were available for only 7% of chemicals. Of the 163 chemicals assessed in this study, 3 or 13 chemicals possessed AERs < 1 or < 100, respectively. Diverse bioactivities across a range of assays and concentrations were also noted across the wider chemical space surveyed. The availability of HT exposure estimation and bioactivity screening tools provides an opportunity to incorporate a risk-based strategy for use in testing prioritization. C1 [Wetmore, Barbara A.; Allen, Brittany; Sochaski, Mark A.; Strope, Cory L.; Cantwell, Katherine; LeCluyse, Edward; Clewell, Harvey J.; Thomas, Russell S.; Andersen, Melvin E.] Inst Chem Safety Sci, Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA. [Wambaugh, John F.; Setzer, R. Woodrow; Houck, Keith A.; Judson, Richard S.; Thomas, Russell S.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Ferguson, Stephen S.] ADME, Tox Div Primary & Stem Cell Syst Business Unit, Life Technol, Durham, NC 27703 USA. RP Wetmore, BA (reprint author), Inst Chem Safety Sci, Hamner Inst Hlth Sci, POB 12137,6 Davis Dr, Res Triangle Pk, NC 27709 USA. EM bwetmore@thehamner.org OI Wambaugh, John/0000-0002-4024-534X FU American Chemistry Council's Long-Range Research Initiative; Agilent Foundation FX Funding for the research performed at The Hamner Institutes for Health Sciences, including plasma protein binding measurements, analytical chemistry analysis, computational IVIVE modeling, and PK modeling was provided by the American Chemistry Council's Long-Range Research Initiative. An equipment grant of an Agilent 6460 triple quadrupole mass spectrometer was provided by the Agilent Foundation. NR 95 TC 16 Z9 16 U1 8 U2 25 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2015 VL 148 IS 1 BP 121 EP 136 DI 10.1093/toxsci/kfv171 PG 16 WC Toxicology SC Toxicology GA CX2SU UT WOS:000365547900012 PM 26251325 ER PT J AU Judson, RS Magpantay, FM Chickarmane, V Haskell, C Tania, N Taylor, J Xia, MH Huang, RL Rotroff, DM Filer, DL Houck, KA Martin, MT Sipes, N Richard, AM Mansouri, K Setzer, RW Knudsen, TB Crofton, KM Thomas, RS AF Judson, Richard S. Magpantay, Felicia Maria Chickarmane, Vijay Haskell, Cymra Tania, Nessy Taylor, Jean Xia, Menghang Huang, Ruili Rotroff, Daniel M. Filer, Dayne L. Houck, Keith A. Martin, Matthew T. Sipes, Nisha Richard, Ann M. Mansouri, Kamel Setzer, R. Woodrow Knudsen, Thomas B. Crofton, Kevin M. Thomas, Russell S. TI Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor SO TOXICOLOGICAL SCIENCES LA English DT Article DE estrogen receptor; EDSP; high-throughput screening; In vitro; prioritization; biological modeling ID EPAS TOXCAST PROGRAM; ENVIRONMENTAL CHEMICALS; MOLECULAR-MECHANISMS; SELECTIVE LIGANDS; BREAST-CANCER; TOXICITY; EXPOSURE; PRIORITIZATION; IDENTIFICATION; TRANSCRIPTION AB We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the in vitro assays to predict whether a chemical is an ER agonist or antagonist, or is otherwise influencing the assays through a manner dependent on the physics and chemistry of the technology platform ("assay interference"). The method is applied to a library of 1812 commercial and environmental chemicals, including 45 ER positive and negative reference chemicals. Among the reference chemicals, the network model correctly identified the agonists and antagonists with the exception of very weak compounds whose activity was outside the concentration range tested. The model agonist score also correlated with the expected potency class of the active reference chemicals. Of the 1812 chemicals evaluated, 111 (6.1%) were predicted to be strongly ER active in agonist or antagonist mode. This dataset and model were also used to begin a systematic investigation of assay interference. The most prominent cause of false-positive activity (activity in an assay that is likely not due to interaction of the chemical with ER) is cytotoxicity. The model provides the ability to prioritize a large set of important environmental chemicals with human exposure potential for additional in vivo endocrine testing. Finally, this model is generalizable to any molecular pathway for which there are multiple upstream and downstream assays available. C1 [Judson, Richard S.; Houck, Keith A.; Martin, Matthew T.; Richard, Ann M.; Setzer, R. Woodrow; Knudsen, Thomas B.; Crofton, Kevin M.; Thomas, Russell S.] US EPA, Res Triangle Pk, NC 27711 USA. [Magpantay, Felicia Maria] Univ Manitoba, Dept Math, Winnipeg, MB R3T 2N2, Canada. [Chickarmane, Vijay] CALTECH, Div Biol, Pasadena, CA 91125 USA. [Haskell, Cymra] Univ So Calif, Dept Math, Los Angeles, CA 90089 USA. [Tania, Nessy] Smith Coll, Dept Math, Northampton, MA 01063 USA. [Taylor, Jean] NYU, Courant Inst, New York, NY 10012 USA. [Xia, Menghang; Huang, Ruili] NIH, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD 20892 USA. [Rotroff, Daniel M.] N Carolina State Univ, Dept Stat, Raleigh, NC 27607 USA. [Rotroff, Daniel M.] N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27607 USA. [Filer, Dayne L.; Mansouri, Kamel] US EPA, ORISE, Res Triangle Pk, NC 27711 USA. [Sipes, Nisha] NIH, Natl Toxicol Program, Res Triangle Pk, NC 27711 USA. RP Judson, RS (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM judson.richard@epa.gov RI Crofton, Kevin/J-4798-2015; OI Crofton, Kevin/0000-0003-1749-9971; Mansouri, Kamel/0000-0002-6426-8036 FU American Institute of Mathematics; National Science Foundation; U.S. EPA FX The authors gratefully acknowledge the American Institute of Mathematics and National Science Foundation for support of this research through the "Modeling Problems Related to Our Environment" workshop held January 14-18, 2013 in Palo Alto, California. All other funding was provided by the U.S. EPA. NR 47 TC 24 Z9 24 U1 8 U2 24 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2015 VL 148 IS 1 BP 137 EP 154 DI 10.1093/toxsci/kfv168 PG 18 WC Toxicology SC Toxicology GA CX2SU UT WOS:000365547900013 PM 26272952 ER PT J AU D'Anglada, LV AF D'Anglada, Lesley V. TI Editorial on the Special Issue "Harmful Algal Blooms (HABs) and Public Health: Progress and Current Challenges" SO TOXINS LA English DT Editorial Material ID HYDROGEN-PEROXIDE; CYANOBACTERIA; SYSTEMS; MICROCYSTINS; ILLNESSES; DYNAMICS; DEATHS C1 [D'Anglada, Lesley V.] US EPA, Off Sci & Technol, Off Water, Washington, DC 20460 USA. RP D'Anglada, LV (reprint author), US EPA, Off Sci & Technol, Off Water, 1200 Penn Ave, Washington, DC 20460 USA. EM Danglada.lesley@Epa.gov NR 14 TC 2 Z9 2 U1 8 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD NOV PY 2015 VL 7 IS 11 BP 4437 EP 4441 DI 10.3390/toxins7114437 PG 5 WC Toxicology SC Toxicology GA CX4DD UT WOS:000365647700004 PM 26837093 ER PT J AU Ghio, AJ Soukup, JM Dailey, LA Tong, HY Kesic, MJ Budinger, GRS Mutlu, GM AF Ghio, Andrew J. Soukup, Joleen M. Dailey, Lisa A. Tong, Haiyan Kesic, Matthew J. Budinger, G. R. Scott Mutlu, Goekhan M. TI Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID HUMIC-LIKE SUBSTANCES; OXIDATIVE STRESS; CIGARETTE-SMOKE; EPITHELIAL-CELLS; DIESEL EXHAUST; PARTICULATE MATTER; RADICAL GENERATION; SIGNALING PATHWAY; GENE-EXPRESSION; HUMAN LUNG AB The biological effect of an inorganic particle (i.e., silica) can be associated with a disruption in cell iron homeostasis. Organic compounds included in particles originating from combustion processes can also complex sources of host cell iron to disrupt metal homeostasis. We tested the postulate that (1) wood smoke particle (WSP) sequesters host cell iron resulting in a disruption of metal homeostasis, (2) this loss of essential metal results in both an oxidative stress and biological effect in respiratory epithelial cells, and (3) humic-like substances (HULIS), a component of WSP, have a capacity to appropriate cell iron and initiate a biological effect. BEAS-2B cells exposed to WSP resulted in diminished concentrations of mitochondrial Fe-57, whereas preincubation with ferric ammonium citrate (FAC) prevented significant mitochondrial iron loss after such exposure. Cellular oxidant generation was increased after WSP exposure, but this signal was diminished by coincubation with FAC. Similarly, exposure of BEAS-2B cells to 100 mu g/mL WSP activated mitogen-activated protein (MAP) kinases, elevated NF-E2-related factor 2/antioxidant responsive element (Nrf2 ARE) expression, and provoked interleukin (IL)-6 and IL-8 release, but all these changes were diminished by coincubation with FAC. The biological response to WSP was reproduced by exposure to 100 mu g/mL humic acid, a polyphenol comparable to HULIS included in the WSP that complexes iron. We conclude that (1) the biological response following exposure to WSP is associated with sequestration of cell iron by the particle, (2) increasing available iron in the cell diminished the biological effects after particle exposure, and (3) HULIS included in WSP can sequester the metal initiating the cell response. C1 [Ghio, Andrew J.; Soukup, Joleen M.; Dailey, Lisa A.; Tong, Haiyan] US EPA, Chapel Hill, NC 27599 USA. [Kesic, Matthew J.] Methodist Univ, Phys Assistant Program, Fayetteville, NC 28311 USA. [Budinger, G. R. Scott] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Mutlu, Goekhan M.] Sect Pulm & Crit Care, Chicago, IL 60637 USA. [Mutlu, Goekhan M.] Lung Injury Ctr, Dept Med, Chicago, IL 60637 USA. RP Ghio, AJ (reprint author), Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM ghio.andy@epa.gov FU US Environmental Protection Agency FX Support was provided by the US Environmental Protection Agency. NR 47 TC 3 Z9 3 U1 3 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD NOV PY 2015 VL 28 IS 11 BP 2104 EP 2111 DI 10.1021/acs.chemrestox.5b00270 PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA CW4RW UT WOS:000364980800006 PM 26462088 ER PT J AU Aydin, C Jarema, KA Phillips, PM Gordon, CJ AF Aydin, C. Jarema, K. A. Phillips, P. M. Gordon, C. J. TI Caloric restriction in lean and obese strains of laboratory rat: effects on body composition, metabolism, growth and overall health SO EXPERIMENTAL PHYSIOLOGY LA English DT Article ID DIETARY RESTRICTION; ENERGY-EXPENDITURE; RHESUS-MONKEYS; LONGEVITY; ADULT; MICE; TEMPERATURE; WEIGHT; LIFE; MASS AB New Findings What is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction? What is the main finding and its importance? Obese rats show marked benefits compared with lean animals. Reduced body fat is associated with improved longevity with caloric restriction (CR) in rodents. Little is known regarding effects of CR in genetically lean versus obese strains. Long-Evans (LE) and Brown Norway (BN) rats make an ideal comparison for a CR study because the percentage body fat of young adult LE rats is double that of BN rats. Male LE and BN rats were either fed ad libitum (AL) or were calorically restricted to 80 or 90% of their AL weight. The percentages of fat, lean and fluid mass were measured non-invasively at 2- to 4-week intervals. Metabolic rate and respiratory quotient were measured after 3, 6, 9 and 12months of CR. Overall health was scored monthly. The percentage of fat of the LE strain decreased with CR, whereas the percentage of fat of the BN strain remained above the AL group for several months. The percentage of lean mass increased above the AL for both strains subjected to CR. The percentage of fluid was unaffected by CR. The average metabolic rate over 22h of the BN rats subjected to CR was reduced, whereas that of LE rats was increased slightly above the AL group. The respiratory quotient of BN rats was decreased with CR. Overall health of the CR LE group was significantly improved compared with that of the AL group, whereas health of the CR BN rats was impaired compared with the AL group. Overall, the lean BN and obese LE strains differ markedly in fat utilization and metabolic response to prolonged CR. There appears to be little benefit of CR in the lean strain. C1 [Jarema, K. A.; Phillips, P. M.; Gordon, C. J.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Aydin, C.] Uludag Univ, Dept Physiol, Fac Vet Med, Bursa, Turkey. RP Gordon, CJ (reprint author), 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov NR 25 TC 1 Z9 1 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0958-0670 EI 1469-445X J9 EXP PHYSIOL JI Exp. Physiol. PD NOV 1 PY 2015 VL 100 IS 11 BP 1280 EP 1297 DI 10.1113/EP085469 PG 18 WC Physiology SC Physiology GA CW6OQ UT WOS:000365117400009 PM 26283239 ER PT J AU Ahmed, F Gulliver, JS Nieber, JL AF Ahmed, Farzana Gulliver, John S. Nieber, J. L. TI Field infiltration measurements in grassed roadside drainage ditches: Spatial and temporal variability SO JOURNAL OF HYDROLOGY LA English DT Article DE Field-saturated hydraulic conductivity; Soil moisture content; Infiltrometer; Soil texture; Stormwater control measure; Stormwater best management practice ID HIGHWAY RUNOFF; STORM-WATER; BIORETENTION AMENDMENT; URBAN RUNOFF; PERFORMANCE; REMOVAL; SOILS; MANAGEMENT; POLLUTION; SYSTEMS AB Roadside drainage ditches (grassed swales) are an attractive stormwater control measure (SCM) since they can reduce runoff volume by infiltrating water into the soil, filter sediments and associated pollutants out of the water, and settle solids onto the soil surface. In this study a total of 722 infiltration measurements were collected in five swales located in Twin-Cities, MN and one swale located in Madison, WI to characterize the field-saturated hydraulic conductivity(K-fs) derived from the infiltration measurements of these swales. Measurements were taken with a falling head device, the Modified Philip Dunne (MPD) infiltrometer, which allows the collection of simultaneous infiltration measurements at multiple locations with several infiltrometers. Field-saturated hydraulic conductivity was higher than expected for different soil texture classes. We hypothesize that this is due to plant roots creating macro-pores that break up the soil for infiltration. Statistical analysis was performed on the K-fs values to analyze the effect of initial soil moisture content, season, soil texture class and distance in downstream direction on the geometric mean K-fs value of a swale. Because of the high spatial variation of K-fs in the same swale no effect of initial soil moisture content, season and soil texture class was observed on the geometric mean K-fs value. But the distance in downstream direction may have positive or negative effect on the K-fs value. An uncertainty analysis on the K-fs value indicated that approximately twenty infiltration measurements is the minimum number to obtain a representative geometric mean K-fs value of a swale that is less than 350 m long within an acceptable level of uncertainty. (C) 2015 Published by Elsevier B.V. C1 [Ahmed, Farzana; Gulliver, John S.] Univ Minnesota, Dept Civil Environm & Geoengn, Minneapolis, MN 55414 USA. [Nieber, J. L.] Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA. RP Ahmed, F (reprint author), US EPA, 2890 Woodbridge Ave, Edison, NJ 08837 USA. EM ahmed262@umn.edu OI Ahmed, Farzana/0000-0002-4966-1649 FU Minnesota Department of Transportation (MnDOT); Minnesota Local Road Research board (LRRB); USDA National Institute of Food and Agriculture, Hatch/Multistate projects [MIN-12-023, MIN-12-059] FX We would like to acknowledge Minnesota Department of Transportation (MnDOT) and Minnesota Local Road Research board (LRRB) for funding the project and the USGS, Madison office for assisting in setting up measurements in the WI-Hwy 51, Madison swale. Anne Haws, Bradley. Weiss, Anthony Vecchi and Ugonna Ojiaku helped with field infiltration measurement and soil texture analysis. J.L. Nieber's effort on this project was partially supported by the USDA National Institute of Food and Agriculture, Hatch/Multistate projects MIN-12-023 and MIN-12-059. NR 49 TC 3 Z9 3 U1 11 U2 36 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD NOV PY 2015 VL 530 BP 604 EP 611 DI 10.1016/j.jhydrol.2015.10.012 PG 8 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CW5QD UT WOS:000365050600049 ER PT J AU Gracz, MB Moffett, MF Siegel, DI Glaser, PH AF Gracz, Michael B. Moffett, Mary F. Siegel, Donald I. Glaser, Paul H. TI Analyzing peatland discharge to streams in an Alaskan watershed: An integration of end-member mixing analysis and a water balance approach SO JOURNAL OF HYDROLOGY LA English DT Article DE Peatlands; Stream flow; EMMA; Evapotranspiration ID TABLE FLUCTUATIONS; RUNOFF GENERATION; CHEMISTRY; CATCHMENT; GROUNDWATER; WETLANDS; MIXTURE; MODELS; SHIELD; RIVER AB Peatlands are the dominant landscape element in many northern watersheds where they can have an important influence on the hydrology of streams. However, the capacity of peatlands to moderate stream flow during critical dry periods remains uncertain partly due to the difficulty of estimating discharge from extensive peat deposits. We therefore used two different approaches to quantify diffuse pore water contributions from peatlands to a creek within a small watershed in Southcentral Alaska. A sensitivity analysis of a water budget for a representative peatland within this watershed showed that a substantial surplus of pore water may remain available for subsequent discharge during a dry period after accounting for water losses to evapotranspiration. These findings were supported by end member mixing analysis (EMMA), which indicated that 55% of the stream flow during a dry period originated from the near-surface layers of peatlands within the watershed. Contributions from peatlands to stream flow in northern coastal regions may therefore provide an important buffer against the potentially harmful effects of changing climatic conditions on commercially important fish species. (C) 2015 Published by Elsevier B.V. C1 [Gracz, Michael B.] Univ Minnesota, Conservat Biol Program, St Paul, MN 55108 USA. [Gracz, Michael B.; Glaser, Paul H.] Univ Minnesota, Dept Earth Sci, Minneapolis, MN 55455 USA. [Moffett, Mary F.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Siegel, Donald I.] Syracuse Univ, Dept Earth Sci, Syracuse, NY 13244 USA. RP Glaser, PH (reprint author), Univ Minnesota, Dept Earth Sci, 310 Pillsbury Dr, Minneapolis, MN 55455 USA. EM gracz016@umn.edu; moffett.mary@epa.gov; dsiegel@syr.edu; glase001@umn.edu FU U.S. Environmental Protection Agency (EPA) [8348260]; Kenai Watershed Forum; Conservation Biology Program of the University of Minnesota; U.S. National Science Foundation [0628647] FX Funding was provided by the U.S. Environmental Protection Agency (EPA grant 8348260) through a cooperative agreement with the Kenai Watershed Forum, and also by the Conservation Biology Program of the University of Minnesota (summer fellowship to M. Gracz), and the U.S. National Science Foundation (Award-0628647 to P. Glaser). The views, trade names, and commercial products mentioned above do not constitute endorsement or recommendation for use by the EPA. NR 74 TC 2 Z9 2 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD NOV PY 2015 VL 530 BP 667 EP 676 DI 10.1016/j.jhydrol.2015.09.072 PG 10 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CW5QD UT WOS:000365050600055 ER PT J AU Mapp, L Klonicki, P Takundwa, P Hill, VR Schneeberger, C Knee, J Raynor, M Hwang, NN Chambers, Y Miller, K Pope, M AF Mapp, Latisha Klonicki, Patricia Takundwa, Prisca Hill, Vincent R. Schneeberger, Chandra Knee, Jackie Raynor, Malik Hwang, Nina Chambers, Yildiz Miller, Kenneth Pope, Misty TI Use of Enterococcus faecalis and Bacillus atrophaeus as surrogates to establish and maintain laboratory proficiency for concentration of water samples using ultrafiltration SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Drinking water; Ultrafiltration; Water Laboratory Alliance; Quality control (QC) criteria; Surrogate; Enterococcus faecalis; Bacillus atrophaeus ID SIMULTANEOUS RECOVERY; MICROBES AB The U.S. Environmental Protection Agency's (EPA) Water Laboratory Alliance (WLA) currently uses ultrafiltration (UF) for concentration of biosafety level 3 (BSL-3) agents from large volumes (up to 100-L) of drinking water prior to analysis. Most UF procedures require comprehensive training and practice to achieve and maintain proficiency. As a result, there was a critical need to develop quality control (QC) criteria. Because select agents are difficult to work with and pose a significant safety hazard, QC criteria were developed using surrogates, including Enterococcus faecalis and Bacillus atrophaeus. This article presents the results from the QC criteria development study and results from a subsequent demonstration exercise in which E. faecalis was used to evaluate proficiency using UF to concentrate large volume drinking water samples. Based on preliminary testing EPA Method 1600 and Standard Methods 9218, for E. faecalis and B. atrophaeus respectively, were selected for use during the QC criteria development study. The QC criteria established for Method 1600 were used to assess laboratory performance during the demonstration exercise. Based on the results of the QC criteria study E. faecalis and B. atrophaeus can be used effectively to demonstrate and maintain proficiency using ultrafiltration. Published by Elsevier B.V. C1 [Mapp, Latisha; Takundwa, Prisca; Raynor, Malik; Hwang, Nina] US EPA, Off Water, Washington, DC 20460 USA. [Klonicki, Patricia] CSC, Sci & Engn, Cincinnati, OH 45202 USA. [Hill, Vincent R.; Schneeberger, Chandra; Knee, Jackie] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. [Chambers, Yildiz; Miller, Kenneth; Pope, Misty] CSC, Sci & Engn, Alexandria, VA 22310 USA. [Schneeberger, Chandra] IHRC Inc, Atlanta, GA 30346 USA. RP Mapp, L (reprint author), US EPA, Off Water, 1200 Penn Ave NW, Washington, DC 20460 USA. EM Mapp.Latisha@epamail.epa.gov OI Raynor, Malik/0000-0002-2324-1662 FU EPA's Office of Ground Water and Drinking Water, Water Security Division [DW-75-922304801]; CDC Office of Public Health Preparedness and Response; Office of Environmental Microbiology; [DW-75-9223044801] FX This work was supported by the EPA's Office of Ground Water and Drinking Water, Water Security Division under Interagency Agreement DW-75-922304801. We gratefully acknowledge the contributions of Erin Silvestri (EPA NHSRC) in facilitating this partnership, as well as her contributions to our planning workgroup and review of this manuscript. Additional support was provided by CDC Office of Public Health Preparedness and Response and Office of Environmental Microbiology. The findings and conclusions in this report are those of the authors and should not be construed to represent any agency determination or policy. Use of trade names and commercial sources is for identification only and does not imply endorsement by CDC or EPA. This work was completed under Interagency Agreement DW-75-9223044801. NR 11 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD NOV PY 2015 VL 118 BP 133 EP 142 DI 10.1016/j.mimet.2015.08.013 PG 10 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA CW3KX UT WOS:000364892300022 PM 26306940 ER PT J AU Calfee, MW Wendling, M AF Calfee, M. W. Wendling, M. TI Inactivation of Burkholderia pseudomallei on environmental surfaces using spray-applied, common liquid disinfectants SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE biological agent; Burkholderia pseudomallei; decontamination; disinfection; inactivation ID PSEUDOMONAS-PSEUDOMALLEI; MELIOIDOSIS; PERSISTENCE; SURVIVAL; SOIL AB Five commercially available liquid antimicrobials were evaluated for their ability to decontaminate common environmental surface materials, contaminated with Burkholderia pseudomallei, using a spray-based disinfectant delivery procedure. Tests were conducted at both an ambient temperature (c. 20 degrees C) and a lower temperature (c. 12 degrees C) condition. Nonporous materials (glass and aluminium) were more easily decontaminated than porous materials (wood, concrete and carpet). Citric acid (1%) demonstrated poor efficacy in all test conditions. Bleach (pH-adjusted), ethanol (70%), quaternary ammonium and PineSol (R), demonstrated high (>6 log(10) reduction) efficacies on glass and aluminium at both temperatures, but achieved varying results for wood, carpet and concrete. Temperature had minimal effect on decontamination efficacy during these tests. C1 [Calfee, M. W.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Wendling, M.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Calfee, MW (reprint author), US EPA, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM calfee.worth@epa.gov OI Calfee, Michael/0000-0001-6544-329X FU U.S. Environmental Protection Agency through Office of Research and development [EP-C-10-001]; Battelle Memorial Institute FX The U.S. Environmental Protection Agency, through its Office of Research and development, funded and directed the research described herein under EP-C-10-001 with Battelle Memorial Institute. It has been subjected to the Agency's review and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the Agency. Mention of trade names, products, or services does not convey official EPA approval, endorsement, or recommendation. NR 13 TC 1 Z9 1 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0266-8254 EI 1472-765X J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD NOV PY 2015 VL 61 IS 5 BP 418 EP 422 DI 10.1111/lam.12487 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CX0JZ UT WOS:000365384000002 PM 26331308 ER PT J AU Ramananarivo, HR Maati, H Amadine, O Abdelouandi, K Barakat, A Ihiawakrim, D Ersen, O Varma, RS Solhy, A AF Ramananarivo, H. R. Maati, H. Amadine, O. Abdelouandi, K. Barakat, A. Ihiawakrim, D. Ersen, O. Varma, Rajender S. Solhy, A. TI Ecofriendly Synthesis of Ceria Foam via Carboxymethylcellulose Gelation: Application for the Epoxidation of Chalcone SO ACS Sustainable Chemistry & Engineering LA English DT Article DE Ceria foams; Biopolymer; Gelation; Xerogel; Epoxidation; Chalcone ID OXIDE FUEL-CELLS; 3-WAY CATALYSIS; LOW-TEMPERATURE; NANOPARTICLES; CEO2; OXIDATION; ALKENES; CO; TEMPLATE; EPOXIDES AB A simple and innovative process is described for the ecofriendly preparation of ceria foams via carboxymethylcellulose gelation by Ce4+ cations; heat treatment of the ensuing xerogels produces ceria foams. The influence of the concentration of cerium and of the calcination temperature of the xerogels is studied. Several characterization methods have been used and the obtained results demonstrate that this technique allows the controlled growth of ceria foams. The foamy structure apparently is responsible for UV absorption, and the ceria foam is basic enough to promote the epoxidation of chalcone; comparison of the catalytic activity of the ceria foam versus ceria prepared via a coprecipitation method shows that the ceria foam is most active as it promotes epoxidation of electron-deficient alkenes with dilute aqueous hydrogen peroxide. C1 [Ramananarivo, H. R.; Solhy, A.] Univ Mohammed VI Polytech, Ctr Adv Mat, Ben Guerir 43150, Morocco. [Maati, H.; Amadine, O.] Univ Hassan 2, FST, Casablanca 20650, Morocco. [Abdelouandi, K.] UATRS CNRST, Angle Allal Fassi FAR, Rabat 10000, Morocco. [Barakat, A.] INRA, UMR 1208, IATE, F-34060 Montpellier 1, France. [Ihiawakrim, D.; Ersen, O.] CNRS, UdS UMR 7504, IPCMS Grp Surfaces & Interfaces, F-67034 Strasbourg, France. [Varma, Rajender S.] US Environm Protect Agcy, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. RP Solhy, A (reprint author), Univ Mohammed VI Polytech, Ctr Adv Mat, Lot 660 Hay Moulay Rachid, Ben Guerir 43150, Morocco. EM Abderrahim.Solhy@um6p.ma RI Ersen, Ovidiu/I-1983-2016 FU Office Cherifien des Phosphates in the Moroccan Kingdom (OCP Group); OCP Foundation FX The financial assistance of the Office Cherifien des Phosphates in the Moroccan Kingdom (OCP Group) towards this research is hereby acknowledged. This work was also supported by a grant from the OCP Foundation. The corresponding author (SA) also extend his warmest thanks to Mr. Mohamed El Kadiri, Managing Director & General Secretary of OCP Group, who gave him the opportunity to integrate the great project: UM6P. NR 57 TC 0 Z9 0 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD NOV PY 2015 VL 3 IS 11 BP 2786 EP 2795 DI 10.1021/acssuschemeng.5b00662 PG 10 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA CV6CO UT WOS:000364358500021 ER PT J AU Gallagher, J Baldauf, R Fuller, CH Kumar, P Gill, LW McNabola, A AF Gallagher, John Baldauf, Richard Fuller, Christina H. Kumar, Prashant Gill, Laurence W. McNabola, Aonghus TI Passive methods for improving air quality in the built environment: A review of porous and solid barriers SO ATMOSPHERIC ENVIRONMENT LA English DT Review DE Passive methods; Pollutant dispersion; Barriers; Air quality; Urban planning; Policy ID URBAN STREET CANYONS; PARTICLE-SIZE DISTRIBUTIONS; PEDESTRIAN EXPOSURE; POLLUTANT DISPERSION; ULTRAFINE PARTICLES; ROADSIDE VEGETATION; PARTICULATE MATTER; WIND CONDITIONS; NOISE BARRIERS; IMPACT AB Protecting the health of growing urban populations from air pollution remains a challenge for planners and requires detailed understanding of air flow and pollutant transport in the built environment. In recent years, the work undertaken on passive methods of reducing air pollution has been examined to address the question: "how can the built environment work to alter natural dispersion patterns to improve air quality for nearby populations?" This review brings together a collective of methods that have demonstrated an ability to influence air flow patterns to reduce personal exposure in the built environment. A number of passive methods exists but, in the context of this paper, are split into two distinct categories: porous and solid barriers. These methods include trees and vegetation (porous) as well as noise barriers, low boundary walls and parked cars (solid); all of which have gained different levels of research momentum over the past decade. Experimental and modelling studies have provided an understanding of the potential for these barriers to improve air quality under varying urban geometrical and meteorological conditions. However, differences in results between these studies and real-world measurements demonstrate the challenges and complexities of simulating pollutant transport in urban areas. These methods provide additional benefits to improving air quality through altering dispersion patterns; avenue trees and vegetation are aesthetically pleasing and provides cooling and shade from direct sunlight. Additionally, real-world case studies are considered an important direction for further verification of these methods in the built environment. Developing design guidelines is an important next stage in promoting passive methods for reducing air pollution and ensuring their integration into future urban planning strategies. In addition, developing channels of communication with urban planners will enhance the development and uptake of design guidelines to improve air quality in the built environment. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Gallagher, John] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor, Gwynedd, Wales. [Baldauf, Richard] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Fuller, Christina H.] Georgia State Univ, Sch Publ Hlth, Atlanta, GA 30302 USA. [Kumar, Prashant] Univ Surrey, Dept Civil & Environm Engn, Fac Engn & Phys Sci FEPS, Guildford GU2 7XH, Surrey, England. [Kumar, Prashant] Univ Surrey, FEPS, Environm Flow Res Ctr, Guildford GU2 7XH, Surrey, England. [Gill, Laurence W.; McNabola, Aonghus] Trinity Coll Dublin, Dept Civil Struct & Environm Engn, Dublin, Ireland. RP Gallagher, J (reprint author), Bangor Univ, Sch Environm Nat Resources & Geog, Bangor, Gwynedd, Wales. EM j.gallagher@bangor.ac.uk RI Gill, Laurence/D-2592-2014; OI Gill, Laurence/0000-0002-1599-1105; McNabola, Aonghus/0000-0002-8715-1180; Gallagher, John/0000-0002-0848-6151 NR 58 TC 6 Z9 6 U1 14 U2 55 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD NOV PY 2015 VL 120 BP 61 EP 70 DI 10.1016/j.atmosenv.2015.08.075 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CV4SB UT WOS:000364255700006 ER PT J AU Dewan, N Majestic, BJ Ketterer, ME Miller-Schulze, JP Shafer, MM Schauer, JJ Solomon, PA Artamonova, M Chen, BB Imashev, SA Carmichael, GR AF Dewan, Nitika Majestic, Brian J. Ketterer, Michael E. Miller-Schulze, Justin P. Shafer, Martin M. Schauer, James J. Solomon, Paul A. Artamonova, Maria Chen, Boris B. Imashev, Sanjar A. Carmichael, Greg R. TI Stable isotopes of lead and strontium as tracers of sources of airborne particulate matter in Kyrgyzstan SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Air pollution; Soils; PM10; Sediments; Dust Long-range transport; Strontium (Sr) isotopes; Lead (Pb) isotopes; Aral Sea; Central Asia ID LONG-RANGE TRANSPORT; ARAL SEA; DUST AEROSOLS; UNITED-STATES; SAHARAN DUST; CENTRAL-ASIA; EAST-ASIA; DEPOSITION; CHINA; URBAN AB Central Asia is dominated by an arid climate and desert-like conditions, leading to the potential for long-range transport of desert dust within and out of the region. Of particular interest is the Aral Sea, which has receded in size largely due to water diversion. As a result, newly exposed sediments are resuspended by wind and thus, may be a potential new source of particulate matter within the region. Here, strontium and lead stable isotope ratios are employed along with detailed elemental composition, to explore the contribution of long-range transport of Aral Sea sediments, as well as other potential sources of dust, within Central Asia. Ambient Mho samples were collected during dust and non-dust events from mid-2008 to mid-2009 at two sites in Kyrgyzstan located 1200 and 1500 km ESE of the Aral Sea. Aral Sea sediments and local Kyrgyzstan soils were resuspended and sized to PM10. The Aral Sea sediments have an average Sr-87/Sr-86 ratio of 0.70992. In contrast, the Sr isotope ratio in local soils exhibits an average ratio of 0.71579. Ambient PMio collected in Kyrgyzstan has an average Sr-87/Sr-86 ratio of 0.71177, falling between the values of these two potential sources and indicating a complex mixture of contributing sources. At both sites, airborne Sr isotope ratios measured during dust events were similar, suggesting that Aral Sea sediments only minimally affect air quality in Kyrgyzstan. Elemental analysis and Pb isotope ratios supported this finding. While the Pb isotopes and elemental data both indicate an anthropogenic source, long-range dust transport from other deserts inside and outside the region cannot be ruled out as sources of PM10 in Central Asia. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Dewan, Nitika; Majestic, Brian J.] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA. [Ketterer, Michael E.] Metropolitan State Univ Denver, Dept Chem, Denver, CO 80204 USA. [Miller-Schulze, Justin P.] Calif State Univ Sacramento, Dept Chem, Sacramento, CA 95819 USA. [Shafer, Martin M.; Schauer, James J.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53718 USA. [Shafer, Martin M.; Schauer, James J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA. [Solomon, Paul A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA. [Artamonova, Maria] Inst Atmospher Phys, Moscow 109017, Russia. [Chen, Boris B.; Imashev, Sanjar A.] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan. [Carmichael, Greg R.] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA. RP Majestic, BJ (reprint author), Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA. EM brian.majestic@du.edu RI Imashev, Sanjar/I-7667-2016 OI Imashev, Sanjar/0000-0003-3293-3764 FU Association of Public Health Laboratories (APHL) through their Environmental Health Fellows program; US Environmental Protection Agency, through its Office of Research and Development [EP-D-06-001, 3715]; PROF Grant at the University of Denver FX The authors thank Dr. Gwyneth Gordon and Dr. Rasmus Andreason for their help and guidance in Sr ratios measurements. The authors gratefully acknowledge the NOAA Air Resources Laboratory (ARL) for the provision of the HYSPLIT transport and dispersion model and/or READY website (http://www.ready.noaa.gov) used in this publication. We acknowledge the Association of Public Health Laboratories (APHL) for funding through their Environmental Health Fellows program. The US Environmental Protection Agency, through its Office of Research and Development, funded and collaborated in the research described here under Contract EP-D-06-001 to the University of Wisconsin-Madison as a component of the International Science & Technology Center (ISTC) project # 3715 (Transcontinental Transport of Air Pollution from Central Asia to the US). It has been subjected to the Agency review and approved for publication. The isotope portion of this study was funded through a PROF Grant at the University of Denver. NR 51 TC 4 Z9 4 U1 7 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD NOV PY 2015 VL 120 BP 438 EP 446 DI 10.1016/j.atmosenv.2015.09.017 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CV4SB UT WOS:000364255700045 ER PT J AU Kustka, AB Kohut, JT White, AE Lam, PJ Milligan, AJ Dinniman, MS Mack, S Hunter, E Hiscock, MR Smith, WO Measures, CI AF Kustka, Adam B. Kohut, Josh T. White, Angelicque E. Lam, Phoebe J. Milligan, Allen J. Dinniman, Michael S. Mack, Stefanie Hunter, Elias Hiscock, Michael R. Smith, Walker O., Jr. Measures, Chris I. TI The roles of MCDW and deep water iron supply in sustaining a recurrent phytoplankton bloom on central Pennell Bank (Ross Sea) SO DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS LA English DT Article DE Phytoplankton; Ross Sea; Iron demand; Upwelling; Regional ocean modeling system ID FLOW-INJECTION-ANALYSIS; ANTARCTIC SHELF WATERS; RANDOM-WALK MODELS; SOUTHERN-OCEAN; PRIMARY PRODUCTIVITY; COMMUNITY STRUCTURE; CONTINENTAL-SHELF; CHLOROPHYLL-A; GROWTH-RATES; ICE AB During January-February 2011 standing stocks of phytoplankton (chl a) in the Pennell Bank region of the Ross Sea were variable over 10-100 km spatial scales. One area of elevated chl a on central Pennell Bank (CPB) appeared to be a recurrent mid-summer feature. The western flank (WF) of Pennell Bank had pronounced signatures of Modified Circumpolar Deep Water (MCDW). We evaluated the spatial extent of Fe limitation and net primary production and tested whether MCDW may provide elevated amounts of Fe to the CPB region, through a combination of in situ measurements, shipboard incubations and a horizontally resolved physical model. Regional fluxes of dissolved Fe from deep to surface waters were compared to calculated Fe demands. Low in situ variable to maximum fluorescence (F-v/F-m; 0.24-0.37) and surface water dissolved Fe concentrations (similar to 0.12-0.21 nM) were suggestive of widespread limitation, corroborated by the consistent responses (F-v/F-m, growth, and nutrient removal ratios) of incubation treatments to Fe addition. MCDW from the WF region had lower dissolved Fe concentrations than that measured in CDW (Circumpolar Deep Water), which suggests on-shelf modification with Fe deplete surface waters and is consistent with the lack of stimulation due to incubation amendments with filtered MCDW. Model results and empirical data suggest MCDW from the WF region is further modified and mixed en route to the CPB region, leading to both the erosion of the canonical MCDW signature and an elevated dissolved Fe inventory of CPB region deep water. This suggests the addition of Fe possibly via diagenesis, as suggested by Marsay et al. (2014). Calculated deep water supply rates to the surface waters of CPB were similar to 0.18-0.43 m d(-1), while calculated rates at the WF or northern Pennell Bank (NPB) regions were negative. The CPB populations exhibited similar to 4.5-fold higher net production rates compared to those in the WF and NPB regions and required 520-3200 nmol Fe m(-2) d(-1). The modeled vertical supply rates seem to provide similar to 2-15% of the estimated Fe requirement. Since this flux is based on subsurface dissolved Fe inventories, it does not account for any bioavailable Fe from deep water particulate sources or for Fe recycling in the upper water column. These data suggest the recurrent productivity hotspots at CPB are not fueled by Fe-rich MCDW but are partially supported by the delivery of Fe through vertical exchange processes. (C) 2015 Published by Elsevier Ltd. C1 [Kustka, Adam B.] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA. [Kohut, Josh T.; Hunter, Elias] Rutgers State Univ, Dept Marine & Coastal Sci, New Brunswick, NJ 08901 USA. [White, Angelicque E.] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. [Lam, Phoebe J.] Univ Calif Santa Cruz, Dept Ocean Sci, Santa Cruz, CA 95064 USA. [Milligan, Allen J.] Oregon State Univ, Dept Bot, Corvallis, OR 97331 USA. [Dinniman, Michael S.; Mack, Stefanie] Old Dominion Univ, Ctr Coastal Phys Oceanog, Norfolk, VA 23529 USA. [Hiscock, Michael R.] US Environm Protect Agcy, Off Res & Dev, Washington, DC 20460 USA. [Smith, Walker O., Jr.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA. [Measures, Chris I.] Univ Hawaii, Dept Oceanog, Honolulu, HI 96822 USA. RP Kustka, AB (reprint author), Rutgers State Univ, Dept Earth & Environm Sci, 101 Warren St, Newark, NJ 07102 USA. EM kustka@andromeda.rutgers.edu OI Dinniman, Michael/0000-0001-7519-9278 FU NSF Division of Polar Programs [0839039, 0838921, 0839024, 0839062, 0838980] FX This work was supported through the following awards from the NSF Division of Polar Programs: 0839039 (A.B.K. and J.T.K.), 0838921 (P.J.L.), 0839024 (C.I.M.), 0839062 (J. Sarmiento), and 0838980 (W.O.S.). We are grateful to Mariko Hatta, Ashley New and Katie Watkins-Brandt for assistance during the cruise, and to Laura Palamara for assistance with post-cruise data processing. NR 67 TC 4 Z9 4 U1 6 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0967-0637 EI 1879-0119 J9 DEEP-SEA RES PT I JI Deep-Sea Res. Part I-Oceanogr. Res. Pap. PD NOV PY 2015 VL 105 BP 171 EP 185 DI 10.1016/j.dsr.2015.08.012 PG 15 WC Oceanography SC Oceanography GA CV5ZF UT WOS:000364349300014 ER PT J AU Mazzotta, M Wainger, L Sifleet, S Petty, JT Rashleigh, B AF Mazzotta, Marisa Wainger, Lisa Sifleet, Samantha Petty, J. Todd Rashleigh, Brenda TI Benefit transfer with limited data: An application to recreational fishing losses from surface mining SO ECOLOGICAL ECONOMICS LA English DT Article DE Benefit transfer; Ecosystem services; Meta-analysis; Mountaintop-removal mining; Recreational fishing; Spatial participation model ID WATER-QUALITY IMPROVEMENTS; METAANALYSIS; VALUES; REGRESSION; DISPERSAL; LANDSCAPE; INVASIONS; ECONOMICS; DISTANCE; DEMAND AB The challenges of applying benefit transfer models to policy sites are often underestimated. Analysts commonly need to estimate site-specific effects for areas that lack data on the number of people who use the resource, intensity of use, and other relevant variables. Here, we address issues of applying transfer functions to sites that have sparse or missing data. We present options for estimating data to apply meta-regression models (MRMs) in ways that are scale-appropriate and sensitive to local conditions. Using a case study of the potential lost welfare to freshwater anglers as a result of mountain top coal mining within West Virginia, we integrate: 1) an empirical ecological model of fish community changes; 2) an MRM that relates changes in catch rates to changes in anglers' utility; and 3) a spatial participation analysis that maps trip distribution using multiple survey datasets. We evaluate two scenarios: partial (20%) and full use of existing mine permits. Our conservative estimates of annual welfare loss are $120,500 for the partial scenario and $627,800 for the full scenario, due to changes in recreational fishing catches. These results are sensitive to catch rate assumptions and socio-demographic characteristics that varied widely depending on the spatial scale of measurement. Published by Elsevier B.V. C1 [Mazzotta, Marisa; Rashleigh, Brenda] US EPA, Off Res & Dev, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Wainger, Lisa] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA. [Sifleet, Samantha] RTI Int, Res Triangle Pk, NC 27709 USA. [Petty, J. Todd] W Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. RP Mazzotta, M (reprint author), US EPA, Off Res & Dev, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM mazzotta.marisa@epa.gov OI Wainger, Lisa/0000-0002-3983-8850 FU EPA Regions 3,4 and 5; EPA; DOE; U.S. Environmental Protection Agency FX We would like to thank Hale Thurston, Mat Massey, Kristen Hychka, Wayne Munns, Tim Gleason, Rob Johnston and other participants at the NAREA 2014 conference, and two anonymous reviewers for their helpful comments on this manuscript. We also thank Michael Mangiante, ORISE fellow with EPA's Office of Research and Development and Anna McMurray of the University of Maryland Center for Environmental Science for support with data analysis and figures. We would like to thank Nadia Bukach, Yang Shao, and Kathleen Holm for programming support; and Ron Landy and Lou Reynolds for support of this project. This project was conducted through U.S. Environmental Protection Agency (EPA)'s RESERVE program, in support of EPA Regions 3,4 and 5 with input from Regions 2 and 6. It was supported in part by appointments to the ORISE participant research program supported by an inter-agency agreement between EPA and DOE. Although the research described in this article has been funded by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. This is contribution number ORD-010897 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency. NR 79 TC 0 Z9 0 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8009 EI 1873-6106 J9 ECOL ECON JI Ecol. Econ. PD NOV PY 2015 VL 119 BP 384 EP 398 DI 10.1016/j.ecolecon.2015.09.018 PG 15 WC Ecology; Economics; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology; Business & Economics GA CV9KF UT WOS:000364605400036 ER PT J AU Yoon, T Ma, Y Rhodes, C AF Yoon, Taeyeon Ma, Yongsun Rhodes, Charles TI Individual Heating systems vs. District Heating systems: What will consumers pay for convenience? SO ENERGY POLICY LA English DT Article DE District heating; Residential heating systems; User convenience; Consumer preference; Double-bounded dichotomous choice method ID ENERGY SYSTEM; NATURAL-GAS; HOMEOWNERS; GERMANY AB For Korea's two most popular apartment heating systems - Individual Heating (IH) and District Heating (DH), - user convenience rests heavily on location of the boiler, availability of hot water, administration of the system, and user control of indoor temperature. A double-bounded dichotomous choice method estimates consumer value for convenience, in a hypothetical market. Higher-income more-educated consumers in more expensive apartments prefer DH. Cost-conscious consumers, who use more electrical heating appliances and more actively adjust separate room temperatures, prefer IH. With willingness-to-pay (WTP) defined as the price ratio between IH and DH, 800 survey respondents indicate a WTP of 4.0% for DH over IH. IH users unfamiliar with DH expect little greater convenience (0.1% WTP), whereas the WTP for DH users runs to 7.9%, demonstrating consumer loyalty. Quantified estimates of consumer preference and convenience can inform design of a full-cost-plus pricing system with a price cap. Results here indirectly predict the effect of abolishing regulations that exclusively establish district heating zones. Strategies to foster the many external benefits of DH systems should stress not their lower cost, but convenience, comfort, and safety. Higher installation costs still hamper DH expansion, so policy-makers could set policies to lower cost barriers to entry. (c) 2015 Elsevier Ltd. All rights reserved. C1 [Yoon, Taeyeon; Ma, Yongsun] Korea Energy Econ Inst, Ulsan 681300, South Korea. [Rhodes, Charles] US EPA, Off Water, Washington, DC 20460 USA. RP Yoon, T (reprint author), Korea Energy Econ Inst, 405-11 Jung Gu Jongga Ro, Ulsan 681300, South Korea. EM taeyeon.yoon@keei.re.kr; ysma@keei.re.kr; charlesrrhodes@gmail.com NR 24 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0301-4215 EI 1873-6777 J9 ENERG POLICY JI Energy Policy PD NOV PY 2015 VL 86 BP 73 EP 81 DI 10.1016/j.enpol.2015.06.024 PG 9 WC Energy & Fuels; Environmental Sciences; Environmental Studies SC Energy & Fuels; Environmental Sciences & Ecology GA CV4OJ UT WOS:000364246100007 ER PT J AU Resnik, DB AF Resnik, David B. TI The Censor's Hand: The Misregulation of Human-Subject Research SO HASTINGS CENTER REPORT LA English DT Book Review AB Very few people who read Carl Schneider's The Censor's Hand: The Misregulation of Human-Subject Research (MIT Press, 2015) will have a neutral opinion of his book. Schneider defends the radical thesis that the system of regulating human subjects research is not just broken but deeply misguided and therefore needs to be abolished. While some researchers who are frustrated with the current regime will welcome Schneider's scathing critiques of institutional review boards and the regulations they enforce, those who view the status quo as a necessary, though perhaps flawed, means of protecting human subjects will recoil from his arguments and conclusions. Schneider rejects reform efforts, such as the proposed revisions to the Common Rule, as likely to be short-lived and ineffective. He argues that professional self-regulation and tort law can do a better job of protecting human subjects and advancing research than government regulation. C1 [Resnik, David B.] Natl Inst Environm Hlth Sci, Inst Review Board, Res Triangle Pk, NC 27709 USA. RP Resnik, DB (reprint author), Natl Inst Environm Hlth Sci, Inst Review Board, Res Triangle Pk, NC 27709 USA. FU National Institute for Environmental Health Sciences at the National Institutes of Health FX This research was supported by the intramural program of the National Institute for Environmental Health Sciences at the National Institutes of Health. It does not represent the views of the NIEHS, NIH, or U.S. government. NR 1 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0093-0334 EI 1552-146X J9 HASTINGS CENT REP JI Hastings Cent. Rep. PD NOV-DEC PY 2015 VL 45 IS 6 BP 49 EP 50 DI 10.1002/hast.517 PG 2 WC Ethics; Health Care Sciences & Services; Medical Ethics; Social Sciences, Biomedical SC Social Sciences - Other Topics; Health Care Sciences & Services; Medical Ethics; Biomedical Social Sciences GA CW1YD UT WOS:000364787000015 PM 26556146 ER PT J AU Qi, L Hu, CM Cannizzaro, J Corcoran, AA English, D Le, CF AF Qi, Lin Hu, Chuanmin Cannizzaro, Jennifer Corcoran, Alina A. English, David Le, Chengfeng TI VIIRS Observations of a Karenia brevis Bloom in the Northeastern Gulf of Mexico in the Absence of a Fluorescence Band SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Chlorophyll colored dissolved organic matter (CDOM); fluorescence line height (FLH); harmful algal blooms (HABs); Karenia brevis (K. brevis); Moderate Resolution Imaging Spectroradiometer (MODIS); red-green-chlorophyll-a index (RGCI); Visible Infrared Imager Radiometer Suite (VIIRS) ID OCEAN COLOR SATELLITES; WEST FLORIDA SHELF; IMAGING SPECTROMETER; CHESAPEAKE BAY; RIVER PLUME; CHLOROPHYLL; PHYTOPLANKTON; WATER; MODIS; PERFORMANCE AB The Visible Infrared Imager Radiometer Suite (VIIRS) is not equipped with a fluorescence band, which may affect its ability to detect and quantify harmful algal blooms (HABs) in coastal waters rich in colored dissolved organic matter. Such a deficiency has previously been demonstrated for a bloom of the toxic dinoflagellate Karenia brevis in the northeastern Gulf of Mexico (NEGOM) in summer 2014. Here, using data collected in the field and by VIIRS and Moderate Resolution Imaging Spectroradiometer (MODIS), we show that such a deficiency may be partially overcome using a red-green-chlorophyll-a index (RGCI). A relationship between near-concurrent (+/- 4 hours) VIIRS RGCI (Rrs(672)/Rrs(551)) and field-measured chlorophyll-a (Chla; in mg m(-3)) was developed and evaluated using calibrated Chla obtained by a flowthrough system. A mean relative uncertainty, which was approximately twofold lower than VIIRS OC3M Chla, was obtained for VIIRS RGCI Chla (mean relative error: similar to 56%) over a large range (0.5-20 mg m(-3)). Similar spatial patterns between near-concurrent MODIS-Aqua (MODISA) normalized fluorescence line height (nFLH) and VIIRS RGCI Chla imagery indicate that VIIRS RGCI may be used as a surrogate for MODISA nFLH in the absence of a fluorescence band. The success of this newly developed data product may be partially attributed to the 20-nm bandwidth of the VIIRS 672-nm band (662-682 nm) that covers a portion of the solar stimulated fluorescence region. However, whether such observations from a simple case study can be extended to other turbid coastal or inland waters still remains to be tested. C1 [Qi, Lin; Hu, Chuanmin; Cannizzaro, Jennifer; English, David] Univ S Florida, Coll Marine Sci, St Petersburg, FL 33701 USA. [Corcoran, Alina A.] Florida Fish & Wildlife Conservat Commiss, Fish & Wildlife Res Inst, St Petersburg, FL 33701 USA. [Le, Chengfeng] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Qi, L (reprint author), Univ S Florida, Coll Marine Sci, St Petersburg, FL 33701 USA. EM qilinniglas@163.com FU Ocean Biology and Biogeochemistry Program; Water and Energy Program; Gulf of Mexico Program of the National Aeronautics and Space Administration; National Oceanic and Atmospheric Administration's National Environmental Satellite, Data, and Information Service FX This work was supported in part by the Ocean Biology and Biogeochemistry Program, the Water and Energy Program, and the Gulf of Mexico Program of the National Aeronautics and Space Administration and in part by the National Oceanic and Atmospheric Administration's National Environmental Satellite, Data, and Information Service. NR 35 TC 3 Z9 3 U1 2 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD NOV PY 2015 VL 12 IS 11 BP 2213 EP 2217 DI 10.1109/LGRS.2015.2457773 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA CV4DG UT WOS:000364215500007 ER PT J AU Shi, M Umbach, DM Weinberg, CR AF Shi, Min Umbach, David M. Weinberg, Clarice R. TI Using parental phenotypes in case-parent studies SO GENETIC EPIDEMIOLOGY LA English DT Meeting Abstract CT Annual Meeting of the International-Genetic-Epidemiology-Society (IGES) CY OCT 04-06, 2015 CL Baltimore, MD SP Int Genet Epidemiol Soc C1 [Shi, Min; Umbach, David M.; Weinberg, Clarice R.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0741-0395 EI 1098-2272 J9 GENET EPIDEMIOL JI Genet. Epidemiol. PD NOV PY 2015 VL 39 IS 7 MA 135 BP 580 EP 580 PG 1 WC Genetics & Heredity; Mathematical & Computational Biology SC Genetics & Heredity; Mathematical & Computational Biology GA CU2FZ UT WOS:000363340500139 ER PT J AU Gamas, J Dodder, R Loughlin, D Gage, C AF Gamas, Julia Dodder, Rebecca Loughlin, Dan Gage, Cynthia TI Role of future scenarios in understanding deep uncertainty in long-term air quality management SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID ENERGY SCENARIOS; CLIMATE-CHANGE; UNITED-STATES; EMISSIONS; METHODOLOGY; PATHWAYS; IMPACTS; POLICY; US AB The environment and its interactions with human systems, whether economic, social, or political, are complex. Relevant drivers may disrupt system dynamics in unforeseen ways, making it difficult to predict future conditions. This kind of "deep uncertainty" presents a challenge to organizations faced with making decisions about the future, including those involved in air quality management. Scenario Planning is a structured process that involves the development of narratives describing alternative future states of the world, designed to differ with respect to the most critical and uncertain drivers. The resulting scenarios are then used to understand the consequences of those futures and to prepare for them with robust management strategies. We demonstrate a novel air quality management application of Scenario Planning. Through a series of workshops, important air quality drivers were identified. The most critical and uncertain drivers were found to be "technological development" and "change in societal paradigms." These drivers were used as a basis to develop four distinct scenario storylines. The energy and emissions implications of each storyline were then modeled using the MARKAL energy system model. NOx emissions were found to decrease for all scenarios, largely a response to existing air quality regulations, whereas SO2 emissions ranged from 12% greater to 7% lower than 2015 emissions levels. Future-year emissions differed considerably from one scenario to another, however, with key differentiating factors being transition to cleaner fuels and energy demand reductions. Implications: Application of scenarios in air quality management provides a structured means of sifting through and understanding the dynamics of the many complex driving forces affecting future air quality. Further, scenarios provide a means to identify opportunities and challenges for future air quality management, as well as a platform for testing the efficacy and robustness of particular management options across wide-ranging conditions. C1 [Gamas, Julia; Dodder, Rebecca; Loughlin, Dan; Gage, Cynthia] US EPA, Res Triangle Pk, NC 27711 USA. RP Gamas, J (reprint author), US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gamas.julia@epa.gov NR 66 TC 0 Z9 0 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD NOV PY 2015 VL 65 IS 11 BP 1327 EP 1340 DI 10.1080/10962247.2015.1084783 PG 14 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CU2ET UT WOS:000363336900006 PM 26484975 ER PT J AU Heindel, JJ Newbold, R Schug, TT AF Heindel, Jerrold J. Newbold, Retha Schug, Thaddeus T. TI Endocrine disruptors and obesity SO NATURE REVIEWS ENDOCRINOLOGY LA English DT Review ID EPIGENETIC TRANSGENERATIONAL INHERITANCE; POLYBROMINATED DIPHENYL ETHERS; EARLY-LIFE EXPOSURE; MESENCHYMAL STEM-CELLS; BISPHENOL-A EXPOSURE; ORAL DOSE TOXICITY; IN-UTERO EXPOSURE; AIR-POLLUTION; PRENATAL EXPOSURE; BODY-WEIGHT AB The increasing incidence of obesity is a serious global public health challenge. Although the obesity epidemic is largely fueled by poor nutrition and lack of exercise, certain chemicals have been shown to potentially have a role in its aetiology. A substantial body of evidence suggests that a subclass of endocrine-disrupting chemicals (EDCs), which interfere with endocrine signalling, can disrupt hormonally regulated metabolic processes, especially if exposure occurs during early development. These chemicals, so-called 'obesogens' might predispose some individuals to gain weight despite their efforts to limit caloric intake and increase levels of physical activity. This Review discusses the role of EDCs in the obesity epidemic, the latest research on the obesogen concept, epidemiological and experimental findings on obesogens, and their modes of action. The research reviewed here provides knowledge that health scientists can use to inform their research and decision-making processes. C1 [Heindel, Jerrold J.; Schug, Thaddeus T.] Natl Inst Environm Sci, Div Extramural Res & Training, Populat Hlth Branch, Res Triangle Pk, NC 27709 USA. [Newbold, Retha] Natl Inst Environm Hlth Sci, Div Natl Toxicol Program, Natl Inst Hlth, Res Triangle Pk, NC 27709 USA. RP Heindel, JJ (reprint author), Natl Inst Environm Sci, Div Extramural Res & Training, Populat Hlth Branch, POB 12233, Res Triangle Pk, NC 27709 USA. EM J.J.H.heindelj@niehs.nih.gov NR 139 TC 25 Z9 25 U1 17 U2 84 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1759-5029 EI 1759-5037 J9 NAT REV ENDOCRINOL JI Nat. Rev. Endocrinol. PD NOV PY 2015 VL 11 IS 11 BP 653 EP 661 DI 10.1038/nrendo.2015.163 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CU4CQ UT WOS:000363474400008 PM 26391979 ER PT J AU Salazar, KD Brinkerhoff, CJ Lee, JS Chiu, WA AF Salazar, Keith D. Brinkerhoff, Christopher J. Lee, Janice S. Chiu, Weihsueh A. TI Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Gasoline oxygenates; Internal dosimetrics; Dose-response; Physiologically based pharmacokinetic model ID BUTYL ETHER; PHARMACOKINETIC MODEL; FISCHER-344 RATS; GASOLINE ETHERS; F344 RATS; METHYL; EXPOSURE; ALCOHOL; HEPATOTUMORIGENICITY; ALPHA-2U-GLOBULIN AB Subchronic and chronic studies in rats of the gasoline oxygenates ethyl tert-butyl ether (ETBE) and tert-butanol (TBA) report similar noncancer kidney and liver effects but differing results with respect to kidney and liver tumors. Because TBA is a major metabolite of ETBE, it is possible that TBA is the active toxic moiety in all these studies, with reported differences due simply to differences in the internal dose. To test this hypothesis, a physiologically-based pharmacokinetic (PBPK) model was developed for ETBE and TBA to calculate internal dosimetrics of TBA following either TBA or ETBE exposure. This model, based on earlier PBPK models of methyl tert-butyl ether (MTBE), was used to evaluate whether kidney and liver effects are consistent across routes of exposure, as well as between ETBE and TBA studies, on the basis of estimated internal dose. The results demonstrate that noncancer kidney effects, including kidney weight changes, urothelial hyperplasia, and chronic progressive nephropathy (CPN), yielded consistent dose-response relationships across routes of exposure and across ETBE and TBA studies using TBA blood concentration as the dose metric. Relative liver weights were also consistent across studies on the basis of TBA metabolism, which is proportional to TBA liver concentrations. However, kidney and liver tumors were not consistent using any dose metric. These results support the hypothesis that TBA mediates the noncancer kidney and liver effects following ETBE administration; however, additional factors besides internal dose are necessary to explain the induction of liver and kidney tumors. Published by Elsevier Inc. C1 [Salazar, Keith D.; Lee, Janice S.] US EPA, Tox Pathways Branch, IRIS Div, NCEA,ORD, Washington, DC 20460 USA. [Brinkerhoff, Christopher J.] US EPA, Risk Assessment Div, OPPT, OCSPP, Washington, DC 20460 USA. [Chiu, Weihsueh A.] Texas A&M Univ, Dept Vet Integrat Biosci, Coll Vet Med & Biomed Sci, College Stn, TX 77843 USA. RP Salazar, KD (reprint author), US EPA, Tox Pathways Branch, IRIS Div, NCEA,ORD, Washington, DC 20460 USA. EM Salazar.keith@epa.gov; Brinkerhoff.Chris@epa.gov; Lee.JaniceS@epa.gov; wchiu@cvm.tamu.edu OI Salazar, Keith/0000-0002-0086-9916 NR 40 TC 0 Z9 0 U1 3 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD NOV 1 PY 2015 VL 288 IS 3 BP 439 EP 452 DI 10.1016/j.taap.2015.08.015 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CT8RL UT WOS:000363083600016 PM 26341290 ER PT J AU Mariosa, D Kamel, F Bellocco, R Ye, W Fang, F AF Mariosa, D. Kamel, F. Bellocco, R. Ye, W. Fang, F. TI Association between diabetes and amyotrophic lateral sclerosis in Sweden SO EUROPEAN JOURNAL OF NEUROLOGY LA English DT Article DE amyotrophic lateral sclerosis; diabetes; epidemiology; insulin dependence; metabolic and endocrine disorders; motor neuron disease; neurological disorders; neuromuscular diseases; research methods ID RISK; MELLITUS AB Background and purposeEnergy metabolism is altered in patients with amyotrophic lateral sclerosis (ALS) but the role of diabetes is largely unknown. MethodsA population-based case-control study was conducted of 5108 ALS cases and 25540 individually matched population controls during 1991-2010. Information on ALS and pre-existing diabetes was retrieved from the Swedish Patient Register to explore the association of ALS with diabetes overall and with insulin-dependent or non-insulin-dependent diabetes specifically. Variation of the association by diabetes duration and age was also studied. ResultsIn total, 224 ALS cases (4.39%) and 1437 controls (5.63%) had diabetes before the index date, leading to an overall inverse association between diabetes and ALS risk [odds ratio (OR)0.79, 95% confidence interval (CI)0.68-0.91]. The association was strong for non-insulin-dependent diabetes (OR0.66, 95% CI0.53-0.81) but not for insulin-dependent diabetes (OR0.83, 95% CI0.60-1.15) and varied as a function of diabetes duration, with the strongest association observed around 6years after first ascertainment of diabetes. The association was age-specific; the inverse association was noted only amongst individuals aged 70 or older. In contrast, for younger individuals (<50years), pre-existing insulin-dependent diabetes was associated with a higher ALS risk (OR5.38, 95% CI1.87-15.51). ConclusionsOur study suggests that there is an association between diabetes and ALS, and highlights the importance of taking into account age, insulin dependence and diabetes duration. Future studies should explore whether the association is independent of body mass index. Click to view the accompanying paper in this issue. C1 [Mariosa, D.; Bellocco, R.; Ye, W.; Fang, F.] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden. [Kamel, F.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. [Bellocco, R.] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy. RP Mariosa, D (reprint author), Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, S-17177 Stockholm, Sweden. EM Daniela.mariosa@ki.se OI Fang, Fang/0000-0002-3310-6456; Kamel, Freya/0000-0001-5052-6615 FU Swedish Research Council; Swedish Society for Medical Research; Swedish Research Council for Health, Working Life and Welfare; Karolinska Institutet Partial Finance for PhD Students; NIH [Z01 ES 049005] FX This study was funded by the Swedish Research Council, the Swedish Society for Medical Research, the Swedish Research Council for Health, Working Life and Welfare, the Karolinska Institutet Partial Finance for PhD Students, and the Intramural Research Program of the NIH (Z01 ES 049005). NR 25 TC 10 Z9 11 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1351-5101 EI 1468-1331 J9 EUR J NEUROL JI Eur. J. Neurol. PD NOV PY 2015 VL 22 IS 11 BP 1436 EP 1442 DI 10.1111/ene.12632 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CT2YR UT WOS:000362673300004 PM 25600257 ER PT J AU Zeller, L AF Zeller, Lori TI Potential changes in transportation patterns of New York Islanders fans due to stadium relocation SO TRANSPORTATION LA English DT Article DE Public transit; Mode shift; Accessibility; Survey; Recreational travel ID BUILT ENVIRONMENT; TRAVEL AB In 2015 the New York Islanders, a professional men's ice hockey team in the National Hockey League, will relocate to an arena with more transportation options for fans. The team currently plays at Nassau Coliseum in Uniondale, Long Island, NY, with limited public transportation access. They will move 23 miles west to the Barclays Center, an arena in the heart of Brooklyn, NY, with many public transportation options. This study examined fan characteristics which may influence their likelihood of attending Islanders games at the Barclays Center, including familiarity with public transportation, frequency of game attendance, and demographic factors. An online survey of Islanders fans captured fans' transportation behaviors when traveling to Islanders games at Nassau Coliseum and their projected frequency of attendance after the move, among other variables. Binary and ordered logistic regression models tested the significance of fan characteristics on the likelihood they attended a pre-season Islanders game held at the Barclays Center in September, 2013, and on how frequently respondents reported they will attend future games in Brooklyn. For both models, fans who use regional rail every workday, compared to those who do not, were significantly more likely to have attended the pre-season game and to report they will attend future games. Transit-use variables performed stronger in models than variables representing fans' work locations. The results exemplify the importance of familiarity with public transportation options when making mode choice decisions, bolstering the importance of transportation demand management strategies when opening new or relocating existing large event venues. C1 US EPA, Off Sustainable Communities, ORISE, Washington, DC 20460 USA. RP Zeller, L (reprint author), US EPA, Off Sustainable Communities, ORISE, 1200 Penn Ave,NW Mailcode 1807T, Washington, DC 20460 USA. EM Zeller.Lori@epa.gov FU University Transportation Research Center Region 2 FX This research was made possible by a scholarship from the University Transportation Research Center Region 2. Thank you for this wonderful opportunity. Thank you to all the people who supported this project: Robert Noland, Deva Deka, Mitch Zeller, Paula Zeller, Emily Zeller, Ross Schwarzber, Radha Jagannathan, Orin Puniello, Marc Weiner, Leighann Kimber, Swetha Ramkumar, Joseph Steindam, Kevin Schultz, Rob McGowan, Lisa from IslanderMania, Dan Schack, and all the Islanders fans who responded to the survey and sent personal anecdotes. NR 10 TC 0 Z9 0 U1 3 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0049-4488 EI 1572-9435 J9 TRANSPORTATION JI Transportation PD NOV PY 2015 VL 42 IS 6 BP 951 EP 966 DI 10.1007/s11116-015-9652-8 PG 16 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA CT6CS UT WOS:000362899600004 ER PT J AU Van Meter, RJ Glinski, DA Henderson, WM Garrison, AW Cyterski, M Purucker, ST AF Van Meter, Robin J. Glinski, Donna A. Henderson, W. Matthew Garrison, A. Wayne Cyterski, Mike Purucker, S. Thomas TI Pesticide Uptake Across the Amphibian Dermis Through Soil and Overspray Exposures SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID FROGS LITHOBATES-CLAMITANS; ACUTE TOXICITY; LEGGED FROGS; TERRESTRIAL; GLYPHOSATE; CALIFORNIA; HERBICIDE; DECLINES; CONSERVATION; FORMULATIONS AB For terrestrial amphibians, accumulation of pesticides through dermal contact is a primary route of exposure in agricultural landscapes and may be contributing to widespread amphibian declines. To show pesticide transfer across the amphibian dermis at permitted label application rates, our study was designed to measure pesticide body burdens after two simulated exposure scenarios. We compared direct exposures, where amphibians were present when spraying occurred, to indirect exposures, where amphibians were exposed to soils after pesticide application. During summer 2012, we reared barking (Hyla gratiosa) and green treefrogs (H. cinerea) through 60-90 days post-metamorphosis at a United States Environmental Protection Agency research laboratory. We tested exposure for 8 h to five pesticide active ingredients (imidacloprid, atrazine, triadimefon, fipronil, or pendimethalin) in glass aquaria lined with soil in the laboratory. We quantified total pesticide body burden and soil concentrations using liquid chromatography-mass spectrometry. All individuals in both treatments had measurable body burdens at the end of the study. A randomized block design analysis of variance (n = 18) showed that body burdens (p = 0.03) and bioconcentration factors (BCFs) (p = 0.01) were significantly greater in the direct overspray treatment relative to the indirect soil spray treatment for both species and tested pesticides. BCFs ranged from 0.1 to 1.16 and from 0.013 to 0.78 in the direct and indirect treatments, respectively. Our study shows dermal uptake for multiple pesticides from both direct spray and indirect soil exposures and provides empirical support for the degree to which terrestrial phase amphibians have higher body burdens after overspray pesticide exposure. C1 [Van Meter, Robin J.] US EPA, Oak Ridge Inst Sci & Educ, Athens, GA 30613 USA. [Glinski, Donna A.] US EPA, Student Serv Author Contractor, Athens, GA 30605 USA. [Henderson, W. Matthew; Garrison, A. Wayne; Cyterski, Mike; Purucker, S. Thomas] US EPA, Ecosyst Res Div, Athens, GA 30605 USA. RP Van Meter, RJ (reprint author), Washington Coll, Toll Sci Ctr SG20, Chestertown, MD 21620 USA. EM rvanmeter2@washcoll.edu FU USEPA Ecosystems Research Division, Athens, GA [DW8992298301] FX We gratefully acknowledge the efforts of Jimmy Avants for assistance in developing our amphibian tissue extraction protocol. The USEPA Office of Pesticide Programs provided valuable feedback on study design. Thanks to Fran Rauschenberg and Craig Barber for manuscript review and edits. Many hours of field assistance with tadpoles and metamorphs was given by Craig Barber, Tao Hong, Yin Gu, Katie Price, and Marcia Snyder. This IACUC protocol (A2012 05-018-Y1-A0) received approval from the University of Georgia Institutional Animal Care and Use Committee. This research was supported in part by an appointment to the Post-doctoral Research Program at the USEPA Ecosystems Research Division, Athens, GA, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW8992298301 between the United States Department of Energy and the United States Environmental Protection Agency. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the USEPA. NR 41 TC 2 Z9 2 U1 12 U2 35 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 EI 1432-0703 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD NOV PY 2015 VL 69 IS 4 BP 545 EP 556 DI 10.1007/s00244-015-0183-2 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CT2WT UT WOS:000362666700017 PM 26135301 ER PT J AU Wigand, C Davey, E Johnson, R Sundberg, K Morris, J Kenny, P Smith, E Holt, M AF Wigand, Cathleen Davey, Earl Johnson, Roxanne Sundberg, Karen Morris, James Kenny, Paul Smith, Erik Holt, Matt TI Nutrient Effects on Belowground Organic Matter in a Minerogenic Salt Marsh, North Inlet, SC SO ESTUARIES AND COASTS LA English DT Article DE Roots; Rhizomes; Nutrient enrichment; Salt marsh; Organic matter; Below ground structure; Minerogenic marsh; Organogenic marsh; Computer-aided tomography ID RELATIVE SEA-LEVEL; LONG-ISLAND SOUND; SPARTINA-ALTERNIFLORA; SOUTH-CAROLINA; CARBON BALANCE; URBAN ESTUARY; NEW-ENGLAND; RESPONSES; EUTROPHICATION; RESPIRATION AB Soil organic matter, roots, rhizomes, and carbon dioxide (CO2) emission rates were examined in minerogenic marshes of the North Inlet Estuary, a system dominated by sediment depositional processes and typical of the Southeast USA. Three marsh sites were sampled: a long-term nutrient enrichment experiment at Goat Island; the high marsh, low marsh, and creekbank of Crab Haul Creek, a fringing marsh that only receives drainage from a forested watershed; and three creekbank locations in Debidue Creek, which receives drainage from a residential and golf course development situated at its headwaters. Goat Island responses to 12 years of nutrient fertilization were an increase in soil organic matter (OM), an increase in number of rhizomes, enlarged rhizome diameters, and increased CO2 emission rates. At soil depths of 10-20 cm, all Debidue creekbank locations had significantly more rhizomes than the reference Crab Haul creekbank. The rhizome diameters at the mid and upper Debidue creekbank locations were significantly larger than the Debidue mouth and reference Crab Haul creekbank. The upper Debidue and the Crab Haul creekbanks had similar soil percent OM, which was significantly greater than the mid Debidue, which was greater than the Debidue mouth. CO2 emission rates at the fertilized Goat Island plots were similar in magnitude to the upper Debidue and significantly greater than the Goat Island control plots and the reference Crab Haul Creek. Inputs of sediment in marshes dominated by depositional processes may buffer the system from adverse effects of nutrient exposure, while increases in soil OM and rhizomes in response to nutrients may contribute to peat formation. C1 [Wigand, Cathleen; Davey, Earl; Johnson, Roxanne; Holt, Matt] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA. [Sundberg, Karen; Morris, James; Kenny, Paul] Univ S Carolina, Belle W Baruch Inst Marine & Coastal Sci, Columbia, SC 29208 USA. [Smith, Erik] North Inlet Winyah Bay Natl Estuarine Res Reserve, Georgetown, SC 29442 USA. RP Wigand, C (reprint author), US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA. EM wigand.cathleen@epa.gov FU Baruch Institute for Marine and Coastal Science; National Science Foundation LTREB program FX C. Wigand is grateful for a visiting scientist award (2007-2008) from the Baruch Institute for Marine and Coastal Science and support from the National Science Foundation LTREB program, which supported part of this study. We thank Tracy Buck (BMFL) for assistance in the field, Rex Tien and Alana Hanson for assistance in the lab, and Morgan Cencer for assistance with data analyses. Mention of trade names or commercial products does not constitute endorsement or recommendation for use by the US Environmental Protection Agency. This report is ORD Tracking Number ORD-007374 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency. The report has been reviewed technically by the US EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency. NR 46 TC 5 Z9 5 U1 7 U2 32 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD NOV PY 2015 VL 38 IS 6 BP 1838 EP 1853 DI 10.1007/s12237-014-9937-8 PG 16 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CT1SE UT WOS:000362580300003 ER PT J AU Green, L Lapointe, BE Gawlik, DE AF Green, Lauri Lapointe, Brian E. Gawlik, Dale E. TI Winter Nutrient Pulse and Seagrass Epiphyte Bloom: Evidence of Anthropogenic Enrichment or Natural Fluctuations in the Lower Florida Keys? SO ESTUARIES AND COASTS LA English DT Article DE Epiphyte; Florida Keys; Isotope; Macroalgae; Nutrient enrichment; Seagrass ID CORAL-REEF COMMUNITIES; THALASSIA-TESTUDINUM; SOUTH FLORIDA; PHYTOPLANKTON GROWTH; ECOSYSTEM STRUCTURE; COASTAL ECOSYSTEMS; INORGANIC NITROGEN; STABLE-ISOTOPES; BAY; PHOSPHORUS AB Nutrient enrichment continues to disrupt marine ecosystem function worldwide. Assessing eutrophication in seagrass ecosystems such as the Great White Heron National Wildlife Refuge (GWHNWR), Florida Keys is critical for protecting the diverse community that depends on the intertidal and subtidal seagrass beds. We quantified water column nutrients, chlorophyll a, tissue nutrients in macroalgae and Thalassia testudinum, and epiphyte percent cover on seagrasses on tidal flats seasonally over 1 year at three sites: Howe Key, Water Keys, and Upper Harbor Key. Water column nutrients (total nitrogen, total phosphorus, nitrate-nitrite, ammonium, dissolved inorganic nitrogen, dissolved organic nitrogen, soluble reactive phosphorus, dissolved organic phosphorus) increased from fall to winter at Water Keys. These increased nutrients coincided with a bloom of the epiphyte Spyridia filamentosa on seagrasses that exceeded 40 % cover at Water Keys and Upper Harbor Key in two consecutive seasons. Seagrasses at all sites had chronic percent cover of small epiphytes exceeding 60 %. Additionally, low delta C-13 in T. testudinum tissues at Upper Harbor Key compared to the other sites suggested variations in carbon sources across the study area. Spatial patterns in macrophyte nitrogen-to-phosphorus (N:P) ratios point to sources of nutrients from the inhabited islands of the Keys and from the Gulf of Mexico. Water column total nitrogen and total phosphorus concentrations exceeded the numeric nutrient criteria for the study area suggesting that the area should be monitored closely. C1 [Green, Lauri; Lapointe, Brian E.] Florida Atlantic Univ, Harbor Branch Oceanog Inst, Ft Pierce, FL 34946 USA. [Gawlik, Dale E.] Florida Atlantic Univ, Environm Sci Program, Boca Raton, FL 33431 USA. RP Green, L (reprint author), US EPA, 2111 SE Marine Sci Dr, Newport, OR 97366 USA. EM cnidaria79@gmail.com; blapoin1@fau.edu; dgawlik@fau.edu FU U.S. Fish and Wildlife Service, Florida Atlantic University; Save Our Seas Florida State License Plate program; Great White Heron National Wildlife Refuge FX Funding for this study was provided by the U.S. Fish and Wildlife Service, Florida Atlantic University and the Save Our Seas Florida State License Plate program and the Great White Heron National Wildlife Refuge. This is contribution number 1949 from Florida Atlantic University's Harbor Branch Oceanographic Institute. We appreciate the support of the staff at the Florida Keys Refuge complex, especially Thomas Wilmers and Phillip Hughes, and Mote Marine Lab on Summerland Key. We thank the four reviewers for their constructive feedback that greatly improved this manuscript. We acknowledge the National Oceanographic Atmospheric Agency (NOAA) and the National Ocean Service for use of the DEM. We are grateful to Leonardo Calle, Kelsey Doyle, Laura Herren, and Stacey Kalwies-Foster for their assistance in the field. NR 89 TC 0 Z9 0 U1 10 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD NOV PY 2015 VL 38 IS 6 BP 1854 EP 1871 DI 10.1007/s12237-015-9940-8 PG 18 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CT1SE UT WOS:000362580300004 ER PT J AU Russell, M Greening, H AF Russell, Marc Greening, Holly TI Estimating Benefits in a Recovering Estuary: Tampa Bay, Florida (vol 38, pg s9, 2015) SO ESTUARIES AND COASTS LA English DT Correction C1 [Russell, Marc] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32563 USA. [Greening, Holly] Tampa Bay Estuary Program, St Petersburg, FL 33701 USA. RP Russell, M (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32563 USA. EM Russell.Marc@epamail.epa.gov NR 1 TC 0 Z9 0 U1 5 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD NOV PY 2015 VL 38 IS 6 BP 2366 EP 2367 DI 10.1007/s12237-015-9946-2 PG 2 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CT1SE UT WOS:000362580300040 ER PT J AU Weaver, PC Lazorchak, JM Struewing, KA DeCelles, SJ Funk, DH Buchwalter, DB Johnson, BR AF Weaver, Paul C. Lazorchak, James M. Struewing, Katherine A. DeCelles, Susanna J. Funk, David H. Buchwalter, David B. Johnson, Brent R. TI Part 1: Laboratory culture of Centroptilum triangulifer (Ephemeroptera: Baetidae) using a defined diet of three diatoms SO CHEMOSPHERE LA English DT Article DE Benthic macroinvertebrates; Water quality criteria; Ecotoxicology; Parthenogenetic mayfly; Culture method; Diatoms ID CLOEON-TRIANGULIFER; SALINITY TOLERANCES; TOXICITY; CADMIUM; MACROINVERTEBRATES; STREAMS; ZINC; BIOACCUMULATION; AUSTRALIA; RESPONSES AB Development of methods for assessing exposure and effects of waterborne toxicants on stream invertebrate species is important to elucidate environmentally relevant information. Current protocols for freshwater invertebrate toxicity testing almost exclusively utilize cladocerans, amphipods or chironomids rather than the more typical aquatic insect taxa found in lotic systems. Centroptilum triangulifer is a parthenogenetic mayfly occurring in depositional habitats of streams and rivers of the Eastern U.S. and Canada. C. triangulifer is an ideal stream insect for toxicity testing under field and laboratory conditions because of its short life cycle, parthenogenetic mode of reproduction, and it represents a group considered sensitive to environmental stressors. In this study, a colony of C triangulifer was reared using a defined diet of three diatoms, Mayamaea atomus var. permitis, Nitzschia cf. pusilla, and Achnanthidium minutissimum. Percent survival (>= 80%), fecundity measurements (>= 1000 eggs) and pre-egg laying weights were used as indicators of overall colony health and fitness in our laboratory water (Lab-line) and in Moderately Hard Reconstituted Water (MHRW). Lab-line reared C. triangulifer had average survival rate of 92.69% for eleven generations and 82.99% over thirteen generations. MHRW reared C triangulifer had an average survival rate of 80.65% for four generations and three generations of fecundities greater than 1000 eggs per individual. Pre-egg laying weight and fecundity were highly correlated and a best-fit model equation was derived to estimate egg counts for future generations. Establishment of this culturing protocol provides a more ecologically relevant species for toxicity testing and aids in further stressor identification for stream bioassessments. Published by Elsevier Ltd. C1 [Weaver, Paul C.; Struewing, Katherine A.; DeCelles, Susanna J.] McConnell Grp, Cincinnati, OH 45268 USA. [Lazorchak, James M.; Johnson, Brent R.] US EPA, Cincinnati, OH 45268 USA. [Funk, David H.] Stroud Water Res Ctr, Avondale, PA USA. [Buchwalter, David B.] N Carolina State Univ, Raleigh, NC 27695 USA. RP Lazorchak, JM (reprint author), US EPA, 26 W MLK Blvd, Cincinnati, OH 45268 USA. EM lazorchak.jim@epa.gov OI Lazorchak, James/0000-0002-7354-7571 NR 35 TC 0 Z9 0 U1 4 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2015 VL 139 BP 589 EP 596 DI 10.1016/j.chemosphere.2014.04.092 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CS1ZQ UT WOS:000361868000076 PM 24894451 ER PT J AU Struewing, KA Lazorchak, JM Weaver, PC Johnson, BR Funk, DH Buchwalter, DB AF Struewing, Katherine A. Lazorchak, James M. Weaver, Paul C. Johnson, Brent R. Funk, David H. Buchwalter, David B. TI Part 2: Sensitivity comparisons of the mayfly Centroptilum triangulifer to Ceriodaphnia dubia and Daphnia magna using standard reference toxicants; NaCl, KCl and CuSO4 SO CHEMOSPHERE LA English DT Article DE Mayfly; Comparative toxicity; NaCl; KCl; CuSO4 ID CLOEON-TRIANGULIFER; DIVALENT METALS; TOXICITY; CADMIUM; EPHEMEROPTERA; DIETARY; BIOACCUMULATION; ORGANISMS; CHLORDANE; RESPONSES AB Criteria for establishing water quality standards that are protective for 95% of the native species are generally based upon laboratory toxicity tests. These tests utilize common model organisms that have established test methods. However, for invertebrates these species represent mostly the zooplankton community and are not inclusive of all taxa. In order to examine a potential under-representation in emerging aquatic invertebrates the US Environmental Protection Agency has cultured a parthenogenetic mayfly, Centroptilum triangulifer (Ephemeroptera: Baetidae). This study established a 48 h acute and a 14-day short-term chronic testing procedure for C. triangulifer and compared its sensitivity to two model invertebrates, Ceriodaphnia dubia and Daphnia magna. Toxicity tests were conducted to determine mortality and growth effects using standard reference toxicants: NaCl, KCl and CuSO4. In 48-h acute tests, the average LC50 for the mayfly was 659 mg L-1 NaCl, 1957 mg L-1 KCl, and 11 mu g L-1 CuSO4. IC25 values, using dry weight as the endpoint, were 228 mg L-1 NaCl, 356 mg L-1 KCl and 5 mu g L-1 CuSO4. C triangulifer was the most sensitive species in NaCl acute and chronic growth tests. At KCl concentrations tested, C. triangulifer was less sensitive for acute tests but was equally or more sensitive than C. dubia and D. magna for growth measurements. This study determined C. triangulifer has great potential and benefits for use in ecotoxicological studies. Published by Elsevier Ltd. C1 [Struewing, Katherine A.; Weaver, Paul C.] McConnell Grp, Cincinnati, OH 45268 USA. [Lazorchak, James M.; Johnson, Brent R.] US EPA, Cincinnati, OH 45268 USA. [Funk, David H.] Stroud Water Res Ctr, Avondale, PA USA. [Buchwalter, David B.] N Carolina State Univ, Raleigh, NC 27695 USA. RP Lazorchak, JM (reprint author), US EPA, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM Lazorchak.jim@epa.gov NR 26 TC 5 Z9 5 U1 4 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2015 VL 139 BP 597 EP 603 DI 10.1016/j.chemosphere.2014.04.096 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA CS1ZQ UT WOS:000361868000077 PM 24932778 ER PT J AU Solecki, R Rauch, M Gall, A Buschmann, J Clark, R Fuchs, A Kan, HD Heinrich, V Kellner, R Knudsen, TB Li, WH Makris, SL Ooshima, Y Paumgartten, F Piersma, AH Schonfelder, G Oelgeschlager, M Schaefer, C Shiota, K Ulbrich, B Ding, XC Chahoud, I AF Solecki, Roland Rauch, Martina Gall, Andrea Buschmann, Jochen Clark, Ruth Fuchs, Antje Kan, Haidong Heinrich, Verena Kellner, Rupert Knudsen, Thomas B. Li, Weihua Makris, Susan L. Ooshima, Yojiro Paumgartten, Francisco Piersma, Aldert H. Schoenfelder, Gilbert Oelgeschlaeger, Michael Schaefer, Christof Shiota, Kohei Ulbrich, Beate Ding, Xuncheng Chahoud, Ibrahim TI Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014 SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE Malformation; Variation; Grey zone anomalies; Human anomalies; Developmental toxicology; Reproductive toxicology; Terminology; Harmonization ID FETAL OBSERVATIONS; CLASSIFICATION AB This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes. (C) 2015 Published by Elsevier Inc. C1 [Solecki, Roland; Rauch, Martina; Gall, Andrea; Heinrich, Verena; Schoenfelder, Gilbert; Oelgeschlaeger, Michael] Fed Inst Risk Assessment, Hannover, Germany. [Buschmann, Jochen; Kellner, Rupert] Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany. [Schoenfelder, Gilbert; Schaefer, Christof; Chahoud, Ibrahim] Charite, D-13353 Berlin, Germany. [Clark, Ruth] Ruth Clark Associates Ltd, Scunthorpe, England. [Fuchs, Antje] Covance Labs GmbH, Munster, Germany. [Kan, Haidong] Fudan Univ, Shanghai 200433, Peoples R China. [Knudsen, Thomas B.; Makris, Susan L.] US EPA, Washington, DC 20460 USA. [Li, Weihua; Ding, Xuncheng] Shanghai Inst Planned Parenthood Res, Shanghai, Peoples R China. [Ooshima, Yojiro] Japanese Teratol Soc, Kagoshima, Japan. [Paumgartten, Francisco] Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil. [Piersma, Aldert H.] RIVM Bilthoven, Bilthoven, Netherlands. [Shiota, Kohei] Shiga Univ Med Sci, Shiga, Japan. RP Heinrich, V (reprint author), Bundesinst Risikobewertung, Max Dohrn Str 8-10, D-10589 Berlin, Germany. EM devtox@bfr.bund.de OI Schonfelder, Gilbert/0000-0001-6134-1990 NR 18 TC 0 Z9 0 U1 2 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD NOV PY 2015 VL 57 BP 140 EP 146 DI 10.1016/j.reprotox.2015.06.046 PG 7 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA CQ0XQ UT WOS:000360322300016 PM 26073002 ER PT J AU Kim, C Panditi, VR Gardinali, PR Varma, RS Kim, H Sharma, VK AF Kim, Chansik Panditi, Venkata R. Gardinali, Piero R. Varma, Rajender S. Kim, Hyunook Sharma, Virender K. TI Ferrate promoted oxidative cleavage of sulfonamides: Kinetics and product formation under acidic conditions SO CHEMICAL ENGINEERING JOURNAL LA English DT Article DE Ferrate; Oxidation; SMX; Kinetics; Oxidized products; Cleavage ID WASTE-WATER TREATMENT; BETA-LACTAM ANTIBIOTICS; REMOVAL; PHARMACEUTICALS; SULFAMETHOXAZOLE; CHLORINE; TRANSFORMATION; TECHNOLOGIES; PERMANGANATE; MECHANISMS AB Sulfonamide-based antibiotics are often detected in surface water and secondary wastewater effluent and pose an eminent threat for the development of antibiotic resistance bacteria and genes in aquatic environment. This paper presents the kinetics and stoichiometry of the oxidation of sulfonamides (sulfaguanidine, sulfisoxazole, sulfamethizole, sulfamethoxazole (SMX), sulfamethazine, and sulfadimethoxine) by ferrate(VI) (FeO42-, Fe(VI)) in the acidic to basic pH range (2.0-9.6); apparent second-order rate constants (k(app), M s(-1)) decreased non-linearly with increase in pH. The specific rate constants for the individual Fe(VI) species (H3FeC4+, H2FeO4, HFeO4-, and FeO4-) were determined using acid-base equilibria of Fe(VI) and sulfonamides. The reactivity order of Fe(VI) species with the neutral sulfonamide was H3FeO4+>H2FeO4 > HFeO4-, which generally explained the pH dependence behavior of rate constants. Detailed studies regarding the resultant oxidized products (OPs) using liquid chromatography-mass spectrometry/mass spectrometry were performed for oxidation of SMX at different molar ratios of Fe(VI) to SMX (i.e., 1.0-15) and at different pH's (i.e., 4.0, 7.0, and 9.0); oxidative degradative products include 3-amino-5-methylisoxazole, and hydroxyl-, hydroxylamine-, nitroso-, and nitro-derivatives of SMX. The possible reaction pathways comprise the S-N bond cleavage, ring-opening of isoxazole moiety, oxidation of aromatic amine, and the hydroxylation of the benzene ring; different OPs formed under acidic, neutral, and basic pH conditions are described. The value of k(app), 8.9 x 10(2) M-1 s(-1) at pH 7.0 suggests the oxidative transformation of SMX in seconds by 1 mg L-1 K2FeO4 and interestingly, the removal of SMX could be achieved at neutral pH by Fe(VI) in the presence of humic acid. (C) 2015 Elsevier B.V. All rights reserved. C1 [Kim, Chansik; Sharma, Virender K.] Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA. [Panditi, Venkata R.; Gardinali, Piero R.] Florida Int Univ, Dept Chem & Biochem, North Miami, FL 33181 USA. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Kim, Hyunook] Univ Seoul, Dept Environm Engn, Seoul 130743, South Korea. RP Kim, H (reprint author), Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, 212 Adriance Lab Rd,1266 TAMU, College Stn, TX 77843 USA. EM h_kim@uos.ac.kr; vsharma@sph.tamhsc.edu OI Sharma, Virender/0000-0002-5980-8675 FU United States National Science Foundation [CBET-1439314]; R&D program of MOTI/KEIT (RD program) [10037331] FX V.K. Sharma acknowledges the support of United States National Science Foundation (CBET-1439314) for the ferrate research. C. Kim and H. Kim acknowledge the support of the R&D program of MOTI/KEIT (R&D program number: 10037331, Development of Core Water Treatment Technologies based on Intelligent BT-NT-IT Fusion Platform). We also thank Dr. Sudha Rani for her help in analyzing the mass spectra data. NR 46 TC 12 Z9 14 U1 12 U2 69 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 1385-8947 EI 1873-3212 J9 CHEM ENG J JI Chem. Eng. J. PD NOV 1 PY 2015 VL 279 BP 307 EP 316 DI 10.1016/j.cej.2015.04.139 PG 10 WC Engineering, Environmental; Engineering, Chemical SC Engineering GA CP4SS UT WOS:000359873500035 ER PT J AU Sim, JY An, JY Elbeshbishy, E Ryu, HD Lee, HS AF Sim, Junyoung An, Junyeong Elbeshbishy, Elsayed Ryu, Hodon Lee, Hyung-Sool TI Characterization and optimization of cathodic conditions for H2O2 synthesis in microbial electrochemical cells SO BIORESOURCE TECHNOLOGY LA English DT Article DE Hydrogen peroxide; Cathode potential; Gas diffusion; Microbial electrochemical cell; Microbial fuel cell ID ANODE-RESPIRING BACTERIA; WASTE-WATER TREATMENT; FUEL-CELL; HYDROGEN-PEROXIDE; ELECTROLYSIS CELL; MEMBRANE AB Cathode potential and O-2 supply methods were investigated to improve H2O2 synthesis in an electrochemical cell, and optimal cathode conditions were applied for microbial electrochemical cells (MECs). Using aqueous O-2 for the cathode significantly improved current density, but H2O2 conversion efficiency was negligible at 0.3-12%. Current density decreased for passive O-2 diffusion to the cathode, but H2O2 conversion efficiency increased by 65%. An MEC equipped with a gas diffusion cathode was operated with acetate medium and domestic wastewater, which presented relatively high H2O2 conversion efficiency from 36% to 47%, although cathode overpotential was fluctuated. Due to different current densities, the maximum H2O2 production rate was 141 mg H2O2/L-h in the MEC fed with acetate medium, but it became low at 6 mg H2O2/L-h in the MEC fed with the wastewater. Our study clearly indicates that improving anodic current density and mitigating membrane fouling would be key parameters for large-scale H2O2-MECs. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Sim, Junyoung; An, Junyeong; Elbeshbishy, Elsayed; Lee, Hyung-Sool] Univ Waterloo, Dept Civil & Environm Engn, Waterloo, ON N2L 3G1, Canada. [Ryu, Hodon] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Lee, HS (reprint author), Univ Waterloo, Dept Civil & Environm Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. EM hyungsool@uwaterloo.ca FU Nautral Sciences and Engineering Research Council of Canada (NSERC) [402045-2011]; Ministry of Economic Development and Innovation FX This work was financially supported by Nautral Sciences and Engineering Research Council of Canada (NSERC) entitled "Development of energy-efficient wastewater treatment technology using principles of microbial fuel/electrolysis cells'' (NSERC DG #402045-2011) and Ministry of Economic Development and Innovation entitled "Development of sustainable anaerobic wastewater treatment technologies: recovery of value-added products''. NR 21 TC 3 Z9 3 U1 6 U2 61 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0960-8524 EI 1873-2976 J9 BIORESOURCE TECHNOL JI Bioresour. Technol. PD NOV PY 2015 VL 195 BP 31 EP 36 DI 10.1016/j.biortech.2015.06.076 PG 6 WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA CO8TL UT WOS:000359444600005 PM 26141667 ER PT J AU Fullerton, AH Torgersen, CE Lawler, JJ Faux, RN Steel, EA Beechie, TJ Ebersole, JL Leibowitz, SG AF Fullerton, Aimee H. Torgersen, Christian E. Lawler, Joshua J. Faux, Russell N. Steel, E. Ashley Beechie, Timothy J. Ebersole, Joseph L. Leibowitz, Scott G. TI Rethinking the longitudinal stream temperature paradigm: region-wide comparison of thermal infrared imagery reveals unexpected complexity of river temperatures SO HYDROLOGICAL PROCESSES LA English DT Article DE water temperature; remote sensing; longitudinal profile; spatial pattern ID WATER TEMPERATURE; CLIMATE-CHANGE; PACIFIC-NORTHWEST; HEADWATER STREAMS; UNITED-STATES; HABITAT; OREGON; DYNAMICS; SALMON; VARIABILITY AB Prevailing theory suggests that stream temperature warms asymptotically in a downstream direction, beginning at the temperature of the source in the headwaters and levelling off downstream as it converges to match meteorological conditions. However, there have been few empirical examples of longitudinal patterns of temperature in large rivers due to a paucity of data. We constructed longitudinal thermal profiles (temperature vs distance) for 53 rivers in the Pacific Northwest (USA) using an extensive data set of remotely sensed summertime river temperatures and classified each profile into one of five patterns of downstream warming: asymptotic (increasing then flattening), linear (increasing steadily), uniform (not changing), parabolic (increasing then decreasing), or complex (not fitting other classes). We evaluated (1) how frequently profiles warmed asymptotically downstream as expected, and (2) whether relationships between river temperature and common hydroclimatic variables differed by profile class. We found considerable diversity in profile shape, with 47% of rivers warming asymptotically and 53% having alternative profile shapes. Water temperature did not warm substantially over the course of the river for coastal parabolic and uniform profiles, and for some linear and complex profiles. Profile classes showed no clear geographical trends. The degree of correlation between river temperature and hydroclimatic variables differed among profile classes, but there was overlap among classes. Water temperature in rivers with asymptotic or parabolic profiles was positively correlated with August air temperature, tributary temperature and velocity, and negatively correlated with elevation, August precipitation, gradient and distance upstream. Conversely, associations were less apparent in rivers with linear, uniform or complex profiles. Factors contributing to the unique shape of parabolic profiles differed for coastal and inland rivers, where downstream cooling was influenced locally by climate or cool water inputs, respectively. Potential drivers of shape for complex profiles were specific to each river. These thermal patterns indicate diverse thermal habitats that may promote resilience of aquatic biota to climate change. Without this spatial context, climate change models may incorrectly estimate loss of thermally suitable habitat. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Fullerton, Aimee H.; Beechie, Timothy J.] NOAA, Fish Ecol Div, NW Fisheries Sci Ctr, Natl Marine Fisheries Serv, Seattle, WA 98112 USA. [Fullerton, Aimee H.; Lawler, Joshua J.] Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA. [Torgersen, Christian E.] Univ Washington, Forest & Rangeland Ecosyst Sci Ctr, Cascadia Field Stn, US Geol Survey, Seattle, WA 98195 USA. [Faux, Russell N.] Quantum Spatial Inc, Corvallis, OR USA. [Steel, E. Ashley] USDA Forest Serv, Pacific NW Res Stn, Seattle, WA USA. [Ebersole, Joseph L.; Leibowitz, Scott G.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR USA. RP Fullerton, AH (reprint author), NOAA, Fish Ecol Div, NW Fisheries Sci Ctr, Natl Marine Fisheries Serv, 2725 Montlake Blvd E, Seattle, WA 98112 USA. EM aimee.fullerton@noaa.gov FU Northwest Fisheries Science Center; NOAA Advanced Studies Program FX Individual river temperature surveys and image processing were conducted by R. Faux, Watershed Sciences Inc., except for rivers in the Salmon and Clearwater basins in Idaho, the data for which were provided by D. Essig of the Idaho Department of Environmental Quality. We are grateful to the many local, state, federal, tribal and nongovernmental organizations that funded the collection of these data for water quality monitoring and assessment. A.H.F. was supported by the Northwest Fisheries Science Center and the NOAA Advanced Studies Program. We thank P.M. Kiffney, N.J. Mantua, S.G. Smith and three anonymous reviewers for helpful discussions and reviews of earlier versions of the manuscript, and B.J. Burke for statistical advice. The information in this document has been subjected to peer and administrative review and is approved for publication by NOAA, USGS, EPA and USFS. Any use of trade, product or firm names is for descriptive purposes only and does not imply endorsement by the U.S. government. NR 78 TC 9 Z9 9 U1 7 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD OCT 30 PY 2015 VL 29 IS 22 BP 4719 EP 4737 DI 10.1002/hyp.10506 PG 19 WC Water Resources SC Water Resources GA CU1JN UT WOS:000363277400005 ER PT J AU Oczkowski, A McKinney, R Ayvazian, S Hanson, A Wigand, C Markham, E AF Oczkowski, Autumn McKinney, Richard Ayvazian, Suzanne Hanson, Alana Wigand, Cathleen Markham, Erin TI Preliminary Evidence for the Amplification of Global Warming in Shallow, Intertidal Estuarine Waters SO PLOS ONE LA English DT Article ID HUDSON RIVER ESTUARY; NARRAGANSETT BAY; FISH COMMUNITY; GROWTH-RATES; HEAT-WAVE; TEMPERATURE; OCEAN; ECOSYSTEM; NITROGEN; PHYTOPLANKTON AB Over the past 50 years, mean annual water temperature in northeastern U.S. estuaries has increased by approximately 1.2 degrees C, with most of the warming recorded in the winter and early spring. A recent survey and synthesis of data from four locations in Southern Rhode Island has led us to hypothesize that this warming may be amplified in the shallow (<1 m), nearshore portions of these estuaries. While intertidal areas are not typically selected as locations for long-term monitoring, we compiled data from published literature, theses, and reports that suggest that enhanced warming may be occurring, perhaps at rates three times higher than deeper estuarine waters. Warmer spring waters may be one of the factors influencing biota residing in intertidal regions both in general as well as at our specific sites. We observed greater abundance of fish, and size of Menidia sp., in recent (2010- 2012) seine surveys compared to similar collections in 1962. While any linkages are speculative and data are preliminary, taken together they suggest that shallow intertidal portions of estuaries may be important places to look for the effects of climate change. C1 [Oczkowski, Autumn; McKinney, Richard; Ayvazian, Suzanne; Hanson, Alana; Wigand, Cathleen] United States Environm Protect Agcy, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Markham, Erin] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. RP Oczkowski, A (reprint author), United States Environm Protect Agcy, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM Oczkowski.autumn@epa.gov FU U.S. Environmental Protection Agency FX The research described in this article has been funded by the U.S. Environmental Protection Agency, but has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 0 Z9 0 U1 1 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 28 PY 2015 VL 10 IS 10 AR e0141529 DI 10.1371/journal.pone.0141529 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CV0DL UT WOS:000363918100098 PM 26510009 ER PT J AU Lu, HF Fu, FY Li, H Campbell, DE Ren, H AF Lu, Hongfang Fu, Fangyan Li, Hao Campbell, Daniel E. Ren, Hai TI Eco-exergy and emergy based self-organization of three forest plantations in lower subtropical China SO SCIENTIFIC REPORTS LA English DT Article ID ECOSYSTEM SERVICES; WORLDS FORESTS; CLIMATE-CHANGE; INFORMATION; ORGANISMS; PRINCIPLE; SYSTEMS; CONSERVATION; BIODIVERSITY; INDICATORS AB The bio-thermodynamic structures of a mixed native species plantation, a conifer plantation and an Acacia mangium plantation in Southern China were quantified over a period of 15 years based on eco-exergy methods. The efficiencies of structural development and maintenance were quantified through an integrated application of eco-exergy and emergy methods. The results showed that the storage of eco-exergy increased over 3 times in all three plantations, as predicted by the maximum eco-exergy principle. This trend was primarily seen due to the accumulation of biomass, instead of an increase in the specific eco-exergy (eco-exergy per unit biomass), although species richness did increase. The eco-exergy to emergy and eco-exergy to empower ratios of the three plantations generally increased during the study period, but the rate of increase slowed down after 20 years. The dominant trees are the largest contributors to the eco-exergy stored in the plantations, and thus, the introduction of suitable indigenous tree species should be considered after the existing trees pass through their period of most rapid growth or around 20 years after planting. The combined application of C-values and suggested weighting factors in the eco-exergy calculation can imply opposite results, but may also supply useful information for forest management. C1 [Lu, Hongfang; Fu, Fangyan; Li, Hao; Ren, Hai] Chinese Acad Sci, Key Lab Vegetat Restorat & Management Degraded Ec, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA. RP Ren, H (reprint author), Chinese Acad Sci, Key Lab Vegetat Restorat & Management Degraded Ec, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. EM renhai@scbg.ac.cn FU National Natural Science Foundation of China [31170428]; Project of Science & Technology Plan of Guangdong Province [2013B060400016] FX This study is supported by Projects of the National Natural Science Foundation of China (31170428), and a Project of Science & Technology Plan of Guangdong Province (2013B060400016). NR 74 TC 0 Z9 0 U1 3 U2 20 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD OCT 21 PY 2015 VL 5 AR 15047 DI 10.1038/srep15047 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CU1LV UT WOS:000363284300001 PM 26486821 ER PT J AU Gilson, ER Huang, S van Groos, PGK Scheckel, KG Qafoku, O Peacock, AD Kaplan, DI Jaffe, PR AF Gilson, Emily R. Huang, Shan van Groos, Paul G. Koster Scheckel, Kirk G. Qafoku, Odeta Peacock, Aaron D. Kaplan, Daniel I. Jaffe, Peter R. TI Uranium Redistribution Due to Water Table Fluctuations in Sandy Wetland Mesocosms SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SAVANNA RIVER SITE; DRINKING-WATER; SEDIMENTS; IMMOBILIZATION; REOXIDATION; SPECIATION; REDUCTION; PLANT AB To understand better the fate and stability of immobilized uranium (U) in wetland sediments, and how intermittent dry periods affect U stability, we dosed saturated sandy wetland mesocosms planted with Scirpus acutus with low levels of uranyl acetate for 4 months before imposing a short drying and rewetting period. Concentrations of U in mesocosm effluent increased after drying and rewetting, but the cumulative amount of U released following the dry period constituted less than 1% of the total U immobilized in the soil during the 4 months prior. This low level of remobilization suggests, and XANES analyses confirm, that microbial reduction was not the primary means of U immobilization, as the U immobilized in mesocosms was primarily U(VI) rather than U(IV). Drying followed by rewetting caused a redistribution of U downward in the soil profile and to root surfaces. Although the U on roots before drying was primarily associated with minerals, the U that relocated to the roots during drying and rewetting was bound diffusely. Results show that short periods of drought conditions in a sandy wetland, which expose reduced sediments to air, may impact U distribution without causing large releases of soil-bound U to surface waters. C1 [Gilson, Emily R.; Huang, Shan; van Groos, Paul G. Koster; Jaffe, Peter R.] Princeton Univ, Princeton, NJ 08540 USA. [Scheckel, Kirk G.] US EPA, Cincinnati, OH 45268 USA. [Qafoku, Odeta] Pacific NW Natl Lab, Richland, WA 99352 USA. [Peacock, Aaron D.] Pace Analyt Energy Serv, Pittsburgh, PA 15238 USA. [Kaplan, Daniel I.] Savannah River Natl Lab, Aiken, SC 29808 USA. RP Jaffe, PR (reprint author), Princeton Univ, Dept Civil & Environm Engn, E Quad, Princeton, NJ 08540 USA. EM jaffe@princeton.edu RI ID, MRCAT/G-7586-2011; OI Scheckel, Kirk/0000-0001-9326-9241 FU Subsurface Biogeochemical Research Program of the U.S. Department of Energy's Office of Biological and Environmental Research [DE-SC0006847]; DOE Office of Science [DE-AC02-06CH11357]; DOE; MRCAT member institutions; EPA; Office of Biological and Environmental Research FX This research was supported through contract DE-SC0006847 by the Subsurface Biogeochemical Research Program of the U.S. Department of Energy's Office of Biological and Environmental Research. A portion of this research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. The Materials Research Collaborative Access Team (MRCAT) operations at the Advanced Photon Source are supported by the DOE and the MRCAT member institutions. Although the U.S. Environmental Protection Agency (EPA) contributed to some of the work described in this document, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this document are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. A portion of this research was performed using Radiochemistry Annex at EMSL, a DOE Office of Science User Facility sponsored by the Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory. NR 34 TC 2 Z9 2 U1 2 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 20 PY 2015 VL 49 IS 20 BP 12214 EP 12222 DI 10.1021/acs.est.5b02957 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CU2JB UT WOS:000363348700027 PM 26404564 ER PT J AU Corton, C AF Corton, C. TI Identification of potential endocrine disrupting chemicals using gene expression biomarkers SO TOXICOLOGY LETTERS LA English DT Meeting Abstract CT 51st Congress of the European-Societies-of-Toxicology (EUROTOX) CY SEP 13-16, 2015 CL Portuguese Soc Pharmacol, Sect Toxicol, Porto, PORTUGAL SP European Soc Toxicol HO Portuguese Soc Pharmacol, Sect Toxicol C1 [Corton, C.] US EPA, ISTD, NHEERL, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 16 PY 2015 VL 238 IS 2 SU S MA W03-3 BP S36 EP S36 DI 10.1016/j.toxlet.2015.08.098 PG 1 WC Toxicology SC Toxicology GA DE5SY UT WOS:000370693800099 ER PT J AU Krishan, M Rice, G AF Krishan, M. Rice, G. TI Chemical mixtures: Application of a tiered approach SO TOXICOLOGY LETTERS LA English DT Meeting Abstract CT 51st Congress of the European-Societies-of-Toxicology (EUROTOX) CY SEP 13-16, 2015 CL Portuguese Soc Pharmacol, Sect Toxicol, Porto, PORTUGAL SP European Soc Toxicol HO Portuguese Soc Pharmacol, Sect Toxicol C1 [Krishan, M.] ILSI North Amer, Washington, DC USA. [Rice, G.] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 16 PY 2015 VL 238 IS 2 SU S MA P17-003 BP S345 EP S345 DI 10.1016/j.toxlet.2015.08.986 PG 1 WC Toxicology SC Toxicology GA DE5SY UT WOS:000370693801820 ER PT J AU Lizarraga, LE Kaiser, JP Lambert, JC Wesselkamper, SC Zhao, QJ AF Lizarraga, L. E. Kaiser, J. P. Lambert, J. C. Wesselkamper, S. C. Zhao, Q. J. TI Alternative methods in human health risk assessment: Application of a tiered surrogate approach SO TOXICOLOGY LETTERS LA English DT Meeting Abstract CT 51st Congress of the European-Societies-of-Toxicology (EUROTOX) CY SEP 13-16, 2015 CL Portuguese Soc Pharmacol, Sect Toxicol, Porto, PORTUGAL SP European Soc Toxicol HO Portuguese Soc Pharmacol, Sect Toxicol C1 [Lizarraga, L. E.] Oak Ridge Associated Univ, Oak Ridge Inst Sci & Educ, Cincinnati, OH USA. [Kaiser, J. P.; Lambert, J. C.; Wesselkamper, S. C.; Zhao, Q. J.] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 16 PY 2015 VL 238 IS 2 SU S MA P03-022 BP S94 EP S95 DI 10.1016/j.toxlet.2015.08.314 PG 2 WC Toxicology SC Toxicology GA DE5SY UT WOS:000370693801151 ER PT J AU Price, P AF Price, P. TI Value and challenges of screening level assessments of co-exposures SO TOXICOLOGY LETTERS LA English DT Meeting Abstract CT 51st Congress of the European-Societies-of-Toxicology (EUROTOX) CY SEP 13-16, 2015 CL Portuguese Soc Pharmacol, Sect Toxicol, Porto, PORTUGAL SP European Soc Toxicol HO Portuguese Soc Pharmacol, Sect Toxicol C1 [Price, P.] US EPA, Computat Exposure Scientist Natl Exposure Res Lab, Stamford, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 16 PY 2015 VL 238 IS 2 SU S MA CEC5-3 BP S9 EP S9 DI 10.1016/j.toxlet.2015.08.061 PG 1 WC Toxicology SC Toxicology GA DE5SY UT WOS:000370693800026 ER PT J AU Murphy, BN Julin, J Riipinen, I Ekman, AML AF Murphy, B. N. Julin, J. Riipinen, I. Ekman, A. M. L. TI Organic aerosol processing in tropical deep convective clouds: Development of a new model (CRM-ORG) and implications for sources of particle number SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article AB The difficulty in assessing interactions between atmospheric particles and clouds is due in part to the chemical complexity of the particles and to the wide range of length and timescales of processes occurring simultaneously during a cloud event. The new Cloud-Resolving Model with Organics (CRM-ORG) addresses these interactions by explicitly predicting the formation, transport, uptake, and re-release of surrogate organic compounds consistent with the volatility basis set framework within a nonhydrostatic, three-dimensional cloud-resolving model. CRM-ORG incorporates photochemical production, explicit condensation/evaporation of organic and inorganic vapors, and a comprehensive set of four different mechanisms describing particle formation from organic vapors and sulfuric acid. We simulate two deep convective cloud events over the Amazon rain forest in March 1998 and compare modeled particle size distributions with airborne observations made during the time period. The model predictions agree well with the observations for Aitken mode particles in the convective outflow (10-14 km) but underpredict nucleation mode particles by a factor of 20. A strong in-cloud particle formation process from organic vapors alone is necessary to reproduce even relatively low ultrafine particle number concentrations (similar to 1500 cm(-3)). Sensitivity tests with variable initial aerosol loading and initial vertical aerosol profile demonstrate the complexity of particle redistribution and net gain or loss in the cloud. In-cloud particle number concentrations could be enhanced by as much as a factor of 3 over the base case simulation in the cloud outflow but were never reduced by more than a factor of 2 lower than the base. Additional sensitivity cases emphasize the need for constrained estimates of surface tension and affinity of organic vapors to ice surfaces. When temperature-dependent organic surface tension is introduced to the new particle formation mechanisms, the number concentration of particles decreases by 60% in the cloud outflow. These uncertainties are discussed in light of the other prominent challenges for understanding the interactions between organic aerosols and clouds. Recommendations for future theoretical, laboratory, and field work are proposed. C1 [Murphy, B. N.; Ekman, A. M. L.] Stockholm Univ, Dept Meteorol, Stockholm, Sweden. [Murphy, B. N.; Julin, J.; Riipinen, I.] Stockholm Univ, Dept Environm Sci & Analyt Chem, Stockholm, Sweden. [Murphy, B. N.; Julin, J.; Riipinen, I.; Ekman, A. M. L.] Bolin Ctr Climate Res, Stockholm, Sweden. RP Murphy, BN (reprint author), US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. EM annica@misu.su.se RI Julin, Jan/P-6931-2015 OI Julin, Jan/0000-0002-4845-1631 FU Marie Curie People program; European Research Council (ERC) [278277 ATMOGAIN]; Vetenskapsradet [2011-5120] FX This work was funded by the Marie Curie People program, the European Research Council (ERC starting grant 278277 ATMOGAIN) and Vetenskapsradet (grant 2011-5120). CloudSat data were obtained through the CloudSat Data Processing Center (http://www.cloudsat.cira.colostate.edu/). CALIPSO data were obtained through the Atmospheric Sciences Data Center (ASDC) at the NASA Langley Research Center (http://eosweb.larc.nasa.gov/). The CRM-ORG source code and scripts to run the model are freely available by contacting A. M. L. Ekman or I. Riipinen. The data output used to generate the plots for this manuscript are stored on the supercomputing system managed by the Swedish National Supercomputing Center (NSC) in Linkoping, Sweden, and available upon request (annica@misu.su.se or ilona.riipinen@aces.su.se). NR 82 TC 1 Z9 1 U1 9 U2 23 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD OCT 16 PY 2015 VL 120 IS 19 BP 10441 EP 10464 DI 10.1002/2015JD023551 PG 24 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA V45WR UT WOS:000209847200036 ER PT J AU White, AJ Nichols, HB Bradshaw, PT Sandler, DP AF White, Alexandra J. Nichols, Hazel B. Bradshaw, Patrick T. Sandler, Dale P. TI Overall and Central Adiposity and Breast Cancer Risk in the Sister Study SO CANCER LA English DT Article DE adiposity; body mass index; breast neoplasms; waist circumference ID HORMONE-RECEPTOR STATUS; BODY-MASS INDEX; WAIST CIRCUMFERENCE; UNITED-STATES; OBESITY; WOMEN; SIZE; PREMENOPAUSAL; ESTROGEN; HEALTH AB BACKGROUND: Greater body mass index (BMI), a measure of overall adiposity, is associated with a higher risk of postmenopausal breast cancer. The role of central adiposity, often measured by waist circumference, is less well understood, especially among premenopausal women. The objective of the current study was to examine multiple measures of adiposity in relation to breast cancer in a prospective cohort study. METHODS: A total of 50,884 Sister Study cohort participants aged 35 to 74 years were enrolled from 2003 through 2009. Inclusion criteria for the cohort included having a sister previously diagnosed with breast cancer. Trained study personnel measured height, weight, and waist and hip circumference during a home visit and study participants completed a detailed questionnaire. Using Cox regression analysis, we estimated multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) for breast cancer risk associated with adiposity measurements, considering tumor subtype and menopausal status. RESULTS: In total, 2009 breast cancers were diagnosed during follow-up (mean=5.4 years). Weight, BMI, waist circumference, and waist-to-hip ratio were found to be positively associated with overall breast cancer risk and HRs were greater among postmenopausal women, those with hormonally responsive tumors, and women who were not currently using postmenopausal hormones. In models that adjusted for BMI, waist circumference associations persisted among both postmenopausal women (81-88 cm vs <= 80 cm: HR=1.16 [95% CI 1.01-1.35] and > 88 cm vs <= 80 cm: HR=1.30 [95% CI 1.10-1.54]) and premenopausal women (81-88 cm vs <= 80 cm: HR=1.56 [95% CI 1.19-2.04] and > 88 cm vs <= 80 cm: HR=1.30 [95% CI 0.91-1.87]). CONCLUSIONS: Findings from this large, prospective study with examiner-measured body size indicate that waist circumference is independently and positively associated with both premenopausal and postmenopausal breast cancer risk. (c) 2015 American Cancer Society. C1 [White, Alexandra J.; Nichols, Hazel B.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Bradshaw, Patrick T.] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA. [Sandler, Dale P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA. RP Nichols, HB (reprint author), Univ N Carolina, Dept Epidemiol, 2102A McGavran Greenberg Hall,135 Dauer Dr, Chapel Hill, NC 27599 USA. EM hazel.nichols@unc.edu OI Sandler, Dale/0000-0002-6776-0018 FU Intramural Research Program of the National Institutes of Health; National Institute of Environmental Health Sciences [Z01-ES044005]; Avon Foundation [02-2012-085]; National Center for Advancing Translational Sciences [KL2-TR001109]; UNC Lineberger Cancer Control Education Program [R25 CA57726] FX Supported in part by the Intramural Research Program of the National Institutes of Health, the National Institute of Environmental Health Sciences (Z01-ES044005), the Avon Foundation (02-2012-085), the National Center for Advancing Translational Sciences (KL2-TR001109), and the UNC Lineberger Cancer Control Education Program (R25 CA57726). NR 35 TC 8 Z9 8 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD OCT 15 PY 2015 VL 121 IS 20 BP 3700 EP 3708 DI 10.1002/cncr.29552 PG 9 WC Oncology SC Oncology GA CU1EN UT WOS:000363262700019 PM 26193782 ER PT J AU Kim, YH Wyrzykowska-Ceradini, B Touati, A Krantz, QT Dye, JA Linak, WP Gullett, B Gilmour, MI AF Kim, Yong Ho Wyrzykowska-Ceradini, Barbara Touati, Abderrahmane Krantz, Q. Todd Dye, Janice A. Linak, William P. Gullett, Brian Gilmour, M. Ian TI Characterization of Size-Fractionated Airborne Particles Inside an Electronic Waste Recycling Facility and Acute Toxicity Testing in Mice SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; CUT LUNG SLICES; IN-VITRO; INTRATRACHEAL INSTILLATION; OXIDATIVE STRESS; HOUSE-DUST; INDOOR AIR; EXPOSURE; METALS AB Disposal of electronic waste (e-waste) in landfills, incinerators, or at rudimentary recycling sites can lead to the release of toxic chemicals into the environment and increased health risks. Developing e-waste recycling technologies at commercial facilities can reduce the release of toxic chemicals and efficiently recover valuable materials. While these e-waste operations represent a vast improvement over previous approaches, little is known about environmental releases, workplace exposures, and potential health impacts. In this study, airborne particulate matter (PM) was measured at various locations within a modern U.S.-based e-waste recycling facility that utilized mechanical processing. In addition, composite size fractionated PM (coarse, fine and ultrafine) samples were collected, extracted, chemically analyzed, and given by oropharyngeal aspiration to mice or cultured with lung slices for lung toxicity tests. Indoor total PM concentrations measured during the study ranged from 220 to 1200 mu g/m(3). In general, the coarse PM (2.5-10 mu m) was 3-4 times more abundant than fine/ultrafine PM (<2.5 mu m). The coarse PM contained higher levels of Ni, Pb, and Zn (up to 6.8 times) compared to the fine (0.1-2.5 mu m) and ultrafine (<0.1 mu m) PM. Compared to coarse PM measurements from a regional near-roadway study, Pb and Ni were enriched 170 and 20 times, respectively, in the indoor PM, with other significant enrichments (>10 times) observed for Zn and Sb, modest enrichments (>5 times) for Cu and Sr, and minor enrichments (>2 times) for Cr, Cd, Mn, Ca, Fe, and Ba. Negligible enrichment (<2 times) or depletion (<1 time) were observed for Al, Mg, Ti, Si, and V. The coarse PM fraction elicited significant pro-inflammatory responses in the mouse lung at 24 h postexposure compared to the fine and ultrafine PM, and similar toxicity outcomes were observed in the lung slice model. We conclude that exposure to coarse PM from the facility caused substantial inflammation in the mouse lung and enrichment of these metals compared to levels normally present in the ambient PM could be of potential health concern. C1 [Kim, Yong Ho; Krantz, Q. Todd; Dye, Janice A.; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Linak, William P.; Gullett, Brian] US EPA, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. [Wyrzykowska-Ceradini, Barbara; Touati, Abderrahmane] ARCADIS US Inc, Durham, NC 27713 USA. [Kim, Yong Ho] CNR, Washington, DC 20001 USA. RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM gilmour.ian@epa.gov FU National Research Council Senior Research Associateship Award at the U.S. Environmental Protection Agency FX We thank Elizabeth Boykin, Debora Andrews, Judy Richards, and Richard Jaskot for technical assistance in toxicologic analyses; John McGee for technical assistance in PM chemical analyses; and Drs. Aimen Farraj and James Samet for their review of this manuscript. This study was performed while Dr. Yong Ho Kim held a National Research Council Senior Research Associateship Award at the U.S. Environmental Protection Agency. This paper has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that contents necessarily reflect the views and polices of the EPA, nor does the mention of trade names or commercial products constitute endorsement or recommendation for use. NR 48 TC 2 Z9 2 U1 11 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 6 PY 2015 VL 49 IS 19 BP 11543 EP 11550 DI 10.1021/acs.est.5b03263 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CT2JZ UT WOS:000362629100034 PM 26332991 ER PT J AU Strynar, M Dagnino, S McMahen, R Liang, S Lindstrom, A Andersen, E McMillan, L Thurman, M Ferrer, I Ball, C AF Strynar, Mark Dagnino, Sonia McMahen, Rebecca Liang, Shuang Lindstrom, Andrew Andersen, Erik McMillan, Larry Thurman, Michael Ferrer, Imma Ball, Carol TI Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERFLUORINATED COMPOUNDS; PERFLUOROOCTANOIC ACID; SUBSTANCES PFASS; STATEMENT; BASIN AB Recent scientific scrutiny and concerns over exposure, toxicity, and risk have led to international regulatory efforts resulting in the reduction or elimination of certain perfluorinated compounds from various products and waste streams. Some manufacturers have started producing shorter chain per- and polyfluorinated compounds to try to reduce the potential for bioaccumulation in humans and wildlife. Some of these new compounds contain central ether oxygens or other minor modifications of traditional perfluorinated structures. At present, there has been very limited information published on these "replacement chemistries" in the peer-reviewed literature. In this study we used a time-of-flight mass spectrometry detector (LC-ESI-TOFMS) to identify fluorinated compounds in natural waters collected from locations with historical perfluorinated compound contamination. Our workflow for discovery of chemicals included sequential sampling of surface water for identification of potential sources, nontargeted TOFMS analysis, molecular feature extraction (MFE) of samples, and evaluation of features unique to the sample with source inputs. Specifically, compounds were tentatively identified by (I) accurate mass determination of parent and/or related adducts and fragments from in-source collision-induced dissociation (CID), (2) in-depth evaluation of in-source adducts formed during analysis, and (3) confirmation with authentic standards when available. We observed groups of compounds in homologous series that differed by multiples of CF2 (m/z 49.9968) or CF2O (m/z 65. 9917). Compounds in each series were chromatographically separated and had comparable fragments and adducts produced during analysis. We detected 12 novel perfluoroalkyl ether carboxylic and sulfonic acids in surface water in North Carolina,USA using this approach. A key piece of evidence was the discovery of accurate mass in-source n-mer formation (H+ and Na+) differing by m/z 21.9819, corresponding to the mass difference between the protonated and sodiated dimers. C1 [Strynar, Mark; Dagnino, Sonia; McMahen, Rebecca; Liang, Shuang; Lindstrom, Andrew; Andersen, Erik] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Dagnino, Sonia; McMahen, Rebecca; Liang, Shuang] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [McMillan, Larry] Natl Caucus & Ctr Black Aged Inc, Durham, NC 27713 USA. [Thurman, Michael; Ferrer, Imma] Univ Colorado, Ctr Environm Mass Spectrometry, Boulder, CO 80309 USA. [Ball, Carol] Agilent Technol, Wilmington, DE 19808 USA. RP Strynar, M (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM strynar.mark@epa.gov RI Ferrer, Imma/A-8161-2008 OI Ferrer, Imma/0000-0002-8730-7851 FU United States Environmental Protection Agency through Office of Research and Development FX We thank Agilent Technologies for their support of this effort through a TOFMS and travel/training CRADA with the U.S. EPA (CRADA 437-A-12) and in particular Joe Weitzel for his support of this work. In addition, we thank Mike Hays (USEPA), and Chris Higgins and Simon Roberts (Colorado School of Mines) for the use of their QTOFs in confirmation of select compounds identified. We also thank John Offenberg, Michelle Angrish, and Mike Hays for their review of this manuscript. The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 25 TC 12 Z9 12 U1 9 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 6 PY 2015 VL 49 IS 19 BP 11622 EP 11630 DI 10.1021/acs.est.5b01215 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CT2JZ UT WOS:000362629100043 PM 26392038 ER PT J AU Smith, RL Ruiz-Mercado, GJ Gonzalez, MA AF Smith, Raymond L. Ruiz-Mercado, Gerardo J. Gonzalez, Michael A. TI Using GREENSCOPE indicators for sustainable computer-aided process evaluation and design SO COMPUTERS & CHEMICAL ENGINEERING LA English DT Article; Proceedings Paper CT 8th International Conference on the Foundations-of-Computer-Aided-Process-Design (FOCAPD) CY JUL 13-17, 2014 CL Cle Elum, WA SP US Natl Sci Fdn, AIChE Sustainable Engn Forum, AspenTech, Auburn Univ, Samuel Ginn Coll Engn, Bryan Res & Engn, Eastman Chem Co, Evonik Ind, Honeywell UOP, SimSci Schneider Elect, Fdn Comp Aided Proc Design DE Chemical; Process; Sustainability; Optimization; GREENSCOPE ID CHEMICAL-PROCESSES AB Manufacturing sustainability can be increased by educating those who design, construct, and operate facilities, and by using appropriate tools for process evaluation and design. The U.S. Environmental Protection Agency's GREENSCOPE methodology and tool, for evaluation and design of chemical processes, suits these purposes. This work describes example calculations of GREENSCOPE indicators for the oxidation of toluene and puts them into context with best- and worst-case limits. Data available from the process is transformed by GREENSCOPE into understandable information which describes sustainability. An optimization is performed for various process conversions, with results indicating a maximum utility at intermediate conversions. Lower conversions release too much toluene through a purge stream; higher conversions lead to the formation of too many byproducts. Detailed results are elucidated through the context of best- and worst-case limits and graphs of total utility and GREENSCOPE indicator values, which are calculated within an optimization framework for the first time. Published by Elsevier Ltd. C1 [Smith, Raymond L.; Ruiz-Mercado, Gerardo J.; Gonzalez, Michael A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Smith, RL (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM smith.raymond@epa.gov NR 29 TC 3 Z9 3 U1 4 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0098-1354 EI 1873-4375 J9 COMPUT CHEM ENG JI Comput. Chem. Eng. PD OCT 4 PY 2015 VL 81 SI SI BP 272 EP 277 DI 10.1016/j.compchemeng.2015.04.020 PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Chemical SC Computer Science; Engineering GA CQ0GY UT WOS:000360274600022 ER PT J AU Stiegel, MA Pleil, JD Sobus, JR Angrish, MM Morgan, MK AF Stiegel, M. A. Pleil, J. D. Sobus, J. R. Angrish, M. M. Morgan, M. K. TI Kidney injury biomarkers and urinary creatinine variability in nominally healthy adults SO BIOMARKERS LA English DT Article DE Computational biology; environmental pollution; ecotoxicology; growth factors; cytokines; inflammatory mediators; immunotoxicity; metabol(n)omics ID ENDOTHELIAL GROWTH-FACTOR; RISK-ASSESSMENT; TUBULAR INJURY; BIOMONITORING DATA; BREATH BIOMARKERS; CHEMICAL-EXPOSURE; SYSTEMS BIOLOGY; HUMAN EXPOSOME; RENAL INJURY; CANCER AB Environmental exposure diagnostics use creatinine concentrations in urine aliquots as the internal standard for dilution normalization of all other excreted metabolites when urinary excretion rate data are not available. This is a reasonable approach for healthy adults as creatinine is a human metabolite that is continually produced in skeletal muscles and presumably excreted in the urine at a stable rate. However, creatinine also serves as a biomarker for glomerular filtration rate (efficiency) of the kidneys, so undiagnosed kidney function impairment could affect this commonly applied dilution calculation. The United States Environmental Protection Agency (US EPA) has recently conducted a study that collected approximately 2600 urine samples from 50 healthy adults, aged 19-50 years old, in North Carolina in 2009-2011. Urinary ancillary data (creatinine concentration, total void volume, elapsed time between voids), and participant demographic data (race, gender, height, and body weight) were collected. A representative subset of 280 urine samples from 29 participants was assayed using a new kidney injury panel (KIP). In this article, we investigated the relationships of KIP biomarkers within and between subjects and also calculated their interactions with measured creatinine levels. The aims of this work were to document the analytical methods (procedures, sensitivity, stability, etc.), provide summary statistics for the KIP biomarkers in healthy adults without diagnosed disease (distribution, fold range, central tendency, variance), and to develop an understanding as to how urinary creatinine level varies with respect to the individual KIP proteins. Results show that new instrumentation and data reduction methods have sufficient sensitivity to measure KIP levels in nominally healthy urine samples, that linear regression between creatinine concentration and urinary excretion explains only about 68% of variability, that KIP markers are poorly correlated with creatinine (r(2) approximate to 0.34), and that statistical outliers of KIP markers are not random, but are clustered within certain subjects. In addition, we interpret these new adverse outcome pathways based in vivo biomarkers for their potential use as intermediary chemicals that may be diagnostic of kidney adverse outcomes to environmental exposure. C1 [Stiegel, M. A.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Publ Hlth, Chapel Hill, NC USA. [Stiegel, M. A.; Angrish, M. M.] US EPA, ORISE, Res Triangle Pk, NC 27711 USA. [Pleil, J. D.; Sobus, J. R.; Morgan, M. K.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Pleil, JD (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM pleil.joachim@epa.gov NR 76 TC 1 Z9 1 U1 2 U2 6 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1354-750X EI 1366-5804 J9 BIOMARKERS JI Biomarkers PD OCT 3 PY 2015 VL 20 IS 6-7 BP 436 EP 452 DI 10.3109/1354750X.2015.1094136 PG 17 WC Biotechnology & Applied Microbiology; Toxicology SC Biotechnology & Applied Microbiology; Toxicology GA CX4EM UT WOS:000365651700012 PM 26616147 ER PT J AU Chiang, LC Yuan, YP AF Chiang, Li-Chi Yuan, Yongping TI The NHDPlus dataset, watershed subdivision and SWAT model performance SO HYDROLOGICAL SCIENCES JOURNAL-JOURNAL DES SCIENCES HYDROLOGIQUES LA English DT Article DE SWAT simulation; NHDPlus; watershed subdivision; HRU definition; runoff; sediment; total nitrogen ID CALIBRATION; SIMULATION; SEDIMENT; SENSITIVITY; VALIDATION; MULTISITE; SCENARIOS; IMPACTS; BASIN; TEXAS AB The Soil and Water Assessment Tool (SWAT) has been developed to evaluate the effectiveness of agricultural management practices on watershed water quality. Many studies have indicated that watershed subdivision can affect the accuracy of model predictions. Most of them used the minimum drainage area (MDA) to delineate sub-watersheds, and varied the value of MDA depending on the size of the watershed being modelled. Instead of MDA, we use the National Hydrography Dataset Plus (NHDPlus)-an integration of the best features of the National Hydrography Dataset (NHD), Watershed Boundary Dataset (WBD), National Elevation Dataset (NED), and the National Land Cover Dataset (NLCD)-to delineate the watershed. The Kaskaskia River watershed in Illinois, USA, was selected to investigate the individual effects of sub-watershed and hydrologic response unit (HRU) delineations on predicted streamflow, total suspended sediment (TSS) and total nitrogen (TN) losses at two USGS gauges. In addition, an MDA of 3000 ha, and four levels of stream (the 2nd, 3rd, 4th and 5th order) were evaluated. Three levels of HRU threshold (5%, 10% and 15%) were used for each stream order model. The results show that stream order had little effect on predicted streamflow, but a great impact on TSS and TN losses, and the impact of HRU delineation became greater when a higher stream order was used to delineate the watershed. For higher stream order, fewer streams were recognized in SWAT simulations, which resulted in less sediment routing and channel processes, which, in turn, led to less deposition in the channels; thus high sediment losses were obtained at the watershed outlet. However, fewer channel processes led to less in-stream N processes; thus lower TN losses. Overall, the SWAT simulations performed the best when the 2nd stream order was used for delineations comparing with USGS observed data, followed by the 3rd stream order. Therefore, to fully depict the watershed characteristics to perform SWAT simulations, a stream order higher than 3rd order is not recommended for watershed delineation. C1 [Chiang, Li-Chi] Natl United Univ, Dept Civil & Disaster Prevent Engn, Miaoli 36003, Taiwan. [Yuan, Yongping] US EPA, Off Res & Dev, NERL ESD Landscape Ecol Branch, Las Vegas, NV 89193 USA. RP Chiang, LC (reprint author), Natl United Univ, Dept Civil & Disaster Prevent Engn, Miaoli 36003, Taiwan. EM yuan.yongping@epa.gov FU United States Environmental Protection Agency (USEPA) through its Office of Research and Development FX The United States Environmental Protection Agency (USEPA) through its Office of Research and Development funded and managed the research described here. NR 27 TC 0 Z9 0 U1 4 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0262-6667 EI 2150-3435 J9 HYDROLOG SCI J JI Hydrol. Sci. J.-J. Sci. Hydrol. PD OCT 3 PY 2015 VL 60 IS 10 BP 1690 EP 1708 DI 10.1080/02626667.2014.916408 PG 19 WC Water Resources SC Water Resources GA CV8TB UT WOS:000364559500003 ER PT J AU Chen, HY Tong, STY Yang, H Yang, YJ AF Chen, Heyin Tong, Susanna T. Y. Yang, Heng Yang, Y. Jeffrey TI Simulating the hydrologic impacts of land-cover and climate changes in a semi-arid watershed SO HYDROLOGICAL SCIENCES JOURNAL-JOURNAL DES SCIENCES HYDROLOGIQUES LA English DT Article DE land-cover change; climate change adaptation; hydrologic impacts; cell-based modeling ID COLORADO RIVER-BASIN; UNITED-STATES; RESOURCES; MODEL; RAINFALL; RUNOFF; ELEVATION; SWAT AB Changes in climate and land cover are among the principal variables affecting watershed hydrology. This paper uses a cell-based model to examine the hydrologic impacts of climate and land-cover changes in the semi-arid Lower Virgin River (LVR) watershed located upstream of Lake Mead, Nevada, USA. The cell-based model is developed by considering direct runoff based on the Soil Conservation Service - Curve Number (SCS-CN) method and surplus runoff based on the Thornthwaite water balance theory. After calibration and validation, the model is used to predict LVR discharge under future climate and land-cover changes. The hydrologic simulation results reveal climate change as the dominant factor and land-cover change as a secondary factor in regulating future river discharge. The combined effects of climate and land-cover changes will slightly increase river discharge in summer but substantially decrease discharge in winter. This impact on water resources deserves attention in climate change adaptation planning. C1 [Chen, Heyin; Tong, Susanna T. Y.; Yang, Heng] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Chen, HY (reprint author), Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA. EM susanna.tong@uc.edu FU US Environmental Protection Agency through its Office of Research and Development [EP-C-11-006]; Department of Geography at the University of Cincinnati FX This research was partially funded by the US Environmental Protection Agency through its Office of Research and Development [grant number EP-C-11-006] and the Department of Geography at the University of Cincinnati. The authors are grateful to the agency for the financial support. NR 56 TC 0 Z9 0 U1 2 U2 29 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0262-6667 EI 2150-3435 J9 HYDROLOG SCI J JI Hydrol. Sci. J.-J. Sci. Hydrol. PD OCT 3 PY 2015 VL 60 IS 10 BP 1739 EP 1758 DI 10.1080/02626667.2014.948445 PG 20 WC Water Resources SC Water Resources GA CV8TB UT WOS:000364559500006 ER PT J AU Fletcher, TD Shuster, W Hunt, WF Ashley, R Butler, D Arthur, S Trowsdale, S Barraud, S Semadeni-Davies, A Bertrand-Krajewski, JL Mikkelsen, PS Rivard, G Uhl, M Dagenais, D Viklander, M AF Fletcher, Tim D. Shuster, William Hunt, William F. Ashley, Richard Butler, David Arthur, Scott Trowsdale, Sam Barraud, Sylvie Semadeni-Davies, Annette Bertrand-Krajewski, Jean-Luc Mikkelsen, Peter Steen Rivard, Gilles Uhl, Mathias Dagenais, Danielle Viklander, Maria TI SUDS, LID, BMPs, WSUD and more - The evolution and application of terminology surrounding urban drainage SO URBAN WATER JOURNAL LA English DT Review DE urban stormwater management; water sensitive urban design (WSUD); stormwater control measures (SCMs); terminology; Joint Committee on Urban Drainage (JCUD); alternative techniques; low impact development (LID); low impact urban design and development (LIUDD); urban drainage; integrated urban water management (IUWM); sustainable urban drainage systems (SUDS); best management practices (BMPs); green infrastructure (GI); source control ID INTEGRATED WATER MANAGEMENT; DESIGN; INFRASTRUCTURE; REMOVAL; CITIES AB The management of urban stormwater has become increasingly complex over recent decades. Consequently, terminology describing the principles and practices of urban drainage has become increasingly diverse, increasing the potential for confusion and miscommunication. This paper documents the history, scope, application and underlying principles of terms used in urban drainage and provides recommendations for clear communication of these principles. Terminology evolves locally and thus has an important role in establishing awareness and credibility of new approaches and contains nuanced understandings of the principles that are applied locally to address specific problems. Despite the understandable desire to have a 'uniform set of terminology', such a concept is flawed, ignoring the fact that terms reflect locally shared understanding. The local development of terminology thus has an important role in advancing the profession, but authors should facilitate communication between disciplines and between regions of the world, by being explicit and accurate in their application. C1 [Fletcher, Tim D.] Univ Melbourne, Waterway Ecosyst Res Grp, Dept Resource Mgt & Geog, Melbourne, Vic 3010, Australia. [Shuster, William] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Hunt, William F.] N Carolina State Univ, Dept Biol & Agr Engn, Raleigh, NC 27695 USA. [Ashley, Richard] Univ Sheffield, Pennine Water Grp, Sheffield, S Yorkshire, England. [Ashley, Richard] Univ Sheffield, Dept Civil & Struct Engn, Sheffield, S Yorkshire, England. [Butler, David] Univ Exeter, Coll Engn Math & Phys Sci, Ctr Water Syst, Exeter EX4 4QJ, Devon, England. [Arthur, Scott] Heriot Watt Univ, Inst Infrastruct & Environm, Edinburgh, Midlothian, Scotland. [Trowsdale, Sam] Univ Auckland, Sch Environm, Auckland 1, New Zealand. [Barraud, Sylvie; Bertrand-Krajewski, Jean-Luc] Univ Lyon, INSA Lyon, LGCIE, F-69621 Villeurbanne, France. [Semadeni-Davies, Annette] Natl Inst Water & Atmospher Res, NIWA, Auckland, New Zealand. [Mikkelsen, Peter Steen] Tech Univ Denmark, Dept Environm Engn DTU Environm, DK-2800 Lyngby, Denmark. [Rivard, Gilles] Genivar Inc, Laval, PQ, Canada. [Uhl, Mathias] Muenster Univ Appl Sci, Fac Civil Engn, Inst Water Resources Environm IWARU, Munster, Germany. [Dagenais, Danielle] Univ Montreal, Sch Landscape Architecture, Fac Environm Design, Montreal, PQ, Canada. [Viklander, Maria] Lulea Univ Technol, Dept Civil Environm & Min Engn, S-95187 Lulea, Sweden. RP Fletcher, TD (reprint author), Univ Melbourne, Waterway Ecosyst Res Grp, Dept Resource Mgt & Geog, Melbourne, Vic 3010, Australia. EM tim.fletcher@unimelb.edu.au RI Mikkelsen, Peter/D-9691-2011; OI Mikkelsen, Peter/0000-0003-3799-0493; Arthur, Scott/0000-0002-9477-911X; Bertrand-Krajewski, Jean-Luc/0000-0003-3204-8861 NR 149 TC 52 Z9 54 U1 38 U2 153 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1573-062X EI 1744-9006 J9 URBAN WATER J JI Urban Water J. PD OCT 3 PY 2015 VL 12 IS 7 BP 525 EP 542 DI 10.1080/1573062X.2014.916314 PG 18 WC Water Resources SC Water Resources GA CQ1PT UT WOS:000360371100002 ER PT J AU Suter, GW Cormier, SM AF Suter, Glenn W., II Cormier, Susan M. TI The Problem of Biased Data and Potential Solutions for Health and Environmental Assessments SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE research bias; data; risk assessment; research fraud; peer review; data quality ID CONFLICT-OF-INTEREST; GOOD LABORATORY PRACTICES; EMPIRICAL-EVIDENCE; METHODOLOGICAL QUALITY; SAFETY ASSESSMENTS; REGULATORY SCIENCE; RESEARCH INTEGRITY; CONTROLLED-TRIALS; POLICY; MEDICINE AB The utility and credibility of environmental assessments depend on the use of unbiased data. However, it is increasingly clear that, despite peer review, much of the scientific literature is biased. Sources of bias include publication practices, research design and implementation, funding influences, investigator expectations, statistical methods, confounding, suppression, and fraud. Assessors can take precautions against biased data by performing their own reviews of the sources of data, checking for retractions and corrections, requiring full disclosure of methods, acquiring original data and reanalyzing it, avoiding secondary sources, avoiding unreplicated studies or studies that are not concordant with related studies, and checking for funding or investigator biases. Journals, government agencies, and other institutions can take many more types of actions to reduce bias in scientific data. Some of these are already being implemented but others will require a greater willingness to enforce scientific ethical standards. C1 [Suter, Glenn W., II; Cormier, Susan M.] US EPA, Cincinnati, OH 45268 USA. RP Suter, GW (reprint author), US EPA, 26 W Martin L King Dr, Cincinnati, OH 45268 USA. EM Suter.glenn@epa.gov NR 110 TC 4 Z9 4 U1 4 U2 40 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD OCT 3 PY 2015 VL 21 IS 7 BP 1736 EP 1752 DI 10.1080/10807039.2014.974499 PG 17 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CK8PI UT WOS:000356500000002 ER PT J AU Segal, D Lin, YS Ginsberg, G Sonawane, B AF Segal, Deborah Lin, Yu-Sheng Ginsberg, Gary Sonawane, Babasaheb TI A Conceptual Framework for Evaluating the Interaction of a Chemical and Nonchemical Stressor in Human Health Risk Assessments: A Case Study for Lead and Psychosocial Stress SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE cumulative risk assessment; nonchemical stressor interactions; lead neurodevelopmental toxicity; psychosocial stress ID PORT-PIRIE COHORT; INTERNATIONAL POOLED ANALYSIS; ANTENATAL MATERNAL ANXIETY; LONG-TERM POTENTIATION; PRENATAL STRESS; SOCIOECONOMIC-STATUS; ENVIRONMENTAL LEAD; AIR-POLLUTION; BLOOD LEAD; PB EXPOSURE AB Recent research has demonstrated that nonchemical stressors may alter the toxicity from chemical exposures. This may have public health implications for low socioeconomic status (SES) communities that may be disproportionately exposed to toxic chemicals and various types of community and personal stressors. Nonchemical stressors may introduce an important source of variability that needs to be considered by risk assessors. Herein, we propose a framework for determining if a chemical-nonchemical interaction exists and, if so, options for incorporating interaction information into risk assessments. We use the increasingly recognized interaction between lead and psychosocial stress to illustrate the framework. We found that lead exposure occurs disproportionately in low SES groups that also tend to face high levels of psychosocial stress; that stress and lead both affect neurodevelopment and that this occurs via similar pathways involving the hypothalamic-pituitary axis. Further, several epidemiological and experimental studies have provided evidence for an interaction between lead and psychosocial stress. The implications of this interaction for risk assessment are also discussed. C1 [Segal, Deborah; Lin, Yu-Sheng; Sonawane, Babasaheb] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Ginsberg, Gary] Connecticut Dept Publ Hlth, Hartford, CT USA. RP Segal, D (reprint author), US EPA, Two Potomac Yard North,2733 Crystal Dr, Arlington, VA 22202 USA. EM segal.deborah@epa.gov NR 118 TC 0 Z9 0 U1 9 U2 38 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD OCT 3 PY 2015 VL 21 IS 7 BP 1840 EP 1868 DI 10.1080/10807039.2014.992852 PG 29 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CK8PI UT WOS:000356500000008 ER PT J AU Oshida, K Vasani, N Thomas, RS Applegate, D Gonzalez, FJ Aleksunes, LM Klaassen, CD Corton, JC AF Oshida, Keiyu Vasani, Naresh Thomas, Russell S. Applegate, Dawn Gonzalez, Frank J. Aleksunes, Lauren M. Klaassen, Curtis D. Corton, J. Christopher TI Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR) SO TOXICOLOGY LA English DT Article DE Aryl hydrocarbon receptor; Peroxisome proliferator-activated receptor; Transcript profiling; Liver cancer; Constitutive activated receptor; Keap1; Nrf2; Pregnane X receptor ID PPAR-ALPHA; CYCLOOXYGENASE-2 EXPRESSION; NONGENOTOXIC CARCINOGENS; RISK-ASSESSMENT; FATTY LIVER; MICE; ACTIVATION; HEPATOCYTES; GLUCOSE; DIOXIN AB The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular steatosis, and chronic activation can lead to liver cancer in mice and rats. Analytical approaches were developed to identify biosets in a genomic database in which AhR activity was altered. A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. A fold-change rank-based test (Running Fisher's test; p-value <= 10(-4)) was used to evaluate the similarity between the AhR biomarker and a test set of 37 and 41 biosets positive or negative, respectively for AhR activation. The test resulted in a balanced accuracy of 95%. The rank-based test was used to identify factors that activate or suppress AhR in an annotated mouse liver/mouse primary hepatocyte gene expression database of similar to 1850 comparisons. In addition to the expected activation of AhR by TCDD and DLC, AhR was activated by AP20189 and phenformin. AhR was suppressed by phenobarbital and 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) in a constitutive activated receptor (CAR)-dependent manner and pregnenolone-16 alpha-carbonitrile in a pregnane X receptor (PXR)-dependent manner. Inactivation of individual genes in nullizygous models led to AhR activation (Pxr, Ghrhr, Taf10) or suppression (Ahr, Ilst6st, Hnf1a). This study describes a novel screening strategy for identifying factors in mouse liver that perturb AhR in a gene expression compendium. Published by Elsevier Ireland Ltd. C1 [Oshida, Keiyu; Vasani, Naresh; Corton, J. Christopher] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. [Thomas, Russell S.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA. [Applegate, Dawn] RegeneMed, San Diego, CA 92121 USA. [Gonzalez, Frank J.] NCI, NIH, Bethesda, MD 20892 USA. [Aleksunes, Lauren M.] Rutgers State Univ, Piscataway, NJ 08854 USA. [Klaassen, Curtis D.] Univ Kansas, Med Ctr, Kansas City, KS 66160 USA. RP Corton, JC (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, 109 TW Alexander Dr MD-B143-06, Res Triangle Pk, NC 27711 USA. EM corton.chris@epa.gov FU U.S. Environmental Protection Agency FX This study was carried out as part of the EPA Chemicals Safety for Sustainability cancer and steatosis AOP projects. We thank Drs. Julian Preston and Charlene McQueen for support, Dr. Jennifer Fostel for archiving the results in CEBS, Dr. William Ward for guidance in analyzing microarray data, Drs. Lyle Burgoon, Susan Hester, Charles Wood and Sheau-Fung Thai for review of the manuscript and Drs. Oliver Hankinson, and Ivan Rusyn for livers from studies carried out in their labs. The information in this document has been funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 69 TC 3 Z9 3 U1 6 U2 21 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD OCT 2 PY 2015 VL 336 BP 99 EP 112 DI 10.1016/j.tox.2015.07.005 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CS4PY UT WOS:000362059600013 PM 26215100 ER PT J AU Beaulieu, JJ Nietch, CT Young, JL AF Beaulieu, Jake J. Nietch, Christopher T. Young, Jade L. TI Controls on nitrous oxide production and consumption in reservoirs of the Ohio River Basin SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES LA English DT Article DE nitrous oxide; nitrification; denitrification; stratification; mixing; turnover ID FRESH-WATER LAKES; NITRATE REDUCTION; HEADWATER STREAMS; METHANE EMISSIONS; TEMPERATE LAKE; N2O EMISSIONS; DENITRIFICATION; DINITROGEN; OXYGEN; ACCUMULATION AB Aquatic ecosystems are a globally significant source of nitrous oxide (N2O), a potent greenhouse gas, but estimates are largely based on studies conducted in streams and rivers with relatively less known about N2O dynamics in reservoirs. Due to long water residence times and high nitrogen (N) loading rates, reservoirs support substantial N processing and therefore may be particularly important sites of N2O production. Predicting N2O emissions from reservoirs is difficult due to complex interactions between microbial N processing in the oxygen-poor hypolimnion and oxygen-rich epilimnion. Here we present the results of a survey of N2O depth profiles in 20 reservoirs draining a broad range of land use conditions in four states in the U.S. Nitrous oxide was supersaturated in the epilimnion of 80% of the reservoirs and was undersaturated in only one, indicating that reservoirs in this region are generally a source of N2O to the atmosphere. Nitrous oxide was undersaturated in the hypolimnion of 10 reservoirs, supersaturated in 9, and transitioned from supersaturation to undersaturation in 1 reservoir that was monitored periodically from midsummer to fall. All reservoirs with a mean hypolimnion nitrate concentration less than 50 mu gNL(-1) showed evidence of net N2O consumption in the hypolimnion. All reservoirs sampled during lake turnover supported N2O production throughout the water column. These results indicate that N2O dynamics in reservoirs differ widely both among systems and through time but can be predicted based on N and oxygen availability and degree of thermal stratification. C1 [Beaulieu, Jake J.; Nietch, Christopher T.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Young, Jade L.] US Army, Corps Engineers, Louisville Dist Water Qual, Louisville, KY USA. RP Beaulieu, JJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM beaulieu.jake@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development FX We thank Kenvirons Inc. for field support. The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded and collaborated in the research described herein. It has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the U.S. Environmental Protection Agency or the U.S. Army Corps of Engineers; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. The data used to produce the results of this paper can be obtained at no charge from the corresponding author. NR 59 TC 5 Z9 5 U1 15 U2 33 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-8953 EI 2169-8961 J9 J GEOPHYS RES-BIOGEO JI J. Geophys. Res.-Biogeosci. PD OCT PY 2015 VL 120 IS 10 BP 1995 EP 2010 DI 10.1002/2015JG002941 PG 16 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA DB7XK UT WOS:000368730300008 ER PT J AU Huang, JQ Christ, JA Goltz, MN Demond, AH AF Huang, Junqi Christ, John A. Goltz, Mark N. Demond, Avery H. TI Modeling NAPL dissolution from pendular rings in idealized porous media SO WATER RESOURCES RESEARCH LA English DT Article ID NONAQUEOUS PHASE LIQUID; SUBSURFACE TRANSPORT-PROPERTIES; ACID SOLUTION CHEMISTRY; MASS-TRANSFER RATES; CAPILLARY-PRESSURE; INTERFACIAL AREA; WETTABILITY; DNAPL; TETRACHLOROETHYLENE; SATURATION AB The dissolution rate of nonaqueous phase liquid (NAPL) often governs the remediation time frame at subsurface hazardous waste sites. Most formulations for estimating this rate are empirical and assume that the NAPL is the nonwetting fluid. However, field evidence suggests that some waste sites might be organic wet. Thus, formulations that assume the NAPL is nonwetting may be inappropriate for estimating the rates of NAPL dissolution. An exact solution to the Young-Laplace equation, assuming NAPL resides as pendular rings around the contact points of porous media idealized as spherical particles in a hexagonal close packing arrangement, is presented in this work to provide a theoretical prediction for NAPL-water interfacial area. This analytic expression for interfacial area is then coupled with an exact solution to the advection-diffusion equation in a capillary tube assuming Hagen-Poiseuille flow to provide a theoretical means of calculating the mass transfer rate coefficient for dissolution at the NAPL-water interface in an organic-wet system. A comparison of the predictions from this theoretical model with predictions from empirically derived formulations from the literature for water-wet systems showed a consistent range of values for the mass transfer rate coefficient, despite the significant differences in model foundations (water wetting versus NAPL wetting, theoretical versus empirical). This finding implies that, under these system conditions, the important parameter is interfacial area, with a lesser role played by NAPL configuration. C1 [Huang, Junqi] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Ada, OK USA. [Christ, John A.] US Air Force Acad, Dept Civil & Environm Engn, Colorado Springs, CO 80840 USA. [Goltz, Mark N.] Air Force Inst Technol, Dept Syst Engn & Management, Wright Patterson AFB, OH USA. [Demond, Avery H.] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. RP Huang, JQ (reprint author), US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Ada, OK USA. EM huang.junqi@epa.gov FU Strategic Environmental Research and Development Program (SERDP) [ER-1737] FX MATLAB (R) codes created for this analysis are available upon request by email: huang.junqi@epa.gov. Portions of this research were supported by the Strategic Environmental Research and Development Program (SERDP), project ER-1737. The authors are grateful for the constructive comments from the Editor and three anonymous reviewers. The content of this manuscript has not been subject to agency review and does not necessarily represent the view of the sponsoring agency. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the United States Air Force, Department of Defense, or the U.S. Government. NR 40 TC 0 Z9 0 U1 6 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD OCT PY 2015 VL 51 IS 10 BP 8182 EP 8197 DI 10.1002/2015WR016924 PG 16 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA DB3NM UT WOS:000368418400020 ER PT J AU Sobus, JR DeWoskin, RS Tan, YM Pleil, JD Phillips, MB George, BJ Christensen, K Schreinemachers, DM Williams, MA Hubal, EAC Edwards, SW AF Sobus, Jon R. DeWoskin, Robert S. Tan, Yu-Mei Pleil, Joachim D. Phillips, Martin Blake George, Barbara Jane Christensen, Krista Schreinemachers, Dina M. Williams, Marc A. Hubal, Elaine A. Cohen Edwards, Stephen W. TI Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID NUTRITION EXAMINATION SURVEY; BIOMONITORING EQUIVALENTS; PHTHALATE METABOLITES; SYSTEMATIC EVALUATION; EXPOSURE-MEASUREMENT; MEASUREMENT ERROR; SUPPORT EXPOSURE; NATIONAL-HEALTH; URINE SAMPLES; BISPHENOL-A AB BACKGROUND: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments. OBJECTIVES: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments. Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends. RESULTS: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts. CONCLUSIONS: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized. C1 [Sobus, Jon R.; Tan, Yu-Mei; Pleil, Joachim D.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [DeWoskin, Robert S.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Phillips, Martin Blake] ORISE Participant, Res Triangle Pk, NC USA. [George, Barbara Jane; Williams, Marc A.; Edwards, Stephen W.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Christensen, Krista] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Schreinemachers, Dina M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Hubal, Elaine A. Cohen] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Sobus, JR (reprint author), 109 TW Alexander Dr,Mail Code E205-04, Res Triangle Pk, NC 27711 USA. EM sobus.jon@epa.gov OI Phillips, Martin/0000-0002-6282-529X FU U.S. Environmental Protection Agency (EPA), through its Office of Research and Development FX The U.S. Environmental Protection Agency (EPA), through its Office of Research and Development, funded and managed the research described here. It has been subjected to Agency administrative review and approved for publication. M. B. P. was supported by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. EPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. NR 68 TC 8 Z9 8 U1 5 U2 26 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2015 VL 123 IS 10 BP 919 EP 927 DI 10.1289/ehp.1409177 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CY8ZW UT WOS:000366698200010 PM 25859901 ER PT J AU Ward-Caviness, CK Kraus, WE Blach, C Haynes, CS Dowdy, E Miranda, ML Devlin, RB Diaz-Sanchez, D Cascio, WE Mukerjee, S Stallings, C Smith, LA Gregory, SG Shah, SH Hauser, ER Neas, L AF Ward-Caviness, Cavin K. Kraus, William E. Blach, Colette Haynes, Carol S. Dowdy, Elaine Miranda, Marie Lynn Devlin, Robert B. Diaz-Sanchez, David Cascio, Wayne E. Mukerjee, Shaibal Stallings, Casson Smith, Luther A. Gregory, Simon G. Shah, Svati H. Hauser, Elizabeth R. Neas, LucasM. TI Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CORONARY-HEART-DISEASE; LONG-TERM EXPOSURE; AIR-POLLUTION EXPOSURE; HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; PARTICULATE MATTER; DIABETES-MELLITUS; ARTERY-DISEASE; PREVALENCE; FRAMINGHAM AB BACKGROUND: The relationship between traffic-related air pollution (TRAP) and risk factors for cardiovascular disease needs to be better understood in order to address the adverse impact of air pollution on human health. OBJECTIVE: We examined associations between roadway proximity and traffic exposure zones, as markers of TRAP exposure, and metabolic biomarkers for cardiovascular disease risk in a cohort of patients undergoing cardiac catheterization. METHODS: We performed a cross-sectional study of 2,124 individuals residing in North Carolina (USA). Roadway proximity was assessed via distance to primary and secondary roadways, and we used residence in traffic exposure zones (TEZs) as a proxy for TRAP. Two categories of metabolic outcomes were studied: measures associated with glucose control, and measures associated with lipid metabolism. Statistical models were adjusted for race, sex, smoking, body mass index, and socioeconomic status (SES). RESULTS: An interquartile-range (990 m) decrease in distance to roadways was associated with higher fasting plasma glucose (beta = 2.17 mg/dL; 95% CI: -0.24, 4.59), and the association appeared to be limited to women (beta = 5.16 mg/dL; 95% CI: 1.48, 8.84 compared with beta = 0.14 mg/dL; 95% CI: -3.04, 3.33 in men). Residence in TEZ 5 (high-speed traffic) and TEZ 6 (stop-and-go traffic), the two traffic zones assumed to have the highest levels of TRAP, was positively associated with high-density lipoprotein cholesterol (HDL-C; beta = 8.36; 95% CI: -0.15, 16.9 and beta = 5.98; 95% CI: -3.96, 15.9, for TEZ 5 and 6, respectively). CONCLUSION: Proxy measures of TRAP exposure were associated with intermediate metabolic traits associated with cardiovascular disease, including fasting plasma glucose and possibly HDL-C. C1 [Ward-Caviness, Cavin K.; Kraus, William E.; Blach, Colette; Haynes, Carol S.; Dowdy, Elaine; Gregory, Simon G.; Shah, Svati H.; Hauser, Elizabeth R.] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC USA. [Kraus, William E.; Shah, Svati H.] Duke Univ, Med Ctr, Div Cardiovasc Med, Durham, NC USA. [Miranda, Marie Lynn] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. [Devlin, Robert B.; Diaz-Sanchez, David; Cascio, Wayne E.; Neas, LucasM.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. [Mukerjee, Shaibal] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Stallings, Casson; Smith, Luther A.] Alion Sci & Technol Inc, Durham, NC USA. [Hauser, Elizabeth R.] Durham Vet Affairs Med Ctr, Epidemiol Res & Informat Ctr, Durham, NC USA. RP Ward-Caviness, CK (reprint author), DUMC Box 3382, Durham, NC 27710 USA. EM cavin.wardcaviness@gmail.com FU National Institutes of Health [HL73042, HL36587, HL095987]; Neurosciences Education and Research Foundation (Encinitas, CA) FX This work was supported by National Institutes of Health grants HL73042, HL36587, and HL095987 and by an award from the Neurosciences Education and Research Foundation (Encinitas, CA). This research was supported by an appointment to the ORISE Research Participation Program for the U.S. EPA, Office of Research and Development. C.S. and L.A.S. are employed by Alion Science and Technology Inc. NR 53 TC 5 Z9 5 U1 4 U2 10 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2015 VL 123 IS 10 BP 1007 EP 1014 DI 10.1289/ehp.1306980 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CY8ZW UT WOS:000366698200022 PM 25807578 ER PT J AU Rappazzo, KM Daniels, JL Messer, LC Poole, C Lobdell, DT AF Rappazzo, Kristen M. Daniels, Julie L. Messer, Lynne C. Poole, Charles Lobdell, Danelle T. TI Exposure to Elemental Carbon, Organic Carbon, Nitrate, and Sulfate Fractions of Fine Particulate Matter and Risk of Preterm Birth in New Jersey, Ohio, and Pennsylvania (2000-2005) SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID AMBIENT AIR-POLLUTION; OUTCOMES; PM2.5; REGRESSION; MORTALITY; FRAMEWORK; RATIOS; RACISM; COHORT; WOMEN AB BACKGROUND: Particulate matter <= 2.5 mu m in aerodynamic diameter (PM2.5) has been consistently associated with preterm birth (PTB) to varying degrees, but roles of PM2.5 species have been less studied. OBJECTIVE: We estimated risk differences (RD) of PTB (reported per 10(6) pregnancies) associated with change in ambient concentrations of elemental carbon (EC), organic carbon (OC), nitrates (NO3), and sulfates (SO4). METHODS: From live birth certificates from three states, we constructed a cohort of singleton pregnancies at or beyond 20 weeks of gestation from 2000 through 2005 (n = 1,771,225; 8% PTB). We estimated mean species exposures for each week of gestation from monitor-corrected Community Multi-Scale Air Quality modeling data. RDs and 95% confidence intervals (CIs) for four PTB categories were estimated for each exposure using linear regression, adjusted for maternal race/ethnicity, marital status, education, age, smoking, maximum temperature, ozone, and season of conception. We also adjusted for other species in multi-species models. RESULTS: RDs varied by exposure window and outcome period. EC was positively associated with PTB after 27 and before 35 weeks of gestation. For example, for a 0.25-mu g/m(3) increase in EC exposure during gestational week 9, RD = 96 (95% CI: -20, 213) and RD = 145 (95% CI: -50, 341) for PTB during weeks 28-31 and 32-34, respectively. Associations with OCs were null or negative. RDs for NO3 were elevated with exposure in early weeks of gestation, and null in later weeks. RDs for SO4 exposure were positively associated with PTB, though magnitude varied across gestational weeks. We observed effect measure modification for associations between EC and PTB by race/ethnicity and smoking status. CONCLUSION: EC and SO4 may contribute to associations between PM2.5 and PTB. Associations varied according to the timing of exposure and the timing of PTB. C1 [Rappazzo, Kristen M.; Daniels, Julie L.; Poole, Charles] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA. [Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community Hlth, Portland, OR 97207 USA. [Lobdell, Danelle T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. RP Rappazzo, KM (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, CB 7435, Chapel Hill, NC 27514 USA. EM rappazzo@ad.unc.edu NR 27 TC 0 Z9 0 U1 4 U2 17 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2015 VL 123 IS 10 BP 1059 EP 1065 DI 10.1289/ehp.1408953 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CY8ZW UT WOS:000366698200029 PM 25910280 ER PT J AU Vasileiadis, S Puglisi, E Trevisan, M Scheckel, KG Langdon, KA McLaughlin, MJ Lombi, E Donner, E AF Vasileiadis, Sotirios Puglisi, Edoardo Trevisan, Marco Scheckel, Kirk G. Langdon, Kate A. McLaughlin, Mike J. Lombi, Enzo Donner, Erica TI Changes in soil bacterial communities and diversity in response to long-term silver exposure SO FEMS MICROBIOLOGY ECOLOGY LA English DT Article DE bacterial diversity; selective pressure; silver; soil ID GRAM-NEGATIVE BACTERIA; SP NOV.; MICROBIAL PROCESSES; MAXIMUM-LIKELIHOOD; CONTAMINATED SOILS; ESCHERICHIA-COLI; ACTIVATED-SLUDGE; METAL TOLERANCE; ORGANIC-MATTER; GEN. NOV. AB Silver-induced selective pressure is becoming increasingly important due to the growing use of silver (Ag) as an antimicrobial agent in biomedical and commercial products. With demonstrated links between environmental resistomes and clinical pathogens, it is important to identify microbial profiles related to silver tolerance/resistance. We investigated the effects of ionic Ag stress on soil bacterial communities and identified resistant/persistent bacterial populations. Silver treatments of 50-400 mg Ag kg(-1) soil were established in five soils. Chemical lability measurements using diffusive gradients in thin-film devices confirmed that significant (albeit decreasing) labile Ag concentrations were present throughout the 9-month incubation period. Synchrotron X-ray absorption near edge structure spectroscopy demonstrated that this decreasing lability was due to changes in the Ag speciation to less soluble forms such as Ag-0 and Ag2S. Real-time PCR and Illumina MiSeq screening of 16S rRNA bacterial genes showed beta-diversity changes, increasing alpha-diversity in response to Ag pressure, and immediate and significant reductions in 16S rRNA gene counts with varying degrees of recovery. These effects were more strongly influenced by exposure time than by Ag dose at these rates. Ag-selected dominant OTUs principally resided in known persister taxa (mainly Gram positive), including metal-tolerant bacteria and slow-growing Mycobacteria. C1 [Vasileiadis, Sotirios; Lombi, Enzo; Donner, Erica] Univ S Australia, CERAR, Mawson Lakes, SA 5095, Australia. [Vasileiadis, Sotirios; Trevisan, Marco] Univ Cattolica Sacro Cuore, Ist Chim Agr & Ambientale, I-29122 Piacenza, Italy. [Puglisi, Edoardo] Univ Cattolica Sacro Cuore, Ist Microbiol, I-29122 Piacenza, Italy. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Langdon, Kate A.; McLaughlin, Mike J.] CSIRO, Minerals Down Under Flagship, Glen Osmond, SA 5064, Australia. RP Vasileiadis, S (reprint author), Univ S Australia, CERAR, Bldg 10,Univ Blvd, Mawson Lakes, SA 5095, Australia. EM sotirios.vasileiadis@unisa.edu.au RI Donner, Erica/A-4809-2012; Vasileiadis, Sotirios/G-4119-2014; Lombi, Enzo/F-3860-2013; McLaughlin, Mike/F-2931-2010 OI Donner, Erica/0000-0001-6465-2233; Scheckel, Kirk/0000-0001-9326-9241; Vasileiadis, Sotirios/0000-0002-2048-8192; Lombi, Enzo/0000-0003-3384-0375; McLaughlin, Mike/0000-0001-6796-4144 FU Australian Research Council [FT100100337, FT130101003]; Jane Gillooly Memorial Award; Cariplo Foundation [2011-1088]; Department of Energy; MRCAT member institutions FX This project was supported by the Australian Research Council (FT100100337 and FT130101003), the Jane Gillooly Memorial Award, and the Cariplo Foundation (project 2011-1088). Part of this research was conducted using beamline ID-10 at the Advanced Photon Source (APS, Argonne, IL, USA). MRCAT operations are supported by the Department of Energy and the MRCAT member institutions. NR 108 TC 4 Z9 4 U1 10 U2 36 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0168-6496 EI 1574-6941 J9 FEMS MICROBIOL ECOL JI FEMS Microbiol. Ecol. PD OCT PY 2015 VL 91 IS 10 AR fiv114 DI 10.1093/femsec/fiv114 PG 11 WC Microbiology SC Microbiology GA CY7OO UT WOS:000366598300012 ER PT J AU Evenson, GR Golden, HE Lane, CR D'Amico, E AF Evenson, Grey R. Golden, Heather E. Lane, Charles R. D'Amico, Ellen TI Geographically isolated wetlands and watershed hydrology: A modified model analysis SO JOURNAL OF HYDROLOGY LA English DT Article DE Geographically isolated wetlands; Non-floodplain wetlands; Non-adjacent wetlands; Hydrologic connectivity; Watershed model; Soil and Water Assessment Tool (SWAT) ID SOUTHEASTERN UNITED-STATES; DEPRESSIONAL WETLANDS; SOUTH-CAROLINA; COASTAL-PLAIN; CONNECTIVITY; SWAT; LANDSCAPE; STORAGE; USA; SIMULATIONS AB Geographically isolated wetlands (GIWs) are defined as wetlands that are completely surrounded by uplands. While GIWs are therefore spatially isolated, field-based studies have observed a continuum of hydrologic connections between these systems and other surface waters. Yet few studies have quantified the watershed-scale aggregate effects of GIWs on downstream hydrology. Further, existing modeling approaches to evaluate GIW effects at a watershed scale have utilized conceptual or spatially disaggregated wetland representations. Working towards wetland model representations that use spatially explicit approaches may improve current scientific understanding concerning GIW effects on the downstream hydrograph. The objective of this study was to quantify the watershed-scale aggregate effects of GIWs on downstream hydrology while emphasizing a spatially explicit representation of GIWs and GIW connectivity relationships. We constructed a hydrologic model for a similar to 202 km(2) watershed in the Coastal Plain of North Carolina, USA, a watershed with a substantial population of GIWs, using the Soil and Water Assessment Tool (SWAT). We applied a novel representation of GIWs within the model, facilitated by an alternative hydrologic response unit (HRU) definition and modifications to the SWAT source code that extended the model's "pothole" representation. We then executed a series of scenarios to assess the downstream hydrologic effect of various distributions of GIWs within the watershed. Results suggest that: (1) GIWs have seasonally dependent effects on baseflow; (2) GIWs mitigate peak flows; and (3) The presence of GIWs on the landscape impacts the watershed water balance. This work demonstrates a means of GIW simulation with improved spatial detail while showing that GIWs, in-aggregate, have a substantial effect on downstream hydrology in the studied watershed. (C) 2015 Elsevier B.V. All rights reserved. C1 [Evenson, Grey R.] US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Golden, Heather E.; Lane, Charles R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [D'Amico, Ellen] CSS Dynam Corp, Cincinnati, OH USA. RP Evenson, GR (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Exposure Res Lab,Ecol Exposure Res Div, 26 W Martin Luther King Dr,MS 592, Cincinnati, OH 45268 USA. EM evenson.grey@epa.gov FU Office of Research and Development, U.S. Environmental Protection Agency FX We appreciate helpful suggestions from Keith Sawicz, Rose Kwok, and from anonymous journal reviewers. This paper has been reviewed in accordance with the U.S. Environmental Protection Agency's peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Statements in this publication reflect the authors' professional views and opinions and should not be construed to represent any determination or policy of the U.S. Environmental Protection Agency. This paper was supported in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 71 TC 5 Z9 6 U1 8 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD OCT PY 2015 VL 529 BP 240 EP 256 DI 10.1016/j.jhydrol.2015.07.039 PN 1 PG 17 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CV4PK UT WOS:000364248800019 ER PT J AU Augustine, SAJ Simmons, KJ Eason, TN Griffin, SM Curioso, CL Wymer, LJ Fout, GS Grimm, AC Oshima, KH Dufour, A AF Augustine, Swinburne A. J. Simmons, Kaneatra J. Eason, Tarsha N. Griffin, Shannon M. Curioso, Clarissa L. Wymer, Larry J. Fout, G. Shay Grimm, Ann C. Oshima, Kevin H. Dufour, Al TI Statistical approaches to developing a multiplex immunoassay for determining human exposure to environmental pathogens SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE Multiplex immunoassay; Assay optimization; Design of Experiments (DOE); Response surface methods (RSM); Finite mixed modeling (FMM) ID NEUTRALIZING ANTIBODIES; MIXTURE-MODELS; DESIGN; OPTIMIZATION; ASSAY; PLATFORMS; SERUM AB There are numerous pathogens that can be transmitted through water. Identifying and understanding the routes and magnitude of exposure or infection to these microbial contaminants are critical to assessing and mitigating risk. Conventional approaches of studying immunological responses to exposure or infection such as Enzyme-Linked Immunosorbent Assays (ELISAs) and other monoplex antibody-based immunoassays can be very costly, laborious, and consume large quantities of patient sample. A major limitation of these approaches is that they can only be used to measure one analyte at a time. Multiplex immunoassays provide the ability to study multiple pathogens simultaneously in microliter volumes of samples. However, there are several challenges that must be addressed when developing these multiplex immunoassays such as selection of specific antigens and antibodies, cross-reactivity, calibration, protein-reagent interferences, and the need for rigorous optimization of protein concentrations. In this study, a Design of Experiments (DOE) approach was used to optimize reagent concentrations for coupling selected antigens to Luminex (TM) xMAP microspheres for use in an indirect capture, multiplex immunoassay to detect human exposure or infection from pathogens that are potentially transmitted through water. Results from Helicobacter pylori, Campylobacter jejuni, Escherichia coli 0157:H7, and Salmonella typhimurium singleplexes were used to determine the mean concentrations that would be applied to the multiplex assay. Cut-offs to differentiate between exposed and non-exposed individuals were determined using finite mixed modeling (FMM). The statistical approaches developed facilitated the detection of Immunoglobulin G (IgG) antibodies to H. pylori, C. jejuni, Toxoplasma gondii, hepatitis A virus, rotavirus and noroviruses (VA387 and Norwalk strains) in fifty-four diagnostically characterized plasma samples. Of the characterized samples, the detection rate was 87.5% for H. pylori, and 100% for T. gondii assays and 89% for HAV. Further, the optimized multiplex assay revealed exposure/infection to several other environmental pathogens previously uncharacterized in the samples. Published by Elsevier B.V. C1 [Augustine, Swinburne A. J.; Simmons, Kaneatra J.; Griffin, Shannon M.; Wymer, Larry J.; Fout, G. Shay; Grimm, Ann C.; Oshima, Kevin H.; Dufour, Al] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Eason, Tarsha N.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Curioso, Clarissa L.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Augustine, SAJ (reprint author), 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM augustine.swinburne@epa.gov OI CORIMANYA, GILMAR OCTAVIO/0000-0003-0996-4183 NR 20 TC 1 Z9 1 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD OCT PY 2015 VL 425 BP 1 EP 9 DI 10.1016/j.jim.2015.06.002 PG 9 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA CU8UM UT WOS:000363819600001 PM 26070441 ER PT J AU Fisher, JC Eren, AM Green, HC Shanks, OC Morrison, HG Vineis, JH Sogin, ML McLellan, SL AF Fisher, Jenny C. Eren, A. Murat Green, Hyatt C. Shanks, Orin C. Morrison, Hilary G. Vineis, Joseph H. Sogin, Mitchell L. McLellan, Sandra L. TI Comparison of Sewage and Animal Fecal Microbiomes by Using Oligotyping Reveals Potential Human Fecal Indicators in Multiple Taxonomic Groups SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID 16S RIBOSOMAL-RNA; SOURCE TRACKING; GENETIC-MARKERS; GUT MICROBIOME; QUANTITATIVE DETECTION; SURFACE WATERS; PCR ASSAY; POLLUTION; BACTEROIDALES; FECES AB Most DNA-based microbial source tracking (MST) approaches target host-associated organisms within the order Bacteroidales, but the gut microbiota of humans and other animals contain organisms from an array of other taxonomic groups that might provide indicators of fecal pollution sources. To discern between human and nonhuman fecal sources, we compared the V6 regions of the 16S rRNA genes detected in fecal samples from six animal hosts to those found in sewage (as a proxy for humans). We focused on 10 abundant genera and used oligotyping, which can detect subtle differences between rRNA gene sequences from ecologically distinct organisms. Our analysis showed clear patterns of differential oligotype distributions between sewage and animal samples. Over 100 oligotypes of human origin occurred preferentially in sewage samples, and 99 human oligotypes were sewage specific. Sequences represented by the sewage-specific oligotypes can be used individually for development of PCR-based assays or together with the oligotypes preferentially associated with sewage to implement a signature-based approach. Analysis of sewage from Spain and Brazil showed that the sewage-specific oligotypes identified in U.S. sewage have the potential to be used as global alternative indicators of human fecal pollution. Environmental samples with evidence of prior human fecal contamination had consistent ratios of sewage signature oligotypes that corresponded to the trends observed for sewage. Our methodology represents a promising approach to identifying new bacterial taxa for MST applications and further highlights the potential of the family Lachnospiraceae to provide human-specific markers. In addition to source tracking applications, the patterns of the fine-scale population structure within fecal taxa suggest a fundamental relationship between bacteria and their hosts. C1 [Fisher, Jenny C.; McLellan, Sandra L.] Univ Wisconsin, Sch Freshwater Sci, Milwaukee, WI 53201 USA. [Eren, A. Murat; Morrison, Hilary G.; Vineis, Joseph H.; Sogin, Mitchell L.] Marine Biol Lab, Josephine Bay Paul Ctr, Woods Hole, MA 02543 USA. [Green, Hyatt C.] SUNY Coll Environm Sci & Forestry, Syracuse, NY USA. [Shanks, Orin C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP McLellan, SL (reprint author), Univ Wisconsin, Sch Freshwater Sci, Milwaukee, WI 53201 USA. EM mclellan@uwm.edu OI Eren, A. Murat/0000-0001-9013-4827; Morrison, Hilary/0000-0003-0281-326X FU National Institutes of Health grant [R01AI091829-01A1] FX Funding for this project was provided by a National Institutes of Health grant (R01AI091829-01A1) to S.L.M. NR 56 TC 7 Z9 7 U1 5 U2 25 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 2015 VL 81 IS 20 BP 7023 EP 7033 DI 10.1128/AEM.01524-15 PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CU3YC UT WOS:000363461300009 PM 26231648 ER PT J AU Miller-Schulze, JP Shafer, M Schauer, JJ Heo, JB Solomon, PA Lantz, J Artamonova, M Chen, B Imashev, S Sverdlik, L Carmichael, G DeMinter, J AF Miller-Schulze, Justin P. Shafer, Martin Schauer, James J. Heo, Jongbae Solomon, Paul A. Lantz, Jeffrey Artamonova, Maria Chen, Boris Imashev, Sanjar Sverdlik, Leonid Carmichael, Greg DeMinter, Jeff TI Seasonal contribution of mineral dust and other major components to particulate matter at two remote sites in Central Asia SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Mineral dust; Dust storms; Particulate matter ID FINE PARTICLES; ACE-ASIA; PM2.5; POLLUTION; AEROSOLS; CHINA; PM10; ASSOCIATION; SIGNATURES; HOUSTON AB Dust storms are significant contributors to ambient levels of particulate matter (PM) in many areas of the world. Central Asia, an area that is relatively understudied in this regard, is anticipated to be affected by dust storms due to its proximity to several major deserts that are in and generally surround Central Asia (e.g., the Aral Sea region, the Taklimakan desert in Western China). To investigate the relative importance of mineral dust (dust specifically composed of soil related minerals and oxides) in Central Asia, PM10 and PM2.5, and by difference, coarse particles (particles with diameters between 2.5 and 10 gm) were measured at two sites, Bishkek and Lidar Station Teplokluchenka (Lidar), in the Kyrgyz Republic. Samples were collected every other day from July 2008 to July 2009. Daily samples were analyzed for mass and organic and elemental carbon. Samples were also composited on a bi-weekly basis and analyzed for elemental constituents and ionic components. In addition, samples collected on days with relatively high and low PM concentrations were analyzed before, and separately, from the biweekly composites to investigate the chemical differences between the episodic events. Data from the episodic samples were averaged into the composited averages. Using the elemental component data, several observational models were examined to estimate the contribution of mineral dust to ambient PM levels. A mass balance was also conducted. Results indicate that at both sites, mineral dust (as approximated by the "dust oxide" model) and organic matter (OM) were the dominant contributors to PM10 and PM2.5. Mineral dust was a more significant contributor to the coarse PM (PM10-2.5) during high event samples at both sites, although the relative contribution is greater at the Lidar site (average +/- standard deviation = 42 +/- 29%) as compared with the Bishkek site (26 +/- 16%). Principal Components Analysis (PCA) was performed using data from both sites, and PCA indicated that mineral dust explained the majority of the variance in PM concentrations, and that the major apportioned factors of PM10 and PM2.5 were chemically similar between sites. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Miller-Schulze, Justin P.; Shafer, Martin; Schauer, James J.; DeMinter, Jeff] Wisconsin State Lab Hyg, Madison, WI 53718 USA. [Miller-Schulze, Justin P.; Shafer, Martin; Schauer, James J.; Heo, Jongbae] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA. [Solomon, Paul A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA. [Lantz, Jeffrey] US EPA, Off Radiat & Indoor Air, Las Vegas, NV 89193 USA. [Artamonova, Maria] Russian Acad Sci, Inst Atmospher Phys, Moscow 109017, Russia. [Chen, Boris; Imashev, Sanjar; Sverdlik, Leonid] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan. [Carmichael, Greg] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA. RP Shafer, M (reprint author), Univ Wisconsin, 660 N Pk St, Madison, WI 53706 USA. EM mmshafer@wisc.edu RI Imashev, Sanjar/I-7667-2016 OI Imashev, Sanjar/0000-0003-3293-3764 FU Association of Public Health Laboratories (APHL); Wisconsin State Laboratory of Hygiene; US Environmental Protection Agency through its Office of Research and Development [EP-D-06-001, 3715] FX We would like to acknowledge the Association of Public Health Laboratories (APHL) for funding through their Environmental Health Fellows program at the University of Wisconsin-Madison and Wisconsin State Laboratory of Hygiene in support of Justin P. Miller-Schulze. The US Environmental Protection Agency through its Office of Research and Development funded this study and collaborated in the research described here under Contract EP-D-06-001 to the University of Wisconsin-Madison) as a component of the International Science & Technology Center (ISTC) project # 3715 (Transcontinental Transport of Air Pollution from Central Asia to the US). It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement, certification, or recommendation for use. NR 33 TC 2 Z9 3 U1 4 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD OCT PY 2015 VL 119 BP 11 EP 20 DI 10.1016/j.atmosenv.2015.07.011 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CT8PJ UT WOS:000363078200002 ER PT J AU Meloto, CB Segall, SK Smith, S Parisien, M Shabalina, SA Rizzatti-Barbosa, CM Gauthier, J Tsao, D Convertino, M Piltonen, MH Slade, GD Fillingim, RB Greenspan, JD Ohrbach, R Knott, C Maixner, W Zaykin, D Dokholyan, NV Reenila, I Mannisto, PT Diatchenko, L AF Meloto, Carolina B. Segall, Samantha K. Smith, Shad Parisien, Marc Shabalina, Svetlana A. Rizzatti-Barbosa, Celia M. Gauthier, Josee Tsao, Douglas Convertino, Marino Piltonen, Marjo H. Slade, Gary Dmitri Fillingim, Roger B. Greenspan, Joel D. Ohrbach, Richard Knott, Charles Maixner, William Zaykin, Dmitri Dokholyan, Nikolay V. Reenilae, Ilkka Mannistoe, Pekka T. Diatchenko, Luda TI COMT gene locus: new functional variants SO PAIN LA English DT Article DE Association study; Chronic pain; COMT; Functional polymorphism; Genetics ID CATECHOL-O-METHYLTRANSFERASE; RNA SECONDARY STRUCTURE; MOLECULAR-DYNAMICS SIMULATIONS; ALTERNATIVE TRANSCRIPTION; PAIN SENSITIVITY; SIRNA DESIGN; RISK-FACTORS; EXPRESSION; EVOLUTION; ASSOCIATIONS AB Catechol-O-methyltransferase (COMT) metabolizes catecholaminergic neurotransmitters. Numerous studies have linked COMT to pivotal brain functions such as mood, cognition, response to stress, and pain. Both nociception and risk of clinical pain have been associated with COMT genetic variants, and this association was shown to be mediated through adrenergic pathways. Here, we show that association studies between COMT polymorphic markers and pain phenotypes in 2 independent cohorts identified a functional marker; rs165774, situated in the 3' untranslated region of a newfound splice variant, (a)-COMT. Sequence comparisons showed that the (a)-COMT transcript is highly conserved in primates, and deep sequencing data demonstrated that (a)-COMT is expressed across several human tissues, including the brain. In silico analyses showed that the (a)-COMT enzyme features a distinct C-terminus structure, capable of stabilizing substrates in its active site. In vitro experiments demonstrated not only that (a)-COMT is catalytically active but also that it displays unique substrate specificity, exhibiting enzymatic activity with dopamine but not epinephrine. They also established that the pain-protective A allele of rs165774 coincides with lower COMT activity, suggesting contribution to decreased pain sensitivity through increased dopaminergic rather than decreased adrenergic tone, characteristic of reference isoforms. Our results provide evidence for an essential role of the (a)-COMT isoform in nociceptive signaling and suggest that genetic variations in (a)-COMT isoforms may contribute to individual variability in pain phenotypes. C1 [Meloto, Carolina B.; Parisien, Marc; Piltonen, Marjo H.; Diatchenko, Luda] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. [Segall, Samantha K.; Smith, Shad; Tsao, Douglas; Slade, Gary Dmitri; Maixner, William; Dokholyan, Nikolay V.] Univ N Carolina, Ctr Pain Res & Innovat, Chapel Hill, NC USA. [Shabalina, Svetlana A.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. [Rizzatti-Barbosa, Celia M.] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Prosthesis & Periodontol, Piracicaba, SP, Brazil. [Gauthier, Josee] Univ Florida, Coll Med, Dept Med, Div Gastroenterol, Gainesville, FL USA. [Convertino, Marino] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC USA. [Fillingim, Roger B.; Dokholyan, Nikolay V.] Univ Florida, Coll Dent, Dept Community Dent & Behav Sci, Gainesville, FL USA. [Fillingim, Roger B.] Pain Res & Intervent Ctr Excellence, Gainesville, FL USA. [Greenspan, Joel D.] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA. [Greenspan, Joel D.] Univ Maryland, Sch Dent, Brotman Facial Pain Clin, Baltimore, MD 21201 USA. [Ohrbach, Richard] SUNY Buffalo, Dept Oral Diagnost Sci, Buffalo, NY 14260 USA. [Knott, Charles] Battelle Ctr Publ Hlth Res & Evaluat CPHRE, Battelle Mem Inst, Durham, NC USA. [Zaykin, Dmitri] Natl Inst Environm Hlth Sci, Durham, NC USA. [Reenilae, Ilkka; Mannistoe, Pekka T.] Univ Helsinki, Fac Pharm, Div Pharmacol & Pharmacotherapy, Helsinki, Finland. RP Diatchenko, L (reprint author), 740 Ave Dr Penfield,Room 2200, Montreal, PQ H3A 0G1, Canada. EM luda.diatchenko@mcgill.ca OI Greenspan, Joel/0000-0003-4062-9797; Reenila, Ilkka/0000-0002-9390-7351 FU Intramural Research Program of the National Library of Medicine, NIH FX The authors thank all participants from the TMD case-control and OPPERA cohorts for their contribution. The authors acknowledge Dr. Bruce Weir for his contribution for the genetic design of the OPPERA cohort, and Ms. Liisa Lappalainen, MSc, for running the high-performance liquid chromatography for the COMT activity assays shown here. This research was supported in part by the Intramural Research Program of the National Library of Medicine, NIH. NR 58 TC 2 Z9 2 U1 3 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD OCT PY 2015 VL 156 IS 10 BP 2072 EP 2083 DI 10.1097/j.pain.0000000000000273 PG 12 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA CU2OG UT WOS:000363362200026 PM 26207649 ER PT J AU Blumenfeld, J AF Blumenfeld, Jared TI California: Water Quality, Trash Removal and Marine Debris SO SEA TECHNOLOGY LA English DT Editorial Material C1 US EPA, San Francisco, CA 94105 USA. RP Blumenfeld, J (reprint author), US EPA, San Francisco, CA 94105 USA. NR 0 TC 0 Z9 0 U1 3 U2 9 PU COMPASS PUBLICATIONS, INC PI ARLINGTON PA 1501 WILSON BLVD., STE 1001, ARLINGTON, VA 22209-2403 USA SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD OCT PY 2015 VL 56 IS 10 BP 7 EP 7 PG 1 WC Engineering, Ocean SC Engineering GA CU5WT UT WOS:000363603400001 ER PT J AU Boehm, AB Soller, JA Shanks, OC AF Boehm, Alexandria B. Soller, Jeffrey A. Shanks, Orin C. TI Human-Associated Fecal Quantitative Polymerase Chain Reaction Measurements and Simulated Risk of Gastrointestinal Illness in Recreational Waters Contaminated with Raw Sewage SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID MICROBIAL SOURCE TRACKING; BACTEROIDALES GENETIC-MARKERS; ESCHERICHIA-COLI O157-H7; PCR-BASED ASSAYS; REAL-TIME PCR; INDICATOR BACTERIA; DOSE-RESPONSE; CAMPYLOBACTER-JEJUNI; COASTAL WATERS; PATHOGEN RISK AB We used quantitative microbial risk assessment to simulate the risk of gastrointestinal (GI) illness associated with swimming in waters containing different concentrations of human-associated fecal markers from raw sewage, HF183 and HumM2. The volume/volume ratio of raw sewage to ambient water was determined by comparing marker concentrations in recreational water to concentrations in raw sewage from 54 geographic locations across the United States. Concentrations of reference GI pathogens in raw sewage, volumes ingested by swimmers, dose-response functions, and fractions of infected that become ill were adopted from previous studies. Simulated GI risk increased with concentration of the human quantitative polymerase chain reaction markers in recreational waters. A benchmark illness rate of 30 GI illnesses per 1000 swimmers occurred at median concentrations of 4200 copies of HF183 and 2800 copies of HumM2 per 100 mL of recreational water. This study establishes a risk-based approach for interpreting concentrations of human fecal markers in ambient waters. C1 [Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Environm & Water Studies, Stanford, CA 94305 USA. [Soller, Jeffrey A.] Soller Environm, Berkeley, CA 94703 USA. [Shanks, Orin C.] US Environm Protect Agcy Off Res & Dev, Cincinnati, OH 45268 USA. RP Boehm, AB (reprint author), Stanford Univ, Dept Civil & Environm Engn, Environm & Water Studies, Stanford, CA 94305 USA. EM aboehm@stanford.edu FU National Science Foundation [OCE-1129270] FX Information has been subjected to U.S. EPA peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the official positions and policies of the U.S. EPA. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. A.B.B. was supported by National Science Foundation Grant OCE-1129270. NR 60 TC 4 Z9 4 U1 6 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD OCT PY 2015 VL 2 IS 10 BP 270 EP 275 DI 10.1021/acs.estlett.5b00219 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CT6NW UT WOS:000362930700003 ER PT J AU Munns, WR Rea, AW Mazzotta, MJ Wainger, LA Saterson, K AF Munns, Wayne R., Jr. Rea, Anne W. Mazzotta, Marisa J. Wainger, Lisa A. Saterson, Kathryn TI Toward a Standard Lexicon for Ecosystem Services SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Definitions; Ecological benefits; Ecosystem services; Environmental decision making; Terminology ID DECISION-MAKING; CLASSIFICATION; BIODIVERSITY; METAANALYSIS; VALUATION; GOODS AB The complex, widely dispersed, and cumulative environmental challenges currently facing society require holistic, transdisciplinary approaches to resolve. The concept of ecosystem services (ES) has become more widely accepted as a framework that fosters a broader systems perspective of sustainability and can make science more responsive to the needs of decision makers and the public. Successful transdisciplinary approaches require a common language and understanding of key concepts. Our primary objective is to encourage the ES research and policy communities to standardize terminology and definitions, to facilitate mutual understanding by multidisciplinary researchers and policy makers. As an important step toward standardization, we present a lexicon developed to inform ES research conducted by the US Environmental Protection Agency and its partners. We describe a straightforward conceptualization of the relationships among environmental decisions, their effects on ecological systems and the services they provide, and human well-being. This provides a framework for common understanding and use of ES terminology. We encourage challenges to these definitions and attempts to advance standardization of a lexicon in ways that might be more meaningful to our ultimate objective: informing environmental decisions in ways that promote the sustainability of the environment upon which we all depend. Published 2015 SETAC. This article is a US Government work and, as such, is in the public domain in the USA. C1 [Munns, Wayne R., Jr.; Mazzotta, Marisa J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA. [Rea, Anne W.] US EPA, Off Res & Dev, Safe & Sustainable Water Resources Res Program, Res Triangle Pk, NC 27711 USA. [Wainger, Lisa A.] Univ Maryland, Ctr Environm Sci, Solomons, MD USA. [Saterson, Kathryn] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Munns, WR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA. EM munns.wayne@epa.gov OI Wainger, Lisa/0000-0002-3983-8850 NR 55 TC 6 Z9 6 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD OCT PY 2015 VL 11 IS 4 BP 666 EP 673 DI 10.1002/ieam.1631 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CT5KN UT WOS:000362848700014 PM 25689771 ER PT J AU Biales, AD Denton, DL Riordan, D Breuer, R Batt, AL Crane, DB Schoenfuss, HL AF Biales, Adam D. Denton, Debra L. Riordan, Dan Breuer, Richard Batt, Angela L. Crane, David B. Schoenfuss, Heiko L. TI Complex Watersheds, Collaborative Teams: Assessing Pollutant Presence and Effects in the San Francisco Delta SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Alternative endpoints; Biomarkers; Gene expression; Integrated assessment; Watershed assessment ID MINNOW PIMEPHALES-PROMELAS; ADVERSE OUTCOME PATHWAYS; PERSONAL CARE PRODUCTS; WASTE-WATER; FATHEAD MINNOW; PYRETHROID INSECTICIDES; PHARMACEUTICALS; VITELLOGENIN; FISH; EXPRESSION AB There is a great diversity of sources of chemical contaminants and stressors over large geographic areas. Chemical contaminant inputs and magnitude can potentially exhibit wide seasonal variation over large geographic areas. Together, these factors make linking exposure to monitored chemical contaminants and effects difficult. In practice, this linkage typically relies on relatively limited chemical occurrence data loosely coupled with individual effects, and population- or community-level assessments. Increased discriminatory power may be gained by approaching watershed level assessment in a more holistic manner, drawing from a number of disciplines that target endpoints spanning levels of the biological hierarchy. Using the Sacramento River as a case study, the present study aimed to 1) evaluate the performance of new analytical and biomarker tools in a real world setting and their potential for linking occurrence and effect; 2) characterize the effects of geographic and temporal variability through the integration of suborganismal, tissue, and individual level endpoints, as well as extensive chemical analyses; 3) identify knowledge gaps and research needs that limit the implementation of this holistic approach; and 4) provide an experimental design workflow for these types of assessments. Sites were selected to target inputs into the Sacramento River as it transitions from an agricultural to a mixed but primarily urban landscape. Chemical analyses were conducted on surface water samples at each site in both the spring and fall for pesticides, hormones, and active pharmaceutical ingredients (APIs). Active pharmaceutical ingredients were more often detected across sampling events in the fall; however, at the most downstream site the number of analytes detected and their concentrations were greater in the spring, which may be due to seasonal differences in rainfall. Changes in gene and protein expression targeting endocrine and reproductive effects were observed within each sampling event; however, they were inconsistent across seasons. Larval mortality at the most downstream site was seen in both seasons; however, behavioral changes were only observed in the spring. No clear linkages of specific analyte exposure to biological response were observed, nor were linkages across biological levels of organization. This failure may have resulted from limitations of the scope of molecular endpoints used, inconsistent timing of exposure, or discordance of analytical chemistry through grab sampling and longer term, integrative exposure. Together, results indicate a complicated view of the watershed. (C) 2015 SETAC C1 [Biales, Adam D.; Batt, Angela L.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Denton, Debra L.] US EPA, Sacramento, CA USA. [Riordan, Dan] Calif Dept Water Resources, West Sacramento, CA USA. [Breuer, Richard] State Water Resources Control Board, Sacramento, CA USA. [Crane, David B.] Calif Dept Fish & Wildlife, Rancho Cordova, CA USA. [Schoenfuss, Heiko L.] St Cloud State Univ, Aquat Toxicol Lab, St Cloud, MN 56301 USA. RP Biales, AD (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM biales.adam@epa.gov NR 42 TC 1 Z9 1 U1 3 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD OCT PY 2015 VL 11 IS 4 BP 674 EP 688 DI 10.1002/ieam.1633 PG 15 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CT5KN UT WOS:000362848700015 PM 25779725 ER PT J AU Rochelle, PA Klonicki, PT Di, GD Hill, VR Akagi, Y Villegas, EN AF Rochelle, Paul A. Klonicki, Patricia T. Di, George D. Hill, Vincent R. Akagi, Yone Villegas, Eric N. TI Conference Report: The 6th International Symposium on Waterborne Pathogens SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article ID DRINKING-WATER; UNITED-STATES; OUTBREAK; DISEASE C1 [Rochelle, Paul A.] MWDSC, La Verne, CA USA. [Klonicki, Patricia T.] CSC, Cincinnati, OH 45242 USA. [Di, George D.] Univ Texas Houston, Sch Publ Hlth, El Paso, TX USA. [Hill, Vincent R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Akagi, Yone] Portland Water Bur, Portland, OR USA. [Villegas, Eric N.] US Environm Protect Agcy, Cincinnati, OH USA. RP Klonicki, PT (reprint author), CSC, Cincinnati, OH 45242 USA. EM pklonicki@csc.com RI Villegas, Eric/A-7373-2015 OI Villegas, Eric/0000-0002-8059-8588 FU Intramural CDC HHS [CC999999] NR 9 TC 0 Z9 0 U1 0 U2 3 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD OCT PY 2015 VL 107 IS 10 BP 24 EP 32 DI 10.5942/jawwa.2015.107.0156 PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CT3GR UT WOS:000362695700006 PM 26566291 ER PT J AU Rice, EW AF Rice, Eugene W. TI Occurrence and Control of Tularemia in Drinking Water SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Editorial Material C1 US EPA, Cincinnati, OH 45268 USA. RP Rice, EW (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM rice.gene@epa.gov NR 0 TC 0 Z9 0 U1 3 U2 3 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD OCT PY 2015 VL 107 IS 10 BP 74 EP 74 DI 10.5942/jawwa.2015.107.0130 PG 1 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CT3GR UT WOS:000362695700012 ER PT J AU Johnson, T Butcher, J Deb, D Faizullabhoy, M Hummel, P Kittle, J McGinnis, S Mearns, LO Nover, D Parker, A Sarkar, S Srinivasan, R Tuppad, P Warren, M Weaver, C Witt, J AF Johnson, T. Butcher, J. Deb, D. Faizullabhoy, M. Hummel, P. Kittle, J. McGinnis, S. Mearns, L. O. Nover, D. Parker, A. Sarkar, S. Srinivasan, R. Tuppad, P. Warren, M. Weaver, C. Witt, J. TI Modeling Streamflow and Water Quality Sensitivity to Climate Change and Urban Development in 20 US Watersheds SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE climate change; urban and residential development; streamflow; water quality; sensitivity; assessment; Soil and Water Assessment Tool ID ATMOSPHERIC CARBON-DIOXIDE; CHANGE IMPACTS; UNITED-STATES; STOMATAL CONDUCTANCE; EPIC MODEL; CO2; PRECIPITATION; PROJECTIONS; CATCHMENT; HYDROLOGY AB Watershed modeling in 20 large, United States (U.S.) watersheds addresses gaps in our knowledge of streamflow, nutrient (nitrogen and phosphorus), and sediment loading sensitivity to mid-21st Century climate change and urban/residential development scenarios. Use of a consistent methodology facilitates regional scale comparisons across the study watersheds. Simulations use the Soil and Water Assessment Tool. Climate change scenarios are from the North American Regional Climate Change Assessment Program dynamically downscaled climate model output. Urban and residential development scenarios are from U.S. Environmental Protection Agency's Integrated Climate and Land Use Scenarios project. Simulations provide a plausible set of streamflow and water quality responses to mid-21st Century climate change across the U.S. Simulated changes show a general pattern of decreasing streamflow volume in the central Rockies and Southwest, and increases on the East Coast and Northern Plains. Changes in pollutant loads follow a similar pattern but with increased variability. Ensemble mean results suggest that by the mid-21st Century, statistically significant changes in streamflow and total suspended solids loads (relative to baseline conditions) are possible in roughly 30-40% of study watersheds. These proportions increase to around 60% for total phosphorus and total nitrogen loads. Projected urban/residential development, and watershed responses to development, are small at the large spatial scale of modeling in this study. C1 [Johnson, T.; Weaver, C.; Witt, J.] US EPA, Res & Dev, Washington, DC 20460 USA. [Butcher, J.; Sarkar, S.] Tetra Tech Inc, Res Triangle Pk, NC 27709 USA. [Deb, D.; Srinivasan, R.; Tuppad, P.] Texas A&M Univ, Spatial Sci Lab, Ecosyst Sci & Management, College Stn, TX 77845 USA. [Faizullabhoy, M.; Parker, A.] Tetra Tech Inc, Fairfax, VA 22030 USA. [Hummel, P.; Kittle, J.] AQUA TERRA Consultants, Decatur, GA 30030 USA. [McGinnis, S.; Mearns, L. O.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Nover, D.; Warren, M.] US EPA, Washington, DC 20460 USA. [Nover, D.] Agcy Int Dev, West African Reg Off, Accra 09817, Ghana. [Warren, M.] USGS CIDA, Middleton, WI 53562 USA. RP Johnson, T (reprint author), US EPA, Res & Dev, 1200 Pennsylvania Ave NW,MC8601P, Washington, DC 20460 USA. EM johnson.thomas@epa.gov RI Weaver, Christopher/G-3714-2010; Srinivasan, R/D-3937-2009; OI Weaver, Christopher/0000-0003-4016-5451; McGinnis, Seth/0000-0001-8082-834X NR 67 TC 7 Z9 7 U1 10 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2015 VL 51 IS 5 BP 1321 EP 1341 DI 10.1111/1752-1688.12308 PG 21 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CS8WG UT WOS:000362369900012 ER PT J AU Vineyard, D Ingwersen, WW Hawkins, TR Xue, XB Demeke, B Shuster, W AF Vineyard, Donald Ingwersen, Wesley W. Hawkins, Troy R. Xue, Xiaobo Demeke, Bayou Shuster, William TI Comparing Green and Grey Infrastructure Using Life Cycle Cost and Environmental Impact: A Rain Garden Case Study in Cincinnati, OH SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE watershed management; stormwater management; sustainable technology; rain garden; best management practices; life cycle assessment; life cycle costing ID GROUNDWATER RECHARGE; STORMWATER RUNOFF; WATER-QUALITY; INFILTRATION; BIORETENTION; PERFORMANCE; MANAGEMENT; SYSTEMS; BENEFITS; FLOW AB Green infrastructure (GI) is quickly gaining ground as a less costly, greener alternative to traditional methods of stormwater management. One popular form of GI is the use of rain gardens to capture and treat stormwater. We used life cycle assessment (LCA) to compare environmental impacts of residential rain gardens constructed in the Shepherd's Creek watershed of Cincinnati, Ohio to those from a typical detain and treat system. LCA is an internationally standardized framework for analyzing the potential environmental performance of a product or service by including all stages in its life cycle, including material extraction, manufacturing, use, and disposal. Complementary to the life cycle environmental impact assessment, the life cycle costing approach was adopted to compare the equivalent annual costs of each of these systems. These analyses were supplemented by modeling alternative scenarios to capture the variability in implementing a GI strategy. Our LCA models suggest rain garden costs and impacts are determined by labor requirement; the traditional alternative's impacts are determined largely by the efficiency of wastewater treatment, while costs are determined by the expense of tunnel construction. Gardens were found to be the favorable option, both financially (similar to 42% cost reduction) and environmentally (62-98% impact reduction). Wastewater utilities may find significant life cycle cost and environmental impact reductions in implementing a rain garden plan. C1 [Vineyard, Donald; Ingwersen, Wesley W.; Xue, Xiaobo; Demeke, Bayou; Shuster, William] US EPA, Natl Risk Management Lab, Cincinnati, OH 45268 USA. [Hawkins, Troy R.] Enviance Inc, Carlsbad, CA 92008 USA. RP Vineyard, D (reprint author), US EPA, Natl Risk Management Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM Donnie.Vineyard@epa.gov NR 74 TC 5 Z9 5 U1 18 U2 84 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2015 VL 51 IS 5 BP 1342 EP 1360 DI 10.1111/1752-1688.12320 PG 19 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CS8WG UT WOS:000362369900013 ER PT J AU Watson, EB Andrews, HM Fischer, A Cencer, M Coiro, L Kelley, S Wigand, C AF Watson, Elizabeth Burke Andrews, Holly M. Fischer, Amy Cencer, Morgan Coiro, Laura Kelley, Sean Wigand, Cathleen TI Growth and photosynthesis responses of two co-occurring marsh grasses to inundation and varied nutrients SO BOTANY LA English DT Article DE eutrophication; salinity; marsh loss; New England; sea level rise ID SEA-LEVEL RISE; ENGLAND SALT-MARSH; ARBUSCULAR MYCORRHIZAL FUNGI; SPARTINA-PATENS; PLANT ZONATION; CAPE-COD; AERENCHYMA FORMATION; METABOLIC-RESPONSES; VEGETATION CHANGE; COASTAL MARSHES AB For tidal marshes of the US Northeast, the late twentieth century decline of Spartina patens (Aiton) Muhl. has been attributed to increased flooding associated with accelerated sea level rise and nitrogen over-enrichment from cultural eutrophication. The objective of this study was to examine the impacts of inundation and nutrient availability on growth, photosynthesis, and interactions of S. patens and Distichlis spicata (L.) Greene, which co-occur and are common marsh species. Plants were grown in a factorial greenhouse experiment, where flow-through seawater was used to simulate semidiurnal tides. Field surveys were additionally conducted to relate plant distributions to environmental conditions. For S. patens grown in monoculture, nutrient additions did not enhance growth for the high inundation treatment. In addition, the combination of high nutrient availability and high inundation adversely affected S. patens tiller density, photosynthetic efficiency, and leaf CO2 uptake. For D. spicata, nutrient additions enhanced growth for both inundation treatments with respect to aboveground biomass and tiller density. For species pairings, S. patens expanded relative to D. spicata under low inundation, low nutrient availability conditions, but declined relative to D. spicata under daily inundation in combination with nutrient amendments. These findings were additionally supported by field data, which indicated that D. spicata was more common than S. patens where nutrient availability was high. These results suggest that S. patens persistence is favored by low nutrient inputs and well-drained conditions, and supports the interpretation that this species is vulnerable to loss where high nutrient loads coincide with accelerated sea level rise. C1 [Watson, Elizabeth Burke; Coiro, Laura; Kelley, Sean; Wigand, Cathleen] US EPA, Atlantic Ecol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI USA. [Andrews, Holly M.] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA. [Fischer, Amy] Arkansas State Univ, Jonesboro, AR USA. [Cencer, Morgan] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA. [Kelley, Sean] Univ Rhode Isl, Dept Nat Resources Sci, Kingston, RI 02881 USA. RP Watson, EB (reprint author), Drexel Univ, Acad Nat Sci, Earth & Environm Sci Dept, Biodivers, Philadelphia, PA 19104 USA. EM elizabeth.b.watson@gmail.com FU US Environmental Protection Agency FX We acknowledge K. Kelly for maintaining the flow-through seawater system, R. Ahlgren for arranging the reverse osmosis system, and the US Fish and Wildlife Service, the Barrington Land Trust, the City of Warwick, and the Nature Conservancy for access to field sites. The Narragansett Bay National Estuarine Research Reserve provided access to the field sites on Prudence Island, loans of field equipment, and logistical and technical support, and we would like to specifically recognize K. Raposa, D. Durant, and R. Weber for their contributions. A. Hanson, R. Johnson, A. Oczkowski, C. Esch, M. Chintala, J. Bishop, and N. Angelo provided field and laboratory assistance. R. McKinney, G. Thursby, and R. Johnson provided helpful input on an earlier version of this manuscript. This report is tracking number ORD-003241 of the US EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division. Although the information in this document has been funded by the US Environmental Protection Agency, it does not necessarily reflect the views of the Agency and no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 74 TC 3 Z9 3 U1 10 U2 57 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 1916-2790 EI 1916-2804 J9 BOTANY JI Botany PD OCT PY 2015 VL 93 IS 10 BP 671 EP 683 DI 10.1139/cjb-2015-0055 PG 13 WC Plant Sciences SC Plant Sciences GA CS3VU UT WOS:000362004100005 ER PT J AU Soller, J Bartrand, T Ravenscroft, J Molina, M Whelan, G Schoen, M Ashbolt, N AF Soller, Jeffrey Bartrand, Timothy Ravenscroft, John Molina, Marirosa Whelan, Gene Schoen, Mary Ashbolt, Nicholas TI Estimated human health risks from recreational exposures to stormwater runoff containing animal faecal material SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Quantitative microbial risk assessment; Recreational water; Human health risk ID SIMULATED RAINFALL EVENTS; ESCHERICHIA-COLI O157-H7; GRASS BUFFER CONDITIONS; DOSE-RESPONSE; WATER-QUALITY; CRYPTOSPORIDIUM-PARVUM; SWINE MANURE; GASTROINTESTINAL ILLNESS; ZOONOTIC TRANSMISSION; DRINKING-WATER AB Scientific evidence supporting recreational water quality benchmarks primarily stems from epidemiological studies conducted at beaches impacted by human fecal sources. Epidemiological studies conducted at locations impacted by non-human faecal sources have provided ambiguous and inconsistent estimates of risk. Quantitative Microbial Risk Assessment (QMRA) is another tool to evaluate potential human health risks from recreational exposures to non-human faecal contamination. The potential risk differential between human and selected non-human faecal sources has been characterized previously for direct deposition of animal feces to water. In this evaluation, we examine the human illness potential from a recreational exposure to freshwater impacted by rainfall-induced runoff containing agricultural animal faecal material. Risks associated with these sources would be at least an order of magnitude lower than the benchmark level of public health protection associated with current US recreational water quality criteria, which are based on contamination from human sewage sources. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Soller, Jeffrey; Schoen, Mary] Soller Environm LLC, Berkeley, CA 94703 USA. [Bartrand, Timothy] Corona Environm Consulting, Bala Cynwyd, PA 19004 USA. [Ravenscroft, John] US EPA, Off Water, Off Sci & Technol, Washington, DC 20460 USA. [Molina, Marirosa; Whelan, Gene] US EPA, Off Res & Dev, Athens, GA 30605 USA. [Ashbolt, Nicholas] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Soller, J (reprint author), Soller Environm LLC, 3022 King St, Berkeley, CA 94703 USA. EM jsoller@sollerenvironmental.com OI Ravenscroft, John/0000-0002-8834-7310 FU U.S. EPA Office of Water, Office of Science and Technology FX The research described in this article was funded by the U.S. EPA Office of Water, Office of Science and Technology. This work has been subject to formal Agency review, but does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. We gratefully acknowledge Gunther Craun, Martha Embrey, Mark Gibson, Jose Sobrinho, Shamima Akhter, Elizabeth Doyle, Sharon Nappier, Grace Robiou, Cindy Roberts, and Susan Petterson for their support, critiques, and review of this work. NR 99 TC 8 Z9 8 U1 6 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD OCT PY 2015 VL 72 BP 21 EP 32 DI 10.1016/j.envsoft.2015.05.018 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA CS2MX UT WOS:000361906400003 ER PT J AU Donner, E Scheckel, K Sekine, R Popelka-Filcoff, RS Bennett, JW Brunetti, G Naidu, R McGrath, SP Lombi, E AF Donner, E. Scheckel, K. Sekine, R. Popelka-Filcoff, R. S. Bennett, J. W. Brunetti, G. Naidu, R. McGrath, S. P. Lombi, E. TI Non-labile silver species in biosolids remain stable throughout 50 years of weathering and ageing SO ENVIRONMENTAL POLLUTION LA English DT Article DE Silver; Biosolids; XANES; Speciation; Isotopic dilution; E-values ID X-RAY-ABSORPTION; GRAM-NEGATIVE BACTERIA; SEWAGE-SLUDGE; WASTE-WATER; ENGINEERED NANOMATERIALS; ENVIRONMENTAL TRANSFORMATIONS; SULFIDE NANOPARTICLES; HEAVY-METALS; SPECIATION; FATE AB Increasing commercial use of nanosilver has focussed attention on the fate of silver (Ag) in the waste-water release pathway. This paper reports the speciation and lability of Ag in archived, stockpiled, and contemporary biosolids from the UK, USA and Australia, and indicates that biosolids Ag concentrations have decreased significantly over recent decades. XANES revealed the importance of reduced-sulfur binding environments for Ag speciation in materials ranging from freshly produced sludge to biosolids weathered under ambient environmental conditions for more than 50 years. Isotopic dilution with Ag-110m showed that Ag was predominantly non-labile in both fresh and aged biosolids (13.7% mean lability), with E-values ranging from 0.3 to 60 mg/kg and 5 mM CaNO3 extractable Ag from 1.2 to 609 mu g/kg (0.002-3.4% of the total Ag). This study indicates that at the time of soil application, biosolids Ag will be predominantly Ag-sulfides and characterised by low isotopic lability. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Donner, E.; Sekine, R.; Brunetti, G.; Naidu, R.; Lombi, E.] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes Campus, SA 5095, Australia. [Donner, E.; Naidu, R.; Lombi, E.] CRC CARE, Salisbury, SA 5106, Australia. [Scheckel, K.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Popelka-Filcoff, R. S.] Flinders Univ S Australia, Sch Chem & Phys Sci, Adelaide, SA 5001, Australia. [Bennett, J. W.] Australian Nucl Sci & Technol Org, Neutron Activat Grp, Lucas Heights, NSW 2234, Australia. [McGrath, S. P.] Rothamsted Res, Harpenden AL5 2JQ, Herts, England. RP Donner, E (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg X, Mawson Lakes Campus, SA 5095, Australia. EM erica.donner@unisa.edu.au RI Donner, Erica/A-4809-2012; McGrath, Steve/B-5127-2008; ID, MRCAT/G-7586-2011; Sekine, Ryo/F-3721-2013; Lombi, Enzo/F-3860-2013 OI Scheckel, Kirk/0000-0001-9326-9241; Popelka-Filcoff, Rachel/0000-0001-6826-6401; Donner, Erica/0000-0001-6465-2233; McGrath, Steve/0000-0003-0952-8947; Sekine, Ryo/0000-0001-9980-0603; Lombi, Enzo/0000-0003-3384-0375 FU Co-operative Research Centre for Contamination Assessment and Remediation of the Environment (CRC-CARE Project) [3.1.7.08/09]; Australian Research Council [FT130101003, FTFT100100337]; AINSE research award [ALNGRA12037P, ALNGRA12138P]; Australian Institute of Nuclear Science and Engineering (AINSE) FX This research was undertaken using beamline ID-10 at the Advanced Photon Source (APS, Argonne, IL, USA, and the XAS beamline at the Australian Synchrotron. Samples were also analysed using the NAA facility at the OPAL Research Reactor, Lucas Heights, Australia. We thank Peter Kappen at the XAS beamline and Attila Stopic and Phillip Brown at the NAA facility for technical support. Financial support was provided by the Co-operative Research Centre for Contamination Assessment and Remediation of the Environment (CRC-CARE Project 3.1.7.08/09) and by the Australian Research Council (FT130101003 and FTFT100100337). NAA analysis was conducted with the assistance of AINSE research awards No. ALNGRA12037P and ALNGRA12138P. Rachel Popelka-Filcoff acknowledges the financial support of the Australian Institute of Nuclear Science and Engineering (AINSE) Research Fellowship. NR 66 TC 5 Z9 5 U1 7 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD OCT PY 2015 VL 205 BP 78 EP 86 DI 10.1016/j.envpol.2015.05.017 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CS8AM UT WOS:000362308100010 PM 26021819 ER PT J AU Li, SB Erickson, RJ Wallis, LK Diamond, SA Hoff, DJ AF Li, Shibin Erickson, Russell J. Wallis, Lindsay K. Diamond, Stephen A. Hoff, Dale J. TI Modeling TiO2 nanoparticle phototoxicity: The importance of chemical concentration, ultraviolet radiation intensity, and time SO ENVIRONMENTAL POLLUTION LA English DT Article DE Nano-TiO2; Phototoxicity; Dosimetry model; Hyalella azteca; Bunsen-Roscoe photochemical law ID TITANIUM-DIOXIDE NANOPARTICLES; DAPHNIA-MAGNA; ZEBRAFISH; TOXICITY; PHOTOCATALYSIS AB As a semiconductor with wide band gap energy, TiO2 nanoparticles (nano-TiO2) are highly photoactive, and recent efforts have demonstrated phototoxicity of nano-TiO2 to aquatic organisms. However, a dosimetry model for the phototoxicity of nanomaterials that incorporates both direct UV and photo-activated chemical toxicity has not yet been developed. In this study, a set of Hyalella azteca acute toxicity bioassays at multiple light intensities and nano-TiO2 concentrations, and with multiple diel light cycles, was conducted to assess how existing phototoxicity models should be adapted to nano-TiO2. These efforts demonstrated (a) adherence to the Bunsen-Roscoe law for the reciprocity of light intensity and time, (b) no evidence of damage repair during dark periods, (c) a lack of proportionality of effects to environmental nano-TiO2 concentrations, and (d) a need to consider the joint effects of nano-TiO2 phototoxicity and direct UV toxicity. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Li, Shibin; Erickson, Russell J.; Wallis, Lindsay K.; Hoff, Dale J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Diamond, Stephen A.] Nanosafe Inc, Blacksburg, VA USA. RP Li, SB (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM li.shibin@epa.gov NR 28 TC 4 Z9 4 U1 7 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD OCT PY 2015 VL 205 BP 327 EP 332 DI 10.1016/j.envpol.2015.06.020 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA CS8AM UT WOS:000362308100037 PM 26123721 ER PT J AU Soucek, DJ Mount, DR Dickinson, A Hockett, JR McEwen, AR AF Soucek, David J. Mount, David R. Dickinson, Amy Hockett, J. Russell McEwen, Abigail R. TI Contrasting effects of chloride on growth, reproduction, and toxicant sensitivity in two genetically distinct strains of Hyalella azteca SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Hyalella azteca; Chloride; Toxicity testing; Nitrate; Genetic strain ID AMPHIPOD POPULATIONS; TOXICITY TESTS; NORTH-AMERICA; WATER; NITRITE; SEDIMENTS; ECOTOXICOLOGY; INVERTEBRATES; CONSERVATION; CRUSTACEA AB The strain of Hyalella azteca (Saussure: Amphipoda) commonly used for aquatic toxicity testing in the United States has been shown to perform poorly in some standardized reconstituted waters frequently used for other test species. In 10-d and 42-d experiments, the growth and reproduction of the US laboratory strain of H. azteca was shown to vary strongly with chloride concentration in the test water, with declining performance observed below 15 mg/L to 20 mg/L. In contrast to the chloride-dependent performance of the US laboratory strain of H. azteca, growth of a genetically distinct strain of H. azteca obtained from an Environment Canada laboratory in Burlington, Ontario, Canada, was not influenced by chloride concentration. In acute toxicity tests with the US laboratory strain of H. azteca, the acute toxicity of sodium nitrate increased with decreasing chloride in a pattern similar not only to that observed for control growth, but also to previous acute toxicity testing with sodium sulfate. Subsequent testing with the Burlington strain showed no significant relationship between chloride concentration and the acute toxicity of sodium nitrate or sodium sulfate. These findings suggest that the chloride-dependent toxicity shown for the US laboratory strain may be an unusual feature of that strain and perhaps not broadly representative of aquatic organisms as a whole. Environ Toxicol Chem 2015;34:2354-2362. (c) 2015 SETAC C1 [Soucek, David J.; Dickinson, Amy; McEwen, Abigail R.] Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Mount, David R.; Hockett, J. Russell] US EPA, Mid Continent Ecol Div, Duluth, MN USA. RP Soucek, DJ (reprint author), Illinois Nat Hist Survey, Champaign, IL 61820 USA. EM soucek@illinois.edu FU Great Lakes Restoration Initiative by way of a Cooperative Ecosystem Studies Unit grant from US Geological Survey, Columbia Environmental Research Center [G12AC20285] FX We thank T.L. Highland and T.J. Norberg-King for their contributions to studies conducted at the US Environmental Protection Agency-Duluth laboratory. Studies conducted at the Illinois Natural History Survey were funded by the Great Lakes Restoration Initiative by way of a Cooperative Ecosystem Studies Unit grant (#G12AC20285) from the US Geological Survey, Columbia Environmental Research Center. M. Hung assisted with experiments conducted at the Illinois Natural History Survey. NR 35 TC 6 Z9 6 U1 3 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2015 VL 34 IS 10 BP 2354 EP 2362 DI 10.1002/etc.3070 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CS6VW UT WOS:000362222200021 PM 26260521 ER PT J AU McFarland, J Zhou, YY Clarke, L Sullivan, P Colman, J Jaglom, WS Colley, M Patel, P Eom, J Kim, SH Kyle, GP Schultz, P Venkatesh, B Haydel, J Mack, C Creason, J AF McFarland, James Zhou, Yuyu Clarke, Leon Sullivan, Patrick Colman, Jesse Jaglom, Wendy S. Colley, Michelle Patel, Pralit Eom, Jiyon Kim, Son H. Kyle, G. Page Schultz, Peter Venkatesh, Boddu Haydel, Juanita Mack, Charlotte Creason, Jared TI Impacts of rising air temperatures and emissions mitigation on electricity demand and supply in the United States: a multi-model comparison (vol 131, pg 111, 2015) SO CLIMATIC CHANGE LA English DT Correction C1 [Zhou, Yuyu; Clarke, Leon; Patel, Pralit; Eom, Jiyon; Kim, Son H.; Kyle, G. Page] PNNL, Joint Global Change Res Inst, College Pk, MD USA. [Jaglom, Wendy S.; Colley, Michelle; Schultz, Peter; Venkatesh, Boddu; Haydel, Juanita; Mack, Charlotte] ICF Int, Fairfax, VA USA. [Sullivan, Patrick; Colman, Jesse] Natl Renewable Energy Lab, Golden, CO USA. [McFarland, James; Creason, Jared] US EPA, Washington, DC 20460 USA. RP McFarland, J (reprint author), US EPA, Washington, DC 20460 USA. EM mcfarland.james@epa.gov NR 1 TC 0 Z9 0 U1 2 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD OCT PY 2015 VL 132 IS 4 BP 739 EP 739 DI 10.1007/s10584-015-1452-9 PG 1 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CS1CC UT WOS:000361799100021 ER PT J AU Li, HW Afshar-Mohajer, N Wu, CY Bonzongo, JCJ Ilacqua, VA Choi, Y Birky, B AF Li, Hsing-Wang Afshar-Mohajer, Nima Wu, Chang-Yu Bonzongo, Jean-Claude J. Ilacqua, Vito A. Choi, Yongsuk Birky, Brian TI Impacts of hazardous air pollutants emitted from phosphate fertilizer production plants on their ambient concentration levels in the Tampa Bay area SO AIR QUALITY ATMOSPHERE AND HEALTH LA English DT Article DE Phosphate fertilizer plant; Hazardous air pollutant; Atmospheric dispersion; Source apportionment; Human exposure ID PARTICULATE MATTER POLLUTION; BALANCE SOURCE APPORTIONMENT; TRACE-ELEMENTS; HEAVY-METALS; UNCERTAINTY; MODEL; INDIA; PM10 AB The concentrations and distribution of hazardous air pollutants (HAPs) metals emitted from four phosphate fertilizer plants in Central Florida, as well as their environmental and health impacts, were investigated. It was hypothesized that the modern control devices employed in the plants would lower the exposure, if any, to an acceptable level. The dominant HAP metals emitted from the stacks of these plants were identified to be Mn, Cr, Ni, and Se. The ambient concentrations at six receptors (Zephyrhills, Plant City, Tampa, Lakeland, Tower Dairy, and Sydney) downwind the plants estimated by AERMOD revealed the maximum ground level concentrations were lower than the European Communities and USEPA standards. Source apportionment estimated by the chemical mass balance (CMB) model indicated that marine (45.5 +/- 17.1 %) and geological (17.3 +/- 10.6 %) were the top two contributors for 26 elements, while the phosphate fertilizer plants contributed only 1.14 +/- 0.55 %. Unexpectedly, the maximum ground-level risks for Cr from plant A (1.3 x 10(-6) +/- 8.4 x 10(-8)) and plant D (1.1 x 10(-6) +/- 6.7 x 10(-8)) were slightly higher than the general guideline of 1 x 10(-6), but they occurred within the facility limit. No other metals approached levels of concern for non-cancer risks. One possible source for Cr emissions from these plants may be stainless steel milling balls used in the production process. Sensitivity analysis of the meteorological data in 2001-2005 showed only 7.7 % variation in the corresponding risk. Overall, phosphate fertilizer plants make minor contribution to the ambient levels of HAP metals compared to other sources for the general population in the Tampa Bay area, although more in-depth investigation into the Cr emissions is recommended. C1 [Li, Hsing-Wang; Afshar-Mohajer, Nima; Wu, Chang-Yu; Bonzongo, Jean-Claude J.; Choi, Yongsuk] Univ Florida, Engn Sch Sustainable Infrastruct & Environm, Dept Environm Engn Sci, Gainesville, FL 32611 USA. [Ilacqua, Vito A.] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA. [Birky, Brian] Florida Ind & Phosphate Res Inst, Bartow, FL USA. [Li, Hsing-Wang] China Steel Corp, New Mat Res & Dev Dept, Environm Bioengn & Chem Anal Sect, Kaohsiung 81233, Taiwan. [Choi, Yongsuk] Seoul Metropolitan Govt, Dept Atmospher Res, Res Inst Publ Hlth & Environm, Gwacheon Si 427070, Gyeonggi Do, South Korea. RP Wu, CY (reprint author), Univ Florida, Engn Sch Sustainable Infrastruct & Environm, Dept Environm Engn Sci, POB 116450, Gainesville, FL 32611 USA. EM cywu@ufl.edu RI Ilacqua, Vito/M-8634-2014 OI Ilacqua, Vito/0000-0002-7547-4281 FU Florida Industrial and Phosphate Research Institute [10-05-070R] FX Authors are grateful to Mr. John Glunn, Mr. Alvaro Linero, and Ms. Melody Lovin from the Florida Department of Environmental Protection for providing the meteorological data and valuable insights. Authors also want to thank Dr. Joseph Patrick Pancras of USEPA and Dr. Noreen Poor from University of South Florida for providing ambient data, and Susan Fairchild from USEPA for providing emission data. Authors are thankful to Mr. Shaun Alverado from University of Florida for assistance in data analysis. Authors acknowledge the financial support from the Florida Industrial and Phosphate Research Institute (Contract No. 10-05-070R). The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 44 TC 1 Z9 1 U1 6 U2 15 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 1873-9318 EI 1873-9326 J9 AIR QUAL ATMOS HLTH JI Air Qual. Atmos. Health PD OCT PY 2015 VL 8 IS 5 BP 453 EP 467 DI 10.1007/s11869-014-0294-3 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA CR6GU UT WOS:000361444000003 ER PT J AU Kaldy, JE Shafer, DJ Ailstock, MS Magoun, AD AF Kaldy, James E. Shafer, Deborah J. Ailstock, M. Stephen Magoun, A. Dale TI Effects of temperature, salinity and seed age on induction of Zostera japonica germination in North America, USA SO AQUATIC BOTANY LA English DT Article DE Zostera japonica; Seed germination; Introduced species ID PARENT-OFFSPRING CONFLICT; GENETIC DIVERSITY; CHESAPEAKE BAY; MARINA L.; EELGRASS; POPULATIONS; PATTERNS; CONSERVATION; RESTORATION; PERSISTENCE AB Seagrasses can colonize unstructured mudflats either through clonal growth or seed germination and survival. Zostera japonica is an introduced seagrass in North America that has rapidly colonized mudflats along the Pacific Coast, leading to active management of the species. Growth and physiology have been evaluated; however, there is little information about the factors influencing seed germination. We examined the effects of storage and induction temperature (10, 15, 20 degrees C) and salinity (0, 10, 20, 30), and storage period (1.5 and 26 months) on germination of seeds of the seagrass Z. japonica collected from Yaquina Bay, Oregon, USA. Seed germination at 15 and 20 degrees C was 1.24 times higher than at 10 degrees C. Cumulative seed germination at salinity 0 during the first 28 days was 6.5 times greater than at a salinity of 10; similarly, initial seed germination at a salinity of 10 was 7.3 times greater than that observed for salinity 20 and 30. The proportion of germinated seeds collected in 2011 and stored for 26 months was 1.24 times greater than seeds collected in 2013 that were stored for only 6 weeks. Overall average germination rates were 21.6% and 17.1% for 2011 and 2013, respectively. Our experimental results indicate that salinity had a much stronger control over Z. japonica germination than temperature, and the long storage period suggests that Z. japonica is capable of developing a persistent seed bank. We hypothesize that Z. japonica uses seasonal variations in temperature and salinity to avoid competition between generations favoring germination under conditions that are not optimal for the growth of mature plants. Published by Elsevier B.V. C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA. [Shafer, Deborah J.] Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ailstock, M. Stephen] Anne Arundel Community Coll, Arnold, MD 21012 USA. [Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA. RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA. EM Kaldy.Jim@epa.gov NR 59 TC 3 Z9 3 U1 11 U2 74 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 EI 1879-1522 J9 AQUAT BOT JI Aquat. Bot. PD OCT PY 2015 VL 126 BP 73 EP 79 DI 10.1016/j.aquabot.2015.06.006 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA CR3VM UT WOS:000361261200010 ER PT J AU Talkington, C Filcher, RC Ruie, FA AF Talkington, Clark Filcher, Raymond C. Ruie, Felicia A. TI Addressing barriers to global deployment of best practices to reduce methane emissions from coal mines SO CARBON MANAGEMENT LA English DT Article DE coal mine methane; coal mines; ventilation air methane; methane recovery and use; global methane initiative; United Nations Economic Commission for Europe; Group of Experts on Coal Mine Methane; Songzao Coal and Electricity Company; best practices AB Low energy prices coupled with a lack of carbon financing options have led to shuttering many emission-reducing projects located around the world at gassy coal mines. In late 2013, the Global Methane Initiative (GMI) Coal Subcommittee organized a panel of experts to discuss issues related to investment in coal mine methane (CMM) and ventilation air methane (VAM) emission reduction. The consensus of the panel is that the precipitous fall in Clean Development Mechanism (CDM) carbon prices from the 2011 high of 15 to the 2013 low of (sic)0.50 has had a severe impact on project development and maintenance. Nevertheless, the CDM process demonstrated that carbon financing works, and there are hopeful signs that regional and national markets may provide incentives for renewed CMM and VAM project development. The GMI Coal Subcommittee actively seeks solutions to the challenges facing CMM and VAM emission reduction projects and offers support to its stakeholders through meetings, publications and training. C1 [Talkington, Clark] Adv Resources Int Inc, Arlington, VA 22203 USA. [Filcher, Raymond C.] Raven Ridge Resources Inc, Grand Junction, CO 81505 USA. [Ruie, Felicia A.] United States Environm Protect Agcy, Climate Change Div, Non Program Branch CO2, Washington, DC 20460 USA. RP Talkington, C (reprint author), Adv Resources Int Inc, 4501 Fairfax Dr,Suite 910, Arlington, VA 22203 USA. EM pilcher@RavenRidge.com; ruiz.felicia@epa.gov NR 8 TC 0 Z9 0 U1 2 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1758-3004 EI 1758-3012 J9 CARBON MANAG JI Carbon Manag. PD OCT-DEC PY 2015 VL 5 IS 5-6 BP 587 EP 594 PG 8 WC Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA CR5YE UT WOS:000361419500012 ER PT J AU Vance, L Eason, T Cabezas, H AF Vance, Leisha Eason, Tarsha Cabezas, Heriberto TI Energy sustainability: consumption, efficiency, and environmental impact SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Energy consumption; Environmental impact; Efficiency; Sustainability ID IPAT; PERSPECTIVE; COUNTRIES AB One of the critical challenges in achieving sustainability is finding a way to meet the energy consumption needs of a growing population in the face of increasing economic prosperity and finite resources. According to ecological footprint computations, the global resource consumption began exceeding planetary supply in 1977 and by 2030, global energy demand, population, and gross domestic product are projected to greatly increase over 1977 levels. With the aim of finding sustainable energy solutions, we present a simple yet rigorous procedure for assessing and counterbalancing the relationship between energy demand, environmental impact, population, GDP, and energy efficiency. Our analyses indicated that infeasible increases in energy efficiency (over 100 %) would be required by 2030 to return to 1977 environmental impact levels and annual reductions (2 and 3 %) in energy demand resulted in physical, yet impractical requirements; hence, a combination of policy and technology approaches is needed to tackle this critical challenge. This work emphasizes the difficulty in moving toward energy sustainability and helps to frame possible solutions useful for policy and management. C1 [Vance, Leisha; Eason, Tarsha; Cabezas, Heriberto] US EPA, Off Res & Dev, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Eason, T (reprint author), US EPA, Off Res & Dev, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM leisha75@hotmail.com; eason.tarsha@epa.gov; cabezas.heriberto@epa.gov NR 47 TC 2 Z9 3 U1 0 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD OCT PY 2015 VL 17 IS 7 SI SI BP 1781 EP 1792 DI 10.1007/s10098-015-0932-y PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA CR5OO UT WOS:000361392800006 ER PT J AU Yelverton, TLB Holder, AL Pavlovic, J AF Yelverton, Tiffany L. B. Holder, Amara L. Pavlovic, Jelica TI Emissions removal efficiency from diesel gensets using aftermarket PM controls SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Diesel genset; Emissions factors; PM control ID PARTICULATE MATTER EMISSIONS; AEROSOL LIGHT-ABSORPTION; BLACK CARBON; AETHALOMETER DATA; ENGINES; EXHAUST; NANOPARTICLES; SPECTROMETER; INSTRUMENT; PARTICLES AB Diesel particulate matter (PM) has been associated with adverse health effects in humans and is classified as a human carcinogen. Additionally, the strongly light absorbing fraction, black carbon (BC), has been identified as an important climate forcer. For these reasons, the effectiveness of aftermarket controls on reducing PM and BC from three stationary diesel gensets (230, 400, and 600 kW) of varying engine displacement (from 8.8 to 27 L) and physical size was investigated. Uncontrolled emissions were compared with emissions controlled with a passive (P-DPF) and active diesel particulate filter (A-DPF) and a diesel oxidation catalyst (DOC). Overall, the DPFs resulted in significant PM mass removal (similar to 80-99 %), while the DOC resulted in statistically insignificant reductions (similar to 0-25 %). Both BC and elemental carbon (EC) removal followed a similar trend, but EC/PM ratios varied from 0 to 0.79 over all test conditions, indicating changes in PM composition with the addition of aftermarket controls or changes in load. Further, the single scattering albedo of PM was slightly decreased from the DPFs compared to the uncontrolled case. Particle number concentrations were also significantly reduced when using DPFs, with a greater than 97 % reduction in particle concentrations with the P-DPF and greater than 82 % reduction with the A-DPF. The DOC exhibited much lower particle reductions, reducing the particle concentration by only 5-35 %, depending upon the genset or load. These results demonstrate that while DPFs are effective at reducing PM and BC emissions, the particle characteristics are altered from those of uncontrolled emissions. C1 [Yelverton, Tiffany L. B.; Holder, Amara L.] US EPA, Off Res & Dev, APTB, Air Pollut Prevent & Control Div,Natl Risk Manage, Res Triangle Pk, NC 27711 USA. [Pavlovic, Jelica] Commiss European Communities, Joint Res Ctr, Inst Energy & Transport, Sustainable Transport Unit, I-21020 Ispra, Italy. RP Yelverton, TLB (reprint author), US EPA, Off Res & Dev, APTB, Air Pollut Prevent & Control Div,Natl Risk Manage, 109 TW Alexander Dr,E-365, Res Triangle Pk, NC 27711 USA. EM yelverton.tiffany@epa.gov NR 40 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD OCT PY 2015 VL 17 IS 7 SI SI BP 1861 EP 1871 DI 10.1007/s10098-015-0900-6 PG 11 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA CR5OO UT WOS:000361392800012 ER PT J AU Baig, RBN Leazer, J Varma, RS AF Baig, R. B. Nasir Leazer, John Varma, Rajender S. TI Magnetically separable Fe3O4@DOPA-Pd: a heterogeneous catalyst for aqueous Heck reaction SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Magnetic separation; Magnetite; Dopamine; Heck reaction ID GREEN CHEMISTRY; PALLADIUM; ALLYLATION; OXIDATION; ACETATES; CHITOSAN; FUTURE; MEDIA AB Magnetically separable Fe3O4@DOPA-Pd catalyst has been synthesized via anchoring of palladium over dopamine-coated magnetite via co-ordinate interaction and the catalyst is utilized for expeditious Heck coupling in aqueous media. Magnetically separable Fe3O4@DOPA-Pd catalyst has been synthesized via anchoring of palladium over dopamine-coated magnetite and the catalyst is utilized for expeditious Heck coupling in aqueous media. [GRAPHICS] . C1 [Baig, R. B. Nasir; Leazer, John; Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU Post-graduate Research Program at the National Risk Management Research Laboratory FX R. B. Nasir Baig was supported by the Post-graduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 25 TC 0 Z9 0 U1 2 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD OCT PY 2015 VL 17 IS 7 SI SI BP 2073 EP 2077 DI 10.1007/s10098-015-0914-0 PG 5 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA CR5OO UT WOS:000361392800028 ER PT J AU Salih, HH Wang, LX Patel, V Namboodiri, V Rajagopalan, K AF Salih, Hafiz H. Wang, Lixia Patel, Vinod Namboodiri, Vasudevan Rajagopalan, Kishore TI The utilization of forward osmosis for coal tailings dewatering SO MINERALS ENGINEERING LA English DT Article DE Forward osmosis; Dewatering; Slurry; Coal tailings; Membrane ID MEMBRANES AB The feasibility of dewatering coal tailings slurry by forward osmosis (FO) membrane process was investigated in this research. A prototype cell was designed and used for the dewatering tests. A cellulosic FO membrane (Hydration Technology Innovations, LLC, Albany, OR) was used for the dewatering studies due to its high fouling resistance. Representative samples of coal tailings slurry were collected from the thickener outflow at American Coal Company (Galatia, Illinois). Characterization studies were conducted to obtain particle size distribution (PSD), total dissolved solids (TDS) and the solids content of the slurry. The impact of the slurry properties such as solids weight percent, osmotic pressure, and particle size on the dewatering rates was determined. Furthermore, the impact of slurry conditioning by the addition of flocculant and gypsum on the rate and extent of dewatering was also investigated. Dewatering to a total solids content of more than seventy weight percent from an initial solids content of approximately thirty percent was achieved in all cases. The dewatering rate and extent were found to be a function of particle size, particle shape, TDS content, and mixing. The membrane material was shown to withstand repeated use over a period of thirty trials without deterioration of performance. The results obtained from this research suggest that osmotic dewatering of coal refuse slurry is feasible. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Salih, Hafiz H.; Rajagopalan, Kishore] Univ Illinois, Illinois Sustainable Technol Ctr, Champaign, IL 61820 USA. [Wang, Lixia] Univ Wisconsin, Dept Geosci, Milwaukee, WI 53211 USA. [Patel, Vinod] Univ Illinois, Illinois Sustainable Technol Ctr, Oak Brook, IL 60523 USA. [Namboodiri, Vasudevan] US EPA, Off Res & Dev, Natl Risk Management Lab, Sustainable Technol Div, Cincinnati, OH 45224 USA. RP Rajagopalan, K (reprint author), Univ Illinois, Illinois Sustainable Technol Ctr, 1 Hazelwood Dr, Champaign, IL 61820 USA. EM hsalih@illinois.edu; lixwang@uwm.edu; vapatel@illinois.edu; namboodiri.vasudevan@epamail.epa.gov; nrajagop@illinois.edu FU Illinois Department of Commerce and Economic Opportunity through Office of Coal Development and Illinois Clean Coal Institute FX This work was partially supported by grants made possible by the Illinois Department of Commerce and Economic Opportunity through the Office of Coal Development and the Illinois Clean Coal Institute. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. We thank Dr. Joseph Hirschi of the Illinois Clean Coal Institute for his help with this project. NR 18 TC 2 Z9 3 U1 6 U2 50 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-6875 J9 MINER ENG JI Miner. Eng. PD OCT 1 PY 2015 VL 81 BP 142 EP 148 DI 10.1016/j.mineng.2015.07.024 PG 7 WC Engineering, Chemical; Mineralogy; Mining & Mineral Processing SC Engineering; Mineralogy; Mining & Mineral Processing GA CR3SJ UT WOS:000361253100018 ER PT J AU Smith, LM Wade, CM Case, JL Harwell, LC Straub, KR Summers, JK AF Smith, Lisa M. Wade, Christina M. Case, Jason L. Harwell, Linda C. Straub, Kendra R. Summers, James K. TI Evaluating the Transferability of a US Human Well-Being Index (HWBI) Framework to Native American Populations SO SOCIAL INDICATORS RESEARCH LA English DT Article DE Well-being; Index; Tribal; American Indian Alaska Native populations ID HEALTH DISPARITIES; SERVICES AB A Human Well-Being Index (HWBI) has been developed for the U.S. to help inform and empower decision makers to equitably weigh and integrate human health, socio-economic, environmental and ecological factors to foster sustainability. The integrity of the index structure is designed to be transferable to different U.S. population groups across space, time and demography. This paper presents the applicability and integrity of the HWBI framework using metrics scaled to assess well-being for American Indian Alaska Native (AIAN) and large tribal populations. Potential modifications needed to produce reasonably defensible well-being assessments were identified and HWBIs were calculated for the AIAN population and large tribal groups for the time period covering 2000-2010. Greater than 80 % of the data available for a national AIAN assessment were specific to the target population, while the remaining data were derived from the general U.S. population. Despite the utilization of non-target data, the AIAN well-being signature could still be differentiated from the U.S. HWBI, indicating that the HWBI approach is transferable. As designed, the framework is intended to be used for a variety of spatial scales and demographic groups; however, the degree to which the structure can be utilized is dependent upon the availability and quantity of quality data. C1 [Smith, Lisa M.; Harwell, Linda C.; Summers, James K.] US EPA, Natl Hlth & Environm Effects Lab, Off Res & Dev, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Wade, Christina M.; Case, Jason L.; Straub, Kendra R.] Univ W Florida, Pensacola, FL 32514 USA. RP Smith, LM (reprint author), US EPA, Natl Hlth & Environm Effects Lab, Off Res & Dev, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM smith.lisam@epa.gov; cmw49@students.uwf.edu; jasonlcase87@gmail.com; harwell.linda@epa.gov; straub.kendra@nps.gov; summers.kevin@epa.gov NR 53 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0303-8300 EI 1573-0921 J9 SOC INDIC RES JI Soc. Indic. Res. PD OCT PY 2015 VL 124 IS 1 BP 157 EP 182 DI 10.1007/s11205-014-0775-7 PG 26 WC Social Sciences, Interdisciplinary; Sociology SC Social Sciences - Other Topics; Sociology GA CR6UH UT WOS:000361482700009 ER PT J AU Liu, XY Guo, ZS Krebs, KA Stinson, RA Nardin, JA Pope, RH Roache, NF AF Liu, Xiaoyu Guo, Zhishi Krebs, Kenneth A. Stinson, Rayford A. Nardin, Joshua A. Pope, Robert H. Roache, Nancy F. TI Chamber study of PCB emissions from caulking materials and light ballasts SO CHEMOSPHERE LA English DT Article DE Polychlorinated biphenyls (PCBs); Aroclor; Chamber testing; Source emissions; Caulking materials; Light ballasts ID POLYCHLORINATED-BIPHENYLS; INDOOR AIR; SEALANTS; CONTAMINATION; BUILDINGS AB The emissions of polychlorinated biphenyl (PCB) congeners from thirteen caulk samples were tested in a micro-chamber system. Twelve samples were from PCB-contaminated buildings and one was prepared in the laboratory. Nineteen light ballasts collected from buildings that represent 13 different models from five manufacturers were tested in 53-L environmental chambers. The rates of PCB congener emissions from caulking materials and light ballasts were determined. Several factors that may have affected the emission rates were evaluated. The experimentally determined emission factors showed that, for a given PCB congener, there is a linear correlation between the emission factor and the concentration of the PCB congener in the source. Furthermore, the test results showed that an excellent log-linear correlation exists between the normalized emission factor and the vapor pressure (coefficient of determination, r(2) >= 0.8846). The PCB congener emissions from ballasts at or near room temperature were relatively low with or without electrical load. However, the PCB congener emission rates increased significantly as the temperature increased. The results of this research provide new data and models for ranking the primary sources of PCBs and supports the development and refinement of exposure assessment models for PCBs. Published by Elsevier Ltd. C1 [Liu, Xiaoyu; Guo, Zhishi; Krebs, Kenneth A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Stinson, Rayford A.; Nardin, Joshua A.; Pope, Robert H.; Roache, Nancy F.] ARCADIS US Inc, Durham, NC 27713 USA. RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM liu.xiaoyu@epa.gov NR 30 TC 3 Z9 3 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2015 VL 137 BP 115 EP 121 DI 10.1016/j.chemosphere.2015.05.102 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA CQ8OG UT WOS:000360867100015 PM 26092318 ER PT J AU Wang, C Bi, J Ambros, RB AF Wang, Ce Bi, Jun Ambros, Robert B. TI Development and application of mathematical models to support total maximum daily load for the Taihu Lake's influent rivers, China SO ECOLOGICAL ENGINEERING LA English DT Article DE Taihu Lake; Influent river; Nutrient; TMDL; WASP ID NORTH-CAROLINA; WATER-QUALITY; NEUSE RIVER; IMPLEMENTATION AB The control of nitrogen and phosphorus pollution from the watershed and influent rivers to Taihu Lake became a significant issue of concern to the Chinese government following a large algal bloom in 2007. It is more scientific to make policies on river pollution control based on total maximum daily load (TMDL) development which requires the estimation of allowable maximum pollutant load of the river of interest. "The Twelfth Five-Year Guideline - The overall program on integrated regulation of Taihu Lake Basin" strongly recommends the development of a TMDL analysis for the Zhushan Bay watershed, including three representative influent rivers - the Taigeyunhe, Caoqiaohe and Yincungang Rivers. Dynamic mechanistic models used in developing TMDL predominates over other mathematical approaches mainly because they can simulate the fate and transport of pollutant, link pollution source with water quality response, and evaluates various management scenarios when required data resource are available. In this study, a site-specific empirical model is developed and linked to the Water Quality Analysis Simulation Program (WASP), a general, mechanistic model of water quality. The resulting modeling system considers the essential physical features of the complex Zhushan Bay watershed and quantifies the relationship of in-stream nutrient concentrations and watershed loads. It is used to investigate a set of TMDL load reductions to meet water quality standards. Analysis of the model calibration and validation to long-term observational data shows that the combined model performs satisfactorily for prediction of pollutant fate and evaluation of various modeling scenarios to meet the target TMDL condition. The calculated TMDL reductions can provide a scientific basis for the authority to make water pollution management decisions. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wang, Ce; Bi, Jun] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China. [Ambros, Robert B.] US EPA, New York, NY USA. RP Bi, J (reprint author), Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China. EM jbi@nju.edu.cn RI Wang, Ce/B-2500-2012 OI Wang, Ce/0000-0001-6244-1205 FU Major Science and Technology Program for Water Pollution Control and Treatment [2012ZX07506-004-004]; IOT-Based Environmental Emergency Security System for Nanjing Youth Olympic Games [2012AA063304] FX This research was supported by Major Science and Technology Program for Water Pollution Control and Treatment (2012ZX07506-004-004) and IOT-Based Environmental Emergency Security System for Nanjing Youth Olympic Games (2012AA063304). We gratefully thank the Jiangsu Environmental Monitoring Center, National Meteorological Information Center, National Science and Technology Infrastructure: Data Sharing Infrastructure of Earth System Science (http://nnu.geodata.cn) for providing their monitoring and auxiliary data sets. NR 28 TC 4 Z9 4 U1 11 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 EI 1872-6992 J9 ECOL ENG JI Ecol. Eng. PD OCT PY 2015 VL 83 BP 258 EP 267 DI 10.1016/j.ecoleng.2015.06.036 PG 10 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA CQ7VA UT WOS:000360812000034 ER PT J AU Seco, R Karl, T Guenther, A Hosman, KP Pallardy, SG Gu, LH Geron, C Harley, P Kim, S AF Seco, Roger Karl, Thomas Guenther, Alex Hosman, Kevin P. Pallardy, Stephen G. Gu, Lianhong Geron, Chris Harley, Peter Kim, Saewung TI Ecosystem-scale volatile organic compound fluxes during an extreme drought in a broadleaf temperate forest of the Missouri Ozarks (central USA) SO GLOBAL CHANGE BIOLOGY LA English DT Article DE biogenic emissions; drought; isoprene; isoprene volcano; megan; methanol; monoterpenes; VOC ID REACTION MASS-SPECTROMETRY; WESTERN MEDITERRANEAN BASIN; EDDY COVARIANCE MEASUREMENT; EMISSION RATE VARIABILITY; OXYGENATED VOC EMISSIONS; ISOPRENE EMISSION; QUERCUS-ILEX; MONOTERPENE EMISSIONS; HOLM OAK; ENVIRONMENTAL-FACTORS AB Considerable amounts and varieties of biogenic volatile organic compounds (BVOCs) are exchanged between vegetation and the surrounding air. These BVOCs play key ecological and atmospheric roles that must be adequately represented for accurately modeling the coupled biosphere-atmosphere-climate earth system. One key uncertainty in existing models is the response of BVOC fluxes to an important global change process: drought. We describe the diurnal and seasonal variation in isoprene, monoterpene, and methanol fluxes from a temperate forest ecosystem before, during, and after an extreme 2012 drought event in the Ozark region of the central USA. BVOC fluxes were dominated by isoprene, which attained high emission rates of up to 35.4mgm(-2)h(-1) at midday. Methanol fluxes were characterized by net deposition in the morning, changing to a net emission flux through the rest of the daylight hours. Net flux of CO2 reached its seasonal maximum approximately a month earlier than isoprenoid fluxes, which highlights the differential response of photosynthesis and isoprenoid emissions to progressing drought conditions. Nevertheless, both processes were strongly suppressed under extreme drought, although isoprene fluxes remained relatively high compared to reported fluxes from other ecosystems. Methanol exchange was less affected by drought throughout the season, confirming the complex processes driving biogenic methanol fluxes. The fraction of daytime (7-17h) assimilated carbon released back to the atmosphere combining the three BVOCs measured was 2% of gross primary productivity (GPP) and 4.9% of net ecosystem exchange (NEE) on average for our whole measurement campaign, while exceeding 5% of GPP and 10% of NEE just before the strongest drought phase. The meganv2.1 model correctly predicted diurnal variations in fluxes driven mainly by light and temperature, although further research is needed to address model BVOC fluxes during drought events. C1 [Seco, Roger; Kim, Saewung] Univ Calif Irvine, Dept Earth Syst Sci, Irvine, CA 92697 USA. [Karl, Thomas] Univ Innsbruck, Inst Meteorol & Geophys, A-6020 Innsbruck, Austria. [Guenther, Alex] Pacific NW Natl Lab, Richland, WA 99352 USA. [Guenther, Alex] Washington State Univ, Dept Civil & Environm Engn, Pullman, WA 99164 USA. [Hosman, Kevin P.; Pallardy, Stephen G.] Univ Missouri, Dept Forestry, Columbia, MO 65211 USA. [Gu, Lianhong] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. [Geron, Chris] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Harley, Peter] Natl Ctr Atmospher Res, Div Atmospher Chem, Boulder, CO 80301 USA. RP Seco, R (reprint author), Univ Calif Irvine, Dept Earth Syst Sci, Irvine, CA 92697 USA. EM email@rogerseco.cat RI Seco, Roger/F-7124-2011; Kim, Saewung/E-4089-2012; Karl, Thomas/D-1891-2009; Gu, Lianhong/H-8241-2014 OI Seco, Roger/0000-0002-2078-9956; Karl, Thomas/0000-0003-2869-9426; Gu, Lianhong/0000-0001-5756-8738 FU Fundacion Ramon Areces; EC Seventh Framework Program (Marie Curie Reintegration Program, 'ALP-AIR') [334084]; Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory; U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research Program, Climate and Environmental Sciences Division; U.S. Department of Energy [DE-AC05-00OR22725, DE-FG02-03ER63683]; National Science Foundation FX RS was partly supported by a postdoctoral fellowship awarded by Fundacion Ramon Areces. TK was supported by the EC Seventh Framework Program (Marie Curie Reintegration Program, 'ALP-AIR', grant no. 334084). AG was supported by the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory. Help by Dr. Pawel Misztal with computer programming and fruitful discussions with Dr. Mark Potosnak were greatly appreciated. This study was partly supported by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research Program, Climate and Environmental Sciences Division. ORNL is managed by UT-Battelle, LLC, for the U.S. Department of Energy under contract DE-AC05-00OR22725. U.S. Department of Energy support for the University of Missouri (Grant DE-FG02-03ER63683) is gratefully acknowledged. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. It has been subjected to Agency's administrative review and approved for publication. The National Center for Atmospheric Research is sponsored by the National Science Foundation. NR 136 TC 13 Z9 13 U1 12 U2 70 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1354-1013 EI 1365-2486 J9 GLOBAL CHANGE BIOL JI Glob. Change Biol. PD OCT PY 2015 VL 21 IS 10 BP 3657 EP 3674 DI 10.1111/gcb.12980 PG 18 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CR0FS UT WOS:000360994500009 PM 25980459 ER PT J AU Leibowitz, SG AF Leibowitz, Scott G. TI Geographically Isolated Wetlands: Why We Should Keep the Term SO WETLANDS LA English DT Review DE GIW; Connectivity; Isolation; Rapanos; SWANCC; Waters of the US ID UNITED-STATES; HYDROLOGIC CONNECTIVITY; DEPRESSIONAL WETLANDS; CLASSIFICATION AB Use of the term "isolated wetlands" in the U.S. Supreme Court's SWANCC decision created confusion, since it could imply functional isolation. In response, the term "geographically isolated wetlands" (GIWs) - wetlands surrounded by uplands - was introduced in 2003. A recent article revisits the term, concluding that it is a misnomer that adds to the confusion. Hydrogeomorphic (HGM) type and non-adjacency to jurisdictional waters are suggested as alternatives. To address this issue, I pose two questions: is there a need to identify wetlands surrounded by uplands and what to call them? Regarding the former, there is a legal/regulatory need resulting from the Court's Rapanos decision: to help determine whether such wetlands have a significant nexus with traditional navigable waters. There is also a scientific need to understand how the normal lack of surface water connectivity affects function. Regarding the second question, neither HGM type nor non-adjacency adequately identifies wetlands surrounded by uplands. I contend that "GIW" remains the most informative option. However, the term needs to be applied properly and researchers should emphasize that being surrounded by uplands does not imply hydrological or biological isolation. Further, conclusions from one GIW type should be extrapolated to other GIWs with great care. C1 US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. RP Leibowitz, SG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM leibowitz.scott@epa.gov FU U.S. Environmental Protection Agency FX This paper is an outgrowth, in part, of the "Geographically Isolated Wetlands Research Workshop" that was convened and co-hosted by the U.S. Environmental Protection Agency, Office of Research and Development and the Joseph W. Jones Ecological Research Center that was held in Newton, GA, November 18-21, 2013. I thank the workshop organizers and all participants for stimulating and thought-provoking discussions. Thanks also to James Jawitz, Kay Kirkman, and three anonymous reviewers for comments on this manuscript. I am indebted to Rose Kwok of EPA's Wetlands Division for helping me summarize post-Rapanos guidance and the new Clean Water Rule. I would especially like to acknowledge Dave Mushet for serving as a worthy, but gentlemanly, debate partner. The information in this document has been funded entirely by the U.S. Environmental Protection Agency. This manuscript has been subjected to Agency review and has been approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 35 TC 2 Z9 2 U1 1 U2 16 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD OCT PY 2015 VL 35 IS 5 BP 997 EP 1003 DI 10.1007/s13157-015-0691-x PG 7 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA CR0IQ UT WOS:000361002300015 ER PT J AU Muthusamy, N Sommerville, LJ Moeser, AJ Stumpo, DJ Sannes, P Adler, K Blackshear, PJ Weimer, JM Ghashghaei, HT AF Muthusamy, Nagendran Sommerville, Laura J. Moeser, Adam J. Stumpo, Deborah J. Sannes, Philip Adler, Kenneth Blackshear, Perry J. Weimer, Jill M. Ghashghaei, H. Troy TI MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging SO AGING CELL LA English DT Article DE aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress ID PROTEIN-KINASE-C; ADULT MAMMALIAN BRAIN; NEURAL STEM-CELLS; SUBVENTRICULAR ZONE; CEREBROSPINAL-FLUID; FATTY-ACID; IN-VIVO; AIRWAY; CHOLESTEROL; ASTROCYTES AB Ependymal cells (ECs) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in ECs decline significantly during aging in mice. The longevity of these functions in part requires the expression of the myristoylated alanine-rich protein kinase C substrate (MARCKS). Both the expression levels and subcellular localization of MARCKS in ECs are markedly transformed during aging. Conditional deletion of MARCKS in ECs induces intracellular accumulation of mucins, elevated oxidative stress, and lipid droplet buildup. These alterations are concomitant with precocious disruption of ependymal barrier function, which results in the elevation of reactive astrocytes, microglia, and macrophages in the interstitial brain tissue of young mutant mice. Interestingly, similar alterations are observed during normal aging in ECs and the forebrain interstitium. Our findings constitute a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. C1 [Muthusamy, Nagendran; Sommerville, Laura J.; Sannes, Philip; Adler, Kenneth; Ghashghaei, H. Troy] North Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27607 USA. [Moeser, Adam J.] North Carolina State Univ, Coll Vet Med, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA. [Moeser, Adam J.; Sannes, Philip; Ghashghaei, H. Troy] North Carolina State Univ, Coll Vet Med, Ctr Comparat Med & Translat Res, Raleigh, NC 27607 USA. [Stumpo, Deborah J.; Blackshear, Perry J.] Natl Inst Environm Hlth Sci, Lab Signal Transduct, Durham, NC 27709 USA. [Weimer, Jill M.] Univ S Dakota, Sanford Sch Med, Sanford Res, Childrens Hlth Res & Dept Pediat, Sioux Falls, SD 57104 USA. [Ghashghaei, H. Troy] N Carolina State Univ, Genet Program, Raleigh, NC 27607 USA. RP Ghashghaei, HT (reprint author), North Carolina State Univ, Dept Mol Biomed Sci, 1060 William Moore Dr, Raleigh, NC 27607 USA. EM Troy_Ghashghaei@ncsu.edu FU National Institutes of Health [R01NS062182]; American Federation for Aging Research; NCSU; NIH [P20GM103620]; Sanford Research FX This work is supported by the National Institutes of Health grant (H.T.G., R01NS062182), by a grant from the American Federation for Aging Research (H.T.G.), and by institutional funds (NCSU, H.T.G.; Sanford Research, JMW) and an Institutional Development Award from the NIH (P20GM103620, JMW). NR 46 TC 3 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1474-9718 EI 1474-9726 J9 AGING CELL JI Aging Cell PD OCT PY 2015 VL 14 IS 5 BP 764 EP 773 DI 10.1111/acel.12354 PG 10 WC Cell Biology; Geriatrics & Gerontology SC Cell Biology; Geriatrics & Gerontology GA CQ7FA UT WOS:000360767200006 PM 26010231 ER PT J AU Eckley, CS Luxton, TP McKernan, JL Goetz, J Goulet, J AF Eckley, C. S. Luxton, T. P. McKernan, J. L. Goetz, J. Goulet, J. TI Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR SO APPLIED GEOCHEMISTRY LA English DT Article DE Mercury mine; Mercury methylation; Reservoir; Water-level; Sediment ID DESULFOBULBUS-PROPIONICUS 1PR3; DISSOLVED ORGANIC-CARBON; 2 OREGON RESERVOIRS; METHYL MERCURY; HYDROELECTRIC RESERVOIRS; NORTHERN WISCONSIN; AQUATIC ENVIRONMENT; REDUCING BACTERIA; PURE CULTURES; YELLOW PERCH AB Mercury (Hg) is a pollutant of global concern due to its ability to accumulate as methylmercury (MeHg) in biota. Mercury is methylated by anaerobic microorganisms such as sulfate reducing bacteria (SRB) in water and sediment. Throughout North America, reservoirs tend to have elevated methylmercury (MeHg) concentrations compared to natural lakes and rivers. This impact is most pronounced in newly created reservoirs where methylation is fueled by the decomposition of flooded organic material, which can release Hg and enhance microbial activity. Much less is known about the longer-term water-level management impacts on Hg cycling in older reservoirs. The objective of our study was to understand the role of on-going water-level fluctuations on sediment MeHg concentrations and sulfur speciation within a reservoir 75 years after initial impoundment. The study was performed at the Cottage Grove Reservoir located 15 km downstream of the historical Black Butte Hg mine. For 8 months each year, the water level is lowered resulting in roughly half of the reservoir's sediment being exposed to the atmosphere. Water samples from the inflow, water-column, outflow, and sediment were collected seasonally over a year for total-Hg, MeHg, and several ancillary parameters. The results showed that conditions in the reservoir were favorable to methylation with a much higher % MeHg observed in the outflowing water (34%) compared to the inflow (7%) during the late-summer. An anoxic hypolimnion did not develop in the reservoir indicating that methylation was predominantly occurring in the sediments. In the sediments subjected to seasonal inundation, MeHg production was highest in the top 2 cm of the sediments and declined with depth. The seasonally inundated sediments also had significantly higher methylation activity than the permanently inundated area of the reservoir. Oxidizing conditions in the sediments during periods of exposure to air resulted in an increase in sulfate concentrations which likely stimulated SRB methylation following the raising of the water levels. In contrast, the sulfur in the permanently inundated sediments was all in a reduced form (sulfide) and sulfate remained below detection throughout the year. Overall, our results indicate that reservoir water level fluctuations can affect sediment redox conditions and enhance MeHg production. This process can result in a continued elevation of MeHg concentrations in older reservoirs after the initial impact of landscape flooding has subsided. Published by Elsevier Ltd. C1 [Eckley, C. S.; Goulet, J.] US EPA, Seattle, WA 98101 USA. [Luxton, T. P.; McKernan, J. L.; Goetz, J.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Eckley, CS (reprint author), US EPA, Reg 10,1200 6th Ave, Seattle, WA 98101 USA. EM eckley.chris@epa.gov FU National Risk Management Research Laboratory of U.S. Environmental Protection Agency (Office of Research and Development) FX This research was funded in part by the National Risk Management Research Laboratory of U.S. Environmental Protection Agency (Office of Research and Development). NR 77 TC 5 Z9 5 U1 8 U2 42 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0883-2927 J9 APPL GEOCHEM JI Appl. Geochem. PD OCT PY 2015 VL 61 BP 284 EP 293 DI 10.1016/j.apgeochem.2015.06.011 PG 10 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA CQ5OG UT WOS:000360654200025 ER PT J AU Ruskin, KJ Hodgman, TP Etterson, MA Olsen, BJ AF Ruskin, Katharine J. Hodgman, Thomas P. Etterson, Matthew A. Olsen, Brian J. TI Divergent oviposition preferences of sister species are not driven by nest survival: the evidence for neutrality SO BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY LA English DT Article DE Non-adaptive; Neutral evolution; Oviposition preference; Nest site selection; Speciation; Sympatry; Saltmarsh sparrow; Nelson's sparrow ID SHARP-TAILED SPARROWS; BREEDING-HABITAT SELECTION; SITE SELECTION; PREDATION RISK; ECOLOGICAL TRAP; NEW-ENGLAND; SPECIATION; SUCCESS; CHOICE; MICROCLIMATE AB Both adaptive and neutral trait evolution can contribute to divergence, but the relative contributions of the two remain unclear. Oviposition preference, a trait that has been demonstrated to contribute to divergence among populations, is often presumed to be an adaptive trait. Few studies explicitly test this assumption, however, and several researchers have demonstrated non-adaptive oviposition preferences in wildlife populations. In this study, we test whether adaptive divergence can explain current differences in the oviposition preferences of two sister species. In 2012 and 2013, we conducted a demographic study of sympatrically breeding populations of two sparrow species (Ammodramus caudacutus and Ammodramus nelsoni) and measured vegetation characteristics at nest and non-nest points. We found evidence for oviposition preference in both species and significant differences between the species' preferences. The vegetation characteristics that vary between species did not predict nest survival or offspring production, however. Our results provide an example of oviposition preference at a population level that appears non-adaptive as measured by productivity. We discuss other mechanisms by which oviposition preference can be adaptive, and make a case for the role of neutral evolution in shaping the oviposition preferences of these species. If divergence in oviposition preference is at least periodically neutral, as we hypothesize, such differences could provide fodder for future adaptation or reproductive isolation among populations. C1 [Ruskin, Katharine J.; Olsen, Brian J.] Univ Maine, Climate Change Inst, Sch Biol & Ecol, Orono, ME 04469 USA. [Hodgman, Thomas P.] Maine Dept Inland Fisheries & Wildlife, Bird Grp, Bangor, ME 04401 USA. [Etterson, Matthew A.] US Environm Protect Agcy, Mid Continent Ecol Div, Duluth, MN 55804 USA. RP Ruskin, KJ (reprint author), Univ Maine, Climate Change Inst, Sch Biol & Ecol, 200 Clapp Greenhouse, Orono, ME 04469 USA. EM Katharine.ruskin@maine.edu OI Olsen, Brian/0000-0001-5608-2779 FU Competitive State Wildlife Grant [U2-5-R-1]; National Science Foundation [DEB-1340008] FX This work was funded by a Competitive State Wildlife Grant (# U2-5-R-1) via Federal Aid in Sportfish and Wildlife Restoration to the states of Maryland, Delaware, Connecticut, and Maine and the National Science Foundation (Grant # DEB-1340008). Logistical support was generously provided by the Maine Department of Inland Fisheries and Wildlife and the staff of the Rachel Carson National Wildlife Refuge in Wells, Maine. In particular, we would like to thank K.M. O'Brien, K. Schwaab, and W. Feurt. Finally, thank you to the two anonymous reviewers for their detailed, thoughtful comments that greatly improved this work. NR 67 TC 2 Z9 2 U1 3 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-5443 EI 1432-0762 J9 BEHAV ECOL SOCIOBIOL JI Behav. Ecol. Sociobiol. PD OCT PY 2015 VL 69 IS 10 BP 1639 EP 1647 DI 10.1007/s00265-015-1975-0 PG 9 WC Behavioral Sciences; Ecology; Zoology SC Behavioral Sciences; Environmental Sciences & Ecology; Zoology GA CQ8GT UT WOS:000360845600008 ER PT J AU Roehrig, EE Lao-Davila, DA Wolfe, AL AF Roehrig, Erin E. Lao-Davila, Daniel A. Wolfe, Amy L. TI Serpentinization history of the Rio Guanajibo serpentinite body, Puerto Rico SO JOURNAL OF SOUTH AMERICAN EARTH SCIENCES LA English DT Article DE Veins; Ultramafic; Antigorite; Chrysotile; Serpentine; Lizardite ID DEFORMATION HISTORIES; TECTONIC SIGNIFICANCE; LITHOSPHERIC MANTLE; CRYSTAL-STRUCTURE; GREATER ANTILLES; MIDOCEAN RIDGES; CARIBBEAN PLATE; ORTHO-PYROXENE; FIBROUS VEINS; OCEANIC-CRUST AB The Rio Guanajibo serpentinite body (RGSB) near Mayaguez, Puerto Rico, is part of an ophiolite melange thrust in an oceanic convergent zone. The aim of this study was to characterize the extent and chronology of serpentinization within this peridotite mass. Mineralogy, microstructures, and veining episodes within the RGSB were characterized using optical microscopy, x-ray diffraction (XRD), scanning electron microscopy (SEM), and structural analyses. This study identified, for the first time, all three serpentine polymorphs (i.e., antigorite, chrysotile, lizardite) in serpentinite samples collected from Puerto Rico. Lizardite, the initial serpentine mineral formed from widespread hydration of olivine, was found throughout serpentinite samples. Chrysotile was the most abundant polymorph observed in sheared serpentinite samples, consistent with conditions favoring low fluid to rock ratios, supersaturation and abundant porosity. Antigorite was observed as a replacement texture in serpentinites that were not exposed to greenschist fades metamorphic conditions, and were frequently found in veins with a shear component. The results indicate that metamorphic conditions do not exclusively dictate polymorph formation. The mineralogy and textures observed within the different vein generations reflect the formation conditions, and deformational mechanisms, that occurred during the serpentinization process; six veining episodes (V1 - V6) were identified and grouped into four stages of serpentinization. Stage one (V1 and V2 type veins) represents the earliest stages of serpentinization and was characterized by microscopic fracture networks that formed as a result of cracking during the initial hydration of olivine under low water/rock ratios. During stage two (V3 and V4 type veins), fibrous crack - seal veins formed to accommodate continued volume expansion, via incremental fracture openings, caused by continued hydration of olivine. The ascension of serpentinite into the upper lithosphere was inferred to occur during Stage three; V5 type veins are associated with this stage. Textures and vein morphologies, representing supersaturated conditions and a decrease in temperature, were observed. Stage 4 (V6 type veins) was characterized by shear deformation features, which formed as a result of thrusting associated with the emplacement of the RGSB or Late Eocene transpression and fault reactivation along the Caribbean plate boundary. (c) 2015 Elsevier Ltd. All rights reserved. C1 [Roehrig, Erin E.; Lao-Davila, Daniel A.] Oklahoma State Univ, Boone Pickens Sch Geol, Stillwater, OK 74078 USA. [Wolfe, Amy L.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74820 USA. RP Lao-Davila, DA (reprint author), Oklahoma State Univ, Boone Pickens Sch Geol, 105 Noble Res Ctr, Stillwater, OK 74078 USA. EM erin.roehrig@okstate.edu; daniel.lao_davila@okstate.edu; Wolfe.Amy@epamail.epa.gov NR 114 TC 1 Z9 1 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0895-9811 J9 J S AM EARTH SCI JI J. South Am. Earth Sci. PD OCT PY 2015 VL 62 BP 195 EP 217 DI 10.1016/j.jsames.2015.06.004 PG 23 WC Geosciences, Multidisciplinary SC Geology GA CN5IF UT WOS:000358462300015 ER PT J AU Pancras, JP Norris, GA Landis, MS Kovalcik, KD McGee, JK Kamal, AS AF Pancras, Joseph Patrick Norris, Gary A. Landis, Matthew S. Kovalcik, Kasey D. McGee, John K. Kamal, Ali S. TI Application of ICP-OES for evaluating energy extraction and production wastewater discharge impacts on surface waters in Western Pennsylvania SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Conventional and unconventional oil and natural gas wastewaters; Electric power generating stations wastewaters; Hydraulic fracturing; Public drinking water intakes; Inorganic elemental composition ID DISINFECTION BY-PRODUCTS; NATURAL-GAS EXTRACTION; MARCELLUS SHALE; DRINKING-WATER; QUALITY; PLANTS; WELLS AB Oil and gas extraction and coal-fired electrical power generating stations produce wastewaters that are treated and discharged to rivers in Western Pennsylvania with public drinking water system (PDWS) intakes. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to quantify inorganic species in wastewater and river samples using a method based on EPA Method 200.7 rev4.4. A total of 53 emission lines from 30 elements (Al, As, B, Ba, Ca, Cd, Ce, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Se, Si, Sn, Sr, Ti, Tl, V, and Zn) were investigated. Samples were prepared by microwave-assisted acid digestion using a mixture of 2% HNO3 and 0.5% HCl. Lower interferences and better detection characteristics resulted in selection of alternative wavelengths for Al, As, Sb, Mg, Mo, and Na. Radial view measurements offered accurate determinations of Al, Ba, K, Li, Na, and Sr in high-brine samples. Spike recovery studies and analyses of reference materials showed 80-105% recoveries for most analytes. This method was used to quantify species in samples with high to low brine concentrations with method detection limits a factor of 2 below the maximum contaminant limit concentrations of national drinking water standards. Elements B, Ca, K, Li, Mg, Na, and Sr were identified as potential tracers for the sources impacting PDWS intakes. Usability of the ICP-OES derived data for factor analytic model applications was also demonstrated. Published by Elsevier B.V. C1 [Pancras, Joseph Patrick] Alion Sci & Technol, Res Triangle Pk, NC 27709 USA. [Norris, Gary A.; Landis, Matthew S.; Kovalcik, Kasey D.; McGee, John K.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Kamal, Ali S.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. RP Norris, GA (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM Norris.gary@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development [EP-D-10-070]; Alion Science and Technology FX The U.S. Environmental Protection Agency through its Office of Research and Development funded, managed, and participated in the research described here under Contract EP-D-10-070 with Alion Science and Technology. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. We thank Carry Croghan, Sania Tong Argao, Roy Fortmann, and Clay Nelson (EPA ORD) for their assistance with the project data quality assurance. We also thank Douglas Beak (EPA ORD NRMRL) for his technical review of this manuscript. NR 32 TC 0 Z9 0 U1 8 U2 68 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 1 PY 2015 VL 529 BP 21 EP 29 DI 10.1016/j.scitotenv.2015.04.011 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CK4XP UT WOS:000356227000003 PM 26005746 ER PT J AU Rhea, L Jarnagin, T Hogan, D Loperfido, JV Shuster, W AF Rhea, Lee Jarnagin, Taylor Hogan, Dianna Loperfido, J. V. Shuster, William TI Effects of urbanization and stormwater control measures on streamflows in the vicinity of Clarksburg, Maryland, USA SO HYDROLOGICAL PROCESSES LA English DT Article DE urbanization; land use; precipitation; discharge; hydrograph; stormwater control measures; before-after control-impact (BACI) design ID LOW-IMPACT; MANAGEMENT-PRACTICES; IMPERVIOUS SURFACES; UNITED-STATES; PRECIPITATION; HYDROLOGY; RAINFALL; TIME; SYSTEMS; WATER AB Understanding the efficacy of revised watershed management methods is important to mitigating the impacts of urbanization on streamflow. We evaluated the influence of land use change, primarily as urbanization, and stormwater control measures on the relationship between precipitation and stream discharge over an 8-year period for five catchments near Clarksburg, Montgomery County, Maryland, USA. A unit-hydrograph model based on a temporal transfer function was employed to account for and standardize temporal variation in rainfall pattern, and properly apportion rainfall to streamflow at different time lags. From these lagged relationships, we quantified a correction to the precipitation time series to achieve a hydrograph that showed good agreement between precipitation and discharge records. Positive corrections appeared to include precipitation events that were of limited areal extent and therefore not captured by our rain gages. Negative corrections were analysed for potential causal relationships. We used mixed-model statistical techniques to isolate different sources of variance as drivers that mediate the rainfall-runoff dynamic before and after management. Seasonal periodicity mediated rainfall-runoff relationships, and land uses (i.e. agriculture, natural lands, wetlands and stormwater control measures) were statistically significant predictors of precipitation apportionment to stream discharge. Our approach is one way to evaluate actual effectiveness of management efforts in the face of complicating circumstances and could be paired with cost data to understand economic efficiency or life cycle aspects of watershed management. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. C1 [Rhea, Lee; Shuster, William] US EPA, Sustainable Environm Branch, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Jarnagin, Taylor] US EPA, Landscape Ecol Branch, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Hogan, Dianna; Loperfido, J. V.] US Geol Survey, Eastern Geog Sci Ctr, Reston, VA 22092 USA. [Loperfido, J. V.] McAdams Co, Durham, NC USA. RP Rhea, L (reprint author), Intermountain Healthcare, 36 South State St, Salt Lake City, UT 84111 USA. EM leekrhea@yahoo.com FU USGS Mendenhall Research Fellowship Program; United States Environmental Protection Agency [DW14921533, DW14921811, DW14922385] FX The authors thank Ed Doheny (U.S. Geological Survey (USGS) Maryland-Delaware-D.C. Water Science Center), Montgomery County Department of Environmental Protection and anonymous reviewers. This work was supported in part by the USGS Mendenhall Research Fellowship Program. The United States Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. The manuscript has been subjected to EPA and USGS review and approved for publication. The streamflow data referenced in this document have been funded in part by the United States Environmental Protection Agency under assistance agreements DW14921533, DW14921811 and DW14922385 to the USGS. Any use of trade, firm or product names is for descriptive purposes only and does not imply endorsement by the US Government. NR 45 TC 1 Z9 2 U1 5 U2 38 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD SEP 30 PY 2015 VL 29 IS 20 BP 4413 EP 4426 DI 10.1002/hyp.10505 PG 14 WC Water Resources SC Water Resources GA CQ7CC UT WOS:000360759400004 ER PT J AU Gandhy, SU Imanirad, P Jin, UH Nair, V Cheng, YT Corton, JC Kim, K Safe, S AF Gandhy, Shruti U. Imanirad, Parisa Jin, Un-Ho Nair, Vijayalekshmi Cheng, Yating Corton, J. Christopher Kim, KyoungHyun Safe, Stephen TI Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC SO ONCOTARGET LA English DT Article DE HCC; Sp proteins; HULC; IncRNAs ID HUMAN HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER CELLS; TUMOR-GROWTH; COLORECTAL-CANCER; DOWN-REGULATION; LIVER-CANCER; PROLIFERATION; INHIBITION; SURVIVAL; MICRORNA-27A AB Specificity protein 1 (Sp1) transcription factor (TF) regulates expression of long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) cells. RNA interference (RNAi) studies showed that among several lncRNAs expressed in HepG2, SNU-449 and SK-Hep-1 cells, highly upregulated in liver cancer (HULC) was regulated not only by Sp1 but also Sp3 and Sp4 in the three cell lines. Knockdown of Sp transcription factors and HULC by RNAi showed that they play important roles in HCC cell proliferation, survival and migration. The relative contribution of Sp1, Sp3, Sp4 and HULC on these responses in HepG2, SNU-449 and SK-Hep-1 cells were cell context-and response-dependent. In the poorly differentiated SK-Hep-1 cells, knockdown of Sp1 or HULC resulted in genomic and morphological changes, indicating that Sp1 and Sp1-regulated HULC are important for maintaining the mesenchymal phenotype in this cell line. Genomic analysis showed an inverse correlation between expression of genes after knockdown of HULC and expression of those genes in liver tumors from patients. The antidiabetic drug metformin down-regulates Sp proteins in pancreatic cancer, and similar results including decreased HULC expression were observed in HepG2, SNU-449 and SK-Hep-1 cells treated with metformin, indicating that metformin and other antineoplastic agents that target Sp proteins may have clinical applications for HCC chemotherapy. C1 [Gandhy, Shruti U.; Safe, Stephen] Texas A&M Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX USA. [Imanirad, Parisa; Nair, Vijayalekshmi; Cheng, Yating; Corton, J. Christopher; Safe, Stephen] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA. [Corton, J. Christopher] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA. [Kim, KyoungHyun] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA. RP Safe, S (reprint author), Texas A&M Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX USA. EM ssafe@cvm.tamu.edu FU National Institutes of Health [P30-ES023512]; Texas AgriLife FX National Institutes of Health (P30-ES023512) and Texas AgriLife. NR 48 TC 3 Z9 4 U1 2 U2 3 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD SEP 22 PY 2015 VL 6 IS 28 BP 26359 EP 26372 DI 10.18632/oncotarget.4560 PG 14 WC Oncology; Cell Biology SC Oncology; Cell Biology GA CT9TS UT WOS:000363160100136 PM 26317792 ER PT J AU Madden, MC AF Madden, Michael C. TI Comparative toxicity and mutagenicity of soy-biodiesel and petroleum-diesel emissions: overview of studies from the US EPA, Research Triangle Park, NC SO INHALATION TOXICOLOGY LA English DT Article DE asthma; cardiovascular; diesel; inhalation; lung; mutagenicity; soy biodiesel; toxicity ID EXHAUST; OZONE; VOLUNTEERS; EXPOSURE AB Biodiesel use as a fuel is increasing globally as an alternate to petroleum sources. To comprehensively assess the effects of the use of biodiesel as an energy source, end stage uses of biodiesel such as the effects of inhalation of combusted products on human health must be incorporated. To date, few reports concerning the toxicological effects of the emissions of combusted biodiesel or blends of biodiesel on surrogates of health effects have been published. The relative toxicity of the combusted biodiesel emissions compared to petroleum diesel emissions with short term exposures is also not well known. To address the paucity of findings on the toxicity of combusted biodiesel emissions, studies were undertaken at the U.S. Environmental Protection Agency laboratories in Research Triangle Park, North Carolina. The studies used a variety of approaches with nonhuman animal models to examine biological responses of the lung and cardiovascular systems induced by acute and repeated exposures to pure biodiesel and biodiesel blended with petroleum diesel. Effects of the emissions on induction of mutations in bacterial test strains and mammalian DNA adducts were also characterized and normalized to engine work load. The emissions were characterized as to the physicochemical composition in order to determine the magnitude of the differences among the emissions utilized in the studies. This article summarizes the major finding of these studies which are contained within this special issue of Inhalation Toxicology. The findings provided in these articles provide information about the toxicity of biodiesel emissions relative to petroleum diesel emissions and which can be utilized in a life cycle analyses of the effects of increased biodiesel usage. C1 [Madden, Michael C.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Madden, MC (reprint author), US EPA, Mail Code 58B,104 Mason Farm Rd, Chapel Hill, NC 27514 USA. EM madden.michael@epa.gov NR 19 TC 2 Z9 2 U1 5 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 511 EP 514 DI 10.3109/08958378.2015.1107153 PG 4 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700001 PM 26514779 ER PT J AU Mutlu, E Nash, DG King, C Krantz, TQ Preston, WT Kooter, IM Higuchi, M DeMarini, D Linak, WP Gilmour, MI AF Mutlu, Esra Nash, David G. King, Charly Krantz, Todd Q. Preston, William T. Kooter, Ingeborg M. Higuchi, Mark DeMarini, David Linak, William P. Gilmour, M. Ian TI Generation and characterization of diesel engine combustion emissions from petroleum diesel and soybean biodiesel fuels and application for inhalation exposure studies SO INHALATION TOXICOLOGY LA English DT Article DE Biodiesel; chemistry; combustion; emissions; health; inhalation; lung; petroleum diesel ID BIOASSAY-DIRECTED FRACTIONATION; EXHAUST PARTICLES; IMMUNE-RESPONSES; AIR-POLLUTION; OIL; CARDIOPULMONARY; MUTAGENICITY; BLEND AB Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the U.S. EPA assessed health effects of biodiesel emissions in rodent inhalation models. Commercially obtained soybean biodiesel (B100) and a 20% blend with petroleum diesel (B20) were compared to pure petroleum diesel (B0). Rats and mice were exposed independently for 4h/day, 5days/week for up to 6weeks. Exposures were controlled by dilution air to obtain low (50 mu g/m(3)), medium (150 mu g/m(3)) and high (500 mu g/m(3)) diesel particulate mass (PM) concentrations, and compared to filtered air. This article provides details on facilities, fuels, operating conditions, emission factors and physico-chemical characteristics of the emissions used for inhalation exposures and in vitro studies. Initial engine exhaust PM concentrations for the B100 fuel (19.7 +/- 0.7mg/m(3)) were 30% lower than those of the B0 fuel (28.0 +/- 1.5mg/m(3)). When emissions were diluted with air to control equivalent PM mass concentrations, B0 exposures had higher CO and slightly lower NO concentrations than B100. Organic/elemental carbon ratios and oxygenated methyl esters and organic acids were higher for the B100 than B0. Both the B0 and B100 fuels produced unimodal-accumulation mode particle-size distributions, with B0 producing lower concentrations of slightly larger particles. Subsequent papers in this series will describe the effects of these atmospheres on cardiopulmonary responses and in vitro genotoxicity studies. C1 [Mutlu, Esra; King, Charly; Krantz, Todd Q.; Higuchi, Mark; DeMarini, David; Gilmour, M. Ian] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Mutlu, Esra] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA. [Nash, David G.; Linak, William P.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Nash, David G.] ORISE, Oak Ridge, TN USA. [Preston, William T.] ARCADIS US Inc, Durham, NC USA. [Kooter, Ingeborg M.] TNO, Dept Appl Environm Chem, Utrecht, Netherlands. RP Gilmour, MI (reprint author), US EPA, NHEERL, EPHD, B105-02, Res Triangle Pk, NC 27711 USA. EM gilmour.ian@epa.gov FU EPA/DOE interagency agreement [DW-89-92298301]; Oak Ridge Institute for Science and Education (ORISE) FX Portions of this work were sponsored under the EPA/DOE interagency agreement DW-89-92298301 with Oak Ridge Institute for Science and Education (ORISE). The authors report no declarations of interest. NR 36 TC 8 Z9 8 U1 5 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 515 EP 532 DI 10.3109/08958378.2015.1076910 PG 18 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700002 PM 26514780 ER PT J AU Gavett, SH Wood, CE Williams, MA Cyphert, JM Boykin, EH Daniels, MJ Copeland, LB King, C Krantz, TQ Richards, JH Andrews, DL Jaskot, RH Gilmour, MI AF Gavett, Stephen H. Wood, Charles E. Williams, Marc A. Cyphert, Jaime M. Boykin, Elizabeth H. Daniels, Mary J. Copeland, Lisa B. King, Charly Krantz, Todd Q. Richards, Judy H. Andrews, Debora L. Jaskot, Richard H. Gilmour, M. Ian TI Soy biodiesel emissions have reduced inflammatory effects compared to diesel emissions in healthy and allergic mice SO INHALATION TOXICOLOGY LA English DT Article DE Airway responsiveness; allergic inflammation; allergic mouse model; diesel emissions; soy biodiesel emissions ID AIRWAY INFLAMMATION; EXHAUST PARTICLES; INHALATION EXPOSURE; OXIDATIVE STRESS; NITROGEN-DIOXIDE; SEVERE ASTHMA; LUNG-DISEASE; RESPONSIVENESS; HYPERRESPONSIVENESS; MACROPHAGES AB Toxicity of exhaust from combustion of petroleum diesel (B0), soy-based biodiesel (B100), or a 20% biodiesel/80% petrodiesel mix (B20) was compared in healthy and house dust mite (HDM)-allergic mice. Fuel emissions were diluted to target fine particulate matter (PM2.5) concentrations of 50, 150, or 500g/m(3). Studies in healthy mice showed greater levels of neutrophils and MIP-2 in bronchoalveolar lavage (BAL) fluid 2h after a single 4-h exposure to B0 compared with mice exposed to B20 or B100. No consistent differences in BAL cells and biochemistry, or hematological parameters, were observed after 5d or 4 weeks of exposure to any of the emissions. Air-exposed HDM-allergic mice had significantly increased responsiveness to methacholine aerosol challenge compared with non-allergic mice. Exposure to any of the emissions for 4 weeks did not further increase responsiveness in either non-allergic or HDM-allergic mice, and few parameters of allergic inflammation in BAL fluid were altered. Lung and nasal pathology were not significantly different among B0-, B20-, or B100-exposed groups. In HDM-allergic mice, exposure to B0, but not B20 or B100, significantly increased resting peribronchiolar lymph node cell proliferation and production of T(H)2 cytokines (IL-4, IL-5, and IL-13) and IL-17 in comparison with air-exposed allergic mice. These results suggest that diesel exhaust at a relatively high concentration (500g/m(3)) can induce inflammation acutely in healthy mice and exacerbate some components of allergic responses, while comparable concentrations of B20 or B100 soy biodiesel fuels did not elicit responses different from those caused by air exposure alone. C1 [Gavett, Stephen H.; Wood, Charles E.; Williams, Marc A.; Boykin, Elizabeth H.; Daniels, Mary J.; Copeland, Lisa B.; King, Charly; Krantz, Todd Q.; Richards, Judy H.; Andrews, Debora L.; Jaskot, Richard H.; Gilmour, M. Ian] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Code B105-02, Res Triangle Pk, NC 27711 USA. [Cyphert, Jaime M.] UNC Sch Med, Curriculum Toxicol, Chapel Hill, NC USA. RP Gavett, SH (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Code B105-02, Res Triangle Pk, NC 27711 USA. EM gavett.stephen@epa.gov FU U.S. EPA/University of North Carolina Toxicology Research Program Training Agreement [CR 933237, 83515201-0] FX The authors report no declarations of interest. J. M. C. was supported by the U.S. EPA/University of North Carolina Toxicology Research Program Training Agreement (CR 933237 and 83515201-0). NR 43 TC 2 Z9 2 U1 3 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 533 EP 544 DI 10.3109/08958378.2015.1054966 PG 12 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700003 PM 26514781 ER PT J AU Bass, VL Schladweiler, MC Nyska, A Thomas, RF Miller, DB Krantz, T King, C Gilmour, MI Ledbetter, AD Richards, JE Kodavanti, UP AF Bass, Virginia L. Schladweiler, Mette C. Nyska, Abraham Thomas, Ronald F. Miller, Desinia B. Krantz, Todd King, Charly Gilmour, M. Ian Ledbetter, Allen D. Richards, Judy E. Kodavanti, Urmila P. TI Comparative cardiopulmonary toxicity of exhausts from soy-based biofuels and diesel in healthy and hypertensive rats SO INHALATION TOXICOLOGY LA English DT Article DE Biodiesel; biomarkers; hypertensive rats; pulmonary toxicity; toxicity ID LONG-TERM EXPOSURE; BROWN-NORWAY RATS; PARTICULATE MATTER; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INHALATION; BIODIESEL; PULMONARY; PARTICLES; FUEL AB Increased use of renewable energy sources raise concerns about health effects of new emissions. We analyzed relative cardiopulmonary health effects of exhausts from (1) 100% soy biofuel (B100), (2) 20% soy biofuel+80% low sulfur petroleum diesel (B20), and (3) 100% petroleum diesel (B0) in rats. Normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats were exposed to these three exhausts at 0, 50, 150 and 500g/m(3), 4h/day for 2 days or 4 weeks (5 days/week). In addition, WKY rats were exposed for 1 day and responses were analyzed 0h, 1 day or 4 days later for time-course assessment. Hematological parameters, in vitro platelet aggregation, bronchoalveolar lavage fluid (BALF) markers of pulmonary injury and inflammation, ex vivo aortic ring constriction, heart and aorta mRNA markers of vasoconstriction, thrombosis and atherogenesis were analyzed. The presence of pigmented macrophages in the lung alveoli was clearly evident with all three exhausts without apparent pathology. Overall, exposure to all three exhausts produced only modest effects in most endpoints analyzed in both strains. BALF -glutamyl transferase (GGT) activity was the most consistent marker and was increased in both strains, primarily with B0 (B0>B100>B20). This increase was associated with only modest increases in BALF neutrophils. Small and very acute increases occurred in aorta mRNA markers of vasoconstriction and thrombosis with B100 but not B0 in WKY rats. Our comparative evaluations show modest cardiovascular and pulmonary effects at low concentrations of all exhausts: B0 causing more pulmonary injury and B100 more acute vascular effects. BALF GGT activity could serve as a sensitive biomarker of inhaled pollutants. C1 [Bass, Virginia L.] Univ N Carolina, Sch Publ Hlth, Environm Sci & Engn, Chapel Hill, NC USA. [Schladweiler, Mette C.; Thomas, Ronald F.; Krantz, Todd; King, Charly; Gilmour, M. Ian; Ledbetter, Allen D.; Richards, Judy E.; Kodavanti, Urmila P.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Consultant Toxicol Pathol, Timrat, Israel. [Miller, Desinia B.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA. RP Kodavanti, UP (reprint author), US EPA, NHEERL, Mail Drop B105-02, Res Triangle Pk, NC 27711 USA. EM kodavanti.urmila@epa.gov OI Bass, Virginia/0000-0001-6219-2448 FU NCBA; US EPA (RT) FX Supported in part by the US EPA SEE Program via Cooperative Agreement between NCBA and US EPA (RT). The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does the mention of trade names of commercial products constitute endorsement or recommendation for use. NR 36 TC 3 Z9 3 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 545 EP 556 DI 10.3109/08958378.2015.1060279 PG 12 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700004 PM 26514782 ER PT J AU Hazari, MS Haykal-Coates, N Winsett, DW King, C Krantz, QT Gilmour, MI Farraj, AK AF Hazari, Mehdi S. Haykal-Coates, Najwa Winsett, Darrell W. King, Charly Krantz, Q. Todd Gilmour, M. Ian Farraj, Aimen K. TI The effects of B0, B20, and B100 soy biodiesel exhaust on aconitine-induced cardiac arrhythmia in spontaneously hypertensive rats SO INHALATION TOXICOLOGY LA English DT Article DE Arrhythmia; biodiesel; electrocardiogram; soy; spontaneously hypertensive ID PARTICULATE AIR-POLLUTION; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; HEART-RATE-VARIABILITY; OXIDATIVE STRESS; ENVIRONMENT INTERACTION; FINE PARTICULATE; DIESEL; EMISSIONS; EXPOSURE; DYSFUNCTION AB Context: Diesel exhaust (DE) has been shown to increase the risk of cardiac arrhythmias. Although biodiesel has been proposed as a safer alternative to diesel, it is still uncertain whether it actually poses less threat.Objective: We hypothesized that exposure to pure or 20% soy biodiesel exhaust (BDE) would cause less sensitivity to aconitine-induced arrhythmia than DE in rats.Methods: Spontaneously hypertensive (SH) rats implanted with radiotelemeters were exposed once or for 5d (4h) to either 50mg/m(3) (low), 150mg/m(3) (medium), or 500mg/m(3) (high) of DE (B0), 20% (B20) or 100% (B100) soy biodiesel exhaust. Arrhythmogenesis was assessed 24h later by continuous infusion of aconitine, an arrhythmogenic drug, while heart rate (HR), and electrocardiogram (ECG) were monitored.Results: Rats exposed once or for 5d to low, medium, or high B0 developed arrhythmia at significantly lower doses of aconitine than controls, whereas rats exposed to B20 were only consistently sensitive after 5d of the high concentration. B100 caused mild arrhythmia sensitivity at the low concentration, only after 5d of exposure at the medium concentration and after either a single or 5d at the high concentration.Discussion and conclusions: These data demonstrate that exposure to B20 causes less sensitivity to arrhythmia than B0 and B100. This diminished effect may be due to lower irritant components such as acrolein and nitrogen oxides. Thus, in terms of cardiac health, B20 may be a safer option than both of the pure forms. C1 [Hazari, Mehdi S.; Haykal-Coates, Najwa; Winsett, Darrell W.; King, Charly; Krantz, Q. Todd; Gilmour, M. Ian; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA. RP Hazari, MS (reprint author), US EPA, Environm Publ Hlth Div, Mail Code B143-01, Res Triangle Pk, NC 27711 USA. EM hazari.mehdi@epa.gov NR 43 TC 3 Z9 3 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 557 EP 563 DI 10.3109/08958378.2015.1054967 PG 7 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700005 PM 26514783 ER PT J AU Farraj, AK Haykal-Coates, N Winsett, DW Gilmour, MI King, C Krantz, QT Richards, J Hazari, MS AF Farraj, A. K. Haykal-Coates, N. Winsett, D. W. Gilmour, M. I. King, C. Krantz, Q. T. Richards, J. Hazari, M. S. TI Comparative electrocardiographic, autonomic and systemic inflammatory responses to soy biodiesel and petroleum diesel emissions in rats SO INHALATION TOXICOLOGY LA English DT Article DE Autonomic; biodiesel; cardiovascular; diesel; electrocardiogram; inflammatory; petroleum; soy ID HEART-RATE-VARIABILITY; PARTICULATE AIR-POLLUTION; FAILURE-PRONE RATS; HYPERTENSIVE-RATS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; EXHAUST INHALATION; FINE PARTICULATE; EXPOSURE; PARTICLES AB Context: Biodiesel fuel represents an alternative to high particulate matter (PM)-emitting petroleum-based diesel fuels, yet uncertainty remains regarding potential biodiesel combustion emission health impacts.Objective: The purpose of this study was to compare cardiovascular responses to pure and blended biodiesel fuel emissions relative to petroleum diesel exhaust (DE).Materials and methods: Spontaneously hypertensive rats were exposed for 4h per day for four days via whole body inhalation to combustion emissions (based on PM concentrations 50, 150 or 500g/m(3) or filtered air) from pure (B100) or blended (B20) soy biodiesel, or to pure petroleum DE (B0). Electrocardiogram (ECG) and heart rate variability (HRV, an index of autonomic balance) were monitored before, during and after exposure while pulmonary and systemic inflammation were assessed one day after the final exposure. ECG and HRV data and inflammatory data were statistically analyzed using a linear mixed model for repeated measures and an analysis of variance, respectively.Results: B100 and B0, but not B20, increased HRV during all exposure days at the highest concentration indicating increased parasympathetic tone. Electrocardiographic data were mixed. B100 and B0, but not B20, caused significant changes in one or more of the following: serum C-reactive protein, total protein, low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol, and blood urea nitrogen (BUN) and plasma angiotensin converting enzyme (ACE) and fibrinogen.Discussion and conclusions: Although responses to emissions from all fuels were mixed and relatively mild, some findings point to a reduced cardiovascular impact of blended biodiesel fuel emissions. C1 [Farraj, A. K.; Haykal-Coates, N.; Winsett, D. W.; Gilmour, M. I.; King, C.; Krantz, Q. T.; Richards, J.; Hazari, M. S.] US EPA, NHEERL, Environm Publ Hlth Div, Res Triangle Pk, NC USA. RP Farraj, AK (reprint author), US EPA, Environm Publ Hlth Div, Mail Code B143-01, Res Triangle Pk, NC 27711 USA. EM farraj.aimen@epa.gov NR 59 TC 3 Z9 3 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 564 EP 575 DI 10.3109/08958378.2015.1057884 PG 12 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700006 PM 26514784 ER PT J AU Ross, JA Nelson, GB Mutlu, E Warren, SH Gilmour, MI DeMarini, DM AF Ross, Jeffrey A. Nelson, Garret B. Mutlu, Esra Warren, Sarah H. Gilmour, M. Ian DeMarini, David M. TI DNA adducts induced by in vitro activation of extracts of diesel and biodiesel exhaust particles SO INHALATION TOXICOLOGY LA English DT Article DE Biodiesel; combustion emissions; complex mixtures; diesel; DNA adducts ID POLYCYCLIC AROMATIC-HYDROCARBONS; A/J MOUSE LUNG; EXPOSURE; 1-NITROPYRENE; MUTAGENICITY; EMISSIONS; ATHEROSCLEROSIS; SENSITIVITY; TISSUES; CYP1A1 AB Context: Biodiesel and biodiesel-blend fuels offer a renewable alternative to petroleum diesel, but few data are available concerning the carcinogenic potential of biodiesel exhausts.Objectives: We compared the formation of covalent DNA adducts by the in vitro metabolic activation of organic extracts of diesel-exhaust particles (DEP) from petroleum diesel and soy biodiesel and correlated DNA adduct levels and mutagenicity in Salmonella TA100.Methods: We examined two different DEP from petroleum diesel (C-DEP and B0), one from soy bean oil biodiesel (B100) and one from combustion of a blend of 20% B100 and 80% B0 (B20) for in vitro DNA adduct-forming potential under oxidative or nitroreductive conditions in the presence of calf thymus DNA as well as in vivo in Salmonella TA100. The modified DNA was hydrolyzed and analyzed by P-32-postlabeling using either butanol extraction or nuclease P1 pre-enrichment.Results: Multiple DNA adducts were produced with chromatographic mobilities consistent with PAH and nitro-PAH adducts. The types and quantities of DNA adducts produced by the two independent petroleum diesel DEP were similar, with both polycyclic aromatic hydrocarbon (PAH)- and nitro-PAH-derived adducts formed. Relative potencies for S9-mediated DNA adduct formation, either per mass of particulate or per MJ(th) energy consumed were B100>B0>B20.Conclusions: Soy biodiesel emissions induced DNA damage in the form of presumptive PAH and nitro-PAH DNA adducts that correlated with mutagenicity in Salmonella. B20 is the soy biodiesel used most commonly in the US, and it produced the lowest DNA adduct-emission factor, approximate to 50% that of petroleum diesel. C1 [Ross, Jeffrey A.; Nelson, Garret B.; Mutlu, Esra; Warren, Sarah H.; Gilmour, M. Ian; DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Mutlu, Esra] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27515 USA. RP Ross, JA (reprint author), US EPA, MD B105-03, Res Triangle Pk, NC 27711 USA. EM ross.jeffrey@epa.gov RI Ross, Jeffrey/E-4782-2010 OI Ross, Jeffrey/0000-0002-7002-4548 FU U.S. Environmental Protection Agency FX The authors are grateful to Mark Higuchi and Suryanarayana Vulimiri for their helpful comments on this manuscript. The information in this document has been funded wholly by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 33 TC 3 Z9 3 U1 2 U2 11 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 576 EP 584 DI 10.3109/08958378.2015.1068892 PG 9 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700007 PM 26514785 ER PT J AU Mutlu, E Warren, SH Matthews, PP King, C Walsh, L Kligerman, AD Schmid, JE Janek, D Kooter, IM Linak, WP Gilmour, MI DeMarini, DM AF Mutlu, Esra Warren, Sarah H. Matthews, Peggy P. King, Charly Walsh, Leon Kligerman, Andrew D. Schmid, Judith E. Janek, Daniel Kooter, Ingeborg M. Linak, William P. Gilmour, M. Ian DeMarini, David M. TI Health effects of soy biodiesel emissions: mutagenicity-emission factors SO INHALATION TOXICOLOGY LA English DT Article DE Combustion emissions; complex mixtures; mutagenicity ID BIOASSAY-DIRECTED FRACTIONATION; PETROLEUM-DIESEL EMISSIONS; EXHAUST PARTICLES; OXIDATIVE STRESS; VEGETABLE-OIL; METHYL-ESTER; INHALATION EXPOSURE; PARTICULATE MATTER; CHEMICAL-ANALYSIS; ENGINE EMISSIONS AB Context: Soy biodiesel is the predominant biodiesel fuel used in the USA, but only a few, frequently conflicting studies have examined the potential health effects of its emissions.Objective: We combusted petroleum diesel (B0) and fuels with increasing percentages of soy methyl esters (B20, B50 and B100) and determined the mutagenicity-emission factors expressed as revertants/megajoule of thermal energy consumed (rev/MJ(th)).Materials and Methods: We combusted each fuel in replicate in a small (4.3-kW) diesel engine without emission controls at a constant load, extracted organics from the particles with dichloromethane, determined the percentage of extractable organic material (EOM), and evaluated these extracts for mutagenicity in 16 strains/S9 combinations of Salmonella.Results: Mutagenic potencies of the EOM did not differ significantly between replicate experiments for B0 and B100 but did for B20 and B50. B0 had the highest rev/MJ(th), and those of B20 and B100 were 50% and approximate to 85% lower, respectively, in strains that detect mutagenicity due to polycyclic aromatic hydrocarbons (PAHs), nitroarenes, aromatic amines or oxidative mutagens. For all strains, the rev/MJ(th) decreased with increasing biodiesel in the fuel. The emission factor for the 16 EPA Priority PAHs correlated strongly (r(2)=0.69) with the mutagenicity-emission factor in strain TA100+S9, which detects PAHs.Conclusions: Under a constant load, soy-biodiesel emissions were 50-85% less mutagenic than those of petroleum diesel. Without additional emission controls, petroleum and biodiesel fuels had mutagenicity-emission factors between those of large utility-scale combustors (e.g. natural gas, coal, or oil) and inefficient open-burning (e.g. residential wood fireplaces). C1 [Mutlu, Esra; Warren, Sarah H.; Matthews, Peggy P.; King, Charly; Walsh, Leon; Kligerman, Andrew D.; Schmid, Judith E.; Gilmour, M. Ian; DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Mutlu, Esra] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA. [Janek, Daniel; Linak, William P.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Kooter, Ingeborg M.] TNO, Dept Appl Environm Chem, Utrecht, Netherlands. RP DeMarini, DM (reprint author), US EPA, B105-03, Res Triangle Pk, NC 27711 USA. EM demarini.david@epa.gov FU Office of Research and Development of the U.S. Environmental Protection Agency, Research Triangle Park, NC FX Funding for this research was provided by the intramural research program of the Office of Research and Development of the U.S. Environmental Protection Agency, Research Triangle Park, NC. NR 37 TC 5 Z9 5 U1 3 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 585 EP 596 DI 10.3109/08958378.2015.1080771 PG 12 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700008 PM 26514786 ER PT J AU Mutlu, E Warren, SH Matthews, PP Schmid, JE Kooter, IM Linak, WP Gilmour, MI DeMarini, DM AF Mutlu, Esra Warren, Sarah H. Matthews, Peggy P. Schmid, Judith E. Kooter, Ingeborg M. Linak, William P. Gilmour, M. Ian DeMarini, David M. TI Health effects of soy-biodiesel emissions: bioassay- directed fractionation for mutagenicity SO INHALATION TOXICOLOGY LA English DT Article DE Complex mixtures; diesel exhaust; mutagenesis; PAHs ID DIESEL EXHAUST PARTICLES AB Context: Soy biodiesel is the predominant biodiesel in the USA, but there is little understanding of the classes of chemicals responsible for the mutagenicity of its emissions.Objective: We determined some of the chemical classes responsible for the mutagenicity of the particulate matter (PM) of the emissions from petroleum diesel (B0) and biodiesel containing increasing concentrations of soy methyl esters (B20, B50, and B100).Materials and methods: We subjected organic extracts of the PM to bioassay-directed fractionation by sequential elution on silica gel with solvents of increasing polarity to produce four fractions per fuel. We injected these onto high performance liquid chromatography to produce 62 sub-fractions per fraction based on chemical polarity and evaluated all fractions and sub-fractions for mutagenicity in Salmonella. We correlated the results with the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs) in the fractions.Results: The mutagenicity-emission factors of the fractions generally decreased with increasing concentrations of soy in the fuel. Despite the different chemical compositions of the fuels, the extractable organics of all four emissions had similar features: approximate to 60% of the mass was nonpolar, non-mutagenic compounds; most of the PAHs were polar; and most of the mutagenicity was due to weakly polar and polar compounds. Some of the mutagenicity of B20 was due to highly polar compounds.Conclusions: The PM from soy biodiesel emissions was less mutagenic than that from petroleum diesel, and this reduction was associated with reduced concentrations of various weakly polar, polar, and highly polar mutagens, including PAHs, aromatic amines, nitroarenes, and oxy-PAHs. C1 [Mutlu, Esra; Warren, Sarah H.; Matthews, Peggy P.; Schmid, Judith E.; Gilmour, M. Ian; DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, B105-03, Res Triangle Pk, NC 27711 USA. [Mutlu, Esra] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA. [Kooter, Ingeborg M.] TNO, Dept Appl Environm Chem, Utrecht, Netherlands. [Linak, William P.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP DeMarini, DM (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, B105-03, Res Triangle Pk, NC 27711 USA. EM demarini.david@epa.gov FU Office of Research and Development of the U.S. Environmental Protection Agency, Research Triangle Park, NC, USA FX Funding for this research was provided by the intramural research program of the Office of Research and Development of the U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. The authors declare that they have no financial interest associated with the subject of this work. NR 12 TC 4 Z9 4 U1 2 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD SEP 19 PY 2015 VL 27 IS 11 BP 597 EP 612 DI 10.3109/08958378.2015.1091054 PG 16 WC Toxicology SC Toxicology GA DD2HG UT WOS:000369742700009 PM 26514787 ER PT J AU Wood, JP Meyer, KM Kelly, TJ Choi, YW Rogers, JV Riggs, KB Willenberg, ZJ AF Wood, Joseph P. Meyer, Kathryn M. Kelly, Thomas J. Choi, Young W. Rogers, James V. Riggs, Karen B. Willenberg, Zachary J. TI Environmental Persistence of Bacillus anthracis and Bacillus subtilis Spores SO PLOS ONE LA English DT Article ID SOLAR UV-RADIATION; GEOBACILLUS-STEAROTHERMOPHILUS SPORES; ULTRAVIOLET-RADIATION; HYDROGEN-PEROXIDE; INACTIVATION; RESISTANCE; LIGHT; SURFACES; SURVIVAL; AGENTS AB There is a lack of data for how the viability of biological agents may degrade over time in different environments. In this study, experiments were conducted to determine the persistence of Bacillus anthracis and Bacillus subtilis spores on outdoor materials with and without exposure to simulated sunlight, using ultraviolet (UV)-A/B radiation. Spores were inoculated onto glass, wood, concrete, and topsoil and recovered after periods of 2, 14, 28, and 56 days. Recovery and inactivation kinetics for the two species were assessed for each surface material and UV exposure condition. Results suggest that with exposure to UV, decay of spore viability for both Bacillus species occurs in two phases, with an initial rapid decay, followed by a slower inactivation period. The exception was with topsoil, in which there was minimal loss of spore viability in soil over 56 days, with or without UV exposure. The greatest loss in viable spore recovery occurred on glass with UV exposure, with nearly a four log(10) reduction after just two days. In most cases, B. subtilis had a slower rate of decay than B. anthracis, although less B. subtilis was recovered initially. C1 [Wood, Joseph P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Meyer, Kathryn M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Kelly, Thomas J.; Choi, Young W.; Rogers, James V.; Riggs, Karen B.; Willenberg, Zachary J.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Wood, JP (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. EM wood.joe@epa.gov OI Wood, Joseph/0000-0001-6316-9418 FU Battelle Memorial Institute [GS23F001L-3]; Oak Ridge Institute for Science and Education FX The US EPA funded Battelle Memorial Institute to perform this work via contract GS23F001L-3. Kathryn Meyer was funded as a postdoc through the Oak Ridge Institute for Science and Education. Joseph Wood of the EPA was the sponsor and technical director of the study, and was involved in the study design, data analysis, decision to publish, and preparation of manuscript. NR 39 TC 3 Z9 3 U1 5 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 15 PY 2015 VL 10 IS 9 AR e0138083 DI 10.1371/journal.pone.0138083 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CR8LR UT WOS:000361604400048 PM 26372011 ER PT J AU Chowdhury, I Mansukhani, ND Guiney, LM Hersam, MC Bouchard, D AF Chowdhury, Indranil Mansukhani, Nikhita D. Guiney, Linda M. Hersam, Mark C. Bouchard, Dermont TI Aggregation and Stability of Reduced Graphene Oxide: Complex Roles of Divalent Cations, pH, and Natural Organic Matter SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TIO2-GRAPHENE NANOCOMPOSITES; AQUATIC ENVIRONMENT; POROUS-MEDIA; HUMIC-ACID; REDUCTION; DEPOSITION; TRANSPORT; WATER; TRANSFORMATION; NANOMATERIALS AB The aggregation and stability of graphene oxide (GO) and three successively reduced GO (rGO) nanomaterials were investigated. Reduced GO species were partially reduced GO (rGO-1h), intermediately reduced GO (rGO-2h), and fully reduced GO (rGO-5h). Specifically, influence of pH, ionic strength, ion valence, and presence of natural organic matter (NOM) were studied. Results show that stability of GO in water decreases with successive reduction of functional groups, with pH having the greatest influence on rGO stability. Stability is also dependent on ion valence and the concentration of surface functional groups. While pH did not noticeably affect stability of GO in the presence of 10 mM NaCl, adding 0.1 mM CaCl2 reduced stability of GO with increased pH. This is due to adsorption of Ca2+ ions on the surface functional groups of GO which reduces the surface charge of GO. As the concentration of rGO functional groups decreased, so did the influence of Ca2+ ions on rGO stability. Critical coagulation concentrations (CCC) of GO, rGO-1h, and rGO-2h were determined to be similar to 200 mM, 35 mM, and 30 mM NaCl, respectively. In the presence of CaCl2, CCC values of GO and rGO are quite similar, however. Long-term studies show that a significant amount of rGO-1h and rGO-2h remain stable in Call's Creek surface water, while effluent wastewater readily destabilizes rGO. In the presence NOM and divalent cations (Ca2+, Mg2+), GO aggregates settle from suspension due to GO functional group bridging with NOM and divalent ions. However, rGO-1h and rGO-2h remain suspended due to their lower functional group concentration and resultant reduced NOM-divalent cation bridging. Overall, pH, divalent cations, and NOM can play complex roles in the fate of rGO and GO. C1 [Chowdhury, Indranil] Washington State Univ, Dept Civil & Environm Engn, Pullman, WA 99164 USA. [Mansukhani, Nikhita D.; Guiney, Linda M.; Hersam, Mark C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. [Mansukhani, Nikhita D.; Guiney, Linda M.; Hersam, Mark C.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA. [Mansukhani, Nikhita D.; Guiney, Linda M.; Hersam, Mark C.] Northwestern Univ, Dept Med, Evanston, IL 60208 USA. [Bouchard, Dermont] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA. RP Chowdhury, I (reprint author), Washington State Univ, Dept Civil & Environm Engn, Pullman, WA 99164 USA. EM indranil.chowdhury@wsu.edu; Bouchard.Dermont@epa.gov RI Mansukhani, Nikhita/H-2328-2016; Hersam, Mark/B-6739-2009 OI Mansukhani, Nikhita/0000-0001-6002-0132; FU National Research Council (NRC) Research Associateship Award at EPA; University of California Center for the Environmental Implications of Nanotechnology (NSF-EPA) [DBI-1266377] FX Funding was provided for Indranil Chowdhury by a National Research Council (NRC) Research Associateship Award at EPA. Additional funding was provided by the University of California Center for the Environmental Implications of Nanotechnology (NSF-EPA under Cooperative Agreement # DBI-1266377). This paper has been reviewed in accordance with the USEPA's peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 38 TC 26 Z9 26 U1 28 U2 132 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 15 PY 2015 VL 49 IS 18 BP 10886 EP 10893 DI 10.1021/acs.est.5b01866 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CR5WT UT WOS:000361415800016 PM 26280799 ER PT J AU Yang, GX Best, EPH AF Yang, Guoxiang Best, Elly P. H. TI Spatial optimization of watershed management practices for nitrogen load reduction using a modeling-optimization framework SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Best management practices; Nitrogen-loading; Wetland restoration; Buffer strips; Multi-objective optimization; Genetic algorithm; Modeling-optimization ID AGRICULTURAL WATERSHEDS; BUFFERS; METAANALYSIS; POLLUTION; WETLANDS; COST AB Best management practices (BMPs) can be used effectively to reduce nutrient loads transported from non-point sources to receiving water bodies. However, methodologies of BMP selection and placement in a cost-effective way are needed to assist watershed management planners and stakeholders. We developed a novel modeling-optimization framework that can be used to find cost-effective solutions of BMP placement to attain nutrient load reduction targets. This was accomplished by integrating a GIS-based BMP siting method, a WQM-TMDL-N modeling approach to estimate total nitrogen (TN) loading, and a multi-objective optimization algorithm. Wetland restoration and buffer strip implementation were the two BMP categories used to explore the performance of this framework, both differing greatly in complexity of spatial analysis for site identification. Minimizing TN load and BMP cost were the two objective functions for the optimization process. The performance of this framework was demonstrated in the Tippecanoe River watershed, Indiana, USA. Optimized scenario-based load reduction indicated that the wetland subset selected by the minimum scenario had the greatest N removal efficiency. Buffer strips were more effective for load removal than wetlands. The optimized solutions provided a range of trade-offs between the two objective functions for both BMPs. This framework can be expanded conveniently to a regional scale because the NHDPlus catchment serves as its spatial computational unit. The present study. demonstrated the potential of this framework to find cost-effective solutions to meet a water quality target, such as a 20% TN load reduction, under different conditions. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Yang, Guoxiang] US EPA, ORISE, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Best, Elly P. H.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Yang, GX (reprint author), US Geol Survey, CNTS, Richmond, VA 23228 USA. EM gavin.yangme@gmail.com; elly.best@gmail.com FU ORISE Grant - U.S. EPA/ORD Safe and Sustainable Water Resources Program [92298301] FX This research was supported by ORISE Grant no 92298301, funded by the U.S. EPA/ORD Safe and Sustainable Water Resources Program. NR 26 TC 5 Z9 5 U1 7 U2 50 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD SEP 15 PY 2015 VL 161 BP 252 EP 260 DI 10.1016/j.jenvman.2015.06.052 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CR3WP UT WOS:000361264100029 PM 26188990 ER PT J AU Scown, MW Thoms, MC De Jager, NR AF Scown, Murray W. Thoms, Martin C. De Jager, Nathan R. TI Measuring floodplain spatial patterns using continuous surface metrics at multiple scales SO GEOMORPHOLOGY LA English DT Article DE Floodplain; Spatial pattern; Surface metrics; Scale ID DIGITAL ELEVATION MODELS; BISCAYNE NATIONAL-PARK; LANDSCAPE PATTERN; FRACTAL DIMENSION; RIVER ECOSYSTEMS; TERRAIN ANALYSIS; GEOSTATISTICAL FRAMEWORK; UPPER MISSISSIPPI; SPECIES-RICHNESS; AIRBORNE LIDAR AB Interactions between fluvial processes and floodplain ecosystems occur upon a floodplain surface that is often physically complex. Spatial patterns in floodplain topography have only recently been quantified over multiple scales, and discrepancies exist in how floodplain surfaces are perceived to be spatially organised. We measured spatial patterns in floodplain topography for pool 9 of the Upper Mississippi River, USA, using moving window analyses of eight surface metrics applied to a 1 x 1 m(2) DEM over multiple scales. The metrics used were Range, SD, Skewness, Kurtosis, CV, SDCURV, Rugosity, and Vol:Area, and window sizes ranged from 10 to 1000 m in radius. Surface metric values were highly variable across the floodplain and revealed a high degree of spatial organisation in floodplain topography. Moran's I correlograms fit to the landscape of each metric at each window size revealed that patchiness existed at nearly all window sizes, but the strength and scale of patchiness changed within window size, suggesting that multiple scales of patchiness and patch structure exist in the topography of this floodplain. Scale thresholds in the spatial patterns were observed, particularly between the 50 and 100 m window sizes for all surface metrics and between the 500 and 750 m window sizes for most metrics. These threshold scales are similar to 15-20% and 150% of the main channel width (1-2% and 10-15% of the floodplain width), respectively. These thresholds may be related to structuring processes operating across distinct scale ranges. By coupling surface metrics, multi-scale analyses, and correlograms, quantifying floodplain topographic complexity is possible in ways that should assist in clarifying how floodplain ecosystems are structured. (C) 2015 Elsevier B.V. All rights reserved. C1 [Scown, Murray W.; Thoms, Martin C.] Univ New England, Riverine Landscapes Res Lab, Armidale, NSW 2350, Australia. [De Jager, Nathan R.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. RP Scown, MW (reprint author), US EPA, MS 587,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM mscown2@myune.edu.au OI De Jager, Nathan/0000-0002-6649-4125; Thoms, Martin/0000-0002-8074-0476; Scown, Murray/0000-0003-0663-7937 FU University of New England; U.S.G.S. Upper Midwest Environmental Sciences Center FX The authors wish to thank Greg Pasternack, Richard Marston, and two anonymous reviewers, whose comments on earlier versions were invaluable in improving this manuscript. We also acknowledge support from the University of New England and the U.S.G.S. Upper Midwest Environmental Sciences Center, without which this research would not have been possible. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 114 TC 3 Z9 3 U1 8 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X EI 1872-695X J9 GEOMORPHOLOGY JI Geomorphology PD SEP 15 PY 2015 VL 245 BP 87 EP 101 DI 10.1016/j.geomorph.2015.05.026 PG 15 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA CQ3OF UT WOS:000360511200008 ER PT J AU Sasso, AF Schlosser, PM AF Sasso, A. F. Schlosser, P. M. TI An evaluation of in vivo models for toxicokinetics of hexavalent chromium in the stomach SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Toxicokinetics; Hexavalent chromium; Gastrointestinal tract; Dose response ID DRINKING-WATER; PHYSIOLOGICAL-PARAMETERS; PHARMACOKINETIC MODEL; HUMANS; RATS; REDUCTION; EXPOSURE; MICE; CARCINOGENICITY; HYPOCHLORHYDRIA AB Hexavalent chromium (Cr6) is a drinking water contaminant that has been detected in most of the water systems throughout the United States. In 2-year drinking water bioassays, the National Toxicology Program (NTP) found clear evidence of carcinogenic activity in male and female rats and mice. Because reduction of Cr6 to trivalent chromium (Cr3) is an important detoxifying step in the gastrointestinal (GI) tract prior to systemic absorption, models have been developed to estimate the extent of reduction in humans and animals. The objective of this work was to use a revised model of ex vivo Cr6 reduction kinetics in gastric juice to analyze the potential reduction kinetics under in vivo conditions for mice, rats and humans. A published physiologically-based pharmacokinetic (PBPK) model was adapted to incorporate the new reduction model. This paper focuses on the toxicokinetics of Cr6 in the stomach compartment, where most of the extracellular Cr6 reduction is believed to occur in humans. Within the range of doses administered by the NTP bioassays, neither the original nor revised models predict saturation of stomach reducing capacity to occur in vivo if applying default parameters. However, both models still indicate that mice exhibit the lowest extent of reduction in the stomach, meaning that a higher percentage of the Cr6 dose may escape stomach reduction in that species. Similarly, both models predict that humans exhibit the highest extent of reduction at low doses. Published by Elsevier Inc. C1 [Sasso, A. F.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Sasso, AF (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 1200 Penn Ave NW,Mail Code 8601P, Washington, DC 20460 USA. EM sasso.alan@epa.gov; schlosser.paul@epa.gov OI Schlosser, Paul/0000-0002-9699-9108 NR 34 TC 4 Z9 4 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD SEP 15 PY 2015 VL 287 IS 3 BP 293 EP 298 DI 10.1016/j.taap.2015.06.016 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CQ2IG UT WOS:000360422800013 PM 26123277 ER PT J AU Harding, LW Adolf, JE Mallonee, ME Miller, WD Gallegos, CL Perry, ES Johnson, JM Sellner, KG Paerl, HW AF Harding, L. W., Jr. Adolf, J. E. Mallonee, M. E. Miller, W. D. Gallegos, C. L. Perry, E. S. Johnson, J. M. Sellner, K. G. Paerl, H. W. TI Climate effects on phytoplankton floral composition in Chesapeake Bay SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE phytoplankton; taxonomic composition; HPLC; algal photopigments; cell counts; climate change; hydrologic forcing ID PERFORMANCE LIQUID-CHROMATOGRAPHY; SUBMERSED AQUATIC VEGETATION; PARTIALLY STRATIFIED ESTUARY; SAN-FRANCISCO BAY; LONG-TERM TRENDS; WATER-QUALITY; COASTAL EUTROPHICATION; PRIMARY PRODUCTIVITY; COMMUNITY-STRUCTURE; NORTH-CAROLINA AB Long-term data on floral composition of phytoplankton are presented to document seasonal and inter-annual variability in Chesapeake Bay related to climate effects on hydrology. Source data consist of the abundances of major taxonomic groups of phytoplankton derived from algal photopigments (1995-2004) and cell counts (1985-2007). Algal photopigments were measured by high-performance liquid chromatography (HPLC) and analyzed using the software CHEMTAX to determine the proportions of chlorophyll-a (chl-a) in major taxonomic groups. Cell counts determined microscopically provided species identifications, enumeration, and dimensions used to obtain proportions of cell volume (CV), plasma volume (PV), and carbon (C) in the same taxonomic groups. We drew upon these two independent data sets to take advantage of the unique strengths of each method, using comparable quantitative measures to express floral composition for the main stem bay. Spatial and temporal variability of floral composition was quantified using data aggregated by season, year, and salinity zone. Both time-series were sufficiently long to encompass the drought flood cycle with commensurate effects on inputs of freshwater and solutes. Diatoms emerged as the predominant taxonomic group, with significant contributions by dinoflagellates, cryptophytes, and cyanobacteria, depending on salinity zone and season. Our analyses revealed increased abundance of diatoms in wet years compared to long-term average (LTA) or dry years. Results are presented in the context of long-term nutrient over-enrichment of the bay, punctuated by inter-annual variability of freshwater flow that strongly affects nutrient loading, chl-a, and floral composition. Statistical analyses generated flow-adjusted diatom abundance and showed significant trends late in the time series, suggesting current and future decreases of nutrient inputs may lead to a reduction of the proportion of biomass comprised by diatoms in an increasingly diverse flora. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Harding, L. W., Jr.] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA 90095 USA. [Adolf, J. E.] Univ Hawaii, Dept Marine Sci, Hilo, HI 96720 USA. [Mallonee, M. E.] US EPA, Interstate Commiss Potomac River Basin, Chesapeake Bay Program Off, Annapolis, MD 21403 USA. [Miller, W. D.] US Naval Res Lab, Washington, DC 20375 USA. [Gallegos, C. L.] Smithsonian Environm Res Ctr, Edgewater, MD 21037 USA. [Sellner, K. G.] Chesapeake Res Consortium Inc, Edgewater, MD 21037 USA. [Paerl, H. W.] Univ North Carolina Chapel Hill, Inst Marine Sci, Morehead City, NC 28557 USA. RP Harding, LW (reprint author), Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA 90095 USA. EM lharding@atmos.ucla.edu OI Harding, Jr., Lawrence W./0000-0002-4824-5205; Gallegos, Charles/0000-0001-5112-0166; Miller, W. David/0000-0002-4940-5987 FU NSF Small Grants for Environmental Research (SGER); NSF Biological Oceanography Program; NSF Land Margin Ecosystem Research Program; NASA SeaWiFS; SIMBIOS Program; NASA/EPA STAR Program; NOAA Chesapeake Bay Program Office; MD Departments of Health and Mental Hygiene and Natural Resources; EPA STAR Program; North Carolina Department of Environment and Natural Resources; ModMon; FerryMon Project FX We acknowledge support from several sources, including the EPA CBP monitoring program that provided water-quality and cell-counts data, and NSF LMER, NSF Biocomplexity, NSF Microbial Observatory, NSF Small Grants for Environmental Research (SGER), and EPA/NASA-STAR Atlantic Coast Environmental Indicators Consortium (ACE-INC) projects that enabled the collection of samples for algal photopigments. LWH, JEA, MEM and WDM were supported by NSF Biological Oceanography Program, NSF Land Margin Ecosystem Research Program, NASA SeaWiFS and SIMBIOS Programs, NASA/EPA STAR Program, and NOAA Chesapeake Bay Program Office. KGS was supported by the MD Departments of Health and Mental Hygiene and Natural Resources. HWP was supported by EPA STAR Program, NSF Biological Oceanography Program, and the North Carolina Department of Environment and Natural Resources, ModMon and FerryMon Projects. NR 108 TC 4 Z9 5 U1 2 U2 39 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 EI 1096-0015 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD SEP 5 PY 2015 VL 162 SI SI BP 53 EP 68 DI 10.1016/j.ecss.2014.12.030 PG 16 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA CQ7HX UT WOS:000360774700007 ER PT J AU Powers, CM Mills, KA Morris, SA Klaessig, F Gaheen, S Lewinski, N Hendren, CO AF Powers, Christina M. Mills, Karmann A. Morris, Stephanie A. Klaessig, Fred Gaheen, Sharon Lewinski, Nastassja Hendren, Christine Ogilvie TI Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials SO BEILSTEIN JOURNAL OF NANOTECHNOLOGY LA English DT Article DE curation; informatics; nanoinformatics; nanomaterials; workflows AB There is a critical opportunity in the field of nanoscience to compare and integrate information across diverse fields of study through informatics (i.e., nanoinformatics). This paper is one in a series of articles on the data curation process in nanoinformatics (nanocuration). Other articles in this series discuss key aspects of nanocuration (temporal metadata, data completeness, database integration), while the focus of this article is on the nanocuration workflow, or the process of identifying, inputting, and reviewing nanomaterial data in a data repository. In particular, the article discusses: 1) the rationale and importance of a defined workflow in nanocuration, 2) the influence of organizational goals or purpose on the workflow, 3) established workflow practices in other fields, 4) current workflow practices in nanocuration, 5) key challenges for workflows in emerging fields like nanomaterials, 6) examples to make these challenges more tangible, and 7) recommendations to address the identified challenges. Throughout the article, there is an emphasis on illustrating key concepts and current practices in the field. Data on current practices in the field are from a group of stakeholders active in nanocuration. In general, the development of workflows for nanocuration is nascent, with few individuals formally trained in data curation or utilizing available nanocuration resources (e.g., ISA-TAB-Nano). Additional emphasis on the potential benefits of cultivating nanomaterial data via nanocuration processes (e.g., capability to analyze data from across research groups) and providing nanocuration resources (e.g., training) will likely prove crucial for the wider application of nanocuration workflows in the scientific community. C1 [Powers, Christina M.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Mills, Karmann A.] RTI Int, Res Triangle Pk, NC 27709 USA. [Morris, Stephanie A.] NCI, Off Canc Nanotechnol Res, NIH, Bethesda, MD 20892 USA. [Klaessig, Fred] Penn Bio Nano Syst LLC, Doylestown, PA 18901 USA. [Gaheen, Sharon] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA. [Lewinski, Nastassja] Virginia Commonwealth Univ, Dept Chem & Life Sci Engn, Richmond, VA 23284 USA. [Hendren, Christine Ogilvie] Duke Univ, Ctr Environm Implicat NanoTechnol CEINT, Durham, NC 27708 USA. RP Hendren, CO (reprint author), Duke Univ, Ctr Environm Implicat NanoTechnol CEINT, POB 90287,121 Hudson Hall, Durham, NC 27708 USA. EM christine.hendren@duke.edu RI Lewinski, Nastassja/E-2993-2012 OI Lewinski, Nastassja/0000-0002-9335-9949 FU National Science Foundation (NSF); Environmental Protection Agency (EPA) under NSF Cooperative Agreement [DBI-1266252, EF-0830093]; National Institutes of Health (NIH) [HHSN268201000022C] FX Authors are grateful to Mervi Heiskanen (NIH/NCI) for her time and technical expertise to provide tools that supported collaboration on this article. C.O.H. would like to gratefully acknowledge the Center for the Environmental Implications of NanoTechnology (CEINT) funding from National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement DBI-1266252 and EF-0830093. RTI International, developers of the Nanomaterial Registry, would like to thank the National Institutes of Health (NIH) for funding their work, under contract HHSN268201000022C. The views, opinions, and content in this article are those of the authors and do not necessarily represent the views, opinions, or policies of their respective employers or organizations Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. government. NR 10 TC 2 Z9 2 U1 4 U2 10 PU BEILSTEIN-INSTITUT PI FRANKFURT AM MAIN PA TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY SN 2190-4286 J9 BEILSTEIN J NANOTECH JI Beilstein J. Nanotechnol. PD SEP 4 PY 2015 VL 6 BP 1860 EP 1871 DI 10.3762/bjnano.6.189 PG 12 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA CQ4VF UT WOS:000360602000001 PM 26425437 ER PT J AU Marten, AL Kopits, EA Griffiths, CW Newbold, SC Wolverton, A AF Marten, Alex L. Kopits, Elizabeth A. Griffiths, Charles W. Newbold, Stephen C. Wolverton, Ann TI Incremental CH4 and N2O mitigation benefits consistent with the U.S. Government's SC-CO2 estimates (vol 15, pg 272, 2015) SO CLIMATE POLICY LA English DT Correction C1 [Marten, Alex L.; Kopits, Elizabeth A.; Griffiths, Charles W.; Newbold, Stephen C.; Wolverton, Ann] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA. RP Marten, AL (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave, Washington, DC 20460 USA. EM marten.alex@epa.gov NR 1 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1469-3062 EI 1752-7457 J9 CLIM POLICY JI Clim. Policy PD SEP 3 PY 2015 VL 15 IS 5 BP 678 EP 679 DI 10.1080/14693062.2015.1070550 PG 2 WC Environmental Studies; Public Administration SC Environmental Sciences & Ecology; Public Administration GA CO7OW UT WOS:000359350700008 ER PT J AU Wright, DR Underhill, LG Keene, M Knight, AT AF Wright, Dale R. Underhill, Les G. Keene, Matt Knight, Andrew T. TI Understanding the Motivations and Satisfactions of Volunteers to Improve the Effectiveness of Citizen Science Programs SO SOCIETY & NATURAL RESOURCES LA English DT Article DE atlas data; conservation psychology; Environmental Volunteer Functions Inventory (EVFI); evaluation; participatory research; South Africa ID CONSERVATION OUTCOMES; FUNCTIONAL-APPROACH; SOUTH-AFRICA; BIODIVERSITY; PROJECT; IMPLEMENTATION; KNOWLEDGE; NETWORK; TOOLS; GAP AB Citizen science is a useful approach for conducting scientific research; however, an understanding of the motivations, satisfactions, and other aspects of volunteers' psychology is essential for conservation scientists wishing to mobilize this resource. We tested psychometric instruments for assessing the motivations, satisfactions, and advocacy role of volunteers with the Second Southern African Bird Atlas Project (SABAP2). Data were collected through stakeholder and volunteer surveys, and focus groups with the program's management. Qualitative and quantitative data analysis included content analysis, statistical tests of internal consistency, and factor analysis. An inventory, the Environmental Volunteer Functions Inventory (EVFI), was tested for assessing volunteer motivations along with scales for assessing volunteer satisfaction and level of advocacy. These scales revealed that volunteers in SABAP2 are satisfied with the program and exhibit behaviors suggesting they act as advocates for the program. Insights and a platform for adaptive management are provided for managers of the social dimensions of citizen science and other conservation programs. C1 [Wright, Dale R.] Univ Cape Town, Percy Fitzpatrick Inst African Ornithol, Dept Biol Sci, ZA-7700 Rondebosch, South Africa. [Underhill, Les G.] Univ Cape Town, Anim Demog Unit, Dept Biol Sci, ZA-7700 Rondebosch, South Africa. [Keene, Matt] US EPA, Evaluat Support Div, Off Policy, Washington, DC 20460 USA. [Knight, Andrew T.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Ascot, Berks, England. [Knight, Andrew T.] Nelson Mandela Metropolitan Univ, Dept Bot, Elizabeth, South Africa. RP Wright, DR (reprint author), BirdLife South Africa, 55 Hastings St, ZA-8001 Cape Town, South Africa. EM dalewr@gmail.com OI Underhill, Les/0000-0002-8758-1527 FU Percy FitzPatrick Institute of African Ornithology of the University of Cape Town; University Research Committee of the University of Cape Town; Stellenbosch University; ARC Centre of Excellence in Environmental Decisions at The University of Queensland, Australia; SANBI (South African National Biodiversity Institute) FX DRW acknowledges the financial support of the Percy FitzPatrick Institute of African Ornithology of the University of Cape Town and the assistance of the co-authors of this article for much guidance during this research. LGU acknowledges support from the University Research Committee of the University of Cape Town. ATK acknowledges the financial support of Stellenbosch University, and the support of the ARC Centre of Excellence in Environmental Decisions at The University of Queensland, Australia. The Second Southern African Bird Atlas Project (SABAP2) has largely been funded by SANBI (South African National Biodiversity Institute) and is a partnership between SANBI, Bird Life South Africa, and the Animal Demography Unit, University of Cape Town. NR 58 TC 2 Z9 2 U1 8 U2 86 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0894-1920 EI 1521-0723 J9 SOC NATUR RESOUR JI Soc. Nat. Resour. PD SEP 2 PY 2015 VL 28 IS 9 BP 1013 EP 1029 DI 10.1080/08941920.2015.1054976 PG 17 WC Environmental Studies; Planning & Development; Sociology SC Environmental Sciences & Ecology; Public Administration; Sociology GA CP1MO UT WOS:000359640100006 ER PT J AU Beach, RH Cai, YX Thomson, A Zhang, XS Jones, R McCarl, BA Crimmins, A Martinich, J Cole, J Ohrel, S DeAngelo, B McFarland, J Strzepek, K Boehlert, B AF Beach, Robert H. Cai, Yongxia Thomson, Allison Zhang, Xuesong Jones, Russell McCarl, Bruce A. Crimmins, Allison Martinich, Jeremy Cole, Jefferson Ohrel, Sara DeAngelo, Benjamin McFarland, James Strzepek, Kenneth Boehlert, Brent TI Climate change impacts on US agriculture and forestry: benefits of global climate stabilization SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Article DE climate change impacts; agricultural modeling; forestry modeling; mitigation scenarios; EPIC; MC1; FASOM-GHG ID ATMOSPHERIC CARBON-DIOXIDE; UNITED-STATES; CO2; GROWTH; YIELD; ECOSYSTEMS; WEATHER; MARKETS; CROPS; WATER AB Increasing atmospheric carbon dioxide levels, higher temperatures, altered precipitation patterns, and other climate change impacts have already begun to affect US agriculture and forestry, with impacts expected to become more substantial in the future. There have been numerous studies of climate change impacts on agriculture or forestry, but relatively little research examining the long-term net impacts of a stabilization scenario relative to a case with unabated climate change. We provide an analysis of the potential benefits of global climate change mitigation for US agriculture and forestry through 2100, accounting for landowner decisions regarding land use, crop mix, and management practices. The analytic approach involves a combination of climate models, a crop process model (EPIC), a dynamic vegetation model used for forests (MC1), and an economic model of the US forestry and agricultural sector (FASOM-GHG). We find substantial impacts on productivity, commodity markets, and consumer and producer welfare for the stabilization scenario relative to unabated climate change, though the magnitude and direction of impacts vary across regions and commodities. Although there is variability in welfare impacts across climate simulations, we find positive net benefits from stabilization in all cases, with cumulative impacts ranging from $32.7 billion to $54.5 billion over the period 2015-2100. Our estimates contribute to the literature on potential benefits of GHG mitigation and can help inform policy decisions weighing alternative mitigation and adaptation actions. C1 [Beach, Robert H.; Cai, Yongxia] RTI Int, Res Triangle Pk, NC 27709 USA. [Thomson, Allison; Zhang, Xuesong] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA. [Jones, Russell] Stratus Consulting Inc, Boulder, CO 80302 USA. [McCarl, Bruce A.] Texas A&M Univ, College Stn, TX 77843 USA. [Crimmins, Allison; Martinich, Jeremy; Cole, Jefferson; Ohrel, Sara; DeAngelo, Benjamin; McFarland, James] US EPA, Climate Change Div, Washington, DC 20460 USA. [Strzepek, Kenneth] MIT, Joint Program Sci & Policy Global Change, Cambridge, MA 02139 USA. [Boehlert, Brent] Ind Econ Inc, Cambridge, MA USA. RP Beach, RH (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM rbeach@rti.org; ycai@rti.org; athomson@fieldtomarket.org; Xuesong.Zhang@pnnl.gov; RJones@stratusconsulting.com; mccarl@tamu.edu; Crimmins.Allison@epa.gov; Martinich.Jeremy@epa.gov; Cole.Jefferson@epa.gov; Ohrel.Sara@epa.gov; DeAngelo.Ben@epa.gov; McFarland.James@epa.gov; strzepek@mit.edu; bboehlert@indecon.com RI zhang, xuesong/B-7907-2009; OI Boehlert, Brent/0000-0003-2540-4143 FU US Environmental Protection Agency's Climate Change Division [EP-BPA-12-H-0023, EP-B13H-00143] FX The authors wish to acknowledge the financial support of the US Environmental Protection Agency's Climate Change Division (Contract EP-BPA-12-H-0023, Call Order # EP-B13H-00143). Kaiguang Zhao and Erwan Monier provided technical contributions. We are also grateful for comments from two anonymous reviewers, which greatly improved the manuscript. The views expressed in this paper are solely those of the authors and do not necessarily reflect those of the US Environmental Protection Agency. NR 53 TC 3 Z9 3 U1 4 U2 23 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD SEP PY 2015 VL 10 IS 9 AR 095004 DI 10.1088/1748-9326/10/9/095004 PG 16 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ5KJ UT WOS:000367141000032 ER PT J AU Grigas, D Lehrter, J Cebrian, J Chen, YS Ehmen, B Woodrey, M AF Grigas, Daniel Lehrter, John Cebrian, Just Chen, Yushun Ehmen, Brenna Woodrey, Mark TI Effects of Stormwater Pipe Size and Rainfall on Sediment and Nutrients Delivered to a Coastal Bayou SO WATER ENVIRONMENT RESEARCH LA English DT Article DE stormwater; drainage pipes; pipe size; rain intensity; TSS; nutrients ID NITROGEN; STREAMS; RUNOFF; LOADS AB Pollutants discharged from stormwater pipes can cause water quality and ecosystem problems in coastal bayous. A study was conducted to characterize sediment and nutrients discharged by small and large (< 20 cm and.20 cm in internal diameters, respectively) pipes under different rainfall intensities (<2.54 cm and < 2.54 cm, respectively). Results showed that large pipes had greater discharge than small pipes. Pollutants concentrations did not vary by pipe size. Large pipes had greater loads of TSS (138.2 vs. 24.0 mg/s), NO3- (5.54 vs. 2.74 mg/s), and NH4+ (0.39 vs. 0.19 mg/s) than small pipes. Neither discharge nor constituents varied by rainfall events. Pipe size may be a useful metric for estimating loads to a system. Nutrient reduction efforts should be directed to reducing the dissolved nutrient pools, while stormwater management efforts should be directed to reducing pipe freshwater discharge volumes that drive constituent loads. C1 [Grigas, Daniel; Chen, Yushun] Univ Arkansas Pine Bluff, Aquaculture & Fisheries Ctr, Pine Bluff, AR 71601 USA. [Lehrter, John] US EPA, Off Res & Dev, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Cebrian, Just] Dauphin Isl Sea Lab, Dauphin Isl, AL 36528 USA. [Cebrian, Just] Univ S Alabama, Dept Marine Sci, Mobile, AL 36688 USA. [Ehmen, Brenna; Woodrey, Mark] Grand Bay Natl Estuarine Res Reserve, Moss Point, MS 39562 USA. [Woodrey, Mark] Mississippi State Univ, Coastal Res & Extens Ctr, Biloxi, MS 39532 USA. [Chen, Yushun] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China. RP Lehrter, J (reprint author), US EPA, Off Res & Dev, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM lehrter.john@epa.gov; yushunchen@ihb.ac.cn FU U.S. EPA [MX-95413009] FX We would like to thank the U.S. EPA for providing funding for this project (Award # MX-95413009) to the Grand Bay National Estuarine Research Reserve. The Dauphin Island Sea Lab and Grand Bay National Estuarine Research Reserve kindly provided facilities, equipment and additional personnel. In addition, several dedicated volunteers contributed significant hours in the field helping to collect these data. Finally, we thank the University of Arkansas at Pine Bluff Aquaculture/Fisheries Center faculty, staff, and students for providing assistance. Any opinions, findings, conclusions, or recommendations expressed herein are those of the authors and do not reflect the views of the U.S. EPA. NR 15 TC 1 Z9 1 U1 0 U2 5 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 EI 1554-7531 J9 WATER ENVIRON RES JI Water Environ. Res. PD SEP PY 2015 VL 87 IS 9 SI SI BP 796 EP 804 DI 10.2175/106143015X14362865226275 PG 9 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA CY5RV UT WOS:000366465900005 PM 26961474 ER PT J AU Knepp, T Pippin, M Crawford, J Chen, G Szykman, J Long, R Cowen, L Cede, A Abuhassan, N Herman, J Delgado, R Compton, J Berkoff, T Fishman, J Martins, D Stauffer, R Thompson, AM Weinheimer, A Knapp, D Montzka, D Lenschow, D Neil, D AF Knepp, T. Pippin, M. Crawford, J. Chen, G. Szykman, J. Long, R. Cowen, L. Cede, A. Abuhassan, N. Herman, J. Delgado, R. Compton, J. Berkoff, T. Fishman, J. Martins, D. Stauffer, R. Thompson, A. M. Weinheimer, A. Knapp, D. Montzka, D. Lenschow, D. Neil, D. TI Estimating surface NO2 and SO2 mixing ratios from fast-response total column observations and potential application to geostationary missions SO JOURNAL OF ATMOSPHERIC CHEMISTRY LA English DT Article DE Nitrogen dioxide; Sulfur dioxide; Air quality; Remote sensing; DISCOVER-AQ; CAPABLE; GEO-CAPE ID TROPOSPHERIC NITROGEN-DIOXIDE; AIR-POLLUTION; MAX-DOAS; PARTICULATE MATTER; URBAN-ENVIRONMENT; OZONE; ATMOSPHERE; INSTRUMENTS; SCIAMACHY; SATELLITE AB Total-column nitrogen dioxide (NO2) data collected by a ground-based sun-tracking spectrometer system (Pandora) and an photolytic-converter-based in-situ instrument collocated at NASA's Langley Research Center in Hampton, Virginia were analyzed to study the relationship between total-column and surface NO2 measurements. The measurements span more than a year and cover all seasons. Surface mixing ratios are estimated via application of a planetary boundary-layer (PBL) height correction factor. This PBL correction factor effectively corrects for boundary-layer variability throughout the day, and accounts for up to a parts per thousand 75 % of the variability between the NO2 data sets. Previous studies have made monthly and seasonal comparisons of column/surface data, which has shown generally good agreement over these long average times. In the current analysis comparisons of column densities averaged over 90 s and 1 h are made. Applicability of this technique to sulfur dioxide (SO2) is briefly explored. The SO2 correlation is improved by excluding conditions where surface levels are considered background. The analysis is extended to data from the July 2011 DISCOVER-AQ mission over the greater Baltimore, MD area to examine the method's performance in more-polluted urban conditions where NO2 concentrations are typically much higher. C1 [Knepp, T.] Sci Syst & Applicat Inc, Hampton, VA 23681 USA. [Knepp, T.; Pippin, M.; Crawford, J.; Chen, G.; Cowen, L.; Neil, D.] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Szykman, J.; Long, R.] US EPA, Durham, NC 27701 USA. [Cede, A.] LuftBlick, A-6162 Kreith, Austria. [Cede, A.; Abuhassan, N.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Abuhassan, N.] Morgan State Univ, Sch Engn, Baltimore, MD 21251 USA. [Herman, J.; Delgado, R.; Compton, J.; Berkoff, T.] Univ Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 21250 USA. [Fishman, J.] St Louis Univ, Dept Earth & Atmospher Sci, St Louis, MO 63103 USA. [Martins, D.; Stauffer, R.; Thompson, A. M.] Penn State Univ, Dept Meteorol, University Pk, PA 16802 USA. [Weinheimer, A.; Knapp, D.; Montzka, D.; Lenschow, D.] Natl Ctr Atmospher Res, Boulder, CO 80305 USA. RP Knepp, T (reprint author), Sci Syst & Applicat Inc, Hampton, VA 23681 USA. EM travis.n.knepp@nasa.gov RI Delgado, Ruben/F-9753-2016; OI Delgado, Ruben/0000-0002-7133-2462; Herman, Jay/0000-0002-9146-1632; Stauffer, Ryan/0000-0002-8583-7795; LENSCHOW, DONALD/0000-0003-4353-0098 FU NASA Applied Sciences Program; EPA collaborations under an EPA-LaRC memorandum of agreement; GEO-CAPE mission studies; Langley Innovative Partnership Program; NASA's post-doctoral program; National Science Foundation FX Funding for this work was provided by NASA Applied Sciences Program, EPA collaborations under an EPA-LaRC memorandum of agreement, GEO-CAPE mission studies, and Langley Innovative Partnership Program. T. Knepp was supported through NASA's post-doctoral program. The National Center for Atmospheric Research is sponsored by the National Science Foundation. Although this paper has been reviewed by the EPA and approved for publication, it does not necessarily reflect EPA policies or views. NR 56 TC 7 Z9 7 U1 5 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-7764 EI 1573-0662 J9 J ATMOS CHEM JI J. Atmos. Chem. PD SEP PY 2015 VL 72 IS 3-4 SI SI BP 261 EP 286 DI 10.1007/s10874-013-9257-6 PG 26 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CX6CP UT WOS:000365789100005 ER PT J AU Langlois, CL James, BR AF Langlois, Christina L. James, Bruce R. TI Chromium Oxidation-Reduction Chemistry at Soil Horizon Interfaces Defined by Iron and Manganese Oxides SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID HEXAVALENT CHROMIUM; NATURAL ENVIRONMENTS; PHYSICAL-PROPERTIES; SORPTION; ADSORPTION; COMPLEXES; MINERALS; BEHAVIOR; CR(VI); BIOACCESSIBILITY AB Soil interfaces, including those defined by horizons, are a largely unstudied area in soils research, especially in terms of oxidation-reduction properties and processes. Despite this lack of research, understanding these interfaces is essential to the complete understanding of chromium chemistry in soils. Chromium is most commonly found in its non-toxic trivalent [Cr(II)] and its toxic hexavalent [Cr(VI)] forms under normal environmental conditions. In soils, both Cr(II) and Cr(VI) can undergo oxidation-reduction processes as a result of microbes, organic C, or Fe(II)/Mn(II, IV) (hydr)oxides, and can exist as soluble ions in the soil solution, sorbed ions on the soil surface, soluble organic complexes, or precipitated compounds. Quantitatively determining each of these fractions of Cr can refine our understanding of how soil chemical properties and their differences across horizon interfaces may influence element speciation. This study addresses the question of how oxidation/reduction of Cr changes in mineralogically different soil horizons. The A and B horizons from seven soils encompassing a wide range of soil properties, were used in a series of leaching experiments which were set up as follows. Using a mechanical vacuum extractor, Cr(II) and Cr(VI) solutions were leached through A horizons, B horizons, and A horizons stacked on B horizons; the A horizon leachate was also leached through the B horizons in an attempt to dissect the mechanisms of interfacial oxidation-reduction processes. The Cr speciation results of the study indicate that there are significant interfacial properties affecting reduction of Cr(VI) in soils, but no interfacial effects on Cr(II) oxidation. C1 [Langlois, Christina L.; James, Bruce R.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. RP Langlois, CL (reprint author), US EPA, Off Resource Conserv & Recovery, Washington, DC 20460 USA. EM Langlois.christina@gmail.com NR 55 TC 0 Z9 0 U1 5 U2 32 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 0361-5995 EI 1435-0661 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD SEP-OCT PY 2015 VL 79 IS 5 BP 1329 EP 1339 DI 10.2136/sssaj2014.12.0476 PG 11 WC Soil Science SC Agriculture GA CX0PM UT WOS:000365399100008 ER PT J AU Vaddula, BR Yalla, S Gonzalez, MA AF Vaddula, Buchi Reddy Yalla, Swathi Gonzalez, Michael A. TI An Efficient and More Sustainable One-Step Continuous-Flow Multicomponent Synthesis Approach to Chromene Derivatives SO JOURNAL OF FLOW CHEMISTRY LA English DT Article DE 2-aminochromenes; arylidenemalononitriles; flow reactor; 1,8-diazabicycloundec-7-ene (DBU); process intensification; Knoevenagel condensation ID ONE-POT SYNTHESIS; NAPHTHOPYRAN DERIVATIVES; AQUEOUS-MEDIA; SUBSTITUTED 2-AMINO-2-CHROMENES; ROOM-TEMPERATURE; GREEN SYNTHESIS; CATALYST; 2-AMINO-4H-CHROMENES; CONDENSATION; CHEMISTRY AB A simple and rapid one-step continuous-flow synthesis route has been developed for the preparation of chromene derivatives from the reaction of aromatic aldehydes, a-cyanomethylene compounds, and naphthols. In this contribution, a one-step continuous-flow protocol in a ThalesNano H-Cube Pro T has been developed for the preparation of these chromene derivatives. This arises from the multicomponent one-step reaction of aromatic aldehydes, a-cyanomethylene compounds, and naphthols. This flow protocol was optimized in 2-methyltetrahydrofuran, which is a more environment-friendly solvent. The faster residence times (<2 min) coupled with elevated pressure (similar to 25 bar) results in an efficient, safer, faster, and modular reaction. Results obtained illustrate that this base-catalyzed reaction affords the respective chromene derivative products in very high yields. The products can then be easily purified by recrystallization, if desired. C1 [Vaddula, Buchi Reddy] ORISE, Oak Ridge, TN 37831 USA. [Vaddula, Buchi Reddy; Yalla, Swathi; Gonzalez, Michael A.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Gonzalez, MA (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 483, Cincinnati, OH 45268 USA. EM gonzalez.michael@epa.gov NR 21 TC 0 Z9 0 U1 5 U2 9 PU AKADEMIAI KIADO RT PI BUDAPEST PA PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY SN 2062-249X EI 2060-5587 J9 J FLOW CHEM JI J. Flow Chem. PD SEP PY 2015 VL 5 IS 3 BP 172 EP 177 DI 10.1556/1846.2015.00015 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA CW7NX UT WOS:000365187200012 ER PT J AU Lazar, JG Addy, K Gold, AJ Groffman, PM McKinney, RA Kellogg, DQ AF Lazar, Julia G. Addy, Kelly Gold, Arthur J. Groffman, Peter M. McKinney, Richard A. Kellogg, Dorothy Q. TI Beaver Ponds: Resurgent Nitrogen Sinks for Rural Watersheds in the Northeastern United States SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID ABIOTIC NITRATE INCORPORATION; CONSTRUCTED WETLANDS; CASTOR-CANADENSIS; AQUATIC ECOSYSTEMS; MICROBIAL BIOMASS; FOREST ECOSYSTEMS; MARINE-SEDIMENTS; ORGANIC-MATTER; FERROUS WHEEL; SOIL EXTRACTS AB Beaver-created ponds and dams, on the rise in the northeastern United States, reshape headwater stream networks from extensive, free-flowing reaches to complexes of ponds, wetlands, and connecting streams. We examined seasonal and annual rates of nitrate transformations in three beaver ponds in Rhode Island under enriched nitrate-nitrogen (N) conditions through the use of N-15 mass balance techniques on soil core mesocosm incubations. We recovered approximately 93% of the nitrate N from our mesocosm incubations. Of the added nitrate N, 22 to 39% was transformed during the course of the incubation. Denitrification had the highest rates of transformation (97-236 mg N m(-2) d(-1)), followed by assimilation into the organic soil N pool (41-93 mg N m(-2) d(-1)) and ammonium generation (11-14 mg N m(-2) d(-1)). Our denitrification rates exceeded those in several studies of freshwater ponds and wetlands; however, rates in those ecosystems may have been limited by low concentrations of nitrate. Assuming a density of 0.7 beaver ponds km(-2) of catchment area, we estimated that in nitrate-enriched watersheds, beaver pond denitrification can remove approximately 50 to 450 kg nitrate N km(-2) catchment area. In rural watersheds of southern New England with high N loading (i.e., 1000 kg km(-2)), denitrification from beaver ponds may remove 5 to 45% of watershed nitrate N loading. Beaver ponds represent a relatively new and substantial sink for watershed N if current beaver populations persist. C1 [Lazar, Julia G.; Addy, Kelly; Gold, Arthur J.; Kellogg, Dorothy Q.] Univ Rhode Isl, Dept Nat Resources Sci, Kingston, RI 02881 USA. [Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. [McKinney, Richard A.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Gold, AJ (reprint author), Univ Rhode Isl, Dept Nat Resources Sci, One Greenhouse Rd, Kingston, RI 02881 USA. EM agold@uri.edu FU USDA-NRCS; RI Agricultural Experiment Station [5426]; NSF EPSCoR [0554548] FX We thank undergraduates Molly Welsh, Mary Nicole Gutierrez, Jill Raval, Cody Miller, and Ellen Vancelette and graduate student Matt Wallace for field and laboratory assistance. We also appreciate reviewers for insightful comments on drafts of this manuscript. This project was supported by grants from USDA-NRCS, RI Agricultural Experiment Station (contribution no. 5426), and NSF EPSCoR Grant No. 0554548. NR 86 TC 2 Z9 2 U1 10 U2 29 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD SEP-OCT PY 2015 VL 44 IS 5 BP 1684 EP 1693 DI 10.2134/jeq2014.12.0540 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA CW3SH UT WOS:000364911600035 PM 26436285 ER PT J AU Dodder, RS Kaplan, PO Elobeid, A Tokgoz, S Secchi, S Kurkalova, LA AF Dodder, Rebecca S. Kaplan, P. Ozge Elobeid, Amani Tokgoz, Simla Secchi, Silvia Kurkalova, Lyubov A. TI Impact of energy prices and cellulosic biomass supply on agriculture, energy, and the environment: An integrated modeling approach SO ENERGY ECONOMICS LA English DT Article DE Biofuel; Ethanol; Agriculture; Natural gas; Crude oil; Cellulosic; Carbon dioxide ID GREENHOUSE-GAS EMISSIONS; COMMODITY PRICES; OIL PRICE; US; ETHANOL; TRANSMISSION; CAUSALITY; POLICIES; MARKETS AB The accelerated growth in biofuel markets has both created and reinforced linkages between agriculture and energy. The evolution of biofuel markets over the next 10-20 years and the implications for energy, agriculture, and the environment are uncertain. Building on an integrated agriculture-energy modeling framework, this study analyzes a baseline and three alternative scenarios: two scenarios based on energy prices (crude oil and natural gas) and one based on assumptions regarding cellulosic biomass availability. By examining the impact of scenarios driven by (a) changes in the energy sector and (b) changes in the agricultural sector, we can compare the differential effects on biofuels markets, commodity prices and quantities in each sector, and CO2 emissions. Scenario comparisons show biofuel markets affected more by crude oil prices than natural gas prices. However, higher natural gas prices shift the biofuel production mix away from corn-grain based to more cellulosic ethanol via multiple mechanisms. Alternatively, the scenario with no cellulosic feedstock lowers total ethanol production and raises ethanol and corn prices. In terms of environmental impacts, higher ethanol levels driven by higher oil prices lead to lower CO2 emissions. In comparison, the no cellulosic scenario results in the highest CO2 trajectory relative to the baseline. Published by Elsevier B.V. C1 [Dodder, Rebecca S.; Kaplan, P. Ozge] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Elobeid, Amani] Iowa State Univ, Ctr Agr & Rural Dev, Ames, IA 50011 USA. [Tokgoz, Simla] Int Food Policy Res Inst, Washington, DC 20006 USA. [Secchi, Silvia] So Illinois Univ, Dept Geog & Environm Resources, Carbondale, IL 62901 USA. [Kurkalova, Lyubov A.] N Carolina Agr & Tech State Univ, Dept Econ, Greensboro, NC 27411 USA. [Kurkalova, Lyubov A.] N Carolina Agr & Tech State Univ, Dept Energy & Environm Syst, Greensboro, NC 27411 USA. RP Dodder, RS (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. OI Tokgoz, Simla/0000-0002-9358-0491 FU United States Department of Agriculture's National Institute of Food and Agriculture, Agriculture and Food Research Initiative [2010-65400-20434] FX This paper is based upon research funded by the United States Department of Agriculture's National Institute of Food and Agriculture, Agriculture and Food Research Initiative, Award number 2010-65400-20434. The funding source had no involvement in the study design, data collection and analysis, or in any other aspects of the research or paper publication. This article has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency or the U.S. Department of Agriculture. We also thank the anonymous reviewers for their constructive feedback and suggestions. NR 38 TC 2 Z9 3 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0140-9883 EI 1873-6181 J9 ENERG ECON JI Energy Econ. PD SEP PY 2015 VL 51 BP 77 EP 87 DI 10.1016/j.eneco.2015.06.008 PG 11 WC Economics SC Business & Economics GA CV7GD UT WOS:000364439500008 ER PT J AU Kuppusamy, SP Kaiser, JP Wesselkamper, SC AF Kuppusamy, Senthilkumar P. Kaiser, J. Phillip Wesselkamper, Scott C. TI Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE epigenetics; DNA methylation; cancer; human health risk assessment ID PRODUCT-SAFETY ASSESSMENT; C-MYC PROTOONCOGENES; MOUSE-LIVER TUMORS; DNA METHYLATION; TRICHLOROACETIC-ACID; DICHLOROACETIC ACID; DRINKING-WATER; HUMAN CANCERS; B6C3F1 MICE; GENE AB Although several studies have shown that chemically mediated epigenetic changes are an etiological factor in several human disease conditions, the utility of epigenetic data, such as DNA methylation, in the current human health risk assessment paradigm is unclear. The objective of this study is to investigate the relationship between the points of departure (PODs) for cancer incidence and DNA methylation changes in laboratory animals exposed to the following environmental toxicants: bromodichloromethane, dibromochloromethane, chloroform, hydrazine, trichloroethylene, benzidine, trichloroacetic acid, and di(2-ethylhexyl) phthalate (DEHP; a known reproductive toxicant). The results demonstrate that the PODs for cancer incidence and altered DNA methylation are similar. Furthermore, based on the available data, the POD for DNA methylation appeared more sensitive compared to that for cancer incidence following the administration of DEHP to rats during different life stages. The high degree of correlation between PODs for cancer incidence and DNA methylation (for both total DNA and individual genes) suggests that DNA methylation end points could potentially be used as a screening tool in predicting the potential toxicity/carcinogenicity and in prioritizing large numbers of chemicals with sparse toxicity databases. The life stage during which treatment occurs is also an important consideration when assessing the potential application of epigenetic end points as a screening tool. C1 [Kuppusamy, Senthilkumar P.] US EPA, Off Res & Dev, NCEA, Oak Ridge Inst Sci & Educ Participant, Cincinnati, OH 45268 USA. [Kaiser, J. Phillip; Wesselkamper, Scott C.] US EPA, Off Res & Dev, NCEA, Cincinnati, OH 45268 USA. RP Wesselkamper, SC (reprint author), US EPA, Off Res & Dev, NCEA, 26 West Martin Luther King Dr MS A-110, Cincinnati, OH 45268 USA. EM wesselkamper.scott@epa.gov NR 69 TC 1 Z9 2 U1 1 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP-OCT PY 2015 VL 34 IS 5 BP 384 EP 392 DI 10.1177/1091581815599350 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CV0YF UT WOS:000363979100002 PM 26268770 ER PT J AU Pleil, JD AF Pleil, J. D. TI The next chapter for the Journal of Breath Research SO JOURNAL OF BREATH RESEARCH LA English DT Editorial Material C1 [Pleil, J. D.] US EPA, Res Triangle Pk, NC 27711 USA. [Pleil, J. D.] Univ N Carolina, Chapel Hill, NC USA. RP Pleil, JD (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM pleil@unc.edu NR 0 TC 1 Z9 1 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD SEP PY 2015 VL 9 IS 3 AR 030201 DI 10.1088/1752-7155/9/3/030201 PG 2 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA CW1YY UT WOS:000364789300001 PM 26389828 ER PT J AU Pleil, JD Beauchamp, JD Miekisch, W Funk, WE AF Pleil, Joachim D. Beauchamp, Jonathan D. Miekisch, Wolfram Funk, William E. TI Adapting biomarker technologies to adverse outcome pathways (AOPs) research: current thoughts on using in vivo discovery for developing in vitro target methods SO JOURNAL OF BREATH RESEARCH LA English DT Article DE toxicity testing; breath analysis; molecular initiating event ID ADDUCTS C1 [Pleil, Joachim D.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Beauchamp, Jonathan D.] Fraunhofer IVV, Dept Sensory Analyt, D-85354 Freising Weihenstephan, Germany. [Miekisch, Wolfram] Univ Med Ctr Rostock, Dept Anaesthesia & Intens Care Med, Rostock, Germany. [Funk, William E.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA. RP Pleil, JD (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM pleil.joachim@epa.gov; jonathan.beauchamp@ivv.fraunhofer.de; wolfram.miekisch@uni-rostock.de; w-funk@northwestern.edu RI Beauchamp, Jonathan/J-6914-2014 OI Beauchamp, Jonathan/0000-0003-1405-7625 NR 38 TC 10 Z9 10 U1 0 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD SEP PY 2015 VL 9 IS 3 AR 039001 DI 10.1088/1752-7155/9/3/039001 PG 6 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA CW1YY UT WOS:000364789300014 PM 26173025 ER PT J AU Yang, J Bennett, BD Luo, SJ Inoue, K Grimm, SA Schroth, GP Bushel, PR Kinyamu, HK Archer, TK AF Yang, Jun Bennett, Brian D. Luo, Shujun Inoue, Kaoru Grimm, Sara A. Schroth, Gary P. Bushel, Pierre R. Kinyamu, H. Karimi Archer, Trevor K. TI LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID EMBRYONIC STEM-CELLS; PYRUVATE-KINASE; MESSENGER-RNA; LET-7 MICRORNA; HNRNP PROTEINS; GLUCOCORTICOID-RECEPTOR; HMENA ENAH; LIN-28; TRANSFORMATION; REVEALS AB LIN28 is an evolutionarily conserved RNA-binding protein with critical functions in developmental timing and cancer. However, the molecular mechanisms underlying LIN28's oncogenic properties are yet to be described. RNA-protein immunoprecipitation coupled with genome-wide sequencing (RIP-Seq) analysis revealed significant LIN28 binding within 843 mRNAs in breast cancer cells. Many of the LIN28-bound mRNAs are implicated in the regulation of RNA and cell metabolism. We identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), a protein with multiple roles in mRNA metabolism, as a LIN28-interacting partner. Subsequently, we used a custom computational method to identify differentially spliced gene isoforms in LIN28 and hnRNP A1 small interfering RNA (siRNA)-treated cells. The results reveal that these proteins regulate alternative splicing and steady-state mRNA expression of genes implicated in aspects of breast cancer biology. Notably, cells lacking LIN28 undergo significant isoform switching of the ENAH gene, resulting in a decrease in the expression of the ENAH exon 11a isoform. The expression of ENAH isoform 11a has been shown to be elevated in breast cancers that express HER2. Intriguingly, analysis of publicly available array data from the Cancer Genome Atlas (TCGA) reveals that LIN28 expression in the HER2 subtype is significantly different from that in other breast cancer subtypes. Collectively, our data suggest that LIN28 may regulate splicing and gene expression programs that drive breast cancer subtype phenotypes. C1 [Yang, Jun; Inoue, Kaoru; Kinyamu, H. Karimi; Archer, Trevor K.] Natl Inst Environm Hlth Sci, Chromatin & Gene Express Sect, Epigenet & Stem Cell Biol Lab, NIH, Res Triangle Pk, NC USA. [Bennett, Brian D.; Grimm, Sara A.] Natl Inst Environm Hlth Sci, Integrat Bioinformat, NIH, Res Triangle Pk, NC USA. [Luo, Shujun; Schroth, Gary P.] Illumina Inc, Res & Dev, Hayward, CA 94545 USA. [Bushel, Pierre R.] Natl Inst Environm Hlth Sci, Biostat Branch, NIH, Res Triangle Pk, NC USA. RP Kinyamu, HK (reprint author), Illumina Inc, Res & Dev, Hayward, CA 94545 USA. EM kinyamu@niehs.nih.gov; archer1@niehs.nih.gov FU Intramural Research Program of the National Institute of Environmental Health Sciences, NIH [Z01 ES071006-15] FX This research was supported by the Intramural Research Program of the National Institute of Environmental Health Sciences, NIH (project number Z01 ES071006-15). NR 62 TC 4 Z9 4 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 EI 1098-5549 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD SEP PY 2015 VL 35 IS 18 BP 3225 EP 3243 DI 10.1128/MCB.00426-15 PG 19 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CV8AT UT WOS:000364499600011 PM 26149387 ER PT J AU Boehlert, B Strzepek, KM Chapra, SC Fant, C Gebretsadik, Y Lickley, M Swanson, R McCluskey, A Neumann, JE Martinich, J AF Boehlert, Brent Strzepek, Kenneth M. Chapra, Steven C. Fant, Charles Gebretsadik, Yohannes Lickley, Megan Swanson, Richard McCluskey, Alyssa Neumann, James E. Martinich, Jeremy TI Climate change impacts and greenhouse gas mitigation effects on US water quality SO JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS LA English DT Article ID RESERVOIRS; LAKES AB Climate change will have potentially significant effects on freshwater quality due to increases in river and lake temperatures, changes in the magnitude and seasonality of river runoff, and more frequent and severe extreme events. These physical impacts will in turn have economic consequences through effects on riparian development, river and reservoir recreation, water treatment, harmful aquatic blooms, and a range of other sectors. In this paper, we analyze the physical and economic effects of changes in freshwater quality across the contiguous U.S. in futures with and without global-scale greenhouse gas mitigation. Using a water allocation and quality model of 2119 river basins, we estimate the impacts of various projected emissions outcomes on several key water quality indicators, and monetize these impacts with a water quality index approach. Under mitigation, we find that water temperatures decrease considerably and that dissolved oxygen levels rise in response. We find that the annual economic impacts on water quality of a high emissions scenario rise from $1.4 billion in 2050 to $4 billion in 2100, leading to present value mitigation benefits, discounted at 3%, of approximately $17.5 billion over the 2015-2100 period. C1 [Boehlert, Brent; Neumann, James E.] Ind Econ Inc, Cambridge, MA 02140 USA. [Boehlert, Brent; Strzepek, Kenneth M.; Fant, Charles; Gebretsadik, Yohannes; Lickley, Megan] MIT, Joint Program Sci & Policy Global Change, Cambridge, MA 02139 USA. [Chapra, Steven C.] Tufts Univ, Dept Civil & Environm Engn, Medford, MA 02155 USA. [Swanson, Richard; McCluskey, Alyssa] Univ Colorado, Civil Engn, Boulder, CO 80309 USA. [Martinich, Jeremy] US EPA, Washington, DC 20460 USA. RP Boehlert, B (reprint author), Ind Econ Inc, Cambridge, MA 02140 USA. EM bboehlert@indecon.com RI Chapra, Steven/A-5752-2008; OI Chapra, Steven/0000-0003-0238-6376; , /0000-0001-9494-785X; Boehlert, Brent/0000-0003-2540-4143 FU U.S. Environmental Protection Agency's (EPA's) Climate Change Division [EP-D-09-054] FX We acknowledge the financial support of the U.S. Environmental Protection Agency's (EPA's) Climate Change Division (contract #EP-D-09-054) and access to reservoir data sets from the U.S. Army Corps of Engineers. Technical contributions were provided by Nicolas Tyack, Lisa Rennels, and Andrzej Strzepek. Data used to produce the results of this paper can be made available through the corresponding author, Brent Boehlert, at bboehlert@indecon.com. NR 51 TC 6 Z9 6 U1 8 U2 21 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 1942-2466 J9 J ADV MODEL EARTH SY JI J. Adv. Model. Earth Syst. PD SEP PY 2015 VL 7 IS 3 BP 1326 EP 1338 DI 10.1002/2014MS000400 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CU1JV UT WOS:000363278200019 ER PT J AU Ma, X Xue, XB Gonzalez-Meija, A Garland, J Cashdollar, J AF Ma, Xin (Cissy) Xue, Xiaobo Gonzalez-Meija, Alejandra Garland, Jay Cashdollar, Jennifer TI Sustainable Water Systems for the City of Tomorrow-A Conceptual Framework SO SUSTAINABILITY LA English DT Review DE urban water systems; paradigm shift; system-based analysis; resource recovery; energy recovery; nutrient recovery; fit-for-purpose; dual water quality; system efficiency; emergy synthesis ID DOMESTIC WASTE-WATER; RESOURCE RECOVERY; NUTRIENT REMOVAL; ANAEROBIC TREATMENT; DRINKING-WATER; URBAN WATER; EMERGING CONTAMINANTS; CONSTRUCTED WETLANDS; COMMUNITY WATER; UASB REACTOR AB Urban water systems are an example of complex, dynamic human-environment coupled systems which exhibit emergent behaviors that transcend individual scientific disciplines. While previous siloed approaches to water services (i.e., water resources, drinking water, wastewater, and stormwater) have led to great improvements in public health protection, sustainable solutions for a growing global population facing increased resource constraints demand a paradigm shift based on holistic management to maximize the use and recovery of water, energy, nutrients, and materials. The objective of this review paper is to highlight the issues in traditional water systems including water demand and use, centralized configuration, sewer collection systems, characteristics of mixed wastewater, and to explore alternative solutions such as decentralized water systems, fit for purpose and water reuse, natural/green infrastructure, vacuum sewer collection systems, and nutrient/energy recovery. This review also emphasizes a system thinking approach for evaluating alternatives that should include sustainability indicators and metrics such as emergy to assess global system efficiency. An example paradigm shift design for urban water system is presented, not as the recommended solution for all environments, but to emphasize the framework of system-level analysis and the need to visualize water services as an organic whole. When water systems are designed to maximize the resources and optimum efficiency, they are more prevailing and sustainable than siloed management because a system is more than the sum of its parts. C1 [Ma, Xin (Cissy)] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Xue, Xiaobo; Gonzalez-Meija, Alejandra] US EPA, Natl Risk Management Res Lab, Oak Ridge Inst Sci & Engn, Cincinnati, OH 45268 USA. [Garland, Jay; Cashdollar, Jennifer] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Ma, X (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM ma.cissy@epa.gov; xue.xiaobo@epa.gov; gonzalez.alejandra@epa.gov; garland.jay@epa.gov; cashdollar.jennifer@epa.gov NR 168 TC 5 Z9 5 U1 19 U2 85 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD SEP PY 2015 VL 7 IS 9 BP 12071 EP 12105 DI 10.3390/su70912071 PG 35 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA CT1JA UT WOS:000362553400037 ER PT J AU Huang, JQ Goltz, MN AF Huang, Junqi Goltz, Mark N. TI Semianalytical solutions for transport in aquifer and fractured clay matrix system SO WATER RESOURCES RESEARCH LA English DT Article DE semianalytical solution; fate and transport; integral transforms; fractured clay matrix ID BACK-DIFFUSION; PLUME PERSISTENCE; NAPL DISSOLUTION; POROUS-MEDIA; SOURCE ZONES; AQUITARD; PREDICTIONS; MODELS; WELL AB A three-dimensional mathematical model that describes transport of contaminant in a horizontal aquifer with simultaneous diffusion into a fractured clay formation is proposed. A group of semianalytical solutions is derived based on specific initial and boundary conditions as well as various source functions. The analytical model solutions are evaluated by numerical Laplace inverse transformation and analytical Fourier inverse transformation. The model solutions can be used to study the fate and transport in a three-dimensional spatial domain in which a nonaqueous phase liquid exists as a pool atop a fractured low-permeability clay layer. The nonaqueous phase liquid gradually dissolves into the groundwater flowing past the pool, while simultaneously diffusing into the fractured clay formation below the aquifer. Mass transfer of the contaminant into the clay formation is demonstrated to be significantly enhanced by the existence of the fractures, even though the volume of fractures is relatively small compared to the volume of the clay matrix. The model solution is a useful tool in assessing contaminant attenuation processes in a confined aquifer underlain by a fractured clay formation. C1 [Huang, Junqi] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Ada, OK 74821 USA. [Goltz, Mark N.] Air Force Inst Technol, Dept Syst Engn & Management, Dayton, OH USA. RP Huang, JQ (reprint author), US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Ada, OK 74821 USA. EM huang.junqi@epa.gov FU Strategic Environmental Research and Development Program [ER-1737] FX MATLAB (R) codes created for this analysis are available upon request by e-mail: huang.junqi@epa.gov. Portions of this research were sponsored by Strategic Environmental Research and Development Program, project ER-1737. The authors are grateful for the constructive comments from the Editor, two anonymous reviewers, and E. J. M. Veling. The content of this manuscript has not been subject to agency review and does not necessarily represent the view of the sponsoring agency. Additionally, the views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the United States Air Force, Department of Defense, or the U.S. Government. NR 32 TC 0 Z9 0 U1 2 U2 10 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD SEP PY 2015 VL 51 IS 9 BP 7218 EP 7237 DI 10.1002/2014WR016073 PG 20 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA CU2YZ UT WOS:000363391300018 ER EF